locus-tag	class	description
H1343_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H1343_RS00030	COG0735	belongs to the Fur family
H1343_RS00040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H1343_RS00050	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H1343_RS00055	COG0667	Aldo Keto reductase
H1343_RS00065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H1343_RS00075	COG1764	response to oxidative stress
H1343_RS00090	COG3214	Protein conserved in bacteria
H1343_RS00095	COG1185	polyribonucleotide nucleotidyltransferase activity
H1343_RS00100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H1343_RS00105	COG0657	acetylesterase activity
H1343_RS00125	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H1343_RS00135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H1343_RS00150	COG0779	Required for maturation of 30S ribosomal subunits
H1343_RS00165	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H1343_RS00170	COG1396	sequence-specific DNA binding
H1343_RS00180	COG1253	flavin adenine dinucleotide binding
H1343_RS00195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H1343_RS00210	COG0456	acetyltransferase
H1343_RS00210	COG1214	PFAM Peptidase M22, glycoprotease
H1343_RS00215	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H1343_RS00225	COG0180	Tryptophanyl-tRNA synthetase
H1343_RS00235	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H1343_RS00240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H1343_RS00265	COG0116	Belongs to the methyltransferase superfamily
H1343_RS00265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H1343_RS00275	COG0776	regulation of translation
H1343_RS00280	COG0616	signal peptide processing
H1343_RS00290	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H1343_RS00295	COG1137	ATPase activity
H1343_RS00300	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H1343_RS00305	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H1343_RS00310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1343_RS00320	COG0071	Belongs to the small heat shock protein (HSP20) family
H1343_RS00325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H1343_RS00345	COG0745	RESPONSE REGULATOR receiver
H1343_RS00350	COG0642	Histidine kinase
H1343_RS00355	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H1343_RS00360	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1343_RS00360	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H1343_RS00370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H1343_RS00375	COG2205	protein histidine kinase activity
H1343_RS00380	COG3178	'Phosphotransferase
H1343_RS00385	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H1343_RS00395	COG1074	ATP-dependent DNA helicase activity
H1343_RS00405	COG0285	dihydrofolate synthase activity
H1343_RS00415	COG0159	tryptophan synthase activity
H1343_RS00430	COG0133	tryptophan synthase activity
H1343_RS00465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H1343_RS00465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H1343_RS00470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H1343_RS00485	COG1393	Belongs to the ArsC family
H1343_RS00500	COG0531	amino acid
H1343_RS00510	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H1343_RS00515	COG0443	Heat shock 70 kDa protein
H1343_RS00525	COG0484	heat shock protein binding
H1343_RS00530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H1343_RS00535	COG3963	phosphatidate phosphatase activity
H1343_RS00545	COG1028	Short-chain dehydrogenase reductase Sdr
H1343_RS00550	COG1643	Atp-dependent helicase
H1343_RS00560	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H1343_RS00575	COG1376	ErfK ybiS ycfS ynhG family protein
H1343_RS00605	COG0737	Belongs to the 5'-nucleotidase family
H1343_RS00610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H1343_RS00620	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H1343_RS00625	COG3639	organic phosphonate transmembrane transporter activity
H1343_RS00670	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H1343_RS00685	COG2011	ABC-type metal ion transport system permease component
H1343_RS00690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1343_RS00705	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H1343_RS00715	COG0251	oxidation-reduction process
H1343_RS00735	COG0601	transmembrane transport
H1343_RS00750	COG1760	l-serine dehydratase
H1343_RS00750	COG1760	l-serine dehydratase
H1343_RS00780	COG0582	viral genome integration into host DNA
H1343_RS00820	COG0328	RNA-DNA hybrid ribonuclease activity
H1343_RS00845	COG1968	undecaprenyl-diphosphatase activity
H1343_RS00855	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H1343_RS00885	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H1343_RS00885	COG0392	lysyltransferase activity
H1343_RS00900	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H1343_RS00925	COG1177	transmembrane transport
H1343_RS00930	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1343_RS00935	COG3842	ATPase activity
H1343_RS00945	COG4770	biotin carboxylase activity
H1343_RS00950	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H1343_RS00950	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H1343_RS00955	COG0346	lactoylglutathione lyase activity
H1343_RS00960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1343_RS00965	COG0438	transferase activity, transferring glycosyl groups
H1343_RS00965	COG1216	Glycosyl transferase, family 2
H1343_RS00970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1343_RS00980	COG0737	Belongs to the 5'-nucleotidase family
H1343_RS00990	COG0438	transferase activity, transferring glycosyl groups
H1343_RS01005	COG4558	Periplasmic binding protein
H1343_RS01010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1343_RS01015	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H1343_RS01020	COG3720	iron ion transport
H1343_RS01030	COG2080	2 iron, 2 sulfur cluster binding
H1343_RS01035	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H1343_RS01040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1343_RS01045	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H1343_RS01050	COG0131	Imidazoleglycerol-phosphate dehydratase
H1343_RS01060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H1343_RS01065	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H1343_RS01070	COG0107	imidazoleglycerol-phosphate synthase activity
H1343_RS01075	COG0140	phosphoribosyl-ATP diphosphatase activity
H1343_RS01085	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H1343_RS01100	COG2197	response regulator
H1343_RS01105	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H1343_RS01110	COG2133	pyrroloquinoline quinone binding
H1343_RS01125	COG1794	racemase activity, acting on amino acids and derivatives
H1343_RS01130	COG1522	sequence-specific DNA binding
H1343_RS01135	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
H1343_RS01140	COG1733	regulation of RNA biosynthetic process
H1343_RS01170	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H1343_RS01180	COG0237	dephospho-CoA kinase activity
H1343_RS01190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H1343_RS01195	COG0424	maF-like protein
H1343_RS01200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H1343_RS01205	COG1981	membrane
H1343_RS01215	COG3265	gluconokinase activity
H1343_RS01220	COG2610	gluconate transmembrane transporter activity
H1343_RS01225	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H1343_RS01235	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H1343_RS01240	COG0445	tRNA wobble uridine modification
H1343_RS01245	COG0357	Ribosomal RNA small subunit methyltransferase G
H1343_RS01270	COG0495	leucyl-tRNA aminoacylation
H1343_RS01275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H1343_RS01300	COG1238	metal cluster binding
H1343_RS01305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H1343_RS01310	COG2076	Multidrug Resistance protein
H1343_RS01320	COG5508	conserved small protein
H1343_RS01325	COG0501	Belongs to the peptidase M48B family
H1343_RS01330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H1343_RS01330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H1343_RS01345	COG0138	bifunctional purine biosynthesis protein purh
H1343_RS01365	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H1343_RS01375	COG0288	reversible hydration of carbon dioxide
H1343_RS01380	COG2845	Protein of unknown function (DUF459)
H1343_RS01385	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H1343_RS01395	COG0039	L-malate dehydrogenase activity
H1343_RS01400	COG0045	succinate-CoA ligase (ADP-forming) activity
H1343_RS01405	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H1343_RS01415	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1343_RS01430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1343_RS01435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H1343_RS01450	COG1764	response to oxidative stress
H1343_RS01490	COG3547	Transposase (IS116 IS110 IS902 family)
H1343_RS01505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H1343_RS01510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H1343_RS01515	COG0539	negative regulation of cytoplasmic translation
H1343_RS01525	COG0071	Belongs to the small heat shock protein (HSP20) family
H1343_RS01550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1343_RS01555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1343_RS01570	COG1228	amidohydrolase
H1343_RS01575	COG2986	histidine ammonia-lyase
H1343_RS01585	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H1343_RS01590	COG2080	2 iron, 2 sulfur cluster binding
H1343_RS01595	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H1343_RS01600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1343_RS01610	COG0747	negative chemotaxis
H1343_RS01615	COG0601	transmembrane transport
H1343_RS01620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1343_RS01630	COG1124	(ABC) transporter
H1343_RS01645	COG2207	Transcriptional regulator
H1343_RS01655	COG0667	Aldo Keto reductase
H1343_RS01665	COG0460	homoserine dehydrogenase
H1343_RS01670	COG0505	Belongs to the CarA family
H1343_RS01675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H1343_RS01690	COG0477	Major facilitator Superfamily
H1343_RS01695	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H1343_RS01700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H1343_RS01705	COG1845	cytochrome c oxidase, subunit III
H1343_RS01710	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H1343_RS01725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H1343_RS01730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H1343_RS01735	COG2188	Transcriptional regulator
H1343_RS01740	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H1343_RS01750	COG1175	transmembrane transport
H1343_RS01755	COG0395	ABC-type sugar transport system, permease component
H1343_RS01760	COG0673	inositol 2-dehydrogenase activity
H1343_RS01775	COG4774	siderophore transport
H1343_RS01795	COG0587	DNA-directed DNA polymerase activity
H1343_RS01820	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H1343_RS01825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H1343_RS01840	COG1187	pseudouridine synthase activity
H1343_RS01850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H1343_RS01855	COG0318	PFAM AMP-dependent synthetase and ligase
H1343_RS01870	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H1343_RS01875	COG0583	DNA-binding transcription factor activity
H1343_RS01905	COG0473	3-isopropylmalate dehydrogenase activity
H1343_RS01920	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1343_RS01930	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H1343_RS01935	COG2885	chlorophyll binding
H1343_RS01940	COG0165	Argininosuccinate lyase
H1343_RS01955	COG3046	protein related to deoxyribodipyrimidine photolyase
H1343_RS01965	COG1175	transmembrane transport
H1343_RS01970	COG0395	ABC-type sugar transport system, permease component
H1343_RS01975	COG3842	ATPase activity
H1343_RS01985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H1343_RS01995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H1343_RS02005	COG2358	TRAP transporter, solute receptor (TAXI family
H1343_RS02025	COG0601	transmembrane transport
H1343_RS02030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1343_RS02035	COG4172	Belongs to the ABC transporter superfamily
H1343_RS02050	COG0596	Alpha beta hydrolase
H1343_RS02060	COG1674	ftsk spoiiie
H1343_RS02070	COG0004	ammonium transporteR
H1343_RS02075	COG0347	Belongs to the P(II) protein family
H1343_RS02080	COG1946	Acyl-CoA thioesterase
H1343_RS02085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1343_RS02095	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1343_RS02105	COG0175	sulfate reduction
H1343_RS02110	COG0175	sulfate reduction
H1343_RS02115	COG2895	sulfate adenylyltransferase (ATP) activity
H1343_RS02120	COG2835	tetraacyldisaccharide 4'-kinase activity
H1343_RS02125	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H1343_RS02130	COG3118	belongs to the thioredoxin family
H1343_RS02150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1343_RS02155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1343_RS02160	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H1343_RS02165	COG2080	2 iron, 2 sulfur cluster binding
H1343_RS02180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1343_RS02195	COG1253	flavin adenine dinucleotide binding
H1343_RS02205	COG0586	Pfam SNARE associated Golgi protein
H1343_RS02215	COG0670	Belongs to the BI1 family
H1343_RS02260	COG0745	RESPONSE REGULATOR receiver
H1343_RS02270	COG0243	molybdopterin cofactor binding
H1343_RS02280	COG1733	regulation of RNA biosynthetic process
H1343_RS02285	COG2264	protein methyltransferase activity
H1343_RS02310	COG1960	acyl-CoA dehydrogenase activity
H1343_RS02315	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1343_RS02315	COG1024	Enoyl-CoA hydratase
H1343_RS02320	COG0559	Belongs to the binding-protein-dependent transport system permease family
H1343_RS02350	COG1960	acyl-CoA dehydrogenase activity
H1343_RS02360	COG0183	Belongs to the thiolase family
H1343_RS02375	COG0318	PFAM AMP-dependent synthetase and ligase
H1343_RS02380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H1343_RS02385	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H1343_RS02390	COG0181	hydroxymethylbilane synthase activity
H1343_RS02440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H1343_RS02445	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H1343_RS02455	COG1217	gtp-binding protein TYPA
H1343_RS02460	COG2610	gluconate transmembrane transporter activity
H1343_RS02465	COG0339	signal peptide processing
H1343_RS02475	COG2814	Major facilitator Superfamily
H1343_RS02480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1343_RS02485	COG1620	l-lactate permease
H1343_RS02490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1343_RS02495	COG0137	argininosuccinate synthase activity
H1343_RS02550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H1343_RS02560	COG3339	Conserved Protein
H1343_RS02565	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H1343_RS02580	COG4181	ATPase activity
H1343_RS02590	COG0670	Belongs to the BI1 family
H1343_RS02600	COG4536	flavin adenine dinucleotide binding
H1343_RS02615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H1343_RS02620	COG4133	protoheme IX ABC transporter activity
H1343_RS02625	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H1343_RS02635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H1343_RS02645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H1343_RS02665	COG2917	probably involved in intracellular septation
H1343_RS02675	COG0552	protein localization to endoplasmic reticulum
H1343_RS02685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H1343_RS02690	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H1343_RS02695	COG1902	pentaerythritol trinitrate reductase activity
H1343_RS02705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H1343_RS02710	COG0228	four-way junction DNA binding
H1343_RS02715	COG5002	protein histidine kinase activity
H1343_RS02715	COG3447	MASE1 domain protein
H1343_RS02715	COG5001	Diguanylate cyclase
H1343_RS02720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H1343_RS02730	COG0336	Belongs to the RNA methyltransferase TrmD family
H1343_RS02735	COG0697	spore germination
H1343_RS02745	COG0335	large ribosomal subunit rRNA binding
H1343_RS02750	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H1343_RS02770	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H1343_RS02775	COG1053	succinate dehydrogenase
H1343_RS02795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H1343_RS02825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H1343_RS02835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H1343_RS02840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H1343_RS02850	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H1343_RS02855	COG0494	nUDIX hydrolase
H1343_RS02865	COG0793	Belongs to the peptidase S41A family
H1343_RS02875	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H1343_RS02880	COG0799	negative regulation of ribosome biogenesis
H1343_RS02885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H1343_RS02895	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H1343_RS02915	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H1343_RS02945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1343_RS02950	COG0402	S-adenosylhomocysteine deaminase activity
H1343_RS02975	COG1120	ATPase activity
H1343_RS02985	COG4774	siderophore transport
H1343_RS02990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H1343_RS03005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1343_RS03010	COG4221	oxidoreductase activity
H1343_RS03025	COG0010	Belongs to the arginase family
H1343_RS03030	COG1126	abc transporter atp-binding protein
H1343_RS03035	COG0765	amino acid transport
H1343_RS03040	COG0765	amino acid transport
H1343_RS03055	COG0583	DNA-binding transcription factor activity
H1343_RS03060	COG0659	secondary active sulfate transmembrane transporter activity
H1343_RS03090	COG1024	Enoyl-CoA hydratase
H1343_RS03100	COG3938	Belongs to the proline racemase family
H1343_RS03115	COG3842	ATPase activity
H1343_RS03135	COG2130	NADP-dependent
H1343_RS03140	COG1309	transcriptional regulator
H1343_RS03165	COG2124	cytochrome p450
H1343_RS03165	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H1343_RS03175	COG0800	Aldolase
H1343_RS03180	COG3734	2-keto-3-deoxy-galactonokinase
H1343_RS03185	COG0251	oxidation-reduction process
H1343_RS03190	COG0493	'glutamate synthase
H1343_RS03200	COG1309	transcriptional regulator
H1343_RS03210	COG1280	lysine exporter protein (LysE YggA)
H1343_RS03230	COG2010	Cytochrome c
H1343_RS03245	COG3246	L-lysine catabolic process to acetate
H1343_RS03250	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1343_RS03250	COG0824	Thioesterase
H1343_RS03260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H1343_RS03265	COG1733	regulation of RNA biosynthetic process
H1343_RS03270	COG0003	Pfam Anion-transporting ATPase
H1343_RS03280	COG1966	Carbon starvation protein
H1343_RS03285	COG0602	queuosine metabolic process
H1343_RS03290	COG0720	synthase
H1343_RS03340	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H1343_RS03365	COG1028	Short-chain dehydrogenase reductase Sdr
H1343_RS03380	COG2188	Transcriptional regulator
H1343_RS03385	COG0583	DNA-binding transcription factor activity
H1343_RS03390	COG0667	Aldo Keto reductase
H1343_RS03395	COG1187	pseudouridine synthase activity
H1343_RS03400	COG2391	methyltransferase activity
H1343_RS03420	COG0443	Heat shock 70 kDa protein
H1343_RS03435	COG0697	spore germination
H1343_RS03440	COG0483	inositol monophosphate 1-phosphatase activity
H1343_RS03445	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H1343_RS03445	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H1343_RS03460	COG2894	cell division
H1343_RS03465	COG0850	regulation of cytokinetic process
H1343_RS03480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H1343_RS03485	COG0154	amidase activity
H1343_RS03495	COG4565	transcriptional regulatory protein
H1343_RS03505	COG2205	protein histidine kinase activity
H1343_RS03515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1343_RS03520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1343_RS03525	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H1343_RS03530	COG0352	thiamine-phosphate diphosphorylase activity
H1343_RS03535	COG0351	phosphomethylpyrimidine kinase
H1343_RS03545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H1343_RS03550	COG1321	iron dependent repressor
H1343_RS03555	COG0803	Belongs to the bacterial solute-binding protein 9 family
H1343_RS03560	COG1121	(ABC) transporter
H1343_RS03565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H1343_RS03565	COG1321	iron dependent repressor
H1343_RS03570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H1343_RS03580	COG0405	Gamma-glutamyltransferase
H1343_RS03585	COG1609	Transcriptional regulator
H1343_RS03590	COG0765	amino acid transport
H1343_RS03595	COG0765	amino acid transport
H1343_RS03600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1343_RS03605	COG1126	abc transporter atp-binding protein
H1343_RS03615	COG0730	response to heat
H1343_RS03630	COG0411	ABC transporter
H1343_RS03650	COG0784	Response regulator, receiver
H1343_RS03650	COG2198	Histidine kinase
H1343_RS03650	COG5002	protein histidine kinase activity
H1343_RS03665	COG2030	dehydratase
H1343_RS03675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1343_RS03685	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1343_RS03690	COG3842	ATPase activity
H1343_RS03705	COG0436	Aminotransferase
H1343_RS03720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1343_RS03730	COG0251	oxidation-reduction process
H1343_RS03745	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1343_RS03750	COG1840	ABC-type Fe3 transport system, periplasmic component
H1343_RS03755	COG3842	ATPase activity
H1343_RS03765	COG1012	belongs to the aldehyde dehydrogenase family
H1343_RS03775	COG2080	2 iron, 2 sulfur cluster binding
H1343_RS03780	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H1343_RS03785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1343_RS03790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H1343_RS03825	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H1343_RS03825	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H1343_RS03835	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H1343_RS03840	COG3473	Maleate cis-trans isomerase
H1343_RS03845	COG0596	Alpha beta hydrolase
H1343_RS03850	COG2309	aminopeptidase activity
H1343_RS03855	COG1335	isochorismatase
H1343_RS03865	COG4145	pantothenate transmembrane transporter activity
H1343_RS03870	COG1846	Transcriptional regulator
H1343_RS03875	COG2080	2 iron, 2 sulfur cluster binding
H1343_RS03880	COG2010	Cytochrome c
H1343_RS03880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1343_RS03885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1343_RS03905	COG1902	pentaerythritol trinitrate reductase activity
H1343_RS03915	COG3842	ATPase activity
H1343_RS03925	COG1175	transmembrane transport
H1343_RS03945	COG2205	protein histidine kinase activity
H1343_RS03950	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H1343_RS03955	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H1343_RS03960	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H1343_RS03980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1343_RS04035	COG0726	polysaccharide deacetylase
H1343_RS04065	COG1215	transferase activity, transferring glycosyl groups
H1343_RS04100	COG1204	response to ionizing radiation
H1343_RS04115	COG2357	RelA SpoT domain protein
H1343_RS04140	COG2948	multi-organism process
H1343_RS04160	COG1733	regulation of RNA biosynthetic process
H1343_RS04195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H1343_RS04200	COG1744	ABC transporter substrate-binding protein PnrA-like
H1343_RS04205	COG2900	Belongs to the SlyX family
H1343_RS04210	COG3845	ABC transporter
H1343_RS04215	COG1079	Belongs to the binding-protein-dependent transport system permease family
H1343_RS04220	COG1079	Belongs to the binding-protein-dependent transport system permease family
H1343_RS04230	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H1343_RS04240	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H1343_RS04250	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H1343_RS04280	COG4964	Belongs to the GSP D family
H1343_RS04315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H1343_RS04345	COG4172	Belongs to the ABC transporter superfamily
H1343_RS04355	COG4239	(ABC) transporter, permease
H1343_RS04360	COG4174	ABC transporter (Permease)
H1343_RS04365	COG4166	transmembrane transport
H1343_RS04370	COG4166	transmembrane transport
H1343_RS04375	COG3474	cytochrome
H1343_RS04395	COG2816	NAD+ diphosphatase activity
H1343_RS04415	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H1343_RS04420	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H1343_RS04425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H1343_RS04445	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H1343_RS04450	COG1473	amidohydrolase
H1343_RS04465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1343_RS04475	COG0242	peptide deformylase activity
H1343_RS04480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H1343_RS04485	COG0101	tRNA pseudouridine synthase activity
H1343_RS04495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H1343_RS04505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H1343_RS04510	COG2171	N-acyltransferase activity
H1343_RS04525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H1343_RS04545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1343_RS04550	COG0444	Belongs to the ABC transporter superfamily
H1343_RS04555	COG4608	Belongs to the ABC transporter superfamily
H1343_RS04565	COG0475	glutathione-regulated potassium exporter activity
H1343_RS04565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1343_RS04575	COG0586	Pfam SNARE associated Golgi protein
H1343_RS04585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H1343_RS04600	COG2186	Transcriptional regulator
H1343_RS04620	COG0129	dihydroxy-acid dehydratase activity
H1343_RS04625	COG3386	PFAM SMP-30 Gluconolaconase
H1343_RS04630	COG4213	ABC transporter substrate-binding protein
H1343_RS04640	COG4214	carbohydrate transport
H1343_RS04645	COG1505	serine-type exopeptidase activity
H1343_RS04650	COG1960	acyl-CoA dehydrogenase activity
H1343_RS04665	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1343_RS04665	COG1902	pentaerythritol trinitrate reductase activity
H1343_RS04680	COG2207	Transcriptional regulator
H1343_RS04695	COG0395	ABC-type sugar transport system, permease component
H1343_RS04700	COG1175	transmembrane transport
H1343_RS04705	COG3842	ATPase activity
H1343_RS04720	COG0523	cobalamin synthesis protein
H1343_RS04725	COG3443	Belongs to the bacterial solute-binding protein 9 family
H1343_RS04730	COG0803	Belongs to the bacterial solute-binding protein 9 family
H1343_RS04745	COG0438	transferase activity, transferring glycosyl groups
H1343_RS04785	COG5001	Diguanylate cyclase
H1343_RS04785	COG3300	MHYT domain
H1343_RS04795	COG1294	oxidase, subunit
H1343_RS04800	COG1271	oxidase subunit
H1343_RS04805	COG4988	ABC transporter
H1343_RS04810	COG1132	(ABC) transporter
H1343_RS04815	COG4566	intracellular signal transduction
H1343_RS04820	COG4566	intracellular signal transduction
H1343_RS04825	COG4191	Histidine kinase
H1343_RS04840	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H1343_RS04855	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H1343_RS04860	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H1343_RS04870	COG1477	protein flavinylation
H1343_RS04880	COG0517	IMP dehydrogenase activity
H1343_RS04880	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H1343_RS04880	COG0617	tRNA 3'-terminal CCA addition
H1343_RS04900	COG1063	alcohol dehydrogenase
H1343_RS04915	COG0765	amino acid transport
H1343_RS04920	COG0765	amino acid transport
H1343_RS04925	COG1028	Short-chain dehydrogenase reductase Sdr
H1343_RS04930	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H1343_RS04935	COG1802	Transcriptional regulator
H1343_RS05015	COG2205	protein histidine kinase activity
H1343_RS05020	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H1343_RS05025	COG0594	ribonuclease P activity
H1343_RS05030	COG0706	membrane insertase activity
H1343_RS05040	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H1343_RS05050	COG5328	Belongs to the UPF0262 family
H1343_RS05055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H1343_RS05100	COG0129	dihydroxy-acid dehydratase activity
H1343_RS05105	COG0363	glucosamine-6-phosphate deaminase activity
H1343_RS05110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H1343_RS05115	COG4251	negative regulation of phosphorylation
H1343_RS05125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1343_RS05140	COG2224	Isocitrate lyase
H1343_RS05165	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1343_RS05170	COG1177	transmembrane transport
H1343_RS05185	COG2205	protein histidine kinase activity
H1343_RS05210	COG1570	exodeoxyribonuclease VII activity
H1343_RS05215	COG0583	DNA-binding transcription factor activity
H1343_RS05225	COG1253	flavin adenine dinucleotide binding
H1343_RS05245	COG1028	Short-chain dehydrogenase reductase Sdr
H1343_RS05260	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H1343_RS05265	COG0277	FAD linked oxidase domain protein
H1343_RS05270	COG0277	FAD linked oxidase domain protein
H1343_RS05275	COG0247	lactate metabolic process
H1343_RS05280	COG1376	ErfK ybiS ycfS ynhG family protein
H1343_RS05285	COG1388	LysM domain
H1343_RS05285	COG1376	ErfK ybiS ycfS ynhG family protein
H1343_RS05295	COG2818	Glycosylase
H1343_RS05300	COG0124	histidyl-tRNA synthetase
H1343_RS05305	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H1343_RS05325	COG3237	CsbD-like
H1343_RS05330	COG0730	response to heat
H1343_RS05335	COG0459	protein refolding
H1343_RS05350	COG0196	riboflavin kinase activity
H1343_RS05355	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H1343_RS05365	COG0590	tRNA wobble adenosine to inosine editing
H1343_RS05370	COG1187	pseudouridine synthase activity
H1343_RS05375	COG0742	ribosomal rna small subunit methyltransferase
H1343_RS05380	COG0612	Peptidase, M16
H1343_RS05385	COG0612	Peptidase, M16
H1343_RS05390	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1343_RS05405	COG0312	modulator of DNA gyrase
H1343_RS05425	COG1519	Transferase
H1343_RS05430	COG1663	tetraacyldisaccharide 4'-kinase activity
H1343_RS05440	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H1343_RS05445	COG1523	belongs to the glycosyl hydrolase 13 family
H1343_RS05455	COG0033	Phosphoglucomutase
H1343_RS05460	COG0297	glycogen (starch) synthase activity
H1343_RS05465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H1343_RS05470	COG0058	SHG alpha-glucan phosphorylase activity
H1343_RS05475	COG0166	Belongs to the GPI family
H1343_RS05485	COG0729	surface antigen
H1343_RS05505	COG2382	esterase
H1343_RS05515	COG1294	oxidase, subunit
H1343_RS05520	COG1271	oxidase subunit
H1343_RS05550	COG1562	ergosterol biosynthetic process
H1343_RS05565	COG1304	FMN binding
H1343_RS05570	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H1343_RS05575	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H1343_RS05605	COG1320	monovalent cation:proton antiporter activity
H1343_RS05610	COG2212	antiporter activity
H1343_RS05615	COG1863	multisubunit Na H antiporter MnhE subunit
H1343_RS05620	COG0651	ATP synthesis coupled electron transport
H1343_RS05625	COG1006	Multisubunit Na H antiporter MnhC subunit
H1343_RS05630	COG2111	Na H antiporter
H1343_RS05635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1343_RS05635	COG2111	Na H antiporter
H1343_RS05660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1343_RS05665	COG1012	belongs to the aldehyde dehydrogenase family
H1343_RS05675	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H1343_RS05695	COG0583	DNA-binding transcription factor activity
H1343_RS05700	COG2223	nitrite transmembrane transporter activity
H1343_RS05715	COG3383	formate dehydrogenase (NAD+) activity
H1343_RS05730	COG0583	DNA-binding transcription factor activity
H1343_RS05735	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1343_RS05740	COG0473	3-isopropylmalate dehydrogenase activity
H1343_RS05745	COG0583	DNA-binding transcription factor activity
H1343_RS05755	COG2514	catechol 2,3-dioxygenase activity
H1343_RS05790	COG0071	Belongs to the small heat shock protein (HSP20) family
H1343_RS05810	COG0069	glutamate synthase activity
H1343_RS05810	COG0070	glutamate synthase
H1343_RS05810	COG0067	glutamate synthase
H1343_RS05825	COG2951	lytic endotransglycosylase activity
H1343_RS05855	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H1343_RS05875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1343_RS05880	COG1960	acyl-CoA dehydrogenase activity
H1343_RS05885	COG1522	sequence-specific DNA binding
H1343_RS05895	COG0400	carboxylic ester hydrolase activity
H1343_RS05900	COG0346	lactoylglutathione lyase activity
H1343_RS05905	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H1343_RS05925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H1343_RS05925	COG2010	Cytochrome c
H1343_RS05930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H1343_RS05945	COG1012	belongs to the aldehyde dehydrogenase family
H1343_RS05950	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H1343_RS05965	COG1028	Short-chain dehydrogenase reductase Sdr
H1343_RS05990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H1343_RS05990	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1343_RS06020	COG1802	Transcriptional regulator
H1343_RS06035	COG2267	carboxylic ester hydrolase activity
H1343_RS06050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1343_RS06075	COG0784	Response regulator, receiver
H1343_RS06080	COG0586	Pfam SNARE associated Golgi protein
H1343_RS06095	COG0640	Transcriptional regulator
H1343_RS06140	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H1343_RS06160	COG2001	Belongs to the MraZ family
H1343_RS06165	COG0275	rRNA processing
H1343_RS06180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H1343_RS06190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H1343_RS06195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H1343_RS06215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H1343_RS06220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H1343_RS06250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H1343_RS06260	COG0330	HflC and HflK could
H1343_RS06275	COG0560	Phosphoserine phosphatase
H1343_RS06280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H1343_RS06290	COG0028	Belongs to the TPP enzyme family
H1343_RS06295	COG0440	acetolactate synthase activity
H1343_RS06305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1343_RS06315	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H1343_RS06325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H1343_RS06345	COG4172	Belongs to the ABC transporter superfamily
H1343_RS06350	COG0747	negative chemotaxis
H1343_RS06355	COG0601	transmembrane transport
H1343_RS06360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1343_RS06370	COG1234	tRNA 3'-trailer cleavage
H1343_RS06380	COG1132	(ABC) transporter
H1343_RS06385	COG0438	transferase activity, transferring glycosyl groups
H1343_RS06410	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1343_RS06425	COG0546	phosphoglycolate phosphatase activity
H1343_RS06425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H1343_RS06440	COG1088	dTDP-glucose 4,6-dehydratase activity
H1343_RS06470	COG4176	ABC-type proline glycine betaine transport system permease component
H1343_RS06475	COG0784	Response regulator, receiver
H1343_RS06480	COG5001	Diguanylate cyclase
H1343_RS06495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1343_RS06505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1343_RS06510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1343_RS06515	COG0730	response to heat
H1343_RS06540	COG1573	uracil-dna glycosylase
H1343_RS06545	COG1522	sequence-specific DNA binding
H1343_RS06560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1343_RS06565	COG0746	molybdenum cofactor guanylyltransferase activity
H1343_RS06570	COG2814	Major facilitator Superfamily
H1343_RS06575	COG0697	spore germination
H1343_RS06585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H1343_RS06605	COG2308	Evidence 4 Homologs of previously reported genes of
H1343_RS06610	COG1686	Belongs to the peptidase S11 family
H1343_RS06630	COG0438	transferase activity, transferring glycosyl groups
H1343_RS06640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1343_RS06665	COG1686	Belongs to the peptidase S11 family
H1343_RS06670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1343_RS06675	COG0028	Belongs to the TPP enzyme family
H1343_RS06690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1343_RS06710	COG0511	ligase activity, forming carbon-carbon bonds
H1343_RS06725	COG0436	Aminotransferase
H1343_RS06730	COG1530	ribonuclease E activity
H1343_RS06735	COG0860	N-Acetylmuramoyl-L-alanine amidase
H1343_RS06740	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H1343_RS06760	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H1343_RS06775	COG0557	exoribonuclease II activity
H1343_RS06785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H1343_RS06785	COG1754	DNA topoisomerase type I activity
H1343_RS06790	COG0758	DNA mediated transformation
H1343_RS06795	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H1343_RS06800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H1343_RS06805	COG0540	Belongs to the ATCase OTCase family
H1343_RS06815	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H1343_RS06820	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H1343_RS06825	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1343_RS06860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H1343_RS06870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1343_RS06875	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H1343_RS06880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H1343_RS06900	COG1181	Belongs to the D-alanine--D-alanine ligase family
H1343_RS06905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H1343_RS06910	COG0849	cell division
H1343_RS06915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H1343_RS06925	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H1343_RS06930	COG0497	DNA recombination
H1343_RS06940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H1343_RS06985	COG2264	protein methyltransferase activity
H1343_RS06990	COG1999	signal sequence binding
H1343_RS07010	COG1960	acyl-CoA dehydrogenase activity
H1343_RS07015	COG0210	DNA helicase
H1343_RS07040	COG1160	GTP binding
H1343_RS07055	COG0356	it plays a direct role in the translocation of protons across the membrane
H1343_RS07060	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H1343_RS07065	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H1343_RS07070	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H1343_RS07075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H1343_RS07090	COG0521	Mo-molybdopterin cofactor biosynthetic process
H1343_RS07095	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H1343_RS07105	COG0142	geranyltranstransferase activity
H1343_RS07130	COG0752	glycyl-tRNA synthetase alpha subunit
H1343_RS07135	COG2321	neutral zinc metallopeptidase
H1343_RS07140	COG0751	glycine-tRNA ligase activity
H1343_RS07150	COG0009	L-threonylcarbamoyladenylate synthase
H1343_RS07170	COG0151	Belongs to the GarS family
H1343_RS07175	COG1960	acyl-CoA dehydrogenase activity
H1343_RS07180	COG0183	Belongs to the thiolase family
H1343_RS07190	COG1960	acyl-CoA dehydrogenase activity
H1343_RS07195	COG1024	Enoyl-CoA hydratase
H1343_RS07200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H1343_RS07210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H1343_RS07215	COG1722	exodeoxyribonuclease VII activity
H1343_RS07220	COG0123	including yeast histone deacetylase and acetoin utilization protein
H1343_RS07235	COG0406	alpha-ribazole phosphatase activity
H1343_RS07240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H1343_RS07245	COG0484	heat shock protein binding
H1343_RS07260	COG0312	modulator of DNA gyrase
H1343_RS07275	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H1343_RS07280	COG0109	protoheme IX farnesyltransferase activity
H1343_RS07290	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H1343_RS07310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H1343_RS07315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H1343_RS07320	COG0328	RNA-DNA hybrid ribonuclease activity
H1343_RS07335	COG1678	Uncharacterized ACR, COG1678
H1343_RS07340	COG5001	Diguanylate cyclase
H1343_RS07350	COG0612	Peptidase, M16
H1343_RS07365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1343_RS07375	COG1194	a g-specific adenine glycosylase
H1343_RS07395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1343_RS07400	COG0574	Belongs to the PEP-utilizing enzyme family
H1343_RS07400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H1343_RS07415	COG0028	Belongs to the TPP enzyme family
H1343_RS07420	COG1012	belongs to the aldehyde dehydrogenase family
H1343_RS07430	COG1121	(ABC) transporter
H1343_RS07440	COG4221	oxidoreductase activity
H1343_RS07445	COG3387	PFAM Glycoside hydrolase 15-related
H1343_RS07450	COG1028	Short-chain dehydrogenase reductase Sdr
H1343_RS07455	COG1802	Transcriptional regulator
H1343_RS07465	COG3246	L-lysine catabolic process to acetate
H1343_RS07470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H1343_RS07475	COG1028	Short-chain dehydrogenase reductase Sdr
H1343_RS07480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H1343_RS07490	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H1343_RS07490	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H1343_RS07510	COG1960	acyl-CoA dehydrogenase activity
H1343_RS07515	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H1343_RS07530	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1343_RS07530	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1343_RS07535	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H1343_RS07540	COG0861	Integral membrane protein TerC family
H1343_RS07545	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H1343_RS07550	COG1363	Peptidase, m42
H1343_RS07555	COG0189	ligase activity
H1343_RS07555	COG2918	glutathione biosynthetic process
H1343_RS07560	COG0367	asparagine synthase
H1343_RS07570	COG0546	phosphoglycolate phosphatase activity
H1343_RS07600	COG1793	dna ligase
H1343_RS07610	COG0123	including yeast histone deacetylase and acetoin utilization protein
H1343_RS07615	COG0167	dihydroorotate dehydrogenase activity
H1343_RS07625	COG0657	acetylesterase activity
H1343_RS07630	COG0432	Pfam Uncharacterised protein family UPF0047
H1343_RS07635	COG1970	mechanosensitive ion channel activity
H1343_RS07640	COG0436	Aminotransferase
H1343_RS07655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H1343_RS07665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H1343_RS07670	COG0081	regulation of translation
H1343_RS07675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H1343_RS07680	COG0222	ribosome binding
H1343_RS07685	COG0085	RNA polymerase activity
H1343_RS07690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H1343_RS07695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H1343_RS07700	COG0049	tRNA binding
H1343_RS07705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H1343_RS07710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H1343_RS07715	COG0051	transcription antitermination factor activity, RNA binding
H1343_RS07725	COG0088	Forms part of the polypeptide exit tunnel
H1343_RS07735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H1343_RS07740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H1343_RS07750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H1343_RS07755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H1343_RS07765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H1343_RS07770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H1343_RS07775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H1343_RS07780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H1343_RS07785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H1343_RS07800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H1343_RS07805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H1343_RS07810	COG1841	ribosomal large subunit assembly
H1343_RS07815	COG0200	Binds to the 23S rRNA
H1343_RS07820	COG0201	protein transport
H1343_RS07825	COG0563	adenylate kinase activity
H1343_RS07830	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H1343_RS07845	COG0203	ribosomal protein L17
H1343_RS07855	COG1115	amino acid carrier protein
H1343_RS07880	COG2113	Glycine betaine
H1343_RS07885	COG2188	Transcriptional regulator
H1343_RS07890	COG3624	Phosphonate C-P lyase system protein PhnG
H1343_RS07895	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
H1343_RS07900	COG3626	phosphonate metabolism
H1343_RS07905	COG3627	carbon phosphorus lyase activity
H1343_RS07910	COG4107	phosphonate C-P lyase system protein PhnK
H1343_RS07915	COG4778	phosphonate C-P lyase system protein PhnL
H1343_RS07930	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H1343_RS07935	COG3639	organic phosphonate transmembrane transporter activity
H1343_RS07940	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H1343_RS07945	COG3454	Phosphonate metabolism
H1343_RS07950	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H1343_RS07985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H1343_RS07990	COG1216	Glycosyl transferase, family 2
H1343_RS07990	COG0438	transferase activity, transferring glycosyl groups
H1343_RS07995	COG1091	dTDP-4-dehydrorhamnose reductase activity
H1343_RS08000	COG1088	dTDP-glucose 4,6-dehydratase activity
H1343_RS08050	COG2259	Doxx family
H1343_RS08065	COG1960	acyl-CoA dehydrogenase activity
H1343_RS08075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H1343_RS08080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H1343_RS08095	COG3106	COG3106 Predicted ATPase
H1343_RS08115	COG0628	permease
H1343_RS08135	COG0596	Alpha beta hydrolase
H1343_RS08170	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1343_RS08175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H1343_RS08180	COG0302	gtp cyclohydrolase
H1343_RS08195	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H1343_RS08200	COG2971	BadF BadG BcrA BcrD
H1343_RS08210	COG1596	polysaccharide export
H1343_RS08225	COG1612	heme a metabolic process
H1343_RS08230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H1343_RS08235	COG0010	Belongs to the arginase family
H1343_RS08240	COG0598	Magnesium transport protein CorA
H1343_RS08245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H1343_RS08250	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H1343_RS08260	COG2326	polyphosphate kinase activity
H1343_RS08295	COG1671	Belongs to the UPF0178 family
H1343_RS08300	COG0321	lipoyl(octanoyl) transferase activity
H1343_RS08310	COG2239	Acts as a magnesium transporter
H1343_RS08325	COG0656	L-ascorbic acid biosynthetic process
H1343_RS08355	COG0484	heat shock protein binding
H1343_RS08360	COG1686	Belongs to the peptidase S11 family
H1343_RS08370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H1343_RS08400	COG4589	Belongs to the CDS family
H1343_RS08405	COG0537	adenosine 5'-monophosphoramidase activity
H1343_RS08430	COG0052	Belongs to the universal ribosomal protein uS2 family
H1343_RS08435	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H1343_RS08440	COG0528	UMP kinase activity
H1343_RS08445	COG0233	cytoplasmic translational termination
H1343_RS08450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H1343_RS08460	COG0750	zinc metalloprotease
H1343_RS08470	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1343_RS08475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H1343_RS08480	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1343_RS08490	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1343_RS08495	COG0372	Belongs to the citrate synthase family
H1343_RS08505	COG0658	competence protein
H1343_RS08505	COG2333	competence protein COMEC
H1343_RS08510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H1343_RS08515	COG0303	'Molybdopterin
H1343_RS08520	COG0315	cyclic pyranopterin monophosphate synthase activity
H1343_RS08525	COG0134	indole-3-glycerol-phosphate synthase activity
H1343_RS08530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H1343_RS08540	COG0149	triose-phosphate isomerase activity
H1343_RS08550	COG0504	CTP synthase activity
H1343_RS08565	COG0148	phosphopyruvate hydratase activity
H1343_RS08575	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H1343_RS08580	COG0022	dehydrogenase e1 component
H1343_RS08580	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1343_RS08585	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1343_RS08590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1343_RS08600	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1343_RS08605	COG2867	negative regulation of translational initiation
H1343_RS08610	COG1058	Belongs to the CinA family
H1343_RS08610	COG1546	Belongs to the CinA family
H1343_RS08615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H1343_RS08615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H1343_RS08625	COG3852	Histidine kinase
H1343_RS08630	COG2204	response regulator
H1343_RS08635	COG5000	phosphorelay sensor kinase activity
H1343_RS08640	COG2204	response regulator
H1343_RS08645	COG0569	domain protein
H1343_RS08655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H1343_RS08660	COG3956	TIGRFAM MazG family protein
H1343_RS08670	COG0084	hydrolase, TatD family'
H1343_RS08690	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H1343_RS08695	COG1686	Belongs to the peptidase S11 family
H1343_RS08710	COG1283	sodium-dependent phosphate transmembrane transporter activity
H1343_RS08725	COG1741	Belongs to the pirin family
H1343_RS08730	COG0583	DNA-binding transcription factor activity
H1343_RS08735	COG1335	isochorismatase
H1343_RS08760	COG1183	phosphatidylcholine synthase activity
H1343_RS08765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1343_RS08920	COG1028	Short-chain dehydrogenase reductase Sdr
H1343_RS08950	COG0318	PFAM AMP-dependent synthetase and ligase
H1343_RS08955	COG1414	Transcriptional regulator
H1343_RS09065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1343_RS09120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1343_RS09145	COG3850	Histidine kinase
H1343_RS09145	COG5002	protein histidine kinase activity
H1343_RS09150	COG0745	RESPONSE REGULATOR receiver
H1343_RS09160	COG4166	transmembrane transport
H1343_RS09170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H1343_RS09175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H1343_RS09180	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H1343_RS09190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H1343_RS09195	COG0785	Cytochrome C biogenesis protein
H1343_RS09210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H1343_RS09225	COG0708	Exodeoxyribonuclease III
H1343_RS09275	COG0784	Response regulator, receiver
H1343_RS09435	COG0582	viral genome integration into host DNA
H1343_RS09440	COG1028	Short-chain dehydrogenase reductase Sdr
H1343_RS09450	COG3546	catalase activity
H1343_RS09460	COG1278	Cold shock
H1343_RS09475	COG2066	Belongs to the glutaminase family
H1343_RS09480	COG0343	queuine tRNA-ribosyltransferase activity
H1343_RS09485	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H1343_RS09500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H1343_RS09510	COG2095	MarC family integral membrane protein
H1343_RS09515	COG0629	single-stranded DNA binding
H1343_RS09520	COG0346	lactoylglutathione lyase activity
H1343_RS09525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H1343_RS09535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H1343_RS09535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H1343_RS09540	COG0347	Belongs to the P(II) protein family
H1343_RS09545	COG0174	glutamine synthetase
H1343_RS09550	COG0187	DNA topoisomerase II activity
H1343_RS09575	COG0316	Belongs to the HesB IscA family
H1343_RS09580	COG2151	metal-sulfur cluster biosynthetic enzyme
H1343_RS09585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H1343_RS09590	COG0719	Fe-S assembly protein
H1343_RS09595	COG0396	ATPase activity
H1343_RS09605	COG0719	Fe-S assembly protein
H1343_RS09615	COG2945	thiolester hydrolase activity
H1343_RS09620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H1343_RS09630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H1343_RS09635	COG2833	Protein of unknown function (DUF455)
H1343_RS09640	COG0739	heme binding
H1343_RS09650	COG1278	Cold shock
H1343_RS09675	COG0583	DNA-binding transcription factor activity
H1343_RS09680	COG2197	response regulator
H1343_RS09690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1343_RS09695	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
H1343_RS09700	COG3250	beta-galactosidase activity
H1343_RS09705	COG1054	Belongs to the UPF0176 family
H1343_RS09710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1343_RS09710	COG0519	Catalyzes the synthesis of GMP from XMP
H1343_RS09725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H1343_RS09725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H1343_RS09730	COG0753	catalase activity
H1343_RS09740	COG1285	pathogenesis
H1343_RS09755	COG0477	Major facilitator Superfamily
H1343_RS09760	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H1343_RS09780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H1343_RS09785	COG1494	fructose-1,6-bisphosphatase
H1343_RS09795	COG0436	Aminotransferase
H1343_RS09805	COG3243	poly(R)-hydroxyalkanoic acid synthase
H1343_RS09810	COG0024	Methionine aminopeptidase
H1343_RS09815	COG2003	Belongs to the UPF0758 family
H1343_RS09820	COG5425	PFAM Usg family protein
H1343_RS09825	COG2068	MobA-Related Protein
H1343_RS09830	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H1343_RS09830	COG3608	succinylglutamate desuccinylase aspartoacylase
H1343_RS09840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1343_RS09850	COG0410	ABC transporter
H1343_RS09875	COG3191	aminopeptidase activity
H1343_RS09885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H1343_RS09900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1343_RS09920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H1343_RS09925	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H1343_RS09930	COG0047	phosphoribosylformylglycinamidine synthase activity
H1343_RS09950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H1343_RS09960	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H1343_RS09965	COG2814	Major facilitator Superfamily
H1343_RS09970	COG0037	tRNA processing
H1343_RS09975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H1343_RS09990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1343_RS10000	COG0538	isocitrate dehydrogenase activity
H1343_RS10010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H1343_RS10030	COG0633	Ferredoxin
H1343_RS10040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H1343_RS10040	COG3218	ABC-type transport auxiliary lipoprotein component
H1343_RS10050	COG1127	ABC transporter
H1343_RS10055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H1343_RS10060	COG4948	Mandelate Racemase Muconate Lactonizing
H1343_RS10065	COG0280	phosphate acetyltransferase
H1343_RS10065	COG0281	malic enzyme
H1343_RS10070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1343_RS10070	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
H1343_RS10085	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H1343_RS10095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H1343_RS10110	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H1343_RS10115	COG0546	phosphoglycolate phosphatase activity
H1343_RS10130	COG0494	nUDIX hydrolase
H1343_RS10150	COG4221	oxidoreductase activity
H1343_RS10165	COG4221	oxidoreductase activity
H1343_RS10170	COG2207	Transcriptional regulator
H1343_RS10280	COG4626	Terminase
H1343_RS10280	COG1802	Transcriptional regulator
H1343_RS10315	COG2200	EAL domain
H1343_RS10335	COG0328	RNA-DNA hybrid ribonuclease activity
H1343_RS10405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H1343_RS10430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1343_RS10435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1343_RS10440	COG1126	abc transporter atp-binding protein
H1343_RS10445	COG0765	amino acid transport
H1343_RS10450	COG0165	Argininosuccinate lyase
H1343_RS10455	COG0583	DNA-binding transcription factor activity
H1343_RS10460	COG1126	abc transporter atp-binding protein
H1343_RS10465	COG0765	amino acid transport
H1343_RS10470	COG4597	amino acid ABC transporter
H1343_RS10475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1343_RS10480	COG0626	cystathionine gamma-synthase activity
H1343_RS10515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H1343_RS10535	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H1343_RS10540	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H1343_RS10550	COG1278	Cold shock
H1343_RS10555	COG3300	MHYT domain
H1343_RS10555	COG5001	Diguanylate cyclase
H1343_RS10560	COG0535	radical SAM domain protein
H1343_RS10570	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H1343_RS10575	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H1343_RS10595	COG0747	negative chemotaxis
H1343_RS10600	COG0601	transmembrane transport
H1343_RS10605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1343_RS10620	COG1473	amidohydrolase
H1343_RS10630	COG0776	regulation of translation
H1343_RS10640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H1343_RS10645	COG0740	serine-type endopeptidase activity
H1343_RS10650	COG0668	transmembrane transport
H1343_RS10655	COG0544	peptidyl-prolyl cis-trans isomerase activity
H1343_RS10670	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H1343_RS10685	COG3737	Protein of unknown function (DUF498/DUF598)
H1343_RS10695	COG1862	Preprotein translocase
H1343_RS10710	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H1343_RS10715	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H1343_RS10720	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H1343_RS10725	COG0805	protein transport
H1343_RS10730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H1343_RS10735	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H1343_RS10740	COG1472	Belongs to the glycosyl hydrolase 3 family
H1343_RS10750	COG0018	arginyl-trna synthetase
H1343_RS10760	COG0316	Belongs to the HesB IscA family
H1343_RS10770	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H1343_RS10795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H1343_RS10805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H1343_RS10830	COG0747	negative chemotaxis
H1343_RS10840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1343_RS10845	COG0444	Belongs to the ABC transporter superfamily
H1343_RS10850	COG4608	Belongs to the ABC transporter superfamily
H1343_RS10860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H1343_RS10865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1343_RS10875	COG0156	8-amino-7-oxononanoate synthase activity
H1343_RS10905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H1343_RS10935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1343_RS10950	COG0442	prolyl-tRNA aminoacylation
H1343_RS10970	COG1007	ATP synthesis coupled electron transport
H1343_RS10985	COG0713	ATP synthesis coupled electron transport
H1343_RS11000	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H1343_RS11010	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H1343_RS11015	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H1343_RS11020	COG0649	NAD binding
H1343_RS11035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1343_RS11040	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1343_RS11045	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1343_RS11060	COG2080	2 iron, 2 sulfur cluster binding
H1343_RS11065	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H1343_RS11070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1343_RS11220	COG0250	Participates in transcription elongation, termination and antitermination
H1343_RS11340	COG0747	negative chemotaxis
H1343_RS11345	COG0601	transmembrane transport
H1343_RS11350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1343_RS11385	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H1343_RS11385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H1343_RS11390	COG1309	transcriptional regulator
H1343_RS11415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H1343_RS11425	COG2274	protein secretion by the type I secretion system
H1343_RS11465	COG3706	GGDEF domain
H1343_RS11500	COG1959	2 iron, 2 sulfur cluster binding
H1343_RS11535	COG1070	Carbohydrate kinase
H1343_RS11540	COG2115	Belongs to the xylose isomerase family
H1343_RS11550	COG4213	ABC transporter substrate-binding protein
H1343_RS11555	COG4214	carbohydrate transport
H1343_RS11560	COG1129	ABC transporter
H1343_RS11570	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H1343_RS11575	COG4423	Transcription factor
H1343_RS11585	COG1268	BioY protein
H1343_RS11590	COG1122	ATPase activity
H1343_RS11595	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H1343_RS11620	COG0215	cysteine-tRNA ligase activity
H1343_RS11655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H1343_RS11665	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H1343_RS11680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H1343_RS11685	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H1343_RS11690	COG1381	Involved in DNA repair and RecF pathway recombination
H1343_RS11695	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H1343_RS11705	COG0681	Belongs to the peptidase S26 family
H1343_RS11710	COG0736	holo-[acyl-carrier-protein] synthase activity
H1343_RS11720	COG1758	RNA polymerase activity
H1343_RS11725	COG1573	uracil-dna glycosylase
H1343_RS11740	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H1343_RS11745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1343_RS11750	COG0741	lytic transglycosylase activity
H1343_RS11765	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H1343_RS11775	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H1343_RS11790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H1343_RS11810	COG0625	glutathione transferase activity
H1343_RS11820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H1343_RS11840	COG0697	spore germination
H1343_RS11850	COG1573	uracil-dna glycosylase
H1343_RS11855	COG0477	Major facilitator Superfamily
H1343_RS11865	COG0308	aminopeptidase N
H1343_RS11870	COG2202	Pas domain
H1343_RS11870	COG2205	protein histidine kinase activity
H1343_RS11880	COG4221	oxidoreductase activity
H1343_RS11890	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H1343_RS11900	COG0745	RESPONSE REGULATOR receiver
H1343_RS11905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1343_RS11920	COG3088	subunit of a heme lyase
H1343_RS11925	COG1138	Cytochrome C-type biogenesis protein
H1343_RS11930	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H1343_RS11935	COG4235	cytochrome complex assembly
H1343_RS12035	COG4695	Portal protein
H1343_RS12050	COG2983	Belongs to the UPF0260 family
H1343_RS12085	COG2205	protein histidine kinase activity
H1343_RS12095	COG2166	iron-sulfur cluster assembly
H1343_RS12120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1343_RS12125	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H1343_RS12130	COG2080	2 iron, 2 sulfur cluster binding
H1343_RS12135	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H1343_RS12140	COG0534	Mate efflux family protein
H1343_RS12165	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H1343_RS12170	COG1879	ABC-type sugar transport system periplasmic component
H1343_RS12175	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1343_RS12180	COG1129	ABC transporter
H1343_RS12210	COG1522	sequence-specific DNA binding
H1343_RS12215	COG2814	Major facilitator Superfamily
H1343_RS12280	COG3585	molybdate ion transport
H1343_RS12315	COG2897	thiosulfate sulfurtransferase activity
H1343_RS12330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1343_RS12335	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H1343_RS12350	COG0655	NAD(P)H dehydrogenase (quinone) activity
H1343_RS12355	COG1058	Belongs to the CinA family
H1343_RS12355	COG1546	Belongs to the CinA family
H1343_RS12365	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H1343_RS12370	COG1902	pentaerythritol trinitrate reductase activity
H1343_RS12380	COG1785	Belongs to the alkaline phosphatase family
H1343_RS12390	COG1136	(ABC) transporter
H1343_RS12400	COG3011	Protein conserved in bacteria
H1343_RS12415	COG0745	RESPONSE REGULATOR receiver
H1343_RS12435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1343_RS12440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1343_RS12450	COG0776	regulation of translation
H1343_RS12455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H1343_RS12460	COG0416	fatty acid biosynthetic process
H1343_RS12480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H1343_RS12495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1343_RS12495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1343_RS12500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H1343_RS12505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H1343_RS12525	COG0113	porphobilinogen synthase activity
H1343_RS12540	COG1846	Transcriptional regulator
H1343_RS12550	COG4771	TonB-dependent receptor
H1343_RS12570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H1343_RS12590	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H1343_RS12605	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H1343_RS12615	COG0628	permease
H1343_RS12620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H1343_RS12625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H1343_RS12640	COG0243	molybdopterin cofactor binding
H1343_RS12645	COG1902	pentaerythritol trinitrate reductase activity
H1343_RS12650	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H1343_RS12660	COG0625	glutathione transferase activity
H1343_RS12670	COG0322	excinuclease ABC activity
H1343_RS12675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H1343_RS12685	COG0314	molybdopterin synthase activity
H1343_RS12690	COG0105	UTP biosynthetic process
H1343_RS12710	COG0488	(ABC) transporter
H1343_RS12725	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H1343_RS12740	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H1343_RS12750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H1343_RS12755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H1343_RS12760	COG0194	GDP metabolic process
H1343_RS12765	COG1561	YicC-like family, N-terminal region
H1343_RS12770	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H1343_RS12775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1343_RS12780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1343_RS12790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H1343_RS12795	COG0360	Binds together with S18 to 16S ribosomal RNA
H1343_RS12810	COG0359	binds to the 23S rRNA
H1343_RS12815	COG0305	Participates in initiation and elongation during chromosome replication
H1343_RS12820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1343_RS12835	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H1343_RS12840	COG1028	Short-chain dehydrogenase reductase Sdr
H1343_RS12845	COG1183	phosphatidylcholine synthase activity
H1343_RS12850	COG0688	phosphatidylethanolamine metabolic process
H1343_RS12855	COG5265	(ABC) transporter
H1343_RS12875	COG0482	sulfurtransferase activity
H1343_RS12890	COG0745	RESPONSE REGULATOR receiver
H1343_RS12920	COG4206	TonB-dependent receptor
H1343_RS12930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1343_RS12935	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H1343_RS12950	COG1596	polysaccharide export
H1343_RS12955	COG3307	-O-antigen
H1343_RS12960	COG1216	Glycosyl transferase, family 2
H1343_RS12965	COG0463	Glycosyl transferase, family 2
H1343_RS12970	COG5039	Polysaccharide pyruvyl transferase
H1343_RS12975	COG2244	polysaccharide biosynthetic process
H1343_RS12980	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H1343_RS12985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H1343_RS13000	COG1215	transferase activity, transferring glycosyl groups
H1343_RS13005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1343_RS13010	COG2273	Hydrolase Family 16
H1343_RS13015	COG0438	transferase activity, transferring glycosyl groups
H1343_RS13020	COG1215	transferase activity, transferring glycosyl groups
H1343_RS13025	COG1215	transferase activity, transferring glycosyl groups
H1343_RS13030	COG1215	transferase activity, transferring glycosyl groups
H1343_RS13035	COG0489	protein tyrosine kinase activity
H1343_RS13035	COG3206	protein involved in exopolysaccharide biosynthesis
H1343_RS13050	COG0564	pseudouridine synthase activity
H1343_RS13055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H1343_RS13065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H1343_RS13075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1343_RS13105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1343_RS13110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1343_RS13115	COG0037	tRNA processing
H1343_RS13125	COG2885	chlorophyll binding
H1343_RS13130	COG0823	Involved in the tonB-independent uptake of proteins
H1343_RS13140	COG0848	biopolymer transport protein
H1343_RS13150	COG0824	Thioesterase
H1343_RS13160	COG2255	four-way junction helicase activity
H1343_RS13180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H1343_RS13195	COG0217	transcriptional regulatory protein
H1343_RS13205	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H1343_RS13210	COG1692	metallophosphoesterase
H1343_RS13215	COG0625	glutathione transferase activity
H1343_RS13225	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H1343_RS13235	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H1343_RS13255	COG0126	phosphoglycerate kinase activity
H1343_RS13260	COG3240	lipase activity
H1343_RS13265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1343_RS13300	COG1201	RNA secondary structure unwinding
H1343_RS13315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1343_RS13330	COG0730	response to heat
H1343_RS13345	COG1960	acyl-CoA dehydrogenase activity
H1343_RS13350	COG0183	Belongs to the thiolase family
H1343_RS13355	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1343_RS13355	COG1024	Enoyl-CoA hydratase
H1343_RS13360	COG1295	ribonuclease BN
H1343_RS13380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1343_RS13405	COG0848	biopolymer transport protein
H1343_RS13410	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H1343_RS13415	COG2832	Protein of unknown function (DUF454)
H1343_RS13435	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H1343_RS13440	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H1343_RS13445	COG4208	sulfate ABC transporter
H1343_RS13450	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H1343_RS13455	COG1720	tRNA m6t6A37 methyltransferase activity
H1343_RS13465	COG0717	Belongs to the dCTP deaminase family
H1343_RS13475	COG2967	ApaG domain
H1343_RS13480	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H1343_RS13485	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H1343_RS13490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1343_RS13505	COG0745	RESPONSE REGULATOR receiver
H1343_RS13510	COG0704	Plays a role in the regulation of phosphate uptake
H1343_RS13515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H1343_RS13525	COG0573	inorganic phosphate transmembrane transporter activity
H1343_RS13540	COG3387	PFAM Glycoside hydrolase 15-related
H1343_RS13555	COG0604	alcohol dehydrogenase
H1343_RS13555	COG3321	synthase
H1343_RS13555	COG1028	Short-chain dehydrogenase reductase Sdr
H1343_RS13580	COG0254	rRNA binding
H1343_RS13585	COG1132	(ABC) transporter
H1343_RS13600	COG0483	inositol monophosphate 1-phosphatase activity
H1343_RS13605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H1343_RS13630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H1343_RS13635	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H1343_RS13640	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H1343_RS13645	COG0457	Tetratricopeptide repeat
H1343_RS13650	COG0469	pyruvate kinase activity
H1343_RS13665	COG3750	Belongs to the UPF0335 family
H1343_RS13670	COG4957	zinc ion binding
H1343_RS13695	COG5310	Homospermidine synthase
H1343_RS13710	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H1343_RS13715	COG0330	HflC and HflK could
H1343_RS13725	COG0517	IMP dehydrogenase activity
H1343_RS13725	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H1343_RS13735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H1343_RS13750	COG1063	alcohol dehydrogenase
H1343_RS13755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H1343_RS13765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H1343_RS13770	COG1802	Transcriptional regulator
H1343_RS13775	COG1312	Catalyzes the dehydration of D-mannonate
H1343_RS13780	COG0246	Mannitol dehydrogenase
H1343_RS13790	COG3938	Belongs to the proline racemase family
H1343_RS13795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1343_RS13800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1343_RS13805	COG1802	Transcriptional regulator
H1343_RS13830	COG1177	transmembrane transport
H1343_RS13835	COG3842	ATPase activity
H1343_RS13845	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1343_RS13855	COG0444	Belongs to the ABC transporter superfamily
H1343_RS13860	COG4608	Belongs to the ABC transporter superfamily
H1343_RS13880	COG0601	transmembrane transport
H1343_RS13885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1343_RS13895	COG4251	negative regulation of phosphorylation
H1343_RS13910	COG4106	trans-aconitate 2-methyltransferase activity
H1343_RS13925	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H1343_RS13935	COG1120	ATPase activity
H1343_RS13940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1343_RS13945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1343_RS13955	COG4774	siderophore transport
H1343_RS13970	COG0318	PFAM AMP-dependent synthetase and ligase
H1343_RS13985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H1343_RS13990	COG0277	FAD linked oxidase domain protein
H1343_RS13990	COG0247	lactate metabolic process
H1343_RS13995	COG1802	Transcriptional regulator
H1343_RS14000	COG1024	Enoyl-CoA hydratase
H1343_RS14005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H1343_RS14010	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H1343_RS14010	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H1343_RS14020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H1343_RS14030	COG1309	transcriptional regulator
H1343_RS14050	COG3300	MHYT domain
H1343_RS14050	COG5001	Diguanylate cyclase
H1343_RS14055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H1343_RS14070	COG1346	cytolysis
H1343_RS14075	COG0505	Belongs to the CarA family
H1343_RS14090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H1343_RS14095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H1343_RS14100	COG0438	transferase activity, transferring glycosyl groups
H1343_RS14110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H1343_RS14115	COG5265	(ABC) transporter
H1343_RS14120	COG0492	ferredoxin-NADP+ reductase activity
H1343_RS14125	COG0583	DNA-binding transcription factor activity
H1343_RS14130	COG0513	Belongs to the DEAD box helicase family
H1343_RS14135	COG0436	Aminotransferase
H1343_RS14150	COG1607	acyl-coa hydrolase
H1343_RS14165	COG1376	ErfK ybiS ycfS ynhG family protein
H1343_RS14170	COG0556	nucleotide-excision repair
H1343_RS14180	COG0596	Alpha beta hydrolase
H1343_RS14190	COG1278	Cold shock
H1343_RS14200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1343_RS14210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1343_RS14215	COG1846	Transcriptional regulator
H1343_RS14220	COG0745	RESPONSE REGULATOR receiver
H1343_RS14230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1343_RS14250	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H1343_RS14285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H1343_RS14290	COG0193	aminoacyl-tRNA hydrolase activity
H1343_RS14300	COG2030	dehydratase
H1343_RS14310	COG2857	Cytochrome c1
H1343_RS14310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H1343_RS14325	COG1132	(ABC) transporter
H1343_RS14330	COG1132	(ABC) transporter
H1343_RS14335	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H1343_RS14355	COG0408	coproporphyrinogen oxidase activity
H1343_RS14365	COG0617	tRNA 3'-terminal CCA addition
H1343_RS14380	COG0714	Associated with various cellular activities
H1343_RS14410	COG0435	Glutathione S-transferase
H1343_RS14425	COG3135	benzoate transporter
H1343_RS14450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H1343_RS14455	COG0512	Glutamine amidotransferase of anthranilate synthase
H1343_RS14455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H1343_RS14470	COG4176	ABC-type proline glycine betaine transport system permease component
H1343_RS14480	COG0489	protein tyrosine kinase activity
H1343_RS14495	COG2202	Pas domain
H1343_RS14495	COG3920	Histidine kinase
H1343_RS14500	COG0784	Response regulator, receiver
H1343_RS14535	COG1597	lipid kinase activity
H1343_RS14535	COG1803	Methylglyoxal synthase
H1343_RS14550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1343_RS14555	COG0488	(ABC) transporter
H1343_RS14565	COG0513	Belongs to the DEAD box helicase family
H1343_RS14615	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H1343_RS14620	COG1733	regulation of RNA biosynthetic process
H1343_RS14640	COG5507	3-demethylubiquinone-9 3-methyltransferase
H1343_RS14650	COG4794	Type iii secretion
H1343_RS14655	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H1343_RS14660	COG5443	negative regulation of bacterial-type flagellum assembly
H1343_RS14665	COG5442	Flagellar protein FlaF
H1343_RS14700	COG1360	Flagellar Motor Protein
H1343_RS14710	COG1766	The M ring may be actively involved in energy transduction
H1343_RS14715	COG1338	Plays a role in the flagellum-specific transport system
H1343_RS14725	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H1343_RS14735	COG1706	bacterial-type flagellum-dependent cell motility
H1343_RS14740	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
H1343_RS14745	COG4786	Flagellar basal body rod
H1343_RS14750	COG1677	Flagellar hook-basal body complex protein FliE
H1343_RS14755	COG1558	bacterial-type flagellum-dependent cell motility
H1343_RS14760	COG1815	bacterial-type flagellum-dependent cell motility
H1343_RS14770	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H1343_RS14775	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H1343_RS14780	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H1343_RS14795	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H1343_RS14800	COG4786	Flagellar basal body rod
H1343_RS14805	COG1157	protein secretion by the type III secretion system
H1343_RS14810	COG5001	Diguanylate cyclase
H1343_RS14820	COG1218	3'(2'),5'-bisphosphate nucleotidase
H1343_RS14825	COG1320	monovalent cation:proton antiporter activity
H1343_RS14830	COG2212	antiporter activity
H1343_RS14835	COG1863	multisubunit Na H antiporter MnhE subunit
H1343_RS14840	COG0651	ATP synthesis coupled electron transport
H1343_RS14845	COG1006	Multisubunit Na H antiporter MnhC subunit
H1343_RS14850	COG2111	Na H antiporter
H1343_RS14855	COG2111	Na H antiporter
H1343_RS14855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1343_RS14880	COG0583	DNA-binding transcription factor activity
H1343_RS14885	COG2010	Cytochrome c
H1343_RS14890	COG3909	cytochrome
H1343_RS14895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H1343_RS14900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1343_RS14905	COG1376	ErfK ybiS ycfS ynhG family protein
H1343_RS14915	COG0433	COG0433 Predicted ATPase
H1343_RS14925	COG3300	MHYT domain
H1343_RS14925	COG5001	Diguanylate cyclase
H1343_RS14940	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H1343_RS14950	COG1830	Aldolase
H1343_RS14960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H1343_RS15000	COG0693	protein deglycase activity
H1343_RS15015	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H1343_RS15020	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
H1343_RS15030	COG0471	metal ion transport
H1343_RS15040	COG0583	DNA-binding transcription factor activity
H1343_RS15050	COG3153	acetyltransferase
H1343_RS15060	COG0523	cobalamin synthesis protein
H1343_RS15065	COG1609	Transcriptional regulator
H1343_RS15070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H1343_RS15090	COG0800	Aldolase
H1343_RS15105	COG5632	N-Acetylmuramoyl-L-alanine amidase
H1343_RS15105	COG3409	Peptidoglycan-binding domain 1 protein
H1343_RS15115	COG3119	arylsulfatase activity
H1343_RS15135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H1343_RS15190	COG0739	heme binding
H1343_RS15200	COG1376	ErfK ybiS ycfS ynhG family protein
H1343_RS15215	COG0542	response to heat
H1343_RS15225	COG2890	protein-(glutamine-N5) methyltransferase activity
H1343_RS15230	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H1343_RS15235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H1343_RS15240	COG0527	aspartate kinase activity
H1343_RS15245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H1343_RS15255	COG0783	Belongs to the Dps family
H1343_RS15275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1343_RS15290	COG2226	methyltransferase
H1343_RS15300	COG0494	nUDIX hydrolase
H1343_RS15315	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H1343_RS15320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1343_RS15325	COG0653	protein targeting
H1343_RS15345	COG1971	Probably functions as a manganese efflux pump
H1343_RS15355	COG0825	malonyl-CoA metabolic process
H1343_RS15370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H1343_RS15375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H1343_RS15415	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H1343_RS15420	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H1343_RS15435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1343_RS15455	COG2813	Specifically methylates the guanine in position
H1343_RS15455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1343_RS15460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1343_RS15475	COG0287	Prephenate dehydrogenase
H1343_RS15490	COG0318	PFAM AMP-dependent synthetase and ligase
H1343_RS15490	COG0204	Acyl-transferase
H1343_RS15505	COG2884	Cell division ATP-binding protein ftsE
H1343_RS15525	COG4106	trans-aconitate 2-methyltransferase activity
H1343_RS15545	COG0165	Argininosuccinate lyase
H1343_RS15550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H1343_RS15560	COG5001	Diguanylate cyclase
H1343_RS15560	COG3300	MHYT domain
H1343_RS15575	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1343_RS15580	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H1343_RS15585	COG2086	electron transfer activity
H1343_RS15590	COG2096	Adenosyltransferase
H1343_RS15600	COG0679	Auxin Efflux Carrier
H1343_RS15605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1343_RS15625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H1343_RS15635	COG2847	Copper chaperone PCu(A)C
H1343_RS15640	COG1999	signal sequence binding
H1343_RS15670	COG1959	2 iron, 2 sulfur cluster binding
H1343_RS15680	COG1028	Short-chain dehydrogenase reductase Sdr
H1343_RS15685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1343_RS15700	COG0765	amino acid transport
H1343_RS15705	COG0765	amino acid transport
H1343_RS15730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1343_RS15735	COG1396	sequence-specific DNA binding
H1343_RS15735	COG1917	Cupin 2, conserved barrel domain protein
H1343_RS15745	COG0601	transmembrane transport
H1343_RS15750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1343_RS15760	COG0402	S-adenosylhomocysteine deaminase activity
H1343_RS15765	COG0444	Belongs to the ABC transporter superfamily
H1343_RS15770	COG4608	Belongs to the ABC transporter superfamily
H1343_RS15775	COG0028	Belongs to the TPP enzyme family
H1343_RS15780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H1343_RS15795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H1343_RS15795	COG0425	Belongs to the sulfur carrier protein TusA family
H1343_RS15800	COG0523	cobalamin synthesis protein
H1343_RS15810	COG1473	amidohydrolase
H1343_RS15815	COG1396	sequence-specific DNA binding
H1343_RS15820	COG0784	Response regulator, receiver
H1343_RS15830	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
H1343_RS15835	COG5001	Diguanylate cyclase
H1343_RS15845	COG2084	Dehydrogenase
H1343_RS15860	COG2186	Transcriptional regulator
H1343_RS15880	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1343_RS15885	COG1177	transmembrane transport
H1343_RS15915	COG0673	inositol 2-dehydrogenase activity
H1343_RS15945	COG0784	Response regulator, receiver
H1343_RS15945	COG4191	Histidine kinase
H1343_RS15950	COG3920	Histidine kinase
H1343_RS15950	COG2202	Pas domain
H1343_RS15960	COG1295	ribonuclease BN
H1343_RS15975	COG3546	catalase activity
H1343_RS15990	COG2813	Specifically methylates the guanine in position
H1343_RS15995	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H1343_RS16005	COG4948	Mandelate Racemase Muconate Lactonizing
H1343_RS16025	COG0579	oxidoreductase
H1343_RS16040	COG0583	DNA-binding transcription factor activity
H1343_RS16070	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H1343_RS16090	COG1028	Short-chain dehydrogenase reductase Sdr
H1343_RS16095	COG0183	Belongs to the thiolase family
H1343_RS16100	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H1343_RS16105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H1343_RS16110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H1343_RS16115	COG0142	geranyltranstransferase activity
H1343_RS16125	COG0385	Bile acid
H1343_RS16150	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H1343_RS16160	COG1640	4-alpha-glucanotransferase
H1343_RS16165	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H1343_RS16190	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H1343_RS16200	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H1343_RS16205	COG4266	Belongs to the allantoicase family
H1343_RS16215	COG2351	hydroxyisourate hydrolase activity
H1343_RS16225	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1343_RS16235	COG3845	ABC transporter
H1343_RS16240	COG4603	Belongs to the binding-protein-dependent transport system permease family
H1343_RS16245	COG1079	Belongs to the binding-protein-dependent transport system permease family
H1343_RS16260	COG0402	S-adenosylhomocysteine deaminase activity
H1343_RS16265	COG0366	Alpha amylase catalytic
H1343_RS16280	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H1343_RS16285	COG0830	nickel cation binding
H1343_RS16290	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H1343_RS16305	COG0804	urea catabolic process
H1343_RS16320	COG0832	Belongs to the urease beta subunit family
H1343_RS16330	COG0831	urea catabolic process
H1343_RS16335	COG0829	nickel cation binding
H1343_RS16385	COG2223	nitrite transmembrane transporter activity
H1343_RS16390	COG1132	(ABC) transporter
H1343_RS16430	COG1069	ribulokinase activity
H1343_RS16435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1343_RS16445	COG2031	fatty acid transporter
H1343_RS16450	COG4604	ABC transporter, ATP-binding protein
H1343_RS16455	COG4605	iron ion homeostasis
H1343_RS16460	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1343_RS16480	COG1840	ABC-type Fe3 transport system, periplasmic component
H1343_RS16500	COG1696	Membrane protein involved in D-alanine export
H1343_RS16510	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H1343_RS16520	COG2943	transferase activity, transferring hexosyl groups
H1343_RS16530	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H1343_RS16550	COG0588	phosphoglycerate mutase activity
H1343_RS16560	COG1132	(ABC) transporter
H1343_RS16565	COG0837	glucose binding
H1343_RS16570	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
H1343_RS16575	COG0072	phenylalanine-tRNA ligase activity
H1343_RS16575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1343_RS16595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H1343_RS16600	COG1733	regulation of RNA biosynthetic process
H1343_RS16605	COG1028	Short-chain dehydrogenase reductase Sdr
H1343_RS16610	COG0251	oxidation-reduction process
H1343_RS16615	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H1343_RS16625	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H1343_RS16635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H1343_RS16650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H1343_RS16660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1343_RS16670	COG0606	chelatase, subunit chli
H1343_RS16680	COG0189	ligase activity
H1343_RS16685	COG3158	transport of potassium into the cell
H1343_RS16690	COG0792	nuclease activity
H1343_RS16695	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H1343_RS16700	COG1742	UPF0060 membrane protein
H1343_RS16705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H1343_RS16710	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H1343_RS16715	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H1343_RS16725	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H1343_RS16730	COG1028	Short-chain dehydrogenase reductase Sdr
H1343_RS16740	COG1252	NADH dehydrogenase
H1343_RS16750	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H1343_RS16755	COG0424	maF-like protein
H1343_RS16760	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H1343_RS16765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H1343_RS16780	COG1595	DNA-templated transcription, initiation
H1343_RS16795	COG0842	Transport permease protein
H1343_RS16800	COG1131	(ABC) transporter
H1343_RS16820	COG0668	transmembrane transport
H1343_RS16830	COG0756	dUTP diphosphatase activity
H1343_RS16835	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H1343_RS16850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H1343_RS16860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H1343_RS16865	COG0268	Binds directly to 16S ribosomal RNA
H1343_RS16960	COG0077	Prephenate dehydratase
H1343_RS16960	COG1605	Chorismate mutase
H1343_RS16990	COG0463	Glycosyl transferase, family 2