locus-tag	class	description
DX923_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DX923_RS00010	COG0592	DNA-directed DNA polymerase activity
DX923_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DX923_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DX923_RS00025	COG0187	DNA topoisomerase II activity
DX923_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DX923_RS00045	COG0387	Pfam Sodium calcium exchanger
DX923_RS00060	COG0281	malic enzyme
DX923_RS00085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DX923_RS00100	COG3764	Sortase (surface protein transpeptidase)
DX923_RS00115	COG2815	serine threonine protein kinase
DX923_RS00115	COG0515	serine threonine protein kinase
DX923_RS00120	COG0515	serine threonine protein kinase
DX923_RS00125	COG0768	penicillin binding
DX923_RS00140	COG1716	ATPase activity
DX923_RS00180	COG0697	spore germination
DX923_RS00195	COG2271	Major facilitator Superfamily
DX923_RS00205	COG3842	ATPase activity
DX923_RS00225	COG2205	protein histidine kinase activity
DX923_RS00230	COG0584	glycerophosphoryl diester phosphodiesterase
DX923_RS00235	COG0352	thiamine-phosphate diphosphorylase activity
DX923_RS00245	COG2022	thiamine diphosphate biosynthetic process
DX923_RS00295	COG2313	pseudouridylate synthase activity
DX923_RS00305	COG1525	nuclease
DX923_RS00330	COG2423	ornithine cyclodeaminase activity
DX923_RS00365	COG2258	MOSC domain
DX923_RS00375	COG0730	response to heat
DX923_RS00380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DX923_RS00385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DX923_RS00395	COG0501	Belongs to the peptidase M48B family
DX923_RS00405	COG2130	NADP-dependent
DX923_RS00410	COG1846	Transcriptional regulator
DX923_RS00415	COG1902	pentaerythritol trinitrate reductase activity
DX923_RS00430	COG1668	transmembrane transport
DX923_RS00435	COG4152	abc transporter atp-binding protein
DX923_RS00440	COG2197	response regulator
DX923_RS00470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DX923_RS00490	COG4585	Histidine kinase
DX923_RS00520	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DX923_RS00530	COG2376	Dihydroxyacetone kinase
DX923_RS00535	COG1461	Dihydroxyacetone kinase
DX923_RS00540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DX923_RS00540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DX923_RS00540	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DX923_RS00545	COG0427	acetyl-CoA hydrolase
DX923_RS00575	COG1131	(ABC) transporter
DX923_RS00580	COG0676	glucose-6-phosphate 1-epimerase activity
DX923_RS00585	COG1105	Belongs to the carbohydrate kinase PfkB family
DX923_RS00590	COG0561	phosphatase activity
DX923_RS00615	COG1017	nitric oxide dioxygenase activity
DX923_RS00615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DX923_RS00620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DX923_RS00630	COG1295	ribonuclease BN
DX923_RS00690	COG1131	(ABC) transporter
DX923_RS00760	COG0488	(ABC) transporter
DX923_RS00780	COG1199	ATP-dependent helicase activity
DX923_RS00780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DX923_RS00785	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DX923_RS00815	COG1132	(ABC) transporter
DX923_RS00820	COG0110	maltose O-acetyltransferase activity
DX923_RS00825	COG1132	(ABC) transporter
DX923_RS00840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DX923_RS00845	COG0628	permease
DX923_RS00855	COG1122	ATPase activity
DX923_RS00865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DX923_RS00870	COG0601	transmembrane transport
DX923_RS00945	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DX923_RS00950	COG2188	Transcriptional regulator
DX923_RS00955	COG0747	negative chemotaxis
DX923_RS00965	COG0444	Belongs to the ABC transporter superfamily
DX923_RS00970	COG4608	Belongs to the ABC transporter superfamily
DX923_RS00975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DX923_RS00980	COG1940	carbohydrate kinase activity
DX923_RS01000	COG1863	multisubunit Na H antiporter MnhE subunit
DX923_RS01005	COG0651	ATP synthesis coupled electron transport
DX923_RS01010	COG1006	Multisubunit Na H antiporter MnhC subunit
DX923_RS01015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DX923_RS01015	COG2111	Na H antiporter
DX923_RS01045	COG1140	nitrate reductase beta subunit
DX923_RS01075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DX923_RS01095	COG0671	phosphoesterase, PA-phosphatase related
DX923_RS01100	COG2259	Doxx family
DX923_RS01105	COG3973	AAA domain
DX923_RS01120	COG0366	Alpha amylase catalytic
DX923_RS01130	COG2182	Extracellular solute-binding protein
DX923_RS01155	COG2226	methyltransferase
DX923_RS01160	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DX923_RS01185	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DX923_RS01185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DX923_RS01205	COG2814	Major facilitator Superfamily
DX923_RS01225	COG0577	efflux transmembrane transporter activity
DX923_RS01230	COG1136	(ABC) transporter
DX923_RS01230	COG0577	efflux transmembrane transporter activity
DX923_RS01235	COG2197	response regulator
DX923_RS01240	COG4585	Histidine kinase
DX923_RS01245	COG2197	response regulator
DX923_RS01250	COG3850	Histidine kinase
DX923_RS01275	COG1012	belongs to the aldehyde dehydrogenase family
DX923_RS01285	COG0500	methyltransferase
DX923_RS01290	COG1024	Enoyl-CoA hydratase
DX923_RS01310	COG1151	hydroxylamine reductase activity
DX923_RS01325	COG0671	phosphoesterase, PA-phosphatase related
DX923_RS01330	COG1803	Methylglyoxal synthase
DX923_RS01330	COG1597	lipid kinase activity
DX923_RS01350	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DX923_RS01365	COG0561	phosphatase activity
DX923_RS01375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DX923_RS01420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DX923_RS01435	COG5265	(ABC) transporter
DX923_RS01440	COG4988	ABC transporter
DX923_RS01445	COG1294	oxidase, subunit
DX923_RS01450	COG1271	oxidase subunit
DX923_RS01455	COG2813	Specifically methylates the guanine in position
DX923_RS01460	COG1716	ATPase activity
DX923_RS01490	COG0464	growth
DX923_RS01530	COG2233	PERMEase
DX923_RS01540	COG0517	IMP dehydrogenase activity
DX923_RS01540	COG1125	glycine betaine transport
DX923_RS01555	COG2197	response regulator
DX923_RS01565	COG2409	Drug exporters of the RND superfamily
DX923_RS01580	COG1115	amino acid carrier protein
DX923_RS01595	COG1869	D-ribose catabolic process
DX923_RS01600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DX923_RS01610	COG1172	Belongs to the binding-protein-dependent transport system permease family
DX923_RS01615	COG1129	ABC transporter
DX923_RS01620	COG1609	Transcriptional regulator
DX923_RS01645	COG3052	prosthetic group binding
DX923_RS01650	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
DX923_RS01655	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DX923_RS01660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DX923_RS01690	COG3265	gluconokinase activity
DX923_RS01695	COG2186	Transcriptional regulator
DX923_RS01705	COG5002	protein histidine kinase activity
DX923_RS01720	COG0204	Acyl-transferase
DX923_RS01720	COG0318	PFAM AMP-dependent synthetase and ligase
DX923_RS01725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DX923_RS01750	COG1131	(ABC) transporter
DX923_RS01775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DX923_RS01780	COG1028	Short-chain dehydrogenase reductase Sdr
DX923_RS01785	COG1028	Short-chain dehydrogenase reductase Sdr
DX923_RS01805	COG0300	oxidoreductase activity
DX923_RS01810	COG1024	Enoyl-CoA hydratase
DX923_RS01820	COG1024	Enoyl-CoA hydratase
DX923_RS01825	COG0596	Alpha beta hydrolase
DX923_RS01845	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DX923_RS01850	COG1492	cobalamin metabolic process
DX923_RS01880	COG1404	Belongs to the peptidase S8 family
DX923_RS01925	COG0310	cobalt ion transport
DX923_RS01930	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
DX923_RS01945	COG1797	cobyrinic acid a,c-diamide synthase activity
DX923_RS01955	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DX923_RS01970	COG1132	(ABC) transporter
DX923_RS01975	COG4988	ABC transporter
DX923_RS02005	COG0405	Gamma-glutamyltransferase
DX923_RS02025	COG1131	(ABC) transporter
DX923_RS02040	COG1131	(ABC) transporter
DX923_RS02070	COG1408	metallophosphoesterase
DX923_RS02085	COG0003	Pfam Anion-transporting ATPase
DX923_RS02130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DX923_RS02140	COG0205	6-phosphofructokinase activity
DX923_RS02145	COG1028	Short-chain dehydrogenase reductase Sdr
DX923_RS02145	COG0604	alcohol dehydrogenase
DX923_RS02145	COG3321	synthase
DX923_RS02150	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DX923_RS02155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DX923_RS02165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DX923_RS02175	COG3279	Response regulator of the LytR AlgR family
DX923_RS02180	COG3275	phosphorelay sensor kinase activity
DX923_RS02215	COG2375	cellular response to nickel ion
DX923_RS02215	COG1132	(ABC) transporter
DX923_RS02250	COG1205	dead DEAH box helicase
DX923_RS02250	COG1111	helicase
DX923_RS02255	COG1366	Belongs to the anti-sigma-factor antagonist family
DX923_RS02270	COG1754	DNA topoisomerase type I activity
DX923_RS02270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DX923_RS02280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DX923_RS02285	COG0470	DNA polymerase III
DX923_RS02335	COG0386	Belongs to the glutathione peroxidase family
DX923_RS02345	COG1120	ATPase activity
DX923_RS02350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS02360	COG0662	Cupin 2, conserved barrel domain protein
DX923_RS02415	COG0395	ABC-type sugar transport system, permease component
DX923_RS02430	COG1609	Transcriptional regulator
DX923_RS02440	COG0791	NLP P60 protein
DX923_RS02445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DX923_RS02450	COG2027	D-alanyl-D-alanine carboxypeptidase
DX923_RS02460	COG0037	tRNA processing
DX923_RS02470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DX923_RS02480	COG0302	gtp cyclohydrolase
DX923_RS02485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DX923_RS02490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DX923_RS02500	COG0649	NAD binding
DX923_RS02540	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DX923_RS02545	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DX923_RS02565	COG1940	carbohydrate kinase activity
DX923_RS02570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DX923_RS02575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DX923_RS02580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DX923_RS02585	COG2897	thiosulfate sulfurtransferase activity
DX923_RS02600	COG2226	methyltransferase
DX923_RS02615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DX923_RS02620	COG1121	(ABC) transporter
DX923_RS02625	COG3443	Belongs to the bacterial solute-binding protein 9 family
DX923_RS02625	COG0803	Belongs to the bacterial solute-binding protein 9 family
DX923_RS02630	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DX923_RS02645	COG1136	(ABC) transporter
DX923_RS02645	COG0577	efflux transmembrane transporter activity
DX923_RS02660	COG1131	(ABC) transporter
DX923_RS02680	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DX923_RS02685	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DX923_RS02695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DX923_RS02705	COG0523	cobalamin synthesis protein
DX923_RS02710	COG0248	Ppx GppA phosphatase
DX923_RS02715	COG1082	Xylose isomerase domain protein TIM barrel
DX923_RS02720	COG0506	proline dehydrogenase activity
DX923_RS02725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DX923_RS02735	COG0123	including yeast histone deacetylase and acetoin utilization protein
DX923_RS02760	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DX923_RS02765	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DX923_RS02770	COG0181	hydroxymethylbilane synthase activity
DX923_RS02780	COG0113	porphobilinogen synthase activity
DX923_RS02795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DX923_RS02800	COG0406	alpha-ribazole phosphatase activity
DX923_RS02810	COG0785	Cytochrome C biogenesis protein
DX923_RS02820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DX923_RS02830	COG1929	Belongs to the glycerate kinase type-1 family
DX923_RS02860	COG0857	belongs to the CobB CobQ family
DX923_RS02860	COG0280	phosphate acetyltransferase
DX923_RS02865	COG4948	Mandelate Racemase Muconate Lactonizing
DX923_RS02870	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DX923_RS02875	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DX923_RS02885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DX923_RS02890	COG0459	protein refolding
DX923_RS02900	COG1595	DNA-templated transcription, initiation
DX923_RS02915	COG0516	GMP reductase activity
DX923_RS02920	COG1012	belongs to the aldehyde dehydrogenase family
DX923_RS02940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DX923_RS02950	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DX923_RS02950	COG0519	Catalyzes the synthesis of GMP from XMP
DX923_RS02975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DX923_RS02980	COG0535	radical SAM domain protein
DX923_RS03000	COG1492	cobalamin metabolic process
DX923_RS03010	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DX923_RS03020	COG0494	nUDIX hydrolase
DX923_RS03035	COG1129	ABC transporter
DX923_RS03040	COG1172	Belongs to the binding-protein-dependent transport system permease family
DX923_RS03045	COG1172	Belongs to the binding-protein-dependent transport system permease family
DX923_RS03050	COG1070	Carbohydrate kinase
DX923_RS03065	COG0739	heme binding
DX923_RS03070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DX923_RS03080	COG0254	rRNA binding
DX923_RS03085	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DX923_RS03090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DX923_RS03100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DX923_RS03110	COG0045	succinate-CoA ligase (ADP-forming) activity
DX923_RS03120	COG1301	dicarboxylic acid transport
DX923_RS03125	COG0726	polysaccharide deacetylase
DX923_RS03130	COG1216	Glycosyl transferase, family 2
DX923_RS03190	COG1595	DNA-templated transcription, initiation
DX923_RS03210	COG0138	bifunctional purine biosynthesis protein purh
DX923_RS03215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DX923_RS03235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS03240	COG1120	ATPase activity
DX923_RS03250	COG0039	L-malate dehydrogenase activity
DX923_RS03280	COG1686	Belongs to the peptidase S11 family
DX923_RS03290	COG1744	ABC transporter substrate-binding protein PnrA-like
DX923_RS03295	COG3845	ABC transporter
DX923_RS03300	COG4603	Belongs to the binding-protein-dependent transport system permease family
DX923_RS03305	COG1079	Belongs to the binding-protein-dependent transport system permease family
DX923_RS03315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DX923_RS03345	COG0714	Associated with various cellular activities
DX923_RS03370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DX923_RS03390	COG4770	biotin carboxylase activity
DX923_RS03395	COG0656	L-ascorbic acid biosynthetic process
DX923_RS03430	COG1960	acyl-CoA dehydrogenase activity
DX923_RS03435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DX923_RS03440	COG0424	maF-like protein
DX923_RS03455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DX923_RS03470	COG1024	Enoyl-CoA hydratase
DX923_RS03475	COG0745	RESPONSE REGULATOR receiver
DX923_RS03495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DX923_RS03515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DX923_RS03520	COG2119	membrane
DX923_RS03540	COG1086	Polysaccharide biosynthesis protein
DX923_RS03545	COG1086	Polysaccharide biosynthesis protein
DX923_RS03565	COG0567	Dehydrogenase, E1 component
DX923_RS03565	COG0508	dehydrogenase complex catalyzes the overall conversion of
DX923_RS03565	COG0508	dehydrogenase complex catalyzes the overall conversion of
DX923_RS03565	COG0567	Dehydrogenase, E1 component
DX923_RS03570	COG1253	flavin adenine dinucleotide binding
DX923_RS03580	COG2390	Transcriptional regulator
DX923_RS03585	COG1735	metal-dependent hydrolase with the TIM-barrel fold
DX923_RS03605	COG2814	Major facilitator Superfamily
DX923_RS03620	COG0018	arginyl-trna synthetase
DX923_RS03625	COG0019	diaminopimelate decarboxylase activity
DX923_RS03630	COG0460	homoserine dehydrogenase
DX923_RS03635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DX923_RS03640	COG0083	homoserine kinase activity
DX923_RS03650	COG0254	rRNA binding
DX923_RS03655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DX923_RS03660	COG2890	protein-(glutamine-N5) methyltransferase activity
DX923_RS03675	COG0009	L-threonylcarbamoyladenylate synthase
DX923_RS03680	COG2186	Transcriptional regulator
DX923_RS03685	COG1620	l-lactate permease
DX923_RS03690	COG0247	lactate metabolic process
DX923_RS03695	COG1139	Iron-sulfur cluster binding protein
DX923_RS03700	COG1556	Lactate utilization protein
DX923_RS03705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DX923_RS03720	COG0356	it plays a direct role in the translocation of protons across the membrane
DX923_RS03725	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DX923_RS03730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DX923_RS03735	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DX923_RS03740	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DX923_RS03745	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DX923_RS03750	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DX923_RS03755	COG1045	serine acetyltransferase
DX923_RS03775	COG0438	transferase activity, transferring glycosyl groups
DX923_RS03785	COG0110	maltose O-acetyltransferase activity
DX923_RS03810	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DX923_RS03825	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DX923_RS03825	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DX923_RS03830	COG1215	transferase activity, transferring glycosyl groups
DX923_RS03835	COG0463	Glycosyl transferase, family 2
DX923_RS03840	COG0405	Gamma-glutamyltransferase
DX923_RS03845	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DX923_RS03850	COG1250	3-hydroxyacyl-CoA dehydrogenase
DX923_RS03875	COG1438	arginine binding
DX923_RS03885	COG0549	Belongs to the carbamate kinase family
DX923_RS03890	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DX923_RS03895	COG2235	arginine
DX923_RS03900	COG0183	Belongs to the thiolase family
DX923_RS03960	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DX923_RS03970	COG0579	oxidoreductase
DX923_RS03985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DX923_RS03990	COG0366	Alpha amylase catalytic
DX923_RS03995	COG0366	Alpha amylase catalytic
DX923_RS04035	COG0058	SHG alpha-glucan phosphorylase activity
DX923_RS04055	COG0110	maltose O-acetyltransferase activity
DX923_RS04065	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DX923_RS04075	COG0482	sulfurtransferase activity
DX923_RS04080	COG0402	S-adenosylhomocysteine deaminase activity
DX923_RS04095	COG0367	asparagine synthase
DX923_RS04100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DX923_RS04110	COG5650	phosphatidylinositol metabolic process
DX923_RS04115	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DX923_RS04120	COG0154	amidase activity
DX923_RS04125	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DX923_RS04140	COG0129	dihydroxy-acid dehydratase activity
DX923_RS04145	COG2193	ferroxidase activity
DX923_RS04165	COG0440	acetolactate synthase activity
DX923_RS04170	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DX923_RS04180	COG1472	Belongs to the glycosyl hydrolase 3 family
DX923_RS04190	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DX923_RS04210	COG0714	Associated with various cellular activities
DX923_RS04230	COG0473	3-isopropylmalate dehydrogenase activity
DX923_RS04235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DX923_RS04250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DX923_RS04260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DX923_RS04270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DX923_RS04295	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DX923_RS04295	COG3608	succinylglutamate desuccinylase aspartoacylase
DX923_RS04300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DX923_RS04305	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DX923_RS04305	COG3608	succinylglutamate desuccinylase aspartoacylase
DX923_RS04310	COG1414	Transcriptional regulator
DX923_RS04320	COG0066	3-isopropylmalate dehydratase activity
DX923_RS04325	COG0776	regulation of translation
DX923_RS04340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DX923_RS04345	COG0833	amino acid
DX923_RS04350	COG1181	Belongs to the D-alanine--D-alanine ligase family
DX923_RS04370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DX923_RS04375	COG1461	Dihydroxyacetone kinase
DX923_RS04385	COG0742	ribosomal rna small subunit methyltransferase
DX923_RS04395	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DX923_RS04405	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DX923_RS04410	COG0571	ribonuclease III activity
DX923_RS04415	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DX923_RS04420	COG1254	Belongs to the acylphosphatase family
DX923_RS04465	COG4214	carbohydrate transport
DX923_RS04500	COG0228	four-way junction DNA binding
DX923_RS04505	COG1837	Belongs to the UPF0109 family
DX923_RS04510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DX923_RS04515	COG0336	Belongs to the RNA methyltransferase TrmD family
DX923_RS04520	COG0335	large ribosomal subunit rRNA binding
DX923_RS04525	COG0681	Belongs to the peptidase S26 family
DX923_RS04530	COG0681	Belongs to the peptidase S26 family
DX923_RS04535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DX923_RS04545	COG0792	nuclease activity
DX923_RS04560	COG4974	Belongs to the 'phage' integrase family
DX923_RS04580	COG0052	Belongs to the universal ribosomal protein uS2 family
DX923_RS04585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DX923_RS04595	COG0528	UMP kinase activity
DX923_RS04600	COG0233	cytoplasmic translational termination
DX923_RS04605	COG0575	Belongs to the CDS family
DX923_RS04615	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DX923_RS04620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DX923_RS04630	COG0738	Major facilitator superfamily
DX923_RS04635	COG2390	Transcriptional regulator
DX923_RS04650	COG1695	Transcriptional regulator
DX923_RS04665	COG3842	ATPase activity
DX923_RS04670	COG1176	ABC-type spermidine putrescine transport system, permease component I
DX923_RS04675	COG1177	transmembrane transport
DX923_RS04690	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DX923_RS04695	COG0750	zinc metalloprotease
DX923_RS04700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DX923_RS04705	COG0454	-acetyltransferase
DX923_RS04705	COG0456	acetyltransferase
DX923_RS04710	COG0442	prolyl-tRNA aminoacylation
DX923_RS04725	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DX923_RS04735	COG0778	Nitroreductase
DX923_RS04750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DX923_RS04755	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DX923_RS04760	COG2837	iron assimilation
DX923_RS04775	COG0779	Required for maturation of 30S ribosomal subunits
DX923_RS04790	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DX923_RS04790	COG0481	GTPase activity
DX923_RS04795	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DX923_RS04800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DX923_RS04825	COG1530	ribonuclease E activity
DX923_RS04830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DX923_RS04840	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DX923_RS04850	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DX923_RS04855	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DX923_RS04870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DX923_RS04875	COG0799	negative regulation of ribosome biogenesis
DX923_RS04890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DX923_RS04905	COG0714	Associated with various cellular activities
DX923_RS04910	COG2001	Belongs to the MraZ family
DX923_RS04915	COG0275	rRNA processing
DX923_RS04925	COG0768	penicillin binding
DX923_RS04930	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DX923_RS04935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DX923_RS04940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DX923_RS04945	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DX923_RS04955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DX923_RS04960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DX923_RS04970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DX923_RS04975	COG1496	oxidoreductase activity
DX923_RS04985	COG1799	cell septum assembly
DX923_RS05005	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DX923_RS05015	COG0587	DNA-directed DNA polymerase activity
DX923_RS05045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DX923_RS05050	COG0131	Imidazoleglycerol-phosphate dehydratase
DX923_RS05055	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DX923_RS05060	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DX923_RS05075	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DX923_RS05080	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DX923_RS05085	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DX923_RS05090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DX923_RS05095	COG5002	protein histidine kinase activity
DX923_RS05100	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DX923_RS05105	COG0072	phenylalanine-tRNA ligase activity
DX923_RS05105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DX923_RS05110	COG1028	Short-chain dehydrogenase reductase Sdr
DX923_RS05115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DX923_RS05125	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DX923_RS05130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DX923_RS05135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DX923_RS05140	COG1438	arginine binding
DX923_RS05145	COG0165	Argininosuccinate lyase
DX923_RS05150	COG2094	Belongs to the DNA glycosylase MPG family
DX923_RS05165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DX923_RS05200	COG0647	UMP catabolic process
DX923_RS05215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DX923_RS05220	COG0497	DNA recombination
DX923_RS05225	COG0504	CTP synthase activity
DX923_RS05230	COG0494	nUDIX hydrolase
DX923_RS05235	COG3012	SEC-C Motif Domain Protein
DX923_RS05240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DX923_RS05250	COG2409	Drug exporters of the RND superfamily
DX923_RS05260	COG4608	Belongs to the ABC transporter superfamily
DX923_RS05270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DX923_RS05275	COG0601	transmembrane transport
DX923_RS05285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DX923_RS05290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DX923_RS05300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DX923_RS05305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DX923_RS05310	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DX923_RS05315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DX923_RS05320	COG2197	response regulator
DX923_RS05335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DX923_RS05340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DX923_RS05350	COG0166	Belongs to the GPI family
DX923_RS05355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DX923_RS05365	COG1131	(ABC) transporter
DX923_RS05380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DX923_RS05385	COG0540	Belongs to the ATCase OTCase family
DX923_RS05390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DX923_RS05395	COG0505	Belongs to the CarA family
DX923_RS05400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DX923_RS05405	COG0543	2 iron, 2 sulfur cluster binding
DX923_RS05410	COG0167	dihydroorotate dehydrogenase activity
DX923_RS05415	COG0284	orotidine-5'-phosphate decarboxylase activity
DX923_RS05420	COG1605	Chorismate mutase
DX923_RS05420	COG0287	Prephenate dehydrogenase
DX923_RS05430	COG0194	GDP metabolic process
DX923_RS05435	COG1758	RNA polymerase activity
DX923_RS05445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DX923_RS05455	COG2814	Major facilitator Superfamily
DX923_RS05460	COG0242	peptide deformylase activity
DX923_RS05465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DX923_RS05475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DX923_RS05485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DX923_RS05500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DX923_RS05500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DX923_RS05505	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DX923_RS05515	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DX923_RS05520	COG0140	phosphoribosyl-ATP diphosphatase activity
DX923_RS05525	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DX923_RS05535	COG4129	membrane
DX923_RS05545	COG0180	Tryptophanyl-tRNA synthetase
DX923_RS05550	COG0107	imidazoleglycerol-phosphate synthase activity
DX923_RS05580	COG1929	Belongs to the glycerate kinase type-1 family
DX923_RS05595	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DX923_RS05600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DX923_RS05605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DX923_RS05615	COG1376	ErfK ybiS ycfS ynhG family protein
DX923_RS05630	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DX923_RS05635	COG0723	plastoquinol--plastocyanin reductase activity
DX923_RS05645	COG1845	cytochrome c oxidase, subunit III
DX923_RS05655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DX923_RS05695	COG1940	carbohydrate kinase activity
DX923_RS05710	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DX923_RS05715	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DX923_RS05720	COG0515	serine threonine protein kinase
DX923_RS05720	COG2815	serine threonine protein kinase
DX923_RS05735	COG0142	geranyltranstransferase activity
DX923_RS05750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DX923_RS05780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DX923_RS05785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DX923_RS05790	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DX923_RS05795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DX923_RS05835	COG1435	thymidine kinase activity
DX923_RS05845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DX923_RS05885	COG0569	domain protein
DX923_RS05890	COG0531	amino acid
DX923_RS05895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DX923_RS05900	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DX923_RS05925	COG0589	response to stress
DX923_RS05930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DX923_RS05940	COG0481	GTPase activity
DX923_RS05945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DX923_RS05970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DX923_RS05975	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DX923_RS05990	COG1420	regulation of RNA biosynthetic process
DX923_RS05995	COG0484	heat shock protein binding
DX923_RS06000	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DX923_RS06010	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DX923_RS06020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DX923_RS06030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DX923_RS06045	COG1381	Involved in DNA repair and RecF pathway recombination
DX923_RS06050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DX923_RS06060	COG0137	argininosuccinate synthase activity
DX923_RS06075	COG1132	(ABC) transporter
DX923_RS06100	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DX923_RS06105	COG0358	DNA primase activity
DX923_RS06145	COG1263	PTS System
DX923_RS06145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DX923_RS06145	COG2190	(PTS) system
DX923_RS06160	COG2233	PERMEase
DX923_RS06165	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DX923_RS06165	COG0493	'glutamate synthase
DX923_RS06170	COG0402	S-adenosylhomocysteine deaminase activity
DX923_RS06175	COG1131	(ABC) transporter
DX923_RS06210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DX923_RS06215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DX923_RS06230	COG0674	pyruvate-flavodoxin oxidoreductase activity
DX923_RS06230	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DX923_RS06230	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DX923_RS06230	COG1013	pyruvate-flavodoxin oxidoreductase activity
DX923_RS06235	COG2226	methyltransferase
DX923_RS06240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DX923_RS06260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DX923_RS06265	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DX923_RS06275	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DX923_RS06280	COG0217	transcriptional regulatory protein
DX923_RS06285	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DX923_RS06290	COG0632	four-way junction helicase activity
DX923_RS06295	COG2255	four-way junction helicase activity
DX923_RS06300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DX923_RS06305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DX923_RS06310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DX923_RS06315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DX923_RS06320	COG1196	nuclear chromosome segregation
DX923_RS06330	COG0124	histidyl-tRNA synthetase
DX923_RS06345	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DX923_RS06350	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DX923_RS06365	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DX923_RS06370	COG1160	GTP binding
DX923_RS06400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS06405	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS06410	COG1120	ATPase activity
DX923_RS06415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DX923_RS06420	COG1132	(ABC) transporter
DX923_RS06430	COG1132	(ABC) transporter
DX923_RS06435	COG2382	esterase
DX923_RS06460	COG1716	ATPase activity
DX923_RS06475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DX923_RS06475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DX923_RS06490	COG0205	6-phosphofructokinase activity
DX923_RS06500	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DX923_RS06515	COG3256	nitric oxide reductase
DX923_RS06540	COG5012	cobalamin binding
DX923_RS06550	COG3457	Alanine racemase
DX923_RS06555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DX923_RS06565	COG1136	(ABC) transporter
DX923_RS06565	COG0577	efflux transmembrane transporter activity
DX923_RS06580	COG0428	transporter
DX923_RS06590	COG0488	(ABC) transporter
DX923_RS06595	COG1024	Enoyl-CoA hydratase
DX923_RS06615	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DX923_RS06620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DX923_RS06630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DX923_RS06640	COG1028	Short-chain dehydrogenase reductase Sdr
DX923_RS06645	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DX923_RS06655	COG0560	Phosphoserine phosphatase
DX923_RS06655	COG3830	Belongs to the UPF0237 family
DX923_RS06665	COG0297	glycogen (starch) synthase activity
DX923_RS06670	COG1119	ATPase activity
DX923_RS06690	COG1881	PFAM PEBP family protein
DX923_RS06705	COG0204	Acyl-transferase
DX923_RS06755	COG0395	ABC-type sugar transport system, permease component
DX923_RS06790	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DX923_RS06795	COG0629	single-stranded DNA binding
DX923_RS06805	COG1946	Acyl-CoA thioesterase
DX923_RS06810	COG0477	Major facilitator Superfamily
DX923_RS06815	COG0668	transmembrane transport
DX923_RS06835	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DX923_RS06855	COG2409	Drug exporters of the RND superfamily
DX923_RS06860	COG0363	glucosamine-6-phosphate deaminase activity
DX923_RS06875	COG0544	peptidyl-prolyl cis-trans isomerase activity
DX923_RS06880	COG0740	serine-type endopeptidase activity
DX923_RS06885	COG0740	serine-type endopeptidase activity
DX923_RS06890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DX923_RS06940	COG0277	FAD linked oxidase domain protein
DX923_RS06945	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DX923_RS06955	COG0285	dihydrofolate synthase activity
DX923_RS06965	COG0105	UTP biosynthetic process
DX923_RS06970	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DX923_RS06975	COG1185	polyribonucleotide nucleotidyltransferase activity
DX923_RS06980	COG1132	(ABC) transporter
DX923_RS07010	COG0167	dihydroorotate dehydrogenase activity
DX923_RS07015	COG0674	pyruvate-flavodoxin oxidoreductase activity
DX923_RS07015	COG1013	pyruvate-flavodoxin oxidoreductase activity
DX923_RS07015	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DX923_RS07015	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DX923_RS07030	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DX923_RS07040	COG1966	Carbon starvation protein
DX923_RS07055	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DX923_RS07060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DX923_RS07065	COG1674	ftsk spoiiie
DX923_RS07070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DX923_RS07080	COG1058	Belongs to the CinA family
DX923_RS07080	COG1546	Belongs to the CinA family
DX923_RS07105	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DX923_RS07110	COG2137	regulation of response to DNA damage stimulus
DX923_RS07115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DX923_RS07120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DX923_RS07125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DX923_RS07130	COG2813	Specifically methylates the guanine in position
DX923_RS07135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DX923_RS07150	COG0268	Binds directly to 16S ribosomal RNA
DX923_RS07160	COG0495	leucyl-tRNA aminoacylation
DX923_RS07165	COG1307	EDD domain protein, DegV family
DX923_RS07170	COG0322	excinuclease ABC activity
DX923_RS07175	COG0658	competence protein
DX923_RS07175	COG2333	competence protein COMEC
DX923_RS07180	COG0583	DNA-binding transcription factor activity
DX923_RS07185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DX923_RS07205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DX923_RS07210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DX923_RS07225	COG2733	membrane
DX923_RS07230	COG1022	Amp-dependent synthetase and ligase
DX923_RS07235	COG0747	negative chemotaxis
DX923_RS07245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DX923_RS07250	COG4172	Belongs to the ABC transporter superfamily
DX923_RS07260	COG2873	o-acetylhomoserine
DX923_RS07265	COG1022	Amp-dependent synthetase and ligase
DX923_RS07270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DX923_RS07280	COG1643	Atp-dependent helicase
DX923_RS07300	COG1024	Enoyl-CoA hydratase
DX923_RS07300	COG1250	3-hydroxyacyl-CoA dehydrogenase
DX923_RS07305	COG0183	Belongs to the thiolase family
DX923_RS07320	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DX923_RS07325	COG3253	May function as heme-dependent peroxidase
DX923_RS07335	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DX923_RS07375	COG0697	spore germination
DX923_RS07405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DX923_RS07410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DX923_RS07425	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DX923_RS07450	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DX923_RS07465	COG3022	response to hydroperoxide
DX923_RS07485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DX923_RS07510	COG0174	glutamine synthetase
DX923_RS07515	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DX923_RS07560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DX923_RS07565	COG0321	lipoyl(octanoyl) transferase activity
DX923_RS07575	COG0508	dehydrogenase complex catalyzes the overall conversion of
DX923_RS07580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DX923_RS07585	COG2755	lipolytic protein G-D-S-L family
DX923_RS07585	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DX923_RS07590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DX923_RS07595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DX923_RS07635	COG0134	indole-3-glycerol-phosphate synthase activity
DX923_RS07640	COG0133	tryptophan synthase activity
DX923_RS07645	COG0159	tryptophan synthase activity
DX923_RS07665	COG0070	glutamate synthase
DX923_RS07665	COG0069	glutamate synthase activity
DX923_RS07665	COG0067	glutamate synthase
DX923_RS07675	COG0469	pyruvate kinase activity
DX923_RS07705	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DX923_RS07710	COG2226	methyltransferase
DX923_RS07725	COG0237	dephospho-CoA kinase activity
DX923_RS07725	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DX923_RS07745	COG0556	nucleotide-excision repair
DX923_RS07755	COG1960	acyl-CoA dehydrogenase activity
DX923_RS07775	COG0318	PFAM AMP-dependent synthetase and ligase
DX923_RS07800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DX923_RS07810	COG0322	excinuclease ABC activity
DX923_RS07815	COG1660	Displays ATPase and GTPase activities
DX923_RS07820	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DX923_RS07825	COG1481	regulation of sporulation
DX923_RS07835	COG0126	phosphoglycerate kinase activity
DX923_RS07840	COG0149	triose-phosphate isomerase activity
DX923_RS07845	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DX923_RS07865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DX923_RS07875	COG0109	protoheme IX farnesyltransferase activity
DX923_RS07895	COG1131	(ABC) transporter
DX923_RS07910	COG0719	Fe-S assembly protein
DX923_RS07920	COG0396	ATPase activity
DX923_RS07935	COG2151	metal-sulfur cluster biosynthetic enzyme
DX923_RS07960	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DX923_RS07965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DX923_RS07970	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DX923_RS07990	COG3958	Transketolase
DX923_RS07995	COG3959	Transketolase, thiamine diphosphate binding domain
DX923_RS08005	COG1051	belongs to the nudix hydrolase family
DX923_RS08025	COG1216	Glycosyl transferase, family 2
DX923_RS08035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DX923_RS08045	COG0805	protein transport
DX923_RS08050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DX923_RS08075	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DX923_RS08080	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DX923_RS08085	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DX923_RS08095	COG4122	O-methyltransferase activity
DX923_RS08100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DX923_RS08110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DX923_RS08125	COG1222	aaa ATPase
DX923_RS08135	COG1994	Peptidase M50
DX923_RS08135	COG0517	IMP dehydrogenase activity
DX923_RS08150	COG0646	methionine synthase
DX923_RS08150	COG1410	methionine synthase
DX923_RS08160	COG0215	cysteine-tRNA ligase activity
DX923_RS08175	COG0588	phosphoglycerate mutase activity
DX923_RS08180	COG0598	Magnesium transport protein CorA
DX923_RS08185	COG1968	undecaprenyl-diphosphatase activity
DX923_RS08205	COG0754	glutathionylspermidine amidase activity
DX923_RS08210	COG3766	membrane
DX923_RS08225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DX923_RS08230	COG0488	(ABC) transporter
DX923_RS08250	COG3226	Transcriptional regulator
DX923_RS08265	COG1131	(ABC) transporter
DX923_RS08290	COG1063	alcohol dehydrogenase
DX923_RS08295	COG0156	8-amino-7-oxononanoate synthase activity
DX923_RS08300	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DX923_RS08320	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DX923_RS08325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DX923_RS08330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DX923_RS08340	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DX923_RS08350	COG1335	isochorismatase
DX923_RS08355	COG0427	acetyl-CoA hydrolase
DX923_RS08360	COG2755	lipolytic protein G-D-S-L family
DX923_RS08360	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DX923_RS08385	COG1678	Uncharacterized ACR, COG1678
DX923_RS08390	COG0513	Belongs to the DEAD box helicase family
DX923_RS08400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DX923_RS08415	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DX923_RS08420	COG0739	heme binding
DX923_RS08420	COG1196	nuclear chromosome segregation
DX923_RS08420	COG0741	lytic transglycosylase activity
DX923_RS08425	COG2177	Part of the ABC transporter FtsEX involved in
DX923_RS08430	COG2884	Cell division ATP-binding protein ftsE
DX923_RS08460	COG4948	Mandelate Racemase Muconate Lactonizing
DX923_RS08465	COG0395	ABC-type sugar transport system, permease component
DX923_RS08470	COG1175	transmembrane transport
DX923_RS08475	COG1653	transport
DX923_RS08480	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DX923_RS08485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DX923_RS08535	COG1357	PFAM Pentapeptide repeats (8 copies)
DX923_RS08545	COG2070	2-Nitropropane dioxygenase
DX923_RS08550	COG1674	ftsk spoiiie
DX923_RS08570	COG2902	Dehydrogenase
DX923_RS08625	COG0653	protein targeting
DX923_RS08640	COG2197	response regulator
DX923_RS08645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DX923_RS08660	COG5002	protein histidine kinase activity
DX923_RS08665	COG0745	RESPONSE REGULATOR receiver
DX923_RS08670	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DX923_RS08675	COG2354	Protein conserved in bacteria
DX923_RS08720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DX923_RS08740	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DX923_RS08765	COG2385	sporulation resulting in formation of a cellular spore
DX923_RS08765	COG2247	cell wall binding repeat
DX923_RS08785	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DX923_RS08790	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DX923_RS08810	COG1595	DNA-templated transcription, initiation
DX923_RS08820	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DX923_RS08825	COG1162	GTPase activity
DX923_RS08830	COG2326	polyphosphate kinase activity
DX923_RS08840	COG0483	inositol monophosphate 1-phosphatase activity
DX923_RS08855	COG0612	Peptidase, M16
DX923_RS08860	COG1252	NADH dehydrogenase
DX923_RS08875	COG1131	(ABC) transporter
DX923_RS08890	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DX923_RS08890	COG3976	FMN-binding domain protein
DX923_RS08895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DX923_RS08895	COG1017	nitric oxide dioxygenase activity
DX923_RS08915	COG1615	UPF0182 protein
DX923_RS08925	COG3480	Lon protease (S16) C-terminal proteolytic domain
DX923_RS08955	COG1120	ATPase activity
DX923_RS08960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS09015	COG0210	DNA helicase
DX923_RS09040	COG0513	Belongs to the DEAD box helicase family
DX923_RS09045	COG2095	MarC family integral membrane protein
DX923_RS09050	COG0613	PHP domain protein
DX923_RS09055	COG4106	trans-aconitate 2-methyltransferase activity
DX923_RS09055	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DX923_RS09065	COG2030	dehydratase
DX923_RS09105	COG3118	belongs to the thioredoxin family
DX923_RS09120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DX923_RS09130	COG0006	proline dipeptidase activity
DX923_RS09140	COG0577	efflux transmembrane transporter activity
DX923_RS09140	COG1136	(ABC) transporter
DX923_RS09190	COG2301	Belongs to the HpcH HpaI aldolase family
DX923_RS09195	COG2239	Acts as a magnesium transporter
DX923_RS09210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DX923_RS09215	COG1595	DNA-templated transcription, initiation
DX923_RS09220	COG4122	O-methyltransferase activity
DX923_RS09230	COG1024	Enoyl-CoA hydratase
DX923_RS09245	COG1611	Belongs to the LOG family
DX923_RS09250	COG0583	DNA-binding transcription factor activity
DX923_RS09265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DX923_RS09300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DX923_RS09305	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DX923_RS09310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DX923_RS09320	COG1131	(ABC) transporter
DX923_RS09330	COG4585	Histidine kinase
DX923_RS09335	COG2197	response regulator
DX923_RS09345	COG2011	ABC-type metal ion transport system permease component
DX923_RS09350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DX923_RS09355	COG1464	Belongs to the NlpA lipoprotein family
DX923_RS09360	COG3835	regulator
DX923_RS09365	COG1028	Short-chain dehydrogenase reductase Sdr
DX923_RS09370	COG0183	Belongs to the thiolase family
DX923_RS09380	COG2610	gluconate transmembrane transporter activity
DX923_RS09385	COG0183	Belongs to the thiolase family
DX923_RS09400	COG1217	gtp-binding protein TYPA
DX923_RS09410	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DX923_RS09420	COG0517	IMP dehydrogenase activity
DX923_RS09435	COG0505	Belongs to the CarA family
DX923_RS09455	COG0596	Alpha beta hydrolase
DX923_RS09460	COG0477	Major facilitator Superfamily
DX923_RS09475	COG0514	ATP-dependent DNA helicase (RecQ)
DX923_RS09505	COG0012	GTP binding
DX923_RS09510	COG1322	Protein conserved in bacteria
DX923_RS09525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DX923_RS09530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DX923_RS09540	COG1215	transferase activity, transferring glycosyl groups
DX923_RS09545	COG0438	transferase activity, transferring glycosyl groups
DX923_RS09550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DX923_RS09555	COG1570	exodeoxyribonuclease VII activity
DX923_RS09560	COG1722	exodeoxyribonuclease VII activity
DX923_RS09590	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DX923_RS09590	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DX923_RS09600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DX923_RS09605	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DX923_RS09610	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DX923_RS09625	COG0101	tRNA pseudouridine synthase activity
DX923_RS09630	COG0203	ribosomal protein L17
DX923_RS09635	COG0202	RNA polymerase activity
DX923_RS09645	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DX923_RS09650	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DX923_RS09655	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DX923_RS09660	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DX923_RS09670	COG0563	adenylate kinase activity
DX923_RS09680	COG0200	Binds to the 23S rRNA
DX923_RS09685	COG1841	ribosomal large subunit assembly
DX923_RS09690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DX923_RS09695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DX923_RS09700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DX923_RS09705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DX923_RS09715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DX923_RS09720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DX923_RS09725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DX923_RS09730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DX923_RS09735	COG0255	Belongs to the universal ribosomal protein uL29 family
DX923_RS09740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DX923_RS09745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DX923_RS09750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DX923_RS09755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DX923_RS09760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DX923_RS09765	COG0089	rRNA binding
DX923_RS09775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DX923_RS09780	COG0051	transcription antitermination factor activity, RNA binding
DX923_RS09785	COG0297	glycogen (starch) synthase activity
DX923_RS09790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DX923_RS09795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DX923_RS09800	COG0049	tRNA binding
DX923_RS09805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DX923_RS09810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DX923_RS09815	COG0085	RNA polymerase activity
DX923_RS09820	COG0222	ribosome binding
DX923_RS09825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DX923_RS09830	COG0081	regulation of translation
DX923_RS09835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DX923_RS09840	COG0250	Participates in transcription elongation, termination and antitermination
DX923_RS09855	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DX923_RS09865	COG2030	dehydratase
DX923_RS09870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DX923_RS09890	COG1122	ATPase activity
DX923_RS09895	COG1268	BioY protein
DX923_RS09900	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DX923_RS09905	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DX923_RS09910	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DX923_RS09920	COG1024	Enoyl-CoA hydratase
DX923_RS09920	COG1250	3-hydroxyacyl-CoA dehydrogenase
DX923_RS09935	COG1666	GTP binding
DX923_RS09940	COG1113	amino acid transport
DX923_RS09945	COG0252	asparaginase activity
DX923_RS09955	COG0501	Belongs to the peptidase M48B family
DX923_RS09960	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DX923_RS09970	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DX923_RS09975	COG0674	pyruvate-flavodoxin oxidoreductase activity
DX923_RS09975	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DX923_RS09980	COG1013	pyruvate-flavodoxin oxidoreductase activity
DX923_RS09985	COG1309	transcriptional regulator
DX923_RS09990	COG0142	geranyltranstransferase activity
DX923_RS10010	COG0713	ATP synthesis coupled electron transport
DX923_RS10015	COG0839	Belongs to the complex I subunit 6 family
DX923_RS10020	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DX923_RS10025	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DX923_RS10030	COG1034	ATP synthesis coupled electron transport
DX923_RS10035	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DX923_RS10045	COG0649	NAD binding
DX923_RS10050	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DX923_RS10055	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DX923_RS10070	COG2226	methyltransferase
DX923_RS10075	COG1169	isochorismate synthase
DX923_RS10080	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DX923_RS10090	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DX923_RS10100	COG0456	acetyltransferase
DX923_RS10100	COG1214	PFAM Peptidase M22, glycoprotease
DX923_RS10105	COG0802	atpase or kinase
DX923_RS10115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DX923_RS10125	COG0736	holo-[acyl-carrier-protein] synthase activity
DX923_RS10130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DX923_RS10135	COG1072	(Pantothenic acid kinase))
DX923_RS10145	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DX923_RS10155	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DX923_RS10165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DX923_RS10175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DX923_RS10180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DX923_RS10190	COG1113	amino acid transport
DX923_RS10225	COG0148	phosphopyruvate hydratase activity
DX923_RS10260	COG0193	aminoacyl-tRNA hydrolase activity
DX923_RS10265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DX923_RS10275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DX923_RS10280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DX923_RS10295	COG1309	transcriptional regulator
DX923_RS10300	COG1846	Transcriptional regulator
DX923_RS10305	COG0488	(ABC) transporter
DX923_RS10310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DX923_RS10315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DX923_RS10320	COG1082	Xylose isomerase domain protein TIM barrel
DX923_RS10325	COG0673	inositol 2-dehydrogenase activity
DX923_RS10330	COG0673	inositol 2-dehydrogenase activity
DX923_RS10335	COG0084	hydrolase, TatD family'
DX923_RS10340	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DX923_RS10350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DX923_RS10355	COG1053	succinate dehydrogenase
DX923_RS10365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DX923_RS10400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DX923_RS10425	COG0521	Mo-molybdopterin cofactor biosynthetic process
DX923_RS10430	COG0315	cyclic pyranopterin monophosphate synthase activity
DX923_RS10440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DX923_RS10460	COG1970	mechanosensitive ion channel activity
DX923_RS10480	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DX923_RS10485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DX923_RS10490	COG2764	glyoxalase bleomycin resistance protein dioxygenase
DX923_RS10505	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DX923_RS10510	COG1126	abc transporter atp-binding protein
DX923_RS10525	COG0010	Belongs to the arginase family
DX923_RS10530	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DX923_RS10535	COG1228	amidohydrolase
DX923_RS10545	COG0318	PFAM AMP-dependent synthetase and ligase
DX923_RS10560	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DX923_RS10565	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DX923_RS10570	COG0791	NLP P60 protein
DX923_RS10570	COG1388	LysM domain
DX923_RS10570	COG3103	Sh3 type 3 domain protein
DX923_RS10600	COG1278	Cold shock
DX923_RS10615	COG3590	peptidase
DX923_RS10630	COG0745	RESPONSE REGULATOR receiver
DX923_RS10635	COG2205	protein histidine kinase activity
DX923_RS10640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DX923_RS10670	COG0459	protein refolding
DX923_RS10680	COG1902	pentaerythritol trinitrate reductase activity
DX923_RS10680	COG0446	pyridine nucleotide-disulphide oxidoreductase
DX923_RS10690	COG1136	(ABC) transporter
DX923_RS10690	COG0577	efflux transmembrane transporter activity
DX923_RS10695	COG1136	(ABC) transporter
DX923_RS10700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DX923_RS10725	COG0709	Synthesizes selenophosphate from selenide and ATP
DX923_RS10760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DX923_RS10760	COG1648	precorrin-2 dehydrogenase activity
DX923_RS10775	COG1846	Transcriptional regulator
DX923_RS10790	COG1175	transmembrane transport
DX923_RS10795	COG3833	ABC-type maltose transport systems, permease component
DX923_RS10800	COG0366	Alpha amylase catalytic
DX923_RS10865	COG1518	maintenance of DNA repeat elements
DX923_RS10880	COG1857	crispr-associated protein
DX923_RS10925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS10950	COG1960	acyl-CoA dehydrogenase activity
DX923_RS11000	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DX923_RS11005	COG3162	membrane
DX923_RS11065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DX923_RS11065	COG0561	phosphatase activity
DX923_RS11075	COG1653	transport
DX923_RS11085	COG3833	ABC-type maltose transport systems, permease component
DX923_RS11090	COG3842	ATPase activity
DX923_RS11110	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DX923_RS11115	COG1116	anion transmembrane transporter activity
DX923_RS11115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DX923_RS11120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DX923_RS11130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DX923_RS11135	COG0215	cysteine-tRNA ligase activity
DX923_RS11150	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DX923_RS11155	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DX923_RS11160	COG1329	Transcriptional regulator
DX923_RS11175	COG5002	protein histidine kinase activity
DX923_RS11185	COG0588	phosphoglycerate mutase activity
DX923_RS11195	COG0438	transferase activity, transferring glycosyl groups
DX923_RS11220	COG1490	D-aminoacyl-tRNA deacylase activity
DX923_RS11230	COG0354	folic acid binding
DX923_RS11235	COG1316	TRANSCRIPTIONal
DX923_RS11240	COG3485	protocatechuate 3,4-dioxygenase
DX923_RS11255	COG0745	RESPONSE REGULATOR receiver
DX923_RS11260	COG4085	toxin activity
DX923_RS11260	COG0737	Belongs to the 5'-nucleotidase family
DX923_RS11260	COG1525	nuclease
DX923_RS11265	COG0456	acetyltransferase
DX923_RS11270	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DX923_RS11285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DX923_RS11355	COG0569	domain protein
DX923_RS11355	COG2985	domain, Protein
DX923_RS11360	COG2808	Putative FMN-binding domain
DX923_RS11380	COG0156	8-amino-7-oxononanoate synthase activity
DX923_RS11385	COG0436	Aminotransferase
DX923_RS11395	COG2851	Citrate transporter
DX923_RS11400	COG0406	alpha-ribazole phosphatase activity
DX923_RS11410	COG1760	l-serine dehydratase
DX923_RS11415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DX923_RS11460	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DX923_RS11465	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DX923_RS11470	COG1684	flagellar biosynthetic protein fliR
DX923_RS11475	COG1987	bacterial-type flagellum assembly
DX923_RS11480	COG1338	Plays a role in the flagellum-specific transport system
DX923_RS11495	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DX923_RS11505	COG1360	Flagellar Motor Protein
DX923_RS11510	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DX923_RS11535	COG0596	Alpha beta hydrolase
DX923_RS11545	COG4786	Flagellar basal body rod
DX923_RS11560	COG0741	lytic transglycosylase activity
DX923_RS11570	COG1157	protein secretion by the type III secretion system
DX923_RS11580	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DX923_RS11585	COG1766	The M ring may be actively involved in energy transduction
DX923_RS11590	COG1677	Flagellar hook-basal body complex protein FliE
DX923_RS11595	COG1558	bacterial-type flagellum-dependent cell motility
DX923_RS11620	COG1136	(ABC) transporter
DX923_RS11635	COG1136	(ABC) transporter
DX923_RS11635	COG4591	ABC-type transport system involved in lipoprotein release permease component
DX923_RS11645	COG2201	protein-glutamate methylesterase activity
DX923_RS11650	COG0745	RESPONSE REGULATOR receiver
DX923_RS11660	COG0643	Histidine kinase
DX923_RS11660	COG0784	Response regulator, receiver
DX923_RS11660	COG2198	Histidine kinase
DX923_RS11670	COG0745	RESPONSE REGULATOR receiver
DX923_RS11695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DX923_RS11700	COG4786	Flagellar basal body rod
DX923_RS11700	COG1256	bacterial-type flagellum assembly
DX923_RS11710	COG1516	flagellar protein fliS
DX923_RS11720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DX923_RS11730	COG0457	Tetratricopeptide repeat
DX923_RS11730	COG0463	Glycosyl transferase, family 2
DX923_RS11745	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DX923_RS11800	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DX923_RS11805	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DX923_RS11820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DX923_RS11850	COG3104	oligopeptide transport
DX923_RS11860	COG0803	Belongs to the bacterial solute-binding protein 9 family
DX923_RS11865	COG1121	(ABC) transporter
DX923_RS11870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DX923_RS11875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DX923_RS11880	COG3291	Pkd domain containing protein
DX923_RS11885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DX923_RS11890	COG0047	phosphoribosylformylglycinamidine synthase activity
DX923_RS11895	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DX923_RS11900	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DX923_RS11905	COG0151	Belongs to the GarS family
DX923_RS11920	COG4139	cobalamin transport
DX923_RS11930	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DX923_RS11935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DX923_RS11950	COG0191	fructose-bisphosphate aldolase activity
DX923_RS11975	COG0586	Pfam SNARE associated Golgi protein
DX923_RS11985	COG0277	FAD linked oxidase domain protein
DX923_RS12000	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DX923_RS12020	COG3387	PFAM Glycoside hydrolase 15-related
DX923_RS12025	COG1012	belongs to the aldehyde dehydrogenase family
DX923_RS12045	COG1113	amino acid transport
DX923_RS12050	COG0542	response to heat
DX923_RS12080	COG1802	Transcriptional regulator
DX923_RS12090	COG0436	Aminotransferase
DX923_RS12100	COG0840	transmembrane signaling receptor activity
DX923_RS12110	COG0789	Transcriptional regulator
DX923_RS12115	COG0484	heat shock protein binding
DX923_RS12120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DX923_RS12125	COG0443	Heat shock 70 kDa protein
DX923_RS12130	COG0789	Transcriptional regulator
DX923_RS12140	COG2816	NAD+ diphosphatase activity
DX923_RS12160	COG2197	response regulator
DX923_RS12165	COG4585	Histidine kinase
DX923_RS12175	COG1136	(ABC) transporter
DX923_RS12185	COG1742	UPF0060 membrane protein
DX923_RS12210	COG2111	Na H antiporter
DX923_RS12210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DX923_RS12215	COG1006	Multisubunit Na H antiporter MnhC subunit
DX923_RS12220	COG0651	ATP synthesis coupled electron transport
DX923_RS12230	COG2212	antiporter activity
DX923_RS12235	COG1320	monovalent cation:proton antiporter activity
DX923_RS12245	COG0697	spore germination
DX923_RS12260	COG1984	allophanate hydrolase subunit 2
DX923_RS12265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DX923_RS12270	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DX923_RS12295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS12300	COG1120	ATPase activity
DX923_RS12305	COG0535	radical SAM domain protein
DX923_RS12320	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
DX923_RS12330	COG4868	Belongs to the UPF0371 family
DX923_RS12350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DX923_RS12355	COG0857	belongs to the CobB CobQ family
DX923_RS12355	COG0280	phosphate acetyltransferase
DX923_RS12365	COG1215	transferase activity, transferring glycosyl groups
DX923_RS12390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DX923_RS12395	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DX923_RS12395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DX923_RS12400	COG0640	Transcriptional regulator
DX923_RS12420	COG3304	Inner membrane component domain
DX923_RS12425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DX923_RS12435	COG1802	Transcriptional regulator
DX923_RS12450	COG0346	lactoylglutathione lyase activity
DX923_RS12490	COG0814	amino acid
DX923_RS12515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DX923_RS12560	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DX923_RS12580	COG2985	domain, Protein
DX923_RS12580	COG0569	domain protein
DX923_RS12605	COG3850	Histidine kinase
DX923_RS12610	COG2197	response regulator
DX923_RS12615	COG3005	denitrification pathway
DX923_RS12620	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
DX923_RS12630	COG0785	Cytochrome C biogenesis protein
DX923_RS12635	COG1333	cytochrome c biogenesis protein
DX923_RS12640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DX923_RS12690	COG2132	Multicopper oxidase
DX923_RS12700	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DX923_RS12710	COG0114	fumarate hydratase activity
DX923_RS12715	COG0698	ribose 5-phosphate isomerase
DX923_RS12745	COG1404	Belongs to the peptidase S8 family
DX923_RS12785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DX923_RS12800	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DX923_RS12805	COG0477	Major facilitator Superfamily
DX923_RS12900	COG0657	acetylesterase activity
DX923_RS12920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DX923_RS12930	COG0477	Major facilitator Superfamily
DX923_RS12955	COG1715	Restriction endonuclease
DX923_RS12975	COG2337	Toxic component of a toxin-antitoxin (TA) module
DX923_RS12995	COG1349	DNA-binding transcription factor activity
DX923_RS13005	COG1882	Formate acetyltransferase
DX923_RS13010	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DX923_RS13035	COG1136	(ABC) transporter
DX923_RS13045	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DX923_RS13050	COG1122	ATPase activity
DX923_RS13055	COG4721	ABC-type cobalt transport system, permease component
DX923_RS13080	COG0508	dehydrogenase complex catalyzes the overall conversion of
DX923_RS13095	COG3340	Belongs to the peptidase S51 family
DX923_RS13105	COG0463	Glycosyl transferase, family 2
DX923_RS13130	COG2986	histidine ammonia-lyase
DX923_RS13145	COG1120	ATPase activity
DX923_RS13185	COG0746	molybdenum cofactor guanylyltransferase activity
DX923_RS13190	COG0604	alcohol dehydrogenase
DX923_RS13190	COG3321	synthase
DX923_RS13190	COG1028	Short-chain dehydrogenase reductase Sdr
DX923_RS13195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS13200	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS13205	COG1120	ATPase activity
DX923_RS13240	COG2364	Membrane
DX923_RS13265	COG2826	transposase and inactivated derivatives, IS30 family
DX923_RS13280	COG1132	(ABC) transporter
DX923_RS13285	COG1132	(ABC) transporter
DX923_RS13300	COG1021	2,3-dihydroxybenzoate-AMP ligase
DX923_RS13320	COG3433	isochorismatase activity
DX923_RS13320	COG1535	isochorismatase
DX923_RS13330	COG2814	Major facilitator Superfamily
DX923_RS13335	COG2197	response regulator
DX923_RS13345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DX923_RS13350	COG0574	Belongs to the PEP-utilizing enzyme family
DX923_RS13350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DX923_RS13365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DX923_RS13375	COG1362	aminopeptidase activity
DX923_RS13430	COG0590	tRNA wobble adenosine to inosine editing
DX923_RS13435	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DX923_RS13460	COG0531	amino acid
DX923_RS13550	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DX923_RS13595	COG0745	RESPONSE REGULATOR receiver
DX923_RS13600	COG2205	protein histidine kinase activity
DX923_RS13615	COG1278	Cold shock
DX923_RS13625	COG1937	Protein conserved in bacteria
DX923_RS13655	COG1045	serine acetyltransferase
DX923_RS13665	COG0247	lactate metabolic process
DX923_RS13665	COG2181	nitrate reductase activity
DX923_RS13690	COG1174	glycine betaine transport
DX923_RS13705	COG0717	Belongs to the dCTP deaminase family
DX923_RS13715	COG0243	molybdopterin cofactor binding
DX923_RS13720	COG0437	4 iron, 4 sulfur cluster binding
DX923_RS13725	COG3302	dmso reductase anchor subunit
DX923_RS13745	COG5002	protein histidine kinase activity
DX923_RS13750	COG4191	Histidine kinase
DX923_RS13770	COG1960	acyl-CoA dehydrogenase activity
DX923_RS13785	COG1404	Belongs to the peptidase S8 family
DX923_RS13790	COG1404	Belongs to the peptidase S8 family
DX923_RS13795	COG1404	Belongs to the peptidase S8 family
DX923_RS13865	COG1674	ftsk spoiiie
DX923_RS13875	COG1404	Belongs to the peptidase S8 family
DX923_RS13915	COG3135	benzoate transporter
DX923_RS13920	COG0508	dehydrogenase complex catalyzes the overall conversion of
DX923_RS13925	COG0022	dehydrogenase e1 component
DX923_RS13945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DX923_RS13965	COG4608	Belongs to the ABC transporter superfamily
DX923_RS13975	COG0752	glycyl-tRNA synthetase alpha subunit
DX923_RS13975	COG0751	glycine-tRNA ligase activity
DX923_RS13980	COG0242	peptide deformylase activity
DX923_RS14010	COG3848	Pyruvate phosphate dikinase
DX923_RS14010	COG0574	Belongs to the PEP-utilizing enzyme family
DX923_RS14060	COG5640	endopeptidase activity
DX923_RS14085	COG3033	Beta-eliminating lyase
DX923_RS14090	COG0738	Major facilitator superfamily
DX923_RS14105	COG0024	Methionine aminopeptidase
DX923_RS14175	COG1131	(ABC) transporter
DX923_RS14195	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DX923_RS14205	COG2949	membrane
DX923_RS14215	COG0745	RESPONSE REGULATOR receiver
DX923_RS14220	COG0473	3-isopropylmalate dehydrogenase activity
DX923_RS14250	COG0247	lactate metabolic process
DX923_RS14250	COG0277	FAD linked oxidase domain protein
DX923_RS14260	COG3268	Saccharopine dehydrogenase
DX923_RS14295	COG0351	phosphomethylpyrimidine kinase
DX923_RS14300	COG1132	(ABC) transporter
DX923_RS14325	COG2184	nucleotidyltransferase activity
DX923_RS14355	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DX923_RS14375	COG1136	(ABC) transporter
DX923_RS14375	COG0577	efflux transmembrane transporter activity
DX923_RS14390	COG1136	(ABC) transporter
DX923_RS14390	COG0577	efflux transmembrane transporter activity
DX923_RS14395	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DX923_RS14405	COG3290	protein histidine kinase activity
DX923_RS14435	COG1605	Chorismate mutase
DX923_RS14435	COG0077	Prephenate dehydratase
DX923_RS14445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DX923_RS14460	COG0009	L-threonylcarbamoyladenylate synthase
DX923_RS14480	COG1937	Protein conserved in bacteria
DX923_RS14495	COG3851	Histidine kinase
DX923_RS14500	COG2197	response regulator
DX923_RS14570	COG0039	L-malate dehydrogenase activity
DX923_RS14575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DX923_RS14580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS14585	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS14590	COG1120	ATPase activity
DX923_RS14600	COG1131	(ABC) transporter
DX923_RS14620	COG1595	DNA-templated transcription, initiation
DX923_RS14630	COG3718	enzyme involved in inositol metabolism
DX923_RS14635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DX923_RS14655	COG2188	Transcriptional regulator
DX923_RS14660	COG3962	Belongs to the TPP enzyme family
DX923_RS14665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DX923_RS14700	COG0697	spore germination
DX923_RS14705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DX923_RS14715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS14720	COG1120	ATPase activity
DX923_RS14740	COG1136	(ABC) transporter
DX923_RS14770	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DX923_RS14775	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DX923_RS14780	COG1472	Belongs to the glycosyl hydrolase 3 family
DX923_RS14785	COG0395	ABC-type sugar transport system, permease component
DX923_RS14790	COG1175	transmembrane transport
DX923_RS14810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DX923_RS14815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DX923_RS14820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DX923_RS14840	COG1250	3-hydroxyacyl-CoA dehydrogenase
DX923_RS14845	COG2030	dehydratase
DX923_RS14845	COG1012	belongs to the aldehyde dehydrogenase family
DX923_RS14865	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DX923_RS14870	COG1846	Transcriptional regulator
DX923_RS14900	COG3396	Phenylacetate-CoA oxygenase
DX923_RS14905	COG3460	Phenylacetate-CoA oxygenase
DX923_RS14910	COG3396	Phenylacetate-CoA oxygenase
DX923_RS14915	COG2151	metal-sulfur cluster biosynthetic enzyme
DX923_RS14920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DX923_RS14925	COG1695	Transcriptional regulator
DX923_RS14945	COG0561	phosphatase activity
DX923_RS14960	COG0154	amidase activity
DX923_RS14995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DX923_RS14995	COG1263	PTS System
DX923_RS15015	COG1126	abc transporter atp-binding protein
DX923_RS15030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DX923_RS15035	COG0583	DNA-binding transcription factor activity
DX923_RS15045	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DX923_RS15055	COG2382	esterase
DX923_RS15060	COG1120	ATPase activity
DX923_RS15065	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS15070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS15075	COG4592	Periplasmic binding protein
DX923_RS15095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DX923_RS15105	COG1012	belongs to the aldehyde dehydrogenase family
DX923_RS15130	COG1957	nucleoside hydrolase
DX923_RS15135	COG1609	Transcriptional regulator
DX923_RS15150	COG0697	spore germination
DX923_RS15160	COG0596	Alpha beta hydrolase
DX923_RS15190	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DX923_RS15195	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DX923_RS15200	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DX923_RS15215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DX923_RS15225	COG0626	cystathionine gamma-synthase activity
DX923_RS15235	COG1301	dicarboxylic acid transport
DX923_RS15245	COG4716	Myosin-crossreactive antigen
DX923_RS15265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DX923_RS15285	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DX923_RS15290	COG1120	ATPase activity
DX923_RS15295	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS15300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS15320	COG1960	acyl-CoA dehydrogenase activity
DX923_RS15325	COG1012	belongs to the aldehyde dehydrogenase family
DX923_RS15330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DX923_RS15335	COG0022	dehydrogenase e1 component
DX923_RS15355	COG2409	Drug exporters of the RND superfamily
DX923_RS15365	COG1950	PFAM Membrane protein of
DX923_RS15375	COG2814	Major facilitator Superfamily
DX923_RS15390	COG1169	isochorismate synthase
DX923_RS15400	COG1028	Short-chain dehydrogenase reductase Sdr
DX923_RS15405	COG0435	Glutathione S-transferase
DX923_RS15435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS15440	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DX923_RS15450	COG1297	OPT oligopeptide transporter protein
DX923_RS15455	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DX923_RS15460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX923_RS15475	COG0477	Major facilitator Superfamily
DX923_RS15480	COG0300	oxidoreductase activity
DX923_RS15485	COG2391	methyltransferase activity
DX923_RS15490	COG0446	pyridine nucleotide-disulphide oxidoreductase
DX923_RS15645	COG0346	lactoylglutathione lyase activity
DX923_RS15665	COG3657	addiction module killer protein
DX923_RS15670	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DX923_RS15695	COG1136	(ABC) transporter
DX923_RS15695	COG0577	efflux transmembrane transporter activity
DX923_RS15705	COG0384	phenazine biosynthesis protein PhzF
DX923_RS15730	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DX923_RS15735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DX923_RS15745	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DX923_RS15765	COG0438	transferase activity, transferring glycosyl groups
DX923_RS15770	COG0297	glycogen (starch) synthase activity
DX923_RS15785	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DX923_RS15785	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DX923_RS15820	COG0359	binds to the 23S rRNA
DX923_RS15825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DX923_RS15835	COG0360	Binds together with S18 to 16S ribosomal RNA
DX923_RS15845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DX923_RS15850	COG1260	myo-inositol-1-phosphate synthase
DX923_RS15855	COG1309	transcriptional regulator
DX923_RS15860	COG1131	(ABC) transporter
DX923_RS15895	COG1595	DNA-templated transcription, initiation
DX923_RS15905	COG0492	ferredoxin-NADP+ reductase activity
DX923_RS15910	COG3118	belongs to the thioredoxin family
DX923_RS15915	COG1051	belongs to the nudix hydrolase family
DX923_RS15925	COG1192	Involved in chromosome partitioning
DX923_RS15930	COG0357	Ribosomal RNA small subunit methyltransferase G
DX923_RS15940	COG0706	membrane insertase activity
DX923_RS15945	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DX923_RS15950	COG0594	ribonuclease P activity
DX923_RS15955	COG0230	Belongs to the bacterial ribosomal protein bL34 family