locus-tag	class	description
CEW83_RS00010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CEW83_RS00015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEW83_RS00020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CEW83_RS00025	COG0573	inorganic phosphate transmembrane transporter activity
CEW83_RS00030	COG0581	inorganic phosphate transmembrane transporter activity
CEW83_RS00045	COG0149	triose-phosphate isomerase activity
CEW83_RS00060	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CEW83_RS00065	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CEW83_RS00070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CEW83_RS00075	COG0649	NAD binding
CEW83_RS00080	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CEW83_RS00085	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CEW83_RS00090	COG1034	ATP synthesis coupled electron transport
CEW83_RS00095	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CEW83_RS00100	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CEW83_RS00110	COG0713	ATP synthesis coupled electron transport
CEW83_RS00125	COG1007	ATP synthesis coupled electron transport
CEW83_RS00140	COG0657	acetylesterase activity
CEW83_RS00150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CEW83_RS00155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW83_RS00160	COG1129	ABC transporter
CEW83_RS00160	COG0842	Transport permease protein
CEW83_RS00165	COG0842	Transport permease protein
CEW83_RS00185	COG0330	HflC and HflK could
CEW83_RS00195	COG1126	abc transporter atp-binding protein
CEW83_RS00200	COG0765	amino acid transport
CEW83_RS00205	COG0765	amino acid transport
CEW83_RS00220	COG2200	EAL domain
CEW83_RS00225	COG1522	sequence-specific DNA binding
CEW83_RS00235	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CEW83_RS00240	COG0583	DNA-binding transcription factor activity
CEW83_RS00255	COG0564	pseudouridine synthase activity
CEW83_RS00270	COG3243	poly(R)-hydroxyalkanoic acid synthase
CEW83_RS00275	COG1028	Short-chain dehydrogenase reductase Sdr
CEW83_RS00285	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CEW83_RS00290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CEW83_RS00295	COG1752	Esterase of the alpha-beta hydrolase superfamily
CEW83_RS00300	COG0277	FAD linked oxidase domain protein
CEW83_RS00340	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CEW83_RS00345	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW83_RS00350	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CEW83_RS00360	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CEW83_RS00370	COG0318	PFAM AMP-dependent synthetase and ligase
CEW83_RS00375	COG0028	Belongs to the TPP enzyme family
CEW83_RS00380	COG0440	acetolactate synthase activity
CEW83_RS00385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CEW83_RS00400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CEW83_RS00405	COG0066	3-isopropylmalate dehydratase activity
CEW83_RS00410	COG0473	3-isopropylmalate dehydrogenase activity
CEW83_RS00430	COG0101	tRNA pseudouridine synthase activity
CEW83_RS00435	COG0135	phosphoribosylanthranilate isomerase activity
CEW83_RS00440	COG0133	tryptophan synthase activity
CEW83_RS00445	COG0159	tryptophan synthase activity
CEW83_RS00450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CEW83_RS00455	COG0285	dihydrofolate synthase activity
CEW83_RS00480	COG2239	Acts as a magnesium transporter
CEW83_RS00490	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEW83_RS00495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CEW83_RS00500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CEW83_RS00505	COG0215	cysteine-tRNA ligase activity
CEW83_RS00515	COG0484	heat shock protein binding
CEW83_RS00520	COG0443	Heat shock 70 kDa protein
CEW83_RS00525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CEW83_RS00535	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CEW83_RS00545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CEW83_RS00550	COG0287	Prephenate dehydrogenase
CEW83_RS00555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CEW83_RS00565	COG0776	regulation of translation
CEW83_RS00575	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CEW83_RS00615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CEW83_RS00620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CEW83_RS00625	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CEW83_RS00630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CEW83_RS00635	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CEW83_RS00640	COG0072	phenylalanine-tRNA ligase activity
CEW83_RS00640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEW83_RS00645	COG0776	regulation of translation
CEW83_RS00665	COG0494	nUDIX hydrolase
CEW83_RS00670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEW83_RS00675	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CEW83_RS00680	COG1760	l-serine dehydratase
CEW83_RS00685	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CEW83_RS00690	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CEW83_RS00720	COG1773	rubredoxin
CEW83_RS00740	COG0375	protein maturation
CEW83_RS00750	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CEW83_RS00755	COG0298	carbon dioxide binding
CEW83_RS00760	COG0409	Hydrogenase expression formation protein
CEW83_RS00765	COG0309	Hydrogenase expression formation protein (HypE)
CEW83_RS00770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CEW83_RS00770	COG1024	Enoyl-CoA hydratase
CEW83_RS00775	COG2204	response regulator
CEW83_RS00780	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CEW83_RS00800	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CEW83_RS00805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CEW83_RS00820	COG2951	lytic endotransglycosylase activity
CEW83_RS00835	COG0714	Associated with various cellular activities
CEW83_RS00840	COG0123	including yeast histone deacetylase and acetoin utilization protein
CEW83_RS00845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CEW83_RS00850	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CEW83_RS00865	COG2850	peptidyl-arginine hydroxylation
CEW83_RS00870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CEW83_RS00880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CEW83_RS00885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CEW83_RS00900	COG0154	amidase activity
CEW83_RS00905	COG0444	Belongs to the ABC transporter superfamily
CEW83_RS00910	COG4608	Belongs to the ABC transporter superfamily
CEW83_RS00915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW83_RS00920	COG0601	transmembrane transport
CEW83_RS00925	COG0747	negative chemotaxis
CEW83_RS00950	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CEW83_RS00965	COG1191	sigma factor activity
CEW83_RS00970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CEW83_RS00975	COG1360	Flagellar Motor Protein
CEW83_RS01000	COG0187	DNA topoisomerase II activity
CEW83_RS01020	COG1815	bacterial-type flagellum-dependent cell motility
CEW83_RS01030	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CEW83_RS01035	COG1749	Flagellar hook protein flgE
CEW83_RS01040	COG4787	bacterial-type flagellum-dependent cell motility
CEW83_RS01050	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CEW83_RS01055	COG1706	bacterial-type flagellum-dependent cell motility
CEW83_RS01060	COG3951	Flagellar rod assembly protein muramidase FlgJ
CEW83_RS01060	COG1705	Flagellar rod assembly protein muramidase FlgJ
CEW83_RS01085	COG1987	bacterial-type flagellum assembly
CEW83_RS01100	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CEW83_RS01115	COG3144	bacterial-type flagellum assembly
CEW83_RS01145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEW83_RS01150	COG4215	(ABC) transporter
CEW83_RS01155	COG4160	amino acid transport
CEW83_RS01185	COG2814	Major facilitator Superfamily
CEW83_RS01195	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CEW83_RS01200	COG0471	metal ion transport
CEW83_RS01205	COG4181	ATPase activity
CEW83_RS01240	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CEW83_RS01265	COG3706	GGDEF domain
CEW83_RS01265	COG2203	Gaf domain
CEW83_RS01265	COG4251	negative regulation of phosphorylation
CEW83_RS01265	COG5001	Diguanylate cyclase
CEW83_RS01270	COG0745	RESPONSE REGULATOR receiver
CEW83_RS01280	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CEW83_RS01285	COG0504	CTP synthase activity
CEW83_RS01290	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CEW83_RS01295	COG0148	phosphopyruvate hydratase activity
CEW83_RS01300	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CEW83_RS01310	COG0791	NLP P60 protein
CEW83_RS01320	COG0697	spore germination
CEW83_RS01335	COG2814	Major facilitator Superfamily
CEW83_RS01340	COG0583	DNA-binding transcription factor activity
CEW83_RS01355	COG0039	L-malate dehydrogenase activity
CEW83_RS01375	COG1053	succinate dehydrogenase
CEW83_RS01380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CEW83_RS01385	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CEW83_RS01390	COG0372	Belongs to the citrate synthase family
CEW83_RS01395	COG0567	Dehydrogenase, E1 component
CEW83_RS01400	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEW83_RS01405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEW83_RS01410	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CEW83_RS01480	COG1199	ATP-dependent helicase activity
CEW83_RS01485	COG1763	Mo-molybdopterin cofactor biosynthetic process
CEW83_RS01490	COG0303	'Molybdopterin
CEW83_RS01495	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CEW83_RS01500	COG0314	molybdopterin synthase activity
CEW83_RS01510	COG0741	lytic transglycosylase activity
CEW83_RS01510	COG1388	LysM domain
CEW83_RS01515	COG2203	Gaf domain
CEW83_RS01515	COG3706	GGDEF domain
CEW83_RS01515	COG4251	negative regulation of phosphorylation
CEW83_RS01515	COG5001	Diguanylate cyclase
CEW83_RS01525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEW83_RS01530	COG2226	methyltransferase
CEW83_RS01535	COG0328	RNA-DNA hybrid ribonuclease activity
CEW83_RS01545	COG0517	IMP dehydrogenase activity
CEW83_RS01560	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CEW83_RS01610	COG3045	CreA protein
CEW83_RS01645	COG0840	transmembrane signaling receptor activity
CEW83_RS01655	COG2032	superoxide dismutase activity
CEW83_RS01670	COG4176	ABC-type proline glycine betaine transport system permease component
CEW83_RS01675	COG2113	Glycine betaine
CEW83_RS01680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CEW83_RS01690	COG0330	HflC and HflK could
CEW83_RS01705	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEW83_RS01710	COG2197	response regulator
CEW83_RS01740	COG3790	cyd operon protein YbgE
CEW83_RS01750	COG1294	oxidase, subunit
CEW83_RS01770	COG0723	plastoquinol--plastocyanin reductase activity
CEW83_RS01790	COG0450	alkyl hydroperoxide reductase
CEW83_RS01800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEW83_RS01815	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEW83_RS01825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEW83_RS01835	COG3608	succinylglutamate desuccinylase aspartoacylase
CEW83_RS01840	COG0006	proline dipeptidase activity
CEW83_RS01845	COG0006	proline dipeptidase activity
CEW83_RS01850	COG2423	ornithine cyclodeaminase activity
CEW83_RS01855	COG2186	Transcriptional regulator
CEW83_RS01860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CEW83_RS01870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW83_RS01875	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW83_RS01880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW83_RS01895	COG2989	Protein conserved in bacteria
CEW83_RS01910	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CEW83_RS01915	COG0730	response to heat
CEW83_RS01920	COG0583	DNA-binding transcription factor activity
CEW83_RS01940	COG3622	Belongs to the hyi family
CEW83_RS01945	COG0697	spore germination
CEW83_RS01950	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CEW83_RS01955	COG4266	Belongs to the allantoicase family
CEW83_RS01980	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CEW83_RS01985	COG4266	Belongs to the allantoicase family
CEW83_RS02000	COG2351	hydroxyisourate hydrolase activity
CEW83_RS02035	COG1309	transcriptional regulator
CEW83_RS02055	COG2860	membrane
CEW83_RS02095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CEW83_RS02105	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CEW83_RS02110	COG0583	DNA-binding transcription factor activity
CEW83_RS02120	COG2217	Heavy metal translocating P-type atpase
CEW83_RS02130	COG3278	Belongs to the heme-copper respiratory oxidase family
CEW83_RS02175	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CEW83_RS02180	COG3243	poly(R)-hydroxyalkanoic acid synthase
CEW83_RS02185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CEW83_RS02195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CEW83_RS02200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CEW83_RS02215	COG2217	Heavy metal translocating P-type atpase
CEW83_RS02225	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CEW83_RS02240	COG2130	NADP-dependent
CEW83_RS02245	COG1979	alcohol dehydrogenase
CEW83_RS02250	COG1309	transcriptional regulator
CEW83_RS02265	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CEW83_RS02265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW83_RS02270	COG0347	Belongs to the P(II) protein family
CEW83_RS02275	COG2840	Smr protein MutS2
CEW83_RS02280	COG0492	ferredoxin-NADP+ reductase activity
CEW83_RS02290	COG1674	ftsk spoiiie
CEW83_RS02295	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CEW83_RS02300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CEW83_RS02310	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CEW83_RS02315	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CEW83_RS02345	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CEW83_RS02360	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CEW83_RS02445	COG3383	formate dehydrogenase (NAD+) activity
CEW83_RS02455	COG1960	acyl-CoA dehydrogenase activity
CEW83_RS02460	COG1960	acyl-CoA dehydrogenase activity
CEW83_RS02465	COG1024	Enoyl-CoA hydratase
CEW83_RS02470	COG1960	acyl-CoA dehydrogenase activity
CEW83_RS02475	COG0302	gtp cyclohydrolase
CEW83_RS02500	COG0583	DNA-binding transcription factor activity
CEW83_RS02510	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CEW83_RS02575	COG1028	Short-chain dehydrogenase reductase Sdr
CEW83_RS02580	COG0179	Fumarylacetoacetate (FAA) hydrolase
CEW83_RS02635	COG0179	Fumarylacetoacetate (FAA) hydrolase
CEW83_RS02640	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW83_RS02645	COG0183	Belongs to the thiolase family
CEW83_RS02680	COG1024	Enoyl-CoA hydratase
CEW83_RS02685	COG1028	Short-chain dehydrogenase reductase Sdr
CEW83_RS02705	COG2814	Major facilitator Superfamily
CEW83_RS02725	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CEW83_RS02730	COG4638	Rieske (2fe-2S)
CEW83_RS02735	COG1028	Short-chain dehydrogenase reductase Sdr
CEW83_RS02760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEW83_RS02775	COG2084	Dehydrogenase
CEW83_RS02780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW83_RS02785	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW83_RS02790	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW83_RS02795	COG1028	Short-chain dehydrogenase reductase Sdr
CEW83_RS02800	COG3958	Transketolase
CEW83_RS02805	COG3959	Transketolase, thiamine diphosphate binding domain
CEW83_RS02810	COG0583	DNA-binding transcription factor activity
CEW83_RS02830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW83_RS02840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW83_RS02850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEW83_RS02875	COG2346	COG2346, Truncated hemoglobins
CEW83_RS02885	COG0167	dihydroorotate dehydrogenase activity
CEW83_RS02890	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CEW83_RS02890	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CEW83_RS02890	COG1013	pyruvate-flavodoxin oxidoreductase activity
CEW83_RS02890	COG0674	pyruvate-flavodoxin oxidoreductase activity
CEW83_RS02895	COG1418	mRNA catabolic process
CEW83_RS02900	COG0348	domain, Protein
CEW83_RS02905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEW83_RS02925	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CEW83_RS02930	COG0066	3-isopropylmalate dehydratase activity
CEW83_RS02940	COG0583	DNA-binding transcription factor activity
CEW83_RS02945	COG2828	Protein conserved in bacteria
CEW83_RS02960	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CEW83_RS02965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CEW83_RS03000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEW83_RS03005	COG2828	Protein conserved in bacteria
CEW83_RS03015	COG0702	epimerase
CEW83_RS03035	COG2918	glutathione biosynthetic process
CEW83_RS03050	COG2133	pyrroloquinoline quinone binding
CEW83_RS03050	COG5183	chlorophyll binding
CEW83_RS03100	COG1222	aaa ATPase
CEW83_RS03140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CEW83_RS03145	COG0642	Histidine kinase
CEW83_RS03165	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CEW83_RS03180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW83_RS03180	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW83_RS03185	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW83_RS03185	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW83_RS03190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW83_RS03195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW83_RS03205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEW83_RS03210	COG2022	thiamine diphosphate biosynthetic process
CEW83_RS03220	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CEW83_RS03225	COG2855	membrane
CEW83_RS03235	COG1414	Transcriptional regulator
CEW83_RS03295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CEW83_RS03300	COG2823	Periplasmic or secreted lipoprotein
CEW83_RS03345	COG1414	Transcriptional regulator
CEW83_RS03350	COG0730	response to heat
CEW83_RS03365	COG1414	Transcriptional regulator
CEW83_RS03370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW83_RS03375	COG0242	peptide deformylase activity
CEW83_RS03385	COG0583	DNA-binding transcription factor activity
CEW83_RS03390	COG1960	acyl-CoA dehydrogenase activity
CEW83_RS03395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CEW83_RS03410	COG0840	transmembrane signaling receptor activity
CEW83_RS03425	COG3220	belongs to the UPF0276 family
CEW83_RS03475	COG0411	ABC transporter
CEW83_RS03505	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CEW83_RS03535	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CEW83_RS03540	COG0300	oxidoreductase activity
CEW83_RS03550	COG0318	PFAM AMP-dependent synthetase and ligase
CEW83_RS03555	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CEW83_RS03585	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CEW83_RS03595	COG0596	Alpha beta hydrolase
CEW83_RS03595	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEW83_RS03600	COG3384	dioxygenase
CEW83_RS03605	COG3971	2-oxopent-4-enoate hydratase activity
CEW83_RS03610	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CEW83_RS03615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEW83_RS03620	COG1063	alcohol dehydrogenase
CEW83_RS03630	COG1802	Transcriptional regulator
CEW83_RS03645	COG0346	lactoylglutathione lyase activity
CEW83_RS03670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CEW83_RS03680	COG0633	Ferredoxin
CEW83_RS03680	COG0543	2 iron, 2 sulfur cluster binding
CEW83_RS03720	COG0583	DNA-binding transcription factor activity
CEW83_RS03750	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CEW83_RS03755	COG5001	Diguanylate cyclase
CEW83_RS03755	COG3300	MHYT domain
CEW83_RS03765	COG0437	4 iron, 4 sulfur cluster binding
CEW83_RS03780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEW83_RS03810	COG0840	transmembrane signaling receptor activity
CEW83_RS03820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CEW83_RS03860	COG1024	Enoyl-CoA hydratase
CEW83_RS03865	COG1960	acyl-CoA dehydrogenase activity
CEW83_RS03870	COG1960	acyl-CoA dehydrogenase activity
CEW83_RS03885	COG1024	Enoyl-CoA hydratase
CEW83_RS03890	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW83_RS03900	COG0516	GMP reductase activity
CEW83_RS03920	COG0590	tRNA wobble adenosine to inosine editing
CEW83_RS03925	COG1376	ErfK ybiS ycfS ynhG family protein
CEW83_RS03930	COG2153	protein acetylation
CEW83_RS03945	COG0354	folic acid binding
CEW83_RS03950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CEW83_RS03955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CEW83_RS03970	COG0084	hydrolase, TatD family'
CEW83_RS03980	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CEW83_RS03990	COG0123	including yeast histone deacetylase and acetoin utilization protein
CEW83_RS04000	COG2307	Protein conserved in bacteria
CEW83_RS04000	COG2308	Evidence 4 Homologs of previously reported genes of
CEW83_RS04010	COG1473	amidohydrolase
CEW83_RS04015	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CEW83_RS04025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CEW83_RS04035	COG1067	ATP-dependent peptidase activity
CEW83_RS04065	COG0556	nucleotide-excision repair
CEW83_RS04070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEW83_RS04075	COG1530	ribonuclease E activity
CEW83_RS04085	COG0564	pseudouridine synthase activity
CEW83_RS04090	COG0546	phosphoglycolate phosphatase activity
CEW83_RS04100	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CEW83_RS04105	COG0424	maF-like protein
CEW83_RS04110	COG1399	metal-binding, possibly nucleic acid-binding protein
CEW83_RS04115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CEW83_RS04120	COG0416	fatty acid biosynthetic process
CEW83_RS04125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CEW83_RS04140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CEW83_RS04145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CEW83_RS04155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CEW83_RS04180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CEW83_RS04190	COG0481	GTPase activity
CEW83_RS04195	COG0681	Belongs to the peptidase S26 family
CEW83_RS04205	COG0571	ribonuclease III activity
CEW83_RS04210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CEW83_RS04215	COG1381	Involved in DNA repair and RecF pathway recombination
CEW83_RS04220	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CEW83_RS04225	COG0736	holo-[acyl-carrier-protein] synthase activity
CEW83_RS04230	COG1472	Belongs to the glycosyl hydrolase 3 family
CEW83_RS04235	COG0322	excinuclease ABC activity
CEW83_RS04240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CEW83_RS04270	COG0484	heat shock protein binding
CEW83_RS04280	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CEW83_RS04290	COG0850	regulation of cytokinetic process
CEW83_RS04295	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CEW83_RS04300	COG1393	Belongs to the ArsC family
CEW83_RS04305	COG2183	response to ionizing radiation
CEW83_RS04315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CEW83_RS04315	COG0045	succinate-CoA ligase (ADP-forming) activity
CEW83_RS04315	COG1042	CoA-binding domain protein
CEW83_RS04320	COG2202	Pas domain
CEW83_RS04320	COG2205	protein histidine kinase activity
CEW83_RS04330	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CEW83_RS04335	COG0709	Synthesizes selenophosphate from selenide and ATP
CEW83_RS04345	COG4181	ATPase activity
CEW83_RS04350	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CEW83_RS04355	COG1562	ergosterol biosynthetic process
CEW83_RS04360	COG1562	ergosterol biosynthetic process
CEW83_RS04380	COG5002	protein histidine kinase activity
CEW83_RS04380	COG5001	Diguanylate cyclase
CEW83_RS04400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW83_RS04405	COG0564	pseudouridine synthase activity
CEW83_RS04415	COG0583	DNA-binding transcription factor activity
CEW83_RS04425	COG1573	uracil-dna glycosylase
CEW83_RS04455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEW83_RS04465	COG2917	probably involved in intracellular septation
CEW83_RS04470	COG2350	Protein conserved in bacteria
CEW83_RS04475	COG0271	Belongs to the BolA IbaG family
CEW83_RS04480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEW83_RS04485	COG1960	acyl-CoA dehydrogenase activity
CEW83_RS04505	COG1309	transcriptional regulator
CEW83_RS04510	COG0084	hydrolase, TatD family'
CEW83_RS04515	COG1024	Enoyl-CoA hydratase
CEW83_RS04520	COG0318	PFAM AMP-dependent synthetase and ligase
CEW83_RS04535	COG1127	ABC transporter
CEW83_RS04540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CEW83_RS04545	COG0248	Ppx GppA phosphatase
CEW83_RS04555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CEW83_RS04590	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CEW83_RS04595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CEW83_RS04605	COG1355	regulation of microtubule-based process
CEW83_RS04610	COG3885	ferrous iron binding
CEW83_RS04610	COG2078	PFAM AMMECR1 domain protein
CEW83_RS04630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CEW83_RS04635	COG2205	protein histidine kinase activity
CEW83_RS04640	COG0745	RESPONSE REGULATOR receiver
CEW83_RS04645	COG2831	hemolysin activation secretion protein
CEW83_RS04665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CEW83_RS04670	COG0560	Phosphoserine phosphatase
CEW83_RS04675	COG2866	Carboxypeptidase
CEW83_RS04680	COG3022	response to hydroperoxide
CEW83_RS04690	COG0156	8-amino-7-oxononanoate synthase activity
CEW83_RS04695	COG2267	carboxylic ester hydrolase activity
CEW83_RS04700	COG2226	methyltransferase
CEW83_RS04705	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CEW83_RS04710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CEW83_RS04720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CEW83_RS04725	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEW83_RS04730	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEW83_RS04735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CEW83_RS04740	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEW83_RS04760	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CEW83_RS04765	COG0575	Belongs to the CDS family
CEW83_RS04770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CEW83_RS04775	COG0233	cytoplasmic translational termination
CEW83_RS04780	COG0528	UMP kinase activity
CEW83_RS04785	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CEW83_RS04790	COG0052	Belongs to the universal ribosomal protein uS2 family
CEW83_RS04800	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CEW83_RS04805	COG2862	Uncharacterized protein family, UPF0114
CEW83_RS04825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CEW83_RS04835	COG1196	nuclear chromosome segregation
CEW83_RS04840	COG0436	Aminotransferase
CEW83_RS04845	COG2171	N-acyltransferase activity
CEW83_RS04855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEW83_RS04865	COG0784	Response regulator, receiver
CEW83_RS04875	COG0633	Ferredoxin
CEW83_RS04880	COG0443	Heat shock 70 kDa protein
CEW83_RS04885	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CEW83_RS04895	COG0822	iron-sulfur transferase activity
CEW83_RS04900	COG1104	cysteine desulfurase activity
CEW83_RS04905	COG1104	cysteine desulfurase activity
CEW83_RS04915	COG1045	serine acetyltransferase
CEW83_RS04925	COG0483	inositol monophosphate 1-phosphatase activity
CEW83_RS05000	COG2326	polyphosphate kinase activity
CEW83_RS05030	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CEW83_RS05035	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CEW83_RS05040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CEW83_RS05050	COG0356	it plays a direct role in the translocation of protons across the membrane
CEW83_RS05070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CEW83_RS05085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CEW83_RS05090	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CEW83_RS05135	COG0519	Catalyzes the synthesis of GMP from XMP
CEW83_RS05135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CEW83_RS05150	COG2914	Belongs to the UPF0125 (RnfH) family
CEW83_RS05160	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CEW83_RS05165	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CEW83_RS05170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW83_RS05175	COG0601	transmembrane transport
CEW83_RS05185	COG3781	membrane
CEW83_RS05195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEW83_RS05200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEW83_RS05205	COG0509	glycine decarboxylation via glycine cleavage system
CEW83_RS05210	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CEW83_RS05210	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CEW83_RS05225	COG1215	transferase activity, transferring glycosyl groups
CEW83_RS05235	COG0583	DNA-binding transcription factor activity
CEW83_RS05245	COG1858	cytochrome C peroxidase
CEW83_RS05255	COG0386	Belongs to the glutathione peroxidase family
CEW83_RS05265	COG0488	(ABC) transporter
CEW83_RS05270	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CEW83_RS05285	COG0243	molybdopterin cofactor binding
CEW83_RS05320	COG2815	serine threonine protein kinase
CEW83_RS05320	COG0515	serine threonine protein kinase
CEW83_RS05335	COG1136	(ABC) transporter
CEW83_RS05345	COG1032	radical SAM domain protein
CEW83_RS05360	COG0537	adenosine 5'-monophosphoramidase activity
CEW83_RS05390	COG1196	nuclear chromosome segregation
CEW83_RS05415	COG1522	sequence-specific DNA binding
CEW83_RS05430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW83_RS05440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW83_RS05490	COG1280	lysine exporter protein (LysE YggA)
CEW83_RS05505	COG4106	trans-aconitate 2-methyltransferase activity
CEW83_RS05510	COG0318	PFAM AMP-dependent synthetase and ligase
CEW83_RS05550	COG0454	-acetyltransferase
CEW83_RS05580	COG1794	racemase activity, acting on amino acids and derivatives
CEW83_RS05590	COG1522	sequence-specific DNA binding
CEW83_RS05605	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CEW83_RS05610	COG1309	transcriptional regulator
CEW83_RS05615	COG1744	ABC transporter substrate-binding protein PnrA-like
CEW83_RS05620	COG3845	ABC transporter
CEW83_RS05630	COG1079	Belongs to the binding-protein-dependent transport system permease family
CEW83_RS05635	COG0402	S-adenosylhomocysteine deaminase activity
CEW83_RS05640	COG1448	Aminotransferase
CEW83_RS05685	COG0625	glutathione transferase activity
CEW83_RS05695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CEW83_RS05735	COG1490	D-aminoacyl-tRNA deacylase activity
CEW83_RS05740	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CEW83_RS05745	COG3842	ATPase activity
CEW83_RS05750	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW83_RS05755	COG1177	transmembrane transport
CEW83_RS05760	COG1115	amino acid carrier protein
CEW83_RS05790	COG5001	Diguanylate cyclase
CEW83_RS05790	COG3300	MHYT domain
CEW83_RS05795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW83_RS05795	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CEW83_RS05810	COG3447	MASE1 domain protein
CEW83_RS05810	COG5001	Diguanylate cyclase
CEW83_RS05810	COG5002	protein histidine kinase activity
CEW83_RS05815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEW83_RS05830	COG3706	GGDEF domain
CEW83_RS05870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEW83_RS05875	COG0587	DNA-directed DNA polymerase activity
CEW83_RS05885	COG0583	DNA-binding transcription factor activity
CEW83_RS05890	COG1063	alcohol dehydrogenase
CEW83_RS05910	COG0436	Aminotransferase
CEW83_RS05920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CEW83_RS05925	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CEW83_RS05930	COG0840	transmembrane signaling receptor activity
CEW83_RS05945	COG0791	NLP P60 protein
CEW83_RS05955	COG1840	ABC-type Fe3 transport system, periplasmic component
CEW83_RS05960	COG1178	ABC-type Fe3 transport system permease component
CEW83_RS05965	COG3842	ATPase activity
CEW83_RS05970	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CEW83_RS05975	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CEW83_RS05980	COG0167	dihydroorotate dehydrogenase activity
CEW83_RS05985	COG4657	Part of a membrane complex involved in electron transport
CEW83_RS05990	COG2878	Part of a membrane complex involved in electron transport
CEW83_RS05995	COG4656	Part of a membrane complex involved in electron transport
CEW83_RS06005	COG4659	FMN binding
CEW83_RS06010	COG4660	Part of a membrane complex involved in electron transport
CEW83_RS06015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CEW83_RS06035	COG0542	response to heat
CEW83_RS06050	COG0426	domain, Protein
CEW83_RS06050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CEW83_RS06055	COG1846	Transcriptional regulator
CEW83_RS06105	COG0326	Molecular chaperone. Has ATPase activity
CEW83_RS06115	COG1196	nuclear chromosome segregation
CEW83_RS06115	COG3264	Mechanosensitive ion channel
CEW83_RS06130	COG0596	Alpha beta hydrolase
CEW83_RS06145	COG1230	cation diffusion facilitator family transporter
CEW83_RS06155	COG3135	benzoate transporter
CEW83_RS06165	COG3259	Nickel-dependent hydrogenase
CEW83_RS06170	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
CEW83_RS06175	COG3383	formate dehydrogenase (NAD+) activity
CEW83_RS06180	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CEW83_RS06185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CEW83_RS06195	COG2205	protein histidine kinase activity
CEW83_RS06195	COG3850	Histidine kinase
CEW83_RS06195	COG3437	response regulator, receiver
CEW83_RS06195	COG4999	Histidine kinase
CEW83_RS06210	COG5001	Diguanylate cyclase
CEW83_RS06210	COG3300	MHYT domain
CEW83_RS06230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEW83_RS06235	COG0824	Thioesterase
CEW83_RS06255	COG4771	TonB-dependent receptor
CEW83_RS06265	COG0348	domain, Protein
CEW83_RS06290	COG1999	signal sequence binding
CEW83_RS06300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CEW83_RS06300	COG0047	phosphoribosylformylglycinamidine synthase activity
CEW83_RS06305	COG0671	phosphoesterase, PA-phosphatase related
CEW83_RS06315	COG0463	Glycosyl transferase, family 2
CEW83_RS06335	COG0739	heme binding
CEW83_RS06335	COG0741	lytic transglycosylase activity
CEW83_RS06335	COG1196	nuclear chromosome segregation
CEW83_RS06345	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CEW83_RS06355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEW83_RS06360	COG0596	Alpha beta hydrolase
CEW83_RS06365	COG2133	pyrroloquinoline quinone binding
CEW83_RS06375	COG0625	glutathione transferase activity
CEW83_RS06445	COG1518	maintenance of DNA repeat elements
CEW83_RS06455	COG3328	transposase activity
CEW83_RS06465	COG1073	alpha beta
CEW83_RS06480	COG1764	response to oxidative stress
CEW83_RS06490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CEW83_RS06505	COG1012	belongs to the aldehyde dehydrogenase family
CEW83_RS06510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEW83_RS06530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEW83_RS06535	COG0006	proline dipeptidase activity
CEW83_RS06545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CEW83_RS06550	COG5002	protein histidine kinase activity
CEW83_RS06550	COG2176	DNA-directed DNA polymerase activity
CEW83_RS06560	COG5002	protein histidine kinase activity
CEW83_RS06570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEW83_RS06585	COG2010	Cytochrome c
CEW83_RS06600	COG2814	Major facilitator Superfamily
CEW83_RS06640	COG2223	nitrite transmembrane transporter activity
CEW83_RS06650	COG0535	radical SAM domain protein
CEW83_RS06655	COG2116	formate transmembrane transporter activity
CEW83_RS06660	COG0515	serine threonine protein kinase
CEW83_RS06665	COG1279	arginine transmembrane transporter activity
CEW83_RS06675	COG0697	spore germination
CEW83_RS06705	COG5001	Diguanylate cyclase
CEW83_RS06705	COG3300	MHYT domain
CEW83_RS06740	COG1522	sequence-specific DNA binding
CEW83_RS06745	COG3391	amine dehydrogenase activity
CEW83_RS06760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CEW83_RS06760	COG1648	precorrin-2 dehydrogenase activity
CEW83_RS06765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CEW83_RS06770	COG2226	methyltransferase
CEW83_RS06795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CEW83_RS06800	COG1185	polyribonucleotide nucleotidyltransferase activity
CEW83_RS06805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CEW83_RS06810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CEW83_RS06815	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CEW83_RS06820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CEW83_RS06825	COG0195	Participates in both transcription termination and antitermination
CEW83_RS06825	COG2251	uridine kinase activity
CEW83_RS06830	COG0779	Required for maturation of 30S ribosomal subunits
CEW83_RS06840	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CEW83_RS06845	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CEW83_RS06850	COG0180	Tryptophanyl-tRNA synthetase
CEW83_RS06855	COG1994	Peptidase M50
CEW83_RS06860	COG0009	L-threonylcarbamoyladenylate synthase
CEW83_RS06865	COG0613	PHP domain protein
CEW83_RS06870	COG2267	carboxylic ester hydrolase activity
CEW83_RS06880	COG0542	response to heat
CEW83_RS06895	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CEW83_RS06900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CEW83_RS06915	COG2154	pterin-4-alpha-carbinolamine dehydratase
CEW83_RS06925	COG2081	HI0933 family
CEW83_RS06960	COG0826	peptidase U32
CEW83_RS06965	COG2900	Belongs to the SlyX family
CEW83_RS06990	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CEW83_RS06995	COG1278	Cold shock
CEW83_RS07000	COG0513	Belongs to the DEAD box helicase family
CEW83_RS07015	COG4681	YaeQ
CEW83_RS07030	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CEW83_RS07040	COG0302	gtp cyclohydrolase
CEW83_RS07050	COG0306	phosphate transporter
CEW83_RS07060	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CEW83_RS07065	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CEW83_RS07070	COG2233	PERMEase
CEW83_RS07085	COG4206	TonB-dependent receptor
CEW83_RS07090	COG2204	response regulator
CEW83_RS07110	COG2358	TRAP transporter, solute receptor (TAXI family
CEW83_RS07115	COG0579	oxidoreductase
CEW83_RS07140	COG3647	Membrane
CEW83_RS07145	COG0348	domain, Protein
CEW83_RS07150	COG1959	2 iron, 2 sulfur cluster binding
CEW83_RS07160	COG2354	Protein conserved in bacteria
CEW83_RS07175	COG0189	ligase activity
CEW83_RS07175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CEW83_RS07205	COG1741	Belongs to the pirin family
CEW83_RS07230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEW83_RS07235	COG1254	Belongs to the acylphosphatase family
CEW83_RS07245	COG0443	Heat shock 70 kDa protein
CEW83_RS07255	COG2195	Cleaves the N-terminal amino acid of tripeptides
CEW83_RS07275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CEW83_RS07290	COG2816	NAD+ diphosphatase activity
CEW83_RS07295	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CEW83_RS07310	COG0356	it plays a direct role in the translocation of protons across the membrane
CEW83_RS07320	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CEW83_RS07320	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CEW83_RS07325	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CEW83_RS07335	COG1132	(ABC) transporter
CEW83_RS07350	COG1272	protein, Hemolysin III
CEW83_RS07360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CEW83_RS07365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEW83_RS07410	COG3706	GGDEF domain
CEW83_RS07450	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CEW83_RS07455	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CEW83_RS07460	COG0740	serine-type endopeptidase activity
CEW83_RS07465	COG0544	peptidyl-prolyl cis-trans isomerase activity
CEW83_RS07470	COG2766	serine protein kinase
CEW83_RS07475	COG2718	Belongs to the UPF0229 family
CEW83_RS07480	COG2719	SpoVR family
CEW83_RS07485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CEW83_RS07485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CEW83_RS07495	COG0697	spore germination
CEW83_RS07505	COG1595	DNA-templated transcription, initiation
CEW83_RS07515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CEW83_RS07545	COG0438	transferase activity, transferring glycosyl groups
CEW83_RS07560	COG1183	phosphatidylcholine synthase activity
CEW83_RS07575	COG3360	Dodecin
CEW83_RS07595	COG1309	transcriptional regulator
CEW83_RS07610	COG1136	(ABC) transporter
CEW83_RS07620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CEW83_RS07720	COG0009	L-threonylcarbamoyladenylate synthase
CEW83_RS07725	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CEW83_RS07730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CEW83_RS07735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CEW83_RS07745	COG4566	intracellular signal transduction
CEW83_RS07760	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CEW83_RS07765	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEW83_RS07770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEW83_RS07805	COG0802	atpase or kinase
CEW83_RS07810	COG0860	N-Acetylmuramoyl-L-alanine amidase
CEW83_RS07815	COG0196	riboflavin kinase activity
CEW83_RS07820	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CEW83_RS07825	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CEW83_RS07830	COG1047	Peptidyl-prolyl cis-trans
CEW83_RS07835	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CEW83_RS07845	COG1722	exodeoxyribonuclease VII activity
CEW83_RS07850	COG0142	geranyltranstransferase activity
CEW83_RS07855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CEW83_RS07860	COG1469	GTP cyclohydrolase I activity
CEW83_RS07865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEW83_RS07875	COG0022	dehydrogenase e1 component
CEW83_RS07880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CEW83_RS07900	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CEW83_RS07905	COG3012	SEC-C Motif Domain Protein
CEW83_RS07940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CEW83_RS07950	COG0254	rRNA binding
CEW83_RS07960	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CEW83_RS07965	COG0501	Belongs to the peptidase M48B family
CEW83_RS07985	COG2308	Evidence 4 Homologs of previously reported genes of
CEW83_RS07990	COG0183	Belongs to the thiolase family
CEW83_RS08020	COG1666	GTP binding
CEW83_RS08025	COG3123	guanosine phosphorylase activity
CEW83_RS08035	COG0137	argininosuccinate synthase activity
CEW83_RS08040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CEW83_RS08045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CEW83_RS08055	COG0268	Binds directly to 16S ribosomal RNA
CEW83_RS08080	COG0563	adenylate kinase activity
CEW83_RS08085	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CEW83_RS08090	COG2835	tetraacyldisaccharide 4'-kinase activity
CEW83_RS08095	COG1663	tetraacyldisaccharide 4'-kinase activity
CEW83_RS08105	COG0811	peptide transport
CEW83_RS08110	COG1570	exodeoxyribonuclease VII activity
CEW83_RS08115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CEW83_RS08120	COG0564	pseudouridine synthase activity
CEW83_RS08130	COG0784	Response regulator, receiver
CEW83_RS08130	COG2198	Histidine kinase
CEW83_RS08130	COG0643	Histidine kinase
CEW83_RS08135	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CEW83_RS08140	COG0745	RESPONSE REGULATOR receiver
CEW83_RS08145	COG0784	Response regulator, receiver
CEW83_RS08145	COG0835	chemotaxis
CEW83_RS08150	COG0835	chemotaxis
CEW83_RS08150	COG0784	Response regulator, receiver
CEW83_RS08155	COG0840	transmembrane signaling receptor activity
CEW83_RS08160	COG2201	protein-glutamate methylesterase activity
CEW83_RS08175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CEW83_RS08220	COG3845	ABC transporter
CEW83_RS08225	COG4603	Belongs to the binding-protein-dependent transport system permease family
CEW83_RS08230	COG1079	Belongs to the binding-protein-dependent transport system permease family
CEW83_RS08240	COG0457	Tetratricopeptide repeat
CEW83_RS08280	COG3754	Rhamnan synthesis protein F
CEW83_RS08295	COG1334	flagellar protein FlaG
CEW83_RS08300	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CEW83_RS08320	COG2257	FlhB HrpN YscU SpaS Family
CEW83_RS08325	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CEW83_RS08330	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CEW83_RS08335	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CEW83_RS08345	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CEW83_RS08355	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CEW83_RS08360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEW83_RS08375	COG3181	Tripartite tricarboxylate transporter family receptor
CEW83_RS08380	COG2721	sulfolactate sulfo-lyase activity
CEW83_RS08385	COG2721	sulfolactate sulfo-lyase activity
CEW83_RS08395	COG2188	Transcriptional regulator
CEW83_RS08400	COG2855	membrane
CEW83_RS08420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW83_RS08425	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW83_RS08425	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW83_RS08435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CEW83_RS08440	COG1028	Short-chain dehydrogenase reductase Sdr
CEW83_RS08450	COG1677	Flagellar hook-basal body complex protein FliE
CEW83_RS08480	COG1157	protein secretion by the type III secretion system
CEW83_RS08490	COG0402	S-adenosylhomocysteine deaminase activity
CEW83_RS08505	COG0662	Cupin 2, conserved barrel domain protein
CEW83_RS08505	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CEW83_RS08510	COG0175	sulfate reduction
CEW83_RS08525	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CEW83_RS08545	COG0583	DNA-binding transcription factor activity
CEW83_RS08565	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CEW83_RS08585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CEW83_RS08590	COG1028	Short-chain dehydrogenase reductase Sdr
CEW83_RS08600	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CEW83_RS08610	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CEW83_RS08610	COG0662	Cupin 2, conserved barrel domain protein
CEW83_RS08635	COG0438	transferase activity, transferring glycosyl groups
CEW83_RS08655	COG0489	protein tyrosine kinase activity
CEW83_RS08685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CEW83_RS08690	COG3852	Histidine kinase
CEW83_RS08720	COG3273	potassium ion transport
CEW83_RS08720	COG0471	metal ion transport
CEW83_RS08750	COG2204	response regulator
CEW83_RS08770	COG3383	formate dehydrogenase (NAD+) activity
CEW83_RS08850	COG0793	Belongs to the peptidase S41A family
CEW83_RS08885	COG0720	synthase
CEW83_RS08895	COG1511	domain protein
CEW83_RS08895	COG3264	Mechanosensitive ion channel
CEW83_RS08900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEW83_RS08905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CEW83_RS08905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEW83_RS08915	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CEW83_RS08925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CEW83_RS08930	COG1238	metal cluster binding
CEW83_RS08940	COG5001	Diguanylate cyclase
CEW83_RS08940	COG3300	MHYT domain
CEW83_RS08950	COG1793	dna ligase
CEW83_RS08955	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CEW83_RS08985	COG0028	Belongs to the TPP enzyme family
CEW83_RS08990	COG0440	acetolactate synthase activity
CEW83_RS08995	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CEW83_RS09015	COG2205	protein histidine kinase activity
CEW83_RS09020	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CEW83_RS09025	COG1183	phosphatidylcholine synthase activity
CEW83_RS09040	COG0642	Histidine kinase
CEW83_RS09050	COG3642	lipopolysaccharide core region biosynthetic process
CEW83_RS09075	COG1858	cytochrome C peroxidase
CEW83_RS09085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CEW83_RS09090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEW83_RS09105	COG1295	ribonuclease BN
CEW83_RS09115	COG0228	four-way junction DNA binding
CEW83_RS09120	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CEW83_RS09125	COG0336	Belongs to the RNA methyltransferase TrmD family
CEW83_RS09130	COG0335	large ribosomal subunit rRNA binding
CEW83_RS09140	COG0795	lipopolysaccharide-transporting ATPase activity
CEW83_RS09145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CEW83_RS09160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW83_RS09170	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CEW83_RS09175	COG0583	DNA-binding transcription factor activity
CEW83_RS09180	COG0525	valine-tRNA ligase activity
CEW83_RS09185	COG0425	Belongs to the sulfur carrier protein TusA family
CEW83_RS09195	COG0315	cyclic pyranopterin monophosphate synthase activity
CEW83_RS09210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CEW83_RS09230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEW83_RS09235	COG2414	aldehyde ferredoxin oxidoreductase
CEW83_RS09245	COG3284	Transcriptional regulator
CEW83_RS09270	COG1012	belongs to the aldehyde dehydrogenase family
CEW83_RS09275	COG3284	Transcriptional regulator
CEW83_RS09295	COG0784	Response regulator, receiver
CEW83_RS09295	COG4191	Histidine kinase
CEW83_RS09300	COG0318	PFAM AMP-dependent synthetase and ligase
CEW83_RS09305	COG1960	acyl-CoA dehydrogenase activity
CEW83_RS09315	COG0659	secondary active sulfate transmembrane transporter activity
CEW83_RS09325	COG1054	Belongs to the UPF0176 family
CEW83_RS09335	COG4172	Belongs to the ABC transporter superfamily
CEW83_RS09340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW83_RS09345	COG0601	transmembrane transport
CEW83_RS09350	COG0747	negative chemotaxis
CEW83_RS09360	COG0583	DNA-binding transcription factor activity
CEW83_RS09380	COG3264	Mechanosensitive ion channel
CEW83_RS09380	COG1511	domain protein
CEW83_RS09415	COG1131	(ABC) transporter
CEW83_RS09485	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEW83_RS09495	COG0583	DNA-binding transcription factor activity
CEW83_RS09520	COG0247	lactate metabolic process
CEW83_RS09545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW83_RS09605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW83_RS09615	COG1454	alcohol dehydrogenase
CEW83_RS09630	COG4772	TonB-dependent receptor
CEW83_RS09645	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW83_RS09655	COG1012	belongs to the aldehyde dehydrogenase family
CEW83_RS09660	COG0693	protein deglycase activity
CEW83_RS09670	COG0644	oxidoreductase
CEW83_RS09670	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CEW83_RS09675	COG0837	glucose binding
CEW83_RS09680	COG0166	Belongs to the GPI family
CEW83_RS09695	COG0142	geranyltranstransferase activity
CEW83_RS09700	COG0584	glycerophosphoryl diester phosphodiesterase
CEW83_RS09715	COG0667	Aldo Keto reductase
CEW83_RS09720	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CEW83_RS09725	COG0513	Belongs to the DEAD box helicase family
CEW83_RS09735	COG1428	Deoxynucleoside kinase
CEW83_RS09740	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CEW83_RS09745	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CEW83_RS09750	COG0516	GMP reductase activity
CEW83_RS09750	COG0517	IMP dehydrogenase activity
CEW83_RS09755	COG0308	aminopeptidase N
CEW83_RS09785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CEW83_RS09795	COG0589	response to stress
CEW83_RS09800	COG0538	isocitrate dehydrogenase activity
CEW83_RS09805	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CEW83_RS09835	COG4654	Cytochrome c, class I
CEW83_RS09840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CEW83_RS09845	COG0640	Transcriptional regulator
CEW83_RS09855	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEW83_RS09870	COG0756	dUTP diphosphatase activity
CEW83_RS09875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CEW83_RS09880	COG2003	Belongs to the UPF0758 family
CEW83_RS09885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CEW83_RS09890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CEW83_RS09895	COG1278	Cold shock
CEW83_RS09900	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CEW83_RS09905	COG0542	response to heat
CEW83_RS09910	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CEW83_RS09915	COG2224	Isocitrate lyase
CEW83_RS09930	COG2205	protein histidine kinase activity
CEW83_RS09935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CEW83_RS09940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CEW83_RS09960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CEW83_RS09965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CEW83_RS09970	COG0739	heme binding
CEW83_RS09975	COG0316	Belongs to the HesB IscA family
CEW83_RS09980	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CEW83_RS09985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CEW83_RS09995	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CEW83_RS10005	COG0494	nUDIX hydrolase
CEW83_RS10010	COG0442	prolyl-tRNA aminoacylation
CEW83_RS10015	COG0741	lytic transglycosylase activity
CEW83_RS10025	COG2204	response regulator
CEW83_RS10030	COG0312	modulator of DNA gyrase
CEW83_RS10035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW83_RS10045	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CEW83_RS10050	COG5607	PFAM CHAD domain containing protein
CEW83_RS10050	COG3025	triphosphatase activity
CEW83_RS10070	COG0482	sulfurtransferase activity
CEW83_RS10100	COG0429	hydrolase of the alpha beta-hydrolase fold
CEW83_RS10110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CEW83_RS10115	COG2096	Adenosyltransferase
CEW83_RS10120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CEW83_RS10130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CEW83_RS10135	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CEW83_RS10140	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CEW83_RS10145	COG0521	Mo-molybdopterin cofactor biosynthetic process
CEW83_RS10150	COG3028	Belongs to the UPF0307 family
CEW83_RS10155	COG0312	modulator of DNA gyrase
CEW83_RS10165	COG2951	lytic endotransglycosylase activity
CEW83_RS10180	COG1346	cytolysis
CEW83_RS10190	COG5002	protein histidine kinase activity
CEW83_RS10195	COG0745	RESPONSE REGULATOR receiver
CEW83_RS10205	COG4251	negative regulation of phosphorylation
CEW83_RS10215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEW83_RS10220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW83_RS10225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CEW83_RS10230	COG0628	permease
CEW83_RS10235	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CEW83_RS10245	COG0617	tRNA 3'-terminal CCA addition
CEW83_RS10270	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CEW83_RS10285	COG0247	lactate metabolic process
CEW83_RS10290	COG0277	FAD linked oxidase domain protein
CEW83_RS10295	COG0277	FAD linked oxidase domain protein
CEW83_RS10310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CEW83_RS10315	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CEW83_RS10320	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CEW83_RS10325	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CEW83_RS10340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CEW83_RS10340	COG3320	Male sterility
CEW83_RS10355	COG4591	ABC-type transport system involved in lipoprotein release permease component
CEW83_RS10370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEW83_RS10380	COG0604	alcohol dehydrogenase
CEW83_RS10390	COG1704	LemA family
CEW83_RS10400	COG0488	(ABC) transporter
CEW83_RS10420	COG0741	lytic transglycosylase activity
CEW83_RS10420	COG0739	heme binding
CEW83_RS10420	COG1196	nuclear chromosome segregation
CEW83_RS10435	COG2204	response regulator
CEW83_RS10440	COG4191	Histidine kinase
CEW83_RS10445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CEW83_RS10450	COG2030	dehydratase
CEW83_RS10465	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CEW83_RS10485	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CEW83_RS10520	COG0633	Ferredoxin
CEW83_RS10525	COG0426	domain, Protein
CEW83_RS10535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CEW83_RS10560	COG4657	Part of a membrane complex involved in electron transport
CEW83_RS10565	COG2878	Part of a membrane complex involved in electron transport
CEW83_RS10570	COG4656	Part of a membrane complex involved in electron transport
CEW83_RS10580	COG4659	FMN binding
CEW83_RS10590	COG2914	Belongs to the UPF0125 (RnfH) family
CEW83_RS10620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CEW83_RS10630	COG4536	flavin adenine dinucleotide binding
CEW83_RS10645	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CEW83_RS10660	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CEW83_RS10675	COG0733	neurotransmitter:sodium symporter activity
CEW83_RS10680	COG1522	sequence-specific DNA binding
CEW83_RS10690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEW83_RS10700	COG0134	indole-3-glycerol-phosphate synthase activity
CEW83_RS10705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CEW83_RS10720	COG0546	phosphoglycolate phosphatase activity
CEW83_RS10725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CEW83_RS10730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CEW83_RS10735	COG5212	phosphodiesterase
CEW83_RS10750	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CEW83_RS10755	COG0045	succinate-CoA ligase (ADP-forming) activity
CEW83_RS10770	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CEW83_RS10780	COG0805	protein transport
CEW83_RS10785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CEW83_RS10790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CEW83_RS10800	COG0140	phosphoribosyl-ATP diphosphatase activity
CEW83_RS10805	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CEW83_RS10810	COG0107	imidazoleglycerol-phosphate synthase activity
CEW83_RS10815	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CEW83_RS10820	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CEW83_RS10825	COG0131	Imidazoleglycerol-phosphate dehydratase
CEW83_RS10830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CEW83_RS10835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CEW83_RS10840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CEW83_RS10845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CEW83_RS10850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CEW83_RS10860	COG0842	Transport permease protein
CEW83_RS10865	COG1131	(ABC) transporter
CEW83_RS10885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CEW83_RS10890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CEW83_RS10895	COG1127	ABC transporter
CEW83_RS10960	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CEW83_RS10965	COG1024	Enoyl-CoA hydratase
CEW83_RS10980	COG0204	Acyl-transferase
CEW83_RS10985	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CEW83_RS10990	COG0751	glycine-tRNA ligase activity
CEW83_RS10995	COG0752	glycyl-tRNA synthetase alpha subunit
CEW83_RS11000	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CEW83_RS11005	COG4535	Mg2 and Co2 transporter CorC
CEW83_RS11010	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CEW83_RS11015	COG1702	phosphate starvation-inducible protein PhoH
CEW83_RS11020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CEW83_RS11035	COG1739	Uncharacterized protein family UPF0029
CEW83_RS11060	COG2308	Evidence 4 Homologs of previously reported genes of
CEW83_RS11065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEW83_RS11090	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CEW83_RS11095	COG1607	acyl-coa hydrolase
CEW83_RS11100	COG3634	alkyl hydroperoxide reductase activity
CEW83_RS11115	COG2177	Part of the ABC transporter FtsEX involved in
CEW83_RS11120	COG2884	Cell division ATP-binding protein ftsE
CEW83_RS11130	COG0612	Peptidase, M16
CEW83_RS11135	COG0612	Peptidase, M16
CEW83_RS11140	COG0742	ribosomal rna small subunit methyltransferase
CEW83_RS11145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CEW83_RS11150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CEW83_RS11155	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CEW83_RS11160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CEW83_RS11170	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CEW83_RS11175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CEW83_RS11185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CEW83_RS11190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CEW83_RS11195	COG0193	aminoacyl-tRNA hydrolase activity
CEW83_RS11200	COG0012	GTP binding
CEW83_RS11205	COG3002	Belongs to the UPF0753 family
CEW83_RS11210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CEW83_RS11220	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CEW83_RS11225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CEW83_RS11225	COG2169	Transcriptional regulator
CEW83_RS11240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CEW83_RS11245	COG1053	succinate dehydrogenase
CEW83_RS11265	COG4263	nitrous-oxide reductase activity
CEW83_RS11290	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CEW83_RS11320	COG0456	acetyltransferase
CEW83_RS11320	COG0454	-acetyltransferase
CEW83_RS11335	COG0488	(ABC) transporter
CEW83_RS11340	COG1115	amino acid carrier protein
CEW83_RS11345	COG0583	DNA-binding transcription factor activity
CEW83_RS11350	COG0477	Major facilitator Superfamily
CEW83_RS11390	COG1595	DNA-templated transcription, initiation
CEW83_RS11400	COG1944	ATP diphosphatase activity
CEW83_RS11440	COG3459	Glycosyltransferase 36 associated
CEW83_RS11455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEW83_RS11460	COG0798	PFAM Bile acid sodium symporter
CEW83_RS11475	COG0583	DNA-binding transcription factor activity
CEW83_RS11480	COG1741	Belongs to the pirin family
CEW83_RS11500	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CEW83_RS11505	COG3842	ATPase activity
CEW83_RS11510	COG1177	transmembrane transport
CEW83_RS11515	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW83_RS11525	COG1349	DNA-binding transcription factor activity
CEW83_RS11530	COG2267	carboxylic ester hydrolase activity
CEW83_RS11535	COG0697	spore germination
CEW83_RS11575	COG0463	Glycosyl transferase, family 2
CEW83_RS11620	COG0436	Aminotransferase
CEW83_RS11625	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CEW83_RS11640	COG2084	Dehydrogenase
CEW83_RS11645	COG2084	Dehydrogenase
CEW83_RS11650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CEW83_RS11660	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CEW83_RS11670	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CEW83_RS11700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CEW83_RS11710	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CEW83_RS11720	COG0784	Response regulator, receiver
CEW83_RS11725	COG4251	negative regulation of phosphorylation
CEW83_RS11735	COG0629	single-stranded DNA binding
CEW83_RS11740	COG2814	Major facilitator Superfamily
CEW83_RS11755	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CEW83_RS11760	COG0203	ribosomal protein L17
CEW83_RS11765	COG0202	RNA polymerase activity
CEW83_RS11770	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CEW83_RS11775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CEW83_RS11780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CEW83_RS11785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CEW83_RS11790	COG0201	protein transport
CEW83_RS11795	COG0200	Binds to the 23S rRNA
CEW83_RS11800	COG1841	ribosomal large subunit assembly
CEW83_RS11805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CEW83_RS11810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CEW83_RS11815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CEW83_RS11820	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CEW83_RS11825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CEW83_RS11830	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CEW83_RS11835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CEW83_RS11840	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CEW83_RS11845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CEW83_RS11850	COG0255	Belongs to the universal ribosomal protein uL29 family
CEW83_RS11855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CEW83_RS11860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CEW83_RS11865	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CEW83_RS11870	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CEW83_RS11875	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CEW83_RS11880	COG0089	rRNA binding
CEW83_RS11885	COG0088	Forms part of the polypeptide exit tunnel
CEW83_RS11890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CEW83_RS11895	COG0051	transcription antitermination factor activity, RNA binding
CEW83_RS11900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CEW83_RS11905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CEW83_RS11910	COG0049	tRNA binding
CEW83_RS11915	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CEW83_RS11920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CEW83_RS11925	COG0085	RNA polymerase activity
CEW83_RS11930	COG0222	ribosome binding
CEW83_RS11935	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CEW83_RS11940	COG0081	regulation of translation
CEW83_RS11945	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CEW83_RS11955	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CEW83_RS11965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CEW83_RS11990	COG5265	(ABC) transporter
CEW83_RS12015	COG0252	asparaginase activity
CEW83_RS12020	COG0583	DNA-binding transcription factor activity
CEW83_RS12025	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEW83_RS12035	COG0175	sulfate reduction
CEW83_RS12040	COG0175	sulfate reduction
CEW83_RS12045	COG2895	sulfate adenylyltransferase (ATP) activity
CEW83_RS12060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CEW83_RS12070	COG0501	Belongs to the peptidase M48B family
CEW83_RS12075	COG0513	Belongs to the DEAD box helicase family
CEW83_RS12080	COG0778	Nitroreductase
CEW83_RS12105	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CEW83_RS12140	COG0427	acetyl-CoA hydrolase
CEW83_RS12190	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CEW83_RS12195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CEW83_RS12200	COG1538	Outer membrane efflux protein
CEW83_RS12225	COG2818	Glycosylase
CEW83_RS12235	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CEW83_RS12245	COG2070	2-Nitropropane dioxygenase
CEW83_RS12275	COG1764	response to oxidative stress
CEW83_RS12295	COG0583	DNA-binding transcription factor activity
CEW83_RS12370	COG0628	permease
CEW83_RS12375	COG2823	Periplasmic or secreted lipoprotein
CEW83_RS12385	COG5487	UPF0391 membrane protein
CEW83_RS12415	COG0789	Transcriptional regulator
CEW83_RS12440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CEW83_RS12450	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CEW83_RS12465	COG0067	glutamate synthase
CEW83_RS12465	COG0070	glutamate synthase
CEW83_RS12465	COG0069	glutamate synthase activity
CEW83_RS12470	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CEW83_RS12475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CEW83_RS12480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CEW83_RS12515	COG1965	Belongs to the frataxin family
CEW83_RS12545	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CEW83_RS12550	COG0284	orotidine-5'-phosphate decarboxylase activity
CEW83_RS12555	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CEW83_RS12560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CEW83_RS12570	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CEW83_RS12615	COG1805	sodium ion transport
CEW83_RS12625	COG0183	Belongs to the thiolase family
CEW83_RS12630	COG1024	Enoyl-CoA hydratase
CEW83_RS12630	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW83_RS12635	COG2067	long-chain fatty acid transport protein
CEW83_RS12645	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW83_RS12645	COG1024	Enoyl-CoA hydratase
CEW83_RS12655	COG1960	acyl-CoA dehydrogenase activity
CEW83_RS12680	COG0523	cobalamin synthesis protein
CEW83_RS12685	COG0277	FAD linked oxidase domain protein
CEW83_RS12705	COG2197	response regulator
CEW83_RS12725	COG2198	Histidine kinase
CEW83_RS12725	COG2205	protein histidine kinase activity
CEW83_RS12725	COG0784	Response regulator, receiver
CEW83_RS12735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CEW83_RS12770	COG1022	Amp-dependent synthetase and ligase
CEW83_RS12775	COG1703	isobutyryl-CoA mutase activity
CEW83_RS12775	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CEW83_RS12775	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CEW83_RS12785	COG4191	Histidine kinase
CEW83_RS12785	COG0784	Response regulator, receiver
CEW83_RS12800	COG2321	neutral zinc metallopeptidase
CEW83_RS12815	COG4770	biotin carboxylase activity
CEW83_RS12820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CEW83_RS12825	COG1703	isobutyryl-CoA mutase activity
CEW83_RS12830	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CEW83_RS12830	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CEW83_RS12835	COG1802	Transcriptional regulator
CEW83_RS12840	COG1253	flavin adenine dinucleotide binding
CEW83_RS12845	COG0114	fumarate hydratase activity
CEW83_RS12850	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CEW83_RS12855	COG3162	membrane
CEW83_RS12860	COG1024	Enoyl-CoA hydratase
CEW83_RS12865	COG1492	cobalamin metabolic process
CEW83_RS12900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEW83_RS12905	COG1999	signal sequence binding
CEW83_RS12910	COG0109	protoheme IX farnesyltransferase activity
CEW83_RS12945	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CEW83_RS12950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CEW83_RS12965	COG0300	oxidoreductase activity
CEW83_RS12985	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CEW83_RS13000	COG1469	GTP cyclohydrolase I activity
CEW83_RS13030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEW83_RS13035	COG1832	CoA-binding protein
CEW83_RS13040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEW83_RS13045	COG3568	Endonuclease Exonuclease Phosphatase
CEW83_RS13050	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CEW83_RS13065	COG0174	glutamine synthetase
CEW83_RS13075	COG3852	Histidine kinase
CEW83_RS13090	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CEW83_RS13100	COG0237	dephospho-CoA kinase activity
CEW83_RS13105	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CEW83_RS13110	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CEW83_RS13115	COG0494	nUDIX hydrolase
CEW83_RS13125	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CEW83_RS13130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CEW83_RS13135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEW83_RS13165	COG0305	Participates in initiation and elongation during chromosome replication
CEW83_RS13170	COG0359	binds to the 23S rRNA
CEW83_RS13175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CEW83_RS13180	COG2965	DNA replication, synthesis of RNA primer
CEW83_RS13185	COG0360	Binds together with S18 to 16S ribosomal RNA
CEW83_RS13195	COG1643	Atp-dependent helicase
CEW83_RS13215	COG1968	undecaprenyl-diphosphatase activity
CEW83_RS13220	COG3150	esterase
CEW83_RS13225	COG2226	methyltransferase
CEW83_RS13230	COG2962	Rard protein
CEW83_RS13235	COG0557	exoribonuclease II activity
CEW83_RS13245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CEW83_RS13250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CEW83_RS13255	COG2239	Acts as a magnesium transporter
CEW83_RS13260	COG2119	membrane
CEW83_RS13265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CEW83_RS13270	COG0352	thiamine-phosphate diphosphorylase activity
CEW83_RS13280	COG1773	rubredoxin
CEW83_RS13300	COG0840	transmembrane signaling receptor activity
CEW83_RS13305	COG0643	Histidine kinase
CEW83_RS13305	COG2198	Histidine kinase
CEW83_RS13310	COG0415	Belongs to the DNA photolyase family
CEW83_RS13315	COG1678	Uncharacterized ACR, COG1678
CEW83_RS13320	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CEW83_RS13325	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CEW83_RS13330	COG0540	Belongs to the ATCase OTCase family
CEW83_RS13340	COG1872	DUF167
CEW83_RS13345	COG0762	integral membrane protein
CEW83_RS13390	COG0437	4 iron, 4 sulfur cluster binding
CEW83_RS13430	COG0746	molybdenum cofactor guanylyltransferase activity
CEW83_RS13440	COG1763	Mo-molybdopterin cofactor biosynthetic process
CEW83_RS13445	COG4191	Histidine kinase
CEW83_RS13455	COG1981	membrane
CEW83_RS13470	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CEW83_RS13475	COG3852	Histidine kinase
CEW83_RS13485	COG4654	Cytochrome c, class I
CEW83_RS13500	COG4302	ethanolamine ammonia-lyase activity
CEW83_RS13510	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CEW83_RS13515	COG0830	nickel cation binding
CEW83_RS13520	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CEW83_RS13525	COG0804	urea catabolic process
CEW83_RS13530	COG0832	Belongs to the urease beta subunit family
CEW83_RS13540	COG0831	urea catabolic process
CEW83_RS13545	COG0829	nickel cation binding
CEW83_RS13550	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CEW83_RS13550	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CEW83_RS13555	COG0659	secondary active sulfate transmembrane transporter activity
CEW83_RS13600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW83_RS13605	COG1116	anion transmembrane transporter activity
CEW83_RS13610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW83_RS13615	COG0583	DNA-binding transcription factor activity
CEW83_RS13655	COG3047	cAMP biosynthetic process
CEW83_RS13660	COG0513	Belongs to the DEAD box helicase family
CEW83_RS13670	COG1451	nucleotide metabolic process
CEW83_RS13675	COG1132	(ABC) transporter
CEW83_RS13680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEW83_RS13690	COG5002	protein histidine kinase activity
CEW83_RS13690	COG2198	Histidine kinase
CEW83_RS13690	COG0784	Response regulator, receiver
CEW83_RS13695	COG1538	Outer membrane efflux protein
CEW83_RS13705	COG2203	Gaf domain
CEW83_RS13705	COG2199	diguanylate cyclase activity
CEW83_RS13705	COG2200	EAL domain
CEW83_RS13720	COG2197	response regulator
CEW83_RS13725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW83_RS13730	COG2274	protein secretion by the type I secretion system
CEW83_RS13750	COG1136	(ABC) transporter
CEW83_RS13760	COG0735	belongs to the Fur family
CEW83_RS13765	COG1121	(ABC) transporter
CEW83_RS13775	COG0803	Belongs to the bacterial solute-binding protein 9 family
CEW83_RS13780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CEW83_RS13785	COG1074	ATP-dependent DNA helicase activity
CEW83_RS13790	COG0688	phosphatidylethanolamine metabolic process
CEW83_RS13795	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CEW83_RS13800	COG3530	Putative quorum-sensing-regulated virulence factor
CEW83_RS13805	COG2095	MarC family integral membrane protein
CEW83_RS13815	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CEW83_RS13825	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CEW83_RS13840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEW83_RS13845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW83_RS13855	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CEW83_RS13875	COG0419	ATPase involved in DNA repair
CEW83_RS13880	COG0420	3'-5' exonuclease activity
CEW83_RS13895	COG1028	Short-chain dehydrogenase reductase Sdr
CEW83_RS13905	COG0432	Pfam Uncharacterised protein family UPF0047
CEW83_RS13920	COG0616	signal peptide processing
CEW83_RS13925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CEW83_RS13930	COG2022	thiamine diphosphate biosynthetic process
CEW83_RS13940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CEW83_RS13950	COG1126	abc transporter atp-binding protein
CEW83_RS13955	COG0765	amino acid transport
CEW83_RS13960	COG4597	amino acid ABC transporter
CEW83_RS13965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEW83_RS13980	COG2814	Major facilitator Superfamily
CEW83_RS14000	COG0288	reversible hydration of carbon dioxide
CEW83_RS14005	COG1940	carbohydrate kinase activity
CEW83_RS14010	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CEW83_RS14015	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CEW83_RS14025	COG0569	domain protein
CEW83_RS14030	COG2204	response regulator
CEW83_RS14035	COG5000	phosphorelay sensor kinase activity
CEW83_RS14065	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CEW83_RS14070	COG0706	membrane insertase activity
CEW83_RS14075	COG0594	ribonuclease P activity
CEW83_RS14080	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CEW83_RS14085	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CEW83_RS14125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CEW83_RS14220	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CEW83_RS14250	COG3586	endonuclease activity
CEW83_RS14255	COG3311	Transcriptional regulator
CEW83_RS14260	COG1569	PIN domain
CEW83_RS14275	COG0583	DNA-binding transcription factor activity
CEW83_RS14280	COG2814	Major facilitator Superfamily
CEW83_RS14285	COG0527	aspartate kinase activity
CEW83_RS14295	COG1858	cytochrome C peroxidase
CEW83_RS14305	COG1131	(ABC) transporter
CEW83_RS14310	COG0842	Transport permease protein
CEW83_RS14325	COG0583	DNA-binding transcription factor activity
CEW83_RS14355	COG3040	lipid binding
CEW83_RS14385	COG3842	ATPase activity
CEW83_RS14395	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW83_RS14400	COG1177	transmembrane transport
CEW83_RS14415	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CEW83_RS14420	COG1984	allophanate hydrolase subunit 2
CEW83_RS14425	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CEW83_RS14450	COG0783	Belongs to the Dps family
CEW83_RS14460	COG4206	TonB-dependent receptor
CEW83_RS14465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CEW83_RS14470	COG3706	GGDEF domain
CEW83_RS14480	COG3909	cytochrome
CEW83_RS14490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CEW83_RS14500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CEW83_RS14510	COG1187	pseudouridine synthase activity
CEW83_RS14520	COG2974	May be involved in recombination
CEW83_RS14525	COG1454	alcohol dehydrogenase
CEW83_RS14540	COG1454	alcohol dehydrogenase
CEW83_RS14545	COG0410	ABC transporter
CEW83_RS14550	COG1137	ATPase activity
CEW83_RS14560	COG0559	Belongs to the binding-protein-dependent transport system permease family
CEW83_RS14575	COG2204	response regulator
CEW83_RS14580	COG3852	Histidine kinase
CEW83_RS14590	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CEW83_RS14600	COG2922	Belongs to the Smg family
CEW83_RS14605	COG0758	DNA mediated transformation
CEW83_RS14615	COG0242	peptide deformylase activity
CEW83_RS14620	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CEW83_RS14625	COG0501	Belongs to the peptidase M48B family
CEW83_RS14630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEW83_RS14635	COG1305	Transglutaminase-like
CEW83_RS14645	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CEW83_RS14650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEW83_RS14660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CEW83_RS14680	COG0583	DNA-binding transcription factor activity
CEW83_RS14685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CEW83_RS14695	COG0583	DNA-binding transcription factor activity
CEW83_RS14730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEW83_RS14735	COG0431	NADPH-dependent FMN reductase
CEW83_RS14740	COG1393	Belongs to the ArsC family
CEW83_RS14780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW83_RS14785	COG0577	efflux transmembrane transporter activity
CEW83_RS14785	COG1136	(ABC) transporter
CEW83_RS14790	COG1136	(ABC) transporter
CEW83_RS14790	COG0577	efflux transmembrane transporter activity
CEW83_RS14805	COG1278	Cold shock
CEW83_RS14810	COG0535	radical SAM domain protein
CEW83_RS14820	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CEW83_RS14825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CEW83_RS14845	COG0583	DNA-binding transcription factor activity
CEW83_RS14870	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CEW83_RS14920	COG3608	succinylglutamate desuccinylase aspartoacylase
CEW83_RS14920	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CEW83_RS14950	COG3217	Mosc domain protein beta barrel domain protein
CEW83_RS14950	COG0633	Ferredoxin
CEW83_RS14955	COG3706	GGDEF domain
CEW83_RS14965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEW83_RS14990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW83_RS14995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW83_RS15000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW83_RS15000	COG1116	anion transmembrane transporter activity
CEW83_RS15005	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CEW83_RS15030	COG2249	NAD(P)H dehydrogenase (quinone) activity
CEW83_RS15040	COG0697	spore germination
CEW83_RS15045	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW83_RS15050	COG2205	protein histidine kinase activity
CEW83_RS15050	COG0784	Response regulator, receiver
CEW83_RS15050	COG5002	protein histidine kinase activity
CEW83_RS15055	COG3437	response regulator, receiver
CEW83_RS15060	COG0445	tRNA wobble uridine modification
CEW83_RS15065	COG0357	Ribosomal RNA small subunit methyltransferase G
CEW83_RS15070	COG1192	Involved in chromosome partitioning
CEW83_RS15075	COG1475	DNA binding
CEW83_RS15095	COG0356	it plays a direct role in the translocation of protons across the membrane
CEW83_RS15105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CEW83_RS15110	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CEW83_RS15115	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CEW83_RS15120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CEW83_RS15125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CEW83_RS15130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CEW83_RS15145	COG2226	methyltransferase
CEW83_RS15155	COG0745	RESPONSE REGULATOR receiver
CEW83_RS15175	COG0121	glutamine amidotransferase
CEW83_RS15180	COG2391	methyltransferase activity
CEW83_RS15190	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CEW83_RS15200	COG0154	amidase activity
CEW83_RS15205	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CEW83_RS15210	COG1077	Cell shape determining protein MreB Mrl
CEW83_RS15225	COG0768	penicillin binding
CEW83_RS15230	COG0772	Belongs to the SEDS family
CEW83_RS15240	COG1686	Belongs to the peptidase S11 family
CEW83_RS15250	COG2921	Belongs to the UPF0250 family
CEW83_RS15255	COG0321	lipoyl(octanoyl) transferase activity
CEW83_RS15260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CEW83_RS15275	COG0210	DNA helicase
CEW83_RS15285	COG3706	GGDEF domain
CEW83_RS15290	COG0741	lytic transglycosylase activity
CEW83_RS15300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEW83_RS15315	COG1309	transcriptional regulator
CEW83_RS15320	COG0604	alcohol dehydrogenase
CEW83_RS15345	COG0765	amino acid transport
CEW83_RS15350	COG0765	amino acid transport
CEW83_RS15360	COG0583	DNA-binding transcription factor activity
CEW83_RS15405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CEW83_RS15410	COG0022	dehydrogenase e1 component
CEW83_RS15420	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEW83_RS15425	COG0095	Lipoate-protein ligase
CEW83_RS15450	COG3284	Transcriptional regulator
CEW83_RS15465	COG4628	conserved protein (DUF2132)
CEW83_RS15470	COG2066	Belongs to the glutaminase family
CEW83_RS15500	COG1063	alcohol dehydrogenase
CEW83_RS15510	COG1397	ADP-ribosylglycohydrolase
CEW83_RS15545	COG2755	lipolytic protein G-D-S-L family
CEW83_RS15565	COG0471	metal ion transport
CEW83_RS15585	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CEW83_RS15595	COG1053	succinate dehydrogenase
CEW83_RS15605	COG1012	belongs to the aldehyde dehydrogenase family
CEW83_RS15630	COG0583	DNA-binding transcription factor activity
CEW83_RS15645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CEW83_RS15655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CEW83_RS15660	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CEW83_RS15665	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CEW83_RS15675	COG2815	serine threonine protein kinase
CEW83_RS15675	COG0515	serine threonine protein kinase
CEW83_RS15680	COG1561	YicC-like family, N-terminal region
CEW83_RS15700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW83_RS15720	COG0411	ABC transporter
CEW83_RS15750	COG0194	GDP metabolic process
CEW83_RS15755	COG1758	RNA polymerase activity
CEW83_RS15760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CEW83_RS15770	COG2226	methyltransferase
CEW83_RS15785	COG3850	Histidine kinase
CEW83_RS15790	COG2197	response regulator
CEW83_RS15805	COG0243	molybdopterin cofactor binding
CEW83_RS15810	COG0437	4 iron, 4 sulfur cluster binding
CEW83_RS15815	COG0348	domain, Protein
CEW83_RS15820	COG3043	anaerobic respiration
CEW83_RS15825	COG3005	denitrification pathway
CEW83_RS15830	COG4133	protoheme IX ABC transporter activity
CEW83_RS15835	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CEW83_RS15850	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CEW83_RS15860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEW83_RS15875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CEW83_RS15915	COG0475	glutathione-regulated potassium exporter activity
CEW83_RS15935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CEW83_RS15945	COG0726	polysaccharide deacetylase
CEW83_RS15950	COG1752	Esterase of the alpha-beta hydrolase superfamily
CEW83_RS16000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CEW83_RS16010	COG1131	(ABC) transporter
CEW83_RS16025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CEW83_RS16035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CEW83_RS16060	COG1012	belongs to the aldehyde dehydrogenase family
CEW83_RS16065	COG1024	Enoyl-CoA hydratase
CEW83_RS16070	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW83_RS16075	COG2050	protein possibly involved in aromatic compounds catabolism
CEW83_RS16085	COG3396	Phenylacetate-CoA oxygenase
CEW83_RS16090	COG3460	Phenylacetate-CoA oxygenase
CEW83_RS16095	COG3396	Phenylacetate-CoA oxygenase
CEW83_RS16100	COG2151	metal-sulfur cluster biosynthetic enzyme
CEW83_RS16105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CEW83_RS16115	COG0183	Belongs to the thiolase family
CEW83_RS16150	COG0513	Belongs to the DEAD box helicase family
CEW83_RS16155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEW83_RS16160	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CEW83_RS16175	COG4232	protein-disulfide reductase activity
CEW83_RS16215	COG0534	Mate efflux family protein
CEW83_RS16250	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CEW83_RS16260	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CEW83_RS16265	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CEW83_RS16280	COG4251	negative regulation of phosphorylation
CEW83_RS16280	COG3706	GGDEF domain
CEW83_RS16280	COG5001	Diguanylate cyclase
CEW83_RS16280	COG2203	Gaf domain
CEW83_RS16325	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW83_RS16330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW83_RS16345	COG2824	Alkylphosphonate utilization operon protein PhnA
CEW83_RS16350	COG0366	Alpha amylase catalytic
CEW83_RS16360	COG4178	(ABC) transporter
CEW83_RS16370	COG0366	Alpha amylase catalytic
CEW83_RS16375	COG3300	MHYT domain
CEW83_RS16375	COG5001	Diguanylate cyclase
CEW83_RS16385	COG3706	GGDEF domain
CEW83_RS16410	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CEW83_RS16420	COG2703	oxygen carrier activity
CEW83_RS16425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CEW83_RS16435	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CEW83_RS16440	COG0235	Class ii aldolase
CEW83_RS16460	COG3971	2-oxopent-4-enoate hydratase activity
CEW83_RS16470	COG3384	dioxygenase
CEW83_RS16475	COG1012	belongs to the aldehyde dehydrogenase family
CEW83_RS16485	COG0179	Fumarylacetoacetate (FAA) hydrolase
CEW83_RS16500	COG1846	Transcriptional regulator
CEW83_RS16515	COG1024	Enoyl-CoA hydratase
CEW83_RS16525	COG1024	Enoyl-CoA hydratase
CEW83_RS16535	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEW83_RS16550	COG1131	(ABC) transporter
CEW83_RS16555	COG0625	glutathione transferase activity
CEW83_RS16580	COG0583	DNA-binding transcription factor activity
CEW83_RS16610	COG0642	Histidine kinase
CEW83_RS16630	COG0347	Belongs to the P(II) protein family
CEW83_RS16635	COG0004	ammonium transporteR
CEW83_RS16660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEW83_RS16660	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEW83_RS16670	COG0174	glutamine synthetase
CEW83_RS16675	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CEW83_RS16685	COG0069	glutamate synthase activity
CEW83_RS16690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CEW83_RS16695	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CEW83_RS16710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CEW83_RS16730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEW83_RS16740	COG3850	Histidine kinase
CEW83_RS16745	COG2197	response regulator
CEW83_RS16760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CEW83_RS16765	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CEW83_RS16790	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CEW83_RS16795	COG1522	sequence-specific DNA binding
CEW83_RS16805	COG3154	lipid carrier protein
CEW83_RS16810	COG0826	peptidase U32
CEW83_RS16815	COG0826	peptidase U32
CEW83_RS16825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CEW83_RS16830	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CEW83_RS16835	COG0018	arginyl-trna synthetase
CEW83_RS16845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CEW83_RS16850	COG0300	oxidoreductase activity
CEW83_RS16870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CEW83_RS16880	COG3243	poly(R)-hydroxyalkanoic acid synthase
CEW83_RS16900	COG0288	reversible hydration of carbon dioxide
CEW83_RS16905	COG0183	Belongs to the thiolase family
CEW83_RS16910	COG1960	acyl-CoA dehydrogenase activity
CEW83_RS16935	COG3001	Fructosamine kinase
CEW83_RS16945	COG0625	glutathione transferase activity
CEW83_RS16970	COG1960	acyl-CoA dehydrogenase activity
CEW83_RS16975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CEW83_RS16980	COG1024	Enoyl-CoA hydratase
CEW83_RS16990	COG0318	PFAM AMP-dependent synthetase and ligase
CEW83_RS17015	COG1660	Displays ATPase and GTPase activities
CEW83_RS17030	COG2201	protein-glutamate methylesterase activity
CEW83_RS17040	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CEW83_RS17045	COG0840	transmembrane signaling receptor activity
CEW83_RS17050	COG0835	chemotaxis
CEW83_RS17055	COG0840	transmembrane signaling receptor activity
CEW83_RS17060	COG2198	Histidine kinase
CEW83_RS17060	COG0643	Histidine kinase
CEW83_RS17075	COG0745	RESPONSE REGULATOR receiver
CEW83_RS17080	COG0412	Dienelactone hydrolase
CEW83_RS17085	COG1611	Belongs to the LOG family
CEW83_RS17140	COG1522	sequence-specific DNA binding
CEW83_RS17145	COG0189	ligase activity
CEW83_RS17160	COG0697	spore germination
CEW83_RS17180	COG0788	formyltetrahydrofolate deformylase activity
CEW83_RS17185	COG0004	ammonium transporteR
CEW83_RS17190	COG0347	Belongs to the P(II) protein family
CEW83_RS17205	COG0606	chelatase, subunit chli
CEW83_RS17215	COG0439	Biotin carboxylase
CEW83_RS17220	COG3665	Urea carboxylase-associated protein
CEW83_RS17230	COG1116	anion transmembrane transporter activity
CEW83_RS17245	COG2814	Major facilitator Superfamily
CEW83_RS17390	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CEW83_RS17435	COG3813	Protein conserved in bacteria
CEW83_RS17455	COG2329	Antibiotic biosynthesis monooxygenase
CEW83_RS17480	COG1683	Conserved Protein
CEW83_RS17485	COG2076	Multidrug Resistance protein
CEW83_RS17495	COG0583	DNA-binding transcription factor activity
CEW83_RS17500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEW83_RS17510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CEW83_RS17515	COG3876	Protein conserved in bacteria
CEW83_RS17530	COG0668	transmembrane transport
CEW83_RS17550	COG0180	Tryptophanyl-tRNA synthetase
CEW83_RS17560	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CEW83_RS17565	COG0726	polysaccharide deacetylase
CEW83_RS17605	COG1132	(ABC) transporter
CEW83_RS17615	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CEW83_RS17620	COG0859	PFAM glycosyl transferase family 9
CEW83_RS17630	COG0438	transferase activity, transferring glycosyl groups
CEW83_RS17635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CEW83_RS17650	COG0129	dihydroxy-acid dehydratase activity
CEW83_RS17675	COG2358	TRAP transporter, solute receptor (TAXI family
CEW83_RS17685	COG0745	RESPONSE REGULATOR receiver
CEW83_RS17690	COG2205	protein histidine kinase activity
CEW83_RS17700	COG1280	lysine exporter protein (LysE YggA)
CEW83_RS17715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEW83_RS17720	COG1970	mechanosensitive ion channel activity
CEW83_RS17725	COG2860	membrane
CEW83_RS17735	COG0559	Belongs to the binding-protein-dependent transport system permease family
CEW83_RS17765	COG1194	a g-specific adenine glycosylase
CEW83_RS17770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CEW83_RS17775	COG3706	GGDEF domain
CEW83_RS17780	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CEW83_RS17790	COG1132	(ABC) transporter
CEW83_RS17795	COG0438	transferase activity, transferring glycosyl groups
CEW83_RS17805	COG0438	transferase activity, transferring glycosyl groups
CEW83_RS17810	COG1215	transferase activity, transferring glycosyl groups
CEW83_RS17815	COG0110	maltose O-acetyltransferase activity
CEW83_RS17830	COG1368	sulfuric ester hydrolase activity
CEW83_RS17850	COG0438	transferase activity, transferring glycosyl groups
CEW83_RS17855	COG0859	PFAM glycosyl transferase family 9
CEW83_RS17865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW83_RS17870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CEW83_RS17870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CEW83_RS17880	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CEW83_RS17885	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CEW83_RS17895	COG4206	TonB-dependent receptor
CEW83_RS17900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEW83_RS17905	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CEW83_RS17915	COG1648	precorrin-2 dehydrogenase activity
CEW83_RS17915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CEW83_RS17920	COG1797	cobyrinic acid a,c-diamide synthase activity
CEW83_RS17925	COG1902	pentaerythritol trinitrate reductase activity
CEW83_RS17930	COG0640	Transcriptional regulator
CEW83_RS17940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CEW83_RS17945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEW83_RS17950	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEW83_RS17955	COG0306	phosphate transporter
CEW83_RS17975	COG0488	(ABC) transporter
CEW83_RS17990	COG0826	peptidase U32
CEW83_RS17995	COG0004	ammonium transporteR
CEW83_RS18000	COG2226	methyltransferase
CEW83_RS18020	COG1652	LysM domain
CEW83_RS18040	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CEW83_RS18045	COG0840	transmembrane signaling receptor activity
CEW83_RS18060	COG1671	Belongs to the UPF0178 family
CEW83_RS18065	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CEW83_RS18085	COG1024	Enoyl-CoA hydratase
CEW83_RS18095	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CEW83_RS18100	COG0602	queuosine metabolic process
CEW83_RS18115	COG0823	Involved in the tonB-independent uptake of proteins
CEW83_RS18125	COG0848	biopolymer transport protein
CEW83_RS18135	COG0824	Thioesterase
CEW83_RS18145	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CEW83_RS18150	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CEW83_RS18160	COG3300	MHYT domain
CEW83_RS18160	COG5001	Diguanylate cyclase
CEW83_RS18165	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CEW83_RS18190	COG3128	pkhd-type hydroxylase
CEW83_RS18200	COG4774	siderophore transport
CEW83_RS18210	COG0577	efflux transmembrane transporter activity
CEW83_RS18210	COG1136	(ABC) transporter
CEW83_RS18215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW83_RS18260	COG5001	Diguanylate cyclase
CEW83_RS18260	COG3300	MHYT domain
CEW83_RS18270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CEW83_RS18275	COG3132	Protein of unknown function, DUF480
CEW83_RS18280	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CEW83_RS18300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEW83_RS18320	COG2264	protein methyltransferase activity
CEW83_RS18325	COG0439	Biotin carboxylase
CEW83_RS18330	COG0511	ligase activity, forming carbon-carbon bonds
CEW83_RS18335	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CEW83_RS18340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEW83_RS18350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CEW83_RS18360	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CEW83_RS18365	COG0792	nuclease activity
CEW83_RS18375	COG0418	dihydroorotase activity
CEW83_RS18390	COG2001	Belongs to the MraZ family
CEW83_RS18395	COG0275	rRNA processing
CEW83_RS18410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CEW83_RS18415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CEW83_RS18420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CEW83_RS18425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CEW83_RS18430	COG0772	Belongs to the SEDS family
CEW83_RS18435	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CEW83_RS18440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CEW83_RS18445	COG1181	Belongs to the D-alanine--D-alanine ligase family
CEW83_RS18450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CEW83_RS18465	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CEW83_RS18480	COG0653	protein targeting
CEW83_RS18485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CEW83_RS18490	COG3158	transport of potassium into the cell
CEW83_RS18495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CEW83_RS18505	COG2967	ApaG domain
CEW83_RS18520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEW83_RS18525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEW83_RS18530	COG1862	Preprotein translocase
CEW83_RS18535	COG0343	queuine tRNA-ribosyltransferase activity
CEW83_RS18540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CEW83_RS18550	COG0583	DNA-binding transcription factor activity
CEW83_RS18560	COG0670	Belongs to the BI1 family
CEW83_RS18565	COG0825	malonyl-CoA metabolic process
CEW83_RS18570	COG0037	tRNA processing
CEW83_RS18600	COG1187	pseudouridine synthase activity
CEW83_RS18605	COG1253	flavin adenine dinucleotide binding
CEW83_RS18610	COG0861	Integral membrane protein TerC family
CEW83_RS18625	COG1136	(ABC) transporter
CEW83_RS18625	COG0577	efflux transmembrane transporter activity
CEW83_RS18630	COG1136	(ABC) transporter
CEW83_RS18630	COG0577	efflux transmembrane transporter activity
CEW83_RS18635	COG1136	(ABC) transporter
CEW83_RS18635	COG0577	efflux transmembrane transporter activity
CEW83_RS18645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEW83_RS18650	COG0668	transmembrane transport
CEW83_RS18655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CEW83_RS18660	COG2885	chlorophyll binding
CEW83_RS18665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CEW83_RS18675	COG4647	ligase activity
CEW83_RS18680	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CEW83_RS18685	COG0145	ligase activity
CEW83_RS18690	COG3284	Transcriptional regulator
CEW83_RS18695	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CEW83_RS18700	COG0351	phosphomethylpyrimidine kinase
CEW83_RS18710	COG1136	(ABC) transporter
CEW83_RS18710	COG0577	efflux transmembrane transporter activity
CEW83_RS18735	COG0489	protein tyrosine kinase activity
CEW83_RS18745	COG3267	Type II secretory pathway component ExeA
CEW83_RS18745	COG3409	Peptidoglycan-binding domain 1 protein
CEW83_RS18775	COG0367	asparagine synthase
CEW83_RS18780	COG0438	transferase activity, transferring glycosyl groups
CEW83_RS18785	COG0367	asparagine synthase
CEW83_RS18805	COG0297	glycogen (starch) synthase activity
CEW83_RS18840	COG2327	Polysaccharide pyruvyl transferase
CEW83_RS18850	COG0438	transferase activity, transferring glycosyl groups
CEW83_RS18895	COG0367	asparagine synthase
CEW83_RS18910	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CEW83_RS18915	COG0071	Belongs to the small heat shock protein (HSP20) family
CEW83_RS18940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CEW83_RS18950	COG0741	lytic transglycosylase activity
CEW83_RS18955	COG0436	Aminotransferase
CEW83_RS18960	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CEW83_RS18965	COG0281	malic enzyme
CEW83_RS18965	COG0280	phosphate acetyltransferase
CEW83_RS18985	COG2111	Na H antiporter
CEW83_RS18985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CEW83_RS18990	COG1006	Multisubunit Na H antiporter MnhC subunit
CEW83_RS18995	COG0651	ATP synthesis coupled electron transport
CEW83_RS19000	COG1863	multisubunit Na H antiporter MnhE subunit
CEW83_RS19005	COG2212	antiporter activity
CEW83_RS19010	COG1320	monovalent cation:proton antiporter activity
CEW83_RS19015	COG1320	monovalent cation:proton antiporter activity
CEW83_RS19020	COG2212	antiporter activity
CEW83_RS19025	COG1863	multisubunit Na H antiporter MnhE subunit
CEW83_RS19030	COG0651	ATP synthesis coupled electron transport
CEW83_RS19040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CEW83_RS19040	COG2111	Na H antiporter
CEW83_RS19045	COG0105	UTP biosynthetic process
CEW83_RS19050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CEW83_RS19065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CEW83_RS19070	COG0124	histidyl-tRNA synthetase
CEW83_RS19075	COG2976	Protein conserved in bacteria
CEW83_RS19085	COG1160	GTP binding
CEW83_RS19090	COG1923	regulation of RNA biosynthetic process
CEW83_RS19095	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CEW83_RS19100	COG0330	HflC and HflK could
CEW83_RS19105	COG0330	HflC and HflK could
CEW83_RS19115	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CEW83_RS19120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CEW83_RS19140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CEW83_RS19145	COG3707	response regulator
CEW83_RS19150	COG1116	anion transmembrane transporter activity
CEW83_RS19150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW83_RS19155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW83_RS19160	COG1116	anion transmembrane transporter activity
CEW83_RS19170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEW83_RS19175	COG2146	nitrite reductase [NAD(P)H] activity
CEW83_RS19185	COG0517	IMP dehydrogenase activity
CEW83_RS19190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEW83_RS19220	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CEW83_RS19225	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CEW83_RS19230	COG0723	plastoquinol--plastocyanin reductase activity
CEW83_RS19235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CEW83_RS19240	COG2857	Cytochrome c1
CEW83_RS19245	COG0625	glutathione transferase activity
CEW83_RS19250	COG2969	positive regulation of protein catabolic process
CEW83_RS19255	COG0438	transferase activity, transferring glycosyl groups
CEW83_RS19265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW83_RS19270	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CEW83_RS19280	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CEW83_RS19285	COG0459	protein refolding
CEW83_RS19295	COG0642	Histidine kinase
CEW83_RS19300	COG3162	membrane
CEW83_RS19325	COG3046	protein related to deoxyribodipyrimidine photolyase
CEW83_RS19330	COG0415	Belongs to the DNA photolyase family
CEW83_RS19345	COG2902	Dehydrogenase
CEW83_RS19350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CEW83_RS19355	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CEW83_RS19360	COG2890	protein-(glutamine-N5) methyltransferase activity
CEW83_RS19365	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CEW83_RS19390	COG2815	serine threonine protein kinase
CEW83_RS19390	COG0515	serine threonine protein kinase
CEW83_RS19395	COG0165	Argininosuccinate lyase
CEW83_RS19440	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CEW83_RS19450	COG0181	hydroxymethylbilane synthase activity
CEW83_RS19460	COG2959	enzyme of heme biosynthesis
CEW83_RS19470	COG0659	secondary active sulfate transmembrane transporter activity
CEW83_RS19475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEW83_RS19475	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEW83_RS19485	COG0489	protein tyrosine kinase activity
CEW83_RS19490	COG0717	Belongs to the dCTP deaminase family
CEW83_RS19505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CEW83_RS19645	COG3411	Ferredoxin
CEW83_RS19660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CEW83_RS19685	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CEW83_RS19690	COG0393	Putative heavy-metal-binding
CEW83_RS19700	COG0217	transcriptional regulatory protein
CEW83_RS19705	COG0433	COG0433 Predicted ATPase
CEW83_RS19710	COG0697	spore germination
CEW83_RS19715	COG0840	transmembrane signaling receptor activity
CEW83_RS19720	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CEW83_RS19725	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CEW83_RS19730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW83_RS19730	COG3153	acetyltransferase
CEW83_RS19735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW83_RS19735	COG3153	acetyltransferase
CEW83_RS19740	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CEW83_RS19750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CEW83_RS19760	COG1560	Kdo2-lipid A biosynthetic process
CEW83_RS19770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CEW83_RS19790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CEW83_RS19800	COG2255	four-way junction helicase activity
CEW83_RS19805	COG0632	four-way junction helicase activity
CEW83_RS19810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CEW83_RS19820	COG1530	ribonuclease E activity
CEW83_RS19825	COG0424	maF-like protein
CEW83_RS19830	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CEW83_RS19835	COG0799	negative regulation of ribosome biogenesis
CEW83_RS19840	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CEW83_RS19855	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CEW83_RS19880	COG1088	dTDP-glucose 4,6-dehydratase activity
CEW83_RS19885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CEW83_RS19895	COG2089	acid synthase
CEW83_RS19900	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CEW83_RS19905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW83_RS19905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CEW83_RS19915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CEW83_RS19925	COG1083	cytidylyl-transferase
CEW83_RS19935	COG2192	nodulation
CEW83_RS19940	COG1028	Short-chain dehydrogenase reductase Sdr
CEW83_RS19950	COG2226	methyltransferase
CEW83_RS19965	COG0110	maltose O-acetyltransferase activity
CEW83_RS19975	COG1215	transferase activity, transferring glycosyl groups
CEW83_RS19980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW83_RS19985	COG1215	transferase activity, transferring glycosyl groups
CEW83_RS19990	COG1216	Glycosyl transferase, family 2
CEW83_RS19995	COG0438	transferase activity, transferring glycosyl groups
CEW83_RS20000	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CEW83_RS20010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CEW83_RS20020	COG2192	nodulation
CEW83_RS20030	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CEW83_RS20035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CEW83_RS20040	COG2233	PERMEase
CEW83_RS20060	COG0708	Exodeoxyribonuclease III
CEW83_RS20065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CEW83_RS20075	COG0243	molybdopterin cofactor binding
CEW83_RS20090	COG0251	oxidation-reduction process
CEW83_RS20095	COG1238	metal cluster binding
CEW83_RS20110	COG0037	tRNA processing
CEW83_RS20115	COG1028	Short-chain dehydrogenase reductase Sdr
CEW83_RS20135	COG0625	glutathione transferase activity
CEW83_RS20145	COG0617	tRNA 3'-terminal CCA addition
CEW83_RS20155	COG0702	epimerase
CEW83_RS20160	COG0741	lytic transglycosylase activity
CEW83_RS20165	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CEW83_RS20180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CEW83_RS20185	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CEW83_RS20195	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CEW83_RS20200	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CEW83_RS20210	COG2137	regulation of response to DNA damage stimulus
CEW83_RS20215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CEW83_RS20220	COG1546	Belongs to the CinA family
CEW83_RS20225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CEW83_RS20230	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CEW83_RS20235	COG3300	MHYT domain
CEW83_RS20235	COG5001	Diguanylate cyclase
CEW83_RS20260	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CEW83_RS20265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CEW83_RS20270	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CEW83_RS20285	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CEW83_RS20290	COG4974	Belongs to the 'phage' integrase family
CEW83_RS20295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CEW83_RS20300	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CEW83_RS20305	COG1466	dna polymerase III delta subunit
CEW83_RS20315	COG0495	leucyl-tRNA aminoacylation
CEW83_RS20325	COG0210	DNA helicase
CEW83_RS20330	COG1192	Involved in chromosome partitioning
CEW83_RS20335	COG0281	malic enzyme
CEW83_RS20335	COG0280	phosphate acetyltransferase
CEW83_RS20350	COG0668	transmembrane transport
CEW83_RS20360	COG0408	coproporphyrinogen oxidase activity
CEW83_RS20365	COG3422	double-strand break repair
CEW83_RS20370	COG0151	Belongs to the GarS family
CEW83_RS20375	COG0138	bifunctional purine biosynthesis protein purh
CEW83_RS20380	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CEW83_RS20390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEW83_RS20395	COG0006	proline dipeptidase activity
CEW83_RS20410	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CEW83_RS20415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEW83_RS20420	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CEW83_RS20425	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CEW83_RS20445	COG0004	ammonium transporteR
CEW83_RS20470	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CEW83_RS20485	COG2353	YceI-like domain
CEW83_RS20495	COG3038	cytochrome b561
CEW83_RS20500	COG3384	dioxygenase
CEW83_RS20510	COG3437	response regulator, receiver
CEW83_RS20515	COG2198	Histidine kinase
CEW83_RS20515	COG0784	Response regulator, receiver
CEW83_RS20515	COG2205	protein histidine kinase activity
CEW83_RS20525	COG2828	Protein conserved in bacteria
CEW83_RS20530	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CEW83_RS20545	COG0191	fructose-bisphosphate aldolase activity
CEW83_RS20550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CEW83_RS20560	COG3954	Phosphoribulokinase
CEW83_RS20565	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CEW83_RS20575	COG4451	ribulose bisphosphate carboxylase, small
CEW83_RS20605	COG0469	pyruvate kinase activity
CEW83_RS20615	COG0126	phosphoglycerate kinase activity
CEW83_RS20625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CEW83_RS20630	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CEW83_RS20635	COG3954	Phosphoribulokinase
CEW83_RS20645	COG0483	inositol monophosphate 1-phosphatase activity
CEW83_RS20650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CEW83_RS20660	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CEW83_RS20660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CEW83_RS20670	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CEW83_RS20675	COG0704	Plays a role in the regulation of phosphate uptake
CEW83_RS20680	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CEW83_RS20685	COG0303	'Molybdopterin
CEW83_RS20690	COG2833	Protein of unknown function (DUF455)
CEW83_RS20700	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CEW83_RS20715	COG2226	methyltransferase
CEW83_RS20720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CEW83_RS20725	COG1040	competence protein
CEW83_RS20730	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CEW83_RS20735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CEW83_RS20745	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CEW83_RS20755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CEW83_RS20765	COG0588	phosphoglycerate mutase activity
CEW83_RS20775	COG0793	Belongs to the peptidase S41A family
CEW83_RS20790	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CEW83_RS20790	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CEW83_RS20795	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CEW83_RS20800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CEW83_RS20820	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CEW83_RS20825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CEW83_RS20825	COG4651	solute:proton antiporter activity
CEW83_RS20835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CEW83_RS20845	COG0402	S-adenosylhomocysteine deaminase activity
CEW83_RS20850	COG2815	serine threonine protein kinase
CEW83_RS20850	COG0515	serine threonine protein kinase
CEW83_RS20855	COG1950	PFAM Membrane protein of
CEW83_RS20860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CEW83_RS20865	COG1420	regulation of RNA biosynthetic process
CEW83_RS20870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CEW83_RS20875	COG0497	DNA recombination
CEW83_RS20880	COG0735	belongs to the Fur family
CEW83_RS20885	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEW83_RS20890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CEW83_RS20900	COG0505	Belongs to the CarA family
CEW83_RS20910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CEW83_RS20920	COG1534	Rna-binding protein
CEW83_RS20925	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit