locus-tag	class	description
HHJ59_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HHJ59_RS00010	COG0592	DNA-directed DNA polymerase activity
HHJ59_RS00020	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HHJ59_RS00025	COG1381	Involved in DNA repair and RecF pathway recombination
HHJ59_RS00030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHJ59_RS00035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HHJ59_RS00040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HHJ59_RS00045	COG0252	asparaginase activity
HHJ59_RS00055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HHJ59_RS00075	COG3133	Outer membrane lipoprotein
HHJ59_RS00080	COG3962	Belongs to the TPP enzyme family
HHJ59_RS00090	COG0673	inositol 2-dehydrogenase activity
HHJ59_RS00100	COG0431	NADPH-dependent FMN reductase
HHJ59_RS00110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HHJ59_RS00120	COG3306	glycosyltransferase involved in LPS biosynthesis
HHJ59_RS00140	COG0174	glutamine synthetase
HHJ59_RS00165	COG4160	amino acid transport
HHJ59_RS00170	COG4215	(ABC) transporter
HHJ59_RS00175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHJ59_RS00180	COG1126	abc transporter atp-binding protein
HHJ59_RS00190	COG1393	Belongs to the ArsC family
HHJ59_RS00195	COG3036	rescue of stalled ribosome
HHJ59_RS00205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HHJ59_RS00210	COG4137	Cytochrome C assembly protein
HHJ59_RS00215	COG4536	flavin adenine dinucleotide binding
HHJ59_RS00220	COG0811	peptide transport
HHJ59_RS00225	COG0848	biopolymer transport protein
HHJ59_RS00240	COG0246	Mannitol dehydrogenase
HHJ59_RS00245	COG3722	fumarate hydratase activity
HHJ59_RS00255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHJ59_RS00255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHJ59_RS00260	COG3263	regulation of cellular component size
HHJ59_RS00265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HHJ59_RS00290	COG0740	serine-type endopeptidase activity
HHJ59_RS00300	COG1027	Aspartate ammonia-lyase
HHJ59_RS00305	COG1022	Amp-dependent synthetase and ligase
HHJ59_RS00310	COG0456	acetyltransferase
HHJ59_RS00315	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HHJ59_RS00335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHJ59_RS00340	COG1114	Component of the transport system for branched-chain amino acids
HHJ59_RS00345	COG2183	response to ionizing radiation
HHJ59_RS00370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHJ59_RS00375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HHJ59_RS00385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HHJ59_RS00390	COG1446	asparaginase
HHJ59_RS00395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HHJ59_RS00400	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HHJ59_RS00405	COG1447	Phosphotransferase system cellobiose-specific component IIA
HHJ59_RS00420	COG5645	(Lipo)protein
HHJ59_RS00425	COG0210	DNA helicase
HHJ59_RS00440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HHJ59_RS00475	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HHJ59_RS00480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HHJ59_RS00485	COG3091	SprT-like family
HHJ59_RS00490	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHJ59_RS00495	COG0326	Molecular chaperone. Has ATPase activity
HHJ59_RS00510	COG0330	HflC and HflK could
HHJ59_RS00515	COG0330	HflC and HflK could
HHJ59_RS00525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HHJ59_RS00530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HHJ59_RS00540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HHJ59_RS00545	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HHJ59_RS00550	COG0470	DNA polymerase III
HHJ59_RS00555	COG0084	hydrolase, TatD family'
HHJ59_RS00565	COG1253	flavin adenine dinucleotide binding
HHJ59_RS00570	COG0254	rRNA binding
HHJ59_RS00575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HHJ59_RS00580	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HHJ59_RS00595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHJ59_RS00610	COG0537	adenosine 5'-monophosphoramidase activity
HHJ59_RS00615	COG2116	formate transmembrane transporter activity
HHJ59_RS00620	COG1882	Formate acetyltransferase
HHJ59_RS00625	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HHJ59_RS00630	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HHJ59_RS00640	COG2017	converts alpha-aldose to the beta-anomer
HHJ59_RS00650	COG1085	galactose-1-phosphate uridylyltransferase
HHJ59_RS00655	COG1879	ABC-type sugar transport system periplasmic component
HHJ59_RS00660	COG1129	ABC transporter
HHJ59_RS00665	COG4211	Belongs to the binding-protein-dependent transport system permease family
HHJ59_RS00680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHJ59_RS00685	COG1138	Cytochrome C-type biogenesis protein
HHJ59_RS00695	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HHJ59_RS00700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HHJ59_RS00705	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HHJ59_RS00710	COG4133	protoheme IX ABC transporter activity
HHJ59_RS00725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HHJ59_RS00730	COG0066	3-isopropylmalate dehydratase activity
HHJ59_RS00735	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HHJ59_RS00740	COG2233	PERMEase
HHJ59_RS00745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HHJ59_RS00750	COG3161	chorismate lyase activity
HHJ59_RS00765	COG0107	imidazoleglycerol-phosphate synthase activity
HHJ59_RS00775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHJ59_RS00785	COG4804	nuclease activity
HHJ59_RS00790	COG0131	Imidazoleglycerol-phosphate dehydratase
HHJ59_RS00790	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HHJ59_RS00805	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HHJ59_RS00810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HHJ59_RS00815	COG2226	methyltransferase
HHJ59_RS00820	COG0814	amino acid
HHJ59_RS00830	COG4783	chaperone-mediated protein folding
HHJ59_RS00850	COG1238	metal cluster binding
HHJ59_RS00875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HHJ59_RS00880	COG0110	maltose O-acetyltransferase activity
HHJ59_RS00885	COG1238	metal cluster binding
HHJ59_RS00895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HHJ59_RS00900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HHJ59_RS00905	COG1555	photosystem II stabilization
HHJ59_RS00910	COG2252	PERMEase
HHJ59_RS00920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HHJ59_RS00925	COG2814	Major facilitator Superfamily
HHJ59_RS00930	COG0385	Bile acid
HHJ59_RS00935	COG0784	Response regulator, receiver
HHJ59_RS00935	COG2198	Histidine kinase
HHJ59_RS00935	COG5002	protein histidine kinase activity
HHJ59_RS00955	COG0105	UTP biosynthetic process
HHJ59_RS00995	COG0681	Belongs to the peptidase S26 family
HHJ59_RS01015	COG0557	exoribonuclease II activity
HHJ59_RS01025	COG2814	Major facilitator Superfamily
HHJ59_RS01030	COG1566	PFAM secretion protein HlyD family protein
HHJ59_RS01035	COG1846	Transcriptional regulator
HHJ59_RS01050	COG1846	Transcriptional regulator
HHJ59_RS01060	COG2831	hemolysin activation secretion protein
HHJ59_RS01065	COG3210	domain, Protein
HHJ59_RS01065	COG3210	domain, Protein
HHJ59_RS01170	COG0697	spore germination
HHJ59_RS01185	COG0142	geranyltranstransferase activity
HHJ59_RS01190	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HHJ59_RS01200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHJ59_RS01205	COG0626	cystathionine gamma-synthase activity
HHJ59_RS01225	COG0582	viral genome integration into host DNA
HHJ59_RS01270	COG2974	May be involved in recombination
HHJ59_RS01340	COG3657	addiction module killer protein
HHJ59_RS01345	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HHJ59_RS01360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HHJ59_RS01385	COG1846	Transcriptional regulator
HHJ59_RS01530	COG0629	single-stranded DNA binding
HHJ59_RS01555	COG3617	BRO family, N-terminal domain
HHJ59_RS01565	COG0582	viral genome integration into host DNA
HHJ59_RS01585	COG0752	glycyl-tRNA synthetase alpha subunit
HHJ59_RS01590	COG4545	Glutaredoxin-related protein
HHJ59_RS01600	COG4804	nuclease activity
HHJ59_RS01605	COG2852	Protein conserved in bacteria
HHJ59_RS01630	COG3676	manually curated
HHJ59_RS01635	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HHJ59_RS01640	COG4972	Pilus assembly protein
HHJ59_RS01660	COG4796	Type ii and iii secretion system protein
HHJ59_RS01670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HHJ59_RS01675	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HHJ59_RS01680	COG4701	Protein of unknown function (DUF721)
HHJ59_RS01690	COG0653	protein targeting
HHJ59_RS01695	COG0494	nUDIX hydrolase
HHJ59_RS01700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HHJ59_RS01725	COG0582	viral genome integration into host DNA
HHJ59_RS01755	COG2026	Addiction module toxin, RelE StbE family
HHJ59_RS01825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HHJ59_RS01840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HHJ59_RS01845	COG1328	CTP reductase activity
HHJ59_RS01845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HHJ59_RS01850	COG0602	queuosine metabolic process
HHJ59_RS01855	COG0084	hydrolase, TatD family'
HHJ59_RS01865	COG0805	protein transport
HHJ59_RS01870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HHJ59_RS01880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HHJ59_RS01890	COG2226	methyltransferase
HHJ59_RS01895	COG0471	metal ion transport
HHJ59_RS01900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HHJ59_RS01905	COG1575	Belongs to the MenA family. Type 1 subfamily
HHJ59_RS01910	COG1720	tRNA m6t6A37 methyltransferase activity
HHJ59_RS01915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HHJ59_RS01920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HHJ59_RS01925	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HHJ59_RS01930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HHJ59_RS01950	COG0006	proline dipeptidase activity
HHJ59_RS01955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHJ59_RS01960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHJ59_RS01965	COG1879	ABC-type sugar transport system periplasmic component
HHJ59_RS01975	COG1129	ABC transporter
HHJ59_RS01980	COG1172	Belongs to the binding-protein-dependent transport system permease family
HHJ59_RS02005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HHJ59_RS02025	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HHJ59_RS02035	COG1737	Transcriptional regulator
HHJ59_RS02040	COG2731	YhcH YjgK YiaL family protein
HHJ59_RS02050	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HHJ59_RS02060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HHJ59_RS02080	COG4771	TonB-dependent receptor
HHJ59_RS02085	COG3721	Heme iron utilization protein
HHJ59_RS02090	COG0748	coenzyme F420 binding
HHJ59_RS02095	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HHJ59_RS02100	COG1792	Involved in formation and maintenance of cell shape
HHJ59_RS02105	COG1077	Cell shape determining protein MreB Mrl
HHJ59_RS02175	COG0656	L-ascorbic acid biosynthetic process
HHJ59_RS02185	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HHJ59_RS02200	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ59_RS02205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HHJ59_RS02210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HHJ59_RS02215	COG0416	fatty acid biosynthetic process
HHJ59_RS02225	COG1399	metal-binding, possibly nucleic acid-binding protein
HHJ59_RS02230	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HHJ59_RS02235	COG0500	methyltransferase
HHJ59_RS02240	COG2830	Protein of unknown function (DUF452)
HHJ59_RS02250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HHJ59_RS02270	COG0545	Peptidyl-prolyl cis-trans isomerase
HHJ59_RS02275	COG3676	manually curated
HHJ59_RS02280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HHJ59_RS02285	COG0194	GDP metabolic process
HHJ59_RS02295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HHJ59_RS02300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HHJ59_RS02335	COG4991	sh3 domain protein
HHJ59_RS02340	COG0617	tRNA 3'-terminal CCA addition
HHJ59_RS02345	COG3955	Domain of unknown function (DUF1919)
HHJ59_RS02350	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HHJ59_RS02355	COG1984	allophanate hydrolase subunit 2
HHJ59_RS02360	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HHJ59_RS02365	COG1914	H( )-stimulated, divalent metal cation uptake system
HHJ59_RS02380	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HHJ59_RS02390	COG0708	Exodeoxyribonuclease III
HHJ59_RS02405	COG0616	signal peptide processing
HHJ59_RS02410	COG1840	ABC-type Fe3 transport system, periplasmic component
HHJ59_RS02415	COG1408	metallophosphoesterase
HHJ59_RS02420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HHJ59_RS02425	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HHJ59_RS02430	COG2863	cytochrome
HHJ59_RS02440	COG1199	ATP-dependent helicase activity
HHJ59_RS02445	COG1214	PFAM Peptidase M22, glycoprotease
HHJ59_RS02450	COG0318	PFAM AMP-dependent synthetase and ligase
HHJ59_RS02455	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HHJ59_RS02470	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HHJ59_RS02475	COG4988	ABC transporter
HHJ59_RS02480	COG0492	ferredoxin-NADP+ reductase activity
HHJ59_RS02485	COG3118	belongs to the thioredoxin family
HHJ59_RS02490	COG2610	gluconate transmembrane transporter activity
HHJ59_RS02495	COG3265	gluconokinase activity
HHJ59_RS02505	COG0733	neurotransmitter:sodium symporter activity
HHJ59_RS02510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HHJ59_RS02525	COG4658	electron transport chain
HHJ59_RS02530	COG4656	Part of a membrane complex involved in electron transport
HHJ59_RS02540	COG4657	Part of a membrane complex involved in electron transport
HHJ59_RS02545	COG1090	epimerase
HHJ59_RS02550	COG1438	arginine binding
HHJ59_RS02555	COG0039	L-malate dehydrogenase activity
HHJ59_RS02565	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HHJ59_RS02570	COG0517	IMP dehydrogenase activity
HHJ59_RS02570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HHJ59_RS02600	COG0285	dihydrofolate synthase activity
HHJ59_RS02605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HHJ59_RS02610	COG3140	Belongs to the UPF0181 family
HHJ59_RS02615	COG1278	Cold shock
HHJ59_RS02630	COG1609	Transcriptional regulator
HHJ59_RS02645	COG1067	ATP-dependent peptidase activity
HHJ59_RS02655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HHJ59_RS02660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HHJ59_RS02665	COG2252	PERMEase
HHJ59_RS02670	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HHJ59_RS02675	COG1074	ATP-dependent DNA helicase activity
HHJ59_RS02680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HHJ59_RS02695	COG1940	carbohydrate kinase activity
HHJ59_RS02695	COG1846	Transcriptional regulator
HHJ59_RS02705	COG0788	formyltetrahydrofolate deformylase activity
HHJ59_RS02710	COG0406	alpha-ribazole phosphatase activity
HHJ59_RS02720	COG0564	pseudouridine synthase activity
HHJ59_RS02735	COG0776	regulation of translation
HHJ59_RS02740	COG0791	NLP P60 protein
HHJ59_RS02770	COG0697	spore germination
HHJ59_RS02775	COG2925	Exonuclease
HHJ59_RS02790	COG3676	manually curated
HHJ59_RS02795	COG2969	positive regulation of protein catabolic process
HHJ59_RS02820	COG3098	single-species biofilm formation
HHJ59_RS02825	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HHJ59_RS02840	COG1611	Belongs to the LOG family
HHJ59_RS02845	COG4453	Protein conserved in bacteria
HHJ59_RS02855	COG1215	transferase activity, transferring glycosyl groups
HHJ59_RS02860	COG0842	Transport permease protein
HHJ59_RS02865	COG1131	(ABC) transporter
HHJ59_RS02870	COG3101	peptidyl-lysine hydroxylation
HHJ59_RS02880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HHJ59_RS02900	COG1523	belongs to the glycosyl hydrolase 13 family
HHJ59_RS02905	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HHJ59_RS02910	COG1640	4-alpha-glucanotransferase
HHJ59_RS02915	COG3152	Membrane
HHJ59_RS02930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHJ59_RS02935	COG1136	(ABC) transporter
HHJ59_RS02935	COG0577	efflux transmembrane transporter activity
HHJ59_RS02940	COG1538	Outer membrane efflux protein
HHJ59_RS02950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHJ59_RS02955	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHJ59_RS02960	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HHJ59_RS02965	COG2190	(PTS) system
HHJ59_RS02970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HHJ59_RS02975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ59_RS02980	COG1162	GTPase activity
HHJ59_RS02985	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HHJ59_RS03005	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HHJ59_RS03010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HHJ59_RS03035	COG1522	sequence-specific DNA binding
HHJ59_RS03045	COG1346	cytolysis
HHJ59_RS03050	COG1380	Effector of murein hydrolase LrgA
HHJ59_RS03055	COG1525	nuclease
HHJ59_RS03065	COG2166	iron-sulfur cluster assembly
HHJ59_RS03070	COG2268	Band 7 protein
HHJ59_RS03085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HHJ59_RS03090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HHJ59_RS03090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HHJ59_RS03100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HHJ59_RS03105	COG0617	tRNA 3'-terminal CCA addition
HHJ59_RS03110	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HHJ59_RS03115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHJ59_RS03115	COG0301	tRNA thio-modification
HHJ59_RS03125	COG0142	geranyltranstransferase activity
HHJ59_RS03135	COG1534	Rna-binding protein
HHJ59_RS03145	COG0633	Ferredoxin
HHJ59_RS03145	COG3217	Mosc domain protein beta barrel domain protein
HHJ59_RS03155	COG1605	Chorismate mutase
HHJ59_RS03155	COG0287	Prephenate dehydrogenase
HHJ59_RS03160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HHJ59_RS03165	COG0613	PHP domain protein
HHJ59_RS03170	COG0167	dihydroorotate dehydrogenase activity
HHJ59_RS03175	COG0308	aminopeptidase N
HHJ59_RS03180	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HHJ59_RS03225	COG0163	prenyltransferase activity
HHJ59_RS03235	COG1286	toxin biosynthetic process
HHJ59_RS03240	COG3092	negative regulation of chromosome organization
HHJ59_RS03250	COG0280	phosphate acetyltransferase
HHJ59_RS03250	COG0857	belongs to the CobB CobQ family
HHJ59_RS03275	COG0668	transmembrane transport
HHJ59_RS03280	COG0795	lipopolysaccharide-transporting ATPase activity
HHJ59_RS03285	COG0795	lipopolysaccharide-transporting ATPase activity
HHJ59_RS03310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHJ59_RS03315	COG2226	methyltransferase
HHJ59_RS03320	COG1944	ATP diphosphatase activity
HHJ59_RS03325	COG3105	Protein conserved in bacteria
HHJ59_RS03330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HHJ59_RS03345	COG0633	Ferredoxin
HHJ59_RS03355	COG1280	lysine exporter protein (LysE YggA)
HHJ59_RS03360	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HHJ59_RS03365	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HHJ59_RS03370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHJ59_RS03380	COG0814	amino acid
HHJ59_RS03390	COG2062	phosphohistidine phosphatase, SixA
HHJ59_RS03400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HHJ59_RS03410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHJ59_RS03415	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHJ59_RS03415	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHJ59_RS03420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HHJ59_RS03460	COG2999	glutathione oxidoreductase activity
HHJ59_RS03495	COG1476	TRANSCRIPTIONal
HHJ59_RS03500	COG0582	viral genome integration into host DNA
HHJ59_RS03520	COG3306	glycosyltransferase involved in LPS biosynthesis
HHJ59_RS03525	COG3306	glycosyltransferase involved in LPS biosynthesis
HHJ59_RS03545	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HHJ59_RS03550	COG3683	transport system, periplasmic component
HHJ59_RS03555	COG0488	(ABC) transporter
HHJ59_RS03560	COG2195	Cleaves the N-terminal amino acid of tripeptides
HHJ59_RS03575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHJ59_RS03580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HHJ59_RS03585	COG1957	nucleoside hydrolase
HHJ59_RS03590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHJ59_RS03595	COG0670	Belongs to the BI1 family
HHJ59_RS03600	COG2920	part of a sulfur-relay system
HHJ59_RS03610	COG1121	(ABC) transporter
HHJ59_RS03615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHJ59_RS03620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHJ59_RS03625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HHJ59_RS03630	COG2949	membrane
HHJ59_RS03640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HHJ59_RS03645	COG4591	ABC-type transport system involved in lipoprotein release permease component
HHJ59_RS03650	COG1136	(ABC) transporter
HHJ59_RS03655	COG4591	ABC-type transport system involved in lipoprotein release permease component
HHJ59_RS03660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHJ59_RS03680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HHJ59_RS03690	COG1289	transmembrane transporter activity
HHJ59_RS03705	COG0314	molybdopterin synthase activity
HHJ59_RS03710	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HHJ59_RS03715	COG0315	cyclic pyranopterin monophosphate synthase activity
HHJ59_RS03760	COG1696	Membrane protein involved in D-alanine export
HHJ59_RS03770	COG0303	'Molybdopterin
HHJ59_RS03775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HHJ59_RS03780	COG2431	L-lysine efflux transmembrane transporter activity
HHJ59_RS03785	COG1528	Iron-storage protein
HHJ59_RS03790	COG1528	Iron-storage protein
HHJ59_RS03800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HHJ59_RS03805	COG0589	response to stress
HHJ59_RS03815	COG2171	N-acyltransferase activity
HHJ59_RS03820	COG0583	DNA-binding transcription factor activity
HHJ59_RS03830	COG0009	L-threonylcarbamoyladenylate synthase
HHJ59_RS03845	COG0792	nuclease activity
HHJ59_RS03850	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HHJ59_RS03855	COG2823	Periplasmic or secreted lipoprotein
HHJ59_RS03860	COG0210	DNA helicase
HHJ59_RS03880	COG0583	DNA-binding transcription factor activity
HHJ59_RS03885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HHJ59_RS03900	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HHJ59_RS03905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HHJ59_RS03920	COG0626	cystathionine gamma-synthase activity
HHJ59_RS03925	COG0450	alkyl hydroperoxide reductase
HHJ59_RS03930	COG3100	YcgL domain-containing protein
HHJ59_RS03935	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HHJ59_RS03935	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HHJ59_RS03940	COG1560	Kdo2-lipid A biosynthetic process
HHJ59_RS03945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHJ59_RS03950	COG3108	Peptidase M15
HHJ59_RS03955	COG2989	Protein conserved in bacteria
HHJ59_RS03960	COG0793	Belongs to the peptidase S41A family
HHJ59_RS03965	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HHJ59_RS03970	COG2995	paraquat-inducible protein a
HHJ59_RS03975	COG3008	intermembrane lipid transfer
HHJ59_RS03980	COG0187	DNA topoisomerase II activity
HHJ59_RS03990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HHJ59_RS03995	COG1328	CTP reductase activity
HHJ59_RS04000	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HHJ59_RS04025	COG0583	DNA-binding transcription factor activity
HHJ59_RS04030	COG0616	signal peptide processing
HHJ59_RS04035	COG0778	Nitroreductase
HHJ59_RS04055	COG0039	L-malate dehydrogenase activity
HHJ59_RS04060	COG0440	acetolactate synthase activity
HHJ59_RS04065	COG0028	Belongs to the TPP enzyme family
HHJ59_RS04070	COG1757	Na H antiporter
HHJ59_RS04085	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HHJ59_RS04110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHJ59_RS04135	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HHJ59_RS04140	COG0494	nUDIX hydrolase
HHJ59_RS04150	COG1876	peptidase activity
HHJ59_RS04155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHJ59_RS04160	COG1393	Belongs to the ArsC family
HHJ59_RS04180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HHJ59_RS04185	COG0083	homoserine kinase activity
HHJ59_RS04190	COG0460	homoserine dehydrogenase
HHJ59_RS04190	COG0527	aspartate kinase activity
HHJ59_RS04200	COG0346	lactoylglutathione lyase activity
HHJ59_RS04205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HHJ59_RS04210	COG2056	Na+-H+ antiporter family
HHJ59_RS04215	COG0506	proline dehydrogenase activity
HHJ59_RS04215	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HHJ59_RS04215	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HHJ59_RS04220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HHJ59_RS04235	COG3945	hemerythrin HHE cation binding domain
HHJ59_RS04240	COG1862	Preprotein translocase
HHJ59_RS04245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHJ59_RS04250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHJ59_RS04255	COG0741	lytic transglycosylase activity
HHJ59_RS04270	COG4221	oxidoreductase activity
HHJ59_RS04275	COG2814	Major facilitator Superfamily
HHJ59_RS04300	COG3210	domain, Protein
HHJ59_RS04325	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HHJ59_RS04335	COG0583	DNA-binding transcription factor activity
HHJ59_RS04340	COG0642	Histidine kinase
HHJ59_RS04345	COG0745	RESPONSE REGULATOR receiver
HHJ59_RS04350	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HHJ59_RS04360	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HHJ59_RS04365	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HHJ59_RS04375	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HHJ59_RS04380	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HHJ59_RS04405	COG2089	acid synthase
HHJ59_RS04420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HHJ59_RS04430	COG1621	beta-fructofuranosidase activity
HHJ59_RS04445	COG0802	atpase or kinase
HHJ59_RS04450	COG1388	LysM domain
HHJ59_RS04450	COG0860	N-Acetylmuramoyl-L-alanine amidase
HHJ59_RS04455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HHJ59_RS04465	COG1923	regulation of RNA biosynthetic process
HHJ59_RS04470	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HHJ59_RS04480	COG3099	Belongs to the UPF0263 family
HHJ59_RS04505	COG4735	regulation of single-species biofilm formation
HHJ59_RS04540	COG2378	regulation of single-species biofilm formation
HHJ59_RS04555	COG1741	Belongs to the pirin family
HHJ59_RS04560	COG2951	lytic endotransglycosylase activity
HHJ59_RS04565	COG1216	Glycosyl transferase, family 2
HHJ59_RS04570	COG1216	Glycosyl transferase, family 2
HHJ59_RS04580	COG3306	glycosyltransferase involved in LPS biosynthesis
HHJ59_RS04590	COG5039	Polysaccharide pyruvyl transferase
HHJ59_RS04595	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HHJ59_RS04600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HHJ59_RS04605	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HHJ59_RS04605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HHJ59_RS04610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHJ59_RS04610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHJ59_RS04615	COG0489	protein tyrosine kinase activity
HHJ59_RS04620	COG0672	)-iron permease
HHJ59_RS04635	COG1136	(ABC) transporter
HHJ59_RS04635	COG0577	efflux transmembrane transporter activity
HHJ59_RS04645	COG1136	(ABC) transporter
HHJ59_RS04650	COG0676	glucose-6-phosphate 1-epimerase activity
HHJ59_RS04665	COG3177	Filamentation induced by cAMP protein fic
HHJ59_RS04675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HHJ59_RS04680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HHJ59_RS04685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HHJ59_RS04690	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHJ59_RS04690	COG2885	chlorophyll binding
HHJ59_RS04695	COG2824	Alkylphosphonate utilization operon protein PhnA
HHJ59_RS04700	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HHJ59_RS04705	COG1120	ATPase activity
HHJ59_RS04725	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
HHJ59_RS04730	COG4774	siderophore transport
HHJ59_RS04735	COG4774	siderophore transport
HHJ59_RS04745	COG0814	amino acid
HHJ59_RS04750	COG2964	Protein conserved in bacteria
HHJ59_RS04760	COG0469	pyruvate kinase activity
HHJ59_RS04765	COG0778	Nitroreductase
HHJ59_RS04775	COG0037	tRNA processing
HHJ59_RS04780	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HHJ59_RS04790	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHJ59_RS04795	COG0567	Dehydrogenase, E1 component
HHJ59_RS04800	COG0372	Belongs to the citrate synthase family
HHJ59_RS04805	COG3381	protein complex oligomerization
HHJ59_RS04810	COG2249	NAD(P)H dehydrogenase (quinone) activity
HHJ59_RS04820	COG0330	HflC and HflK could
HHJ59_RS04845	COG1940	carbohydrate kinase activity
HHJ59_RS04845	COG1846	Transcriptional regulator
HHJ59_RS04860	COG0497	DNA recombination
HHJ59_RS04865	COG0360	Binds together with S18 to 16S ribosomal RNA
HHJ59_RS04870	COG2965	DNA replication, synthesis of RNA primer
HHJ59_RS04895	COG1530	ribonuclease E activity
HHJ59_RS04955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HHJ59_RS04965	COG0024	Methionine aminopeptidase
HHJ59_RS04970	COG0316	Belongs to the HesB IscA family
HHJ59_RS04980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHJ59_RS04990	COG4166	transmembrane transport
HHJ59_RS04995	COG2832	Protein of unknown function (DUF454)
HHJ59_RS05000	COG0339	signal peptide processing
HHJ59_RS05005	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HHJ59_RS05010	COG1053	succinate dehydrogenase
HHJ59_RS05015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HHJ59_RS05025	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HHJ59_RS05035	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HHJ59_RS05040	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HHJ59_RS05045	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HHJ59_RS05060	COG1278	Cold shock
HHJ59_RS05065	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HHJ59_RS05075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HHJ59_RS05080	COG5007	Belongs to the BolA IbaG family
HHJ59_RS05085	COG3113	response to antibiotic
HHJ59_RS05090	COG2854	intermembrane phospholipid transfer
HHJ59_RS05095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HHJ59_RS05100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HHJ59_RS05105	COG1127	ABC transporter
HHJ59_RS05115	COG3117	lipopolysaccharide transmembrane transporter activity
HHJ59_RS05120	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HHJ59_RS05125	COG1137	ATPase activity
HHJ59_RS05130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ59_RS05145	COG2186	Transcriptional regulator
HHJ59_RS05160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HHJ59_RS05175	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ59_RS05225	COG2267	carboxylic ester hydrolase activity
HHJ59_RS05240	COG0436	Aminotransferase
HHJ59_RS05260	COG0861	Integral membrane protein TerC family
HHJ59_RS05270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HHJ59_RS05275	COG2067	long-chain fatty acid transport protein
HHJ59_RS05285	COG2860	membrane
HHJ59_RS05295	COG0527	aspartate kinase activity
HHJ59_RS05300	COG2897	thiosulfate sulfurtransferase activity
HHJ59_RS05305	COG2391	methyltransferase activity
HHJ59_RS05310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HHJ59_RS05325	COG3684	Belongs to the aldolase LacD family
HHJ59_RS05330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HHJ59_RS05335	COG1349	DNA-binding transcription factor activity
HHJ59_RS05345	COG3119	arylsulfatase activity
HHJ59_RS05350	COG0641	radical SAM
HHJ59_RS05360	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HHJ59_RS05365	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ59_RS05365	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ59_RS05370	COG3716	PTS system mannose fructose sorbose family IID component
HHJ59_RS05375	COG3715	PTS system
HHJ59_RS05380	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ59_RS05385	COG2222	sugar isomerase
HHJ59_RS05395	COG3119	arylsulfatase activity
HHJ59_RS05405	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ59_RS05415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHJ59_RS05420	COG0800	Aldolase
HHJ59_RS05425	COG0584	glycerophosphoryl diester phosphodiesterase
HHJ59_RS05430	COG3842	ATPase activity
HHJ59_RS05440	COG1177	transmembrane transport
HHJ59_RS05465	COG1509	lysine 2,3-aminomutase activity
HHJ59_RS05470	COG3266	domain, Protein
HHJ59_RS05470	COG3061	Opacity-associated protein A
HHJ59_RS05480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HHJ59_RS05485	COG2814	Major facilitator Superfamily
HHJ59_RS05490	COG4974	Belongs to the 'phage' integrase family
HHJ59_RS05495	COG0077	Prephenate dehydratase
HHJ59_RS05495	COG1605	Chorismate mutase
HHJ59_RS05500	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ59_RS05500	COG0604	alcohol dehydrogenase
HHJ59_RS05500	COG3321	synthase
HHJ59_RS05515	COG4221	oxidoreductase activity
HHJ59_RS05530	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HHJ59_RS05535	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HHJ59_RS05540	COG0849	cell division
HHJ59_RS05545	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HHJ59_RS05570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HHJ59_RS05580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HHJ59_RS05590	COG0768	penicillin binding
HHJ59_RS05595	COG3116	cell division
HHJ59_RS05615	COG1444	tRNA N-acetyltransferase activity
HHJ59_RS05625	COG1702	phosphate starvation-inducible protein PhoH
HHJ59_RS05635	COG0204	Acyl-transferase
HHJ59_RS05645	COG0121	glutamine amidotransferase
HHJ59_RS05650	COG0814	amino acid
HHJ59_RS05655	COG1760	l-serine dehydratase
HHJ59_RS05660	COG1138	Cytochrome C-type biogenesis protein
HHJ59_RS05670	COG3088	subunit of a heme lyase
HHJ59_RS05670	COG4235	cytochrome complex assembly
HHJ59_RS05675	COG4235	cytochrome complex assembly
HHJ59_RS05675	COG3088	subunit of a heme lyase
HHJ59_RS05680	COG2081	HI0933 family
HHJ59_RS05690	COG3301	Polysulphide reductase, NrfD
HHJ59_RS05695	COG0437	4 iron, 4 sulfur cluster binding
HHJ59_RS05700	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HHJ59_RS05705	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HHJ59_RS05725	COG1686	Belongs to the peptidase S11 family
HHJ59_RS05735	COG0772	Belongs to the SEDS family
HHJ59_RS05740	COG0768	penicillin binding
HHJ59_RS05750	COG0799	negative regulation of ribosome biogenesis
HHJ59_RS05755	COG0513	Belongs to the DEAD box helicase family
HHJ59_RS05760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HHJ59_RS05790	COG3842	ATPase activity
HHJ59_RS05830	COG1704	LemA family
HHJ59_RS05840	COG0277	FAD linked oxidase domain protein
HHJ59_RS05840	COG0247	lactate metabolic process
HHJ59_RS05855	COG3047	cAMP biosynthetic process
HHJ59_RS05870	COG1607	acyl-coa hydrolase
HHJ59_RS05875	COG2350	Protein conserved in bacteria
HHJ59_RS05895	COG1566	PFAM secretion protein HlyD family protein
HHJ59_RS05905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HHJ59_RS05910	COG0195	Participates in both transcription termination and antitermination
HHJ59_RS05925	COG0515	serine threonine protein kinase
HHJ59_RS05930	COG1115	amino acid carrier protein
HHJ59_RS05945	COG1940	carbohydrate kinase activity
HHJ59_RS05950	COG0671	phosphoesterase, PA-phosphatase related
HHJ59_RS05980	COG0307	riboflavin synthase, alpha
HHJ59_RS05990	COG0673	inositol 2-dehydrogenase activity
HHJ59_RS05995	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HHJ59_RS06000	COG0586	Pfam SNARE associated Golgi protein
HHJ59_RS06005	COG0322	excinuclease ABC activity
HHJ59_RS06010	COG1116	anion transmembrane transporter activity
HHJ59_RS06015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HHJ59_RS06020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HHJ59_RS06025	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HHJ59_RS06030	COG2835	tetraacyldisaccharide 4'-kinase activity
HHJ59_RS06035	COG1663	tetraacyldisaccharide 4'-kinase activity
HHJ59_RS06040	COG1132	(ABC) transporter
HHJ59_RS06045	COG0658	competence protein
HHJ59_RS06045	COG2333	competence protein COMEC
HHJ59_RS06055	COG0351	phosphomethylpyrimidine kinase
HHJ59_RS06060	COG0352	thiamine-phosphate diphosphorylase activity
HHJ59_RS06070	COG3468	outer membrane autotransporter barrel domain protein
HHJ59_RS06070	COG3266	domain, Protein
HHJ59_RS06075	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HHJ59_RS06080	COG3025	triphosphatase activity
HHJ59_RS06085	COG1392	Phosphate transport regulator
HHJ59_RS06090	COG0306	phosphate transporter
HHJ59_RS06095	COG0288	reversible hydration of carbon dioxide
HHJ59_RS06100	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HHJ59_RS06105	COG1448	Aminotransferase
HHJ59_RS06110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HHJ59_RS06115	COG3835	regulator
HHJ59_RS06120	COG2610	gluconate transmembrane transporter activity
HHJ59_RS06125	COG1929	Belongs to the glycerate kinase type-1 family
HHJ59_RS06150	COG0494	nUDIX hydrolase
HHJ59_RS06160	COG3041	Addiction module toxin RelE StbE family
HHJ59_RS06165	COG3077	Addiction module antitoxin, RelB DinJ family
HHJ59_RS06200	COG2932	Transcriptional regulator
HHJ59_RS06220	COG0305	Participates in initiation and elongation during chromosome replication
HHJ59_RS06225	COG3102	Protein conserved in bacteria
HHJ59_RS06235	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HHJ59_RS06240	COG4149	molybdate abc transporter
HHJ59_RS06245	COG0725	ABC transporter, periplasmic molybdate-binding protein
HHJ59_RS06250	COG2005	Transcriptional regulator
HHJ59_RS06255	COG0786	glutamate:sodium symporter activity
HHJ59_RS06270	COG0730	response to heat
HHJ59_RS06275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HHJ59_RS06285	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HHJ59_RS06290	COG1178	ABC-type Fe3 transport system permease component
HHJ59_RS06295	COG4143	(ABC) transporter
HHJ59_RS06300	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HHJ59_RS06310	COG3842	ATPase activity
HHJ59_RS06315	COG1176	ABC-type spermidine putrescine transport system, permease component I
HHJ59_RS06320	COG1177	transmembrane transport
HHJ59_RS06325	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HHJ59_RS06335	COG1733	regulation of RNA biosynthetic process
HHJ59_RS06340	COG0281	malic enzyme
HHJ59_RS06350	COG0673	inositol 2-dehydrogenase activity
HHJ59_RS06360	COG1175	transmembrane transport
HHJ59_RS06370	COG3842	ATPase activity
HHJ59_RS06375	COG2186	Transcriptional regulator
HHJ59_RS06380	COG0673	inositol 2-dehydrogenase activity
HHJ59_RS06385	COG1966	Carbon starvation protein
HHJ59_RS06390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HHJ59_RS06395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HHJ59_RS06400	COG1560	Kdo2-lipid A biosynthetic process
HHJ59_RS06405	COG0730	response to heat
HHJ59_RS06410	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HHJ59_RS06420	COG3264	Mechanosensitive ion channel
HHJ59_RS06420	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HHJ59_RS06425	COG0318	PFAM AMP-dependent synthetase and ligase
HHJ59_RS06430	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HHJ59_RS06435	COG0596	Alpha beta hydrolase
HHJ59_RS06445	COG0716	FMN binding
HHJ59_RS06450	COG0735	belongs to the Fur family
HHJ59_RS06460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HHJ59_RS06465	COG3094	Invasion gene expression up-regulator, SirB
HHJ59_RS06480	COG4221	oxidoreductase activity
HHJ59_RS06505	COG2814	Major facilitator Superfamily
HHJ59_RS06520	COG2249	NAD(P)H dehydrogenase (quinone) activity
HHJ59_RS06525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HHJ59_RS06530	COG0525	valine-tRNA ligase activity
HHJ59_RS06545	COG4185	zeta toxin
HHJ59_RS06555	COG2153	protein acetylation
HHJ59_RS06560	COG2927	DNA polymerase III (CHI subunit)
HHJ59_RS06570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HHJ59_RS06575	COG0512	Glutamine amidotransferase of anthranilate synthase
HHJ59_RS06580	COG1942	4-Oxalocrotonate Tautomerase
HHJ59_RS06585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HHJ59_RS06590	COG0135	phosphoribosylanthranilate isomerase activity
HHJ59_RS06590	COG0134	indole-3-glycerol-phosphate synthase activity
HHJ59_RS06605	COG3422	double-strand break repair
HHJ59_RS06615	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HHJ59_RS06615	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HHJ59_RS06620	COG0516	GMP reductase activity
HHJ59_RS06620	COG0517	IMP dehydrogenase activity
HHJ59_RS06635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HHJ59_RS06635	COG0519	Catalyzes the synthesis of GMP from XMP
HHJ59_RS06640	COG0582	viral genome integration into host DNA
HHJ59_RS06675	COG3646	Phage regulatory protein
HHJ59_RS06700	COG3179	chitinase
HHJ59_RS06885	COG1484	DNA-dependent DNA replication
HHJ59_RS06910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HHJ59_RS06995	COG2974	May be involved in recombination
HHJ59_RS07040	COG0270	DNA (cytosine-5-)-methyltransferase activity
HHJ59_RS07065	COG0251	oxidation-reduction process
HHJ59_RS07070	COG3021	interspecies interaction between organisms
HHJ59_RS07080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHJ59_RS07150	COG1982	Orn Lys Arg decarboxylase major
HHJ59_RS07155	COG0531	amino acid
HHJ59_RS07165	COG2217	Heavy metal translocating P-type atpase
HHJ59_RS07185	COG0437	4 iron, 4 sulfur cluster binding
HHJ59_RS07190	COG2864	formate dehydrogenase
HHJ59_RS07210	COG1687	branched-chain amino acid
HHJ59_RS07215	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HHJ59_RS07220	COG0583	DNA-binding transcription factor activity
HHJ59_RS07230	COG0471	metal ion transport
HHJ59_RS07240	COG1643	Atp-dependent helicase
HHJ59_RS07245	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HHJ59_RS07250	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HHJ59_RS07260	COG0484	heat shock protein binding
HHJ59_RS07270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHJ59_RS07280	COG0739	heme binding
HHJ59_RS07285	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HHJ59_RS07300	COG2850	peptidyl-arginine hydroxylation
HHJ59_RS07310	COG2867	negative regulation of translational initiation
HHJ59_RS07320	COG0012	GTP binding
HHJ59_RS07330	COG0531	amino acid
HHJ59_RS07335	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HHJ59_RS07345	COG3106	COG3106 Predicted ATPase
HHJ59_RS07350	COG4166	transmembrane transport
HHJ59_RS07355	COG4168	peptide transport system, permease
HHJ59_RS07360	COG4171	peptide transport system, permease
HHJ59_RS07365	COG4172	Belongs to the ABC transporter superfamily
HHJ59_RS07370	COG4172	Belongs to the ABC transporter superfamily
HHJ59_RS07375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HHJ59_RS07395	COG2259	Doxx family
HHJ59_RS07410	COG0151	Belongs to the GarS family
HHJ59_RS07415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HHJ59_RS07420	COG0745	RESPONSE REGULATOR receiver
HHJ59_RS07440	COG0023	Translation Initiation Factor
HHJ59_RS07450	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HHJ59_RS07455	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HHJ59_RS07460	COG0776	regulation of translation
HHJ59_RS07465	COG0539	negative regulation of cytoplasmic translation
HHJ59_RS07480	COG0612	Peptidase, M16
HHJ59_RS07485	COG2990	Protein conserved in bacteria
HHJ59_RS07495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHJ59_RS07530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHJ59_RS07535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HHJ59_RS07540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHJ59_RS07545	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HHJ59_RS07555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HHJ59_RS07560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HHJ59_RS07565	COG1454	alcohol dehydrogenase
HHJ59_RS07565	COG1012	belongs to the aldehyde dehydrogenase family
HHJ59_RS07580	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHJ59_RS07590	COG4178	(ABC) transporter
HHJ59_RS07600	COG5413	integral membrane protein
HHJ59_RS07605	COG4977	sequence-specific DNA binding
HHJ59_RS07605	COG1917	Cupin 2, conserved barrel domain protein
HHJ59_RS07610	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HHJ59_RS07615	COG1115	amino acid carrier protein
HHJ59_RS07625	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HHJ59_RS07625	COG0237	dephospho-CoA kinase activity
HHJ59_RS07635	COG1459	type II secretion system
HHJ59_RS07640	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ59_RS07640	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ59_RS07645	COG3715	PTS system
HHJ59_RS07650	COG3716	PTS system mannose fructose sorbose family IID component
HHJ59_RS07665	COG0328	RNA-DNA hybrid ribonuclease activity
HHJ59_RS07690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HHJ59_RS07695	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HHJ59_RS07700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHJ59_RS07720	COG0495	leucyl-tRNA aminoacylation
HHJ59_RS07725	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HHJ59_RS07730	COG1466	dna polymerase III delta subunit
HHJ59_RS07740	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HHJ59_RS07755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HHJ59_RS07760	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HHJ59_RS07765	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HHJ59_RS07775	COG0750	zinc metalloprotease
HHJ59_RS07780	COG0575	Belongs to the CDS family
HHJ59_RS07800	COG0528	UMP kinase activity
HHJ59_RS07805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HHJ59_RS07810	COG4969	Belongs to the N-Me-Phe pilin family
HHJ59_RS07815	COG3023	N-Acetylmuramoyl-L-alanine amidase
HHJ59_RS07825	COG0494	nUDIX hydrolase
HHJ59_RS07830	COG0730	response to heat
HHJ59_RS07845	COG0590	tRNA wobble adenosine to inosine editing
HHJ59_RS07850	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HHJ59_RS07855	COG0363	glucosamine-6-phosphate deaminase activity
HHJ59_RS07860	COG1793	dna ligase
HHJ59_RS07900	COG1215	transferase activity, transferring glycosyl groups
HHJ59_RS07930	COG0602	queuosine metabolic process
HHJ59_RS07935	COG0720	synthase
HHJ59_RS07940	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HHJ59_RS07945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HHJ59_RS08010	COG1598	PFAM Uncharacterised protein family UPF0150
HHJ59_RS08095	COG1783	phage Terminase large subunit
HHJ59_RS08100	COG3728	DNA packaging
HHJ59_RS08145	COG3617	BRO family, N-terminal domain
HHJ59_RS08230	COG3728	DNA packaging
HHJ59_RS08235	COG1783	phage Terminase large subunit
HHJ59_RS08240	COG3567	Phage-associated protein, HI1409 family
HHJ59_RS08245	COG2369	cell adhesion
HHJ59_RS08255	COG3566	protein conserved in bacteria
HHJ59_RS08410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HHJ59_RS08415	COG0165	Argininosuccinate lyase
HHJ59_RS08430	COG0642	Histidine kinase
HHJ59_RS08435	COG0745	RESPONSE REGULATOR receiver
HHJ59_RS08460	COG0196	riboflavin kinase activity
HHJ59_RS08475	COG0783	Belongs to the Dps family
HHJ59_RS08480	COG0512	Glutamine amidotransferase of anthranilate synthase
HHJ59_RS08490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HHJ59_RS08510	COG0251	oxidation-reduction process
HHJ59_RS08520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HHJ59_RS08525	COG0546	phosphoglycolate phosphatase activity
HHJ59_RS08535	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HHJ59_RS08545	COG0705	Rhomboid family
HHJ59_RS08550	COG1349	DNA-binding transcription factor activity
HHJ59_RS08555	COG0247	lactate metabolic process
HHJ59_RS08565	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HHJ59_RS08570	COG2271	Major facilitator Superfamily
HHJ59_RS08575	COG0584	glycerophosphoryl diester phosphodiesterase
HHJ59_RS08580	COG0552	protein localization to endoplasmic reticulum
HHJ59_RS08585	COG0742	ribosomal rna small subunit methyltransferase
HHJ59_RS08590	COG0758	DNA mediated transformation
HHJ59_RS08595	COG3063	Type IV pilus biogenesis stability protein PilW
HHJ59_RS08605	COG0628	permease
HHJ59_RS08615	COG0521	Mo-molybdopterin cofactor biosynthetic process
HHJ59_RS08620	COG4589	Belongs to the CDS family
HHJ59_RS08630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HHJ59_RS08635	COG0471	metal ion transport
HHJ59_RS08635	COG0490	domain, Protein
HHJ59_RS08640	COG1426	Protein conserved in bacteria
HHJ59_RS08645	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HHJ59_RS08655	COG2976	Protein conserved in bacteria
HHJ59_RS08660	COG3307	-O-antigen
HHJ59_RS08675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHJ59_RS08695	COG0312	modulator of DNA gyrase
HHJ59_RS08700	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HHJ59_RS08710	COG1271	oxidase subunit
HHJ59_RS08715	COG1294	oxidase, subunit
HHJ59_RS08725	COG3790	cyd operon protein YbgE
HHJ59_RS08735	COG0824	Thioesterase
HHJ59_RS08740	COG0811	peptide transport
HHJ59_RS08745	COG0848	biopolymer transport protein
HHJ59_RS08750	COG3064	Membrane
HHJ59_RS08770	COG2165	general secretion pathway protein
HHJ59_RS08775	COG4795	General secretion pathway protein
HHJ59_RS08790	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HHJ59_RS08795	COG0561	phosphatase activity
HHJ59_RS08800	COG0235	Class ii aldolase
HHJ59_RS08805	COG3623	hexulose-6-phosphate isomerase
HHJ59_RS08830	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HHJ59_RS08905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HHJ59_RS08920	COG2095	MarC family integral membrane protein
HHJ59_RS08925	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HHJ59_RS08930	COG1114	Component of the transport system for branched-chain amino acids
HHJ59_RS08935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HHJ59_RS08945	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HHJ59_RS08960	COG3956	TIGRFAM MazG family protein
HHJ59_RS08970	COG0583	DNA-binding transcription factor activity
HHJ59_RS08980	COG3119	arylsulfatase activity
HHJ59_RS08990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HHJ59_RS09025	COG0019	diaminopimelate decarboxylase activity
HHJ59_RS09060	COG2195	Cleaves the N-terminal amino acid of tripeptides
HHJ59_RS09080	COG3153	acetyltransferase
HHJ59_RS09095	COG1230	cation diffusion facilitator family transporter
HHJ59_RS09130	COG2271	Major facilitator Superfamily
HHJ59_RS09135	COG0483	inositol monophosphate 1-phosphatase activity
HHJ59_RS09145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HHJ59_RS09150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HHJ59_RS09160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HHJ59_RS09185	COG0357	Ribosomal RNA small subunit methyltransferase G
HHJ59_RS09195	COG0716	FMN binding
HHJ59_RS09205	COG1494	fructose-1,6-bisphosphatase
HHJ59_RS09210	COG0187	DNA topoisomerase II activity
HHJ59_RS09220	COG4988	ABC transporter
HHJ59_RS09225	COG1132	(ABC) transporter
HHJ59_RS09230	COG1858	cytochrome C peroxidase
HHJ59_RS09240	COG0733	neurotransmitter:sodium symporter activity
HHJ59_RS09255	COG0551	DNA topoisomerase type I activity
HHJ59_RS09275	COG3070	regulator of competence-specific genes
HHJ59_RS09315	COG2207	Transcriptional regulator
HHJ59_RS09315	COG1609	Transcriptional regulator
HHJ59_RS09320	COG1070	Carbohydrate kinase
HHJ59_RS09325	COG2115	Belongs to the xylose isomerase family
HHJ59_RS09330	COG0436	Aminotransferase
HHJ59_RS09335	COG1757	Na H antiporter
HHJ59_RS09340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HHJ59_RS09355	COG1349	DNA-binding transcription factor activity
HHJ59_RS09360	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ59_RS09365	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ59_RS09375	COG3732	PTS system glucitol sorbitol-specific
HHJ59_RS09390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HHJ59_RS09405	COG4214	carbohydrate transport
HHJ59_RS09410	COG1129	ABC transporter
HHJ59_RS09415	COG4213	ABC transporter substrate-binding protein
HHJ59_RS09420	COG1194	a g-specific adenine glycosylase
HHJ59_RS09425	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HHJ59_RS09445	COG0598	Magnesium transport protein CorA
HHJ59_RS09450	COG0762	integral membrane protein
HHJ59_RS09460	COG2177	Part of the ABC transporter FtsEX involved in
HHJ59_RS09465	COG2884	Cell division ATP-binding protein ftsE
HHJ59_RS09475	COG0235	Class ii aldolase
HHJ59_RS09480	COG3623	hexulose-6-phosphate isomerase
HHJ59_RS09490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HHJ59_RS09495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HHJ59_RS09500	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HHJ59_RS09505	COG2731	YhcH YjgK YiaL family protein
HHJ59_RS09510	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HHJ59_RS09515	COG1414	Transcriptional regulator
HHJ59_RS09525	COG1295	ribonuclease BN
HHJ59_RS09535	COG2197	response regulator
HHJ59_RS09545	COG0181	hydroxymethylbilane synthase activity
HHJ59_RS09555	COG2959	enzyme of heme biosynthesis
HHJ59_RS09560	COG3071	HemY protein
HHJ59_RS09565	COG3787	Belongs to the UPF0306 family
HHJ59_RS09570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HHJ59_RS09575	COG0076	glutamate decarboxylase activity
HHJ59_RS09580	COG0606	chelatase, subunit chli
HHJ59_RS09585	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HHJ59_RS09590	COG3171	Protein conserved in bacteria
HHJ59_RS09595	COG1921	L-seryl-tRNASec selenium transferase activity
HHJ59_RS09600	COG3276	selenocysteine insertion sequence binding
HHJ59_RS09610	COG1530	ribonuclease E activity
HHJ59_RS09620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HHJ59_RS09630	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HHJ59_RS09650	COG0511	ligase activity, forming carbon-carbon bonds
HHJ59_RS09655	COG0439	Biotin carboxylase
HHJ59_RS09660	COG3924	membrane
HHJ59_RS09665	COG4145	pantothenate transmembrane transporter activity
HHJ59_RS09685	COG0538	isocitrate dehydrogenase activity
HHJ59_RS09700	COG3477	response to acidic pH
HHJ59_RS09705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HHJ59_RS09710	COG2818	Glycosylase
HHJ59_RS09715	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HHJ59_RS09725	COG3021	interspecies interaction between organisms
HHJ59_RS09735	COG1522	sequence-specific DNA binding
HHJ59_RS09775	COG3978	acetolactate synthase activity
HHJ59_RS09785	COG0561	phosphatase activity
HHJ59_RS09790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HHJ59_RS09795	COG2267	carboxylic ester hydrolase activity
HHJ59_RS09800	COG1309	transcriptional regulator
HHJ59_RS09805	COG0583	DNA-binding transcription factor activity
HHJ59_RS09810	COG0678	peroxiredoxin activity
HHJ59_RS09810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HHJ59_RS09820	COG0545	Peptidyl-prolyl cis-trans isomerase
HHJ59_RS09825	COG2964	Protein conserved in bacteria
HHJ59_RS09835	COG2923	Belongs to the DsrF TusC family
HHJ59_RS09865	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HHJ59_RS09870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HHJ59_RS09895	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HHJ59_RS09900	COG0081	regulation of translation
HHJ59_RS09915	COG0085	RNA polymerase activity
HHJ59_RS09920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HHJ59_RS09925	COG1584	GPR1 FUN34 yaaH family protein
HHJ59_RS09930	COG0745	RESPONSE REGULATOR receiver
HHJ59_RS09935	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HHJ59_RS09950	COG3083	sulfuric ester hydrolase activity
HHJ59_RS09955	COG0402	S-adenosylhomocysteine deaminase activity
HHJ59_RS09965	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HHJ59_RS09970	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HHJ59_RS09975	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HHJ59_RS09980	COG1561	YicC-like family, N-terminal region
HHJ59_RS09985	COG0354	folic acid binding
HHJ59_RS09995	COG3084	Protein conserved in bacteria
HHJ59_RS10000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HHJ59_RS10005	COG3085	chromosome segregation
HHJ59_RS10010	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHJ59_RS10025	COG0560	Phosphoserine phosphatase
HHJ59_RS10035	COG0268	Binds directly to 16S ribosomal RNA
HHJ59_RS10040	COG0728	peptidoglycan biosynthetic process
HHJ59_RS10045	COG0729	surface antigen
HHJ59_RS10050	COG2911	Protein conserved in bacteria
HHJ59_RS10055	COG0248	Ppx GppA phosphatase
HHJ59_RS10060	COG0668	transmembrane transport
HHJ59_RS10065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HHJ59_RS10100	COG0433	COG0433 Predicted ATPase
HHJ59_RS10105	COG2990	Protein conserved in bacteria
HHJ59_RS10110	COG3676	manually curated
HHJ59_RS10115	COG0004	ammonium transporteR
HHJ59_RS10115	COG0004	ammonium transporteR
HHJ59_RS10140	COG2853	Lipoprotein
HHJ59_RS10150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HHJ59_RS10155	COG0513	Belongs to the DEAD box helicase family
HHJ59_RS10165	COG2837	iron assimilation
HHJ59_RS10180	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HHJ59_RS10185	COG1959	2 iron, 2 sulfur cluster binding
HHJ59_RS10195	COG0822	iron-sulfur transferase activity
HHJ59_RS10205	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HHJ59_RS10215	COG0443	Heat shock 70 kDa protein
HHJ59_RS10220	COG0633	Ferredoxin
HHJ59_RS10235	COG3716	PTS system mannose fructose sorbose family IID component
HHJ59_RS10240	COG3715	PTS system
HHJ59_RS10245	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ59_RS10245	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ59_RS10250	COG0561	phosphatase activity
HHJ59_RS10255	COG0463	Glycosyl transferase, family 2
HHJ59_RS10260	COG0859	PFAM glycosyl transferase family 9
HHJ59_RS10265	COG0228	four-way junction DNA binding
HHJ59_RS10270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HHJ59_RS10280	COG0335	large ribosomal subunit rRNA binding
HHJ59_RS10285	COG1368	sulfuric ester hydrolase activity
HHJ59_RS10295	COG0280	phosphate acetyltransferase
HHJ59_RS10295	COG0281	malic enzyme
HHJ59_RS10300	COG1187	pseudouridine synthase activity
HHJ59_RS10305	COG2814	Major facilitator Superfamily
HHJ59_RS10310	COG0789	Transcriptional regulator
HHJ59_RS10315	COG2194	sulfuric ester hydrolase activity
HHJ59_RS10320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HHJ59_RS10325	COG1045	serine acetyltransferase
HHJ59_RS10340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHJ59_RS10345	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HHJ59_RS10350	COG0778	Nitroreductase
HHJ59_RS10360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHJ59_RS10365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HHJ59_RS10370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HHJ59_RS10375	COG3719	Belongs to the RNase T2 family
HHJ59_RS10380	COG0126	phosphoglycerate kinase activity
HHJ59_RS10385	COG0191	fructose-bisphosphate aldolase activity
HHJ59_RS10395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHJ59_RS10400	COG1252	NADH dehydrogenase
HHJ59_RS10415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHJ59_RS10415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HHJ59_RS10420	COG0569	domain protein
HHJ59_RS10425	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HHJ59_RS10440	COG0513	Belongs to the DEAD box helicase family
HHJ59_RS10445	COG4785	May be involved in cell division
HHJ59_RS10455	COG3005	denitrification pathway
HHJ59_RS10460	COG3043	anaerobic respiration
HHJ59_RS10465	COG0348	domain, Protein
HHJ59_RS10470	COG0437	4 iron, 4 sulfur cluster binding
HHJ59_RS10475	COG0243	molybdopterin cofactor binding
HHJ59_RS10480	COG3062	negative regulation of establishment of protein localization
HHJ59_RS10485	COG3850	Histidine kinase
HHJ59_RS10500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HHJ59_RS10510	COG1040	competence protein
HHJ59_RS10515	COG2861	carbohydrate metabolic process
HHJ59_RS10520	COG4942	peptidase
HHJ59_RS10530	COG0425	Belongs to the sulfur carrier protein TusA family
HHJ59_RS10535	COG1739	Uncharacterized protein family UPF0029
HHJ59_RS10540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HHJ59_RS10545	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HHJ59_RS10600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HHJ59_RS10620	COG0201	protein transport
HHJ59_RS10630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HHJ59_RS10635	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HHJ59_RS10640	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HHJ59_RS10645	COG0202	RNA polymerase activity
HHJ59_RS10650	COG0203	ribosomal protein L17
HHJ59_RS10660	COG2960	long-chain fatty acid transporting porin activity
HHJ59_RS10665	COG3172	ATPase kinase involved in NAD metabolism
HHJ59_RS10670	COG2129	metallophosphoesterase
HHJ59_RS10680	COG0582	viral genome integration into host DNA
HHJ59_RS10760	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HHJ59_RS10780	COG0732	type I restriction modification DNA specificity domain
HHJ59_RS10785	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HHJ59_RS10790	COG3056	Lipoprotein
HHJ59_RS10795	COG0271	Belongs to the BolA IbaG family
HHJ59_RS10810	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HHJ59_RS10815	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HHJ59_RS10820	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HHJ59_RS10830	COG1477	protein flavinylation
HHJ59_RS10835	COG2991	Protein conserved in bacteria
HHJ59_RS10845	COG1519	Transferase
HHJ59_RS10855	COG0786	glutamate:sodium symporter activity
HHJ59_RS10885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HHJ59_RS10895	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HHJ59_RS10900	COG3068	Protein conserved in bacteria
HHJ59_RS10910	COG1349	DNA-binding transcription factor activity
HHJ59_RS10915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HHJ59_RS10930	COG0259	pyridoxamine-phosphate oxidase activity
HHJ59_RS10935	COG2814	Major facilitator Superfamily
HHJ59_RS10940	COG1763	Mo-molybdopterin cofactor biosynthetic process
HHJ59_RS10945	COG3086	response to oxidative stress
HHJ59_RS10950	COG3026	antisigma factor binding
HHJ59_RS10955	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HHJ59_RS10960	COG1595	DNA-templated transcription, initiation
HHJ59_RS10975	COG2226	methyltransferase
HHJ59_RS11000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HHJ59_RS11005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HHJ59_RS11010	COG0493	'glutamate synthase
HHJ59_RS11015	COG0067	glutamate synthase
HHJ59_RS11015	COG0070	glutamate synthase
HHJ59_RS11015	COG0069	glutamate synthase activity
HHJ59_RS11025	COG0859	PFAM glycosyl transferase family 9
HHJ59_RS11030	COG1132	(ABC) transporter
HHJ59_RS11040	COG0549	Belongs to the carbamate kinase family
HHJ59_RS11050	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HHJ59_RS11060	COG1304	FMN binding
HHJ59_RS11065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HHJ59_RS11075	COG0583	DNA-binding transcription factor activity
HHJ59_RS11085	COG1304	FMN binding
HHJ59_RS11090	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HHJ59_RS11095	COG0666	response to abiotic stimulus
HHJ59_RS11120	COG0675	Transposase, IS605 OrfB family
HHJ59_RS11130	COG1126	abc transporter atp-binding protein
HHJ59_RS11135	COG0765	amino acid transport
HHJ59_RS11140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHJ59_RS11145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HHJ59_RS11155	COG3078	GTPase activator activity
HHJ59_RS11160	COG0564	pseudouridine synthase activity
HHJ59_RS11170	COG3201	nicotinamide mononucleotide transporter
HHJ59_RS11175	COG0673	inositol 2-dehydrogenase activity
HHJ59_RS11180	COG3676	manually curated
HHJ59_RS11190	COG3718	enzyme involved in inositol metabolism
HHJ59_RS11205	COG0456	acetyltransferase
HHJ59_RS11235	COG0738	Major facilitator superfamily
HHJ59_RS11240	COG0235	Class ii aldolase
HHJ59_RS11250	COG1070	Carbohydrate kinase
HHJ59_RS11255	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
HHJ59_RS11260	COG1349	DNA-binding transcription factor activity
HHJ59_RS11270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHJ59_RS11285	COG0859	PFAM glycosyl transferase family 9
HHJ59_RS11325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HHJ59_RS11340	COG3691	Protein conserved in bacteria
HHJ59_RS11345	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HHJ59_RS11350	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HHJ59_RS11355	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HHJ59_RS11360	COG0363	glucosamine-6-phosphate deaminase activity
HHJ59_RS11365	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HHJ59_RS11370	COG1218	3'(2'),5'-bisphosphate nucleotidase
HHJ59_RS11375	COG1297	OPT oligopeptide transporter protein
HHJ59_RS11380	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HHJ59_RS11385	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HHJ59_RS11390	COG1609	Transcriptional regulator
HHJ59_RS11395	COG1917	Cupin 2, conserved barrel domain protein
HHJ59_RS11405	COG1070	Carbohydrate kinase
HHJ59_RS11410	COG1129	ABC transporter
HHJ59_RS11415	COG1172	Belongs to the binding-protein-dependent transport system permease family
HHJ59_RS11420	COG1879	ABC-type sugar transport system periplasmic component
HHJ59_RS11435	COG0051	transcription antitermination factor activity, RNA binding
HHJ59_RS11445	COG0088	Forms part of the polypeptide exit tunnel
HHJ59_RS11455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HHJ59_RS11460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HHJ59_RS11470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HHJ59_RS11495	COG0582	viral genome integration into host DNA
HHJ59_RS11585	COG3728	DNA packaging
HHJ59_RS11660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HHJ59_RS11665	COG0594	ribonuclease P activity