locus-tag	class	description
M673_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M673_RS00030	COG0840	transmembrane signaling receptor activity
M673_RS00050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M673_RS00060	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M673_RS00065	COG1522	sequence-specific DNA binding
M673_RS00070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M673_RS00075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_RS00080	COG3706	GGDEF domain
M673_RS00085	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M673_RS00085	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M673_RS00090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M673_RS00095	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M673_RS00100	COG2205	protein histidine kinase activity
M673_RS00105	COG3178	'Phosphotransferase
M673_RS00110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M673_RS00120	COG1074	ATP-dependent DNA helicase activity
M673_RS00155	COG0133	tryptophan synthase activity
M673_RS00190	COG0284	orotidine-5'-phosphate decarboxylase activity
M673_RS00195	COG3920	Histidine kinase
M673_RS00200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M673_RS00200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M673_RS00210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M673_RS00220	COG1393	Belongs to the ArsC family
M673_RS00240	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M673_RS00245	COG0443	Heat shock 70 kDa protein
M673_RS00255	COG0484	heat shock protein binding
M673_RS00260	COG3963	phosphatidate phosphatase activity
M673_RS00265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M673_RS00280	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS00285	COG4134	Bacterial extracellular solute-binding protein
M673_RS00300	COG1643	Atp-dependent helicase
M673_RS00310	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
M673_RS00320	COG0596	Alpha beta hydrolase
M673_RS00325	COG0667	Aldo Keto reductase
M673_RS00335	COG1185	polyribonucleotide nucleotidyltransferase activity
M673_RS00345	COG0840	transmembrane signaling receptor activity
M673_RS00355	COG1785	Belongs to the alkaline phosphatase family
M673_RS00365	COG1136	(ABC) transporter
M673_RS00385	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS00410	COG0668	transmembrane transport
M673_RS00420	COG3706	GGDEF domain
M673_RS00425	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M673_RS00435	COG1280	lysine exporter protein (LysE YggA)
M673_RS00440	COG0756	dUTP diphosphatase activity
M673_RS00445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M673_RS00460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M673_RS00470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M673_RS00475	COG1136	(ABC) transporter
M673_RS00480	COG0577	efflux transmembrane transporter activity
M673_RS00490	COG1234	tRNA 3'-trailer cleavage
M673_RS00505	COG1247	-acetyltransferase
M673_RS00510	COG0443	Heat shock 70 kDa protein
M673_RS00530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M673_RS00535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M673_RS00540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M673_RS00545	COG1116	anion transmembrane transporter activity
M673_RS00550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M673_RS00555	COG2146	nitrite reductase [NAD(P)H] activity
M673_RS00560	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
M673_RS00565	COG0243	molybdopterin cofactor binding
M673_RS00570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M673_RS00570	COG1648	precorrin-2 dehydrogenase activity
M673_RS00600	COG2201	protein-glutamate methylesterase activity
M673_RS00610	COG0835	chemotaxis
M673_RS00615	COG0835	chemotaxis
M673_RS00620	COG0643	Histidine kinase
M673_RS00620	COG2198	Histidine kinase
M673_RS00625	COG0745	RESPONSE REGULATOR receiver
M673_RS00635	COG0840	transmembrane signaling receptor activity
M673_RS00645	COG0745	RESPONSE REGULATOR receiver
M673_RS00650	COG2198	Histidine kinase
M673_RS00650	COG0643	Histidine kinase
M673_RS00655	COG0835	chemotaxis
M673_RS00660	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M673_RS00665	COG2201	protein-glutamate methylesterase activity
M673_RS00670	COG0745	RESPONSE REGULATOR receiver
M673_RS00695	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M673_RS00700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M673_RS00705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M673_RS00710	COG0351	phosphomethylpyrimidine kinase
M673_RS00720	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M673_RS00725	COG4957	zinc ion binding
M673_RS00730	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M673_RS00735	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M673_RS00745	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M673_RS00755	COG1968	undecaprenyl-diphosphatase activity
M673_RS00780	COG2855	membrane
M673_RS00785	COG0583	DNA-binding transcription factor activity
M673_RS00790	COG0583	DNA-binding transcription factor activity
M673_RS00795	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M673_RS00810	COG0747	negative chemotaxis
M673_RS00820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M673_RS00825	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS00830	COG0444	Belongs to the ABC transporter superfamily
M673_RS00835	COG4608	Belongs to the ABC transporter superfamily
M673_RS00850	COG4948	Mandelate Racemase Muconate Lactonizing
M673_RS00855	COG1414	Transcriptional regulator
M673_RS00870	COG4948	Mandelate Racemase Muconate Lactonizing
M673_RS00875	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M673_RS00880	COG3964	amidohydrolase
M673_RS00890	COG1175	transmembrane transport
M673_RS00895	COG0395	ABC-type sugar transport system, permease component
M673_RS00900	COG0656	L-ascorbic acid biosynthetic process
M673_RS00905	COG3842	ATPase activity
M673_RS00925	COG4702	Belongs to the UPF0303 family
M673_RS00950	COG3920	Histidine kinase
M673_RS00950	COG2202	Pas domain
M673_RS00955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M673_RS00965	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M673_RS00970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M673_RS00975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M673_RS00975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M673_RS00990	COG0779	Required for maturation of 30S ribosomal subunits
M673_RS00995	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M673_RS01000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M673_RS01005	COG1396	sequence-specific DNA binding
M673_RS01020	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M673_RS01030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M673_RS01040	COG0456	acetyltransferase
M673_RS01050	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M673_RS01065	COG0180	Tryptophanyl-tRNA synthetase
M673_RS01075	COG0728	peptidoglycan biosynthetic process
M673_RS01080	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M673_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS01090	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M673_RS01110	COG0604	alcohol dehydrogenase
M673_RS01120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M673_RS01125	COG0116	Belongs to the methyltransferase superfamily
M673_RS01125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M673_RS01145	COG0616	signal peptide processing
M673_RS01160	COG1137	ATPase activity
M673_RS01170	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M673_RS01175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M673_RS01185	COG0071	Belongs to the small heat shock protein (HSP20) family
M673_RS01190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M673_RS01195	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M673_RS01215	COG0745	RESPONSE REGULATOR receiver
M673_RS01220	COG2205	protein histidine kinase activity
M673_RS01225	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M673_RS01240	COG2954	triphosphatase activity
M673_RS01250	COG1187	pseudouridine synthase activity
M673_RS01255	COG2391	methyltransferase activity
M673_RS01260	COG0481	GTPase activity
M673_RS01275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M673_RS01285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M673_RS01305	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M673_RS01310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M673_RS01315	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M673_RS01320	COG0799	negative regulation of ribosome biogenesis
M673_RS01325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M673_RS01335	COG0793	Belongs to the peptidase S41A family
M673_RS01360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M673_RS01365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M673_RS01370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M673_RS01375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M673_RS01400	COG0783	Belongs to the Dps family
M673_RS01405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M673_RS01420	COG3309	Virulence-associated protein D
M673_RS01425	COG1053	succinate dehydrogenase
M673_RS01445	COG2199	diguanylate cyclase activity
M673_RS01470	COG0335	large ribosomal subunit rRNA binding
M673_RS01485	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M673_RS01490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M673_RS01500	COG0552	protein localization to endoplasmic reticulum
M673_RS01520	COG3118	belongs to the thioredoxin family
M673_RS01545	COG2814	Major facilitator Superfamily
M673_RS01550	COG0583	DNA-binding transcription factor activity
M673_RS01555	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
M673_RS01555	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
M673_RS01560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M673_RS01575	COG1175	transmembrane transport
M673_RS01580	COG3833	ABC-type maltose transport systems, permease component
M673_RS01585	COG3842	ATPase activity
M673_RS01605	COG1486	melibiose metabolic process
M673_RS01610	COG1609	Transcriptional regulator
M673_RS01610	COG2207	Transcriptional regulator
M673_RS01615	COG1486	melibiose metabolic process
M673_RS01620	COG0747	negative chemotaxis
M673_RS01625	COG0601	transmembrane transport
M673_RS01630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M673_RS01635	COG4172	Belongs to the ABC transporter superfamily
M673_RS01660	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS01665	COG0840	transmembrane signaling receptor activity
M673_RS01670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M673_RS01680	COG1120	ATPase activity
M673_RS01685	COG5001	Diguanylate cyclase
M673_RS01690	COG0326	Molecular chaperone. Has ATPase activity
M673_RS01695	COG1609	Transcriptional regulator
M673_RS01700	COG4774	siderophore transport
M673_RS01715	COG1175	transmembrane transport
M673_RS01745	COG1178	ABC-type Fe3 transport system permease component
M673_RS01750	COG3842	ATPase activity
M673_RS01760	COG0840	transmembrane signaling receptor activity
M673_RS01775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M673_RS01780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M673_RS01785	COG0539	negative regulation of cytoplasmic translation
M673_RS01815	COG2885	chlorophyll binding
M673_RS01825	COG2814	Major facilitator Superfamily
M673_RS01830	COG1960	acyl-CoA dehydrogenase activity
M673_RS01835	COG3938	Belongs to the proline racemase family
M673_RS01845	COG3938	Belongs to the proline racemase family
M673_RS01850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_RS01875	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
M673_RS01880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M673_RS01885	COG1802	Transcriptional regulator
M673_RS01895	COG0318	PFAM AMP-dependent synthetase and ligase
M673_RS01900	COG1473	amidohydrolase
M673_RS01920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M673_RS01925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M673_RS01935	COG0667	Aldo Keto reductase
M673_RS01955	COG0131	Imidazoleglycerol-phosphate dehydratase
M673_RS01965	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M673_RS01970	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M673_RS01980	COG0107	imidazoleglycerol-phosphate synthase activity
M673_RS02000	COG0596	Alpha beta hydrolase
M673_RS02005	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M673_RS02025	COG2197	response regulator
M673_RS02030	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M673_RS02035	COG0477	Major facilitator Superfamily
M673_RS02040	COG0121	glutamine amidotransferase
M673_RS02045	COG1794	racemase activity, acting on amino acids and derivatives
M673_RS02050	COG1522	sequence-specific DNA binding
M673_RS02070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M673_RS02075	COG1396	sequence-specific DNA binding
M673_RS02075	COG3800	Transcriptional regulator
M673_RS02095	COG3030	protein affecting phage T7 exclusion by the F plasmid
M673_RS02100	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M673_RS02115	COG0237	dephospho-CoA kinase activity
M673_RS02130	COG0424	maF-like protein
M673_RS02135	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M673_RS02145	COG1981	membrane
M673_RS02150	COG3265	gluconokinase activity
M673_RS02155	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M673_RS02170	COG1331	Highly conserved protein containing a thioredoxin domain
M673_RS02180	COG1695	Transcriptional regulator
M673_RS02185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M673_RS02190	COG1247	-acetyltransferase
M673_RS02200	COG0445	tRNA wobble uridine modification
M673_RS02225	COG3755	Protein conserved in bacteria
M673_RS02240	COG0495	leucyl-tRNA aminoacylation
M673_RS02245	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M673_RS02250	COG0586	Pfam SNARE associated Golgi protein
M673_RS02260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M673_RS02265	COG3775	system Galactitol-specific IIC component
M673_RS02275	COG3414	Phosphotransferase system galactitol-specific IIB component
M673_RS02295	COG2814	Major facilitator Superfamily
M673_RS02305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M673_RS02325	COG0501	Belongs to the peptidase M48B family
M673_RS02360	COG0138	bifunctional purine biosynthesis protein purh
M673_RS02370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M673_RS02385	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M673_RS02390	COG1704	LemA family
M673_RS02410	COG0288	reversible hydration of carbon dioxide
M673_RS02415	COG2845	Protein of unknown function (DUF459)
M673_RS02420	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M673_RS02425	COG0045	succinate-CoA ligase (ADP-forming) activity
M673_RS02430	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M673_RS02460	COG3706	GGDEF domain
M673_RS02460	COG5001	Diguanylate cyclase
M673_RS02460	COG2203	Gaf domain
M673_RS02460	COG4251	negative regulation of phosphorylation
M673_RS02480	COG1764	response to oxidative stress
M673_RS02490	COG1914	H( )-stimulated, divalent metal cation uptake system
M673_RS02495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M673_RS02500	COG0523	cobalamin synthesis protein
M673_RS02510	COG0473	3-isopropylmalate dehydrogenase activity
M673_RS02515	COG0840	transmembrane signaling receptor activity
M673_RS02525	COG0066	3-isopropylmalate dehydratase activity
M673_RS02530	COG1846	Transcriptional regulator
M673_RS02535	COG1764	response to oxidative stress
M673_RS02575	COG0587	DNA-directed DNA polymerase activity
M673_RS02580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M673_RS02595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M673_RS02595	COG2010	Cytochrome c
M673_RS02600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M673_RS02625	COG2971	BadF BadG BcrA BcrD
M673_RS02640	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M673_RS02645	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M673_RS02650	COG2133	pyrroloquinoline quinone binding
M673_RS02655	COG1120	ATPase activity
M673_RS02665	COG4607	ABC-type enterochelin transport system periplasmic component
M673_RS02720	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M673_RS02725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M673_RS02730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M673_RS02735	COG0424	maF-like protein
M673_RS02740	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M673_RS02765	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M673_RS02770	COG2264	protein methyltransferase activity
M673_RS02785	COG2350	Protein conserved in bacteria
M673_RS02790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M673_RS02795	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M673_RS02800	COG0181	hydroxymethylbilane synthase activity
M673_RS02825	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M673_RS02830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M673_RS02840	COG2851	Citrate transporter
M673_RS02850	COG0840	transmembrane signaling receptor activity
M673_RS02865	COG1872	DUF167
M673_RS02875	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M673_RS02890	COG0604	alcohol dehydrogenase
M673_RS02900	COG1217	gtp-binding protein TYPA
M673_RS02905	COG0339	signal peptide processing
M673_RS02915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M673_RS02920	COG0137	argininosuccinate synthase activity
M673_RS02925	COG0671	phosphoesterase, PA-phosphatase related
M673_RS02960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M673_RS02995	COG4181	ATPase activity
M673_RS03005	COG0670	Belongs to the BI1 family
M673_RS03015	COG3300	MHYT domain
M673_RS03015	COG5001	Diguanylate cyclase
M673_RS03030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M673_RS03035	COG4133	protoheme IX ABC transporter activity
M673_RS03040	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M673_RS03045	COG0454	-acetyltransferase
M673_RS03045	COG0456	acetyltransferase
M673_RS03050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M673_RS03055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M673_RS03065	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M673_RS03075	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M673_RS03095	COG2895	sulfate adenylyltransferase (ATP) activity
M673_RS03100	COG0175	sulfate reduction
M673_RS03105	COG0175	sulfate reduction
M673_RS03115	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M673_RS03125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M673_RS03135	COG1946	Acyl-CoA thioesterase
M673_RS03140	COG0347	Belongs to the P(II) protein family
M673_RS03145	COG0004	ammonium transporteR
M673_RS03155	COG1674	ftsk spoiiie
M673_RS03165	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M673_RS03175	COG0740	serine-type endopeptidase activity
M673_RS03195	COG0596	Alpha beta hydrolase
M673_RS03205	COG4774	siderophore transport
M673_RS03215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M673_RS03225	COG2207	Transcriptional regulator
M673_RS03230	COG0667	Aldo Keto reductase
M673_RS03245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M673_RS03250	COG1132	(ABC) transporter
M673_RS03255	COG0837	glucose binding
M673_RS03270	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M673_RS03275	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
M673_RS03295	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M673_RS03300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M673_RS03305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M673_RS03315	COG0243	molybdopterin cofactor binding
M673_RS03325	COG0745	RESPONSE REGULATOR receiver
M673_RS03340	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M673_RS03350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M673_RS03355	COG0606	chelatase, subunit chli
M673_RS03370	COG0189	ligase activity
M673_RS03380	COG0792	nuclease activity
M673_RS03385	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M673_RS03390	COG1742	UPF0060 membrane protein
M673_RS03395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M673_RS03400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M673_RS03405	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M673_RS03435	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS03440	COG1252	NADH dehydrogenase
M673_RS03475	COG0784	Response regulator, receiver
M673_RS03475	COG4191	Histidine kinase
M673_RS03480	COG3920	Histidine kinase
M673_RS03480	COG2202	Pas domain
M673_RS03485	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS03495	COG1492	cobalamin metabolic process
M673_RS03535	COG2875	Belongs to the precorrin methyltransferase family
M673_RS03540	COG2099	Precorrin-6x reductase
M673_RS03545	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
M673_RS03550	COG1797	cobyrinic acid a,c-diamide synthase activity
M673_RS03605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M673_RS03630	COG3300	MHYT domain
M673_RS03630	COG5001	Diguanylate cyclase
M673_RS03645	COG2189	Belongs to the N(4) N(6)-methyltransferase family
M673_RS03650	COG0583	DNA-binding transcription factor activity
M673_RS03695	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M673_RS03700	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M673_RS03705	COG2080	2 iron, 2 sulfur cluster binding
M673_RS03725	COG0673	inositol 2-dehydrogenase activity
M673_RS03730	COG1129	ABC transporter
M673_RS03735	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_RS03740	COG1879	ABC-type sugar transport system periplasmic component
M673_RS03745	COG0328	RNA-DNA hybrid ribonuclease activity
M673_RS03755	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS03780	COG0583	DNA-binding transcription factor activity
M673_RS03785	COG1733	regulation of RNA biosynthetic process
M673_RS03815	COG3237	CsbD-like
M673_RS03820	COG4191	Histidine kinase
M673_RS03820	COG0784	Response regulator, receiver
M673_RS03835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M673_RS03840	COG0747	negative chemotaxis
M673_RS03845	COG0601	transmembrane transport
M673_RS03870	COG0745	RESPONSE REGULATOR receiver
M673_RS03890	COG0583	DNA-binding transcription factor activity
M673_RS03920	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS03955	COG3293	Transposase
M673_RS03975	COG1136	(ABC) transporter
M673_RS03990	COG4124	Belongs to the glycosyl hydrolase 26 family
M673_RS03990	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M673_RS04015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_RS04025	COG1162	GTPase activity
M673_RS04060	COG1454	alcohol dehydrogenase
M673_RS04065	COG1012	belongs to the aldehyde dehydrogenase family
M673_RS04070	COG0583	DNA-binding transcription factor activity
M673_RS04080	COG2301	Belongs to the HpcH HpaI aldolase family
M673_RS04095	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M673_RS04140	COG2814	Major facilitator Superfamily
M673_RS04155	COG1309	transcriptional regulator
M673_RS04185	COG2207	Transcriptional regulator
M673_RS04200	COG0765	amino acid transport
M673_RS04210	COG1126	abc transporter atp-binding protein
M673_RS04215	COG4948	Mandelate Racemase Muconate Lactonizing
M673_RS04225	COG1063	alcohol dehydrogenase
M673_RS04240	COG2207	Transcriptional regulator
M673_RS04255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M673_RS04260	COG1744	ABC transporter substrate-binding protein PnrA-like
M673_RS04270	COG2900	Belongs to the SlyX family
M673_RS04280	COG3845	ABC transporter
M673_RS04290	COG1079	Belongs to the binding-protein-dependent transport system permease family
M673_RS04295	COG1079	Belongs to the binding-protein-dependent transport system permease family
M673_RS04310	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M673_RS04315	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M673_RS04325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M673_RS04330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M673_RS04335	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M673_RS04370	COG4964	Belongs to the GSP D family
M673_RS04405	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M673_RS04425	COG0494	nUDIX hydrolase
M673_RS04430	COG4172	Belongs to the ABC transporter superfamily
M673_RS04450	COG4239	(ABC) transporter, permease
M673_RS04455	COG4174	ABC transporter (Permease)
M673_RS04460	COG4166	transmembrane transport
M673_RS04465	COG4166	transmembrane transport
M673_RS04470	COG3474	cytochrome
M673_RS04475	COG0077	Prephenate dehydratase
M673_RS04475	COG1605	Chorismate mutase
M673_RS04500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M673_RS04510	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M673_RS04550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M673_RS04560	COG0242	peptide deformylase activity
M673_RS04565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M673_RS04570	COG0101	tRNA pseudouridine synthase activity
M673_RS04580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M673_RS04595	COG2171	N-acyltransferase activity
M673_RS04620	COG0477	Major facilitator Superfamily
M673_RS04625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M673_RS04630	COG4191	Histidine kinase
M673_RS04630	COG0784	Response regulator, receiver
M673_RS04640	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS04650	COG0840	transmembrane signaling receptor activity
M673_RS04655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M673_RS04680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M673_RS04695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M673_RS04705	COG0336	Belongs to the RNA methyltransferase TrmD family
M673_RS04725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M673_RS04740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M673_RS04755	COG2943	transferase activity, transferring hexosyl groups
M673_RS04765	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M673_RS04790	COG1139	Iron-sulfur cluster binding protein
M673_RS04795	COG0247	lactate metabolic process
M673_RS04805	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M673_RS04810	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M673_RS04825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M673_RS04840	COG0489	protein tyrosine kinase activity
M673_RS04840	COG3206	protein involved in exopolysaccharide biosynthesis
M673_RS04880	COG1215	transferase activity, transferring glycosyl groups
M673_RS04905	COG3158	transport of potassium into the cell
M673_RS04915	COG0840	transmembrane signaling receptor activity
M673_RS04920	COG2113	Glycine betaine
M673_RS04930	COG0517	IMP dehydrogenase activity
M673_RS04930	COG4175	Glycine betaine
M673_RS04940	COG0438	transferase activity, transferring glycosyl groups
M673_RS04950	COG2814	Major facilitator Superfamily
M673_RS04955	COG2329	Antibiotic biosynthesis monooxygenase
M673_RS04980	COG0601	transmembrane transport
M673_RS04985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M673_RS04995	COG4608	Belongs to the ABC transporter superfamily
M673_RS05030	COG0330	HflC and HflK could
M673_RS05035	COG0737	Belongs to the 5'-nucleotidase family
M673_RS05040	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M673_RS05055	COG1376	ErfK ybiS ycfS ynhG family protein
M673_RS05065	COG0824	Thioesterase
M673_RS05070	COG5001	Diguanylate cyclase
M673_RS05070	COG3300	MHYT domain
M673_RS05080	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M673_RS05085	COG3781	membrane
M673_RS05090	COG3750	Belongs to the UPF0335 family
M673_RS05105	COG0300	oxidoreductase activity
M673_RS05115	COG1295	ribonuclease BN
M673_RS05130	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M673_RS05145	COG1522	sequence-specific DNA binding
M673_RS05165	COG0829	nickel cation binding
M673_RS05170	COG0831	urea catabolic process
M673_RS05185	COG0832	Belongs to the urease beta subunit family
M673_RS05200	COG0804	urea catabolic process
M673_RS05205	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
M673_RS05210	COG0830	nickel cation binding
M673_RS05215	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M673_RS05225	COG2824	Alkylphosphonate utilization operon protein PhnA
M673_RS05230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M673_RS05235	COG2226	methyltransferase
M673_RS05240	COG4993	Dehydrogenase
M673_RS05265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M673_RS05275	COG3845	ABC transporter
M673_RS05280	COG4603	Belongs to the binding-protein-dependent transport system permease family
M673_RS05285	COG1079	Belongs to the binding-protein-dependent transport system permease family
M673_RS05300	COG0402	S-adenosylhomocysteine deaminase activity
M673_RS05305	COG0179	Fumarylacetoacetate (FAA) hydrolase
M673_RS05310	COG0366	Alpha amylase catalytic
M673_RS05315	COG3281	Trehalose synthase
M673_RS05350	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M673_RS05355	COG1640	4-alpha-glucanotransferase
M673_RS05370	COG0673	inositol 2-dehydrogenase activity
M673_RS05395	COG1196	nuclear chromosome segregation
M673_RS05395	COG0741	lytic transglycosylase activity
M673_RS05395	COG0739	heme binding
M673_RS05405	COG1473	amidohydrolase
M673_RS05410	COG2378	regulation of single-species biofilm formation
M673_RS05415	COG0142	geranyltranstransferase activity
M673_RS05420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M673_RS05425	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M673_RS05435	COG0183	Belongs to the thiolase family
M673_RS05465	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M673_RS05515	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
M673_RS05515	COG2273	Hydrolase Family 16
M673_RS05545	COG2226	methyltransferase
M673_RS05600	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS05605	COG1247	-acetyltransferase
M673_RS05610	COG1982	Orn Lys Arg decarboxylase major
M673_RS05625	COG3842	ATPase activity
M673_RS05640	COG3833	ABC-type maltose transport systems, permease component
M673_RS05655	COG3507	Belongs to the glycosyl hydrolase 43 family
M673_RS05655	COG3693	PFAM glycoside hydrolase, family 10
M673_RS05655	COG2382	esterase
M673_RS05660	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
M673_RS05660	COG2273	Hydrolase Family 16
M673_RS05665	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M673_RS05670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M673_RS05675	COG3206	protein involved in exopolysaccharide biosynthesis
M673_RS05675	COG0489	protein tyrosine kinase activity
M673_RS05710	COG1216	Glycosyl transferase, family 2
M673_RS05710	COG0463	Glycosyl transferase, family 2
M673_RS05715	COG2244	polysaccharide biosynthetic process
M673_RS05720	COG0463	Glycosyl transferase, family 2
M673_RS05735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M673_RS05745	COG1012	belongs to the aldehyde dehydrogenase family
M673_RS05750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_RS05755	COG5383	Protein conserved in bacteria
M673_RS05760	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS05785	COG1733	regulation of RNA biosynthetic process
M673_RS05800	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS05815	COG0300	oxidoreductase activity
M673_RS05850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M673_RS05875	COG3973	AAA domain
M673_RS05940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M673_RS05985	COG3852	Histidine kinase
M673_RS05990	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M673_RS05995	COG0594	ribonuclease P activity
M673_RS06005	COG0110	maltose O-acetyltransferase activity
M673_RS06010	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M673_RS06015	COG1051	belongs to the nudix hydrolase family
M673_RS06020	COG1309	transcriptional regulator
M673_RS06035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M673_RS06040	COG5328	Belongs to the UPF0262 family
M673_RS06045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M673_RS06075	COG3206	protein involved in exopolysaccharide biosynthesis
M673_RS06075	COG0489	protein tyrosine kinase activity
M673_RS06080	COG1653	transport
M673_RS06095	COG3842	ATPase activity
M673_RS06105	COG0129	dihydroxy-acid dehydratase activity
M673_RS06110	COG0363	glucosamine-6-phosphate deaminase activity
M673_RS06115	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M673_RS06120	COG4251	negative regulation of phosphorylation
M673_RS06130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_RS06135	COG0174	glutamine synthetase
M673_RS06155	COG3842	ATPase activity
M673_RS06160	COG1176	ABC-type spermidine putrescine transport system, permease component I
M673_RS06165	COG1177	transmembrane transport
M673_RS06180	COG2205	protein histidine kinase activity
M673_RS06195	COG0025	NhaP-type Na H and K H
M673_RS06200	COG1570	exodeoxyribonuclease VII activity
M673_RS06205	COG0583	DNA-binding transcription factor activity
M673_RS06215	COG1253	flavin adenine dinucleotide binding
M673_RS06245	COG0277	FAD linked oxidase domain protein
M673_RS06255	COG0247	lactate metabolic process
M673_RS06265	COG1376	ErfK ybiS ycfS ynhG family protein
M673_RS06265	COG1388	LysM domain
M673_RS06270	COG1376	ErfK ybiS ycfS ynhG family protein
M673_RS06280	COG2818	Glycosylase
M673_RS06285	COG0124	histidyl-tRNA synthetase
M673_RS06290	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
M673_RS06295	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M673_RS06315	COG0730	response to heat
M673_RS06320	COG0459	protein refolding
M673_RS06340	COG0196	riboflavin kinase activity
M673_RS06345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M673_RS06355	COG0590	tRNA wobble adenosine to inosine editing
M673_RS06360	COG1187	pseudouridine synthase activity
M673_RS06365	COG0742	ribosomal rna small subunit methyltransferase
M673_RS06370	COG0612	Peptidase, M16
M673_RS06375	COG0612	Peptidase, M16
M673_RS06380	COG1752	Esterase of the alpha-beta hydrolase superfamily
M673_RS06395	COG0312	modulator of DNA gyrase
M673_RS06415	COG1519	Transferase
M673_RS06420	COG1663	tetraacyldisaccharide 4'-kinase activity
M673_RS06445	COG0033	Phosphoglucomutase
M673_RS06450	COG0297	glycogen (starch) synthase activity
M673_RS06455	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M673_RS06460	COG0058	SHG alpha-glucan phosphorylase activity
M673_RS06465	COG0166	Belongs to the GPI family
M673_RS06480	COG0729	surface antigen
M673_RS06515	COG1396	sequence-specific DNA binding
M673_RS06520	COG1473	amidohydrolase
M673_RS06525	COG1686	Belongs to the peptidase S11 family
M673_RS06530	COG0523	cobalamin synthesis protein
M673_RS06535	COG0425	Belongs to the sulfur carrier protein TusA family
M673_RS06550	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M673_RS06560	COG0678	peroxiredoxin activity
M673_RS06575	COG0583	DNA-binding transcription factor activity
M673_RS06580	COG2514	catechol 2,3-dioxygenase activity
M673_RS06585	COG0435	Glutathione S-transferase
M673_RS06590	COG0252	asparaginase activity
M673_RS06595	COG3720	iron ion transport
M673_RS06600	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M673_RS06605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M673_RS06610	COG4558	Periplasmic binding protein
M673_RS06620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M673_RS06625	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M673_RS06630	COG1063	alcohol dehydrogenase
M673_RS06640	COG1129	ABC transporter
M673_RS06645	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_RS06660	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M673_RS06665	COG0508	dehydrogenase complex catalyzes the overall conversion of
M673_RS06665	COG0022	dehydrogenase e1 component
M673_RS06670	COG0508	dehydrogenase complex catalyzes the overall conversion of
M673_RS06675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M673_RS06680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M673_RS06690	COG3732	PTS system glucitol sorbitol-specific
M673_RS06730	COG1129	ABC transporter
M673_RS06735	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_RS06760	COG2376	Dihydroxyacetone kinase
M673_RS06770	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M673_RS06775	COG1802	Transcriptional regulator
M673_RS06780	COG2376	Dihydroxyacetone kinase
M673_RS06795	COG0840	transmembrane signaling receptor activity
M673_RS06840	COG0601	transmembrane transport
M673_RS06845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M673_RS06850	COG0444	Belongs to the ABC transporter superfamily
M673_RS06860	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M673_RS06865	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M673_RS06870	COG2080	2 iron, 2 sulfur cluster binding
M673_RS06875	COG4191	Histidine kinase
M673_RS06875	COG0784	Response regulator, receiver
M673_RS06885	COG2207	Transcriptional regulator
M673_RS06895	COG0702	epimerase
M673_RS06900	COG0415	Belongs to the DNA photolyase family
M673_RS06905	COG2066	Belongs to the glutaminase family
M673_RS06920	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
M673_RS06920	COG2273	Hydrolase Family 16
M673_RS06925	COG5001	Diguanylate cyclase
M673_RS06930	COG4521	taurine ABC transporter
M673_RS06935	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M673_RS06940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M673_RS06950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M673_RS06960	COG0626	cystathionine gamma-synthase activity
M673_RS06970	COG1187	pseudouridine synthase activity
M673_RS06985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M673_RS06990	COG4172	Belongs to the ABC transporter superfamily
M673_RS06995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M673_RS07000	COG0601	transmembrane transport
M673_RS07005	COG0747	negative chemotaxis
M673_RS07015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M673_RS07050	COG1174	glycine betaine transport
M673_RS07055	COG1125	glycine betaine transport
M673_RS07060	COG1174	glycine betaine transport
M673_RS07085	COG3119	arylsulfatase activity
M673_RS07100	COG1877	trehalose-phosphatase activity
M673_RS07105	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M673_RS07110	COG0800	Aldolase
M673_RS07115	COG0657	acetylesterase activity
M673_RS07140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M673_RS07145	COG1609	Transcriptional regulator
M673_RS07160	COG0523	cobalamin synthesis protein
M673_RS07170	COG3153	acetyltransferase
M673_RS07180	COG0583	DNA-binding transcription factor activity
M673_RS07195	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
M673_RS07200	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M673_RS07215	COG0693	protein deglycase activity
M673_RS07235	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M673_RS07255	COG1830	Aldolase
M673_RS07265	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M673_RS07290	COG0346	lactoylglutathione lyase activity
M673_RS07295	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M673_RS07305	COG2183	response to ionizing radiation
M673_RS07310	COG3257	ureidoglycine aminohydrolase activity
M673_RS07320	COG0840	transmembrane signaling receptor activity
M673_RS07325	COG3237	CsbD-like
M673_RS07385	COG0243	molybdopterin cofactor binding
M673_RS07405	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M673_RS07410	COG0477	Major facilitator Superfamily
M673_RS07430	COG0753	catalase activity
M673_RS07435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M673_RS07440	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
M673_RS07445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M673_RS07455	COG0519	Catalyzes the synthesis of GMP from XMP
M673_RS07455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M673_RS07460	COG0583	DNA-binding transcription factor activity
M673_RS07495	COG0483	inositol monophosphate 1-phosphatase activity
M673_RS07505	COG0071	Belongs to the small heat shock protein (HSP20) family
M673_RS07520	COG0067	glutamate synthase
M673_RS07520	COG0069	glutamate synthase activity
M673_RS07520	COG0070	glutamate synthase
M673_RS07535	COG2951	lytic endotransglycosylase activity
M673_RS07540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M673_RS07555	COG2202	Pas domain
M673_RS07555	COG3920	Histidine kinase
M673_RS07570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M673_RS07575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M673_RS07610	COG0437	4 iron, 4 sulfur cluster binding
M673_RS07635	COG0673	inositol 2-dehydrogenase activity
M673_RS07640	COG0395	ABC-type sugar transport system, permease component
M673_RS07645	COG1175	transmembrane transport
M673_RS07655	COG1309	transcriptional regulator
M673_RS07660	COG0673	inositol 2-dehydrogenase activity
M673_RS07675	COG0673	inositol 2-dehydrogenase activity
M673_RS07680	COG0400	carboxylic ester hydrolase activity
M673_RS07685	COG0346	lactoylglutathione lyase activity
M673_RS07695	COG3842	ATPase activity
M673_RS07700	COG0395	ABC-type sugar transport system, permease component
M673_RS07705	COG1175	transmembrane transport
M673_RS07710	COG1653	transport
M673_RS07715	COG0584	glycerophosphoryl diester phosphodiesterase
M673_RS07720	COG0483	inositol monophosphate 1-phosphatase activity
M673_RS07725	COG0473	3-isopropylmalate dehydrogenase activity
M673_RS07740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M673_RS07745	COG0601	transmembrane transport
M673_RS07760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_RS07765	COG2186	Transcriptional regulator
M673_RS07775	COG2022	thiamine diphosphate biosynthetic process
M673_RS07775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_RS07800	COG1012	belongs to the aldehyde dehydrogenase family
M673_RS07805	COG1012	belongs to the aldehyde dehydrogenase family
M673_RS07810	COG0456	acetyltransferase
M673_RS07815	COG1522	sequence-specific DNA binding
M673_RS07820	COG5001	Diguanylate cyclase
M673_RS07825	COG0598	Magnesium transport protein CorA
M673_RS07835	COG1376	ErfK ybiS ycfS ynhG family protein
M673_RS07840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M673_RS07845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M673_RS07855	COG2010	Cytochrome c
M673_RS07865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M673_RS07870	COG2111	Na H antiporter
M673_RS07870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M673_RS07875	COG2111	Na H antiporter
M673_RS07880	COG1006	Multisubunit Na H antiporter MnhC subunit
M673_RS07885	COG0651	ATP synthesis coupled electron transport
M673_RS07890	COG1863	multisubunit Na H antiporter MnhE subunit
M673_RS07895	COG2212	antiporter activity
M673_RS07900	COG1320	monovalent cation:proton antiporter activity
M673_RS07915	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M673_RS07915	COG0392	lysyltransferase activity
M673_RS07920	COG0493	'glutamate synthase
M673_RS07930	COG5001	Diguanylate cyclase
M673_RS07935	COG1309	transcriptional regulator
M673_RS07950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M673_RS07955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M673_RS07965	COG1597	lipid kinase activity
M673_RS08000	COG0784	Response regulator, receiver
M673_RS08005	COG2202	Pas domain
M673_RS08005	COG3920	Histidine kinase
M673_RS08035	COG0747	negative chemotaxis
M673_RS08040	COG0601	transmembrane transport
M673_RS08045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M673_RS08050	COG0444	Belongs to the ABC transporter superfamily
M673_RS08055	COG4608	Belongs to the ABC transporter superfamily
M673_RS08065	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M673_RS08065	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M673_RS08065	COG0506	proline dehydrogenase activity
M673_RS08070	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M673_RS08085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M673_RS08085	COG0512	Glutamine amidotransferase of anthranilate synthase
M673_RS08090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M673_RS08100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M673_RS08110	COG3135	benzoate transporter
M673_RS08120	COG0494	nUDIX hydrolase
M673_RS08125	COG0435	Glutathione S-transferase
M673_RS08155	COG0714	Associated with various cellular activities
M673_RS08170	COG0617	tRNA 3'-terminal CCA addition
M673_RS08175	COG0408	coproporphyrinogen oxidase activity
M673_RS08185	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M673_RS08190	COG1132	(ABC) transporter
M673_RS08195	COG1132	(ABC) transporter
M673_RS08210	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M673_RS08210	COG2857	Cytochrome c1
M673_RS08230	COG0012	GTP binding
M673_RS08235	COG0193	aminoacyl-tRNA hydrolase activity
M673_RS08240	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M673_RS08250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M673_RS08255	COG0006	proline dipeptidase activity
M673_RS08260	COG1496	oxidoreductase activity
M673_RS08270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M673_RS08290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M673_RS08300	COG0745	RESPONSE REGULATOR receiver
M673_RS08305	COG1846	Transcriptional regulator
M673_RS08310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M673_RS08315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M673_RS08325	COG1278	Cold shock
M673_RS08345	COG1464	Belongs to the NlpA lipoprotein family
M673_RS08350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M673_RS08355	COG2011	ABC-type metal ion transport system permease component
M673_RS08360	COG0670	Belongs to the BI1 family
M673_RS08385	COG0556	nucleotide-excision repair
M673_RS08405	COG2032	superoxide dismutase activity
M673_RS08415	COG0625	glutathione transferase activity
M673_RS08420	COG0436	Aminotransferase
M673_RS08425	COG0583	DNA-binding transcription factor activity
M673_RS08430	COG0492	ferredoxin-NADP+ reductase activity
M673_RS08435	COG5265	(ABC) transporter
M673_RS08440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M673_RS08450	COG0438	transferase activity, transferring glycosyl groups
M673_RS08465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M673_RS08480	COG0505	Belongs to the CarA family
M673_RS08490	COG0287	Prephenate dehydrogenase
M673_RS08490	COG1605	Chorismate mutase
M673_RS08500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M673_RS08515	COG2968	Membrane
M673_RS08520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M673_RS08525	COG0765	amino acid transport
M673_RS08530	COG1126	abc transporter atp-binding protein
M673_RS08535	COG3706	GGDEF domain
M673_RS08555	COG3920	Histidine kinase
M673_RS08555	COG2202	Pas domain
M673_RS08560	COG4191	Histidine kinase
M673_RS08560	COG0784	Response regulator, receiver
M673_RS08585	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M673_RS08590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M673_RS08600	COG1309	transcriptional regulator
M673_RS08605	COG0477	Major facilitator Superfamily
M673_RS08610	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M673_RS08615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M673_RS08620	COG1845	cytochrome c oxidase, subunit III
M673_RS08625	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M673_RS08665	COG0673	inositol 2-dehydrogenase activity
M673_RS08670	COG0287	Prephenate dehydrogenase
M673_RS08685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M673_RS08695	COG2186	Transcriptional regulator
M673_RS08705	COG3290	protein histidine kinase activity
M673_RS08705	COG0840	transmembrane signaling receptor activity
M673_RS08710	COG3386	PFAM SMP-30 Gluconolaconase
M673_RS08730	COG0489	protein tyrosine kinase activity
M673_RS08730	COG3206	protein involved in exopolysaccharide biosynthesis
M673_RS08755	COG2244	polysaccharide biosynthetic process
M673_RS08770	COG0297	glycogen (starch) synthase activity
M673_RS08795	COG1793	dna ligase
M673_RS08805	COG0123	including yeast histone deacetylase and acetoin utilization protein
M673_RS08820	COG0432	Pfam Uncharacterised protein family UPF0047
M673_RS08825	COG1970	mechanosensitive ion channel activity
M673_RS08830	COG0436	Aminotransferase
M673_RS08840	COG0156	8-amino-7-oxononanoate synthase activity
M673_RS08850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M673_RS08860	COG0747	negative chemotaxis
M673_RS08870	COG1132	(ABC) transporter
M673_RS08875	COG5001	Diguanylate cyclase
M673_RS08875	COG3300	MHYT domain
M673_RS08880	COG4774	siderophore transport
M673_RS08885	COG0039	L-malate dehydrogenase activity
M673_RS08895	COG0300	oxidoreductase activity
M673_RS08900	COG1686	Belongs to the peptidase S11 family
M673_RS08905	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS08910	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M673_RS08930	COG0671	phosphoesterase, PA-phosphatase related
M673_RS08940	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_RS08945	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_RS08950	COG1129	ABC transporter
M673_RS08955	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS08960	COG1063	alcohol dehydrogenase
M673_RS08975	COG3254	rhamnose metabolic process
M673_RS08980	COG1349	DNA-binding transcription factor activity
M673_RS08985	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS08985	COG3347	Dehydrogenase
M673_RS08990	COG4952	isomerase
M673_RS09015	COG0534	Mate efflux family protein
M673_RS09030	COG2017	converts alpha-aldose to the beta-anomer
M673_RS09035	COG0129	dihydroxy-acid dehydratase activity
M673_RS09040	COG3386	PFAM SMP-30 Gluconolaconase
M673_RS09045	COG3734	2-keto-3-deoxy-galactonokinase
M673_RS09050	COG0800	Aldolase
M673_RS09055	COG4213	ABC transporter substrate-binding protein
M673_RS09060	COG4213	ABC transporter substrate-binding protein
M673_RS09070	COG4214	carbohydrate transport
M673_RS09095	COG1012	belongs to the aldehyde dehydrogenase family
M673_RS09115	COG0247	lactate metabolic process
M673_RS09115	COG2181	nitrate reductase activity
M673_RS09120	COG0446	pyridine nucleotide-disulphide oxidoreductase
M673_RS09120	COG1902	pentaerythritol trinitrate reductase activity
M673_RS09130	COG1017	nitric oxide dioxygenase activity
M673_RS09130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M673_RS09145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M673_RS09145	COG0446	pyridine nucleotide-disulphide oxidoreductase
M673_RS09155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_RS09160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M673_RS09160	COG4651	solute:proton antiporter activity
M673_RS09175	COG2022	thiamine diphosphate biosynthetic process
M673_RS09190	COG2267	carboxylic ester hydrolase activity
M673_RS09215	COG0784	Response regulator, receiver
M673_RS09220	COG0586	Pfam SNARE associated Golgi protein
M673_RS09235	COG1720	tRNA m6t6A37 methyltransferase activity
M673_RS09240	COG0640	Transcriptional regulator
M673_RS09265	COG2321	neutral zinc metallopeptidase
M673_RS09270	COG0751	glycine-tRNA ligase activity
M673_RS09275	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M673_RS09290	COG0009	L-threonylcarbamoyladenylate synthase
M673_RS09310	COG0151	Belongs to the GarS family
M673_RS09315	COG1960	acyl-CoA dehydrogenase activity
M673_RS09320	COG0183	Belongs to the thiolase family
M673_RS09325	COG1250	3-hydroxyacyl-CoA dehydrogenase
M673_RS09325	COG1024	Enoyl-CoA hydratase
M673_RS09335	COG1960	acyl-CoA dehydrogenase activity
M673_RS09340	COG1024	Enoyl-CoA hydratase
M673_RS09350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M673_RS09360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M673_RS09365	COG1722	exodeoxyribonuclease VII activity
M673_RS09370	COG0123	including yeast histone deacetylase and acetoin utilization protein
M673_RS09385	COG0406	alpha-ribazole phosphatase activity
M673_RS09390	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M673_RS09395	COG0484	heat shock protein binding
M673_RS09405	COG0259	pyridoxamine-phosphate oxidase activity
M673_RS09410	COG0312	modulator of DNA gyrase
M673_RS09425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M673_RS09430	COG0109	protoheme IX farnesyltransferase activity
M673_RS09440	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M673_RS09455	COG3346	SURF1 family
M673_RS09460	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M673_RS09465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M673_RS09470	COG0328	RNA-DNA hybrid ribonuclease activity
M673_RS09485	COG1678	Uncharacterized ACR, COG1678
M673_RS09500	COG0612	Peptidase, M16
M673_RS09515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M673_RS09520	COG2189	Belongs to the N(4) N(6)-methyltransferase family
M673_RS09545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M673_RS09550	COG0574	Belongs to the PEP-utilizing enzyme family
M673_RS09550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M673_RS09560	COG0318	PFAM AMP-dependent synthetase and ligase
M673_RS09570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M673_RS09575	COG1054	Belongs to the UPF0176 family
M673_RS09585	COG0803	Belongs to the bacterial solute-binding protein 9 family
M673_RS09610	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M673_RS09620	COG4208	sulfate ABC transporter
M673_RS09625	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M673_RS09640	COG0784	Response regulator, receiver
M673_RS09640	COG5002	protein histidine kinase activity
M673_RS09640	COG2198	Histidine kinase
M673_RS09660	COG0411	ABC transporter
M673_RS09670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M673_RS09680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M673_RS09685	COG0668	transmembrane transport
M673_RS09715	COG0656	L-ascorbic acid biosynthetic process
M673_RS09730	COG1522	sequence-specific DNA binding
M673_RS09740	COG1960	acyl-CoA dehydrogenase activity
M673_RS09745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M673_RS09760	COG1024	Enoyl-CoA hydratase
M673_RS09765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M673_RS09770	COG1285	pathogenesis
M673_RS09790	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M673_RS09810	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M673_RS09865	COG3293	Transposase
M673_RS09900	COG1215	transferase activity, transferring glycosyl groups
M673_RS09910	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M673_RS09935	COG1309	transcriptional regulator
M673_RS09945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M673_RS09980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M673_RS09995	COG0546	phosphoglycolate phosphatase activity
M673_RS10000	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M673_RS10020	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M673_RS10035	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
M673_RS10035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M673_RS10040	COG0280	phosphate acetyltransferase
M673_RS10040	COG0281	malic enzyme
M673_RS10050	COG2814	Major facilitator Superfamily
M673_RS10055	COG4948	Mandelate Racemase Muconate Lactonizing
M673_RS10060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M673_RS10065	COG1127	ABC transporter
M673_RS10075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M673_RS10075	COG3218	ABC-type transport auxiliary lipoprotein component
M673_RS10090	COG0633	Ferredoxin
M673_RS10100	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M673_RS10105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M673_RS10115	COG3768	UPF0283 membrane protein
M673_RS10120	COG3106	COG3106 Predicted ATPase
M673_RS10145	COG2313	pseudouridylate synthase activity
M673_RS10150	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M673_RS10150	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M673_RS10160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M673_RS10175	COG0538	isocitrate dehydrogenase activity
M673_RS10180	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
M673_RS10185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M673_RS10195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M673_RS10200	COG0037	tRNA processing
M673_RS10205	COG0483	inositol monophosphate 1-phosphatase activity
M673_RS10210	COG2814	Major facilitator Superfamily
M673_RS10215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M673_RS10225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M673_RS10240	COG0047	phosphoribosylformylglycinamidine synthase activity
M673_RS10245	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M673_RS10250	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M673_RS10265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M673_RS10275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M673_RS10280	COG3191	aminopeptidase activity
M673_RS10320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M673_RS10340	COG3608	succinylglutamate desuccinylase aspartoacylase
M673_RS10340	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M673_RS10345	COG2068	MobA-Related Protein
M673_RS10355	COG2003	Belongs to the UPF0758 family
M673_RS10360	COG0024	Methionine aminopeptidase
M673_RS10365	COG3243	poly(R)-hydroxyalkanoic acid synthase
M673_RS10375	COG0436	Aminotransferase
M673_RS10385	COG1494	fructose-1,6-bisphosphatase
M673_RS10390	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M673_RS10480	COG1278	Cold shock
M673_RS10510	COG0626	cystathionine gamma-synthase activity
M673_RS10515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M673_RS10520	COG4597	amino acid ABC transporter
M673_RS10525	COG0765	amino acid transport
M673_RS10530	COG1126	abc transporter atp-binding protein
M673_RS10535	COG0628	permease
M673_RS10555	COG0596	Alpha beta hydrolase
M673_RS10585	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M673_RS10590	COG1752	Esterase of the alpha-beta hydrolase superfamily
M673_RS10595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M673_RS10600	COG0302	gtp cyclohydrolase
M673_RS10615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M673_RS10630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M673_RS10640	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M673_RS10645	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M673_RS10670	COG0785	Cytochrome C biogenesis protein
M673_RS10675	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M673_RS10680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M673_RS10695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M673_RS10700	COG4166	transmembrane transport
M673_RS10715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M673_RS10720	COG1183	phosphatidylcholine synthase activity
M673_RS10740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M673_RS10755	COG0656	L-ascorbic acid biosynthetic process
M673_RS10760	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M673_RS10785	COG1686	Belongs to the peptidase S11 family
M673_RS10795	COG0463	Glycosyl transferase, family 2
M673_RS10810	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M673_RS10830	COG0537	adenosine 5'-monophosphoramidase activity
M673_RS10855	COG0052	Belongs to the universal ribosomal protein uS2 family
M673_RS10860	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M673_RS10865	COG0528	UMP kinase activity
M673_RS10870	COG0233	cytoplasmic translational termination
M673_RS10875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M673_RS10885	COG0750	zinc metalloprotease
M673_RS10890	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M673_RS10895	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M673_RS10900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M673_RS10905	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M673_RS10915	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M673_RS10920	COG0372	Belongs to the citrate synthase family
M673_RS10930	COG0658	competence protein
M673_RS10930	COG2333	competence protein COMEC
M673_RS10935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M673_RS10940	COG0303	'Molybdopterin
M673_RS10945	COG0315	cyclic pyranopterin monophosphate synthase activity
M673_RS10950	COG0134	indole-3-glycerol-phosphate synthase activity
M673_RS10955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M673_RS10965	COG0149	triose-phosphate isomerase activity
M673_RS10975	COG0504	CTP synthase activity
M673_RS10985	COG0148	phosphopyruvate hydratase activity
M673_RS10990	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M673_RS10995	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M673_RS11000	COG0508	dehydrogenase complex catalyzes the overall conversion of
M673_RS11000	COG0022	dehydrogenase e1 component
M673_RS11005	COG0508	dehydrogenase complex catalyzes the overall conversion of
M673_RS11015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M673_RS11030	COG2867	negative regulation of translational initiation
M673_RS11035	COG1546	Belongs to the CinA family
M673_RS11040	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M673_RS11040	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M673_RS11050	COG3852	Histidine kinase
M673_RS11055	COG2204	response regulator
M673_RS11060	COG5000	phosphorelay sensor kinase activity
M673_RS11065	COG2204	response regulator
M673_RS11070	COG0569	domain protein
M673_RS11080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M673_RS11085	COG3956	TIGRFAM MazG family protein
M673_RS11090	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M673_RS11090	COG0321	lipoyl(octanoyl) transferase activity
M673_RS11095	COG0084	hydrolase, TatD family'
M673_RS11110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M673_RS11115	COG1686	Belongs to the peptidase S11 family
M673_RS11125	COG0343	queuine tRNA-ribosyltransferase activity
M673_RS11130	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M673_RS11145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M673_RS11150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M673_RS11155	COG2095	MarC family integral membrane protein
M673_RS11165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M673_RS11170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M673_RS11170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M673_RS11175	COG0347	Belongs to the P(II) protein family
M673_RS11180	COG0174	glutamine synthetase
M673_RS11190	COG0187	DNA topoisomerase II activity
M673_RS11205	COG0316	Belongs to the HesB IscA family
M673_RS11210	COG2151	metal-sulfur cluster biosynthetic enzyme
M673_RS11215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M673_RS11220	COG0719	Fe-S assembly protein
M673_RS11225	COG0396	ATPase activity
M673_RS11230	COG0719	Fe-S assembly protein
M673_RS11240	COG2945	thiolester hydrolase activity
M673_RS11245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M673_RS11255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M673_RS11260	COG2833	Protein of unknown function (DUF455)
M673_RS11265	COG0741	lytic transglycosylase activity
M673_RS11265	COG1196	nuclear chromosome segregation
M673_RS11265	COG0739	heme binding
M673_RS11275	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M673_RS11280	COG0860	N-Acetylmuramoyl-L-alanine amidase
M673_RS11280	COG1388	LysM domain
M673_RS11285	COG1530	ribonuclease E activity
M673_RS11290	COG0436	Aminotransferase
M673_RS11305	COG0511	ligase activity, forming carbon-carbon bonds
M673_RS11310	COG0439	Biotin carboxylase
M673_RS11315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M673_RS11320	COG4765	Protein conserved in bacteria
M673_RS11330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M673_RS11345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M673_RS11350	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M673_RS11355	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M673_RS11375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M673_RS11380	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M673_RS11385	COG0758	DNA mediated transformation
M673_RS11390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M673_RS11395	COG0557	exoribonuclease II activity
M673_RS11405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M673_RS11445	COG1136	(ABC) transporter
M673_RS11455	COG0442	prolyl-tRNA aminoacylation
M673_RS11475	COG1007	ATP synthesis coupled electron transport
M673_RS11490	COG0713	ATP synthesis coupled electron transport
M673_RS11500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M673_RS11505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M673_RS11515	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M673_RS11520	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M673_RS11525	COG0649	NAD binding
M673_RS11535	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M673_RS11540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M673_RS11545	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M673_RS11565	COG0776	regulation of translation
M673_RS11570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M673_RS11575	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M673_RS11580	COG0740	serine-type endopeptidase activity
M673_RS11585	COG0544	peptidyl-prolyl cis-trans isomerase activity
M673_RS11595	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M673_RS11620	COG1862	Preprotein translocase
M673_RS11630	COG0739	heme binding
M673_RS11630	COG1388	LysM domain
M673_RS11635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M673_RS11640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M673_RS11650	COG0805	protein transport
M673_RS11655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M673_RS11660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M673_RS11665	COG1472	Belongs to the glycosyl hydrolase 3 family
M673_RS11675	COG0018	arginyl-trna synthetase
M673_RS11685	COG0316	Belongs to the HesB IscA family
M673_RS11695	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
M673_RS11720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M673_RS11740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M673_RS11750	COG2897	thiosulfate sulfurtransferase activity
M673_RS11760	COG0737	Belongs to the 5'-nucleotidase family
M673_RS11770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M673_RS11775	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M673_RS11790	COG0655	NAD(P)H dehydrogenase (quinone) activity
M673_RS11795	COG1058	Belongs to the CinA family
M673_RS11795	COG1546	Belongs to the CinA family
M673_RS11800	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M673_RS11805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M673_RS11820	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_RS11830	COG3706	GGDEF domain
M673_RS11840	COG1760	l-serine dehydratase
M673_RS11865	COG0625	glutathione transferase activity
M673_RS11870	COG3739	integral membrane protein
M673_RS11885	COG3842	ATPase activity
M673_RS11895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_RS11905	COG1176	ABC-type spermidine putrescine transport system, permease component I
M673_RS11920	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS11935	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M673_RS11945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M673_RS11965	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M673_RS11970	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
M673_RS11975	COG2205	protein histidine kinase activity
M673_RS11980	COG0745	RESPONSE REGULATOR receiver
M673_RS11995	COG2847	Copper chaperone PCu(A)C
M673_RS12005	COG1999	signal sequence binding
M673_RS12010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M673_RS12015	COG0697	spore germination
M673_RS12025	COG1596	polysaccharide export
M673_RS12050	COG4191	Histidine kinase
M673_RS12050	COG0784	Response regulator, receiver
M673_RS12060	COG0784	Response regulator, receiver
M673_RS12095	COG3772	lysozyme
M673_RS12210	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M673_RS12215	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
M673_RS12240	COG3750	Belongs to the UPF0335 family
M673_RS12430	COG3387	PFAM Glycoside hydrolase 15-related
M673_RS12445	COG0776	regulation of translation
M673_RS12455	COG0416	fatty acid biosynthetic process
M673_RS12475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M673_RS12490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M673_RS12490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M673_RS12495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M673_RS12500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M673_RS12520	COG0113	porphobilinogen synthase activity
M673_RS12530	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M673_RS12535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M673_RS12550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M673_RS12555	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M673_RS12565	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M673_RS12575	COG0628	permease
M673_RS12580	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M673_RS12585	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M673_RS12590	COG0243	molybdopterin cofactor binding
M673_RS12595	COG1902	pentaerythritol trinitrate reductase activity
M673_RS12600	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M673_RS12610	COG0625	glutathione transferase activity
M673_RS12620	COG0322	excinuclease ABC activity
M673_RS12625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M673_RS12635	COG0314	molybdopterin synthase activity
M673_RS12640	COG0105	UTP biosynthetic process
M673_RS12655	COG0488	(ABC) transporter
M673_RS12670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M673_RS12685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M673_RS12690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M673_RS12695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M673_RS12700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M673_RS12705	COG0194	GDP metabolic process
M673_RS12710	COG1561	YicC-like family, N-terminal region
M673_RS12715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M673_RS12720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M673_RS12735	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M673_RS12740	COG0360	Binds together with S18 to 16S ribosomal RNA
M673_RS12755	COG0359	binds to the 23S rRNA
M673_RS12760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M673_RS12770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M673_RS12785	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M673_RS12790	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS12800	COG1183	phosphatidylcholine synthase activity
M673_RS12805	COG0688	phosphatidylethanolamine metabolic process
M673_RS12810	COG5265	(ABC) transporter
M673_RS12830	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M673_RS12840	COG1959	2 iron, 2 sulfur cluster binding
M673_RS12885	COG1268	BioY protein
M673_RS12890	COG1122	ATPase activity
M673_RS12895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M673_RS12905	COG2962	Rard protein
M673_RS12920	COG0215	cysteine-tRNA ligase activity
M673_RS12935	COG1363	Peptidase, m42
M673_RS12965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M673_RS12975	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
M673_RS12985	COG1381	Involved in DNA repair and RecF pathway recombination
M673_RS13005	COG0736	holo-[acyl-carrier-protein] synthase activity
M673_RS13035	COG1573	uracil-dna glycosylase
M673_RS13045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M673_RS13050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M673_RS13055	COG0741	lytic transglycosylase activity
M673_RS13065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M673_RS13070	COG1349	DNA-binding transcription factor activity
M673_RS13075	COG1070	Carbohydrate kinase
M673_RS13080	COG1879	ABC-type sugar transport system periplasmic component
M673_RS13085	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_RS13090	COG1129	ABC transporter
M673_RS13130	COG0321	lipoyl(octanoyl) transferase activity
M673_RS13135	COG1671	Belongs to the UPF0178 family
M673_RS13145	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M673_RS13155	COG0546	phosphoglycolate phosphatase activity
M673_RS13165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M673_RS13170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M673_RS13185	COG0203	ribosomal protein L17
M673_RS13195	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M673_RS13200	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M673_RS13205	COG0563	adenylate kinase activity
M673_RS13215	COG0200	Binds to the 23S rRNA
M673_RS13225	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M673_RS13230	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M673_RS13240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M673_RS13245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M673_RS13250	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M673_RS13255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M673_RS13260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M673_RS13265	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M673_RS13275	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M673_RS13280	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M673_RS13285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M673_RS13290	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M673_RS13295	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M673_RS13300	COG0089	rRNA binding
M673_RS13305	COG0088	Forms part of the polypeptide exit tunnel
M673_RS13310	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M673_RS13320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M673_RS13325	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M673_RS13330	COG0049	tRNA binding
M673_RS13335	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M673_RS13340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M673_RS13345	COG0085	RNA polymerase activity
M673_RS13350	COG0222	ribosome binding
M673_RS13355	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M673_RS13360	COG0081	regulation of translation
M673_RS13365	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M673_RS13395	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M673_RS13410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M673_RS13425	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M673_RS13430	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M673_RS13435	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M673_RS13460	COG4149	molybdate abc transporter
M673_RS13465	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M673_RS13500	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M673_RS13510	COG1335	isochorismatase
M673_RS13525	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M673_RS13530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M673_RS13540	COG2124	cytochrome p450
M673_RS13550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M673_RS13555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M673_RS13560	COG0010	Belongs to the arginase family
M673_RS13565	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M673_RS13570	COG1612	heme a metabolic process
M673_RS13585	COG1596	polysaccharide export
M673_RS13595	COG0251	oxidation-reduction process
M673_RS13600	COG1732	Glycine betaine
M673_RS13605	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M673_RS13610	COG2894	cell division
M673_RS13615	COG0850	regulation of cytokinetic process
M673_RS13640	COG0438	transferase activity, transferring glycosyl groups
M673_RS13655	COG1091	dTDP-4-dehydrorhamnose reductase activity
M673_RS13660	COG1088	dTDP-glucose 4,6-dehydratase activity
M673_RS13665	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M673_RS13685	COG2308	Evidence 4 Homologs of previously reported genes of
M673_RS13705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M673_RS13720	COG0697	spore germination
M673_RS13725	COG0746	molybdenum cofactor guanylyltransferase activity
M673_RS13730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M673_RS13745	COG2084	Dehydrogenase
M673_RS13750	COG1522	sequence-specific DNA binding
M673_RS13755	COG1573	uracil-dna glycosylase
M673_RS13760	COG2202	Pas domain
M673_RS13760	COG2205	protein histidine kinase activity
M673_RS13770	COG3577	Aspartyl protease
M673_RS13775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M673_RS13780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M673_RS13790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M673_RS13805	COG5001	Diguanylate cyclase
M673_RS13810	COG0784	Response regulator, receiver
M673_RS13835	COG1088	dTDP-glucose 4,6-dehydratase activity
M673_RS13850	COG0546	phosphoglycolate phosphatase activity
M673_RS13850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M673_RS13870	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M673_RS13880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M673_RS13895	COG0440	acetolactate synthase activity
M673_RS13900	COG0028	Belongs to the TPP enzyme family
M673_RS13915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M673_RS13920	COG0560	Phosphoserine phosphatase
M673_RS13935	COG0330	HflC and HflK could
M673_RS13940	COG0330	HflC and HflK could
M673_RS13950	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
M673_RS13955	COG5000	phosphorelay sensor kinase activity
M673_RS13985	COG0210	DNA helicase
M673_RS14015	COG0006	proline dipeptidase activity
M673_RS14020	COG1960	acyl-CoA dehydrogenase activity
M673_RS14025	COG0183	Belongs to the thiolase family
M673_RS14035	COG1250	3-hydroxyacyl-CoA dehydrogenase
M673_RS14035	COG1024	Enoyl-CoA hydratase
M673_RS14040	COG1295	ribonuclease BN
M673_RS14055	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
M673_RS14060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M673_RS14080	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M673_RS14085	COG0861	Integral membrane protein TerC family
M673_RS14090	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M673_RS14095	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M673_RS14095	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M673_RS14105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M673_RS14130	COG0625	glutathione transferase activity
M673_RS14135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M673_RS14145	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M673_RS14170	COG0308	aminopeptidase N
M673_RS14175	COG2205	protein histidine kinase activity
M673_RS14175	COG2202	Pas domain
M673_RS14180	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M673_RS14185	COG2205	protein histidine kinase activity
M673_RS14195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M673_RS14200	COG3088	subunit of a heme lyase
M673_RS14205	COG1138	Cytochrome C-type biogenesis protein
M673_RS14210	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M673_RS14215	COG4235	cytochrome complex assembly
M673_RS14320	COG4695	Portal protein
M673_RS14335	COG2983	Belongs to the UPF0260 family
M673_RS14345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M673_RS14380	COG2205	protein histidine kinase activity
M673_RS14390	COG2166	iron-sulfur cluster assembly
M673_RS14420	COG1064	alcohol dehydrogenase
M673_RS14425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M673_RS14435	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M673_RS14440	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M673_RS14445	COG2080	2 iron, 2 sulfur cluster binding
M673_RS14450	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M673_RS14460	COG0697	spore germination
M673_RS14465	COG2094	Belongs to the DNA glycosylase MPG family
M673_RS14475	COG0673	inositol 2-dehydrogenase activity
M673_RS14480	COG0482	sulfurtransferase activity
M673_RS14495	COG0745	RESPONSE REGULATOR receiver
M673_RS14535	COG4191	Histidine kinase
M673_RS14535	COG0784	Response regulator, receiver
M673_RS14555	COG0564	pseudouridine synthase activity
M673_RS14560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M673_RS14565	COG0514	ATP-dependent DNA helicase (RecQ)
M673_RS14575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M673_RS14585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M673_RS14605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M673_RS14610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M673_RS14615	COG0037	tRNA processing
M673_RS14625	COG2885	chlorophyll binding
M673_RS14630	COG0823	Involved in the tonB-independent uptake of proteins
M673_RS14650	COG0824	Thioesterase
M673_RS14660	COG0217	transcriptional regulatory protein
M673_RS14670	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M673_RS14690	COG2255	four-way junction helicase activity
M673_RS14700	COG1692	metallophosphoesterase
M673_RS14705	COG0625	glutathione transferase activity
M673_RS14710	COG2340	Cysteine-rich secretory protein family
M673_RS14715	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M673_RS14730	COG0778	Nitroreductase
M673_RS14755	COG0126	phosphoglycerate kinase activity
M673_RS14765	COG1132	(ABC) transporter
M673_RS14770	COG1793	dna ligase
M673_RS14770	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M673_RS14790	COG1201	RNA secondary structure unwinding
M673_RS14800	COG0659	secondary active sulfate transmembrane transporter activity
M673_RS14820	COG0730	response to heat
M673_RS14840	COG2264	protein methyltransferase activity
M673_RS14845	COG1999	signal sequence binding
M673_RS14855	COG2814	Major facilitator Superfamily
M673_RS14880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M673_RS14890	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M673_RS14900	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M673_RS14905	COG0849	cell division
M673_RS14910	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M673_RS14915	COG1181	Belongs to the D-alanine--D-alanine ligase family
M673_RS14925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M673_RS14930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M673_RS14940	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M673_RS14945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M673_RS14955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M673_RS14970	COG0275	rRNA processing
M673_RS14975	COG2001	Belongs to the MraZ family
M673_RS14990	COG3023	N-Acetylmuramoyl-L-alanine amidase
M673_RS15015	COG0752	glycyl-tRNA synthetase alpha subunit
M673_RS15040	COG0142	geranyltranstransferase activity
M673_RS15050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M673_RS15055	COG0521	Mo-molybdopterin cofactor biosynthetic process
M673_RS15070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M673_RS15075	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M673_RS15080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M673_RS15085	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M673_RS15090	COG0356	it plays a direct role in the translocation of protons across the membrane
M673_RS15105	COG1160	GTP binding
M673_RS15145	COG1684	flagellar biosynthetic protein fliR
M673_RS15150	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M673_RS15155	COG4794	Type iii secretion
M673_RS15160	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M673_RS15165	COG5443	negative regulation of bacterial-type flagellum assembly
M673_RS15170	COG5442	Flagellar protein FlaF
M673_RS15180	COG1749	Flagellar hook protein flgE
M673_RS15205	COG1360	Flagellar Motor Protein
M673_RS15215	COG1766	The M ring may be actively involved in energy transduction
M673_RS15225	COG2433	Pfam Transposase IS66
M673_RS15230	COG3436	PFAM IS66 Orf2 family protein
M673_RS15235	COG2963	transposase activity
M673_RS15240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M673_RS15245	COG1338	Plays a role in the flagellum-specific transport system
M673_RS15255	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M673_RS15265	COG1706	bacterial-type flagellum-dependent cell motility
M673_RS15270	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
M673_RS15275	COG4786	Flagellar basal body rod
M673_RS15280	COG1677	Flagellar hook-basal body complex protein FliE
M673_RS15285	COG1558	bacterial-type flagellum-dependent cell motility
M673_RS15290	COG1815	bacterial-type flagellum-dependent cell motility
M673_RS15300	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M673_RS15305	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M673_RS15310	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M673_RS15325	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M673_RS15330	COG4786	Flagellar basal body rod
M673_RS15335	COG1157	protein secretion by the type III secretion system
M673_RS15350	COG0488	(ABC) transporter
M673_RS15355	COG2354	Protein conserved in bacteria
M673_RS15360	COG1686	Belongs to the peptidase S11 family
M673_RS15370	COG3920	Histidine kinase
M673_RS15370	COG2202	Pas domain
M673_RS15375	COG0513	Belongs to the DEAD box helicase family
M673_RS15395	COG2010	Cytochrome c
M673_RS15395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M673_RS15400	COG2080	2 iron, 2 sulfur cluster binding
M673_RS15405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M673_RS15405	COG2010	Cytochrome c
M673_RS15410	COG1301	dicarboxylic acid transport
M673_RS15415	COG4191	Histidine kinase
M673_RS15420	COG2204	response regulator
M673_RS15445	COG3416	Protein conserved in bacteria
M673_RS15450	COG0531	amino acid
M673_RS15455	COG0546	phosphoglycolate phosphatase activity
M673_RS15465	COG0367	asparagine synthase
M673_RS15470	COG0456	acetyltransferase
M673_RS15475	COG1363	Peptidase, m42
M673_RS15480	COG0840	transmembrane signaling receptor activity
M673_RS15480	COG3290	protein histidine kinase activity
M673_RS15530	COG2967	ApaG domain
M673_RS15545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M673_RS15560	COG0745	RESPONSE REGULATOR receiver
M673_RS15565	COG0704	Plays a role in the regulation of phosphate uptake
M673_RS15570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M673_RS15580	COG0573	inorganic phosphate transmembrane transporter activity
M673_RS15600	COG3387	PFAM Glycoside hydrolase 15-related
M673_RS15615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M673_RS15615	COG0604	alcohol dehydrogenase
M673_RS15615	COG3321	synthase
M673_RS15615	COG4221	oxidoreductase activity
M673_RS15630	COG1132	(ABC) transporter
M673_RS15645	COG0483	inositol monophosphate 1-phosphatase activity
M673_RS15650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M673_RS15670	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M673_RS15675	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M673_RS15680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M673_RS15685	COG0457	Tetratricopeptide repeat
M673_RS15690	COG0469	pyruvate kinase activity
M673_RS15705	COG3750	Belongs to the UPF0335 family
M673_RS15710	COG4957	zinc ion binding
M673_RS15735	COG5310	Homospermidine synthase
M673_RS15750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M673_RS15755	COG0840	transmembrane signaling receptor activity
M673_RS15765	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M673_RS15775	COG1509	lysine 2,3-aminomutase activity
M673_RS15800	COG1278	Cold shock
M673_RS15830	COG1196	nuclear chromosome segregation
M673_RS15830	COG3264	Mechanosensitive ion channel
M673_RS15840	COG2353	YceI-like domain
M673_RS15845	COG0697	spore germination
M673_RS15855	COG2721	sulfolactate sulfo-lyase activity
M673_RS15865	COG4948	Mandelate Racemase Muconate Lactonizing
M673_RS15875	COG1028	Short-chain dehydrogenase reductase Sdr
M673_RS15890	COG1129	ABC transporter
M673_RS15895	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_RS15910	COG1063	alcohol dehydrogenase
M673_RS15915	COG1725	Transcriptional regulator
M673_RS15920	COG0626	cystathionine gamma-synthase activity
M673_RS15935	COG0395	ABC-type sugar transport system, permease component
M673_RS15940	COG3842	ATPase activity
M673_RS15945	COG3142	Participates in the control of copper homeostasis
M673_RS15950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M673_RS15955	COG0395	ABC-type sugar transport system, permease component
M673_RS16015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M673_RS16025	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M673_RS16030	COG1196	nuclear chromosome segregation
M673_RS16030	COG0741	lytic transglycosylase activity
M673_RS16030	COG0739	heme binding
M673_RS16035	COG0667	Aldo Keto reductase
M673_RS16045	COG1376	ErfK ybiS ycfS ynhG family protein
M673_RS16050	COG0656	L-ascorbic acid biosynthetic process
M673_RS16060	COG0542	response to heat
M673_RS16070	COG2890	protein-(glutamine-N5) methyltransferase activity
M673_RS16075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M673_RS16085	COG0527	aspartate kinase activity
M673_RS16090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M673_RS16120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M673_RS16130	COG1040	competence protein
M673_RS16135	COG2226	methyltransferase
M673_RS16150	COG0494	nUDIX hydrolase
M673_RS16160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M673_RS16165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M673_RS16170	COG0653	protein targeting
M673_RS16185	COG0825	malonyl-CoA metabolic process
M673_RS16190	COG4974	Belongs to the 'phage' integrase family
M673_RS16200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M673_RS16205	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M673_RS16240	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M673_RS16245	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M673_RS16255	COG0384	phenazine biosynthesis protein PhzF
M673_RS16285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M673_RS16295	COG0667	Aldo Keto reductase
M673_RS16305	COG2264	protein methyltransferase activity
M673_RS16310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M673_RS16315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M673_RS16320	COG0287	Prephenate dehydrogenase
M673_RS16350	COG2884	Cell division ATP-binding protein ftsE
M673_RS16370	COG4106	trans-aconitate 2-methyltransferase activity
M673_RS16390	COG0165	Argininosuccinate lyase
M673_RS16395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M673_RS16400	COG1250	3-hydroxyacyl-CoA dehydrogenase
M673_RS16405	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M673_RS16410	COG2086	electron transfer activity
M673_RS16435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M673_RS16495	COG1396	sequence-specific DNA binding
M673_RS16515	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M673_RS16550	COG0438	transferase activity, transferring glycosyl groups
M673_RS16590	COG5002	protein histidine kinase activity
M673_RS16600	COG4565	transcriptional regulatory protein
M673_RS16605	COG1846	Transcriptional regulator
M673_RS16645	COG1879	ABC-type sugar transport system periplasmic component
M673_RS16650	COG1129	ABC transporter
M673_RS16655	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_RS16660	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_RS16665	COG0280	phosphate acetyltransferase
M673_RS16665	COG0281	malic enzyme
M673_RS16675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M673_RS16680	COG0840	transmembrane signaling receptor activity
M673_RS16695	COG1280	lysine exporter protein (LysE YggA)
M673_RS16705	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
M673_RS16710	COG1823	symporter activity
M673_RS16715	COG0561	phosphatase activity
M673_RS16720	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M673_RS16735	COG0848	biopolymer transport protein
M673_RS16810	COG0745	RESPONSE REGULATOR receiver
M673_RS16815	COG0784	Response regulator, receiver
M673_RS16815	COG2205	protein histidine kinase activity
M673_RS16820	COG3273	potassium ion transport
M673_RS16820	COG0471	metal ion transport
M673_RS16865	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M673_RS16870	COG1304	FMN binding
M673_RS16885	COG4122	O-methyltransferase activity
M673_RS16925	COG0840	transmembrane signaling receptor activity
M673_RS16930	COG1573	uracil-dna glycosylase
M673_RS16940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M673_RS16945	COG2115	Belongs to the xylose isomerase family
M673_RS16950	COG1609	Transcriptional regulator
M673_RS16955	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M673_RS16995	COG2197	response regulator
M673_RS17005	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M673_RS17015	COG1088	dTDP-glucose 4,6-dehydratase activity
M673_RS17030	COG0268	Binds directly to 16S ribosomal RNA
M673_RS17160	COG1074	ATP-dependent DNA helicase activity
M673_RS17210	COG0284	orotidine-5'-phosphate decarboxylase activity
M673_RS17215	COG3920	Histidine kinase
M673_RS17230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M673_RS17230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M673_RS17720	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M673_RS17800	COG0747	negative chemotaxis
M673_RS17835	COG4948	Mandelate Racemase Muconate Lactonizing
M673_RS18135	COG1137	ATPase activity
M673_RS18145	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M673_RS18550	COG1486	melibiose metabolic process
M673_RS18555	COG0747	negative chemotaxis
M673_RS19010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M673_RS19200	COG0802	atpase or kinase
M673_RS19425	COG0840	transmembrane signaling receptor activity
M673_RS19620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M673_RS19885	COG0444	Belongs to the ABC transporter superfamily
M673_RS20005	COG2202	Pas domain
M673_RS20005	COG3920	Histidine kinase
M673_RS20155	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M673_RS20285	COG2954	triphosphatase activity
M673_RS20355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M673_RS20525	COG0552	protein localization to endoplasmic reticulum
M673_RS20560	COG3118	belongs to the thioredoxin family
M673_RS20720	COG0747	negative chemotaxis
M673_RS20820	COG1609	Transcriptional regulator
M673_RS20825	COG4774	siderophore transport
M673_RS20915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M673_RS20945	COG2814	Major facilitator Superfamily
M673_RS20955	COG1960	acyl-CoA dehydrogenase activity
M673_RS21320	COG0443	Heat shock 70 kDa protein
M673_RS21455	COG1785	Belongs to the alkaline phosphatase family
M673_RS21520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M673_RS22420	COG1053	succinate dehydrogenase
M673_RS22445	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M673_RS22495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M673_RS22630	COG3920	Histidine kinase
M673_RS22675	COG2267	carboxylic ester hydrolase activity
M673_RS22900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M673_RS22940	COG3706	GGDEF domain
M673_RS23165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_RS23240	COG0285	dihydrofolate synthase activity
M673_RS23275	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M673_RS23365	COG5001	Diguanylate cyclase
M673_RS23365	COG4251	negative regulation of phosphorylation
M673_RS23365	COG3706	GGDEF domain
M673_RS23365	COG2203	Gaf domain