locus-tag	class	description
DCC27_RS00010	COG0142	geranyltranstransferase activity
DCC27_RS00020	COG0537	adenosine 5'-monophosphoramidase activity
DCC27_RS00035	COG0501	Belongs to the peptidase M48B family
DCC27_RS00045	COG1666	GTP binding
DCC27_RS00055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DCC27_RS00080	COG5646	InterPro IPR014922
DCC27_RS00130	COG2056	Na+-H+ antiporter family
DCC27_RS00135	COG1760	l-serine dehydratase
DCC27_RS00150	COG2030	dehydratase
DCC27_RS00155	COG2030	dehydratase
DCC27_RS00160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DCC27_RS00165	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DCC27_RS00175	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DCC27_RS00180	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DCC27_RS00190	COG0494	nUDIX hydrolase
DCC27_RS00190	COG0406	alpha-ribazole phosphatase activity
DCC27_RS00195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DCC27_RS00195	COG0456	acetyltransferase
DCC27_RS00210	COG3485	protocatechuate 3,4-dioxygenase
DCC27_RS00230	COG0436	Aminotransferase
DCC27_RS00240	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DCC27_RS00245	COG0250	Participates in transcription elongation, termination and antitermination
DCC27_RS00250	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DCC27_RS00255	COG0081	regulation of translation
DCC27_RS00260	COG1113	amino acid transport
DCC27_RS00265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DCC27_RS00270	COG0222	ribosome binding
DCC27_RS00275	COG0085	RNA polymerase activity
DCC27_RS00280	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DCC27_RS00310	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DCC27_RS00315	COG0049	tRNA binding
DCC27_RS00320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DCC27_RS00325	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DCC27_RS00330	COG0051	transcription antitermination factor activity, RNA binding
DCC27_RS00335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DCC27_RS00340	COG0088	Forms part of the polypeptide exit tunnel
DCC27_RS00345	COG0089	rRNA binding
DCC27_RS00350	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DCC27_RS00355	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DCC27_RS00360	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DCC27_RS00365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DCC27_RS00370	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DCC27_RS00375	COG0255	Belongs to the universal ribosomal protein uL29 family
DCC27_RS00380	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DCC27_RS00385	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DCC27_RS00395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DCC27_RS00400	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DCC27_RS00405	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DCC27_RS00415	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DCC27_RS00420	COG1841	ribosomal large subunit assembly
DCC27_RS00425	COG0200	Binds to the 23S rRNA
DCC27_RS00435	COG0563	adenylate kinase activity
DCC27_RS00445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DCC27_RS00450	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DCC27_RS00455	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DCC27_RS00460	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DCC27_RS00465	COG0202	RNA polymerase activity
DCC27_RS00470	COG0203	ribosomal protein L17
DCC27_RS00475	COG0101	tRNA pseudouridine synthase activity
DCC27_RS00480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DCC27_RS00485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DCC27_RS00490	COG1126	abc transporter atp-binding protein
DCC27_RS00495	COG0765	amino acid transport
DCC27_RS00500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DCC27_RS00510	COG1970	mechanosensitive ion channel activity
DCC27_RS00520	COG1072	(Pantothenic acid kinase))
DCC27_RS00530	COG0736	holo-[acyl-carrier-protein] synthase activity
DCC27_RS00535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DCC27_RS00535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DCC27_RS00540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DCC27_RS00560	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DCC27_RS00565	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DCC27_RS00595	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DCC27_RS00600	COG0459	protein refolding
DCC27_RS00605	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DCC27_RS00605	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DCC27_RS00610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DCC27_RS00615	COG0509	glycine decarboxylation via glycine cleavage system
DCC27_RS00620	COG1090	epimerase
DCC27_RS00630	COG0516	GMP reductase activity
DCC27_RS00645	COG0586	Pfam SNARE associated Golgi protein
DCC27_RS00650	COG0519	Catalyzes the synthesis of GMP from XMP
DCC27_RS00650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DCC27_RS00670	COG0488	(ABC) transporter
DCC27_RS00695	COG3547	Transposase (IS116 IS110 IS902 family)
DCC27_RS00755	COG1722	exodeoxyribonuclease VII activity
DCC27_RS00760	COG1570	exodeoxyribonuclease VII activity
DCC27_RS00770	COG0471	metal ion transport
DCC27_RS00775	COG2197	response regulator
DCC27_RS00780	COG4585	Histidine kinase
DCC27_RS00790	COG1131	(ABC) transporter
DCC27_RS00795	COG1028	Short-chain dehydrogenase reductase Sdr
DCC27_RS00815	COG1012	belongs to the aldehyde dehydrogenase family
DCC27_RS00820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DCC27_RS00825	COG0012	GTP binding
DCC27_RS00860	COG1396	sequence-specific DNA binding
DCC27_RS00905	COG1136	(ABC) transporter
DCC27_RS00915	COG0667	Aldo Keto reductase
DCC27_RS00930	COG1028	Short-chain dehydrogenase reductase Sdr
DCC27_RS00935	COG0596	Alpha beta hydrolase
DCC27_RS00950	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DCC27_RS00955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DCC27_RS00960	COG3842	ATPase activity
DCC27_RS00970	COG0395	ABC-type sugar transport system, permease component
DCC27_RS00975	COG1175	transmembrane transport
DCC27_RS00980	COG2807	transmembrane transport
DCC27_RS00985	COG1217	gtp-binding protein TYPA
DCC27_RS01020	COG1611	Belongs to the LOG family
DCC27_RS01045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DCC27_RS01065	COG0006	proline dipeptidase activity
DCC27_RS01070	COG0613	PHP domain protein
DCC27_RS01090	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DCC27_RS01095	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DCC27_RS01100	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
DCC27_RS01105	COG3253	May function as heme-dependent peroxidase
DCC27_RS01110	COG0181	hydroxymethylbilane synthase activity
DCC27_RS01125	COG0113	porphobilinogen synthase activity
DCC27_RS01130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DCC27_RS01180	COG3480	Lon protease (S16) C-terminal proteolytic domain
DCC27_RS01185	COG1615	UPF0182 protein
DCC27_RS01200	COG0803	Belongs to the bacterial solute-binding protein 9 family
DCC27_RS01210	COG1121	(ABC) transporter
DCC27_RS01215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DCC27_RS01220	COG1842	Phage shock protein A
DCC27_RS01230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DCC27_RS01235	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DCC27_RS01245	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DCC27_RS01260	COG0482	sulfurtransferase activity
DCC27_RS01280	COG0714	Associated with various cellular activities
DCC27_RS01300	COG0745	RESPONSE REGULATOR receiver
DCC27_RS01305	COG5000	phosphorelay sensor kinase activity
DCC27_RS01305	COG5002	protein histidine kinase activity
DCC27_RS01310	COG5401	PFAM Sporulation and spore germination
DCC27_RS01315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DCC27_RS01320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DCC27_RS01325	COG0653	protein targeting
DCC27_RS01355	COG0489	protein tyrosine kinase activity
DCC27_RS01360	COG2902	Dehydrogenase
DCC27_RS01385	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DCC27_RS01390	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DCC27_RS01395	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DCC27_RS01400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DCC27_RS01405	COG1674	ftsk spoiiie
DCC27_RS01445	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DCC27_RS01450	COG2884	Cell division ATP-binding protein ftsE
DCC27_RS01455	COG2177	Part of the ABC transporter FtsEX involved in
DCC27_RS01465	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DCC27_RS01475	COG1114	Component of the transport system for branched-chain amino acids
DCC27_RS01500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DCC27_RS01505	COG0483	inositol monophosphate 1-phosphatase activity
DCC27_RS01515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DCC27_RS01520	COG1595	DNA-templated transcription, initiation
DCC27_RS01540	COG0567	Dehydrogenase, E1 component
DCC27_RS01540	COG0508	dehydrogenase complex catalyzes the overall conversion of
DCC27_RS01545	COG0517	IMP dehydrogenase activity
DCC27_RS01545	COG0516	GMP reductase activity
DCC27_RS01550	COG1253	flavin adenine dinucleotide binding
DCC27_RS01555	COG1253	flavin adenine dinucleotide binding
DCC27_RS01565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DCC27_RS01570	COG1121	(ABC) transporter
DCC27_RS01590	COG0537	adenosine 5'-monophosphoramidase activity
DCC27_RS01595	COG1643	Atp-dependent helicase
DCC27_RS01605	COG0018	arginyl-trna synthetase
DCC27_RS01610	COG0019	diaminopimelate decarboxylase activity
DCC27_RS01615	COG0460	homoserine dehydrogenase
DCC27_RS01620	COG0083	homoserine kinase activity
DCC27_RS01630	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DCC27_RS01635	COG2890	protein-(glutamine-N5) methyltransferase activity
DCC27_RS01655	COG0356	it plays a direct role in the translocation of protons across the membrane
DCC27_RS01660	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DCC27_RS01665	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DCC27_RS01670	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DCC27_RS01675	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DCC27_RS01680	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DCC27_RS01685	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DCC27_RS01690	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DCC27_RS01700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DCC27_RS01705	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DCC27_RS01740	COG1335	isochorismatase
DCC27_RS01750	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DCC27_RS01760	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DCC27_RS01765	COG1234	tRNA 3'-trailer cleavage
DCC27_RS01770	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DCC27_RS01775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DCC27_RS01790	COG0420	3'-5' exonuclease activity
DCC27_RS01795	COG0419	ATPase involved in DNA repair
DCC27_RS01800	COG0579	oxidoreductase
DCC27_RS01835	COG0385	Bile acid
DCC27_RS01845	COG2873	o-acetylhomoserine
DCC27_RS01855	COG2391	methyltransferase activity
DCC27_RS01860	COG4172	Belongs to the ABC transporter superfamily
DCC27_RS01865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DCC27_RS01880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DCC27_RS01885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DCC27_RS01890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DCC27_RS01905	COG0129	dihydroxy-acid dehydratase activity
DCC27_RS01915	COG0440	acetolactate synthase activity
DCC27_RS01920	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DCC27_RS01925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DCC27_RS01935	COG0473	3-isopropylmalate dehydrogenase activity
DCC27_RS01940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DCC27_RS01945	COG0179	Fumarylacetoacetate (FAA) hydrolase
DCC27_RS01950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DCC27_RS01970	COG1414	Transcriptional regulator
DCC27_RS01975	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DCC27_RS01980	COG0066	3-isopropylmalate dehydratase activity
DCC27_RS01985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DCC27_RS01995	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DCC27_RS02000	COG1181	Belongs to the D-alanine--D-alanine ligase family
DCC27_RS02010	COG1461	Dihydroxyacetone kinase
DCC27_RS02030	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DCC27_RS02040	COG2755	lipolytic protein G-D-S-L family
DCC27_RS02040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DCC27_RS02055	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DCC27_RS02065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DCC27_RS02070	COG1316	TRANSCRIPTIONal
DCC27_RS02075	COG0438	transferase activity, transferring glycosyl groups
DCC27_RS02080	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DCC27_RS02085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DCC27_RS02100	COG1134	teichoic acid transport
DCC27_RS02115	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DCC27_RS02120	COG1196	nuclear chromosome segregation
DCC27_RS02125	COG0477	Major facilitator Superfamily
DCC27_RS02145	COG0228	four-way junction DNA binding
DCC27_RS02150	COG1837	Belongs to the UPF0109 family
DCC27_RS02155	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DCC27_RS02160	COG0336	Belongs to the RNA methyltransferase TrmD family
DCC27_RS02165	COG0335	large ribosomal subunit rRNA binding
DCC27_RS02170	COG0681	Belongs to the peptidase S26 family
DCC27_RS02175	COG0681	Belongs to the peptidase S26 family
DCC27_RS02180	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DCC27_RS02190	COG0792	nuclease activity
DCC27_RS02205	COG4974	Belongs to the 'phage' integrase family
DCC27_RS02220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DCC27_RS02225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DCC27_RS02240	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DCC27_RS02265	COG2326	polyphosphate kinase activity
DCC27_RS02270	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DCC27_RS02280	COG1045	serine acetyltransferase
DCC27_RS02290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DCC27_RS02295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DCC27_RS02305	COG3022	response to hydroperoxide
DCC27_RS02325	COG0242	peptide deformylase activity
DCC27_RS02330	COG2329	Antibiotic biosynthesis monooxygenase
DCC27_RS02345	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DCC27_RS02390	COG0629	single-stranded DNA binding
DCC27_RS02425	COG0698	ribose 5-phosphate isomerase
DCC27_RS02435	COG0321	lipoyl(octanoyl) transferase activity
DCC27_RS02440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DCC27_RS02455	COG0544	peptidyl-prolyl cis-trans isomerase activity
DCC27_RS02460	COG0740	serine-type endopeptidase activity
DCC27_RS02465	COG0740	serine-type endopeptidase activity
DCC27_RS02470	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DCC27_RS02475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DCC27_RS02480	COG0525	valine-tRNA ligase activity
DCC27_RS02485	COG4221	oxidoreductase activity
DCC27_RS02490	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DCC27_RS02495	COG0285	dihydrofolate synthase activity
DCC27_RS02505	COG0105	UTP biosynthetic process
DCC27_RS02520	COG1530	ribonuclease E activity
DCC27_RS02525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DCC27_RS02530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DCC27_RS02535	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DCC27_RS02540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DCC27_RS02555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DCC27_RS02565	COG0799	negative regulation of ribosome biogenesis
DCC27_RS02570	COG0406	alpha-ribazole phosphatase activity
DCC27_RS02585	COG3547	Transposase (IS116 IS110 IS902 family)
DCC27_RS02605	COG0577	efflux transmembrane transporter activity
DCC27_RS02605	COG1136	(ABC) transporter
DCC27_RS02620	COG4585	Histidine kinase
DCC27_RS02625	COG2197	response regulator
DCC27_RS02635	COG0515	serine threonine protein kinase
DCC27_RS02650	COG1505	serine-type exopeptidase activity
DCC27_RS02660	COG0587	DNA-directed DNA polymerase activity
DCC27_RS02680	COG4221	oxidoreductase activity
DCC27_RS02690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DCC27_RS02740	COG1309	transcriptional regulator
DCC27_RS02780	COG3173	Aminoglycoside phosphotransferase
DCC27_RS02805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DCC27_RS02815	COG1960	acyl-CoA dehydrogenase activity
DCC27_RS02825	COG1309	transcriptional regulator
DCC27_RS02835	COG0798	PFAM Bile acid sodium symporter
DCC27_RS02845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DCC27_RS02875	COG2826	transposase and inactivated derivatives, IS30 family
DCC27_RS02880	COG2801	Transposase and inactivated derivatives
DCC27_RS02920	COG0471	metal ion transport
DCC27_RS02925	COG0471	metal ion transport
DCC27_RS02930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DCC27_RS02940	COG1126	abc transporter atp-binding protein
DCC27_RS02960	COG4868	Belongs to the UPF0371 family
DCC27_RS02965	COG0561	phosphatase activity
DCC27_RS02980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DCC27_RS02985	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DCC27_RS03005	COG2135	peptidase activity
DCC27_RS03015	COG0587	DNA-directed DNA polymerase activity
DCC27_RS03030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DCC27_RS03090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DCC27_RS03100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DCC27_RS03110	COG0140	phosphoribosyl-ATP diphosphatase activity
DCC27_RS03115	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DCC27_RS03120	COG0107	imidazoleglycerol-phosphate synthase activity
DCC27_RS03130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DCC27_RS03150	COG0134	indole-3-glycerol-phosphate synthase activity
DCC27_RS03155	COG0133	tryptophan synthase activity
DCC27_RS03160	COG0159	tryptophan synthase activity
DCC27_RS03165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DCC27_RS03190	COG2111	Na H antiporter
DCC27_RS03190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DCC27_RS03200	COG0651	ATP synthesis coupled electron transport
DCC27_RS03205	COG1863	multisubunit Na H antiporter MnhE subunit
DCC27_RS03225	COG0539	negative regulation of cytoplasmic translation
DCC27_RS03230	COG0135	phosphoribosylanthranilate isomerase activity
DCC27_RS03240	COG1739	Uncharacterized protein family UPF0029
DCC27_RS03245	COG0237	dephospho-CoA kinase activity
DCC27_RS03250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DCC27_RS03250	COG2755	lipolytic protein G-D-S-L family
DCC27_RS03255	COG0556	nucleotide-excision repair
DCC27_RS03275	COG4106	trans-aconitate 2-methyltransferase activity
DCC27_RS03295	COG0204	Acyl-transferase
DCC27_RS03295	COG0318	PFAM AMP-dependent synthetase and ligase
DCC27_RS03300	COG0322	excinuclease ABC activity
DCC27_RS03305	COG1660	Displays ATPase and GTPase activities
DCC27_RS03315	COG1481	regulation of sporulation
DCC27_RS03325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DCC27_RS03330	COG0126	phosphoglycerate kinase activity
DCC27_RS03335	COG0149	triose-phosphate isomerase activity
DCC27_RS03340	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DCC27_RS03345	COG0363	glucosamine-6-phosphate deaminase activity
DCC27_RS03360	COG0166	Belongs to the GPI family
DCC27_RS03365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DCC27_RS03375	COG0109	protoheme IX farnesyltransferase activity
DCC27_RS03410	COG0719	Fe-S assembly protein
DCC27_RS03415	COG0396	ATPase activity
DCC27_RS03420	COG2151	metal-sulfur cluster biosynthetic enzyme
DCC27_RS03430	COG0328	RNA-DNA hybrid ribonuclease activity
DCC27_RS03435	COG0488	(ABC) transporter
DCC27_RS03465	COG1028	Short-chain dehydrogenase reductase Sdr
DCC27_RS03470	COG0560	Phosphoserine phosphatase
DCC27_RS03470	COG3830	Belongs to the UPF0237 family
DCC27_RS03475	COG1119	ATPase activity
DCC27_RS03490	COG0254	rRNA binding
DCC27_RS03500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DCC27_RS03525	COG1757	Na H antiporter
DCC27_RS03535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DCC27_RS03540	COG0297	glycogen (starch) synthase activity
DCC27_RS03555	COG0183	Belongs to the thiolase family
DCC27_RS03560	COG1028	Short-chain dehydrogenase reductase Sdr
DCC27_RS03570	COG0438	transferase activity, transferring glycosyl groups
DCC27_RS03590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DCC27_RS03595	COG1960	acyl-CoA dehydrogenase activity
DCC27_RS03610	COG1968	undecaprenyl-diphosphatase activity
DCC27_RS03615	COG0215	cysteine-tRNA ligase activity
DCC27_RS03625	COG0546	phosphoglycolate phosphatase activity
DCC27_RS03630	COG0517	IMP dehydrogenase activity
DCC27_RS03630	COG1994	Peptidase M50
DCC27_RS03640	COG1222	aaa ATPase
DCC27_RS03645	COG4122	O-methyltransferase activity
DCC27_RS03655	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DCC27_RS03670	COG2378	regulation of single-species biofilm formation
DCC27_RS03675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DCC27_RS03680	COG0805	protein transport
DCC27_RS03685	COG4581	dead DEAH box helicase
DCC27_RS03695	COG1216	Glycosyl transferase, family 2
DCC27_RS03720	COG0710	3-dehydroquinate dehydratase activity
DCC27_RS03740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DCC27_RS03750	COG1845	cytochrome c oxidase, subunit III
DCC27_RS03755	COG2010	Cytochrome c
DCC27_RS03760	COG0723	plastoquinol--plastocyanin reductase activity
DCC27_RS03765	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DCC27_RS03770	COG2130	NADP-dependent
DCC27_RS03790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DCC27_RS03810	COG2130	NADP-dependent
DCC27_RS03820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DCC27_RS03825	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DCC27_RS03850	COG0167	dihydroorotate dehydrogenase activity
DCC27_RS03860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DCC27_RS03865	COG1381	Involved in DNA repair and RecF pathway recombination
DCC27_RS03870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DCC27_RS03875	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DCC27_RS03885	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DCC27_RS03900	COG0484	heat shock protein binding
DCC27_RS03905	COG1420	regulation of RNA biosynthetic process
DCC27_RS03925	COG0481	GTPase activity
DCC27_RS03930	COG0268	Binds directly to 16S ribosomal RNA
DCC27_RS03935	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DCC27_RS03940	COG1473	amidohydrolase
DCC27_RS03990	COG1674	ftsk spoiiie
DCC27_RS04015	COG2333	competence protein COMEC
DCC27_RS04015	COG0658	competence protein
DCC27_RS04020	COG1555	photosystem II stabilization
DCC27_RS04020	COG1596	polysaccharide export
DCC27_RS04025	COG1307	EDD domain protein, DegV family
DCC27_RS04030	COG0495	leucyl-tRNA aminoacylation
DCC27_RS04040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DCC27_RS04050	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DCC27_RS04055	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DCC27_RS04075	COG1758	RNA polymerase activity
DCC27_RS04080	COG0194	GDP metabolic process
DCC27_RS04090	COG0284	orotidine-5'-phosphate decarboxylase activity
DCC27_RS04095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DCC27_RS04110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DCC27_RS04115	COG0540	Belongs to the ATCase OTCase family
DCC27_RS04120	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DCC27_RS04125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DCC27_RS04130	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DCC27_RS04135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DCC27_RS04145	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DCC27_RS04150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DCC27_RS04155	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DCC27_RS04160	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DCC27_RS04165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DCC27_RS04175	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DCC27_RS04185	COG1490	D-aminoacyl-tRNA deacylase activity
DCC27_RS04195	COG0488	(ABC) transporter
DCC27_RS04205	COG2814	Major facilitator Superfamily
DCC27_RS04245	COG1131	(ABC) transporter
DCC27_RS04260	COG1309	transcriptional regulator
DCC27_RS04280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DCC27_RS04285	COG0124	histidyl-tRNA synthetase
DCC27_RS04290	COG1196	nuclear chromosome segregation
DCC27_RS04300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DCC27_RS04305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DCC27_RS04310	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DCC27_RS04320	COG2255	four-way junction helicase activity
DCC27_RS04325	COG0632	four-way junction helicase activity
DCC27_RS04330	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DCC27_RS04335	COG0217	transcriptional regulatory protein
DCC27_RS04345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DCC27_RS04355	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DCC27_RS04375	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DCC27_RS04380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DCC27_RS04390	COG0756	dUTP diphosphatase activity
DCC27_RS04425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DCC27_RS04430	COG4988	ABC transporter
DCC27_RS04435	COG1294	oxidase, subunit
DCC27_RS04440	COG1271	oxidase subunit
DCC27_RS04465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DCC27_RS04470	COG0187	DNA topoisomerase II activity
DCC27_RS04480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DCC27_RS04495	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DCC27_RS04500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DCC27_RS04505	COG0508	dehydrogenase complex catalyzes the overall conversion of
DCC27_RS04530	COG0174	glutamine synthetase
DCC27_RS04535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DCC27_RS04540	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DCC27_RS04545	COG0174	glutamine synthetase
DCC27_RS04550	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DCC27_RS04555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DCC27_RS04570	COG1940	carbohydrate kinase activity
DCC27_RS04575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DCC27_RS04580	COG0587	DNA-directed DNA polymerase activity
DCC27_RS04590	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DCC27_RS04595	COG3599	regulation of cell shape
DCC27_RS04605	COG1799	cell septum assembly
DCC27_RS04610	COG1496	oxidoreductase activity
DCC27_RS04615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DCC27_RS04620	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DCC27_RS04625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DCC27_RS04630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DCC27_RS04640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DCC27_RS04645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DCC27_RS04655	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DCC27_RS04660	COG0768	penicillin binding
DCC27_RS04670	COG0275	rRNA processing
DCC27_RS04675	COG2001	Belongs to the MraZ family
DCC27_RS04690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DCC27_RS04695	COG0142	geranyltranstransferase activity
DCC27_RS04705	COG3942	CHAP domain
DCC27_RS04705	COG1388	LysM domain
DCC27_RS04710	COG0515	serine threonine protein kinase
DCC27_RS04710	COG2815	serine threonine protein kinase
DCC27_RS04715	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DCC27_RS04730	COG1022	Amp-dependent synthetase and ligase
DCC27_RS04740	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DCC27_RS04760	COG1716	ATPase activity
DCC27_RS04770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DCC27_RS04775	COG1160	GTP binding
DCC27_RS04780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DCC27_RS04795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DCC27_RS04820	COG0497	DNA recombination
DCC27_RS04825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DCC27_RS04835	COG0647	UMP catabolic process
DCC27_RS04845	COG0508	dehydrogenase complex catalyzes the overall conversion of
DCC27_RS04850	COG0022	dehydrogenase e1 component
DCC27_RS04855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DCC27_RS04875	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DCC27_RS04885	COG0165	Argininosuccinate lyase
DCC27_RS04895	COG1438	arginine binding
DCC27_RS04900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DCC27_RS04905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DCC27_RS04910	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DCC27_RS04915	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DCC27_RS04920	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DCC27_RS04930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DCC27_RS04930	COG0072	phenylalanine-tRNA ligase activity
DCC27_RS04935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DCC27_RS04955	COG0183	Belongs to the thiolase family
DCC27_RS04960	COG0318	PFAM AMP-dependent synthetase and ligase
DCC27_RS04965	COG1309	transcriptional regulator
DCC27_RS04970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DCC27_RS04980	COG1960	acyl-CoA dehydrogenase activity
DCC27_RS05000	COG0583	DNA-binding transcription factor activity
DCC27_RS05010	COG0352	thiamine-phosphate diphosphorylase activity
DCC27_RS05010	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DCC27_RS05010	COG0351	phosphomethylpyrimidine kinase
DCC27_RS05015	COG0351	phosphomethylpyrimidine kinase
DCC27_RS05020	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DCC27_RS05040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DCC27_RS05050	COG0010	Belongs to the arginase family
DCC27_RS05055	COG1228	amidohydrolase
DCC27_RS05060	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DCC27_RS05070	COG3314	Sporulation integral membrane protein YlbJ
DCC27_RS05100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DCC27_RS05105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DCC27_RS05110	COG0131	Imidazoleglycerol-phosphate dehydratase
DCC27_RS05115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DCC27_RS05120	COG1388	LysM domain
DCC27_RS05125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DCC27_RS05130	COG0471	metal ion transport
DCC27_RS05140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DCC27_RS05145	COG2813	Specifically methylates the guanine in position
DCC27_RS05155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DCC27_RS05160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DCC27_RS05170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DCC27_RS05180	COG1396	sequence-specific DNA binding
DCC27_RS05185	COG1546	Belongs to the CinA family
DCC27_RS05185	COG1058	Belongs to the CinA family
DCC27_RS05195	COG1674	ftsk spoiiie
DCC27_RS05200	COG0662	Cupin 2, conserved barrel domain protein
DCC27_RS05205	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DCC27_RS05210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DCC27_RS05225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DCC27_RS05230	COG1115	amino acid carrier protein
DCC27_RS05235	COG2826	transposase and inactivated derivatives, IS30 family
DCC27_RS05270	COG4133	protoheme IX ABC transporter activity
DCC27_RS05295	COG2963	transposase activity
DCC27_RS05310	COG2826	transposase and inactivated derivatives, IS30 family
DCC27_RS05320	COG0612	Peptidase, M16
DCC27_RS05330	COG1185	polyribonucleotide nucleotidyltransferase activity
DCC27_RS05335	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DCC27_RS05370	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DCC27_RS05375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DCC27_RS05380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DCC27_RS05395	COG0779	Required for maturation of 30S ribosomal subunits
DCC27_RS05405	COG0442	prolyl-tRNA aminoacylation
DCC27_RS05425	COG0750	zinc metalloprotease
DCC27_RS05445	COG0233	cytoplasmic translational termination
DCC27_RS05450	COG0528	UMP kinase activity
DCC27_RS05455	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DCC27_RS05460	COG0052	Belongs to the universal ribosomal protein uS2 family
DCC27_RS05465	COG0745	RESPONSE REGULATOR receiver
DCC27_RS05470	COG2205	protein histidine kinase activity
DCC27_RS05500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DCC27_RS05520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DCC27_RS05535	COG0352	thiamine-phosphate diphosphorylase activity
DCC27_RS05540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DCC27_RS05545	COG2801	Transposase and inactivated derivatives
DCC27_RS05545	COG3415	Transposase
DCC27_RS05550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DCC27_RS05550	COG2022	thiamine diphosphate biosynthetic process
DCC27_RS05560	COG2022	thiamine diphosphate biosynthetic process
DCC27_RS05570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DCC27_RS05590	COG0358	DNA primase activity
DCC27_RS05680	COG2226	methyltransferase
DCC27_RS05685	COG0798	PFAM Bile acid sodium symporter
DCC27_RS05690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DCC27_RS05695	COG2072	flavoprotein involved in K transport
DCC27_RS05730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DCC27_RS05735	COG0318	PFAM AMP-dependent synthetase and ligase
DCC27_RS05740	COG1960	acyl-CoA dehydrogenase activity
DCC27_RS05745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DCC27_RS05760	COG1024	Enoyl-CoA hydratase
DCC27_RS05780	COG0423	glycine-tRNA ligase activity
DCC27_RS05790	COG0737	Belongs to the 5'-nucleotidase family
DCC27_RS05800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DCC27_RS05805	COG2873	o-acetylhomoserine
DCC27_RS05810	COG1643	Atp-dependent helicase
DCC27_RS05840	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DCC27_RS05845	COG0154	amidase activity
DCC27_RS05850	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DCC27_RS05865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DCC27_RS05870	COG0631	protein serine/threonine phosphatase activity
DCC27_RS05890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DCC27_RS05900	COG0424	maF-like protein
DCC27_RS05905	COG4770	biotin carboxylase activity
DCC27_RS05910	COG0477	Major facilitator Superfamily
DCC27_RS05925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DCC27_RS05930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DCC27_RS05960	COG1309	transcriptional regulator
DCC27_RS05970	COG0193	aminoacyl-tRNA hydrolase activity
DCC27_RS05975	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DCC27_RS05985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DCC27_RS05995	COG3842	ATPase activity
DCC27_RS06000	COG1178	ABC-type Fe3 transport system permease component
DCC27_RS06015	COG2365	Tyrosine phosphatase family
DCC27_RS06025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DCC27_RS06030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DCC27_RS06040	COG1321	iron dependent repressor
DCC27_RS06040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DCC27_RS06055	COG0519	Catalyzes the synthesis of GMP from XMP
DCC27_RS06065	COG0583	DNA-binding transcription factor activity
DCC27_RS06070	COG0488	(ABC) transporter
DCC27_RS06080	COG2962	Rard protein
DCC27_RS06085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DCC27_RS06115	COG2197	response regulator
DCC27_RS06120	COG4585	Histidine kinase
DCC27_RS06125	COG1131	(ABC) transporter
DCC27_RS06145	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DCC27_RS06160	COG2226	methyltransferase
DCC27_RS06190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DCC27_RS06195	COG1819	glycosyl
DCC27_RS06210	COG0583	DNA-binding transcription factor activity
DCC27_RS06215	COG0488	(ABC) transporter
DCC27_RS06220	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DCC27_RS06225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DCC27_RS06230	COG3583	domain protein
DCC27_RS06235	COG0084	hydrolase, TatD family'
DCC27_RS06240	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DCC27_RS06245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DCC27_RS06260	COG2188	Transcriptional regulator
DCC27_RS06265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DCC27_RS06285	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DCC27_RS06310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DCC27_RS06355	COG1316	TRANSCRIPTIONal
DCC27_RS06360	COG1482	cell wall glycoprotein biosynthetic process
DCC27_RS06375	COG0288	reversible hydration of carbon dioxide
DCC27_RS06380	COG0114	fumarate hydratase activity
DCC27_RS06395	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DCC27_RS06405	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DCC27_RS06410	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DCC27_RS06420	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DCC27_RS06430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DCC27_RS06440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DCC27_RS06500	COG0395	ABC-type sugar transport system, permease component
DCC27_RS06505	COG1175	transmembrane transport
DCC27_RS06510	COG3842	ATPase activity
DCC27_RS06515	COG3547	Transposase (IS116 IS110 IS902 family)
DCC27_RS06520	COG0148	phosphopyruvate hydratase activity
DCC27_RS06530	COG3956	TIGRFAM MazG family protein
DCC27_RS06535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DCC27_RS06555	COG1473	amidohydrolase
DCC27_RS06555	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DCC27_RS06565	COG2009	succinate dehydrogenase
DCC27_RS06580	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DCC27_RS06605	COG3842	ATPase activity
DCC27_RS06615	COG0406	alpha-ribazole phosphatase activity
DCC27_RS06615	COG0494	nUDIX hydrolase
DCC27_RS06700	COG0789	Transcriptional regulator
DCC27_RS06815	COG1674	ftsk spoiiie
DCC27_RS06820	COG0180	Tryptophanyl-tRNA synthetase
DCC27_RS06845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DCC27_RS06850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DCC27_RS06930	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DCC27_RS06930	COG2066	Belongs to the glutaminase family
DCC27_RS06935	COG2838	Isocitrate dehydrogenase
DCC27_RS06940	COG2239	Acts as a magnesium transporter
DCC27_RS06945	COG0138	bifunctional purine biosynthesis protein purh
DCC27_RS06965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DCC27_RS06995	COG2149	membrane
DCC27_RS07005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DCC27_RS07020	COG0045	succinate-CoA ligase (ADP-forming) activity
DCC27_RS07055	COG0791	NLP P60 protein
DCC27_RS07055	COG3103	Sh3 type 3 domain protein
DCC27_RS07055	COG1388	LysM domain
DCC27_RS07065	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DCC27_RS07095	COG0745	RESPONSE REGULATOR receiver
DCC27_RS07100	COG2205	protein histidine kinase activity
DCC27_RS07115	COG0459	protein refolding
DCC27_RS07130	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DCC27_RS07225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DCC27_RS07230	COG0366	Alpha amylase catalytic
DCC27_RS07235	COG1116	anion transmembrane transporter activity
DCC27_RS07235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DCC27_RS07240	COG4211	Belongs to the binding-protein-dependent transport system permease family
DCC27_RS07260	COG0215	cysteine-tRNA ligase activity
DCC27_RS07270	COG0745	RESPONSE REGULATOR receiver
DCC27_RS07275	COG5002	protein histidine kinase activity
DCC27_RS07295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DCC27_RS07295	COG0512	Glutamine amidotransferase of anthranilate synthase
DCC27_RS07300	COG0588	phosphoglycerate mutase activity
DCC27_RS07310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DCC27_RS07315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DCC27_RS07330	COG0473	3-isopropylmalate dehydrogenase activity
DCC27_RS07360	COG3321	synthase
DCC27_RS07360	COG1028	Short-chain dehydrogenase reductase Sdr
DCC27_RS07360	COG0604	alcohol dehydrogenase
DCC27_RS07390	COG2814	Major facilitator Superfamily
DCC27_RS07410	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DCC27_RS07425	COG0745	RESPONSE REGULATOR receiver
DCC27_RS07430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DCC27_RS07450	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DCC27_RS07460	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DCC27_RS07465	COG2079	MmgE PrpD family protein
DCC27_RS07505	COG2963	transposase activity
DCC27_RS07525	COG3547	Transposase (IS116 IS110 IS902 family)
DCC27_RS07530	COG0732	type I restriction modification DNA specificity domain
DCC27_RS07545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DCC27_RS07550	COG0531	amino acid
DCC27_RS07560	COG1715	Restriction endonuclease
DCC27_RS07575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DCC27_RS07580	COG1201	RNA secondary structure unwinding
DCC27_RS07585	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DCC27_RS07590	COG0564	pseudouridine synthase activity
DCC27_RS07605	COG2146	nitrite reductase [NAD(P)H] activity
DCC27_RS07615	COG0343	queuine tRNA-ribosyltransferase activity
DCC27_RS07645	COG2855	membrane
DCC27_RS07655	COG1329	Transcriptional regulator
DCC27_RS07665	COG0598	Magnesium transport protein CorA
DCC27_RS07675	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DCC27_RS07690	COG4175	Glycine betaine
DCC27_RS07690	COG0517	IMP dehydrogenase activity
DCC27_RS07700	COG1012	belongs to the aldehyde dehydrogenase family
DCC27_RS07715	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DCC27_RS07715	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DCC27_RS07720	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DCC27_RS07760	COG0693	protein deglycase activity
DCC27_RS07770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DCC27_RS07790	COG2197	response regulator
DCC27_RS07795	COG4152	abc transporter atp-binding protein
DCC27_RS07820	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DCC27_RS07830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DCC27_RS07840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DCC27_RS07845	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DCC27_RS07860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DCC27_RS07890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DCC27_RS07925	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DCC27_RS07930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DCC27_RS07940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DCC27_RS07950	COG0318	PFAM AMP-dependent synthetase and ligase
DCC27_RS07960	COG0477	Major facilitator Superfamily
DCC27_RS07985	COG1012	belongs to the aldehyde dehydrogenase family
DCC27_RS07995	COG0477	Major facilitator Superfamily
DCC27_RS08010	COG2873	o-acetylhomoserine
DCC27_RS08015	COG1832	CoA-binding protein
DCC27_RS08025	COG0028	Belongs to the TPP enzyme family
DCC27_RS08050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DCC27_RS08055	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DCC27_RS08060	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DCC27_RS08065	COG1435	thymidine kinase activity
DCC27_RS08080	COG0747	negative chemotaxis
DCC27_RS08085	COG0601	transmembrane transport
DCC27_RS08090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DCC27_RS08095	COG3547	Transposase (IS116 IS110 IS902 family)
DCC27_RS08170	COG1136	(ABC) transporter
DCC27_RS08170	COG0577	efflux transmembrane transporter activity
DCC27_RS08195	COG4585	Histidine kinase
DCC27_RS08200	COG2197	response regulator
DCC27_RS08235	COG2197	response regulator
DCC27_RS08240	COG4585	Histidine kinase
DCC27_RS08250	COG1131	(ABC) transporter
DCC27_RS08285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DCC27_RS08290	COG2011	ABC-type metal ion transport system permease component
DCC27_RS08295	COG1464	Belongs to the NlpA lipoprotein family
DCC27_RS08325	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DCC27_RS08345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DCC27_RS08355	COG0366	Alpha amylase catalytic
DCC27_RS08360	COG1321	iron dependent repressor
DCC27_RS08370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DCC27_RS08375	COG0047	phosphoribosylformylglycinamidine synthase activity
DCC27_RS08380	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DCC27_RS08385	COG1250	3-hydroxyacyl-CoA dehydrogenase
DCC27_RS08385	COG1024	Enoyl-CoA hydratase
DCC27_RS08390	COG0183	Belongs to the thiolase family
DCC27_RS08400	COG1174	glycine betaine transport
DCC27_RS08405	COG1125	glycine betaine transport
DCC27_RS08405	COG0517	IMP dehydrogenase activity
DCC27_RS08445	COG1388	LysM domain
DCC27_RS08445	COG3103	Sh3 type 3 domain protein
DCC27_RS08445	COG0791	NLP P60 protein
DCC27_RS08470	COG0857	belongs to the CobB CobQ family
DCC27_RS08470	COG0280	phosphate acetyltransferase
DCC27_RS08475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DCC27_RS08480	COG2733	membrane
DCC27_RS08505	COG5006	permease, DMT superfamily
DCC27_RS08545	COG0306	phosphate transporter
DCC27_RS08555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DCC27_RS08560	COG0581	inorganic phosphate transmembrane transporter activity
DCC27_RS08600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DCC27_RS08605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DCC27_RS08615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DCC27_RS08620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DCC27_RS08655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DCC27_RS08660	COG0583	DNA-binding transcription factor activity
DCC27_RS08700	COG3590	peptidase
DCC27_RS08710	COG0531	amino acid
DCC27_RS08735	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DCC27_RS08735	COG0302	gtp cyclohydrolase
DCC27_RS08745	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DCC27_RS08750	COG0302	gtp cyclohydrolase
DCC27_RS08755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DCC27_RS08765	COG0037	tRNA processing
DCC27_RS08780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DCC27_RS08795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DCC27_RS08800	COG1597	lipid kinase activity
DCC27_RS08805	COG0077	Prephenate dehydratase
DCC27_RS08810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DCC27_RS08810	COG0425	Belongs to the sulfur carrier protein TusA family
DCC27_RS08820	COG1012	belongs to the aldehyde dehydrogenase family
DCC27_RS08855	COG2130	NADP-dependent
DCC27_RS08860	COG0183	Belongs to the thiolase family
DCC27_RS08865	COG1024	Enoyl-CoA hydratase
DCC27_RS08885	COG1960	acyl-CoA dehydrogenase activity
DCC27_RS08890	COG1960	acyl-CoA dehydrogenase activity
DCC27_RS08895	COG0318	PFAM AMP-dependent synthetase and ligase
DCC27_RS08920	COG0604	alcohol dehydrogenase
DCC27_RS08955	COG0561	phosphatase activity
DCC27_RS08960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DCC27_RS08965	COG2233	PERMEase
DCC27_RS08980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DCC27_RS09000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DCC27_RS09010	COG1518	maintenance of DNA repeat elements
DCC27_RS09095	COG0582	viral genome integration into host DNA
DCC27_RS09115	COG1716	ATPase activity
DCC27_RS09130	COG0768	penicillin binding
DCC27_RS09135	COG0515	serine threonine protein kinase
DCC27_RS09140	COG2815	serine threonine protein kinase
DCC27_RS09140	COG0515	serine threonine protein kinase
DCC27_RS09150	COG3764	Sortase (surface protein transpeptidase)
DCC27_RS09175	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DCC27_RS09205	COG1120	ATPase activity
DCC27_RS09210	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DCC27_RS09215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DCC27_RS09220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DCC27_RS09270	COG1122	ATPase activity
DCC27_RS09315	COG2076	Multidrug Resistance protein
DCC27_RS09320	COG0590	tRNA wobble adenosine to inosine editing
DCC27_RS09345	COG1960	acyl-CoA dehydrogenase activity
DCC27_RS09350	COG0662	Cupin 2, conserved barrel domain protein
DCC27_RS09360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DCC27_RS09435	COG1780	Probably involved in ribonucleotide reductase function
DCC27_RS09440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DCC27_RS09445	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DCC27_RS09450	COG0431	NADPH-dependent FMN reductase
DCC27_RS09470	COG3266	domain, Protein
DCC27_RS09475	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DCC27_RS09480	COG0187	DNA topoisomerase II activity
DCC27_RS09485	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DCC27_RS09490	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DCC27_RS09500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DCC27_RS09505	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DCC27_RS09510	COG0594	ribonuclease P activity
DCC27_RS09515	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DCC27_RS09520	COG0706	membrane insertase activity
DCC27_RS09530	COG0357	Ribosomal RNA small subunit methyltransferase G
DCC27_RS09535	COG1192	Involved in chromosome partitioning
DCC27_RS09550	COG0492	ferredoxin-NADP+ reductase activity
DCC27_RS09560	COG0728	peptidoglycan biosynthetic process
DCC27_RS09580	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DCC27_RS09585	COG1260	myo-inositol-1-phosphate synthase
DCC27_RS09595	COG1362	aminopeptidase activity
DCC27_RS09600	COG0360	Binds together with S18 to 16S ribosomal RNA
DCC27_RS09610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DCC27_RS09615	COG0359	binds to the 23S rRNA
DCC27_RS09630	COG0305	Participates in initiation and elongation during chromosome replication
DCC27_RS09640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DCC27_RS09645	COG2357	RelA SpoT domain protein
DCC27_RS09650	COG0436	Aminotransferase
DCC27_RS09675	COG2226	methyltransferase
DCC27_RS09685	COG3949	Membrane
DCC27_RS09700	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DCC27_RS09720	COG1024	Enoyl-CoA hydratase
DCC27_RS09725	COG0318	PFAM AMP-dependent synthetase and ligase
DCC27_RS09730	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
DCC27_RS09770	COG1960	acyl-CoA dehydrogenase activity
DCC27_RS09775	COG1250	3-hydroxyacyl-CoA dehydrogenase
DCC27_RS09780	COG1024	Enoyl-CoA hydratase
DCC27_RS09790	COG1028	Short-chain dehydrogenase reductase Sdr
DCC27_RS09800	COG1136	(ABC) transporter
DCC27_RS09800	COG0577	efflux transmembrane transporter activity
DCC27_RS09815	COG2197	response regulator
DCC27_RS09820	COG4585	Histidine kinase
DCC27_RS09835	COG1121	(ABC) transporter
DCC27_RS09840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DCC27_RS09860	COG0019	diaminopimelate decarboxylase activity
DCC27_RS09880	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DCC27_RS09890	COG1104	cysteine desulfurase activity
DCC27_RS09900	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DCC27_RS09910	COG5285	phytanoyl-CoA dioxygenase
DCC27_RS09915	COG1254	Belongs to the acylphosphatase family
DCC27_RS09920	COG0823	Involved in the tonB-independent uptake of proteins
DCC27_RS09920	COG1506	peptidase
DCC27_RS09930	COG4608	Belongs to the ABC transporter superfamily
DCC27_RS09935	COG0444	Belongs to the ABC transporter superfamily
DCC27_RS09940	COG2801	Transposase and inactivated derivatives
DCC27_RS09940	COG3415	Transposase
DCC27_RS09960	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DCC27_RS09970	COG1254	Belongs to the acylphosphatase family
DCC27_RS09975	COG1506	peptidase
DCC27_RS09975	COG0823	Involved in the tonB-independent uptake of proteins
DCC27_RS09990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DCC27_RS09995	COG4172	Belongs to the ABC transporter superfamily
DCC27_RS10005	COG1131	(ABC) transporter
DCC27_RS10020	COG2197	response regulator
DCC27_RS10025	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DCC27_RS10040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DCC27_RS10050	COG3559	Exporter of polyketide antibiotics
DCC27_RS10055	COG1131	(ABC) transporter
DCC27_RS10060	COG1309	transcriptional regulator
DCC27_RS10065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DCC27_RS10070	COG0154	amidase activity
DCC27_RS10080	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DCC27_RS10090	COG2205	protein histidine kinase activity
DCC27_RS10095	COG0745	RESPONSE REGULATOR receiver
DCC27_RS10100	COG1136	(ABC) transporter
DCC27_RS10100	COG0577	efflux transmembrane transporter activity
DCC27_RS10105	COG1136	(ABC) transporter
DCC27_RS10105	COG0577	efflux transmembrane transporter activity
DCC27_RS10120	COG1250	3-hydroxyacyl-CoA dehydrogenase
DCC27_RS10145	COG0318	PFAM AMP-dependent synthetase and ligase
DCC27_RS10165	COG2851	Citrate transporter
DCC27_RS10175	COG1301	dicarboxylic acid transport
DCC27_RS10180	COG4566	intracellular signal transduction
DCC27_RS10185	COG4191	Histidine kinase
DCC27_RS10190	COG2239	Acts as a magnesium transporter
DCC27_RS10195	COG1960	acyl-CoA dehydrogenase activity
DCC27_RS10205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DCC27_RS10210	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DCC27_RS10220	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DCC27_RS10230	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DCC27_RS10240	COG0765	amino acid transport
DCC27_RS10250	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DCC27_RS10255	COG2217	Heavy metal translocating P-type atpase
DCC27_RS10265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DCC27_RS10270	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DCC27_RS10280	COG1414	Transcriptional regulator
DCC27_RS10285	COG0028	Belongs to the TPP enzyme family
DCC27_RS10295	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DCC27_RS10295	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DCC27_RS10305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DCC27_RS10315	COG1012	belongs to the aldehyde dehydrogenase family
DCC27_RS10325	COG0277	FAD linked oxidase domain protein
DCC27_RS10330	COG3971	2-oxopent-4-enoate hydratase activity
DCC27_RS10355	COG1012	belongs to the aldehyde dehydrogenase family
DCC27_RS10360	COG1785	Belongs to the alkaline phosphatase family
DCC27_RS10400	COG1063	alcohol dehydrogenase
DCC27_RS10410	COG0277	FAD linked oxidase domain protein
DCC27_RS10430	COG2801	Transposase and inactivated derivatives
DCC27_RS10430	COG3415	Transposase
DCC27_RS10490	COG2801	Transposase and inactivated derivatives
DCC27_RS10490	COG3415	Transposase
DCC27_RS10500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DCC27_RS10505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DCC27_RS10510	COG1802	Transcriptional regulator
DCC27_RS10525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DCC27_RS10530	COG2079	MmgE PrpD family protein
DCC27_RS10545	COG1966	Carbon starvation protein
DCC27_RS10560	COG1414	Transcriptional regulator
DCC27_RS10565	COG4948	Mandelate Racemase Muconate Lactonizing
DCC27_RS10570	COG1028	Short-chain dehydrogenase reductase Sdr
DCC27_RS10580	COG4154	Belongs to the RbsD FucU family
DCC27_RS10590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DCC27_RS10600	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DCC27_RS10605	COG2011	ABC-type metal ion transport system permease component
DCC27_RS10610	COG1464	Belongs to the NlpA lipoprotein family
DCC27_RS10675	COG2076	Multidrug Resistance protein
DCC27_RS10680	COG0590	tRNA wobble adenosine to inosine editing
DCC27_RS10685	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DCC27_RS10715	COG3547	Transposase (IS116 IS110 IS902 family)
DCC27_RS10730	COG0028	Belongs to the TPP enzyme family
DCC27_RS10745	COG1268	BioY protein
DCC27_RS10755	COG1122	ATPase activity
DCC27_RS10760	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DCC27_RS10765	COG0667	Aldo Keto reductase
DCC27_RS10770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DCC27_RS10775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DCC27_RS10785	COG2203	Gaf domain
DCC27_RS10785	COG4585	Histidine kinase
DCC27_RS10790	COG2197	response regulator
DCC27_RS10795	COG0604	alcohol dehydrogenase
DCC27_RS10805	COG2608	mercury ion transmembrane transporter activity
DCC27_RS10810	COG1937	Protein conserved in bacteria
DCC27_RS10820	COG3573	Dehydrogenase
DCC27_RS10835	COG3328	transposase activity
DCC27_RS10840	COG2201	protein-glutamate methylesterase activity
DCC27_RS10845	COG1120	ATPase activity
DCC27_RS10850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DCC27_RS10855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DCC27_RS10870	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DCC27_RS10895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DCC27_RS10900	COG0156	8-amino-7-oxononanoate synthase activity
DCC27_RS10905	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DCC27_RS10920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DCC27_RS10940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DCC27_RS10945	COG0477	Major facilitator Superfamily
DCC27_RS10955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DCC27_RS10970	COG1950	PFAM Membrane protein of
DCC27_RS10975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DCC27_RS10985	COG0022	dehydrogenase e1 component
DCC27_RS10990	COG0508	dehydrogenase complex catalyzes the overall conversion of
DCC27_RS11000	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DCC27_RS11005	COG1984	allophanate hydrolase subunit 2
DCC27_RS11010	COG4770	biotin carboxylase activity
DCC27_RS11020	COG4336	lyase activity
DCC27_RS11025	COG1914	H( )-stimulated, divalent metal cation uptake system
DCC27_RS11040	COG0137	argininosuccinate synthase activity
DCC27_RS11050	COG0584	glycerophosphoryl diester phosphodiesterase
DCC27_RS11055	COG1063	alcohol dehydrogenase
DCC27_RS11060	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DCC27_RS11100	COG3425	synthase
DCC27_RS11105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DCC27_RS11125	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DCC27_RS11145	COG0456	acetyltransferase
DCC27_RS11150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DCC27_RS11155	COG1917	Cupin 2, conserved barrel domain protein
DCC27_RS11230	COG3850	Histidine kinase
DCC27_RS11260	COG1012	belongs to the aldehyde dehydrogenase family
DCC27_RS11265	COG0583	DNA-binding transcription factor activity
DCC27_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
DCC27_RS11280	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DCC27_RS11285	COG1396	sequence-specific DNA binding
DCC27_RS11310	COG0477	Major facilitator Superfamily
DCC27_RS11315	COG2957	Belongs to the agmatine deiminase family
DCC27_RS11325	COG1012	belongs to the aldehyde dehydrogenase family
DCC27_RS11330	COG0739	heme binding
DCC27_RS11345	COG1278	Cold shock
DCC27_RS11365	COG0657	acetylesterase activity
DCC27_RS11380	COG1176	ABC-type spermidine putrescine transport system, permease component I
DCC27_RS11385	COG1840	ABC-type Fe3 transport system, periplasmic component
DCC27_RS11395	COG0786	glutamate:sodium symporter activity
DCC27_RS11400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DCC27_RS11425	COG4221	oxidoreductase activity
DCC27_RS11430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DCC27_RS11435	COG0435	Glutathione S-transferase
DCC27_RS11440	COG0252	asparaginase activity
DCC27_RS11445	COG3012	SEC-C Motif Domain Protein
DCC27_RS11460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DCC27_RS11465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DCC27_RS11470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DCC27_RS11475	COG1757	Na H antiporter
DCC27_RS11480	COG0776	regulation of translation
DCC27_RS11495	COG3336	cytochrome c oxidase
DCC27_RS11525	COG0679	Auxin Efflux Carrier
DCC27_RS11540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DCC27_RS11560	COG0789	Transcriptional regulator
DCC27_RS11615	COG0717	Belongs to the dCTP deaminase family
DCC27_RS11625	COG2111	Na H antiporter
DCC27_RS11625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DCC27_RS11630	COG1006	Multisubunit Na H antiporter MnhC subunit
DCC27_RS11635	COG0651	ATP synthesis coupled electron transport
DCC27_RS11650	COG1320	monovalent cation:proton antiporter activity
DCC27_RS11660	COG1929	Belongs to the glycerate kinase type-1 family
DCC27_RS11665	COG2409	Drug exporters of the RND superfamily
DCC27_RS11690	COG0783	Belongs to the Dps family
DCC27_RS11695	COG0443	Heat shock 70 kDa protein
DCC27_RS11700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DCC27_RS11705	COG0484	heat shock protein binding
DCC27_RS11710	COG0789	Transcriptional regulator
DCC27_RS11725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DCC27_RS11735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DCC27_RS11750	COG0542	response to heat
DCC27_RS11765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DCC27_RS11770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DCC27_RS11795	COG0151	Belongs to the GarS family
DCC27_RS11800	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DCC27_RS11805	COG1408	metallophosphoesterase
DCC27_RS11820	COG0251	oxidation-reduction process
DCC27_RS11835	COG0733	neurotransmitter:sodium symporter activity
DCC27_RS11850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DCC27_RS11895	COG1111	helicase
DCC27_RS11895	COG1205	dead DEAH box helicase
DCC27_RS11905	COG1054	Belongs to the UPF0176 family
DCC27_RS11910	COG2890	protein-(glutamine-N5) methyltransferase activity
DCC27_RS11915	COG1754	DNA topoisomerase type I activity
DCC27_RS11915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DCC27_RS11920	COG0248	Ppx GppA phosphatase
DCC27_RS11925	COG1082	Xylose isomerase domain protein TIM barrel
DCC27_RS11930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DCC27_RS11935	COG0569	domain protein
DCC27_RS11940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DCC27_RS11945	COG0123	including yeast histone deacetylase and acetoin utilization protein
DCC27_RS11970	COG0406	alpha-ribazole phosphatase activity
DCC27_RS11975	COG3118	belongs to the thioredoxin family
DCC27_RS11980	COG0785	Cytochrome C biogenesis protein
DCC27_RS11990	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DCC27_RS12020	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DCC27_RS12030	COG2814	Major facilitator Superfamily
DCC27_RS12035	COG1748	Saccharopine dehydrogenase
DCC27_RS12045	COG2252	PERMEase
DCC27_RS12055	COG4948	Mandelate Racemase Muconate Lactonizing
DCC27_RS12060	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)