locus-tag	class	description
J7654_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J7654_RS00035	COG0735	belongs to the Fur family
J7654_RS00045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J7654_RS00055	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J7654_RS00060	COG0667	Aldo Keto reductase
J7654_RS00070	COG1185	polyribonucleotide nucleotidyltransferase activity
J7654_RS00075	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J7654_RS00090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J7654_RS00095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J7654_RS00095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J7654_RS00110	COG0779	Required for maturation of 30S ribosomal subunits
J7654_RS00115	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J7654_RS00120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J7654_RS00125	COG1396	sequence-specific DNA binding
J7654_RS00135	COG1253	flavin adenine dinucleotide binding
J7654_RS00140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J7654_RS00150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J7654_RS00165	COG1214	PFAM Peptidase M22, glycoprotease
J7654_RS00170	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
J7654_RS00175	COG0778	Nitroreductase
J7654_RS00185	COG0180	Tryptophanyl-tRNA synthetase
J7654_RS00190	COG0728	peptidoglycan biosynthetic process
J7654_RS00195	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
J7654_RS00200	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS00205	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J7654_RS00220	COG0604	alcohol dehydrogenase
J7654_RS00225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J7654_RS00230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J7654_RS00250	COG0616	signal peptide processing
J7654_RS00265	COG1137	ATPase activity
J7654_RS00270	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
J7654_RS00275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
J7654_RS00280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J7654_RS00290	COG0071	Belongs to the small heat shock protein (HSP20) family
J7654_RS00295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J7654_RS00300	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
J7654_RS00310	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
J7654_RS00320	COG0745	RESPONSE REGULATOR receiver
J7654_RS00325	COG0642	Histidine kinase
J7654_RS00335	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
J7654_RS00335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J7654_RS00345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J7654_RS00350	COG2205	protein histidine kinase activity
J7654_RS00355	COG3178	'Phosphotransferase
J7654_RS00360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J7654_RS00380	COG0285	dihydrofolate synthase activity
J7654_RS00390	COG0159	tryptophan synthase activity
J7654_RS00400	COG0133	tryptophan synthase activity
J7654_RS00405	COG0135	phosphoribosylanthranilate isomerase activity
J7654_RS00430	COG0284	orotidine-5'-phosphate decarboxylase activity
J7654_RS00435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J7654_RS00435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J7654_RS00440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J7654_RS00445	COG1393	Belongs to the ArsC family
J7654_RS00470	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J7654_RS00490	COG0443	Heat shock 70 kDa protein
J7654_RS00500	COG0484	heat shock protein binding
J7654_RS00505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J7654_RS00510	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J7654_RS00520	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS00525	COG1643	Atp-dependent helicase
J7654_RS00535	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
J7654_RS00550	COG1376	ErfK ybiS ycfS ynhG family protein
J7654_RS00555	COG0471	metal ion transport
J7654_RS00575	COG0737	Belongs to the 5'-nucleotidase family
J7654_RS00580	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J7654_RS00590	COG0438	transferase activity, transferring glycosyl groups
J7654_RS00600	COG0848	biopolymer transport protein
J7654_RS00605	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
J7654_RS00620	COG2011	ABC-type metal ion transport system permease component
J7654_RS00625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J7654_RS00650	COG1968	undecaprenyl-diphosphatase activity
J7654_RS00660	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J7654_RS00680	COG3409	Peptidoglycan-binding domain 1 protein
J7654_RS00680	COG3773	Cell wall hydrolase
J7654_RS00690	COG0583	DNA-binding transcription factor activity
J7654_RS00695	COG1132	(ABC) transporter
J7654_RS00700	COG2329	Antibiotic biosynthesis monooxygenase
J7654_RS00705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J7654_RS00710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J7654_RS00715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J7654_RS00720	COG1116	anion transmembrane transporter activity
J7654_RS00730	COG1280	lysine exporter protein (LysE YggA)
J7654_RS00740	COG1309	transcriptional regulator
J7654_RS00750	COG0493	'glutamate synthase
J7654_RS00750	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
J7654_RS00765	COG4221	oxidoreductase activity
J7654_RS00770	COG4166	transmembrane transport
J7654_RS00775	COG0601	transmembrane transport
J7654_RS00780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS00785	COG4172	Belongs to the ABC transporter superfamily
J7654_RS00790	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J7654_RS00795	COG4208	sulfate ABC transporter
J7654_RS00815	COG1959	2 iron, 2 sulfur cluster binding
J7654_RS00820	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
J7654_RS00825	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
J7654_RS00830	COG4208	sulfate ABC transporter
J7654_RS00835	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J7654_RS00850	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J7654_RS00855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J7654_RS00860	COG0539	negative regulation of cytoplasmic translation
J7654_RS00890	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
J7654_RS00895	COG3842	ATPase activity
J7654_RS00900	COG1176	ABC-type spermidine putrescine transport system, permease component I
J7654_RS00905	COG1177	transmembrane transport
J7654_RS00915	COG0402	S-adenosylhomocysteine deaminase activity
J7654_RS00930	COG1176	ABC-type spermidine putrescine transport system, permease component I
J7654_RS00935	COG3842	ATPase activity
J7654_RS00965	COG4993	Dehydrogenase
J7654_RS00970	COG4608	Belongs to the ABC transporter superfamily
J7654_RS00985	COG0747	negative chemotaxis
J7654_RS01010	COG0579	oxidoreductase
J7654_RS01015	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J7654_RS01030	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
J7654_RS01035	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
J7654_RS01040	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
J7654_RS01050	COG1477	protein flavinylation
J7654_RS01060	COG0517	IMP dehydrogenase activity
J7654_RS01060	COG0617	tRNA 3'-terminal CCA addition
J7654_RS01060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
J7654_RS01080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J7654_RS01090	COG0840	transmembrane signaling receptor activity
J7654_RS01100	COG0745	RESPONSE REGULATOR receiver
J7654_RS01105	COG2198	Histidine kinase
J7654_RS01105	COG0643	Histidine kinase
J7654_RS01110	COG0835	chemotaxis
J7654_RS01135	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
J7654_RS01145	COG2205	protein histidine kinase activity
J7654_RS01155	COG4565	transcriptional regulatory protein
J7654_RS01165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J7654_RS01205	COG0443	Heat shock 70 kDa protein
J7654_RS01220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J7654_RS01230	COG0483	inositol monophosphate 1-phosphatase activity
J7654_RS01235	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
J7654_RS01235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J7654_RS01245	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
J7654_RS01250	COG2894	cell division
J7654_RS01255	COG0850	regulation of cytokinetic process
J7654_RS01275	COG1116	anion transmembrane transporter activity
J7654_RS01295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J7654_RS01300	COG0235	Class ii aldolase
J7654_RS01305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J7654_RS01310	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
J7654_RS01320	COG0765	amino acid transport
J7654_RS01330	COG4221	oxidoreductase activity
J7654_RS01350	COG4172	Belongs to the ABC transporter superfamily
J7654_RS01365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS01375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J7654_RS01390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J7654_RS01395	COG1120	ATPase activity
J7654_RS01400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J7654_RS01425	COG0601	transmembrane transport
J7654_RS01430	COG0583	DNA-binding transcription factor activity
J7654_RS01450	COG4558	Periplasmic binding protein
J7654_RS01455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J7654_RS01460	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
J7654_RS01470	COG3706	GGDEF domain
J7654_RS01475	COG1309	transcriptional regulator
J7654_RS01490	COG0500	methyltransferase
J7654_RS01515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J7654_RS01520	COG3639	organic phosphonate transmembrane transporter activity
J7654_RS01525	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
J7654_RS01530	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
J7654_RS01555	COG1215	transferase activity, transferring glycosyl groups
J7654_RS01575	COG1921	L-seryl-tRNASec selenium transferase activity
J7654_RS01585	COG2864	formate dehydrogenase
J7654_RS01590	COG0437	4 iron, 4 sulfur cluster binding
J7654_RS01600	COG0709	Synthesizes selenophosphate from selenide and ATP
J7654_RS01615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J7654_RS01620	COG1215	transferase activity, transferring glycosyl groups
J7654_RS01630	COG2246	polysaccharide biosynthetic process
J7654_RS01635	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
J7654_RS01655	COG1091	dTDP-4-dehydrorhamnose reductase activity
J7654_RS01660	COG1088	dTDP-glucose 4,6-dehydratase activity
J7654_RS01665	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
J7654_RS01675	COG1216	Glycosyl transferase, family 2
J7654_RS01680	COG1596	polysaccharide export
J7654_RS01695	COG2273	Hydrolase Family 16
J7654_RS01710	COG1216	Glycosyl transferase, family 2
J7654_RS01715	COG0438	transferase activity, transferring glycosyl groups
J7654_RS01730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J7654_RS01755	COG3214	Protein conserved in bacteria
J7654_RS01760	COG0477	Major facilitator Superfamily
J7654_RS01765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J7654_RS01770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J7654_RS01775	COG1845	cytochrome c oxidase, subunit III
J7654_RS01780	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
J7654_RS01800	COG1999	signal sequence binding
J7654_RS01820	COG0436	Aminotransferase
J7654_RS01825	COG1012	belongs to the aldehyde dehydrogenase family
J7654_RS01835	COG5383	Protein conserved in bacteria
J7654_RS01850	COG1012	belongs to the aldehyde dehydrogenase family
J7654_RS01865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J7654_RS01865	COG1522	sequence-specific DNA binding
J7654_RS01870	COG2313	pseudouridylate synthase activity
J7654_RS01875	COG0514	ATP-dependent DNA helicase (RecQ)
J7654_RS01890	COG2172	sigma factor antagonist activity
J7654_RS01895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J7654_RS01900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J7654_RS01900	COG1017	nitric oxide dioxygenase activity
J7654_RS01905	COG2423	ornithine cyclodeaminase activity
J7654_RS01910	COG1476	TRANSCRIPTIONal
J7654_RS01950	COG2022	thiamine diphosphate biosynthetic process
J7654_RS01965	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
J7654_RS01970	COG4774	siderophore transport
J7654_RS01975	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
J7654_RS01985	COG1120	ATPase activity
J7654_RS01995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J7654_RS02000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J7654_RS02005	COG1116	anion transmembrane transporter activity
J7654_RS02010	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
J7654_RS02020	COG2354	Protein conserved in bacteria
J7654_RS02060	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J7654_RS02075	COG1250	3-hydroxyacyl-CoA dehydrogenase
J7654_RS02080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J7654_RS02085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J7654_RS02090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J7654_RS02120	COG3181	Tripartite tricarboxylate transporter family receptor
J7654_RS02125	COG4948	Mandelate Racemase Muconate Lactonizing
J7654_RS02135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J7654_RS02145	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS02155	COG4638	Rieske (2fe-2S)
J7654_RS02165	COG0154	amidase activity
J7654_RS02200	COG2202	Pas domain
J7654_RS02200	COG3920	Histidine kinase
J7654_RS02205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J7654_RS02215	COG1116	anion transmembrane transporter activity
J7654_RS02230	COG0402	S-adenosylhomocysteine deaminase activity
J7654_RS02235	COG4166	transmembrane transport
J7654_RS02240	COG0601	transmembrane transport
J7654_RS02245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS02250	COG4608	Belongs to the ABC transporter superfamily
J7654_RS02260	COG0154	amidase activity
J7654_RS02265	COG0444	Belongs to the ABC transporter superfamily
J7654_RS02280	COG4589	Belongs to the CDS family
J7654_RS02295	COG5001	Diguanylate cyclase
J7654_RS02300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J7654_RS02305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J7654_RS02310	COG4957	zinc ion binding
J7654_RS02315	COG0406	alpha-ribazole phosphatase activity
J7654_RS02320	COG3842	ATPase activity
J7654_RS02340	COG1473	amidohydrolase
J7654_RS02355	COG0747	negative chemotaxis
J7654_RS02360	COG0601	transmembrane transport
J7654_RS02365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS02370	COG0444	Belongs to the ABC transporter superfamily
J7654_RS02380	COG4302	ethanolamine ammonia-lyase activity
J7654_RS02385	COG4303	Ethanolamine ammonia lyase large subunit
J7654_RS02390	COG1177	transmembrane transport
J7654_RS02395	COG1176	ABC-type spermidine putrescine transport system, permease component I
J7654_RS02400	COG3842	ATPase activity
J7654_RS02410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J7654_RS02420	COG0583	DNA-binding transcription factor activity
J7654_RS02440	COG1349	DNA-binding transcription factor activity
J7654_RS02445	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
J7654_RS02455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J7654_RS02460	COG0579	oxidoreductase
J7654_RS02475	COG1176	ABC-type spermidine putrescine transport system, permease component I
J7654_RS02485	COG3842	ATPase activity
J7654_RS02495	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
J7654_RS02510	COG1042	CoA-binding domain protein
J7654_RS02510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J7654_RS02510	COG0045	succinate-CoA ligase (ADP-forming) activity
J7654_RS02515	COG3706	GGDEF domain
J7654_RS02530	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J7654_RS02560	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J7654_RS02565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J7654_RS02585	COG2264	protein methyltransferase activity
J7654_RS02590	COG0243	molybdopterin cofactor binding
J7654_RS02600	COG0745	RESPONSE REGULATOR receiver
J7654_RS02605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J7654_RS02615	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
J7654_RS02620	COG1674	ftsk spoiiie
J7654_RS02630	COG0004	ammonium transporteR
J7654_RS02635	COG0347	Belongs to the P(II) protein family
J7654_RS02640	COG0004	ammonium transporteR
J7654_RS02645	COG0347	Belongs to the P(II) protein family
J7654_RS02650	COG1946	Acyl-CoA thioesterase
J7654_RS02655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J7654_RS02665	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J7654_RS02675	COG0175	sulfate reduction
J7654_RS02680	COG0175	sulfate reduction
J7654_RS02685	COG2895	sulfate adenylyltransferase (ATP) activity
J7654_RS02690	COG2835	tetraacyldisaccharide 4'-kinase activity
J7654_RS02695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
J7654_RS02715	COG2080	2 iron, 2 sulfur cluster binding
J7654_RS02720	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J7654_RS02760	COG0765	amino acid transport
J7654_RS02765	COG0765	amino acid transport
J7654_RS02770	COG1126	abc transporter atp-binding protein
J7654_RS02775	COG0010	Belongs to the arginase family
J7654_RS02835	COG0784	Response regulator, receiver
J7654_RS02835	COG2198	Histidine kinase
J7654_RS02835	COG2205	protein histidine kinase activity
J7654_RS02870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J7654_RS02875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J7654_RS02880	COG1121	(ABC) transporter
J7654_RS02900	COG4774	siderophore transport
J7654_RS02925	COG0523	cobalamin synthesis protein
J7654_RS02940	COG3842	ATPase activity
J7654_RS02950	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS02960	COG4208	sulfate ABC transporter
J7654_RS02965	COG1176	ABC-type spermidine putrescine transport system, permease component I
J7654_RS02980	COG1984	allophanate hydrolase subunit 2
J7654_RS02995	COG0511	ligase activity, forming carbon-carbon bonds
J7654_RS03005	COG0583	DNA-binding transcription factor activity
J7654_RS03015	COG1054	Belongs to the UPF0176 family
J7654_RS03020	COG3698	Phosphodiester glycosidase
J7654_RS03025	COG1902	pentaerythritol trinitrate reductase activity
J7654_RS03045	COG0179	Fumarylacetoacetate (FAA) hydrolase
J7654_RS03060	COG0747	negative chemotaxis
J7654_RS03065	COG4948	Mandelate Racemase Muconate Lactonizing
J7654_RS03075	COG1454	alcohol dehydrogenase
J7654_RS03080	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
J7654_RS03095	COG0435	Glutathione S-transferase
J7654_RS03100	COG2514	catechol 2,3-dioxygenase activity
J7654_RS03120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J7654_RS03130	COG1126	abc transporter atp-binding protein
J7654_RS03135	COG0765	amino acid transport
J7654_RS03140	COG0765	amino acid transport
J7654_RS03145	COG2084	Dehydrogenase
J7654_RS03150	COG0698	ribose 5-phosphate isomerase
J7654_RS03160	COG1309	transcriptional regulator
J7654_RS03190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J7654_RS03200	COG3938	Belongs to the proline racemase family
J7654_RS03220	COG3842	ATPase activity
J7654_RS03225	COG1177	transmembrane transport
J7654_RS03230	COG1228	amidohydrolase
J7654_RS03235	COG1228	amidohydrolase
J7654_RS03250	COG1802	Transcriptional regulator
J7654_RS03270	COG0747	negative chemotaxis
J7654_RS03275	COG0601	transmembrane transport
J7654_RS03280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS03290	COG4608	Belongs to the ABC transporter superfamily
J7654_RS03305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J7654_RS03310	COG2188	Transcriptional regulator
J7654_RS03330	COG2079	MmgE PrpD family protein
J7654_RS03335	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS03340	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS03350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J7654_RS03365	COG1802	Transcriptional regulator
J7654_RS03375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J7654_RS03385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J7654_RS03390	COG1957	nucleoside hydrolase
J7654_RS03410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J7654_RS03415	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS03420	COG3842	ATPase activity
J7654_RS03430	COG1175	transmembrane transport
J7654_RS03435	COG0395	ABC-type sugar transport system, permease component
J7654_RS03440	COG0235	Class ii aldolase
J7654_RS03445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J7654_RS03450	COG1737	Transcriptional regulator
J7654_RS03460	COG3842	ATPase activity
J7654_RS03475	COG0405	Gamma-glutamyltransferase
J7654_RS03485	COG0154	amidase activity
J7654_RS03490	COG0747	negative chemotaxis
J7654_RS03495	COG1082	Xylose isomerase domain protein TIM barrel
J7654_RS03515	COG1247	-acetyltransferase
J7654_RS03540	COG0165	Argininosuccinate lyase
J7654_RS03550	COG0251	oxidation-reduction process
J7654_RS03560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J7654_RS03565	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS03590	COG1132	(ABC) transporter
J7654_RS03600	COG0367	asparagine synthase
J7654_RS03625	COG1215	transferase activity, transferring glycosyl groups
J7654_RS03635	COG2273	Hydrolase Family 16
J7654_RS03640	COG0438	transferase activity, transferring glycosyl groups
J7654_RS03645	COG1215	transferase activity, transferring glycosyl groups
J7654_RS03650	COG1215	transferase activity, transferring glycosyl groups
J7654_RS03655	COG1215	transferase activity, transferring glycosyl groups
J7654_RS03660	COG3206	protein involved in exopolysaccharide biosynthesis
J7654_RS03660	COG0489	protein tyrosine kinase activity
J7654_RS03665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J7654_RS03675	COG1596	polysaccharide export
J7654_RS03680	COG3307	-O-antigen
J7654_RS03730	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
J7654_RS03735	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
J7654_RS03740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
J7654_RS03745	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS03760	COG1024	Enoyl-CoA hydratase
J7654_RS03765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J7654_RS03765	COG1522	sequence-specific DNA binding
J7654_RS03780	COG3842	ATPase activity
J7654_RS03785	COG1176	ABC-type spermidine putrescine transport system, permease component I
J7654_RS03790	COG1177	transmembrane transport
J7654_RS03795	COG0604	alcohol dehydrogenase
J7654_RS03805	COG0277	FAD linked oxidase domain protein
J7654_RS03815	COG1957	nucleoside hydrolase
J7654_RS03825	COG0747	negative chemotaxis
J7654_RS03830	COG0601	transmembrane transport
J7654_RS03835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS03840	COG0444	Belongs to the ABC transporter superfamily
J7654_RS03845	COG4608	Belongs to the ABC transporter superfamily
J7654_RS03850	COG0405	Gamma-glutamyltransferase
J7654_RS03895	COG0747	negative chemotaxis
J7654_RS03910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J7654_RS03940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J7654_RS03945	COG2186	Transcriptional regulator
J7654_RS03955	COG4948	Mandelate Racemase Muconate Lactonizing
J7654_RS03960	COG3618	amidohydrolase
J7654_RS03980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS03985	COG0601	transmembrane transport
J7654_RS03990	COG0747	negative chemotaxis
J7654_RS04015	COG0745	RESPONSE REGULATOR receiver
J7654_RS04030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J7654_RS04035	COG1012	belongs to the aldehyde dehydrogenase family
J7654_RS04040	COG1522	sequence-specific DNA binding
J7654_RS04045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J7654_RS04050	COG1126	abc transporter atp-binding protein
J7654_RS04060	COG0765	amino acid transport
J7654_RS04065	COG0765	amino acid transport
J7654_RS04075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J7654_RS04080	COG2423	ornithine cyclodeaminase activity
J7654_RS04085	COG0006	proline dipeptidase activity
J7654_RS04090	COG3608	succinylglutamate desuccinylase aspartoacylase
J7654_RS04095	COG1609	Transcriptional regulator
J7654_RS04105	COG1129	ABC transporter
J7654_RS04110	COG1172	Belongs to the binding-protein-dependent transport system permease family
J7654_RS04120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
J7654_RS04125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J7654_RS04130	COG1120	ATPase activity
J7654_RS04135	COG3585	molybdate ion transport
J7654_RS04140	COG1720	tRNA m6t6A37 methyltransferase activity
J7654_RS04160	COG1172	Belongs to the binding-protein-dependent transport system permease family
J7654_RS04165	COG1172	Belongs to the binding-protein-dependent transport system permease family
J7654_RS04170	COG1129	ABC transporter
J7654_RS04185	COG1072	(Pantothenic acid kinase))
J7654_RS04210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J7654_RS04225	COG1984	allophanate hydrolase subunit 2
J7654_RS04250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS04255	COG0601	transmembrane transport
J7654_RS04260	COG0747	negative chemotaxis
J7654_RS04265	COG0006	proline dipeptidase activity
J7654_RS04270	COG2186	Transcriptional regulator
J7654_RS04275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J7654_RS04280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J7654_RS04285	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
J7654_RS04290	COG0519	Catalyzes the synthesis of GMP from XMP
J7654_RS04305	COG0747	negative chemotaxis
J7654_RS04310	COG4608	Belongs to the ABC transporter superfamily
J7654_RS04320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS04325	COG0601	transmembrane transport
J7654_RS04335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J7654_RS04350	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
J7654_RS04360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J7654_RS04365	COG1959	2 iron, 2 sulfur cluster binding
J7654_RS04380	COG4774	siderophore transport
J7654_RS04400	COG4977	sequence-specific DNA binding
J7654_RS04405	COG0789	Transcriptional regulator
J7654_RS04415	COG1785	Belongs to the alkaline phosphatase family
J7654_RS04425	COG2267	carboxylic ester hydrolase activity
J7654_RS04435	COG3485	protocatechuate 3,4-dioxygenase
J7654_RS04455	COG1320	monovalent cation:proton antiporter activity
J7654_RS04465	COG1863	multisubunit Na H antiporter MnhE subunit
J7654_RS04470	COG0651	ATP synthesis coupled electron transport
J7654_RS04475	COG1006	Multisubunit Na H antiporter MnhC subunit
J7654_RS04480	COG2111	Na H antiporter
J7654_RS04485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J7654_RS04485	COG2111	Na H antiporter
J7654_RS04490	COG0583	DNA-binding transcription factor activity
J7654_RS04495	COG0402	S-adenosylhomocysteine deaminase activity
J7654_RS04505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS04510	COG0601	transmembrane transport
J7654_RS04515	COG0747	negative chemotaxis
J7654_RS04555	COG3920	Histidine kinase
J7654_RS04560	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J7654_RS04570	COG1764	response to oxidative stress
J7654_RS04585	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J7654_RS04590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J7654_RS04610	COG0508	dehydrogenase complex catalyzes the overall conversion of
J7654_RS04620	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J7654_RS04625	COG0045	succinate-CoA ligase (ADP-forming) activity
J7654_RS04630	COG0039	L-malate dehydrogenase activity
J7654_RS04635	COG3706	GGDEF domain
J7654_RS04640	COG2845	Protein of unknown function (DUF459)
J7654_RS04645	COG0288	reversible hydration of carbon dioxide
J7654_RS04660	COG2902	Dehydrogenase
J7654_RS04670	COG0138	bifunctional purine biosynthesis protein purh
J7654_RS04690	COG0501	Belongs to the peptidase M48B family
J7654_RS04705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J7654_RS04710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J7654_RS04750	COG0357	Ribosomal RNA small subunit methyltransferase G
J7654_RS04755	COG0445	tRNA wobble uridine modification
J7654_RS04760	COG0456	acetyltransferase
J7654_RS04770	COG1331	Highly conserved protein containing a thioredoxin domain
J7654_RS04775	COG0442	prolyl-tRNA aminoacylation
J7654_RS04780	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J7654_RS04790	COG3265	gluconokinase activity
J7654_RS04800	COG1981	membrane
J7654_RS04805	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J7654_RS04810	COG0424	maF-like protein
J7654_RS04825	COG0237	dephospho-CoA kinase activity
J7654_RS04830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J7654_RS04835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
J7654_RS04840	COG3030	protein affecting phage T7 exclusion by the F plasmid
J7654_RS04850	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
J7654_RS04860	COG1396	sequence-specific DNA binding
J7654_RS04860	COG3800	Transcriptional regulator
J7654_RS04875	COG2133	pyrroloquinoline quinone binding
J7654_RS04880	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
J7654_RS04885	COG2197	response regulator
J7654_RS04900	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
J7654_RS04905	COG1072	(Pantothenic acid kinase))
J7654_RS04910	COG0140	phosphoribosyl-ATP diphosphatase activity
J7654_RS04915	COG0107	imidazoleglycerol-phosphate synthase activity
J7654_RS04920	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J7654_RS04925	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J7654_RS04935	COG0131	Imidazoleglycerol-phosphate dehydratase
J7654_RS04940	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
J7654_RS04970	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
J7654_RS04975	COG3845	ABC transporter
J7654_RS04980	COG4721	ABC-type cobalt transport system, permease component
J7654_RS04990	COG0405	Gamma-glutamyltransferase
J7654_RS04995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS05005	COG0747	negative chemotaxis
J7654_RS05010	COG0747	negative chemotaxis
J7654_RS05020	COG4608	Belongs to the ABC transporter superfamily
J7654_RS05025	COG0444	Belongs to the ABC transporter superfamily
J7654_RS05050	COG1294	oxidase, subunit
J7654_RS05055	COG1271	oxidase subunit
J7654_RS05060	COG4988	ABC transporter
J7654_RS05065	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J7654_RS05090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J7654_RS05095	COG4191	Histidine kinase
J7654_RS05100	COG4566	intracellular signal transduction
J7654_RS05105	COG4566	intracellular signal transduction
J7654_RS05110	COG3300	MHYT domain
J7654_RS05110	COG5001	Diguanylate cyclase
J7654_RS05120	COG1126	abc transporter atp-binding protein
J7654_RS05125	COG0765	amino acid transport
J7654_RS05130	COG0765	amino acid transport
J7654_RS05135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J7654_RS05140	COG2186	Transcriptional regulator
J7654_RS05145	COG3011	Protein conserved in bacteria
J7654_RS05150	COG2358	TRAP transporter, solute receptor (TAXI family
J7654_RS05170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J7654_RS05175	COG4172	Belongs to the ABC transporter superfamily
J7654_RS05185	COG0601	transmembrane transport
J7654_RS05205	COG0251	oxidation-reduction process
J7654_RS05215	COG1802	Transcriptional regulator
J7654_RS05225	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
J7654_RS05235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J7654_RS05245	COG0601	transmembrane transport
J7654_RS05250	COG0747	negative chemotaxis
J7654_RS05255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J7654_RS05270	COG0747	negative chemotaxis
J7654_RS05275	COG0583	DNA-binding transcription factor activity
J7654_RS05280	COG1473	amidohydrolase
J7654_RS05290	COG4172	Belongs to the ABC transporter superfamily
J7654_RS05295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS05300	COG0601	transmembrane transport
J7654_RS05305	COG0747	negative chemotaxis
J7654_RS05315	COG0583	DNA-binding transcription factor activity
J7654_RS05320	COG1942	4-Oxalocrotonate Tautomerase
J7654_RS05330	COG0673	inositol 2-dehydrogenase activity
J7654_RS05375	COG0583	DNA-binding transcription factor activity
J7654_RS05380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J7654_RS05390	COG3842	ATPase activity
J7654_RS05395	COG4149	molybdate abc transporter
J7654_RS05400	COG1177	transmembrane transport
J7654_RS05405	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J7654_RS05420	COG1349	DNA-binding transcription factor activity
J7654_RS05435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J7654_RS05445	COG4172	Belongs to the ABC transporter superfamily
J7654_RS05450	COG0601	transmembrane transport
J7654_RS05455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS05460	COG0747	negative chemotaxis
J7654_RS05490	COG2885	chlorophyll binding
J7654_RS05495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J7654_RS05500	COG0477	Major facilitator Superfamily
J7654_RS05505	COG0473	3-isopropylmalate dehydrogenase activity
J7654_RS05515	COG0066	3-isopropylmalate dehydratase activity
J7654_RS05550	COG0587	DNA-directed DNA polymerase activity
J7654_RS05555	COG2010	Cytochrome c
J7654_RS05555	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J7654_RS05560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J7654_RS05585	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
J7654_RS05590	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
J7654_RS05595	COG3047	cAMP biosynthetic process
J7654_RS05600	COG1187	pseudouridine synthase activity
J7654_RS05610	COG0318	PFAM AMP-dependent synthetase and ligase
J7654_RS05635	COG2814	Major facilitator Superfamily
J7654_RS05640	COG0640	Transcriptional regulator
J7654_RS05655	COG2814	Major facilitator Superfamily
J7654_RS05670	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS05680	COG0583	DNA-binding transcription factor activity
J7654_RS05685	COG0667	Aldo Keto reductase
J7654_RS05690	COG2814	Major facilitator Superfamily
J7654_RS05695	COG0583	DNA-binding transcription factor activity
J7654_RS05700	COG1063	alcohol dehydrogenase
J7654_RS05705	COG0789	Transcriptional regulator
J7654_RS05770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J7654_RS05775	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
J7654_RS05785	COG1176	ABC-type spermidine putrescine transport system, permease component I
J7654_RS05790	COG3842	ATPase activity
J7654_RS05800	COG4302	ethanolamine ammonia-lyase activity
J7654_RS05805	COG4303	Ethanolamine ammonia lyase large subunit
J7654_RS05810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J7654_RS05825	COG1902	pentaerythritol trinitrate reductase activity
J7654_RS05845	COG1476	TRANSCRIPTIONal
J7654_RS05850	COG3842	ATPase activity
J7654_RS05855	COG1176	ABC-type spermidine putrescine transport system, permease component I
J7654_RS05865	COG1175	transmembrane transport
J7654_RS05875	COG5001	Diguanylate cyclase
J7654_RS05875	COG5002	protein histidine kinase activity
J7654_RS05895	COG4221	oxidoreductase activity
J7654_RS05910	COG0625	glutathione transferase activity
J7654_RS05930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J7654_RS05940	COG0590	tRNA wobble adenosine to inosine editing
J7654_RS05945	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS05960	COG0179	Fumarylacetoacetate (FAA) hydrolase
J7654_RS05975	COG0745	RESPONSE REGULATOR receiver
J7654_RS06000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J7654_RS06000	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J7654_RS06005	COG0789	Transcriptional regulator
J7654_RS06010	COG0667	Aldo Keto reductase
J7654_RS06015	COG1012	belongs to the aldehyde dehydrogenase family
J7654_RS06020	COG0702	epimerase
J7654_RS06025	COG1733	regulation of RNA biosynthetic process
J7654_RS06035	COG1764	response to oxidative stress
J7654_RS06040	COG1309	transcriptional regulator
J7654_RS06050	COG3706	GGDEF domain
J7654_RS06055	COG1176	ABC-type spermidine putrescine transport system, permease component I
J7654_RS06065	COG0588	phosphoglycerate mutase activity
J7654_RS06075	COG3842	ATPase activity
J7654_RS06085	COG0625	glutathione transferase activity
J7654_RS06115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J7654_RS06125	COG0583	DNA-binding transcription factor activity
J7654_RS06135	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS06145	COG0667	Aldo Keto reductase
J7654_RS06150	COG3058	Necessary for formate dehydrogenase activity
J7654_RS06155	COG2864	formate dehydrogenase
J7654_RS06160	COG0437	4 iron, 4 sulfur cluster binding
J7654_RS06165	COG0243	molybdopterin cofactor binding
J7654_RS06165	COG3383	formate dehydrogenase (NAD+) activity
J7654_RS06170	COG1252	NADH dehydrogenase
J7654_RS06185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J7654_RS06190	COG0765	amino acid transport
J7654_RS06195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J7654_RS06205	COG1126	abc transporter atp-binding protein
J7654_RS06225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J7654_RS06230	COG1473	amidohydrolase
J7654_RS06240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J7654_RS06245	COG4172	Belongs to the ABC transporter superfamily
J7654_RS06250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS06265	COG1522	sequence-specific DNA binding
J7654_RS06270	COG1957	nucleoside hydrolase
J7654_RS06275	COG1609	Transcriptional regulator
J7654_RS06315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J7654_RS06330	COG0145	ligase activity
J7654_RS06360	COG1414	Transcriptional regulator
J7654_RS06365	COG4638	Rieske (2fe-2S)
J7654_RS06385	COG1129	ABC transporter
J7654_RS06400	COG0583	DNA-binding transcription factor activity
J7654_RS06405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J7654_RS06410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J7654_RS06415	COG4172	Belongs to the ABC transporter superfamily
J7654_RS06420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS06425	COG0601	transmembrane transport
J7654_RS06430	COG0747	negative chemotaxis
J7654_RS06445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J7654_RS06450	COG0251	oxidation-reduction process
J7654_RS06455	COG2814	Major facilitator Superfamily
J7654_RS06460	COG0431	NADPH-dependent FMN reductase
J7654_RS06470	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J7654_RS06480	COG0402	S-adenosylhomocysteine deaminase activity
J7654_RS06485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J7654_RS06495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J7654_RS06510	COG0583	DNA-binding transcription factor activity
J7654_RS06515	COG0165	Argininosuccinate lyase
J7654_RS06520	COG0765	amino acid transport
J7654_RS06530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J7654_RS06540	COG0402	S-adenosylhomocysteine deaminase activity
J7654_RS06550	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
J7654_RS06560	COG1960	acyl-CoA dehydrogenase activity
J7654_RS06585	COG0583	DNA-binding transcription factor activity
J7654_RS06590	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J7654_RS06590	COG2010	Cytochrome c
J7654_RS06595	COG2080	2 iron, 2 sulfur cluster binding
J7654_RS06600	COG1846	Transcriptional regulator
J7654_RS06605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J7654_RS06610	COG0596	Alpha beta hydrolase
J7654_RS06615	COG3473	Maleate cis-trans isomerase
J7654_RS06620	COG1335	isochorismatase
J7654_RS06625	COG2309	aminopeptidase activity
J7654_RS06630	COG0477	Major facilitator Superfamily
J7654_RS06635	COG3181	Tripartite tricarboxylate transporter family receptor
J7654_RS06650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J7654_RS06655	COG1522	sequence-specific DNA binding
J7654_RS06660	COG4172	Belongs to the ABC transporter superfamily
J7654_RS06665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS06670	COG0601	transmembrane transport
J7654_RS06695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J7654_RS06700	COG1012	belongs to the aldehyde dehydrogenase family
J7654_RS06710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J7654_RS06715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS06720	COG0601	transmembrane transport
J7654_RS06725	COG0747	negative chemotaxis
J7654_RS06740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J7654_RS06750	COG0745	RESPONSE REGULATOR receiver
J7654_RS06750	COG2205	protein histidine kinase activity
J7654_RS06750	COG4191	Histidine kinase
J7654_RS06755	COG3237	CsbD-like
J7654_RS06775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J7654_RS06780	COG1083	cytidylyl-transferase
J7654_RS06790	COG2089	acid synthase
J7654_RS06805	COG1086	Polysaccharide biosynthesis protein
J7654_RS06865	COG1538	Outer membrane efflux protein
J7654_RS06875	COG1132	(ABC) transporter
J7654_RS06905	COG1414	Transcriptional regulator
J7654_RS06915	COG1024	Enoyl-CoA hydratase
J7654_RS06925	COG0765	amino acid transport
J7654_RS06930	COG1126	abc transporter atp-binding protein
J7654_RS06935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J7654_RS06945	COG0277	FAD linked oxidase domain protein
J7654_RS06950	COG4607	ABC-type enterochelin transport system periplasmic component
J7654_RS06955	COG1120	ATPase activity
J7654_RS06960	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J7654_RS06965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J7654_RS06970	COG0154	amidase activity
J7654_RS07000	COG0251	oxidation-reduction process
J7654_RS07005	COG4608	Belongs to the ABC transporter superfamily
J7654_RS07010	COG0444	Belongs to the ABC transporter superfamily
J7654_RS07030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS07050	COG0747	negative chemotaxis
J7654_RS07055	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J7654_RS07070	COG1396	sequence-specific DNA binding
J7654_RS07070	COG3800	Transcriptional regulator
J7654_RS07075	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J7654_RS07080	COG0346	lactoylglutathione lyase activity
J7654_RS07085	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
J7654_RS07085	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
J7654_RS07090	COG4770	biotin carboxylase activity
J7654_RS07110	COG4774	siderophore transport
J7654_RS07120	COG1238	metal cluster binding
J7654_RS07130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J7654_RS07135	COG1129	ABC transporter
J7654_RS07135	COG0842	Transport permease protein
J7654_RS07140	COG0842	Transport permease protein
J7654_RS07145	COG0471	metal ion transport
J7654_RS07165	COG1744	ABC transporter substrate-binding protein PnrA-like
J7654_RS07175	COG0824	Thioesterase
J7654_RS07180	COG3845	ABC transporter
J7654_RS07185	COG1079	Belongs to the binding-protein-dependent transport system permease family
J7654_RS07190	COG1079	Belongs to the binding-protein-dependent transport system permease family
J7654_RS07200	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
J7654_RS07205	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
J7654_RS07225	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
J7654_RS07230	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
J7654_RS07265	COG4964	Belongs to the GSP D family
J7654_RS07300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J7654_RS07310	COG0791	NLP P60 protein
J7654_RS07320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J7654_RS07325	COG0494	nUDIX hydrolase
J7654_RS07330	COG4172	Belongs to the ABC transporter superfamily
J7654_RS07335	COG4239	(ABC) transporter, permease
J7654_RS07340	COG4174	ABC transporter (Permease)
J7654_RS07345	COG4166	transmembrane transport
J7654_RS07350	COG4166	transmembrane transport
J7654_RS07355	COG3474	cytochrome
J7654_RS07370	COG2816	NAD+ diphosphatase activity
J7654_RS07390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J7654_RS07395	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J7654_RS07400	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J7654_RS07405	COG0778	Nitroreductase
J7654_RS07420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J7654_RS07430	COG0242	peptide deformylase activity
J7654_RS07435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J7654_RS07440	COG0101	tRNA pseudouridine synthase activity
J7654_RS07450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J7654_RS07460	COG2171	N-acyltransferase activity
J7654_RS07475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J7654_RS07485	COG0747	negative chemotaxis
J7654_RS07495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7654_RS07500	COG0444	Belongs to the ABC transporter superfamily
J7654_RS07505	COG4608	Belongs to the ABC transporter superfamily
J7654_RS07510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J7654_RS07510	COG0475	glutathione-regulated potassium exporter activity
J7654_RS07520	COG0586	Pfam SNARE associated Golgi protein
J7654_RS07530	COG4206	TonB-dependent receptor
J7654_RS07535	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
J7654_RS07540	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
J7654_RS07555	COG0583	DNA-binding transcription factor activity
J7654_RS07580	COG2204	response regulator
J7654_RS07585	COG4191	Histidine kinase
J7654_RS07590	COG1301	dicarboxylic acid transport
J7654_RS07605	COG0247	lactate metabolic process
J7654_RS07605	COG2181	nitrate reductase activity
J7654_RS07610	COG1902	pentaerythritol trinitrate reductase activity
J7654_RS07610	COG0446	pyridine nucleotide-disulphide oxidoreductase
J7654_RS07615	COG1017	nitric oxide dioxygenase activity
J7654_RS07615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J7654_RS07625	COG2169	Transcriptional regulator
J7654_RS07625	COG1917	Cupin 2, conserved barrel domain protein
J7654_RS07655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J7654_RS07655	COG0446	pyridine nucleotide-disulphide oxidoreductase
J7654_RS07670	COG1132	(ABC) transporter
J7654_RS07690	COG2205	protein histidine kinase activity
J7654_RS07695	COG0745	RESPONSE REGULATOR receiver
J7654_RS07700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J7654_RS07715	COG0601	transmembrane transport
J7654_RS07725	COG0444	Belongs to the ABC transporter superfamily
J7654_RS07730	COG4608	Belongs to the ABC transporter superfamily
J7654_RS07735	COG1473	amidohydrolase
J7654_RS07740	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J7654_RS07745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J7654_RS07750	COG1216	Glycosyl transferase, family 2
J7654_RS07755	COG0438	transferase activity, transferring glycosyl groups
J7654_RS07760	COG0438	transferase activity, transferring glycosyl groups
J7654_RS07815	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J7654_RS07820	COG1492	cobalamin metabolic process
J7654_RS07890	COG1797	cobyrinic acid a,c-diamide synthase activity
J7654_RS07895	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
J7654_RS07900	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J7654_RS07910	COG4604	ABC transporter, ATP-binding protein
J7654_RS07915	COG4605	iron ion homeostasis
J7654_RS07920	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J7654_RS07925	COG4607	ABC-type enterochelin transport system periplasmic component
J7654_RS07935	COG1136	(ABC) transporter
J7654_RS07935	COG0577	efflux transmembrane transporter activity
J7654_RS07940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J7654_RS07965	COG0765	amino acid transport
J7654_RS07970	COG0765	amino acid transport
J7654_RS08055	COG3852	Histidine kinase
J7654_RS08060	COG0230	Belongs to the bacterial ribosomal protein bL34 family
J7654_RS08065	COG0594	ribonuclease P activity
J7654_RS08075	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J7654_RS08085	COG5328	Belongs to the UPF0262 family
J7654_RS08135	COG0129	dihydroxy-acid dehydratase activity
J7654_RS08140	COG0363	glucosamine-6-phosphate deaminase activity
J7654_RS08145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J7654_RS08150	COG4251	negative regulation of phosphorylation
J7654_RS08160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J7654_RS08175	COG2224	Isocitrate lyase
J7654_RS08180	COG3800	Transcriptional regulator
J7654_RS08180	COG1396	sequence-specific DNA binding
J7654_RS08195	COG3842	ATPase activity
J7654_RS08200	COG1176	ABC-type spermidine putrescine transport system, permease component I
J7654_RS08205	COG1177	transmembrane transport
J7654_RS08235	COG1570	exodeoxyribonuclease VII activity
J7654_RS08240	COG0583	DNA-binding transcription factor activity
J7654_RS08250	COG1253	flavin adenine dinucleotide binding
J7654_RS08270	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS08280	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
J7654_RS08285	COG1376	ErfK ybiS ycfS ynhG family protein
J7654_RS08290	COG1376	ErfK ybiS ycfS ynhG family protein
J7654_RS08300	COG2818	Glycosylase
J7654_RS08305	COG0124	histidyl-tRNA synthetase
J7654_RS08310	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
J7654_RS08315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J7654_RS08330	COG3237	CsbD-like
J7654_RS08335	COG0459	protein refolding
J7654_RS08355	COG0196	riboflavin kinase activity
J7654_RS08370	COG0590	tRNA wobble adenosine to inosine editing
J7654_RS08375	COG1187	pseudouridine synthase activity
J7654_RS08380	COG0742	ribosomal rna small subunit methyltransferase
J7654_RS08385	COG0612	Peptidase, M16
J7654_RS08390	COG0612	Peptidase, M16
J7654_RS08395	COG1752	Esterase of the alpha-beta hydrolase superfamily
J7654_RS08405	COG0312	modulator of DNA gyrase
J7654_RS08410	COG0483	inositol monophosphate 1-phosphatase activity
J7654_RS08425	COG1519	Transferase
J7654_RS08430	COG1663	tetraacyldisaccharide 4'-kinase activity
J7654_RS08440	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J7654_RS08450	COG0033	Phosphoglucomutase
J7654_RS08455	COG0297	glycogen (starch) synthase activity
J7654_RS08460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J7654_RS08465	COG0058	SHG alpha-glucan phosphorylase activity
J7654_RS08470	COG0166	Belongs to the GPI family
J7654_RS08480	COG0729	surface antigen
J7654_RS08510	COG1294	oxidase, subunit
J7654_RS08515	COG1271	oxidase subunit
J7654_RS08525	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
J7654_RS08530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J7654_RS08575	COG0070	glutamate synthase
J7654_RS08575	COG0067	glutamate synthase
J7654_RS08575	COG0069	glutamate synthase activity
J7654_RS08585	COG0071	Belongs to the small heat shock protein (HSP20) family
J7654_RS08640	COG1396	sequence-specific DNA binding
J7654_RS08645	COG1473	amidohydrolase
J7654_RS08650	COG1686	Belongs to the peptidase S11 family
J7654_RS08655	COG0523	cobalamin synthesis protein
J7654_RS08660	COG0425	Belongs to the sulfur carrier protein TusA family
J7654_RS08660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J7654_RS08675	COG2032	superoxide dismutase activity
J7654_RS08700	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
J7654_RS08705	COG1396	sequence-specific DNA binding
J7654_RS08720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J7654_RS08740	COG3451	type IV secretory pathway VirB4
J7654_RS08795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J7654_RS08815	COG2086	electron transfer activity
J7654_RS08820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
J7654_RS08825	COG1250	3-hydroxyacyl-CoA dehydrogenase
J7654_RS08830	COG2824	Alkylphosphonate utilization operon protein PhnA
J7654_RS08840	COG1376	ErfK ybiS ycfS ynhG family protein
J7654_RS08850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J7654_RS08855	COG0165	Argininosuccinate lyase
J7654_RS08875	COG4106	trans-aconitate 2-methyltransferase activity
J7654_RS08895	COG2884	Cell division ATP-binding protein ftsE
J7654_RS08925	COG0287	Prephenate dehydrogenase
J7654_RS08930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J7654_RS08935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J7654_RS08940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J7654_RS08940	COG2813	Specifically methylates the guanine in position
J7654_RS08955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J7654_RS08965	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J7654_RS08970	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J7654_RS09005	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J7654_RS09010	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J7654_RS09025	COG0825	malonyl-CoA metabolic process
J7654_RS09040	COG0653	protein targeting
J7654_RS09045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J7654_RS09050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J7654_RS09060	COG0494	nUDIX hydrolase
J7654_RS09070	COG2226	methyltransferase
J7654_RS09075	COG1040	competence protein
J7654_RS09105	COG0783	Belongs to the Dps family
J7654_RS09115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J7654_RS09120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J7654_RS09125	COG0527	aspartate kinase activity
J7654_RS09130	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
J7654_RS09135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J7654_RS09140	COG2890	protein-(glutamine-N5) methyltransferase activity
J7654_RS09150	COG0542	response to heat
J7654_RS09160	COG1376	ErfK ybiS ycfS ynhG family protein
J7654_RS09175	COG0739	heme binding
J7654_RS09215	COG3119	arylsulfatase activity
J7654_RS09220	COG1653	transport
J7654_RS09225	COG1175	transmembrane transport
J7654_RS09230	COG0395	ABC-type sugar transport system, permease component
J7654_RS09235	COG3842	ATPase activity
J7654_RS09250	COG1877	trehalose-phosphatase activity
J7654_RS09255	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
J7654_RS09260	COG0800	Aldolase
J7654_RS09280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J7654_RS09285	COG1609	Transcriptional regulator
J7654_RS09290	COG0523	cobalamin synthesis protein
J7654_RS09310	COG0583	DNA-binding transcription factor activity
J7654_RS09340	COG2137	regulation of response to DNA damage stimulus
J7654_RS09345	COG0693	protein deglycase activity
J7654_RS09385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J7654_RS09395	COG1830	Aldolase
J7654_RS09405	COG1121	(ABC) transporter
J7654_RS09410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J7654_RS09445	COG5001	Diguanylate cyclase
J7654_RS09445	COG3300	MHYT domain
J7654_RS09455	COG0433	COG0433 Predicted ATPase
J7654_RS09465	COG1376	ErfK ybiS ycfS ynhG family protein
J7654_RS09470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J7654_RS09475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J7654_RS09485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J7654_RS09485	COG2111	Na H antiporter
J7654_RS09490	COG2111	Na H antiporter
J7654_RS09495	COG1006	Multisubunit Na H antiporter MnhC subunit
J7654_RS09500	COG0651	ATP synthesis coupled electron transport
J7654_RS09505	COG1863	multisubunit Na H antiporter MnhE subunit
J7654_RS09510	COG2212	antiporter activity
J7654_RS09515	COG1320	monovalent cation:proton antiporter activity
J7654_RS09525	COG5001	Diguanylate cyclase
J7654_RS09525	COG3300	MHYT domain
J7654_RS09530	COG1157	protein secretion by the type III secretion system
J7654_RS09535	COG4786	Flagellar basal body rod
J7654_RS09540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
J7654_RS09555	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
J7654_RS09560	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
J7654_RS09565	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J7654_RS09575	COG1815	bacterial-type flagellum-dependent cell motility
J7654_RS09580	COG1558	bacterial-type flagellum-dependent cell motility
J7654_RS09585	COG1677	Flagellar hook-basal body complex protein FliE
J7654_RS09590	COG4786	Flagellar basal body rod
J7654_RS09595	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
J7654_RS09600	COG1706	bacterial-type flagellum-dependent cell motility
J7654_RS09605	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
J7654_RS09615	COG1338	Plays a role in the flagellum-specific transport system
J7654_RS09620	COG1766	The M ring may be actively involved in energy transduction
J7654_RS09630	COG1360	Flagellar Motor Protein
J7654_RS09650	COG1749	Flagellar hook protein flgE
J7654_RS09665	COG5442	Flagellar protein FlaF
J7654_RS09670	COG5443	negative regulation of bacterial-type flagellum assembly
J7654_RS09680	COG1987	bacterial-type flagellum assembly
J7654_RS09685	COG5507	3-demethylubiquinone-9 3-methyltransferase
J7654_RS09700	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J7654_RS09750	COG0513	Belongs to the DEAD box helicase family
J7654_RS09755	COG0488	(ABC) transporter
J7654_RS09760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J7654_RS09775	COG1803	Methylglyoxal synthase
J7654_RS09775	COG1597	lipid kinase activity
J7654_RS09810	COG0784	Response regulator, receiver
J7654_RS09815	COG2202	Pas domain
J7654_RS09815	COG3920	Histidine kinase
J7654_RS09835	COG4175	Glycine betaine
J7654_RS09840	COG4176	ABC-type proline glycine betaine transport system permease component
J7654_RS09855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J7654_RS09855	COG0512	Glutamine amidotransferase of anthranilate synthase
J7654_RS09860	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J7654_RS09865	COG0563	adenylate kinase activity
J7654_RS09870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J7654_RS09885	COG0435	Glutathione S-transferase
J7654_RS09915	COG0714	Associated with various cellular activities
J7654_RS09930	COG0617	tRNA 3'-terminal CCA addition
J7654_RS09940	COG0408	coproporphyrinogen oxidase activity
J7654_RS09950	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J7654_RS09955	COG1132	(ABC) transporter
J7654_RS09960	COG1132	(ABC) transporter
J7654_RS09965	COG0723	plastoquinol--plastocyanin reductase activity
J7654_RS09975	COG2857	Cytochrome c1
J7654_RS09975	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J7654_RS09985	COG0193	aminoacyl-tRNA hydrolase activity
J7654_RS09990	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J7654_RS10020	COG1496	oxidoreductase activity
J7654_RS10030	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J7654_RS10050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J7654_RS10060	COG0745	RESPONSE REGULATOR receiver
J7654_RS10065	COG1846	Transcriptional regulator
J7654_RS10075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J7654_RS10085	COG1278	Cold shock
J7654_RS10100	COG1064	alcohol dehydrogenase
J7654_RS10105	COG0556	nucleotide-excision repair
J7654_RS10110	COG1388	LysM domain
J7654_RS10110	COG3858	chitin binding
J7654_RS10120	COG0515	serine threonine protein kinase
J7654_RS10140	COG0625	glutathione transferase activity
J7654_RS10145	COG0436	Aminotransferase
J7654_RS10150	COG0513	Belongs to the DEAD box helicase family
J7654_RS10155	COG0583	DNA-binding transcription factor activity
J7654_RS10160	COG0492	ferredoxin-NADP+ reductase activity
J7654_RS10165	COG5265	(ABC) transporter
J7654_RS10170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J7654_RS10180	COG0438	transferase activity, transferring glycosyl groups
J7654_RS10190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J7654_RS10200	COG0505	Belongs to the CarA family
J7654_RS10205	COG1346	cytolysis
J7654_RS10220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J7654_RS10225	COG3300	MHYT domain
J7654_RS10225	COG5001	Diguanylate cyclase
J7654_RS10250	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J7654_RS10255	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS10290	COG0546	phosphoglycolate phosphatase activity
J7654_RS10295	COG4172	Belongs to the ABC transporter superfamily
J7654_RS10305	COG0601	transmembrane transport
J7654_RS10315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J7654_RS10325	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
J7654_RS10325	COG0517	IMP dehydrogenase activity
J7654_RS10335	COG0330	HflC and HflK could
J7654_RS10340	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J7654_RS10355	COG5310	Homospermidine synthase
J7654_RS10375	COG4957	zinc ion binding
J7654_RS10380	COG3750	Belongs to the UPF0335 family
J7654_RS10395	COG0469	pyruvate kinase activity
J7654_RS10405	COG0457	Tetratricopeptide repeat
J7654_RS10410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J7654_RS10415	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
J7654_RS10420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
J7654_RS10435	COG0352	thiamine-phosphate diphosphorylase activity
J7654_RS10445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J7654_RS10450	COG0483	inositol monophosphate 1-phosphatase activity
J7654_RS10465	COG1132	(ABC) transporter
J7654_RS10470	COG0254	rRNA binding
J7654_RS10490	COG3387	PFAM Glycoside hydrolase 15-related
J7654_RS10500	COG5002	protein histidine kinase activity
J7654_RS10505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J7654_RS10510	COG0573	inorganic phosphate transmembrane transporter activity
J7654_RS10520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J7654_RS10525	COG0704	Plays a role in the regulation of phosphate uptake
J7654_RS10530	COG0745	RESPONSE REGULATOR receiver
J7654_RS10545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J7654_RS10560	COG2967	ApaG domain
J7654_RS10570	COG0717	Belongs to the dCTP deaminase family
J7654_RS10595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J7654_RS10655	COG1024	Enoyl-CoA hydratase
J7654_RS10655	COG1250	3-hydroxyacyl-CoA dehydrogenase
J7654_RS10660	COG0183	Belongs to the thiolase family
J7654_RS10665	COG1960	acyl-CoA dehydrogenase activity
J7654_RS10695	COG1201	RNA secondary structure unwinding
J7654_RS10720	COG0126	phosphoglycerate kinase activity
J7654_RS10750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J7654_RS10760	COG0625	glutathione transferase activity
J7654_RS10765	COG1692	metallophosphoesterase
J7654_RS10775	COG0217	transcriptional regulatory protein
J7654_RS10780	COG3409	Peptidoglycan-binding domain 1 protein
J7654_RS10780	COG3773	Cell wall hydrolase
J7654_RS10790	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J7654_RS10805	COG0632	four-way junction helicase activity
J7654_RS10810	COG2255	four-way junction helicase activity
J7654_RS10815	COG1064	alcohol dehydrogenase
J7654_RS10820	COG0824	Thioesterase
J7654_RS10830	COG0848	biopolymer transport protein
J7654_RS10845	COG2885	chlorophyll binding
J7654_RS10855	COG0037	tRNA processing
J7654_RS10860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J7654_RS10865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J7654_RS10890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J7654_RS10900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J7654_RS10910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J7654_RS10915	COG0564	pseudouridine synthase activity
J7654_RS10955	COG0745	RESPONSE REGULATOR receiver
J7654_RS10970	COG0482	sulfurtransferase activity
J7654_RS10975	COG0673	inositol 2-dehydrogenase activity
J7654_RS10990	COG5265	(ABC) transporter
J7654_RS10995	COG0688	phosphatidylethanolamine metabolic process
J7654_RS11000	COG1183	phosphatidylcholine synthase activity
J7654_RS11005	COG4221	oxidoreductase activity
J7654_RS11010	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
J7654_RS11025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J7654_RS11035	COG0359	binds to the 23S rRNA
J7654_RS11055	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J7654_RS11065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J7654_RS11070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J7654_RS11075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J7654_RS11080	COG1561	YicC-like family, N-terminal region
J7654_RS11085	COG0194	GDP metabolic process
J7654_RS11090	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J7654_RS11095	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J7654_RS11105	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
J7654_RS11120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J7654_RS11135	COG0488	(ABC) transporter
J7654_RS11140	COG0105	UTP biosynthetic process
J7654_RS11145	COG0314	molybdopterin synthase activity
J7654_RS11155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J7654_RS11160	COG0322	excinuclease ABC activity
J7654_RS11180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J7654_RS11185	COG0243	molybdopterin cofactor binding
J7654_RS11190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J7654_RS11195	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J7654_RS11200	COG0628	permease
J7654_RS11210	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J7654_RS11220	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
J7654_RS11225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J7654_RS11235	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J7654_RS11250	COG0113	porphobilinogen synthase activity
J7654_RS11270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J7654_RS11275	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J7654_RS11280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J7654_RS11280	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J7654_RS11295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J7654_RS11315	COG0416	fatty acid biosynthetic process
J7654_RS11325	COG0776	regulation of translation
J7654_RS11360	COG0583	DNA-binding transcription factor activity
J7654_RS11370	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J7654_RS11375	COG3485	protocatechuate 3,4-dioxygenase
J7654_RS11380	COG3485	protocatechuate 3,4-dioxygenase
J7654_RS11390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J7654_RS11395	COG0183	Belongs to the thiolase family
J7654_RS11405	COG1840	ABC-type Fe3 transport system, periplasmic component
J7654_RS11415	COG3842	ATPase activity
J7654_RS11420	COG2971	BadF BadG BcrA BcrD
J7654_RS11430	COG1596	polysaccharide export
J7654_RS11445	COG1612	heme a metabolic process
J7654_RS11450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J7654_RS11455	COG0010	Belongs to the arginase family
J7654_RS11465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J7654_RS11470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J7654_RS11480	COG2124	cytochrome p450
J7654_RS11490	COG0431	NADPH-dependent FMN reductase
J7654_RS11495	COG5002	protein histidine kinase activity
J7654_RS11520	COG0508	dehydrogenase complex catalyzes the overall conversion of
J7654_RS11525	COG0022	dehydrogenase e1 component
J7654_RS11540	COG3327	negative regulation of DNA-templated transcription, initiation
J7654_RS11545	COG3396	Phenylacetate-CoA oxygenase
J7654_RS11550	COG3460	Phenylacetate-CoA oxygenase
J7654_RS11555	COG3396	Phenylacetate-CoA oxygenase
J7654_RS11560	COG2151	metal-sulfur cluster biosynthetic enzyme
J7654_RS11565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J7654_RS11570	COG2030	dehydratase
J7654_RS11570	COG1012	belongs to the aldehyde dehydrogenase family
J7654_RS11575	COG1024	Enoyl-CoA hydratase
J7654_RS11580	COG2050	protein possibly involved in aromatic compounds catabolism
J7654_RS11590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J7654_RS11605	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
J7654_RS11610	COG0420	3'-5' exonuclease activity
J7654_RS11630	COG0741	lytic transglycosylase activity
J7654_RS11640	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J7654_RS11650	COG1573	uracil-dna glycosylase
J7654_RS11660	COG1758	RNA polymerase activity
J7654_RS11670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J7654_RS11675	COG0736	holo-[acyl-carrier-protein] synthase activity
J7654_RS11680	COG0681	Belongs to the peptidase S26 family
J7654_RS11690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J7654_RS11700	COG0546	phosphoglycolate phosphatase activity
J7654_RS11810	COG0653	protein targeting
J7654_RS11895	COG1522	sequence-specific DNA binding
J7654_RS11915	COG0747	negative chemotaxis
J7654_RS11930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J7654_RS11955	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
J7654_RS11970	COG0232	Belongs to the dGTPase family. Type 2 subfamily
J7654_RS11975	COG0018	arginyl-trna synthetase
J7654_RS11985	COG1472	Belongs to the glycosyl hydrolase 3 family
J7654_RS11990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J7654_RS11995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J7654_RS12000	COG0805	protein transport
J7654_RS12005	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J7654_RS12010	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J7654_RS12015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J7654_RS12020	COG1388	LysM domain
J7654_RS12020	COG0739	heme binding
J7654_RS12030	COG1862	Preprotein translocase
J7654_RS12040	COG3737	Protein of unknown function (DUF498/DUF598)
J7654_RS12055	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
J7654_RS12070	COG0544	peptidyl-prolyl cis-trans isomerase activity
J7654_RS12075	COG0668	transmembrane transport
J7654_RS12080	COG0740	serine-type endopeptidase activity
J7654_RS12085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J7654_RS12095	COG0776	regulation of translation
J7654_RS12115	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J7654_RS12120	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J7654_RS12125	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J7654_RS12135	COG0649	NAD binding
J7654_RS12140	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
J7654_RS12145	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J7654_RS12155	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J7654_RS12160	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J7654_RS12170	COG0713	ATP synthesis coupled electron transport
J7654_RS12185	COG1007	ATP synthesis coupled electron transport
J7654_RS12205	COG0442	prolyl-tRNA aminoacylation
J7654_RS12220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J7654_RS12235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J7654_RS12255	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J7654_RS12265	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J7654_RS12270	COG0081	regulation of translation
J7654_RS12275	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J7654_RS12280	COG0222	ribosome binding
J7654_RS12285	COG0085	RNA polymerase activity
J7654_RS12290	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J7654_RS12295	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J7654_RS12300	COG0049	tRNA binding
J7654_RS12305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J7654_RS12310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J7654_RS12315	COG0051	transcription antitermination factor activity, RNA binding
J7654_RS12325	COG0088	Forms part of the polypeptide exit tunnel
J7654_RS12335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J7654_RS12340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J7654_RS12355	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J7654_RS12365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J7654_RS12370	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J7654_RS12375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J7654_RS12380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J7654_RS12385	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J7654_RS12400	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J7654_RS12405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J7654_RS12415	COG0200	Binds to the 23S rRNA
J7654_RS12420	COG0201	protein transport
J7654_RS12425	COG0563	adenylate kinase activity
J7654_RS12430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J7654_RS12440	COG0202	RNA polymerase activity
J7654_RS12445	COG0203	ribosomal protein L17
J7654_RS12450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J7654_RS12465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J7654_RS12495	COG1671	Belongs to the UPF0178 family
J7654_RS12500	COG0321	lipoyl(octanoyl) transferase activity
J7654_RS12510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J7654_RS12515	COG2239	Acts as a magnesium transporter
J7654_RS12530	COG0656	L-ascorbic acid biosynthetic process
J7654_RS12560	COG0484	heat shock protein binding
J7654_RS12565	COG1686	Belongs to the peptidase S11 family
J7654_RS12570	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J7654_RS12590	COG0537	adenosine 5'-monophosphoramidase activity
J7654_RS12605	COG0251	oxidation-reduction process
J7654_RS12615	COG0052	Belongs to the universal ribosomal protein uS2 family
J7654_RS12620	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J7654_RS12625	COG0528	UMP kinase activity
J7654_RS12635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J7654_RS12645	COG0750	zinc metalloprotease
J7654_RS12655	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J7654_RS12660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J7654_RS12665	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J7654_RS12675	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J7654_RS12680	COG0372	Belongs to the citrate synthase family
J7654_RS12695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J7654_RS12700	COG0303	'Molybdopterin
J7654_RS12710	COG0134	indole-3-glycerol-phosphate synthase activity
J7654_RS12715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J7654_RS12725	COG0149	triose-phosphate isomerase activity
J7654_RS12735	COG0504	CTP synthase activity
J7654_RS12750	COG0148	phosphopyruvate hydratase activity
J7654_RS12760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J7654_RS12765	COG0022	dehydrogenase e1 component
J7654_RS12765	COG0508	dehydrogenase complex catalyzes the overall conversion of
J7654_RS12775	COG0508	dehydrogenase complex catalyzes the overall conversion of
J7654_RS12780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J7654_RS12790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J7654_RS12795	COG2867	negative regulation of translational initiation
J7654_RS12805	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J7654_RS12805	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J7654_RS12820	COG3852	Histidine kinase
J7654_RS12825	COG2204	response regulator
J7654_RS12830	COG5000	phosphorelay sensor kinase activity
J7654_RS12835	COG2204	response regulator
J7654_RS12840	COG0569	domain protein
J7654_RS12850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J7654_RS12855	COG3956	TIGRFAM MazG family protein
J7654_RS12860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J7654_RS12865	COG3920	Histidine kinase
J7654_RS12870	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
J7654_RS12880	COG1058	Belongs to the CinA family
J7654_RS12880	COG1546	Belongs to the CinA family
J7654_RS12885	COG0655	NAD(P)H dehydrogenase (quinone) activity
J7654_RS12900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J7654_RS12910	COG0737	Belongs to the 5'-nucleotidase family
J7654_RS12920	COG2897	thiosulfate sulfurtransferase activity
J7654_RS13170	COG1475	DNA binding
J7654_RS13205	COG1061	Type III restriction enzyme res subunit
J7654_RS13245	COG1396	sequence-specific DNA binding
J7654_RS13250	COG2856	Zn peptidase
J7654_RS13285	COG1597	lipid kinase activity
J7654_RS13305	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J7654_RS13310	COG1686	Belongs to the peptidase S11 family
J7654_RS13330	COG0084	hydrolase, TatD family'
J7654_RS13350	COG1183	phosphatidylcholine synthase activity
J7654_RS13355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J7654_RS13370	COG4166	transmembrane transport
J7654_RS13375	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J7654_RS13385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J7654_RS13395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J7654_RS13400	COG0785	Cytochrome C biogenesis protein
J7654_RS13415	COG1295	ribonuclease BN
J7654_RS13415	COG1959	2 iron, 2 sulfur cluster binding
J7654_RS13420	COG2066	Belongs to the glutaminase family
J7654_RS13425	COG0343	queuine tRNA-ribosyltransferase activity
J7654_RS13430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J7654_RS13445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J7654_RS13455	COG0629	single-stranded DNA binding
J7654_RS13465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J7654_RS13475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J7654_RS13475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J7654_RS13480	COG0347	Belongs to the P(II) protein family
J7654_RS13485	COG0174	glutamine synthetase
J7654_RS13490	COG0187	DNA topoisomerase II activity
J7654_RS13505	COG0316	Belongs to the HesB IscA family
J7654_RS13515	COG2151	metal-sulfur cluster biosynthetic enzyme
J7654_RS13520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J7654_RS13525	COG0719	Fe-S assembly protein
J7654_RS13530	COG0396	ATPase activity
J7654_RS13535	COG0719	Fe-S assembly protein
J7654_RS13545	COG2945	thiolester hydrolase activity
J7654_RS13550	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J7654_RS13560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J7654_RS13565	COG0739	heme binding
J7654_RS13575	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J7654_RS13580	COG0860	N-Acetylmuramoyl-L-alanine amidase
J7654_RS13585	COG1530	ribonuclease E activity
J7654_RS13590	COG0436	Aminotransferase
J7654_RS13595	COG0501	Belongs to the peptidase M48B family
J7654_RS13605	COG0511	ligase activity, forming carbon-carbon bonds
J7654_RS13615	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J7654_RS13620	COG4765	Protein conserved in bacteria
J7654_RS13630	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J7654_RS13645	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J7654_RS13650	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
J7654_RS13655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J7654_RS13665	COG0540	Belongs to the ATCase OTCase family
J7654_RS13670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J7654_RS13680	COG0758	DNA mediated transformation
J7654_RS13685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J7654_RS13685	COG1754	DNA topoisomerase type I activity
J7654_RS13690	COG0557	exoribonuclease II activity
J7654_RS13705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J7654_RS13720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J7654_RS13740	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
J7654_RS13745	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
J7654_RS13835	COG0673	inositol 2-dehydrogenase activity
J7654_RS13855	COG1793	dna ligase
J7654_RS13900	COG3416	Protein conserved in bacteria
J7654_RS13905	COG0546	phosphoglycolate phosphatase activity
J7654_RS13915	COG0367	asparagine synthase
J7654_RS13925	COG1363	Peptidase, m42
J7654_RS13930	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J7654_RS13935	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J7654_RS13945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J7654_RS13975	COG0302	gtp cyclohydrolase
J7654_RS13980	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J7654_RS13985	COG1752	Esterase of the alpha-beta hydrolase superfamily
J7654_RS13990	COG0516	GMP reductase activity
J7654_RS13990	COG0517	IMP dehydrogenase activity
J7654_RS14015	COG1045	serine acetyltransferase
J7654_RS14020	COG0596	Alpha beta hydrolase
J7654_RS14045	COG0628	permease
J7654_RS14050	COG1126	abc transporter atp-binding protein
J7654_RS14055	COG0765	amino acid transport
J7654_RS14060	COG4597	amino acid ABC transporter
J7654_RS14065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J7654_RS14070	COG0626	cystathionine gamma-synthase activity
J7654_RS14075	COG0671	phosphoesterase, PA-phosphatase related
J7654_RS14085	COG3547	Transposase (IS116 IS110 IS902 family)
J7654_RS14135	COG1278	Cold shock
J7654_RS14160	COG1494	fructose-1,6-bisphosphatase
J7654_RS14175	COG0436	Aminotransferase
J7654_RS14185	COG3243	poly(R)-hydroxyalkanoic acid synthase
J7654_RS14190	COG0024	Methionine aminopeptidase
J7654_RS14195	COG2003	Belongs to the UPF0758 family
J7654_RS14200	COG5425	PFAM Usg family protein
J7654_RS14205	COG2068	MobA-Related Protein
J7654_RS14210	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
J7654_RS14210	COG3608	succinylglutamate desuccinylase aspartoacylase
J7654_RS14220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J7654_RS14235	COG3191	aminopeptidase activity
J7654_RS14245	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J7654_RS14260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J7654_RS14275	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J7654_RS14280	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J7654_RS14285	COG0047	phosphoribosylformylglycinamidine synthase activity
J7654_RS14305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J7654_RS14315	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J7654_RS14320	COG2814	Major facilitator Superfamily
J7654_RS14325	COG0037	tRNA processing
J7654_RS14330	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J7654_RS14340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J7654_RS14345	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
J7654_RS14350	COG0538	isocitrate dehydrogenase activity
J7654_RS14360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J7654_RS14390	COG3106	COG3106 Predicted ATPase
J7654_RS14395	COG3768	UPF0283 membrane protein
J7654_RS14405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J7654_RS14410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J7654_RS14420	COG0633	Ferredoxin
J7654_RS14430	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J7654_RS14430	COG3218	ABC-type transport auxiliary lipoprotein component
J7654_RS14440	COG1127	ABC transporter
J7654_RS14445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J7654_RS14450	COG4948	Mandelate Racemase Muconate Lactonizing
J7654_RS14455	COG0280	phosphate acetyltransferase
J7654_RS14455	COG0281	malic enzyme
J7654_RS14475	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
J7654_RS14500	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J7654_RS14510	COG0673	inositol 2-dehydrogenase activity
J7654_RS14515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J7654_RS14530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J7654_RS14530	COG0574	Belongs to the PEP-utilizing enzyme family
J7654_RS14535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J7654_RS14555	COG1194	a g-specific adenine glycosylase
J7654_RS14560	COG2189	Belongs to the N(4) N(6)-methyltransferase family
J7654_RS14565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J7654_RS14580	COG0612	Peptidase, M16
J7654_RS14590	COG5001	Diguanylate cyclase
J7654_RS14595	COG1678	Uncharacterized ACR, COG1678
J7654_RS14605	COG0678	peroxiredoxin activity
J7654_RS14605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
J7654_RS14610	COG0328	RNA-DNA hybrid ribonuclease activity
J7654_RS14615	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
J7654_RS14620	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J7654_RS14625	COG3346	SURF1 family
J7654_RS14640	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
J7654_RS14650	COG0109	protoheme IX farnesyltransferase activity
J7654_RS14655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J7654_RS14660	COG1565	acr, cog1565
J7654_RS14660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J7654_RS14670	COG0312	modulator of DNA gyrase
J7654_RS14675	COG0259	pyridoxamine-phosphate oxidase activity
J7654_RS14685	COG0484	heat shock protein binding
J7654_RS14690	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J7654_RS14695	COG0406	alpha-ribazole phosphatase activity
J7654_RS14710	COG0123	including yeast histone deacetylase and acetoin utilization protein
J7654_RS14715	COG1722	exodeoxyribonuclease VII activity
J7654_RS14720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J7654_RS14735	COG1024	Enoyl-CoA hydratase
J7654_RS14740	COG1960	acyl-CoA dehydrogenase activity
J7654_RS14750	COG0151	Belongs to the GarS family
J7654_RS14770	COG0009	L-threonylcarbamoyladenylate synthase
J7654_RS14785	COG0751	glycine-tRNA ligase activity
J7654_RS14790	COG2321	neutral zinc metallopeptidase
J7654_RS14795	COG0752	glycyl-tRNA synthetase alpha subunit
J7654_RS14815	COG0142	geranyltranstransferase activity
J7654_RS14825	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J7654_RS14830	COG0521	Mo-molybdopterin cofactor biosynthetic process
J7654_RS14845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J7654_RS14850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J7654_RS14855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J7654_RS14860	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J7654_RS14865	COG0356	it plays a direct role in the translocation of protons across the membrane
J7654_RS14880	COG1160	GTP binding
J7654_RS14920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J7654_RS14950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J7654_RS14965	COG0778	Nitroreductase
J7654_RS14970	COG1733	regulation of RNA biosynthetic process
J7654_RS15025	COG0583	DNA-binding transcription factor activity
J7654_RS15040	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS15055	COG0251	oxidation-reduction process
J7654_RS15130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J7654_RS15140	COG0582	viral genome integration into host DNA
J7654_RS15145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J7654_RS15145	COG0519	Catalyzes the synthesis of GMP from XMP
J7654_RS15160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J7654_RS15160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J7654_RS15165	COG0753	catalase activity
J7654_RS15180	COG1234	tRNA 3'-trailer cleavage
J7654_RS15185	COG0477	Major facilitator Superfamily
J7654_RS15190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
J7654_RS15205	COG0251	oxidation-reduction process
J7654_RS15230	COG1177	transmembrane transport
J7654_RS15235	COG1176	ABC-type spermidine putrescine transport system, permease component I
J7654_RS15240	COG3842	ATPase activity
J7654_RS15260	COG5001	Diguanylate cyclase
J7654_RS15270	COG0602	queuosine metabolic process
J7654_RS15275	COG0720	synthase
J7654_RS15280	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J7654_RS15330	COG1959	2 iron, 2 sulfur cluster binding
J7654_RS15365	COG1268	BioY protein
J7654_RS15370	COG1122	ATPase activity
J7654_RS15400	COG0215	cysteine-tRNA ligase activity
J7654_RS15410	COG2135	peptidase activity
J7654_RS15435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J7654_RS15445	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
J7654_RS15465	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
J7654_RS15470	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
J7654_RS15475	COG1381	Involved in DNA repair and RecF pathway recombination
J7654_RS15500	COG0156	8-amino-7-oxononanoate synthase activity
J7654_RS15515	COG1970	mechanosensitive ion channel activity
J7654_RS15520	COG0432	Pfam Uncharacterised protein family UPF0047
J7654_RS15535	COG0167	dihydroorotate dehydrogenase activity
J7654_RS15540	COG0123	including yeast histone deacetylase and acetoin utilization protein
J7654_RS15555	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J7654_RS15560	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J7654_RS15560	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J7654_RS15575	COG0625	glutathione transferase activity
J7654_RS15585	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
J7654_RS15610	COG1573	uracil-dna glycosylase
J7654_RS15625	COG0308	aminopeptidase N
J7654_RS15630	COG2202	Pas domain
J7654_RS15630	COG2205	protein histidine kinase activity
J7654_RS15645	COG0745	RESPONSE REGULATOR receiver
J7654_RS15650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J7654_RS15655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J7654_RS15655	COG1648	precorrin-2 dehydrogenase activity
J7654_RS15660	COG3088	subunit of a heme lyase
J7654_RS15665	COG1138	Cytochrome C-type biogenesis protein
J7654_RS15670	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J7654_RS15675	COG4235	cytochrome complex assembly
J7654_RS15780	COG4695	Portal protein
J7654_RS15795	COG2983	Belongs to the UPF0260 family
J7654_RS15800	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J7654_RS15830	COG3773	Cell wall hydrolase
J7654_RS15830	COG3409	Peptidoglycan-binding domain 1 protein
J7654_RS15835	COG2205	protein histidine kinase activity
J7654_RS15845	COG2166	iron-sulfur cluster assembly
J7654_RS15855	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J7654_RS15870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J7654_RS15875	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J7654_RS15880	COG2080	2 iron, 2 sulfur cluster binding
J7654_RS15885	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
J7654_RS15890	COG0534	Mate efflux family protein
J7654_RS15910	COG1595	DNA-templated transcription, initiation
J7654_RS15915	COG5001	Diguanylate cyclase
J7654_RS15915	COG3300	MHYT domain
J7654_RS15930	COG3546	catalase activity
J7654_RS15945	COG1012	belongs to the aldehyde dehydrogenase family
J7654_RS16025	COG0784	Response regulator, receiver
J7654_RS16025	COG2198	Histidine kinase
J7654_RS16025	COG5002	protein histidine kinase activity
J7654_RS16060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J7654_RS16075	COG0583	DNA-binding transcription factor activity
J7654_RS16080	COG0840	transmembrane signaling receptor activity
J7654_RS16085	COG0346	lactoylglutathione lyase activity
J7654_RS16090	COG1218	3'(2'),5'-bisphosphate nucleotidase
J7654_RS16095	COG1070	Carbohydrate kinase
J7654_RS16100	COG2115	Belongs to the xylose isomerase family
J7654_RS16105	COG1609	Transcriptional regulator
J7654_RS16115	COG4213	ABC transporter substrate-binding protein
J7654_RS16120	COG4214	carbohydrate transport
J7654_RS16125	COG1129	ABC transporter
J7654_RS16135	COG3290	protein histidine kinase activity
J7654_RS16135	COG0840	transmembrane signaling receptor activity
J7654_RS16140	COG0745	RESPONSE REGULATOR receiver
J7654_RS16145	COG2198	Histidine kinase
J7654_RS16145	COG0643	Histidine kinase
J7654_RS16150	COG0835	chemotaxis
J7654_RS16155	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J7654_RS16160	COG2201	protein-glutamate methylesterase activity
J7654_RS16165	COG0745	RESPONSE REGULATOR receiver
J7654_RS16170	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
J7654_RS16180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J7654_RS16190	COG1120	ATPase activity
J7654_RS16195	COG4774	siderophore transport
J7654_RS16200	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
J7654_RS16205	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
J7654_RS16220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J7654_RS16230	COG1686	Belongs to the peptidase S11 family
J7654_RS16240	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J7654_RS16250	COG1686	Belongs to the peptidase S11 family
J7654_RS16255	COG2308	Evidence 4 Homologs of previously reported genes of
J7654_RS16275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J7654_RS16285	COG0697	spore germination
J7654_RS16290	COG2814	Major facilitator Superfamily
J7654_RS16295	COG0746	molybdenum cofactor guanylyltransferase activity
J7654_RS16300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J7654_RS16315	COG1522	sequence-specific DNA binding
J7654_RS16320	COG1573	uracil-dna glycosylase
J7654_RS16335	COG3577	Aspartyl protease
J7654_RS16345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J7654_RS16355	COG0583	DNA-binding transcription factor activity
J7654_RS16360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J7654_RS16370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J7654_RS16385	COG5001	Diguanylate cyclase
J7654_RS16390	COG0784	Response regulator, receiver
J7654_RS16395	COG4176	ABC-type proline glycine betaine transport system permease component
J7654_RS16400	COG0517	IMP dehydrogenase activity
J7654_RS16400	COG4175	Glycine betaine
J7654_RS16425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J7654_RS16450	COG0492	ferredoxin-NADP+ reductase activity
J7654_RS16460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J7654_RS16470	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J7654_RS16480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J7654_RS16490	COG0440	acetolactate synthase activity
J7654_RS16495	COG0028	Belongs to the TPP enzyme family
J7654_RS16505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J7654_RS16510	COG0560	Phosphoserine phosphatase
J7654_RS16525	COG0330	HflC and HflK could
J7654_RS16535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J7654_RS16585	COG1999	signal sequence binding
J7654_RS16590	COG2264	protein methyltransferase activity
J7654_RS16630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J7654_RS16635	COG0497	DNA recombination
J7654_RS16640	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J7654_RS16650	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J7654_RS16655	COG0849	cell division
J7654_RS16660	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J7654_RS16665	COG1181	Belongs to the D-alanine--D-alanine ligase family
J7654_RS16690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J7654_RS16700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J7654_RS16705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J7654_RS16715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J7654_RS16735	COG2001	Belongs to the MraZ family
J7654_RS16750	COG3023	N-Acetylmuramoyl-L-alanine amidase
J7654_RS16755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
J7654_RS16780	COG0154	amidase activity
J7654_RS16790	COG0640	Transcriptional regulator
J7654_RS16805	COG0586	Pfam SNARE associated Golgi protein
J7654_RS16810	COG0784	Response regulator, receiver
J7654_RS16830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J7654_RS16840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J7654_RS16840	COG1116	anion transmembrane transporter activity
J7654_RS16850	COG2267	carboxylic ester hydrolase activity
J7654_RS16855	COG0740	serine-type endopeptidase activity
J7654_RS16885	COG1012	belongs to the aldehyde dehydrogenase family
J7654_RS16900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J7654_RS16905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J7654_RS16905	COG2010	Cytochrome c
J7654_RS16925	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
J7654_RS16930	COG0346	lactoylglutathione lyase activity
J7654_RS16935	COG0400	carboxylic ester hydrolase activity
J7654_RS16940	COG2951	lytic endotransglycosylase activity
J7654_RS16960	COG1304	FMN binding
J7654_RS17020	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J7654_RS17025	COG1278	Cold shock
J7654_RS17045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J7654_RS17055	COG4581	dead DEAH box helicase
J7654_RS17065	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS17070	COG0183	Belongs to the thiolase family
J7654_RS17075	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
J7654_RS17080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J7654_RS17085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J7654_RS17090	COG0142	geranyltranstransferase activity
J7654_RS17110	COG2116	formate transmembrane transporter activity
J7654_RS17115	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
J7654_RS17120	COG0346	lactoylglutathione lyase activity
J7654_RS17130	COG1640	4-alpha-glucanotransferase
J7654_RS17135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J7654_RS17165	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
J7654_RS17170	COG4266	Belongs to the allantoicase family
J7654_RS17180	COG2351	hydroxyisourate hydrolase activity
J7654_RS17190	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J7654_RS17200	COG3845	ABC transporter
J7654_RS17205	COG4603	Belongs to the binding-protein-dependent transport system permease family
J7654_RS17210	COG1079	Belongs to the binding-protein-dependent transport system permease family
J7654_RS17225	COG0402	S-adenosylhomocysteine deaminase activity
J7654_RS17230	COG0366	Alpha amylase catalytic
J7654_RS17235	COG0366	Alpha amylase catalytic
J7654_RS17245	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
J7654_RS17250	COG0830	nickel cation binding
J7654_RS17255	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
J7654_RS17265	COG0804	urea catabolic process
J7654_RS17280	COG0832	Belongs to the urease beta subunit family
J7654_RS17295	COG0831	urea catabolic process
J7654_RS17300	COG0829	nickel cation binding
J7654_RS17325	COG2223	nitrite transmembrane transporter activity
J7654_RS17335	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J7654_RS17345	COG2986	histidine ammonia-lyase
J7654_RS17350	COG1228	amidohydrolase
J7654_RS17355	COG2188	Transcriptional regulator
J7654_RS17365	COG1116	anion transmembrane transporter activity
J7654_RS17400	COG3842	ATPase activity
J7654_RS17405	COG1176	ABC-type spermidine putrescine transport system, permease component I
J7654_RS17415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J7654_RS17420	COG2326	polyphosphate kinase activity
J7654_RS17430	COG3386	PFAM SMP-30 Gluconolaconase
J7654_RS17440	COG0730	response to heat
J7654_RS17450	COG0840	transmembrane signaling receptor activity
J7654_RS17455	COG1217	gtp-binding protein TYPA
J7654_RS17465	COG0339	signal peptide processing
J7654_RS17475	COG2814	Major facilitator Superfamily
J7654_RS17480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J7654_RS17490	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J7654_RS17495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J7654_RS17510	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J7654_RS17520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J7654_RS17525	COG0799	negative regulation of ribosome biogenesis
J7654_RS17530	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J7654_RS17540	COG0793	Belongs to the peptidase S41A family
J7654_RS17545	COG5001	Diguanylate cyclase
J7654_RS17545	COG3300	MHYT domain
J7654_RS17555	COG0494	nUDIX hydrolase
J7654_RS17560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J7654_RS17570	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J7654_RS17575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J7654_RS17585	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J7654_RS17600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J7654_RS17605	COG0783	Belongs to the Dps family
J7654_RS17615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J7654_RS17630	COG1053	succinate dehydrogenase
J7654_RS17640	COG2009	succinate dehydrogenase
J7654_RS17650	COG2199	diguanylate cyclase activity
J7654_RS17655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J7654_RS17660	COG0335	large ribosomal subunit rRNA binding
J7654_RS17670	COG0336	Belongs to the RNA methyltransferase TrmD family
J7654_RS17680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J7654_RS17695	COG1605	Chorismate mutase
J7654_RS17695	COG0287	Prephenate dehydrogenase
J7654_RS17700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J7654_RS17710	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J7654_RS17715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J7654_RS17725	COG0552	protein localization to endoplasmic reticulum
J7654_RS17730	COG1304	FMN binding
J7654_RS17735	COG2917	probably involved in intracellular septation
J7654_RS17750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J7654_RS17760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J7654_RS17765	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J7654_RS17770	COG4133	protoheme IX ABC transporter activity
J7654_RS17775	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J7654_RS17795	COG3300	MHYT domain
J7654_RS17795	COG5001	Diguanylate cyclase
J7654_RS17800	COG1335	isochorismatase
J7654_RS17810	COG0670	Belongs to the BI1 family
J7654_RS17820	COG4181	ATPase activity
J7654_RS17835	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
J7654_RS17840	COG3339	Conserved Protein
J7654_RS17850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J7654_RS17880	COG0137	argininosuccinate synthase activity
J7654_RS17890	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J7654_RS17895	COG1872	DUF167
J7654_RS17915	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
J7654_RS17925	COG2943	transferase activity, transferring hexosyl groups
J7654_RS17940	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J7654_RS17960	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J7654_RS17970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J7654_RS17975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J7654_RS17980	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J7654_RS17995	COG0072	phenylalanine-tRNA ligase activity
J7654_RS17995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J7654_RS18000	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
J7654_RS18005	COG0837	glucose binding
J7654_RS18010	COG1132	(ABC) transporter
J7654_RS18015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J7654_RS18020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J7654_RS18035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J7654_RS18045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J7654_RS18050	COG0606	chelatase, subunit chli
J7654_RS18060	COG0189	ligase activity
J7654_RS18065	COG3158	transport of potassium into the cell
J7654_RS18070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J7654_RS18085	COG0792	nuclease activity
J7654_RS18090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
J7654_RS18095	COG1742	UPF0060 membrane protein
J7654_RS18100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J7654_RS18105	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J7654_RS18110	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J7654_RS18120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J7654_RS18125	COG1028	Short-chain dehydrogenase reductase Sdr
J7654_RS18135	COG1252	NADH dehydrogenase
J7654_RS18145	COG3791	Glutathione-dependent formaldehyde-activating
J7654_RS18150	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
J7654_RS18155	COG0424	maF-like protein
J7654_RS18160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J7654_RS18165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J7654_RS18185	COG0842	Transport permease protein
J7654_RS18190	COG1131	(ABC) transporter
J7654_RS18195	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J7654_RS18210	COG0589	response to stress
J7654_RS18215	COG0668	transmembrane transport
J7654_RS18230	COG0756	dUTP diphosphatase activity
J7654_RS18235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J7654_RS18240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J7654_RS18250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J7654_RS18255	COG0268	Binds directly to 16S ribosomal RNA