locus-tag	class	description
L4F93_RS00010	COG1914	H( )-stimulated, divalent metal cation uptake system
L4F93_RS00015	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
L4F93_RS00020	COG1984	allophanate hydrolase subunit 2
L4F93_RS00025	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L4F93_RS00045	COG0471	metal ion transport
L4F93_RS00055	COG1643	Atp-dependent helicase
L4F93_RS00060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L4F93_RS00065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L4F93_RS00075	COG0484	heat shock protein binding
L4F93_RS00080	COG0443	Heat shock 70 kDa protein
L4F93_RS00085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L4F93_RS00095	COG0739	heme binding
L4F93_RS00100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
L4F93_RS00115	COG2217	Heavy metal translocating P-type atpase
L4F93_RS00135	COG0437	4 iron, 4 sulfur cluster binding
L4F93_RS00140	COG2864	formate dehydrogenase
L4F93_RS00155	COG2850	peptidyl-arginine hydroxylation
L4F93_RS00165	COG2867	negative regulation of translational initiation
L4F93_RS00180	COG0012	GTP binding
L4F93_RS00190	COG0531	amino acid
L4F93_RS00205	COG3106	COG3106 Predicted ATPase
L4F93_RS00210	COG4166	transmembrane transport
L4F93_RS00215	COG4168	peptide transport system, permease
L4F93_RS00220	COG4171	peptide transport system, permease
L4F93_RS00225	COG4172	Belongs to the ABC transporter superfamily
L4F93_RS00230	COG4172	Belongs to the ABC transporter superfamily
L4F93_RS00235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L4F93_RS00245	COG0151	Belongs to the GarS family
L4F93_RS00255	COG2259	Doxx family
L4F93_RS00265	COG1368	sulfuric ester hydrolase activity
L4F93_RS00275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L4F93_RS00280	COG1879	ABC-type sugar transport system periplasmic component
L4F93_RS00285	COG1172	Belongs to the binding-protein-dependent transport system permease family
L4F93_RS00300	COG1957	nucleoside hydrolase
L4F93_RS00325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L4F93_RS00335	COG2244	polysaccharide biosynthetic process
L4F93_RS00350	COG2826	transposase and inactivated derivatives, IS30 family
L4F93_RS00360	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
L4F93_RS00365	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
L4F93_RS00395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L4F93_RS00400	COG1621	beta-fructofuranosidase activity
L4F93_RS00405	COG0802	atpase or kinase
L4F93_RS00410	COG0860	N-Acetylmuramoyl-L-alanine amidase
L4F93_RS00410	COG1388	LysM domain
L4F93_RS00415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L4F93_RS00425	COG1923	regulation of RNA biosynthetic process
L4F93_RS00430	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L4F93_RS00435	COG3283	Transcriptional regulator of aromatic amino acids metabolism
L4F93_RS00440	COG1120	ATPase activity
L4F93_RS00455	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
L4F93_RS00460	COG4774	siderophore transport
L4F93_RS00470	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
L4F93_RS00475	COG2824	Alkylphosphonate utilization operon protein PhnA
L4F93_RS00560	COG3210	domain, Protein
L4F93_RS00565	COG2831	hemolysin activation secretion protein
L4F93_RS00570	COG2271	Major facilitator Superfamily
L4F93_RS00575	COG2197	response regulator
L4F93_RS00580	COG3851	Histidine kinase
L4F93_RS00585	COG2271	Major facilitator Superfamily
L4F93_RS00590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L4F93_RS00595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L4F93_RS00600	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L4F93_RS00605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L4F93_RS00625	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L4F93_RS00630	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
L4F93_RS00640	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L4F93_RS00645	COG1053	succinate dehydrogenase
L4F93_RS00650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L4F93_RS00670	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
L4F93_RS00675	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L4F93_RS00680	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
L4F93_RS00690	COG1278	Cold shock
L4F93_RS00695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L4F93_RS00705	COG0737	Belongs to the 5'-nucleotidase family
L4F93_RS00710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L4F93_RS00715	COG5007	Belongs to the BolA IbaG family
L4F93_RS00725	COG2854	intermembrane phospholipid transfer
L4F93_RS00730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L4F93_RS00735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L4F93_RS00740	COG1127	ABC transporter
L4F93_RS00745	COG3117	lipopolysaccharide transmembrane transporter activity
L4F93_RS00750	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L4F93_RS00755	COG1137	ATPase activity
L4F93_RS00760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L4F93_RS00770	COG1312	Catalyzes the dehydration of D-mannonate
L4F93_RS00775	COG2186	Transcriptional regulator
L4F93_RS00790	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
L4F93_RS00800	COG1028	Short-chain dehydrogenase reductase Sdr
L4F93_RS00815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L4F93_RS00830	COG2926	Belongs to the UPF0265 family
L4F93_RS00840	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L4F93_RS00845	COG0142	geranyltranstransferase activity
L4F93_RS00860	COG0697	spore germination
L4F93_RS00865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L4F93_RS00875	COG2860	membrane
L4F93_RS00885	COG0527	aspartate kinase activity
L4F93_RS00890	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L4F93_RS00895	COG0732	type I restriction modification DNA specificity domain
L4F93_RS00905	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L4F93_RS00910	COG2897	thiosulfate sulfurtransferase activity
L4F93_RS00915	COG2391	methyltransferase activity
L4F93_RS00920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L4F93_RS00930	COG3684	Belongs to the aldolase LacD family
L4F93_RS00935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L4F93_RS00940	COG1349	DNA-binding transcription factor activity
L4F93_RS00950	COG3119	arylsulfatase activity
L4F93_RS00955	COG0641	radical SAM
L4F93_RS00965	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
L4F93_RS00970	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
L4F93_RS00975	COG3716	PTS system mannose fructose sorbose family IID component
L4F93_RS00980	COG3715	PTS system
L4F93_RS00985	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L4F93_RS00990	COG2222	sugar isomerase
L4F93_RS01000	COG3119	arylsulfatase activity
L4F93_RS01010	COG1414	Transcriptional regulator
L4F93_RS01015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L4F93_RS01020	COG0800	Aldolase
L4F93_RS01050	COG0584	glycerophosphoryl diester phosphodiesterase
L4F93_RS01055	COG3842	ATPase activity
L4F93_RS01060	COG1175	transmembrane transport
L4F93_RS01065	COG1177	transmembrane transport
L4F93_RS01090	COG1509	lysine 2,3-aminomutase activity
L4F93_RS01095	COG3266	domain, Protein
L4F93_RS01095	COG3061	Opacity-associated protein A
L4F93_RS01100	COG2974	May be involved in recombination
L4F93_RS01110	COG2814	Major facilitator Superfamily
L4F93_RS01115	COG4974	Belongs to the 'phage' integrase family
L4F93_RS01150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L4F93_RS01180	COG0602	queuosine metabolic process
L4F93_RS01185	COG0720	synthase
L4F93_RS01190	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L4F93_RS01195	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L4F93_RS01200	COG1115	amino acid carrier protein
L4F93_RS01215	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L4F93_RS01215	COG0237	dephospho-CoA kinase activity
L4F93_RS01225	COG1459	type II secretion system
L4F93_RS01230	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
L4F93_RS01230	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L4F93_RS01235	COG3715	PTS system
L4F93_RS01240	COG3716	PTS system mannose fructose sorbose family IID component
L4F93_RS01290	COG1368	sulfuric ester hydrolase activity
L4F93_RS01300	COG0681	Belongs to the peptidase S26 family
L4F93_RS01315	COG2976	Protein conserved in bacteria
L4F93_RS01330	COG1426	Protein conserved in bacteria
L4F93_RS01335	COG3063	Type IV pilus biogenesis stability protein PilW
L4F93_RS01350	COG0628	permease
L4F93_RS01360	COG0521	Mo-molybdopterin cofactor biosynthetic process
L4F93_RS01365	COG4589	Belongs to the CDS family
L4F93_RS01375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L4F93_RS01380	COG0490	domain, Protein
L4F93_RS01380	COG0471	metal ion transport
L4F93_RS01385	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L4F93_RS01400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L4F93_RS01405	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L4F93_RS01420	COG0750	zinc metalloprotease
L4F93_RS01425	COG0575	Belongs to the CDS family
L4F93_RS01435	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L4F93_RS01450	COG2194	sulfuric ester hydrolase activity
L4F93_RS01460	COG0204	Acyl-transferase
L4F93_RS01470	COG0121	glutamine amidotransferase
L4F93_RS01475	COG0814	amino acid
L4F93_RS01480	COG1760	l-serine dehydratase
L4F93_RS01490	COG2081	HI0933 family
L4F93_RS01495	COG4235	cytochrome complex assembly
L4F93_RS01495	COG3088	subunit of a heme lyase
L4F93_RS01500	COG4235	cytochrome complex assembly
L4F93_RS01500	COG3088	subunit of a heme lyase
L4F93_RS01510	COG1138	Cytochrome C-type biogenesis protein
L4F93_RS01515	COG3301	Polysulphide reductase, NrfD
L4F93_RS01520	COG0437	4 iron, 4 sulfur cluster binding
L4F93_RS01525	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
L4F93_RS01530	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
L4F93_RS01540	COG0799	negative regulation of ribosome biogenesis
L4F93_RS01550	COG0768	penicillin binding
L4F93_RS01555	COG0772	Belongs to the SEDS family
L4F93_RS01565	COG1686	Belongs to the peptidase S11 family
L4F93_RS01575	COG0321	lipoyl(octanoyl) transferase activity
L4F93_RS01585	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L4F93_RS01605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L4F93_RS01610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L4F93_RS01615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L4F93_RS01620	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L4F93_RS01630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L4F93_RS01635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L4F93_RS01640	COG2194	sulfuric ester hydrolase activity
L4F93_RS01645	COG0789	Transcriptional regulator
L4F93_RS01650	COG2814	Major facilitator Superfamily
L4F93_RS01655	COG1187	pseudouridine synthase activity
L4F93_RS01660	COG0281	malic enzyme
L4F93_RS01660	COG0280	phosphate acetyltransferase
L4F93_RS01675	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
L4F93_RS01680	COG1959	2 iron, 2 sulfur cluster binding
L4F93_RS01690	COG0822	iron-sulfur transferase activity
L4F93_RS01700	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
L4F93_RS01705	COG0443	Heat shock 70 kDa protein
L4F93_RS01710	COG0633	Ferredoxin
L4F93_RS01725	COG3716	PTS system mannose fructose sorbose family IID component
L4F93_RS01730	COG3715	PTS system
L4F93_RS01735	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L4F93_RS01735	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
L4F93_RS01740	COG0561	phosphatase activity
L4F93_RS01745	COG1027	Aspartate ammonia-lyase
L4F93_RS01755	COG1530	ribonuclease E activity
L4F93_RS01770	COG0740	serine-type endopeptidase activity
L4F93_RS01780	COG1652	LysM domain
L4F93_RS01785	COG2321	neutral zinc metallopeptidase
L4F93_RS01790	COG1741	Belongs to the pirin family
L4F93_RS01800	COG1454	alcohol dehydrogenase
L4F93_RS01800	COG1012	belongs to the aldehyde dehydrogenase family
L4F93_RS01805	COG0783	Belongs to the Dps family
L4F93_RS01810	COG0512	Glutamine amidotransferase of anthranilate synthase
L4F93_RS01820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L4F93_RS01825	COG0251	oxidation-reduction process
L4F93_RS01835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L4F93_RS01855	COG3468	outer membrane autotransporter barrel domain protein
L4F93_RS01865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L4F93_RS01870	COG1720	tRNA m6t6A37 methyltransferase activity
L4F93_RS01875	COG1575	Belongs to the MenA family. Type 1 subfamily
L4F93_RS01885	COG0471	metal ion transport
L4F93_RS01900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L4F93_RS01915	COG0805	protein transport
L4F93_RS01925	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
L4F93_RS01950	COG3623	hexulose-6-phosphate isomerase
L4F93_RS01955	COG0235	Class ii aldolase
L4F93_RS01960	COG0561	phosphatase activity
L4F93_RS01965	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L4F93_RS01980	COG4795	General secretion pathway protein
L4F93_RS01985	COG2165	general secretion pathway protein
L4F93_RS02015	COG3064	Membrane
L4F93_RS02020	COG0848	biopolymer transport protein
L4F93_RS02025	COG0811	peptide transport
L4F93_RS02030	COG0824	Thioesterase
L4F93_RS02045	COG1294	oxidase, subunit
L4F93_RS02050	COG1271	oxidase subunit
L4F93_RS02060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L4F93_RS02065	COG0312	modulator of DNA gyrase
L4F93_RS02070	COG3028	Belongs to the UPF0307 family
L4F93_RS02075	COG0330	HflC and HflK could
L4F93_RS02080	COG0330	HflC and HflK could
L4F93_RS02095	COG0326	Molecular chaperone. Has ATPase activity
L4F93_RS02100	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L4F93_RS02110	COG1028	Short-chain dehydrogenase reductase Sdr
L4F93_RS02115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L4F93_RS02120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L4F93_RS02125	COG0416	fatty acid biosynthetic process
L4F93_RS02135	COG1399	metal-binding, possibly nucleic acid-binding protein
L4F93_RS02140	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
L4F93_RS02145	COG0500	methyltransferase
L4F93_RS02150	COG2830	Protein of unknown function (DUF452)
L4F93_RS02160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L4F93_RS02165	COG0688	phosphatidylethanolamine metabolic process
L4F93_RS02170	COG0545	Peptidyl-prolyl cis-trans isomerase
L4F93_RS02185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
L4F93_RS02190	COG4972	Pilus assembly protein
L4F93_RS02210	COG4796	Type ii and iii secretion system protein
L4F93_RS02220	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L4F93_RS02225	COG0338	D12 class N6 adenine-specific DNA methyltransferase
L4F93_RS02230	COG4701	Protein of unknown function (DUF721)
L4F93_RS02245	COG0494	nUDIX hydrolase
L4F93_RS02260	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L4F93_RS02280	COG2026	Addiction module toxin, RelE StbE family
L4F93_RS02285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L4F93_RS02300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L4F93_RS02325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L4F93_RS02330	COG1114	Component of the transport system for branched-chain amino acids
L4F93_RS02335	COG2183	response to ionizing radiation
L4F93_RS02360	COG3716	PTS system mannose fructose sorbose family IID component
L4F93_RS02365	COG3715	PTS system
L4F93_RS02370	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L4F93_RS02390	COG0196	riboflavin kinase activity
L4F93_RS02405	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L4F93_RS02410	COG0594	ribonuclease P activity
L4F93_RS02420	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L4F93_RS02425	COG0592	DNA-directed DNA polymerase activity
L4F93_RS02435	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
L4F93_RS02445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L4F93_RS02450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L4F93_RS02490	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
L4F93_RS02495	COG1970	mechanosensitive ion channel activity
L4F93_RS02500	COG0569	domain protein
L4F93_RS02535	COG4145	pantothenate transmembrane transporter activity
L4F93_RS02540	COG3924	membrane
L4F93_RS02545	COG0439	Biotin carboxylase
L4F93_RS02550	COG0511	ligase activity, forming carbon-carbon bonds
L4F93_RS02570	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L4F93_RS02580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L4F93_RS02590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L4F93_RS02610	COG0006	proline dipeptidase activity
L4F93_RS02615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L4F93_RS02620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L4F93_RS02625	COG0753	catalase activity
L4F93_RS02630	COG3718	enzyme involved in inositol metabolism
L4F93_RS02640	COG0673	inositol 2-dehydrogenase activity
L4F93_RS02645	COG3201	nicotinamide mononucleotide transporter
L4F93_RS02655	COG0564	pseudouridine synthase activity
L4F93_RS02660	COG3078	GTPase activator activity
L4F93_RS02670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L4F93_RS02675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L4F93_RS02680	COG0765	amino acid transport
L4F93_RS02685	COG1126	abc transporter atp-binding protein
L4F93_RS02690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L4F93_RS02690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L4F93_RS02700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L4F93_RS02710	COG0335	large ribosomal subunit rRNA binding
L4F93_RS02720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L4F93_RS02725	COG0228	four-way junction DNA binding
L4F93_RS02730	COG0438	transferase activity, transferring glycosyl groups
L4F93_RS02735	COG0463	Glycosyl transferase, family 2
L4F93_RS02740	COG2364	Membrane
L4F93_RS02745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L4F93_RS02750	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
L4F93_RS02760	COG0038	chloride channel
L4F93_RS02775	COG0431	NADPH-dependent FMN reductase
L4F93_RS02785	COG1172	Belongs to the binding-protein-dependent transport system permease family
L4F93_RS02790	COG1129	ABC transporter
L4F93_RS02800	COG1879	ABC-type sugar transport system periplasmic component
L4F93_RS02805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L4F93_RS02810	COG1028	Short-chain dehydrogenase reductase Sdr
L4F93_RS02875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L4F93_RS02880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L4F93_RS02935	COG1131	(ABC) transporter
L4F93_RS02960	COG2814	Major facilitator Superfamily
L4F93_RS02965	COG1763	Mo-molybdopterin cofactor biosynthetic process
L4F93_RS02970	COG2271	Major facilitator Superfamily
L4F93_RS02975	COG3086	response to oxidative stress
L4F93_RS02980	COG3026	antisigma factor binding
L4F93_RS02985	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
L4F93_RS02990	COG1595	DNA-templated transcription, initiation
L4F93_RS03000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L4F93_RS03000	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L4F93_RS03000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L4F93_RS03005	COG1105	Belongs to the carbohydrate kinase PfkB family
L4F93_RS03010	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L4F93_RS03010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L4F93_RS03025	COG3084	Protein conserved in bacteria
L4F93_RS03030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L4F93_RS03035	COG3085	chromosome segregation
L4F93_RS03065	COG1476	TRANSCRIPTIONal
L4F93_RS03075	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L4F93_RS03085	COG0076	glutamate decarboxylase activity
L4F93_RS03090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L4F93_RS03100	COG3071	HemY protein
L4F93_RS03105	COG2959	enzyme of heme biosynthesis
L4F93_RS03115	COG0181	hydroxymethylbilane synthase activity
L4F93_RS03125	COG2197	response regulator
L4F93_RS03130	COG2205	protein histidine kinase activity
L4F93_RS03135	COG0745	RESPONSE REGULATOR receiver
L4F93_RS03140	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L4F93_RS03155	COG3083	sulfuric ester hydrolase activity
L4F93_RS03160	COG0402	S-adenosylhomocysteine deaminase activity
L4F93_RS03170	COG2801	Transposase and inactivated derivatives
L4F93_RS03175	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L4F93_RS03180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L4F93_RS03185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L4F93_RS03190	COG1381	Involved in DNA repair and RecF pathway recombination
L4F93_RS03195	COG4214	carbohydrate transport
L4F93_RS03200	COG1129	ABC transporter
L4F93_RS03205	COG4213	ABC transporter substrate-binding protein
L4F93_RS03210	COG1757	Na H antiporter
L4F93_RS03215	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L4F93_RS03220	COG2115	Belongs to the xylose isomerase family
L4F93_RS03225	COG1070	Carbohydrate kinase
L4F93_RS03230	COG1609	Transcriptional regulator
L4F93_RS03230	COG2207	Transcriptional regulator
L4F93_RS03240	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L4F93_RS03260	COG0732	type I restriction modification DNA specificity domain
L4F93_RS03285	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L4F93_RS03300	COG3477	response to acidic pH
L4F93_RS03315	COG0538	isocitrate dehydrogenase activity
L4F93_RS03360	COG0606	chelatase, subunit chli
L4F93_RS03365	COG2129	metallophosphoesterase
L4F93_RS03370	COG3172	ATPase kinase involved in NAD metabolism
L4F93_RS03375	COG2960	long-chain fatty acid transporting porin activity
L4F93_RS03380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L4F93_RS03390	COG0202	RNA polymerase activity
L4F93_RS03400	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L4F93_RS03405	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L4F93_RS03415	COG0201	protein transport
L4F93_RS03435	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L4F93_RS03495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L4F93_RS03510	COG2095	MarC family integral membrane protein
L4F93_RS03515	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L4F93_RS03535	COG3978	acetolactate synthase activity
L4F93_RS03545	COG0561	phosphatase activity
L4F93_RS03550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L4F93_RS03555	COG2267	carboxylic ester hydrolase activity
L4F93_RS03560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L4F93_RS03565	COG2177	Part of the ABC transporter FtsEX involved in
L4F93_RS03570	COG2884	Cell division ATP-binding protein ftsE
L4F93_RS03575	COG2814	Major facilitator Superfamily
L4F93_RS03580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L4F93_RS03585	COG1349	DNA-binding transcription factor activity
L4F93_RS03595	COG3068	Protein conserved in bacteria
L4F93_RS03600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L4F93_RS03610	COG1584	GPR1 FUN34 yaaH family protein
L4F93_RS03615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L4F93_RS03620	COG0085	RNA polymerase activity
L4F93_RS03635	COG0081	regulation of translation
L4F93_RS03640	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L4F93_RS03650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L4F93_RS03655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L4F93_RS03675	COG2168	tRNA wobble position uridine thiolation
L4F93_RS03690	COG2964	Protein conserved in bacteria
L4F93_RS03695	COG0545	Peptidyl-prolyl cis-trans isomerase
L4F93_RS03705	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L4F93_RS03705	COG0678	peroxiredoxin activity
L4F93_RS03710	COG0583	DNA-binding transcription factor activity
L4F93_RS03715	COG1309	transcriptional regulator
L4F93_RS03720	COG0242	peptide deformylase activity
L4F93_RS03730	COG0560	Phosphoserine phosphatase
L4F93_RS03740	COG0268	Binds directly to 16S ribosomal RNA
L4F93_RS03745	COG0728	peptidoglycan biosynthetic process
L4F93_RS03750	COG0729	surface antigen
L4F93_RS03755	COG2911	Protein conserved in bacteria
L4F93_RS03760	COG0248	Ppx GppA phosphatase
L4F93_RS03770	COG0668	transmembrane transport
L4F93_RS03775	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L4F93_RS03790	COG0859	PFAM glycosyl transferase family 9
L4F93_RS03795	COG0859	PFAM glycosyl transferase family 9
L4F93_RS03800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L4F93_RS03810	COG1132	(ABC) transporter
L4F93_RS03815	COG0859	PFAM glycosyl transferase family 9
L4F93_RS03835	COG2610	gluconate transmembrane transporter activity
L4F93_RS03840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L4F93_RS03845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L4F93_RS03850	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
L4F93_RS03855	COG3622	Belongs to the hyi family
L4F93_RS03860	COG0235	Class ii aldolase
L4F93_RS03865	COG3395	kinase activity
L4F93_RS03870	COG2084	Dehydrogenase
L4F93_RS03875	COG1349	DNA-binding transcription factor activity
L4F93_RS03935	COG0583	DNA-binding transcription factor activity
L4F93_RS03945	COG0488	(ABC) transporter
L4F93_RS03950	COG3630	sodium ion export across plasma membrane
L4F93_RS03955	COG5016	pyruvate
L4F93_RS03955	COG0511	ligase activity, forming carbon-carbon bonds
L4F93_RS03990	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L4F93_RS04005	COG0019	diaminopimelate decarboxylase activity
L4F93_RS04050	COG2195	Cleaves the N-terminal amino acid of tripeptides
L4F93_RS04055	COG2271	Major facilitator Superfamily
L4F93_RS04070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L4F93_RS04075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L4F93_RS04085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L4F93_RS04120	COG0716	FMN binding
L4F93_RS04130	COG1494	fructose-1,6-bisphosphatase
L4F93_RS04135	COG0187	DNA topoisomerase II activity
L4F93_RS04145	COG4988	ABC transporter
L4F93_RS04150	COG1132	(ABC) transporter
L4F93_RS04155	COG1858	cytochrome C peroxidase
L4F93_RS04170	COG0733	neurotransmitter:sodium symporter activity
L4F93_RS04185	COG0551	DNA topoisomerase type I activity
L4F93_RS04210	COG0549	Belongs to the carbamate kinase family
L4F93_RS04220	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L4F93_RS04230	COG1304	FMN binding
L4F93_RS04235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L4F93_RS04240	COG1335	isochorismatase
L4F93_RS04245	COG0583	DNA-binding transcription factor activity
L4F93_RS04265	COG2137	regulation of response to DNA damage stimulus
L4F93_RS04280	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L4F93_RS04285	COG3171	Protein conserved in bacteria
L4F93_RS04300	COG3956	TIGRFAM MazG family protein
L4F93_RS04320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L4F93_RS04325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L4F93_RS04330	COG1114	Component of the transport system for branched-chain amino acids
L4F93_RS04335	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L4F93_RS04340	COG0316	Belongs to the HesB IscA family
L4F93_RS04340	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L4F93_RS04345	COG1040	competence protein
L4F93_RS04360	COG2837	iron assimilation
L4F93_RS04375	COG0513	Belongs to the DEAD box helicase family
L4F93_RS04380	COG2391	methyltransferase activity
L4F93_RS04385	COG0425	Belongs to the sulfur carrier protein TusA family
L4F93_RS04390	COG0598	Magnesium transport protein CorA
L4F93_RS04395	COG0762	integral membrane protein
L4F93_RS04410	COG0765	amino acid transport
L4F93_RS04415	COG0765	amino acid transport
L4F93_RS04425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L4F93_RS04435	COG0456	acetyltransferase
L4F93_RS04450	COG3119	arylsulfatase activity
L4F93_RS04455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L4F93_RS04460	COG0737	Belongs to the 5'-nucleotidase family
L4F93_RS04470	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L4F93_RS04480	COG1028	Short-chain dehydrogenase reductase Sdr
L4F93_RS04490	COG2070	2-Nitropropane dioxygenase
L4F93_RS04500	COG3118	belongs to the thioredoxin family
L4F93_RS04505	COG2207	Transcriptional regulator
L4F93_RS04515	COG2070	2-Nitropropane dioxygenase
L4F93_RS04525	COG0583	DNA-binding transcription factor activity
L4F93_RS04530	COG1902	pentaerythritol trinitrate reductase activity
L4F93_RS04585	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L4F93_RS04595	COG3730	PTS system glucitol sorbitol-specific
L4F93_RS04610	COG1028	Short-chain dehydrogenase reductase Sdr
L4F93_RS04615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L4F93_RS04620	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
L4F93_RS04625	COG1349	DNA-binding transcription factor activity
L4F93_RS04640	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L4F93_RS04645	COG1194	a g-specific adenine glycosylase
L4F93_RS04675	COG3056	Lipoprotein
L4F93_RS04680	COG0271	Belongs to the BolA IbaG family
L4F93_RS04695	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L4F93_RS04700	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L4F93_RS04705	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L4F93_RS04710	COG2871	sodium ion transport
L4F93_RS04715	COG1477	protein flavinylation
L4F93_RS04720	COG2991	Protein conserved in bacteria
L4F93_RS04730	COG1519	Transferase
L4F93_RS04750	COG0786	glutamate:sodium symporter activity
L4F93_RS04780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L4F93_RS04800	COG0433	COG0433 Predicted ATPase
L4F93_RS04805	COG2608	mercury ion transmembrane transporter activity
L4F93_RS04820	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
L4F93_RS04825	COG1522	sequence-specific DNA binding
L4F93_RS04840	COG2853	Lipoprotein
L4F93_RS04855	COG0004	ammonium transporteR
L4F93_RS04860	COG1414	Transcriptional regulator
L4F93_RS04865	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
L4F93_RS04870	COG2731	YhcH YjgK YiaL family protein
L4F93_RS04875	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
L4F93_RS04880	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L4F93_RS04885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L4F93_RS04895	COG3623	hexulose-6-phosphate isomerase
L4F93_RS04900	COG0235	Class ii aldolase
L4F93_RS04905	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
L4F93_RS04915	COG3962	Belongs to the TPP enzyme family
L4F93_RS04925	COG0673	inositol 2-dehydrogenase activity
L4F93_RS04930	COG3691	Protein conserved in bacteria
L4F93_RS04935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L4F93_RS04940	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
L4F93_RS04945	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
L4F93_RS04950	COG0363	glucosamine-6-phosphate deaminase activity
L4F93_RS04955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L4F93_RS04960	COG1218	3'(2'),5'-bisphosphate nucleotidase
L4F93_RS04965	COG1297	OPT oligopeptide transporter protein
L4F93_RS04970	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L4F93_RS04975	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L4F93_RS04990	COG0051	transcription antitermination factor activity, RNA binding
L4F93_RS05000	COG0088	Forms part of the polypeptide exit tunnel
L4F93_RS05010	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L4F93_RS05015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L4F93_RS05025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L4F93_RS05040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L4F93_RS05045	COG0252	asparaginase activity
L4F93_RS05050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L4F93_RS05055	COG2818	Glycosylase
L4F93_RS05060	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
L4F93_RS05065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L4F93_RS05070	COG1275	C4-dicarboxylate transporter malic acid transport protein
L4F93_RS05080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L4F93_RS05085	COG3850	Histidine kinase
L4F93_RS05090	COG3062	negative regulation of establishment of protein localization
L4F93_RS05095	COG0243	molybdopterin cofactor binding
L4F93_RS05100	COG0437	4 iron, 4 sulfur cluster binding
L4F93_RS05105	COG0348	domain, Protein
L4F93_RS05110	COG3043	anaerobic respiration
L4F93_RS05115	COG3005	denitrification pathway
L4F93_RS05125	COG4785	May be involved in cell division
L4F93_RS05130	COG0513	Belongs to the DEAD box helicase family
L4F93_RS05135	COG2226	methyltransferase
L4F93_RS05185	COG1496	oxidoreductase activity
L4F93_RS05190	COG0354	folic acid binding
L4F93_RS05195	COG1561	YicC-like family, N-terminal region
L4F93_RS05200	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L4F93_RS05205	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L4F93_RS05210	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
L4F93_RS05215	COG0191	fructose-bisphosphate aldolase activity
L4F93_RS05220	COG0126	phosphoglycerate kinase activity
L4F93_RS05225	COG3719	Belongs to the RNase T2 family
L4F93_RS05230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L4F93_RS05235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L4F93_RS05240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L4F93_RS05250	COG0778	Nitroreductase
L4F93_RS05255	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L4F93_RS05260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L4F93_RS05265	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
L4F93_RS05275	COG1045	serine acetyltransferase
L4F93_RS05280	COG3276	selenocysteine insertion sequence binding
L4F93_RS05285	COG1921	L-seryl-tRNASec selenium transferase activity
L4F93_RS05385	COG2861	carbohydrate metabolic process
L4F93_RS05390	COG4942	peptidase
L4F93_RS05400	COG0425	Belongs to the sulfur carrier protein TusA family
L4F93_RS05405	COG1739	Uncharacterized protein family UPF0029
L4F93_RS05410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L4F93_RS05415	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
L4F93_RS05420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L4F93_RS05460	COG1555	photosystem II stabilization
L4F93_RS05465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L4F93_RS05470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L4F93_RS05480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L4F93_RS05485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L4F93_RS05490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L4F93_RS05495	COG0470	DNA polymerase III
L4F93_RS05500	COG0084	hydrolase, TatD family'
L4F93_RS05510	COG1253	flavin adenine dinucleotide binding
L4F93_RS05515	COG0254	rRNA binding
L4F93_RS05520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L4F93_RS05525	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L4F93_RS05530	COG1309	transcriptional regulator
L4F93_RS05535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L4F93_RS05540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L4F93_RS05545	COG0504	CTP synthase activity
L4F93_RS05555	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
L4F93_RS05560	COG5645	(Lipo)protein
L4F93_RS05565	COG0210	DNA helicase
L4F93_RS05590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L4F93_RS05595	COG0110	maltose O-acetyltransferase activity
L4F93_RS05600	COG1238	metal cluster binding
L4F93_RS05610	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
L4F93_RS05620	COG0705	Rhomboid family
L4F93_RS05625	COG1349	DNA-binding transcription factor activity
L4F93_RS05630	COG0247	lactate metabolic process
L4F93_RS05640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L4F93_RS05645	COG2271	Major facilitator Superfamily
L4F93_RS05650	COG0584	glycerophosphoryl diester phosphodiesterase
L4F93_RS05655	COG0552	protein localization to endoplasmic reticulum
L4F93_RS05660	COG0742	ribosomal rna small subunit methyltransferase
L4F93_RS05665	COG0758	DNA mediated transformation
L4F93_RS05675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L4F93_RS05685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L4F93_RS05685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L4F93_RS05690	COG3722	fumarate hydratase activity
L4F93_RS05695	COG0246	Mannitol dehydrogenase
L4F93_RS05710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L4F93_RS05715	COG1077	Cell shape determining protein MreB Mrl
L4F93_RS05720	COG1792	Involved in formation and maintenance of cell shape
L4F93_RS05725	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L4F93_RS05755	COG3842	ATPase activity
L4F93_RS05760	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L4F93_RS05795	COG3307	-O-antigen
L4F93_RS05800	COG0066	3-isopropylmalate dehydratase activity
L4F93_RS05805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L4F93_RS05820	COG4133	protoheme IX ABC transporter activity
L4F93_RS05825	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L4F93_RS05830	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L4F93_RS05835	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L4F93_RS05845	COG1138	Cytochrome C-type biogenesis protein
L4F93_RS05850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L4F93_RS05865	COG0346	lactoylglutathione lyase activity
L4F93_RS05875	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L4F93_RS05885	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L4F93_RS05890	COG3161	chorismate lyase activity
L4F93_RS05900	COG0107	imidazoleglycerol-phosphate synthase activity
L4F93_RS05910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L4F93_RS05920	COG4804	nuclease activity
L4F93_RS05925	COG0131	Imidazoleglycerol-phosphate dehydratase
L4F93_RS05925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L4F93_RS05940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L4F93_RS05950	COG2226	methyltransferase
L4F93_RS05955	COG0814	amino acid
L4F93_RS05965	COG4783	chaperone-mediated protein folding
L4F93_RS05975	COG4942	peptidase
L4F93_RS05975	COG1388	LysM domain
L4F93_RS05985	COG1238	metal cluster binding
L4F93_RS06010	COG1846	Transcriptional regulator
L4F93_RS06015	COG1566	PFAM secretion protein HlyD family protein
L4F93_RS06020	COG2814	Major facilitator Superfamily
L4F93_RS06045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L4F93_RS06070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L4F93_RS06075	COG3610	response to peptide
L4F93_RS06080	COG2966	Psort location CytoplasmicMembrane, score
L4F93_RS06085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L4F93_RS06090	COG2017	converts alpha-aldose to the beta-anomer
L4F93_RS06100	COG1085	galactose-1-phosphate uridylyltransferase
L4F93_RS06105	COG1609	Transcriptional regulator
L4F93_RS06110	COG1879	ABC-type sugar transport system periplasmic component
L4F93_RS06115	COG1129	ABC transporter
L4F93_RS06120	COG4211	Belongs to the binding-protein-dependent transport system permease family
L4F93_RS06125	COG4453	Protein conserved in bacteria
L4F93_RS06140	COG0752	glycyl-tRNA synthetase alpha subunit
L4F93_RS06150	COG4545	Glutaredoxin-related protein
L4F93_RS06155	COG4804	nuclease activity
L4F93_RS06170	COG1959	2 iron, 2 sulfur cluster binding
L4F93_RS06185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L4F93_RS06190	COG0084	hydrolase, TatD family'
L4F93_RS06195	COG0583	DNA-binding transcription factor activity
L4F93_RS06200	COG2249	NAD(P)H dehydrogenase (quinone) activity
L4F93_RS06210	COG4221	oxidoreductase activity
L4F93_RS06220	COG0602	queuosine metabolic process
L4F93_RS06225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L4F93_RS06225	COG1328	CTP reductase activity
L4F93_RS06230	COG1022	Amp-dependent synthetase and ligase
L4F93_RS06235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L4F93_RS06240	COG0194	GDP metabolic process
L4F93_RS06250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L4F93_RS06255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L4F93_RS06260	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L4F93_RS06295	COG1530	ribonuclease E activity
L4F93_RS06305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L4F93_RS06310	COG1917	Cupin 2, conserved barrel domain protein
L4F93_RS06310	COG4977	sequence-specific DNA binding
L4F93_RS06315	COG5413	integral membrane protein
L4F93_RS06335	COG1840	ABC-type Fe3 transport system, periplasmic component
L4F93_RS06365	COG1620	l-lactate permease
L4F93_RS06370	COG0247	lactate metabolic process
L4F93_RS06375	COG1139	Iron-sulfur cluster binding protein
L4F93_RS06380	COG1556	Lactate utilization protein
L4F93_RS06385	COG1217	gtp-binding protein TYPA
L4F93_RS06390	COG0174	glutamine synthetase
L4F93_RS06400	COG3036	rescue of stalled ribosome
L4F93_RS06405	COG1393	Belongs to the ArsC family
L4F93_RS06415	COG1126	abc transporter atp-binding protein
L4F93_RS06420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L4F93_RS06425	COG4215	(ABC) transporter
L4F93_RS06430	COG4160	amino acid transport
L4F93_RS06440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L4F93_RS06465	COG0105	UTP biosynthetic process
L4F93_RS06490	COG2198	Histidine kinase
L4F93_RS06490	COG5002	protein histidine kinase activity
L4F93_RS06490	COG0784	Response regulator, receiver
L4F93_RS06510	COG0494	nUDIX hydrolase
L4F93_RS06520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L4F93_RS06525	COG4137	Cytochrome C assembly protein
L4F93_RS06530	COG4536	flavin adenine dinucleotide binding
L4F93_RS06540	COG0811	peptide transport
L4F93_RS06545	COG0848	biopolymer transport protein
L4F93_RS06560	COG4178	(ABC) transporter
L4F93_RS06575	COG3549	Plasmid maintenance system killer
L4F93_RS06580	COG3093	addiction module antidote protein HigA
L4F93_RS06585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L4F93_RS06595	COG0861	Integral membrane protein TerC family
L4F93_RS06610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L4F93_RS06615	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
L4F93_RS06620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L4F93_RS06655	COG0495	leucyl-tRNA aminoacylation
L4F93_RS06660	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
L4F93_RS06665	COG1466	dna polymerase III delta subunit
L4F93_RS06670	COG2267	carboxylic ester hydrolase activity
L4F93_RS06685	COG0436	Aminotransferase
L4F93_RS06700	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
L4F93_RS06705	COG3091	SprT-like family
L4F93_RS06710	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L4F93_RS06715	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
L4F93_RS06720	COG0456	acetyltransferase
L4F93_RS06730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L4F93_RS06735	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
L4F93_RS06745	COG1882	Formate acetyltransferase
L4F93_RS06750	COG2116	formate transmembrane transporter activity
L4F93_RS06755	COG0537	adenosine 5'-monophosphoramidase activity
L4F93_RS06770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L4F93_RS06810	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L4F93_RS06830	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
L4F93_RS06840	COG2731	YhcH YjgK YiaL family protein
L4F93_RS06845	COG1737	Transcriptional regulator
L4F93_RS06850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L4F93_RS06865	COG0557	exoribonuclease II activity
L4F93_RS06880	COG2965	DNA replication, synthesis of RNA primer
L4F93_RS06885	COG0360	Binds together with S18 to 16S ribosomal RNA
L4F93_RS06900	COG0497	DNA recombination
L4F93_RS06915	COG0590	tRNA wobble adenosine to inosine editing
L4F93_RS06930	COG0730	response to heat
L4F93_RS06940	COG1230	cation diffusion facilitator family transporter
L4F93_RS06945	COG3023	N-Acetylmuramoyl-L-alanine amidase
L4F93_RS06950	COG4969	Belongs to the N-Me-Phe pilin family
L4F93_RS06955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L4F93_RS06965	COG1702	phosphate starvation-inducible protein PhoH
L4F93_RS06970	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L4F93_RS06975	COG1444	tRNA N-acetyltransferase activity
L4F93_RS06995	COG3116	cell division
L4F93_RS07000	COG0768	penicillin binding
L4F93_RS07010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L4F93_RS07020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L4F93_RS07045	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L4F93_RS07050	COG0849	cell division
L4F93_RS07055	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L4F93_RS07060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L4F93_RS07065	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
L4F93_RS07080	COG4221	oxidoreductase activity
L4F93_RS07090	COG1605	Chorismate mutase
L4F93_RS07090	COG0077	Prephenate dehydratase
L4F93_RS07095	COG2252	PERMEase
L4F93_RS07100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L4F93_RS07105	COG2814	Major facilitator Superfamily
L4F93_RS07110	COG0385	Bile acid
L4F93_RS07120	COG1793	dna ligase
L4F93_RS07125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L4F93_RS07130	COG0363	glucosamine-6-phosphate deaminase activity
L4F93_RS07135	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L4F93_RS07140	COG1940	carbohydrate kinase activity
L4F93_RS07140	COG1846	Transcriptional regulator
L4F93_RS07175	COG4771	TonB-dependent receptor
L4F93_RS07175	COG1629	transport
L4F93_RS07185	COG0339	signal peptide processing
L4F93_RS07190	COG2832	Protein of unknown function (DUF454)
L4F93_RS07195	COG4166	transmembrane transport
L4F93_RS07205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L4F93_RS07210	COG3112	Uncharacterised protein family (UPF0231)
L4F93_RS07215	COG0316	Belongs to the HesB IscA family
L4F93_RS07220	COG0024	Methionine aminopeptidase
L4F93_RS07235	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L4F93_RS07305	COG3077	Addiction module antitoxin, RelB DinJ family
L4F93_RS07310	COG3041	Addiction module toxin RelE StbE family
L4F93_RS07315	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L4F93_RS07320	COG0494	nUDIX hydrolase
L4F93_RS07330	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L4F93_RS07345	COG1929	Belongs to the glycerate kinase type-1 family
L4F93_RS07350	COG2610	gluconate transmembrane transporter activity
L4F93_RS07355	COG3835	regulator
L4F93_RS07365	COG0489	protein tyrosine kinase activity
L4F93_RS07370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L4F93_RS07370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L4F93_RS07375	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L4F93_RS07375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L4F93_RS07380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L4F93_RS07415	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L4F93_RS07420	COG2378	regulation of single-species biofilm formation
L4F93_RS07435	COG2056	Na+-H+ antiporter family
L4F93_RS07440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L4F93_RS07445	COG0346	lactoylglutathione lyase activity
L4F93_RS07455	COG0460	homoserine dehydrogenase
L4F93_RS07455	COG0527	aspartate kinase activity
L4F93_RS07460	COG0083	homoserine kinase activity
L4F93_RS07465	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L4F93_RS07470	COG1393	Belongs to the ArsC family
L4F93_RS07475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L4F93_RS07480	COG1876	peptidase activity
L4F93_RS07490	COG0494	nUDIX hydrolase
L4F93_RS07495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L4F93_RS07500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L4F93_RS07515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L4F93_RS07520	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L4F93_RS07525	COG0745	RESPONSE REGULATOR receiver
L4F93_RS07530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L4F93_RS07550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L4F93_RS07555	COG0626	cystathionine gamma-synthase activity
L4F93_RS07640	COG3210	domain, Protein
L4F93_RS07645	COG2831	hemolysin activation secretion protein
L4F93_RS07680	COG1518	maintenance of DNA repeat elements
L4F93_RS07700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L4F93_RS07710	COG2990	Protein conserved in bacteria
L4F93_RS07715	COG1522	sequence-specific DNA binding
L4F93_RS07720	COG1288	antiporter activity
L4F93_RS07725	COG0549	Belongs to the carbamate kinase family
L4F93_RS07740	COG0539	negative regulation of cytoplasmic translation
L4F93_RS07745	COG0776	regulation of translation
L4F93_RS07750	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
L4F93_RS07755	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
L4F93_RS07765	COG0023	Translation Initiation Factor
L4F93_RS07775	COG0436	Aminotransferase
L4F93_RS07780	COG3111	PFAM Bacterial OB fold (BOF) protein
L4F93_RS07785	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L4F93_RS07790	COG0745	RESPONSE REGULATOR receiver
L4F93_RS07795	COG0642	Histidine kinase
L4F93_RS07800	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
L4F93_RS07805	COG3094	Invasion gene expression up-regulator, SirB
L4F93_RS07810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L4F93_RS07820	COG0735	belongs to the Fur family
L4F93_RS07825	COG0716	FMN binding
L4F93_RS07835	COG0596	Alpha beta hydrolase
L4F93_RS07840	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
L4F93_RS07845	COG0318	PFAM AMP-dependent synthetase and ligase
L4F93_RS07850	COG3264	Mechanosensitive ion channel
L4F93_RS07850	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
L4F93_RS07860	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
L4F93_RS07865	COG0730	response to heat
L4F93_RS07870	COG1560	Kdo2-lipid A biosynthetic process
L4F93_RS07875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L4F93_RS07880	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L4F93_RS07885	COG1966	Carbon starvation protein
L4F93_RS07890	COG0673	inositol 2-dehydrogenase activity
L4F93_RS07895	COG4607	ABC-type enterochelin transport system periplasmic component
L4F93_RS07900	COG4604	ABC transporter, ATP-binding protein
L4F93_RS07905	COG4605	iron ion homeostasis
L4F93_RS07910	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L4F93_RS07925	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L4F93_RS07930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L4F93_RS07950	COG0469	pyruvate kinase activity
L4F93_RS07955	COG0778	Nitroreductase
L4F93_RS07965	COG2932	Transcriptional regulator
L4F93_RS07975	COG1119	ATPase activity
L4F93_RS07980	COG0330	HflC and HflK could
L4F93_RS07990	COG2249	NAD(P)H dehydrogenase (quinone) activity
L4F93_RS07995	COG3381	protein complex oligomerization
L4F93_RS08000	COG1560	Kdo2-lipid A biosynthetic process
L4F93_RS08005	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L4F93_RS08005	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L4F93_RS08020	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L4F93_RS08020	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L4F93_RS08025	COG0516	GMP reductase activity
L4F93_RS08025	COG0517	IMP dehydrogenase activity
L4F93_RS08030	COG0697	spore germination
L4F93_RS08035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L4F93_RS08035	COG0519	Catalyzes the synthesis of GMP from XMP
L4F93_RS08040	COG0488	(ABC) transporter
L4F93_RS08045	COG3683	transport system, periplasmic component
L4F93_RS08050	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
L4F93_RS08080	COG0281	malic enzyme
L4F93_RS08090	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L4F93_RS08095	COG1177	transmembrane transport
L4F93_RS08100	COG1176	ABC-type spermidine putrescine transport system, permease component I
L4F93_RS08105	COG3842	ATPase activity
L4F93_RS08120	COG4143	(ABC) transporter
L4F93_RS08125	COG1178	ABC-type Fe3 transport system permease component
L4F93_RS08130	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
L4F93_RS08140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L4F93_RS08145	COG0730	response to heat
L4F93_RS08160	COG1448	Aminotransferase
L4F93_RS08165	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L4F93_RS08170	COG0288	reversible hydration of carbon dioxide
L4F93_RS08175	COG0159	tryptophan synthase activity
L4F93_RS08185	COG0135	phosphoribosylanthranilate isomerase activity
L4F93_RS08185	COG0134	indole-3-glycerol-phosphate synthase activity
L4F93_RS08190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L4F93_RS08195	COG1942	4-Oxalocrotonate Tautomerase
L4F93_RS08200	COG0512	Glutamine amidotransferase of anthranilate synthase
L4F93_RS08205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L4F93_RS08215	COG2927	DNA polymerase III (CHI subunit)
L4F93_RS08220	COG2153	protein acetylation
L4F93_RS08230	COG4185	zeta toxin
L4F93_RS08240	COG0525	valine-tRNA ligase activity
L4F93_RS08245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L4F93_RS08260	COG0582	viral genome integration into host DNA
L4F93_RS08355	COG4197	protein conserved in bacteria, prophage-related
L4F93_RS08375	COG3772	lysozyme
L4F93_RS08395	COG4626	Terminase
L4F93_RS08395	COG1802	Transcriptional regulator
L4F93_RS08400	COG4695	Portal protein
L4F93_RS08525	COG0305	Participates in initiation and elongation during chromosome replication
L4F93_RS08930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L4F93_RS08985	COG3501	Rhs element vgr protein
L4F93_RS09030	COG3501	Rhs element vgr protein
L4F93_RS09045	COG3501	Rhs element vgr protein
L4F93_RS09050	COG3676	manually curated
L4F93_RS09065	COG3501	Rhs element vgr protein
L4F93_RS09090	COG3676	manually curated
L4F93_RS09115	COG3501	Rhs element vgr protein
L4F93_RS09145	COG3501	Rhs element vgr protein
L4F93_RS09165	COG3501	Rhs element vgr protein
L4F93_RS09210	COG2814	Major facilitator Superfamily
L4F93_RS09215	COG4221	oxidoreductase activity
L4F93_RS09220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L4F93_RS09230	COG0741	lytic transglycosylase activity
L4F93_RS09235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L4F93_RS09240	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L4F93_RS09245	COG1862	Preprotein translocase
L4F93_RS09250	COG3945	hemerythrin HHE cation binding domain
L4F93_RS09265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L4F93_RS09270	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L4F93_RS09270	COG0506	proline dehydrogenase activity
L4F93_RS09270	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L4F93_RS09275	COG0826	peptidase U32
L4F93_RS09280	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L4F93_RS09285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L4F93_RS09305	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L4F93_RS09315	COG3676	manually curated
L4F93_RS09330	COG0601	transmembrane transport
L4F93_RS09335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L4F93_RS09345	COG4608	Belongs to the ABC transporter superfamily
L4F93_RS09350	COG2823	Periplasmic or secreted lipoprotein
L4F93_RS09355	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L4F93_RS09360	COG0792	nuclease activity
L4F93_RS09375	COG0009	L-threonylcarbamoyladenylate synthase
L4F93_RS09385	COG0583	DNA-binding transcription factor activity
L4F93_RS09390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L4F93_RS09395	COG4591	ABC-type transport system involved in lipoprotein release permease component
L4F93_RS09405	COG4591	ABC-type transport system involved in lipoprotein release permease component
L4F93_RS09410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L4F93_RS09420	COG2949	membrane
L4F93_RS09425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L4F93_RS09430	COG0733	neurotransmitter:sodium symporter activity
L4F93_RS09435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L4F93_RS09450	COG4658	electron transport chain
L4F93_RS09455	COG4656	Part of a membrane complex involved in electron transport
L4F93_RS09480	COG1090	epimerase
L4F93_RS09485	COG1438	arginine binding
L4F93_RS09490	COG0039	L-malate dehydrogenase activity
L4F93_RS09495	COG1609	Transcriptional regulator
L4F93_RS09510	COG0795	lipopolysaccharide-transporting ATPase activity
L4F93_RS09515	COG0795	lipopolysaccharide-transporting ATPase activity
L4F93_RS09520	COG0668	transmembrane transport
L4F93_RS09555	COG3133	Outer membrane lipoprotein
L4F93_RS09560	COG0305	Participates in initiation and elongation during chromosome replication
L4F93_RS09575	COG2964	Protein conserved in bacteria
L4F93_RS09580	COG0814	amino acid
L4F93_RS09615	COG0450	alkyl hydroperoxide reductase
L4F93_RS09620	COG0626	cystathionine gamma-synthase activity
L4F93_RS09625	COG1840	ABC-type Fe3 transport system, periplasmic component
L4F93_RS09630	COG1408	metallophosphoesterase
L4F93_RS09635	COG1840	ABC-type Fe3 transport system, periplasmic component
L4F93_RS09640	COG1049	propionate catabolic process, 2-methylcitrate cycle
L4F93_RS09645	COG2350	Protein conserved in bacteria
L4F93_RS09650	COG1607	acyl-coa hydrolase
L4F93_RS09665	COG0277	FAD linked oxidase domain protein
L4F93_RS09680	COG0305	Participates in initiation and elongation during chromosome replication
L4F93_RS09980	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L4F93_RS09985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L4F93_RS09995	COG0247	lactate metabolic process
L4F93_RS09995	COG0277	FAD linked oxidase domain protein
L4F93_RS10005	COG1704	LemA family
L4F93_RS10030	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L4F93_RS10040	COG2062	phosphohistidine phosphatase, SixA
L4F93_RS10045	COG1823	symporter activity
L4F93_RS10055	COG3021	interspecies interaction between organisms
L4F93_RS10060	COG0251	oxidation-reduction process
L4F93_RS10075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L4F93_RS10080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L4F93_RS10085	COG1328	CTP reductase activity
L4F93_RS10090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L4F93_RS10100	COG0187	DNA topoisomerase II activity
L4F93_RS10105	COG3008	intermembrane lipid transfer
L4F93_RS10110	COG2995	paraquat-inducible protein a
L4F93_RS10125	COG0793	Belongs to the peptidase S41A family
L4F93_RS10130	COG2989	Protein conserved in bacteria
L4F93_RS10135	COG3108	Peptidase M15
L4F93_RS10140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L4F93_RS10145	COG4783	chaperone-mediated protein folding
L4F93_RS10165	COG2358	TRAP transporter, solute receptor (TAXI family
L4F93_RS10180	COG0567	Dehydrogenase, E1 component
L4F93_RS10185	COG0508	dehydrogenase complex catalyzes the overall conversion of
L4F93_RS10190	COG0045	succinate-CoA ligase (ADP-forming) activity
L4F93_RS10195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L4F93_RS10205	COG2826	transposase and inactivated derivatives, IS30 family
L4F93_RS10210	COG4206	TonB-dependent receptor
L4F93_RS10225	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
L4F93_RS10250	COG0037	tRNA processing
L4F93_RS10260	COG0825	malonyl-CoA metabolic process
L4F93_RS10280	COG0671	phosphoesterase, PA-phosphatase related
L4F93_RS10285	COG1940	carbohydrate kinase activity
L4F93_RS10295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L4F93_RS10300	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L4F93_RS10305	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L4F93_RS10310	COG1280	lysine exporter protein (LysE YggA)
L4F93_RS10320	COG0633	Ferredoxin
L4F93_RS10330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L4F93_RS10335	COG3105	Protein conserved in bacteria
L4F93_RS10340	COG1944	ATP diphosphatase activity
L4F93_RS10345	COG2226	methyltransferase
L4F93_RS10350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L4F93_RS10355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L4F93_RS10370	COG0788	formyltetrahydrofolate deformylase activity
L4F93_RS10375	COG2916	Histone family protein nucleoid-structuring protein H-NS
L4F93_RS10380	COG1757	Na H antiporter
L4F93_RS10385	COG0028	Belongs to the TPP enzyme family
L4F93_RS10390	COG0440	acetolactate synthase activity
L4F93_RS10395	COG0039	L-malate dehydrogenase activity
L4F93_RS10400	COG0583	DNA-binding transcription factor activity
L4F93_RS10405	COG4224	UPF0291 protein
L4F93_RS10425	COG0633	Ferredoxin
L4F93_RS10425	COG3217	Mosc domain protein beta barrel domain protein
L4F93_RS10430	COG2027	D-alanyl-D-alanine carboxypeptidase
L4F93_RS10435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L4F93_RS10440	COG1534	Rna-binding protein
L4F93_RS10450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L4F93_RS10460	COG2912	Transglutaminase-like superfamily
L4F93_RS10475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L4F93_RS10485	COG2863	cytochrome
L4F93_RS10495	COG1199	ATP-dependent helicase activity
L4F93_RS10500	COG1214	PFAM Peptidase M22, glycoprotease
L4F93_RS10505	COG0318	PFAM AMP-dependent synthetase and ligase
L4F93_RS10510	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
L4F93_RS10525	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L4F93_RS10530	COG4988	ABC transporter
L4F93_RS10535	COG0492	ferredoxin-NADP+ reductase activity
L4F93_RS10540	COG3118	belongs to the thioredoxin family
L4F93_RS10545	COG2610	gluconate transmembrane transporter activity
L4F93_RS10550	COG3265	gluconokinase activity
L4F93_RS10555	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
L4F93_RS10565	COG0488	(ABC) transporter
L4F93_RS10575	COG0142	geranyltranstransferase activity
L4F93_RS10580	COG1722	exodeoxyribonuclease VII activity
L4F93_RS10585	COG0301	tRNA thio-modification
L4F93_RS10585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L4F93_RS10590	COG0778	Nitroreductase
L4F93_RS10600	COG0616	signal peptide processing
L4F93_RS10605	COG0583	DNA-binding transcription factor activity
L4F93_RS10630	COG1162	GTPase activity
L4F93_RS10635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L4F93_RS10640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L4F93_RS10645	COG2190	(PTS) system
L4F93_RS10650	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L4F93_RS10655	COG0508	dehydrogenase complex catalyzes the overall conversion of
L4F93_RS10660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L4F93_RS10665	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L4F93_RS10670	COG3119	arylsulfatase activity
L4F93_RS10675	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L4F93_RS10680	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L4F93_RS10680	COG0517	IMP dehydrogenase activity
L4F93_RS10705	COG1067	ATP-dependent peptidase activity
L4F93_RS10715	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L4F93_RS10720	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L4F93_RS10725	COG2252	PERMEase
L4F93_RS10730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L4F93_RS10740	COG3101	peptidyl-lysine hydroxylation
L4F93_RS10745	COG1131	(ABC) transporter
L4F93_RS10750	COG0842	Transport permease protein
L4F93_RS10755	COG1611	Belongs to the LOG family
L4F93_RS10760	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L4F93_RS10760	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L4F93_RS10770	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
L4F93_RS10775	COG3098	single-species biofilm formation
L4F93_RS10780	COG0564	pseudouridine synthase activity
L4F93_RS10800	COG2969	positive regulation of protein catabolic process
L4F93_RS10805	COG2925	Exonuclease
L4F93_RS10810	COG0697	spore germination
L4F93_RS10840	COG0037	tRNA processing
L4F93_RS10845	COG0791	NLP P60 protein
L4F93_RS10850	COG0776	regulation of translation
L4F93_RS10855	COG0072	phenylalanine-tRNA ligase activity
L4F93_RS10855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L4F93_RS10865	COG0564	pseudouridine synthase activity
L4F93_RS10875	COG0588	phosphoglycerate mutase activity
L4F93_RS10895	COG1940	carbohydrate kinase activity
L4F93_RS10915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L4F93_RS10920	COG1074	ATP-dependent DNA helicase activity
L4F93_RS10925	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L4F93_RS10945	COG1523	belongs to the glycosyl hydrolase 13 family
L4F93_RS10955	COG1640	4-alpha-glucanotransferase
L4F93_RS10960	COG3657	addiction module killer protein
L4F93_RS10965	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L4F93_RS10980	COG2920	part of a sulfur-relay system
L4F93_RS10990	COG1121	(ABC) transporter
L4F93_RS10995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L4F93_RS11000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L4F93_RS11020	COG1289	transmembrane transporter activity
L4F93_RS11025	COG1278	Cold shock
L4F93_RS11030	COG3140	Belongs to the UPF0181 family
L4F93_RS11035	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L4F93_RS11040	COG0285	dihydrofolate synthase activity
L4F93_RS11070	COG0163	prenyltransferase activity
L4F93_RS11080	COG1286	toxin biosynthetic process
L4F93_RS11085	COG3092	negative regulation of chromosome organization
L4F93_RS11095	COG0857	belongs to the CobB CobQ family
L4F93_RS11095	COG0280	phosphate acetyltransferase
L4F93_RS11150	COG3093	addiction module antidote protein HigA
L4F93_RS11260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L4F93_RS11280	COG1783	phage Terminase large subunit
L4F93_RS11285	COG3728	DNA packaging
L4F93_RS11310	COG3772	lysozyme
L4F93_RS11335	COG3617	BRO family, N-terminal domain
L4F93_RS11360	COG1846	Transcriptional regulator
L4F93_RS11520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L4F93_RS11525	COG0577	efflux transmembrane transporter activity
L4F93_RS11525	COG1136	(ABC) transporter
L4F93_RS11530	COG1538	Outer membrane efflux protein
L4F93_RS11540	COG0583	DNA-binding transcription factor activity
L4F93_RS11545	COG0656	L-ascorbic acid biosynthetic process
L4F93_RS11550	COG1846	Transcriptional regulator
L4F93_RS11555	COG1764	response to oxidative stress
L4F93_RS11600	COG1902	pentaerythritol trinitrate reductase activity
L4F93_RS11625	COG0583	DNA-binding transcription factor activity
L4F93_RS11630	COG2272	Belongs to the type-B carboxylesterase lipase family
L4F93_RS11635	COG2962	Rard protein
L4F93_RS11640	COG0287	Prephenate dehydrogenase
L4F93_RS11640	COG1605	Chorismate mutase
L4F93_RS11645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L4F93_RS11650	COG0613	PHP domain protein
L4F93_RS11655	COG0167	dihydroorotate dehydrogenase activity
L4F93_RS11660	COG0308	aminopeptidase N
L4F93_RS11665	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L4F93_RS11685	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L4F93_RS11700	COG1522	sequence-specific DNA binding
L4F93_RS11715	COG1346	cytolysis
L4F93_RS11720	COG1380	Effector of murein hydrolase LrgA
L4F93_RS11725	COG1525	nuclease
L4F93_RS11735	COG2166	iron-sulfur cluster assembly
L4F93_RS11740	COG2268	Band 7 protein
L4F93_RS11755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L4F93_RS11770	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L4F93_RS11775	COG0617	tRNA 3'-terminal CCA addition
L4F93_RS11780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L4F93_RS11785	COG1609	Transcriptional regulator
L4F93_RS11790	COG1263	PTS System
L4F93_RS11790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L4F93_RS11795	COG0366	Alpha amylase catalytic
L4F93_RS11800	COG5005	Phage virion morphogenesis
L4F93_RS11805	COG2369	cell adhesion
L4F93_RS11840	COG0314	molybdopterin synthase activity
L4F93_RS11845	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
L4F93_RS11870	COG0303	'Molybdopterin
L4F93_RS11875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L4F93_RS11880	COG3593	DNA synthesis involved in DNA repair
L4F93_RS11885	COG2431	L-lysine efflux transmembrane transporter activity
L4F93_RS11890	COG1528	Iron-storage protein
L4F93_RS11895	COG1528	Iron-storage protein
L4F93_RS11905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L4F93_RS11910	COG0589	response to stress
L4F93_RS11920	COG0616	signal peptide processing
L4F93_RS11930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L4F93_RS11935	COG3676	manually curated
L4F93_RS11955	COG0322	excinuclease ABC activity
L4F93_RS11965	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L4F93_RS11970	COG2835	tetraacyldisaccharide 4'-kinase activity
L4F93_RS11975	COG1663	tetraacyldisaccharide 4'-kinase activity
L4F93_RS11980	COG1132	(ABC) transporter
L4F93_RS11985	COG2333	competence protein COMEC
L4F93_RS11985	COG0658	competence protein
L4F93_RS11995	COG0351	phosphomethylpyrimidine kinase
L4F93_RS12000	COG0352	thiamine-phosphate diphosphorylase activity
L4F93_RS12010	COG3266	domain, Protein
L4F93_RS12010	COG3468	outer membrane autotransporter barrel domain protein
L4F93_RS12015	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L4F93_RS12020	COG3025	triphosphatase activity
L4F93_RS12025	COG1392	Phosphate transport regulator
L4F93_RS12030	COG0306	phosphate transporter
L4F93_RS12035	COG4991	sh3 domain protein
L4F93_RS12040	COG0617	tRNA 3'-terminal CCA addition
L4F93_RS12045	COG3955	Domain of unknown function (DUF1919)
L4F93_RS12055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L4F93_RS12060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L4F93_RS12060	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L4F93_RS12080	COG4149	molybdate abc transporter
L4F93_RS12085	COG0725	ABC transporter, periplasmic molybdate-binding protein
L4F93_RS12090	COG2005	Transcriptional regulator
L4F93_RS12105	COG1687	branched-chain amino acid
L4F93_RS12110	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L4F93_RS12115	COG0583	DNA-binding transcription factor activity
L4F93_RS12125	COG0210	DNA helicase
L4F93_RS12135	COG0583	DNA-binding transcription factor activity
L4F93_RS12140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L4F93_RS12145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L4F93_RS12150	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L4F93_RS12160	COG0195	Participates in both transcription termination and antitermination
L4F93_RS12175	COG0515	serine threonine protein kinase
L4F93_RS12180	COG1115	amino acid carrier protein
L4F93_RS12185	COG1028	Short-chain dehydrogenase reductase Sdr
L4F93_RS12190	COG0814	amino acid
L4F93_RS12195	COG0737	Belongs to the 5'-nucleotidase family
L4F93_RS12215	COG2910	NAD(P)H-binding
L4F93_RS12220	COG1733	regulation of RNA biosynthetic process
L4F93_RS12230	COG2999	glutathione oxidoreductase activity
L4F93_RS12255	COG0672	)-iron permease
L4F93_RS12265	COG1943	Transposase
L4F93_RS12275	COG0577	efflux transmembrane transporter activity
L4F93_RS12275	COG1136	(ABC) transporter
L4F93_RS12285	COG1136	(ABC) transporter
L4F93_RS12290	COG0676	glucose-6-phosphate 1-epimerase activity
L4F93_RS12300	COG0307	riboflavin synthase, alpha
L4F93_RS12310	COG0673	inositol 2-dehydrogenase activity
L4F93_RS12315	COG4774	siderophore transport
L4F93_RS12320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L4F93_RS12325	COG0586	Pfam SNARE associated Golgi protein
L4F93_RS12330	COG3100	YcgL domain-containing protein
L4F93_RS12335	COG0243	molybdopterin cofactor binding
L4F93_RS12340	COG3005	denitrification pathway
L4F93_RS12350	COG0708	Exodeoxyribonuclease III
L4F93_RS12355	COG1946	Acyl-CoA thioesterase
L4F93_RS12360	COG2833	Protein of unknown function (DUF455)
L4F93_RS12365	COG2951	lytic endotransglycosylase activity
L4F93_RS12370	COG1216	Glycosyl transferase, family 2
L4F93_RS12375	COG1216	Glycosyl transferase, family 2
L4F93_RS12385	COG3306	glycosyltransferase involved in LPS biosynthesis
L4F93_RS12395	COG5039	Polysaccharide pyruvyl transferase
L4F93_RS12400	COG0305	Participates in initiation and elongation during chromosome replication