locus-tag	class	description
HHJ60_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HHJ60_RS00010	COG0592	DNA-directed DNA polymerase activity
HHJ60_RS00020	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HHJ60_RS00025	COG1381	Involved in DNA repair and RecF pathway recombination
HHJ60_RS00030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHJ60_RS00035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HHJ60_RS00040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HHJ60_RS00045	COG0252	asparaginase activity
HHJ60_RS00055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HHJ60_RS00075	COG3133	Outer membrane lipoprotein
HHJ60_RS00080	COG3962	Belongs to the TPP enzyme family
HHJ60_RS00090	COG0673	inositol 2-dehydrogenase activity
HHJ60_RS00100	COG0431	NADPH-dependent FMN reductase
HHJ60_RS00110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HHJ60_RS00120	COG3306	glycosyltransferase involved in LPS biosynthesis
HHJ60_RS00140	COG0174	glutamine synthetase
HHJ60_RS00165	COG4160	amino acid transport
HHJ60_RS00170	COG4215	(ABC) transporter
HHJ60_RS00175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHJ60_RS00180	COG1126	abc transporter atp-binding protein
HHJ60_RS00190	COG1393	Belongs to the ArsC family
HHJ60_RS00195	COG3036	rescue of stalled ribosome
HHJ60_RS00205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HHJ60_RS00210	COG4137	Cytochrome C assembly protein
HHJ60_RS00215	COG4536	flavin adenine dinucleotide binding
HHJ60_RS00220	COG0811	peptide transport
HHJ60_RS00225	COG0848	biopolymer transport protein
HHJ60_RS00240	COG0246	Mannitol dehydrogenase
HHJ60_RS00245	COG3722	fumarate hydratase activity
HHJ60_RS00255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHJ60_RS00255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHJ60_RS00260	COG3263	regulation of cellular component size
HHJ60_RS00265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HHJ60_RS00290	COG0740	serine-type endopeptidase activity
HHJ60_RS00300	COG1027	Aspartate ammonia-lyase
HHJ60_RS00305	COG1022	Amp-dependent synthetase and ligase
HHJ60_RS00310	COG0456	acetyltransferase
HHJ60_RS00315	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HHJ60_RS00335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHJ60_RS00340	COG1114	Component of the transport system for branched-chain amino acids
HHJ60_RS00345	COG2183	response to ionizing radiation
HHJ60_RS00370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHJ60_RS00375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HHJ60_RS00385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HHJ60_RS00390	COG1446	asparaginase
HHJ60_RS00395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HHJ60_RS00400	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HHJ60_RS00405	COG1447	Phosphotransferase system cellobiose-specific component IIA
HHJ60_RS00420	COG5645	(Lipo)protein
HHJ60_RS00425	COG0210	DNA helicase
HHJ60_RS00445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HHJ60_RS00485	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HHJ60_RS00490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HHJ60_RS00495	COG3091	SprT-like family
HHJ60_RS00500	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHJ60_RS00505	COG0326	Molecular chaperone. Has ATPase activity
HHJ60_RS00520	COG0330	HflC and HflK could
HHJ60_RS00525	COG0330	HflC and HflK could
HHJ60_RS00535	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HHJ60_RS00540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HHJ60_RS00550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HHJ60_RS00555	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HHJ60_RS00560	COG0470	DNA polymerase III
HHJ60_RS00565	COG0084	hydrolase, TatD family'
HHJ60_RS00575	COG1253	flavin adenine dinucleotide binding
HHJ60_RS00580	COG0254	rRNA binding
HHJ60_RS00585	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HHJ60_RS00590	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HHJ60_RS00605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHJ60_RS00620	COG0537	adenosine 5'-monophosphoramidase activity
HHJ60_RS00625	COG2116	formate transmembrane transporter activity
HHJ60_RS00630	COG1882	Formate acetyltransferase
HHJ60_RS00635	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HHJ60_RS00640	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HHJ60_RS00650	COG2017	converts alpha-aldose to the beta-anomer
HHJ60_RS00660	COG1085	galactose-1-phosphate uridylyltransferase
HHJ60_RS00665	COG1879	ABC-type sugar transport system periplasmic component
HHJ60_RS00670	COG1129	ABC transporter
HHJ60_RS00675	COG4211	Belongs to the binding-protein-dependent transport system permease family
HHJ60_RS00690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHJ60_RS00695	COG1138	Cytochrome C-type biogenesis protein
HHJ60_RS00705	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HHJ60_RS00710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HHJ60_RS00715	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HHJ60_RS00720	COG4133	protoheme IX ABC transporter activity
HHJ60_RS00735	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HHJ60_RS00740	COG0066	3-isopropylmalate dehydratase activity
HHJ60_RS00745	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HHJ60_RS00750	COG2233	PERMEase
HHJ60_RS00755	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HHJ60_RS00760	COG3161	chorismate lyase activity
HHJ60_RS00775	COG0107	imidazoleglycerol-phosphate synthase activity
HHJ60_RS00785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHJ60_RS00795	COG4804	nuclease activity
HHJ60_RS00800	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HHJ60_RS00800	COG0131	Imidazoleglycerol-phosphate dehydratase
HHJ60_RS00815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HHJ60_RS00820	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HHJ60_RS00825	COG2226	methyltransferase
HHJ60_RS00830	COG0814	amino acid
HHJ60_RS00840	COG4783	chaperone-mediated protein folding
HHJ60_RS00860	COG1238	metal cluster binding
HHJ60_RS00885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HHJ60_RS00890	COG0110	maltose O-acetyltransferase activity
HHJ60_RS00895	COG1238	metal cluster binding
HHJ60_RS00905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HHJ60_RS00910	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HHJ60_RS00915	COG1555	photosystem II stabilization
HHJ60_RS00920	COG2252	PERMEase
HHJ60_RS00930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HHJ60_RS00935	COG2814	Major facilitator Superfamily
HHJ60_RS00940	COG0385	Bile acid
HHJ60_RS00945	COG0784	Response regulator, receiver
HHJ60_RS00945	COG5002	protein histidine kinase activity
HHJ60_RS00945	COG2198	Histidine kinase
HHJ60_RS00965	COG0105	UTP biosynthetic process
HHJ60_RS01005	COG0681	Belongs to the peptidase S26 family
HHJ60_RS01025	COG0557	exoribonuclease II activity
HHJ60_RS01035	COG2814	Major facilitator Superfamily
HHJ60_RS01040	COG1566	PFAM secretion protein HlyD family protein
HHJ60_RS01045	COG1846	Transcriptional regulator
HHJ60_RS01060	COG1846	Transcriptional regulator
HHJ60_RS01070	COG2831	hemolysin activation secretion protein
HHJ60_RS01075	COG3210	domain, Protein
HHJ60_RS01075	COG3210	domain, Protein
HHJ60_RS01180	COG0697	spore germination
HHJ60_RS01195	COG0142	geranyltranstransferase activity
HHJ60_RS01200	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HHJ60_RS01210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHJ60_RS01215	COG0626	cystathionine gamma-synthase activity
HHJ60_RS01235	COG0582	viral genome integration into host DNA
HHJ60_RS01350	COG3657	addiction module killer protein
HHJ60_RS01355	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HHJ60_RS01370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HHJ60_RS01395	COG1846	Transcriptional regulator
HHJ60_RS01540	COG0629	single-stranded DNA binding
HHJ60_RS01565	COG3617	BRO family, N-terminal domain
HHJ60_RS01575	COG0582	viral genome integration into host DNA
HHJ60_RS01595	COG0752	glycyl-tRNA synthetase alpha subunit
HHJ60_RS01600	COG4545	Glutaredoxin-related protein
HHJ60_RS01610	COG4804	nuclease activity
HHJ60_RS01615	COG2852	Protein conserved in bacteria
HHJ60_RS01640	COG3676	manually curated
HHJ60_RS01645	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HHJ60_RS01650	COG4972	Pilus assembly protein
HHJ60_RS01670	COG4796	Type ii and iii secretion system protein
HHJ60_RS01680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HHJ60_RS01685	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HHJ60_RS01690	COG4701	Protein of unknown function (DUF721)
HHJ60_RS01700	COG0653	protein targeting
HHJ60_RS01705	COG0494	nUDIX hydrolase
HHJ60_RS01710	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HHJ60_RS01740	COG0582	viral genome integration into host DNA
HHJ60_RS01770	COG2026	Addiction module toxin, RelE StbE family
HHJ60_RS01830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HHJ60_RS01845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HHJ60_RS01850	COG1328	CTP reductase activity
HHJ60_RS01850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HHJ60_RS01855	COG0602	queuosine metabolic process
HHJ60_RS01860	COG0084	hydrolase, TatD family'
HHJ60_RS01870	COG0805	protein transport
HHJ60_RS01875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HHJ60_RS01885	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HHJ60_RS01895	COG2226	methyltransferase
HHJ60_RS01900	COG0471	metal ion transport
HHJ60_RS01905	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HHJ60_RS01910	COG1575	Belongs to the MenA family. Type 1 subfamily
HHJ60_RS01915	COG1720	tRNA m6t6A37 methyltransferase activity
HHJ60_RS01920	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HHJ60_RS01925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HHJ60_RS01930	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HHJ60_RS01935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HHJ60_RS01955	COG0006	proline dipeptidase activity
HHJ60_RS01960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHJ60_RS01965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHJ60_RS01970	COG1879	ABC-type sugar transport system periplasmic component
HHJ60_RS01980	COG1129	ABC transporter
HHJ60_RS01985	COG1172	Belongs to the binding-protein-dependent transport system permease family
HHJ60_RS02010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HHJ60_RS02030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HHJ60_RS02040	COG1737	Transcriptional regulator
HHJ60_RS02045	COG2731	YhcH YjgK YiaL family protein
HHJ60_RS02055	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HHJ60_RS02065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HHJ60_RS02085	COG4771	TonB-dependent receptor
HHJ60_RS02090	COG3721	Heme iron utilization protein
HHJ60_RS02095	COG0748	coenzyme F420 binding
HHJ60_RS02100	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HHJ60_RS02105	COG1792	Involved in formation and maintenance of cell shape
HHJ60_RS02110	COG1077	Cell shape determining protein MreB Mrl
HHJ60_RS02180	COG0656	L-ascorbic acid biosynthetic process
HHJ60_RS02190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HHJ60_RS02205	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ60_RS02210	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HHJ60_RS02215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HHJ60_RS02220	COG0416	fatty acid biosynthetic process
HHJ60_RS02230	COG1399	metal-binding, possibly nucleic acid-binding protein
HHJ60_RS02235	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HHJ60_RS02240	COG0500	methyltransferase
HHJ60_RS02245	COG2830	Protein of unknown function (DUF452)
HHJ60_RS02255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HHJ60_RS02275	COG0545	Peptidyl-prolyl cis-trans isomerase
HHJ60_RS02280	COG3676	manually curated
HHJ60_RS02285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HHJ60_RS02290	COG0194	GDP metabolic process
HHJ60_RS02300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HHJ60_RS02305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HHJ60_RS02340	COG4991	sh3 domain protein
HHJ60_RS02345	COG0617	tRNA 3'-terminal CCA addition
HHJ60_RS02350	COG3955	Domain of unknown function (DUF1919)
HHJ60_RS02355	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HHJ60_RS02360	COG1984	allophanate hydrolase subunit 2
HHJ60_RS02365	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HHJ60_RS02370	COG1914	H( )-stimulated, divalent metal cation uptake system
HHJ60_RS02385	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HHJ60_RS02395	COG0708	Exodeoxyribonuclease III
HHJ60_RS02410	COG0616	signal peptide processing
HHJ60_RS02415	COG1840	ABC-type Fe3 transport system, periplasmic component
HHJ60_RS02420	COG1408	metallophosphoesterase
HHJ60_RS02425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HHJ60_RS02430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HHJ60_RS02435	COG2863	cytochrome
HHJ60_RS02445	COG1199	ATP-dependent helicase activity
HHJ60_RS02450	COG1214	PFAM Peptidase M22, glycoprotease
HHJ60_RS02455	COG0318	PFAM AMP-dependent synthetase and ligase
HHJ60_RS02460	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HHJ60_RS02475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HHJ60_RS02480	COG4988	ABC transporter
HHJ60_RS02485	COG0492	ferredoxin-NADP+ reductase activity
HHJ60_RS02490	COG3118	belongs to the thioredoxin family
HHJ60_RS02495	COG2610	gluconate transmembrane transporter activity
HHJ60_RS02500	COG3265	gluconokinase activity
HHJ60_RS02510	COG0733	neurotransmitter:sodium symporter activity
HHJ60_RS02515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HHJ60_RS02530	COG4658	electron transport chain
HHJ60_RS02535	COG4656	Part of a membrane complex involved in electron transport
HHJ60_RS02545	COG4657	Part of a membrane complex involved in electron transport
HHJ60_RS02550	COG1090	epimerase
HHJ60_RS02555	COG1438	arginine binding
HHJ60_RS02560	COG0039	L-malate dehydrogenase activity
HHJ60_RS02570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HHJ60_RS02575	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HHJ60_RS02575	COG0517	IMP dehydrogenase activity
HHJ60_RS02605	COG0285	dihydrofolate synthase activity
HHJ60_RS02610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HHJ60_RS02615	COG3140	Belongs to the UPF0181 family
HHJ60_RS02620	COG1278	Cold shock
HHJ60_RS02635	COG1609	Transcriptional regulator
HHJ60_RS02650	COG1067	ATP-dependent peptidase activity
HHJ60_RS02660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HHJ60_RS02665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HHJ60_RS02670	COG2252	PERMEase
HHJ60_RS02675	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HHJ60_RS02680	COG1074	ATP-dependent DNA helicase activity
HHJ60_RS02685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HHJ60_RS02700	COG1940	carbohydrate kinase activity
HHJ60_RS02700	COG1846	Transcriptional regulator
HHJ60_RS02710	COG0788	formyltetrahydrofolate deformylase activity
HHJ60_RS02715	COG0406	alpha-ribazole phosphatase activity
HHJ60_RS02725	COG0564	pseudouridine synthase activity
HHJ60_RS02740	COG0776	regulation of translation
HHJ60_RS02745	COG0791	NLP P60 protein
HHJ60_RS02775	COG0697	spore germination
HHJ60_RS02780	COG2925	Exonuclease
HHJ60_RS02795	COG3676	manually curated
HHJ60_RS02800	COG2969	positive regulation of protein catabolic process
HHJ60_RS02825	COG3098	single-species biofilm formation
HHJ60_RS02830	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HHJ60_RS02845	COG1611	Belongs to the LOG family
HHJ60_RS02850	COG4453	Protein conserved in bacteria
HHJ60_RS02860	COG1215	transferase activity, transferring glycosyl groups
HHJ60_RS02865	COG0842	Transport permease protein
HHJ60_RS02870	COG1131	(ABC) transporter
HHJ60_RS02875	COG3101	peptidyl-lysine hydroxylation
HHJ60_RS02885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HHJ60_RS02905	COG1523	belongs to the glycosyl hydrolase 13 family
HHJ60_RS02910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HHJ60_RS02915	COG1640	4-alpha-glucanotransferase
HHJ60_RS02920	COG3152	Membrane
HHJ60_RS02935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHJ60_RS02940	COG1136	(ABC) transporter
HHJ60_RS02940	COG0577	efflux transmembrane transporter activity
HHJ60_RS02945	COG1538	Outer membrane efflux protein
HHJ60_RS02955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHJ60_RS02960	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHJ60_RS02965	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HHJ60_RS02970	COG2190	(PTS) system
HHJ60_RS02975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HHJ60_RS02980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ60_RS02985	COG1162	GTPase activity
HHJ60_RS02990	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HHJ60_RS03010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HHJ60_RS03015	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HHJ60_RS03040	COG1522	sequence-specific DNA binding
HHJ60_RS03050	COG1346	cytolysis
HHJ60_RS03055	COG1380	Effector of murein hydrolase LrgA
HHJ60_RS03060	COG1525	nuclease
HHJ60_RS03070	COG2166	iron-sulfur cluster assembly
HHJ60_RS03075	COG2268	Band 7 protein
HHJ60_RS03090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HHJ60_RS03095	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HHJ60_RS03095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HHJ60_RS03105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HHJ60_RS03110	COG0617	tRNA 3'-terminal CCA addition
HHJ60_RS03115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HHJ60_RS03120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHJ60_RS03120	COG0301	tRNA thio-modification
HHJ60_RS03130	COG0142	geranyltranstransferase activity
HHJ60_RS03140	COG1534	Rna-binding protein
HHJ60_RS03150	COG3217	Mosc domain protein beta barrel domain protein
HHJ60_RS03150	COG0633	Ferredoxin
HHJ60_RS03160	COG0287	Prephenate dehydrogenase
HHJ60_RS03160	COG1605	Chorismate mutase
HHJ60_RS03165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HHJ60_RS03170	COG0613	PHP domain protein
HHJ60_RS03175	COG0167	dihydroorotate dehydrogenase activity
HHJ60_RS03180	COG0308	aminopeptidase N
HHJ60_RS03185	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HHJ60_RS03230	COG0163	prenyltransferase activity
HHJ60_RS03240	COG1286	toxin biosynthetic process
HHJ60_RS03245	COG3092	negative regulation of chromosome organization
HHJ60_RS03255	COG0857	belongs to the CobB CobQ family
HHJ60_RS03255	COG0280	phosphate acetyltransferase
HHJ60_RS03280	COG0668	transmembrane transport
HHJ60_RS03285	COG0795	lipopolysaccharide-transporting ATPase activity
HHJ60_RS03290	COG0795	lipopolysaccharide-transporting ATPase activity
HHJ60_RS03315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHJ60_RS03320	COG2226	methyltransferase
HHJ60_RS03325	COG1944	ATP diphosphatase activity
HHJ60_RS03330	COG3105	Protein conserved in bacteria
HHJ60_RS03335	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HHJ60_RS03350	COG0633	Ferredoxin
HHJ60_RS03360	COG1280	lysine exporter protein (LysE YggA)
HHJ60_RS03365	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HHJ60_RS03370	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HHJ60_RS03375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHJ60_RS03385	COG0814	amino acid
HHJ60_RS03395	COG2062	phosphohistidine phosphatase, SixA
HHJ60_RS03405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HHJ60_RS03415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHJ60_RS03420	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHJ60_RS03420	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHJ60_RS03425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HHJ60_RS03465	COG2999	glutathione oxidoreductase activity
HHJ60_RS03500	COG1476	TRANSCRIPTIONal
HHJ60_RS03505	COG0582	viral genome integration into host DNA
HHJ60_RS03525	COG3306	glycosyltransferase involved in LPS biosynthesis
HHJ60_RS03530	COG3306	glycosyltransferase involved in LPS biosynthesis
HHJ60_RS03550	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HHJ60_RS03555	COG3683	transport system, periplasmic component
HHJ60_RS03560	COG0488	(ABC) transporter
HHJ60_RS03565	COG2195	Cleaves the N-terminal amino acid of tripeptides
HHJ60_RS03580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHJ60_RS03585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HHJ60_RS03590	COG1957	nucleoside hydrolase
HHJ60_RS03595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHJ60_RS03600	COG0670	Belongs to the BI1 family
HHJ60_RS03605	COG2920	part of a sulfur-relay system
HHJ60_RS03615	COG1121	(ABC) transporter
HHJ60_RS03620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHJ60_RS03625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHJ60_RS03630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HHJ60_RS03635	COG2949	membrane
HHJ60_RS03645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HHJ60_RS03650	COG4591	ABC-type transport system involved in lipoprotein release permease component
HHJ60_RS03655	COG1136	(ABC) transporter
HHJ60_RS03660	COG4591	ABC-type transport system involved in lipoprotein release permease component
HHJ60_RS03665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHJ60_RS03685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HHJ60_RS03695	COG1289	transmembrane transporter activity
HHJ60_RS03710	COG0314	molybdopterin synthase activity
HHJ60_RS03715	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HHJ60_RS03720	COG0315	cyclic pyranopterin monophosphate synthase activity
HHJ60_RS03765	COG1696	Membrane protein involved in D-alanine export
HHJ60_RS03775	COG0303	'Molybdopterin
HHJ60_RS03780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HHJ60_RS03785	COG2431	L-lysine efflux transmembrane transporter activity
HHJ60_RS03790	COG1528	Iron-storage protein
HHJ60_RS03795	COG1528	Iron-storage protein
HHJ60_RS03805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HHJ60_RS03810	COG0589	response to stress
HHJ60_RS03820	COG2171	N-acyltransferase activity
HHJ60_RS03825	COG0583	DNA-binding transcription factor activity
HHJ60_RS03835	COG0009	L-threonylcarbamoyladenylate synthase
HHJ60_RS03850	COG0792	nuclease activity
HHJ60_RS03855	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HHJ60_RS03860	COG2823	Periplasmic or secreted lipoprotein
HHJ60_RS03865	COG0210	DNA helicase
HHJ60_RS03885	COG0583	DNA-binding transcription factor activity
HHJ60_RS03890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HHJ60_RS03905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HHJ60_RS03910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HHJ60_RS03925	COG0626	cystathionine gamma-synthase activity
HHJ60_RS03930	COG0450	alkyl hydroperoxide reductase
HHJ60_RS03935	COG3100	YcgL domain-containing protein
HHJ60_RS03940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HHJ60_RS03940	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HHJ60_RS03945	COG1560	Kdo2-lipid A biosynthetic process
HHJ60_RS03950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHJ60_RS03955	COG3108	Peptidase M15
HHJ60_RS03960	COG2989	Protein conserved in bacteria
HHJ60_RS03965	COG0793	Belongs to the peptidase S41A family
HHJ60_RS03970	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HHJ60_RS03975	COG2995	paraquat-inducible protein a
HHJ60_RS03980	COG3008	intermembrane lipid transfer
HHJ60_RS03985	COG0187	DNA topoisomerase II activity
HHJ60_RS03995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HHJ60_RS04000	COG1328	CTP reductase activity
HHJ60_RS04005	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HHJ60_RS04030	COG0583	DNA-binding transcription factor activity
HHJ60_RS04035	COG0616	signal peptide processing
HHJ60_RS04040	COG0778	Nitroreductase
HHJ60_RS04060	COG0039	L-malate dehydrogenase activity
HHJ60_RS04065	COG0440	acetolactate synthase activity
HHJ60_RS04070	COG0028	Belongs to the TPP enzyme family
HHJ60_RS04075	COG1757	Na H antiporter
HHJ60_RS04090	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HHJ60_RS04115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHJ60_RS04140	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HHJ60_RS04145	COG0494	nUDIX hydrolase
HHJ60_RS04155	COG1876	peptidase activity
HHJ60_RS04160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHJ60_RS04165	COG1393	Belongs to the ArsC family
HHJ60_RS04185	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HHJ60_RS04190	COG0083	homoserine kinase activity
HHJ60_RS04195	COG0527	aspartate kinase activity
HHJ60_RS04195	COG0460	homoserine dehydrogenase
HHJ60_RS04210	COG0346	lactoylglutathione lyase activity
HHJ60_RS04215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HHJ60_RS04220	COG2056	Na+-H+ antiporter family
HHJ60_RS04225	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HHJ60_RS04225	COG0506	proline dehydrogenase activity
HHJ60_RS04225	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HHJ60_RS04230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HHJ60_RS04245	COG3945	hemerythrin HHE cation binding domain
HHJ60_RS04250	COG1862	Preprotein translocase
HHJ60_RS04255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHJ60_RS04260	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHJ60_RS04265	COG0741	lytic transglycosylase activity
HHJ60_RS04280	COG4221	oxidoreductase activity
HHJ60_RS04285	COG2814	Major facilitator Superfamily
HHJ60_RS04310	COG3210	domain, Protein
HHJ60_RS04335	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HHJ60_RS04345	COG0583	DNA-binding transcription factor activity
HHJ60_RS04350	COG0642	Histidine kinase
HHJ60_RS04355	COG0745	RESPONSE REGULATOR receiver
HHJ60_RS04360	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HHJ60_RS04370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HHJ60_RS04380	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HHJ60_RS04385	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HHJ60_RS04400	COG3119	arylsulfatase activity
HHJ60_RS04410	COG2089	acid synthase
HHJ60_RS04425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HHJ60_RS04435	COG1621	beta-fructofuranosidase activity
HHJ60_RS04450	COG0802	atpase or kinase
HHJ60_RS04455	COG1388	LysM domain
HHJ60_RS04455	COG0860	N-Acetylmuramoyl-L-alanine amidase
HHJ60_RS04460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HHJ60_RS04470	COG1923	regulation of RNA biosynthetic process
HHJ60_RS04475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HHJ60_RS04485	COG3099	Belongs to the UPF0263 family
HHJ60_RS04510	COG4735	regulation of single-species biofilm formation
HHJ60_RS04545	COG2378	regulation of single-species biofilm formation
HHJ60_RS04560	COG1741	Belongs to the pirin family
HHJ60_RS04565	COG2951	lytic endotransglycosylase activity
HHJ60_RS04570	COG1216	Glycosyl transferase, family 2
HHJ60_RS04575	COG1216	Glycosyl transferase, family 2
HHJ60_RS04585	COG3306	glycosyltransferase involved in LPS biosynthesis
HHJ60_RS04595	COG5039	Polysaccharide pyruvyl transferase
HHJ60_RS04600	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HHJ60_RS04605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HHJ60_RS04610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HHJ60_RS04610	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HHJ60_RS04615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHJ60_RS04615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHJ60_RS04620	COG0489	protein tyrosine kinase activity
HHJ60_RS04625	COG0672	)-iron permease
HHJ60_RS04640	COG0577	efflux transmembrane transporter activity
HHJ60_RS04640	COG1136	(ABC) transporter
HHJ60_RS04650	COG1136	(ABC) transporter
HHJ60_RS04655	COG0676	glucose-6-phosphate 1-epimerase activity
HHJ60_RS04670	COG3177	Filamentation induced by cAMP protein fic
HHJ60_RS04680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HHJ60_RS04685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HHJ60_RS04690	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HHJ60_RS04695	COG2885	chlorophyll binding
HHJ60_RS04695	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHJ60_RS04700	COG2824	Alkylphosphonate utilization operon protein PhnA
HHJ60_RS04705	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HHJ60_RS04710	COG1120	ATPase activity
HHJ60_RS04730	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
HHJ60_RS04735	COG4774	siderophore transport
HHJ60_RS04740	COG4774	siderophore transport
HHJ60_RS04750	COG0814	amino acid
HHJ60_RS04755	COG2964	Protein conserved in bacteria
HHJ60_RS04765	COG0469	pyruvate kinase activity
HHJ60_RS04770	COG0778	Nitroreductase
HHJ60_RS04780	COG0037	tRNA processing
HHJ60_RS04785	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HHJ60_RS04795	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHJ60_RS04800	COG0567	Dehydrogenase, E1 component
HHJ60_RS04805	COG0372	Belongs to the citrate synthase family
HHJ60_RS04810	COG3381	protein complex oligomerization
HHJ60_RS04815	COG2249	NAD(P)H dehydrogenase (quinone) activity
HHJ60_RS04825	COG0330	HflC and HflK could
HHJ60_RS04850	COG1940	carbohydrate kinase activity
HHJ60_RS04850	COG1846	Transcriptional regulator
HHJ60_RS04865	COG0497	DNA recombination
HHJ60_RS04870	COG0360	Binds together with S18 to 16S ribosomal RNA
HHJ60_RS04875	COG2965	DNA replication, synthesis of RNA primer
HHJ60_RS04900	COG1530	ribonuclease E activity
HHJ60_RS04960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HHJ60_RS04970	COG0024	Methionine aminopeptidase
HHJ60_RS04975	COG0316	Belongs to the HesB IscA family
HHJ60_RS04985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHJ60_RS04995	COG4166	transmembrane transport
HHJ60_RS05000	COG2832	Protein of unknown function (DUF454)
HHJ60_RS05005	COG0339	signal peptide processing
HHJ60_RS05010	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HHJ60_RS05015	COG1053	succinate dehydrogenase
HHJ60_RS05020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HHJ60_RS05030	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HHJ60_RS05040	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HHJ60_RS05045	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HHJ60_RS05050	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HHJ60_RS05065	COG1278	Cold shock
HHJ60_RS05070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HHJ60_RS05080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HHJ60_RS05085	COG5007	Belongs to the BolA IbaG family
HHJ60_RS05090	COG3113	response to antibiotic
HHJ60_RS05095	COG2854	intermembrane phospholipid transfer
HHJ60_RS05100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HHJ60_RS05105	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HHJ60_RS05110	COG1127	ABC transporter
HHJ60_RS05120	COG3117	lipopolysaccharide transmembrane transporter activity
HHJ60_RS05125	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HHJ60_RS05130	COG1137	ATPase activity
HHJ60_RS05135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ60_RS05150	COG2186	Transcriptional regulator
HHJ60_RS05165	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HHJ60_RS05180	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ60_RS05230	COG2267	carboxylic ester hydrolase activity
HHJ60_RS05245	COG0436	Aminotransferase
HHJ60_RS05265	COG0861	Integral membrane protein TerC family
HHJ60_RS05275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HHJ60_RS05280	COG2067	long-chain fatty acid transport protein
HHJ60_RS05295	COG2860	membrane
HHJ60_RS05305	COG0527	aspartate kinase activity
HHJ60_RS05310	COG2897	thiosulfate sulfurtransferase activity
HHJ60_RS05315	COG2391	methyltransferase activity
HHJ60_RS05320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HHJ60_RS05335	COG3684	Belongs to the aldolase LacD family
HHJ60_RS05340	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HHJ60_RS05345	COG1349	DNA-binding transcription factor activity
HHJ60_RS05355	COG3119	arylsulfatase activity
HHJ60_RS05360	COG0641	radical SAM
HHJ60_RS05370	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HHJ60_RS05375	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ60_RS05375	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ60_RS05380	COG3716	PTS system mannose fructose sorbose family IID component
HHJ60_RS05385	COG3715	PTS system
HHJ60_RS05390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ60_RS05395	COG2222	sugar isomerase
HHJ60_RS05405	COG3119	arylsulfatase activity
HHJ60_RS05415	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ60_RS05425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHJ60_RS05430	COG0800	Aldolase
HHJ60_RS05435	COG0584	glycerophosphoryl diester phosphodiesterase
HHJ60_RS05440	COG3842	ATPase activity
HHJ60_RS05450	COG1177	transmembrane transport
HHJ60_RS05475	COG1509	lysine 2,3-aminomutase activity
HHJ60_RS05480	COG3266	domain, Protein
HHJ60_RS05480	COG3061	Opacity-associated protein A
HHJ60_RS05490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HHJ60_RS05495	COG2814	Major facilitator Superfamily
HHJ60_RS05500	COG4974	Belongs to the 'phage' integrase family
HHJ60_RS05505	COG1605	Chorismate mutase
HHJ60_RS05505	COG0077	Prephenate dehydratase
HHJ60_RS05510	COG0604	alcohol dehydrogenase
HHJ60_RS05510	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ60_RS05510	COG3321	synthase
HHJ60_RS05525	COG4221	oxidoreductase activity
HHJ60_RS05540	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HHJ60_RS05545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HHJ60_RS05550	COG0849	cell division
HHJ60_RS05555	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HHJ60_RS05580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HHJ60_RS05590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HHJ60_RS05600	COG0768	penicillin binding
HHJ60_RS05605	COG3116	cell division
HHJ60_RS05625	COG1444	tRNA N-acetyltransferase activity
HHJ60_RS05635	COG1702	phosphate starvation-inducible protein PhoH
HHJ60_RS05645	COG0204	Acyl-transferase
HHJ60_RS05655	COG0121	glutamine amidotransferase
HHJ60_RS05660	COG0814	amino acid
HHJ60_RS05665	COG1760	l-serine dehydratase
HHJ60_RS05670	COG1138	Cytochrome C-type biogenesis protein
HHJ60_RS05680	COG4235	cytochrome complex assembly
HHJ60_RS05680	COG3088	subunit of a heme lyase
HHJ60_RS05685	COG3088	subunit of a heme lyase
HHJ60_RS05685	COG4235	cytochrome complex assembly
HHJ60_RS05690	COG2081	HI0933 family
HHJ60_RS05700	COG3301	Polysulphide reductase, NrfD
HHJ60_RS05705	COG0437	4 iron, 4 sulfur cluster binding
HHJ60_RS05710	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HHJ60_RS05715	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HHJ60_RS05735	COG1686	Belongs to the peptidase S11 family
HHJ60_RS05745	COG0772	Belongs to the SEDS family
HHJ60_RS05750	COG0768	penicillin binding
HHJ60_RS05760	COG0799	negative regulation of ribosome biogenesis
HHJ60_RS05765	COG0513	Belongs to the DEAD box helicase family
HHJ60_RS05770	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HHJ60_RS05800	COG3842	ATPase activity
HHJ60_RS05840	COG1704	LemA family
HHJ60_RS05850	COG0277	FAD linked oxidase domain protein
HHJ60_RS05850	COG0247	lactate metabolic process
HHJ60_RS05865	COG3047	cAMP biosynthetic process
HHJ60_RS05880	COG1607	acyl-coa hydrolase
HHJ60_RS05885	COG2350	Protein conserved in bacteria
HHJ60_RS05905	COG1566	PFAM secretion protein HlyD family protein
HHJ60_RS05915	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HHJ60_RS05920	COG0195	Participates in both transcription termination and antitermination
HHJ60_RS05935	COG0515	serine threonine protein kinase
HHJ60_RS05940	COG1115	amino acid carrier protein
HHJ60_RS05955	COG1940	carbohydrate kinase activity
HHJ60_RS05960	COG0671	phosphoesterase, PA-phosphatase related
HHJ60_RS05990	COG0307	riboflavin synthase, alpha
HHJ60_RS06000	COG0673	inositol 2-dehydrogenase activity
HHJ60_RS06005	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HHJ60_RS06010	COG0586	Pfam SNARE associated Golgi protein
HHJ60_RS06015	COG0322	excinuclease ABC activity
HHJ60_RS06020	COG1116	anion transmembrane transporter activity
HHJ60_RS06025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HHJ60_RS06030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HHJ60_RS06035	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HHJ60_RS06040	COG2835	tetraacyldisaccharide 4'-kinase activity
HHJ60_RS06045	COG1663	tetraacyldisaccharide 4'-kinase activity
HHJ60_RS06050	COG1132	(ABC) transporter
HHJ60_RS06055	COG2333	competence protein COMEC
HHJ60_RS06055	COG0658	competence protein
HHJ60_RS06065	COG0351	phosphomethylpyrimidine kinase
HHJ60_RS06070	COG0352	thiamine-phosphate diphosphorylase activity
HHJ60_RS06080	COG3468	outer membrane autotransporter barrel domain protein
HHJ60_RS06080	COG3266	domain, Protein
HHJ60_RS06085	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HHJ60_RS06090	COG3025	triphosphatase activity
HHJ60_RS06095	COG1392	Phosphate transport regulator
HHJ60_RS06100	COG0306	phosphate transporter
HHJ60_RS06105	COG0288	reversible hydration of carbon dioxide
HHJ60_RS06110	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HHJ60_RS06115	COG1448	Aminotransferase
HHJ60_RS06120	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HHJ60_RS06125	COG3835	regulator
HHJ60_RS06130	COG2610	gluconate transmembrane transporter activity
HHJ60_RS06135	COG1929	Belongs to the glycerate kinase type-1 family
HHJ60_RS06160	COG0494	nUDIX hydrolase
HHJ60_RS06170	COG3041	Addiction module toxin RelE StbE family
HHJ60_RS06175	COG3077	Addiction module antitoxin, RelB DinJ family
HHJ60_RS06210	COG2932	Transcriptional regulator
HHJ60_RS06230	COG0305	Participates in initiation and elongation during chromosome replication
HHJ60_RS06235	COG3102	Protein conserved in bacteria
HHJ60_RS06245	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HHJ60_RS06250	COG4149	molybdate abc transporter
HHJ60_RS06255	COG0725	ABC transporter, periplasmic molybdate-binding protein
HHJ60_RS06260	COG2005	Transcriptional regulator
HHJ60_RS06265	COG0786	glutamate:sodium symporter activity
HHJ60_RS06280	COG0730	response to heat
HHJ60_RS06285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HHJ60_RS06295	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HHJ60_RS06300	COG1178	ABC-type Fe3 transport system permease component
HHJ60_RS06305	COG4143	(ABC) transporter
HHJ60_RS06310	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HHJ60_RS06320	COG3842	ATPase activity
HHJ60_RS06325	COG1176	ABC-type spermidine putrescine transport system, permease component I
HHJ60_RS06330	COG1177	transmembrane transport
HHJ60_RS06335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HHJ60_RS06345	COG1733	regulation of RNA biosynthetic process
HHJ60_RS06350	COG0281	malic enzyme
HHJ60_RS06360	COG0673	inositol 2-dehydrogenase activity
HHJ60_RS06370	COG1175	transmembrane transport
HHJ60_RS06380	COG3842	ATPase activity
HHJ60_RS06385	COG2186	Transcriptional regulator
HHJ60_RS06390	COG0673	inositol 2-dehydrogenase activity
HHJ60_RS06395	COG1966	Carbon starvation protein
HHJ60_RS06400	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HHJ60_RS06405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HHJ60_RS06410	COG1560	Kdo2-lipid A biosynthetic process
HHJ60_RS06415	COG0730	response to heat
HHJ60_RS06420	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HHJ60_RS06430	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HHJ60_RS06430	COG3264	Mechanosensitive ion channel
HHJ60_RS06435	COG0318	PFAM AMP-dependent synthetase and ligase
HHJ60_RS06440	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HHJ60_RS06445	COG0596	Alpha beta hydrolase
HHJ60_RS06455	COG0716	FMN binding
HHJ60_RS06460	COG0735	belongs to the Fur family
HHJ60_RS06470	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HHJ60_RS06475	COG3094	Invasion gene expression up-regulator, SirB
HHJ60_RS06490	COG4221	oxidoreductase activity
HHJ60_RS06515	COG2814	Major facilitator Superfamily
HHJ60_RS06530	COG2249	NAD(P)H dehydrogenase (quinone) activity
HHJ60_RS06535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HHJ60_RS06540	COG0525	valine-tRNA ligase activity
HHJ60_RS06555	COG4185	zeta toxin
HHJ60_RS06565	COG2153	protein acetylation
HHJ60_RS06570	COG2927	DNA polymerase III (CHI subunit)
HHJ60_RS06580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HHJ60_RS06585	COG0512	Glutamine amidotransferase of anthranilate synthase
HHJ60_RS06590	COG1942	4-Oxalocrotonate Tautomerase
HHJ60_RS06595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HHJ60_RS06600	COG0135	phosphoribosylanthranilate isomerase activity
HHJ60_RS06600	COG0134	indole-3-glycerol-phosphate synthase activity
HHJ60_RS06615	COG3422	double-strand break repair
HHJ60_RS06625	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HHJ60_RS06625	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HHJ60_RS06630	COG0516	GMP reductase activity
HHJ60_RS06630	COG0517	IMP dehydrogenase activity
HHJ60_RS06645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HHJ60_RS06645	COG0519	Catalyzes the synthesis of GMP from XMP
HHJ60_RS06650	COG0582	viral genome integration into host DNA
HHJ60_RS06685	COG3646	Phage regulatory protein
HHJ60_RS06710	COG3179	chitinase
HHJ60_RS06895	COG1484	DNA-dependent DNA replication
HHJ60_RS06920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HHJ60_RS07005	COG2974	May be involved in recombination
HHJ60_RS07050	COG0270	DNA (cytosine-5-)-methyltransferase activity
HHJ60_RS07075	COG0251	oxidation-reduction process
HHJ60_RS07080	COG3021	interspecies interaction between organisms
HHJ60_RS07090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHJ60_RS07160	COG1982	Orn Lys Arg decarboxylase major
HHJ60_RS07165	COG0531	amino acid
HHJ60_RS07175	COG2217	Heavy metal translocating P-type atpase
HHJ60_RS07195	COG0437	4 iron, 4 sulfur cluster binding
HHJ60_RS07200	COG2864	formate dehydrogenase
HHJ60_RS07220	COG1687	branched-chain amino acid
HHJ60_RS07225	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HHJ60_RS07230	COG0583	DNA-binding transcription factor activity
HHJ60_RS07240	COG0471	metal ion transport
HHJ60_RS07250	COG1643	Atp-dependent helicase
HHJ60_RS07255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HHJ60_RS07260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HHJ60_RS07270	COG0484	heat shock protein binding
HHJ60_RS07280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHJ60_RS07290	COG0739	heme binding
HHJ60_RS07295	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HHJ60_RS07310	COG2850	peptidyl-arginine hydroxylation
HHJ60_RS07320	COG2867	negative regulation of translational initiation
HHJ60_RS07330	COG0012	GTP binding
HHJ60_RS07340	COG0531	amino acid
HHJ60_RS07345	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HHJ60_RS07355	COG3106	COG3106 Predicted ATPase
HHJ60_RS07360	COG4166	transmembrane transport
HHJ60_RS07365	COG4168	peptide transport system, permease
HHJ60_RS07370	COG4171	peptide transport system, permease
HHJ60_RS07375	COG4172	Belongs to the ABC transporter superfamily
HHJ60_RS07380	COG4172	Belongs to the ABC transporter superfamily
HHJ60_RS07385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HHJ60_RS07405	COG2259	Doxx family
HHJ60_RS07420	COG0151	Belongs to the GarS family
HHJ60_RS07425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HHJ60_RS07430	COG0745	RESPONSE REGULATOR receiver
HHJ60_RS07450	COG0023	Translation Initiation Factor
HHJ60_RS07460	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HHJ60_RS07465	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HHJ60_RS07470	COG0776	regulation of translation
HHJ60_RS07475	COG0539	negative regulation of cytoplasmic translation
HHJ60_RS07490	COG0612	Peptidase, M16
HHJ60_RS07495	COG2990	Protein conserved in bacteria
HHJ60_RS07505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHJ60_RS07540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHJ60_RS07545	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HHJ60_RS07550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHJ60_RS07555	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HHJ60_RS07565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HHJ60_RS07570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HHJ60_RS07575	COG1454	alcohol dehydrogenase
HHJ60_RS07575	COG1012	belongs to the aldehyde dehydrogenase family
HHJ60_RS07590	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHJ60_RS07600	COG4178	(ABC) transporter
HHJ60_RS07610	COG5413	integral membrane protein
HHJ60_RS07615	COG1917	Cupin 2, conserved barrel domain protein
HHJ60_RS07615	COG4977	sequence-specific DNA binding
HHJ60_RS07620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HHJ60_RS07625	COG1115	amino acid carrier protein
HHJ60_RS07635	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HHJ60_RS07635	COG0237	dephospho-CoA kinase activity
HHJ60_RS07645	COG1459	type II secretion system
HHJ60_RS07650	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ60_RS07650	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ60_RS07655	COG3715	PTS system
HHJ60_RS07660	COG3716	PTS system mannose fructose sorbose family IID component
HHJ60_RS07675	COG0328	RNA-DNA hybrid ribonuclease activity
HHJ60_RS07700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HHJ60_RS07705	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HHJ60_RS07710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHJ60_RS07730	COG0495	leucyl-tRNA aminoacylation
HHJ60_RS07735	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HHJ60_RS07740	COG1466	dna polymerase III delta subunit
HHJ60_RS07750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HHJ60_RS07765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HHJ60_RS07770	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HHJ60_RS07775	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HHJ60_RS07785	COG0750	zinc metalloprotease
HHJ60_RS07790	COG0575	Belongs to the CDS family
HHJ60_RS07810	COG0528	UMP kinase activity
HHJ60_RS07815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HHJ60_RS07820	COG4969	Belongs to the N-Me-Phe pilin family
HHJ60_RS07825	COG3023	N-Acetylmuramoyl-L-alanine amidase
HHJ60_RS07835	COG0494	nUDIX hydrolase
HHJ60_RS07840	COG0730	response to heat
HHJ60_RS07855	COG0590	tRNA wobble adenosine to inosine editing
HHJ60_RS07860	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HHJ60_RS07865	COG0363	glucosamine-6-phosphate deaminase activity
HHJ60_RS07870	COG1793	dna ligase
HHJ60_RS07910	COG1215	transferase activity, transferring glycosyl groups
HHJ60_RS07940	COG0602	queuosine metabolic process
HHJ60_RS07945	COG0720	synthase
HHJ60_RS07950	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HHJ60_RS07955	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HHJ60_RS08020	COG1598	PFAM Uncharacterised protein family UPF0150
HHJ60_RS08105	COG1783	phage Terminase large subunit
HHJ60_RS08110	COG3728	DNA packaging
HHJ60_RS08160	COG3617	BRO family, N-terminal domain
HHJ60_RS08245	COG3728	DNA packaging
HHJ60_RS08250	COG1783	phage Terminase large subunit
HHJ60_RS08255	COG3567	Phage-associated protein, HI1409 family
HHJ60_RS08260	COG2369	cell adhesion
HHJ60_RS08270	COG3566	protein conserved in bacteria
HHJ60_RS08425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HHJ60_RS08430	COG0165	Argininosuccinate lyase
HHJ60_RS08445	COG0642	Histidine kinase
HHJ60_RS08450	COG0745	RESPONSE REGULATOR receiver
HHJ60_RS08475	COG0196	riboflavin kinase activity
HHJ60_RS08490	COG0783	Belongs to the Dps family
HHJ60_RS08495	COG0512	Glutamine amidotransferase of anthranilate synthase
HHJ60_RS08505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HHJ60_RS08525	COG0251	oxidation-reduction process
HHJ60_RS08535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HHJ60_RS08540	COG0546	phosphoglycolate phosphatase activity
HHJ60_RS08550	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HHJ60_RS08560	COG0705	Rhomboid family
HHJ60_RS08565	COG1349	DNA-binding transcription factor activity
HHJ60_RS08570	COG0247	lactate metabolic process
HHJ60_RS08580	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HHJ60_RS08585	COG2271	Major facilitator Superfamily
HHJ60_RS08590	COG0584	glycerophosphoryl diester phosphodiesterase
HHJ60_RS08595	COG0552	protein localization to endoplasmic reticulum
HHJ60_RS08600	COG0742	ribosomal rna small subunit methyltransferase
HHJ60_RS08605	COG0758	DNA mediated transformation
HHJ60_RS08610	COG3063	Type IV pilus biogenesis stability protein PilW
HHJ60_RS08620	COG0628	permease
HHJ60_RS08630	COG0521	Mo-molybdopterin cofactor biosynthetic process
HHJ60_RS08635	COG4589	Belongs to the CDS family
HHJ60_RS08645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HHJ60_RS08650	COG0490	domain, Protein
HHJ60_RS08650	COG0471	metal ion transport
HHJ60_RS08655	COG1426	Protein conserved in bacteria
HHJ60_RS08660	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HHJ60_RS08670	COG2976	Protein conserved in bacteria
HHJ60_RS08675	COG3307	-O-antigen
HHJ60_RS08690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHJ60_RS08710	COG0312	modulator of DNA gyrase
HHJ60_RS08715	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HHJ60_RS08725	COG1271	oxidase subunit
HHJ60_RS08730	COG1294	oxidase, subunit
HHJ60_RS08740	COG3790	cyd operon protein YbgE
HHJ60_RS08750	COG0824	Thioesterase
HHJ60_RS08755	COG0811	peptide transport
HHJ60_RS08760	COG0848	biopolymer transport protein
HHJ60_RS08765	COG3064	Membrane
HHJ60_RS08790	COG2165	general secretion pathway protein
HHJ60_RS08795	COG4795	General secretion pathway protein
HHJ60_RS08810	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HHJ60_RS08815	COG0561	phosphatase activity
HHJ60_RS08820	COG0235	Class ii aldolase
HHJ60_RS08825	COG3623	hexulose-6-phosphate isomerase
HHJ60_RS08850	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HHJ60_RS08925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HHJ60_RS08940	COG2095	MarC family integral membrane protein
HHJ60_RS08945	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HHJ60_RS08950	COG1114	Component of the transport system for branched-chain amino acids
HHJ60_RS08955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HHJ60_RS08965	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HHJ60_RS08980	COG3956	TIGRFAM MazG family protein
HHJ60_RS08990	COG0583	DNA-binding transcription factor activity
HHJ60_RS09000	COG3119	arylsulfatase activity
HHJ60_RS09010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HHJ60_RS09045	COG0019	diaminopimelate decarboxylase activity
HHJ60_RS09080	COG2195	Cleaves the N-terminal amino acid of tripeptides
HHJ60_RS09100	COG3153	acetyltransferase
HHJ60_RS09115	COG1230	cation diffusion facilitator family transporter
HHJ60_RS09150	COG2271	Major facilitator Superfamily
HHJ60_RS09155	COG0483	inositol monophosphate 1-phosphatase activity
HHJ60_RS09165	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HHJ60_RS09170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HHJ60_RS09180	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HHJ60_RS09205	COG0357	Ribosomal RNA small subunit methyltransferase G
HHJ60_RS09215	COG0716	FMN binding
HHJ60_RS09225	COG1494	fructose-1,6-bisphosphatase
HHJ60_RS09230	COG0187	DNA topoisomerase II activity
HHJ60_RS09240	COG4988	ABC transporter
HHJ60_RS09245	COG1132	(ABC) transporter
HHJ60_RS09250	COG1858	cytochrome C peroxidase
HHJ60_RS09260	COG0733	neurotransmitter:sodium symporter activity
HHJ60_RS09275	COG0551	DNA topoisomerase type I activity
HHJ60_RS09295	COG3070	regulator of competence-specific genes
HHJ60_RS09335	COG1609	Transcriptional regulator
HHJ60_RS09335	COG2207	Transcriptional regulator
HHJ60_RS09340	COG1070	Carbohydrate kinase
HHJ60_RS09345	COG2115	Belongs to the xylose isomerase family
HHJ60_RS09350	COG0436	Aminotransferase
HHJ60_RS09355	COG1757	Na H antiporter
HHJ60_RS09360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HHJ60_RS09375	COG1349	DNA-binding transcription factor activity
HHJ60_RS09380	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ60_RS09385	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ60_RS09395	COG3732	PTS system glucitol sorbitol-specific
HHJ60_RS09410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HHJ60_RS09425	COG4214	carbohydrate transport
HHJ60_RS09430	COG1129	ABC transporter
HHJ60_RS09435	COG4213	ABC transporter substrate-binding protein
HHJ60_RS09440	COG1194	a g-specific adenine glycosylase
HHJ60_RS09445	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HHJ60_RS09465	COG0598	Magnesium transport protein CorA
HHJ60_RS09470	COG0762	integral membrane protein
HHJ60_RS09480	COG2177	Part of the ABC transporter FtsEX involved in
HHJ60_RS09485	COG2884	Cell division ATP-binding protein ftsE
HHJ60_RS09495	COG0235	Class ii aldolase
HHJ60_RS09500	COG3623	hexulose-6-phosphate isomerase
HHJ60_RS09510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HHJ60_RS09515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HHJ60_RS09520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HHJ60_RS09525	COG2731	YhcH YjgK YiaL family protein
HHJ60_RS09530	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HHJ60_RS09535	COG1414	Transcriptional regulator
HHJ60_RS09545	COG1295	ribonuclease BN
HHJ60_RS09555	COG2197	response regulator
HHJ60_RS09565	COG0181	hydroxymethylbilane synthase activity
HHJ60_RS09575	COG2959	enzyme of heme biosynthesis
HHJ60_RS09580	COG3071	HemY protein
HHJ60_RS09585	COG3787	Belongs to the UPF0306 family
HHJ60_RS09590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HHJ60_RS09595	COG0076	glutamate decarboxylase activity
HHJ60_RS09600	COG0606	chelatase, subunit chli
HHJ60_RS09605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HHJ60_RS09610	COG3171	Protein conserved in bacteria
HHJ60_RS09615	COG1921	L-seryl-tRNASec selenium transferase activity
HHJ60_RS09620	COG3276	selenocysteine insertion sequence binding
HHJ60_RS09630	COG1530	ribonuclease E activity
HHJ60_RS09640	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HHJ60_RS09650	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HHJ60_RS09670	COG0511	ligase activity, forming carbon-carbon bonds
HHJ60_RS09675	COG0439	Biotin carboxylase
HHJ60_RS09680	COG3924	membrane
HHJ60_RS09685	COG4145	pantothenate transmembrane transporter activity
HHJ60_RS09705	COG0538	isocitrate dehydrogenase activity
HHJ60_RS09720	COG3477	response to acidic pH
HHJ60_RS09725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HHJ60_RS09730	COG2818	Glycosylase
HHJ60_RS09735	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HHJ60_RS09745	COG3021	interspecies interaction between organisms
HHJ60_RS09755	COG1522	sequence-specific DNA binding
HHJ60_RS09795	COG3978	acetolactate synthase activity
HHJ60_RS09805	COG0561	phosphatase activity
HHJ60_RS09810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HHJ60_RS09815	COG2267	carboxylic ester hydrolase activity
HHJ60_RS09820	COG1309	transcriptional regulator
HHJ60_RS09825	COG0583	DNA-binding transcription factor activity
HHJ60_RS09830	COG0678	peroxiredoxin activity
HHJ60_RS09830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HHJ60_RS09840	COG0545	Peptidyl-prolyl cis-trans isomerase
HHJ60_RS09845	COG2964	Protein conserved in bacteria
HHJ60_RS09855	COG2923	Belongs to the DsrF TusC family
HHJ60_RS09885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HHJ60_RS09890	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HHJ60_RS09915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HHJ60_RS09920	COG0081	regulation of translation
HHJ60_RS09935	COG0085	RNA polymerase activity
HHJ60_RS09940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HHJ60_RS09945	COG1584	GPR1 FUN34 yaaH family protein
HHJ60_RS09950	COG0745	RESPONSE REGULATOR receiver
HHJ60_RS09955	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HHJ60_RS09970	COG3083	sulfuric ester hydrolase activity
HHJ60_RS09975	COG0402	S-adenosylhomocysteine deaminase activity
HHJ60_RS09985	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HHJ60_RS09990	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HHJ60_RS09995	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HHJ60_RS10000	COG1561	YicC-like family, N-terminal region
HHJ60_RS10005	COG0354	folic acid binding
HHJ60_RS10015	COG3084	Protein conserved in bacteria
HHJ60_RS10020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HHJ60_RS10025	COG3085	chromosome segregation
HHJ60_RS10030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHJ60_RS10045	COG0560	Phosphoserine phosphatase
HHJ60_RS10055	COG0268	Binds directly to 16S ribosomal RNA
HHJ60_RS10060	COG0728	peptidoglycan biosynthetic process
HHJ60_RS10065	COG0729	surface antigen
HHJ60_RS10070	COG2911	Protein conserved in bacteria
HHJ60_RS10075	COG0248	Ppx GppA phosphatase
HHJ60_RS10080	COG0668	transmembrane transport
HHJ60_RS10085	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HHJ60_RS10120	COG0433	COG0433 Predicted ATPase
HHJ60_RS10125	COG2990	Protein conserved in bacteria
HHJ60_RS10130	COG3676	manually curated
HHJ60_RS10135	COG0004	ammonium transporteR
HHJ60_RS10135	COG0004	ammonium transporteR
HHJ60_RS10160	COG2853	Lipoprotein
HHJ60_RS10170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HHJ60_RS10175	COG0513	Belongs to the DEAD box helicase family
HHJ60_RS10185	COG2837	iron assimilation
HHJ60_RS10200	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HHJ60_RS10205	COG1959	2 iron, 2 sulfur cluster binding
HHJ60_RS10215	COG0822	iron-sulfur transferase activity
HHJ60_RS10225	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HHJ60_RS10235	COG0443	Heat shock 70 kDa protein
HHJ60_RS10240	COG0633	Ferredoxin
HHJ60_RS10255	COG3716	PTS system mannose fructose sorbose family IID component
HHJ60_RS10260	COG3715	PTS system
HHJ60_RS10265	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ60_RS10265	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ60_RS10270	COG0561	phosphatase activity
HHJ60_RS10275	COG0463	Glycosyl transferase, family 2
HHJ60_RS10280	COG0859	PFAM glycosyl transferase family 9
HHJ60_RS10285	COG0228	four-way junction DNA binding
HHJ60_RS10290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HHJ60_RS10300	COG0335	large ribosomal subunit rRNA binding
HHJ60_RS10305	COG1368	sulfuric ester hydrolase activity
HHJ60_RS10315	COG0280	phosphate acetyltransferase
HHJ60_RS10315	COG0281	malic enzyme
HHJ60_RS10320	COG1187	pseudouridine synthase activity
HHJ60_RS10325	COG2814	Major facilitator Superfamily
HHJ60_RS10330	COG0789	Transcriptional regulator
HHJ60_RS10335	COG2194	sulfuric ester hydrolase activity
HHJ60_RS10340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HHJ60_RS10345	COG1045	serine acetyltransferase
HHJ60_RS10360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHJ60_RS10365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HHJ60_RS10370	COG0778	Nitroreductase
HHJ60_RS10380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHJ60_RS10385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HHJ60_RS10390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HHJ60_RS10395	COG3719	Belongs to the RNase T2 family
HHJ60_RS10400	COG0126	phosphoglycerate kinase activity
HHJ60_RS10405	COG0191	fructose-bisphosphate aldolase activity
HHJ60_RS10415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHJ60_RS10420	COG1252	NADH dehydrogenase
HHJ60_RS10435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHJ60_RS10435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HHJ60_RS10440	COG0569	domain protein
HHJ60_RS10445	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HHJ60_RS10460	COG0513	Belongs to the DEAD box helicase family
HHJ60_RS10465	COG4785	May be involved in cell division
HHJ60_RS10475	COG3005	denitrification pathway
HHJ60_RS10480	COG3043	anaerobic respiration
HHJ60_RS10485	COG0348	domain, Protein
HHJ60_RS10490	COG0437	4 iron, 4 sulfur cluster binding
HHJ60_RS10495	COG0243	molybdopterin cofactor binding
HHJ60_RS10500	COG3062	negative regulation of establishment of protein localization
HHJ60_RS10505	COG3850	Histidine kinase
HHJ60_RS10520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HHJ60_RS10530	COG1040	competence protein
HHJ60_RS10535	COG2861	carbohydrate metabolic process
HHJ60_RS10540	COG4942	peptidase
HHJ60_RS10550	COG0425	Belongs to the sulfur carrier protein TusA family
HHJ60_RS10555	COG1739	Uncharacterized protein family UPF0029
HHJ60_RS10560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HHJ60_RS10565	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HHJ60_RS10620	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HHJ60_RS10640	COG0201	protein transport
HHJ60_RS10650	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HHJ60_RS10655	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HHJ60_RS10660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HHJ60_RS10665	COG0202	RNA polymerase activity
HHJ60_RS10670	COG0203	ribosomal protein L17
HHJ60_RS10680	COG2960	long-chain fatty acid transporting porin activity
HHJ60_RS10685	COG3172	ATPase kinase involved in NAD metabolism
HHJ60_RS10690	COG2129	metallophosphoesterase
HHJ60_RS10700	COG0582	viral genome integration into host DNA
HHJ60_RS10780	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HHJ60_RS10795	COG0732	type I restriction modification DNA specificity domain
HHJ60_RS10805	COG3056	Lipoprotein
HHJ60_RS10810	COG0271	Belongs to the BolA IbaG family
HHJ60_RS10825	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HHJ60_RS10830	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HHJ60_RS10835	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HHJ60_RS10845	COG1477	protein flavinylation
HHJ60_RS10850	COG2991	Protein conserved in bacteria
HHJ60_RS10860	COG1519	Transferase
HHJ60_RS10870	COG0786	glutamate:sodium symporter activity
HHJ60_RS10900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HHJ60_RS10910	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HHJ60_RS10915	COG3068	Protein conserved in bacteria
HHJ60_RS10925	COG1349	DNA-binding transcription factor activity
HHJ60_RS10930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HHJ60_RS10945	COG0259	pyridoxamine-phosphate oxidase activity
HHJ60_RS10950	COG2814	Major facilitator Superfamily
HHJ60_RS10955	COG1763	Mo-molybdopterin cofactor biosynthetic process
HHJ60_RS10960	COG3086	response to oxidative stress
HHJ60_RS10965	COG3026	antisigma factor binding
HHJ60_RS10970	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HHJ60_RS10975	COG1595	DNA-templated transcription, initiation
HHJ60_RS10990	COG2226	methyltransferase
HHJ60_RS11015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HHJ60_RS11020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HHJ60_RS11025	COG0493	'glutamate synthase
HHJ60_RS11030	COG0070	glutamate synthase
HHJ60_RS11030	COG0069	glutamate synthase activity
HHJ60_RS11030	COG0067	glutamate synthase
HHJ60_RS11040	COG0859	PFAM glycosyl transferase family 9
HHJ60_RS11045	COG1132	(ABC) transporter
HHJ60_RS11055	COG0549	Belongs to the carbamate kinase family
HHJ60_RS11065	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HHJ60_RS11075	COG1304	FMN binding
HHJ60_RS11080	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HHJ60_RS11090	COG0583	DNA-binding transcription factor activity
HHJ60_RS11100	COG1304	FMN binding
HHJ60_RS11105	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HHJ60_RS11110	COG0666	response to abiotic stimulus
HHJ60_RS11135	COG0675	Transposase, IS605 OrfB family
HHJ60_RS11145	COG1126	abc transporter atp-binding protein
HHJ60_RS11150	COG0765	amino acid transport
HHJ60_RS11155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHJ60_RS11160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HHJ60_RS11170	COG3078	GTPase activator activity
HHJ60_RS11175	COG0564	pseudouridine synthase activity
HHJ60_RS11185	COG3201	nicotinamide mononucleotide transporter
HHJ60_RS11190	COG0673	inositol 2-dehydrogenase activity
HHJ60_RS11195	COG3676	manually curated
HHJ60_RS11205	COG3718	enzyme involved in inositol metabolism
HHJ60_RS11220	COG0456	acetyltransferase
HHJ60_RS11250	COG0738	Major facilitator superfamily
HHJ60_RS11255	COG0235	Class ii aldolase
HHJ60_RS11265	COG1070	Carbohydrate kinase
HHJ60_RS11270	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
HHJ60_RS11275	COG1349	DNA-binding transcription factor activity
HHJ60_RS11285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHJ60_RS11300	COG0859	PFAM glycosyl transferase family 9
HHJ60_RS11340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HHJ60_RS11355	COG3691	Protein conserved in bacteria
HHJ60_RS11360	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HHJ60_RS11365	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HHJ60_RS11370	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HHJ60_RS11375	COG0363	glucosamine-6-phosphate deaminase activity
HHJ60_RS11380	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HHJ60_RS11385	COG1218	3'(2'),5'-bisphosphate nucleotidase
HHJ60_RS11390	COG1297	OPT oligopeptide transporter protein
HHJ60_RS11395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HHJ60_RS11400	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HHJ60_RS11405	COG1609	Transcriptional regulator
HHJ60_RS11410	COG1917	Cupin 2, conserved barrel domain protein
HHJ60_RS11420	COG1070	Carbohydrate kinase
HHJ60_RS11425	COG1129	ABC transporter
HHJ60_RS11430	COG1172	Belongs to the binding-protein-dependent transport system permease family
HHJ60_RS11435	COG1879	ABC-type sugar transport system periplasmic component
HHJ60_RS11450	COG0051	transcription antitermination factor activity, RNA binding
HHJ60_RS11460	COG0088	Forms part of the polypeptide exit tunnel
HHJ60_RS11470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HHJ60_RS11475	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HHJ60_RS11485	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HHJ60_RS11510	COG0582	viral genome integration into host DNA
HHJ60_RS11600	COG3728	DNA packaging
HHJ60_RS11675	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HHJ60_RS11680	COG0594	ribonuclease P activity