locus-tag	class	description
AURUGA1_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AURUGA1_RS00010	COG0592	DNA-directed DNA polymerase activity
AURUGA1_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AURUGA1_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AURUGA1_RS00025	COG0187	DNA topoisomerase II activity
AURUGA1_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AURUGA1_RS00070	COG0705	Rhomboid family
AURUGA1_RS00070	COG0457	Tetratricopeptide repeat
AURUGA1_RS00080	COG3764	Sortase (surface protein transpeptidase)
AURUGA1_RS00090	COG0515	serine threonine protein kinase
AURUGA1_RS00095	COG0515	serine threonine protein kinase
AURUGA1_RS00100	COG0768	penicillin binding
AURUGA1_RS00120	COG1716	ATPase activity
AURUGA1_RS00150	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AURUGA1_RS00165	COG3590	peptidase
AURUGA1_RS00170	COG0423	glycine-tRNA ligase activity
AURUGA1_RS00200	COG1054	Belongs to the UPF0176 family
AURUGA1_RS00205	COG3443	Belongs to the bacterial solute-binding protein 9 family
AURUGA1_RS00205	COG0803	Belongs to the bacterial solute-binding protein 9 family
AURUGA1_RS00210	COG1121	(ABC) transporter
AURUGA1_RS00215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AURUGA1_RS00225	COG0735	belongs to the Fur family
AURUGA1_RS00230	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AURUGA1_RS00235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AURUGA1_RS00240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AURUGA1_RS00245	COG0776	regulation of translation
AURUGA1_RS00260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AURUGA1_RS00265	COG3011	Protein conserved in bacteria
AURUGA1_RS00270	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AURUGA1_RS00295	COG0022	dehydrogenase e1 component
AURUGA1_RS00300	COG0508	dehydrogenase complex catalyzes the overall conversion of
AURUGA1_RS00305	COG1280	lysine exporter protein (LysE YggA)
AURUGA1_RS00315	COG1522	sequence-specific DNA binding
AURUGA1_RS00320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AURUGA1_RS00330	COG3104	oligopeptide transport
AURUGA1_RS00335	COG2267	carboxylic ester hydrolase activity
AURUGA1_RS00345	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AURUGA1_RS00355	COG0477	Major facilitator Superfamily
AURUGA1_RS00360	COG1733	regulation of RNA biosynthetic process
AURUGA1_RS00365	COG1876	peptidase activity
AURUGA1_RS00375	COG0077	Prephenate dehydratase
AURUGA1_RS00380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AURUGA1_RS00395	COG1316	TRANSCRIPTIONal
AURUGA1_RS00405	COG0513	Belongs to the DEAD box helicase family
AURUGA1_RS00425	COG1914	H( )-stimulated, divalent metal cation uptake system
AURUGA1_RS00440	COG2326	polyphosphate kinase activity
AURUGA1_RS00455	COG0646	methionine synthase
AURUGA1_RS00455	COG1410	methionine synthase
AURUGA1_RS00470	COG4172	Belongs to the ABC transporter superfamily
AURUGA1_RS00490	COG0038	chloride channel
AURUGA1_RS00500	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AURUGA1_RS00505	COG0113	porphobilinogen synthase activity
AURUGA1_RS00515	COG0181	hydroxymethylbilane synthase activity
AURUGA1_RS00520	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AURUGA1_RS00525	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AURUGA1_RS00535	COG3253	May function as heme-dependent peroxidase
AURUGA1_RS00540	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AURUGA1_RS00560	COG0741	lytic transglycosylase activity
AURUGA1_RS00560	COG1196	nuclear chromosome segregation
AURUGA1_RS00560	COG0739	heme binding
AURUGA1_RS00565	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AURUGA1_RS00570	COG0037	tRNA processing
AURUGA1_RS00580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AURUGA1_RS00585	COG0302	gtp cyclohydrolase
AURUGA1_RS00595	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AURUGA1_RS00600	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AURUGA1_RS00615	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AURUGA1_RS00620	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AURUGA1_RS00630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AURUGA1_RS00635	COG0667	Aldo Keto reductase
AURUGA1_RS00660	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AURUGA1_RS00685	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AURUGA1_RS00700	COG4566	intracellular signal transduction
AURUGA1_RS00770	COG0085	RNA polymerase activity
AURUGA1_RS00775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AURUGA1_RS00785	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AURUGA1_RS00790	COG0049	tRNA binding
AURUGA1_RS00795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AURUGA1_RS00800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AURUGA1_RS00810	COG0659	secondary active sulfate transmembrane transporter activity
AURUGA1_RS00815	COG0051	transcription antitermination factor activity, RNA binding
AURUGA1_RS00820	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AURUGA1_RS00825	COG0088	Forms part of the polypeptide exit tunnel
AURUGA1_RS00830	COG0089	rRNA binding
AURUGA1_RS00835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AURUGA1_RS00840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AURUGA1_RS00845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AURUGA1_RS00850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AURUGA1_RS00855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AURUGA1_RS00860	COG0255	Belongs to the universal ribosomal protein uL29 family
AURUGA1_RS00865	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AURUGA1_RS00870	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AURUGA1_RS00875	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AURUGA1_RS00880	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AURUGA1_RS00885	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AURUGA1_RS00890	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AURUGA1_RS00895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AURUGA1_RS00900	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AURUGA1_RS00905	COG1841	ribosomal large subunit assembly
AURUGA1_RS00910	COG0200	Binds to the 23S rRNA
AURUGA1_RS00920	COG0563	adenylate kinase activity
AURUGA1_RS00925	COG0024	Methionine aminopeptidase
AURUGA1_RS00935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AURUGA1_RS00940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AURUGA1_RS00945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AURUGA1_RS00950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AURUGA1_RS00955	COG0202	RNA polymerase activity
AURUGA1_RS00960	COG0203	ribosomal protein L17
AURUGA1_RS00965	COG0101	tRNA pseudouridine synthase activity
AURUGA1_RS00970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AURUGA1_RS00975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AURUGA1_RS00980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AURUGA1_RS00985	COG1072	(Pantothenic acid kinase))
AURUGA1_RS00990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AURUGA1_RS00995	COG0736	holo-[acyl-carrier-protein] synthase activity
AURUGA1_RS01000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AURUGA1_RS01005	COG0802	atpase or kinase
AURUGA1_RS01015	COG0456	acetyltransferase
AURUGA1_RS01015	COG1214	PFAM Peptidase M22, glycoprotease
AURUGA1_RS01020	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AURUGA1_RS01045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AURUGA1_RS01080	COG0519	Catalyzes the synthesis of GMP from XMP
AURUGA1_RS01080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AURUGA1_RS01095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AURUGA1_RS01100	COG0516	GMP reductase activity
AURUGA1_RS01135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AURUGA1_RS01255	COG1132	(ABC) transporter
AURUGA1_RS01260	COG1132	(ABC) transporter
AURUGA1_RS01265	COG1982	Orn Lys Arg decarboxylase major
AURUGA1_RS01270	COG0076	glutamate decarboxylase activity
AURUGA1_RS01280	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AURUGA1_RS01280	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AURUGA1_RS01285	COG2217	Heavy metal translocating P-type atpase
AURUGA1_RS01305	COG3384	dioxygenase
AURUGA1_RS01320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AURUGA1_RS01325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AURUGA1_RS01345	COG1741	Belongs to the pirin family
AURUGA1_RS01360	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AURUGA1_RS01370	COG0406	alpha-ribazole phosphatase activity
AURUGA1_RS01370	COG0494	nUDIX hydrolase
AURUGA1_RS01375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AURUGA1_RS01380	COG0745	RESPONSE REGULATOR receiver
AURUGA1_RS01395	COG0588	phosphoglycerate mutase activity
AURUGA1_RS01410	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AURUGA1_RS01410	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AURUGA1_RS01415	COG0215	cysteine-tRNA ligase activity
AURUGA1_RS01420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AURUGA1_RS01445	COG1278	Cold shock
AURUGA1_RS01450	COG1470	cell adhesion involved in biofilm formation
AURUGA1_RS01455	COG0459	protein refolding
AURUGA1_RS01465	COG2205	protein histidine kinase activity
AURUGA1_RS01470	COG0745	RESPONSE REGULATOR receiver
AURUGA1_RS01490	COG1278	Cold shock
AURUGA1_RS01500	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AURUGA1_RS01540	COG1982	Orn Lys Arg decarboxylase major
AURUGA1_RS01550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AURUGA1_RS01590	COG0259	pyridoxamine-phosphate oxidase activity
AURUGA1_RS01595	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AURUGA1_RS01605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AURUGA1_RS01605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AURUGA1_RS01615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AURUGA1_RS01625	COG1643	Atp-dependent helicase
AURUGA1_RS01635	COG2040	homocysteine
AURUGA1_RS01640	COG1760	l-serine dehydratase
AURUGA1_RS01665	COG3842	ATPase activity
AURUGA1_RS01670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AURUGA1_RS01675	COG0084	hydrolase, TatD family'
AURUGA1_RS01680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AURUGA1_RS01685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AURUGA1_RS01690	COG0488	(ABC) transporter
AURUGA1_RS01695	COG1846	Transcriptional regulator
AURUGA1_RS01705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AURUGA1_RS01710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AURUGA1_RS01730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AURUGA1_RS01740	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AURUGA1_RS01745	COG0193	aminoacyl-tRNA hydrolase activity
AURUGA1_RS01760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AURUGA1_RS01770	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AURUGA1_RS01785	COG0124	histidyl-tRNA synthetase
AURUGA1_RS01790	COG0148	phosphopyruvate hydratase activity
AURUGA1_RS01805	COG1404	Belongs to the peptidase S8 family
AURUGA1_RS01810	COG1252	NADH dehydrogenase
AURUGA1_RS01820	COG4974	Belongs to the 'phage' integrase family
AURUGA1_RS01885	COG1704	LemA family
AURUGA1_RS01890	COG0501	Belongs to the peptidase M48B family
AURUGA1_RS01895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AURUGA1_RS01900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AURUGA1_RS01925	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AURUGA1_RS01930	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AURUGA1_RS01940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AURUGA1_RS01945	COG2301	Belongs to the HpcH HpaI aldolase family
AURUGA1_RS01960	COG1414	Transcriptional regulator
AURUGA1_RS01970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AURUGA1_RS01970	COG0574	Belongs to the PEP-utilizing enzyme family
AURUGA1_RS01985	COG1028	Short-chain dehydrogenase reductase Sdr
AURUGA1_RS01990	COG0633	Ferredoxin
AURUGA1_RS02025	COG1414	Transcriptional regulator
AURUGA1_RS02030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AURUGA1_RS02040	COG2159	amidohydrolase
AURUGA1_RS02070	COG0667	Aldo Keto reductase
AURUGA1_RS02075	COG0114	fumarate hydratase activity
AURUGA1_RS02080	COG0288	reversible hydration of carbon dioxide
AURUGA1_RS02090	COG1722	exodeoxyribonuclease VII activity
AURUGA1_RS02095	COG0604	alcohol dehydrogenase
AURUGA1_RS02100	COG1570	exodeoxyribonuclease VII activity
AURUGA1_RS02105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AURUGA1_RS02115	COG0191	fructose-bisphosphate aldolase activity
AURUGA1_RS02130	COG1322	Protein conserved in bacteria
AURUGA1_RS02135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AURUGA1_RS02150	COG3718	enzyme involved in inositol metabolism
AURUGA1_RS02155	COG3962	Belongs to the TPP enzyme family
AURUGA1_RS02170	COG1082	Xylose isomerase domain protein TIM barrel
AURUGA1_RS02180	COG1172	Belongs to the binding-protein-dependent transport system permease family
AURUGA1_RS02185	COG1129	ABC transporter
AURUGA1_RS02200	COG2188	Transcriptional regulator
AURUGA1_RS02205	COG0673	inositol 2-dehydrogenase activity
AURUGA1_RS02215	COG1607	acyl-coa hydrolase
AURUGA1_RS02220	COG0012	GTP binding
AURUGA1_RS02245	COG4221	oxidoreductase activity
AURUGA1_RS02255	COG4221	oxidoreductase activity
AURUGA1_RS02285	COG1104	cysteine desulfurase activity
AURUGA1_RS02295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AURUGA1_RS02300	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AURUGA1_RS02310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AURUGA1_RS02315	COG0509	glycine decarboxylation via glycine cleavage system
AURUGA1_RS02320	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AURUGA1_RS02320	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AURUGA1_RS02350	COG4166	transmembrane transport
AURUGA1_RS02355	COG0601	transmembrane transport
AURUGA1_RS02370	COG1217	gtp-binding protein TYPA
AURUGA1_RS02375	COG0672	)-iron permease
AURUGA1_RS02405	COG2171	N-acyltransferase activity
AURUGA1_RS02410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AURUGA1_RS02430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AURUGA1_RS02435	COG2818	Glycosylase
AURUGA1_RS02440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AURUGA1_RS02450	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AURUGA1_RS02460	COG1012	belongs to the aldehyde dehydrogenase family
AURUGA1_RS02475	COG2239	Acts as a magnesium transporter
AURUGA1_RS02480	COG1012	belongs to the aldehyde dehydrogenase family
AURUGA1_RS02485	COG0583	DNA-binding transcription factor activity
AURUGA1_RS02495	COG0006	proline dipeptidase activity
AURUGA1_RS02500	COG0613	PHP domain protein
AURUGA1_RS02510	COG0697	spore germination
AURUGA1_RS02520	COG0513	Belongs to the DEAD box helicase family
AURUGA1_RS02540	COG1960	acyl-CoA dehydrogenase activity
AURUGA1_RS02555	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AURUGA1_RS02565	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AURUGA1_RS02570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AURUGA1_RS02575	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AURUGA1_RS02590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AURUGA1_RS02595	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AURUGA1_RS02600	COG0750	zinc metalloprotease
AURUGA1_RS02605	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AURUGA1_RS02615	COG0442	prolyl-tRNA aminoacylation
AURUGA1_RS02630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AURUGA1_RS02635	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AURUGA1_RS02655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AURUGA1_RS02670	COG0196	riboflavin kinase activity
AURUGA1_RS02675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AURUGA1_RS02680	COG1012	belongs to the aldehyde dehydrogenase family
AURUGA1_RS02690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AURUGA1_RS02705	COG0531	amino acid
AURUGA1_RS02710	COG2188	Transcriptional regulator
AURUGA1_RS02715	COG1028	Short-chain dehydrogenase reductase Sdr
AURUGA1_RS02720	COG1012	belongs to the aldehyde dehydrogenase family
AURUGA1_RS02725	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AURUGA1_RS02735	COG0833	amino acid
AURUGA1_RS02740	COG0545	Peptidyl-prolyl cis-trans isomerase
AURUGA1_RS02750	COG1872	DUF167
AURUGA1_RS02765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AURUGA1_RS02770	COG1185	polyribonucleotide nucleotidyltransferase activity
AURUGA1_RS02775	COG0667	Aldo Keto reductase
AURUGA1_RS02780	COG0612	Peptidase, M16
AURUGA1_RS02790	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AURUGA1_RS02805	COG0477	Major facilitator Superfamily
AURUGA1_RS02810	COG0052	Belongs to the universal ribosomal protein uS2 family
AURUGA1_RS02815	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AURUGA1_RS02820	COG0528	UMP kinase activity
AURUGA1_RS02825	COG0233	cytoplasmic translational termination
AURUGA1_RS02875	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AURUGA1_RS02880	COG0366	Alpha amylase catalytic
AURUGA1_RS02895	COG0482	sulfurtransferase activity
AURUGA1_RS02900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AURUGA1_RS02910	COG1309	transcriptional regulator
AURUGA1_RS02915	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AURUGA1_RS02920	COG0154	amidase activity
AURUGA1_RS02925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AURUGA1_RS02935	COG4721	ABC-type cobalt transport system, permease component
AURUGA1_RS02940	COG1122	ATPase activity
AURUGA1_RS02970	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AURUGA1_RS02975	COG1012	belongs to the aldehyde dehydrogenase family
AURUGA1_RS02990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AURUGA1_RS03020	COG1946	Acyl-CoA thioesterase
AURUGA1_RS03035	COG0668	transmembrane transport
AURUGA1_RS03045	COG0698	ribose 5-phosphate isomerase
AURUGA1_RS03060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AURUGA1_RS03065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AURUGA1_RS03080	COG0544	peptidyl-prolyl cis-trans isomerase activity
AURUGA1_RS03095	COG0740	serine-type endopeptidase activity
AURUGA1_RS03100	COG0740	serine-type endopeptidase activity
AURUGA1_RS03105	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AURUGA1_RS03110	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AURUGA1_RS03115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AURUGA1_RS03125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AURUGA1_RS03130	COG0131	Imidazoleglycerol-phosphate dehydratase
AURUGA1_RS03135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AURUGA1_RS03140	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AURUGA1_RS03155	COG2409	Drug exporters of the RND superfamily
AURUGA1_RS03170	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AURUGA1_RS03175	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AURUGA1_RS03180	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AURUGA1_RS03185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AURUGA1_RS03190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AURUGA1_RS03195	COG0072	phenylalanine-tRNA ligase activity
AURUGA1_RS03195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AURUGA1_RS03205	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AURUGA1_RS03210	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AURUGA1_RS03215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AURUGA1_RS03220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AURUGA1_RS03230	COG0165	Argininosuccinate lyase
AURUGA1_RS03235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AURUGA1_RS03240	COG0367	asparagine synthase
AURUGA1_RS03280	COG0647	UMP catabolic process
AURUGA1_RS03285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AURUGA1_RS03300	COG1802	Transcriptional regulator
AURUGA1_RS03305	COG2079	MmgE PrpD family protein
AURUGA1_RS03310	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AURUGA1_RS03325	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AURUGA1_RS03330	COG0497	DNA recombination
AURUGA1_RS03335	COG0504	CTP synthase activity
AURUGA1_RS03340	COG0494	nUDIX hydrolase
AURUGA1_RS03360	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AURUGA1_RS03375	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AURUGA1_RS03380	COG1160	GTP binding
AURUGA1_RS03405	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AURUGA1_RS03430	COG0402	S-adenosylhomocysteine deaminase activity
AURUGA1_RS03445	COG4702	Belongs to the UPF0303 family
AURUGA1_RS03450	COG1280	lysine exporter protein (LysE YggA)
AURUGA1_RS03470	COG0697	spore germination
AURUGA1_RS03475	COG3046	protein related to deoxyribodipyrimidine photolyase
AURUGA1_RS03480	COG0513	Belongs to the DEAD box helicase family
AURUGA1_RS03485	COG1716	ATPase activity
AURUGA1_RS03500	COG1192	Involved in chromosome partitioning
AURUGA1_RS03505	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AURUGA1_RS03530	COG1940	carbohydrate kinase activity
AURUGA1_RS03540	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AURUGA1_RS03545	COG0531	amino acid
AURUGA1_RS03565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AURUGA1_RS03580	COG0525	valine-tRNA ligase activity
AURUGA1_RS03585	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AURUGA1_RS03590	COG0285	dihydrofolate synthase activity
AURUGA1_RS03600	COG0105	UTP biosynthetic process
AURUGA1_RS03605	COG2814	Major facilitator Superfamily
AURUGA1_RS03625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AURUGA1_RS03640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AURUGA1_RS03650	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AURUGA1_RS03660	COG0799	negative regulation of ribosome biogenesis
AURUGA1_RS03670	COG2824	Alkylphosphonate utilization operon protein PhnA
AURUGA1_RS03680	COG3842	ATPase activity
AURUGA1_RS03700	COG1472	Belongs to the glycosyl hydrolase 3 family
AURUGA1_RS03705	COG4129	membrane
AURUGA1_RS03710	COG1596	polysaccharide export
AURUGA1_RS03710	COG1555	photosystem II stabilization
AURUGA1_RS03725	COG0268	Binds directly to 16S ribosomal RNA
AURUGA1_RS03730	COG0481	GTPase activity
AURUGA1_RS03745	COG1420	regulation of RNA biosynthetic process
AURUGA1_RS03750	COG0484	heat shock protein binding
AURUGA1_RS03755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AURUGA1_RS03760	COG0537	adenosine 5'-monophosphoramidase activity
AURUGA1_RS03770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AURUGA1_RS03780	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AURUGA1_RS03785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AURUGA1_RS03805	COG0560	Phosphoserine phosphatase
AURUGA1_RS03810	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AURUGA1_RS03815	COG0297	glycogen (starch) synthase activity
AURUGA1_RS03820	COG1119	ATPase activity
AURUGA1_RS03825	COG0254	rRNA binding
AURUGA1_RS03870	COG1968	undecaprenyl-diphosphatase activity
AURUGA1_RS03880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AURUGA1_RS03890	COG0545	Peptidyl-prolyl cis-trans isomerase
AURUGA1_RS03895	COG2378	regulation of single-species biofilm formation
AURUGA1_RS03905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AURUGA1_RS03910	COG0805	protein transport
AURUGA1_RS03925	COG0587	DNA-directed DNA polymerase activity
AURUGA1_RS03930	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AURUGA1_RS03935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AURUGA1_RS03940	COG0167	dihydroorotate dehydrogenase activity
AURUGA1_RS03960	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AURUGA1_RS03965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AURUGA1_RS03975	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AURUGA1_RS03980	COG0723	plastoquinol--plastocyanin reductase activity
AURUGA1_RS03985	COG2010	Cytochrome c
AURUGA1_RS03990	COG1845	cytochrome c oxidase, subunit III
AURUGA1_RS03995	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AURUGA1_RS04000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AURUGA1_RS04005	COG0738	Major facilitator superfamily
AURUGA1_RS04010	COG0738	Major facilitator superfamily
AURUGA1_RS04020	COG0494	nUDIX hydrolase
AURUGA1_RS04025	COG1028	Short-chain dehydrogenase reductase Sdr
AURUGA1_RS04030	COG0584	glycerophosphoryl diester phosphodiesterase
AURUGA1_RS04035	COG0322	excinuclease ABC activity
AURUGA1_RS04045	COG0556	nucleotide-excision repair
AURUGA1_RS04050	COG0237	dephospho-CoA kinase activity
AURUGA1_RS04055	COG0539	negative regulation of cytoplasmic translation
AURUGA1_RS04065	COG2050	protein possibly involved in aromatic compounds catabolism
AURUGA1_RS04080	COG0469	pyruvate kinase activity
AURUGA1_RS04090	COG0070	glutamate synthase
AURUGA1_RS04090	COG0067	glutamate synthase
AURUGA1_RS04090	COG0069	glutamate synthase activity
AURUGA1_RS04095	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AURUGA1_RS04100	COG0159	tryptophan synthase activity
AURUGA1_RS04105	COG0133	tryptophan synthase activity
AURUGA1_RS04110	COG0134	indole-3-glycerol-phosphate synthase activity
AURUGA1_RS04135	COG0107	imidazoleglycerol-phosphate synthase activity
AURUGA1_RS04140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AURUGA1_RS04145	COG0140	phosphoribosyl-ATP diphosphatase activity
AURUGA1_RS04160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AURUGA1_RS04170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AURUGA1_RS04180	COG1758	RNA polymerase activity
AURUGA1_RS04185	COG0194	GDP metabolic process
AURUGA1_RS04190	COG0284	orotidine-5'-phosphate decarboxylase activity
AURUGA1_RS04195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AURUGA1_RS04200	COG0505	Belongs to the CarA family
AURUGA1_RS04210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AURUGA1_RS04215	COG0540	Belongs to the ATCase OTCase family
AURUGA1_RS04220	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AURUGA1_RS04225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AURUGA1_RS04230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AURUGA1_RS04235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AURUGA1_RS04240	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AURUGA1_RS04250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AURUGA1_RS04255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AURUGA1_RS04265	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AURUGA1_RS04270	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AURUGA1_RS04280	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AURUGA1_RS04305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AURUGA1_RS04310	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AURUGA1_RS04315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AURUGA1_RS04325	COG2255	four-way junction helicase activity
AURUGA1_RS04330	COG0632	four-way junction helicase activity
AURUGA1_RS04335	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AURUGA1_RS04340	COG0217	transcriptional regulatory protein
AURUGA1_RS04345	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AURUGA1_RS04350	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AURUGA1_RS04360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AURUGA1_RS04420	COG0183	Belongs to the thiolase family
AURUGA1_RS04425	COG1250	3-hydroxyacyl-CoA dehydrogenase
AURUGA1_RS04425	COG1024	Enoyl-CoA hydratase
AURUGA1_RS04430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AURUGA1_RS04435	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AURUGA1_RS04450	COG0756	dUTP diphosphatase activity
AURUGA1_RS04475	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AURUGA1_RS04480	COG0187	DNA topoisomerase II activity
AURUGA1_RS04495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AURUGA1_RS04505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AURUGA1_RS04510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AURUGA1_RS04515	COG0508	dehydrogenase complex catalyzes the overall conversion of
AURUGA1_RS04525	COG0321	lipoyl(octanoyl) transferase activity
AURUGA1_RS04530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AURUGA1_RS04545	COG0174	glutamine synthetase
AURUGA1_RS04550	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AURUGA1_RS04560	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AURUGA1_RS04560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AURUGA1_RS04565	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AURUGA1_RS04600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AURUGA1_RS04620	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AURUGA1_RS04635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AURUGA1_RS04640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AURUGA1_RS04670	COG2197	response regulator
AURUGA1_RS04680	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AURUGA1_RS04690	COG0438	transferase activity, transferring glycosyl groups
AURUGA1_RS04700	COG0242	peptide deformylase activity
AURUGA1_RS04725	COG0358	DNA primase activity
AURUGA1_RS04750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AURUGA1_RS04755	COG1381	Involved in DNA repair and RecF pathway recombination
AURUGA1_RS04760	COG2860	membrane
AURUGA1_RS04770	COG0488	(ABC) transporter
AURUGA1_RS04785	COG2151	metal-sulfur cluster biosynthetic enzyme
AURUGA1_RS04790	COG0396	ATPase activity
AURUGA1_RS04795	COG2146	nitrite reductase [NAD(P)H] activity
AURUGA1_RS04810	COG1612	heme a metabolic process
AURUGA1_RS04815	COG0109	protoheme IX farnesyltransferase activity
AURUGA1_RS04825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AURUGA1_RS04830	COG0166	Belongs to the GPI family
AURUGA1_RS04845	COG0363	glucosamine-6-phosphate deaminase activity
AURUGA1_RS04855	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AURUGA1_RS04860	COG0149	triose-phosphate isomerase activity
AURUGA1_RS04865	COG0126	phosphoglycerate kinase activity
AURUGA1_RS04870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AURUGA1_RS04880	COG1481	regulation of sporulation
AURUGA1_RS04885	COG1660	Displays ATPase and GTPase activities
AURUGA1_RS04895	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AURUGA1_RS04900	COG3599	regulation of cell shape
AURUGA1_RS04910	COG1799	cell septum assembly
AURUGA1_RS04915	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AURUGA1_RS04920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AURUGA1_RS04930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AURUGA1_RS04935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AURUGA1_RS04945	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AURUGA1_RS04950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AURUGA1_RS04960	COG0768	penicillin binding
AURUGA1_RS04970	COG0275	rRNA processing
AURUGA1_RS04975	COG2001	Belongs to the MraZ family
AURUGA1_RS04985	COG0142	geranyltranstransferase activity
AURUGA1_RS05000	COG2815	serine threonine protein kinase
AURUGA1_RS05000	COG0515	serine threonine protein kinase
AURUGA1_RS05005	COG0495	leucyl-tRNA aminoacylation
AURUGA1_RS05030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AURUGA1_RS05045	COG2813	Specifically methylates the guanine in position
AURUGA1_RS05055	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AURUGA1_RS05060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AURUGA1_RS05065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AURUGA1_RS05080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AURUGA1_RS05090	COG1396	sequence-specific DNA binding
AURUGA1_RS05095	COG1546	Belongs to the CinA family
AURUGA1_RS05095	COG1058	Belongs to the CinA family
AURUGA1_RS05105	COG1674	ftsk spoiiie
AURUGA1_RS05110	COG0366	Alpha amylase catalytic
AURUGA1_RS05135	COG1609	Transcriptional regulator
AURUGA1_RS05140	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AURUGA1_RS05145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AURUGA1_RS05150	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AURUGA1_RS05165	COG1090	epimerase
AURUGA1_RS05180	COG4974	Belongs to the 'phage' integrase family
AURUGA1_RS05195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AURUGA1_RS05205	COG0335	large ribosomal subunit rRNA binding
AURUGA1_RS05210	COG0336	Belongs to the RNA methyltransferase TrmD family
AURUGA1_RS05215	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AURUGA1_RS05220	COG1837	Belongs to the UPF0109 family
AURUGA1_RS05225	COG0228	four-way junction DNA binding
AURUGA1_RS05230	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AURUGA1_RS05240	COG1832	CoA-binding protein
AURUGA1_RS05245	COG2873	o-acetylhomoserine
AURUGA1_RS05255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AURUGA1_RS05260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AURUGA1_RS05270	COG1116	anion transmembrane transporter activity
AURUGA1_RS05280	COG0552	protein localization to endoplasmic reticulum
AURUGA1_RS05285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AURUGA1_RS05295	COG0742	ribosomal rna small subunit methyltransferase
AURUGA1_RS05310	COG1181	Belongs to the D-alanine--D-alanine ligase family
AURUGA1_RS05315	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AURUGA1_RS05325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AURUGA1_RS05330	COG0066	3-isopropylmalate dehydratase activity
AURUGA1_RS05335	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AURUGA1_RS05365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AURUGA1_RS05370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AURUGA1_RS05375	COG0473	3-isopropylmalate dehydrogenase activity
AURUGA1_RS05395	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AURUGA1_RS05400	COG0440	acetolactate synthase activity
AURUGA1_RS05410	COG0129	dihydroxy-acid dehydratase activity
AURUGA1_RS05415	COG1082	Xylose isomerase domain protein TIM barrel
AURUGA1_RS05420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AURUGA1_RS05425	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AURUGA1_RS05435	COG1615	UPF0182 protein
AURUGA1_RS05440	COG3480	Lon protease (S16) C-terminal proteolytic domain
AURUGA1_RS05470	COG0210	DNA helicase
AURUGA1_RS05500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AURUGA1_RS05520	COG2252	PERMEase
AURUGA1_RS05535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AURUGA1_RS05560	COG0702	epimerase
AURUGA1_RS05580	COG2986	histidine ammonia-lyase
AURUGA1_RS05585	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AURUGA1_RS05590	COG1228	amidohydrolase
AURUGA1_RS05595	COG0010	Belongs to the arginase family
AURUGA1_RS05605	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AURUGA1_RS05615	COG0483	inositol monophosphate 1-phosphatase activity
AURUGA1_RS05630	COG0386	Belongs to the glutathione peroxidase family
AURUGA1_RS05640	COG0463	Glycosyl transferase, family 2
AURUGA1_RS05660	COG1247	-acetyltransferase
AURUGA1_RS05670	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AURUGA1_RS05675	COG2177	Part of the ABC transporter FtsEX involved in
AURUGA1_RS05680	COG2884	Cell division ATP-binding protein ftsE
AURUGA1_RS05700	COG3485	protocatechuate 3,4-dioxygenase
AURUGA1_RS05715	COG0433	COG0433 Predicted ATPase
AURUGA1_RS05715	COG1674	ftsk spoiiie
AURUGA1_RS05735	COG0714	Associated with various cellular activities
AURUGA1_RS05750	COG0631	protein serine/threonine phosphatase activity
AURUGA1_RS05765	COG1414	Transcriptional regulator
AURUGA1_RS05775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AURUGA1_RS05780	COG0571	ribonuclease III activity
AURUGA1_RS05785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AURUGA1_RS05805	COG0586	Pfam SNARE associated Golgi protein
AURUGA1_RS05810	COG0384	phenazine biosynthesis protein PhzF
AURUGA1_RS05855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AURUGA1_RS05860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AURUGA1_RS05865	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AURUGA1_RS05870	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AURUGA1_RS05875	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AURUGA1_RS05880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AURUGA1_RS05885	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AURUGA1_RS05890	COG0356	it plays a direct role in the translocation of protons across the membrane
AURUGA1_RS05900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AURUGA1_RS05905	COG0009	L-threonylcarbamoyladenylate synthase
AURUGA1_RS05915	COG2890	protein-(glutamine-N5) methyltransferase activity
AURUGA1_RS05925	COG1045	serine acetyltransferase
AURUGA1_RS05940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AURUGA1_RS05945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AURUGA1_RS05960	COG0083	homoserine kinase activity
AURUGA1_RS05970	COG0460	homoserine dehydrogenase
AURUGA1_RS05980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AURUGA1_RS05985	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AURUGA1_RS06050	COG1216	Glycosyl transferase, family 2
AURUGA1_RS06095	COG0018	arginyl-trna synthetase
AURUGA1_RS06100	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AURUGA1_RS06105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AURUGA1_RS06115	COG0508	dehydrogenase complex catalyzes the overall conversion of
AURUGA1_RS06115	COG0567	Dehydrogenase, E1 component
AURUGA1_RS06125	COG1595	DNA-templated transcription, initiation
AURUGA1_RS06130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AURUGA1_RS06135	COG1162	GTPase activity
AURUGA1_RS06140	COG1088	dTDP-glucose 4,6-dehydratase activity
AURUGA1_RS06180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AURUGA1_RS06185	COG3594	Acyltransferase
AURUGA1_RS06200	COG1024	Enoyl-CoA hydratase
AURUGA1_RS06200	COG1250	3-hydroxyacyl-CoA dehydrogenase
AURUGA1_RS06205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AURUGA1_RS06280	COG0653	protein targeting
AURUGA1_RS06290	COG1040	competence protein
AURUGA1_RS06295	COG5401	PFAM Sporulation and spore germination
AURUGA1_RS06300	COG5002	protein histidine kinase activity
AURUGA1_RS06300	COG5000	phosphorelay sensor kinase activity
AURUGA1_RS06310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AURUGA1_RS06360	COG1316	TRANSCRIPTIONal
AURUGA1_RS06380	COG0463	Glycosyl transferase, family 2
AURUGA1_RS06395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AURUGA1_RS06410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AURUGA1_RS06415	COG0424	maF-like protein
AURUGA1_RS06420	COG4770	biotin carboxylase activity
AURUGA1_RS06435	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AURUGA1_RS06440	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AURUGA1_RS06440	COG0662	Cupin 2, conserved barrel domain protein
AURUGA1_RS06445	COG2009	succinate dehydrogenase
AURUGA1_RS06455	COG1053	succinate dehydrogenase
AURUGA1_RS06460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AURUGA1_RS06465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AURUGA1_RS06470	COG1349	DNA-binding transcription factor activity
AURUGA1_RS06480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AURUGA1_RS06480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AURUGA1_RS06480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AURUGA1_RS06485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AURUGA1_RS06485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AURUGA1_RS06510	COG0180	Tryptophanyl-tRNA synthetase
AURUGA1_RS06525	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AURUGA1_RS06525	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AURUGA1_RS06530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AURUGA1_RS06540	COG1132	(ABC) transporter
AURUGA1_RS06575	COG0501	Belongs to the peptidase M48B family
AURUGA1_RS06585	COG0470	DNA polymerase III
AURUGA1_RS06590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AURUGA1_RS06595	COG1754	DNA topoisomerase type I activity
AURUGA1_RS06595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AURUGA1_RS06625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AURUGA1_RS06635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AURUGA1_RS06645	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AURUGA1_RS06650	COG1435	thymidine kinase activity
AURUGA1_RS06670	COG0579	oxidoreductase
AURUGA1_RS06685	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AURUGA1_RS06735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AURUGA1_RS06745	COG1012	belongs to the aldehyde dehydrogenase family
AURUGA1_RS06750	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AURUGA1_RS06760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AURUGA1_RS06775	COG1079	Belongs to the binding-protein-dependent transport system permease family
AURUGA1_RS06780	COG4603	Belongs to the binding-protein-dependent transport system permease family
AURUGA1_RS06785	COG3845	ABC transporter
AURUGA1_RS06790	COG1744	ABC transporter substrate-binding protein PnrA-like
AURUGA1_RS06795	COG0137	argininosuccinate synthase activity
AURUGA1_RS06800	COG0673	inositol 2-dehydrogenase activity
AURUGA1_RS06805	COG1940	carbohydrate kinase activity
AURUGA1_RS06810	COG2115	Belongs to the xylose isomerase family
AURUGA1_RS06815	COG1070	Carbohydrate kinase
AURUGA1_RS06820	COG4213	ABC transporter substrate-binding protein
AURUGA1_RS06830	COG4214	carbohydrate transport
AURUGA1_RS06845	COG0222	ribosome binding
AURUGA1_RS06850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AURUGA1_RS06855	COG1105	Belongs to the carbohydrate kinase PfkB family
AURUGA1_RS06860	COG2205	protein histidine kinase activity
AURUGA1_RS06865	COG0745	RESPONSE REGULATOR receiver
AURUGA1_RS06880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AURUGA1_RS06885	COG0081	regulation of translation
AURUGA1_RS06890	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AURUGA1_RS06900	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AURUGA1_RS06910	COG0436	Aminotransferase
AURUGA1_RS06920	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AURUGA1_RS06930	COG2030	dehydratase
AURUGA1_RS06940	COG0076	glutamate decarboxylase activity
AURUGA1_RS06945	COG2957	Belongs to the agmatine deiminase family
AURUGA1_RS06950	COG1064	alcohol dehydrogenase
AURUGA1_RS06970	COG3885	ferrous iron binding
AURUGA1_RS06970	COG2078	PFAM AMMECR1 domain protein
AURUGA1_RS06980	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AURUGA1_RS06985	COG1846	Transcriptional regulator
AURUGA1_RS06995	COG0519	Catalyzes the synthesis of GMP from XMP
AURUGA1_RS07000	COG0174	glutamine synthetase
AURUGA1_RS07015	COG1012	belongs to the aldehyde dehydrogenase family
AURUGA1_RS07030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AURUGA1_RS07030	COG0519	Catalyzes the synthesis of GMP from XMP
AURUGA1_RS07045	COG1802	Transcriptional regulator
AURUGA1_RS07055	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AURUGA1_RS07085	COG1834	amidinotransferase
AURUGA1_RS07090	COG0138	bifunctional purine biosynthesis protein purh
AURUGA1_RS07115	COG0045	succinate-CoA ligase (ADP-forming) activity
AURUGA1_RS07130	COG0584	glycerophosphoryl diester phosphodiesterase
AURUGA1_RS07155	COG0387	Pfam Sodium calcium exchanger
AURUGA1_RS07170	COG0366	Alpha amylase catalytic
AURUGA1_RS07195	COG2838	Isocitrate dehydrogenase
AURUGA1_RS07200	COG2409	Drug exporters of the RND superfamily
AURUGA1_RS07220	COG1666	GTP binding
AURUGA1_RS07225	COG2272	Belongs to the type-B carboxylesterase lipase family
AURUGA1_RS07235	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AURUGA1_RS07240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AURUGA1_RS07245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AURUGA1_RS07275	COG0745	RESPONSE REGULATOR receiver
AURUGA1_RS07285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AURUGA1_RS07290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AURUGA1_RS07300	COG0151	Belongs to the GarS family
AURUGA1_RS07305	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AURUGA1_RS07310	COG2364	Membrane
AURUGA1_RS07335	COG0438	transferase activity, transferring glycosyl groups
AURUGA1_RS07370	COG0366	Alpha amylase catalytic
AURUGA1_RS07375	COG3483	tryptophan 2,3-dioxygenase activity
AURUGA1_RS07390	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AURUGA1_RS07395	COG0047	phosphoribosylformylglycinamidine synthase activity
AURUGA1_RS07405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AURUGA1_RS07410	COG0656	L-ascorbic acid biosynthetic process
AURUGA1_RS07425	COG1605	Chorismate mutase
AURUGA1_RS07425	COG0287	Prephenate dehydrogenase
AURUGA1_RS07430	COG0697	spore germination
AURUGA1_RS07445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AURUGA1_RS07460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AURUGA1_RS07465	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AURUGA1_RS07475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AURUGA1_RS07480	COG0531	amino acid
AURUGA1_RS07490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AURUGA1_RS07500	COG0730	response to heat
AURUGA1_RS07505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AURUGA1_RS07510	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AURUGA1_RS07525	COG0142	geranyltranstransferase activity
AURUGA1_RS07530	COG2226	methyltransferase
AURUGA1_RS07535	COG1169	isochorismate synthase
AURUGA1_RS07540	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AURUGA1_RS07565	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AURUGA1_RS07570	COG4948	Mandelate Racemase Muconate Lactonizing
AURUGA1_RS07575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AURUGA1_RS07580	COG1333	cytochrome c biogenesis protein
AURUGA1_RS07585	COG0785	Cytochrome C biogenesis protein
AURUGA1_RS07590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AURUGA1_RS07595	COG0406	alpha-ribazole phosphatase activity
AURUGA1_RS07600	COG0017	Asparaginyl-tRNA synthetase
AURUGA1_RS07605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AURUGA1_RS07635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AURUGA1_RS07640	COG0569	domain protein
AURUGA1_RS07645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AURUGA1_RS07655	COG0590	tRNA wobble adenosine to inosine editing
AURUGA1_RS07660	COG0745	RESPONSE REGULATOR receiver
AURUGA1_RS07665	COG0415	Belongs to the DNA photolyase family
AURUGA1_RS07675	COG1305	Transglutaminase-like
AURUGA1_RS07685	COG2308	Evidence 4 Homologs of previously reported genes of
AURUGA1_RS07715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AURUGA1_RS07730	COG1231	oxidoreductase activity
AURUGA1_RS07735	COG0009	L-threonylcarbamoyladenylate synthase
AURUGA1_RS07770	COG1028	Short-chain dehydrogenase reductase Sdr
AURUGA1_RS07800	COG0542	response to heat
AURUGA1_RS07810	COG2813	Specifically methylates the guanine in position
AURUGA1_RS07825	COG0789	Transcriptional regulator
AURUGA1_RS07830	COG0484	heat shock protein binding
AURUGA1_RS07835	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AURUGA1_RS07840	COG0443	Heat shock 70 kDa protein
AURUGA1_RS07850	COG1902	pentaerythritol trinitrate reductase activity
AURUGA1_RS07880	COG0142	geranyltranstransferase activity
AURUGA1_RS07885	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AURUGA1_RS07890	COG2197	response regulator
AURUGA1_RS07900	COG0717	Belongs to the dCTP deaminase family
AURUGA1_RS07915	COG0305	Participates in initiation and elongation during chromosome replication
AURUGA1_RS07920	COG0359	binds to the 23S rRNA
AURUGA1_RS07925	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AURUGA1_RS07935	COG0360	Binds together with S18 to 16S ribosomal RNA
AURUGA1_RS07940	COG0617	tRNA 3'-terminal CCA addition
AURUGA1_RS07955	COG0492	ferredoxin-NADP+ reductase activity
AURUGA1_RS07960	COG3118	belongs to the thioredoxin family
AURUGA1_RS07965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AURUGA1_RS07985	COG0357	Ribosomal RNA small subunit methyltransferase G
AURUGA1_RS07995	COG0706	membrane insertase activity
AURUGA1_RS08000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AURUGA1_RS08010	COG0230	Belongs to the bacterial ribosomal protein bL34 family