locus-tag	class	description
HHJ57_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HHJ57_RS00010	COG0592	DNA-directed DNA polymerase activity
HHJ57_RS00020	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HHJ57_RS00025	COG1381	Involved in DNA repair and RecF pathway recombination
HHJ57_RS00030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHJ57_RS00035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HHJ57_RS00040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HHJ57_RS00045	COG0252	asparaginase activity
HHJ57_RS00055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HHJ57_RS00075	COG3133	Outer membrane lipoprotein
HHJ57_RS00080	COG3962	Belongs to the TPP enzyme family
HHJ57_RS00090	COG0673	inositol 2-dehydrogenase activity
HHJ57_RS00100	COG0431	NADPH-dependent FMN reductase
HHJ57_RS00110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HHJ57_RS00120	COG3306	glycosyltransferase involved in LPS biosynthesis
HHJ57_RS00140	COG0174	glutamine synthetase
HHJ57_RS00165	COG4160	amino acid transport
HHJ57_RS00170	COG4215	(ABC) transporter
HHJ57_RS00175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHJ57_RS00180	COG1126	abc transporter atp-binding protein
HHJ57_RS00190	COG1393	Belongs to the ArsC family
HHJ57_RS00195	COG3036	rescue of stalled ribosome
HHJ57_RS00205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HHJ57_RS00210	COG4137	Cytochrome C assembly protein
HHJ57_RS00215	COG4536	flavin adenine dinucleotide binding
HHJ57_RS00220	COG0811	peptide transport
HHJ57_RS00225	COG0848	biopolymer transport protein
HHJ57_RS00240	COG0246	Mannitol dehydrogenase
HHJ57_RS00245	COG3722	fumarate hydratase activity
HHJ57_RS00255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHJ57_RS00255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHJ57_RS00260	COG3263	regulation of cellular component size
HHJ57_RS00265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HHJ57_RS00290	COG0740	serine-type endopeptidase activity
HHJ57_RS00300	COG1027	Aspartate ammonia-lyase
HHJ57_RS00305	COG1022	Amp-dependent synthetase and ligase
HHJ57_RS00310	COG0456	acetyltransferase
HHJ57_RS00315	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HHJ57_RS00335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHJ57_RS00340	COG1114	Component of the transport system for branched-chain amino acids
HHJ57_RS00345	COG2183	response to ionizing radiation
HHJ57_RS00370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHJ57_RS00375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HHJ57_RS00385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HHJ57_RS00390	COG1446	asparaginase
HHJ57_RS00395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HHJ57_RS00400	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HHJ57_RS00405	COG1447	Phosphotransferase system cellobiose-specific component IIA
HHJ57_RS00420	COG5645	(Lipo)protein
HHJ57_RS00425	COG0210	DNA helicase
HHJ57_RS00445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HHJ57_RS00480	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HHJ57_RS00485	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HHJ57_RS00490	COG3091	SprT-like family
HHJ57_RS00495	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHJ57_RS00500	COG0326	Molecular chaperone. Has ATPase activity
HHJ57_RS00515	COG0330	HflC and HflK could
HHJ57_RS00520	COG0330	HflC and HflK could
HHJ57_RS00530	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HHJ57_RS00535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HHJ57_RS00545	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HHJ57_RS00550	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HHJ57_RS00555	COG0470	DNA polymerase III
HHJ57_RS00560	COG0084	hydrolase, TatD family'
HHJ57_RS00570	COG1253	flavin adenine dinucleotide binding
HHJ57_RS00575	COG0254	rRNA binding
HHJ57_RS00580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HHJ57_RS00585	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HHJ57_RS00600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHJ57_RS00615	COG0537	adenosine 5'-monophosphoramidase activity
HHJ57_RS00620	COG2116	formate transmembrane transporter activity
HHJ57_RS00625	COG1882	Formate acetyltransferase
HHJ57_RS00630	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HHJ57_RS00635	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HHJ57_RS00645	COG2017	converts alpha-aldose to the beta-anomer
HHJ57_RS00655	COG1085	galactose-1-phosphate uridylyltransferase
HHJ57_RS00660	COG1879	ABC-type sugar transport system periplasmic component
HHJ57_RS00665	COG1129	ABC transporter
HHJ57_RS00670	COG4211	Belongs to the binding-protein-dependent transport system permease family
HHJ57_RS00685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHJ57_RS00690	COG1138	Cytochrome C-type biogenesis protein
HHJ57_RS00700	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HHJ57_RS00705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HHJ57_RS00710	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HHJ57_RS00715	COG4133	protoheme IX ABC transporter activity
HHJ57_RS00730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HHJ57_RS00735	COG0066	3-isopropylmalate dehydratase activity
HHJ57_RS00740	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HHJ57_RS00745	COG2233	PERMEase
HHJ57_RS00750	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HHJ57_RS00755	COG3161	chorismate lyase activity
HHJ57_RS00770	COG0107	imidazoleglycerol-phosphate synthase activity
HHJ57_RS00780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHJ57_RS00790	COG4804	nuclease activity
HHJ57_RS00795	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HHJ57_RS00795	COG0131	Imidazoleglycerol-phosphate dehydratase
HHJ57_RS00810	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HHJ57_RS00815	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HHJ57_RS00820	COG2226	methyltransferase
HHJ57_RS00825	COG0814	amino acid
HHJ57_RS00835	COG4783	chaperone-mediated protein folding
HHJ57_RS00855	COG1238	metal cluster binding
HHJ57_RS00880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HHJ57_RS00885	COG0110	maltose O-acetyltransferase activity
HHJ57_RS00890	COG1238	metal cluster binding
HHJ57_RS00900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HHJ57_RS00905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HHJ57_RS00910	COG1555	photosystem II stabilization
HHJ57_RS00915	COG2252	PERMEase
HHJ57_RS00920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HHJ57_RS00925	COG2814	Major facilitator Superfamily
HHJ57_RS00930	COG0385	Bile acid
HHJ57_RS00935	COG5002	protein histidine kinase activity
HHJ57_RS00935	COG2198	Histidine kinase
HHJ57_RS00935	COG0784	Response regulator, receiver
HHJ57_RS00955	COG0105	UTP biosynthetic process
HHJ57_RS00995	COG0681	Belongs to the peptidase S26 family
HHJ57_RS01015	COG0557	exoribonuclease II activity
HHJ57_RS01025	COG2814	Major facilitator Superfamily
HHJ57_RS01030	COG1566	PFAM secretion protein HlyD family protein
HHJ57_RS01035	COG1846	Transcriptional regulator
HHJ57_RS01050	COG1846	Transcriptional regulator
HHJ57_RS01060	COG2831	hemolysin activation secretion protein
HHJ57_RS01065	COG3210	domain, Protein
HHJ57_RS01065	COG3210	domain, Protein
HHJ57_RS01170	COG0697	spore germination
HHJ57_RS01185	COG0142	geranyltranstransferase activity
HHJ57_RS01190	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HHJ57_RS01200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHJ57_RS01205	COG0626	cystathionine gamma-synthase activity
HHJ57_RS01225	COG0582	viral genome integration into host DNA
HHJ57_RS01270	COG2974	May be involved in recombination
HHJ57_RS01340	COG3657	addiction module killer protein
HHJ57_RS01345	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HHJ57_RS01360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HHJ57_RS01385	COG1846	Transcriptional regulator
HHJ57_RS01530	COG0629	single-stranded DNA binding
HHJ57_RS01555	COG3617	BRO family, N-terminal domain
HHJ57_RS01565	COG0582	viral genome integration into host DNA
HHJ57_RS01585	COG0752	glycyl-tRNA synthetase alpha subunit
HHJ57_RS01590	COG4545	Glutaredoxin-related protein
HHJ57_RS01600	COG4804	nuclease activity
HHJ57_RS01605	COG2852	Protein conserved in bacteria
HHJ57_RS01630	COG3676	manually curated
HHJ57_RS01635	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HHJ57_RS01640	COG4972	Pilus assembly protein
HHJ57_RS01660	COG4796	Type ii and iii secretion system protein
HHJ57_RS01670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HHJ57_RS01675	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HHJ57_RS01680	COG4701	Protein of unknown function (DUF721)
HHJ57_RS01690	COG0653	protein targeting
HHJ57_RS01695	COG0494	nUDIX hydrolase
HHJ57_RS01700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HHJ57_RS01725	COG0582	viral genome integration into host DNA
HHJ57_RS01755	COG2026	Addiction module toxin, RelE StbE family
HHJ57_RS01815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HHJ57_RS01830	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HHJ57_RS01835	COG1328	CTP reductase activity
HHJ57_RS01835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HHJ57_RS01840	COG0602	queuosine metabolic process
HHJ57_RS01845	COG0084	hydrolase, TatD family'
HHJ57_RS01855	COG0805	protein transport
HHJ57_RS01860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HHJ57_RS01870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HHJ57_RS01880	COG2226	methyltransferase
HHJ57_RS01885	COG0471	metal ion transport
HHJ57_RS01890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HHJ57_RS01895	COG1575	Belongs to the MenA family. Type 1 subfamily
HHJ57_RS01900	COG1720	tRNA m6t6A37 methyltransferase activity
HHJ57_RS01905	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HHJ57_RS01910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HHJ57_RS01915	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HHJ57_RS01920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HHJ57_RS01940	COG0006	proline dipeptidase activity
HHJ57_RS01945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHJ57_RS01950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHJ57_RS01955	COG1879	ABC-type sugar transport system periplasmic component
HHJ57_RS01965	COG1129	ABC transporter
HHJ57_RS01970	COG1172	Belongs to the binding-protein-dependent transport system permease family
HHJ57_RS01995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HHJ57_RS02015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HHJ57_RS02025	COG1737	Transcriptional regulator
HHJ57_RS02030	COG2731	YhcH YjgK YiaL family protein
HHJ57_RS02040	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HHJ57_RS02050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HHJ57_RS02070	COG4771	TonB-dependent receptor
HHJ57_RS02075	COG3721	Heme iron utilization protein
HHJ57_RS02080	COG0748	coenzyme F420 binding
HHJ57_RS02085	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HHJ57_RS02090	COG1792	Involved in formation and maintenance of cell shape
HHJ57_RS02095	COG1077	Cell shape determining protein MreB Mrl
HHJ57_RS02165	COG0656	L-ascorbic acid biosynthetic process
HHJ57_RS02175	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HHJ57_RS02190	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ57_RS02195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HHJ57_RS02200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HHJ57_RS02205	COG0416	fatty acid biosynthetic process
HHJ57_RS02215	COG1399	metal-binding, possibly nucleic acid-binding protein
HHJ57_RS02220	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HHJ57_RS02225	COG0500	methyltransferase
HHJ57_RS02230	COG2830	Protein of unknown function (DUF452)
HHJ57_RS02240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HHJ57_RS02260	COG0545	Peptidyl-prolyl cis-trans isomerase
HHJ57_RS02265	COG3676	manually curated
HHJ57_RS02270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HHJ57_RS02275	COG0194	GDP metabolic process
HHJ57_RS02285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HHJ57_RS02290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HHJ57_RS02325	COG4991	sh3 domain protein
HHJ57_RS02330	COG0617	tRNA 3'-terminal CCA addition
HHJ57_RS02335	COG3955	Domain of unknown function (DUF1919)
HHJ57_RS02340	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HHJ57_RS02345	COG1984	allophanate hydrolase subunit 2
HHJ57_RS02350	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HHJ57_RS02355	COG1914	H( )-stimulated, divalent metal cation uptake system
HHJ57_RS02370	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HHJ57_RS02380	COG0708	Exodeoxyribonuclease III
HHJ57_RS02395	COG0616	signal peptide processing
HHJ57_RS02400	COG1840	ABC-type Fe3 transport system, periplasmic component
HHJ57_RS02405	COG1408	metallophosphoesterase
HHJ57_RS02410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HHJ57_RS02415	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HHJ57_RS02420	COG2863	cytochrome
HHJ57_RS02430	COG1199	ATP-dependent helicase activity
HHJ57_RS02435	COG1214	PFAM Peptidase M22, glycoprotease
HHJ57_RS02440	COG0318	PFAM AMP-dependent synthetase and ligase
HHJ57_RS02445	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HHJ57_RS02460	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HHJ57_RS02465	COG4988	ABC transporter
HHJ57_RS02470	COG0492	ferredoxin-NADP+ reductase activity
HHJ57_RS02475	COG3118	belongs to the thioredoxin family
HHJ57_RS02480	COG2610	gluconate transmembrane transporter activity
HHJ57_RS02485	COG3265	gluconokinase activity
HHJ57_RS02495	COG0733	neurotransmitter:sodium symporter activity
HHJ57_RS02500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HHJ57_RS02515	COG4658	electron transport chain
HHJ57_RS02520	COG4656	Part of a membrane complex involved in electron transport
HHJ57_RS02530	COG4657	Part of a membrane complex involved in electron transport
HHJ57_RS02535	COG1090	epimerase
HHJ57_RS02540	COG1438	arginine binding
HHJ57_RS02545	COG0039	L-malate dehydrogenase activity
HHJ57_RS02555	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HHJ57_RS02560	COG0517	IMP dehydrogenase activity
HHJ57_RS02560	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HHJ57_RS02590	COG0285	dihydrofolate synthase activity
HHJ57_RS02595	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HHJ57_RS02600	COG3140	Belongs to the UPF0181 family
HHJ57_RS02605	COG1278	Cold shock
HHJ57_RS02620	COG1609	Transcriptional regulator
HHJ57_RS02635	COG1067	ATP-dependent peptidase activity
HHJ57_RS02645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HHJ57_RS02650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HHJ57_RS02655	COG2252	PERMEase
HHJ57_RS02660	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HHJ57_RS02665	COG1074	ATP-dependent DNA helicase activity
HHJ57_RS02670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HHJ57_RS02685	COG1846	Transcriptional regulator
HHJ57_RS02685	COG1940	carbohydrate kinase activity
HHJ57_RS02695	COG0788	formyltetrahydrofolate deformylase activity
HHJ57_RS02700	COG0406	alpha-ribazole phosphatase activity
HHJ57_RS02710	COG0564	pseudouridine synthase activity
HHJ57_RS02725	COG0776	regulation of translation
HHJ57_RS02730	COG0791	NLP P60 protein
HHJ57_RS02760	COG0697	spore germination
HHJ57_RS02765	COG2925	Exonuclease
HHJ57_RS02780	COG3676	manually curated
HHJ57_RS02785	COG2969	positive regulation of protein catabolic process
HHJ57_RS02810	COG3098	single-species biofilm formation
HHJ57_RS02815	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HHJ57_RS02830	COG1611	Belongs to the LOG family
HHJ57_RS02835	COG4453	Protein conserved in bacteria
HHJ57_RS02845	COG1215	transferase activity, transferring glycosyl groups
HHJ57_RS02850	COG0842	Transport permease protein
HHJ57_RS02855	COG1131	(ABC) transporter
HHJ57_RS02860	COG3101	peptidyl-lysine hydroxylation
HHJ57_RS02870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HHJ57_RS02890	COG1523	belongs to the glycosyl hydrolase 13 family
HHJ57_RS02895	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HHJ57_RS02900	COG1640	4-alpha-glucanotransferase
HHJ57_RS02905	COG3152	Membrane
HHJ57_RS02920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHJ57_RS02925	COG0577	efflux transmembrane transporter activity
HHJ57_RS02925	COG1136	(ABC) transporter
HHJ57_RS02930	COG1538	Outer membrane efflux protein
HHJ57_RS02940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHJ57_RS02945	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHJ57_RS02950	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HHJ57_RS02955	COG2190	(PTS) system
HHJ57_RS02960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HHJ57_RS02965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ57_RS02970	COG1162	GTPase activity
HHJ57_RS02975	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HHJ57_RS02995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HHJ57_RS03000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HHJ57_RS03025	COG1522	sequence-specific DNA binding
HHJ57_RS03035	COG1346	cytolysis
HHJ57_RS03040	COG1380	Effector of murein hydrolase LrgA
HHJ57_RS03045	COG1525	nuclease
HHJ57_RS03055	COG2166	iron-sulfur cluster assembly
HHJ57_RS03060	COG2268	Band 7 protein
HHJ57_RS03075	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HHJ57_RS03080	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HHJ57_RS03080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HHJ57_RS03090	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HHJ57_RS03095	COG0617	tRNA 3'-terminal CCA addition
HHJ57_RS03100	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HHJ57_RS03105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHJ57_RS03105	COG0301	tRNA thio-modification
HHJ57_RS03115	COG0142	geranyltranstransferase activity
HHJ57_RS03125	COG1534	Rna-binding protein
HHJ57_RS03135	COG3217	Mosc domain protein beta barrel domain protein
HHJ57_RS03135	COG0633	Ferredoxin
HHJ57_RS03145	COG1605	Chorismate mutase
HHJ57_RS03145	COG0287	Prephenate dehydrogenase
HHJ57_RS03150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HHJ57_RS03155	COG0613	PHP domain protein
HHJ57_RS03160	COG0167	dihydroorotate dehydrogenase activity
HHJ57_RS03165	COG0308	aminopeptidase N
HHJ57_RS03170	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HHJ57_RS03215	COG0163	prenyltransferase activity
HHJ57_RS03225	COG1286	toxin biosynthetic process
HHJ57_RS03230	COG3092	negative regulation of chromosome organization
HHJ57_RS03240	COG0857	belongs to the CobB CobQ family
HHJ57_RS03240	COG0280	phosphate acetyltransferase
HHJ57_RS03265	COG0668	transmembrane transport
HHJ57_RS03270	COG0795	lipopolysaccharide-transporting ATPase activity
HHJ57_RS03275	COG0795	lipopolysaccharide-transporting ATPase activity
HHJ57_RS03300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHJ57_RS03305	COG2226	methyltransferase
HHJ57_RS03310	COG1944	ATP diphosphatase activity
HHJ57_RS03315	COG3105	Protein conserved in bacteria
HHJ57_RS03320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HHJ57_RS03335	COG0633	Ferredoxin
HHJ57_RS03345	COG1280	lysine exporter protein (LysE YggA)
HHJ57_RS03350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HHJ57_RS03355	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HHJ57_RS03360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHJ57_RS03370	COG0814	amino acid
HHJ57_RS03380	COG2062	phosphohistidine phosphatase, SixA
HHJ57_RS03390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HHJ57_RS03400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHJ57_RS03405	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHJ57_RS03405	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHJ57_RS03410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HHJ57_RS03450	COG2999	glutathione oxidoreductase activity
HHJ57_RS03485	COG1476	TRANSCRIPTIONal
HHJ57_RS03490	COG0582	viral genome integration into host DNA
HHJ57_RS03510	COG3306	glycosyltransferase involved in LPS biosynthesis
HHJ57_RS03515	COG3306	glycosyltransferase involved in LPS biosynthesis
HHJ57_RS03535	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HHJ57_RS03540	COG3683	transport system, periplasmic component
HHJ57_RS03545	COG0488	(ABC) transporter
HHJ57_RS03550	COG2195	Cleaves the N-terminal amino acid of tripeptides
HHJ57_RS03565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHJ57_RS03570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HHJ57_RS03575	COG1957	nucleoside hydrolase
HHJ57_RS03580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHJ57_RS03585	COG0670	Belongs to the BI1 family
HHJ57_RS03590	COG2920	part of a sulfur-relay system
HHJ57_RS03600	COG1121	(ABC) transporter
HHJ57_RS03605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHJ57_RS03610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHJ57_RS03615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HHJ57_RS03620	COG2949	membrane
HHJ57_RS03630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HHJ57_RS03635	COG4591	ABC-type transport system involved in lipoprotein release permease component
HHJ57_RS03640	COG1136	(ABC) transporter
HHJ57_RS03645	COG4591	ABC-type transport system involved in lipoprotein release permease component
HHJ57_RS03650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHJ57_RS03670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HHJ57_RS03680	COG1289	transmembrane transporter activity
HHJ57_RS03695	COG0314	molybdopterin synthase activity
HHJ57_RS03700	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HHJ57_RS03705	COG0315	cyclic pyranopterin monophosphate synthase activity
HHJ57_RS03750	COG1696	Membrane protein involved in D-alanine export
HHJ57_RS03760	COG0303	'Molybdopterin
HHJ57_RS03765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HHJ57_RS03770	COG2431	L-lysine efflux transmembrane transporter activity
HHJ57_RS03775	COG1528	Iron-storage protein
HHJ57_RS03780	COG1528	Iron-storage protein
HHJ57_RS03790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HHJ57_RS03795	COG0589	response to stress
HHJ57_RS03805	COG2171	N-acyltransferase activity
HHJ57_RS03810	COG0583	DNA-binding transcription factor activity
HHJ57_RS03820	COG0009	L-threonylcarbamoyladenylate synthase
HHJ57_RS03835	COG0792	nuclease activity
HHJ57_RS03840	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HHJ57_RS03845	COG2823	Periplasmic or secreted lipoprotein
HHJ57_RS03850	COG0210	DNA helicase
HHJ57_RS03870	COG0583	DNA-binding transcription factor activity
HHJ57_RS03875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HHJ57_RS03890	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HHJ57_RS03895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HHJ57_RS03910	COG0626	cystathionine gamma-synthase activity
HHJ57_RS03915	COG0450	alkyl hydroperoxide reductase
HHJ57_RS03920	COG3100	YcgL domain-containing protein
HHJ57_RS03925	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HHJ57_RS03925	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HHJ57_RS03930	COG1560	Kdo2-lipid A biosynthetic process
HHJ57_RS03935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHJ57_RS03940	COG3108	Peptidase M15
HHJ57_RS03945	COG2989	Protein conserved in bacteria
HHJ57_RS03950	COG0793	Belongs to the peptidase S41A family
HHJ57_RS03955	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HHJ57_RS03960	COG2995	paraquat-inducible protein a
HHJ57_RS03965	COG3008	intermembrane lipid transfer
HHJ57_RS03970	COG0187	DNA topoisomerase II activity
HHJ57_RS03980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HHJ57_RS03985	COG1328	CTP reductase activity
HHJ57_RS03990	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HHJ57_RS04015	COG0583	DNA-binding transcription factor activity
HHJ57_RS04020	COG0616	signal peptide processing
HHJ57_RS04025	COG0778	Nitroreductase
HHJ57_RS04045	COG0039	L-malate dehydrogenase activity
HHJ57_RS04050	COG0440	acetolactate synthase activity
HHJ57_RS04055	COG0028	Belongs to the TPP enzyme family
HHJ57_RS04060	COG1757	Na H antiporter
HHJ57_RS04075	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HHJ57_RS04100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHJ57_RS04125	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HHJ57_RS04130	COG0494	nUDIX hydrolase
HHJ57_RS04140	COG1876	peptidase activity
HHJ57_RS04145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHJ57_RS04150	COG1393	Belongs to the ArsC family
HHJ57_RS04170	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HHJ57_RS04175	COG0083	homoserine kinase activity
HHJ57_RS04180	COG0527	aspartate kinase activity
HHJ57_RS04180	COG0460	homoserine dehydrogenase
HHJ57_RS04190	COG0346	lactoylglutathione lyase activity
HHJ57_RS04195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HHJ57_RS04200	COG2056	Na+-H+ antiporter family
HHJ57_RS04205	COG0506	proline dehydrogenase activity
HHJ57_RS04205	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HHJ57_RS04205	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HHJ57_RS04210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HHJ57_RS04225	COG3945	hemerythrin HHE cation binding domain
HHJ57_RS04230	COG1862	Preprotein translocase
HHJ57_RS04235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHJ57_RS04240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHJ57_RS04245	COG0741	lytic transglycosylase activity
HHJ57_RS04260	COG4221	oxidoreductase activity
HHJ57_RS04265	COG2814	Major facilitator Superfamily
HHJ57_RS04290	COG3210	domain, Protein
HHJ57_RS04315	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HHJ57_RS04325	COG0583	DNA-binding transcription factor activity
HHJ57_RS04330	COG0642	Histidine kinase
HHJ57_RS04335	COG0745	RESPONSE REGULATOR receiver
HHJ57_RS04340	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HHJ57_RS04350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HHJ57_RS04355	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HHJ57_RS04365	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HHJ57_RS04370	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HHJ57_RS04385	COG3119	arylsulfatase activity
HHJ57_RS04395	COG2089	acid synthase
HHJ57_RS04410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HHJ57_RS04420	COG1621	beta-fructofuranosidase activity
HHJ57_RS04435	COG0802	atpase or kinase
HHJ57_RS04440	COG0860	N-Acetylmuramoyl-L-alanine amidase
HHJ57_RS04440	COG1388	LysM domain
HHJ57_RS04445	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HHJ57_RS04455	COG1923	regulation of RNA biosynthetic process
HHJ57_RS04460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HHJ57_RS04470	COG3099	Belongs to the UPF0263 family
HHJ57_RS04495	COG4735	regulation of single-species biofilm formation
HHJ57_RS04530	COG2378	regulation of single-species biofilm formation
HHJ57_RS04545	COG1741	Belongs to the pirin family
HHJ57_RS04550	COG2951	lytic endotransglycosylase activity
HHJ57_RS04555	COG1216	Glycosyl transferase, family 2
HHJ57_RS04560	COG1216	Glycosyl transferase, family 2
HHJ57_RS04570	COG3306	glycosyltransferase involved in LPS biosynthesis
HHJ57_RS04580	COG5039	Polysaccharide pyruvyl transferase
HHJ57_RS04585	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HHJ57_RS04590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HHJ57_RS04595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HHJ57_RS04595	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HHJ57_RS04600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHJ57_RS04600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHJ57_RS04605	COG0489	protein tyrosine kinase activity
HHJ57_RS04610	COG0672	)-iron permease
HHJ57_RS04625	COG1136	(ABC) transporter
HHJ57_RS04625	COG0577	efflux transmembrane transporter activity
HHJ57_RS04635	COG1136	(ABC) transporter
HHJ57_RS04640	COG0676	glucose-6-phosphate 1-epimerase activity
HHJ57_RS04655	COG3177	Filamentation induced by cAMP protein fic
HHJ57_RS04665	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HHJ57_RS04670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HHJ57_RS04675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HHJ57_RS04680	COG2885	chlorophyll binding
HHJ57_RS04680	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHJ57_RS04685	COG2824	Alkylphosphonate utilization operon protein PhnA
HHJ57_RS04690	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HHJ57_RS04695	COG1120	ATPase activity
HHJ57_RS04715	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
HHJ57_RS04720	COG4774	siderophore transport
HHJ57_RS04725	COG4774	siderophore transport
HHJ57_RS04735	COG0814	amino acid
HHJ57_RS04740	COG2964	Protein conserved in bacteria
HHJ57_RS04750	COG0469	pyruvate kinase activity
HHJ57_RS04755	COG0778	Nitroreductase
HHJ57_RS04765	COG0037	tRNA processing
HHJ57_RS04770	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HHJ57_RS04780	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHJ57_RS04785	COG0567	Dehydrogenase, E1 component
HHJ57_RS04790	COG0372	Belongs to the citrate synthase family
HHJ57_RS04795	COG3381	protein complex oligomerization
HHJ57_RS04800	COG2249	NAD(P)H dehydrogenase (quinone) activity
HHJ57_RS04810	COG0330	HflC and HflK could
HHJ57_RS04835	COG1940	carbohydrate kinase activity
HHJ57_RS04835	COG1846	Transcriptional regulator
HHJ57_RS04850	COG0497	DNA recombination
HHJ57_RS04855	COG0360	Binds together with S18 to 16S ribosomal RNA
HHJ57_RS04860	COG2965	DNA replication, synthesis of RNA primer
HHJ57_RS04885	COG1530	ribonuclease E activity
HHJ57_RS04945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HHJ57_RS04955	COG0024	Methionine aminopeptidase
HHJ57_RS04960	COG0316	Belongs to the HesB IscA family
HHJ57_RS04970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHJ57_RS04980	COG4166	transmembrane transport
HHJ57_RS04985	COG2832	Protein of unknown function (DUF454)
HHJ57_RS04990	COG0339	signal peptide processing
HHJ57_RS04995	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HHJ57_RS05000	COG1053	succinate dehydrogenase
HHJ57_RS05005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HHJ57_RS05015	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HHJ57_RS05025	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HHJ57_RS05030	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HHJ57_RS05035	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HHJ57_RS05050	COG1278	Cold shock
HHJ57_RS05055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HHJ57_RS05065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HHJ57_RS05070	COG5007	Belongs to the BolA IbaG family
HHJ57_RS05075	COG3113	response to antibiotic
HHJ57_RS05080	COG2854	intermembrane phospholipid transfer
HHJ57_RS05085	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HHJ57_RS05090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HHJ57_RS05095	COG1127	ABC transporter
HHJ57_RS05105	COG3117	lipopolysaccharide transmembrane transporter activity
HHJ57_RS05110	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HHJ57_RS05115	COG1137	ATPase activity
HHJ57_RS05120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ57_RS05135	COG2186	Transcriptional regulator
HHJ57_RS05150	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HHJ57_RS05165	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ57_RS05215	COG2267	carboxylic ester hydrolase activity
HHJ57_RS05230	COG0436	Aminotransferase
HHJ57_RS05250	COG0861	Integral membrane protein TerC family
HHJ57_RS05260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HHJ57_RS05265	COG2067	long-chain fatty acid transport protein
HHJ57_RS05275	COG2860	membrane
HHJ57_RS05285	COG0527	aspartate kinase activity
HHJ57_RS05290	COG2897	thiosulfate sulfurtransferase activity
HHJ57_RS05295	COG2391	methyltransferase activity
HHJ57_RS05300	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HHJ57_RS05315	COG3684	Belongs to the aldolase LacD family
HHJ57_RS05320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HHJ57_RS05325	COG1349	DNA-binding transcription factor activity
HHJ57_RS05335	COG3119	arylsulfatase activity
HHJ57_RS05340	COG0641	radical SAM
HHJ57_RS05350	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HHJ57_RS05355	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ57_RS05355	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ57_RS05360	COG3716	PTS system mannose fructose sorbose family IID component
HHJ57_RS05365	COG3715	PTS system
HHJ57_RS05370	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ57_RS05375	COG2222	sugar isomerase
HHJ57_RS05385	COG3119	arylsulfatase activity
HHJ57_RS05395	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ57_RS05405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHJ57_RS05410	COG0800	Aldolase
HHJ57_RS05415	COG0584	glycerophosphoryl diester phosphodiesterase
HHJ57_RS05420	COG3842	ATPase activity
HHJ57_RS05430	COG1177	transmembrane transport
HHJ57_RS05455	COG1509	lysine 2,3-aminomutase activity
HHJ57_RS05460	COG3266	domain, Protein
HHJ57_RS05460	COG3061	Opacity-associated protein A
HHJ57_RS05470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HHJ57_RS05475	COG2814	Major facilitator Superfamily
HHJ57_RS05480	COG4974	Belongs to the 'phage' integrase family
HHJ57_RS05485	COG0077	Prephenate dehydratase
HHJ57_RS05485	COG1605	Chorismate mutase
HHJ57_RS05490	COG3321	synthase
HHJ57_RS05490	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ57_RS05490	COG0604	alcohol dehydrogenase
HHJ57_RS05505	COG4221	oxidoreductase activity
HHJ57_RS05520	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HHJ57_RS05525	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HHJ57_RS05530	COG0849	cell division
HHJ57_RS05535	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HHJ57_RS05560	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HHJ57_RS05570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HHJ57_RS05580	COG0768	penicillin binding
HHJ57_RS05585	COG3116	cell division
HHJ57_RS05605	COG1444	tRNA N-acetyltransferase activity
HHJ57_RS05615	COG1702	phosphate starvation-inducible protein PhoH
HHJ57_RS05625	COG0204	Acyl-transferase
HHJ57_RS05635	COG0121	glutamine amidotransferase
HHJ57_RS05640	COG0814	amino acid
HHJ57_RS05645	COG1760	l-serine dehydratase
HHJ57_RS05650	COG1138	Cytochrome C-type biogenesis protein
HHJ57_RS05660	COG3088	subunit of a heme lyase
HHJ57_RS05660	COG4235	cytochrome complex assembly
HHJ57_RS05665	COG3088	subunit of a heme lyase
HHJ57_RS05665	COG4235	cytochrome complex assembly
HHJ57_RS05670	COG2081	HI0933 family
HHJ57_RS05680	COG3301	Polysulphide reductase, NrfD
HHJ57_RS05685	COG0437	4 iron, 4 sulfur cluster binding
HHJ57_RS05690	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HHJ57_RS05695	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HHJ57_RS05715	COG1686	Belongs to the peptidase S11 family
HHJ57_RS05725	COG0772	Belongs to the SEDS family
HHJ57_RS05730	COG0768	penicillin binding
HHJ57_RS05740	COG0799	negative regulation of ribosome biogenesis
HHJ57_RS05745	COG0513	Belongs to the DEAD box helicase family
HHJ57_RS05750	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HHJ57_RS05780	COG3842	ATPase activity
HHJ57_RS05820	COG1704	LemA family
HHJ57_RS05830	COG0277	FAD linked oxidase domain protein
HHJ57_RS05830	COG0247	lactate metabolic process
HHJ57_RS05845	COG3047	cAMP biosynthetic process
HHJ57_RS05860	COG1607	acyl-coa hydrolase
HHJ57_RS05865	COG2350	Protein conserved in bacteria
HHJ57_RS05885	COG1566	PFAM secretion protein HlyD family protein
HHJ57_RS05895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HHJ57_RS05900	COG0195	Participates in both transcription termination and antitermination
HHJ57_RS05915	COG0515	serine threonine protein kinase
HHJ57_RS05920	COG1115	amino acid carrier protein
HHJ57_RS05935	COG1940	carbohydrate kinase activity
HHJ57_RS05940	COG0671	phosphoesterase, PA-phosphatase related
HHJ57_RS05970	COG0307	riboflavin synthase, alpha
HHJ57_RS05980	COG0673	inositol 2-dehydrogenase activity
HHJ57_RS05985	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HHJ57_RS05990	COG0586	Pfam SNARE associated Golgi protein
HHJ57_RS05995	COG0322	excinuclease ABC activity
HHJ57_RS06000	COG1116	anion transmembrane transporter activity
HHJ57_RS06005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HHJ57_RS06010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HHJ57_RS06015	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HHJ57_RS06020	COG2835	tetraacyldisaccharide 4'-kinase activity
HHJ57_RS06025	COG1663	tetraacyldisaccharide 4'-kinase activity
HHJ57_RS06030	COG1132	(ABC) transporter
HHJ57_RS06035	COG2333	competence protein COMEC
HHJ57_RS06035	COG0658	competence protein
HHJ57_RS06045	COG0351	phosphomethylpyrimidine kinase
HHJ57_RS06050	COG0352	thiamine-phosphate diphosphorylase activity
HHJ57_RS06060	COG3468	outer membrane autotransporter barrel domain protein
HHJ57_RS06060	COG3266	domain, Protein
HHJ57_RS06065	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HHJ57_RS06070	COG3025	triphosphatase activity
HHJ57_RS06075	COG1392	Phosphate transport regulator
HHJ57_RS06080	COG0306	phosphate transporter
HHJ57_RS06085	COG0288	reversible hydration of carbon dioxide
HHJ57_RS06090	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HHJ57_RS06095	COG1448	Aminotransferase
HHJ57_RS06100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HHJ57_RS06105	COG3835	regulator
HHJ57_RS06110	COG2610	gluconate transmembrane transporter activity
HHJ57_RS06115	COG1929	Belongs to the glycerate kinase type-1 family
HHJ57_RS06140	COG0494	nUDIX hydrolase
HHJ57_RS06150	COG3041	Addiction module toxin RelE StbE family
HHJ57_RS06155	COG3077	Addiction module antitoxin, RelB DinJ family
HHJ57_RS06190	COG2932	Transcriptional regulator
HHJ57_RS06210	COG0305	Participates in initiation and elongation during chromosome replication
HHJ57_RS06215	COG3102	Protein conserved in bacteria
HHJ57_RS06225	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HHJ57_RS06230	COG4149	molybdate abc transporter
HHJ57_RS06235	COG0725	ABC transporter, periplasmic molybdate-binding protein
HHJ57_RS06240	COG2005	Transcriptional regulator
HHJ57_RS06245	COG0786	glutamate:sodium symporter activity
HHJ57_RS06260	COG0730	response to heat
HHJ57_RS06265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HHJ57_RS06275	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HHJ57_RS06280	COG1178	ABC-type Fe3 transport system permease component
HHJ57_RS06285	COG4143	(ABC) transporter
HHJ57_RS06290	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HHJ57_RS06300	COG3842	ATPase activity
HHJ57_RS06305	COG1176	ABC-type spermidine putrescine transport system, permease component I
HHJ57_RS06310	COG1177	transmembrane transport
HHJ57_RS06315	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HHJ57_RS06325	COG1733	regulation of RNA biosynthetic process
HHJ57_RS06330	COG0281	malic enzyme
HHJ57_RS06340	COG0673	inositol 2-dehydrogenase activity
HHJ57_RS06350	COG1175	transmembrane transport
HHJ57_RS06360	COG3842	ATPase activity
HHJ57_RS06365	COG2186	Transcriptional regulator
HHJ57_RS06370	COG0673	inositol 2-dehydrogenase activity
HHJ57_RS06375	COG1966	Carbon starvation protein
HHJ57_RS06380	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HHJ57_RS06385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HHJ57_RS06390	COG1560	Kdo2-lipid A biosynthetic process
HHJ57_RS06395	COG0730	response to heat
HHJ57_RS06400	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HHJ57_RS06410	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HHJ57_RS06410	COG3264	Mechanosensitive ion channel
HHJ57_RS06415	COG0318	PFAM AMP-dependent synthetase and ligase
HHJ57_RS06420	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HHJ57_RS06425	COG0596	Alpha beta hydrolase
HHJ57_RS06435	COG0716	FMN binding
HHJ57_RS06440	COG0735	belongs to the Fur family
HHJ57_RS06450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HHJ57_RS06455	COG3094	Invasion gene expression up-regulator, SirB
HHJ57_RS06470	COG4221	oxidoreductase activity
HHJ57_RS06495	COG2814	Major facilitator Superfamily
HHJ57_RS06510	COG2249	NAD(P)H dehydrogenase (quinone) activity
HHJ57_RS06515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HHJ57_RS06520	COG0525	valine-tRNA ligase activity
HHJ57_RS06535	COG4185	zeta toxin
HHJ57_RS06545	COG2153	protein acetylation
HHJ57_RS06550	COG2927	DNA polymerase III (CHI subunit)
HHJ57_RS06560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HHJ57_RS06565	COG0512	Glutamine amidotransferase of anthranilate synthase
HHJ57_RS06570	COG1942	4-Oxalocrotonate Tautomerase
HHJ57_RS06575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HHJ57_RS06580	COG0134	indole-3-glycerol-phosphate synthase activity
HHJ57_RS06580	COG0135	phosphoribosylanthranilate isomerase activity
HHJ57_RS06595	COG3422	double-strand break repair
HHJ57_RS06605	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HHJ57_RS06605	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HHJ57_RS06610	COG0516	GMP reductase activity
HHJ57_RS06610	COG0517	IMP dehydrogenase activity
HHJ57_RS06625	COG0519	Catalyzes the synthesis of GMP from XMP
HHJ57_RS06625	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HHJ57_RS06630	COG0582	viral genome integration into host DNA
HHJ57_RS06665	COG3646	Phage regulatory protein
HHJ57_RS06690	COG3179	chitinase
HHJ57_RS06875	COG1484	DNA-dependent DNA replication
HHJ57_RS06900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HHJ57_RS06980	COG2974	May be involved in recombination
HHJ57_RS07025	COG0270	DNA (cytosine-5-)-methyltransferase activity
HHJ57_RS07050	COG0251	oxidation-reduction process
HHJ57_RS07055	COG3021	interspecies interaction between organisms
HHJ57_RS07065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHJ57_RS07135	COG1982	Orn Lys Arg decarboxylase major
HHJ57_RS07140	COG0531	amino acid
HHJ57_RS07150	COG2217	Heavy metal translocating P-type atpase
HHJ57_RS07170	COG0437	4 iron, 4 sulfur cluster binding
HHJ57_RS07175	COG2864	formate dehydrogenase
HHJ57_RS07195	COG1687	branched-chain amino acid
HHJ57_RS07200	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HHJ57_RS07205	COG0583	DNA-binding transcription factor activity
HHJ57_RS07215	COG0471	metal ion transport
HHJ57_RS07225	COG1643	Atp-dependent helicase
HHJ57_RS07230	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HHJ57_RS07235	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HHJ57_RS07245	COG0484	heat shock protein binding
HHJ57_RS07255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHJ57_RS07265	COG0739	heme binding
HHJ57_RS07270	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HHJ57_RS07285	COG2850	peptidyl-arginine hydroxylation
HHJ57_RS07295	COG2867	negative regulation of translational initiation
HHJ57_RS07305	COG0012	GTP binding
HHJ57_RS07315	COG0531	amino acid
HHJ57_RS07320	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HHJ57_RS07330	COG3106	COG3106 Predicted ATPase
HHJ57_RS07335	COG4166	transmembrane transport
HHJ57_RS07340	COG4168	peptide transport system, permease
HHJ57_RS07345	COG4171	peptide transport system, permease
HHJ57_RS07350	COG4172	Belongs to the ABC transporter superfamily
HHJ57_RS07355	COG4172	Belongs to the ABC transporter superfamily
HHJ57_RS07360	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HHJ57_RS07380	COG2259	Doxx family
HHJ57_RS07395	COG0151	Belongs to the GarS family
HHJ57_RS07400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HHJ57_RS07405	COG0745	RESPONSE REGULATOR receiver
HHJ57_RS07425	COG0023	Translation Initiation Factor
HHJ57_RS07435	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HHJ57_RS07440	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HHJ57_RS07445	COG0776	regulation of translation
HHJ57_RS07450	COG0539	negative regulation of cytoplasmic translation
HHJ57_RS07465	COG0612	Peptidase, M16
HHJ57_RS07470	COG2990	Protein conserved in bacteria
HHJ57_RS07480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHJ57_RS07515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHJ57_RS07520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HHJ57_RS07525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHJ57_RS07530	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HHJ57_RS07540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HHJ57_RS07545	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HHJ57_RS07550	COG1012	belongs to the aldehyde dehydrogenase family
HHJ57_RS07550	COG1454	alcohol dehydrogenase
HHJ57_RS07565	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHJ57_RS07575	COG4178	(ABC) transporter
HHJ57_RS07585	COG5413	integral membrane protein
HHJ57_RS07590	COG4977	sequence-specific DNA binding
HHJ57_RS07590	COG1917	Cupin 2, conserved barrel domain protein
HHJ57_RS07595	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HHJ57_RS07600	COG1115	amino acid carrier protein
HHJ57_RS07610	COG0237	dephospho-CoA kinase activity
HHJ57_RS07610	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HHJ57_RS07620	COG1459	type II secretion system
HHJ57_RS07625	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ57_RS07625	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ57_RS07630	COG3715	PTS system
HHJ57_RS07635	COG3716	PTS system mannose fructose sorbose family IID component
HHJ57_RS07650	COG0328	RNA-DNA hybrid ribonuclease activity
HHJ57_RS07675	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HHJ57_RS07680	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HHJ57_RS07685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHJ57_RS07705	COG0495	leucyl-tRNA aminoacylation
HHJ57_RS07710	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HHJ57_RS07715	COG1466	dna polymerase III delta subunit
HHJ57_RS07725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HHJ57_RS07740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HHJ57_RS07745	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HHJ57_RS07750	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HHJ57_RS07760	COG0750	zinc metalloprotease
HHJ57_RS07765	COG0575	Belongs to the CDS family
HHJ57_RS07785	COG0528	UMP kinase activity
HHJ57_RS07790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HHJ57_RS07795	COG4969	Belongs to the N-Me-Phe pilin family
HHJ57_RS07800	COG3023	N-Acetylmuramoyl-L-alanine amidase
HHJ57_RS07810	COG0494	nUDIX hydrolase
HHJ57_RS07815	COG0730	response to heat
HHJ57_RS07830	COG0590	tRNA wobble adenosine to inosine editing
HHJ57_RS07835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HHJ57_RS07840	COG0363	glucosamine-6-phosphate deaminase activity
HHJ57_RS07845	COG1793	dna ligase
HHJ57_RS07885	COG1215	transferase activity, transferring glycosyl groups
HHJ57_RS07915	COG0602	queuosine metabolic process
HHJ57_RS07920	COG0720	synthase
HHJ57_RS07925	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HHJ57_RS07930	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HHJ57_RS07995	COG1598	PFAM Uncharacterised protein family UPF0150
HHJ57_RS08080	COG1783	phage Terminase large subunit
HHJ57_RS08085	COG3728	DNA packaging
HHJ57_RS08135	COG3617	BRO family, N-terminal domain
HHJ57_RS08220	COG3728	DNA packaging
HHJ57_RS08225	COG1783	phage Terminase large subunit
HHJ57_RS08230	COG3567	Phage-associated protein, HI1409 family
HHJ57_RS08235	COG2369	cell adhesion
HHJ57_RS08245	COG3566	protein conserved in bacteria
HHJ57_RS08400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HHJ57_RS08405	COG0165	Argininosuccinate lyase
HHJ57_RS08415	COG0642	Histidine kinase
HHJ57_RS08420	COG0745	RESPONSE REGULATOR receiver
HHJ57_RS08445	COG0196	riboflavin kinase activity
HHJ57_RS08460	COG0783	Belongs to the Dps family
HHJ57_RS08465	COG0512	Glutamine amidotransferase of anthranilate synthase
HHJ57_RS08475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HHJ57_RS08495	COG0251	oxidation-reduction process
HHJ57_RS08505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HHJ57_RS08510	COG0546	phosphoglycolate phosphatase activity
HHJ57_RS08520	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HHJ57_RS08530	COG0705	Rhomboid family
HHJ57_RS08535	COG1349	DNA-binding transcription factor activity
HHJ57_RS08540	COG0247	lactate metabolic process
HHJ57_RS08550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HHJ57_RS08555	COG2271	Major facilitator Superfamily
HHJ57_RS08560	COG0584	glycerophosphoryl diester phosphodiesterase
HHJ57_RS08565	COG0552	protein localization to endoplasmic reticulum
HHJ57_RS08570	COG0742	ribosomal rna small subunit methyltransferase
HHJ57_RS08575	COG0758	DNA mediated transformation
HHJ57_RS08580	COG3063	Type IV pilus biogenesis stability protein PilW
HHJ57_RS08590	COG0628	permease
HHJ57_RS08600	COG0521	Mo-molybdopterin cofactor biosynthetic process
HHJ57_RS08605	COG4589	Belongs to the CDS family
HHJ57_RS08615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HHJ57_RS08620	COG0471	metal ion transport
HHJ57_RS08620	COG0490	domain, Protein
HHJ57_RS08625	COG1426	Protein conserved in bacteria
HHJ57_RS08630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HHJ57_RS08640	COG2976	Protein conserved in bacteria
HHJ57_RS08645	COG3307	-O-antigen
HHJ57_RS08660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHJ57_RS08680	COG0312	modulator of DNA gyrase
HHJ57_RS08685	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HHJ57_RS08695	COG1271	oxidase subunit
HHJ57_RS08700	COG1294	oxidase, subunit
HHJ57_RS08710	COG3790	cyd operon protein YbgE
HHJ57_RS08720	COG0824	Thioesterase
HHJ57_RS08725	COG0811	peptide transport
HHJ57_RS08730	COG0848	biopolymer transport protein
HHJ57_RS08735	COG3064	Membrane
HHJ57_RS08755	COG2165	general secretion pathway protein
HHJ57_RS08760	COG4795	General secretion pathway protein
HHJ57_RS08775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HHJ57_RS08780	COG0561	phosphatase activity
HHJ57_RS08785	COG0235	Class ii aldolase
HHJ57_RS08790	COG3623	hexulose-6-phosphate isomerase
HHJ57_RS08815	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HHJ57_RS08890	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HHJ57_RS08905	COG2095	MarC family integral membrane protein
HHJ57_RS08910	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HHJ57_RS08915	COG1114	Component of the transport system for branched-chain amino acids
HHJ57_RS08920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HHJ57_RS08930	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HHJ57_RS08945	COG3956	TIGRFAM MazG family protein
HHJ57_RS08955	COG0583	DNA-binding transcription factor activity
HHJ57_RS08965	COG3119	arylsulfatase activity
HHJ57_RS08975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HHJ57_RS09010	COG0019	diaminopimelate decarboxylase activity
HHJ57_RS09045	COG2195	Cleaves the N-terminal amino acid of tripeptides
HHJ57_RS09065	COG3153	acetyltransferase
HHJ57_RS09080	COG1230	cation diffusion facilitator family transporter
HHJ57_RS09115	COG2271	Major facilitator Superfamily
HHJ57_RS09120	COG0483	inositol monophosphate 1-phosphatase activity
HHJ57_RS09130	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HHJ57_RS09135	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HHJ57_RS09145	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HHJ57_RS09170	COG0357	Ribosomal RNA small subunit methyltransferase G
HHJ57_RS09180	COG0716	FMN binding
HHJ57_RS09190	COG1494	fructose-1,6-bisphosphatase
HHJ57_RS09195	COG0187	DNA topoisomerase II activity
HHJ57_RS09205	COG4988	ABC transporter
HHJ57_RS09210	COG1132	(ABC) transporter
HHJ57_RS09215	COG1858	cytochrome C peroxidase
HHJ57_RS09225	COG0733	neurotransmitter:sodium symporter activity
HHJ57_RS09240	COG0551	DNA topoisomerase type I activity
HHJ57_RS09260	COG3070	regulator of competence-specific genes
HHJ57_RS09300	COG1609	Transcriptional regulator
HHJ57_RS09300	COG2207	Transcriptional regulator
HHJ57_RS09305	COG1070	Carbohydrate kinase
HHJ57_RS09310	COG2115	Belongs to the xylose isomerase family
HHJ57_RS09315	COG0436	Aminotransferase
HHJ57_RS09320	COG1757	Na H antiporter
HHJ57_RS09325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HHJ57_RS09340	COG1349	DNA-binding transcription factor activity
HHJ57_RS09345	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ57_RS09350	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ57_RS09360	COG3732	PTS system glucitol sorbitol-specific
HHJ57_RS09375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HHJ57_RS09390	COG4214	carbohydrate transport
HHJ57_RS09395	COG1129	ABC transporter
HHJ57_RS09400	COG4213	ABC transporter substrate-binding protein
HHJ57_RS09405	COG1194	a g-specific adenine glycosylase
HHJ57_RS09410	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HHJ57_RS09430	COG0598	Magnesium transport protein CorA
HHJ57_RS09435	COG0762	integral membrane protein
HHJ57_RS09445	COG2177	Part of the ABC transporter FtsEX involved in
HHJ57_RS09450	COG2884	Cell division ATP-binding protein ftsE
HHJ57_RS09460	COG0235	Class ii aldolase
HHJ57_RS09465	COG3623	hexulose-6-phosphate isomerase
HHJ57_RS09475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HHJ57_RS09480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HHJ57_RS09485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HHJ57_RS09490	COG2731	YhcH YjgK YiaL family protein
HHJ57_RS09495	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HHJ57_RS09500	COG1414	Transcriptional regulator
HHJ57_RS09510	COG1295	ribonuclease BN
HHJ57_RS09520	COG2197	response regulator
HHJ57_RS09530	COG0181	hydroxymethylbilane synthase activity
HHJ57_RS09540	COG2959	enzyme of heme biosynthesis
HHJ57_RS09545	COG3071	HemY protein
HHJ57_RS09550	COG3787	Belongs to the UPF0306 family
HHJ57_RS09555	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HHJ57_RS09560	COG0076	glutamate decarboxylase activity
HHJ57_RS09565	COG0606	chelatase, subunit chli
HHJ57_RS09570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HHJ57_RS09575	COG3171	Protein conserved in bacteria
HHJ57_RS09580	COG1921	L-seryl-tRNASec selenium transferase activity
HHJ57_RS09585	COG3276	selenocysteine insertion sequence binding
HHJ57_RS09595	COG1530	ribonuclease E activity
HHJ57_RS09605	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HHJ57_RS09615	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HHJ57_RS09635	COG0511	ligase activity, forming carbon-carbon bonds
HHJ57_RS09640	COG0439	Biotin carboxylase
HHJ57_RS09645	COG3924	membrane
HHJ57_RS09650	COG4145	pantothenate transmembrane transporter activity
HHJ57_RS09670	COG0538	isocitrate dehydrogenase activity
HHJ57_RS09685	COG3477	response to acidic pH
HHJ57_RS09690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HHJ57_RS09695	COG2818	Glycosylase
HHJ57_RS09700	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HHJ57_RS09710	COG3021	interspecies interaction between organisms
HHJ57_RS09720	COG1522	sequence-specific DNA binding
HHJ57_RS09760	COG3978	acetolactate synthase activity
HHJ57_RS09770	COG0561	phosphatase activity
HHJ57_RS09775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HHJ57_RS09780	COG2267	carboxylic ester hydrolase activity
HHJ57_RS09785	COG1309	transcriptional regulator
HHJ57_RS09790	COG0583	DNA-binding transcription factor activity
HHJ57_RS09795	COG0678	peroxiredoxin activity
HHJ57_RS09795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HHJ57_RS09805	COG0545	Peptidyl-prolyl cis-trans isomerase
HHJ57_RS09810	COG2964	Protein conserved in bacteria
HHJ57_RS09820	COG2923	Belongs to the DsrF TusC family
HHJ57_RS09850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HHJ57_RS09855	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HHJ57_RS09880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HHJ57_RS09885	COG0081	regulation of translation
HHJ57_RS09900	COG0085	RNA polymerase activity
HHJ57_RS09905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HHJ57_RS09910	COG1584	GPR1 FUN34 yaaH family protein
HHJ57_RS09915	COG0745	RESPONSE REGULATOR receiver
HHJ57_RS09920	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HHJ57_RS09935	COG3083	sulfuric ester hydrolase activity
HHJ57_RS09940	COG0402	S-adenosylhomocysteine deaminase activity
HHJ57_RS09950	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HHJ57_RS09955	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HHJ57_RS09960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HHJ57_RS09965	COG1561	YicC-like family, N-terminal region
HHJ57_RS09970	COG0354	folic acid binding
HHJ57_RS09980	COG3084	Protein conserved in bacteria
HHJ57_RS09985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HHJ57_RS09990	COG3085	chromosome segregation
HHJ57_RS09995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHJ57_RS10010	COG0560	Phosphoserine phosphatase
HHJ57_RS10020	COG0268	Binds directly to 16S ribosomal RNA
HHJ57_RS10025	COG0728	peptidoglycan biosynthetic process
HHJ57_RS10030	COG0729	surface antigen
HHJ57_RS10035	COG2911	Protein conserved in bacteria
HHJ57_RS10040	COG0248	Ppx GppA phosphatase
HHJ57_RS10045	COG0668	transmembrane transport
HHJ57_RS10050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HHJ57_RS10085	COG0433	COG0433 Predicted ATPase
HHJ57_RS10090	COG2990	Protein conserved in bacteria
HHJ57_RS10095	COG3676	manually curated
HHJ57_RS10100	COG0004	ammonium transporteR
HHJ57_RS10100	COG0004	ammonium transporteR
HHJ57_RS10125	COG2853	Lipoprotein
HHJ57_RS10135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HHJ57_RS10140	COG0513	Belongs to the DEAD box helicase family
HHJ57_RS10150	COG2837	iron assimilation
HHJ57_RS10165	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HHJ57_RS10170	COG1959	2 iron, 2 sulfur cluster binding
HHJ57_RS10180	COG0822	iron-sulfur transferase activity
HHJ57_RS10190	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HHJ57_RS10200	COG0443	Heat shock 70 kDa protein
HHJ57_RS10205	COG0633	Ferredoxin
HHJ57_RS10220	COG3716	PTS system mannose fructose sorbose family IID component
HHJ57_RS10225	COG3715	PTS system
HHJ57_RS10230	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ57_RS10230	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ57_RS10235	COG0561	phosphatase activity
HHJ57_RS10240	COG0463	Glycosyl transferase, family 2
HHJ57_RS10245	COG0859	PFAM glycosyl transferase family 9
HHJ57_RS10250	COG0228	four-way junction DNA binding
HHJ57_RS10255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HHJ57_RS10265	COG0335	large ribosomal subunit rRNA binding
HHJ57_RS10270	COG1368	sulfuric ester hydrolase activity
HHJ57_RS10280	COG0281	malic enzyme
HHJ57_RS10280	COG0280	phosphate acetyltransferase
HHJ57_RS10285	COG1187	pseudouridine synthase activity
HHJ57_RS10290	COG2814	Major facilitator Superfamily
HHJ57_RS10295	COG0789	Transcriptional regulator
HHJ57_RS10300	COG2194	sulfuric ester hydrolase activity
HHJ57_RS10305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HHJ57_RS10310	COG1045	serine acetyltransferase
HHJ57_RS10325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHJ57_RS10330	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HHJ57_RS10335	COG0778	Nitroreductase
HHJ57_RS10345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHJ57_RS10350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HHJ57_RS10355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HHJ57_RS10360	COG3719	Belongs to the RNase T2 family
HHJ57_RS10365	COG0126	phosphoglycerate kinase activity
HHJ57_RS10370	COG0191	fructose-bisphosphate aldolase activity
HHJ57_RS10380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHJ57_RS10385	COG1252	NADH dehydrogenase
HHJ57_RS10400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHJ57_RS10400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HHJ57_RS10405	COG0569	domain protein
HHJ57_RS10410	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HHJ57_RS10425	COG0513	Belongs to the DEAD box helicase family
HHJ57_RS10430	COG4785	May be involved in cell division
HHJ57_RS10440	COG3005	denitrification pathway
HHJ57_RS10445	COG3043	anaerobic respiration
HHJ57_RS10450	COG0348	domain, Protein
HHJ57_RS10455	COG0437	4 iron, 4 sulfur cluster binding
HHJ57_RS10460	COG0243	molybdopterin cofactor binding
HHJ57_RS10465	COG3062	negative regulation of establishment of protein localization
HHJ57_RS10470	COG3850	Histidine kinase
HHJ57_RS10485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HHJ57_RS10495	COG1040	competence protein
HHJ57_RS10500	COG2861	carbohydrate metabolic process
HHJ57_RS10505	COG4942	peptidase
HHJ57_RS10515	COG0425	Belongs to the sulfur carrier protein TusA family
HHJ57_RS10520	COG1739	Uncharacterized protein family UPF0029
HHJ57_RS10525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HHJ57_RS10530	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HHJ57_RS10585	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HHJ57_RS10605	COG0201	protein transport
HHJ57_RS10615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HHJ57_RS10620	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HHJ57_RS10625	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HHJ57_RS10630	COG0202	RNA polymerase activity
HHJ57_RS10635	COG0203	ribosomal protein L17
HHJ57_RS10645	COG2960	long-chain fatty acid transporting porin activity
HHJ57_RS10650	COG3172	ATPase kinase involved in NAD metabolism
HHJ57_RS10655	COG2129	metallophosphoesterase
HHJ57_RS10665	COG0582	viral genome integration into host DNA
HHJ57_RS10740	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HHJ57_RS10755	COG0732	type I restriction modification DNA specificity domain
HHJ57_RS10765	COG3056	Lipoprotein
HHJ57_RS10770	COG0271	Belongs to the BolA IbaG family
HHJ57_RS10785	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HHJ57_RS10790	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HHJ57_RS10795	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HHJ57_RS10805	COG1477	protein flavinylation
HHJ57_RS10810	COG2991	Protein conserved in bacteria
HHJ57_RS10820	COG1519	Transferase
HHJ57_RS10830	COG0786	glutamate:sodium symporter activity
HHJ57_RS10860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HHJ57_RS10870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HHJ57_RS10875	COG3068	Protein conserved in bacteria
HHJ57_RS10885	COG1349	DNA-binding transcription factor activity
HHJ57_RS10890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HHJ57_RS10900	COG0259	pyridoxamine-phosphate oxidase activity
HHJ57_RS10905	COG2814	Major facilitator Superfamily
HHJ57_RS10910	COG1763	Mo-molybdopterin cofactor biosynthetic process
HHJ57_RS10915	COG3086	response to oxidative stress
HHJ57_RS10920	COG3026	antisigma factor binding
HHJ57_RS10925	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HHJ57_RS10930	COG1595	DNA-templated transcription, initiation
HHJ57_RS10945	COG2226	methyltransferase
HHJ57_RS10970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HHJ57_RS10975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HHJ57_RS10980	COG0493	'glutamate synthase
HHJ57_RS10985	COG0067	glutamate synthase
HHJ57_RS10985	COG0069	glutamate synthase activity
HHJ57_RS10985	COG0070	glutamate synthase
HHJ57_RS10995	COG0859	PFAM glycosyl transferase family 9
HHJ57_RS11000	COG1132	(ABC) transporter
HHJ57_RS11010	COG0549	Belongs to the carbamate kinase family
HHJ57_RS11020	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HHJ57_RS11030	COG1304	FMN binding
HHJ57_RS11035	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HHJ57_RS11045	COG0583	DNA-binding transcription factor activity
HHJ57_RS11055	COG1304	FMN binding
HHJ57_RS11060	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HHJ57_RS11065	COG0666	response to abiotic stimulus
HHJ57_RS11090	COG0675	Transposase, IS605 OrfB family
HHJ57_RS11100	COG1126	abc transporter atp-binding protein
HHJ57_RS11105	COG0765	amino acid transport
HHJ57_RS11110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHJ57_RS11115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HHJ57_RS11125	COG3078	GTPase activator activity
HHJ57_RS11130	COG0564	pseudouridine synthase activity
HHJ57_RS11140	COG3201	nicotinamide mononucleotide transporter
HHJ57_RS11145	COG0673	inositol 2-dehydrogenase activity
HHJ57_RS11150	COG3676	manually curated
HHJ57_RS11160	COG3718	enzyme involved in inositol metabolism
HHJ57_RS11175	COG0456	acetyltransferase
HHJ57_RS11205	COG0738	Major facilitator superfamily
HHJ57_RS11210	COG0235	Class ii aldolase
HHJ57_RS11220	COG1070	Carbohydrate kinase
HHJ57_RS11225	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
HHJ57_RS11230	COG1349	DNA-binding transcription factor activity
HHJ57_RS11240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHJ57_RS11255	COG0859	PFAM glycosyl transferase family 9
HHJ57_RS11295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HHJ57_RS11310	COG3691	Protein conserved in bacteria
HHJ57_RS11315	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HHJ57_RS11320	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HHJ57_RS11325	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HHJ57_RS11330	COG0363	glucosamine-6-phosphate deaminase activity
HHJ57_RS11335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HHJ57_RS11340	COG1218	3'(2'),5'-bisphosphate nucleotidase
HHJ57_RS11345	COG1297	OPT oligopeptide transporter protein
HHJ57_RS11350	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HHJ57_RS11355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HHJ57_RS11360	COG1609	Transcriptional regulator
HHJ57_RS11365	COG1917	Cupin 2, conserved barrel domain protein
HHJ57_RS11375	COG1070	Carbohydrate kinase
HHJ57_RS11380	COG1129	ABC transporter
HHJ57_RS11385	COG1172	Belongs to the binding-protein-dependent transport system permease family
HHJ57_RS11390	COG1879	ABC-type sugar transport system periplasmic component
HHJ57_RS11405	COG0051	transcription antitermination factor activity, RNA binding
HHJ57_RS11415	COG0088	Forms part of the polypeptide exit tunnel
HHJ57_RS11425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HHJ57_RS11430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HHJ57_RS11440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HHJ57_RS11465	COG0582	viral genome integration into host DNA
HHJ57_RS11555	COG3728	DNA packaging
HHJ57_RS11630	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HHJ57_RS11635	COG0594	ribonuclease P activity