locus-tag	class	description
C5O00_RS00005	COG4946	Tricorn protease homolog
C5O00_RS00005	COG0823	Involved in the tonB-independent uptake of proteins
C5O00_RS00005	COG1506	peptidase
C5O00_RS00015	COG1652	LysM domain
C5O00_RS00085	COG3070	regulator of competence-specific genes
C5O00_RS00135	COG3279	Response regulator of the LytR AlgR family
C5O00_RS00160	COG3275	phosphorelay sensor kinase activity
C5O00_RS00220	COG0494	nUDIX hydrolase
C5O00_RS00225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C5O00_RS00260	COG0714	Associated with various cellular activities
C5O00_RS00320	COG0492	ferredoxin-NADP+ reductase activity
C5O00_RS00335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5O00_RS00355	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C5O00_RS00370	COG0589	response to stress
C5O00_RS00390	COG0589	response to stress
C5O00_RS00395	COG0745	RESPONSE REGULATOR receiver
C5O00_RS00400	COG0784	Response regulator, receiver
C5O00_RS00400	COG2198	Histidine kinase
C5O00_RS00400	COG5002	protein histidine kinase activity
C5O00_RS00420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C5O00_RS00425	COG0589	response to stress
C5O00_RS00505	COG1595	DNA-templated transcription, initiation
C5O00_RS00515	COG0302	gtp cyclohydrolase
C5O00_RS00535	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C5O00_RS00535	COG1333	cytochrome c biogenesis protein
C5O00_RS00540	COG0076	glutamate decarboxylase activity
C5O00_RS00555	COG2133	pyrroloquinoline quinone binding
C5O00_RS00570	COG2010	Cytochrome c
C5O00_RS00575	COG0572	uridine kinase
C5O00_RS00585	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5O00_RS00595	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5O00_RS00595	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5O00_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
C5O00_RS00615	COG1192	Involved in chromosome partitioning
C5O00_RS00620	COG1475	DNA binding
C5O00_RS00630	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C5O00_RS00660	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C5O00_RS00670	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C5O00_RS00680	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C5O00_RS00705	COG2169	Transcriptional regulator
C5O00_RS00710	COG0346	lactoylglutathione lyase activity
C5O00_RS00720	COG0105	UTP biosynthetic process
C5O00_RS00730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C5O00_RS00740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C5O00_RS00745	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5O00_RS00755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5O00_RS00780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5O00_RS00785	COG0501	Belongs to the peptidase M48B family
C5O00_RS00790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5O00_RS00800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C5O00_RS00810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5O00_RS00830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5O00_RS00845	COG3956	TIGRFAM MazG family protein
C5O00_RS00855	COG0242	peptide deformylase activity
C5O00_RS00860	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C5O00_RS00865	COG2171	N-acyltransferase activity
C5O00_RS00905	COG0438	transferase activity, transferring glycosyl groups
C5O00_RS00915	COG0009	L-threonylcarbamoyladenylate synthase
C5O00_RS00920	COG0617	tRNA 3'-terminal CCA addition
C5O00_RS00920	COG0517	IMP dehydrogenase activity
C5O00_RS00920	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C5O00_RS00925	COG1612	heme a metabolic process
C5O00_RS00945	COG1131	(ABC) transporter
C5O00_RS00965	COG0556	nucleotide-excision repair
C5O00_RS00980	COG1187	pseudouridine synthase activity
C5O00_RS00985	COG0071	Belongs to the small heat shock protein (HSP20) family
C5O00_RS01005	COG0045	succinate-CoA ligase (ADP-forming) activity
C5O00_RS01010	COG0019	diaminopimelate decarboxylase activity
C5O00_RS01030	COG1472	Belongs to the glycosyl hydrolase 3 family
C5O00_RS01045	COG1404	Belongs to the peptidase S8 family
C5O00_RS01050	COG0482	sulfurtransferase activity
C5O00_RS01060	COG0706	membrane insertase activity
C5O00_RS01065	COG0504	CTP synthase activity
C5O00_RS01090	COG1388	LysM domain
C5O00_RS01090	COG3942	CHAP domain
C5O00_RS01095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C5O00_RS01095	COG0519	Catalyzes the synthesis of GMP from XMP
C5O00_RS01100	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C5O00_RS01150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5O00_RS01155	COG0552	protein localization to endoplasmic reticulum
C5O00_RS01165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5O00_RS01170	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5O00_RS01175	COG1058	Belongs to the CinA family
C5O00_RS01175	COG1546	Belongs to the CinA family
C5O00_RS01185	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5O00_RS01190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5O00_RS01200	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5O00_RS01210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C5O00_RS01220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5O00_RS01235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5O00_RS01240	COG1506	peptidase
C5O00_RS01245	COG0326	Molecular chaperone. Has ATPase activity
C5O00_RS01330	COG1482	cell wall glycoprotein biosynthetic process
C5O00_RS01340	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C5O00_RS01375	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C5O00_RS01400	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C5O00_RS01405	COG0085	RNA polymerase activity
C5O00_RS01410	COG0222	ribosome binding
C5O00_RS01415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C5O00_RS01420	COG0081	regulation of translation
C5O00_RS01425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C5O00_RS01435	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5O00_RS01445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C5O00_RS01475	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C5O00_RS01480	COG4974	Belongs to the 'phage' integrase family
C5O00_RS01485	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C5O00_RS01490	COG1629	transport
C5O00_RS01490	COG4206	TonB-dependent receptor
C5O00_RS01495	COG1960	acyl-CoA dehydrogenase activity
C5O00_RS01505	COG1115	amino acid carrier protein
C5O00_RS01510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5O00_RS01530	COG0577	efflux transmembrane transporter activity
C5O00_RS01535	COG3876	Protein conserved in bacteria
C5O00_RS01545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5O00_RS01560	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C5O00_RS01585	COG2884	Cell division ATP-binding protein ftsE
C5O00_RS01605	COG1216	Glycosyl transferase, family 2
C5O00_RS01605	COG0463	Glycosyl transferase, family 2
C5O00_RS01615	COG0438	transferase activity, transferring glycosyl groups
C5O00_RS01660	COG1217	gtp-binding protein TYPA
C5O00_RS01670	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C5O00_RS01680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C5O00_RS01680	COG0617	tRNA 3'-terminal CCA addition
C5O00_RS01680	COG0517	IMP dehydrogenase activity
C5O00_RS01700	COG4452	Inner membrane protein CreD
C5O00_RS01710	COG0784	Response regulator, receiver
C5O00_RS01710	COG2205	protein histidine kinase activity
C5O00_RS01750	COG1705	Flagellar rod assembly protein muramidase FlgJ
C5O00_RS01750	COG1388	LysM domain
C5O00_RS01770	COG1054	Belongs to the UPF0176 family
C5O00_RS01775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5O00_RS01785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5O00_RS01790	COG1846	Transcriptional regulator
C5O00_RS01795	COG2353	YceI-like domain
C5O00_RS01810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C5O00_RS01815	COG0512	Glutamine amidotransferase of anthranilate synthase
C5O00_RS01815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5O00_RS01820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5O00_RS01825	COG0134	indole-3-glycerol-phosphate synthase activity
C5O00_RS01830	COG0135	phosphoribosylanthranilate isomerase activity
C5O00_RS01835	COG0133	tryptophan synthase activity
C5O00_RS01840	COG0159	tryptophan synthase activity
C5O00_RS01860	COG3022	response to hydroperoxide
C5O00_RS01865	COG0564	pseudouridine synthase activity
C5O00_RS01875	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5O00_RS01880	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C5O00_RS01885	COG2135	peptidase activity
C5O00_RS01890	COG0268	Binds directly to 16S ribosomal RNA
C5O00_RS01900	COG0442	prolyl-tRNA aminoacylation
C5O00_RS01925	COG0302	gtp cyclohydrolase
C5O00_RS01930	COG0215	cysteine-tRNA ligase activity
C5O00_RS01935	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C5O00_RS01940	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C5O00_RS01950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5O00_RS01955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5O00_RS01960	COG0039	L-malate dehydrogenase activity
C5O00_RS01965	COG0187	DNA topoisomerase II activity
C5O00_RS01975	COG0602	queuosine metabolic process
C5O00_RS01980	COG0251	oxidation-reduction process
C5O00_RS01985	COG0433	COG0433 Predicted ATPase
C5O00_RS02025	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5O00_RS02030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C5O00_RS02065	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C5O00_RS02090	COG4935	Belongs to the peptidase S8 family
C5O00_RS02090	COG2234	aminopeptidase activity
C5O00_RS02145	COG3851	Histidine kinase
C5O00_RS02185	COG0018	arginyl-trna synthetase
C5O00_RS02195	COG0702	epimerase
C5O00_RS02205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5O00_RS02210	COG1477	protein flavinylation
C5O00_RS02230	COG0110	maltose O-acetyltransferase activity
C5O00_RS02250	COG0148	phosphopyruvate hydratase activity
C5O00_RS02255	COG0505	Belongs to the CarA family
C5O00_RS02260	COG0203	ribosomal protein L17
C5O00_RS02265	COG0202	RNA polymerase activity
C5O00_RS02270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C5O00_RS02275	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C5O00_RS02280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C5O00_RS02285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C5O00_RS02290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C5O00_RS02295	COG0201	protein transport
C5O00_RS02300	COG0200	Binds to the 23S rRNA
C5O00_RS02305	COG1841	ribosomal large subunit assembly
C5O00_RS02310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C5O00_RS02315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C5O00_RS02320	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C5O00_RS02325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C5O00_RS02330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C5O00_RS02335	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C5O00_RS02340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C5O00_RS02345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C5O00_RS02350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C5O00_RS02355	COG0255	Belongs to the universal ribosomal protein uL29 family
C5O00_RS02360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C5O00_RS02365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C5O00_RS02370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C5O00_RS02375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C5O00_RS02380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C5O00_RS02385	COG0089	rRNA binding
C5O00_RS02390	COG0088	Forms part of the polypeptide exit tunnel
C5O00_RS02395	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C5O00_RS02400	COG0051	transcription antitermination factor activity, RNA binding
C5O00_RS02405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5O00_RS02410	COG0049	tRNA binding
C5O00_RS02415	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C5O00_RS02425	COG1629	transport
C5O00_RS02450	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C5O00_RS02480	COG2003	Belongs to the UPF0758 family
C5O00_RS02490	COG2808	Putative FMN-binding domain
C5O00_RS02495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C5O00_RS02510	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C5O00_RS02515	COG0563	adenylate kinase activity
C5O00_RS02520	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C5O00_RS02525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C5O00_RS02530	COG0339	signal peptide processing
C5O00_RS02550	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5O00_RS02550	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5O00_RS02555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5O00_RS02570	COG1785	Belongs to the alkaline phosphatase family
C5O00_RS02575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5O00_RS02605	COG0300	oxidoreductase activity
C5O00_RS02615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C5O00_RS02620	COG0295	cytidine deaminase activity
C5O00_RS02635	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5O00_RS02640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5O00_RS02645	COG0668	transmembrane transport
C5O00_RS02695	COG0285	dihydrofolate synthase activity
C5O00_RS02710	COG0848	biopolymer transport protein
C5O00_RS02715	COG0811	peptide transport
C5O00_RS02730	COG1960	acyl-CoA dehydrogenase activity
C5O00_RS02790	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C5O00_RS02800	COG3292	Two component regulator propeller
C5O00_RS02800	COG0745	RESPONSE REGULATOR receiver
C5O00_RS02800	COG2205	protein histidine kinase activity
C5O00_RS02810	COG2885	chlorophyll binding
C5O00_RS02825	COG0321	lipoyl(octanoyl) transferase activity
C5O00_RS02835	COG3119	arylsulfatase activity
C5O00_RS02840	COG0401	homolog of Blt101
C5O00_RS02850	COG2197	response regulator
C5O00_RS02860	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5O00_RS02865	COG1846	Transcriptional regulator
C5O00_RS02870	COG0793	Belongs to the peptidase S41A family
C5O00_RS02880	COG4682	membrane
C5O00_RS02910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C5O00_RS02915	COG0791	NLP P60 protein
C5O00_RS02915	COG1388	LysM domain
C5O00_RS02960	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C5O00_RS02975	COG0022	dehydrogenase e1 component
C5O00_RS02980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5O00_RS02985	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5O00_RS03000	COG1012	belongs to the aldehyde dehydrogenase family
C5O00_RS03000	COG2030	dehydratase
C5O00_RS03010	COG0183	Belongs to the thiolase family
C5O00_RS03020	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5O00_RS03025	COG1024	Enoyl-CoA hydratase
C5O00_RS03030	COG2151	metal-sulfur cluster biosynthetic enzyme
C5O00_RS03035	COG3396	Phenylacetate-CoA oxygenase
C5O00_RS03040	COG3460	Phenylacetate-CoA oxygenase
C5O00_RS03045	COG3396	Phenylacetate-CoA oxygenase
C5O00_RS03050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5O00_RS03055	COG1309	transcriptional regulator
C5O00_RS03100	COG1428	Deoxynucleoside kinase
C5O00_RS03105	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C5O00_RS03120	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5O00_RS03120	COG0022	dehydrogenase e1 component
C5O00_RS03135	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5O00_RS03145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C5O00_RS03150	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C5O00_RS03165	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5O00_RS03185	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5O00_RS03195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C5O00_RS03200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C5O00_RS03270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C5O00_RS03280	COG1428	Deoxynucleoside kinase
C5O00_RS03315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C5O00_RS03325	COG0544	peptidyl-prolyl cis-trans isomerase activity
C5O00_RS03330	COG1950	PFAM Membrane protein of
C5O00_RS03335	COG0596	Alpha beta hydrolase
C5O00_RS03340	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C5O00_RS03350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5O00_RS03360	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5O00_RS03380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C5O00_RS03385	COG4565	transcriptional regulatory protein
C5O00_RS03390	COG3275	phosphorelay sensor kinase activity
C5O00_RS03420	COG1331	Highly conserved protein containing a thioredoxin domain
C5O00_RS03450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5O00_RS03460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5O00_RS03465	COG0577	efflux transmembrane transporter activity
C5O00_RS03465	COG1136	(ABC) transporter
C5O00_RS03470	COG0577	efflux transmembrane transporter activity
C5O00_RS03470	COG1136	(ABC) transporter
C5O00_RS03475	COG1136	(ABC) transporter
C5O00_RS03485	COG2322	membrane
C5O00_RS03490	COG1999	signal sequence binding
C5O00_RS03510	COG1845	cytochrome c oxidase, subunit III
C5O00_RS03515	COG0109	protoheme IX farnesyltransferase activity
C5O00_RS03520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5O00_RS03550	COG0509	glycine decarboxylation via glycine cleavage system
C5O00_RS03560	COG0632	four-way junction helicase activity
C5O00_RS03570	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C5O00_RS03580	COG2255	four-way junction helicase activity
C5O00_RS03585	COG0534	Mate efflux family protein
C5O00_RS03590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5O00_RS03595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C5O00_RS03615	COG3743	rRNA binding
C5O00_RS03615	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C5O00_RS03620	COG0437	4 iron, 4 sulfur cluster binding
C5O00_RS03640	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C5O00_RS03645	COG2251	uridine kinase activity
C5O00_RS03645	COG0195	Participates in both transcription termination and antitermination
C5O00_RS03650	COG0779	Required for maturation of 30S ribosomal subunits
C5O00_RS03655	COG0589	response to stress
C5O00_RS03665	COG4585	Histidine kinase
C5O00_RS03710	COG3118	belongs to the thioredoxin family
C5O00_RS03715	COG1408	metallophosphoesterase
C5O00_RS03720	COG3537	Alpha-1,2-mannosidase
C5O00_RS03725	COG1446	asparaginase
C5O00_RS03730	COG3920	Histidine kinase
C5O00_RS03750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5O00_RS03750	COG0189	ligase activity
C5O00_RS03755	COG4242	Belongs to the peptidase S51 family
C5O00_RS03760	COG1446	asparaginase
C5O00_RS03765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5O00_RS03765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5O00_RS03780	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C5O00_RS03785	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C5O00_RS03790	COG0052	Belongs to the universal ribosomal protein uS2 family
C5O00_RS03795	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C5O00_RS03805	COG0528	UMP kinase activity
C5O00_RS03810	COG0233	cytoplasmic translational termination
C5O00_RS03825	COG0017	Asparaginyl-tRNA synthetase
C5O00_RS03830	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C5O00_RS03860	COG0811	peptide transport
C5O00_RS03870	COG0252	asparaginase activity
C5O00_RS03875	COG0084	hydrolase, TatD family'
C5O00_RS03895	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5O00_RS03940	COG4206	TonB-dependent receptor
C5O00_RS03940	COG1629	transport
C5O00_RS03945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C5O00_RS03960	COG1278	Cold shock
C5O00_RS03970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C5O00_RS03975	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C5O00_RS03985	COG1629	transport
C5O00_RS04005	COG1283	sodium-dependent phosphate transmembrane transporter activity
C5O00_RS04020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5O00_RS04020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C5O00_RS04040	COG2095	MarC family integral membrane protein
C5O00_RS04050	COG0793	Belongs to the peptidase S41A family
C5O00_RS04065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5O00_RS04065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5O00_RS04075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5O00_RS04080	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C5O00_RS04085	COG0193	aminoacyl-tRNA hydrolase activity
C5O00_RS04090	COG0196	riboflavin kinase activity
C5O00_RS04100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C5O00_RS04120	COG2885	chlorophyll binding
C5O00_RS04125	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C5O00_RS04130	COG2239	Acts as a magnesium transporter
C5O00_RS04145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5O00_RS04150	COG2197	response regulator
C5O00_RS04190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5O00_RS04205	COG1696	Membrane protein involved in D-alanine export
C5O00_RS04255	COG0460	homoserine dehydrogenase
C5O00_RS04255	COG0527	aspartate kinase activity
C5O00_RS04265	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C5O00_RS04280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5O00_RS04285	COG0784	Response regulator, receiver
C5O00_RS04285	COG2205	protein histidine kinase activity
C5O00_RS04295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5O00_RS04310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C5O00_RS04315	COG0792	nuclease activity
C5O00_RS04320	COG1619	proteins homologs of microcin C7 resistance protein MccF
C5O00_RS04335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5O00_RS04335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5O00_RS04340	COG0427	acetyl-CoA hydrolase
C5O00_RS04435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5O00_RS04450	COG0629	single-stranded DNA binding
C5O00_RS04470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5O00_RS04475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5O00_RS04480	COG0439	Biotin carboxylase
C5O00_RS04490	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C5O00_RS04510	COG1381	Involved in DNA repair and RecF pathway recombination
C5O00_RS04530	COG0626	cystathionine gamma-synthase activity
C5O00_RS04545	COG0697	spore germination
C5O00_RS04560	COG1309	transcriptional regulator
C5O00_RS04570	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C5O00_RS04595	COG2211	Major facilitator Superfamily
C5O00_RS04620	COG1561	YicC-like family, N-terminal region
C5O00_RS04625	COG0194	GDP metabolic process
C5O00_RS04630	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C5O00_RS04640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C5O00_RS04655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C5O00_RS04670	COG0659	secondary active sulfate transmembrane transporter activity
C5O00_RS04690	COG2304	oxidoreductase activity
C5O00_RS04695	COG2304	oxidoreductase activity
C5O00_RS04710	COG0714	Associated with various cellular activities
C5O00_RS04715	COG4989	oxidoreductase activity
C5O00_RS04730	COG4221	oxidoreductase activity
C5O00_RS04750	COG4260	virion core protein, lumpy skin disease virus
C5O00_RS04770	COG1012	belongs to the aldehyde dehydrogenase family
C5O00_RS04775	COG0259	pyridoxamine-phosphate oxidase activity
C5O00_RS04790	COG1446	asparaginase
C5O00_RS04795	COG2329	Antibiotic biosynthesis monooxygenase
C5O00_RS04805	COG4953	penicillin-binding protein 1C
C5O00_RS04810	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5O00_RS04825	COG2954	triphosphatase activity
C5O00_RS04830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5O00_RS04840	COG0469	pyruvate kinase activity
C5O00_RS04850	COG0571	ribonuclease III activity
C5O00_RS04855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5O00_RS04860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5O00_RS04870	COG0328	RNA-DNA hybrid ribonuclease activity
C5O00_RS04870	COG3341	Caulimovirus viroplasmin
C5O00_RS04890	COG1063	alcohol dehydrogenase
C5O00_RS04900	COG1074	ATP-dependent DNA helicase activity
C5O00_RS04910	COG3047	cAMP biosynthetic process
C5O00_RS04910	COG2885	chlorophyll binding
C5O00_RS04945	COG0534	Mate efflux family protein
C5O00_RS04950	COG0720	synthase
C5O00_RS04955	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5O00_RS04965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C5O00_RS04965	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C5O00_RS04975	COG1573	uracil-dna glycosylase
C5O00_RS04980	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C5O00_RS04990	COG1435	thymidine kinase activity
C5O00_RS05000	COG1970	mechanosensitive ion channel activity
C5O00_RS05005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C5O00_RS05015	COG1505	serine-type exopeptidase activity
C5O00_RS05020	COG3842	ATPase activity
C5O00_RS05035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5O00_RS05045	COG0439	Biotin carboxylase
C5O00_RS05050	COG0511	ligase activity, forming carbon-carbon bonds
C5O00_RS05055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5O00_RS05060	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C5O00_RS05070	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C5O00_RS05090	COG0346	lactoylglutathione lyase activity
C5O00_RS05095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C5O00_RS05105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5O00_RS05110	COG0481	GTPase activity
C5O00_RS05115	COG3275	phosphorelay sensor kinase activity
C5O00_RS05135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5O00_RS05150	COG0594	ribonuclease P activity
C5O00_RS05155	COG3409	Peptidoglycan-binding domain 1 protein
C5O00_RS05155	COG0793	Belongs to the peptidase S41A family
C5O00_RS05170	COG0004	ammonium transporteR
C5O00_RS05175	COG2153	protein acetylation
C5O00_RS05185	COG0698	ribose 5-phosphate isomerase
C5O00_RS05195	COG0557	exoribonuclease II activity
C5O00_RS05210	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C5O00_RS05215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5O00_RS05240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5O00_RS05250	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C5O00_RS05255	COG0445	tRNA wobble uridine modification
C5O00_RS05270	COG0126	phosphoglycerate kinase activity
C5O00_RS05275	COG1388	LysM domain
C5O00_RS05275	COG1705	Flagellar rod assembly protein muramidase FlgJ
C5O00_RS05285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5O00_RS05345	COG0438	transferase activity, transferring glycosyl groups
C5O00_RS05370	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C5O00_RS05375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5O00_RS05385	COG1215	transferase activity, transferring glycosyl groups
C5O00_RS05420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5O00_RS05445	COG0356	it plays a direct role in the translocation of protons across the membrane
C5O00_RS05450	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C5O00_RS05455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C5O00_RS05460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C5O00_RS05465	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C5O00_RS05470	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C5O00_RS05485	COG0756	dUTP diphosphatase activity
C5O00_RS05490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C5O00_RS05525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5O00_RS05525	COG0758	DNA mediated transformation
C5O00_RS05550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C5O00_RS05555	COG1054	Belongs to the UPF0176 family
C5O00_RS05560	COG1774	PSP1 C-terminal conserved region
C5O00_RS05570	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C5O00_RS05575	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C5O00_RS05580	COG2197	response regulator
C5O00_RS05590	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C5O00_RS05595	COG4172	Belongs to the ABC transporter superfamily
C5O00_RS05610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5O00_RS05615	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5O00_RS05625	COG1253	flavin adenine dinucleotide binding
C5O00_RS05630	COG0113	porphobilinogen synthase activity
C5O00_RS05635	COG0408	coproporphyrinogen oxidase activity
C5O00_RS05640	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C5O00_RS05650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C5O00_RS05660	COG0181	hydroxymethylbilane synthase activity
C5O00_RS05665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C5O00_RS05675	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C5O00_RS05680	COG0534	Mate efflux family protein
C5O00_RS05685	COG2326	polyphosphate kinase activity
C5O00_RS05700	COG1981	membrane
C5O00_RS05710	COG1024	Enoyl-CoA hydratase
C5O00_RS05755	COG0803	Belongs to the bacterial solute-binding protein 9 family
C5O00_RS05760	COG1121	(ABC) transporter
C5O00_RS05765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5O00_RS05770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5O00_RS05790	COG1999	signal sequence binding
C5O00_RS05795	COG0750	zinc metalloprotease
C5O00_RS05805	COG2827	Endonuclease containing a URI domain
C5O00_RS05810	COG4753	response regulator
C5O00_RS05810	COG2207	Transcriptional regulator
C5O00_RS05830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5O00_RS05860	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C5O00_RS05865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5O00_RS05880	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C5O00_RS05885	COG0673	inositol 2-dehydrogenase activity
C5O00_RS05900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5O00_RS05910	COG3590	peptidase
C5O00_RS05915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5O00_RS05940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C5O00_RS05955	COG0784	Response regulator, receiver
C5O00_RS05955	COG2205	protein histidine kinase activity
C5O00_RS05970	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C5O00_RS05980	COG0189	ligase activity
C5O00_RS05985	COG0322	excinuclease ABC activity
C5O00_RS05995	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C5O00_RS06000	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C5O00_RS06020	COG4771	TonB-dependent receptor
C5O00_RS06075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5O00_RS06090	COG3425	synthase
C5O00_RS06095	COG2151	metal-sulfur cluster biosynthetic enzyme
C5O00_RS06100	COG2166	iron-sulfur cluster assembly
C5O00_RS06110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5O00_RS06115	COG0719	Fe-S assembly protein
C5O00_RS06120	COG0396	ATPase activity
C5O00_RS06130	COG0719	Fe-S assembly protein
C5O00_RS06180	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C5O00_RS06195	COG1114	Component of the transport system for branched-chain amino acids
C5O00_RS06205	COG0006	proline dipeptidase activity
C5O00_RS06225	COG1053	succinate dehydrogenase
C5O00_RS06240	COG0436	Aminotransferase
C5O00_RS06260	COG1040	competence protein
C5O00_RS06270	COG0423	glycine-tRNA ligase activity
C5O00_RS06300	COG0708	Exodeoxyribonuclease III
C5O00_RS06305	COG1360	Flagellar Motor Protein
C5O00_RS06310	COG0667	Aldo Keto reductase
C5O00_RS06320	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C5O00_RS06325	COG4585	Histidine kinase
C5O00_RS06375	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C5O00_RS06380	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C5O00_RS06385	COG0297	glycogen (starch) synthase activity
C5O00_RS06395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5O00_RS06425	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C5O00_RS06435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C5O00_RS06440	COG0156	8-amino-7-oxononanoate synthase activity
C5O00_RS06445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C5O00_RS06450	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5O00_RS06460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C5O00_RS06485	COG1530	ribonuclease E activity
C5O00_RS06500	COG0629	single-stranded DNA binding
C5O00_RS06525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C5O00_RS06530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C5O00_RS06545	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C5O00_RS06555	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C5O00_RS06575	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C5O00_RS06590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5O00_RS06610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5O00_RS06620	COG2031	fatty acid transporter
C5O00_RS06625	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C5O00_RS06635	COG2957	Belongs to the agmatine deiminase family
C5O00_RS06645	COG0519	Catalyzes the synthesis of GMP from XMP
C5O00_RS06660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C5O00_RS06665	COG1968	undecaprenyl-diphosphatase activity
C5O00_RS06680	COG2177	Part of the ABC transporter FtsEX involved in
C5O00_RS06690	COG0495	leucyl-tRNA aminoacylation
C5O00_RS06705	COG2363	Small membrane protein
C5O00_RS06710	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C5O00_RS06725	COG0463	Glycosyl transferase, family 2
C5O00_RS06730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5O00_RS06745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C5O00_RS06765	COG0745	RESPONSE REGULATOR receiver
C5O00_RS06770	COG5002	protein histidine kinase activity
C5O00_RS06775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5O00_RS06780	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C5O00_RS06795	COG0489	protein tyrosine kinase activity
C5O00_RS06805	COG0492	ferredoxin-NADP+ reductase activity
C5O00_RS06810	COG0633	Ferredoxin
C5O00_RS06825	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C5O00_RS06830	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C5O00_RS06835	COG0228	four-way junction DNA binding
C5O00_RS06855	COG0740	serine-type endopeptidase activity
C5O00_RS06905	COG2205	protein histidine kinase activity
C5O00_RS06905	COG0784	Response regulator, receiver
C5O00_RS06940	COG4585	Histidine kinase
C5O00_RS06945	COG2197	response regulator
C5O00_RS06965	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C5O00_RS06975	COG0732	type I restriction modification DNA specificity domain
C5O00_RS06980	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C5O00_RS06990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C5O00_RS06995	COG1704	LemA family
C5O00_RS07025	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C5O00_RS07030	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C5O00_RS07035	COG3383	formate dehydrogenase (NAD+) activity
C5O00_RS07040	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C5O00_RS07050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C5O00_RS07055	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5O00_RS07055	COG0315	cyclic pyranopterin monophosphate synthase activity
C5O00_RS07065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C5O00_RS07075	COG0746	molybdenum cofactor guanylyltransferase activity
C5O00_RS07120	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C5O00_RS07150	COG1215	transferase activity, transferring glycosyl groups
C5O00_RS07160	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C5O00_RS07170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5O00_RS07250	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C5O00_RS07295	COG2824	Alkylphosphonate utilization operon protein PhnA
C5O00_RS07325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5O00_RS07335	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C5O00_RS07355	COG2814	Major facilitator Superfamily
C5O00_RS07365	COG2081	HI0933 family
C5O00_RS07425	COG1187	pseudouridine synthase activity
C5O00_RS07435	COG0010	Belongs to the arginase family
C5O00_RS07470	COG2234	aminopeptidase activity
C5O00_RS07485	COG1215	transferase activity, transferring glycosyl groups
C5O00_RS07490	COG1216	Glycosyl transferase, family 2
C5O00_RS07515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5O00_RS07540	COG0306	phosphate transporter
C5O00_RS07545	COG2226	methyltransferase
C5O00_RS07550	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C5O00_RS07580	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5O00_RS07585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5O00_RS07610	COG1082	Xylose isomerase domain protein TIM barrel
C5O00_RS07645	COG4206	TonB-dependent receptor
C5O00_RS07645	COG1629	transport
C5O00_RS07655	COG1609	Transcriptional regulator
C5O00_RS07660	COG1621	beta-fructofuranosidase activity
C5O00_RS07675	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C5O00_RS07725	COG3104	oligopeptide transport
C5O00_RS07730	COG3104	oligopeptide transport
C5O00_RS07740	COG0658	competence protein
C5O00_RS07740	COG2333	competence protein COMEC
C5O00_RS07745	COG0791	NLP P60 protein
C5O00_RS07750	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5O00_RS07760	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C5O00_RS07765	COG0793	Belongs to the peptidase S41A family
C5O00_RS07770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5O00_RS07780	COG0772	Belongs to the SEDS family
C5O00_RS07800	COG1077	Cell shape determining protein MreB Mrl
C5O00_RS07805	COG0138	bifunctional purine biosynthesis protein purh
C5O00_RS07855	COG4206	TonB-dependent receptor
C5O00_RS07855	COG1629	transport
C5O00_RS07865	COG0459	protein refolding
C5O00_RS07870	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C5O00_RS07895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5O00_RS07915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5O00_RS07935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5O00_RS07935	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C5O00_RS07945	COG0488	(ABC) transporter
C5O00_RS07965	COG0861	Integral membrane protein TerC family
C5O00_RS08040	COG3263	regulation of cellular component size
C5O00_RS08045	COG0798	PFAM Bile acid sodium symporter
C5O00_RS08155	COG1054	Belongs to the UPF0176 family
C5O00_RS08160	COG0450	alkyl hydroperoxide reductase
C5O00_RS08165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5O00_RS08165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5O00_RS08170	COG0730	response to heat
C5O00_RS08180	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C5O00_RS08190	COG1160	GTP binding
C5O00_RS08230	COG1704	LemA family
C5O00_RS08240	COG0739	heme binding
C5O00_RS08245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5O00_RS08285	COG2197	response regulator
C5O00_RS08290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C5O00_RS08300	COG0460	homoserine dehydrogenase
C5O00_RS08300	COG0527	aspartate kinase activity
C5O00_RS08305	COG0083	homoserine kinase activity
C5O00_RS08310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C5O00_RS08315	COG0626	cystathionine gamma-synthase activity
C5O00_RS08320	COG0527	aspartate kinase activity
C5O00_RS08320	COG0460	homoserine dehydrogenase
C5O00_RS08325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5O00_RS08330	COG1765	OsmC-like protein
C5O00_RS08350	COG1959	2 iron, 2 sulfur cluster binding
C5O00_RS08360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5O00_RS08390	COG0077	Prephenate dehydratase
C5O00_RS08395	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C5O00_RS08405	COG1162	GTPase activity
C5O00_RS08410	COG1490	D-aminoacyl-tRNA deacylase activity
C5O00_RS08430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C5O00_RS08440	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C5O00_RS08465	COG0358	DNA primase activity
C5O00_RS08470	COG2197	response regulator
C5O00_RS08475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C5O00_RS08495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C5O00_RS08505	COG2001	Belongs to the MraZ family
C5O00_RS08510	COG0275	rRNA processing
C5O00_RS08520	COG0768	penicillin binding
C5O00_RS08525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5O00_RS08530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5O00_RS08535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5O00_RS08540	COG0772	Belongs to the SEDS family
C5O00_RS08545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5O00_RS08550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C5O00_RS08565	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C5O00_RS08570	COG1610	YqeY-like protein
C5O00_RS08605	COG2217	Heavy metal translocating P-type atpase
C5O00_RS08615	COG3278	Belongs to the heme-copper respiratory oxidase family
C5O00_RS08625	COG2010	Cytochrome c
C5O00_RS08630	COG0348	domain, Protein
C5O00_RS08645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5O00_RS08655	COG3228	Belongs to the MtfA family
C5O00_RS08660	COG0492	ferredoxin-NADP+ reductase activity
C5O00_RS08675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5O00_RS08685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5O00_RS08690	COG0784	Response regulator, receiver
C5O00_RS08690	COG2205	protein histidine kinase activity
C5O00_RS08695	COG1185	polyribonucleotide nucleotidyltransferase activity
C5O00_RS08700	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C5O00_RS08715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C5O00_RS08730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5O00_RS08740	COG2226	methyltransferase
C5O00_RS08755	COG0436	Aminotransferase
C5O00_RS08760	COG3239	Fatty acid desaturase
C5O00_RS08765	COG0357	Ribosomal RNA small subunit methyltransferase G
C5O00_RS08770	COG1012	belongs to the aldehyde dehydrogenase family
C5O00_RS08800	COG1805	sodium ion transport
C5O00_RS08805	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C5O00_RS08815	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C5O00_RS08825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5O00_RS08850	COG2226	methyltransferase
C5O00_RS08865	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C5O00_RS08870	COG0501	Belongs to the peptidase M48B family
C5O00_RS08875	COG1876	peptidase activity
C5O00_RS08880	COG3340	Belongs to the peptidase S51 family
C5O00_RS08900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5O00_RS08905	COG0671	phosphoesterase, PA-phosphatase related
C5O00_RS08920	COG4585	Histidine kinase
C5O00_RS08925	COG2197	response regulator
C5O00_RS08940	COG1028	Short-chain dehydrogenase reductase Sdr
C5O00_RS08955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5O00_RS08960	COG3844	kynureninase activity
C5O00_RS08985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5O00_RS08995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5O00_RS09005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C5O00_RS09010	COG1663	tetraacyldisaccharide 4'-kinase activity
C5O00_RS09020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5O00_RS09025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C5O00_RS09040	COG1215	transferase activity, transferring glycosyl groups
C5O00_RS09055	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C5O00_RS09060	COG0436	Aminotransferase
C5O00_RS09065	COG0750	zinc metalloprotease
C5O00_RS09075	COG0525	valine-tRNA ligase activity
C5O00_RS09085	COG0688	phosphatidylethanolamine metabolic process
C5O00_RS09090	COG4589	Belongs to the CDS family
C5O00_RS09100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5O00_RS09105	COG0799	negative regulation of ribosome biogenesis
C5O00_RS09120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C5O00_RS09160	COG0101	tRNA pseudouridine synthase activity
C5O00_RS09165	COG1132	(ABC) transporter
C5O00_RS09175	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C5O00_RS09180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C5O00_RS09195	COG0601	transmembrane transport
C5O00_RS09200	COG0149	triose-phosphate isomerase activity
C5O00_RS09205	COG2264	protein methyltransferase activity
C5O00_RS09220	COG2827	Endonuclease containing a URI domain
C5O00_RS09225	COG2827	Endonuclease containing a URI domain
C5O00_RS09230	COG2827	Endonuclease containing a URI domain
C5O00_RS09235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5O00_RS09295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C5O00_RS09300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C5O00_RS09305	COG0284	orotidine-5'-phosphate decarboxylase activity
C5O00_RS09325	COG1703	isobutyryl-CoA mutase activity
C5O00_RS09325	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5O00_RS09325	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5O00_RS09335	COG1522	sequence-specific DNA binding
C5O00_RS09355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5O00_RS09385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5O00_RS09395	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C5O00_RS09395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5O00_RS09400	COG1090	epimerase
C5O00_RS09410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5O00_RS09415	COG0484	heat shock protein binding
C5O00_RS09420	COG4152	abc transporter atp-binding protein
C5O00_RS09425	COG1668	transmembrane transport
C5O00_RS09430	COG3264	Mechanosensitive ion channel
C5O00_RS09430	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C5O00_RS09440	COG2204	response regulator
C5O00_RS09445	COG2326	polyphosphate kinase activity
C5O00_RS09470	COG0671	phosphoesterase, PA-phosphatase related
C5O00_RS09490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5O00_RS09535	COG1595	DNA-templated transcription, initiation
C5O00_RS09555	COG0653	protein targeting
C5O00_RS09580	COG1136	(ABC) transporter
C5O00_RS09590	COG0488	(ABC) transporter
C5O00_RS09610	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C5O00_RS09625	COG1696	Membrane protein involved in D-alanine export
C5O00_RS09645	COG3551	Protein conserved in bacteria
C5O00_RS09655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5O00_RS09660	COG4106	trans-aconitate 2-methyltransferase activity
C5O00_RS09680	COG1215	transferase activity, transferring glycosyl groups
C5O00_RS09685	COG3551	Protein conserved in bacteria
C5O00_RS09690	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C5O00_RS09695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5O00_RS09715	COG1216	Glycosyl transferase, family 2
C5O00_RS09715	COG0463	Glycosyl transferase, family 2
C5O00_RS09720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5O00_RS09750	COG1083	cytidylyl-transferase
C5O00_RS09755	COG2089	acid synthase
C5O00_RS09805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5O00_RS09820	COG1183	phosphatidylcholine synthase activity
C5O00_RS09825	COG1137	ATPase activity
C5O00_RS09835	COG0805	protein transport
C5O00_RS09840	COG0517	IMP dehydrogenase activity
C5O00_RS09840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C5O00_RS09845	COG0514	ATP-dependent DNA helicase (RecQ)
C5O00_RS09850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C5O00_RS09855	COG2318	DinB family
C5O00_RS09870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5O00_RS09880	COG3852	Histidine kinase
C5O00_RS09890	COG0659	secondary active sulfate transmembrane transporter activity
C5O00_RS09905	COG1132	(ABC) transporter
C5O00_RS09915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5O00_RS09925	COG1862	Preprotein translocase
C5O00_RS09930	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5O00_RS09935	COG0167	dihydroorotate dehydrogenase activity
C5O00_RS09945	COG1280	lysine exporter protein (LysE YggA)
C5O00_RS09955	COG0737	Belongs to the 5'-nucleotidase family
C5O00_RS09965	COG1730	sister chromatid segregation
C5O00_RS09985	COG0516	GMP reductase activity
C5O00_RS09985	COG0517	IMP dehydrogenase activity
C5O00_RS10005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5O00_RS10015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5O00_RS10020	COG0714	Associated with various cellular activities
C5O00_RS10025	COG2755	lipolytic protein G-D-S-L family
C5O00_RS10025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C5O00_RS10040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5O00_RS10060	COG1233	COG1233 Phytoene dehydrogenase and related
C5O00_RS10080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C5O00_RS10085	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C5O00_RS10090	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C5O00_RS10100	COG3958	Transketolase
C5O00_RS10110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5O00_RS10115	COG0343	queuine tRNA-ribosyltransferase activity
C5O00_RS10130	COG0825	malonyl-CoA metabolic process
C5O00_RS10135	COG0305	Participates in initiation and elongation during chromosome replication
C5O00_RS10150	COG2885	chlorophyll binding
C5O00_RS10155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C5O00_RS10160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C5O00_RS10165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C5O00_RS10170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5O00_RS10225	COG2972	Histidine kinase
C5O00_RS10235	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C5O00_RS10240	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C5O00_RS10250	COG1929	Belongs to the glycerate kinase type-1 family
C5O00_RS10270	COG0335	large ribosomal subunit rRNA binding
C5O00_RS10275	COG0336	Belongs to the RNA methyltransferase TrmD family
C5O00_RS10285	COG0456	acetyltransferase
C5O00_RS10290	COG0673	inositol 2-dehydrogenase activity
C5O00_RS10300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5O00_RS10305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C5O00_RS10315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C5O00_RS10335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5O00_RS10340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C5O00_RS10350	COG1739	Uncharacterized protein family UPF0029
C5O00_RS10360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5O00_RS10360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5O00_RS10365	COG0456	acetyltransferase
C5O00_RS10370	COG2890	protein-(glutamine-N5) methyltransferase activity
C5O00_RS10380	COG4733	cellulase activity
C5O00_RS10380	COG5297	Belongs to the glycosyl hydrolase family 6
C5O00_RS10385	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5O00_RS10395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5O00_RS10420	COG0497	DNA recombination
C5O00_RS10425	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C5O00_RS10440	COG1216	Glycosyl transferase, family 2
C5O00_RS10440	COG0463	Glycosyl transferase, family 2
C5O00_RS10450	COG0237	dephospho-CoA kinase activity
C5O00_RS10465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C5O00_RS10470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5O00_RS10480	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C5O00_RS10490	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5O00_RS10495	COG0673	inositol 2-dehydrogenase activity
C5O00_RS10500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C5O00_RS10520	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
C5O00_RS10530	COG3279	Response regulator of the LytR AlgR family
C5O00_RS10545	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C5O00_RS10550	COG4771	TonB-dependent receptor
C5O00_RS10555	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C5O00_RS10575	COG0542	response to heat
C5O00_RS10595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5O00_RS10610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5O00_RS10620	COG2197	response regulator
C5O00_RS10640	COG4206	TonB-dependent receptor
C5O00_RS10640	COG1629	transport
C5O00_RS10655	COG0300	oxidoreductase activity
C5O00_RS10660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C5O00_RS10670	COG0488	(ABC) transporter
C5O00_RS10710	COG1278	Cold shock
C5O00_RS10720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C5O00_RS10725	COG0308	aminopeptidase N
C5O00_RS10745	COG0745	RESPONSE REGULATOR receiver
C5O00_RS10745	COG2972	Histidine kinase
C5O00_RS10750	COG3279	Response regulator of the LytR AlgR family
C5O00_RS10755	COG0069	glutamate synthase activity
C5O00_RS10760	COG1473	amidohydrolase
C5O00_RS10770	COG0009	L-threonylcarbamoyladenylate synthase
C5O00_RS10810	COG1575	Belongs to the MenA family. Type 1 subfamily
C5O00_RS10815	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C5O00_RS10820	COG4948	Mandelate Racemase Muconate Lactonizing
C5O00_RS10835	COG1629	transport
C5O00_RS10850	COG0346	lactoylglutathione lyase activity
C5O00_RS10860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5O00_RS10870	COG0488	(ABC) transporter
C5O00_RS10880	COG0823	Involved in the tonB-independent uptake of proteins
C5O00_RS10880	COG4946	Tricorn protease homolog
C5O00_RS10880	COG1506	peptidase
C5O00_RS10895	COG0010	Belongs to the arginase family
C5O00_RS10900	COG1228	amidohydrolase
C5O00_RS10905	COG0626	cystathionine gamma-synthase activity
C5O00_RS10910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C5O00_RS10940	COG2234	aminopeptidase activity
C5O00_RS10960	COG0659	secondary active sulfate transmembrane transporter activity
C5O00_RS10975	COG1333	cytochrome c biogenesis protein
C5O00_RS10975	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C5O00_RS11000	COG0492	ferredoxin-NADP+ reductase activity
C5O00_RS11015	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5O00_RS11030	COG2217	Heavy metal translocating P-type atpase
C5O00_RS11040	COG2217	Heavy metal translocating P-type atpase
C5O00_RS11065	COG2217	Heavy metal translocating P-type atpase
C5O00_RS11085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5O00_RS11090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5O00_RS11090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5O00_RS11105	COG1674	ftsk spoiiie
C5O00_RS11125	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C5O00_RS11130	COG1757	Na H antiporter
C5O00_RS11150	COG0626	cystathionine gamma-synthase activity
C5O00_RS11155	COG1522	sequence-specific DNA binding
C5O00_RS11160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5O00_RS11180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C5O00_RS11185	COG0037	tRNA processing
C5O00_RS11205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5O00_RS11210	COG1554	hydrolase, family 65, central catalytic
C5O00_RS11215	COG0366	Alpha amylase catalytic
C5O00_RS11225	COG0205	6-phosphofructokinase activity
C5O00_RS11240	COG0166	Belongs to the GPI family
C5O00_RS11265	COG0606	chelatase, subunit chli
C5O00_RS11280	COG0612	Peptidase, M16
C5O00_RS11285	COG1914	H( )-stimulated, divalent metal cation uptake system
C5O00_RS11290	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C5O00_RS11295	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C5O00_RS11300	COG1984	allophanate hydrolase subunit 2
C5O00_RS11330	COG0564	pseudouridine synthase activity
C5O00_RS11335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C5O00_RS11345	COG1760	l-serine dehydratase
C5O00_RS11350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5O00_RS11355	COG2827	Endonuclease containing a URI domain
C5O00_RS11375	COG0443	Heat shock 70 kDa protein
C5O00_RS11405	COG2815	serine threonine protein kinase
C5O00_RS11405	COG0515	serine threonine protein kinase
C5O00_RS11450	COG1940	carbohydrate kinase activity
C5O00_RS11465	COG0584	glycerophosphoryl diester phosphodiesterase
C5O00_RS11505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C5O00_RS11515	COG0366	Alpha amylase catalytic
C5O00_RS11535	COG2050	protein possibly involved in aromatic compounds catabolism
C5O00_RS11540	COG1169	isochorismate synthase
C5O00_RS11545	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C5O00_RS11560	COG2996	Protein conserved in bacteria
C5O00_RS11600	COG0367	asparagine synthase
C5O00_RS11620	COG1611	Belongs to the LOG family
C5O00_RS11625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5O00_RS11635	COG0405	Gamma-glutamyltransferase
C5O00_RS11645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5O00_RS11665	COG2968	Membrane
C5O00_RS11670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5O00_RS11695	COG0783	Belongs to the Dps family
C5O00_RS11710	COG0529	Catalyzes the synthesis of activated sulfate
C5O00_RS11715	COG0175	sulfate reduction
C5O00_RS11735	COG2843	Capsule synthesis protein
C5O00_RS11750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5O00_RS11755	COG1045	serine acetyltransferase
C5O00_RS11760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5O00_RS11805	COG3047	cAMP biosynthetic process
C5O00_RS11805	COG2885	chlorophyll binding
C5O00_RS11810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5O00_RS11825	COG0592	DNA-directed DNA polymerase activity
C5O00_RS11850	COG1702	phosphate starvation-inducible protein PhoH
C5O00_RS11855	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C5O00_RS11870	COG1115	amino acid carrier protein
C5O00_RS11885	COG1363	Peptidase, m42
C5O00_RS11920	COG1272	protein, Hemolysin III
C5O00_RS11930	COG0116	Belongs to the methyltransferase superfamily
C5O00_RS11930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C5O00_RS11945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5O00_RS11950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5O00_RS11980	COG1104	cysteine desulfurase activity
C5O00_RS12010	COG1418	mRNA catabolic process
C5O00_RS12045	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C5O00_RS12050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5O00_RS12060	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5O00_RS12065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5O00_RS12080	COG2270	Major facilitator Superfamily
C5O00_RS12105	COG1595	DNA-templated transcription, initiation
C5O00_RS12110	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C5O00_RS12120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C5O00_RS12140	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C5O00_RS12145	COG0540	Belongs to the ATCase OTCase family
C5O00_RS12160	COG0259	pyridoxamine-phosphate oxidase activity
C5O00_RS12170	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C5O00_RS12185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C5O00_RS12210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5O00_RS12215	COG1454	alcohol dehydrogenase
C5O00_RS12225	COG0217	transcriptional regulatory protein
C5O00_RS12240	COG2154	pterin-4-alpha-carbinolamine dehydratase
C5O00_RS12250	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5O00_RS12255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C5O00_RS12255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C5O00_RS12260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5O00_RS12265	COG2986	histidine ammonia-lyase
C5O00_RS12280	COG0542	response to heat
C5O00_RS12295	COG0791	NLP P60 protein
C5O00_RS12300	COG0183	Belongs to the thiolase family
C5O00_RS12310	COG0363	glucosamine-6-phosphate deaminase activity
C5O00_RS12320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5O00_RS12365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C5O00_RS12375	COG0251	oxidation-reduction process
C5O00_RS12385	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5O00_RS12390	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C5O00_RS12395	COG2181	nitrate reductase activity
C5O00_RS12395	COG0247	lactate metabolic process
C5O00_RS12405	COG2181	nitrate reductase activity
C5O00_RS12405	COG0247	lactate metabolic process
C5O00_RS12415	COG1472	Belongs to the glycosyl hydrolase 3 family
C5O00_RS12420	COG0438	transferase activity, transferring glycosyl groups
C5O00_RS12440	COG0247	lactate metabolic process
C5O00_RS12440	COG0277	FAD linked oxidase domain protein
C5O00_RS12445	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C5O00_RS12450	COG1301	dicarboxylic acid transport
C5O00_RS12460	COG0668	transmembrane transport
C5O00_RS12465	COG0189	ligase activity
C5O00_RS12480	COG3011	Protein conserved in bacteria
C5O00_RS12485	COG1193	negative regulation of DNA recombination
C5O00_RS12490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C5O00_RS12520	COG0022	dehydrogenase e1 component
C5O00_RS12550	COG1028	Short-chain dehydrogenase reductase Sdr
C5O00_RS12560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5O00_RS12565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5O00_RS12570	COG0861	Integral membrane protein TerC family
C5O00_RS12575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C5O00_RS12595	COG3386	PFAM SMP-30 Gluconolaconase
C5O00_RS12600	COG2353	YceI-like domain
C5O00_RS12625	COG2814	Major facilitator Superfamily
C5O00_RS12630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5O00_RS12705	COG0577	efflux transmembrane transporter activity
C5O00_RS12705	COG1136	(ABC) transporter
C5O00_RS12710	COG4181	ATPase activity
C5O00_RS12720	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C5O00_RS12720	COG3264	Mechanosensitive ion channel
C5O00_RS12725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5O00_RS12730	COG1064	alcohol dehydrogenase
C5O00_RS12740	COG4771	TonB-dependent receptor
C5O00_RS12810	COG1595	DNA-templated transcription, initiation
C5O00_RS12820	COG2234	aminopeptidase activity
C5O00_RS12915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5O00_RS12920	COG1360	Flagellar Motor Protein
C5O00_RS12940	COG0612	Peptidase, M16
C5O00_RS12945	COG2814	Major facilitator Superfamily
C5O00_RS12950	COG0668	transmembrane transport
C5O00_RS12955	COG1607	acyl-coa hydrolase
C5O00_RS12970	COG1012	belongs to the aldehyde dehydrogenase family
C5O00_RS13000	COG0598	Magnesium transport protein CorA
C5O00_RS13005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C5O00_RS13005	COG0140	phosphoribosyl-ATP diphosphatase activity
C5O00_RS13010	COG0107	imidazoleglycerol-phosphate synthase activity
C5O00_RS13015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C5O00_RS13025	COG0131	Imidazoleglycerol-phosphate dehydratase
C5O00_RS13025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C5O00_RS13030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5O00_RS13035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C5O00_RS13040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C5O00_RS13070	COG1028	Short-chain dehydrogenase reductase Sdr
C5O00_RS13075	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C5O00_RS13085	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5O00_RS13090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C5O00_RS13095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5O00_RS13100	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C5O00_RS13100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C5O00_RS13105	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5O00_RS13110	COG1078	dGTPase activity
C5O00_RS13115	COG2204	response regulator
C5O00_RS13150	COG0506	proline dehydrogenase activity
C5O00_RS13155	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C5O00_RS13170	COG1522	sequence-specific DNA binding
C5O00_RS13205	COG0012	GTP binding
C5O00_RS13220	COG1073	alpha beta
C5O00_RS13265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5O00_RS13270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5O00_RS13280	COG4191	Histidine kinase
C5O00_RS13285	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C5O00_RS13295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5O00_RS13305	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C5O00_RS13310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5O00_RS13330	COG4771	TonB-dependent receptor
C5O00_RS13340	COG0302	gtp cyclohydrolase
C5O00_RS13345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5O00_RS13355	COG1136	(ABC) transporter
C5O00_RS13370	COG4251	negative regulation of phosphorylation
C5O00_RS13380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5O00_RS13405	COG0321	lipoyl(octanoyl) transferase activity
C5O00_RS13405	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C5O00_RS13430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C5O00_RS13435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C5O00_RS13440	COG1595	DNA-templated transcription, initiation
C5O00_RS13445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5O00_RS13465	COG0438	transferase activity, transferring glycosyl groups
C5O00_RS13490	COG0156	8-amino-7-oxononanoate synthase activity
C5O00_RS13505	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C5O00_RS13520	COG3422	double-strand break repair
C5O00_RS13575	COG1393	Belongs to the ArsC family
C5O00_RS13595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C5O00_RS13595	COG1333	cytochrome c biogenesis protein
C5O00_RS13620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5O00_RS13625	COG0424	maF-like protein
C5O00_RS13675	COG1028	Short-chain dehydrogenase reductase Sdr
C5O00_RS13680	COG0415	Belongs to the DNA photolyase family
C5O00_RS13695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5O00_RS13715	COG0514	ATP-dependent DNA helicase (RecQ)
C5O00_RS13720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5O00_RS13730	COG1678	Uncharacterized ACR, COG1678
C5O00_RS13735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5O00_RS13935	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5O00_RS14035	COG0124	histidyl-tRNA synthetase
C5O00_RS14050	COG0359	binds to the 23S rRNA
C5O00_RS14055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5O00_RS14060	COG0360	Binds together with S18 to 16S ribosomal RNA
C5O00_RS14065	COG3279	Response regulator of the LytR AlgR family
C5O00_RS14070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C5O00_RS14090	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C5O00_RS14095	COG4941	Belongs to the sigma-70 factor family
C5O00_RS14105	COG1012	belongs to the aldehyde dehydrogenase family
C5O00_RS14120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C5O00_RS14140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C5O00_RS14170	COG1595	DNA-templated transcription, initiation
C5O00_RS14190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5O00_RS14195	COG1120	ATPase activity
C5O00_RS14205	COG1607	acyl-coa hydrolase
C5O00_RS14240	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C5O00_RS14275	COG1741	Belongs to the pirin family
C5O00_RS14285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5O00_RS14310	COG0254	rRNA binding
C5O00_RS14325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5O00_RS14330	COG1132	(ABC) transporter
C5O00_RS14355	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C5O00_RS14355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5O00_RS14370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5O00_RS14370	COG0047	phosphoribosylformylglycinamidine synthase activity
C5O00_RS14375	COG1022	Amp-dependent synthetase and ligase
C5O00_RS14395	COG1024	Enoyl-CoA hydratase
C5O00_RS14395	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5O00_RS14400	COG0183	Belongs to the thiolase family
C5O00_RS14405	COG1960	acyl-CoA dehydrogenase activity
C5O00_RS14420	COG2234	aminopeptidase activity