locus-tag	class	description
VY92_RS00010	COG0594	ribonuclease P activity
VY92_RS00020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VY92_RS00025	COG0592	DNA-directed DNA polymerase activity
VY92_RS00035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VY92_RS00040	COG1381	Involved in DNA repair and RecF pathway recombination
VY92_RS00045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VY92_RS00050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VY92_RS00055	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VY92_RS00060	COG0252	asparaginase activity
VY92_RS00070	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VY92_RS00090	COG3133	Outer membrane lipoprotein
VY92_RS00095	COG3962	Belongs to the TPP enzyme family
VY92_RS00105	COG0673	inositol 2-dehydrogenase activity
VY92_RS00115	COG0431	NADPH-dependent FMN reductase
VY92_RS00125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VY92_RS00130	COG1216	Glycosyl transferase, family 2
VY92_RS00135	COG3307	-O-antigen
VY92_RS00140	COG2976	Protein conserved in bacteria
VY92_RS00150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VY92_RS00155	COG1426	Protein conserved in bacteria
VY92_RS00160	COG0490	domain, Protein
VY92_RS00160	COG0471	metal ion transport
VY92_RS00165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VY92_RS00175	COG4589	Belongs to the CDS family
VY92_RS00180	COG0521	Mo-molybdopterin cofactor biosynthetic process
VY92_RS00190	COG0628	permease
VY92_RS00200	COG3063	Type IV pilus biogenesis stability protein PilW
VY92_RS00205	COG0758	DNA mediated transformation
VY92_RS00210	COG0742	ribosomal rna small subunit methyltransferase
VY92_RS00215	COG0552	protein localization to endoplasmic reticulum
VY92_RS00220	COG0584	glycerophosphoryl diester phosphodiesterase
VY92_RS00225	COG2271	Major facilitator Superfamily
VY92_RS00230	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VY92_RS00240	COG0247	lactate metabolic process
VY92_RS00245	COG1349	DNA-binding transcription factor activity
VY92_RS00250	COG0705	Rhomboid family
VY92_RS00260	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VY92_RS00270	COG0546	phosphoglycolate phosphatase activity
VY92_RS00275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VY92_RS00285	COG0251	oxidation-reduction process
VY92_RS00305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VY92_RS00315	COG0512	Glutamine amidotransferase of anthranilate synthase
VY92_RS00320	COG0783	Belongs to the Dps family
VY92_RS00335	COG0196	riboflavin kinase activity
VY92_RS00360	COG0745	RESPONSE REGULATOR receiver
VY92_RS00365	COG0642	Histidine kinase
VY92_RS00380	COG0165	Argininosuccinate lyase
VY92_RS00385	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VY92_RS00545	COG3566	protein conserved in bacteria
VY92_RS00555	COG2369	cell adhesion
VY92_RS00560	COG3567	Phage-associated protein, HI1409 family
VY92_RS00565	COG1783	phage Terminase large subunit
VY92_RS00570	COG3728	DNA packaging
VY92_RS00620	COG3617	BRO family, N-terminal domain
VY92_RS00635	COG1846	Transcriptional regulator
VY92_RS00660	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VY92_RS00730	COG3617	BRO family, N-terminal domain
VY92_RS00745	COG1846	Transcriptional regulator
VY92_RS00810	COG3728	DNA packaging
VY92_RS00815	COG1783	phage Terminase large subunit
VY92_RS00900	COG1598	PFAM Uncharacterised protein family UPF0150
VY92_RS01095	COG4695	Portal protein
VY92_RS01170	COG4974	Belongs to the 'phage' integrase family
VY92_RS01175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VY92_RS01180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VY92_RS01185	COG0720	synthase
VY92_RS01190	COG0602	queuosine metabolic process
VY92_RS01220	COG1215	transferase activity, transferring glycosyl groups
VY92_RS01265	COG1793	dna ligase
VY92_RS01270	COG0363	glucosamine-6-phosphate deaminase activity
VY92_RS01275	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VY92_RS01280	COG0590	tRNA wobble adenosine to inosine editing
VY92_RS01295	COG0730	response to heat
VY92_RS01300	COG0494	nUDIX hydrolase
VY92_RS01310	COG3023	N-Acetylmuramoyl-L-alanine amidase
VY92_RS01315	COG4969	Belongs to the N-Me-Phe pilin family
VY92_RS01320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VY92_RS01325	COG0528	UMP kinase activity
VY92_RS01345	COG0575	Belongs to the CDS family
VY92_RS01350	COG0750	zinc metalloprotease
VY92_RS01360	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VY92_RS01365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VY92_RS01370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VY92_RS01385	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VY92_RS01395	COG1466	dna polymerase III delta subunit
VY92_RS01400	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VY92_RS01405	COG0495	leucyl-tRNA aminoacylation
VY92_RS01425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VY92_RS01430	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
VY92_RS01435	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VY92_RS01470	COG0328	RNA-DNA hybrid ribonuclease activity
VY92_RS01485	COG3716	PTS system mannose fructose sorbose family IID component
VY92_RS01490	COG3715	PTS system
VY92_RS01495	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VY92_RS01495	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY92_RS01500	COG1459	type II secretion system
VY92_RS01510	COG0237	dephospho-CoA kinase activity
VY92_RS01510	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VY92_RS01520	COG1115	amino acid carrier protein
VY92_RS01525	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VY92_RS01530	COG1917	Cupin 2, conserved barrel domain protein
VY92_RS01530	COG4977	sequence-specific DNA binding
VY92_RS01535	COG5413	integral membrane protein
VY92_RS01545	COG4178	(ABC) transporter
VY92_RS01555	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
VY92_RS01570	COG1454	alcohol dehydrogenase
VY92_RS01570	COG1012	belongs to the aldehyde dehydrogenase family
VY92_RS01575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VY92_RS01580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VY92_RS01590	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VY92_RS01595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VY92_RS01600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VY92_RS01605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VY92_RS01640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VY92_RS01650	COG2990	Protein conserved in bacteria
VY92_RS01655	COG0612	Peptidase, M16
VY92_RS01660	COG4771	TonB-dependent receptor
VY92_RS01670	COG0539	negative regulation of cytoplasmic translation
VY92_RS01675	COG0776	regulation of translation
VY92_RS01680	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VY92_RS01685	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VY92_RS01695	COG0023	Translation Initiation Factor
VY92_RS01715	COG0745	RESPONSE REGULATOR receiver
VY92_RS01720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VY92_RS01725	COG0151	Belongs to the GarS family
VY92_RS01740	COG2259	Doxx family
VY92_RS01745	COG5295	Hep Hag repeat protein
VY92_RS01760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VY92_RS01765	COG4172	Belongs to the ABC transporter superfamily
VY92_RS01770	COG4172	Belongs to the ABC transporter superfamily
VY92_RS01775	COG4171	peptide transport system, permease
VY92_RS01780	COG4168	peptide transport system, permease
VY92_RS01785	COG4166	transmembrane transport
VY92_RS01790	COG3106	COG3106 Predicted ATPase
VY92_RS01800	COG3283	Transcriptional regulator of aromatic amino acids metabolism
VY92_RS01815	COG0012	GTP binding
VY92_RS01825	COG2867	negative regulation of translational initiation
VY92_RS01835	COG2850	peptidyl-arginine hydroxylation
VY92_RS01850	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VY92_RS01855	COG0739	heme binding
VY92_RS01865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VY92_RS01870	COG0443	Heat shock 70 kDa protein
VY92_RS01875	COG0484	heat shock protein binding
VY92_RS01885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VY92_RS01890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VY92_RS01895	COG1643	Atp-dependent helicase
VY92_RS01905	COG0471	metal ion transport
VY92_RS01915	COG0583	DNA-binding transcription factor activity
VY92_RS01920	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
VY92_RS01925	COG1687	branched-chain amino acid
VY92_RS01945	COG2864	formate dehydrogenase
VY92_RS01950	COG0437	4 iron, 4 sulfur cluster binding
VY92_RS01975	COG0531	amino acid
VY92_RS01980	COG1982	Orn Lys Arg decarboxylase major
VY92_RS02055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VY92_RS02065	COG3021	interspecies interaction between organisms
VY92_RS02070	COG0251	oxidation-reduction process
VY92_RS02095	COG0270	DNA (cytosine-5-)-methyltransferase activity
VY92_RS02135	COG2974	May be involved in recombination
VY92_RS02210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VY92_RS02235	COG1484	DNA-dependent DNA replication
VY92_RS02425	COG3179	chitinase
VY92_RS02450	COG3646	Phage regulatory protein
VY92_RS02485	COG0582	viral genome integration into host DNA
VY92_RS02490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VY92_RS02490	COG0519	Catalyzes the synthesis of GMP from XMP
VY92_RS02505	COG0516	GMP reductase activity
VY92_RS02505	COG0517	IMP dehydrogenase activity
VY92_RS02510	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
VY92_RS02510	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
VY92_RS02520	COG3422	double-strand break repair
VY92_RS02535	COG0134	indole-3-glycerol-phosphate synthase activity
VY92_RS02535	COG0135	phosphoribosylanthranilate isomerase activity
VY92_RS02540	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VY92_RS02545	COG1942	4-Oxalocrotonate Tautomerase
VY92_RS02550	COG0512	Glutamine amidotransferase of anthranilate synthase
VY92_RS02555	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VY92_RS02565	COG2927	DNA polymerase III (CHI subunit)
VY92_RS02570	COG2153	protein acetylation
VY92_RS02580	COG4185	zeta toxin
VY92_RS02595	COG0525	valine-tRNA ligase activity
VY92_RS02600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VY92_RS02605	COG2249	NAD(P)H dehydrogenase (quinone) activity
VY92_RS02620	COG2814	Major facilitator Superfamily
VY92_RS02640	COG4221	oxidoreductase activity
VY92_RS02655	COG3094	Invasion gene expression up-regulator, SirB
VY92_RS02660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VY92_RS02670	COG0735	belongs to the Fur family
VY92_RS02675	COG0716	FMN binding
VY92_RS02685	COG0596	Alpha beta hydrolase
VY92_RS02690	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VY92_RS02695	COG0318	PFAM AMP-dependent synthetase and ligase
VY92_RS02700	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VY92_RS02700	COG3264	Mechanosensitive ion channel
VY92_RS02710	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
VY92_RS02715	COG0730	response to heat
VY92_RS02720	COG1560	Kdo2-lipid A biosynthetic process
VY92_RS02725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VY92_RS02730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VY92_RS02735	COG1966	Carbon starvation protein
VY92_RS02740	COG0673	inositol 2-dehydrogenase activity
VY92_RS02745	COG2186	Transcriptional regulator
VY92_RS02750	COG3842	ATPase activity
VY92_RS02760	COG1175	transmembrane transport
VY92_RS02770	COG0673	inositol 2-dehydrogenase activity
VY92_RS02780	COG0281	malic enzyme
VY92_RS02785	COG1733	regulation of RNA biosynthetic process
VY92_RS02795	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VY92_RS02800	COG1177	transmembrane transport
VY92_RS02805	COG1176	ABC-type spermidine putrescine transport system, permease component I
VY92_RS02810	COG3842	ATPase activity
VY92_RS02820	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VY92_RS02825	COG4143	(ABC) transporter
VY92_RS02830	COG1178	ABC-type Fe3 transport system permease component
VY92_RS02835	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VY92_RS02845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VY92_RS02850	COG0730	response to heat
VY92_RS02865	COG0786	glutamate:sodium symporter activity
VY92_RS02870	COG2005	Transcriptional regulator
VY92_RS02875	COG0725	ABC transporter, periplasmic molybdate-binding protein
VY92_RS02880	COG4149	molybdate abc transporter
VY92_RS02885	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VY92_RS02895	COG3102	Protein conserved in bacteria
VY92_RS02900	COG0305	Participates in initiation and elongation during chromosome replication
VY92_RS02920	COG2932	Transcriptional regulator
VY92_RS02955	COG3077	Addiction module antitoxin, RelB DinJ family
VY92_RS02960	COG3041	Addiction module toxin RelE StbE family
VY92_RS02970	COG0494	nUDIX hydrolase
VY92_RS02995	COG1929	Belongs to the glycerate kinase type-1 family
VY92_RS03000	COG2610	gluconate transmembrane transporter activity
VY92_RS03005	COG3835	regulator
VY92_RS03010	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VY92_RS03015	COG1448	Aminotransferase
VY92_RS03020	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VY92_RS03025	COG0288	reversible hydration of carbon dioxide
VY92_RS03030	COG0306	phosphate transporter
VY92_RS03035	COG1392	Phosphate transport regulator
VY92_RS03040	COG3025	triphosphatase activity
VY92_RS03045	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VY92_RS03050	COG3266	domain, Protein
VY92_RS03050	COG3468	outer membrane autotransporter barrel domain protein
VY92_RS03060	COG0352	thiamine-phosphate diphosphorylase activity
VY92_RS03065	COG0351	phosphomethylpyrimidine kinase
VY92_RS03075	COG0658	competence protein
VY92_RS03075	COG2333	competence protein COMEC
VY92_RS03080	COG1132	(ABC) transporter
VY92_RS03085	COG1663	tetraacyldisaccharide 4'-kinase activity
VY92_RS03090	COG2835	tetraacyldisaccharide 4'-kinase activity
VY92_RS03095	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VY92_RS03100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VY92_RS03105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VY92_RS03110	COG1116	anion transmembrane transporter activity
VY92_RS03115	COG0322	excinuclease ABC activity
VY92_RS03120	COG0586	Pfam SNARE associated Golgi protein
VY92_RS03125	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VY92_RS03130	COG0673	inositol 2-dehydrogenase activity
VY92_RS03140	COG0307	riboflavin synthase, alpha
VY92_RS03170	COG0671	phosphoesterase, PA-phosphatase related
VY92_RS03175	COG1940	carbohydrate kinase activity
VY92_RS03190	COG1115	amino acid carrier protein
VY92_RS03195	COG0515	serine threonine protein kinase
VY92_RS03210	COG0195	Participates in both transcription termination and antitermination
VY92_RS03215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VY92_RS03225	COG1566	PFAM secretion protein HlyD family protein
VY92_RS03245	COG2350	Protein conserved in bacteria
VY92_RS03250	COG1607	acyl-coa hydrolase
VY92_RS03265	COG3047	cAMP biosynthetic process
VY92_RS03280	COG0247	lactate metabolic process
VY92_RS03280	COG0277	FAD linked oxidase domain protein
VY92_RS03290	COG1704	LemA family
VY92_RS03335	COG4991	sh3 domain protein
VY92_RS03340	COG0617	tRNA 3'-terminal CCA addition
VY92_RS03345	COG3955	Domain of unknown function (DUF1919)
VY92_RS03350	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VY92_RS03355	COG1984	allophanate hydrolase subunit 2
VY92_RS03360	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VY92_RS03365	COG1914	H( )-stimulated, divalent metal cation uptake system
VY92_RS03380	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VY92_RS03390	COG0708	Exodeoxyribonuclease III
VY92_RS03405	COG0616	signal peptide processing
VY92_RS03410	COG1840	ABC-type Fe3 transport system, periplasmic component
VY92_RS03415	COG1408	metallophosphoesterase
VY92_RS03420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VY92_RS03425	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VY92_RS03430	COG2863	cytochrome
VY92_RS03440	COG1199	ATP-dependent helicase activity
VY92_RS03445	COG1214	PFAM Peptidase M22, glycoprotease
VY92_RS03450	COG0318	PFAM AMP-dependent synthetase and ligase
VY92_RS03455	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VY92_RS03470	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VY92_RS03475	COG4988	ABC transporter
VY92_RS03480	COG0492	ferredoxin-NADP+ reductase activity
VY92_RS03485	COG3118	belongs to the thioredoxin family
VY92_RS03490	COG2610	gluconate transmembrane transporter activity
VY92_RS03495	COG3265	gluconokinase activity
VY92_RS03505	COG0733	neurotransmitter:sodium symporter activity
VY92_RS03510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VY92_RS03525	COG4658	electron transport chain
VY92_RS03530	COG4656	Part of a membrane complex involved in electron transport
VY92_RS03540	COG4657	Part of a membrane complex involved in electron transport
VY92_RS03545	COG1090	epimerase
VY92_RS03550	COG1438	arginine binding
VY92_RS03555	COG0039	L-malate dehydrogenase activity
VY92_RS03565	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VY92_RS03570	COG0517	IMP dehydrogenase activity
VY92_RS03570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VY92_RS03600	COG0285	dihydrofolate synthase activity
VY92_RS03605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VY92_RS03610	COG3140	Belongs to the UPF0181 family
VY92_RS03615	COG1278	Cold shock
VY92_RS03630	COG1609	Transcriptional regulator
VY92_RS03645	COG1067	ATP-dependent peptidase activity
VY92_RS03655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VY92_RS03660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VY92_RS03665	COG2252	PERMEase
VY92_RS03670	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VY92_RS03675	COG1074	ATP-dependent DNA helicase activity
VY92_RS03680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VY92_RS03695	COG1846	Transcriptional regulator
VY92_RS03695	COG1940	carbohydrate kinase activity
VY92_RS03705	COG0788	formyltetrahydrofolate deformylase activity
VY92_RS03710	COG0406	alpha-ribazole phosphatase activity
VY92_RS03720	COG0564	pseudouridine synthase activity
VY92_RS03735	COG0776	regulation of translation
VY92_RS03740	COG0791	NLP P60 protein
VY92_RS03775	COG0697	spore germination
VY92_RS03780	COG2925	Exonuclease
VY92_RS03795	COG3676	manually curated
VY92_RS03800	COG2969	positive regulation of protein catabolic process
VY92_RS03825	COG3098	single-species biofilm formation
VY92_RS03830	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VY92_RS03845	COG1611	Belongs to the LOG family
VY92_RS03850	COG4453	Protein conserved in bacteria
VY92_RS03860	COG1215	transferase activity, transferring glycosyl groups
VY92_RS03865	COG0842	Transport permease protein
VY92_RS03870	COG1131	(ABC) transporter
VY92_RS03875	COG3101	peptidyl-lysine hydroxylation
VY92_RS03885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VY92_RS03905	COG1523	belongs to the glycosyl hydrolase 13 family
VY92_RS03910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VY92_RS03915	COG1640	4-alpha-glucanotransferase
VY92_RS03920	COG3152	Membrane
VY92_RS03940	COG0577	efflux transmembrane transporter activity
VY92_RS03940	COG1136	(ABC) transporter
VY92_RS03945	COG1538	Outer membrane efflux protein
VY92_RS03955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VY92_RS03960	COG0508	dehydrogenase complex catalyzes the overall conversion of
VY92_RS03965	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VY92_RS03970	COG2190	(PTS) system
VY92_RS03975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VY92_RS03980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY92_RS03985	COG1162	GTPase activity
VY92_RS03990	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VY92_RS04010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VY92_RS04015	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VY92_RS04040	COG1522	sequence-specific DNA binding
VY92_RS04050	COG1346	cytolysis
VY92_RS04055	COG1380	Effector of murein hydrolase LrgA
VY92_RS04060	COG1525	nuclease
VY92_RS04070	COG2166	iron-sulfur cluster assembly
VY92_RS04075	COG2268	Band 7 protein
VY92_RS04090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VY92_RS04095	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VY92_RS04095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VY92_RS04105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VY92_RS04110	COG0617	tRNA 3'-terminal CCA addition
VY92_RS04115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VY92_RS04120	COG0301	tRNA thio-modification
VY92_RS04120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VY92_RS04130	COG0142	geranyltranstransferase activity
VY92_RS04140	COG1534	Rna-binding protein
VY92_RS04150	COG3217	Mosc domain protein beta barrel domain protein
VY92_RS04150	COG0633	Ferredoxin
VY92_RS04160	COG0287	Prephenate dehydrogenase
VY92_RS04160	COG1605	Chorismate mutase
VY92_RS04165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VY92_RS04170	COG0613	PHP domain protein
VY92_RS04175	COG0167	dihydroorotate dehydrogenase activity
VY92_RS04180	COG0308	aminopeptidase N
VY92_RS04185	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VY92_RS04230	COG0163	prenyltransferase activity
VY92_RS04240	COG1286	toxin biosynthetic process
VY92_RS04245	COG3092	negative regulation of chromosome organization
VY92_RS04255	COG0280	phosphate acetyltransferase
VY92_RS04255	COG0857	belongs to the CobB CobQ family
VY92_RS04280	COG0668	transmembrane transport
VY92_RS04285	COG0795	lipopolysaccharide-transporting ATPase activity
VY92_RS04290	COG0795	lipopolysaccharide-transporting ATPase activity
VY92_RS04315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VY92_RS04320	COG2226	methyltransferase
VY92_RS04325	COG1944	ATP diphosphatase activity
VY92_RS04330	COG3105	Protein conserved in bacteria
VY92_RS04335	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VY92_RS04350	COG0633	Ferredoxin
VY92_RS04360	COG1280	lysine exporter protein (LysE YggA)
VY92_RS04365	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VY92_RS04370	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VY92_RS04375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VY92_RS04385	COG0814	amino acid
VY92_RS04395	COG2062	phosphohistidine phosphatase, SixA
VY92_RS04405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VY92_RS04415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VY92_RS04420	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VY92_RS04420	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VY92_RS04425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VY92_RS04465	COG2999	glutathione oxidoreductase activity
VY92_RS04500	COG1476	TRANSCRIPTIONal
VY92_RS04505	COG0582	viral genome integration into host DNA
VY92_RS04525	COG3306	glycosyltransferase involved in LPS biosynthesis
VY92_RS04530	COG3306	glycosyltransferase involved in LPS biosynthesis
VY92_RS04550	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
VY92_RS04555	COG3683	transport system, periplasmic component
VY92_RS04560	COG0488	(ABC) transporter
VY92_RS04565	COG2195	Cleaves the N-terminal amino acid of tripeptides
VY92_RS04580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VY92_RS04585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VY92_RS04590	COG1957	nucleoside hydrolase
VY92_RS04595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VY92_RS04600	COG0670	Belongs to the BI1 family
VY92_RS04605	COG2920	part of a sulfur-relay system
VY92_RS04615	COG1121	(ABC) transporter
VY92_RS04620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VY92_RS04625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VY92_RS04630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VY92_RS04635	COG2949	membrane
VY92_RS04645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VY92_RS04650	COG4591	ABC-type transport system involved in lipoprotein release permease component
VY92_RS04655	COG1136	(ABC) transporter
VY92_RS04660	COG4591	ABC-type transport system involved in lipoprotein release permease component
VY92_RS04665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VY92_RS04685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VY92_RS04695	COG1289	transmembrane transporter activity
VY92_RS04710	COG0314	molybdopterin synthase activity
VY92_RS04715	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VY92_RS04720	COG0315	cyclic pyranopterin monophosphate synthase activity
VY92_RS04765	COG1696	Membrane protein involved in D-alanine export
VY92_RS04775	COG0303	'Molybdopterin
VY92_RS04780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VY92_RS04785	COG2431	L-lysine efflux transmembrane transporter activity
VY92_RS04790	COG1528	Iron-storage protein
VY92_RS04795	COG1528	Iron-storage protein
VY92_RS04805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VY92_RS04810	COG0589	response to stress
VY92_RS04820	COG2171	N-acyltransferase activity
VY92_RS04825	COG0583	DNA-binding transcription factor activity
VY92_RS04835	COG0009	L-threonylcarbamoyladenylate synthase
VY92_RS04850	COG0792	nuclease activity
VY92_RS04855	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VY92_RS04860	COG2823	Periplasmic or secreted lipoprotein
VY92_RS04865	COG0210	DNA helicase
VY92_RS04885	COG0583	DNA-binding transcription factor activity
VY92_RS04890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VY92_RS04905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VY92_RS04910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VY92_RS04925	COG0626	cystathionine gamma-synthase activity
VY92_RS04930	COG0450	alkyl hydroperoxide reductase
VY92_RS04935	COG3100	YcgL domain-containing protein
VY92_RS04940	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VY92_RS04940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VY92_RS04945	COG1560	Kdo2-lipid A biosynthetic process
VY92_RS04950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VY92_RS04955	COG3108	Peptidase M15
VY92_RS04960	COG2989	Protein conserved in bacteria
VY92_RS04965	COG0793	Belongs to the peptidase S41A family
VY92_RS04970	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VY92_RS04975	COG2995	paraquat-inducible protein a
VY92_RS04985	COG0187	DNA topoisomerase II activity
VY92_RS05000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VY92_RS05005	COG1328	CTP reductase activity
VY92_RS05010	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VY92_RS05035	COG0583	DNA-binding transcription factor activity
VY92_RS05040	COG0616	signal peptide processing
VY92_RS05045	COG0778	Nitroreductase
VY92_RS05065	COG0039	L-malate dehydrogenase activity
VY92_RS05070	COG0440	acetolactate synthase activity
VY92_RS05075	COG0028	Belongs to the TPP enzyme family
VY92_RS05080	COG1757	Na H antiporter
VY92_RS05095	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VY92_RS05120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VY92_RS05145	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VY92_RS05150	COG0494	nUDIX hydrolase
VY92_RS05160	COG1876	peptidase activity
VY92_RS05165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VY92_RS05170	COG1393	Belongs to the ArsC family
VY92_RS05190	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VY92_RS05195	COG0083	homoserine kinase activity
VY92_RS05200	COG0527	aspartate kinase activity
VY92_RS05200	COG0460	homoserine dehydrogenase
VY92_RS05210	COG0346	lactoylglutathione lyase activity
VY92_RS05215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VY92_RS05220	COG2056	Na+-H+ antiporter family
VY92_RS05225	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
VY92_RS05225	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
VY92_RS05225	COG0506	proline dehydrogenase activity
VY92_RS05230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VY92_RS05245	COG3945	hemerythrin HHE cation binding domain
VY92_RS05250	COG1862	Preprotein translocase
VY92_RS05255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VY92_RS05260	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VY92_RS05265	COG0741	lytic transglycosylase activity
VY92_RS05280	COG4221	oxidoreductase activity
VY92_RS05285	COG2814	Major facilitator Superfamily
VY92_RS05310	COG3210	domain, Protein
VY92_RS05335	COG2189	Belongs to the N(4) N(6)-methyltransferase family
VY92_RS05345	COG0583	DNA-binding transcription factor activity
VY92_RS05350	COG0642	Histidine kinase
VY92_RS05355	COG0745	RESPONSE REGULATOR receiver
VY92_RS05360	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VY92_RS05370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VY92_RS05375	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VY92_RS05385	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VY92_RS05390	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VY92_RS05405	COG3119	arylsulfatase activity
VY92_RS05415	COG2089	acid synthase
VY92_RS05430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VY92_RS05440	COG1621	beta-fructofuranosidase activity
VY92_RS05455	COG0802	atpase or kinase
VY92_RS05460	COG0860	N-Acetylmuramoyl-L-alanine amidase
VY92_RS05460	COG1388	LysM domain
VY92_RS05465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VY92_RS05475	COG1923	regulation of RNA biosynthetic process
VY92_RS05480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VY92_RS05490	COG3099	Belongs to the UPF0263 family
VY92_RS05515	COG4735	regulation of single-species biofilm formation
VY92_RS05555	COG2378	regulation of single-species biofilm formation
VY92_RS05570	COG1741	Belongs to the pirin family
VY92_RS05575	COG2951	lytic endotransglycosylase activity
VY92_RS05580	COG1216	Glycosyl transferase, family 2
VY92_RS05585	COG1216	Glycosyl transferase, family 2
VY92_RS05595	COG3306	glycosyltransferase involved in LPS biosynthesis
VY92_RS05605	COG5039	Polysaccharide pyruvyl transferase
VY92_RS05610	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VY92_RS05615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VY92_RS05620	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VY92_RS05620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VY92_RS05625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VY92_RS05625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VY92_RS05630	COG0489	protein tyrosine kinase activity
VY92_RS05635	COG0672	)-iron permease
VY92_RS05650	COG1136	(ABC) transporter
VY92_RS05650	COG0577	efflux transmembrane transporter activity
VY92_RS05660	COG1136	(ABC) transporter
VY92_RS05665	COG0676	glucose-6-phosphate 1-epimerase activity
VY92_RS05680	COG3177	Filamentation induced by cAMP protein fic
VY92_RS05690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VY92_RS05695	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VY92_RS05700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VY92_RS05705	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
VY92_RS05705	COG2885	chlorophyll binding
VY92_RS05710	COG2824	Alkylphosphonate utilization operon protein PhnA
VY92_RS05715	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VY92_RS05720	COG1120	ATPase activity
VY92_RS05740	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
VY92_RS05745	COG4774	siderophore transport
VY92_RS05750	COG4774	siderophore transport
VY92_RS05760	COG0814	amino acid
VY92_RS05765	COG2964	Protein conserved in bacteria
VY92_RS05775	COG0469	pyruvate kinase activity
VY92_RS05780	COG0778	Nitroreductase
VY92_RS05790	COG0037	tRNA processing
VY92_RS05795	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VY92_RS05805	COG0508	dehydrogenase complex catalyzes the overall conversion of
VY92_RS05810	COG0567	Dehydrogenase, E1 component
VY92_RS05815	COG0372	Belongs to the citrate synthase family
VY92_RS05820	COG3381	protein complex oligomerization
VY92_RS05825	COG2249	NAD(P)H dehydrogenase (quinone) activity
VY92_RS05835	COG0330	HflC and HflK could
VY92_RS05865	COG1846	Transcriptional regulator
VY92_RS05865	COG1940	carbohydrate kinase activity
VY92_RS05880	COG0497	DNA recombination
VY92_RS05885	COG0360	Binds together with S18 to 16S ribosomal RNA
VY92_RS05890	COG2965	DNA replication, synthesis of RNA primer
VY92_RS05915	COG1530	ribonuclease E activity
VY92_RS05970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VY92_RS05980	COG0024	Methionine aminopeptidase
VY92_RS05985	COG0316	Belongs to the HesB IscA family
VY92_RS05995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VY92_RS06005	COG4166	transmembrane transport
VY92_RS06010	COG2832	Protein of unknown function (DUF454)
VY92_RS06015	COG0339	signal peptide processing
VY92_RS06020	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VY92_RS06025	COG1053	succinate dehydrogenase
VY92_RS06030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VY92_RS06040	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VY92_RS06050	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VY92_RS06055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VY92_RS06060	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VY92_RS06075	COG1278	Cold shock
VY92_RS06080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VY92_RS06090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VY92_RS06095	COG5007	Belongs to the BolA IbaG family
VY92_RS06100	COG3113	response to antibiotic
VY92_RS06105	COG2854	intermembrane phospholipid transfer
VY92_RS06110	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VY92_RS06115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VY92_RS06120	COG1127	ABC transporter
VY92_RS06130	COG3117	lipopolysaccharide transmembrane transporter activity
VY92_RS06135	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VY92_RS06140	COG1137	ATPase activity
VY92_RS06145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY92_RS06160	COG2186	Transcriptional regulator
VY92_RS06175	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VY92_RS06190	COG1028	Short-chain dehydrogenase reductase Sdr
VY92_RS06240	COG2267	carboxylic ester hydrolase activity
VY92_RS06255	COG0436	Aminotransferase
VY92_RS06275	COG0861	Integral membrane protein TerC family
VY92_RS06285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VY92_RS06290	COG2067	long-chain fatty acid transport protein
VY92_RS06300	COG2860	membrane
VY92_RS06310	COG0527	aspartate kinase activity
VY92_RS06315	COG2897	thiosulfate sulfurtransferase activity
VY92_RS06320	COG2391	methyltransferase activity
VY92_RS06325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VY92_RS06340	COG3684	Belongs to the aldolase LacD family
VY92_RS06345	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VY92_RS06350	COG1349	DNA-binding transcription factor activity
VY92_RS06360	COG3119	arylsulfatase activity
VY92_RS06365	COG0641	radical SAM
VY92_RS06375	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
VY92_RS06380	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY92_RS06380	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VY92_RS06385	COG3716	PTS system mannose fructose sorbose family IID component
VY92_RS06390	COG3715	PTS system
VY92_RS06395	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VY92_RS06400	COG2222	sugar isomerase
VY92_RS06410	COG3119	arylsulfatase activity
VY92_RS06420	COG1028	Short-chain dehydrogenase reductase Sdr
VY92_RS06430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VY92_RS06435	COG0800	Aldolase
VY92_RS06440	COG0584	glycerophosphoryl diester phosphodiesterase
VY92_RS06445	COG3842	ATPase activity
VY92_RS06455	COG1177	transmembrane transport
VY92_RS06480	COG1509	lysine 2,3-aminomutase activity
VY92_RS06485	COG3266	domain, Protein
VY92_RS06485	COG3061	Opacity-associated protein A
VY92_RS06495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VY92_RS06500	COG2814	Major facilitator Superfamily
VY92_RS06505	COG4974	Belongs to the 'phage' integrase family
VY92_RS06510	COG1605	Chorismate mutase
VY92_RS06510	COG0077	Prephenate dehydratase
VY92_RS06515	COG3321	synthase
VY92_RS06515	COG0604	alcohol dehydrogenase
VY92_RS06515	COG1028	Short-chain dehydrogenase reductase Sdr
VY92_RS06530	COG4221	oxidoreductase activity
VY92_RS06545	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VY92_RS06550	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VY92_RS06555	COG0849	cell division
VY92_RS06560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VY92_RS06585	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VY92_RS06595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VY92_RS06605	COG0768	penicillin binding
VY92_RS06610	COG3116	cell division
VY92_RS06630	COG1444	tRNA N-acetyltransferase activity
VY92_RS06640	COG1702	phosphate starvation-inducible protein PhoH
VY92_RS06650	COG0204	Acyl-transferase
VY92_RS06660	COG0121	glutamine amidotransferase
VY92_RS06665	COG0814	amino acid
VY92_RS06670	COG1760	l-serine dehydratase
VY92_RS06675	COG1138	Cytochrome C-type biogenesis protein
VY92_RS06685	COG3088	subunit of a heme lyase
VY92_RS06685	COG4235	cytochrome complex assembly
VY92_RS06690	COG4235	cytochrome complex assembly
VY92_RS06690	COG3088	subunit of a heme lyase
VY92_RS06695	COG2081	HI0933 family
VY92_RS06705	COG3301	Polysulphide reductase, NrfD
VY92_RS06710	COG0437	4 iron, 4 sulfur cluster binding
VY92_RS06715	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VY92_RS06720	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VY92_RS06740	COG1686	Belongs to the peptidase S11 family
VY92_RS06750	COG0772	Belongs to the SEDS family
VY92_RS06755	COG0768	penicillin binding
VY92_RS06765	COG0799	negative regulation of ribosome biogenesis
VY92_RS06770	COG0513	Belongs to the DEAD box helicase family
VY92_RS06775	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VY92_RS06805	COG3842	ATPase activity
VY92_RS06835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VY92_RS06840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VY92_RS06850	COG0194	GDP metabolic process
VY92_RS06855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VY92_RS06860	COG3676	manually curated
VY92_RS06865	COG0545	Peptidyl-prolyl cis-trans isomerase
VY92_RS06885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VY92_RS06895	COG2830	Protein of unknown function (DUF452)
VY92_RS06900	COG0500	methyltransferase
VY92_RS06905	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VY92_RS06910	COG1399	metal-binding, possibly nucleic acid-binding protein
VY92_RS06920	COG0416	fatty acid biosynthetic process
VY92_RS06925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VY92_RS06930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VY92_RS06935	COG1028	Short-chain dehydrogenase reductase Sdr
VY92_RS06950	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VY92_RS06960	COG0656	L-ascorbic acid biosynthetic process
VY92_RS07035	COG1077	Cell shape determining protein MreB Mrl
VY92_RS07040	COG1792	Involved in formation and maintenance of cell shape
VY92_RS07045	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VY92_RS07050	COG0748	coenzyme F420 binding
VY92_RS07055	COG3721	Heme iron utilization protein
VY92_RS07060	COG4771	TonB-dependent receptor
VY92_RS07080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VY92_RS07090	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
VY92_RS07100	COG2731	YhcH YjgK YiaL family protein
VY92_RS07105	COG1737	Transcriptional regulator
VY92_RS07115	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VY92_RS07135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VY92_RS07160	COG1172	Belongs to the binding-protein-dependent transport system permease family
VY92_RS07165	COG1129	ABC transporter
VY92_RS07175	COG1879	ABC-type sugar transport system periplasmic component
VY92_RS07180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VY92_RS07185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VY92_RS07190	COG0006	proline dipeptidase activity
VY92_RS07210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VY92_RS07215	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VY92_RS07220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VY92_RS07225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VY92_RS07230	COG1720	tRNA m6t6A37 methyltransferase activity
VY92_RS07240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VY92_RS07245	COG0471	metal ion transport
VY92_RS07250	COG2226	methyltransferase
VY92_RS07260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VY92_RS07270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VY92_RS07275	COG0805	protein transport
VY92_RS07285	COG0084	hydrolase, TatD family'
VY92_RS07290	COG0602	queuosine metabolic process
VY92_RS07300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VY92_RS07315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VY92_RS07375	COG2026	Addiction module toxin, RelE StbE family
VY92_RS07405	COG0582	viral genome integration into host DNA
VY92_RS07430	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VY92_RS07435	COG0494	nUDIX hydrolase
VY92_RS07450	COG4701	Protein of unknown function (DUF721)
VY92_RS07455	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VY92_RS07460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VY92_RS07470	COG4796	Type ii and iii secretion system protein
VY92_RS07490	COG4972	Pilus assembly protein
VY92_RS07495	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VY92_RS07500	COG3676	manually curated
VY92_RS07525	COG2852	Protein conserved in bacteria
VY92_RS07530	COG4804	nuclease activity
VY92_RS07540	COG4545	Glutaredoxin-related protein
VY92_RS07545	COG0752	glycyl-tRNA synthetase alpha subunit
VY92_RS07575	COG0582	viral genome integration into host DNA
VY92_RS07585	COG3617	BRO family, N-terminal domain
VY92_RS07610	COG0629	single-stranded DNA binding
VY92_RS07755	COG1846	Transcriptional regulator
VY92_RS07780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VY92_RS07855	COG2974	May be involved in recombination
VY92_RS07905	COG0582	viral genome integration into host DNA
VY92_RS07925	COG0626	cystathionine gamma-synthase activity
VY92_RS07930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VY92_RS07940	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VY92_RS07945	COG0142	geranyltranstransferase activity
VY92_RS07960	COG0697	spore germination
VY92_RS08065	COG3210	domain, Protein
VY92_RS08065	COG3210	domain, Protein
VY92_RS08070	COG2831	hemolysin activation secretion protein
VY92_RS08080	COG1846	Transcriptional regulator
VY92_RS08095	COG1846	Transcriptional regulator
VY92_RS08100	COG1566	PFAM secretion protein HlyD family protein
VY92_RS08105	COG2814	Major facilitator Superfamily
VY92_RS08115	COG0557	exoribonuclease II activity
VY92_RS08135	COG0681	Belongs to the peptidase S26 family
VY92_RS08175	COG0105	UTP biosynthetic process
VY92_RS08195	COG2198	Histidine kinase
VY92_RS08195	COG0784	Response regulator, receiver
VY92_RS08195	COG5002	protein histidine kinase activity
VY92_RS08200	COG0385	Bile acid
VY92_RS08205	COG2814	Major facilitator Superfamily
VY92_RS08210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VY92_RS08220	COG2252	PERMEase
VY92_RS08225	COG1555	photosystem II stabilization
VY92_RS08230	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VY92_RS08235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VY92_RS08245	COG1238	metal cluster binding
VY92_RS08250	COG0110	maltose O-acetyltransferase activity
VY92_RS08255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VY92_RS08280	COG1238	metal cluster binding
VY92_RS08300	COG4783	chaperone-mediated protein folding
VY92_RS08310	COG0814	amino acid
VY92_RS08315	COG2226	methyltransferase
VY92_RS08320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VY92_RS08325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VY92_RS08340	COG0131	Imidazoleglycerol-phosphate dehydratase
VY92_RS08340	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VY92_RS08345	COG4804	nuclease activity
VY92_RS08355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VY92_RS08365	COG0107	imidazoleglycerol-phosphate synthase activity
VY92_RS08380	COG3161	chorismate lyase activity
VY92_RS08385	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VY92_RS08390	COG2233	PERMEase
VY92_RS08395	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VY92_RS08400	COG0066	3-isopropylmalate dehydratase activity
VY92_RS08405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VY92_RS08420	COG4133	protoheme IX ABC transporter activity
VY92_RS08425	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VY92_RS08430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VY92_RS08435	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VY92_RS08445	COG1138	Cytochrome C-type biogenesis protein
VY92_RS08450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VY92_RS08465	COG4211	Belongs to the binding-protein-dependent transport system permease family
VY92_RS08470	COG1129	ABC transporter
VY92_RS08475	COG1879	ABC-type sugar transport system periplasmic component
VY92_RS08480	COG1085	galactose-1-phosphate uridylyltransferase
VY92_RS08490	COG2017	converts alpha-aldose to the beta-anomer
VY92_RS08500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VY92_RS08505	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
VY92_RS08510	COG1882	Formate acetyltransferase
VY92_RS08515	COG2116	formate transmembrane transporter activity
VY92_RS08520	COG0537	adenosine 5'-monophosphoramidase activity
VY92_RS08535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VY92_RS08550	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VY92_RS08555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VY92_RS08560	COG0254	rRNA binding
VY92_RS08565	COG1253	flavin adenine dinucleotide binding
VY92_RS08575	COG0084	hydrolase, TatD family'
VY92_RS08580	COG0470	DNA polymerase III
VY92_RS08585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VY92_RS08590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VY92_RS08600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VY92_RS08605	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VY92_RS08615	COG0330	HflC and HflK could
VY92_RS08620	COG0330	HflC and HflK could
VY92_RS08635	COG0326	Molecular chaperone. Has ATPase activity
VY92_RS08640	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
VY92_RS08645	COG3091	SprT-like family
VY92_RS08650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VY92_RS08655	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VY92_RS08695	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VY92_RS08715	COG0210	DNA helicase
VY92_RS08720	COG5645	(Lipo)protein
VY92_RS08735	COG1447	Phosphotransferase system cellobiose-specific component IIA
VY92_RS08740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VY92_RS08745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VY92_RS08750	COG1446	asparaginase
VY92_RS08755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VY92_RS08765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VY92_RS08770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VY92_RS08795	COG2183	response to ionizing radiation
VY92_RS08800	COG1114	Component of the transport system for branched-chain amino acids
VY92_RS08805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VY92_RS08825	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
VY92_RS08830	COG0456	acetyltransferase
VY92_RS08835	COG1022	Amp-dependent synthetase and ligase
VY92_RS08840	COG1027	Aspartate ammonia-lyase
VY92_RS08850	COG0740	serine-type endopeptidase activity
VY92_RS08875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VY92_RS08880	COG3263	regulation of cellular component size
VY92_RS08885	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VY92_RS08885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VY92_RS08895	COG3722	fumarate hydratase activity
VY92_RS08900	COG0246	Mannitol dehydrogenase
VY92_RS08915	COG0848	biopolymer transport protein
VY92_RS08920	COG0811	peptide transport
VY92_RS08925	COG4536	flavin adenine dinucleotide binding
VY92_RS08930	COG4137	Cytochrome C assembly protein
VY92_RS08935	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VY92_RS08945	COG3036	rescue of stalled ribosome
VY92_RS08950	COG1393	Belongs to the ArsC family
VY92_RS08960	COG1126	abc transporter atp-binding protein
VY92_RS08965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VY92_RS08970	COG4215	(ABC) transporter
VY92_RS08975	COG4160	amino acid transport
VY92_RS09000	COG0174	glutamine synthetase
VY92_RS09020	COG3306	glycosyltransferase involved in LPS biosynthesis
VY92_RS09035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VY92_RS09055	COG0312	modulator of DNA gyrase
VY92_RS09060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
VY92_RS09070	COG1271	oxidase subunit
VY92_RS09075	COG1294	oxidase, subunit
VY92_RS09085	COG3790	cyd operon protein YbgE
VY92_RS09095	COG0824	Thioesterase
VY92_RS09100	COG0811	peptide transport
VY92_RS09105	COG0848	biopolymer transport protein
VY92_RS09110	COG3064	Membrane
VY92_RS09135	COG2165	general secretion pathway protein
VY92_RS09140	COG4795	General secretion pathway protein
VY92_RS09155	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VY92_RS09160	COG0561	phosphatase activity
VY92_RS09165	COG0235	Class ii aldolase
VY92_RS09170	COG3623	hexulose-6-phosphate isomerase
VY92_RS09195	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VY92_RS09265	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
VY92_RS09270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VY92_RS09280	COG0425	Belongs to the sulfur carrier protein TusA family
VY92_RS09290	COG4942	peptidase
VY92_RS09295	COG2861	carbohydrate metabolic process
VY92_RS09300	COG1040	competence protein
VY92_RS09310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VY92_RS09325	COG3850	Histidine kinase
VY92_RS09330	COG3062	negative regulation of establishment of protein localization
VY92_RS09335	COG0243	molybdopterin cofactor binding
VY92_RS09340	COG0437	4 iron, 4 sulfur cluster binding
VY92_RS09345	COG0348	domain, Protein
VY92_RS09350	COG3043	anaerobic respiration
VY92_RS09355	COG3005	denitrification pathway
VY92_RS09365	COG4785	May be involved in cell division
VY92_RS09385	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
VY92_RS09390	COG0569	domain protein
VY92_RS09410	COG1252	NADH dehydrogenase
VY92_RS09415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VY92_RS09425	COG0191	fructose-bisphosphate aldolase activity
VY92_RS09430	COG0126	phosphoglycerate kinase activity
VY92_RS09435	COG3719	Belongs to the RNase T2 family
VY92_RS09440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VY92_RS09445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VY92_RS09450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VY92_RS09460	COG0778	Nitroreductase
VY92_RS09465	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VY92_RS09470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VY92_RS09485	COG1045	serine acetyltransferase
VY92_RS09490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VY92_RS09495	COG2194	sulfuric ester hydrolase activity
VY92_RS09500	COG0789	Transcriptional regulator
VY92_RS09515	COG0280	phosphate acetyltransferase
VY92_RS09515	COG0281	malic enzyme
VY92_RS09525	COG1368	sulfuric ester hydrolase activity
VY92_RS09530	COG0335	large ribosomal subunit rRNA binding
VY92_RS09540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VY92_RS09545	COG0228	four-way junction DNA binding
VY92_RS09550	COG0859	PFAM glycosyl transferase family 9
VY92_RS09555	COG0463	Glycosyl transferase, family 2
VY92_RS09560	COG0561	phosphatase activity
VY92_RS09565	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VY92_RS09565	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY92_RS09570	COG3715	PTS system
VY92_RS09575	COG3716	PTS system mannose fructose sorbose family IID component
VY92_RS09590	COG0633	Ferredoxin
VY92_RS09595	COG0443	Heat shock 70 kDa protein
VY92_RS09605	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VY92_RS09615	COG0822	iron-sulfur transferase activity
VY92_RS09625	COG1959	2 iron, 2 sulfur cluster binding
VY92_RS09630	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VY92_RS09645	COG2837	iron assimilation
VY92_RS09655	COG0513	Belongs to the DEAD box helicase family
VY92_RS09660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VY92_RS09670	COG2853	Lipoprotein
VY92_RS09695	COG0004	ammonium transporteR
VY92_RS09695	COG0004	ammonium transporteR
VY92_RS09700	COG3676	manually curated
VY92_RS09705	COG2990	Protein conserved in bacteria
VY92_RS09710	COG0433	COG0433 Predicted ATPase
VY92_RS09745	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VY92_RS09750	COG0668	transmembrane transport
VY92_RS09755	COG0248	Ppx GppA phosphatase
VY92_RS09760	COG2911	Protein conserved in bacteria
VY92_RS09770	COG0728	peptidoglycan biosynthetic process
VY92_RS09775	COG0268	Binds directly to 16S ribosomal RNA
VY92_RS09785	COG0560	Phosphoserine phosphatase
VY92_RS09800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VY92_RS09805	COG3085	chromosome segregation
VY92_RS09810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VY92_RS09815	COG3084	Protein conserved in bacteria
VY92_RS09825	COG0354	folic acid binding
VY92_RS09830	COG1561	YicC-like family, N-terminal region
VY92_RS09835	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VY92_RS09840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VY92_RS09845	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VY92_RS09855	COG0402	S-adenosylhomocysteine deaminase activity
VY92_RS09860	COG3083	sulfuric ester hydrolase activity
VY92_RS09875	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VY92_RS09880	COG0745	RESPONSE REGULATOR receiver
VY92_RS09885	COG1584	GPR1 FUN34 yaaH family protein
VY92_RS09890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VY92_RS09895	COG0085	RNA polymerase activity
VY92_RS09910	COG0081	regulation of translation
VY92_RS09915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VY92_RS09940	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VY92_RS09945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VY92_RS09975	COG2923	Belongs to the DsrF TusC family
VY92_RS09990	COG0545	Peptidyl-prolyl cis-trans isomerase
VY92_RS10000	COG0678	peroxiredoxin activity
VY92_RS10000	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VY92_RS10005	COG0583	DNA-binding transcription factor activity
VY92_RS10010	COG1309	transcriptional regulator
VY92_RS10015	COG2267	carboxylic ester hydrolase activity
VY92_RS10020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VY92_RS10035	COG3978	acetolactate synthase activity
VY92_RS10065	COG1476	TRANSCRIPTIONal
VY92_RS10085	COG3021	interspecies interaction between organisms
VY92_RS10095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VY92_RS10100	COG2818	Glycosylase
VY92_RS10105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VY92_RS10110	COG3477	response to acidic pH
VY92_RS10125	COG0538	isocitrate dehydrogenase activity
VY92_RS10145	COG4145	pantothenate transmembrane transporter activity
VY92_RS10150	COG3924	membrane
VY92_RS10160	COG0439	Biotin carboxylase
VY92_RS10185	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VY92_RS10215	COG3276	selenocysteine insertion sequence binding
VY92_RS10225	COG3171	Protein conserved in bacteria
VY92_RS10230	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VY92_RS10235	COG0606	chelatase, subunit chli
VY92_RS10240	COG0076	glutamate decarboxylase activity
VY92_RS10245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VY92_RS10250	COG3787	Belongs to the UPF0306 family
VY92_RS10255	COG3071	HemY protein
VY92_RS10260	COG2959	enzyme of heme biosynthesis
VY92_RS10270	COG0181	hydroxymethylbilane synthase activity
VY92_RS10280	COG2197	response regulator
VY92_RS10290	COG1295	ribonuclease BN
VY92_RS10300	COG1414	Transcriptional regulator
VY92_RS10305	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
VY92_RS10310	COG2731	YhcH YjgK YiaL family protein
VY92_RS10315	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VY92_RS10320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VY92_RS10325	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VY92_RS10335	COG3623	hexulose-6-phosphate isomerase
VY92_RS10340	COG0235	Class ii aldolase
VY92_RS10350	COG2884	Cell division ATP-binding protein ftsE
VY92_RS10355	COG2177	Part of the ABC transporter FtsEX involved in
VY92_RS10365	COG0762	integral membrane protein
VY92_RS10370	COG0598	Magnesium transport protein CorA
VY92_RS10380	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VY92_RS10405	COG3621	Patatin-like phospholipase
VY92_RS10425	COG4453	Protein conserved in bacteria
VY92_RS10680	COG0640	Transcriptional regulator
VY92_RS10695	COG0786	glutamate:sodium symporter activity
VY92_RS10710	COG3039	Transposase
VY92_RS10725	COG3039	Transposase
VY92_RS10770	COG0305	Participates in initiation and elongation during chromosome replication
VY92_RS10795	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VY92_RS10800	COG1194	a g-specific adenine glycosylase
VY92_RS10805	COG4213	ABC transporter substrate-binding protein
VY92_RS10810	COG1129	ABC transporter
VY92_RS10815	COG4214	carbohydrate transport
VY92_RS10830	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VY92_RS10845	COG3732	PTS system glucitol sorbitol-specific
VY92_RS10855	COG1028	Short-chain dehydrogenase reductase Sdr
VY92_RS10860	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY92_RS10865	COG1349	DNA-binding transcription factor activity
VY92_RS10880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VY92_RS10885	COG1757	Na H antiporter
VY92_RS10890	COG0436	Aminotransferase
VY92_RS10895	COG2115	Belongs to the xylose isomerase family
VY92_RS10900	COG1070	Carbohydrate kinase
VY92_RS10905	COG1609	Transcriptional regulator
VY92_RS10905	COG2207	Transcriptional regulator
VY92_RS10945	COG3070	regulator of competence-specific genes
VY92_RS10965	COG0551	DNA topoisomerase type I activity
VY92_RS10980	COG0733	neurotransmitter:sodium symporter activity
VY92_RS10990	COG1858	cytochrome C peroxidase
VY92_RS10995	COG1132	(ABC) transporter
VY92_RS11000	COG4988	ABC transporter
VY92_RS11010	COG0187	DNA topoisomerase II activity
VY92_RS11015	COG1494	fructose-1,6-bisphosphatase
VY92_RS11025	COG0716	FMN binding
VY92_RS11035	COG0357	Ribosomal RNA small subunit methyltransferase G
VY92_RS11060	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VY92_RS11070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VY92_RS11075	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VY92_RS11085	COG0483	inositol monophosphate 1-phosphatase activity
VY92_RS11090	COG2271	Major facilitator Superfamily
VY92_RS11125	COG1230	cation diffusion facilitator family transporter
VY92_RS11140	COG3153	acetyltransferase
VY92_RS11160	COG2195	Cleaves the N-terminal amino acid of tripeptides
VY92_RS11195	COG0019	diaminopimelate decarboxylase activity
VY92_RS11230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VY92_RS11240	COG3119	arylsulfatase activity
VY92_RS11250	COG0583	DNA-binding transcription factor activity
VY92_RS11260	COG3956	TIGRFAM MazG family protein
VY92_RS11275	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VY92_RS11285	COG1210	Utp--glucose-1-phosphate uridylyltransferase
VY92_RS11290	COG1114	Component of the transport system for branched-chain amino acids
VY92_RS11295	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VY92_RS11300	COG2095	MarC family integral membrane protein
VY92_RS11315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VY92_RS11375	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VY92_RS11395	COG0201	protein transport
VY92_RS11405	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VY92_RS11410	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VY92_RS11415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VY92_RS11420	COG0202	RNA polymerase activity
VY92_RS11425	COG0203	ribosomal protein L17
VY92_RS11435	COG2960	long-chain fatty acid transporting porin activity
VY92_RS11440	COG3172	ATPase kinase involved in NAD metabolism
VY92_RS11445	COG2129	metallophosphoesterase
VY92_RS11455	COG0582	viral genome integration into host DNA
VY92_RS11530	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VY92_RS11545	COG0732	type I restriction modification DNA specificity domain
VY92_RS11550	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VY92_RS11555	COG3056	Lipoprotein
VY92_RS11575	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VY92_RS11580	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VY92_RS11585	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VY92_RS11595	COG1477	protein flavinylation
VY92_RS11600	COG2991	Protein conserved in bacteria
VY92_RS11610	COG1519	Transferase
VY92_RS11620	COG0786	glutamate:sodium symporter activity
VY92_RS11650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VY92_RS11660	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VY92_RS11665	COG3068	Protein conserved in bacteria
VY92_RS11675	COG1349	DNA-binding transcription factor activity
VY92_RS11680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VY92_RS11690	COG0259	pyridoxamine-phosphate oxidase activity
VY92_RS11695	COG2814	Major facilitator Superfamily
VY92_RS11700	COG1763	Mo-molybdopterin cofactor biosynthetic process
VY92_RS11705	COG3086	response to oxidative stress
VY92_RS11710	COG3026	antisigma factor binding
VY92_RS11715	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
VY92_RS11720	COG1595	DNA-templated transcription, initiation
VY92_RS11735	COG2226	methyltransferase
VY92_RS11760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VY92_RS11765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VY92_RS11770	COG0493	'glutamate synthase
VY92_RS11775	COG0067	glutamate synthase
VY92_RS11775	COG0070	glutamate synthase
VY92_RS11775	COG0069	glutamate synthase activity
VY92_RS11785	COG0859	PFAM glycosyl transferase family 9
VY92_RS11790	COG1132	(ABC) transporter
VY92_RS11800	COG0549	Belongs to the carbamate kinase family
VY92_RS11810	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VY92_RS11820	COG1304	FMN binding
VY92_RS11825	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VY92_RS11835	COG0583	DNA-binding transcription factor activity
VY92_RS11845	COG1304	FMN binding
VY92_RS11850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VY92_RS11855	COG0666	response to abiotic stimulus
VY92_RS11880	COG0675	Transposase, IS605 OrfB family
VY92_RS11890	COG1126	abc transporter atp-binding protein
VY92_RS11895	COG0765	amino acid transport
VY92_RS11900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VY92_RS11905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VY92_RS11915	COG3078	GTPase activator activity
VY92_RS11920	COG0564	pseudouridine synthase activity
VY92_RS11930	COG3201	nicotinamide mononucleotide transporter
VY92_RS11935	COG0673	inositol 2-dehydrogenase activity
VY92_RS11940	COG3676	manually curated
VY92_RS11950	COG3718	enzyme involved in inositol metabolism
VY92_RS11965	COG0456	acetyltransferase
VY92_RS12000	COG0738	Major facilitator superfamily
VY92_RS12005	COG0235	Class ii aldolase
VY92_RS12015	COG1070	Carbohydrate kinase
VY92_RS12020	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
VY92_RS12025	COG1349	DNA-binding transcription factor activity
VY92_RS12035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VY92_RS12050	COG0859	PFAM glycosyl transferase family 9
VY92_RS12090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VY92_RS12105	COG3691	Protein conserved in bacteria
VY92_RS12110	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VY92_RS12115	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
VY92_RS12120	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
VY92_RS12125	COG0363	glucosamine-6-phosphate deaminase activity
VY92_RS12130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VY92_RS12135	COG1218	3'(2'),5'-bisphosphate nucleotidase
VY92_RS12140	COG1297	OPT oligopeptide transporter protein
VY92_RS12145	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VY92_RS12150	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VY92_RS12155	COG1609	Transcriptional regulator
VY92_RS12160	COG1917	Cupin 2, conserved barrel domain protein
VY92_RS12170	COG1070	Carbohydrate kinase
VY92_RS12175	COG1129	ABC transporter
VY92_RS12180	COG1172	Belongs to the binding-protein-dependent transport system permease family
VY92_RS12185	COG1879	ABC-type sugar transport system periplasmic component
VY92_RS12200	COG0051	transcription antitermination factor activity, RNA binding
VY92_RS12210	COG0088	Forms part of the polypeptide exit tunnel
VY92_RS12220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VY92_RS12225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VY92_RS12235	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VY92_RS12260	COG0582	viral genome integration into host DNA
VY92_RS12345	COG3728	DNA packaging