locus-tag	class	description
G3580_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G3580_RS00010	COG0592	DNA-directed DNA polymerase activity
G3580_RS00070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G3580_RS00080	COG1234	tRNA 3'-trailer cleavage
G3580_RS00085	COG1959	2 iron, 2 sulfur cluster binding
G3580_RS00090	COG0719	Fe-S assembly protein
G3580_RS00095	COG0396	ATPase activity
G3580_RS00100	COG0719	Fe-S assembly protein
G3580_RS00110	COG0822	iron-sulfur transferase activity
G3580_RS00115	COG2151	metal-sulfur cluster biosynthetic enzyme
G3580_RS00130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G3580_RS00135	COG1063	alcohol dehydrogenase
G3580_RS00140	COG4647	ligase activity
G3580_RS00145	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
G3580_RS00150	COG0145	ligase activity
G3580_RS00165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G3580_RS00180	COG1132	(ABC) transporter
G3580_RS00185	COG1404	Belongs to the peptidase S8 family
G3580_RS00205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G3580_RS00210	COG0583	DNA-binding transcription factor activity
G3580_RS00230	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G3580_RS00240	COG1902	pentaerythritol trinitrate reductase activity
G3580_RS00265	COG0741	lytic transglycosylase activity
G3580_RS00265	COG0739	heme binding
G3580_RS00265	COG1196	nuclear chromosome segregation
G3580_RS00290	COG1459	type II secretion system
G3580_RS00320	COG1450	Type ii and iii secretion system protein
G3580_RS00330	COG2165	general secretion pathway protein
G3580_RS00345	COG2197	response regulator
G3580_RS00370	COG0811	peptide transport
G3580_RS00425	COG1942	4-Oxalocrotonate Tautomerase
G3580_RS00435	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
G3580_RS00525	COG2204	response regulator
G3580_RS00530	COG4191	Histidine kinase
G3580_RS00550	COG4569	acetaldehyde dehydrogenase (acetylating) activity
G3580_RS00555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3580_RS00575	COG2249	NAD(P)H dehydrogenase (quinone) activity
G3580_RS00625	COG4191	Histidine kinase
G3580_RS00630	COG2204	response regulator
G3580_RS00635	COG1525	nuclease
G3580_RS00635	COG4085	toxin activity
G3580_RS00635	COG0737	Belongs to the 5'-nucleotidase family
G3580_RS00650	COG3501	Rhs element vgr protein
G3580_RS00690	COG1918	ferrous iron import across plasma membrane
G3580_RS00695	COG1690	Belongs to the RtcB family
G3580_RS00705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G3580_RS00720	COG0500	methyltransferase
G3580_RS00785	COG0330	HflC and HflK could
G3580_RS00800	COG0803	Belongs to the bacterial solute-binding protein 9 family
G3580_RS00805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G3580_RS00850	COG0523	cobalamin synthesis protein
G3580_RS00875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G3580_RS00885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G3580_RS00895	COG0783	Belongs to the Dps family
G3580_RS00905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G3580_RS00905	COG0551	DNA topoisomerase type I activity
G3580_RS00910	COG2922	Belongs to the Smg family
G3580_RS00915	COG0758	DNA mediated transformation
G3580_RS00920	COG1652	LysM domain
G3580_RS00925	COG0242	peptide deformylase activity
G3580_RS00930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G3580_RS00935	COG0501	Belongs to the peptidase M48B family
G3580_RS00940	COG2204	response regulator
G3580_RS00945	COG4191	Histidine kinase
G3580_RS00965	COG3383	formate dehydrogenase (NAD+) activity
G3580_RS00970	COG0437	4 iron, 4 sulfur cluster binding
G3580_RS00985	COG0746	molybdenum cofactor guanylyltransferase activity
G3580_RS00990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G3580_RS01020	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G3580_RS01025	COG1595	DNA-templated transcription, initiation
G3580_RS01035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3580_RS01040	COG0754	glutathionylspermidine amidase activity
G3580_RS01045	COG1573	uracil-dna glycosylase
G3580_RS01065	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
G3580_RS01080	COG0445	tRNA wobble uridine modification
G3580_RS01085	COG0357	Ribosomal RNA small subunit methyltransferase G
G3580_RS01090	COG1192	Involved in chromosome partitioning
G3580_RS01095	COG1475	DNA binding
G3580_RS01105	COG0356	it plays a direct role in the translocation of protons across the membrane
G3580_RS01115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G3580_RS01120	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G3580_RS01125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G3580_RS01130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G3580_RS01135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G3580_RS01140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G3580_RS01150	COG2226	methyltransferase
G3580_RS01160	COG0745	RESPONSE REGULATOR receiver
G3580_RS01180	COG0121	glutamine amidotransferase
G3580_RS01195	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G3580_RS01205	COG0154	amidase activity
G3580_RS01210	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G3580_RS01215	COG1077	Cell shape determining protein MreB Mrl
G3580_RS01230	COG0768	penicillin binding
G3580_RS01235	COG0772	Belongs to the SEDS family
G3580_RS01245	COG1686	Belongs to the peptidase S11 family
G3580_RS01255	COG2921	Belongs to the UPF0250 family
G3580_RS01260	COG0321	lipoyl(octanoyl) transferase activity
G3580_RS01265	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G3580_RS01325	COG0210	DNA helicase
G3580_RS01355	COG0318	PFAM AMP-dependent synthetase and ligase
G3580_RS01360	COG0183	Belongs to the thiolase family
G3580_RS01385	COG1033	growth of symbiont in host cell
G3580_RS01385	COG2409	Drug exporters of the RND superfamily
G3580_RS01405	COG0145	ligase activity
G3580_RS01410	COG4647	ligase activity
G3580_RS01415	COG0145	ligase activity
G3580_RS01430	COG0523	cobalamin synthesis protein
G3580_RS01440	COG2072	flavoprotein involved in K transport
G3580_RS01445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3580_RS01480	COG2204	response regulator
G3580_RS01495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3580_RS01500	COG0745	RESPONSE REGULATOR receiver
G3580_RS01505	COG1970	mechanosensitive ion channel activity
G3580_RS01515	COG5002	protein histidine kinase activity
G3580_RS01540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3580_RS01545	COG4597	amino acid ABC transporter
G3580_RS01550	COG0765	amino acid transport
G3580_RS01555	COG1126	abc transporter atp-binding protein
G3580_RS01590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3580_RS01595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G3580_RS01610	COG2022	thiamine diphosphate biosynthetic process
G3580_RS01615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G3580_RS01620	COG0616	signal peptide processing
G3580_RS01630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G3580_RS01635	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G3580_RS01640	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G3580_RS01645	COG0631	protein serine/threonine phosphatase activity
G3580_RS01650	COG0515	serine threonine protein kinase
G3580_RS01650	COG3266	domain, Protein
G3580_RS01655	COG1561	YicC-like family, N-terminal region
G3580_RS01675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G3580_RS01680	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G3580_RS01685	COG2070	2-Nitropropane dioxygenase
G3580_RS01695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G3580_RS01710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G3580_RS01725	COG2304	oxidoreductase activity
G3580_RS01780	COG1028	Short-chain dehydrogenase reductase Sdr
G3580_RS01800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G3580_RS01850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G3580_RS01865	COG4771	TonB-dependent receptor
G3580_RS01880	COG0028	Belongs to the TPP enzyme family
G3580_RS01890	COG0251	oxidation-reduction process
G3580_RS01915	COG1238	metal cluster binding
G3580_RS01920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G3580_RS01940	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G3580_RS01945	COG0741	lytic transglycosylase activity
G3580_RS01955	COG0617	tRNA 3'-terminal CCA addition
G3580_RS01960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G3580_RS01990	COG0037	tRNA processing
G3580_RS02005	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G3580_RS02015	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G3580_RS02020	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G3580_RS02025	COG1137	ATPase activity
G3580_RS02030	COG2137	regulation of response to DNA damage stimulus
G3580_RS02035	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G3580_RS02040	COG1546	Belongs to the CinA family
G3580_RS02045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G3580_RS02055	COG0367	asparagine synthase
G3580_RS02060	COG0189	ligase activity
G3580_RS02060	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G3580_RS02065	COG1363	Peptidase, m42
G3580_RS02075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G3580_RS02080	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G3580_RS02100	COG1881	PFAM PEBP family protein
G3580_RS02105	COG4232	protein-disulfide reductase activity
G3580_RS02110	COG1324	tolerance protein
G3580_RS02115	COG0842	Transport permease protein
G3580_RS02120	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G3580_RS02120	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G3580_RS02135	COG1131	(ABC) transporter
G3580_RS02140	COG0625	glutathione transferase activity
G3580_RS02145	COG2945	thiolester hydrolase activity
G3580_RS02145	COG0596	Alpha beta hydrolase
G3580_RS02150	COG3411	Ferredoxin
G3580_RS02160	COG3154	lipid carrier protein
G3580_RS02165	COG0826	peptidase U32
G3580_RS02170	COG0826	peptidase U32
G3580_RS02175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G3580_RS02180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G3580_RS02200	COG0018	arginyl-trna synthetase
G3580_RS02210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G3580_RS02215	COG0300	oxidoreductase activity
G3580_RS02235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G3580_RS02245	COG3243	poly(R)-hydroxyalkanoic acid synthase
G3580_RS02265	COG1960	acyl-CoA dehydrogenase activity
G3580_RS02270	COG0288	reversible hydration of carbon dioxide
G3580_RS02275	COG0183	Belongs to the thiolase family
G3580_RS02280	COG1960	acyl-CoA dehydrogenase activity
G3580_RS02300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G3580_RS02320	COG0318	PFAM AMP-dependent synthetase and ligase
G3580_RS02340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3580_RS02370	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G3580_RS02375	COG1660	Displays ATPase and GTPase activities
G3580_RS02395	COG0412	Dienelactone hydrolase
G3580_RS02410	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
G3580_RS02415	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G3580_RS02435	COG1741	Belongs to the pirin family
G3580_RS02445	COG2119	membrane
G3580_RS02450	COG1309	transcriptional regulator
G3580_RS02460	COG1131	(ABC) transporter
G3580_RS02465	COG0842	Transport permease protein
G3580_RS02470	COG0842	Transport permease protein
G3580_RS02500	COG0545	Peptidyl-prolyl cis-trans isomerase
G3580_RS02505	COG1309	transcriptional regulator
G3580_RS02510	COG0604	alcohol dehydrogenase
G3580_RS02520	COG0583	DNA-binding transcription factor activity
G3580_RS02535	COG1556	Lactate utilization protein
G3580_RS02540	COG1139	Iron-sulfur cluster binding protein
G3580_RS02545	COG0247	lactate metabolic process
G3580_RS02550	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G3580_RS02560	COG0393	Putative heavy-metal-binding
G3580_RS02575	COG4633	Protein conserved in bacteria
G3580_RS02580	COG0672	)-iron permease
G3580_RS02590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G3580_RS02600	COG1560	Kdo2-lipid A biosynthetic process
G3580_RS02610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G3580_RS02620	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G3580_RS02670	COG2255	four-way junction helicase activity
G3580_RS02675	COG0632	four-way junction helicase activity
G3580_RS02690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G3580_RS02700	COG1530	ribonuclease E activity
G3580_RS02705	COG0424	maF-like protein
G3580_RS02710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G3580_RS02715	COG0799	negative regulation of ribosome biogenesis
G3580_RS02720	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G3580_RS02735	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G3580_RS02745	COG3284	Transcriptional regulator
G3580_RS02780	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3580_RS02790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G3580_RS02790	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G3580_RS02815	COG1285	pathogenesis
G3580_RS02825	COG2203	Gaf domain
G3580_RS02825	COG5001	Diguanylate cyclase
G3580_RS02825	COG4251	negative regulation of phosphorylation
G3580_RS02825	COG3706	GGDEF domain
G3580_RS02835	COG1793	dna ligase
G3580_RS02840	COG2951	lytic endotransglycosylase activity
G3580_RS02850	COG0726	polysaccharide deacetylase
G3580_RS02855	COG0438	transferase activity, transferring glycosyl groups
G3580_RS02860	COG0438	transferase activity, transferring glycosyl groups
G3580_RS02880	COG0438	transferase activity, transferring glycosyl groups
G3580_RS02900	COG1132	(ABC) transporter
G3580_RS02910	COG0406	alpha-ribazole phosphatase activity
G3580_RS02915	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
G3580_RS02920	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G3580_RS02930	COG4206	TonB-dependent receptor
G3580_RS02940	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G3580_RS02955	COG1648	precorrin-2 dehydrogenase activity
G3580_RS02955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G3580_RS02965	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G3580_RS02970	COG0602	queuosine metabolic process
G3580_RS02985	COG0823	Involved in the tonB-independent uptake of proteins
G3580_RS03000	COG0811	peptide transport
G3580_RS03005	COG0824	Thioesterase
G3580_RS03015	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G3580_RS03020	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G3580_RS03045	COG2354	Protein conserved in bacteria
G3580_RS03055	COG0730	response to heat
G3580_RS03085	COG1834	amidinotransferase
G3580_RS03090	COG2423	ornithine cyclodeaminase activity
G3580_RS03115	COG2895	sulfate adenylyltransferase (ATP) activity
G3580_RS03125	COG0175	sulfate reduction
G3580_RS03140	COG0730	response to heat
G3580_RS03145	COG0583	DNA-binding transcription factor activity
G3580_RS03155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3580_RS03170	COG5265	(ABC) transporter
G3580_RS03180	COG3647	Membrane
G3580_RS03185	COG2205	protein histidine kinase activity
G3580_RS03190	COG0745	RESPONSE REGULATOR receiver
G3580_RS03205	COG1960	acyl-CoA dehydrogenase activity
G3580_RS03210	COG0183	Belongs to the thiolase family
G3580_RS03220	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3580_RS03220	COG1024	Enoyl-CoA hydratase
G3580_RS03225	COG1607	acyl-coa hydrolase
G3580_RS03230	COG2067	long-chain fatty acid transport protein
G3580_RS03235	COG1024	Enoyl-CoA hydratase
G3580_RS03235	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3580_RS03240	COG0183	Belongs to the thiolase family
G3580_RS03270	COG0745	RESPONSE REGULATOR receiver
G3580_RS03320	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
G3580_RS03330	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G3580_RS03335	COG3161	chorismate lyase activity
G3580_RS03340	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G3580_RS03350	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
G3580_RS03360	COG1489	DNA binding
G3580_RS03370	COG1196	nuclear chromosome segregation
G3580_RS03370	COG0739	heme binding
G3580_RS03370	COG0741	lytic transglycosylase activity
G3580_RS03375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G3580_RS03430	COG1215	transferase activity, transferring glycosyl groups
G3580_RS03475	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G3580_RS03480	COG1088	dTDP-glucose 4,6-dehydratase activity
G3580_RS03520	COG1965	Belongs to the frataxin family
G3580_RS03555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G3580_RS03560	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G3580_RS03565	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G3580_RS03570	COG0069	glutamate synthase activity
G3580_RS03570	COG0067	glutamate synthase
G3580_RS03570	COG0070	glutamate synthase
G3580_RS03590	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G3580_RS03595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G3580_RS03625	COG0643	Histidine kinase
G3580_RS03625	COG2198	Histidine kinase
G3580_RS03630	COG0840	transmembrane signaling receptor activity
G3580_RS03640	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G3580_RS03650	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
G3580_RS03655	COG4191	Histidine kinase
G3580_RS03670	COG3243	poly(R)-hydroxyalkanoic acid synthase
G3580_RS03680	COG4191	Histidine kinase
G3580_RS03685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3580_RS03735	COG2989	Protein conserved in bacteria
G3580_RS03740	COG3108	Peptidase M15
G3580_RS03760	COG0583	DNA-binding transcription factor activity
G3580_RS03765	COG3622	Belongs to the hyi family
G3580_RS03775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3580_RS03855	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3580_RS03865	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G3580_RS03870	COG3132	Protein of unknown function, DUF480
G3580_RS03875	COG0166	Belongs to the GPI family
G3580_RS03880	COG0129	dihydroxy-acid dehydratase activity
G3580_RS03890	COG0625	glutathione transferase activity
G3580_RS03900	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
G3580_RS03910	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
G3580_RS03945	COG1773	rubredoxin
G3580_RS03965	COG0375	protein maturation
G3580_RS03975	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
G3580_RS03980	COG0298	carbon dioxide binding
G3580_RS03985	COG0409	Hydrogenase expression formation protein
G3580_RS03995	COG0309	Hydrogenase expression formation protein (HypE)
G3580_RS04000	COG1024	Enoyl-CoA hydratase
G3580_RS04000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G3580_RS04005	COG2204	response regulator
G3580_RS04010	COG0306	phosphate transporter
G3580_RS04020	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
G3580_RS04035	COG4654	Cytochrome c, class I
G3580_RS04050	COG3852	Histidine kinase
G3580_RS04055	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
G3580_RS04105	COG1872	DUF167
G3580_RS04110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G3580_RS04115	COG0540	Belongs to the ATCase OTCase family
G3580_RS04120	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
G3580_RS04125	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G3580_RS04130	COG1678	Uncharacterized ACR, COG1678
G3580_RS04135	COG0415	Belongs to the DNA photolyase family
G3580_RS04140	COG0643	Histidine kinase
G3580_RS04140	COG2198	Histidine kinase
G3580_RS04140	COG0784	Response regulator, receiver
G3580_RS04175	COG0352	thiamine-phosphate diphosphorylase activity
G3580_RS04180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G3580_RS04195	COG2239	Acts as a magnesium transporter
G3580_RS04200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G3580_RS04205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G3580_RS04215	COG0557	exoribonuclease II activity
G3580_RS04220	COG2962	Rard protein
G3580_RS04225	COG2226	methyltransferase
G3580_RS04230	COG3150	esterase
G3580_RS04235	COG1968	undecaprenyl-diphosphatase activity
G3580_RS04275	COG2304	oxidoreductase activity
G3580_RS04295	COG0714	Associated with various cellular activities
G3580_RS04310	COG1131	(ABC) transporter
G3580_RS04325	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G3580_RS04330	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G3580_RS04365	COG3284	Transcriptional regulator
G3580_RS04370	COG3199	ATP-NAD kinase
G3580_RS04375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G3580_RS04380	COG0022	dehydrogenase e1 component
G3580_RS04390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G3580_RS04405	COG2022	thiamine diphosphate biosynthetic process
G3580_RS04410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G3580_RS04415	COG1764	response to oxidative stress
G3580_RS04430	COG1278	Cold shock
G3580_RS04440	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G3580_RS04445	COG0366	Alpha amylase catalytic
G3580_RS04450	COG0351	phosphomethylpyrimidine kinase
G3580_RS04455	COG3338	carbonate dehydratase activity
G3580_RS04460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G3580_RS04475	COG1309	transcriptional regulator
G3580_RS04490	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G3580_RS04495	COG0425	Belongs to the sulfur carrier protein TusA family
G3580_RS04495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G3580_RS04515	COG1132	(ABC) transporter
G3580_RS04520	COG1091	dTDP-4-dehydrorhamnose reductase activity
G3580_RS04525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G3580_RS04540	COG1028	Short-chain dehydrogenase reductase Sdr
G3580_RS04545	COG1083	cytidylyl-transferase
G3580_RS04550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G3580_RS04560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G3580_RS04585	COG2089	acid synthase
G3580_RS04600	COG0363	glucosamine-6-phosphate deaminase activity
G3580_RS04605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G3580_RS04610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G3580_RS04630	COG2171	N-acyltransferase activity
G3580_RS04635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G3580_RS04640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3580_RS04645	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G3580_RS04660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G3580_RS04665	COG0438	transferase activity, transferring glycosyl groups
G3580_RS04700	COG1086	Polysaccharide biosynthesis protein
G3580_RS04715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G3580_RS04725	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G3580_RS04775	COG2264	protein methyltransferase activity
G3580_RS04780	COG0439	Biotin carboxylase
G3580_RS04785	COG0511	ligase activity, forming carbon-carbon bonds
G3580_RS04790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G3580_RS04795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G3580_RS04805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G3580_RS04815	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
G3580_RS04820	COG0792	nuclease activity
G3580_RS04830	COG0418	dihydroorotase activity
G3580_RS04850	COG2001	Belongs to the MraZ family
G3580_RS04855	COG0275	rRNA processing
G3580_RS04870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G3580_RS04875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G3580_RS04890	COG0772	Belongs to the SEDS family
G3580_RS04895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G3580_RS04900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G3580_RS04905	COG1181	Belongs to the D-alanine--D-alanine ligase family
G3580_RS04910	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G3580_RS04920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G3580_RS04925	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
G3580_RS04940	COG0653	protein targeting
G3580_RS04950	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G3580_RS04990	COG2967	ApaG domain
G3580_RS04995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G3580_RS05000	COG0546	phosphoglycolate phosphatase activity
G3580_RS05010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G3580_RS05025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G3580_RS05030	COG0134	indole-3-glycerol-phosphate synthase activity
G3580_RS05050	COG1301	dicarboxylic acid transport
G3580_RS05055	COG2902	Dehydrogenase
G3580_RS05085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G3580_RS05090	COG0514	ATP-dependent DNA helicase (RecQ)
G3580_RS05095	COG2852	Protein conserved in bacteria
G3580_RS05110	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G3580_RS05125	COG0386	Belongs to the glutathione peroxidase family
G3580_RS05140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G3580_RS05160	COG0300	oxidoreductase activity
G3580_RS05175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G3580_RS05180	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
G3580_RS05200	COG3346	SURF1 family
G3580_RS05215	COG0109	protoheme IX farnesyltransferase activity
G3580_RS05220	COG1999	signal sequence binding
G3580_RS05230	COG2274	protein secretion by the type I secretion system
G3580_RS05235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3580_RS05240	COG2197	response regulator
G3580_RS05265	COG1538	Outer membrane efflux protein
G3580_RS05270	COG0114	fumarate hydratase activity
G3580_RS05280	COG3162	membrane
G3580_RS05285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G3580_RS05295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G3580_RS05300	COG0069	glutamate synthase activity
G3580_RS05310	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
G3580_RS05315	COG0174	glutamine synthetase
G3580_RS05325	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G3580_RS05325	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3580_RS05350	COG0004	ammonium transporteR
G3580_RS05355	COG0347	Belongs to the P(II) protein family
G3580_RS05365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G3580_RS05370	COG0459	protein refolding
G3580_RS05375	COG0745	RESPONSE REGULATOR receiver
G3580_RS05380	COG0642	Histidine kinase
G3580_RS05390	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G3580_RS05395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G3580_RS05400	COG2890	protein-(glutamine-N5) methyltransferase activity
G3580_RS05405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G3580_RS05430	COG3001	Fructosamine kinase
G3580_RS05435	COG0515	serine threonine protein kinase
G3580_RS05435	COG2815	serine threonine protein kinase
G3580_RS05440	COG0165	Argininosuccinate lyase
G3580_RS05445	COG3275	phosphorelay sensor kinase activity
G3580_RS05460	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G3580_RS05470	COG0181	hydroxymethylbilane synthase activity
G3580_RS05485	COG0408	coproporphyrinogen oxidase activity
G3580_RS05495	COG0151	Belongs to the GarS family
G3580_RS05505	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
G3580_RS05515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3580_RS05520	COG0006	proline dipeptidase activity
G3580_RS05535	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G3580_RS05540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G3580_RS05545	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G3580_RS05550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G3580_RS05560	COG0840	transmembrane signaling receptor activity
G3580_RS05580	COG5001	Diguanylate cyclase
G3580_RS05580	COG3300	MHYT domain
G3580_RS05585	COG0339	signal peptide processing
G3580_RS05595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G3580_RS05605	COG1696	Membrane protein involved in D-alanine export
G3580_RS05625	COG0778	Nitroreductase
G3580_RS05640	COG0126	phosphoglycerate kinase activity
G3580_RS05645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G3580_RS05650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G3580_RS05655	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G3580_RS05665	COG0483	inositol monophosphate 1-phosphatase activity
G3580_RS05670	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G3580_RS05680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G3580_RS05680	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G3580_RS05685	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
G3580_RS05690	COG0704	Plays a role in the regulation of phosphate uptake
G3580_RS05695	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G3580_RS05705	COG0668	transmembrane transport
G3580_RS05710	COG0589	response to stress
G3580_RS05715	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G3580_RS05730	COG1346	cytolysis
G3580_RS05775	COG4969	Belongs to the N-Me-Phe pilin family
G3580_RS05800	COG3278	Belongs to the heme-copper respiratory oxidase family
G3580_RS05815	COG2010	Cytochrome c
G3580_RS05845	COG3243	poly(R)-hydroxyalkanoic acid synthase
G3580_RS05865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3580_RS05885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3580_RS05890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G3580_RS05910	COG2217	Heavy metal translocating P-type atpase
G3580_RS05925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G3580_RS05945	COG2840	Smr protein MutS2
G3580_RS05950	COG0492	ferredoxin-NADP+ reductase activity
G3580_RS05960	COG1674	ftsk spoiiie
G3580_RS05965	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G3580_RS05970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G3580_RS05980	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G3580_RS05985	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
G3580_RS06000	COG4191	Histidine kinase
G3580_RS06015	COG0477	Major facilitator Superfamily
G3580_RS06035	COG1338	Plays a role in the flagellum-specific transport system
G3580_RS06040	COG3190	flagellar
G3580_RS06055	COG3220	belongs to the UPF0276 family
G3580_RS06070	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
G3580_RS06070	COG3264	Mechanosensitive ion channel
G3580_RS06075	COG0390	transport system, permease component
G3580_RS06100	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G3580_RS06105	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G3580_RS06125	COG1157	protein secretion by the type III secretion system
G3580_RS06135	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G3580_RS06140	COG1766	The M ring may be actively involved in energy transduction
G3580_RS06145	COG3852	Histidine kinase
G3580_RS06155	COG1677	Flagellar hook-basal body complex protein FliE
G3580_RS06170	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G3580_RS06175	COG0312	modulator of DNA gyrase
G3580_RS06180	COG3028	Belongs to the UPF0307 family
G3580_RS06185	COG0521	Mo-molybdopterin cofactor biosynthetic process
G3580_RS06190	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
G3580_RS06195	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G3580_RS06200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G3580_RS06215	COG0191	fructose-bisphosphate aldolase activity
G3580_RS06225	COG3954	Phosphoribulokinase
G3580_RS06230	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
G3580_RS06240	COG4451	ribulose bisphosphate carboxylase, small
G3580_RS06245	COG1850	ribulose-bisphosphate carboxylase activity
G3580_RS06265	COG0525	valine-tRNA ligase activity
G3580_RS06280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G3580_RS06285	COG0795	lipopolysaccharide-transporting ATPase activity
G3580_RS06295	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
G3580_RS06305	COG2943	transferase activity, transferring hexosyl groups
G3580_RS06310	COG0335	large ribosomal subunit rRNA binding
G3580_RS06315	COG0336	Belongs to the RNA methyltransferase TrmD family
G3580_RS06320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G3580_RS06325	COG0228	four-way junction DNA binding
G3580_RS06330	COG0284	orotidine-5'-phosphate decarboxylase activity
G3580_RS06340	COG1295	ribonuclease BN
G3580_RS06355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3580_RS06360	COG1183	phosphatidylcholine synthase activity
G3580_RS06365	COG0688	phosphatidylethanolamine metabolic process
G3580_RS06370	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G3580_RS06375	COG0440	acetolactate synthase activity
G3580_RS06380	COG0028	Belongs to the TPP enzyme family
G3580_RS06405	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
G3580_RS06455	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
G3580_RS06460	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G3580_RS06475	COG1516	flagellar protein fliS
G3580_RS06480	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
G3580_RS06490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G3580_RS06495	COG0438	transferase activity, transferring glycosyl groups
G3580_RS06495	COG1216	Glycosyl transferase, family 2
G3580_RS06505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G3580_RS06560	COG2197	response regulator
G3580_RS06605	COG2258	MOSC domain
G3580_RS06610	COG0583	DNA-binding transcription factor activity
G3580_RS06630	COG0583	DNA-binding transcription factor activity
G3580_RS06635	COG4221	oxidoreductase activity
G3580_RS06660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G3580_RS06665	COG0583	DNA-binding transcription factor activity
G3580_RS06685	COG2070	2-Nitropropane dioxygenase
G3580_RS06695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G3580_RS06700	COG3162	membrane
G3580_RS06725	COG1942	4-Oxalocrotonate Tautomerase
G3580_RS06755	COG3851	Histidine kinase
G3580_RS06760	COG2197	response regulator
G3580_RS06770	COG0626	cystathionine gamma-synthase activity
G3580_RS06775	COG1132	(ABC) transporter
G3580_RS06800	COG0546	phosphoglycolate phosphatase activity
G3580_RS06805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G3580_RS06815	COG0402	S-adenosylhomocysteine deaminase activity
G3580_RS06835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G3580_RS06840	COG0287	Prephenate dehydrogenase
G3580_RS06845	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G3580_RS06855	COG0776	regulation of translation
G3580_RS06865	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G3580_RS06875	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
G3580_RS06915	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G3580_RS06920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G3580_RS06925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G3580_RS06930	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G3580_RS06935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G3580_RS06940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G3580_RS06940	COG0072	phenylalanine-tRNA ligase activity
G3580_RS06945	COG0776	regulation of translation
G3580_RS06980	COG0492	ferredoxin-NADP+ reductase activity
G3580_RS07000	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G3580_RS07005	COG0830	nickel cation binding
G3580_RS07010	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
G3580_RS07015	COG0804	urea catabolic process
G3580_RS07020	COG0832	Belongs to the urease beta subunit family
G3580_RS07025	COG0831	urea catabolic process
G3580_RS07030	COG0829	nickel cation binding
G3580_RS07035	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G3580_RS07045	COG2501	S4 domain
G3580_RS07050	COG0454	-acetyltransferase
G3580_RS07050	COG0456	acetyltransferase
G3580_RS07060	COG4303	Ethanolamine ammonia lyase large subunit
G3580_RS07065	COG4302	ethanolamine ammonia-lyase activity
G3580_RS07130	COG2205	protein histidine kinase activity
G3580_RS07135	COG0745	RESPONSE REGULATOR receiver
G3580_RS07155	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G3580_RS07160	COG0573	inorganic phosphate transmembrane transporter activity
G3580_RS07170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G3580_RS07235	COG3501	Rhs element vgr protein
G3580_RS07260	COG2205	protein histidine kinase activity
G3580_RS07265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G3580_RS07265	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G3580_RS07285	COG2205	protein histidine kinase activity
G3580_RS07285	COG2202	Pas domain
G3580_RS07310	COG0302	gtp cyclohydrolase
G3580_RS07350	COG4772	TonB-dependent receptor
G3580_RS07365	COG0714	Associated with various cellular activities
G3580_RS07370	COG2425	protein containing a von Willebrand factor type A (vWA) domain
G3580_RS07390	COG0348	domain, Protein
G3580_RS07390	COG3901	Regulator of nitric oxide reductase transcription
G3580_RS07395	COG2197	response regulator
G3580_RS07400	COG3851	Histidine kinase
G3580_RS07455	COG3284	Transcriptional regulator
G3580_RS07465	COG1012	belongs to the aldehyde dehydrogenase family
G3580_RS07480	COG4993	Dehydrogenase
G3580_RS07480	COG2010	Cytochrome c
G3580_RS07485	COG3284	Transcriptional regulator
G3580_RS07520	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G3580_RS07525	COG0248	Ppx GppA phosphatase
G3580_RS07530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G3580_RS07535	COG1127	ABC transporter
G3580_RS07550	COG0318	PFAM AMP-dependent synthetase and ligase
G3580_RS07560	COG0084	hydrolase, TatD family'
G3580_RS07585	COG1960	acyl-CoA dehydrogenase activity
G3580_RS07590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G3580_RS07600	COG2350	Protein conserved in bacteria
G3580_RS07605	COG2917	probably involved in intracellular septation
G3580_RS07620	COG2205	protein histidine kinase activity
G3580_RS07625	COG0745	RESPONSE REGULATOR receiver
G3580_RS07635	COG1214	PFAM Peptidase M22, glycoprotease
G3580_RS07640	COG0456	acetyltransferase
G3580_RS07645	COG1573	uracil-dna glycosylase
G3580_RS07665	COG0477	Major facilitator Superfamily
G3580_RS07670	COG0583	DNA-binding transcription factor activity
G3580_RS07710	COG0583	DNA-binding transcription factor activity
G3580_RS07725	COG0535	radical SAM domain protein
G3580_RS07740	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G3580_RS07755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G3580_RS07775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G3580_RS07780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
G3580_RS07785	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G3580_RS07790	COG1522	sequence-specific DNA binding
G3580_RS07800	COG1960	acyl-CoA dehydrogenase activity
G3580_RS07805	COG0583	DNA-binding transcription factor activity
G3580_RS07815	COG1335	isochorismatase
G3580_RS07825	COG0579	oxidoreductase
G3580_RS07840	COG0840	transmembrane signaling receptor activity
G3580_RS07855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G3580_RS07885	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
G3580_RS07920	COG0210	DNA helicase
G3580_RS07960	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G3580_RS07960	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G3580_RS07965	COG0509	glycine decarboxylation via glycine cleavage system
G3580_RS07970	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G3580_RS07980	COG0613	PHP domain protein
G3580_RS07985	COG0009	L-threonylcarbamoyladenylate synthase
G3580_RS07990	COG1994	Peptidase M50
G3580_RS07995	COG0180	Tryptophanyl-tRNA synthetase
G3580_RS08000	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G3580_RS08005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G3580_RS08015	COG0779	Required for maturation of 30S ribosomal subunits
G3580_RS08020	COG0195	Participates in both transcription termination and antitermination
G3580_RS08020	COG2251	uridine kinase activity
G3580_RS08025	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G3580_RS08030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G3580_RS08035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G3580_RS08040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G3580_RS08045	COG1185	polyribonucleotide nucleotidyltransferase activity
G3580_RS08050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G3580_RS08155	COG1222	aaa ATPase
G3580_RS08265	COG4569	acetaldehyde dehydrogenase (acetylating) activity
G3580_RS08270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3580_RS08315	COG2909	trisaccharide binding
G3580_RS08340	COG2264	protein methyltransferase activity
G3580_RS08355	COG0318	PFAM AMP-dependent synthetase and ligase
G3580_RS08365	COG0659	secondary active sulfate transmembrane transporter activity
G3580_RS08370	COG1763	Mo-molybdopterin cofactor biosynthetic process
G3580_RS08375	COG0303	'Molybdopterin
G3580_RS08380	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
G3580_RS08385	COG0314	molybdopterin synthase activity
G3580_RS08395	COG0542	response to heat
G3580_RS08430	COG1404	Belongs to the peptidase S8 family
G3580_RS08450	COG0348	domain, Protein
G3580_RS08460	COG0583	DNA-binding transcription factor activity
G3580_RS08465	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G3580_RS08470	COG0438	transferase activity, transferring glycosyl groups
G3580_RS08480	COG1881	PFAM PEBP family protein
G3580_RS08500	COG2095	MarC family integral membrane protein
G3580_RS08505	COG0840	transmembrane signaling receptor activity
G3580_RS08510	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3580_RS08510	COG1902	pentaerythritol trinitrate reductase activity
G3580_RS08540	COG0625	glutathione transferase activity
G3580_RS08555	COG1278	Cold shock
G3580_RS08565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G3580_RS08570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G3580_RS08575	COG0149	triose-phosphate isomerase activity
G3580_RS08590	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G3580_RS08595	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G3580_RS08600	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G3580_RS08605	COG0649	NAD binding
G3580_RS08610	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
G3580_RS08620	COG1034	ATP synthesis coupled electron transport
G3580_RS08625	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G3580_RS08630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G3580_RS08640	COG0713	ATP synthesis coupled electron transport
G3580_RS08655	COG1007	ATP synthesis coupled electron transport
G3580_RS08660	COG0494	nUDIX hydrolase
G3580_RS08665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G3580_RS08680	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G3580_RS08685	COG3383	formate dehydrogenase (NAD+) activity
G3580_RS08690	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
G3580_RS08695	COG3259	Nickel-dependent hydrogenase
G3580_RS08745	COG0326	Molecular chaperone. Has ATPase activity
G3580_RS08755	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3580_RS08765	COG0039	L-malate dehydrogenase activity
G3580_RS08770	COG2188	Transcriptional regulator
G3580_RS08785	COG1053	succinate dehydrogenase
G3580_RS08790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G3580_RS08795	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G3580_RS08800	COG0372	Belongs to the citrate synthase family
G3580_RS08805	COG0567	Dehydrogenase, E1 component
G3580_RS08810	COG0508	dehydrogenase complex catalyzes the overall conversion of
G3580_RS08815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G3580_RS08820	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G3580_RS08830	COG1199	ATP-dependent helicase activity
G3580_RS08835	COG1473	amidohydrolase
G3580_RS08840	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G3580_RS08850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G3580_RS08870	COG0556	nucleotide-excision repair
G3580_RS08875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G3580_RS08880	COG1530	ribonuclease E activity
G3580_RS08885	COG0564	pseudouridine synthase activity
G3580_RS08905	COG0424	maF-like protein
G3580_RS08910	COG1399	metal-binding, possibly nucleic acid-binding protein
G3580_RS08915	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G3580_RS08920	COG0416	fatty acid biosynthetic process
G3580_RS08925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G3580_RS08930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G3580_RS08940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G3580_RS08945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G3580_RS08955	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G3580_RS08980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G3580_RS08990	COG0481	GTPase activity
G3580_RS08995	COG0681	Belongs to the peptidase S26 family
G3580_RS09005	COG0571	ribonuclease III activity
G3580_RS09010	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G3580_RS09015	COG1381	Involved in DNA repair and RecF pathway recombination
G3580_RS09020	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G3580_RS09025	COG0736	holo-[acyl-carrier-protein] synthase activity
G3580_RS09030	COG1472	Belongs to the glycosyl hydrolase 3 family
G3580_RS09040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G3580_RS09075	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G3580_RS09085	COG0850	regulation of cytokinetic process
G3580_RS09090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G3580_RS09095	COG1393	Belongs to the ArsC family
G3580_RS09100	COG2183	response to ionizing radiation
G3580_RS09115	COG2818	Glycosylase
G3580_RS09120	COG0045	succinate-CoA ligase (ADP-forming) activity
G3580_RS09120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G3580_RS09120	COG1042	CoA-binding domain protein
G3580_RS09125	COG2205	protein histidine kinase activity
G3580_RS09140	COG2329	Antibiotic biosynthesis monooxygenase
G3580_RS09145	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
G3580_RS09160	COG4181	ATPase activity
G3580_RS09165	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
G3580_RS09190	COG2719	SpoVR family
G3580_RS09195	COG2718	Belongs to the UPF0229 family
G3580_RS09200	COG2766	serine protein kinase
G3580_RS09205	COG0544	peptidyl-prolyl cis-trans isomerase activity
G3580_RS09210	COG0740	serine-type endopeptidase activity
G3580_RS09215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G3580_RS09220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G3580_RS09240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G3580_RS09250	COG0747	negative chemotaxis
G3580_RS09255	COG0601	transmembrane transport
G3580_RS09260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G3580_RS09285	COG1355	regulation of microtubule-based process
G3580_RS09295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G3580_RS09300	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G3580_RS09315	COG0655	NAD(P)H dehydrogenase (quinone) activity
G3580_RS09320	COG3228	Belongs to the MtfA family
G3580_RS09325	COG0697	spore germination
G3580_RS09330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G3580_RS09340	COG0745	RESPONSE REGULATOR receiver
G3580_RS09355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G3580_RS09355	COG0426	domain, Protein
G3580_RS09380	COG0732	type I restriction modification DNA specificity domain
G3580_RS09415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3580_RS09425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3580_RS09425	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G3580_RS09435	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G3580_RS09440	COG3706	GGDEF domain
G3580_RS09445	COG1196	nuclear chromosome segregation
G3580_RS09465	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G3580_RS09495	COG1136	(ABC) transporter
G3580_RS09500	COG0840	transmembrane signaling receptor activity
G3580_RS09530	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G3580_RS09540	COG0739	heme binding
G3580_RS09560	COG0330	HflC and HflK could
G3580_RS09565	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G3580_RS09575	COG0463	Glycosyl transferase, family 2
G3580_RS09585	COG0671	phosphoesterase, PA-phosphatase related
G3580_RS09590	COG0047	phosphoribosylformylglycinamidine synthase activity
G3580_RS09590	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G3580_RS09610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G3580_RS09620	COG0504	CTP synthase activity
G3580_RS09625	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G3580_RS09630	COG0148	phosphopyruvate hydratase activity
G3580_RS09635	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G3580_RS09640	COG0517	IMP dehydrogenase activity
G3580_RS09640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G3580_RS09640	COG0617	tRNA 3'-terminal CCA addition
G3580_RS09645	COG0791	NLP P60 protein
G3580_RS09650	COG1490	D-aminoacyl-tRNA deacylase activity
G3580_RS09685	COG1024	Enoyl-CoA hydratase
G3580_RS09705	COG2081	HI0933 family
G3580_RS09715	COG2154	pterin-4-alpha-carbinolamine dehydratase
G3580_RS09740	COG1192	Involved in chromosome partitioning
G3580_RS09760	COG3608	succinylglutamate desuccinylase aspartoacylase
G3580_RS09760	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G3580_RS09785	COG1538	Outer membrane efflux protein
G3580_RS09810	COG2205	protein histidine kinase activity
G3580_RS09815	COG2132	Multicopper oxidase
G3580_RS09865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G3580_RS09870	COG0785	Cytochrome C biogenesis protein
G3580_RS09885	COG2828	Protein conserved in bacteria
G3580_RS09890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3580_RS09910	COG0583	DNA-binding transcription factor activity
G3580_RS09925	COG2301	Belongs to the HpcH HpaI aldolase family
G3580_RS09930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3580_RS09935	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
G3580_RS09955	COG2828	Protein conserved in bacteria
G3580_RS09960	COG0583	DNA-binding transcription factor activity
G3580_RS09970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G3580_RS09975	COG3383	formate dehydrogenase (NAD+) activity
G3580_RS10000	COG3284	Transcriptional regulator
G3580_RS10010	COG0084	hydrolase, TatD family'
G3580_RS10025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G3580_RS10030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G3580_RS10035	COG0354	folic acid binding
G3580_RS10065	COG2205	protein histidine kinase activity
G3580_RS10065	COG2202	Pas domain
G3580_RS10085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G3580_RS10085	COG0519	Catalyzes the synthesis of GMP from XMP
G3580_RS10100	COG2914	Belongs to the UPF0125 (RnfH) family
G3580_RS10105	COG2867	negative regulation of translational initiation
G3580_RS10110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G3580_RS10115	COG4191	Histidine kinase
G3580_RS10120	COG2204	response regulator
G3580_RS10125	COG2358	TRAP transporter, solute receptor (TAXI family
G3580_RS10135	COG2814	Major facilitator Superfamily
G3580_RS10140	COG1566	PFAM secretion protein HlyD family protein
G3580_RS10145	COG1846	Transcriptional regulator
G3580_RS10160	COG0587	DNA-directed DNA polymerase activity
G3580_RS10165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G3580_RS10180	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G3580_RS10185	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G3580_RS10190	COG0560	Phosphoserine phosphatase
G3580_RS10205	COG3384	dioxygenase
G3580_RS10210	COG3038	cytochrome b561
G3580_RS10220	COG2353	YceI-like domain
G3580_RS10225	COG0435	Glutathione S-transferase
G3580_RS10250	COG2204	response regulator
G3580_RS10260	COG2205	protein histidine kinase activity
G3580_RS10285	COG5001	Diguanylate cyclase
G3580_RS10285	COG5002	protein histidine kinase activity
G3580_RS10300	COG0778	Nitroreductase
G3580_RS10305	COG3045	CreA protein
G3580_RS10310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G3580_RS10315	COG2133	pyrroloquinoline quinone binding
G3580_RS10325	COG4625	pathogenesis
G3580_RS10330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G3580_RS10345	COG2900	Belongs to the SlyX family
G3580_RS10355	COG2866	Carboxypeptidase
G3580_RS10360	COG3022	response to hydroperoxide
G3580_RS10370	COG0156	8-amino-7-oxononanoate synthase activity
G3580_RS10375	COG2267	carboxylic ester hydrolase activity
G3580_RS10380	COG2226	methyltransferase
G3580_RS10385	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G3580_RS10390	COG0659	secondary active sulfate transmembrane transporter activity
G3580_RS10400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G3580_RS10405	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G3580_RS10410	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3580_RS10415	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3580_RS10420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G3580_RS10425	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3580_RS10445	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G3580_RS10450	COG0575	Belongs to the CDS family
G3580_RS10455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G3580_RS10460	COG0233	cytoplasmic translational termination
G3580_RS10465	COG0528	UMP kinase activity
G3580_RS10470	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G3580_RS10475	COG0052	Belongs to the universal ribosomal protein uS2 family
G3580_RS10480	COG0024	Methionine aminopeptidase
G3580_RS10485	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G3580_RS10505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G3580_RS10515	COG1196	nuclear chromosome segregation
G3580_RS10525	COG2171	N-acyltransferase activity
G3580_RS10535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3580_RS10540	COG2890	protein-(glutamine-N5) methyltransferase activity
G3580_RS10545	COG0840	transmembrane signaling receptor activity
G3580_RS10550	COG0784	Response regulator, receiver
G3580_RS10565	COG0443	Heat shock 70 kDa protein
G3580_RS10570	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
G3580_RS10575	COG0316	Belongs to the HesB IscA family
G3580_RS10580	COG0822	iron-sulfur transferase activity
G3580_RS10585	COG1104	cysteine desulfurase activity
G3580_RS10590	COG1104	cysteine desulfurase activity
G3580_RS10600	COG1045	serine acetyltransferase
G3580_RS10615	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G3580_RS10625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G3580_RS10630	COG0328	RNA-DNA hybrid ribonuclease activity
G3580_RS10635	COG2226	methyltransferase
G3580_RS10640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3580_RS10645	COG3706	GGDEF domain
G3580_RS10645	COG2203	Gaf domain
G3580_RS10645	COG5001	Diguanylate cyclase
G3580_RS10645	COG4251	negative regulation of phosphorylation
G3580_RS10650	COG0741	lytic transglycosylase activity
G3580_RS10650	COG1388	LysM domain
G3580_RS10660	COG1047	Peptidyl-prolyl cis-trans
G3580_RS10670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G3580_RS10700	COG0277	FAD linked oxidase domain protein
G3580_RS10705	COG1752	Esterase of the alpha-beta hydrolase superfamily
G3580_RS10710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G3580_RS10715	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
G3580_RS10725	COG1028	Short-chain dehydrogenase reductase Sdr
G3580_RS10730	COG3243	poly(R)-hydroxyalkanoic acid synthase
G3580_RS10745	COG0564	pseudouridine synthase activity
G3580_RS10760	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
G3580_RS10760	COG0662	Cupin 2, conserved barrel domain protein
G3580_RS10795	COG0720	synthase
G3580_RS10800	COG2308	Evidence 4 Homologs of previously reported genes of
G3580_RS10815	COG2308	Evidence 4 Homologs of previously reported genes of
G3580_RS10815	COG2307	Protein conserved in bacteria
G3580_RS10840	COG0617	tRNA 3'-terminal CCA addition
G3580_RS10840	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G3580_RS10840	COG0517	IMP dehydrogenase activity
G3580_RS10850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G3580_RS10855	COG2850	peptidyl-arginine hydroxylation
G3580_RS10870	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G3580_RS10875	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
G3580_RS10880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3580_RS10890	COG0714	Associated with various cellular activities
G3580_RS10920	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G3580_RS10925	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G3580_RS10970	COG0069	glutamate synthase activity
G3580_RS11000	COG0436	Aminotransferase
G3580_RS11010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G3580_RS11015	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G3580_RS11035	COG0791	NLP P60 protein
G3580_RS11045	COG1840	ABC-type Fe3 transport system, periplasmic component
G3580_RS11050	COG1178	ABC-type Fe3 transport system permease component
G3580_RS11055	COG3842	ATPase activity
G3580_RS11060	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G3580_RS11065	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G3580_RS11070	COG0167	dihydroorotate dehydrogenase activity
G3580_RS11075	COG4657	Part of a membrane complex involved in electron transport
G3580_RS11080	COG2878	Part of a membrane complex involved in electron transport
G3580_RS11085	COG4656	Part of a membrane complex involved in electron transport
G3580_RS11095	COG4659	FMN binding
G3580_RS11100	COG4660	Part of a membrane complex involved in electron transport
G3580_RS11105	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G3580_RS11135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3580_RS11150	COG3240	lipase activity
G3580_RS11155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G3580_RS11185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G3580_RS11190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
G3580_RS11205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G3580_RS11210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G3580_RS11215	COG0505	Belongs to the CarA family
G3580_RS11220	COG5002	protein histidine kinase activity
G3580_RS11220	COG2205	protein histidine kinase activity
G3580_RS11220	COG0784	Response regulator, receiver
G3580_RS11225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G3580_RS11230	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G3580_RS11235	COG0735	belongs to the Fur family
G3580_RS11245	COG0497	DNA recombination
G3580_RS11250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G3580_RS11255	COG1420	regulation of RNA biosynthetic process
G3580_RS11260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G3580_RS11280	COG0515	serine threonine protein kinase
G3580_RS11280	COG2815	serine threonine protein kinase
G3580_RS11285	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G3580_RS11290	COG0443	Heat shock 70 kDa protein
G3580_RS11295	COG0484	heat shock protein binding
G3580_RS11310	COG0215	cysteine-tRNA ligase activity
G3580_RS11325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G3580_RS11330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G3580_RS11335	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3580_RS11360	COG0285	dihydrofolate synthase activity
G3580_RS11365	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G3580_RS11370	COG0159	tryptophan synthase activity
G3580_RS11375	COG0133	tryptophan synthase activity
G3580_RS11380	COG0135	phosphoribosylanthranilate isomerase activity
G3580_RS11385	COG0101	tRNA pseudouridine synthase activity
G3580_RS11390	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G3580_RS11405	COG0473	3-isopropylmalate dehydrogenase activity
G3580_RS11410	COG0066	3-isopropylmalate dehydratase activity
G3580_RS11415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G3580_RS11425	COG2814	Major facilitator Superfamily
G3580_RS11435	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G3580_RS11440	COG0440	acetolactate synthase activity
G3580_RS11445	COG0028	Belongs to the TPP enzyme family
G3580_RS11450	COG0318	PFAM AMP-dependent synthetase and ligase
G3580_RS11455	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G3580_RS11455	COG0617	tRNA 3'-terminal CCA addition
G3580_RS11455	COG0517	IMP dehydrogenase activity
G3580_RS11460	COG1074	ATP-dependent DNA helicase activity
G3580_RS11465	COG2887	Belongs to the helicase family. UvrD subfamily
G3580_RS11470	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G3580_RS11480	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G3580_RS11500	COG0583	DNA-binding transcription factor activity
G3580_RS11505	COG2814	Major facilitator Superfamily
G3580_RS11515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G3580_RS11545	COG0727	PFAM Uncharacterised protein family (UPF0153)
G3580_RS11560	COG3012	SEC-C Motif Domain Protein
G3580_RS11560	COG3318	Belongs to the UPF0149 family
G3580_RS11580	COG0254	rRNA binding
G3580_RS11590	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G3580_RS11595	COG0501	Belongs to the peptidase M48B family
G3580_RS11605	COG1162	GTPase activity
G3580_RS11610	COG0183	Belongs to the thiolase family
G3580_RS11635	COG1666	GTP binding
G3580_RS11640	COG3123	guanosine phosphorylase activity
G3580_RS11650	COG0137	argininosuccinate synthase activity
G3580_RS11655	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G3580_RS11660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G3580_RS11670	COG0268	Binds directly to 16S ribosomal RNA
G3580_RS11675	COG0728	peptidoglycan biosynthetic process
G3580_RS11680	COG1881	PFAM PEBP family protein
G3580_RS11685	COG0405	Gamma-glutamyltransferase
G3580_RS11695	COG0563	adenylate kinase activity
G3580_RS11700	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G3580_RS11705	COG2835	tetraacyldisaccharide 4'-kinase activity
G3580_RS11710	COG1663	tetraacyldisaccharide 4'-kinase activity
G3580_RS11715	COG0848	biopolymer transport protein
G3580_RS11720	COG0811	peptide transport
G3580_RS11725	COG1570	exodeoxyribonuclease VII activity
G3580_RS11730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G3580_RS11735	COG1595	DNA-templated transcription, initiation
G3580_RS11775	COG2203	Gaf domain
G3580_RS11775	COG3706	GGDEF domain
G3580_RS11775	COG4251	negative regulation of phosphorylation
G3580_RS11775	COG5001	Diguanylate cyclase
G3580_RS11780	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G3580_RS11790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G3580_RS11795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G3580_RS11825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G3580_RS11835	COG0643	Histidine kinase
G3580_RS11835	COG0784	Response regulator, receiver
G3580_RS11835	COG2198	Histidine kinase
G3580_RS11840	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
G3580_RS11845	COG0745	RESPONSE REGULATOR receiver
G3580_RS11850	COG0784	Response regulator, receiver
G3580_RS11850	COG0835	chemotaxis
G3580_RS11855	COG0784	Response regulator, receiver
G3580_RS11855	COG0835	chemotaxis
G3580_RS11870	COG2201	protein-glutamate methylesterase activity
G3580_RS11875	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
G3580_RS11895	COG0835	chemotaxis
G3580_RS11900	COG2198	Histidine kinase
G3580_RS11900	COG0643	Histidine kinase
G3580_RS11905	COG0745	RESPONSE REGULATOR receiver
G3580_RS11910	COG0840	transmembrane signaling receptor activity
G3580_RS11915	COG1360	Flagellar Motor Protein
G3580_RS11920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G3580_RS11985	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G3580_RS11995	COG0586	Pfam SNARE associated Golgi protein
G3580_RS12000	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G3580_RS12010	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G3580_RS12030	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
G3580_RS12050	COG1216	Glycosyl transferase, family 2
G3580_RS12075	COG0642	Histidine kinase
G3580_RS12090	COG0842	Transport permease protein
G3580_RS12095	COG1131	(ABC) transporter
G3580_RS12125	COG1294	oxidase, subunit
G3580_RS12145	COG0425	Belongs to the sulfur carrier protein TusA family
G3580_RS12155	COG0315	cyclic pyranopterin monophosphate synthase activity
G3580_RS12160	COG3025	triphosphatase activity
G3580_RS12180	COG0482	sulfurtransferase activity
G3580_RS12210	COG0429	hydrolase of the alpha beta-hydrolase fold
G3580_RS12235	COG0745	RESPONSE REGULATOR receiver
G3580_RS12240	COG0583	DNA-binding transcription factor activity
G3580_RS12245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G3580_RS12250	COG3002	Belongs to the UPF0753 family
G3580_RS12265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G3580_RS12275	COG2096	Adenosyltransferase
G3580_RS12295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G3580_RS12310	COG0577	efflux transmembrane transporter activity
G3580_RS12310	COG1136	(ABC) transporter
G3580_RS12325	COG1028	Short-chain dehydrogenase reductase Sdr
G3580_RS12355	COG2072	flavoprotein involved in K transport
G3580_RS12375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G3580_RS12380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G3580_RS12385	COG0583	DNA-binding transcription factor activity
G3580_RS12395	COG1741	Belongs to the pirin family
G3580_RS12405	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
G3580_RS12420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G3580_RS12430	COG3951	Flagellar rod assembly protein muramidase FlgJ
G3580_RS12430	COG1705	Flagellar rod assembly protein muramidase FlgJ
G3580_RS12435	COG1706	bacterial-type flagellum-dependent cell motility
G3580_RS12440	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
G3580_RS12450	COG4787	bacterial-type flagellum-dependent cell motility
G3580_RS12455	COG1749	Flagellar hook protein flgE
G3580_RS12460	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G3580_RS12470	COG1815	bacterial-type flagellum-dependent cell motility
G3580_RS12490	COG1418	mRNA catabolic process
G3580_RS12500	COG4456	Virulence-associated protein
G3580_RS12520	COG2703	oxygen carrier activity
G3580_RS12530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G3580_RS12555	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G3580_RS12595	COG0359	binds to the 23S rRNA
G3580_RS12600	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G3580_RS12610	COG0360	Binds together with S18 to 16S ribosomal RNA
G3580_RS12620	COG1160	GTP binding
G3580_RS12630	COG2205	protein histidine kinase activity
G3580_RS12630	COG0784	Response regulator, receiver
G3580_RS12630	COG2198	Histidine kinase
G3580_RS12640	COG3706	GGDEF domain
G3580_RS12660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G3580_RS12670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3580_RS12675	COG2188	Transcriptional regulator
G3580_RS12680	COG3618	amidohydrolase
G3580_RS12695	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G3580_RS12715	COG0535	radical SAM domain protein
G3580_RS12720	COG2703	oxygen carrier activity
G3580_RS12760	COG3217	Mosc domain protein beta barrel domain protein
G3580_RS12760	COG0633	Ferredoxin
G3580_RS12765	COG2207	Transcriptional regulator
G3580_RS12815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G3580_RS12820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G3580_RS12835	COG3046	protein related to deoxyribodipyrimidine photolyase
G3580_RS12845	COG0415	Belongs to the DNA photolyase family
G3580_RS12885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3580_RS12895	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G3580_RS12900	COG0628	permease
G3580_RS12915	COG0617	tRNA 3'-terminal CCA addition
G3580_RS12920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G3580_RS12925	COG1428	Deoxynucleoside kinase
G3580_RS12930	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G3580_RS12935	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G3580_RS12945	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
G3580_RS12955	COG0745	RESPONSE REGULATOR receiver
G3580_RS12980	COG0583	DNA-binding transcription factor activity
G3580_RS13005	COG2824	Alkylphosphonate utilization operon protein PhnA
G3580_RS13010	COG4106	trans-aconitate 2-methyltransferase activity
G3580_RS13015	COG0583	DNA-binding transcription factor activity
G3580_RS13060	COG1944	ATP diphosphatase activity
G3580_RS13065	COG0308	aminopeptidase N
G3580_RS13070	COG1592	Rubrerythrin
G3580_RS13075	COG0247	lactate metabolic process
G3580_RS13100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G3580_RS13105	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G3580_RS13110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G3580_RS13110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G3580_RS13115	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G3580_RS13125	COG0793	Belongs to the peptidase S41A family
G3580_RS13135	COG0588	phosphoglycerate mutase activity
G3580_RS13145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G3580_RS13150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G3580_RS13155	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G3580_RS13165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G3580_RS13170	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G3580_RS13175	COG1040	competence protein
G3580_RS13180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G3580_RS13185	COG2226	methyltransferase
G3580_RS13205	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G3580_RS13215	COG2833	Protein of unknown function (DUF455)
G3580_RS13220	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G3580_RS13230	COG4536	flavin adenine dinucleotide binding
G3580_RS13245	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G3580_RS13260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G3580_RS13280	COG0494	nUDIX hydrolase
G3580_RS13285	COG0071	Belongs to the small heat shock protein (HSP20) family
G3580_RS13295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G3580_RS13310	COG0318	PFAM AMP-dependent synthetase and ligase
G3580_RS13320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G3580_RS13365	COG0175	sulfate reduction
G3580_RS13370	COG1218	3'(2'),5'-bisphosphate nucleotidase
G3580_RS13375	COG0490	domain, Protein
G3580_RS13375	COG0471	metal ion transport
G3580_RS13415	COG0438	transferase activity, transferring glycosyl groups
G3580_RS13425	COG0367	asparagine synthase
G3580_RS13460	COG3409	Peptidoglycan-binding domain 1 protein
G3580_RS13460	COG3267	Type II secretory pathway component ExeA
G3580_RS13470	COG0489	protein tyrosine kinase activity
G3580_RS13495	COG1136	(ABC) transporter
G3580_RS13515	COG0506	proline dehydrogenase activity
G3580_RS13515	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G3580_RS13515	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G3580_RS13525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3580_RS13530	COG2703	oxygen carrier activity
G3580_RS13535	COG0438	transferase activity, transferring glycosyl groups
G3580_RS13540	COG2969	positive regulation of protein catabolic process
G3580_RS13545	COG0625	glutathione transferase activity
G3580_RS13550	COG2857	Cytochrome c1
G3580_RS13555	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G3580_RS13560	COG0723	plastoquinol--plastocyanin reductase activity
G3580_RS13565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3580_RS13570	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G3580_RS13575	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G3580_RS13580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G3580_RS13595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G3580_RS13600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G3580_RS13605	COG0557	exoribonuclease II activity
G3580_RS13620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G3580_RS13625	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G3580_RS13635	COG0330	HflC and HflK could
G3580_RS13640	COG0330	HflC and HflK could
G3580_RS13645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G3580_RS13650	COG1923	regulation of RNA biosynthetic process
G3580_RS13655	COG1160	GTP binding
G3580_RS13670	COG0124	histidyl-tRNA synthetase
G3580_RS13675	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G3580_RS13690	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G3580_RS13695	COG0105	UTP biosynthetic process
G3580_RS13710	COG4566	intracellular signal transduction
G3580_RS13720	COG0825	malonyl-CoA metabolic process
G3580_RS13730	COG0009	L-threonylcarbamoyladenylate synthase
G3580_RS13735	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G3580_RS13740	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G3580_RS13745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G3580_RS13750	COG4566	intracellular signal transduction
G3580_RS13765	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G3580_RS13770	COG0508	dehydrogenase complex catalyzes the overall conversion of
G3580_RS13775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G3580_RS13805	COG1252	NADH dehydrogenase
G3580_RS13810	COG1297	OPT oligopeptide transporter protein
G3580_RS13820	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
G3580_RS13825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G3580_RS13830	COG2199	diguanylate cyclase activity
G3580_RS13845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G3580_RS13870	COG2414	aldehyde ferredoxin oxidoreductase
G3580_RS13875	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
G3580_RS13900	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
G3580_RS13910	COG2391	methyltransferase activity
G3580_RS13930	COG2010	Cytochrome c
G3580_RS13960	COG0640	Transcriptional regulator
G3580_RS13970	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3580_RS13985	COG0756	dUTP diphosphatase activity
G3580_RS13990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G3580_RS13995	COG2003	Belongs to the UPF0758 family
G3580_RS14000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G3580_RS14010	COG1278	Cold shock
G3580_RS14015	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G3580_RS14020	COG0542	response to heat
G3580_RS14025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G3580_RS14035	COG4251	negative regulation of phosphorylation
G3580_RS14035	COG5001	Diguanylate cyclase
G3580_RS14035	COG2203	Gaf domain
G3580_RS14035	COG3706	GGDEF domain
G3580_RS14050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G3580_RS14055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G3580_RS14065	COG0484	heat shock protein binding
G3580_RS14085	COG3706	GGDEF domain
G3580_RS14090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G3580_RS14115	COG5001	Diguanylate cyclase
G3580_RS14115	COG5002	protein histidine kinase activity
G3580_RS14120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G3580_RS14125	COG0581	inorganic phosphate transmembrane transporter activity
G3580_RS14140	COG0697	spore germination
G3580_RS14160	COG0133	tryptophan synthase activity
G3580_RS14165	COG4628	conserved protein (DUF2132)
G3580_RS14170	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G3580_RS14180	COG0802	atpase or kinase
G3580_RS14185	COG0860	N-Acetylmuramoyl-L-alanine amidase
G3580_RS14190	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
G3580_RS14195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G3580_RS14200	COG0196	riboflavin kinase activity
G3580_RS14205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G3580_RS14210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G3580_RS14215	COG1047	Peptidyl-prolyl cis-trans
G3580_RS14220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G3580_RS14230	COG1722	exodeoxyribonuclease VII activity
G3580_RS14235	COG0142	geranyltranstransferase activity
G3580_RS14240	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G3580_RS14245	COG1469	GTP cyclohydrolase I activity
G3580_RS14280	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G3580_RS14285	COG0739	heme binding
G3580_RS14290	COG0316	Belongs to the HesB IscA family
G3580_RS14295	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G3580_RS14300	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G3580_RS14305	COG1765	OsmC-like protein
G3580_RS14310	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
G3580_RS14320	COG0494	nUDIX hydrolase
G3580_RS14325	COG0442	prolyl-tRNA aminoacylation
G3580_RS14330	COG0741	lytic transglycosylase activity
G3580_RS14350	COG0312	modulator of DNA gyrase
G3580_RS14365	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G3580_RS14375	COG0142	geranyltranstransferase activity
G3580_RS14385	COG1653	transport
G3580_RS14395	COG3300	MHYT domain
G3580_RS14395	COG5001	Diguanylate cyclase
G3580_RS14405	COG0667	Aldo Keto reductase
G3580_RS14410	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
G3580_RS14415	COG0513	Belongs to the DEAD box helicase family
G3580_RS14430	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
G3580_RS14440	COG0631	protein serine/threonine phosphatase activity
G3580_RS14445	COG1418	mRNA catabolic process
G3580_RS14445	COG2433	Pfam Transposase IS66
G3580_RS14450	COG0247	lactate metabolic process
G3580_RS14455	COG0277	FAD linked oxidase domain protein
G3580_RS14460	COG0277	FAD linked oxidase domain protein
G3580_RS14465	COG2186	Transcriptional regulator
G3580_RS14475	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G3580_RS14480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G3580_RS14485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G3580_RS14490	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G3580_RS14515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G3580_RS14535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G3580_RS14540	COG0745	RESPONSE REGULATOR receiver
G3580_RS14545	COG0604	alcohol dehydrogenase
G3580_RS14555	COG1704	LemA family
G3580_RS14575	COG0840	transmembrane signaling receptor activity
G3580_RS14585	COG0741	lytic transglycosylase activity
G3580_RS14600	COG2204	response regulator
G3580_RS14605	COG4191	Histidine kinase
G3580_RS14610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G3580_RS14630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G3580_RS14635	COG0343	queuine tRNA-ribosyltransferase activity
G3580_RS14640	COG1862	Preprotein translocase
G3580_RS14645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G3580_RS14680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G3580_RS14685	COG1234	tRNA 3'-trailer cleavage
G3580_RS14690	COG1716	ATPase activity
G3580_RS14695	COG0631	protein serine/threonine phosphatase activity
G3580_RS14700	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G3580_RS14705	COG0045	succinate-CoA ligase (ADP-forming) activity
G3580_RS14725	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G3580_RS14735	COG0805	protein transport
G3580_RS14740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G3580_RS14745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G3580_RS14755	COG0140	phosphoribosyl-ATP diphosphatase activity
G3580_RS14760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G3580_RS14765	COG0107	imidazoleglycerol-phosphate synthase activity
G3580_RS14770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G3580_RS14775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G3580_RS14780	COG0131	Imidazoleglycerol-phosphate dehydratase
G3580_RS14785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G3580_RS14790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G3580_RS14795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G3580_RS14800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G3580_RS14805	COG0271	Belongs to the BolA IbaG family
G3580_RS14810	COG0842	Transport permease protein
G3580_RS14815	COG1131	(ABC) transporter
G3580_RS14830	COG2853	Lipoprotein
G3580_RS14835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G3580_RS14840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G3580_RS14845	COG1127	ABC transporter
G3580_RS14860	COG4796	Type ii and iii secretion system protein
G3580_RS14900	COG2165	general secretion pathway protein
G3580_RS14935	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
G3580_RS14940	COG1024	Enoyl-CoA hydratase
G3580_RS14950	COG0204	Acyl-transferase
G3580_RS14955	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
G3580_RS14960	COG0751	glycine-tRNA ligase activity
G3580_RS14965	COG0752	glycyl-tRNA synthetase alpha subunit
G3580_RS14975	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G3580_RS14980	COG4535	Mg2 and Co2 transporter CorC
G3580_RS14985	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G3580_RS14990	COG1702	phosphate starvation-inducible protein PhoH
G3580_RS14995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G3580_RS15010	COG3093	addiction module antidote protein HigA
G3580_RS15020	COG1309	transcriptional regulator
G3580_RS15025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3580_RS15030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3580_RS15040	COG2116	formate transmembrane transporter activity
G3580_RS15045	COG0515	serine threonine protein kinase
G3580_RS15045	COG2815	serine threonine protein kinase
G3580_RS15055	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G3580_RS15060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G3580_RS15060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G3580_RS15065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G3580_RS15075	COG1999	signal sequence binding
G3580_RS15085	COG3128	pkhd-type hydroxylase
G3580_RS15095	COG4774	siderophore transport
G3580_RS15100	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G3580_RS15105	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G3580_RS15115	COG0356	it plays a direct role in the translocation of protons across the membrane
G3580_RS15125	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G3580_RS15125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G3580_RS15130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G3580_RS15140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G3580_RS15160	COG2862	Uncharacterized protein family, UPF0114
G3580_RS15185	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G3580_RS15195	COG3634	alkyl hydroperoxide reductase activity
G3580_RS15205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3580_RS15210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G3580_RS15220	COG0004	ammonium transporteR
G3580_RS15225	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
G3580_RS15235	COG0494	nUDIX hydrolase
G3580_RS15240	COG2239	Acts as a magnesium transporter
G3580_RS15245	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
G3580_RS15250	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
G3580_RS15255	COG0237	dephospho-CoA kinase activity
G3580_RS15265	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G3580_RS15280	COG3852	Histidine kinase
G3580_RS15290	COG0174	glutamine synthetase
G3580_RS15300	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G3580_RS15310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G3580_RS15315	COG0662	Cupin 2, conserved barrel domain protein
G3580_RS15320	COG1850	ribulose-bisphosphate carboxylase activity
G3580_RS15325	COG3568	Endonuclease Exonuclease Phosphatase
G3580_RS15330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G3580_RS15335	COG1832	CoA-binding protein
G3580_RS15340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3580_RS15355	COG0193	aminoacyl-tRNA hydrolase activity
G3580_RS15360	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G3580_RS15365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G3580_RS15375	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G3580_RS15380	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
G3580_RS15390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G3580_RS15395	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
G3580_RS15400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G3580_RS15405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G3580_RS15410	COG0742	ribosomal rna small subunit methyltransferase
G3580_RS15415	COG0612	Peptidase, M16
G3580_RS15420	COG0612	Peptidase, M16
G3580_RS15430	COG2884	Cell division ATP-binding protein ftsE
G3580_RS15435	COG2177	Part of the ABC transporter FtsEX involved in
G3580_RS15450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G3580_RS15455	COG2176	DNA-directed DNA polymerase activity
G3580_RS15455	COG5002	protein histidine kinase activity
G3580_RS15460	COG0745	RESPONSE REGULATOR receiver
G3580_RS15465	COG5002	protein histidine kinase activity
G3580_RS15475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G3580_RS15520	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G3580_RS15530	COG1982	Orn Lys Arg decarboxylase major
G3580_RS15535	COG0717	Belongs to the dCTP deaminase family
G3580_RS15540	COG0489	protein tyrosine kinase activity
G3580_RS15550	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G3580_RS15550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G3580_RS15560	COG1254	Belongs to the acylphosphatase family
G3580_RS15565	COG0659	secondary active sulfate transmembrane transporter activity
G3580_RS15580	COG3920	Histidine kinase
G3580_RS15590	COG0679	Auxin Efflux Carrier
G3580_RS15595	COG0705	Rhomboid family
G3580_RS15605	COG0583	DNA-binding transcription factor activity
G3580_RS15610	COG3706	GGDEF domain
G3580_RS15650	COG0280	phosphate acetyltransferase
G3580_RS15650	COG0281	malic enzyme
G3580_RS15655	COG1192	Involved in chromosome partitioning
G3580_RS15665	COG3909	cytochrome
G3580_RS15675	COG0210	DNA helicase
G3580_RS15685	COG0495	leucyl-tRNA aminoacylation
G3580_RS15695	COG1466	dna polymerase III delta subunit
G3580_RS15700	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G3580_RS15715	COG4974	Belongs to the 'phage' integrase family
G3580_RS15720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G3580_RS15735	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G3580_RS15740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G3580_RS15745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G3580_RS15770	COG3300	MHYT domain
G3580_RS15770	COG5001	Diguanylate cyclase
G3580_RS15795	COG1058	Belongs to the CinA family
G3580_RS15795	COG1546	Belongs to the CinA family
G3580_RS15805	COG1643	Atp-dependent helicase
G3580_RS15810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G3580_RS15830	COG0784	Response regulator, receiver
G3580_RS15830	COG2205	protein histidine kinase activity
G3580_RS15830	COG5002	protein histidine kinase activity
G3580_RS15840	COG4206	TonB-dependent receptor
G3580_RS15845	COG4771	TonB-dependent receptor
G3580_RS15850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3580_RS15860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3580_RS15865	COG1136	(ABC) transporter
G3580_RS15865	COG0577	efflux transmembrane transporter activity
G3580_RS15870	COG1136	(ABC) transporter
G3580_RS15870	COG0577	efflux transmembrane transporter activity
G3580_RS15875	COG0577	efflux transmembrane transporter activity
G3580_RS15875	COG1136	(ABC) transporter
G3580_RS15880	COG1187	pseudouridine synthase activity
G3580_RS15885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G3580_RS15885	COG2111	Na H antiporter
G3580_RS15895	COG1007	ATP synthesis coupled electron transport
G3580_RS15900	COG0651	ATP synthesis coupled electron transport
G3580_RS15905	COG1006	Multisubunit Na H antiporter MnhC subunit
G3580_RS15930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G3580_RS15935	COG1414	Transcriptional regulator
G3580_RS15950	COG0280	phosphate acetyltransferase
G3580_RS15950	COG0281	malic enzyme
G3580_RS15955	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
G3580_RS15965	COG0741	lytic transglycosylase activity
G3580_RS15970	COG1652	LysM domain
G3580_RS15995	COG0436	Aminotransferase
G3580_RS16000	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
G3580_RS16005	COG0235	Class ii aldolase
G3580_RS16025	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
G3580_RS16030	COG2084	Dehydrogenase
G3580_RS16035	COG2084	Dehydrogenase
G3580_RS16040	COG2198	Histidine kinase
G3580_RS16040	COG2205	protein histidine kinase activity
G3580_RS16040	COG0784	Response regulator, receiver
G3580_RS16045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G3580_RS16050	COG0243	molybdopterin cofactor binding
G3580_RS16075	COG0348	domain, Protein
G3580_RS16085	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G3580_RS16090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G3580_RS16095	COG2146	nitrite reductase [NAD(P)H] activity
G3580_RS16100	COG2223	nitrite transmembrane transporter activity
G3580_RS16105	COG2815	serine threonine protein kinase
G3580_RS16105	COG0515	serine threonine protein kinase
G3580_RS16110	COG3707	response regulator
G3580_RS16130	COG1116	anion transmembrane transporter activity
G3580_RS16135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3580_RS16140	COG1116	anion transmembrane transporter activity
G3580_RS16140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3580_RS16145	COG0745	RESPONSE REGULATOR receiver
G3580_RS16155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3580_RS16155	COG2205	protein histidine kinase activity
G3580_RS16175	COG0745	RESPONSE REGULATOR receiver
G3580_RS16180	COG5002	protein histidine kinase activity
G3580_RS16190	COG0739	heme binding
G3580_RS16195	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G3580_RS16220	COG3321	synthase
G3580_RS16220	COG0604	alcohol dehydrogenase
G3580_RS16220	COG1028	Short-chain dehydrogenase reductase Sdr
G3580_RS16225	COG0629	single-stranded DNA binding
G3580_RS16230	COG2814	Major facilitator Superfamily
G3580_RS16250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G3580_RS16255	COG2847	Copper chaperone PCu(A)C
G3580_RS16265	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
G3580_RS16270	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G3580_RS16275	COG0203	ribosomal protein L17
G3580_RS16280	COG0202	RNA polymerase activity
G3580_RS16285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G3580_RS16290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G3580_RS16295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G3580_RS16300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G3580_RS16305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G3580_RS16310	COG0201	protein transport
G3580_RS16315	COG0200	Binds to the 23S rRNA
G3580_RS16320	COG1841	ribosomal large subunit assembly
G3580_RS16325	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G3580_RS16330	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G3580_RS16335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G3580_RS16340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G3580_RS16345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G3580_RS16350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G3580_RS16355	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G3580_RS16365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G3580_RS16370	COG0255	Belongs to the universal ribosomal protein uL29 family
G3580_RS16375	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G3580_RS16380	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G3580_RS16385	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G3580_RS16390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G3580_RS16395	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G3580_RS16400	COG0089	rRNA binding
G3580_RS16405	COG0088	Forms part of the polypeptide exit tunnel
G3580_RS16410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G3580_RS16415	COG0051	transcription antitermination factor activity, RNA binding
G3580_RS16420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G3580_RS16425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G3580_RS16430	COG0049	tRNA binding
G3580_RS16435	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G3580_RS16440	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G3580_RS16445	COG0085	RNA polymerase activity
G3580_RS16450	COG0222	ribosome binding
G3580_RS16455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G3580_RS16460	COG0081	regulation of translation
G3580_RS16465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G3580_RS16475	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G3580_RS16485	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G3580_RS16525	COG4206	TonB-dependent receptor
G3580_RS16535	COG2205	protein histidine kinase activity
G3580_RS16535	COG2198	Histidine kinase
G3580_RS16535	COG0784	Response regulator, receiver
G3580_RS16565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3580_RS16590	COG0559	Belongs to the binding-protein-dependent transport system permease family
G3580_RS16600	COG1022	Amp-dependent synthetase and ligase
G3580_RS16675	COG2010	Cytochrome c
G3580_RS16690	COG1648	precorrin-2 dehydrogenase activity
G3580_RS16690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G3580_RS16715	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
G3580_RS16740	COG4263	nitrous-oxide reductase activity
G3580_RS16745	COG2010	Cytochrome c
G3580_RS16755	COG0069	glutamate synthase activity
G3580_RS16760	COG0028	Belongs to the TPP enzyme family
G3580_RS16805	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
G3580_RS16890	COG0625	glutathione transferase activity
G3580_RS16900	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
G3580_RS16945	COG1703	isobutyryl-CoA mutase activity
G3580_RS16945	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G3580_RS16945	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G3580_RS16975	COG0583	DNA-binding transcription factor activity
G3580_RS16980	COG2814	Major facilitator Superfamily
G3580_RS16990	COG1509	lysine 2,3-aminomutase activity
G3580_RS16995	COG4770	biotin carboxylase activity
G3580_RS17000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G3580_RS17005	COG1703	isobutyryl-CoA mutase activity
G3580_RS17010	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G3580_RS17010	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G3580_RS17015	COG1802	Transcriptional regulator
G3580_RS17020	COG1024	Enoyl-CoA hydratase
G3580_RS17025	COG0668	transmembrane transport
G3580_RS17045	COG0730	response to heat
G3580_RS17065	COG0577	efflux transmembrane transporter activity
G3580_RS17065	COG1136	(ABC) transporter
G3580_RS17070	COG1136	(ABC) transporter
G3580_RS17070	COG0577	efflux transmembrane transporter activity
G3580_RS17095	COG1492	cobalamin metabolic process
G3580_RS17100	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
G3580_RS17110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G3580_RS17120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3580_RS17125	COG3171	Protein conserved in bacteria
G3580_RS17130	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
G3580_RS17140	COG4681	YaeQ
G3580_RS17145	COG0513	Belongs to the DEAD box helicase family
G3580_RS17150	COG2030	dehydratase
G3580_RS17180	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G3580_RS17195	COG0583	DNA-binding transcription factor activity
G3580_RS17235	COG3795	YCII-related domain
G3580_RS17240	COG4941	Belongs to the sigma-70 factor family
G3580_RS17260	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
G3580_RS17310	COG4191	Histidine kinase
G3580_RS17310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3580_RS17340	COG2205	protein histidine kinase activity
G3580_RS17340	COG2202	Pas domain
G3580_RS17350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3580_RS17355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G3580_RS17375	COG3851	Histidine kinase
G3580_RS17400	COG3501	Rhs element vgr protein
G3580_RS17420	COG2197	response regulator
G3580_RS17425	COG3850	Histidine kinase
G3580_RS17430	COG2181	nitrate reductase activity
G3580_RS17435	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
G3580_RS17440	COG1140	nitrate reductase beta subunit
G3580_RS17445	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
G3580_RS17450	COG2223	nitrite transmembrane transporter activity
G3580_RS17470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G3580_RS17475	COG0798	PFAM Bile acid sodium symporter
G3580_RS17485	COG3284	Transcriptional regulator
G3580_RS17490	COG1012	belongs to the aldehyde dehydrogenase family
G3580_RS17515	COG0745	RESPONSE REGULATOR receiver
G3580_RS17520	COG0642	Histidine kinase
G3580_RS17525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G3580_RS17560	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G3580_RS17585	COG0488	(ABC) transporter
G3580_RS17610	COG0488	(ABC) transporter
G3580_RS17625	COG4176	ABC-type proline glycine betaine transport system permease component
G3580_RS17630	COG2113	Glycine betaine
G3580_RS17655	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G3580_RS17665	COG0583	DNA-binding transcription factor activity
G3580_RS17675	COG0596	Alpha beta hydrolase
G3580_RS17685	COG1301	dicarboxylic acid transport
G3580_RS17690	COG0463	Glycosyl transferase, family 2
G3580_RS17690	COG0457	Tetratricopeptide repeat
G3580_RS17700	COG1652	LysM domain
G3580_RS17720	COG0222	ribosome binding
G3580_RS17770	COG2831	hemolysin activation secretion protein
G3580_RS17775	COG1253	flavin adenine dinucleotide binding
G3580_RS17800	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G3580_RS17815	COG1053	succinate dehydrogenase
G3580_RS17820	COG2188	Transcriptional regulator
G3580_RS17845	COG0477	Major facilitator Superfamily
G3580_RS17855	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G3580_RS17860	COG3153	acetyltransferase
G3580_RS17860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G3580_RS17865	COG3153	acetyltransferase
G3580_RS17865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G3580_RS17870	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
G3580_RS17875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G3580_RS17900	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G3580_RS17925	COG0697	spore germination
G3580_RS17950	COG0433	COG0433 Predicted ATPase
G3580_RS17960	COG0217	transcriptional regulatory protein
G3580_RS18030	COG3193	protein, possibly involved in utilization of glycolate and propanediol
G3580_RS18050	COG0633	Ferredoxin
G3580_RS18050	COG0543	2 iron, 2 sulfur cluster binding
G3580_RS18090	COG2814	Major facilitator Superfamily
G3580_RS18095	COG0606	chelatase, subunit chli
G3580_RS18180	COG1403	HNH endonuclease
G3580_RS18245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G3580_RS18255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G3580_RS18300	COG1450	Type ii and iii secretion system protein
G3580_RS18320	COG2963	transposase activity
G3580_RS18350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G3580_RS18365	COG0347	Belongs to the P(II) protein family
G3580_RS18370	COG0004	ammonium transporteR
G3580_RS18385	COG0788	formyltetrahydrofolate deformylase activity
G3580_RS18400	COG2813	Specifically methylates the guanine in position
G3580_RS18400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3580_RS18405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3580_RS18410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G3580_RS18415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G3580_RS18420	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
G3580_RS18440	COG0189	ligase activity
G3580_RS18455	COG0642	Histidine kinase
G3580_RS18470	COG0745	RESPONSE REGULATOR receiver
G3580_RS18480	COG3764	Sortase (surface protein transpeptidase)
G3580_RS18485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G3580_RS18490	COG0693	protein deglycase activity
G3580_RS18500	COG2308	Evidence 4 Homologs of previously reported genes of
G3580_RS18515	COG3088	subunit of a heme lyase
G3580_RS18520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G3580_RS18530	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
G3580_RS18550	COG4133	protoheme IX ABC transporter activity
G3580_RS18555	COG3706	GGDEF domain
G3580_RS18570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3580_RS18580	COG3043	anaerobic respiration
G3580_RS18585	COG0348	domain, Protein
G3580_RS18590	COG0437	4 iron, 4 sulfur cluster binding
G3580_RS18595	COG0243	molybdopterin cofactor binding
G3580_RS18605	COG0437	4 iron, 4 sulfur cluster binding
G3580_RS18610	COG0322	excinuclease ABC activity
G3580_RS18620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G3580_RS18625	COG1758	RNA polymerase activity
G3580_RS18630	COG0194	GDP metabolic process
G3580_RS18655	COG0583	DNA-binding transcription factor activity
G3580_RS18665	COG0625	glutathione transferase activity
G3580_RS18680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G3580_RS18715	COG3047	cAMP biosynthetic process
G3580_RS18740	COG2914	Belongs to the UPF0125 (RnfH) family
G3580_RS18755	COG4658	electron transport chain
G3580_RS18765	COG2878	Part of a membrane complex involved in electron transport
G3580_RS18770	COG4657	Part of a membrane complex involved in electron transport
G3580_RS18825	COG3411	Ferredoxin
G3580_RS18875	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G3580_RS18890	COG0583	DNA-binding transcription factor activity
G3580_RS18910	COG2854	intermembrane phospholipid transfer
G3580_RS18935	COG3706	GGDEF domain
G3580_RS18955	COG0426	domain, Protein
G3580_RS18960	COG0633	Ferredoxin
G3580_RS18985	COG3360	Dodecin
G3580_RS19025	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3580_RS19055	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
G3580_RS19075	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G3580_RS19100	COG1584	GPR1 FUN34 yaaH family protein
G3580_RS19115	COG1028	Short-chain dehydrogenase reductase Sdr
G3580_RS19150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G3580_RS19160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G3580_RS19175	COG2814	Major facilitator Superfamily
G3580_RS19180	COG3876	Protein conserved in bacteria
G3580_RS19200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3580_RS19240	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
G3580_RS19265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G3580_RS19330	COG1136	(ABC) transporter
G3580_RS19330	COG0577	efflux transmembrane transporter activity
G3580_RS19340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3580_RS19345	COG0688	phosphatidylethanolamine metabolic process
G3580_RS19360	COG5001	Diguanylate cyclase
G3580_RS19365	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G3580_RS19375	COG0564	pseudouridine synthase activity
G3580_RS19380	COG0745	RESPONSE REGULATOR receiver
G3580_RS19385	COG0432	Pfam Uncharacterised protein family UPF0047
G3580_RS19390	COG1959	2 iron, 2 sulfur cluster binding
G3580_RS19400	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G3580_RS19420	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G3580_RS19435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G3580_RS19440	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G3580_RS19445	COG1984	allophanate hydrolase subunit 2
G3580_RS19450	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G3580_RS19470	COG0484	heat shock protein binding
G3580_RS19520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G3580_RS19535	COG0505	Belongs to the CarA family
G3580_RS19545	COG2081	HI0933 family
G3580_RS19550	COG0668	transmembrane transport
G3580_RS19565	COG1671	Belongs to the UPF0178 family
G3580_RS19570	COG2885	chlorophyll binding
G3580_RS19575	COG0784	Response regulator, receiver
G3580_RS19575	COG4191	Histidine kinase
G3580_RS19590	COG2974	May be involved in recombination
G3580_RS19600	COG1187	pseudouridine synthase activity
G3580_RS19615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G3580_RS19625	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
G3580_RS19630	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G3580_RS19640	COG2814	Major facilitator Superfamily
G3580_RS19655	COG1940	carbohydrate kinase activity
G3580_RS19660	COG2258	MOSC domain
G3580_RS19670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G3580_RS19675	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G3580_RS19680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G3580_RS19690	COG0569	domain protein
G3580_RS19695	COG2204	response regulator
G3580_RS19700	COG5000	phosphorelay sensor kinase activity
G3580_RS19715	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G3580_RS19720	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
G3580_RS19730	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G3580_RS19735	COG0706	membrane insertase activity
G3580_RS19740	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G3580_RS19745	COG0594	ribonuclease P activity
G3580_RS19750	COG0230	Belongs to the bacterial ribosomal protein bL34 family