locus-tag	class	description
O2N64_RS00005	COG0088	Forms part of the polypeptide exit tunnel
O2N64_RS00010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O2N64_RS00015	COG0051	transcription antitermination factor activity, RNA binding
O2N64_RS00020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O2N64_RS00025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O2N64_RS00030	COG0049	tRNA binding
O2N64_RS00035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
O2N64_RS00055	COG2197	response regulator
O2N64_RS00065	COG1404	Belongs to the peptidase S8 family
O2N64_RS00085	COG3228	Belongs to the MtfA family
O2N64_RS00090	COG0583	DNA-binding transcription factor activity
O2N64_RS00100	COG2967	ApaG domain
O2N64_RS00135	COG0473	3-isopropylmalate dehydrogenase activity
O2N64_RS00140	COG1381	Involved in DNA repair and RecF pathway recombination
O2N64_RS00155	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
O2N64_RS00175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O2N64_RS00195	COG1054	Belongs to the UPF0176 family
O2N64_RS00210	COG0625	glutathione transferase activity
O2N64_RS00235	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
O2N64_RS00240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O2N64_RS00245	COG2199	diguanylate cyclase activity
O2N64_RS00250	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
O2N64_RS00255	COG0612	Peptidase, M16
O2N64_RS00260	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
O2N64_RS00265	COG0778	Nitroreductase
O2N64_RS00280	COG4957	zinc ion binding
O2N64_RS00300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O2N64_RS00335	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
O2N64_RS00340	COG1253	flavin adenine dinucleotide binding
O2N64_RS00345	COG0583	DNA-binding transcription factor activity
O2N64_RS00360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O2N64_RS00365	COG2239	Acts as a magnesium transporter
O2N64_RS00415	COG1194	a g-specific adenine glycosylase
O2N64_RS00435	COG1196	nuclear chromosome segregation
O2N64_RS00440	COG0789	Transcriptional regulator
O2N64_RS00455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
O2N64_RS00480	COG0438	transferase activity, transferring glycosyl groups
O2N64_RS00490	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
O2N64_RS00495	COG1012	belongs to the aldehyde dehydrogenase family
O2N64_RS00505	COG0418	dihydroorotase activity
O2N64_RS00535	COG0211	Belongs to the bacterial ribosomal protein bL27 family
O2N64_RS00540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O2N64_RS00565	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O2N64_RS00615	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
O2N64_RS00625	COG0109	protoheme IX farnesyltransferase activity
O2N64_RS00630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O2N64_RS00635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O2N64_RS00640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O2N64_RS00650	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
O2N64_RS00655	COG0736	holo-[acyl-carrier-protein] synthase activity
O2N64_RS00660	COG0681	Belongs to the peptidase S26 family
O2N64_RS00675	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O2N64_RS00695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O2N64_RS00695	COG1648	precorrin-2 dehydrogenase activity
O2N64_RS00700	COG0019	diaminopimelate decarboxylase activity
O2N64_RS00710	COG0165	Argininosuccinate lyase
O2N64_RS00720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O2N64_RS00730	COG0252	asparaginase activity
O2N64_RS00740	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
O2N64_RS00755	COG0656	L-ascorbic acid biosynthetic process
O2N64_RS00760	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
O2N64_RS00765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O2N64_RS00780	COG4566	intracellular signal transduction
O2N64_RS00800	COG2308	Evidence 4 Homologs of previously reported genes of
O2N64_RS00830	COG0556	nucleotide-excision repair
O2N64_RS00845	COG4232	protein-disulfide reductase activity
O2N64_RS00850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O2N64_RS00865	COG0181	hydroxymethylbilane synthase activity
O2N64_RS00870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O2N64_RS00875	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O2N64_RS00895	COG1960	acyl-CoA dehydrogenase activity
O2N64_RS00900	COG2885	chlorophyll binding
O2N64_RS00900	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
O2N64_RS00905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O2N64_RS00930	COG0577	efflux transmembrane transporter activity
O2N64_RS00930	COG1136	(ABC) transporter
O2N64_RS00935	COG1136	(ABC) transporter
O2N64_RS00935	COG0577	efflux transmembrane transporter activity
O2N64_RS00955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O2N64_RS00960	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
O2N64_RS00970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O2N64_RS00975	COG0745	RESPONSE REGULATOR receiver
O2N64_RS01005	COG1082	Xylose isomerase domain protein TIM barrel
O2N64_RS01010	COG0366	Alpha amylase catalytic
O2N64_RS01075	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
O2N64_RS01105	COG1063	alcohol dehydrogenase
O2N64_RS01110	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
O2N64_RS01115	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
O2N64_RS01120	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
O2N64_RS01155	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
O2N64_RS01160	COG0644	oxidoreductase
O2N64_RS01165	COG2211	Major facilitator Superfamily
O2N64_RS01170	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
O2N64_RS01190	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
O2N64_RS01200	COG1429	ligase activity, forming nitrogen-metal bonds
O2N64_RS01205	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
O2N64_RS01240	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
O2N64_RS01250	COG0156	8-amino-7-oxononanoate synthase activity
O2N64_RS01275	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O2N64_RS01290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O2N64_RS01300	COG3047	cAMP biosynthetic process
O2N64_RS01325	COG2010	Cytochrome c
O2N64_RS01340	COG2217	Heavy metal translocating P-type atpase
O2N64_RS01355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O2N64_RS01360	COG1760	l-serine dehydratase
O2N64_RS01365	COG2814	Major facilitator Superfamily
O2N64_RS01370	COG2267	carboxylic ester hydrolase activity
O2N64_RS01375	COG4771	TonB-dependent receptor
O2N64_RS01380	COG1309	transcriptional regulator
O2N64_RS01465	COG2264	protein methyltransferase activity
O2N64_RS01495	COG4650	regulator
O2N64_RS01505	COG1690	Belongs to the RtcB family
O2N64_RS01510	COG3541	Predicted nucleotidyltransferase
O2N64_RS01515	COG0430	RNA-3'-phosphate cyclase activity
O2N64_RS01520	COG0488	(ABC) transporter
O2N64_RS01550	COG0569	domain protein
O2N64_RS01555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O2N64_RS01595	COG0408	coproporphyrinogen oxidase activity
O2N64_RS01605	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
O2N64_RS01630	COG0471	metal ion transport
O2N64_RS01645	COG3850	Histidine kinase
O2N64_RS01645	COG4999	Histidine kinase
O2N64_RS01645	COG2205	protein histidine kinase activity
O2N64_RS01645	COG3437	response regulator, receiver
O2N64_RS01650	COG0484	heat shock protein binding
O2N64_RS01660	COG2885	chlorophyll binding
O2N64_RS01665	COG0823	Involved in the tonB-independent uptake of proteins
O2N64_RS01685	COG0824	Thioesterase
O2N64_RS01695	COG0140	phosphoribosyl-ATP diphosphatase activity
O2N64_RS01705	COG0107	imidazoleglycerol-phosphate synthase activity
O2N64_RS01710	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O2N64_RS01715	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O2N64_RS01725	COG0131	Imidazoleglycerol-phosphate dehydratase
O2N64_RS01740	COG0194	GDP metabolic process
O2N64_RS01745	COG1404	Belongs to the peptidase S8 family
O2N64_RS01750	COG2171	N-acyltransferase activity
O2N64_RS01830	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
O2N64_RS01895	COG1671	Belongs to the UPF0178 family
O2N64_RS01925	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
O2N64_RS01940	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
O2N64_RS01975	COG1506	peptidase
O2N64_RS01975	COG0823	Involved in the tonB-independent uptake of proteins
O2N64_RS01975	COG4946	Tricorn protease homolog
O2N64_RS02020	COG4770	biotin carboxylase activity
O2N64_RS02025	COG4989	oxidoreductase activity
O2N64_RS02035	COG2814	Major facilitator Superfamily
O2N64_RS02050	COG1051	belongs to the nudix hydrolase family
O2N64_RS02060	COG0783	Belongs to the Dps family
O2N64_RS02130	COG1024	Enoyl-CoA hydratase
O2N64_RS02135	COG3001	Fructosamine kinase
O2N64_RS02140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O2N64_RS02150	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
O2N64_RS02185	COG1215	transferase activity, transferring glycosyl groups
O2N64_RS02200	COG5265	(ABC) transporter
O2N64_RS02210	COG0659	secondary active sulfate transmembrane transporter activity
O2N64_RS02245	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
O2N64_RS02250	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
O2N64_RS02290	COG0629	single-stranded DNA binding
O2N64_RS02315	COG1999	signal sequence binding
O2N64_RS02320	COG2983	Belongs to the UPF0260 family
O2N64_RS02335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O2N64_RS02335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O2N64_RS02355	COG1448	Aminotransferase
O2N64_RS02370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O2N64_RS02380	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O2N64_RS02385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O2N64_RS02400	COG1472	Belongs to the glycosyl hydrolase 3 family
O2N64_RS02410	COG1609	Transcriptional regulator
O2N64_RS02450	COG0739	heme binding
O2N64_RS02450	COG1196	nuclear chromosome segregation
O2N64_RS02450	COG0741	lytic transglycosylase activity
O2N64_RS02465	COG3451	type IV secretory pathway VirB4
O2N64_RS02475	COG3504	Conjugal transfer protein
O2N64_RS02480	COG2948	multi-organism process
O2N64_RS02485	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
O2N64_RS02490	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
O2N64_RS02520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O2N64_RS02525	COG2072	flavoprotein involved in K transport
O2N64_RS02530	COG1546	Belongs to the CinA family
O2N64_RS02530	COG1058	Belongs to the CinA family
O2N64_RS02545	COG0081	regulation of translation
O2N64_RS02550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
O2N64_RS02560	COG3279	Response regulator of the LytR AlgR family
O2N64_RS02580	COG1115	amino acid carrier protein
O2N64_RS02600	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
O2N64_RS02605	COG4765	Protein conserved in bacteria
O2N64_RS02625	COG0318	PFAM AMP-dependent synthetase and ligase
O2N64_RS02675	COG4251	negative regulation of phosphorylation
O2N64_RS02715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O2N64_RS02715	COG3453	Protein conserved in bacteria
O2N64_RS02730	COG0251	oxidation-reduction process
O2N64_RS02750	COG1024	Enoyl-CoA hydratase
O2N64_RS02755	COG4770	biotin carboxylase activity
O2N64_RS02775	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O2N64_RS02775	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O2N64_RS02780	COG0346	lactoylglutathione lyase activity
O2N64_RS02785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O2N64_RS02790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O2N64_RS02800	COG0471	metal ion transport
O2N64_RS02840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O2N64_RS02845	COG3507	Belongs to the glycosyl hydrolase 43 family
O2N64_RS02865	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O2N64_RS02875	COG0489	protein tyrosine kinase activity
O2N64_RS02880	COG0330	HflC and HflK could
O2N64_RS02895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O2N64_RS02900	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O2N64_RS02920	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
O2N64_RS02930	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
O2N64_RS02940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O2N64_RS02940	COG2813	Specifically methylates the guanine in position
O2N64_RS02945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O2N64_RS02950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O2N64_RS02955	COG0287	Prephenate dehydrogenase
O2N64_RS02960	COG1024	Enoyl-CoA hydratase
O2N64_RS02980	COG3483	tryptophan 2,3-dioxygenase activity
O2N64_RS02985	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
O2N64_RS02995	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O2N64_RS03000	COG1741	Belongs to the pirin family
O2N64_RS03020	COG2884	Cell division ATP-binding protein ftsE
O2N64_RS03055	COG0717	Belongs to the dCTP deaminase family
O2N64_RS03060	COG4206	TonB-dependent receptor
O2N64_RS03065	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
O2N64_RS03065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O2N64_RS03085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O2N64_RS03090	COG0085	RNA polymerase activity
O2N64_RS03115	COG3655	Transcriptional regulator
O2N64_RS03125	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
O2N64_RS03130	COG0222	ribosome binding
O2N64_RS03155	COG0534	Mate efflux family protein
O2N64_RS03160	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
O2N64_RS03165	COG0459	protein refolding
O2N64_RS03190	COG1937	Protein conserved in bacteria
O2N64_RS03195	COG2132	Multicopper oxidase
O2N64_RS03225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O2N64_RS03225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O2N64_RS03235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O2N64_RS03280	COG4152	abc transporter atp-binding protein
O2N64_RS03305	COG2814	Major facilitator Superfamily
O2N64_RS03310	COG2311	Membrane
O2N64_RS03315	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O2N64_RS03320	COG0815	Transfers the fatty acyl group on membrane lipoproteins
O2N64_RS03330	COG2890	protein-(glutamine-N5) methyltransferase activity
O2N64_RS03335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O2N64_RS03340	COG0124	histidyl-tRNA synthetase
O2N64_RS03345	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
O2N64_RS03360	COG0668	transmembrane transport
O2N64_RS03370	COG1137	ATPase activity
O2N64_RS03375	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
O2N64_RS03400	COG0530	calcium, potassium:sodium antiporter activity
O2N64_RS03415	COG0745	RESPONSE REGULATOR receiver
O2N64_RS03420	COG0668	transmembrane transport
O2N64_RS03425	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O2N64_RS03435	COG3273	potassium ion transport
O2N64_RS03435	COG0471	metal ion transport
O2N64_RS03440	COG0281	malic enzyme
O2N64_RS03440	COG0280	phosphate acetyltransferase
O2N64_RS03445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
O2N64_RS03465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O2N64_RS03480	COG4166	transmembrane transport
O2N64_RS03540	COG0156	8-amino-7-oxononanoate synthase activity
O2N64_RS03550	COG1764	response to oxidative stress
O2N64_RS03580	COG4695	Portal protein
O2N64_RS03660	COG2032	superoxide dismutase activity
O2N64_RS03665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
O2N64_RS03680	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O2N64_RS03685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O2N64_RS03690	COG1278	Cold shock
O2N64_RS03705	COG2885	chlorophyll binding
O2N64_RS03710	COG0347	Belongs to the P(II) protein family
O2N64_RS03715	COG0004	ammonium transporteR
O2N64_RS03720	COG0347	Belongs to the P(II) protein family
O2N64_RS03735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
O2N64_RS03740	COG4221	oxidoreductase activity
O2N64_RS03745	COG0072	phenylalanine-tRNA ligase activity
O2N64_RS03750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O2N64_RS03755	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
O2N64_RS03760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
O2N64_RS03770	COG4771	TonB-dependent receptor
O2N64_RS03780	COG0483	inositol monophosphate 1-phosphatase activity
O2N64_RS03795	COG1494	fructose-1,6-bisphosphatase
O2N64_RS03845	COG1201	RNA secondary structure unwinding
O2N64_RS03870	COG1192	Involved in chromosome partitioning
O2N64_RS03875	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O2N64_RS03905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O2N64_RS03925	COG1496	oxidoreductase activity
O2N64_RS03930	COG0308	aminopeptidase N
O2N64_RS03980	COG0588	phosphoglycerate mutase activity
O2N64_RS03990	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
O2N64_RS04005	COG0196	riboflavin kinase activity
O2N64_RS04015	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O2N64_RS04020	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O2N64_RS04055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O2N64_RS04060	COG2274	protein secretion by the type I secretion system
O2N64_RS04080	COG0590	tRNA wobble adenosine to inosine editing
O2N64_RS04085	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O2N64_RS04105	COG1570	exodeoxyribonuclease VII activity
O2N64_RS04110	COG0151	Belongs to the GarS family
O2N64_RS04115	COG0583	DNA-binding transcription factor activity
O2N64_RS04125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O2N64_RS04145	COG0316	Belongs to the HesB IscA family
O2N64_RS04150	COG2151	metal-sulfur cluster biosynthetic enzyme
O2N64_RS04155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O2N64_RS04160	COG0719	Fe-S assembly protein
O2N64_RS04170	COG0396	ATPase activity
O2N64_RS04190	COG0719	Fe-S assembly protein
O2N64_RS04215	COG0167	dihydroorotate dehydrogenase activity
O2N64_RS04220	COG0405	Gamma-glutamyltransferase
O2N64_RS04225	COG1022	Amp-dependent synthetase and ligase
O2N64_RS04240	COG2022	thiamine diphosphate biosynthetic process
O2N64_RS04250	COG1612	heme a metabolic process
O2N64_RS04265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O2N64_RS04270	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O2N64_RS04305	COG3275	phosphorelay sensor kinase activity
O2N64_RS04330	COG3411	Ferredoxin
O2N64_RS04340	COG0617	tRNA 3'-terminal CCA addition
O2N64_RS04340	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
O2N64_RS04340	COG3620	sequence-specific DNA binding
O2N64_RS04345	COG0316	Belongs to the HesB IscA family
O2N64_RS04355	COG3409	Peptidoglycan-binding domain 1 protein
O2N64_RS04355	COG3773	Cell wall hydrolase
O2N64_RS04375	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O2N64_RS04380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O2N64_RS04385	COG0237	dephospho-CoA kinase activity
O2N64_RS04390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O2N64_RS04395	COG0424	maF-like protein
O2N64_RS04400	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
O2N64_RS04405	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O2N64_RS04410	COG1981	membrane
O2N64_RS04415	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
O2N64_RS04435	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
O2N64_RS04440	COG0445	tRNA wobble uridine modification
O2N64_RS04445	COG0357	Ribosomal RNA small subunit methyltransferase G
O2N64_RS04455	COG1475	DNA binding
O2N64_RS04465	COG1956	GAF domain-containing protein
O2N64_RS04480	COG0009	L-threonylcarbamoyladenylate synthase
O2N64_RS04495	COG1329	Transcriptional regulator
O2N64_RS04510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
O2N64_RS04515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O2N64_RS04525	COG0739	heme binding
O2N64_RS04530	COG0113	porphobilinogen synthase activity
O2N64_RS04545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O2N64_RS04550	COG1793	dna ligase
O2N64_RS04555	COG1793	dna ligase
O2N64_RS04555	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
O2N64_RS04585	COG0438	transferase activity, transferring glycosyl groups
O2N64_RS04600	COG0739	heme binding
O2N64_RS04605	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O2N64_RS04610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O2N64_RS04615	COG0799	negative regulation of ribosome biogenesis
O2N64_RS04625	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
O2N64_RS04635	COG0793	Belongs to the peptidase S41A family
O2N64_RS04645	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
O2N64_RS04655	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O2N64_RS04660	COG1295	ribonuclease BN
O2N64_RS04665	COG0484	heat shock protein binding
O2N64_RS04670	COG0259	pyridoxamine-phosphate oxidase activity
O2N64_RS04695	COG0482	sulfurtransferase activity
O2N64_RS04715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O2N64_RS04725	COG2733	membrane
O2N64_RS04740	COG2086	electron transfer activity
O2N64_RS04750	COG0045	succinate-CoA ligase (ADP-forming) activity
O2N64_RS04755	COG1218	3'(2'),5'-bisphosphate nucleotidase
O2N64_RS04765	COG1253	flavin adenine dinucleotide binding
O2N64_RS04770	COG3279	Response regulator of the LytR AlgR family
O2N64_RS04785	COG0501	Belongs to the peptidase M48B family
O2N64_RS04825	COG1473	amidohydrolase
O2N64_RS04845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O2N64_RS04860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O2N64_RS04870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O2N64_RS04885	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
O2N64_RS04890	COG1228	amidohydrolase
O2N64_RS04895	COG3104	oligopeptide transport
O2N64_RS04900	COG2188	Transcriptional regulator
O2N64_RS04905	COG0776	regulation of translation
O2N64_RS04920	COG4974	Belongs to the 'phage' integrase family
O2N64_RS04980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
O2N64_RS04980	COG0493	'glutamate synthase
O2N64_RS04995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O2N64_RS05005	COG4152	abc transporter atp-binding protein
O2N64_RS05010	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
O2N64_RS05020	COG2902	Dehydrogenase
O2N64_RS05035	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O2N64_RS05055	COG2957	Belongs to the agmatine deiminase family
O2N64_RS05065	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
O2N64_RS05070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O2N64_RS05075	COG2833	Protein of unknown function (DUF455)
O2N64_RS05080	COG0739	heme binding
O2N64_RS05085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O2N64_RS05115	COG0495	leucyl-tRNA aminoacylation
O2N64_RS05135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O2N64_RS05145	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O2N64_RS05165	COG0489	protein tyrosine kinase activity
O2N64_RS05165	COG3206	protein involved in exopolysaccharide biosynthesis
O2N64_RS05205	COG2226	methyltransferase
O2N64_RS05220	COG1088	dTDP-glucose 4,6-dehydratase activity
O2N64_RS05265	COG0367	asparagine synthase
O2N64_RS05295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O2N64_RS05300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O2N64_RS05310	COG2205	protein histidine kinase activity
O2N64_RS05325	COG1522	sequence-specific DNA binding
O2N64_RS05340	COG0067	glutamate synthase
O2N64_RS05340	COG0069	glutamate synthase activity
O2N64_RS05340	COG0070	glutamate synthase
O2N64_RS05355	COG0297	glycogen (starch) synthase activity
O2N64_RS05370	COG2755	lipolytic protein G-D-S-L family
O2N64_RS05370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
O2N64_RS05385	COG1132	(ABC) transporter
O2N64_RS05390	COG3590	peptidase
O2N64_RS05395	COG1968	undecaprenyl-diphosphatase activity
O2N64_RS05410	COG3186	Phenylalanine-4-hydroxylase
O2N64_RS05425	COG0514	ATP-dependent DNA helicase (RecQ)
O2N64_RS05450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O2N64_RS05455	COG0688	phosphatidylethanolamine metabolic process
O2N64_RS05470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O2N64_RS05470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O2N64_RS05485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
O2N64_RS05495	COG0564	pseudouridine synthase activity
O2N64_RS05505	COG0433	COG0433 Predicted ATPase
O2N64_RS05515	COG2205	protein histidine kinase activity
O2N64_RS05550	COG3706	GGDEF domain
O2N64_RS05555	COG0686	Belongs to the AlaDH PNT family
O2N64_RS05625	COG0189	ligase activity
O2N64_RS05630	COG0189	ligase activity
O2N64_RS05630	COG4067	protein conserved in archaea
O2N64_RS05655	COG0352	thiamine-phosphate diphosphorylase activity
O2N64_RS05660	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
O2N64_RS05680	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
O2N64_RS05685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O2N64_RS05700	COG1960	acyl-CoA dehydrogenase activity
O2N64_RS05715	COG3751	2OG-Fe(II) oxygenase superfamily
O2N64_RS05720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O2N64_RS05765	COG0628	permease
O2N64_RS05790	COG0519	Catalyzes the synthesis of GMP from XMP
O2N64_RS05790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O2N64_RS05800	COG1988	membrane-bound metal-dependent
O2N64_RS05810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O2N64_RS05820	COG2755	lipolytic protein G-D-S-L family
O2N64_RS05820	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
O2N64_RS05825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O2N64_RS05850	COG1131	(ABC) transporter
O2N64_RS05875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O2N64_RS05875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O2N64_RS05955	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O2N64_RS05980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O2N64_RS05995	COG2095	MarC family integral membrane protein
O2N64_RS06030	COG0469	pyruvate kinase activity
O2N64_RS06040	COG3750	Belongs to the UPF0335 family
O2N64_RS06050	COG0217	transcriptional regulatory protein
O2N64_RS06055	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
O2N64_RS06065	COG1393	Belongs to the ArsC family
O2N64_RS06070	COG0584	glycerophosphoryl diester phosphodiesterase
O2N64_RS06075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O2N64_RS06080	COG0527	aspartate kinase activity
O2N64_RS06085	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
O2N64_RS06105	COG2314	TM2 domain
O2N64_RS06120	COG0318	PFAM AMP-dependent synthetase and ligase
O2N64_RS06125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O2N64_RS06140	COG1218	3'(2'),5'-bisphosphate nucleotidase
O2N64_RS06150	COG0175	sulfate reduction
O2N64_RS06185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O2N64_RS06200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
O2N64_RS06250	COG1482	cell wall glycoprotein biosynthetic process
O2N64_RS06260	COG2267	carboxylic ester hydrolase activity
O2N64_RS06310	COG1758	RNA polymerase activity
O2N64_RS06315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O2N64_RS06330	COG5328	Belongs to the UPF0262 family
O2N64_RS06340	COG2866	Carboxypeptidase
O2N64_RS06355	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O2N64_RS06395	COG0230	Belongs to the bacterial ribosomal protein bL34 family
O2N64_RS06400	COG0594	ribonuclease P activity
O2N64_RS06405	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
O2N64_RS06410	COG0706	membrane insertase activity
O2N64_RS06415	COG0218	Necessary for normal cell division and for the maintenance of normal septation
O2N64_RS06420	COG5001	Diguanylate cyclase
O2N64_RS06430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O2N64_RS06435	COG1301	dicarboxylic acid transport
O2N64_RS06445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O2N64_RS06455	COG0501	Belongs to the peptidase M48B family
O2N64_RS06460	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O2N64_RS06465	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
O2N64_RS06475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O2N64_RS06485	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O2N64_RS06490	COG0268	Binds directly to 16S ribosomal RNA
O2N64_RS06495	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O2N64_RS06500	COG2226	methyltransferase
O2N64_RS06505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O2N64_RS06520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O2N64_RS06525	COG0756	dUTP diphosphatase activity
O2N64_RS06535	COG3710	Transcriptional regulator
O2N64_RS06545	COG0180	Tryptophanyl-tRNA synthetase
O2N64_RS06550	COG0728	peptidoglycan biosynthetic process
O2N64_RS06555	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
O2N64_RS06560	COG4395	Tim44
O2N64_RS06590	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
O2N64_RS06600	COG0450	alkyl hydroperoxide reductase
O2N64_RS06605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
O2N64_RS06610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O2N64_RS06615	COG0632	four-way junction helicase activity
O2N64_RS06635	COG2255	four-way junction helicase activity
O2N64_RS06670	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
O2N64_RS06685	COG2989	Protein conserved in bacteria
O2N64_RS06705	COG0123	including yeast histone deacetylase and acetoin utilization protein
O2N64_RS06715	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
O2N64_RS06725	COG0475	glutathione-regulated potassium exporter activity
O2N64_RS06725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O2N64_RS06730	COG2199	diguanylate cyclase activity
O2N64_RS06730	COG2200	EAL domain
O2N64_RS06755	COG0714	Associated with various cellular activities
O2N64_RS06770	COG0454	-acetyltransferase
O2N64_RS06775	COG0077	Prephenate dehydratase
O2N64_RS06775	COG1605	Chorismate mutase
O2N64_RS06780	COG3474	cytochrome
O2N64_RS06785	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
O2N64_RS06790	COG0248	Ppx GppA phosphatase
O2N64_RS06810	COG2226	methyltransferase
O2N64_RS06815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O2N64_RS06860	COG1611	Belongs to the LOG family
O2N64_RS06865	COG3920	Histidine kinase
O2N64_RS06880	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
O2N64_RS06880	COG0352	thiamine-phosphate diphosphorylase activity
O2N64_RS06880	COG0351	phosphomethylpyrimidine kinase
O2N64_RS06890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O2N64_RS06915	COG3920	Histidine kinase
O2N64_RS06915	COG2202	Pas domain
O2N64_RS06920	COG0725	ABC transporter, periplasmic molybdate-binding protein
O2N64_RS06925	COG4149	molybdate abc transporter
O2N64_RS06940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O2N64_RS06950	COG3119	arylsulfatase activity
O2N64_RS06960	COG3119	arylsulfatase activity
O2N64_RS06970	COG3119	arylsulfatase activity
O2N64_RS06975	COG3119	arylsulfatase activity
O2N64_RS06985	COG1609	Transcriptional regulator
O2N64_RS06990	COG1472	Belongs to the glycosyl hydrolase 3 family
O2N64_RS06995	COG3119	arylsulfatase activity
O2N64_RS07000	COG2814	Major facilitator Superfamily
O2N64_RS07005	COG1024	Enoyl-CoA hydratase
O2N64_RS07025	COG2365	Tyrosine phosphatase family
O2N64_RS07045	COG1028	Short-chain dehydrogenase reductase Sdr
O2N64_RS07050	COG1250	3-hydroxyacyl-CoA dehydrogenase
O2N64_RS07050	COG1024	Enoyl-CoA hydratase
O2N64_RS07055	COG1960	acyl-CoA dehydrogenase activity
O2N64_RS07070	COG1960	acyl-CoA dehydrogenase activity
O2N64_RS07075	COG1960	acyl-CoA dehydrogenase activity
O2N64_RS07080	COG0183	Belongs to the thiolase family
O2N64_RS07095	COG0318	PFAM AMP-dependent synthetase and ligase
O2N64_RS07110	COG1946	Acyl-CoA thioesterase
O2N64_RS07135	COG3727	T/G mismatch-specific endonuclease activity
O2N64_RS07155	COG0582	viral genome integration into host DNA
O2N64_RS07175	COG0745	RESPONSE REGULATOR receiver
O2N64_RS07180	COG0436	Aminotransferase
O2N64_RS07185	COG3243	poly(R)-hydroxyalkanoic acid synthase
O2N64_RS07195	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
O2N64_RS07220	COG0456	acetyltransferase
O2N64_RS07230	COG0784	Response regulator, receiver
O2N64_RS07235	COG0534	Mate efflux family protein
O2N64_RS07240	COG2080	2 iron, 2 sulfur cluster binding
O2N64_RS07245	COG4774	siderophore transport
O2N64_RS07250	COG1393	Belongs to the ArsC family
O2N64_RS07265	COG0321	lipoyl(octanoyl) transferase activity
O2N64_RS07305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O2N64_RS07310	COG4771	TonB-dependent receptor
O2N64_RS07315	COG0457	Tetratricopeptide repeat
O2N64_RS07335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O2N64_RS07355	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
O2N64_RS07370	COG0037	tRNA processing
O2N64_RS07385	COG0800	Aldolase
O2N64_RS07390	COG0837	glucose binding
O2N64_RS07395	COG0129	dihydroxy-acid dehydratase activity
O2N64_RS07400	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
O2N64_RS07410	COG0432	Pfam Uncharacterised protein family UPF0047
O2N64_RS07415	COG1228	amidohydrolase
O2N64_RS07420	COG1228	amidohydrolase
O2N64_RS07430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O2N64_RS07445	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
O2N64_RS07450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O2N64_RS07460	COG1609	Transcriptional regulator
O2N64_RS07470	COG4771	TonB-dependent receptor
O2N64_RS07475	COG1621	beta-fructofuranosidase activity
O2N64_RS07480	COG1940	carbohydrate kinase activity
O2N64_RS07490	COG0616	signal peptide processing
O2N64_RS07495	COG0540	Belongs to the ATCase OTCase family
O2N64_RS07500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O2N64_RS07505	COG1028	Short-chain dehydrogenase reductase Sdr
O2N64_RS07530	COG2311	Membrane
O2N64_RS07550	COG1160	GTP binding
O2N64_RS07565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O2N64_RS07580	COG3023	N-Acetylmuramoyl-L-alanine amidase
O2N64_RS07595	COG0564	pseudouridine synthase activity
O2N64_RS07600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O2N64_RS07605	COG0297	glycogen (starch) synthase activity
O2N64_RS07615	COG1230	cation diffusion facilitator family transporter
O2N64_RS07625	COG1595	DNA-templated transcription, initiation
O2N64_RS07635	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
O2N64_RS07650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O2N64_RS07655	COG0740	serine-type endopeptidase activity
O2N64_RS07670	COG0154	amidase activity
O2N64_RS07680	COG0544	peptidyl-prolyl cis-trans isomerase activity
O2N64_RS07695	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O2N64_RS07710	COG0730	response to heat
O2N64_RS07725	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O2N64_RS07735	COG0525	valine-tRNA ligase activity
O2N64_RS07740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O2N64_RS07770	COG0546	phosphoglycolate phosphatase activity
O2N64_RS07780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O2N64_RS07785	COG0828	Belongs to the bacterial ribosomal protein bS21 family
O2N64_RS07800	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O2N64_RS07805	COG0154	amidase activity
O2N64_RS07820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O2N64_RS07825	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O2N64_RS07825	COG3743	rRNA binding
O2N64_RS07840	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O2N64_RS07850	COG0612	Peptidase, M16
O2N64_RS07875	COG4771	TonB-dependent receptor
O2N64_RS07885	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
O2N64_RS07915	COG4964	Belongs to the GSP D family
O2N64_RS07930	COG2267	carboxylic ester hydrolase activity
O2N64_RS07940	COG3422	double-strand break repair
O2N64_RS07945	COG0328	RNA-DNA hybrid ribonuclease activity
O2N64_RS07950	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O2N64_RS07955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O2N64_RS07965	COG0018	arginyl-trna synthetase
O2N64_RS07980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
O2N64_RS07985	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
O2N64_RS07990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O2N64_RS07995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O2N64_RS08000	COG0805	protein transport
O2N64_RS08010	COG1574	metal-dependent hydrolase with the TIM-barrel fold
O2N64_RS08015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O2N64_RS08020	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
O2N64_RS08025	COG0729	surface antigen
O2N64_RS08055	COG1476	TRANSCRIPTIONal
O2N64_RS08070	COG0174	glutamine synthetase
O2N64_RS08075	COG0347	Belongs to the P(II) protein family
O2N64_RS08090	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O2N64_RS08100	COG0024	Methionine aminopeptidase
O2N64_RS08110	COG0739	heme binding
O2N64_RS08135	COG4964	Belongs to the GSP D family
O2N64_RS08215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O2N64_RS08235	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O2N64_RS08240	COG4133	protoheme IX ABC transporter activity
O2N64_RS08245	COG2154	pterin-4-alpha-carbinolamine dehydratase
O2N64_RS08255	COG1064	alcohol dehydrogenase
O2N64_RS08260	COG4221	oxidoreductase activity
O2N64_RS08265	COG1028	Short-chain dehydrogenase reductase Sdr
O2N64_RS08285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O2N64_RS08300	COG2001	Belongs to the MraZ family
O2N64_RS08305	COG0275	rRNA processing
O2N64_RS08320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O2N64_RS08325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O2N64_RS08330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O2N64_RS08335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O2N64_RS08345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O2N64_RS08350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O2N64_RS08355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O2N64_RS08360	COG1181	Belongs to the D-alanine--D-alanine ligase family
O2N64_RS08365	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O2N64_RS08370	COG0849	cell division
O2N64_RS08390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O2N64_RS08395	COG0670	Belongs to the BI1 family
O2N64_RS08405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
O2N64_RS08410	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O2N64_RS08415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O2N64_RS08430	COG0175	sulfate reduction
O2N64_RS08440	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O2N64_RS08450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O2N64_RS08450	COG1648	precorrin-2 dehydrogenase activity
O2N64_RS08455	COG3264	Mechanosensitive ion channel
O2N64_RS08455	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
O2N64_RS08460	COG0626	cystathionine gamma-synthase activity
O2N64_RS08470	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O2N64_RS08475	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O2N64_RS08500	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O2N64_RS08505	COG1695	Transcriptional regulator
O2N64_RS08515	COG0438	transferase activity, transferring glycosyl groups
O2N64_RS08535	COG4232	protein-disulfide reductase activity
O2N64_RS08540	COG0785	Cytochrome C biogenesis protein
O2N64_RS08560	COG1217	gtp-binding protein TYPA
O2N64_RS08565	COG4771	TonB-dependent receptor
O2N64_RS08570	COG1714	RDD family
O2N64_RS08580	COG4181	ATPase activity
O2N64_RS08585	COG2755	lipolytic protein G-D-S-L family
O2N64_RS08590	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O2N64_RS08620	COG1012	belongs to the aldehyde dehydrogenase family
O2N64_RS08635	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
O2N64_RS08650	COG0066	3-isopropylmalate dehydratase activity
O2N64_RS08665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O2N64_RS08700	COG2166	iron-sulfur cluster assembly
O2N64_RS08750	COG1842	Phage shock protein A
O2N64_RS08760	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
O2N64_RS08780	COG0779	Required for maturation of 30S ribosomal subunits
O2N64_RS08795	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
O2N64_RS08810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O2N64_RS08815	COG1435	thymidine kinase activity
O2N64_RS08825	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
O2N64_RS08830	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
O2N64_RS08835	COG0477	Major facilitator Superfamily
O2N64_RS08865	COG3507	Belongs to the glycosyl hydrolase 43 family
O2N64_RS08865	COG2382	esterase
O2N64_RS08865	COG3693	PFAM glycoside hydrolase, family 10
O2N64_RS08870	COG1472	Belongs to the glycosyl hydrolase 3 family
O2N64_RS08880	COG0129	dihydroxy-acid dehydratase activity
O2N64_RS08900	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
O2N64_RS08910	COG1472	Belongs to the glycosyl hydrolase 3 family
O2N64_RS08915	COG1994	Peptidase M50
O2N64_RS08920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
O2N64_RS08925	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O2N64_RS08930	COG1185	polyribonucleotide nucleotidyltransferase activity
O2N64_RS08945	COG1064	alcohol dehydrogenase
O2N64_RS08970	COG0842	Transport permease protein
O2N64_RS09020	COG1028	Short-chain dehydrogenase reductase Sdr
O2N64_RS09025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O2N64_RS09045	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
O2N64_RS09060	COG1609	Transcriptional regulator
O2N64_RS09070	COG1028	Short-chain dehydrogenase reductase Sdr
O2N64_RS09085	COG3268	Saccharopine dehydrogenase
O2N64_RS09100	COG0745	RESPONSE REGULATOR receiver
O2N64_RS09105	COG2201	protein-glutamate methylesterase activity
O2N64_RS09110	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O2N64_RS09115	COG5001	Diguanylate cyclase
O2N64_RS09130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O2N64_RS09135	COG0737	Belongs to the 5'-nucleotidase family
O2N64_RS09150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O2N64_RS09175	COG1228	amidohydrolase
O2N64_RS09195	COG1132	(ABC) transporter
O2N64_RS09200	COG4566	intracellular signal transduction
O2N64_RS09205	COG0572	uridine kinase
O2N64_RS09215	COG0494	nUDIX hydrolase
O2N64_RS09225	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
O2N64_RS09235	COG1970	mechanosensitive ion channel activity
O2N64_RS09240	COG1970	mechanosensitive ion channel activity
O2N64_RS09255	COG3724	N-succinylarginine dihydrolase activity
O2N64_RS09275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O2N64_RS09280	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
O2N64_RS09285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O2N64_RS09290	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
O2N64_RS09295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O2N64_RS09315	COG0105	UTP biosynthetic process
O2N64_RS09330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
O2N64_RS09335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O2N64_RS09350	COG1045	serine acetyltransferase
O2N64_RS09370	COG0546	phosphoglycolate phosphatase activity
O2N64_RS09375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
O2N64_RS09385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O2N64_RS09390	COG5001	Diguanylate cyclase
O2N64_RS09395	COG0047	phosphoribosylformylglycinamidine synthase activity
O2N64_RS09400	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O2N64_RS09405	COG0612	Peptidase, M16
O2N64_RS09415	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O2N64_RS09445	COG0424	maF-like protein
O2N64_RS09450	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
O2N64_RS09460	COG2081	HI0933 family
O2N64_RS09465	COG0531	amino acid
O2N64_RS09470	COG0322	excinuclease ABC activity
O2N64_RS09485	COG1946	Acyl-CoA thioesterase
O2N64_RS09500	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
O2N64_RS09505	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
O2N64_RS09510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O2N64_RS09515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O2N64_RS09520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O2N64_RS09530	COG0596	Alpha beta hydrolase
O2N64_RS09535	COG0545	Peptidyl-prolyl cis-trans isomerase
O2N64_RS09540	COG1741	Belongs to the pirin family
O2N64_RS09580	COG2234	aminopeptidase activity
O2N64_RS09585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O2N64_RS09600	COG0101	tRNA pseudouridine synthase activity
O2N64_RS09605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O2N64_RS09610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
O2N64_RS09615	COG0242	peptide deformylase activity
O2N64_RS09635	COG1322	Protein conserved in bacteria
O2N64_RS09640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O2N64_RS09650	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O2N64_RS09650	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
O2N64_RS09655	COG1660	Displays ATPase and GTPase activities
O2N64_RS09665	COG2205	protein histidine kinase activity
O2N64_RS09670	COG0745	RESPONSE REGULATOR receiver
O2N64_RS09675	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
O2N64_RS09710	COG2945	thiolester hydrolase activity
O2N64_RS09715	COG1104	cysteine desulfurase activity
O2N64_RS09720	COG1104	cysteine desulfurase activity
O2N64_RS09755	COG0693	protein deglycase activity
O2N64_RS09760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O2N64_RS09770	COG0617	tRNA 3'-terminal CCA addition
O2N64_RS09790	COG2133	pyrroloquinoline quinone binding
O2N64_RS09795	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O2N64_RS09815	COG2189	Belongs to the N(4) N(6)-methyltransferase family
O2N64_RS09825	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O2N64_RS09860	COG1794	racemase activity, acting on amino acids and derivatives
O2N64_RS09865	COG0232	Belongs to the dGTPase family. Type 2 subfamily
O2N64_RS09905	COG0438	transferase activity, transferring glycosyl groups
O2N64_RS09945	COG1505	serine-type exopeptidase activity
O2N64_RS09955	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O2N64_RS09960	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O2N64_RS09970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O2N64_RS09975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O2N64_RS09980	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O2N64_RS09995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O2N64_RS09995	COG2169	Transcriptional regulator
O2N64_RS10000	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
O2N64_RS10020	COG3046	protein related to deoxyribodipyrimidine photolyase
O2N64_RS10030	COG1410	methionine synthase
O2N64_RS10030	COG0646	methionine synthase
O2N64_RS10035	COG1410	methionine synthase
O2N64_RS10035	COG0646	methionine synthase
O2N64_RS10045	COG2226	methyltransferase
O2N64_RS10050	COG3920	Histidine kinase
O2N64_RS10085	COG0215	cysteine-tRNA ligase activity
O2N64_RS10090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O2N64_RS10100	COG1012	belongs to the aldehyde dehydrogenase family
O2N64_RS10130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O2N64_RS10145	COG0333	Belongs to the bacterial ribosomal protein bL32 family
O2N64_RS10150	COG0416	fatty acid biosynthetic process
O2N64_RS10155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O2N64_RS10160	COG0776	regulation of translation
O2N64_RS10185	COG1199	ATP-dependent helicase activity
O2N64_RS10205	COG0668	transmembrane transport
O2N64_RS10210	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
O2N64_RS10240	COG2264	protein methyltransferase activity
O2N64_RS10245	COG1047	Peptidyl-prolyl cis-trans
O2N64_RS10280	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
O2N64_RS10315	COG1609	Transcriptional regulator
O2N64_RS10325	COG2205	protein histidine kinase activity
O2N64_RS10325	COG2202	Pas domain
O2N64_RS10330	COG1522	sequence-specific DNA binding
O2N64_RS10345	COG0439	Biotin carboxylase
O2N64_RS10355	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O2N64_RS10375	COG1862	Preprotein translocase
O2N64_RS10380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O2N64_RS10385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O2N64_RS10390	COG0438	transferase activity, transferring glycosyl groups
O2N64_RS10410	COG0488	(ABC) transporter
O2N64_RS10440	COG1605	Chorismate mutase
O2N64_RS10440	COG0287	Prephenate dehydrogenase
O2N64_RS10445	COG0142	geranyltranstransferase activity
O2N64_RS10455	COG1643	Atp-dependent helicase
O2N64_RS10475	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
O2N64_RS10485	COG0235	Class ii aldolase
O2N64_RS10505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O2N64_RS10515	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
O2N64_RS10530	COG3800	Transcriptional regulator
O2N64_RS10530	COG1396	sequence-specific DNA binding
O2N64_RS10535	COG0688	phosphatidylethanolamine metabolic process
O2N64_RS10545	COG0052	Belongs to the universal ribosomal protein uS2 family
O2N64_RS10550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
O2N64_RS10560	COG0528	UMP kinase activity
O2N64_RS10565	COG0233	cytoplasmic translational termination
O2N64_RS10570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O2N64_RS10580	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
O2N64_RS10585	COG0750	zinc metalloprotease
O2N64_RS10590	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O2N64_RS10600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O2N64_RS10605	COG0254	rRNA binding
O2N64_RS10630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O2N64_RS10635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O2N64_RS10645	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
O2N64_RS10650	COG1138	Cytochrome C-type biogenesis protein
O2N64_RS10655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O2N64_RS10670	COG3158	transport of potassium into the cell
O2N64_RS10675	COG0531	amino acid
O2N64_RS10685	COG2917	probably involved in intracellular septation
O2N64_RS10690	COG0552	protein localization to endoplasmic reticulum
O2N64_RS10695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O2N64_RS10700	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O2N64_RS10705	COG5001	Diguanylate cyclase
O2N64_RS10705	COG3300	MHYT domain
O2N64_RS10715	COG3237	CsbD-like
O2N64_RS10720	COG1028	Short-chain dehydrogenase reductase Sdr
O2N64_RS10725	COG0028	Belongs to the TPP enzyme family
O2N64_RS10740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O2N64_RS10755	COG0583	DNA-binding transcription factor activity
O2N64_RS10760	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
O2N64_RS10765	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O2N64_RS10780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O2N64_RS10785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O2N64_RS10790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O2N64_RS10835	COG1877	trehalose-phosphatase activity
O2N64_RS10840	COG3387	PFAM Glycoside hydrolase 15-related
O2N64_RS10845	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
O2N64_RS10850	COG0745	RESPONSE REGULATOR receiver
O2N64_RS10870	COG1899	peptidyl-lysine modification to peptidyl-hypusine
O2N64_RS10895	COG5001	Diguanylate cyclase
O2N64_RS10895	COG3300	MHYT domain
O2N64_RS10900	COG0156	8-amino-7-oxononanoate synthase activity
O2N64_RS10905	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O2N64_RS10910	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
O2N64_RS10915	COG0758	DNA mediated transformation
O2N64_RS10930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O2N64_RS10930	COG1754	DNA topoisomerase type I activity
O2N64_RS10945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
O2N64_RS10950	COG0571	ribonuclease III activity
O2N64_RS10960	COG0166	Belongs to the GPI family
O2N64_RS10965	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
O2N64_RS10975	COG0513	Belongs to the DEAD box helicase family
O2N64_RS10995	COG3655	Transcriptional regulator
O2N64_RS11015	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O2N64_RS11020	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O2N64_RS11030	COG4974	Belongs to the 'phage' integrase family
O2N64_RS11035	COG0825	malonyl-CoA metabolic process
O2N64_RS11040	COG4783	chaperone-mediated protein folding
O2N64_RS11070	COG0302	gtp cyclohydrolase
O2N64_RS11090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
O2N64_RS11090	COG0678	peroxiredoxin activity
O2N64_RS11095	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
O2N64_RS11100	COG2205	protein histidine kinase activity
O2N64_RS11105	COG0802	atpase or kinase
O2N64_RS11110	COG3178	'Phosphotransferase
O2N64_RS11115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
O2N64_RS11125	COG1074	ATP-dependent DNA helicase activity
O2N64_RS11135	COG0483	inositol monophosphate 1-phosphatase activity
O2N64_RS11140	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
O2N64_RS11150	COG0653	protein targeting
O2N64_RS11170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O2N64_RS11185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
O2N64_RS11195	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O2N64_RS11215	COG1136	(ABC) transporter
O2N64_RS11240	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
O2N64_RS11240	COG2885	chlorophyll binding
O2N64_RS11250	COG0521	Mo-molybdopterin cofactor biosynthetic process
O2N64_RS11270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O2N64_RS11280	COG0129	dihydroxy-acid dehydratase activity
O2N64_RS11290	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
O2N64_RS11290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
O2N64_RS11295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O2N64_RS11350	COG3409	Peptidoglycan-binding domain 1 protein
O2N64_RS11350	COG3267	Type II secretory pathway component ExeA
O2N64_RS11375	COG0367	asparagine synthase
O2N64_RS11380	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
O2N64_RS11405	COG1530	ribonuclease E activity
O2N64_RS11415	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
O2N64_RS11450	COG0004	ammonium transporteR
O2N64_RS11465	COG0183	Belongs to the thiolase family
O2N64_RS11470	COG1012	belongs to the aldehyde dehydrogenase family
O2N64_RS11480	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O2N64_RS11485	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O2N64_RS11490	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O2N64_RS11495	COG0649	NAD binding
O2N64_RS11510	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
O2N64_RS11525	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
O2N64_RS11550	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
O2N64_RS11555	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O2N64_RS11565	COG0713	ATP synthesis coupled electron transport
O2N64_RS11580	COG1007	ATP synthesis coupled electron transport
O2N64_RS11590	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
O2N64_RS11625	COG2205	protein histidine kinase activity
O2N64_RS11630	COG0372	Belongs to the citrate synthase family
O2N64_RS11635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O2N64_RS11640	COG0658	competence protein
O2N64_RS11640	COG2333	competence protein COMEC
O2N64_RS11645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O2N64_RS11650	COG0303	'Molybdopterin
O2N64_RS11655	COG0315	cyclic pyranopterin monophosphate synthase activity
O2N64_RS11665	COG0134	indole-3-glycerol-phosphate synthase activity
O2N64_RS11670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O2N64_RS11685	COG3698	Phosphodiester glycosidase
O2N64_RS11690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O2N64_RS11700	COG0149	triose-phosphate isomerase activity
O2N64_RS11710	COG0504	CTP synthase activity
O2N64_RS11715	COG0071	Belongs to the small heat shock protein (HSP20) family
O2N64_RS11720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
O2N64_RS11725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O2N64_RS11750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O2N64_RS11755	COG0508	dehydrogenase complex catalyzes the overall conversion of
O2N64_RS11755	COG0022	dehydrogenase e1 component
O2N64_RS11800	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
O2N64_RS11815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O2N64_RS11830	COG0012	GTP binding
O2N64_RS11850	COG0193	aminoacyl-tRNA hydrolase activity
O2N64_RS11855	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O2N64_RS11910	COG0752	glycyl-tRNA synthetase alpha subunit
O2N64_RS11915	COG0751	glycine-tRNA ligase activity
O2N64_RS11920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O2N64_RS11920	COG0574	Belongs to the PEP-utilizing enzyme family
O2N64_RS11930	COG1040	competence protein
O2N64_RS11935	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O2N64_RS11960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O2N64_RS11970	COG3876	Protein conserved in bacteria
O2N64_RS11980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O2N64_RS11985	COG3739	integral membrane protein
O2N64_RS11990	COG0187	DNA topoisomerase II activity
O2N64_RS12000	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
O2N64_RS12005	COG0792	nuclease activity
O2N64_RS12010	COG0189	ligase activity
O2N64_RS12020	COG0586	Pfam SNARE associated Golgi protein
O2N64_RS12030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O2N64_RS12035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O2N64_RS12040	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
O2N64_RS12045	COG1420	regulation of RNA biosynthetic process
O2N64_RS12050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O2N64_RS12075	COG2847	Copper chaperone PCu(A)C
O2N64_RS12080	COG0443	Heat shock 70 kDa protein
O2N64_RS12085	COG0484	heat shock protein binding
O2N64_RS12090	COG1752	Esterase of the alpha-beta hydrolase superfamily
O2N64_RS12120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O2N64_RS12130	COG0442	prolyl-tRNA aminoacylation
O2N64_RS12140	COG2234	aminopeptidase activity
O2N64_RS12145	COG0557	exoribonuclease II activity
O2N64_RS12160	COG0508	dehydrogenase complex catalyzes the overall conversion of
O2N64_RS12170	COG1607	acyl-coa hydrolase
O2N64_RS12175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O2N64_RS12200	COG2951	lytic endotransglycosylase activity
O2N64_RS12210	COG1686	Belongs to the peptidase S11 family
O2N64_RS12215	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O2N64_RS12220	COG0470	DNA polymerase III
O2N64_RS12230	COG0084	hydrolase, TatD family'
O2N64_RS12235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
O2N64_RS12235	COG0321	lipoyl(octanoyl) transferase activity
O2N64_RS12245	COG3956	TIGRFAM MazG family protein
O2N64_RS12250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O2N64_RS12255	COG1923	regulation of RNA biosynthetic process
O2N64_RS12260	COG2204	response regulator
O2N64_RS12265	COG5000	phosphorelay sensor kinase activity
O2N64_RS12270	COG2204	response regulator
O2N64_RS12275	COG3852	Histidine kinase
O2N64_RS12285	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
O2N64_RS12285	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O2N64_RS12290	COG1058	Belongs to the CinA family
O2N64_RS12290	COG1546	Belongs to the CinA family
O2N64_RS12295	COG2867	negative regulation of translational initiation
O2N64_RS12300	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
O2N64_RS12315	COG0288	reversible hydration of carbon dioxide
O2N64_RS12345	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O2N64_RS12370	COG0772	Belongs to the SEDS family
O2N64_RS12450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O2N64_RS12460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
O2N64_RS12465	COG0148	phosphopyruvate hydratase activity
O2N64_RS12495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O2N64_RS12515	COG0505	Belongs to the CarA family
O2N64_RS12530	COG0358	DNA primase activity
O2N64_RS12535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O2N64_RS12560	COG0698	ribose 5-phosphate isomerase
O2N64_RS12565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O2N64_RS12575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O2N64_RS12590	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O2N64_RS12610	COG0343	queuine tRNA-ribosyltransferase activity
O2N64_RS12625	COG0842	Transport permease protein
O2N64_RS12630	COG1131	(ABC) transporter
O2N64_RS12635	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
O2N64_RS12645	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O2N64_RS12650	COG0142	geranyltranstransferase activity
O2N64_RS12655	COG1722	exodeoxyribonuclease VII activity
O2N64_RS12665	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O2N64_RS12685	COG0560	Phosphoserine phosphatase
O2N64_RS12690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O2N64_RS12695	COG0028	Belongs to the TPP enzyme family
O2N64_RS12710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O2N64_RS12725	COG2353	YceI-like domain
O2N64_RS12730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O2N64_RS12735	COG0784	Response regulator, receiver
O2N64_RS12735	COG2205	protein histidine kinase activity
O2N64_RS12750	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
O2N64_RS12760	COG5002	protein histidine kinase activity
O2N64_RS12765	COG3746	phosphate-selective porin O and P
O2N64_RS12775	COG0573	inorganic phosphate transmembrane transporter activity
O2N64_RS12785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O2N64_RS12790	COG0704	Plays a role in the regulation of phosphate uptake
O2N64_RS12795	COG0745	RESPONSE REGULATOR receiver
O2N64_RS12810	COG0587	DNA-directed DNA polymerase activity
O2N64_RS12835	COG1253	flavin adenine dinucleotide binding
O2N64_RS12860	COG0733	neurotransmitter:sodium symporter activity
O2N64_RS12865	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
O2N64_RS12880	COG2204	response regulator
O2N64_RS12885	COG4191	Histidine kinase
O2N64_RS12890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O2N64_RS12900	COG3273	potassium ion transport
O2N64_RS12900	COG0471	metal ion transport
O2N64_RS12915	COG0483	inositol monophosphate 1-phosphatase activity
O2N64_RS12920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O2N64_RS12930	COG4942	peptidase
O2N64_RS12935	COG1376	ErfK ybiS ycfS ynhG family protein
O2N64_RS12940	COG0352	thiamine-phosphate diphosphorylase activity
O2N64_RS12945	COG3588	fructose-bisphosphate aldolase
O2N64_RS12960	COG0126	phosphoglycerate kinase activity
O2N64_RS12965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O2N64_RS12990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O2N64_RS13000	COG0824	Thioesterase
O2N64_RS13005	COG1454	alcohol dehydrogenase
O2N64_RS13035	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O2N64_RS13060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O2N64_RS13065	COG0463	Glycosyl transferase, family 2
O2N64_RS13105	COG0438	transferase activity, transferring glycosyl groups
O2N64_RS13125	COG3206	protein involved in exopolysaccharide biosynthesis
O2N64_RS13125	COG0489	protein tyrosine kinase activity
O2N64_RS13135	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
O2N64_RS13140	COG1028	Short-chain dehydrogenase reductase Sdr
O2N64_RS13155	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
O2N64_RS13160	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
O2N64_RS13175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O2N64_RS13180	COG0415	Belongs to the DNA photolyase family
O2N64_RS13190	COG0110	maltose O-acetyltransferase activity
O2N64_RS13200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O2N64_RS13205	COG1902	pentaerythritol trinitrate reductase activity
O2N64_RS13210	COG1013	pyruvate-flavodoxin oxidoreductase activity
O2N64_RS13215	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
O2N64_RS13215	COG0674	pyruvate-flavodoxin oxidoreductase activity
O2N64_RS13220	COG1051	belongs to the nudix hydrolase family
O2N64_RS13230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O2N64_RS13245	COG1028	Short-chain dehydrogenase reductase Sdr
O2N64_RS13250	COG2321	neutral zinc metallopeptidase
O2N64_RS13265	COG1595	DNA-templated transcription, initiation
O2N64_RS13280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O2N64_RS13310	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
O2N64_RS13320	COG1028	Short-chain dehydrogenase reductase Sdr
O2N64_RS13330	COG2264	protein methyltransferase activity
O2N64_RS13340	COG4221	oxidoreductase activity
O2N64_RS13345	COG4941	Belongs to the sigma-70 factor family
O2N64_RS13350	COG3795	YCII-related domain
O2N64_RS13355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O2N64_RS13380	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O2N64_RS13425	COG0481	GTPase activity
O2N64_RS13430	COG5001	Diguanylate cyclase
O2N64_RS13435	COG5001	Diguanylate cyclase
O2N64_RS13435	COG3300	MHYT domain
O2N64_RS13440	COG0493	'glutamate synthase
O2N64_RS13480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O2N64_RS13490	COG2354	Protein conserved in bacteria
O2N64_RS13495	COG0360	Binds together with S18 to 16S ribosomal RNA
O2N64_RS13500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O2N64_RS13505	COG0359	binds to the 23S rRNA
O2N64_RS13550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O2N64_RS13560	COG0335	large ribosomal subunit rRNA binding
O2N64_RS13565	COG0336	Belongs to the RNA methyltransferase TrmD family
O2N64_RS13590	COG0492	ferredoxin-NADP+ reductase activity
O2N64_RS13600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O2N64_RS13605	COG0228	four-way junction DNA binding
O2N64_RS13610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
O2N64_RS13625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O2N64_RS13645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O2N64_RS13655	COG0539	negative regulation of cytoplasmic translation
O2N64_RS13660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O2N64_RS13670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O2N64_RS13675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O2N64_RS13680	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O2N64_RS13685	COG0356	it plays a direct role in the translocation of protons across the membrane
O2N64_RS13715	COG2003	Belongs to the UPF0758 family
O2N64_RS13725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O2N64_RS13735	COG0284	orotidine-5'-phosphate decarboxylase activity
O2N64_RS13745	COG0135	phosphoribosylanthranilate isomerase activity
O2N64_RS13750	COG0133	tryptophan synthase activity
O2N64_RS13755	COG0159	tryptophan synthase activity
O2N64_RS13760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
O2N64_RS13765	COG0285	dihydrofolate synthase activity
O2N64_RS13770	COG2223	nitrite transmembrane transporter activity
O2N64_RS13775	COG1187	pseudouridine synthase activity
O2N64_RS13780	COG0742	ribosomal rna small subunit methyltransferase
O2N64_RS13790	COG0210	DNA helicase
O2N64_RS13845	COG0318	PFAM AMP-dependent synthetase and ligase
O2N64_RS13850	COG0183	Belongs to the thiolase family
O2N64_RS13855	COG1024	Enoyl-CoA hydratase
O2N64_RS13855	COG1250	3-hydroxyacyl-CoA dehydrogenase
O2N64_RS13860	COG1960	acyl-CoA dehydrogenase activity
O2N64_RS13880	COG0644	oxidoreductase
O2N64_RS13885	COG0538	isocitrate dehydrogenase activity
O2N64_RS13890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O2N64_RS13890	COG3153	acetyltransferase
O2N64_RS13900	COG1278	Cold shock
O2N64_RS13905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O2N64_RS13910	COG0475	glutathione-regulated potassium exporter activity
O2N64_RS13910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O2N64_RS13920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O2N64_RS13925	COG4106	trans-aconitate 2-methyltransferase activity
O2N64_RS13930	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O2N64_RS13955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O2N64_RS13970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O2N64_RS13975	COG0741	lytic transglycosylase activity
O2N64_RS14005	COG2268	Band 7 protein
O2N64_RS14020	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O2N64_RS14025	COG2311	Membrane
O2N64_RS14030	COG0500	methyltransferase
O2N64_RS14030	COG3615	Tellurite resistance protein tehB
O2N64_RS14050	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
O2N64_RS14055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O2N64_RS14065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O2N64_RS14070	COG0534	Mate efflux family protein
O2N64_RS14085	COG0137	argininosuccinate synthase activity
O2N64_RS14090	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
O2N64_RS14120	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O2N64_RS14155	COG0339	signal peptide processing
O2N64_RS14165	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
O2N64_RS14170	COG4139	cobalamin transport
O2N64_RS14180	COG4771	TonB-dependent receptor
O2N64_RS14195	COG5001	Diguanylate cyclase
O2N64_RS14200	COG0039	L-malate dehydrogenase activity
O2N64_RS14210	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
O2N64_RS14215	COG0567	Dehydrogenase, E1 component
O2N64_RS14220	COG0508	dehydrogenase complex catalyzes the overall conversion of
O2N64_RS14225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O2N64_RS14265	COG1505	serine-type exopeptidase activity
O2N64_RS14275	COG0203	ribosomal protein L17
O2N64_RS14280	COG0202	RNA polymerase activity
O2N64_RS14285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O2N64_RS14290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
O2N64_RS14300	COG0563	adenylate kinase activity
O2N64_RS14305	COG0201	protein transport
O2N64_RS14310	COG0200	Binds to the 23S rRNA
O2N64_RS14315	COG1841	ribosomal large subunit assembly
O2N64_RS14320	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
O2N64_RS14325	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
O2N64_RS14330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
O2N64_RS14335	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O2N64_RS14340	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O2N64_RS14345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O2N64_RS14350	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
O2N64_RS14355	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
O2N64_RS14365	COG0255	Belongs to the universal ribosomal protein uL29 family
O2N64_RS14370	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
O2N64_RS14375	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
O2N64_RS14380	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
O2N64_RS14385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
O2N64_RS14390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O2N64_RS14395	COG0089	rRNA binding