locus-tag	class	description
HBL79_RS00010	COG0594	ribonuclease P activity
HBL79_RS00020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HBL79_RS00025	COG0592	DNA-directed DNA polymerase activity
HBL79_RS00035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HBL79_RS00040	COG1381	Involved in DNA repair and RecF pathway recombination
HBL79_RS00045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HBL79_RS00050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HBL79_RS00055	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HBL79_RS00060	COG0252	asparaginase activity
HBL79_RS00070	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HBL79_RS00090	COG3133	Outer membrane lipoprotein
HBL79_RS00095	COG3962	Belongs to the TPP enzyme family
HBL79_RS00105	COG0673	inositol 2-dehydrogenase activity
HBL79_RS00115	COG0431	NADPH-dependent FMN reductase
HBL79_RS00125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HBL79_RS00135	COG3307	-O-antigen
HBL79_RS00140	COG2976	Protein conserved in bacteria
HBL79_RS00155	COG1426	Protein conserved in bacteria
HBL79_RS00160	COG0490	domain, Protein
HBL79_RS00160	COG0471	metal ion transport
HBL79_RS00165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HBL79_RS00175	COG4589	Belongs to the CDS family
HBL79_RS00180	COG0521	Mo-molybdopterin cofactor biosynthetic process
HBL79_RS00190	COG0628	permease
HBL79_RS00200	COG3063	Type IV pilus biogenesis stability protein PilW
HBL79_RS00205	COG0758	DNA mediated transformation
HBL79_RS00210	COG0742	ribosomal rna small subunit methyltransferase
HBL79_RS00215	COG0552	protein localization to endoplasmic reticulum
HBL79_RS00220	COG0584	glycerophosphoryl diester phosphodiesterase
HBL79_RS00225	COG2271	Major facilitator Superfamily
HBL79_RS00230	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HBL79_RS00240	COG0247	lactate metabolic process
HBL79_RS00245	COG1349	DNA-binding transcription factor activity
HBL79_RS00250	COG0705	Rhomboid family
HBL79_RS00260	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HBL79_RS00270	COG0546	phosphoglycolate phosphatase activity
HBL79_RS00275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HBL79_RS00285	COG0251	oxidation-reduction process
HBL79_RS00305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HBL79_RS00315	COG0512	Glutamine amidotransferase of anthranilate synthase
HBL79_RS00320	COG0783	Belongs to the Dps family
HBL79_RS00335	COG0196	riboflavin kinase activity
HBL79_RS00360	COG0745	RESPONSE REGULATOR receiver
HBL79_RS00365	COG0642	Histidine kinase
HBL79_RS00380	COG0165	Argininosuccinate lyase
HBL79_RS00385	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HBL79_RS00540	COG3566	protein conserved in bacteria
HBL79_RS00550	COG2369	cell adhesion
HBL79_RS00555	COG3567	Phage-associated protein, HI1409 family
HBL79_RS00560	COG1783	phage Terminase large subunit
HBL79_RS00565	COG3728	DNA packaging
HBL79_RS00615	COG3617	BRO family, N-terminal domain
HBL79_RS00630	COG1846	Transcriptional regulator
HBL79_RS00695	COG3728	DNA packaging
HBL79_RS00700	COG1783	phage Terminase large subunit
HBL79_RS00785	COG1598	PFAM Uncharacterised protein family UPF0150
HBL79_RS00975	COG4695	Portal protein
HBL79_RS01050	COG4974	Belongs to the 'phage' integrase family
HBL79_RS01055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HBL79_RS01060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HBL79_RS01065	COG0720	synthase
HBL79_RS01070	COG0602	queuosine metabolic process
HBL79_RS01100	COG1215	transferase activity, transferring glycosyl groups
HBL79_RS01150	COG1793	dna ligase
HBL79_RS01155	COG0363	glucosamine-6-phosphate deaminase activity
HBL79_RS01160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HBL79_RS01165	COG0590	tRNA wobble adenosine to inosine editing
HBL79_RS01180	COG0730	response to heat
HBL79_RS01185	COG0494	nUDIX hydrolase
HBL79_RS01195	COG3023	N-Acetylmuramoyl-L-alanine amidase
HBL79_RS01200	COG4969	Belongs to the N-Me-Phe pilin family
HBL79_RS01205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HBL79_RS01210	COG0528	UMP kinase activity
HBL79_RS01230	COG0575	Belongs to the CDS family
HBL79_RS01235	COG0750	zinc metalloprotease
HBL79_RS01245	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HBL79_RS01250	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HBL79_RS01255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HBL79_RS01270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HBL79_RS01280	COG1466	dna polymerase III delta subunit
HBL79_RS01285	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HBL79_RS01290	COG0495	leucyl-tRNA aminoacylation
HBL79_RS01310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HBL79_RS01315	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HBL79_RS01320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HBL79_RS01355	COG0328	RNA-DNA hybrid ribonuclease activity
HBL79_RS01370	COG3716	PTS system mannose fructose sorbose family IID component
HBL79_RS01375	COG3715	PTS system
HBL79_RS01380	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HBL79_RS01380	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HBL79_RS01385	COG1459	type II secretion system
HBL79_RS01395	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HBL79_RS01395	COG0237	dephospho-CoA kinase activity
HBL79_RS01405	COG1115	amino acid carrier protein
HBL79_RS01410	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HBL79_RS01415	COG1917	Cupin 2, conserved barrel domain protein
HBL79_RS01415	COG4977	sequence-specific DNA binding
HBL79_RS01420	COG5413	integral membrane protein
HBL79_RS01430	COG4178	(ABC) transporter
HBL79_RS01440	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HBL79_RS01455	COG1454	alcohol dehydrogenase
HBL79_RS01455	COG1012	belongs to the aldehyde dehydrogenase family
HBL79_RS01460	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HBL79_RS01465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HBL79_RS01475	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HBL79_RS01480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBL79_RS01485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HBL79_RS01490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HBL79_RS01525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HBL79_RS01535	COG2990	Protein conserved in bacteria
HBL79_RS01540	COG0612	Peptidase, M16
HBL79_RS01555	COG0539	negative regulation of cytoplasmic translation
HBL79_RS01560	COG0776	regulation of translation
HBL79_RS01565	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HBL79_RS01570	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HBL79_RS01580	COG0023	Translation Initiation Factor
HBL79_RS01600	COG0745	RESPONSE REGULATOR receiver
HBL79_RS01605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HBL79_RS01610	COG0151	Belongs to the GarS family
HBL79_RS01625	COG2259	Doxx family
HBL79_RS01630	COG5295	Hep Hag repeat protein
HBL79_RS01645	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HBL79_RS01650	COG4172	Belongs to the ABC transporter superfamily
HBL79_RS01655	COG4172	Belongs to the ABC transporter superfamily
HBL79_RS01665	COG4168	peptide transport system, permease
HBL79_RS01670	COG4166	transmembrane transport
HBL79_RS01675	COG3106	COG3106 Predicted ATPase
HBL79_RS01685	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HBL79_RS01700	COG0012	GTP binding
HBL79_RS01710	COG2867	negative regulation of translational initiation
HBL79_RS01720	COG2850	peptidyl-arginine hydroxylation
HBL79_RS01735	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HBL79_RS01740	COG0739	heme binding
HBL79_RS01750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HBL79_RS01755	COG0443	Heat shock 70 kDa protein
HBL79_RS01760	COG0484	heat shock protein binding
HBL79_RS01770	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HBL79_RS01775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HBL79_RS01780	COG1643	Atp-dependent helicase
HBL79_RS01790	COG0471	metal ion transport
HBL79_RS01800	COG0583	DNA-binding transcription factor activity
HBL79_RS01805	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HBL79_RS01810	COG1687	branched-chain amino acid
HBL79_RS01830	COG2864	formate dehydrogenase
HBL79_RS01835	COG0437	4 iron, 4 sulfur cluster binding
HBL79_RS01855	COG2217	Heavy metal translocating P-type atpase
HBL79_RS01865	COG0531	amino acid
HBL79_RS01870	COG1982	Orn Lys Arg decarboxylase major
HBL79_RS01960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBL79_RS01970	COG3021	interspecies interaction between organisms
HBL79_RS01975	COG0251	oxidation-reduction process
HBL79_RS02000	COG0270	DNA (cytosine-5-)-methyltransferase activity
HBL79_RS02045	COG2974	May be involved in recombination
HBL79_RS02125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HBL79_RS02150	COG1484	DNA-dependent DNA replication
HBL79_RS02335	COG3179	chitinase
HBL79_RS02365	COG3646	Phage regulatory protein
HBL79_RS02400	COG0582	viral genome integration into host DNA
HBL79_RS02405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HBL79_RS02405	COG0519	Catalyzes the synthesis of GMP from XMP
HBL79_RS02420	COG0516	GMP reductase activity
HBL79_RS02420	COG0517	IMP dehydrogenase activity
HBL79_RS02425	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HBL79_RS02425	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HBL79_RS02435	COG3422	double-strand break repair
HBL79_RS02450	COG0134	indole-3-glycerol-phosphate synthase activity
HBL79_RS02450	COG0135	phosphoribosylanthranilate isomerase activity
HBL79_RS02455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HBL79_RS02460	COG1942	4-Oxalocrotonate Tautomerase
HBL79_RS02465	COG0512	Glutamine amidotransferase of anthranilate synthase
HBL79_RS02470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HBL79_RS02480	COG2927	DNA polymerase III (CHI subunit)
HBL79_RS02485	COG2153	protein acetylation
HBL79_RS02495	COG4185	zeta toxin
HBL79_RS02510	COG0525	valine-tRNA ligase activity
HBL79_RS02515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HBL79_RS02520	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBL79_RS02535	COG2814	Major facilitator Superfamily
HBL79_RS02555	COG4221	oxidoreductase activity
HBL79_RS02570	COG3094	Invasion gene expression up-regulator, SirB
HBL79_RS02575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HBL79_RS02585	COG0735	belongs to the Fur family
HBL79_RS02590	COG0716	FMN binding
HBL79_RS02600	COG0596	Alpha beta hydrolase
HBL79_RS02605	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HBL79_RS02610	COG0318	PFAM AMP-dependent synthetase and ligase
HBL79_RS02615	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HBL79_RS02615	COG3264	Mechanosensitive ion channel
HBL79_RS02625	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HBL79_RS02630	COG0730	response to heat
HBL79_RS02635	COG1560	Kdo2-lipid A biosynthetic process
HBL79_RS02640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HBL79_RS02645	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HBL79_RS02650	COG1966	Carbon starvation protein
HBL79_RS02655	COG0673	inositol 2-dehydrogenase activity
HBL79_RS02660	COG2186	Transcriptional regulator
HBL79_RS02665	COG3842	ATPase activity
HBL79_RS02675	COG1175	transmembrane transport
HBL79_RS02685	COG0673	inositol 2-dehydrogenase activity
HBL79_RS02695	COG0281	malic enzyme
HBL79_RS02700	COG1733	regulation of RNA biosynthetic process
HBL79_RS02710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HBL79_RS02715	COG1177	transmembrane transport
HBL79_RS02720	COG1176	ABC-type spermidine putrescine transport system, permease component I
HBL79_RS02725	COG3842	ATPase activity
HBL79_RS02735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HBL79_RS02740	COG4143	(ABC) transporter
HBL79_RS02745	COG1178	ABC-type Fe3 transport system permease component
HBL79_RS02750	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HBL79_RS02760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HBL79_RS02765	COG0730	response to heat
HBL79_RS02780	COG0786	glutamate:sodium symporter activity
HBL79_RS02785	COG2005	Transcriptional regulator
HBL79_RS02790	COG0725	ABC transporter, periplasmic molybdate-binding protein
HBL79_RS02795	COG4149	molybdate abc transporter
HBL79_RS02800	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HBL79_RS02810	COG3102	Protein conserved in bacteria
HBL79_RS02815	COG0305	Participates in initiation and elongation during chromosome replication
HBL79_RS02835	COG2932	Transcriptional regulator
HBL79_RS02870	COG3077	Addiction module antitoxin, RelB DinJ family
HBL79_RS02875	COG3041	Addiction module toxin RelE StbE family
HBL79_RS02885	COG0494	nUDIX hydrolase
HBL79_RS02910	COG1929	Belongs to the glycerate kinase type-1 family
HBL79_RS02915	COG2610	gluconate transmembrane transporter activity
HBL79_RS02920	COG3835	regulator
HBL79_RS02925	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HBL79_RS02930	COG1448	Aminotransferase
HBL79_RS02935	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HBL79_RS02940	COG0288	reversible hydration of carbon dioxide
HBL79_RS02945	COG0306	phosphate transporter
HBL79_RS02950	COG1392	Phosphate transport regulator
HBL79_RS02955	COG3025	triphosphatase activity
HBL79_RS02960	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HBL79_RS02965	COG3266	domain, Protein
HBL79_RS02965	COG3468	outer membrane autotransporter barrel domain protein
HBL79_RS02975	COG0352	thiamine-phosphate diphosphorylase activity
HBL79_RS02980	COG0351	phosphomethylpyrimidine kinase
HBL79_RS02995	COG1132	(ABC) transporter
HBL79_RS03000	COG1663	tetraacyldisaccharide 4'-kinase activity
HBL79_RS03005	COG2835	tetraacyldisaccharide 4'-kinase activity
HBL79_RS03010	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HBL79_RS03015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBL79_RS03020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBL79_RS03025	COG1116	anion transmembrane transporter activity
HBL79_RS03030	COG0322	excinuclease ABC activity
HBL79_RS03035	COG0586	Pfam SNARE associated Golgi protein
HBL79_RS03040	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HBL79_RS03045	COG0673	inositol 2-dehydrogenase activity
HBL79_RS03055	COG0307	riboflavin synthase, alpha
HBL79_RS03085	COG0671	phosphoesterase, PA-phosphatase related
HBL79_RS03090	COG1940	carbohydrate kinase activity
HBL79_RS03105	COG1115	amino acid carrier protein
HBL79_RS03110	COG0515	serine threonine protein kinase
HBL79_RS03125	COG0195	Participates in both transcription termination and antitermination
HBL79_RS03130	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HBL79_RS03140	COG1566	PFAM secretion protein HlyD family protein
HBL79_RS03160	COG2350	Protein conserved in bacteria
HBL79_RS03165	COG1607	acyl-coa hydrolase
HBL79_RS03180	COG3047	cAMP biosynthetic process
HBL79_RS03195	COG0277	FAD linked oxidase domain protein
HBL79_RS03195	COG0247	lactate metabolic process
HBL79_RS03205	COG1704	LemA family
HBL79_RS03255	COG1530	ribonuclease E activity
HBL79_RS03280	COG2965	DNA replication, synthesis of RNA primer
HBL79_RS03285	COG0360	Binds together with S18 to 16S ribosomal RNA
HBL79_RS03290	COG0497	DNA recombination
HBL79_RS03305	COG1846	Transcriptional regulator
HBL79_RS03305	COG1940	carbohydrate kinase activity
HBL79_RS03335	COG0330	HflC and HflK could
HBL79_RS03345	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBL79_RS03350	COG3381	protein complex oligomerization
HBL79_RS03355	COG0372	Belongs to the citrate synthase family
HBL79_RS03360	COG0567	Dehydrogenase, E1 component
HBL79_RS03365	COG0508	dehydrogenase complex catalyzes the overall conversion of
HBL79_RS03375	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HBL79_RS03380	COG0037	tRNA processing
HBL79_RS03390	COG0778	Nitroreductase
HBL79_RS03395	COG0469	pyruvate kinase activity
HBL79_RS03405	COG2964	Protein conserved in bacteria
HBL79_RS03410	COG0814	amino acid
HBL79_RS03420	COG4774	siderophore transport
HBL79_RS03425	COG4774	siderophore transport
HBL79_RS03430	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
HBL79_RS03450	COG1120	ATPase activity
HBL79_RS03455	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HBL79_RS03460	COG2824	Alkylphosphonate utilization operon protein PhnA
HBL79_RS03465	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HBL79_RS03465	COG2885	chlorophyll binding
HBL79_RS03470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HBL79_RS03475	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HBL79_RS03480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBL79_RS03490	COG3177	Filamentation induced by cAMP protein fic
HBL79_RS03505	COG0676	glucose-6-phosphate 1-epimerase activity
HBL79_RS03510	COG1136	(ABC) transporter
HBL79_RS03520	COG0577	efflux transmembrane transporter activity
HBL79_RS03520	COG1136	(ABC) transporter
HBL79_RS03535	COG0672	)-iron permease
HBL79_RS03540	COG0489	protein tyrosine kinase activity
HBL79_RS03545	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBL79_RS03545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBL79_RS03550	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HBL79_RS03550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HBL79_RS03555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HBL79_RS03560	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HBL79_RS03565	COG5039	Polysaccharide pyruvyl transferase
HBL79_RS03575	COG3306	glycosyltransferase involved in LPS biosynthesis
HBL79_RS03585	COG1216	Glycosyl transferase, family 2
HBL79_RS03590	COG1216	Glycosyl transferase, family 2
HBL79_RS03595	COG2951	lytic endotransglycosylase activity
HBL79_RS03600	COG1741	Belongs to the pirin family
HBL79_RS03615	COG2378	regulation of single-species biofilm formation
HBL79_RS03650	COG4735	regulation of single-species biofilm formation
HBL79_RS03675	COG3099	Belongs to the UPF0263 family
HBL79_RS03685	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HBL79_RS03690	COG1923	regulation of RNA biosynthetic process
HBL79_RS03700	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HBL79_RS03705	COG0860	N-Acetylmuramoyl-L-alanine amidase
HBL79_RS03705	COG1388	LysM domain
HBL79_RS03725	COG1621	beta-fructofuranosidase activity
HBL79_RS03735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HBL79_RS03750	COG2089	acid synthase
HBL79_RS03775	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HBL79_RS03780	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HBL79_RS03790	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HBL79_RS03795	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HBL79_RS03805	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HBL79_RS03810	COG0745	RESPONSE REGULATOR receiver
HBL79_RS03815	COG0642	Histidine kinase
HBL79_RS03820	COG0583	DNA-binding transcription factor activity
HBL79_RS03830	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HBL79_RS03855	COG3210	domain, Protein
HBL79_RS03880	COG2814	Major facilitator Superfamily
HBL79_RS03885	COG4221	oxidoreductase activity
HBL79_RS03900	COG0741	lytic transglycosylase activity
HBL79_RS03905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HBL79_RS03910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HBL79_RS03915	COG1862	Preprotein translocase
HBL79_RS03920	COG3945	hemerythrin HHE cation binding domain
HBL79_RS03935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HBL79_RS03940	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HBL79_RS03940	COG0506	proline dehydrogenase activity
HBL79_RS03940	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HBL79_RS03945	COG2056	Na+-H+ antiporter family
HBL79_RS03950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HBL79_RS03955	COG0346	lactoylglutathione lyase activity
HBL79_RS03965	COG0527	aspartate kinase activity
HBL79_RS03965	COG0460	homoserine dehydrogenase
HBL79_RS03970	COG0083	homoserine kinase activity
HBL79_RS03975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HBL79_RS03995	COG1393	Belongs to the ArsC family
HBL79_RS04000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HBL79_RS04005	COG1876	peptidase activity
HBL79_RS04015	COG0494	nUDIX hydrolase
HBL79_RS04020	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HBL79_RS04045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBL79_RS04070	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HBL79_RS04085	COG1757	Na H antiporter
HBL79_RS04090	COG0028	Belongs to the TPP enzyme family
HBL79_RS04095	COG0440	acetolactate synthase activity
HBL79_RS04100	COG0039	L-malate dehydrogenase activity
HBL79_RS04120	COG0778	Nitroreductase
HBL79_RS04125	COG0616	signal peptide processing
HBL79_RS04130	COG0583	DNA-binding transcription factor activity
HBL79_RS04155	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HBL79_RS04160	COG1328	CTP reductase activity
HBL79_RS04165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HBL79_RS04175	COG0187	DNA topoisomerase II activity
HBL79_RS04180	COG3008	intermembrane lipid transfer
HBL79_RS04185	COG2995	paraquat-inducible protein a
HBL79_RS04190	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HBL79_RS04195	COG0793	Belongs to the peptidase S41A family
HBL79_RS04200	COG2989	Protein conserved in bacteria
HBL79_RS04205	COG3108	Peptidase M15
HBL79_RS04210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBL79_RS04215	COG1560	Kdo2-lipid A biosynthetic process
HBL79_RS04220	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HBL79_RS04220	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HBL79_RS04225	COG3100	YcgL domain-containing protein
HBL79_RS04230	COG0450	alkyl hydroperoxide reductase
HBL79_RS04235	COG0626	cystathionine gamma-synthase activity
HBL79_RS04250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HBL79_RS04255	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HBL79_RS04270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HBL79_RS04275	COG0583	DNA-binding transcription factor activity
HBL79_RS04295	COG0210	DNA helicase
HBL79_RS04300	COG2823	Periplasmic or secreted lipoprotein
HBL79_RS04305	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HBL79_RS04310	COG0792	nuclease activity
HBL79_RS04325	COG0009	L-threonylcarbamoyladenylate synthase
HBL79_RS04335	COG0583	DNA-binding transcription factor activity
HBL79_RS04340	COG2171	N-acyltransferase activity
HBL79_RS04350	COG0589	response to stress
HBL79_RS04355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HBL79_RS04365	COG1528	Iron-storage protein
HBL79_RS04370	COG1528	Iron-storage protein
HBL79_RS04375	COG2431	L-lysine efflux transmembrane transporter activity
HBL79_RS04380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HBL79_RS04385	COG0303	'Molybdopterin
HBL79_RS04395	COG1696	Membrane protein involved in D-alanine export
HBL79_RS04440	COG0315	cyclic pyranopterin monophosphate synthase activity
HBL79_RS04445	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HBL79_RS04450	COG0314	molybdopterin synthase activity
HBL79_RS04465	COG1289	transmembrane transporter activity
HBL79_RS04475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBL79_RS04495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HBL79_RS04500	COG4591	ABC-type transport system involved in lipoprotein release permease component
HBL79_RS04505	COG1136	(ABC) transporter
HBL79_RS04510	COG4591	ABC-type transport system involved in lipoprotein release permease component
HBL79_RS04515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HBL79_RS04525	COG2949	membrane
HBL79_RS04530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HBL79_RS04535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HBL79_RS04540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HBL79_RS04545	COG1121	(ABC) transporter
HBL79_RS04555	COG2920	part of a sulfur-relay system
HBL79_RS04560	COG0670	Belongs to the BI1 family
HBL79_RS04565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HBL79_RS04570	COG1957	nucleoside hydrolase
HBL79_RS04575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HBL79_RS04580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HBL79_RS04595	COG2195	Cleaves the N-terminal amino acid of tripeptides
HBL79_RS04600	COG0488	(ABC) transporter
HBL79_RS04605	COG3683	transport system, periplasmic component
HBL79_RS04610	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HBL79_RS04630	COG3306	glycosyltransferase involved in LPS biosynthesis
HBL79_RS04635	COG3306	glycosyltransferase involved in LPS biosynthesis
HBL79_RS04655	COG0582	viral genome integration into host DNA
HBL79_RS04660	COG1476	TRANSCRIPTIONal
HBL79_RS04695	COG2999	glutathione oxidoreductase activity
HBL79_RS04735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HBL79_RS04740	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HBL79_RS04740	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HBL79_RS04745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HBL79_RS04755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HBL79_RS04765	COG2062	phosphohistidine phosphatase, SixA
HBL79_RS04775	COG0814	amino acid
HBL79_RS04785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HBL79_RS04790	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HBL79_RS04795	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HBL79_RS04800	COG1280	lysine exporter protein (LysE YggA)
HBL79_RS04810	COG0633	Ferredoxin
HBL79_RS04825	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HBL79_RS04830	COG3105	Protein conserved in bacteria
HBL79_RS04835	COG1944	ATP diphosphatase activity
HBL79_RS04840	COG2226	methyltransferase
HBL79_RS04845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBL79_RS04870	COG0795	lipopolysaccharide-transporting ATPase activity
HBL79_RS04875	COG0795	lipopolysaccharide-transporting ATPase activity
HBL79_RS04880	COG0668	transmembrane transport
HBL79_RS04905	COG0280	phosphate acetyltransferase
HBL79_RS04905	COG0857	belongs to the CobB CobQ family
HBL79_RS04915	COG3092	negative regulation of chromosome organization
HBL79_RS04920	COG1286	toxin biosynthetic process
HBL79_RS04930	COG0163	prenyltransferase activity
HBL79_RS04975	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HBL79_RS04980	COG0308	aminopeptidase N
HBL79_RS04985	COG0167	dihydroorotate dehydrogenase activity
HBL79_RS04990	COG0613	PHP domain protein
HBL79_RS04995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HBL79_RS05000	COG1605	Chorismate mutase
HBL79_RS05000	COG0287	Prephenate dehydrogenase
HBL79_RS05010	COG3217	Mosc domain protein beta barrel domain protein
HBL79_RS05010	COG0633	Ferredoxin
HBL79_RS05020	COG1534	Rna-binding protein
HBL79_RS05030	COG0142	geranyltranstransferase activity
HBL79_RS05040	COG0301	tRNA thio-modification
HBL79_RS05040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HBL79_RS05045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HBL79_RS05050	COG0617	tRNA 3'-terminal CCA addition
HBL79_RS05055	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HBL79_RS05065	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HBL79_RS05065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HBL79_RS05070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HBL79_RS05085	COG2268	Band 7 protein
HBL79_RS05090	COG2166	iron-sulfur cluster assembly
HBL79_RS05100	COG1525	nuclease
HBL79_RS05105	COG1380	Effector of murein hydrolase LrgA
HBL79_RS05110	COG1346	cytolysis
HBL79_RS05120	COG1522	sequence-specific DNA binding
HBL79_RS05145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HBL79_RS05150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HBL79_RS05170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HBL79_RS05175	COG1162	GTPase activity
HBL79_RS05180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HBL79_RS05185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HBL79_RS05190	COG2190	(PTS) system
HBL79_RS05195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HBL79_RS05200	COG0508	dehydrogenase complex catalyzes the overall conversion of
HBL79_RS05205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBL79_RS05215	COG1538	Outer membrane efflux protein
HBL79_RS05220	COG1136	(ABC) transporter
HBL79_RS05220	COG0577	efflux transmembrane transporter activity
HBL79_RS05240	COG3152	Membrane
HBL79_RS05245	COG1640	4-alpha-glucanotransferase
HBL79_RS05250	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HBL79_RS05255	COG1523	belongs to the glycosyl hydrolase 13 family
HBL79_RS05275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HBL79_RS05285	COG3101	peptidyl-lysine hydroxylation
HBL79_RS05290	COG1131	(ABC) transporter
HBL79_RS05295	COG0842	Transport permease protein
HBL79_RS05300	COG1215	transferase activity, transferring glycosyl groups
HBL79_RS05310	COG4453	Protein conserved in bacteria
HBL79_RS05315	COG1611	Belongs to the LOG family
HBL79_RS05330	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HBL79_RS05335	COG3098	single-species biofilm formation
HBL79_RS05360	COG2969	positive regulation of protein catabolic process
HBL79_RS05365	COG3676	manually curated
HBL79_RS05380	COG2925	Exonuclease
HBL79_RS05385	COG0697	spore germination
HBL79_RS05420	COG0791	NLP P60 protein
HBL79_RS05425	COG0776	regulation of translation
HBL79_RS05440	COG0564	pseudouridine synthase activity
HBL79_RS05450	COG0406	alpha-ribazole phosphatase activity
HBL79_RS05455	COG0788	formyltetrahydrofolate deformylase activity
HBL79_RS05465	COG1846	Transcriptional regulator
HBL79_RS05465	COG1940	carbohydrate kinase activity
HBL79_RS05485	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HBL79_RS05490	COG1074	ATP-dependent DNA helicase activity
HBL79_RS05495	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HBL79_RS05500	COG2252	PERMEase
HBL79_RS05505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HBL79_RS05510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HBL79_RS05520	COG1067	ATP-dependent peptidase activity
HBL79_RS05535	COG1609	Transcriptional regulator
HBL79_RS05550	COG1278	Cold shock
HBL79_RS05555	COG3140	Belongs to the UPF0181 family
HBL79_RS05560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HBL79_RS05565	COG0285	dihydrofolate synthase activity
HBL79_RS05595	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HBL79_RS05595	COG0517	IMP dehydrogenase activity
HBL79_RS05600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HBL79_RS05610	COG0039	L-malate dehydrogenase activity
HBL79_RS05615	COG1438	arginine binding
HBL79_RS05620	COG1090	epimerase
HBL79_RS05625	COG4657	Part of a membrane complex involved in electron transport
HBL79_RS05635	COG4656	Part of a membrane complex involved in electron transport
HBL79_RS05640	COG4658	electron transport chain
HBL79_RS05655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HBL79_RS05660	COG0733	neurotransmitter:sodium symporter activity
HBL79_RS05670	COG3265	gluconokinase activity
HBL79_RS05675	COG2610	gluconate transmembrane transporter activity
HBL79_RS05680	COG3118	belongs to the thioredoxin family
HBL79_RS05685	COG0492	ferredoxin-NADP+ reductase activity
HBL79_RS05690	COG4988	ABC transporter
HBL79_RS05695	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HBL79_RS05710	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HBL79_RS05715	COG0318	PFAM AMP-dependent synthetase and ligase
HBL79_RS05720	COG1214	PFAM Peptidase M22, glycoprotease
HBL79_RS05725	COG1199	ATP-dependent helicase activity
HBL79_RS05735	COG2863	cytochrome
HBL79_RS05740	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HBL79_RS05745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HBL79_RS05750	COG1408	metallophosphoesterase
HBL79_RS05755	COG1840	ABC-type Fe3 transport system, periplasmic component
HBL79_RS05775	COG0708	Exodeoxyribonuclease III
HBL79_RS05785	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HBL79_RS05800	COG1914	H( )-stimulated, divalent metal cation uptake system
HBL79_RS05805	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HBL79_RS05810	COG1984	allophanate hydrolase subunit 2
HBL79_RS05815	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HBL79_RS05820	COG3955	Domain of unknown function (DUF1919)
HBL79_RS05825	COG0617	tRNA 3'-terminal CCA addition
HBL79_RS05830	COG4991	sh3 domain protein
HBL79_RS05885	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HBL79_RS05895	COG0024	Methionine aminopeptidase
HBL79_RS05900	COG0316	Belongs to the HesB IscA family
HBL79_RS05910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HBL79_RS05920	COG4166	transmembrane transport
HBL79_RS05925	COG2832	Protein of unknown function (DUF454)
HBL79_RS05930	COG0339	signal peptide processing
HBL79_RS05935	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HBL79_RS05940	COG1053	succinate dehydrogenase
HBL79_RS05945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HBL79_RS05955	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HBL79_RS05965	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HBL79_RS05970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HBL79_RS05975	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HBL79_RS05990	COG1278	Cold shock
HBL79_RS05995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HBL79_RS06005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HBL79_RS06010	COG5007	Belongs to the BolA IbaG family
HBL79_RS06015	COG3113	response to antibiotic
HBL79_RS06020	COG2854	intermembrane phospholipid transfer
HBL79_RS06025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HBL79_RS06030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HBL79_RS06035	COG1127	ABC transporter
HBL79_RS06045	COG3117	lipopolysaccharide transmembrane transporter activity
HBL79_RS06050	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HBL79_RS06055	COG1137	ATPase activity
HBL79_RS06060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HBL79_RS06075	COG2186	Transcriptional regulator
HBL79_RS06090	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HBL79_RS06100	COG1028	Short-chain dehydrogenase reductase Sdr
HBL79_RS06150	COG2267	carboxylic ester hydrolase activity
HBL79_RS06165	COG0436	Aminotransferase
HBL79_RS06185	COG0861	Integral membrane protein TerC family
HBL79_RS06195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HBL79_RS06200	COG2067	long-chain fatty acid transport protein
HBL79_RS06210	COG2860	membrane
HBL79_RS06220	COG0527	aspartate kinase activity
HBL79_RS06225	COG2897	thiosulfate sulfurtransferase activity
HBL79_RS06230	COG2391	methyltransferase activity
HBL79_RS06235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HBL79_RS06250	COG3684	Belongs to the aldolase LacD family
HBL79_RS06255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HBL79_RS06260	COG1349	DNA-binding transcription factor activity
HBL79_RS06270	COG3119	arylsulfatase activity
HBL79_RS06275	COG0641	radical SAM
HBL79_RS06285	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HBL79_RS06290	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HBL79_RS06290	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HBL79_RS06295	COG3716	PTS system mannose fructose sorbose family IID component
HBL79_RS06300	COG3715	PTS system
HBL79_RS06305	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HBL79_RS06310	COG2222	sugar isomerase
HBL79_RS06320	COG3119	arylsulfatase activity
HBL79_RS06330	COG1028	Short-chain dehydrogenase reductase Sdr
HBL79_RS06340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HBL79_RS06345	COG0800	Aldolase
HBL79_RS06350	COG0584	glycerophosphoryl diester phosphodiesterase
HBL79_RS06355	COG3842	ATPase activity
HBL79_RS06365	COG1177	transmembrane transport
HBL79_RS06390	COG1509	lysine 2,3-aminomutase activity
HBL79_RS06395	COG3266	domain, Protein
HBL79_RS06395	COG3061	Opacity-associated protein A
HBL79_RS06405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HBL79_RS06410	COG2814	Major facilitator Superfamily
HBL79_RS06415	COG4974	Belongs to the 'phage' integrase family
HBL79_RS06420	COG1605	Chorismate mutase
HBL79_RS06420	COG0077	Prephenate dehydratase
HBL79_RS06425	COG1028	Short-chain dehydrogenase reductase Sdr
HBL79_RS06425	COG0604	alcohol dehydrogenase
HBL79_RS06425	COG3321	synthase
HBL79_RS06440	COG4221	oxidoreductase activity
HBL79_RS06455	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HBL79_RS06460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HBL79_RS06465	COG0849	cell division
HBL79_RS06470	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HBL79_RS06495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HBL79_RS06505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HBL79_RS06515	COG0768	penicillin binding
HBL79_RS06520	COG3116	cell division
HBL79_RS06540	COG1444	tRNA N-acetyltransferase activity
HBL79_RS06550	COG1702	phosphate starvation-inducible protein PhoH
HBL79_RS06560	COG0204	Acyl-transferase
HBL79_RS06570	COG0121	glutamine amidotransferase
HBL79_RS06575	COG0814	amino acid
HBL79_RS06580	COG1760	l-serine dehydratase
HBL79_RS06585	COG1138	Cytochrome C-type biogenesis protein
HBL79_RS06595	COG4235	cytochrome complex assembly
HBL79_RS06595	COG3088	subunit of a heme lyase
HBL79_RS06600	COG4235	cytochrome complex assembly
HBL79_RS06600	COG3088	subunit of a heme lyase
HBL79_RS06605	COG2081	HI0933 family
HBL79_RS06615	COG3301	Polysulphide reductase, NrfD
HBL79_RS06620	COG0437	4 iron, 4 sulfur cluster binding
HBL79_RS06625	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HBL79_RS06630	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HBL79_RS06650	COG1686	Belongs to the peptidase S11 family
HBL79_RS06660	COG0772	Belongs to the SEDS family
HBL79_RS06665	COG0768	penicillin binding
HBL79_RS06675	COG0799	negative regulation of ribosome biogenesis
HBL79_RS06680	COG0513	Belongs to the DEAD box helicase family
HBL79_RS06685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HBL79_RS06715	COG3842	ATPase activity
HBL79_RS06745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HBL79_RS06750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HBL79_RS06760	COG0194	GDP metabolic process
HBL79_RS06765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HBL79_RS06770	COG3676	manually curated
HBL79_RS06775	COG0545	Peptidyl-prolyl cis-trans isomerase
HBL79_RS06795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HBL79_RS06805	COG2830	Protein of unknown function (DUF452)
HBL79_RS06810	COG0500	methyltransferase
HBL79_RS06815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HBL79_RS06820	COG1399	metal-binding, possibly nucleic acid-binding protein
HBL79_RS06830	COG0416	fatty acid biosynthetic process
HBL79_RS06835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HBL79_RS06840	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HBL79_RS06845	COG1028	Short-chain dehydrogenase reductase Sdr
HBL79_RS06860	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HBL79_RS06870	COG0656	L-ascorbic acid biosynthetic process
HBL79_RS06940	COG1077	Cell shape determining protein MreB Mrl
HBL79_RS06945	COG1792	Involved in formation and maintenance of cell shape
HBL79_RS06950	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HBL79_RS06955	COG0748	coenzyme F420 binding
HBL79_RS06960	COG3721	Heme iron utilization protein
HBL79_RS06965	COG4771	TonB-dependent receptor
HBL79_RS06985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HBL79_RS06995	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HBL79_RS07005	COG2731	YhcH YjgK YiaL family protein
HBL79_RS07010	COG1737	Transcriptional regulator
HBL79_RS07020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HBL79_RS07040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HBL79_RS07065	COG1172	Belongs to the binding-protein-dependent transport system permease family
HBL79_RS07070	COG1129	ABC transporter
HBL79_RS07080	COG1879	ABC-type sugar transport system periplasmic component
HBL79_RS07085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBL79_RS07090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBL79_RS07095	COG0006	proline dipeptidase activity
HBL79_RS07115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HBL79_RS07120	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HBL79_RS07125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HBL79_RS07130	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HBL79_RS07135	COG1720	tRNA m6t6A37 methyltransferase activity
HBL79_RS07140	COG1575	Belongs to the MenA family. Type 1 subfamily
HBL79_RS07145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HBL79_RS07150	COG0471	metal ion transport
HBL79_RS07155	COG2226	methyltransferase
HBL79_RS07165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HBL79_RS07175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HBL79_RS07180	COG0805	protein transport
HBL79_RS07190	COG0084	hydrolase, TatD family'
HBL79_RS07195	COG0602	queuosine metabolic process
HBL79_RS07200	COG1328	CTP reductase activity
HBL79_RS07200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HBL79_RS07205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HBL79_RS07220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HBL79_RS07280	COG2026	Addiction module toxin, RelE StbE family
HBL79_RS07310	COG0582	viral genome integration into host DNA
HBL79_RS07335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HBL79_RS07340	COG0494	nUDIX hydrolase
HBL79_RS07345	COG0653	protein targeting
HBL79_RS07355	COG4701	Protein of unknown function (DUF721)
HBL79_RS07360	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HBL79_RS07365	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HBL79_RS07375	COG4796	Type ii and iii secretion system protein
HBL79_RS07395	COG4972	Pilus assembly protein
HBL79_RS07400	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HBL79_RS07405	COG3676	manually curated
HBL79_RS07430	COG2852	Protein conserved in bacteria
HBL79_RS07435	COG4804	nuclease activity
HBL79_RS07445	COG4545	Glutaredoxin-related protein
HBL79_RS07450	COG0752	glycyl-tRNA synthetase alpha subunit
HBL79_RS07480	COG0582	viral genome integration into host DNA
HBL79_RS07490	COG3617	BRO family, N-terminal domain
HBL79_RS07515	COG0629	single-stranded DNA binding
HBL79_RS07660	COG1846	Transcriptional regulator
HBL79_RS07685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HBL79_RS07765	COG2974	May be involved in recombination
HBL79_RS07810	COG0582	viral genome integration into host DNA
HBL79_RS07830	COG0626	cystathionine gamma-synthase activity
HBL79_RS07835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HBL79_RS07845	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HBL79_RS07850	COG0142	geranyltranstransferase activity
HBL79_RS07865	COG0697	spore germination
HBL79_RS07970	COG3210	domain, Protein
HBL79_RS07970	COG3210	domain, Protein
HBL79_RS07975	COG2831	hemolysin activation secretion protein
HBL79_RS07985	COG1846	Transcriptional regulator
HBL79_RS08000	COG1846	Transcriptional regulator
HBL79_RS08005	COG1566	PFAM secretion protein HlyD family protein
HBL79_RS08010	COG2814	Major facilitator Superfamily
HBL79_RS08020	COG0557	exoribonuclease II activity
HBL79_RS08040	COG0681	Belongs to the peptidase S26 family
HBL79_RS08080	COG0105	UTP biosynthetic process
HBL79_RS08100	COG2198	Histidine kinase
HBL79_RS08100	COG0784	Response regulator, receiver
HBL79_RS08100	COG5002	protein histidine kinase activity
HBL79_RS08105	COG0385	Bile acid
HBL79_RS08110	COG2814	Major facilitator Superfamily
HBL79_RS08115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HBL79_RS08125	COG2252	PERMEase
HBL79_RS08130	COG1555	photosystem II stabilization
HBL79_RS08135	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HBL79_RS08140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HBL79_RS08150	COG1238	metal cluster binding
HBL79_RS08155	COG0110	maltose O-acetyltransferase activity
HBL79_RS08185	COG1238	metal cluster binding
HBL79_RS08205	COG4783	chaperone-mediated protein folding
HBL79_RS08215	COG0814	amino acid
HBL79_RS08220	COG2226	methyltransferase
HBL79_RS08225	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HBL79_RS08230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HBL79_RS08245	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HBL79_RS08245	COG0131	Imidazoleglycerol-phosphate dehydratase
HBL79_RS08250	COG4804	nuclease activity
HBL79_RS08260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HBL79_RS08270	COG0107	imidazoleglycerol-phosphate synthase activity
HBL79_RS08285	COG3161	chorismate lyase activity
HBL79_RS08290	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HBL79_RS08295	COG2233	PERMEase
HBL79_RS08300	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HBL79_RS08305	COG0066	3-isopropylmalate dehydratase activity
HBL79_RS08310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HBL79_RS08325	COG4133	protoheme IX ABC transporter activity
HBL79_RS08330	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HBL79_RS08335	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HBL79_RS08340	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HBL79_RS08350	COG1138	Cytochrome C-type biogenesis protein
HBL79_RS08355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HBL79_RS08370	COG4211	Belongs to the binding-protein-dependent transport system permease family
HBL79_RS08375	COG1129	ABC transporter
HBL79_RS08380	COG1879	ABC-type sugar transport system periplasmic component
HBL79_RS08385	COG1085	galactose-1-phosphate uridylyltransferase
HBL79_RS08395	COG2017	converts alpha-aldose to the beta-anomer
HBL79_RS08405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HBL79_RS08410	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HBL79_RS08415	COG1882	Formate acetyltransferase
HBL79_RS08420	COG2116	formate transmembrane transporter activity
HBL79_RS08425	COG0537	adenosine 5'-monophosphoramidase activity
HBL79_RS08440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HBL79_RS08455	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HBL79_RS08460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HBL79_RS08465	COG0254	rRNA binding
HBL79_RS08470	COG1253	flavin adenine dinucleotide binding
HBL79_RS08480	COG0084	hydrolase, TatD family'
HBL79_RS08485	COG0470	DNA polymerase III
HBL79_RS08490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HBL79_RS08495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HBL79_RS08510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HBL79_RS08515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HBL79_RS08525	COG0330	HflC and HflK could
HBL79_RS08530	COG0330	HflC and HflK could
HBL79_RS08545	COG0326	Molecular chaperone. Has ATPase activity
HBL79_RS08550	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HBL79_RS08555	COG3091	SprT-like family
HBL79_RS08560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HBL79_RS08565	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HBL79_RS08600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HBL79_RS08620	COG0210	DNA helicase
HBL79_RS08625	COG5645	(Lipo)protein
HBL79_RS08640	COG1447	Phosphotransferase system cellobiose-specific component IIA
HBL79_RS08645	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HBL79_RS08650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HBL79_RS08655	COG1446	asparaginase
HBL79_RS08660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HBL79_RS08670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HBL79_RS08675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBL79_RS08700	COG2183	response to ionizing radiation
HBL79_RS08705	COG1114	Component of the transport system for branched-chain amino acids
HBL79_RS08710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HBL79_RS08730	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HBL79_RS08735	COG0456	acetyltransferase
HBL79_RS08740	COG1022	Amp-dependent synthetase and ligase
HBL79_RS08745	COG1027	Aspartate ammonia-lyase
HBL79_RS08755	COG0740	serine-type endopeptidase activity
HBL79_RS08780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBL79_RS08785	COG3263	regulation of cellular component size
HBL79_RS08790	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HBL79_RS08790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HBL79_RS08800	COG3722	fumarate hydratase activity
HBL79_RS08805	COG0246	Mannitol dehydrogenase
HBL79_RS08820	COG0848	biopolymer transport protein
HBL79_RS08825	COG0811	peptide transport
HBL79_RS08830	COG4536	flavin adenine dinucleotide binding
HBL79_RS08835	COG4137	Cytochrome C assembly protein
HBL79_RS08840	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HBL79_RS08850	COG3036	rescue of stalled ribosome
HBL79_RS08855	COG1393	Belongs to the ArsC family
HBL79_RS08865	COG1126	abc transporter atp-binding protein
HBL79_RS08870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBL79_RS08875	COG4215	(ABC) transporter
HBL79_RS08880	COG4160	amino acid transport
HBL79_RS08905	COG0174	glutamine synthetase
HBL79_RS08925	COG3306	glycosyltransferase involved in LPS biosynthesis
HBL79_RS08940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HBL79_RS08960	COG0312	modulator of DNA gyrase
HBL79_RS08965	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HBL79_RS08975	COG1271	oxidase subunit
HBL79_RS08980	COG1294	oxidase, subunit
HBL79_RS08990	COG3790	cyd operon protein YbgE
HBL79_RS09000	COG0824	Thioesterase
HBL79_RS09005	COG0811	peptide transport
HBL79_RS09010	COG0848	biopolymer transport protein
HBL79_RS09015	COG3064	Membrane
HBL79_RS09040	COG2165	general secretion pathway protein
HBL79_RS09045	COG4795	General secretion pathway protein
HBL79_RS09060	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HBL79_RS09065	COG0561	phosphatase activity
HBL79_RS09070	COG0235	Class ii aldolase
HBL79_RS09075	COG3623	hexulose-6-phosphate isomerase
HBL79_RS09100	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HBL79_RS09170	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HBL79_RS09175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HBL79_RS09180	COG1739	Uncharacterized protein family UPF0029
HBL79_RS09185	COG0425	Belongs to the sulfur carrier protein TusA family
HBL79_RS09195	COG4942	peptidase
HBL79_RS09200	COG2861	carbohydrate metabolic process
HBL79_RS09205	COG1040	competence protein
HBL79_RS09215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HBL79_RS09230	COG3850	Histidine kinase
HBL79_RS09235	COG3062	negative regulation of establishment of protein localization
HBL79_RS09240	COG0243	molybdopterin cofactor binding
HBL79_RS09245	COG0437	4 iron, 4 sulfur cluster binding
HBL79_RS09250	COG0348	domain, Protein
HBL79_RS09255	COG3043	anaerobic respiration
HBL79_RS09260	COG3005	denitrification pathway
HBL79_RS09270	COG4785	May be involved in cell division
HBL79_RS09275	COG0513	Belongs to the DEAD box helicase family
HBL79_RS09290	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HBL79_RS09295	COG0569	domain protein
HBL79_RS09300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HBL79_RS09300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HBL79_RS09315	COG1252	NADH dehydrogenase
HBL79_RS09320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HBL79_RS09330	COG0191	fructose-bisphosphate aldolase activity
HBL79_RS09335	COG0126	phosphoglycerate kinase activity
HBL79_RS09340	COG3719	Belongs to the RNase T2 family
HBL79_RS09345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HBL79_RS09350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HBL79_RS09355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HBL79_RS09365	COG0778	Nitroreductase
HBL79_RS09370	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HBL79_RS09375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HBL79_RS09390	COG1045	serine acetyltransferase
HBL79_RS09395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HBL79_RS09400	COG2194	sulfuric ester hydrolase activity
HBL79_RS09405	COG0789	Transcriptional regulator
HBL79_RS09410	COG2814	Major facilitator Superfamily
HBL79_RS09415	COG1187	pseudouridine synthase activity
HBL79_RS09430	COG1368	sulfuric ester hydrolase activity
HBL79_RS09435	COG0335	large ribosomal subunit rRNA binding
HBL79_RS09445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HBL79_RS09450	COG0228	four-way junction DNA binding
HBL79_RS09455	COG0859	PFAM glycosyl transferase family 9
HBL79_RS09460	COG0463	Glycosyl transferase, family 2
HBL79_RS09465	COG0561	phosphatase activity
HBL79_RS09470	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HBL79_RS09470	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HBL79_RS09475	COG3715	PTS system
HBL79_RS09480	COG3716	PTS system mannose fructose sorbose family IID component
HBL79_RS09495	COG0633	Ferredoxin
HBL79_RS09500	COG0443	Heat shock 70 kDa protein
HBL79_RS09510	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HBL79_RS09520	COG0822	iron-sulfur transferase activity
HBL79_RS09530	COG1959	2 iron, 2 sulfur cluster binding
HBL79_RS09535	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HBL79_RS09550	COG2837	iron assimilation
HBL79_RS09560	COG0513	Belongs to the DEAD box helicase family
HBL79_RS09565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HBL79_RS09575	COG2853	Lipoprotein
HBL79_RS09600	COG0004	ammonium transporteR
HBL79_RS09600	COG0004	ammonium transporteR
HBL79_RS09605	COG3676	manually curated
HBL79_RS09610	COG2990	Protein conserved in bacteria
HBL79_RS09615	COG0433	COG0433 Predicted ATPase
HBL79_RS09650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HBL79_RS09655	COG0668	transmembrane transport
HBL79_RS09660	COG0248	Ppx GppA phosphatase
HBL79_RS09665	COG2911	Protein conserved in bacteria
HBL79_RS09670	COG0729	surface antigen
HBL79_RS09680	COG0268	Binds directly to 16S ribosomal RNA
HBL79_RS09690	COG0560	Phosphoserine phosphatase
HBL79_RS09705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HBL79_RS09710	COG3085	chromosome segregation
HBL79_RS09715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBL79_RS09720	COG3084	Protein conserved in bacteria
HBL79_RS09730	COG0354	folic acid binding
HBL79_RS09735	COG1561	YicC-like family, N-terminal region
HBL79_RS09740	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HBL79_RS09745	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HBL79_RS09750	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HBL79_RS09760	COG0402	S-adenosylhomocysteine deaminase activity
HBL79_RS09765	COG3083	sulfuric ester hydrolase activity
HBL79_RS09780	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HBL79_RS09785	COG0745	RESPONSE REGULATOR receiver
HBL79_RS09790	COG1584	GPR1 FUN34 yaaH family protein
HBL79_RS09795	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HBL79_RS09800	COG0085	RNA polymerase activity
HBL79_RS09815	COG0081	regulation of translation
HBL79_RS09820	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HBL79_RS09845	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HBL79_RS09850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HBL79_RS09880	COG2923	Belongs to the DsrF TusC family
HBL79_RS09890	COG2964	Protein conserved in bacteria
HBL79_RS09895	COG0545	Peptidyl-prolyl cis-trans isomerase
HBL79_RS09905	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HBL79_RS09905	COG0678	peroxiredoxin activity
HBL79_RS09910	COG0583	DNA-binding transcription factor activity
HBL79_RS09915	COG1309	transcriptional regulator
HBL79_RS09920	COG2267	carboxylic ester hydrolase activity
HBL79_RS09925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HBL79_RS09930	COG0561	phosphatase activity
HBL79_RS09940	COG3978	acetolactate synthase activity
HBL79_RS09980	COG1522	sequence-specific DNA binding
HBL79_RS09990	COG3021	interspecies interaction between organisms
HBL79_RS10000	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HBL79_RS10005	COG2818	Glycosylase
HBL79_RS10010	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HBL79_RS10015	COG3477	response to acidic pH
HBL79_RS10030	COG0538	isocitrate dehydrogenase activity
HBL79_RS10050	COG4145	pantothenate transmembrane transporter activity
HBL79_RS10055	COG3924	membrane
HBL79_RS10060	COG0439	Biotin carboxylase
HBL79_RS10065	COG0511	ligase activity, forming carbon-carbon bonds
HBL79_RS10085	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HBL79_RS10095	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HBL79_RS10105	COG1530	ribonuclease E activity
HBL79_RS10115	COG3276	selenocysteine insertion sequence binding
HBL79_RS10120	COG1921	L-seryl-tRNASec selenium transferase activity
HBL79_RS10125	COG3171	Protein conserved in bacteria
HBL79_RS10130	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HBL79_RS10135	COG0606	chelatase, subunit chli
HBL79_RS10140	COG0076	glutamate decarboxylase activity
HBL79_RS10145	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HBL79_RS10150	COG3787	Belongs to the UPF0306 family
HBL79_RS10155	COG3071	HemY protein
HBL79_RS10160	COG2959	enzyme of heme biosynthesis
HBL79_RS10170	COG0181	hydroxymethylbilane synthase activity
HBL79_RS10180	COG2197	response regulator
HBL79_RS10190	COG1295	ribonuclease BN
HBL79_RS10200	COG1414	Transcriptional regulator
HBL79_RS10205	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HBL79_RS10210	COG2731	YhcH YjgK YiaL family protein
HBL79_RS10215	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HBL79_RS10220	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HBL79_RS10225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HBL79_RS10235	COG3623	hexulose-6-phosphate isomerase
HBL79_RS10240	COG0235	Class ii aldolase
HBL79_RS10250	COG2884	Cell division ATP-binding protein ftsE
HBL79_RS10255	COG2177	Part of the ABC transporter FtsEX involved in
HBL79_RS10265	COG0762	integral membrane protein
HBL79_RS10270	COG0598	Magnesium transport protein CorA
HBL79_RS10280	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HBL79_RS10305	COG3621	Patatin-like phospholipase
HBL79_RS10325	COG4453	Protein conserved in bacteria
HBL79_RS10580	COG0640	Transcriptional regulator
HBL79_RS10595	COG0786	glutamate:sodium symporter activity
HBL79_RS10610	COG3039	Transposase
HBL79_RS10625	COG3039	Transposase
HBL79_RS10670	COG0305	Participates in initiation and elongation during chromosome replication
HBL79_RS10700	COG1194	a g-specific adenine glycosylase
HBL79_RS10705	COG4213	ABC transporter substrate-binding protein
HBL79_RS10710	COG1129	ABC transporter
HBL79_RS10715	COG4214	carbohydrate transport
HBL79_RS10730	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HBL79_RS10745	COG3732	PTS system glucitol sorbitol-specific
HBL79_RS10755	COG1028	Short-chain dehydrogenase reductase Sdr
HBL79_RS10760	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HBL79_RS10765	COG1349	DNA-binding transcription factor activity
HBL79_RS10780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HBL79_RS10785	COG1757	Na H antiporter
HBL79_RS10790	COG0436	Aminotransferase
HBL79_RS10795	COG2115	Belongs to the xylose isomerase family
HBL79_RS10800	COG1070	Carbohydrate kinase
HBL79_RS10805	COG2207	Transcriptional regulator
HBL79_RS10805	COG1609	Transcriptional regulator
HBL79_RS10845	COG3070	regulator of competence-specific genes
HBL79_RS10865	COG0551	DNA topoisomerase type I activity
HBL79_RS10880	COG0733	neurotransmitter:sodium symporter activity
HBL79_RS10890	COG1858	cytochrome C peroxidase
HBL79_RS10895	COG1132	(ABC) transporter
HBL79_RS10900	COG4988	ABC transporter
HBL79_RS10910	COG0187	DNA topoisomerase II activity
HBL79_RS10915	COG1494	fructose-1,6-bisphosphatase
HBL79_RS10925	COG0716	FMN binding
HBL79_RS10935	COG0357	Ribosomal RNA small subunit methyltransferase G
HBL79_RS10960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HBL79_RS10970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HBL79_RS10975	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HBL79_RS10985	COG0483	inositol monophosphate 1-phosphatase activity
HBL79_RS10990	COG2271	Major facilitator Superfamily
HBL79_RS11025	COG1230	cation diffusion facilitator family transporter
HBL79_RS11040	COG3153	acetyltransferase
HBL79_RS11060	COG2195	Cleaves the N-terminal amino acid of tripeptides
HBL79_RS11095	COG0019	diaminopimelate decarboxylase activity
HBL79_RS11130	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HBL79_RS11140	COG3119	arylsulfatase activity
HBL79_RS11150	COG0583	DNA-binding transcription factor activity
HBL79_RS11160	COG3956	TIGRFAM MazG family protein
HBL79_RS11175	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HBL79_RS11185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HBL79_RS11190	COG1114	Component of the transport system for branched-chain amino acids
HBL79_RS11195	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HBL79_RS11200	COG2095	MarC family integral membrane protein
HBL79_RS11215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HBL79_RS11275	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HBL79_RS11295	COG0201	protein transport
HBL79_RS11305	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HBL79_RS11310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HBL79_RS11315	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HBL79_RS11320	COG0202	RNA polymerase activity
HBL79_RS11325	COG0203	ribosomal protein L17
HBL79_RS11335	COG2960	long-chain fatty acid transporting porin activity
HBL79_RS11340	COG3172	ATPase kinase involved in NAD metabolism
HBL79_RS11345	COG2129	metallophosphoesterase
HBL79_RS11355	COG0582	viral genome integration into host DNA
HBL79_RS11450	COG0732	type I restriction modification DNA specificity domain
HBL79_RS11455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HBL79_RS11460	COG3056	Lipoprotein
HBL79_RS11465	COG0271	Belongs to the BolA IbaG family
HBL79_RS11480	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HBL79_RS11485	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HBL79_RS11490	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HBL79_RS11500	COG1477	protein flavinylation
HBL79_RS11505	COG2991	Protein conserved in bacteria
HBL79_RS11515	COG1519	Transferase
HBL79_RS11525	COG0786	glutamate:sodium symporter activity
HBL79_RS11555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HBL79_RS11565	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HBL79_RS11570	COG3068	Protein conserved in bacteria
HBL79_RS11580	COG1349	DNA-binding transcription factor activity
HBL79_RS11585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HBL79_RS11595	COG0259	pyridoxamine-phosphate oxidase activity
HBL79_RS11600	COG2814	Major facilitator Superfamily
HBL79_RS11605	COG1763	Mo-molybdopterin cofactor biosynthetic process
HBL79_RS11610	COG3086	response to oxidative stress
HBL79_RS11615	COG3026	antisigma factor binding
HBL79_RS11620	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HBL79_RS11625	COG1595	DNA-templated transcription, initiation
HBL79_RS11640	COG2226	methyltransferase
HBL79_RS11670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HBL79_RS11675	COG0493	'glutamate synthase
HBL79_RS11680	COG0067	glutamate synthase
HBL79_RS11680	COG0070	glutamate synthase
HBL79_RS11680	COG0069	glutamate synthase activity
HBL79_RS11690	COG0859	PFAM glycosyl transferase family 9
HBL79_RS11695	COG1132	(ABC) transporter
HBL79_RS11705	COG0549	Belongs to the carbamate kinase family
HBL79_RS11715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HBL79_RS11725	COG1304	FMN binding
HBL79_RS11730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HBL79_RS11740	COG0583	DNA-binding transcription factor activity
HBL79_RS11750	COG1304	FMN binding
HBL79_RS11755	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HBL79_RS11760	COG0666	response to abiotic stimulus
HBL79_RS11785	COG0675	Transposase, IS605 OrfB family
HBL79_RS11795	COG1126	abc transporter atp-binding protein
HBL79_RS11800	COG0765	amino acid transport
HBL79_RS11805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBL79_RS11810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HBL79_RS11820	COG3078	GTPase activator activity
HBL79_RS11825	COG0564	pseudouridine synthase activity
HBL79_RS11840	COG0673	inositol 2-dehydrogenase activity
HBL79_RS11845	COG3676	manually curated
HBL79_RS11855	COG3718	enzyme involved in inositol metabolism
HBL79_RS11870	COG0456	acetyltransferase
HBL79_RS11900	COG0738	Major facilitator superfamily
HBL79_RS11905	COG0235	Class ii aldolase
HBL79_RS11920	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
HBL79_RS11925	COG1349	DNA-binding transcription factor activity
HBL79_RS11935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HBL79_RS11950	COG0859	PFAM glycosyl transferase family 9
HBL79_RS11990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HBL79_RS12005	COG3691	Protein conserved in bacteria
HBL79_RS12010	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HBL79_RS12015	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HBL79_RS12020	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HBL79_RS12025	COG0363	glucosamine-6-phosphate deaminase activity
HBL79_RS12030	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HBL79_RS12035	COG1218	3'(2'),5'-bisphosphate nucleotidase
HBL79_RS12040	COG1297	OPT oligopeptide transporter protein
HBL79_RS12045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HBL79_RS12050	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HBL79_RS12055	COG1609	Transcriptional regulator
HBL79_RS12060	COG1917	Cupin 2, conserved barrel domain protein
HBL79_RS12070	COG1070	Carbohydrate kinase
HBL79_RS12075	COG1129	ABC transporter
HBL79_RS12080	COG1172	Belongs to the binding-protein-dependent transport system permease family
HBL79_RS12085	COG1879	ABC-type sugar transport system periplasmic component
HBL79_RS12100	COG0051	transcription antitermination factor activity, RNA binding
HBL79_RS12110	COG0088	Forms part of the polypeptide exit tunnel
HBL79_RS12120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HBL79_RS12125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HBL79_RS12135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HBL79_RS12160	COG0582	viral genome integration into host DNA
HBL79_RS12245	COG3728	DNA packaging