locus-tag	class	description
Sa4125_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Sa4125_RS00035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Sa4125_RS00040	COG0840	transmembrane signaling receptor activity
Sa4125_RS00045	COG0840	transmembrane signaling receptor activity
Sa4125_RS00050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Sa4125_RS00055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Sa4125_RS00065	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Sa4125_RS00070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Sa4125_RS00075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Sa4125_RS00080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Sa4125_RS00085	COG0792	nuclease activity
Sa4125_RS00090	COG1487	ribonuclease activity
Sa4125_RS00100	COG0189	ligase activity
Sa4125_RS00200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Sa4125_RS00210	COG2203	Gaf domain
Sa4125_RS00210	COG4251	negative regulation of phosphorylation
Sa4125_RS00210	COG3706	GGDEF domain
Sa4125_RS00210	COG5001	Diguanylate cyclase
Sa4125_RS00225	COG1595	DNA-templated transcription, initiation
Sa4125_RS00240	COG1376	ErfK ybiS ycfS ynhG family protein
Sa4125_RS00250	COG1309	transcriptional regulator
Sa4125_RS00255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Sa4125_RS00260	COG0785	Cytochrome C biogenesis protein
Sa4125_RS00275	COG2133	pyrroloquinoline quinone binding
Sa4125_RS00280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa4125_RS00290	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Sa4125_RS00310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Sa4125_RS00315	COG1132	(ABC) transporter
Sa4125_RS00320	COG0837	glucose binding
Sa4125_RS00325	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
Sa4125_RS00330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Sa4125_RS00330	COG0072	phenylalanine-tRNA ligase activity
Sa4125_RS00350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Sa4125_RS00360	COG0785	Cytochrome C biogenesis protein
Sa4125_RS00370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Sa4125_RS00375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Sa4125_RS00400	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Sa4125_RS00405	COG0424	maF-like protein
Sa4125_RS00410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Sa4125_RS00415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Sa4125_RS00430	COG1595	DNA-templated transcription, initiation
Sa4125_RS00435	COG1012	belongs to the aldehyde dehydrogenase family
Sa4125_RS00455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sa4125_RS00475	COG1132	(ABC) transporter
Sa4125_RS00485	COG1234	tRNA 3'-trailer cleavage
Sa4125_RS00500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa4125_RS00505	COG0601	transmembrane transport
Sa4125_RS00510	COG0747	negative chemotaxis
Sa4125_RS00545	COG0438	transferase activity, transferring glycosyl groups
Sa4125_RS00550	COG0438	transferase activity, transferring glycosyl groups
Sa4125_RS00560	COG0840	transmembrane signaling receptor activity
Sa4125_RS00565	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS00575	COG1252	NADH dehydrogenase
Sa4125_RS00580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Sa4125_RS00585	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Sa4125_RS00590	COG2080	2 iron, 2 sulfur cluster binding
Sa4125_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS00630	COG1492	cobalamin metabolic process
Sa4125_RS00675	COG2875	Belongs to the precorrin methyltransferase family
Sa4125_RS00685	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Sa4125_RS00690	COG1797	cobyrinic acid a,c-diamide synthase activity
Sa4125_RS00700	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Sa4125_RS00705	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Sa4125_RS00715	COG5001	Diguanylate cyclase
Sa4125_RS00735	COG2943	transferase activity, transferring hexosyl groups
Sa4125_RS00745	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Sa4125_RS00760	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Sa4125_RS00765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Sa4125_RS00770	COG0512	Glutamine amidotransferase of anthranilate synthase
Sa4125_RS00775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Sa4125_RS00795	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Sa4125_RS00800	COG4154	Belongs to the RbsD FucU family
Sa4125_RS00805	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Sa4125_RS00820	COG1063	alcohol dehydrogenase
Sa4125_RS00825	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS00830	COG3265	gluconokinase activity
Sa4125_RS00865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sa4125_RS00870	COG1744	ABC transporter substrate-binding protein PnrA-like
Sa4125_RS00875	COG2900	Belongs to the SlyX family
Sa4125_RS00880	COG3845	ABC transporter
Sa4125_RS00890	COG4603	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS00895	COG1079	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS00910	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Sa4125_RS00915	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Sa4125_RS00925	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Sa4125_RS00930	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Sa4125_RS00970	COG4964	Belongs to the GSP D family
Sa4125_RS01005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Sa4125_RS01015	COG0791	NLP P60 protein
Sa4125_RS01020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Sa4125_RS01025	COG1051	belongs to the nudix hydrolase family
Sa4125_RS01030	COG4172	Belongs to the ABC transporter superfamily
Sa4125_RS01035	COG1230	cation diffusion facilitator family transporter
Sa4125_RS01050	COG4239	(ABC) transporter, permease
Sa4125_RS01055	COG4174	ABC transporter (Permease)
Sa4125_RS01060	COG4166	transmembrane transport
Sa4125_RS01065	COG4166	transmembrane transport
Sa4125_RS01080	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Sa4125_RS01085	COG1605	Chorismate mutase
Sa4125_RS01085	COG0077	Prephenate dehydratase
Sa4125_RS01090	COG2816	NAD+ diphosphatase activity
Sa4125_RS01105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Sa4125_RS01115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Sa4125_RS01125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Sa4125_RS01135	COG0242	peptide deformylase activity
Sa4125_RS01140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Sa4125_RS01145	COG0101	tRNA pseudouridine synthase activity
Sa4125_RS01150	COG2814	Major facilitator Superfamily
Sa4125_RS01165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Sa4125_RS01175	COG2171	N-acyltransferase activity
Sa4125_RS01195	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Sa4125_RS01205	COG3214	Protein conserved in bacteria
Sa4125_RS01225	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Sa4125_RS01230	COG0745	RESPONSE REGULATOR receiver
Sa4125_RS01235	COG2201	protein-glutamate methylesterase activity
Sa4125_RS01240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Sa4125_RS01245	COG0835	chemotaxis
Sa4125_RS01250	COG0643	Histidine kinase
Sa4125_RS01250	COG2198	Histidine kinase
Sa4125_RS01255	COG0745	RESPONSE REGULATOR receiver
Sa4125_RS01265	COG0840	transmembrane signaling receptor activity
Sa4125_RS01270	COG0514	ATP-dependent DNA helicase (RecQ)
Sa4125_RS01275	COG4774	siderophore transport
Sa4125_RS01280	COG1132	(ABC) transporter
Sa4125_RS01305	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Sa4125_RS01325	COG0596	Alpha beta hydrolase
Sa4125_RS01335	COG1126	abc transporter atp-binding protein
Sa4125_RS01360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Sa4125_RS01370	COG3335	DDE superfamily endonuclease
Sa4125_RS01375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Sa4125_RS01380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Sa4125_RS01385	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Sa4125_RS01390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Sa4125_RS01395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Sa4125_RS01405	COG0583	DNA-binding transcription factor activity
Sa4125_RS01410	COG0697	spore germination
Sa4125_RS01435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_RS01440	COG1126	abc transporter atp-binding protein
Sa4125_RS01460	COG3852	Histidine kinase
Sa4125_RS01465	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Sa4125_RS01470	COG0594	ribonuclease P activity
Sa4125_RS01485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Sa4125_RS01505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Sa4125_RS01510	COG5328	Belongs to the UPF0262 family
Sa4125_RS01515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Sa4125_RS01560	COG3206	protein involved in exopolysaccharide biosynthesis
Sa4125_RS01560	COG0489	protein tyrosine kinase activity
Sa4125_RS01565	COG2205	protein histidine kinase activity
Sa4125_RS01585	COG1570	exodeoxyribonuclease VII activity
Sa4125_RS01590	COG0583	DNA-binding transcription factor activity
Sa4125_RS01600	COG1253	flavin adenine dinucleotide binding
Sa4125_RS01620	COG2818	Glycosylase
Sa4125_RS01635	COG1388	LysM domain
Sa4125_RS01635	COG1376	ErfK ybiS ycfS ynhG family protein
Sa4125_RS01640	COG1376	ErfK ybiS ycfS ynhG family protein
Sa4125_RS01640	COG1388	LysM domain
Sa4125_RS01645	COG0174	glutamine synthetase
Sa4125_RS01655	COG2066	Belongs to the glutaminase family
Sa4125_RS01660	COG0247	lactate metabolic process
Sa4125_RS01675	COG0277	FAD linked oxidase domain protein
Sa4125_RS01685	COG0277	FAD linked oxidase domain protein
Sa4125_RS01690	COG0247	lactate metabolic process
Sa4125_RS01695	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Sa4125_RS01705	COG1139	Iron-sulfur cluster binding protein
Sa4125_RS01710	COG1556	Lactate utilization protein
Sa4125_RS01715	COG1280	lysine exporter protein (LysE YggA)
Sa4125_RS01725	COG0124	histidyl-tRNA synthetase
Sa4125_RS01730	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Sa4125_RS01735	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Sa4125_RS01740	COG5001	Diguanylate cyclase
Sa4125_RS01740	COG4251	negative regulation of phosphorylation
Sa4125_RS01740	COG3706	GGDEF domain
Sa4125_RS01740	COG2203	Gaf domain
Sa4125_RS01775	COG0730	response to heat
Sa4125_RS01785	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Sa4125_RS01800	COG0196	riboflavin kinase activity
Sa4125_RS01805	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Sa4125_RS01815	COG0590	tRNA wobble adenosine to inosine editing
Sa4125_RS01825	COG0742	ribosomal rna small subunit methyltransferase
Sa4125_RS01830	COG0612	Peptidase, M16
Sa4125_RS01835	COG0612	Peptidase, M16
Sa4125_RS01840	COG1752	Esterase of the alpha-beta hydrolase superfamily
Sa4125_RS01850	COG0475	glutathione-regulated potassium exporter activity
Sa4125_RS01850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Sa4125_RS01855	COG0312	modulator of DNA gyrase
Sa4125_RS01875	COG1519	Transferase
Sa4125_RS01900	COG0033	Phosphoglucomutase
Sa4125_RS01905	COG0297	glycogen (starch) synthase activity
Sa4125_RS01910	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Sa4125_RS01915	COG0058	SHG alpha-glucan phosphorylase activity
Sa4125_RS01920	COG0166	Belongs to the GPI family
Sa4125_RS01930	COG1012	belongs to the aldehyde dehydrogenase family
Sa4125_RS01940	COG0729	surface antigen
Sa4125_RS01985	COG1294	oxidase, subunit
Sa4125_RS01990	COG1271	oxidase subunit
Sa4125_RS02035	COG1304	FMN binding
Sa4125_RS02040	COG0583	DNA-binding transcription factor activity
Sa4125_RS02045	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Sa4125_RS02060	COG0126	phosphoglycerate kinase activity
Sa4125_RS02075	COG4451	ribulose bisphosphate carboxylase, small
Sa4125_RS02090	COG0778	Nitroreductase
Sa4125_RS02100	COG1960	acyl-CoA dehydrogenase activity
Sa4125_RS02115	COG0446	pyridine nucleotide-disulphide oxidoreductase
Sa4125_RS02115	COG1902	pentaerythritol trinitrate reductase activity
Sa4125_RS02125	COG4303	Ethanolamine ammonia lyase large subunit
Sa4125_RS02130	COG4302	ethanolamine ammonia-lyase activity
Sa4125_RS02135	COG0531	amino acid
Sa4125_RS02145	COG0861	Integral membrane protein TerC family
Sa4125_RS02165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Sa4125_RS02170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Sa4125_RS02175	COG1121	(ABC) transporter
Sa4125_RS02180	COG0803	Belongs to the bacterial solute-binding protein 9 family
Sa4125_RS02190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa4125_RS02195	COG1802	Transcriptional regulator
Sa4125_RS02200	COG1904	glucuronate isomerase
Sa4125_RS02205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Sa4125_RS02220	COG0246	Mannitol dehydrogenase
Sa4125_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS02245	COG1054	Belongs to the UPF0176 family
Sa4125_RS02260	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Sa4125_RS02295	COG2226	methyltransferase
Sa4125_RS02315	COG2963	transposase activity
Sa4125_RS02320	COG3436	PFAM IS66 Orf2 family protein
Sa4125_RS02325	COG2433	Pfam Transposase IS66
Sa4125_RS02355	COG3328	transposase activity
Sa4125_RS02390	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Sa4125_RS02410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sa4125_RS02430	COG0438	transferase activity, transferring glycosyl groups
Sa4125_RS02440	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Sa4125_RS02460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sa4125_RS02465	COG0463	Glycosyl transferase, family 2
Sa4125_RS02495	COG0438	transferase activity, transferring glycosyl groups
Sa4125_RS02525	COG3206	protein involved in exopolysaccharide biosynthesis
Sa4125_RS02525	COG0489	protein tyrosine kinase activity
Sa4125_RS02550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Sa4125_RS02560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Sa4125_RS02565	COG2197	response regulator
Sa4125_RS02590	COG3328	transposase activity
Sa4125_RS02620	COG0583	DNA-binding transcription factor activity
Sa4125_RS02625	COG2814	Major facilitator Superfamily
Sa4125_RS02635	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS02665	COG3246	L-lysine catabolic process to acetate
Sa4125_RS02670	COG1250	3-hydroxyacyl-CoA dehydrogenase
Sa4125_RS02690	COG1802	Transcriptional regulator
Sa4125_RS02695	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS02735	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Sa4125_RS02740	COG1802	Transcriptional regulator
Sa4125_RS02750	COG0640	Transcriptional regulator
Sa4125_RS02760	COG5001	Diguanylate cyclase
Sa4125_RS02760	COG3300	MHYT domain
Sa4125_RS02765	COG3290	protein histidine kinase activity
Sa4125_RS02800	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Sa4125_RS02805	COG2010	Cytochrome c
Sa4125_RS02805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Sa4125_RS02830	COG0477	Major facilitator Superfamily
Sa4125_RS02835	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Sa4125_RS02855	COG0753	catalase activity
Sa4125_RS02870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Sa4125_RS02870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Sa4125_RS02875	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Sa4125_RS02885	COG0519	Catalyzes the synthesis of GMP from XMP
Sa4125_RS02885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Sa4125_RS02895	COG3788	relative of glutathione S-transferase, MAPEG superfamily
Sa4125_RS02910	COG1160	GTP binding
Sa4125_RS02925	COG0356	it plays a direct role in the translocation of protons across the membrane
Sa4125_RS02930	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Sa4125_RS02935	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Sa4125_RS02940	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Sa4125_RS02945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Sa4125_RS02960	COG0521	Mo-molybdopterin cofactor biosynthetic process
Sa4125_RS02965	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Sa4125_RS02975	COG0142	geranyltranstransferase activity
Sa4125_RS03000	COG0752	glycyl-tRNA synthetase alpha subunit
Sa4125_RS03005	COG2321	neutral zinc metallopeptidase
Sa4125_RS03015	COG0751	glycine-tRNA ligase activity
Sa4125_RS03025	COG0009	L-threonylcarbamoyladenylate synthase
Sa4125_RS03045	COG0151	Belongs to the GarS family
Sa4125_RS03050	COG1960	acyl-CoA dehydrogenase activity
Sa4125_RS03055	COG0179	Fumarylacetoacetate (FAA) hydrolase
Sa4125_RS03060	COG1960	acyl-CoA dehydrogenase activity
Sa4125_RS03065	COG1024	Enoyl-CoA hydratase
Sa4125_RS03085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Sa4125_RS03090	COG1722	exodeoxyribonuclease VII activity
Sa4125_RS03095	COG0123	including yeast histone deacetylase and acetoin utilization protein
Sa4125_RS03110	COG0406	alpha-ribazole phosphatase activity
Sa4125_RS03115	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Sa4125_RS03120	COG0484	heat shock protein binding
Sa4125_RS03130	COG0259	pyridoxamine-phosphate oxidase activity
Sa4125_RS03140	COG0312	modulator of DNA gyrase
Sa4125_RS03150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Sa4125_RS03155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Sa4125_RS03160	COG0109	protoheme IX farnesyltransferase activity
Sa4125_RS03180	COG3346	SURF1 family
Sa4125_RS03185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Sa4125_RS03190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Sa4125_RS03195	COG0328	RNA-DNA hybrid ribonuclease activity
Sa4125_RS03200	COG0678	peroxiredoxin activity
Sa4125_RS03200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Sa4125_RS03210	COG1678	Uncharacterized ACR, COG1678
Sa4125_RS03215	COG5001	Diguanylate cyclase
Sa4125_RS03225	COG0612	Peptidase, M16
Sa4125_RS03240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Sa4125_RS03245	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Sa4125_RS03250	COG1011	Hydrolase
Sa4125_RS03255	COG1194	a g-specific adenine glycosylase
Sa4125_RS03270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Sa4125_RS03275	COG0574	Belongs to the PEP-utilizing enzyme family
Sa4125_RS03275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Sa4125_RS03285	COG0318	PFAM AMP-dependent synthetase and ligase
Sa4125_RS03300	COG1187	pseudouridine synthase activity
Sa4125_RS03315	COG0840	transmembrane signaling receptor activity
Sa4125_RS03330	COG3254	rhamnose metabolic process
Sa4125_RS03335	COG1063	alcohol dehydrogenase
Sa4125_RS03340	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS03355	COG1802	Transcriptional regulator
Sa4125_RS03360	COG0840	transmembrane signaling receptor activity
Sa4125_RS03380	COG3833	ABC-type maltose transport systems, permease component
Sa4125_RS03385	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sa4125_RS03395	COG3842	ATPase activity
Sa4125_RS03400	COG2188	Transcriptional regulator
Sa4125_RS03420	COG0765	amino acid transport
Sa4125_RS03425	COG1126	abc transporter atp-binding protein
Sa4125_RS03430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Sa4125_RS03440	COG0444	Belongs to the ABC transporter superfamily
Sa4125_RS03445	COG4608	Belongs to the ABC transporter superfamily
Sa4125_RS03455	COG0601	transmembrane transport
Sa4125_RS03460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa4125_RS03470	COG3328	transposase activity
Sa4125_RS03475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sa4125_RS03480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Sa4125_RS03480	COG1017	nitric oxide dioxygenase activity
Sa4125_RS03485	COG2346	COG2346, Truncated hemoglobins
Sa4125_RS03490	COG1959	2 iron, 2 sulfur cluster binding
Sa4125_RS03500	COG3328	transposase activity
Sa4125_RS03540	COG1609	Transcriptional regulator
Sa4125_RS03545	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS03555	COG1129	ABC transporter
Sa4125_RS03560	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS03565	COG2376	Dihydroxyacetone kinase
Sa4125_RS03575	COG0667	Aldo Keto reductase
Sa4125_RS03610	COG3328	transposase activity
Sa4125_RS03620	COG1295	ribonuclease BN
Sa4125_RS03630	COG1250	3-hydroxyacyl-CoA dehydrogenase
Sa4125_RS03630	COG1024	Enoyl-CoA hydratase
Sa4125_RS03635	COG2200	EAL domain
Sa4125_RS03635	COG2202	Pas domain
Sa4125_RS03635	COG2199	diguanylate cyclase activity
Sa4125_RS03645	COG0183	Belongs to the thiolase family
Sa4125_RS03655	COG1960	acyl-CoA dehydrogenase activity
Sa4125_RS03690	COG1201	RNA secondary structure unwinding
Sa4125_RS03705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Sa4125_RS03710	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS03720	COG3263	regulation of cellular component size
Sa4125_RS03740	COG0842	Transport permease protein
Sa4125_RS03745	COG1131	(ABC) transporter
Sa4125_RS03755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Sa4125_RS03765	COG0625	glutathione transferase activity
Sa4125_RS03770	COG1692	metallophosphoesterase
Sa4125_RS03785	COG0217	transcriptional regulatory protein
Sa4125_RS03795	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Sa4125_RS03810	COG0632	four-way junction helicase activity
Sa4125_RS03825	COG2255	four-way junction helicase activity
Sa4125_RS03835	COG0824	Thioesterase
Sa4125_RS03845	COG0848	biopolymer transport protein
Sa4125_RS03855	COG0823	Involved in the tonB-independent uptake of proteins
Sa4125_RS03860	COG2885	chlorophyll binding
Sa4125_RS03880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Sa4125_RS03885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Sa4125_RS03890	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Sa4125_RS03900	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Sa4125_RS03910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Sa4125_RS03920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Sa4125_RS03935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Sa4125_RS03940	COG0564	pseudouridine synthase activity
Sa4125_RS03955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Sa4125_RS03970	COG1278	Cold shock
Sa4125_RS03980	COG0357	Ribosomal RNA small subunit methyltransferase G
Sa4125_RS03980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Sa4125_RS04005	COG0745	RESPONSE REGULATOR receiver
Sa4125_RS04025	COG0482	sulfurtransferase activity
Sa4125_RS04040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Sa4125_RS04045	COG1278	Cold shock
Sa4125_RS04055	COG4191	Histidine kinase
Sa4125_RS04055	COG0784	Response regulator, receiver
Sa4125_RS04060	COG2202	Pas domain
Sa4125_RS04060	COG3920	Histidine kinase
Sa4125_RS04105	COG1063	alcohol dehydrogenase
Sa4125_RS04110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Sa4125_RS04110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Sa4125_RS04115	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Sa4125_RS04120	COG0861	Integral membrane protein TerC family
Sa4125_RS04125	COG0583	DNA-binding transcription factor activity
Sa4125_RS04150	COG3383	formate dehydrogenase (NAD+) activity
Sa4125_RS04155	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Sa4125_RS04205	COG0546	phosphoglycolate phosphatase activity
Sa4125_RS04225	COG1396	sequence-specific DNA binding
Sa4125_RS04235	COG0069	glutamate synthase activity
Sa4125_RS04240	COG2218	PFAM glutamate synthase alpha subunit domain protein
Sa4125_RS04245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Sa4125_RS04255	COG4977	sequence-specific DNA binding
Sa4125_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS04270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Sa4125_RS04270	COG0446	pyridine nucleotide-disulphide oxidoreductase
Sa4125_RS04275	COG4311	Sarcosine oxidase, delta subunit
Sa4125_RS04280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sa4125_RS04285	COG4977	sequence-specific DNA binding
Sa4125_RS04295	COG0010	Belongs to the arginase family
Sa4125_RS04305	COG2391	methyltransferase activity
Sa4125_RS04320	COG1090	epimerase
Sa4125_RS04325	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS04330	COG1129	ABC transporter
Sa4125_RS04345	COG0730	response to heat
Sa4125_RS04355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_RS04365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_RS04375	COG2186	Transcriptional regulator
Sa4125_RS04390	COG0473	3-isopropylmalate dehydrogenase activity
Sa4125_RS04400	COG0596	Alpha beta hydrolase
Sa4125_RS04415	COG0473	3-isopropylmalate dehydrogenase activity
Sa4125_RS04430	COG2186	Transcriptional regulator
Sa4125_RS04435	COG1178	ABC-type Fe3 transport system permease component
Sa4125_RS04445	COG3842	ATPase activity
Sa4125_RS04455	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS04480	COG1802	Transcriptional regulator
Sa4125_RS04485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Sa4125_RS04515	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Sa4125_RS04520	COG3328	transposase activity
Sa4125_RS04525	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
Sa4125_RS04530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Sa4125_RS04555	COG3328	transposase activity
Sa4125_RS04575	COG3206	protein involved in exopolysaccharide biosynthesis
Sa4125_RS04575	COG0489	protein tyrosine kinase activity
Sa4125_RS04585	COG2963	transposase activity
Sa4125_RS04590	COG3436	PFAM IS66 Orf2 family protein
Sa4125_RS04595	COG2433	Pfam Transposase IS66
Sa4125_RS04600	COG2327	Polysaccharide pyruvyl transferase
Sa4125_RS04605	COG1215	transferase activity, transferring glycosyl groups
Sa4125_RS04620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Sa4125_RS04625	COG1376	ErfK ybiS ycfS ynhG family protein
Sa4125_RS04640	COG0438	transferase activity, transferring glycosyl groups
Sa4125_RS04645	COG1215	transferase activity, transferring glycosyl groups
Sa4125_RS04650	COG1215	transferase activity, transferring glycosyl groups
Sa4125_RS04655	COG3307	-O-antigen
Sa4125_RS04665	COG3328	transposase activity
Sa4125_RS04680	COG4251	negative regulation of phosphorylation
Sa4125_RS04685	COG3328	transposase activity
Sa4125_RS04690	COG4251	negative regulation of phosphorylation
Sa4125_RS04695	COG3328	transposase activity
Sa4125_RS04700	COG5001	Diguanylate cyclase
Sa4125_RS04700	COG4251	negative regulation of phosphorylation
Sa4125_RS04700	COG3706	GGDEF domain
Sa4125_RS04700	COG2203	Gaf domain
Sa4125_RS04735	COG1793	dna ligase
Sa4125_RS04750	COG0123	including yeast histone deacetylase and acetoin utilization protein
Sa4125_RS04755	COG0534	Mate efflux family protein
Sa4125_RS04760	COG0167	dihydroorotate dehydrogenase activity
Sa4125_RS04775	COG0657	acetylesterase activity
Sa4125_RS04780	COG0432	Pfam Uncharacterised protein family UPF0047
Sa4125_RS04800	COG2198	Histidine kinase
Sa4125_RS04800	COG0784	Response regulator, receiver
Sa4125_RS04800	COG2205	protein histidine kinase activity
Sa4125_RS04805	COG1970	mechanosensitive ion channel activity
Sa4125_RS04810	COG0436	Aminotransferase
Sa4125_RS04820	COG0156	8-amino-7-oxononanoate synthase activity
Sa4125_RS04840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Sa4125_RS04850	COG2204	response regulator
Sa4125_RS04865	COG1840	ABC-type Fe3 transport system, periplasmic component
Sa4125_RS04880	COG3842	ATPase activity
Sa4125_RS04910	COG3328	transposase activity
Sa4125_RS04955	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Sa4125_RS04960	COG4589	Belongs to the CDS family
Sa4125_RS04975	COG2124	cytochrome p450
Sa4125_RS04980	COG1309	transcriptional regulator
Sa4125_RS04990	COG0436	Aminotransferase
Sa4125_RS05000	COG3300	MHYT domain
Sa4125_RS05000	COG5001	Diguanylate cyclase
Sa4125_RS05010	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Sa4125_RS05015	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Sa4125_RS05050	COG3718	enzyme involved in inositol metabolism
Sa4125_RS05060	COG3962	Belongs to the TPP enzyme family
Sa4125_RS05065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa4125_RS05070	COG0673	inositol 2-dehydrogenase activity
Sa4125_RS05085	COG0673	inositol 2-dehydrogenase activity
Sa4125_RS05095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Sa4125_RS05105	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Sa4125_RS05175	COG0071	Belongs to the small heat shock protein (HSP20) family
Sa4125_RS05200	COG0070	glutamate synthase
Sa4125_RS05200	COG0069	glutamate synthase activity
Sa4125_RS05200	COG0067	glutamate synthase
Sa4125_RS05220	COG2951	lytic endotransglycosylase activity
Sa4125_RS05225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Sa4125_RS05240	COG0330	HflC and HflK could
Sa4125_RS05255	COG3750	Belongs to the UPF0335 family
Sa4125_RS05260	COG4957	zinc ion binding
Sa4125_RS05275	COG5310	Homospermidine synthase
Sa4125_RS05290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Sa4125_RS05300	COG0469	pyruvate kinase activity
Sa4125_RS05305	COG0457	Tetratricopeptide repeat
Sa4125_RS05310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Sa4125_RS05315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Sa4125_RS05320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Sa4125_RS05340	COG0352	thiamine-phosphate diphosphorylase activity
Sa4125_RS05355	COG0483	inositol monophosphate 1-phosphatase activity
Sa4125_RS05370	COG1132	(ABC) transporter
Sa4125_RS05375	COG0254	rRNA binding
Sa4125_RS05385	COG0129	dihydroxy-acid dehydratase activity
Sa4125_RS05390	COG0363	glucosamine-6-phosphate deaminase activity
Sa4125_RS05395	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Sa4125_RS05400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sa4125_RS05425	COG2224	Isocitrate lyase
Sa4125_RS05455	COG3842	ATPase activity
Sa4125_RS05460	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sa4125_RS05465	COG1177	transmembrane transport
Sa4125_RS05480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Sa4125_RS05490	COG3321	synthase
Sa4125_RS05490	COG4221	oxidoreductase activity
Sa4125_RS05490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Sa4125_RS05490	COG0604	alcohol dehydrogenase
Sa4125_RS05510	COG5002	protein histidine kinase activity
Sa4125_RS05515	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Sa4125_RS05520	COG0573	inorganic phosphate transmembrane transporter activity
Sa4125_RS05525	COG0581	inorganic phosphate transmembrane transporter activity
Sa4125_RS05530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Sa4125_RS05535	COG0704	Plays a role in the regulation of phosphate uptake
Sa4125_RS05540	COG0745	RESPONSE REGULATOR receiver
Sa4125_RS05555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Sa4125_RS05560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Sa4125_RS05570	COG2967	ApaG domain
Sa4125_RS05575	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Sa4125_RS05585	COG0717	Belongs to the dCTP deaminase family
Sa4125_RS05615	COG3328	transposase activity
Sa4125_RS05715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sa4125_RS05720	COG1335	isochorismatase
Sa4125_RS05735	COG0559	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS05760	COG0174	glutamine synthetase
Sa4125_RS05765	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS05790	COG1509	lysine 2,3-aminomutase activity
Sa4125_RS05795	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Sa4125_RS05800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Sa4125_RS05825	COG3328	transposase activity
Sa4125_RS05830	COG3842	ATPase activity
Sa4125_RS05840	COG1840	ABC-type Fe3 transport system, periplasmic component
Sa4125_RS05860	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Sa4125_RS05870	COG0840	transmembrane signaling receptor activity
Sa4125_RS05885	COG2433	Pfam Transposase IS66
Sa4125_RS05890	COG3436	PFAM IS66 Orf2 family protein
Sa4125_RS05895	COG2963	transposase activity
Sa4125_RS05905	COG3328	transposase activity
Sa4125_RS05930	COG3328	transposase activity
Sa4125_RS05940	COG0840	transmembrane signaling receptor activity
Sa4125_RS05955	COG0583	DNA-binding transcription factor activity
Sa4125_RS05965	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Sa4125_RS05980	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sa4125_RS05985	COG1177	transmembrane transport
Sa4125_RS06000	COG1686	Belongs to the peptidase S11 family
Sa4125_RS06015	COG1309	transcriptional regulator
Sa4125_RS06030	COG0028	Belongs to the TPP enzyme family
Sa4125_RS06035	COG5001	Diguanylate cyclase
Sa4125_RS06035	COG3300	MHYT domain
Sa4125_RS06040	COG2373	Large extracellular alpha-helical protein
Sa4125_RS06045	COG4953	penicillin-binding protein 1C
Sa4125_RS06065	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Sa4125_RS06075	COG2166	iron-sulfur cluster assembly
Sa4125_RS06085	COG2205	protein histidine kinase activity
Sa4125_RS06120	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Sa4125_RS06125	COG2983	Belongs to the UPF0260 family
Sa4125_RS06140	COG4695	Portal protein
Sa4125_RS06260	COG4235	cytochrome complex assembly
Sa4125_RS06265	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Sa4125_RS06270	COG1138	Cytochrome C-type biogenesis protein
Sa4125_RS06275	COG3088	subunit of a heme lyase
Sa4125_RS06280	COG5001	Diguanylate cyclase
Sa4125_RS06280	COG3706	GGDEF domain
Sa4125_RS06280	COG4251	negative regulation of phosphorylation
Sa4125_RS06280	COG2203	Gaf domain
Sa4125_RS06290	COG0745	RESPONSE REGULATOR receiver
Sa4125_RS06300	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS06305	COG0642	Histidine kinase
Sa4125_RS06325	COG2897	thiosulfate sulfurtransferase activity
Sa4125_RS06330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Sa4125_RS06340	COG0415	Belongs to the DNA photolyase family
Sa4125_RS06345	COG2205	protein histidine kinase activity
Sa4125_RS06345	COG2202	Pas domain
Sa4125_RS06350	COG0308	aminopeptidase N
Sa4125_RS06390	COG3328	transposase activity
Sa4125_RS06430	COG1573	uracil-dna glycosylase
Sa4125_RS06435	COG0596	Alpha beta hydrolase
Sa4125_RS06455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Sa4125_RS06480	COG0625	glutathione transferase activity
Sa4125_RS06510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Sa4125_RS06515	COG0642	Histidine kinase
Sa4125_RS06530	COG0745	RESPONSE REGULATOR receiver
Sa4125_RS06540	COG3328	transposase activity
Sa4125_RS06545	COG0671	phosphoesterase, PA-phosphatase related
Sa4125_RS06555	COG0697	spore germination
Sa4125_RS06560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Sa4125_RS06580	COG3743	rRNA binding
Sa4125_RS06580	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Sa4125_RS06585	COG0488	(ABC) transporter
Sa4125_RS06600	COG0251	oxidation-reduction process
Sa4125_RS06620	COG0105	UTP biosynthetic process
Sa4125_RS06630	COG0314	molybdopterin synthase activity
Sa4125_RS06650	COG0784	Response regulator, receiver
Sa4125_RS06655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Sa4125_RS06660	COG0322	excinuclease ABC activity
Sa4125_RS06670	COG0625	glutathione transferase activity
Sa4125_RS06680	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Sa4125_RS06685	COG1902	pentaerythritol trinitrate reductase activity
Sa4125_RS06695	COG0243	molybdopterin cofactor binding
Sa4125_RS06700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Sa4125_RS06705	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Sa4125_RS06710	COG0628	permease
Sa4125_RS06715	COG1484	DNA-dependent DNA replication
Sa4125_RS06720	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Sa4125_RS06735	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Sa4125_RS06740	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Sa4125_RS06745	COG5001	Diguanylate cyclase
Sa4125_RS06745	COG3300	MHYT domain
Sa4125_RS06750	COG1129	ABC transporter
Sa4125_RS06755	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS06760	COG1879	ABC-type sugar transport system periplasmic component
Sa4125_RS06770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Sa4125_RS06790	COG0739	heme binding
Sa4125_RS06790	COG0741	lytic transglycosylase activity
Sa4125_RS06790	COG1196	nuclear chromosome segregation
Sa4125_RS06795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Sa4125_RS06800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Sa4125_RS06805	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Sa4125_RS06810	COG0840	transmembrane signaling receptor activity
Sa4125_RS06815	COG1573	uracil-dna glycosylase
Sa4125_RS06825	COG1758	RNA polymerase activity
Sa4125_RS06835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Sa4125_RS06845	COG0736	holo-[acyl-carrier-protein] synthase activity
Sa4125_RS06850	COG0681	Belongs to the peptidase S26 family
Sa4125_RS06860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Sa4125_RS06875	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS06885	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Sa4125_RS06890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Sa4125_RS06900	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Sa4125_RS06910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Sa4125_RS06920	COG0640	Transcriptional regulator
Sa4125_RS06930	COG0215	cysteine-tRNA ligase activity
Sa4125_RS06950	COG2267	carboxylic ester hydrolase activity
Sa4125_RS06955	COG1363	Peptidase, m42
Sa4125_RS07010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sa4125_RS07015	COG1733	regulation of RNA biosynthetic process
Sa4125_RS07035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Sa4125_RS07040	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Sa4125_RS07045	COG1122	ATPase activity
Sa4125_RS07050	COG1268	BioY protein
Sa4125_RS07105	COG3328	transposase activity
Sa4125_RS07120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Sa4125_RS07140	COG0395	ABC-type sugar transport system, permease component
Sa4125_RS07150	COG3842	ATPase activity
Sa4125_RS07155	COG3842	ATPase activity
Sa4125_RS07185	COG1129	ABC transporter
Sa4125_RS07190	COG4214	carbohydrate transport
Sa4125_RS07195	COG4213	ABC transporter substrate-binding protein
Sa4125_RS07200	COG1940	carbohydrate kinase activity
Sa4125_RS07205	COG2115	Belongs to the xylose isomerase family
Sa4125_RS07210	COG1070	Carbohydrate kinase
Sa4125_RS07215	COG2205	protein histidine kinase activity
Sa4125_RS07225	COG0745	RESPONSE REGULATOR receiver
Sa4125_RS07230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Sa4125_RS07275	COG0175	sulfate reduction
Sa4125_RS07280	COG1216	Glycosyl transferase, family 2
Sa4125_RS07285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Sa4125_RS07300	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Sa4125_RS07355	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Sa4125_RS07360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Sa4125_RS07365	COG3959	Transketolase, thiamine diphosphate binding domain
Sa4125_RS07375	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Sa4125_RS07380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sa4125_RS07385	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Sa4125_RS07440	COG2826	transposase and inactivated derivatives, IS30 family
Sa4125_RS07525	COG2226	methyltransferase
Sa4125_RS07540	COG3328	transposase activity
Sa4125_RS07570	COG3328	transposase activity
Sa4125_RS07610	COG2202	Pas domain
Sa4125_RS07610	COG3920	Histidine kinase
Sa4125_RS07725	COG2826	transposase and inactivated derivatives, IS30 family
Sa4125_RS07755	COG3328	transposase activity
Sa4125_RS07765	COG0673	inositol 2-dehydrogenase activity
Sa4125_RS07775	COG5265	(ABC) transporter
Sa4125_RS07780	COG0688	phosphatidylethanolamine metabolic process
Sa4125_RS07785	COG1183	phosphatidylcholine synthase activity
Sa4125_RS07795	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Sa4125_RS07800	COG0546	phosphoglycolate phosphatase activity
Sa4125_RS07805	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Sa4125_RS07805	COG0517	IMP dehydrogenase activity
Sa4125_RS07810	COG4221	oxidoreductase activity
Sa4125_RS07815	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Sa4125_RS07840	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Sa4125_RS07850	COG0359	binds to the 23S rRNA
Sa4125_RS07860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Sa4125_RS07865	COG0360	Binds together with S18 to 16S ribosomal RNA
Sa4125_RS07870	COG3300	MHYT domain
Sa4125_RS07870	COG5001	Diguanylate cyclase
Sa4125_RS07875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Sa4125_RS07890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Sa4125_RS07895	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Sa4125_RS07900	COG1561	YicC-like family, N-terminal region
Sa4125_RS07905	COG0194	GDP metabolic process
Sa4125_RS07915	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Sa4125_RS07920	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Sa4125_RS07930	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Sa4125_RS07945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Sa4125_RS07955	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Sa4125_RS07965	COG0113	porphobilinogen synthase activity
Sa4125_RS07985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Sa4125_RS07990	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Sa4125_RS08005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sa4125_RS08010	COG0765	amino acid transport
Sa4125_RS08015	COG1126	abc transporter atp-binding protein
Sa4125_RS08025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Sa4125_RS08030	COG2814	Major facilitator Superfamily
Sa4125_RS08035	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Sa4125_RS08055	COG0416	fatty acid biosynthetic process
Sa4125_RS08060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Sa4125_RS08065	COG0776	regulation of translation
Sa4125_RS08105	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
Sa4125_RS08125	COG1596	polysaccharide export
Sa4125_RS08150	COG1612	heme a metabolic process
Sa4125_RS08155	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Sa4125_RS08160	COG0010	Belongs to the arginase family
Sa4125_RS08165	COG3328	transposase activity
Sa4125_RS08175	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Sa4125_RS08180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Sa4125_RS08190	COG1832	CoA-binding protein
Sa4125_RS08205	COG2124	cytochrome p450
Sa4125_RS08220	COG3300	MHYT domain
Sa4125_RS08220	COG5001	Diguanylate cyclase
Sa4125_RS08230	COG3386	PFAM SMP-30 Gluconolaconase
Sa4125_RS08235	COG0800	Aldolase
Sa4125_RS08240	COG3734	2-keto-3-deoxy-galactonokinase
Sa4125_RS08245	COG0129	dihydroxy-acid dehydratase activity
Sa4125_RS08255	COG2186	Transcriptional regulator
Sa4125_RS08260	COG4213	ABC transporter substrate-binding protein
Sa4125_RS08270	COG4214	carbohydrate transport
Sa4125_RS08285	COG0671	phosphoesterase, PA-phosphatase related
Sa4125_RS08290	COG1335	isochorismatase
Sa4125_RS08310	COG0154	amidase activity
Sa4125_RS08320	COG0725	ABC transporter, periplasmic molybdate-binding protein
Sa4125_RS08325	COG4149	molybdate abc transporter
Sa4125_RS08330	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Sa4125_RS08340	COG3842	ATPase activity
Sa4125_RS08405	COG0243	molybdopterin cofactor binding
Sa4125_RS08405	COG3383	formate dehydrogenase (NAD+) activity
Sa4125_RS08410	COG0437	4 iron, 4 sulfur cluster binding
Sa4125_RS08435	COG0303	'Molybdopterin
Sa4125_RS08445	COG0746	molybdenum cofactor guanylyltransferase activity
Sa4125_RS08450	COG0303	'Molybdopterin
Sa4125_RS08465	COG3842	ATPase activity
Sa4125_RS08485	COG0840	transmembrane signaling receptor activity
Sa4125_RS08490	COG0657	acetylesterase activity
Sa4125_RS08510	COG4172	Belongs to the ABC transporter superfamily
Sa4125_RS08515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa4125_RS08525	COG0747	negative chemotaxis
Sa4125_RS08530	COG4977	sequence-specific DNA binding
Sa4125_RS08540	COG1250	3-hydroxyacyl-CoA dehydrogenase
Sa4125_RS08540	COG0824	Thioesterase
Sa4125_RS08595	COG1272	protein, Hemolysin III
Sa4125_RS08625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Sa4125_RS08645	COG1335	isochorismatase
Sa4125_RS08650	COG3845	ABC transporter
Sa4125_RS08660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Sa4125_RS08665	COG1079	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS08690	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Sa4125_RS08695	COG1917	Cupin 2, conserved barrel domain protein
Sa4125_RS08695	COG1396	sequence-specific DNA binding
Sa4125_RS08705	COG3842	ATPase activity
Sa4125_RS08710	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sa4125_RS08715	COG1177	transmembrane transport
Sa4125_RS08765	COG0745	RESPONSE REGULATOR receiver
Sa4125_RS08780	COG2433	Pfam Transposase IS66
Sa4125_RS08785	COG3436	PFAM IS66 Orf2 family protein
Sa4125_RS08790	COG2963	transposase activity
Sa4125_RS08800	COG3328	transposase activity
Sa4125_RS08820	COG3328	transposase activity
Sa4125_RS08845	COG0789	Transcriptional regulator
Sa4125_RS08860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Sa4125_RS08870	COG3034	peptidoglycan biosynthetic process
Sa4125_RS08885	COG3328	transposase activity
Sa4125_RS08920	COG2847	Copper chaperone PCu(A)C
Sa4125_RS08925	COG1999	signal sequence binding
Sa4125_RS08945	COG1914	H( )-stimulated, divalent metal cation uptake system
Sa4125_RS08950	COG1742	UPF0060 membrane protein
Sa4125_RS08970	COG1238	metal cluster binding
Sa4125_RS08975	COG2814	Major facilitator Superfamily
Sa4125_RS08980	COG1937	Protein conserved in bacteria
Sa4125_RS09030	COG3706	GGDEF domain
Sa4125_RS09030	COG4251	negative regulation of phosphorylation
Sa4125_RS09030	COG5001	Diguanylate cyclase
Sa4125_RS09030	COG2203	Gaf domain
Sa4125_RS09035	COG5001	Diguanylate cyclase
Sa4125_RS09045	COG3328	transposase activity
Sa4125_RS09100	COG2217	Heavy metal translocating P-type atpase
Sa4125_RS09105	COG0789	Transcriptional regulator
Sa4125_RS09175	COG3328	transposase activity
Sa4125_RS09205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Sa4125_RS09210	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Sa4125_RS09215	COG1058	Belongs to the CinA family
Sa4125_RS09215	COG1546	Belongs to the CinA family
Sa4125_RS09220	COG0655	NAD(P)H dehydrogenase (quinone) activity
Sa4125_RS09235	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Sa4125_RS09240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Sa4125_RS09245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Sa4125_RS09260	COG0686	Belongs to the AlaDH PNT family
Sa4125_RS09265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Sa4125_RS09275	COG3328	transposase activity
Sa4125_RS09310	COG3639	organic phosphonate transmembrane transporter activity
Sa4125_RS09315	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Sa4125_RS09330	COG1840	ABC-type Fe3 transport system, periplasmic component
Sa4125_RS09340	COG3842	ATPase activity
Sa4125_RS09345	COG0483	inositol monophosphate 1-phosphatase activity
Sa4125_RS09355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Sa4125_RS09380	COG0129	dihydroxy-acid dehydratase activity
Sa4125_RS09395	COG0316	Belongs to the HesB IscA family
Sa4125_RS09400	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Sa4125_RS09405	COG0018	arginyl-trna synthetase
Sa4125_RS09420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Sa4125_RS09430	COG0805	protein transport
Sa4125_RS09435	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Sa4125_RS09440	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Sa4125_RS09445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Sa4125_RS09460	COG1862	Preprotein translocase
Sa4125_RS09480	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Sa4125_RS09495	COG0544	peptidyl-prolyl cis-trans isomerase activity
Sa4125_RS09500	COG0668	transmembrane transport
Sa4125_RS09505	COG0740	serine-type endopeptidase activity
Sa4125_RS09510	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Sa4125_RS09520	COG0776	regulation of translation
Sa4125_RS09525	COG2814	Major facilitator Superfamily
Sa4125_RS09535	COG2423	ornithine cyclodeaminase activity
Sa4125_RS09545	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
Sa4125_RS09565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa4125_RS09575	COG2267	carboxylic ester hydrolase activity
Sa4125_RS09585	COG0683	leucine binding
Sa4125_RS09595	COG0667	Aldo Keto reductase
Sa4125_RS09620	COG0559	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS09630	COG0667	Aldo Keto reductase
Sa4125_RS09645	COG1177	transmembrane transport
Sa4125_RS09650	COG3842	ATPase activity
Sa4125_RS09660	COG2226	methyltransferase
Sa4125_RS09680	COG1960	acyl-CoA dehydrogenase activity
Sa4125_RS09700	COG3665	Urea carboxylase-associated protein
Sa4125_RS09720	COG1793	dna ligase
Sa4125_RS09725	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS09735	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS09740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa4125_RS09750	COG1082	Xylose isomerase domain protein TIM barrel
Sa4125_RS09760	COG1175	transmembrane transport
Sa4125_RS09775	COG1063	alcohol dehydrogenase
Sa4125_RS09780	COG3842	ATPase activity
Sa4125_RS09785	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS09790	COG1879	ABC-type sugar transport system periplasmic component
Sa4125_RS09810	COG1940	carbohydrate kinase activity
Sa4125_RS09825	COG0673	inositol 2-dehydrogenase activity
Sa4125_RS09830	COG1940	carbohydrate kinase activity
Sa4125_RS09835	COG3842	ATPase activity
Sa4125_RS09840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Sa4125_RS09845	COG0395	ABC-type sugar transport system, permease component
Sa4125_RS09850	COG1175	transmembrane transport
Sa4125_RS09865	COG1349	DNA-binding transcription factor activity
Sa4125_RS09870	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
Sa4125_RS09890	COG3158	transport of potassium into the cell
Sa4125_RS09900	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sa4125_RS09905	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sa4125_RS09910	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sa4125_RS09920	COG0649	NAD binding
Sa4125_RS09930	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Sa4125_RS09935	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Sa4125_RS09955	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Sa4125_RS09965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sa4125_RS09975	COG0713	ATP synthesis coupled electron transport
Sa4125_RS09990	COG1007	ATP synthesis coupled electron transport
Sa4125_RS10005	COG0346	lactoylglutathione lyase activity
Sa4125_RS10015	COG0442	prolyl-tRNA aminoacylation
Sa4125_RS10025	COG1136	(ABC) transporter
Sa4125_RS10040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Sa4125_RS10055	COG0784	Response regulator, receiver
Sa4125_RS10065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Sa4125_RS10085	COG0557	exoribonuclease II activity
Sa4125_RS10090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Sa4125_RS10100	COG0758	DNA mediated transformation
Sa4125_RS10105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Sa4125_RS10110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Sa4125_RS10130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Sa4125_RS10135	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Sa4125_RS10140	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Sa4125_RS10165	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Sa4125_RS10185	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Sa4125_RS10195	COG0511	ligase activity, forming carbon-carbon bonds
Sa4125_RS10205	COG0501	Belongs to the peptidase M48B family
Sa4125_RS10210	COG0436	Aminotransferase
Sa4125_RS10215	COG1530	ribonuclease E activity
Sa4125_RS10220	COG0860	N-Acetylmuramoyl-L-alanine amidase
Sa4125_RS10235	COG0739	heme binding
Sa4125_RS10245	COG2833	Protein of unknown function (DUF455)
Sa4125_RS10250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Sa4125_RS10260	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Sa4125_RS10265	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Sa4125_RS10270	COG2945	thiolester hydrolase activity
Sa4125_RS10275	COG1104	cysteine desulfurase activity
Sa4125_RS10280	COG0719	Fe-S assembly protein
Sa4125_RS10290	COG0396	ATPase activity
Sa4125_RS10295	COG0719	Fe-S assembly protein
Sa4125_RS10300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Sa4125_RS10305	COG2151	metal-sulfur cluster biosynthetic enzyme
Sa4125_RS10310	COG0316	Belongs to the HesB IscA family
Sa4125_RS10330	COG0187	DNA topoisomerase II activity
Sa4125_RS10355	COG2095	MarC family integral membrane protein
Sa4125_RS10360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Sa4125_RS10365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Sa4125_RS10380	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Sa4125_RS10385	COG0343	queuine tRNA-ribosyltransferase activity
Sa4125_RS10410	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Sa4125_RS10415	COG2354	Protein conserved in bacteria
Sa4125_RS10425	COG0582	viral genome integration into host DNA
Sa4125_RS10480	COG0270	DNA (cytosine-5-)-methyltransferase activity
Sa4125_RS10490	COG0785	Cytochrome C biogenesis protein
Sa4125_RS10495	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Sa4125_RS10500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Sa4125_RS10515	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Sa4125_RS10525	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Sa4125_RS10535	COG4166	transmembrane transport
Sa4125_RS10550	COG0679	Auxin Efflux Carrier
Sa4125_RS10555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Sa4125_RS10560	COG1183	phosphatidylcholine synthase activity
Sa4125_RS10575	COG1295	ribonuclease BN
Sa4125_RS10595	COG3707	response regulator
Sa4125_RS10610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Sa4125_RS10615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_RS10620	COG1116	anion transmembrane transporter activity
Sa4125_RS10625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Sa4125_RS10630	COG2146	nitrite reductase [NAD(P)H] activity
Sa4125_RS10635	COG0243	molybdopterin cofactor binding
Sa4125_RS10640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Sa4125_RS10640	COG1648	precorrin-2 dehydrogenase activity
Sa4125_RS10655	COG1238	metal cluster binding
Sa4125_RS10690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sa4125_RS10690	COG3453	Protein conserved in bacteria
Sa4125_RS10695	COG0730	response to heat
Sa4125_RS10700	COG2391	methyltransferase activity
Sa4125_RS10710	COG0640	Transcriptional regulator
Sa4125_RS10715	COG1477	protein flavinylation
Sa4125_RS10755	COG3328	transposase activity
Sa4125_RS10765	COG3443	Belongs to the bacterial solute-binding protein 9 family
Sa4125_RS10770	COG0803	Belongs to the bacterial solute-binding protein 9 family
Sa4125_RS10785	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Sa4125_RS10795	COG0321	lipoyl(octanoyl) transferase activity
Sa4125_RS10795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Sa4125_RS10800	COG0084	hydrolase, TatD family'
Sa4125_RS10815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Sa4125_RS10820	COG1686	Belongs to the peptidase S11 family
Sa4125_RS10855	COG2433	Pfam Transposase IS66
Sa4125_RS10860	COG3436	PFAM IS66 Orf2 family protein
Sa4125_RS10865	COG2963	transposase activity
Sa4125_RS10885	COG3920	Histidine kinase
Sa4125_RS10900	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Sa4125_RS10905	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Sa4125_RS10920	COG2205	protein histidine kinase activity
Sa4125_RS10925	COG0745	RESPONSE REGULATOR receiver
Sa4125_RS10970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Sa4125_RS10980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Sa4125_RS10985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Sa4125_RS10995	COG3956	TIGRFAM MazG family protein
Sa4125_RS11000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Sa4125_RS11005	COG1923	regulation of RNA biosynthetic process
Sa4125_RS11010	COG2204	response regulator
Sa4125_RS11015	COG5000	phosphorelay sensor kinase activity
Sa4125_RS11020	COG2204	response regulator
Sa4125_RS11025	COG3852	Histidine kinase
Sa4125_RS11035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Sa4125_RS11035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Sa4125_RS11040	COG1058	Belongs to the CinA family
Sa4125_RS11040	COG1546	Belongs to the CinA family
Sa4125_RS11045	COG2867	negative regulation of translational initiation
Sa4125_RS11050	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Sa4125_RS11060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Sa4125_RS11070	COG0508	dehydrogenase complex catalyzes the overall conversion of
Sa4125_RS11075	COG0508	dehydrogenase complex catalyzes the overall conversion of
Sa4125_RS11075	COG0022	dehydrogenase e1 component
Sa4125_RS11080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Sa4125_RS11085	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Sa4125_RS11090	COG2116	formate transmembrane transporter activity
Sa4125_RS11095	COG0148	phosphopyruvate hydratase activity
Sa4125_RS11105	COG0504	CTP synthase activity
Sa4125_RS11115	COG0149	triose-phosphate isomerase activity
Sa4125_RS11120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Sa4125_RS11125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Sa4125_RS11130	COG0134	indole-3-glycerol-phosphate synthase activity
Sa4125_RS11135	COG0315	cyclic pyranopterin monophosphate synthase activity
Sa4125_RS11140	COG0303	'Molybdopterin
Sa4125_RS11145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Sa4125_RS11160	COG0372	Belongs to the citrate synthase family
Sa4125_RS11165	COG0629	single-stranded DNA binding
Sa4125_RS11170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Sa4125_RS11190	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Sa4125_RS11190	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Sa4125_RS11195	COG0347	Belongs to the P(II) protein family
Sa4125_RS11200	COG0174	glutamine synthetase
Sa4125_RS11205	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Sa4125_RS11215	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Sa4125_RS11220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Sa4125_RS11225	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Sa4125_RS11230	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Sa4125_RS11235	COG0750	zinc metalloprotease
Sa4125_RS11245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Sa4125_RS11255	COG0528	UMP kinase activity
Sa4125_RS11260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Sa4125_RS11265	COG0052	Belongs to the universal ribosomal protein uS2 family
Sa4125_RS11290	COG0537	adenosine 5'-monophosphoramidase activity
Sa4125_RS11310	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Sa4125_RS11315	COG1686	Belongs to the peptidase S11 family
Sa4125_RS11360	COG2197	response regulator
Sa4125_RS11385	COG1222	aaa ATPase
Sa4125_RS11430	COG3328	transposase activity
Sa4125_RS11470	COG2239	Acts as a magnesium transporter
Sa4125_RS11485	COG0321	lipoyl(octanoyl) transferase activity
Sa4125_RS11490	COG1254	Belongs to the acylphosphatase family
Sa4125_RS11495	COG4770	biotin carboxylase activity
Sa4125_RS11505	COG1671	Belongs to the UPF0178 family
Sa4125_RS11510	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
Sa4125_RS11515	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Sa4125_RS11520	COG3706	GGDEF domain
Sa4125_RS11525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Sa4125_RS11535	COG0546	phosphoglycolate phosphatase activity
Sa4125_RS11545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Sa4125_RS11555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Sa4125_RS11565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sa4125_RS11570	COG0203	ribosomal protein L17
Sa4125_RS11580	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Sa4125_RS11585	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Sa4125_RS11590	COG0563	adenylate kinase activity
Sa4125_RS11600	COG0200	Binds to the 23S rRNA
Sa4125_RS11605	COG1841	ribosomal large subunit assembly
Sa4125_RS11610	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Sa4125_RS11615	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Sa4125_RS11630	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Sa4125_RS11635	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Sa4125_RS11640	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Sa4125_RS11645	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Sa4125_RS11650	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Sa4125_RS11660	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Sa4125_RS11675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Sa4125_RS11685	COG0089	rRNA binding
Sa4125_RS11690	COG0088	Forms part of the polypeptide exit tunnel
Sa4125_RS11705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Sa4125_RS11710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Sa4125_RS11715	COG0049	tRNA binding
Sa4125_RS11720	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Sa4125_RS11725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Sa4125_RS11730	COG0085	RNA polymerase activity
Sa4125_RS11735	COG0222	ribosome binding
Sa4125_RS11740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Sa4125_RS11745	COG0081	regulation of translation
Sa4125_RS11750	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Sa4125_RS11790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Sa4125_RS11805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Sa4125_RS11815	COG0735	belongs to the Fur family
Sa4125_RS11820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Sa4125_RS11825	COG1121	(ABC) transporter
Sa4125_RS11845	COG1959	2 iron, 2 sulfur cluster binding
Sa4125_RS11850	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sa4125_RS11855	COG0673	inositol 2-dehydrogenase activity
Sa4125_RS11865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa4125_RS11870	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS11875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Sa4125_RS11880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sa4125_RS11885	COG1079	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS11890	COG4603	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS11895	COG3845	ABC transporter
Sa4125_RS11910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Sa4125_RS11925	COG1250	3-hydroxyacyl-CoA dehydrogenase
Sa4125_RS11930	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Sa4125_RS11935	COG0235	Class ii aldolase
Sa4125_RS11960	COG0596	Alpha beta hydrolase
Sa4125_RS11960	COG2945	thiolester hydrolase activity
Sa4125_RS11965	COG2188	Transcriptional regulator
Sa4125_RS11975	COG3328	transposase activity
Sa4125_RS11995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_RS12010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Sa4125_RS12035	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS12045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa4125_RS12055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sa4125_RS12060	COG0765	amino acid transport
Sa4125_RS12065	COG0765	amino acid transport
Sa4125_RS12085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_RS12090	COG1116	anion transmembrane transporter activity
Sa4125_RS12100	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS12120	COG0402	S-adenosylhomocysteine deaminase activity
Sa4125_RS12135	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sa4125_RS12140	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sa4125_RS12145	COG3842	ATPase activity
Sa4125_RS12150	COG0402	S-adenosylhomocysteine deaminase activity
Sa4125_RS12180	COG3706	GGDEF domain
Sa4125_RS12205	COG2358	TRAP transporter, solute receptor (TAXI family
Sa4125_RS12220	COG3328	transposase activity
Sa4125_RS12240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Sa4125_RS12245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Sa4125_RS12275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Sa4125_RS12295	COG0302	gtp cyclohydrolase
Sa4125_RS12300	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Sa4125_RS12305	COG1752	Esterase of the alpha-beta hydrolase superfamily
Sa4125_RS12310	COG0516	GMP reductase activity
Sa4125_RS12310	COG0517	IMP dehydrogenase activity
Sa4125_RS12360	COG0628	permease
Sa4125_RS12365	COG1126	abc transporter atp-binding protein
Sa4125_RS12370	COG0765	amino acid transport
Sa4125_RS12375	COG4597	amino acid ABC transporter
Sa4125_RS12380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sa4125_RS12385	COG0626	cystathionine gamma-synthase activity
Sa4125_RS12390	COG2824	Alkylphosphonate utilization operon protein PhnA
Sa4125_RS12505	COG3328	transposase activity
Sa4125_RS12520	COG4381	Mu-like prophage protein gp46
Sa4125_RS12675	COG3328	transposase activity
Sa4125_RS12725	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Sa4125_RS12835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sa4125_RS12860	COG0346	lactoylglutathione lyase activity
Sa4125_RS12885	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Sa4125_RS12900	COG0436	Aminotransferase
Sa4125_RS12910	COG3243	poly(R)-hydroxyalkanoic acid synthase
Sa4125_RS12915	COG0024	Methionine aminopeptidase
Sa4125_RS12920	COG2003	Belongs to the UPF0758 family
Sa4125_RS12925	COG5425	PFAM Usg family protein
Sa4125_RS12930	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS12940	COG2068	MobA-Related Protein
Sa4125_RS12945	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Sa4125_RS12965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Sa4125_RS12970	COG0683	leucine binding
Sa4125_RS12975	COG3191	aminopeptidase activity
Sa4125_RS12985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Sa4125_RS13000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Sa4125_RS13020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Sa4125_RS13025	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Sa4125_RS13035	COG0047	phosphoribosylformylglycinamidine synthase activity
Sa4125_RS13050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Sa4125_RS13065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Sa4125_RS13070	COG2814	Major facilitator Superfamily
Sa4125_RS13075	COG0483	inositol monophosphate 1-phosphatase activity
Sa4125_RS13080	COG0037	tRNA processing
Sa4125_RS13085	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Sa4125_RS13100	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Sa4125_RS13110	COG0538	isocitrate dehydrogenase activity
Sa4125_RS13120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Sa4125_RS13130	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Sa4125_RS13130	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Sa4125_RS13135	COG2313	pseudouridylate synthase activity
Sa4125_RS13160	COG3106	COG3106 Predicted ATPase
Sa4125_RS13165	COG3768	UPF0283 membrane protein
Sa4125_RS13175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Sa4125_RS13180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Sa4125_RS13190	COG0633	Ferredoxin
Sa4125_RS13205	COG3755	Protein conserved in bacteria
Sa4125_RS13210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Sa4125_RS13210	COG3218	ABC-type transport auxiliary lipoprotein component
Sa4125_RS13220	COG1127	ABC transporter
Sa4125_RS13230	COG4948	Mandelate Racemase Muconate Lactonizing
Sa4125_RS13235	COG0438	transferase activity, transferring glycosyl groups
Sa4125_RS13245	COG0280	phosphate acetyltransferase
Sa4125_RS13245	COG0281	malic enzyme
Sa4125_RS13285	COG3328	transposase activity
Sa4125_RS13290	COG3384	dioxygenase
Sa4125_RS13295	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Sa4125_RS13315	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Sa4125_RS13335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sa4125_RS13335	COG2205	protein histidine kinase activity
Sa4125_RS13375	COG1228	amidohydrolase
Sa4125_RS13410	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS13440	COG0252	asparaginase activity
Sa4125_RS13480	COG0714	Associated with various cellular activities
Sa4125_RS13530	COG2188	Transcriptional regulator
Sa4125_RS13535	COG1063	alcohol dehydrogenase
Sa4125_RS13540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Sa4125_RS13550	COG1177	transmembrane transport
Sa4125_RS13555	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Sa4125_RS13560	COG3842	ATPase activity
Sa4125_RS13565	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS13600	COG2963	transposase activity
Sa4125_RS13610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_RS13615	COG1116	anion transmembrane transporter activity
Sa4125_RS13635	COG0154	amidase activity
Sa4125_RS13655	COG0559	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS13680	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS13685	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS13690	COG1129	ABC transporter
Sa4125_RS13745	COG0644	oxidoreductase
Sa4125_RS13750	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Sa4125_RS13770	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Sa4125_RS13775	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Sa4125_RS13780	COG1429	ligase activity, forming nitrogen-metal bonds
Sa4125_RS13785	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Sa4125_RS13795	COG2814	Major facilitator Superfamily
Sa4125_RS13820	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Sa4125_RS13830	COG0156	8-amino-7-oxononanoate synthase activity
Sa4125_RS13865	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Sa4125_RS13870	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Sa4125_RS13875	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Sa4125_RS13880	COG1063	alcohol dehydrogenase
Sa4125_RS13885	COG0500	methyltransferase
Sa4125_RS13890	COG0142	geranyltranstransferase activity
Sa4125_RS13910	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Sa4125_RS13925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Sa4125_RS13935	COG4566	intracellular signal transduction
Sa4125_RS13940	COG4251	negative regulation of phosphorylation
Sa4125_RS13960	COG2186	Transcriptional regulator
Sa4125_RS13965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Sa4125_RS13970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sa4125_RS13975	COG3938	Belongs to the proline racemase family
Sa4125_RS13995	COG3842	ATPase activity
Sa4125_RS14000	COG0395	ABC-type sugar transport system, permease component
Sa4125_RS14005	COG1175	transmembrane transport
Sa4125_RS14010	COG1653	transport
Sa4125_RS14015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Sa4125_RS14020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sa4125_RS14030	COG1228	amidohydrolase
Sa4125_RS14035	COG2986	histidine ammonia-lyase
Sa4125_RS14070	COG0628	permease
Sa4125_RS14085	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Sa4125_RS14090	COG0351	phosphomethylpyrimidine kinase
Sa4125_RS14115	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Sa4125_RS14155	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Sa4125_RS14165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Sa4125_RS14180	COG0395	ABC-type sugar transport system, permease component
Sa4125_RS14185	COG1175	transmembrane transport
Sa4125_RS14200	COG2308	Evidence 4 Homologs of previously reported genes of
Sa4125_RS14215	COG3706	GGDEF domain
Sa4125_RS14225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Sa4125_RS14240	COG0697	spore germination
Sa4125_RS14260	COG2084	Dehydrogenase
Sa4125_RS14270	COG1522	sequence-specific DNA binding
Sa4125_RS14275	COG0625	glutathione transferase activity
Sa4125_RS14280	COG2205	protein histidine kinase activity
Sa4125_RS14280	COG2202	Pas domain
Sa4125_RS14295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Sa4125_RS14305	COG3328	transposase activity
Sa4125_RS14315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Sa4125_RS14325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Sa4125_RS14345	COG5001	Diguanylate cyclase
Sa4125_RS14350	COG3328	transposase activity
Sa4125_RS14360	COG4176	ABC-type proline glycine betaine transport system permease component
Sa4125_RS14365	COG4175	Glycine betaine
Sa4125_RS14365	COG0517	IMP dehydrogenase activity
Sa4125_RS14380	COG3932	Exopolysaccharide synthesis, ExoD
Sa4125_RS14420	COG1088	dTDP-glucose 4,6-dehydratase activity
Sa4125_RS14435	COG0546	phosphoglycolate phosphatase activity
Sa4125_RS14435	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Sa4125_RS14440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Sa4125_RS14465	COG1177	transmembrane transport
Sa4125_RS14470	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sa4125_RS14475	COG3842	ATPase activity
Sa4125_RS14480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Sa4125_RS14485	COG0583	DNA-binding transcription factor activity
Sa4125_RS14490	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Sa4125_RS14525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Sa4125_RS14530	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Sa4125_RS14535	COG3328	transposase activity
Sa4125_RS14575	COG0367	asparagine synthase
Sa4125_RS14580	COG0189	ligase activity
Sa4125_RS14580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Sa4125_RS14585	COG1363	Peptidase, m42
Sa4125_RS14590	COG0659	secondary active sulfate transmembrane transporter activity
Sa4125_RS14595	COG0589	response to stress
Sa4125_RS14620	COG0640	Transcriptional regulator
Sa4125_RS14635	COG4548	von Willebrand factor, type A
Sa4125_RS14640	COG3328	transposase activity
Sa4125_RS14650	COG0714	Associated with various cellular activities
Sa4125_RS14660	COG2010	Cytochrome c
Sa4125_RS14670	COG3328	transposase activity
Sa4125_RS14725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Sa4125_RS14735	COG3328	transposase activity
Sa4125_RS14750	COG2151	metal-sulfur cluster biosynthetic enzyme
Sa4125_RS14780	COG4172	Belongs to the ABC transporter superfamily
Sa4125_RS14790	COG0601	transmembrane transport
Sa4125_RS14810	COG0251	oxidation-reduction process
Sa4125_RS15240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Sa4125_RS15250	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Sa4125_RS15260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Sa4125_RS15290	COG0440	acetolactate synthase activity
Sa4125_RS15300	COG0028	Belongs to the TPP enzyme family
Sa4125_RS15315	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Sa4125_RS15320	COG0560	Phosphoserine phosphatase
Sa4125_RS15320	COG3830	Belongs to the UPF0237 family
Sa4125_RS15345	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Sa4125_RS15350	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Sa4125_RS15355	COG3920	Histidine kinase
Sa4125_RS15355	COG2202	Pas domain
Sa4125_RS15385	COG2814	Major facilitator Superfamily
Sa4125_RS15395	COG3328	transposase activity
Sa4125_RS15400	COG0784	Response regulator, receiver
Sa4125_RS15400	COG4191	Histidine kinase
Sa4125_RS15435	COG0277	FAD linked oxidase domain protein
Sa4125_RS15445	COG4297	protein containing double-stranded beta helix domain
Sa4125_RS15450	COG0412	Dienelactone hydrolase
Sa4125_RS15455	COG0210	DNA helicase
Sa4125_RS15475	COG2814	Major facilitator Superfamily
Sa4125_RS15485	COG1999	signal sequence binding
Sa4125_RS15490	COG2264	protein methyltransferase activity
Sa4125_RS15500	COG0006	proline dipeptidase activity
Sa4125_RS15510	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Sa4125_RS15565	COG2176	DNA-directed DNA polymerase activity
Sa4125_RS15570	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Sa4125_RS15575	COG0497	DNA recombination
Sa4125_RS15580	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Sa4125_RS15590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Sa4125_RS15595	COG0849	cell division
Sa4125_RS15600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Sa4125_RS15605	COG1181	Belongs to the D-alanine--D-alanine ligase family
Sa4125_RS15615	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Sa4125_RS15620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Sa4125_RS15630	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Sa4125_RS15645	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Sa4125_RS15660	COG0275	rRNA processing
Sa4125_RS15665	COG2001	Belongs to the MraZ family
Sa4125_RS15675	COG3023	N-Acetylmuramoyl-L-alanine amidase
Sa4125_RS15680	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Sa4125_RS15725	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Sa4125_RS15745	COG0154	amidase activity
Sa4125_RS15750	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Sa4125_RS15755	COG2226	methyltransferase
Sa4125_RS15760	COG1720	tRNA m6t6A37 methyltransferase activity
Sa4125_RS15770	COG1597	lipid kinase activity
Sa4125_RS15795	COG0586	Pfam SNARE associated Golgi protein
Sa4125_RS15810	COG3920	Histidine kinase
Sa4125_RS15825	COG2267	carboxylic ester hydrolase activity
Sa4125_RS15870	COG0714	Associated with various cellular activities
Sa4125_RS15885	COG2188	Transcriptional regulator
Sa4125_RS15890	COG3624	Phosphonate C-P lyase system protein PhnG
Sa4125_RS15895	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
Sa4125_RS15900	COG3626	phosphonate metabolism
Sa4125_RS15905	COG1598	PFAM Uncharacterised protein family UPF0150
Sa4125_RS15915	COG3627	carbon phosphorus lyase activity
Sa4125_RS15930	COG4107	phosphonate C-P lyase system protein PhnK
Sa4125_RS15935	COG4778	phosphonate C-P lyase system protein PhnL
Sa4125_RS15950	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Sa4125_RS15955	COG3639	organic phosphonate transmembrane transporter activity
Sa4125_RS15960	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Sa4125_RS15965	COG3454	Phosphonate metabolism
Sa4125_RS15970	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Sa4125_RS15970	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Sa4125_RS15990	COG3158	transport of potassium into the cell
Sa4125_RS16010	COG3328	transposase activity
Sa4125_RS16030	COG1566	PFAM secretion protein HlyD family protein
Sa4125_RS16050	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS16060	COG2094	Belongs to the DNA glycosylase MPG family
Sa4125_RS16065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Sa4125_RS16070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Sa4125_RS16075	COG0546	phosphoglycolate phosphatase activity
Sa4125_RS16080	COG2186	Transcriptional regulator
Sa4125_RS16085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Sa4125_RS16090	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Sa4125_RS16095	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Sa4125_RS16100	COG4191	Histidine kinase
Sa4125_RS16105	COG4566	intracellular signal transduction
Sa4125_RS16110	COG0745	RESPONSE REGULATOR receiver
Sa4125_RS16115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Sa4125_RS16140	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Sa4125_RS16145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sa4125_RS16150	COG4558	Periplasmic binding protein
Sa4125_RS16160	COG4771	TonB-dependent receptor
Sa4125_RS16165	COG2329	Antibiotic biosynthesis monooxygenase
Sa4125_RS16175	COG1129	ABC transporter
Sa4125_RS16180	COG1879	ABC-type sugar transport system periplasmic component
Sa4125_RS16190	COG2113	Glycine betaine
Sa4125_RS16195	COG4175	Glycine betaine
Sa4125_RS16195	COG3448	diguanylate cyclase activity
Sa4125_RS16200	COG4176	ABC-type proline glycine betaine transport system permease component
Sa4125_RS16225	COG1396	sequence-specific DNA binding
Sa4125_RS16230	COG4638	Rieske (2fe-2S)
Sa4125_RS16235	COG0235	Class ii aldolase
Sa4125_RS16245	COG1312	Catalyzes the dehydration of D-mannonate
Sa4125_RS16255	COG3852	Histidine kinase
Sa4125_RS16275	COG0303	'Molybdopterin
Sa4125_RS16280	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Sa4125_RS16295	COG0154	amidase activity
Sa4125_RS16315	COG1850	ribulose-bisphosphate carboxylase activity
Sa4125_RS16320	COG2186	Transcriptional regulator
Sa4125_RS16330	COG4211	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS16335	COG1129	ABC transporter
Sa4125_RS16340	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS16345	COG0287	Prephenate dehydrogenase
Sa4125_RS16350	COG0673	inositol 2-dehydrogenase activity
Sa4125_RS16365	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS16370	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS16385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Sa4125_RS16390	COG2942	2-epimerase
Sa4125_RS16420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_RS16430	COG0154	amidase activity
Sa4125_RS16445	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sa4125_RS16450	COG3842	ATPase activity
Sa4125_RS16485	COG2968	Membrane
Sa4125_RS16495	COG3300	MHYT domain
Sa4125_RS16495	COG5001	Diguanylate cyclase
Sa4125_RS16505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Sa4125_RS16525	COG1380	Effector of murein hydrolase LrgA
Sa4125_RS16530	COG1346	cytolysis
Sa4125_RS16555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Sa4125_RS16560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Sa4125_RS16575	COG0492	ferredoxin-NADP+ reductase activity
Sa4125_RS16595	COG0436	Aminotransferase
Sa4125_RS16610	COG1607	acyl-coa hydrolase
Sa4125_RS16645	COG0556	nucleotide-excision repair
Sa4125_RS16660	COG1278	Cold shock
Sa4125_RS16665	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Sa4125_RS16670	COG1278	Cold shock
Sa4125_RS16680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sa4125_RS16690	COG1846	Transcriptional regulator
Sa4125_RS16695	COG0745	RESPONSE REGULATOR receiver
Sa4125_RS16710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Sa4125_RS16730	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Sa4125_RS16740	COG1496	oxidoreductase activity
Sa4125_RS16745	COG0024	Methionine aminopeptidase
Sa4125_RS16755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Sa4125_RS16760	COG0598	Magnesium transport protein CorA
Sa4125_RS16765	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Sa4125_RS16770	COG0193	aminoacyl-tRNA hydrolase activity
Sa4125_RS16780	COG0012	GTP binding
Sa4125_RS16800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Sa4125_RS16805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Sa4125_RS16805	COG2857	Cytochrome c1
Sa4125_RS16820	COG1132	(ABC) transporter
Sa4125_RS16825	COG1132	(ABC) transporter
Sa4125_RS16830	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Sa4125_RS16840	COG4106	trans-aconitate 2-methyltransferase activity
Sa4125_RS16845	COG3047	cAMP biosynthetic process
Sa4125_RS16855	COG0408	coproporphyrinogen oxidase activity
Sa4125_RS16865	COG0617	tRNA 3'-terminal CCA addition
Sa4125_RS16880	COG0714	Associated with various cellular activities
Sa4125_RS16905	COG0435	Glutathione S-transferase
Sa4125_RS16920	COG3135	benzoate transporter
Sa4125_RS16930	COG0508	dehydrogenase complex catalyzes the overall conversion of
Sa4125_RS16930	COG0596	Alpha beta hydrolase
Sa4125_RS16935	COG0028	Belongs to the TPP enzyme family
Sa4125_RS16940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Sa4125_RS16945	COG3920	Histidine kinase
Sa4125_RS16950	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Sa4125_RS16955	COG0512	Glutamine amidotransferase of anthranilate synthase
Sa4125_RS16955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Sa4125_RS16960	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Sa4125_RS16965	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Sa4125_RS16970	COG1733	regulation of RNA biosynthetic process
Sa4125_RS16985	COG5507	3-demethylubiquinone-9 3-methyltransferase
Sa4125_RS17020	COG4175	Glycine betaine
Sa4125_RS17025	COG4608	Belongs to the ABC transporter superfamily
Sa4125_RS17030	COG0444	Belongs to the ABC transporter superfamily
Sa4125_RS17040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa4125_RS17045	COG0601	transmembrane transport
Sa4125_RS17055	COG0747	negative chemotaxis
Sa4125_RS17060	COG0489	protein tyrosine kinase activity
Sa4125_RS17080	COG2202	Pas domain
Sa4125_RS17080	COG3920	Histidine kinase
Sa4125_RS17085	COG0784	Response regulator, receiver
Sa4125_RS17120	COG1597	lipid kinase activity
Sa4125_RS17140	COG0488	(ABC) transporter
Sa4125_RS17175	COG3328	transposase activity
Sa4125_RS17185	COG0513	Belongs to the DEAD box helicase family
Sa4125_RS17235	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Sa4125_RS17260	COG4794	Type iii secretion
Sa4125_RS17270	COG5443	negative regulation of bacterial-type flagellum assembly
Sa4125_RS17275	COG5442	Flagellar protein FlaF
Sa4125_RS17320	COG1766	The M ring may be actively involved in energy transduction
Sa4125_RS17335	COG1338	Plays a role in the flagellum-specific transport system
Sa4125_RS17345	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Sa4125_RS17355	COG1706	bacterial-type flagellum-dependent cell motility
Sa4125_RS17365	COG4786	Flagellar basal body rod
Sa4125_RS17370	COG1677	Flagellar hook-basal body complex protein FliE
Sa4125_RS17375	COG1558	bacterial-type flagellum-dependent cell motility
Sa4125_RS17380	COG1815	bacterial-type flagellum-dependent cell motility
Sa4125_RS17385	COG0835	chemotaxis
Sa4125_RS17395	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Sa4125_RS17400	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Sa4125_RS17405	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Sa4125_RS17420	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Sa4125_RS17425	COG4786	Flagellar basal body rod
Sa4125_RS17430	COG1157	protein secretion by the type III secretion system
Sa4125_RS17440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_RS17445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_RS17455	COG1116	anion transmembrane transporter activity
Sa4125_RS17490	COG3328	transposase activity
Sa4125_RS17505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Sa4125_RS17510	COG1309	transcriptional regulator
Sa4125_RS17515	COG3300	MHYT domain
Sa4125_RS17515	COG5001	Diguanylate cyclase
Sa4125_RS17525	COG0493	'glutamate synthase
Sa4125_RS17565	COG0251	oxidation-reduction process
Sa4125_RS17570	COG0300	oxidoreductase activity
Sa4125_RS17580	COG1218	3'(2'),5'-bisphosphate nucleotidase
Sa4125_RS17595	COG1863	multisubunit Na H antiporter MnhE subunit
Sa4125_RS17600	COG0651	ATP synthesis coupled electron transport
Sa4125_RS17605	COG1006	Multisubunit Na H antiporter MnhC subunit
Sa4125_RS17610	COG2111	Na H antiporter
Sa4125_RS17615	COG2111	Na H antiporter
Sa4125_RS17615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Sa4125_RS17625	COG2010	Cytochrome c
Sa4125_RS17635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Sa4125_RS17650	COG1376	ErfK ybiS ycfS ynhG family protein
Sa4125_RS17660	COG0433	COG0433 Predicted ATPase
Sa4125_RS17670	COG3920	Histidine kinase
Sa4125_RS17715	COG0535	radical SAM domain protein
Sa4125_RS17725	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
Sa4125_RS17730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Sa4125_RS17740	COG1703	isobutyryl-CoA mutase activity
Sa4125_RS17790	COG1830	Aldolase
Sa4125_RS17800	COG3328	transposase activity
Sa4125_RS17825	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Sa4125_RS17830	COG3657	addiction module killer protein
Sa4125_RS17840	COG0446	pyridine nucleotide-disulphide oxidoreductase
Sa4125_RS17840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Sa4125_RS17850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sa4125_RS17890	COG0693	protein deglycase activity
Sa4125_RS17905	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Sa4125_RS17930	COG0583	DNA-binding transcription factor activity
Sa4125_RS17940	COG3153	acetyltransferase
Sa4125_RS17950	COG0523	cobalamin synthesis protein
Sa4125_RS17965	COG1609	Transcriptional regulator
Sa4125_RS17970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Sa4125_RS17990	COG0800	Aldolase
Sa4125_RS17995	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Sa4125_RS18015	COG3119	arylsulfatase activity
Sa4125_RS18020	COG3328	transposase activity
Sa4125_RS18030	COG0318	PFAM AMP-dependent synthetase and ligase
Sa4125_RS18085	COG0667	Aldo Keto reductase
Sa4125_RS18100	COG1376	ErfK ybiS ycfS ynhG family protein
Sa4125_RS18105	COG2081	HI0933 family
Sa4125_RS18110	COG0531	amino acid
Sa4125_RS18115	COG0542	response to heat
Sa4125_RS18125	COG2890	protein-(glutamine-N5) methyltransferase activity
Sa4125_RS18130	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Sa4125_RS18140	COG0527	aspartate kinase activity
Sa4125_RS18145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Sa4125_RS18180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Sa4125_RS18190	COG1040	competence protein
Sa4125_RS18195	COG2226	methyltransferase
Sa4125_RS18205	COG0494	nUDIX hydrolase
Sa4125_RS18215	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Sa4125_RS18220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Sa4125_RS18225	COG0653	protein targeting
Sa4125_RS18230	COG3034	peptidoglycan biosynthetic process
Sa4125_RS18235	COG0825	malonyl-CoA metabolic process
Sa4125_RS18240	COG4974	Belongs to the 'phage' integrase family
Sa4125_RS18255	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Sa4125_RS18290	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Sa4125_RS18295	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Sa4125_RS18305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Sa4125_RS18310	COG0697	spore germination
Sa4125_RS18320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sa4125_RS18330	COG0667	Aldo Keto reductase
Sa4125_RS18335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Sa4125_RS18340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Sa4125_RS18350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Sa4125_RS18355	COG0287	Prephenate dehydrogenase
Sa4125_RS18385	COG2884	Cell division ATP-binding protein ftsE
Sa4125_RS18405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Sa4125_RS18410	COG0165	Argininosuccinate lyase
Sa4125_RS18420	COG0019	diaminopimelate decarboxylase activity
Sa4125_RS18430	COG4106	trans-aconitate 2-methyltransferase activity
Sa4125_RS18435	COG1250	3-hydroxyacyl-CoA dehydrogenase
Sa4125_RS18440	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Sa4125_RS18445	COG2086	electron transfer activity
Sa4125_RS18455	COG1511	domain protein
Sa4125_RS18455	COG3264	Mechanosensitive ion channel
Sa4125_RS18460	COG2096	Adenosyltransferase
Sa4125_RS18480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Sa4125_RS18525	COG0523	cobalamin synthesis protein
Sa4125_RS18530	COG1686	Belongs to the peptidase S11 family
Sa4125_RS18535	COG1473	amidohydrolase
Sa4125_RS18570	COG0673	inositol 2-dehydrogenase activity
Sa4125_RS18590	COG1175	transmembrane transport
Sa4125_RS18600	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Sa4125_RS18605	COG2971	BadF BadG BcrA BcrD
Sa4125_RS18610	COG2188	Transcriptional regulator
Sa4125_RS18615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Sa4125_RS18620	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Sa4125_RS18625	COG3842	ATPase activity
Sa4125_RS18640	COG0643	Histidine kinase
Sa4125_RS18640	COG2198	Histidine kinase
Sa4125_RS18650	COG0745	RESPONSE REGULATOR receiver
Sa4125_RS18655	COG0745	RESPONSE REGULATOR receiver
Sa4125_RS18665	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Sa4125_RS18670	COG1120	ATPase activity
Sa4125_RS18675	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sa4125_RS18680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sa4125_RS18685	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Sa4125_RS18695	COG3034	peptidoglycan biosynthetic process
Sa4125_RS18750	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Sa4125_RS18755	COG0431	NADPH-dependent FMN reductase
Sa4125_RS18805	COG3318	Belongs to the UPF0149 family
Sa4125_RS18805	COG3012	SEC-C Motif Domain Protein
Sa4125_RS18820	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Sa4125_RS18835	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS18840	COG0183	Belongs to the thiolase family
Sa4125_RS18850	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Sa4125_RS18855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Sa4125_RS18860	COG0142	geranyltranstransferase activity
Sa4125_RS18880	COG0741	lytic transglycosylase activity
Sa4125_RS18880	COG1196	nuclear chromosome segregation
Sa4125_RS18880	COG0739	heme binding
Sa4125_RS18900	COG1349	DNA-binding transcription factor activity
Sa4125_RS18905	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Sa4125_RS18920	COG0673	inositol 2-dehydrogenase activity
Sa4125_RS18935	COG1640	4-alpha-glucanotransferase
Sa4125_RS18940	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Sa4125_RS18955	COG2308	Evidence 4 Homologs of previously reported genes of
Sa4125_RS18955	COG2307	Protein conserved in bacteria
Sa4125_RS18965	COG3706	GGDEF domain
Sa4125_RS18980	COG0366	Alpha amylase catalytic
Sa4125_RS18985	COG0179	Fumarylacetoacetate (FAA) hydrolase
Sa4125_RS18995	COG0402	S-adenosylhomocysteine deaminase activity
Sa4125_RS19010	COG1079	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS19015	COG4603	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS19020	COG3845	ABC transporter
Sa4125_RS19030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Sa4125_RS19040	COG2351	hydroxyisourate hydrolase activity
Sa4125_RS19060	COG4266	Belongs to the allantoicase family
Sa4125_RS19065	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
Sa4125_RS19080	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Sa4125_RS19085	COG0830	nickel cation binding
Sa4125_RS19090	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Sa4125_RS19110	COG0804	urea catabolic process
Sa4125_RS19125	COG0832	Belongs to the urease beta subunit family
Sa4125_RS19140	COG0831	urea catabolic process
Sa4125_RS19155	COG1137	ATPase activity
Sa4125_RS19165	COG0559	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS19185	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
Sa4125_RS19190	COG1229	Formylmethanofuran dehydrogenase subunit A
Sa4125_RS19195	COG1029	Formylmethanofuran dehydrogenase, subunit B
Sa4125_RS19200	COG2154	pterin-4-alpha-carbinolamine dehydratase
Sa4125_RS19210	COG0702	epimerase
Sa4125_RS19225	COG4067	protein conserved in archaea
Sa4125_RS19225	COG0189	ligase activity
Sa4125_RS19235	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
Sa4125_RS19240	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Sa4125_RS19275	COG0683	leucine binding
Sa4125_RS19285	COG2197	response regulator
Sa4125_RS19365	COG0405	Gamma-glutamyltransferase
Sa4125_RS19370	COG1454	alcohol dehydrogenase
Sa4125_RS19375	COG4948	Mandelate Racemase Muconate Lactonizing
Sa4125_RS19380	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Sa4125_RS19420	COG3328	transposase activity
Sa4125_RS19435	COG4957	zinc ion binding
Sa4125_RS19545	COG2963	transposase activity
Sa4125_RS19550	COG3436	PFAM IS66 Orf2 family protein
Sa4125_RS19555	COG2433	Pfam Transposase IS66
Sa4125_RS19565	COG4191	Histidine kinase
Sa4125_RS19575	COG4566	intracellular signal transduction
Sa4125_RS19590	COG2954	triphosphatase activity
Sa4125_RS19615	COG0443	Heat shock 70 kDa protein
Sa4125_RS19635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Sa4125_RS19635	COG1648	precorrin-2 dehydrogenase activity
Sa4125_RS19640	COG1072	(Pantothenic acid kinase))
Sa4125_RS19650	COG0438	transferase activity, transferring glycosyl groups
Sa4125_RS19655	COG0477	Major facilitator Superfamily
Sa4125_RS19675	COG0488	(ABC) transporter
Sa4125_RS19690	COG0848	biopolymer transport protein
Sa4125_RS19700	COG0179	Fumarylacetoacetate (FAA) hydrolase
Sa4125_RS19705	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS19710	COG5001	Diguanylate cyclase
Sa4125_RS19710	COG3300	MHYT domain
Sa4125_RS19715	COG0235	Class ii aldolase
Sa4125_RS19720	COG1609	Transcriptional regulator
Sa4125_RS19725	COG2084	Dehydrogenase
Sa4125_RS19730	COG3622	Belongs to the hyi family
Sa4125_RS19735	COG3395	kinase activity
Sa4125_RS19740	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS19745	COG3842	ATPase activity
Sa4125_RS19755	COG1175	transmembrane transport
Sa4125_RS19760	COG0395	ABC-type sugar transport system, permease component
Sa4125_RS19780	COG4172	Belongs to the ABC transporter superfamily
Sa4125_RS19790	COG0747	negative chemotaxis
Sa4125_RS19800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa4125_RS19835	COG4251	negative regulation of phosphorylation
Sa4125_RS19840	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Sa4125_RS19850	COG0402	S-adenosylhomocysteine deaminase activity
Sa4125_RS19865	COG0577	efflux transmembrane transporter activity
Sa4125_RS19870	COG1136	(ABC) transporter
Sa4125_RS19875	COG2183	response to ionizing radiation
Sa4125_RS19880	COG0656	L-ascorbic acid biosynthetic process
Sa4125_RS19925	COG0297	glycogen (starch) synthase activity
Sa4125_RS19960	COG0454	-acetyltransferase
Sa4125_RS19960	COG0456	acetyltransferase
Sa4125_RS19985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Sa4125_RS19995	COG0402	S-adenosylhomocysteine deaminase activity
Sa4125_RS20005	COG4608	Belongs to the ABC transporter superfamily
Sa4125_RS20015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa4125_RS20025	COG0747	negative chemotaxis
Sa4125_RS20035	COG2186	Transcriptional regulator
Sa4125_RS20040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Sa4125_RS20055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_RS20075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Sa4125_RS20085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Sa4125_RS20090	COG1609	Transcriptional regulator
Sa4125_RS20105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_RS20110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Sa4125_RS20120	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Sa4125_RS20125	COG1024	Enoyl-CoA hydratase
Sa4125_RS20150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Sa4125_RS20155	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Sa4125_RS20190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Sa4125_RS20200	COG1802	Transcriptional regulator
Sa4125_RS20225	COG0318	PFAM AMP-dependent synthetase and ligase
Sa4125_RS20240	COG3328	transposase activity
Sa4125_RS20245	COG2201	protein-glutamate methylesterase activity
Sa4125_RS20290	COG1846	Transcriptional regulator
Sa4125_RS20315	COG2080	2 iron, 2 sulfur cluster binding
Sa4125_RS20320	COG2010	Cytochrome c
Sa4125_RS20320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Sa4125_RS20340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sa4125_RS20355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_RS20375	COG3328	transposase activity
Sa4125_RS20405	COG1414	Transcriptional regulator
Sa4125_RS20445	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS20455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa4125_RS20470	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS20475	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS20480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa4125_RS20505	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS20520	COG0601	transmembrane transport
Sa4125_RS20525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa4125_RS20535	COG1280	lysine exporter protein (LysE YggA)
Sa4125_RS20545	COG1414	Transcriptional regulator
Sa4125_RS20560	COG3842	ATPase activity
Sa4125_RS20565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Sa4125_RS20580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Sa4125_RS20590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sa4125_RS20595	COG2358	TRAP transporter, solute receptor (TAXI family
Sa4125_RS20605	COG3328	transposase activity
Sa4125_RS20610	COG0582	viral genome integration into host DNA
Sa4125_RS20615	COG3328	transposase activity
Sa4125_RS20655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Sa4125_RS20670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Sa4125_RS20675	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Sa4125_RS20680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Sa4125_RS20685	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Sa4125_RS20690	COG0799	negative regulation of ribosome biogenesis
Sa4125_RS20695	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Sa4125_RS20705	COG0793	Belongs to the peptidase S41A family
Sa4125_RS20720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Sa4125_RS20730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Sa4125_RS20735	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Sa4125_RS20740	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Sa4125_RS20745	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Sa4125_RS20770	COG1252	NADH dehydrogenase
Sa4125_RS20775	COG0783	Belongs to the Dps family
Sa4125_RS20795	COG3328	transposase activity
Sa4125_RS20800	COG3706	GGDEF domain
Sa4125_RS20820	COG1053	succinate dehydrogenase
Sa4125_RS20825	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Sa4125_RS20830	COG2009	succinate dehydrogenase
Sa4125_RS20840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Sa4125_RS20845	COG3546	catalase activity
Sa4125_RS20850	COG0335	large ribosomal subunit rRNA binding
Sa4125_RS20860	COG0336	Belongs to the RNA methyltransferase TrmD family
Sa4125_RS20910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Sa4125_RS20925	COG0840	transmembrane signaling receptor activity
Sa4125_RS20930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Sa4125_RS20935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Sa4125_RS20940	COG0552	protein localization to endoplasmic reticulum
Sa4125_RS20955	COG2917	probably involved in intracellular septation
Sa4125_RS20980	COG3609	addiction module antidote protein, CC2985 family
Sa4125_RS20985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Sa4125_RS20995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Sa4125_RS21000	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Sa4125_RS21005	COG4133	protoheme IX ABC transporter activity
Sa4125_RS21015	COG2910	NAD(P)H-binding
Sa4125_RS21020	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Sa4125_RS21040	COG0670	Belongs to the BI1 family
Sa4125_RS21045	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Sa4125_RS21050	COG4181	ATPase activity
Sa4125_RS21060	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Sa4125_RS21075	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Sa4125_RS21105	COG0137	argininosuccinate synthase activity
Sa4125_RS21110	COG3177	Filamentation induced by cAMP protein fic
Sa4125_RS21120	COG1620	l-lactate permease
Sa4125_RS21125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Sa4125_RS21130	COG0745	RESPONSE REGULATOR receiver
Sa4125_RS21140	COG0243	molybdopterin cofactor binding
Sa4125_RS21170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Sa4125_RS21175	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Sa4125_RS21180	COG0181	hydroxymethylbilane synthase activity
Sa4125_RS21205	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Sa4125_RS21210	COG3300	MHYT domain
Sa4125_RS21210	COG5001	Diguanylate cyclase
Sa4125_RS21240	COG1872	DUF167
Sa4125_RS21245	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Sa4125_RS21250	COG1760	l-serine dehydratase
Sa4125_RS21290	COG1217	gtp-binding protein TYPA
Sa4125_RS21295	COG0339	signal peptide processing
Sa4125_RS21320	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Sa4125_RS21325	COG1674	ftsk spoiiie
Sa4125_RS21335	COG0004	ammonium transporteR
Sa4125_RS21340	COG0347	Belongs to the P(II) protein family
Sa4125_RS21345	COG1946	Acyl-CoA thioesterase
Sa4125_RS21350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Sa4125_RS21360	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Sa4125_RS21370	COG0175	sulfate reduction
Sa4125_RS21375	COG0175	sulfate reduction
Sa4125_RS21400	COG2885	chlorophyll binding
Sa4125_RS21410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Sa4125_RS21435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Sa4125_RS21440	COG0066	3-isopropylmalate dehydratase activity
Sa4125_RS21445	COG0318	PFAM AMP-dependent synthetase and ligase
Sa4125_RS21465	COG3328	transposase activity
Sa4125_RS21485	COG3706	GGDEF domain
Sa4125_RS21490	COG3706	GGDEF domain
Sa4125_RS21495	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Sa4125_RS21505	COG0559	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS21520	COG0683	leucine binding
Sa4125_RS21535	COG2835	tetraacyldisaccharide 4'-kinase activity
Sa4125_RS21565	COG3046	protein related to deoxyribodipyrimidine photolyase
Sa4125_RS21590	COG0346	lactoylglutathione lyase activity
Sa4125_RS21595	COG0400	carboxylic ester hydrolase activity
Sa4125_RS21605	COG0587	DNA-directed DNA polymerase activity
Sa4125_RS21630	COG3328	transposase activity
Sa4125_RS21670	COG1764	response to oxidative stress
Sa4125_RS21700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Sa4125_RS21710	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS21725	COG0508	dehydrogenase complex catalyzes the overall conversion of
Sa4125_RS21735	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Sa4125_RS21750	COG0045	succinate-CoA ligase (ADP-forming) activity
Sa4125_RS21755	COG0039	L-malate dehydrogenase activity
Sa4125_RS21760	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Sa4125_RS21770	COG0288	reversible hydration of carbon dioxide
Sa4125_RS21780	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
Sa4125_RS21790	COG1704	LemA family
Sa4125_RS21795	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
Sa4125_RS21805	COG2902	Dehydrogenase
Sa4125_RS21820	COG0138	bifunctional purine biosynthesis protein purh
Sa4125_RS21840	COG0501	Belongs to the peptidase M48B family
Sa4125_RS21870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Sa4125_RS21890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Sa4125_RS21930	COG0357	Ribosomal RNA small subunit methyltransferase G
Sa4125_RS21940	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Sa4125_RS21945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Sa4125_RS21950	COG4993	Dehydrogenase
Sa4125_RS21955	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Sa4125_RS21960	COG3030	protein affecting phage T7 exclusion by the F plasmid
Sa4125_RS21985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Sa4125_RS21990	COG0237	dephospho-CoA kinase activity
Sa4125_RS22000	COG0424	maF-like protein
Sa4125_RS22005	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Sa4125_RS22040	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Sa4125_RS22045	COG2197	response regulator
Sa4125_RS22050	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Sa4125_RS22060	COG0140	phosphoribosyl-ATP diphosphatase activity
Sa4125_RS22080	COG0539	negative regulation of cytoplasmic translation
Sa4125_RS22090	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Sa4125_RS22120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Sa4125_RS22125	COG0131	Imidazoleglycerol-phosphate dehydratase
Sa4125_RS22135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Sa4125_RS22140	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Sa4125_RS22185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Sa4125_RS22190	COG5001	Diguanylate cyclase
Sa4125_RS22190	COG4251	negative regulation of phosphorylation
Sa4125_RS22190	COG3706	GGDEF domain
Sa4125_RS22190	COG2203	Gaf domain
Sa4125_RS22210	COG1968	undecaprenyl-diphosphatase activity
Sa4125_RS22230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Sa4125_RS22245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Sa4125_RS22270	COG0534	Mate efflux family protein
Sa4125_RS22305	COG1879	ABC-type sugar transport system periplasmic component
Sa4125_RS22310	COG1129	ABC transporter
Sa4125_RS22320	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS22330	COG2721	sulfolactate sulfo-lyase activity
Sa4125_RS22340	COG1162	GTPase activity
Sa4125_RS22350	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Sa4125_RS22365	COG0133	tryptophan synthase activity
Sa4125_RS22405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Sa4125_RS22405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Sa4125_RS22415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Sa4125_RS22425	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Sa4125_RS22430	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Sa4125_RS22440	COG1309	transcriptional regulator
Sa4125_RS22445	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS22455	COG4221	oxidoreductase activity
Sa4125_RS22460	COG0583	DNA-binding transcription factor activity
Sa4125_RS22465	COG1643	Atp-dependent helicase
Sa4125_RS22475	COG4135	transport system, permease component
Sa4125_RS22490	COG4134	Bacterial extracellular solute-binding protein
Sa4125_RS22495	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS22515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Sa4125_RS22520	COG0484	heat shock protein binding
Sa4125_RS22525	COG0443	Heat shock 70 kDa protein
Sa4125_RS22540	COG1376	ErfK ybiS ycfS ynhG family protein
Sa4125_RS22560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Sa4125_RS22640	COG2894	cell division
Sa4125_RS22645	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Sa4125_RS22710	COG3608	succinylglutamate desuccinylase aspartoacylase
Sa4125_RS22715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Sa4125_RS22720	COG3328	transposase activity
Sa4125_RS22775	COG1312	Catalyzes the dehydration of D-mannonate
Sa4125_RS22780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Sa4125_RS22785	COG0625	glutathione transferase activity
Sa4125_RS22800	COG0471	metal ion transport
Sa4125_RS22800	COG3273	potassium ion transport
Sa4125_RS22810	COG3300	MHYT domain
Sa4125_RS22810	COG5001	Diguanylate cyclase
Sa4125_RS22815	COG0667	Aldo Keto reductase
Sa4125_RS22820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Sa4125_RS22830	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS22835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sa4125_RS22845	COG1074	ATP-dependent DNA helicase activity
Sa4125_RS22850	COG2887	Belongs to the helicase family. UvrD subfamily
Sa4125_RS22855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Sa4125_RS22860	COG3178	'Phosphotransferase
Sa4125_RS22865	COG2205	protein histidine kinase activity
Sa4125_RS22870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Sa4125_RS22880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sa4125_RS22885	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sa4125_RS22885	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Sa4125_RS22895	COG2205	protein histidine kinase activity
Sa4125_RS22900	COG0745	RESPONSE REGULATOR receiver
Sa4125_RS22905	COG3871	stress protein (general stress protein 26)
Sa4125_RS22910	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Sa4125_RS22920	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Sa4125_RS22925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sa4125_RS22930	COG0071	Belongs to the small heat shock protein (HSP20) family
Sa4125_RS22940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sa4125_RS22945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Sa4125_RS22950	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Sa4125_RS22955	COG1137	ATPase activity
Sa4125_RS22970	COG0616	signal peptide processing
Sa4125_RS22990	COG0116	Belongs to the methyltransferase superfamily
Sa4125_RS22990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Sa4125_RS23005	COG0604	alcohol dehydrogenase
Sa4125_RS23020	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Sa4125_RS23035	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Sa4125_RS23050	COG0180	Tryptophanyl-tRNA synthetase
Sa4125_RS23070	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Sa4125_RS23075	COG1214	PFAM Peptidase M22, glycoprotease
Sa4125_RS23090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Sa4125_RS23095	COG1702	phosphate starvation-inducible protein PhoH
Sa4125_RS23100	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Sa4125_RS23105	COG1253	flavin adenine dinucleotide binding
Sa4125_RS23115	COG1396	sequence-specific DNA binding
Sa4125_RS23120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Sa4125_RS23125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Sa4125_RS23130	COG0779	Required for maturation of 30S ribosomal subunits
Sa4125_RS23145	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Sa4125_RS23150	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Sa4125_RS23160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Sa4125_RS23165	COG0583	DNA-binding transcription factor activity
Sa4125_RS23175	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Sa4125_RS23180	COG1185	polyribonucleotide nucleotidyltransferase activity
Sa4125_RS23195	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Sa4125_RS23205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Sa4125_RS23215	COG0735	belongs to the Fur family
Sa4125_RS23245	COG1129	ABC transporter
Sa4125_RS23250	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS23255	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS23260	COG3842	ATPase activity
Sa4125_RS23280	COG1175	transmembrane transport
Sa4125_RS23310	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS23315	COG1802	Transcriptional regulator
Sa4125_RS23325	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Sa4125_RS23330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Sa4125_RS23345	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS23350	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_RS23355	COG1129	ABC transporter
Sa4125_RS23390	COG0511	ligase activity, forming carbon-carbon bonds
Sa4125_RS23390	COG5016	pyruvate
Sa4125_RS23395	COG0439	Biotin carboxylase
Sa4125_RS23405	COG1984	allophanate hydrolase subunit 2
Sa4125_RS23435	COG0756	dUTP diphosphatase activity
Sa4125_RS23440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Sa4125_RS23455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Sa4125_RS23460	COG2226	methyltransferase
Sa4125_RS23465	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Sa4125_RS23470	COG1024	Enoyl-CoA hydratase
Sa4125_RS23475	COG0268	Binds directly to 16S ribosomal RNA
Sa4125_RS23520	COG1960	acyl-CoA dehydrogenase activity
Sa4125_RS23545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Sa4125_RS23550	COG1012	belongs to the aldehyde dehydrogenase family
Sa4125_RS23555	COG2086	electron transfer activity
Sa4125_RS23560	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Sa4125_RS23565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sa4125_RS23570	COG1126	abc transporter atp-binding protein
Sa4125_RS23575	COG0765	amino acid transport
Sa4125_RS23580	COG0765	amino acid transport
Sa4125_RS23585	COG2721	sulfolactate sulfo-lyase activity
Sa4125_RS23610	COG4770	biotin carboxylase activity
Sa4125_RS23615	COG3842	ATPase activity
Sa4125_RS23635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Sa4125_RS23640	COG1177	transmembrane transport
Sa4125_RS23655	COG2030	dehydratase
Sa4125_RS23660	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_RS23670	COG3505	Type IV secretory pathway VirD4
Sa4125_RS23700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Sa4125_RS23745	COG3701	Conjugal transfer protein
Sa4125_RS23750	COG3846	protein secretion by the type IV secretion system
Sa4125_RS23760	COG5314	conjugation
Sa4125_RS23765	COG3451	type IV secretory pathway VirB4
Sa4125_RS23770	COG5268	conjugation
Sa4125_RS23780	COG4962	Type ii secretion system protein e
Sa4125_RS23785	COG3916	Acyl-homoserine-lactone synthase
Sa4125_RS23790	COG1192	Involved in chromosome partitioning
Sa4125_RS23795	COG1475	DNA binding
Sa4125_RS23800	COG1414	Transcriptional regulator
Sa4125_RS23825	COG3328	transposase activity
Sa4125_RS23855	COG2944	sequence-specific DNA binding
Sa4125_RS23865	COG1475	DNA binding
Sa4125_RS23880	COG4644	lycopene metabolic process
Sa4125_RS23885	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Sa4125_RS23905	COG3657	addiction module killer protein
Sa4125_RS23930	COG2203	Gaf domain
Sa4125_RS23930	COG3706	GGDEF domain
Sa4125_RS23930	COG4251	negative regulation of phosphorylation
Sa4125_RS23930	COG5001	Diguanylate cyclase
Sa4125_RS23945	COG5001	Diguanylate cyclase
Sa4125_RS23950	COG2963	transposase activity
Sa4125_RS23955	COG3436	PFAM IS66 Orf2 family protein
Sa4125_RS23960	COG2433	Pfam Transposase IS66
Sa4125_RS23985	COG0840	transmembrane signaling receptor activity
Sa4125_RS24030	COG5489	Protein of unknown function (DUF736)
Sa4125_RS24040	COG3831	ATPase activity
Sa4125_RS24050	COG0583	DNA-binding transcription factor activity
Sa4125_RS24090	COG0464	growth
Sa4125_RS24170	COG1802	Transcriptional regulator