locus-tag	class	description
AURMO_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AURMO_RS00010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AURMO_RS00020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AURMO_RS00025	COG0706	membrane insertase activity
AURMO_RS00035	COG0357	Ribosomal RNA small subunit methyltransferase G
AURMO_RS00040	COG1192	Involved in chromosome partitioning
AURMO_RS00050	COG1181	Belongs to the D-alanine--D-alanine ligase family
AURMO_RS00055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AURMO_RS00060	COG3118	belongs to the thioredoxin family
AURMO_RS00065	COG0492	ferredoxin-NADP+ reductase activity
AURMO_RS00075	COG0617	tRNA 3'-terminal CCA addition
AURMO_RS00080	COG0360	Binds together with S18 to 16S ribosomal RNA
AURMO_RS00090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AURMO_RS00095	COG0359	binds to the 23S rRNA
AURMO_RS00100	COG0305	Participates in initiation and elongation during chromosome replication
AURMO_RS00115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AURMO_RS00140	COG0022	dehydrogenase e1 component
AURMO_RS00145	COG0508	dehydrogenase complex catalyzes the overall conversion of
AURMO_RS00150	COG3177	Filamentation induced by cAMP protein fic
AURMO_RS00155	COG1280	lysine exporter protein (LysE YggA)
AURMO_RS00165	COG1522	sequence-specific DNA binding
AURMO_RS00170	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AURMO_RS00230	COG2814	Major facilitator Superfamily
AURMO_RS00240	COG1028	Short-chain dehydrogenase reductase Sdr
AURMO_RS00265	COG1129	ABC transporter
AURMO_RS00270	COG1172	Belongs to the binding-protein-dependent transport system permease family
AURMO_RS00285	COG1012	belongs to the aldehyde dehydrogenase family
AURMO_RS00310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AURMO_RS00315	COG1492	cobalamin metabolic process
AURMO_RS00320	COG3104	oligopeptide transport
AURMO_RS00325	COG2267	carboxylic ester hydrolase activity
AURMO_RS00335	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AURMO_RS00350	COG1132	(ABC) transporter
AURMO_RS00365	COG1216	Glycosyl transferase, family 2
AURMO_RS00385	COG0477	Major facilitator Superfamily
AURMO_RS00390	COG1733	regulation of RNA biosynthetic process
AURMO_RS00405	COG0077	Prephenate dehydratase
AURMO_RS00410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AURMO_RS00415	COG0561	phosphatase activity
AURMO_RS00425	COG1316	TRANSCRIPTIONal
AURMO_RS00435	COG0513	Belongs to the DEAD box helicase family
AURMO_RS00445	COG1960	acyl-CoA dehydrogenase activity
AURMO_RS00465	COG2326	polyphosphate kinase activity
AURMO_RS00475	COG0646	methionine synthase
AURMO_RS00475	COG1410	methionine synthase
AURMO_RS00490	COG3845	ABC transporter
AURMO_RS00515	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AURMO_RS00530	COG0181	hydroxymethylbilane synthase activity
AURMO_RS00535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AURMO_RS00540	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AURMO_RS00550	COG3253	May function as heme-dependent peroxidase
AURMO_RS00555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AURMO_RS00585	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AURMO_RS00590	COG0037	tRNA processing
AURMO_RS00600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AURMO_RS00605	COG0302	gtp cyclohydrolase
AURMO_RS00615	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AURMO_RS00620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AURMO_RS00635	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AURMO_RS00640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AURMO_RS00650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AURMO_RS00655	COG0667	Aldo Keto reductase
AURMO_RS00685	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AURMO_RS00710	COG2184	nucleotidyltransferase activity
AURMO_RS00730	COG2197	response regulator
AURMO_RS00735	COG4585	Histidine kinase
AURMO_RS00740	COG1136	(ABC) transporter
AURMO_RS00745	COG0577	efflux transmembrane transporter activity
AURMO_RS00745	COG1136	(ABC) transporter
AURMO_RS00765	COG2197	response regulator
AURMO_RS00850	COG0085	RNA polymerase activity
AURMO_RS00855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AURMO_RS00865	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AURMO_RS00870	COG0049	tRNA binding
AURMO_RS00875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AURMO_RS00880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AURMO_RS00895	COG0659	secondary active sulfate transmembrane transporter activity
AURMO_RS00900	COG0051	transcription antitermination factor activity, RNA binding
AURMO_RS00905	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AURMO_RS00910	COG0088	Forms part of the polypeptide exit tunnel
AURMO_RS00915	COG0089	rRNA binding
AURMO_RS00920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AURMO_RS00925	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AURMO_RS00930	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AURMO_RS00935	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AURMO_RS00940	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AURMO_RS00945	COG0255	Belongs to the universal ribosomal protein uL29 family
AURMO_RS00950	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AURMO_RS00955	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AURMO_RS00960	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AURMO_RS00965	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AURMO_RS00970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AURMO_RS00975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AURMO_RS00980	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AURMO_RS00985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AURMO_RS00990	COG1841	ribosomal large subunit assembly
AURMO_RS00995	COG0200	Binds to the 23S rRNA
AURMO_RS01005	COG0563	adenylate kinase activity
AURMO_RS01010	COG0024	Methionine aminopeptidase
AURMO_RS01020	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AURMO_RS01025	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AURMO_RS01030	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AURMO_RS01035	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AURMO_RS01040	COG0202	RNA polymerase activity
AURMO_RS01045	COG0203	ribosomal protein L17
AURMO_RS01050	COG0101	tRNA pseudouridine synthase activity
AURMO_RS01055	COG3550	peptidyl-serine autophosphorylation
AURMO_RS01065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AURMO_RS01070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AURMO_RS01075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AURMO_RS01080	COG1072	(Pantothenic acid kinase))
AURMO_RS01085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AURMO_RS01090	COG0736	holo-[acyl-carrier-protein] synthase activity
AURMO_RS01095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AURMO_RS01100	COG0802	atpase or kinase
AURMO_RS01105	COG1214	PFAM Peptidase M22, glycoprotease
AURMO_RS01105	COG0456	acetyltransferase
AURMO_RS01110	COG1214	PFAM Peptidase M22, glycoprotease
AURMO_RS01110	COG0456	acetyltransferase
AURMO_RS01115	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AURMO_RS01125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AURMO_RS01140	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AURMO_RS01175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AURMO_RS01175	COG0519	Catalyzes the synthesis of GMP from XMP
AURMO_RS01195	COG0516	GMP reductase activity
AURMO_RS01250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AURMO_RS01380	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AURMO_RS01455	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AURMO_RS01460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AURMO_RS01475	COG0579	oxidoreductase
AURMO_RS01495	COG1435	thymidine kinase activity
AURMO_RS01500	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AURMO_RS01525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AURMO_RS01535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AURMO_RS01565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AURMO_RS01565	COG1754	DNA topoisomerase type I activity
AURMO_RS01570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AURMO_RS01575	COG0470	DNA polymerase III
AURMO_RS01615	COG3415	Transposase
AURMO_RS01615	COG2801	Transposase and inactivated derivatives
AURMO_RS01620	COG2409	Drug exporters of the RND superfamily
AURMO_RS01630	COG2801	Transposase and inactivated derivatives
AURMO_RS01640	COG1132	(ABC) transporter
AURMO_RS01650	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AURMO_RS01655	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AURMO_RS01655	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AURMO_RS01670	COG0180	Tryptophanyl-tRNA synthetase
AURMO_RS01675	COG0708	Exodeoxyribonuclease III
AURMO_RS01695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AURMO_RS01700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AURMO_RS01700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AURMO_RS01700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AURMO_RS01705	COG1105	Belongs to the carbohydrate kinase PfkB family
AURMO_RS01710	COG1349	DNA-binding transcription factor activity
AURMO_RS01715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AURMO_RS01720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AURMO_RS01725	COG1053	succinate dehydrogenase
AURMO_RS01735	COG2009	succinate dehydrogenase
AURMO_RS01740	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AURMO_RS01740	COG0662	Cupin 2, conserved barrel domain protein
AURMO_RS01745	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AURMO_RS01760	COG4770	biotin carboxylase activity
AURMO_RS01765	COG0424	maF-like protein
AURMO_RS01770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AURMO_RS01780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AURMO_RS01795	COG0463	Glycosyl transferase, family 2
AURMO_RS01815	COG1316	TRANSCRIPTIONal
AURMO_RS01830	COG1960	acyl-CoA dehydrogenase activity
AURMO_RS01835	COG1482	cell wall glycoprotein biosynthetic process
AURMO_RS01865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AURMO_RS01870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AURMO_RS01880	COG5000	phosphorelay sensor kinase activity
AURMO_RS01880	COG5002	protein histidine kinase activity
AURMO_RS01885	COG5401	PFAM Sporulation and spore germination
AURMO_RS01890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AURMO_RS01900	COG0653	protein targeting
AURMO_RS01970	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AURMO_RS01970	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AURMO_RS01980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AURMO_RS01985	COG1250	3-hydroxyacyl-CoA dehydrogenase
AURMO_RS01985	COG1024	Enoyl-CoA hydratase
AURMO_RS02010	COG3594	Acyltransferase
AURMO_RS02015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AURMO_RS02020	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AURMO_RS02050	COG1088	dTDP-glucose 4,6-dehydratase activity
AURMO_RS02060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AURMO_RS02065	COG1162	GTPase activity
AURMO_RS02070	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AURMO_RS02075	COG1595	DNA-templated transcription, initiation
AURMO_RS02085	COG2826	transposase and inactivated derivatives, IS30 family
AURMO_RS02090	COG0567	Dehydrogenase, E1 component
AURMO_RS02090	COG0508	dehydrogenase complex catalyzes the overall conversion of
AURMO_RS02115	COG1132	(ABC) transporter
AURMO_RS02195	COG0018	arginyl-trna synthetase
AURMO_RS02205	COG0460	homoserine dehydrogenase
AURMO_RS02215	COG0083	homoserine kinase activity
AURMO_RS02230	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AURMO_RS02235	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AURMO_RS02250	COG1045	serine acetyltransferase
AURMO_RS02265	COG2890	protein-(glutamine-N5) methyltransferase activity
AURMO_RS02275	COG0009	L-threonylcarbamoyladenylate synthase
AURMO_RS02280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AURMO_RS02290	COG3177	Filamentation induced by cAMP protein fic
AURMO_RS02295	COG0356	it plays a direct role in the translocation of protons across the membrane
AURMO_RS02300	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AURMO_RS02305	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AURMO_RS02310	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AURMO_RS02315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AURMO_RS02320	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AURMO_RS02325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AURMO_RS02330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AURMO_RS02385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AURMO_RS02390	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AURMO_RS02395	COG0750	zinc metalloprotease
AURMO_RS02400	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AURMO_RS02410	COG0442	prolyl-tRNA aminoacylation
AURMO_RS02425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AURMO_RS02430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AURMO_RS02460	COG2884	Cell division ATP-binding protein ftsE
AURMO_RS02465	COG2177	Part of the ABC transporter FtsEX involved in
AURMO_RS02470	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AURMO_RS02490	COG0386	Belongs to the glutathione peroxidase family
AURMO_RS02505	COG0483	inositol monophosphate 1-phosphatase activity
AURMO_RS02515	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AURMO_RS02530	COG1228	amidohydrolase
AURMO_RS02535	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AURMO_RS02560	COG0702	epimerase
AURMO_RS02585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AURMO_RS02595	COG2267	carboxylic ester hydrolase activity
AURMO_RS02600	COG0306	phosphate transporter
AURMO_RS02610	COG2252	PERMEase
AURMO_RS02625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AURMO_RS02685	COG3480	Lon protease (S16) C-terminal proteolytic domain
AURMO_RS02690	COG1615	UPF0182 protein
AURMO_RS02695	COG1271	oxidase subunit
AURMO_RS02700	COG1294	oxidase, subunit
AURMO_RS02705	COG4988	ABC transporter
AURMO_RS02710	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AURMO_RS02720	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AURMO_RS02725	COG1082	Xylose isomerase domain protein TIM barrel
AURMO_RS02730	COG0129	dihydroxy-acid dehydratase activity
AURMO_RS02740	COG0440	acetolactate synthase activity
AURMO_RS02745	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AURMO_RS02765	COG0473	3-isopropylmalate dehydrogenase activity
AURMO_RS02770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AURMO_RS02775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AURMO_RS02785	COG1597	lipid kinase activity
AURMO_RS02800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AURMO_RS02805	COG0066	3-isopropylmalate dehydratase activity
AURMO_RS02810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AURMO_RS02820	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AURMO_RS02825	COG1181	Belongs to the D-alanine--D-alanine ligase family
AURMO_RS02840	COG0742	ribosomal rna small subunit methyltransferase
AURMO_RS02845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AURMO_RS02850	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AURMO_RS02855	COG0552	protein localization to endoplasmic reticulum
AURMO_RS02865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AURMO_RS02875	COG0228	four-way junction DNA binding
AURMO_RS02880	COG1837	Belongs to the UPF0109 family
AURMO_RS02885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AURMO_RS02890	COG0336	Belongs to the RNA methyltransferase TrmD family
AURMO_RS02895	COG0335	large ribosomal subunit rRNA binding
AURMO_RS02905	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AURMO_RS02920	COG4974	Belongs to the 'phage' integrase family
AURMO_RS02950	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AURMO_RS02955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AURMO_RS02960	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AURMO_RS02985	COG0366	Alpha amylase catalytic
AURMO_RS02990	COG1674	ftsk spoiiie
AURMO_RS03000	COG1546	Belongs to the CinA family
AURMO_RS03000	COG1058	Belongs to the CinA family
AURMO_RS03005	COG1396	sequence-specific DNA binding
AURMO_RS03015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AURMO_RS03020	COG2137	regulation of response to DNA damage stimulus
AURMO_RS03030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AURMO_RS03035	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AURMO_RS03040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AURMO_RS03050	COG2813	Specifically methylates the guanine in position
AURMO_RS03060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AURMO_RS03085	COG0495	leucyl-tRNA aminoacylation
AURMO_RS03090	COG0515	serine threonine protein kinase
AURMO_RS03090	COG2815	serine threonine protein kinase
AURMO_RS03105	COG0142	geranyltranstransferase activity
AURMO_RS03115	COG2001	Belongs to the MraZ family
AURMO_RS03120	COG0275	rRNA processing
AURMO_RS03130	COG0768	penicillin binding
AURMO_RS03135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AURMO_RS03145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AURMO_RS03150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AURMO_RS03160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AURMO_RS03165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AURMO_RS03175	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AURMO_RS03180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AURMO_RS03185	COG1799	cell septum assembly
AURMO_RS03200	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AURMO_RS03210	COG1660	Displays ATPase and GTPase activities
AURMO_RS03215	COG1481	regulation of sporulation
AURMO_RS03230	COG0126	phosphoglycerate kinase activity
AURMO_RS03235	COG0149	triose-phosphate isomerase activity
AURMO_RS03240	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AURMO_RS03250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AURMO_RS03255	COG2801	Transposase and inactivated derivatives
AURMO_RS03255	COG3415	Transposase
AURMO_RS03260	COG0363	glucosamine-6-phosphate deaminase activity
AURMO_RS03275	COG0166	Belongs to the GPI family
AURMO_RS03280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AURMO_RS03290	COG0109	protoheme IX farnesyltransferase activity
AURMO_RS03295	COG1612	heme a metabolic process
AURMO_RS03300	COG0719	Fe-S assembly protein
AURMO_RS03315	COG0396	ATPase activity
AURMO_RS03320	COG2151	metal-sulfur cluster biosynthetic enzyme
AURMO_RS03335	COG0488	(ABC) transporter
AURMO_RS03340	COG2860	membrane
AURMO_RS03345	COG1381	Involved in DNA repair and RecF pathway recombination
AURMO_RS03350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AURMO_RS03375	COG0358	DNA primase activity
AURMO_RS03400	COG0242	peptide deformylase activity
AURMO_RS03405	COG0697	spore germination
AURMO_RS03410	COG0438	transferase activity, transferring glycosyl groups
AURMO_RS03465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AURMO_RS03475	COG0582	viral genome integration into host DNA
AURMO_RS03505	COG2801	Transposase and inactivated derivatives
AURMO_RS03515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AURMO_RS03520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AURMO_RS03535	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AURMO_RS03555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AURMO_RS03590	COG2801	Transposase and inactivated derivatives
AURMO_RS03590	COG3415	Transposase
AURMO_RS03595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AURMO_RS03600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AURMO_RS03600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AURMO_RS03610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AURMO_RS03615	COG0174	glutamine synthetase
AURMO_RS03630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AURMO_RS03635	COG0321	lipoyl(octanoyl) transferase activity
AURMO_RS03645	COG0508	dehydrogenase complex catalyzes the overall conversion of
AURMO_RS03650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AURMO_RS03655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AURMO_RS03675	COG2826	transposase and inactivated derivatives, IS30 family
AURMO_RS03690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AURMO_RS03715	COG0756	dUTP diphosphatase activity
AURMO_RS03730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AURMO_RS03735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AURMO_RS03740	COG1024	Enoyl-CoA hydratase
AURMO_RS03740	COG1250	3-hydroxyacyl-CoA dehydrogenase
AURMO_RS03745	COG0183	Belongs to the thiolase family
AURMO_RS03805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AURMO_RS03815	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AURMO_RS03820	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AURMO_RS03825	COG0217	transcriptional regulatory protein
AURMO_RS03830	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AURMO_RS03835	COG0632	four-way junction helicase activity
AURMO_RS03840	COG2255	four-way junction helicase activity
AURMO_RS03850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AURMO_RS03855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AURMO_RS03860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AURMO_RS03885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AURMO_RS03895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AURMO_RS03900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AURMO_RS03910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AURMO_RS03915	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AURMO_RS03920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AURMO_RS03925	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AURMO_RS03930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AURMO_RS03935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AURMO_RS03940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AURMO_RS03945	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AURMO_RS03950	COG0540	Belongs to the ATCase OTCase family
AURMO_RS03955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AURMO_RS03965	COG0505	Belongs to the CarA family
AURMO_RS03970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AURMO_RS03975	COG0284	orotidine-5'-phosphate decarboxylase activity
AURMO_RS03980	COG0194	GDP metabolic process
AURMO_RS03985	COG1758	RNA polymerase activity
AURMO_RS03995	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AURMO_RS04005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AURMO_RS04020	COG0140	phosphoribosyl-ATP diphosphatase activity
AURMO_RS04025	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AURMO_RS04030	COG0107	imidazoleglycerol-phosphate synthase activity
AURMO_RS04055	COG0134	indole-3-glycerol-phosphate synthase activity
AURMO_RS04060	COG0133	tryptophan synthase activity
AURMO_RS04065	COG0159	tryptophan synthase activity
AURMO_RS04070	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AURMO_RS04075	COG0067	glutamate synthase
AURMO_RS04075	COG0070	glutamate synthase
AURMO_RS04075	COG0069	glutamate synthase activity
AURMO_RS04085	COG0469	pyruvate kinase activity
AURMO_RS04100	COG2050	protein possibly involved in aromatic compounds catabolism
AURMO_RS04110	COG0539	negative regulation of cytoplasmic translation
AURMO_RS04115	COG0237	dephospho-CoA kinase activity
AURMO_RS04120	COG0556	nucleotide-excision repair
AURMO_RS04130	COG0322	excinuclease ABC activity
AURMO_RS04135	COG0584	glycerophosphoryl diester phosphodiesterase
AURMO_RS04140	COG1028	Short-chain dehydrogenase reductase Sdr
AURMO_RS04145	COG0494	nUDIX hydrolase
AURMO_RS04160	COG0697	spore germination
AURMO_RS04165	COG0738	Major facilitator superfamily
AURMO_RS04170	COG0738	Major facilitator superfamily
AURMO_RS04175	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AURMO_RS04180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AURMO_RS04185	COG1845	cytochrome c oxidase, subunit III
AURMO_RS04190	COG2010	Cytochrome c
AURMO_RS04195	COG0723	plastoquinol--plastocyanin reductase activity
AURMO_RS04200	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AURMO_RS04215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AURMO_RS04220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AURMO_RS04230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AURMO_RS04240	COG0167	dihydroorotate dehydrogenase activity
AURMO_RS04245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AURMO_RS04250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AURMO_RS04255	COG0587	DNA-directed DNA polymerase activity
AURMO_RS04270	COG0805	protein transport
AURMO_RS04275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AURMO_RS04290	COG0545	Peptidyl-prolyl cis-trans isomerase
AURMO_RS04300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AURMO_RS04310	COG1968	undecaprenyl-diphosphatase activity
AURMO_RS04355	COG0254	rRNA binding
AURMO_RS04360	COG1119	ATPase activity
AURMO_RS04365	COG0297	glycogen (starch) synthase activity
AURMO_RS04370	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AURMO_RS04375	COG3830	Belongs to the UPF0237 family
AURMO_RS04375	COG0560	Phosphoserine phosphatase
AURMO_RS04380	COG1028	Short-chain dehydrogenase reductase Sdr
AURMO_RS04395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AURMO_RS04400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AURMO_RS04410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AURMO_RS04420	COG0537	adenosine 5'-monophosphoramidase activity
AURMO_RS04430	COG0484	heat shock protein binding
AURMO_RS04435	COG1420	regulation of RNA biosynthetic process
AURMO_RS04450	COG0481	GTPase activity
AURMO_RS04455	COG0268	Binds directly to 16S ribosomal RNA
AURMO_RS04470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AURMO_RS04475	COG4129	membrane
AURMO_RS04480	COG1472	Belongs to the glycosyl hydrolase 3 family
AURMO_RS04490	COG0446	pyridine nucleotide-disulphide oxidoreductase
AURMO_RS04500	COG3842	ATPase activity
AURMO_RS04510	COG0604	alcohol dehydrogenase
AURMO_RS04515	COG2824	Alkylphosphonate utilization operon protein PhnA
AURMO_RS04520	COG0698	ribose 5-phosphate isomerase
AURMO_RS04530	COG0799	negative regulation of ribosome biogenesis
AURMO_RS04540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AURMO_RS04550	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AURMO_RS04555	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AURMO_RS04560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AURMO_RS04565	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AURMO_RS04570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AURMO_RS04575	COG1530	ribonuclease E activity
AURMO_RS04585	COG0477	Major facilitator Superfamily
AURMO_RS04590	COG0105	UTP biosynthetic process
AURMO_RS04600	COG0285	dihydrofolate synthase activity
AURMO_RS04605	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AURMO_RS04610	COG0525	valine-tRNA ligase activity
AURMO_RS04630	COG2801	Transposase and inactivated derivatives
AURMO_RS04635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AURMO_RS04655	COG0531	amino acid
AURMO_RS04660	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AURMO_RS04670	COG1940	carbohydrate kinase activity
AURMO_RS04690	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AURMO_RS04695	COG1192	Involved in chromosome partitioning
AURMO_RS04710	COG1716	ATPase activity
AURMO_RS04715	COG0513	Belongs to the DEAD box helicase family
AURMO_RS04725	COG3046	protein related to deoxyribodipyrimidine photolyase
AURMO_RS04730	COG0697	spore germination
AURMO_RS04745	COG0697	spore germination
AURMO_RS04750	COG1280	lysine exporter protein (LysE YggA)
AURMO_RS04755	COG4702	Belongs to the UPF0303 family
AURMO_RS04770	COG0477	Major facilitator Superfamily
AURMO_RS04775	COG0402	S-adenosylhomocysteine deaminase activity
AURMO_RS04805	COG1160	GTP binding
AURMO_RS04810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AURMO_RS04825	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AURMO_RS04840	COG4974	Belongs to the 'phage' integrase family
AURMO_RS04845	COG0494	nUDIX hydrolase
AURMO_RS04850	COG0504	CTP synthase activity
AURMO_RS04855	COG0497	DNA recombination
AURMO_RS04860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AURMO_RS04875	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AURMO_RS04880	COG2079	MmgE PrpD family protein
AURMO_RS04885	COG1802	Transcriptional regulator
AURMO_RS04900	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AURMO_RS04905	COG2801	Transposase and inactivated derivatives
AURMO_RS04945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AURMO_RS04950	COG0165	Argininosuccinate lyase
AURMO_RS04955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AURMO_RS04960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AURMO_RS04965	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AURMO_RS04970	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AURMO_RS04980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AURMO_RS04980	COG0072	phenylalanine-tRNA ligase activity
AURMO_RS04985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AURMO_RS04990	COG2337	Toxic component of a toxin-antitoxin (TA) module
AURMO_RS05000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AURMO_RS05005	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AURMO_RS05010	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AURMO_RS05015	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AURMO_RS05030	COG2409	Drug exporters of the RND superfamily
AURMO_RS05045	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AURMO_RS05050	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AURMO_RS05055	COG0131	Imidazoleglycerol-phosphate dehydratase
AURMO_RS05060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AURMO_RS05065	COG1388	LysM domain
AURMO_RS05075	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AURMO_RS05080	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AURMO_RS05085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AURMO_RS05095	COG0740	serine-type endopeptidase activity
AURMO_RS05100	COG0740	serine-type endopeptidase activity
AURMO_RS05120	COG2826	transposase and inactivated derivatives, IS30 family
AURMO_RS05150	COG0544	peptidyl-prolyl cis-trans isomerase activity
AURMO_RS05165	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AURMO_RS05170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AURMO_RS05205	COG0668	transmembrane transport
AURMO_RS05220	COG1946	Acyl-CoA thioesterase
AURMO_RS05230	COG0824	Thioesterase
AURMO_RS05245	COG0629	single-stranded DNA binding
AURMO_RS05250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AURMO_RS05275	COG1012	belongs to the aldehyde dehydrogenase family
AURMO_RS05285	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AURMO_RS05310	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AURMO_RS05315	COG1122	ATPase activity
AURMO_RS05320	COG4721	ABC-type cobalt transport system, permease component
AURMO_RS05330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AURMO_RS05335	COG0154	amidase activity
AURMO_RS05340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AURMO_RS05350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AURMO_RS05355	COG0482	sulfurtransferase activity
AURMO_RS05370	COG0366	Alpha amylase catalytic
AURMO_RS05375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AURMO_RS05395	COG0628	permease
AURMO_RS05420	COG0575	Belongs to the CDS family
AURMO_RS05425	COG0233	cytoplasmic translational termination
AURMO_RS05430	COG0528	UMP kinase activity
AURMO_RS05435	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AURMO_RS05440	COG0052	Belongs to the universal ribosomal protein uS2 family
AURMO_RS05445	COG2814	Major facilitator Superfamily
AURMO_RS05460	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AURMO_RS05470	COG0612	Peptidase, M16
AURMO_RS05475	COG0667	Aldo Keto reductase
AURMO_RS05480	COG1185	polyribonucleotide nucleotidyltransferase activity
AURMO_RS05485	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AURMO_RS05505	COG1872	DUF167
AURMO_RS05515	COG0545	Peptidyl-prolyl cis-trans isomerase
AURMO_RS05530	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AURMO_RS05535	COG1012	belongs to the aldehyde dehydrogenase family
AURMO_RS05540	COG1028	Short-chain dehydrogenase reductase Sdr
AURMO_RS05545	COG2186	Transcriptional regulator
AURMO_RS05550	COG0531	amino acid
AURMO_RS05560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AURMO_RS05565	COG1027	Aspartate ammonia-lyase
AURMO_RS05570	COG1012	belongs to the aldehyde dehydrogenase family
AURMO_RS05575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AURMO_RS05580	COG0196	riboflavin kinase activity
AURMO_RS05595	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AURMO_RS05630	COG0714	Associated with various cellular activities
AURMO_RS05645	COG0631	protein serine/threonine phosphatase activity
AURMO_RS05660	COG1414	Transcriptional regulator
AURMO_RS05680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AURMO_RS05685	COG0571	ribonuclease III activity
AURMO_RS05690	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AURMO_RS05715	COG0586	Pfam SNARE associated Golgi protein
AURMO_RS05720	COG0384	phenazine biosynthesis protein PhzF
AURMO_RS05730	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AURMO_RS05735	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AURMO_RS05740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AURMO_RS05750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AURMO_RS05765	COG1960	acyl-CoA dehydrogenase activity
AURMO_RS05790	COG0513	Belongs to the DEAD box helicase family
AURMO_RS05805	COG0613	PHP domain protein
AURMO_RS05810	COG0006	proline dipeptidase activity
AURMO_RS05820	COG0583	DNA-binding transcription factor activity
AURMO_RS05825	COG1012	belongs to the aldehyde dehydrogenase family
AURMO_RS05830	COG2239	Acts as a magnesium transporter
AURMO_RS05845	COG1012	belongs to the aldehyde dehydrogenase family
AURMO_RS05855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AURMO_RS05860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AURMO_RS05865	COG2818	Glycosylase
AURMO_RS05875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AURMO_RS05895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AURMO_RS05950	COG1217	gtp-binding protein TYPA
AURMO_RS05985	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AURMO_RS05985	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AURMO_RS05990	COG0509	glycine decarboxylation via glycine cleavage system
AURMO_RS05995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AURMO_RS06010	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AURMO_RS06015	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AURMO_RS06025	COG1104	cysteine desulfurase activity
AURMO_RS06060	COG2801	Transposase and inactivated derivatives
AURMO_RS06070	COG1028	Short-chain dehydrogenase reductase Sdr
AURMO_RS06080	COG0300	oxidoreductase activity
AURMO_RS06100	COG0012	GTP binding
AURMO_RS06120	COG1322	Protein conserved in bacteria
AURMO_RS06135	COG0191	fructose-bisphosphate aldolase activity
AURMO_RS06145	COG1063	alcohol dehydrogenase
AURMO_RS06150	COG0246	Mannitol dehydrogenase
AURMO_RS06155	COG0395	ABC-type sugar transport system, permease component
AURMO_RS06175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AURMO_RS06180	COG1570	exodeoxyribonuclease VII activity
AURMO_RS06185	COG1722	exodeoxyribonuclease VII activity
AURMO_RS06195	COG0288	reversible hydration of carbon dioxide
AURMO_RS06200	COG0114	fumarate hydratase activity
AURMO_RS06205	COG0667	Aldo Keto reductase
AURMO_RS06240	COG2159	amidohydrolase
AURMO_RS06250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AURMO_RS06255	COG1414	Transcriptional regulator
AURMO_RS06310	COG3959	Transketolase, thiamine diphosphate binding domain
AURMO_RS06320	COG1063	alcohol dehydrogenase
AURMO_RS06325	COG1129	ABC transporter
AURMO_RS06330	COG1172	Belongs to the binding-protein-dependent transport system permease family
AURMO_RS06340	COG1028	Short-chain dehydrogenase reductase Sdr
AURMO_RS06390	COG0633	Ferredoxin
AURMO_RS06395	COG1028	Short-chain dehydrogenase reductase Sdr
AURMO_RS06410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AURMO_RS06410	COG0574	Belongs to the PEP-utilizing enzyme family
AURMO_RS06420	COG1414	Transcriptional regulator
AURMO_RS06440	COG2301	Belongs to the HpcH HpaI aldolase family
AURMO_RS06445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AURMO_RS06455	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AURMO_RS06460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AURMO_RS06465	COG3177	Filamentation induced by cAMP protein fic
AURMO_RS06490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AURMO_RS06495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AURMO_RS06500	COG0501	Belongs to the peptidase M48B family
AURMO_RS06505	COG1704	LemA family
AURMO_RS06520	COG2161	toxin-antitoxin pair type II binding
AURMO_RS06525	COG2026	Addiction module toxin, RelE StbE family
AURMO_RS06555	COG0148	phosphopyruvate hydratase activity
AURMO_RS06560	COG0124	histidyl-tRNA synthetase
AURMO_RS06575	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AURMO_RS06585	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AURMO_RS06600	COG0193	aminoacyl-tRNA hydrolase activity
AURMO_RS06605	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AURMO_RS06615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AURMO_RS06635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AURMO_RS06640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AURMO_RS06680	COG0488	(ABC) transporter
AURMO_RS06685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AURMO_RS06690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AURMO_RS06695	COG0084	hydrolase, TatD family'
AURMO_RS06700	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AURMO_RS06725	COG1760	l-serine dehydratase
AURMO_RS06755	COG1937	Protein conserved in bacteria
AURMO_RS06760	COG2217	Heavy metal translocating P-type atpase
AURMO_RS06775	COG0477	Major facilitator Superfamily
AURMO_RS06780	COG1643	Atp-dependent helicase
AURMO_RS06790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AURMO_RS06800	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AURMO_RS06800	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AURMO_RS06810	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AURMO_RS06815	COG0259	pyridoxamine-phosphate oxidase activity
AURMO_RS06825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AURMO_RS06880	COG0581	inorganic phosphate transmembrane transporter activity
AURMO_RS06890	COG2815	serine threonine protein kinase
AURMO_RS06890	COG0515	serine threonine protein kinase
AURMO_RS06925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AURMO_RS06990	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AURMO_RS07000	COG1278	Cold shock
AURMO_RS07020	COG0745	RESPONSE REGULATOR receiver
AURMO_RS07025	COG2205	protein histidine kinase activity
AURMO_RS07035	COG0459	protein refolding
AURMO_RS07040	COG1470	cell adhesion involved in biofilm formation
AURMO_RS07045	COG1278	Cold shock
AURMO_RS07070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AURMO_RS07075	COG0215	cysteine-tRNA ligase activity
AURMO_RS07080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AURMO_RS07080	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AURMO_RS07095	COG0588	phosphoglycerate mutase activity
AURMO_RS07110	COG0745	RESPONSE REGULATOR receiver
AURMO_RS07115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AURMO_RS07120	COG0406	alpha-ribazole phosphatase activity
AURMO_RS07120	COG0494	nUDIX hydrolase
AURMO_RS07130	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AURMO_RS07145	COG2197	response regulator
AURMO_RS07170	COG1741	Belongs to the pirin family
AURMO_RS07180	COG2843	Capsule synthesis protein
AURMO_RS07195	COG3415	Transposase
AURMO_RS07195	COG2801	Transposase and inactivated derivatives
AURMO_RS07200	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AURMO_RS07205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AURMO_RS07215	COG3384	dioxygenase
AURMO_RS07245	COG2217	Heavy metal translocating P-type atpase
AURMO_RS07250	COG0081	regulation of translation
AURMO_RS07255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AURMO_RS07265	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AURMO_RS07275	COG0436	Aminotransferase
AURMO_RS07285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AURMO_RS07295	COG2030	dehydratase
AURMO_RS07305	COG0076	glutamate decarboxylase activity
AURMO_RS07310	COG2957	Belongs to the agmatine deiminase family
AURMO_RS07345	COG1136	(ABC) transporter
AURMO_RS07365	COG1064	alcohol dehydrogenase
AURMO_RS07385	COG3885	ferrous iron binding
AURMO_RS07385	COG2078	PFAM AMMECR1 domain protein
AURMO_RS07395	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AURMO_RS07400	COG1846	Transcriptional regulator
AURMO_RS07415	COG0519	Catalyzes the synthesis of GMP from XMP
AURMO_RS07420	COG0174	glutamine synthetase
AURMO_RS07430	COG1834	amidinotransferase
AURMO_RS07440	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AURMO_RS07470	COG0045	succinate-CoA ligase (ADP-forming) activity
AURMO_RS07485	COG0584	glycerophosphoryl diester phosphodiesterase
AURMO_RS07505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AURMO_RS07515	COG1012	belongs to the aldehyde dehydrogenase family
AURMO_RS07520	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AURMO_RS07530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AURMO_RS07545	COG1079	Belongs to the binding-protein-dependent transport system permease family
AURMO_RS07550	COG4603	Belongs to the binding-protein-dependent transport system permease family
AURMO_RS07560	COG2801	Transposase and inactivated derivatives
AURMO_RS07565	COG3845	ABC transporter
AURMO_RS07570	COG1744	ABC transporter substrate-binding protein PnrA-like
AURMO_RS07575	COG0137	argininosuccinate synthase activity
AURMO_RS07580	COG0673	inositol 2-dehydrogenase activity
AURMO_RS07585	COG1940	carbohydrate kinase activity
AURMO_RS07590	COG2115	Belongs to the xylose isomerase family
AURMO_RS07595	COG1070	Carbohydrate kinase
AURMO_RS07600	COG4213	ABC transporter substrate-binding protein
AURMO_RS07610	COG4214	carbohydrate transport
AURMO_RS07630	COG0222	ribosome binding
AURMO_RS07635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AURMO_RS07640	COG1105	Belongs to the carbohydrate kinase PfkB family
AURMO_RS07645	COG2205	protein histidine kinase activity
AURMO_RS07650	COG0745	RESPONSE REGULATOR receiver
AURMO_RS07665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AURMO_RS07680	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AURMO_RS07680	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AURMO_RS07685	COG0604	alcohol dehydrogenase
AURMO_RS07690	COG0076	glutamate decarboxylase activity
AURMO_RS07695	COG1132	(ABC) transporter
AURMO_RS07700	COG1132	(ABC) transporter
AURMO_RS07740	COG0366	Alpha amylase catalytic
AURMO_RS07745	COG0739	heme binding
AURMO_RS07750	COG0483	inositol monophosphate 1-phosphatase activity
AURMO_RS07765	COG1228	amidohydrolase
AURMO_RS07775	COG2838	Isocitrate dehydrogenase
AURMO_RS07800	COG1666	GTP binding
AURMO_RS07815	COG2272	Belongs to the type-B carboxylesterase lipase family
AURMO_RS07835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AURMO_RS07845	COG2826	transposase and inactivated derivatives, IS30 family
AURMO_RS07850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AURMO_RS07885	COG0640	Transcriptional regulator
AURMO_RS07895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AURMO_RS07905	COG0151	Belongs to the GarS family
AURMO_RS07910	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AURMO_RS07915	COG2364	Membrane
AURMO_RS07930	COG2132	Multicopper oxidase
AURMO_RS07945	COG0438	transferase activity, transferring glycosyl groups
AURMO_RS07980	COG0366	Alpha amylase catalytic
AURMO_RS07985	COG3483	tryptophan 2,3-dioxygenase activity
AURMO_RS08000	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AURMO_RS08005	COG0047	phosphoribosylformylglycinamidine synthase activity
AURMO_RS08015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AURMO_RS08030	COG1605	Chorismate mutase
AURMO_RS08030	COG0287	Prephenate dehydrogenase
AURMO_RS08035	COG0697	spore germination
AURMO_RS08040	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AURMO_RS08045	COG0500	methyltransferase
AURMO_RS08050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AURMO_RS08055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AURMO_RS08065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AURMO_RS08070	COG0531	amino acid
AURMO_RS08075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AURMO_RS08090	COG0730	response to heat
AURMO_RS08095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AURMO_RS08100	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AURMO_RS08115	COG0142	geranyltranstransferase activity
AURMO_RS08120	COG2226	methyltransferase
AURMO_RS08130	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AURMO_RS08160	COG4948	Mandelate Racemase Muconate Lactonizing
AURMO_RS08165	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AURMO_RS08170	COG1333	cytochrome c biogenesis protein
AURMO_RS08175	COG0785	Cytochrome C biogenesis protein
AURMO_RS08180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AURMO_RS08185	COG0406	alpha-ribazole phosphatase activity
AURMO_RS08190	COG0017	Asparaginyl-tRNA synthetase
AURMO_RS08220	COG0640	Transcriptional regulator
AURMO_RS08225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AURMO_RS08230	COG0569	domain protein
AURMO_RS08235	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AURMO_RS08245	COG0590	tRNA wobble adenosine to inosine editing
AURMO_RS08255	COG0415	Belongs to the DNA photolyase family
AURMO_RS08265	COG1305	Transglutaminase-like
AURMO_RS08290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AURMO_RS08305	COG0300	oxidoreductase activity
AURMO_RS08315	COG1305	Transglutaminase-like
AURMO_RS08335	COG0300	oxidoreductase activity
AURMO_RS08380	COG0542	response to heat
AURMO_RS08385	COG2813	Specifically methylates the guanine in position
AURMO_RS08405	COG0789	Transcriptional regulator
AURMO_RS08410	COG0484	heat shock protein binding
AURMO_RS08415	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AURMO_RS08420	COG0443	Heat shock 70 kDa protein
AURMO_RS08435	COG1396	sequence-specific DNA binding
AURMO_RS08440	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
AURMO_RS08470	COG0142	geranyltranstransferase activity
AURMO_RS08475	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AURMO_RS08490	COG0717	Belongs to the dCTP deaminase family
AURMO_RS08500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AURMO_RS08515	COG0776	regulation of translation
AURMO_RS08520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AURMO_RS08525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AURMO_RS08530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AURMO_RS08540	COG0735	belongs to the Fur family
AURMO_RS08545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AURMO_RS08550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AURMO_RS08555	COG1121	(ABC) transporter
AURMO_RS08560	COG3443	Belongs to the bacterial solute-binding protein 9 family
AURMO_RS08560	COG0803	Belongs to the bacterial solute-binding protein 9 family
AURMO_RS08565	COG1054	Belongs to the UPF0176 family
AURMO_RS08590	COG0423	glycine-tRNA ligase activity
AURMO_RS08595	COG3590	peptidase
AURMO_RS08610	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AURMO_RS08665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AURMO_RS08685	COG0745	RESPONSE REGULATOR receiver
AURMO_RS08690	COG5002	protein histidine kinase activity
AURMO_RS08695	COG1716	ATPase activity
AURMO_RS08715	COG0768	penicillin binding
AURMO_RS08720	COG0515	serine threonine protein kinase
AURMO_RS08725	COG0515	serine threonine protein kinase
AURMO_RS08725	COG2815	serine threonine protein kinase
AURMO_RS08735	COG3764	Sortase (surface protein transpeptidase)
AURMO_RS08745	COG0457	Tetratricopeptide repeat
AURMO_RS08745	COG0705	Rhomboid family
AURMO_RS08815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AURMO_RS08820	COG0187	DNA topoisomerase II activity
AURMO_RS08830	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AURMO_RS08835	COG0592	DNA-directed DNA polymerase activity