locus-tag	class	description
D9623_RS00015	COG2835	tetraacyldisaccharide 4'-kinase activity
D9623_RS00020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D9623_RS00025	COG3118	belongs to the thioredoxin family
D9623_RS00040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D9623_RS00065	COG3437	response regulator, receiver
D9623_RS00070	COG2902	Dehydrogenase
D9623_RS00075	COG2264	protein methyltransferase activity
D9623_RS00100	COG0138	bifunctional purine biosynthesis protein purh
D9623_RS00110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D9623_RS00110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D9623_RS00125	COG0501	Belongs to the peptidase M48B family
D9623_RS00130	COG5508	conserved small protein
D9623_RS00145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9623_RS00160	COG2350	Protein conserved in bacteria
D9623_RS00165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D9623_RS00180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D9623_RS00185	COG0181	hydroxymethylbilane synthase activity
D9623_RS00215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9623_RS00245	COG2885	chlorophyll binding
D9623_RS00255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9623_RS00265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_RS00265	COG4191	Histidine kinase
D9623_RS00270	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D9623_RS00290	COG0784	Response regulator, receiver
D9623_RS00290	COG2205	protein histidine kinase activity
D9623_RS00290	COG5002	protein histidine kinase activity
D9623_RS00305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_RS00325	COG0582	viral genome integration into host DNA
D9623_RS00410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D9623_RS00415	COG0443	Heat shock 70 kDa protein
D9623_RS00480	COG0514	ATP-dependent DNA helicase (RecQ)
D9623_RS00525	COG2967	ApaG domain
D9623_RS00530	COG0302	gtp cyclohydrolase
D9623_RS00540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D9623_RS00550	COG0302	gtp cyclohydrolase
D9623_RS00555	COG2205	protein histidine kinase activity
D9623_RS00570	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS00585	COG0285	dihydrofolate synthase activity
D9623_RS00590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D9623_RS00600	COG0133	tryptophan synthase activity
D9623_RS00605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_RS00615	COG2205	protein histidine kinase activity
D9623_RS00620	COG1252	NADH dehydrogenase
D9623_RS00650	COG0802	atpase or kinase
D9623_RS00660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D9623_RS00665	COG2887	Belongs to the helicase family. UvrD subfamily
D9623_RS00675	COG1074	ATP-dependent DNA helicase activity
D9623_RS00685	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D9623_RS00690	COG4133	protoheme IX ABC transporter activity
D9623_RS00695	COG2985	domain, Protein
D9623_RS00740	COG1872	DUF167
D9623_RS00745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D9623_RS00750	COG0598	Magnesium transport protein CorA
D9623_RS00760	COG2154	pterin-4-alpha-carbinolamine dehydratase
D9623_RS00770	COG1573	uracil-dna glycosylase
D9623_RS00775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D9623_RS00780	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D9623_RS00790	COG0583	DNA-binding transcription factor activity
D9623_RS00795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D9623_RS00805	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D9623_RS00810	COG1138	Cytochrome C-type biogenesis protein
D9623_RS00815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9623_RS00820	COG3088	subunit of a heme lyase
D9623_RS00825	COG4235	cytochrome complex assembly
D9623_RS00830	COG0697	spore germination
D9623_RS00835	COG3339	Conserved Protein
D9623_RS00840	COG2897	thiosulfate sulfurtransferase activity
D9623_RS00855	COG0137	argininosuccinate synthase activity
D9623_RS00870	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D9623_RS00880	COG1595	DNA-templated transcription, initiation
D9623_RS00910	COG0004	ammonium transporteR
D9623_RS00915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D9623_RS00920	COG0297	glycogen (starch) synthase activity
D9623_RS00930	COG0481	GTPase activity
D9623_RS00945	COG0583	DNA-binding transcription factor activity
D9623_RS00955	COG3437	response regulator, receiver
D9623_RS00955	COG0784	Response regulator, receiver
D9623_RS00970	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D9623_RS00975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D9623_RS00980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D9623_RS00995	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D9623_RS01020	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D9623_RS01025	COG0583	DNA-binding transcription factor activity
D9623_RS01030	COG0477	Major facilitator Superfamily
D9623_RS01045	COG1253	flavin adenine dinucleotide binding
D9623_RS01050	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D9623_RS01070	COG2205	protein histidine kinase activity
D9623_RS01070	COG2202	Pas domain
D9623_RS01105	COG0803	Belongs to the bacterial solute-binding protein 9 family
D9623_RS01110	COG1121	(ABC) transporter
D9623_RS01115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9623_RS01115	COG1321	iron dependent repressor
D9623_RS01120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9623_RS01125	COG0784	Response regulator, receiver
D9623_RS01125	COG2205	protein histidine kinase activity
D9623_RS01125	COG5002	protein histidine kinase activity
D9623_RS01130	COG1278	Cold shock
D9623_RS01135	COG2204	response regulator
D9623_RS01140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D9623_RS01145	COG0756	dUTP diphosphatase activity
D9623_RS01155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D9623_RS01165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D9623_RS01180	COG0745	RESPONSE REGULATOR receiver
D9623_RS01190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D9623_RS01200	COG0573	inorganic phosphate transmembrane transporter activity
D9623_RS01205	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D9623_RS01210	COG5002	protein histidine kinase activity
D9623_RS01215	COG0280	phosphate acetyltransferase
D9623_RS01215	COG0281	malic enzyme
D9623_RS01220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_RS01230	COG2217	Heavy metal translocating P-type atpase
D9623_RS01280	COG2132	Multicopper oxidase
D9623_RS01295	COG1177	transmembrane transport
D9623_RS01300	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_RS01320	COG3842	ATPase activity
D9623_RS01325	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D9623_RS01330	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D9623_RS01335	COG0268	Binds directly to 16S ribosomal RNA
D9623_RS01340	COG1024	Enoyl-CoA hydratase
D9623_RS01350	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D9623_RS01360	COG0457	Tetratricopeptide repeat
D9623_RS01360	COG0859	PFAM glycosyl transferase family 9
D9623_RS01365	COG2226	methyltransferase
D9623_RS01370	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D9623_RS01380	COG4166	transmembrane transport
D9623_RS01385	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D9623_RS01390	COG0039	L-malate dehydrogenase activity
D9623_RS01420	COG1592	Rubrerythrin
D9623_RS01435	COG0584	glycerophosphoryl diester phosphodiesterase
D9623_RS01440	COG1509	lysine 2,3-aminomutase activity
D9623_RS01450	COG2321	neutral zinc metallopeptidase
D9623_RS01460	COG1185	polyribonucleotide nucleotidyltransferase activity
D9623_RS01470	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D9623_RS01495	COG0779	Required for maturation of 30S ribosomal subunits
D9623_RS01500	COG2329	Antibiotic biosynthesis monooxygenase
D9623_RS01505	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D9623_RS01510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D9623_RS01515	COG1396	sequence-specific DNA binding
D9623_RS01520	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D9623_RS01525	COG1253	flavin adenine dinucleotide binding
D9623_RS01535	COG1702	phosphate starvation-inducible protein PhoH
D9623_RS01540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9623_RS01570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D9623_RS01575	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D9623_RS01585	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D9623_RS01610	COG0730	response to heat
D9623_RS01615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9623_RS01630	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D9623_RS01640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D9623_RS01645	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D9623_RS01655	COG1121	(ABC) transporter
D9623_RS01660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9623_RS01680	COG0247	lactate metabolic process
D9623_RS01685	COG1139	Iron-sulfur cluster binding protein
D9623_RS01690	COG1556	Lactate utilization protein
D9623_RS01705	COG2205	protein histidine kinase activity
D9623_RS01710	COG0488	(ABC) transporter
D9623_RS01715	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D9623_RS01770	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D9623_RS01775	COG4395	Tim44
D9623_RS01785	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D9623_RS01790	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D9623_RS01810	COG1981	membrane
D9623_RS01835	COG0237	dephospho-CoA kinase activity
D9623_RS01840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9623_RS01850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D9623_RS01855	COG1331	Highly conserved protein containing a thioredoxin domain
D9623_RS01865	COG3411	Ferredoxin
D9623_RS01875	COG0445	tRNA wobble uridine modification
D9623_RS01880	COG0357	Ribosomal RNA small subunit methyltransferase G
D9623_RS01955	COG0745	RESPONSE REGULATOR receiver
D9623_RS01975	COG1234	tRNA 3'-trailer cleavage
D9623_RS01985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9623_RS01990	COG0601	transmembrane transport
D9623_RS01995	COG0747	negative chemotaxis
D9623_RS02025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_RS02025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9623_RS02030	COG1132	(ABC) transporter
D9623_RS02045	COG3706	GGDEF domain
D9623_RS02050	COG0438	transferase activity, transferring glycosyl groups
D9623_RS02075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D9623_RS02080	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D9623_RS02085	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D9623_RS02100	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS02105	COG1309	transcriptional regulator
D9623_RS02110	COG0110	maltose O-acetyltransferase activity
D9623_RS02125	COG3012	SEC-C Motif Domain Protein
D9623_RS02135	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D9623_RS02140	COG0180	Tryptophanyl-tRNA synthetase
D9623_RS02150	COG0784	Response regulator, receiver
D9623_RS02150	COG2205	protein histidine kinase activity
D9623_RS02190	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D9623_RS02200	COG1366	Belongs to the anti-sigma-factor antagonist family
D9623_RS02220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D9623_RS02225	COG0792	nuclease activity
D9623_RS02255	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D9623_RS02260	COG0840	transmembrane signaling receptor activity
D9623_RS02265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D9623_RS02270	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D9623_RS02275	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D9623_RS02280	COG1420	regulation of RNA biosynthetic process
D9623_RS02315	COG0443	Heat shock 70 kDa protein
D9623_RS02325	COG3706	GGDEF domain
D9623_RS02335	COG4181	ATPase activity
D9623_RS02350	COG0667	Aldo Keto reductase
D9623_RS02355	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D9623_RS02360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D9623_RS02365	COG0347	Belongs to the P(II) protein family
D9623_RS02370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D9623_RS02445	COG2264	protein methyltransferase activity
D9623_RS02480	COG3485	protocatechuate 3,4-dioxygenase
D9623_RS02490	COG0464	growth
D9623_RS02520	COG3436	PFAM IS66 Orf2 family protein
D9623_RS02525	COG4372	Transposase
D9623_RS02600	COG0747	negative chemotaxis
D9623_RS02610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9623_RS02615	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D9623_RS02635	COG3685	Protein conserved in bacteria
D9623_RS02655	COG1013	pyruvate-flavodoxin oxidoreductase activity
D9623_RS02660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D9623_RS02660	COG0674	pyruvate-flavodoxin oxidoreductase activity
D9623_RS02665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D9623_RS02670	COG2205	protein histidine kinase activity
D9623_RS02670	COG2202	Pas domain
D9623_RS02675	COG0693	protein deglycase activity
D9623_RS02680	COG2224	Isocitrate lyase
D9623_RS02685	COG1396	sequence-specific DNA binding
D9623_RS02685	COG3800	Transcriptional regulator
D9623_RS02700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D9623_RS02705	COG0784	Response regulator, receiver
D9623_RS02705	COG3437	response regulator, receiver
D9623_RS02710	COG0668	transmembrane transport
D9623_RS02740	COG1612	heme a metabolic process
D9623_RS02745	COG0543	2 iron, 2 sulfur cluster binding
D9623_RS02745	COG0493	'glutamate synthase
D9623_RS02750	COG3772	lysozyme
D9623_RS02755	COG5425	PFAM Usg family protein
D9623_RS02760	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D9623_RS02765	COG0459	protein refolding
D9623_RS02770	COG0753	catalase activity
D9623_RS02775	COG1858	cytochrome C peroxidase
D9623_RS02780	COG3005	denitrification pathway
D9623_RS02795	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D9623_RS02805	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D9623_RS02810	COG1842	Phage shock protein A
D9623_RS02820	COG1983	PspC domain protein
D9623_RS02835	COG3437	response regulator, receiver
D9623_RS02835	COG0784	Response regulator, receiver
D9623_RS02845	COG0671	phosphoesterase, PA-phosphatase related
D9623_RS02885	COG0747	negative chemotaxis
D9623_RS02895	COG0601	transmembrane transport
D9623_RS02900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9623_RS02905	COG0444	Belongs to the ABC transporter superfamily
D9623_RS02945	COG1278	Cold shock
D9623_RS02950	COG0033	Phosphoglucomutase
D9623_RS02955	COG0412	Dienelactone hydrolase
D9623_RS02965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9623_RS02995	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_RS03000	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D9623_RS03030	COG0514	ATP-dependent DNA helicase (RecQ)
D9623_RS03035	COG0494	nUDIX hydrolase
D9623_RS03045	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D9623_RS03050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9623_RS03055	COG0653	protein targeting
D9623_RS03060	COG1970	mechanosensitive ion channel activity
D9623_RS03065	COG0513	Belongs to the DEAD box helicase family
D9623_RS03070	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D9623_RS03090	COG4106	trans-aconitate 2-methyltransferase activity
D9623_RS03095	COG1987	bacterial-type flagellum assembly
D9623_RS03100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D9623_RS03105	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D9623_RS03110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9623_RS03115	COG1971	Probably functions as a manganese efflux pump
D9623_RS03130	COG3162	membrane
D9623_RS03155	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D9623_RS03180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D9623_RS03210	COG0071	Belongs to the small heat shock protein (HSP20) family
D9623_RS03220	COG0463	Glycosyl transferase, family 2
D9623_RS03230	COG5002	protein histidine kinase activity
D9623_RS03230	COG2205	protein histidine kinase activity
D9623_RS03230	COG0784	Response regulator, receiver
D9623_RS03250	COG1741	Belongs to the pirin family
D9623_RS03270	COG0405	Gamma-glutamyltransferase
D9623_RS03285	COG0539	negative regulation of cytoplasmic translation
D9623_RS03295	COG0776	regulation of translation
D9623_RS03305	COG2423	ornithine cyclodeaminase activity
D9623_RS03325	COG0135	phosphoribosylanthranilate isomerase activity
D9623_RS03335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D9623_RS03340	COG1178	ABC-type Fe3 transport system permease component
D9623_RS03345	COG1741	Belongs to the pirin family
D9623_RS03350	COG1840	ABC-type Fe3 transport system, periplasmic component
D9623_RS03380	COG0271	Belongs to the BolA IbaG family
D9623_RS03395	COG0517	IMP dehydrogenase activity
D9623_RS03400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D9623_RS03420	COG4974	Belongs to the 'phage' integrase family
D9623_RS03435	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D9623_RS03445	COG0825	malonyl-CoA metabolic process
D9623_RS03460	COG0598	Magnesium transport protein CorA
D9623_RS03470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D9623_RS03485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D9623_RS03490	COG0706	membrane insertase activity
D9623_RS03495	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D9623_RS03505	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D9623_RS03515	COG1215	transferase activity, transferring glycosyl groups
D9623_RS03545	COG0438	transferase activity, transferring glycosyl groups
D9623_RS03560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9623_RS03570	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D9623_RS03580	COG0489	protein tyrosine kinase activity
D9623_RS03580	COG3206	protein involved in exopolysaccharide biosynthesis
D9623_RS03595	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D9623_RS03605	COG1131	(ABC) transporter
D9623_RS03615	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9623_RS03630	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D9623_RS03645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_RS03685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D9623_RS03690	COG0228	four-way junction DNA binding
D9623_RS03695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D9623_RS03705	COG0335	large ribosomal subunit rRNA binding
D9623_RS03720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D9623_RS03725	COG2378	regulation of single-species biofilm formation
D9623_RS03745	COG0101	tRNA pseudouridine synthase activity
D9623_RS03750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D9623_RS03755	COG0242	peptide deformylase activity
D9623_RS03765	COG1278	Cold shock
D9623_RS03770	COG1322	Protein conserved in bacteria
D9623_RS03785	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS03800	COG0156	8-amino-7-oxononanoate synthase activity
D9623_RS03810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D9623_RS03815	COG0625	glutathione transferase activity
D9623_RS03820	COG5001	Diguanylate cyclase
D9623_RS03845	COG0583	DNA-binding transcription factor activity
D9623_RS03875	COG0625	glutathione transferase activity
D9623_RS03880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D9623_RS03915	COG0587	DNA-directed DNA polymerase activity
D9623_RS03935	COG2358	TRAP transporter, solute receptor (TAXI family
D9623_RS03945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D9623_RS03950	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9623_RS03985	COG4172	Belongs to the ABC transporter superfamily
D9623_RS03990	COG4239	(ABC) transporter, permease
D9623_RS03995	COG4174	ABC transporter (Permease)
D9623_RS04000	COG4166	transmembrane transport
D9623_RS04010	COG4166	transmembrane transport
D9623_RS04040	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D9623_RS04045	COG3474	cytochrome
D9623_RS04060	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D9623_RS04070	COG0126	phosphoglycerate kinase activity
D9623_RS04075	COG2226	methyltransferase
D9623_RS04095	COG4106	trans-aconitate 2-methyltransferase activity
D9623_RS04100	COG4191	Histidine kinase
D9623_RS04120	COG0596	Alpha beta hydrolase
D9623_RS04130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9623_RS04135	COG4974	Belongs to the 'phage' integrase family
D9623_RS04145	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D9623_RS04165	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D9623_RS04175	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D9623_RS04195	COG1051	belongs to the nudix hydrolase family
D9623_RS04205	COG0793	Belongs to the peptidase S41A family
D9623_RS04215	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D9623_RS04220	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D9623_RS04225	COG0799	negative regulation of ribosome biogenesis
D9623_RS04240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D9623_RS04240	COG2010	Cytochrome c
D9623_RS04260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D9623_RS04270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D9623_RS04280	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D9623_RS04320	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D9623_RS04345	COG0463	Glycosyl transferase, family 2
D9623_RS04355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D9623_RS04370	COG0723	plastoquinol--plastocyanin reductase activity
D9623_RS04415	COG2205	protein histidine kinase activity
D9623_RS04425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9623_RS04435	COG3279	Response regulator of the LytR AlgR family
D9623_RS04450	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D9623_RS04455	COG1902	pentaerythritol trinitrate reductase activity
D9623_RS04465	COG2962	Rard protein
D9623_RS04475	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D9623_RS04485	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D9623_RS04490	COG0047	phosphoribosylformylglycinamidine synthase activity
D9623_RS04495	COG0583	DNA-binding transcription factor activity
D9623_RS04505	COG2258	MOSC domain
D9623_RS04515	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D9623_RS04520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D9623_RS04535	COG0601	transmembrane transport
D9623_RS04540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9623_RS04545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D9623_RS04565	COG0024	Methionine aminopeptidase
D9623_RS04570	COG1489	DNA binding
D9623_RS04575	COG1546	Belongs to the CinA family
D9623_RS04575	COG1058	Belongs to the CinA family
D9623_RS04625	COG0124	histidyl-tRNA synthetase
D9623_RS04630	COG0418	dihydroorotase activity
D9623_RS04640	COG1570	exodeoxyribonuclease VII activity
D9623_RS04655	COG0590	tRNA wobble adenosine to inosine editing
D9623_RS04660	COG3360	Dodecin
D9623_RS04665	COG1187	pseudouridine synthase activity
D9623_RS04670	COG0742	ribosomal rna small subunit methyltransferase
D9623_RS04685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D9623_RS04725	COG1518	maintenance of DNA repeat elements
D9623_RS04735	COG1309	transcriptional regulator
D9623_RS04765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9623_RS04770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9623_RS04780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D9623_RS04815	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS04820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9623_RS04845	COG0667	Aldo Keto reductase
D9623_RS04850	COG2188	Transcriptional regulator
D9623_RS04855	COG0179	Fumarylacetoacetate (FAA) hydrolase
D9623_RS04880	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D9623_RS04885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9623_RS04910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9623_RS04925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9623_RS04945	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D9623_RS04965	COG0166	Belongs to the GPI family
D9623_RS04975	COG0612	Peptidase, M16
D9623_RS04980	COG0612	Peptidase, M16
D9623_RS04990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D9623_RS04995	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D9623_RS05000	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D9623_RS05005	COG0196	riboflavin kinase activity
D9623_RS05010	COG2030	dehydratase
D9623_RS05020	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D9623_RS05050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9623_RS05055	COG2703	oxygen carrier activity
D9623_RS05070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9623_RS05100	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
D9623_RS05105	COG2089	acid synthase
D9623_RS05130	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS05160	COG1294	oxidase, subunit
D9623_RS05165	COG1271	oxidase subunit
D9623_RS05170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D9623_RS05190	COG1127	ABC transporter
D9623_RS05195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D9623_RS05200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9623_RS05215	COG2703	oxygen carrier activity
D9623_RS05255	COG0583	DNA-binding transcription factor activity
D9623_RS05260	COG0667	Aldo Keto reductase
D9623_RS05280	COG0583	DNA-binding transcription factor activity
D9623_RS05325	COG0511	ligase activity, forming carbon-carbon bonds
D9623_RS05330	COG0439	Biotin carboxylase
D9623_RS05335	COG3719	Belongs to the RNase T2 family
D9623_RS05360	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D9623_RS05385	COG1686	Belongs to the peptidase S11 family
D9623_RS05400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D9623_RS05405	COG0746	molybdenum cofactor guanylyltransferase activity
D9623_RS05430	COG3383	formate dehydrogenase (NAD+) activity
D9623_RS05430	COG0243	molybdopterin cofactor binding
D9623_RS05435	COG0437	4 iron, 4 sulfur cluster binding
D9623_RS05460	COG0235	Class ii aldolase
D9623_RS05470	COG3384	dioxygenase
D9623_RS05480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9623_RS05485	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D9623_RS05490	COG0356	it plays a direct role in the translocation of protons across the membrane
D9623_RS05500	COG1999	signal sequence binding
D9623_RS05515	COG1702	phosphate starvation-inducible protein PhoH
D9623_RS05520	COG0850	regulation of cytokinetic process
D9623_RS05525	COG2894	cell division
D9623_RS05530	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D9623_RS05555	COG4948	Mandelate Racemase Muconate Lactonizing
D9623_RS05565	COG1104	cysteine desulfurase activity
D9623_RS05575	COG2154	pterin-4-alpha-carbinolamine dehydratase
D9623_RS05590	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D9623_RS05605	COG0840	transmembrane signaling receptor activity
D9623_RS05615	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D9623_RS05620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D9623_RS05625	COG1278	Cold shock
D9623_RS05660	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D9623_RS05715	COG5420	small protein containing a coiled-coil domain
D9623_RS05730	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D9623_RS05735	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D9623_RS05790	COG0121	glutamine amidotransferase
D9623_RS05805	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D9623_RS05830	COG5554	nitrogen fixation
D9623_RS05845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D9623_RS05870	COG1309	transcriptional regulator
D9623_RS05880	COG1131	(ABC) transporter
D9623_RS05890	COG0842	Transport permease protein
D9623_RS05895	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D9623_RS05905	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D9623_RS05910	COG0277	FAD linked oxidase domain protein
D9623_RS05915	COG0277	FAD linked oxidase domain protein
D9623_RS05920	COG0247	lactate metabolic process
D9623_RS05940	COG1960	acyl-CoA dehydrogenase activity
D9623_RS05955	COG0277	FAD linked oxidase domain protein
D9623_RS05960	COG0009	L-threonylcarbamoyladenylate synthase
D9623_RS05965	COG1192	Involved in chromosome partitioning
D9623_RS05975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D9623_RS05980	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D9623_RS05995	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D9623_RS06000	COG2945	thiolester hydrolase activity
D9623_RS06005	COG1045	serine acetyltransferase
D9623_RS06020	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D9623_RS06025	COG0633	Ferredoxin
D9623_RS06030	COG0482	sulfurtransferase activity
D9623_RS06045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_RS06070	COG4221	oxidoreductase activity
D9623_RS06080	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D9623_RS06095	COG2205	protein histidine kinase activity
D9623_RS06095	COG0784	Response regulator, receiver
D9623_RS06105	COG0745	RESPONSE REGULATOR receiver
D9623_RS06130	COG0432	Pfam Uncharacterised protein family UPF0047
D9623_RS06140	COG2951	lytic endotransglycosylase activity
D9623_RS06160	COG1454	alcohol dehydrogenase
D9623_RS06185	COG0456	acetyltransferase
D9623_RS06200	COG0114	fumarate hydratase activity
D9623_RS06215	COG5001	Diguanylate cyclase
D9623_RS06215	COG5002	protein histidine kinase activity
D9623_RS06220	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D9623_RS06235	COG0205	6-phosphofructokinase activity
D9623_RS06265	COG0288	reversible hydration of carbon dioxide
D9623_RS06280	COG0604	alcohol dehydrogenase
D9623_RS06280	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS06280	COG3321	synthase
D9623_RS06325	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_RS06335	COG0840	transmembrane signaling receptor activity
D9623_RS06355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D9623_RS06360	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D9623_RS06365	COG0343	queuine tRNA-ribosyltransferase activity
D9623_RS06370	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D9623_RS06375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D9623_RS06380	COG0840	transmembrane signaling receptor activity
D9623_RS06450	COG2201	protein-glutamate methylesterase activity
D9623_RS06495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D9623_RS06500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D9623_RS06505	COG0242	peptide deformylase activity
D9623_RS06515	COG3070	regulator of competence-specific genes
D9623_RS06530	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D9623_RS06555	COG4120	Belongs to the binding-protein-dependent transport system permease family
D9623_RS06570	COG0489	protein tyrosine kinase activity
D9623_RS06575	COG0330	HflC and HflK could
D9623_RS06580	COG0330	HflC and HflK could
D9623_RS06605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D9623_RS06610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9623_RS06615	COG0028	Belongs to the TPP enzyme family
D9623_RS06630	COG0704	Plays a role in the regulation of phosphate uptake
D9623_RS06635	COG2862	Uncharacterized protein family, UPF0114
D9623_RS06655	COG0768	penicillin binding
D9623_RS06675	COG1744	ABC transporter substrate-binding protein PnrA-like
D9623_RS06680	COG3845	ABC transporter
D9623_RS06685	COG4603	Belongs to the binding-protein-dependent transport system permease family
D9623_RS06690	COG1079	Belongs to the binding-protein-dependent transport system permease family
D9623_RS06695	COG0295	cytidine deaminase activity
D9623_RS06700	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D9623_RS06705	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D9623_RS06720	COG0697	spore germination
D9623_RS06740	COG0411	ABC transporter
D9623_RS06755	COG0038	chloride channel
D9623_RS06765	COG2326	polyphosphate kinase activity
D9623_RS06770	COG0366	Alpha amylase catalytic
D9623_RS06780	COG2199	diguanylate cyclase activity
D9623_RS06780	COG2203	Gaf domain
D9623_RS06780	COG2200	EAL domain
D9623_RS06790	COG2135	peptidase activity
D9623_RS06800	COG0784	Response regulator, receiver
D9623_RS06805	COG2261	transglycosylase associated protein
D9623_RS06810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D9623_RS06825	COG1733	regulation of RNA biosynthetic process
D9623_RS06835	COG2084	Dehydrogenase
D9623_RS06840	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS06855	COG0546	phosphoglycolate phosphatase activity
D9623_RS06870	COG0521	Mo-molybdopterin cofactor biosynthetic process
D9623_RS06880	COG2832	Protein of unknown function (DUF454)
D9623_RS06885	COG1238	metal cluster binding
D9623_RS06890	COG3852	Histidine kinase
D9623_RS06895	COG0469	pyruvate kinase activity
D9623_RS06900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D9623_RS06915	COG0203	ribosomal protein L17
D9623_RS06920	COG1238	metal cluster binding
D9623_RS06935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D9623_RS06945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D9623_RS06950	COG0564	pseudouridine synthase activity
D9623_RS06955	COG1802	Transcriptional regulator
D9623_RS06960	COG3135	benzoate transporter
D9623_RS06965	COG0546	phosphoglycolate phosphatase activity
D9623_RS06990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D9623_RS06995	COG3845	ABC transporter
D9623_RS07000	COG4603	Belongs to the binding-protein-dependent transport system permease family
D9623_RS07005	COG1079	Belongs to the binding-protein-dependent transport system permease family
D9623_RS07040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D9623_RS07045	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D9623_RS07060	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS07065	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D9623_RS07070	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D9623_RS07080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D9623_RS07085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D9623_RS07090	COG0351	phosphomethylpyrimidine kinase
D9623_RS07095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9623_RS07135	COG2030	dehydratase
D9623_RS07135	COG1012	belongs to the aldehyde dehydrogenase family
D9623_RS07140	COG0443	Heat shock 70 kDa protein
D9623_RS07165	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D9623_RS07165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D9623_RS07215	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9623_RS07220	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9623_RS07230	COG0649	NAD binding
D9623_RS07235	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D9623_RS07245	COG1034	ATP synthesis coupled electron transport
D9623_RS07250	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D9623_RS07255	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9623_RS07265	COG0713	ATP synthesis coupled electron transport
D9623_RS07280	COG1007	ATP synthesis coupled electron transport
D9623_RS07300	COG0346	lactoylglutathione lyase activity
D9623_RS07310	COG0519	Catalyzes the synthesis of GMP from XMP
D9623_RS07325	COG0442	prolyl-tRNA aminoacylation
D9623_RS07360	COG0052	Belongs to the universal ribosomal protein uS2 family
D9623_RS07365	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D9623_RS07370	COG0528	UMP kinase activity
D9623_RS07375	COG0233	cytoplasmic translational termination
D9623_RS07380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D9623_RS07390	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D9623_RS07395	COG0750	zinc metalloprotease
D9623_RS07415	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9623_RS07420	COG3494	Protein of unknown function (DUF1009)
D9623_RS07425	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9623_RS07440	COG0583	DNA-binding transcription factor activity
D9623_RS07455	COG0372	Belongs to the citrate synthase family
D9623_RS07460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D9623_RS07465	COG2333	competence protein COMEC
D9623_RS07465	COG0658	competence protein
D9623_RS07470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D9623_RS07475	COG0303	'Molybdopterin
D9623_RS07480	COG0315	cyclic pyranopterin monophosphate synthase activity
D9623_RS07525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D9623_RS07535	COG0149	triose-phosphate isomerase activity
D9623_RS07565	COG0535	radical SAM domain protein
D9623_RS07570	COG0535	radical SAM domain protein
D9623_RS07575	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
D9623_RS07580	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D9623_RS07590	COG0148	phosphopyruvate hydratase activity
D9623_RS07600	COG0037	tRNA processing
D9623_RS07635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_RS07655	COG0596	Alpha beta hydrolase
D9623_RS07660	COG0728	peptidoglycan biosynthetic process
D9623_RS07670	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9623_RS07685	COG0436	Aminotransferase
D9623_RS07705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_RS07710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9623_RS07725	COG0745	RESPONSE REGULATOR receiver
D9623_RS07735	COG0745	RESPONSE REGULATOR receiver
D9623_RS07740	COG0840	transmembrane signaling receptor activity
D9623_RS07770	COG2205	protein histidine kinase activity
D9623_RS07775	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D9623_RS07805	COG1024	Enoyl-CoA hydratase
D9623_RS07815	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D9623_RS07820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D9623_RS07825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D9623_RS07830	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D9623_RS07835	COG2885	chlorophyll binding
D9623_RS07835	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D9623_RS07840	COG3243	poly(R)-hydroxyalkanoic acid synthase
D9623_RS07865	COG0436	Aminotransferase
D9623_RS07875	COG1494	fructose-1,6-bisphosphatase
D9623_RS07885	COG0371	Dehydrogenase
D9623_RS07890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D9623_RS07890	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D9623_RS07970	COG0656	L-ascorbic acid biosynthetic process
D9623_RS07995	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D9623_RS08000	COG0517	IMP dehydrogenase activity
D9623_RS08015	COG2814	Major facilitator Superfamily
D9623_RS08030	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D9623_RS08045	COG2084	Dehydrogenase
D9623_RS08050	COG3622	Belongs to the hyi family
D9623_RS08055	COG3960	tartronate-semialdehyde synthase activity
D9623_RS08060	COG0352	thiamine-phosphate diphosphorylase activity
D9623_RS08060	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D9623_RS08065	COG1802	Transcriptional regulator
D9623_RS08070	COG0469	pyruvate kinase activity
D9623_RS08080	COG0574	Belongs to the PEP-utilizing enzyme family
D9623_RS08080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D9623_RS08110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_RS08120	COG0693	protein deglycase activity
D9623_RS08125	COG2197	response regulator
D9623_RS08130	COG2197	response regulator
D9623_RS08145	COG0829	nickel cation binding
D9623_RS08150	COG0831	urea catabolic process
D9623_RS08155	COG0832	Belongs to the urease beta subunit family
D9623_RS08160	COG0804	urea catabolic process
D9623_RS08165	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D9623_RS08170	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D9623_RS08175	COG0830	nickel cation binding
D9623_RS08180	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D9623_RS08185	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
D9623_RS08195	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D9623_RS08210	COG0640	Transcriptional regulator
D9623_RS08240	COG1396	sequence-specific DNA binding
D9623_RS08265	COG1846	Transcriptional regulator
D9623_RS08275	COG0704	Plays a role in the regulation of phosphate uptake
D9623_RS08295	COG0463	Glycosyl transferase, family 2
D9623_RS08315	COG1940	carbohydrate kinase activity
D9623_RS08365	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D9623_RS08365	COG2885	chlorophyll binding
D9623_RS08370	COG2197	response regulator
D9623_RS08375	COG0784	Response regulator, receiver
D9623_RS08375	COG2198	Histidine kinase
D9623_RS08375	COG2205	protein histidine kinase activity
D9623_RS08390	COG0564	pseudouridine synthase activity
D9623_RS08395	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS08400	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D9623_RS08415	COG0024	Methionine aminopeptidase
D9623_RS08430	COG1127	ABC transporter
D9623_RS08435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D9623_RS08440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D9623_RS08445	COG0305	Participates in initiation and elongation during chromosome replication
D9623_RS08450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D9623_RS08455	COG0359	binds to the 23S rRNA
D9623_RS08465	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D9623_RS08470	COG0360	Binds together with S18 to 16S ribosomal RNA
D9623_RS08475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D9623_RS08490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9623_RS08495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D9623_RS08505	COG0741	lytic transglycosylase activity
D9623_RS08510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9623_RS08515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D9623_RS08520	COG2813	Specifically methylates the guanine in position
D9623_RS08530	COG1881	PFAM PEBP family protein
D9623_RS08535	COG0113	porphobilinogen synthase activity
D9623_RS08540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D9623_RS08545	COG1597	lipid kinase activity
D9623_RS08550	COG1024	Enoyl-CoA hydratase
D9623_RS08555	COG1846	Transcriptional regulator
D9623_RS08575	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_RS08590	COG0686	Belongs to the AlaDH PNT family
D9623_RS08600	COG0737	Belongs to the 5'-nucleotidase family
D9623_RS08605	COG0512	Glutamine amidotransferase of anthranilate synthase
D9623_RS08610	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D9623_RS08615	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D9623_RS08615	COG3608	succinylglutamate desuccinylase aspartoacylase
D9623_RS08650	COG2358	TRAP transporter, solute receptor (TAXI family
D9623_RS08680	COG0123	including yeast histone deacetylase and acetoin utilization protein
D9623_RS08725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D9623_RS08730	COG0626	cystathionine gamma-synthase activity
D9623_RS08735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_RS08740	COG4597	amino acid ABC transporter
D9623_RS08745	COG0765	amino acid transport
D9623_RS08750	COG1126	abc transporter atp-binding protein
D9623_RS08755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D9623_RS08775	COG2897	thiosulfate sulfurtransferase activity
D9623_RS08790	COG0494	nUDIX hydrolase
D9623_RS08795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9623_RS08820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D9623_RS08830	COG1538	Outer membrane efflux protein
D9623_RS08840	COG0525	valine-tRNA ligase activity
D9623_RS08845	COG0840	transmembrane signaling receptor activity
D9623_RS08860	COG1686	Belongs to the peptidase S11 family
D9623_RS08865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D9623_RS08870	COG0470	DNA polymerase III
D9623_RS08880	COG0084	hydrolase, TatD family'
D9623_RS08885	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D9623_RS08885	COG0321	lipoyl(octanoyl) transferase activity
D9623_RS08900	COG0631	protein serine/threonine phosphatase activity
D9623_RS08910	COG2957	Belongs to the agmatine deiminase family
D9623_RS08915	COG1177	transmembrane transport
D9623_RS08920	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_RS08925	COG3842	ATPase activity
D9623_RS08935	COG0174	glutamine synthetase
D9623_RS08940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_RS08970	COG0861	Integral membrane protein TerC family
D9623_RS08980	COG4957	zinc ion binding
D9623_RS09015	COG1280	lysine exporter protein (LysE YggA)
D9623_RS09025	COG0314	molybdopterin synthase activity
D9623_RS09030	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D9623_RS09040	COG1763	Mo-molybdopterin cofactor biosynthetic process
D9623_RS09045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D9623_RS09055	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS09120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9623_RS09125	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS09130	COG0625	glutathione transferase activity
D9623_RS09200	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D9623_RS09205	COG1692	metallophosphoesterase
D9623_RS09210	COG0217	transcriptional regulatory protein
D9623_RS09225	COG2255	four-way junction helicase activity
D9623_RS09230	COG0824	Thioesterase
D9623_RS09240	COG0848	biopolymer transport protein
D9623_RS09255	COG2885	chlorophyll binding
D9623_RS09265	COG1086	Polysaccharide biosynthesis protein
D9623_RS09275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D9623_RS09280	COG0438	transferase activity, transferring glycosyl groups
D9623_RS09295	COG0367	asparagine synthase
D9623_RS09300	COG0697	spore germination
D9623_RS09310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D9623_RS09320	COG1765	OsmC-like protein
D9623_RS09325	COG0300	oxidoreductase activity
D9623_RS09330	COG2076	Multidrug Resistance protein
D9623_RS09350	COG0784	Response regulator, receiver
D9623_RS09350	COG3437	response regulator, receiver
D9623_RS09365	COG4191	Histidine kinase
D9623_RS09365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_RS09390	COG0484	heat shock protein binding
D9623_RS09395	COG4520	surface antigen
D9623_RS09410	COG0840	transmembrane signaling receptor activity
D9623_RS09415	COG0840	transmembrane signaling receptor activity
D9623_RS09425	COG1234	tRNA 3'-trailer cleavage
D9623_RS09430	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D9623_RS09435	COG0463	Glycosyl transferase, family 2
D9623_RS09445	COG0523	cobalamin synthesis protein
D9623_RS09450	COG0735	belongs to the Fur family
D9623_RS09460	COG0415	Belongs to the DNA photolyase family
D9623_RS09465	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D9623_RS09475	COG1201	RNA secondary structure unwinding
D9623_RS09495	COG2226	methyltransferase
D9623_RS09510	COG2267	carboxylic ester hydrolase activity
D9623_RS09515	COG1846	Transcriptional regulator
D9623_RS09525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_RS09565	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D9623_RS09570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_RS09575	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_RS09580	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS09585	COG1960	acyl-CoA dehydrogenase activity
D9623_RS09600	COG2833	Protein of unknown function (DUF455)
D9623_RS09605	COG1218	3'(2'),5'-bisphosphate nucleotidase
D9623_RS09620	COG0366	Alpha amylase catalytic
D9623_RS09625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D9623_RS09635	COG0745	RESPONSE REGULATOR receiver
D9623_RS09640	COG1640	4-alpha-glucanotransferase
D9623_RS09665	COG5002	protein histidine kinase activity
D9623_RS09665	COG2176	DNA-directed DNA polymerase activity
D9623_RS09670	COG1671	Belongs to the UPF0178 family
D9623_RS09675	COG0488	(ABC) transporter
D9623_RS09690	COG2853	Lipoprotein
D9623_RS09710	COG0646	methionine synthase
D9623_RS09710	COG1410	methionine synthase
D9623_RS09725	COG3706	GGDEF domain
D9623_RS09730	COG2070	2-Nitropropane dioxygenase
D9623_RS09735	COG0243	molybdopterin cofactor binding
D9623_RS09750	COG2824	Alkylphosphonate utilization operon protein PhnA
D9623_RS09780	COG2202	Pas domain
D9623_RS09780	COG2205	protein histidine kinase activity
D9623_RS09800	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D9623_RS09805	COG1752	Esterase of the alpha-beta hydrolase superfamily
D9623_RS09820	COG1773	rubredoxin
D9623_RS09830	COG3108	Peptidase M15
D9623_RS09845	COG0546	phosphoglycolate phosphatase activity
D9623_RS09890	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D9623_RS09895	COG2211	Major facilitator Superfamily
D9623_RS09900	COG3546	catalase activity
D9623_RS09920	COG3411	Ferredoxin
D9623_RS09925	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D9623_RS09935	COG1024	Enoyl-CoA hydratase
D9623_RS09945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D9623_RS10005	COG1492	cobalamin metabolic process
D9623_RS10010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D9623_RS10030	COG3424	synthase
D9623_RS10035	COG1755	Isoprenylcysteine carboxyl methyltransferase
D9623_RS10055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_RS10090	COG1217	gtp-binding protein TYPA
D9623_RS10110	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D9623_RS10120	COG2313	pseudouridylate synthase activity
D9623_RS10130	COG1793	dna ligase
D9623_RS10140	COG2153	protein acetylation
D9623_RS10160	COG3685	Protein conserved in bacteria
D9623_RS10180	COG0698	ribose 5-phosphate isomerase
D9623_RS10185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D9623_RS10190	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D9623_RS10195	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9623_RS10195	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9623_RS10205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D9623_RS10205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D9623_RS10210	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D9623_RS10215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D9623_RS10220	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D9623_RS10230	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D9623_RS10250	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D9623_RS10255	COG0416	fatty acid biosynthetic process
D9623_RS10260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9623_RS10285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D9623_RS10285	COG4651	solute:proton antiporter activity
D9623_RS10300	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9623_RS10315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D9623_RS10315	COG1648	precorrin-2 dehydrogenase activity
D9623_RS10320	COG0175	sulfate reduction
D9623_RS10325	COG0175	sulfate reduction
D9623_RS10335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9623_RS10335	COG1116	anion transmembrane transporter activity
D9623_RS10345	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D9623_RS10365	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_RS10370	COG0789	Transcriptional regulator
D9623_RS10385	COG2814	Major facilitator Superfamily
D9623_RS10390	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D9623_RS10460	COG2197	response regulator
D9623_RS10470	COG2197	response regulator
D9623_RS10490	COG1160	GTP binding
D9623_RS10495	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D9623_RS10495	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D9623_RS10540	COG1012	belongs to the aldehyde dehydrogenase family
D9623_RS10560	COG0668	transmembrane transport
D9623_RS10590	COG1830	Aldolase
D9623_RS10595	COG0352	thiamine-phosphate diphosphorylase activity
D9623_RS10600	COG0730	response to heat
D9623_RS10605	COG2067	long-chain fatty acid transport protein
D9623_RS10610	COG0604	alcohol dehydrogenase
D9623_RS10615	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D9623_RS10620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D9623_RS10625	COG0483	inositol monophosphate 1-phosphatase activity
D9623_RS10650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9623_RS10655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9623_RS10655	COG1565	acr, cog1565
D9623_RS10665	COG0312	modulator of DNA gyrase
D9623_RS10670	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D9623_RS10675	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D9623_RS10685	COG5487	UPF0391 membrane protein
D9623_RS10695	COG0741	lytic transglycosylase activity
D9623_RS10725	COG0564	pseudouridine synthase activity
D9623_RS10745	COG3266	domain, Protein
D9623_RS10745	COG0515	serine threonine protein kinase
D9623_RS10750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D9623_RS10755	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D9623_RS10765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D9623_RS10780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D9623_RS10785	COG1295	ribonuclease BN
D9623_RS10790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D9623_RS10800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D9623_RS10810	COG0745	RESPONSE REGULATOR receiver
D9623_RS10820	COG0616	signal peptide processing
D9623_RS10835	COG0784	Response regulator, receiver
D9623_RS10835	COG2198	Histidine kinase
D9623_RS10835	COG5002	protein histidine kinase activity
D9623_RS10845	COG0390	transport system, permease component
D9623_RS10850	COG0577	efflux transmembrane transporter activity
D9623_RS10850	COG1136	(ABC) transporter
D9623_RS10860	COG0628	permease
D9623_RS10865	COG2205	protein histidine kinase activity
D9623_RS10875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9623_RS10885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D9623_RS10890	COG0251	oxidation-reduction process
D9623_RS10900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D9623_RS10900	COG0551	DNA topoisomerase type I activity
D9623_RS10930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D9623_RS10940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9623_RS10955	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D9623_RS10955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D9623_RS10965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D9623_RS10980	COG0505	Belongs to the CarA family
D9623_RS10990	COG1403	HNH endonuclease
D9623_RS11000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D9623_RS11005	COG1393	Belongs to the ArsC family
D9623_RS11010	COG2890	protein-(glutamine-N5) methyltransferase activity
D9623_RS11015	COG0456	acetyltransferase
D9623_RS11015	COG1214	PFAM Peptidase M22, glycoprotease
D9623_RS11055	COG0538	isocitrate dehydrogenase activity
D9623_RS11065	COG3932	Exopolysaccharide synthesis, ExoD
D9623_RS11085	COG0473	3-isopropylmalate dehydrogenase activity
D9623_RS11115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D9623_RS11135	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D9623_RS11150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D9623_RS11170	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9623_RS11175	COG1684	flagellar biosynthetic protein fliR
D9623_RS11180	COG1987	bacterial-type flagellum assembly
D9623_RS11185	COG1677	Flagellar hook-basal body complex protein FliE
D9623_RS11190	COG1558	bacterial-type flagellum-dependent cell motility
D9623_RS11195	COG1815	bacterial-type flagellum-dependent cell motility
D9623_RS11200	COG2257	FlhB HrpN YscU SpaS Family
D9623_RS11215	COG1338	Plays a role in the flagellum-specific transport system
D9623_RS11230	COG1360	Flagellar Motor Protein
D9623_RS11270	COG4786	Flagellar basal body rod
D9623_RS11275	COG4786	Flagellar basal body rod
D9623_RS11285	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D9623_RS11325	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D9623_RS11350	COG0500	methyltransferase
D9623_RS11360	COG1132	(ABC) transporter
D9623_RS11365	COG0254	rRNA binding
D9623_RS11375	COG0071	Belongs to the small heat shock protein (HSP20) family
D9623_RS11395	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D9623_RS11410	COG2186	Transcriptional regulator
D9623_RS11415	COG0563	adenylate kinase activity
D9623_RS11420	COG0201	protein transport
D9623_RS11425	COG0200	Binds to the 23S rRNA
D9623_RS11430	COG1841	ribosomal large subunit assembly
D9623_RS11445	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D9623_RS11450	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D9623_RS11455	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D9623_RS11465	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D9623_RS11475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D9623_RS11480	COG0255	Belongs to the universal ribosomal protein uL29 family
D9623_RS11485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D9623_RS11490	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D9623_RS11495	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D9623_RS11500	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D9623_RS11505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D9623_RS11510	COG0089	rRNA binding
D9623_RS11515	COG0088	Forms part of the polypeptide exit tunnel
D9623_RS11525	COG0051	transcription antitermination factor activity, RNA binding
D9623_RS11530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D9623_RS11610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D9623_RS11620	COG1940	carbohydrate kinase activity
D9623_RS11635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_RS11645	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D9623_RS11650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D9623_RS11655	COG0509	glycine decarboxylation via glycine cleavage system
D9623_RS11660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D9623_RS11675	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D9623_RS11680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9623_RS11690	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_RS11695	COG0678	peroxiredoxin activity
D9623_RS11700	COG4232	protein-disulfide reductase activity
D9623_RS11705	COG1678	Uncharacterized ACR, COG1678
D9623_RS11715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9623_RS11720	COG0612	Peptidase, M16
D9623_RS11730	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D9623_RS11735	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D9623_RS11740	COG3346	SURF1 family
D9623_RS11765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D9623_RS11775	COG0049	tRNA binding
D9623_RS11790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D9623_RS11795	COG0085	RNA polymerase activity
D9623_RS11800	COG0222	ribosome binding
D9623_RS11805	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D9623_RS11810	COG0081	regulation of translation
D9623_RS11815	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D9623_RS11835	COG0411	ABC transporter
D9623_RS11870	COG0673	inositol 2-dehydrogenase activity
D9623_RS11880	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D9623_RS11890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_RS11895	COG1309	transcriptional regulator
D9623_RS11905	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D9623_RS11925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9623_RS11965	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D9623_RS11970	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9623_RS11975	COG1530	ribonuclease E activity
D9623_RS12005	COG0436	Aminotransferase
D9623_RS12015	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D9623_RS12030	COG2264	protein methyltransferase activity
D9623_RS12040	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D9623_RS12055	COG0312	modulator of DNA gyrase
D9623_RS12065	COG1597	lipid kinase activity
D9623_RS12075	COG0438	transferase activity, transferring glycosyl groups
D9623_RS12085	COG1519	Transferase
D9623_RS12090	COG1663	tetraacyldisaccharide 4'-kinase activity
D9623_RS12125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D9623_RS12135	COG0590	tRNA wobble adenosine to inosine editing
D9623_RS12170	COG3108	Peptidase M15
D9623_RS12175	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9623_RS12175	COG3409	Peptidoglycan-binding domain 1 protein
D9623_RS12205	COG2205	protein histidine kinase activity
D9623_RS12215	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D9623_RS12240	COG1073	alpha beta
D9623_RS12245	COG1380	Effector of murein hydrolase LrgA
D9623_RS12250	COG1346	cytolysis
D9623_RS12255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9623_RS12260	COG0751	glycine-tRNA ligase activity
D9623_RS12265	COG0752	glycyl-tRNA synthetase alpha subunit
D9623_RS12285	COG2890	protein-(glutamine-N5) methyltransferase activity
D9623_RS12295	COG0142	geranyltranstransferase activity
D9623_RS12320	COG4191	Histidine kinase
D9623_RS12320	COG0784	Response regulator, receiver
D9623_RS12335	COG2084	Dehydrogenase
D9623_RS12340	COG0277	FAD linked oxidase domain protein
D9623_RS12355	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D9623_RS12360	COG0488	(ABC) transporter
D9623_RS12380	COG2001	Belongs to the MraZ family
D9623_RS12400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D9623_RS12410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D9623_RS12425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D9623_RS12435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D9623_RS12440	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D9623_RS12445	COG1181	Belongs to the D-alanine--D-alanine ligase family
D9623_RS12450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D9623_RS12455	COG0849	cell division
D9623_RS12460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D9623_RS12475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D9623_RS12495	COG0497	DNA recombination
D9623_RS12500	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D9623_RS12515	COG0745	RESPONSE REGULATOR receiver
D9623_RS12520	COG0006	proline dipeptidase activity
D9623_RS12520	COG0006	proline dipeptidase activity
D9623_RS12530	COG2264	protein methyltransferase activity
D9623_RS12545	COG0210	DNA helicase
D9623_RS12550	COG2197	response regulator
D9623_RS12555	COG2197	response regulator
D9623_RS12585	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D9623_RS12595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D9623_RS12605	COG2205	protein histidine kinase activity
D9623_RS12615	COG2202	Pas domain
D9623_RS12615	COG2205	protein histidine kinase activity
D9623_RS12655	COG2988	succinylglutamate desuccinylase activity
D9623_RS12660	COG3180	Ammonia monooxygenase
D9623_RS12670	COG0628	permease
D9623_RS12675	COG0330	HflC and HflK could
D9623_RS12700	COG0745	RESPONSE REGULATOR receiver
D9623_RS12720	COG1116	anion transmembrane transporter activity
D9623_RS12725	COG1643	Atp-dependent helicase
D9623_RS12740	COG2719	SpoVR family
D9623_RS12745	COG2718	Belongs to the UPF0229 family
D9623_RS12750	COG2766	serine protein kinase
D9623_RS12755	COG0745	RESPONSE REGULATOR receiver
D9623_RS12765	COG2205	protein histidine kinase activity
D9623_RS12765	COG0784	Response regulator, receiver
D9623_RS12775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D9623_RS12790	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D9623_RS12830	COG1116	anion transmembrane transporter activity
D9623_RS12880	COG1131	(ABC) transporter
D9623_RS12890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_RS12890	COG2205	protein histidine kinase activity
D9623_RS12905	COG1012	belongs to the aldehyde dehydrogenase family
D9623_RS12925	COG1238	metal cluster binding
D9623_RS12930	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS12935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D9623_RS12945	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9623_RS12970	COG1674	ftsk spoiiie
D9623_RS12995	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D9623_RS13000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D9623_RS13010	COG1522	sequence-specific DNA binding
D9623_RS13015	COG3660	Nucleoside-diphosphate-sugar epimerase
D9623_RS13030	COG0492	ferredoxin-NADP+ reductase activity
D9623_RS13040	COG0783	Belongs to the Dps family
D9623_RS13050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D9623_RS13055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D9623_RS13095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9623_RS13100	COG2304	oxidoreductase activity
D9623_RS13130	COG1136	(ABC) transporter
D9623_RS13160	COG0411	ABC transporter
D9623_RS13180	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS13185	COG0154	amidase activity
D9623_RS13195	COG1024	Enoyl-CoA hydratase
D9623_RS13200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D9623_RS13205	COG0583	DNA-binding transcription factor activity
D9623_RS13220	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D9623_RS13230	COG0714	Associated with various cellular activities
D9623_RS13265	COG3119	arylsulfatase activity
D9623_RS13330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D9623_RS13335	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D9623_RS13340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D9623_RS13350	COG0167	dihydroorotate dehydrogenase activity
D9623_RS13465	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D9623_RS13485	COG1442	glycosyl transferase family 8
D9623_RS13485	COG1216	Glycosyl transferase, family 2
D9623_RS13495	COG4178	(ABC) transporter
D9623_RS13505	COG2723	6-phospho-beta-galactosidase activity
D9623_RS13510	COG2723	6-phospho-beta-galactosidase activity
D9623_RS13530	COG2819	hydrolase of the alpha beta superfamily
D9623_RS13560	COG4770	biotin carboxylase activity
D9623_RS13565	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D9623_RS13570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D9623_RS13575	COG1960	acyl-CoA dehydrogenase activity
D9623_RS13585	COG3621	Patatin-like phospholipase
D9623_RS13615	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D9623_RS13625	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D9623_RS13635	COG3485	protocatechuate 3,4-dioxygenase
D9623_RS13655	COG0531	amino acid
D9623_RS13735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9623_RS13770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D9623_RS13780	COG2084	Dehydrogenase
D9623_RS13795	COG2972	Histidine kinase
D9623_RS13795	COG0840	transmembrane signaling receptor activity
D9623_RS13805	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D9623_RS13820	COG1199	ATP-dependent helicase activity
D9623_RS13820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9623_RS13825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9623_RS13835	COG2076	Multidrug Resistance protein
D9623_RS13840	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D9623_RS13860	COG0039	L-malate dehydrogenase activity
D9623_RS13865	COG0045	succinate-CoA ligase (ADP-forming) activity
D9623_RS13875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D9623_RS13880	COG0045	succinate-CoA ligase (ADP-forming) activity
D9623_RS13895	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9623_RS13900	COG2205	protein histidine kinase activity
D9623_RS13905	COG3706	GGDEF domain
D9623_RS13910	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D9623_RS13925	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D9623_RS13975	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D9623_RS13980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9623_RS13985	COG0552	protein localization to endoplasmic reticulum
D9623_RS13990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D9623_RS14000	COG2917	probably involved in intracellular septation
D9623_RS14015	COG0745	RESPONSE REGULATOR receiver
D9623_RS14020	COG5002	protein histidine kinase activity
D9623_RS14020	COG2176	DNA-directed DNA polymerase activity
D9623_RS14030	COG5002	protein histidine kinase activity
D9623_RS14040	COG0745	RESPONSE REGULATOR receiver
D9623_RS14045	COG0643	Histidine kinase
D9623_RS14045	COG2198	Histidine kinase
D9623_RS14050	COG0835	chemotaxis
D9623_RS14055	COG0840	transmembrane signaling receptor activity
D9623_RS14065	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D9623_RS14075	COG0840	transmembrane signaling receptor activity
D9623_RS14080	COG1366	Belongs to the anti-sigma-factor antagonist family
D9623_RS14115	COG0745	RESPONSE REGULATOR receiver
D9623_RS14125	COG1366	Belongs to the anti-sigma-factor antagonist family
D9623_RS14155	COG0513	Belongs to the DEAD box helicase family
D9623_RS14175	COG0625	glutathione transferase activity
D9623_RS14185	COG0395	ABC-type sugar transport system, permease component
D9623_RS14205	COG0784	Response regulator, receiver
D9623_RS14205	COG2205	protein histidine kinase activity
D9623_RS14215	COG2814	Major facilitator Superfamily
D9623_RS14220	COG1285	pathogenesis
D9623_RS14250	COG2307	Protein conserved in bacteria
D9623_RS14250	COG2308	Evidence 4 Homologs of previously reported genes of
D9623_RS14255	COG2010	Cytochrome c
D9623_RS14275	COG2017	converts alpha-aldose to the beta-anomer
D9623_RS14280	COG0515	serine threonine protein kinase
D9623_RS14280	COG2815	serine threonine protein kinase
D9623_RS14315	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D9623_RS14325	COG0513	Belongs to the DEAD box helicase family
D9623_RS14335	COG0596	Alpha beta hydrolase
D9623_RS14345	COG0187	DNA topoisomerase II activity
D9623_RS14350	COG1607	acyl-coa hydrolase
D9623_RS14355	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D9623_RS14360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D9623_RS14365	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9623_RS14365	COG0022	dehydrogenase e1 component
D9623_RS14370	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9623_RS14375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9623_RS14380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D9623_RS14385	COG2867	negative regulation of translational initiation
D9623_RS14425	COG2204	response regulator
D9623_RS14435	COG0569	domain protein
D9623_RS14450	COG1923	regulation of RNA biosynthetic process
D9623_RS14455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D9623_RS14470	COG0483	inositol monophosphate 1-phosphatase activity
D9623_RS14485	COG3956	TIGRFAM MazG family protein
D9623_RS14490	COG3260	NADH ubiquinone oxidoreductase 20
D9623_RS14495	COG0649	NAD binding
D9623_RS14500	COG0651	ATP synthesis coupled electron transport
D9623_RS14510	COG0650	Formate hydrogenlyase subunit 4
D9623_RS14515	COG0651	ATP synthesis coupled electron transport
D9623_RS14525	COG2183	response to ionizing radiation
D9623_RS14535	COG1280	lysine exporter protein (LysE YggA)
D9623_RS14565	COG0393	Putative heavy-metal-binding
D9623_RS14570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D9623_RS14585	COG4166	transmembrane transport
D9623_RS14590	COG0625	glutathione transferase activity
D9623_RS14595	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D9623_RS14600	COG0366	Alpha amylase catalytic
D9623_RS14620	COG0840	transmembrane signaling receptor activity
D9623_RS14655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_RS14665	COG0583	DNA-binding transcription factor activity
D9623_RS14670	COG4336	lyase activity
D9623_RS14685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_RS14690	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D9623_RS14695	COG1984	allophanate hydrolase subunit 2
D9623_RS14700	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D9623_RS14715	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D9623_RS14725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D9623_RS14730	COG0058	SHG alpha-glucan phosphorylase activity
D9623_RS14785	COG5002	protein histidine kinase activity
D9623_RS14790	COG0745	RESPONSE REGULATOR receiver
D9623_RS14825	COG0719	Fe-S assembly protein
D9623_RS14830	COG0396	ATPase activity
D9623_RS14835	COG0719	Fe-S assembly protein
D9623_RS14840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D9623_RS14845	COG0822	iron-sulfur transferase activity
D9623_RS14855	COG0316	Belongs to the HesB IscA family
D9623_RS14865	COG0308	aminopeptidase N
D9623_RS14885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D9623_RS14920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9623_RS14925	COG0697	spore germination
D9623_RS14935	COG2814	Major facilitator Superfamily
D9623_RS14940	COG0583	DNA-binding transcription factor activity
D9623_RS14955	COG3383	formate dehydrogenase (NAD+) activity
D9623_RS14960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D9623_RS14975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9623_RS14980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9623_RS15000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D9623_RS15010	COG0129	dihydroxy-acid dehydratase activity
D9623_RS15045	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D9623_RS15050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D9623_RS15055	COG0534	Mate efflux family protein
D9623_RS15095	COG0629	single-stranded DNA binding
D9623_RS15100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D9623_RS15120	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D9623_RS15135	COG1562	ergosterol biosynthetic process
D9623_RS15140	COG1562	ergosterol biosynthetic process
D9623_RS15145	COG1233	COG1233 Phytoene dehydrogenase and related
D9623_RS15155	COG3737	Protein of unknown function (DUF498/DUF598)
D9623_RS15165	COG1862	Preprotein translocase
D9623_RS15185	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D9623_RS15195	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D9623_RS15205	COG0805	protein transport
D9623_RS15210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9623_RS15215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9623_RS15220	COG3842	ATPase activity
D9623_RS15225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D9623_RS15230	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D9623_RS15235	COG1994	Peptidase M50
D9623_RS15240	COG1472	Belongs to the glycosyl hydrolase 3 family
D9623_RS15255	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D9623_RS15260	COG0316	Belongs to the HesB IscA family
D9623_RS15265	COG0708	Exodeoxyribonuclease III
D9623_RS15285	COG0066	3-isopropylmalate dehydratase activity
D9623_RS15290	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D9623_RS15295	COG1053	succinate dehydrogenase
D9623_RS15300	COG1335	isochorismatase
D9623_RS15340	COG0683	leucine binding
D9623_RS15345	COG2188	Transcriptional regulator
D9623_RS15350	COG0717	Belongs to the dCTP deaminase family
D9623_RS15365	COG0730	response to heat
D9623_RS15370	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS15390	COG0303	'Molybdopterin
D9623_RS15395	COG0765	amino acid transport
D9623_RS15400	COG0765	amino acid transport
D9623_RS15405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_RS15410	COG1126	abc transporter atp-binding protein
D9623_RS15415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D9623_RS15420	COG1609	Transcriptional regulator
D9623_RS15425	COG3971	2-oxopent-4-enoate hydratase activity
D9623_RS15435	COG3265	gluconokinase activity
D9623_RS15440	COG1609	Transcriptional regulator
D9623_RS15445	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D9623_RS15450	COG1024	Enoyl-CoA hydratase
D9623_RS15460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9623_RS15465	COG1652	LysM domain
D9623_RS15475	COG1174	glycine betaine transport
D9623_RS15480	COG1125	glycine betaine transport
D9623_RS15485	COG1174	glycine betaine transport
D9623_RS15490	COG1732	Glycine betaine
D9623_RS15495	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D9623_RS15505	COG3842	ATPase activity
D9623_RS15520	COG0581	inorganic phosphate transmembrane transporter activity
D9623_RS15555	COG0745	RESPONSE REGULATOR receiver
D9623_RS15560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_RS15560	COG2205	protein histidine kinase activity
D9623_RS15595	COG2814	Major facilitator Superfamily
D9623_RS15615	COG0758	DNA mediated transformation
D9623_RS15620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D9623_RS15635	COG0179	Fumarylacetoacetate (FAA) hydrolase
D9623_RS15645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_RS15650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_RS15655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D9623_RS15660	COG1737	Transcriptional regulator
D9623_RS15660	COG0837	glucose binding
D9623_RS15665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D9623_RS15675	COG0386	Belongs to the glutathione peroxidase family
D9623_RS15690	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D9623_RS15690	COG3264	Mechanosensitive ion channel
D9623_RS15735	COG0657	acetylesterase activity
D9623_RS15745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D9623_RS15750	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D9623_RS15760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_RS15765	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D9623_RS15780	COG0437	4 iron, 4 sulfur cluster binding
D9623_RS15815	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9623_RS15820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9623_RS15825	COG1845	cytochrome c oxidase, subunit III
D9623_RS15870	COG0601	transmembrane transport
D9623_RS15875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9623_RS15880	COG0444	Belongs to the ABC transporter superfamily
D9623_RS15905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D9623_RS15910	COG1902	pentaerythritol trinitrate reductase activity
D9623_RS15910	COG0446	pyridine nucleotide-disulphide oxidoreductase
D9623_RS15925	COG5564	TIM-barrel signal transduction protein
D9623_RS15925	COG2204	response regulator
D9623_RS15930	COG5441	Belongs to the UPF0261 family
D9623_RS15935	COG5564	TIM-barrel signal transduction protein
D9623_RS15960	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D9623_RS15985	COG0557	exoribonuclease II activity
D9623_RS15990	COG0793	Belongs to the peptidase S41A family
D9623_RS15995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D9623_RS16010	COG2202	Pas domain
D9623_RS16010	COG2205	protein histidine kinase activity
D9623_RS16015	COG5001	Diguanylate cyclase
D9623_RS16015	COG5002	protein histidine kinase activity
D9623_RS16015	COG3447	MASE1 domain protein
D9623_RS16035	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D9623_RS16040	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D9623_RS16050	COG0248	Ppx GppA phosphatase
D9623_RS16055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D9623_RS16065	COG3025	triphosphatase activity
D9623_RS16070	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS16080	COG0628	permease
D9623_RS16085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D9623_RS16095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D9623_RS16100	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D9623_RS16115	COG0105	UTP biosynthetic process
D9623_RS16120	COG0488	(ABC) transporter
D9623_RS16125	COG3932	Exopolysaccharide synthesis, ExoD
D9623_RS16130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D9623_RS16135	COG0300	oxidoreductase activity
D9623_RS16140	COG1561	YicC-like family, N-terminal region
D9623_RS16155	COG3328	transposase activity
D9623_RS16165	COG0519	Catalyzes the synthesis of GMP from XMP
D9623_RS16170	COG1247	-acetyltransferase
D9623_RS16195	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D9623_RS16205	COG3813	Protein conserved in bacteria
D9623_RS16225	COG0741	lytic transglycosylase activity
D9623_RS16255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D9623_RS16260	COG2927	DNA polymerase III (CHI subunit)
D9623_RS16265	COG2205	protein histidine kinase activity
D9623_RS16285	COG0556	nucleotide-excision repair
D9623_RS16300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9623_RS16305	COG1846	Transcriptional regulator
D9623_RS16310	COG1278	Cold shock
D9623_RS16320	COG0745	RESPONSE REGULATOR receiver
D9623_RS16335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_RS16365	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_RS16465	COG3547	Transposase (IS116 IS110 IS902 family)
D9623_RS16505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9623_RS16510	COG1414	Transcriptional regulator
D9623_RS16515	COG2376	Dihydroxyacetone kinase
D9623_RS16535	COG1917	Cupin 2, conserved barrel domain protein
D9623_RS16535	COG4977	sequence-specific DNA binding
D9623_RS16545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_RS16560	COG1063	alcohol dehydrogenase
D9623_RS16565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_RS16575	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_RS16580	COG2721	sulfolactate sulfo-lyase activity
D9623_RS16585	COG0246	Mannitol dehydrogenase
D9623_RS16605	COG2358	TRAP transporter, solute receptor (TAXI family
D9623_RS16610	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D9623_RS16615	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D9623_RS16620	COG0583	DNA-binding transcription factor activity
D9623_RS16625	COG2391	methyltransferase activity
D9623_RS16640	COG3842	ATPase activity
D9623_RS16645	COG4149	molybdate abc transporter
D9623_RS16650	COG1840	ABC-type Fe3 transport system, periplasmic component
D9623_RS16665	COG1686	Belongs to the peptidase S11 family
D9623_RS16710	COG1640	4-alpha-glucanotransferase
D9623_RS16725	COG0745	RESPONSE REGULATOR receiver
D9623_RS16740	COG0625	glutathione transferase activity
D9623_RS16745	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS16750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9623_RS16810	COG2099	Precorrin-6x reductase
D9623_RS16840	COG1797	cobyrinic acid a,c-diamide synthase activity
D9623_RS16845	COG0778	Nitroreductase
D9623_RS16850	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS16855	COG1309	transcriptional regulator
D9623_RS16860	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D9623_RS16865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9623_RS16870	COG0737	Belongs to the 5'-nucleotidase family
D9623_RS16895	COG1749	Flagellar hook protein flgE
D9623_RS16920	COG0795	lipopolysaccharide-transporting ATPase activity
D9623_RS16925	COG0840	transmembrane signaling receptor activity
D9623_RS16930	COG1137	ATPase activity
D9623_RS16945	COG1376	ErfK ybiS ycfS ynhG family protein
D9623_RS16965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D9623_RS17000	COG2723	6-phospho-beta-galactosidase activity
D9623_RS17045	COG0154	amidase activity
D9623_RS17055	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9623_RS17065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9623_RS17080	COG0019	diaminopimelate decarboxylase activity
D9623_RS17100	COG0772	Belongs to the SEDS family
D9623_RS17110	COG0745	RESPONSE REGULATOR receiver
D9623_RS17130	COG1253	flavin adenine dinucleotide binding
D9623_RS17135	COG3932	Exopolysaccharide synthesis, ExoD
D9623_RS17140	COG2205	protein histidine kinase activity
D9623_RS17155	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D9623_RS17175	COG1657	PFAM Prenyltransferase squalene oxidase
D9623_RS17200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9623_RS17205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D9623_RS17210	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D9623_RS17215	COG2080	2 iron, 2 sulfur cluster binding
D9623_RS17220	COG0583	DNA-binding transcription factor activity
D9623_RS17235	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D9623_RS17245	COG1960	acyl-CoA dehydrogenase activity
D9623_RS17300	COG0438	transferase activity, transferring glycosyl groups
D9623_RS17325	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D9623_RS17335	COG0288	reversible hydration of carbon dioxide
D9623_RS17345	COG4948	Mandelate Racemase Muconate Lactonizing
D9623_RS17350	COG0583	DNA-binding transcription factor activity
D9623_RS17355	COG0625	glutathione transferase activity
D9623_RS17420	COG1335	isochorismatase
D9623_RS17425	COG4191	Histidine kinase
D9623_RS17430	COG4566	intracellular signal transduction
D9623_RS17475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D9623_RS17500	COG1132	(ABC) transporter
D9623_RS17515	COG1120	ATPase activity
D9623_RS17520	COG4774	siderophore transport
D9623_RS17530	COG0583	DNA-binding transcription factor activity
D9623_RS17535	COG2814	Major facilitator Superfamily
D9623_RS17565	COG0657	acetylesterase activity
D9623_RS17570	COG2423	ornithine cyclodeaminase activity
D9623_RS17575	COG0840	transmembrane signaling receptor activity
D9623_RS17610	COG0765	amino acid transport
D9623_RS17615	COG0765	amino acid transport
D9623_RS17640	COG2879	small protein
D9623_RS17645	COG1966	Carbon starvation protein
D9623_RS17675	COG1609	Transcriptional regulator
D9623_RS17680	COG4221	oxidoreductase activity
D9623_RS17695	COG1024	Enoyl-CoA hydratase
D9623_RS17715	COG1175	transmembrane transport
D9623_RS17725	COG3842	ATPase activity
D9623_RS17755	COG0683	leucine binding
D9623_RS17790	COG4615	Cyclic peptide transporter
D9623_RS17830	COG1320	monovalent cation:proton antiporter activity
D9623_RS17835	COG2212	antiporter activity
D9623_RS17840	COG1863	multisubunit Na H antiporter MnhE subunit
D9623_RS17845	COG0651	ATP synthesis coupled electron transport
D9623_RS17850	COG1006	Multisubunit Na H antiporter MnhC subunit
D9623_RS17855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D9623_RS17855	COG2111	Na H antiporter
D9623_RS17865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D9623_RS17870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D9623_RS17875	COG2091	lysine biosynthetic process via aminoadipic acid
D9623_RS17885	COG2027	D-alanyl-D-alanine carboxypeptidase
D9623_RS17915	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D9623_RS17925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D9623_RS17935	COG0840	transmembrane signaling receptor activity
D9623_RS17950	COG0745	RESPONSE REGULATOR receiver
D9623_RS17955	COG2205	protein histidine kinase activity
D9623_RS17960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D9623_RS17965	COG2864	formate dehydrogenase
D9623_RS17970	COG0437	4 iron, 4 sulfur cluster binding
D9623_RS17975	COG0243	molybdopterin cofactor binding
D9623_RS17975	COG3383	formate dehydrogenase (NAD+) activity
D9623_RS17995	COG0235	Class ii aldolase
D9623_RS18000	COG1942	4-Oxalocrotonate Tautomerase
D9623_RS18020	COG0420	3'-5' exonuclease activity
D9623_RS18030	COG3591	Belongs to the peptidase S1B family
D9623_RS18040	COG1192	Involved in chromosome partitioning
D9623_RS18045	COG1475	DNA binding
D9623_RS18060	COG0583	DNA-binding transcription factor activity
D9623_RS18065	COG0251	oxidation-reduction process
D9623_RS18080	COG3707	response regulator
D9623_RS18085	COG1116	anion transmembrane transporter activity
D9623_RS18095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9623_RS18100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9623_RS18105	COG2146	nitrite reductase [NAD(P)H] activity
D9623_RS18110	COG0243	molybdopterin cofactor binding
D9623_RS18115	COG1648	precorrin-2 dehydrogenase activity
D9623_RS18115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D9623_RS18120	COG0791	NLP P60 protein
D9623_RS18130	COG1032	radical SAM domain protein
D9623_RS18180	COG1609	Transcriptional regulator
D9623_RS18185	COG0583	DNA-binding transcription factor activity
D9623_RS18200	COG3195	allantoin biosynthetic process
D9623_RS18200	COG3648	Uricase
D9623_RS18210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_RS18230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D9623_RS18270	COG0243	molybdopterin cofactor binding
D9623_RS18270	COG3383	formate dehydrogenase (NAD+) activity
D9623_RS18275	COG0437	4 iron, 4 sulfur cluster binding
D9623_RS18280	COG2864	formate dehydrogenase
D9623_RS18285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_RS18310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_RS18320	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS18405	COG2223	nitrite transmembrane transporter activity
D9623_RS18440	COG1137	ATPase activity
D9623_RS18445	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D9623_RS18450	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D9623_RS18455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9623_RS18460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D9623_RS18465	COG0527	aspartate kinase activity
D9623_RS18470	COG2070	2-Nitropropane dioxygenase
D9623_RS18485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D9623_RS18490	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D9623_RS18500	COG2852	Protein conserved in bacteria
D9623_RS18505	COG2890	protein-(glutamine-N5) methyltransferase activity
D9623_RS18525	COG0542	response to heat
D9623_RS18530	COG1272	protein, Hemolysin III
D9623_RS18535	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D9623_RS18550	COG0840	transmembrane signaling receptor activity
D9623_RS18555	COG5265	(ABC) transporter
D9623_RS18565	COG1703	isobutyryl-CoA mutase activity
D9623_RS18575	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D9623_RS18585	COG2137	regulation of response to DNA damage stimulus
D9623_RS18590	COG0842	Transport permease protein
D9623_RS18595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D9623_RS18600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D9623_RS18615	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D9623_RS18620	COG0671	phosphoesterase, PA-phosphatase related
D9623_RS18635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D9623_RS18640	COG4774	siderophore transport
D9623_RS18645	COG3128	pkhd-type hydroxylase
D9623_RS18665	COG4604	ABC transporter, ATP-binding protein
D9623_RS18670	COG4605	iron ion homeostasis
D9623_RS18675	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9623_RS18680	COG4607	ABC-type enterochelin transport system periplasmic component
D9623_RS18685	COG1695	Transcriptional regulator
D9623_RS18700	COG0784	Response regulator, receiver
D9623_RS18700	COG2205	protein histidine kinase activity
D9623_RS18700	COG5002	protein histidine kinase activity
D9623_RS18760	COG4206	TonB-dependent receptor
D9623_RS18805	COG3685	Protein conserved in bacteria
D9623_RS18840	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D9623_RS18850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9623_RS18855	COG1959	2 iron, 2 sulfur cluster binding
D9623_RS18865	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D9623_RS18875	COG4208	sulfate ABC transporter
D9623_RS18915	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D9623_RS18920	COG0367	asparagine synthase
D9623_RS18925	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_RS18945	COG0438	transferase activity, transferring glycosyl groups
D9623_RS18950	COG0438	transferase activity, transferring glycosyl groups
D9623_RS18955	COG1215	transferase activity, transferring glycosyl groups
D9623_RS18980	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D9623_RS18990	COG3693	PFAM glycoside hydrolase, family 10
D9623_RS19000	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D9623_RS19010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D9623_RS19015	COG0588	phosphoglycerate mutase activity
D9623_RS19055	COG2011	ABC-type metal ion transport system permease component
D9623_RS19060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D9623_RS19065	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_RS19070	COG1464	Belongs to the NlpA lipoprotein family
D9623_RS19090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D9623_RS19100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D9623_RS19115	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D9623_RS19125	COG1530	ribonuclease E activity
D9623_RS19130	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D9623_RS19160	COG1192	Involved in chromosome partitioning
D9623_RS19165	COG1522	sequence-specific DNA binding
D9623_RS19175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D9623_RS19190	COG1309	transcriptional regulator
D9623_RS19205	COG5507	3-demethylubiquinone-9 3-methyltransferase
D9623_RS19215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D9623_RS19220	COG1012	belongs to the aldehyde dehydrogenase family
D9623_RS19225	COG1396	sequence-specific DNA binding
D9623_RS19225	COG1917	Cupin 2, conserved barrel domain protein
D9623_RS19235	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_RS19240	COG2182	Extracellular solute-binding protein
D9623_RS19245	COG3842	ATPase activity
D9623_RS19250	COG0583	DNA-binding transcription factor activity
D9623_RS19260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D9623_RS19290	COG0471	metal ion transport
D9623_RS19290	COG3273	potassium ion transport
D9623_RS19300	COG2814	Major facilitator Superfamily
D9623_RS19305	COG0583	DNA-binding transcription factor activity
D9623_RS19315	COG1566	PFAM secretion protein HlyD family protein
D9623_RS19355	COG4520	surface antigen
D9623_RS19360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9623_RS19375	COG0789	Transcriptional regulator
D9623_RS19380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D9623_RS19390	COG2860	membrane
D9623_RS19395	COG1741	Belongs to the pirin family
D9623_RS19420	COG2217	Heavy metal translocating P-type atpase
D9623_RS19435	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D9623_RS19450	COG0521	Mo-molybdopterin cofactor biosynthetic process
D9623_RS19455	COG0741	lytic transglycosylase activity
D9623_RS19460	COG1573	uracil-dna glycosylase
D9623_RS19485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_RS19535	COG4520	surface antigen
D9623_RS19600	COG0583	DNA-binding transcription factor activity
D9623_RS19610	COG1283	sodium-dependent phosphate transmembrane transporter activity
D9623_RS19635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_RS19670	COG0306	phosphate transporter
D9623_RS19675	COG1392	Phosphate transport regulator
D9623_RS19685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D9623_RS19695	COG2223	nitrite transmembrane transporter activity
D9623_RS19730	COG0612	Peptidase, M16
D9623_RS19740	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D9623_RS19760	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D9623_RS19770	COG0488	(ABC) transporter
D9623_RS19785	COG2249	NAD(P)H dehydrogenase (quinone) activity
D9623_RS19790	COG0583	DNA-binding transcription factor activity
D9623_RS19795	COG3135	benzoate transporter
D9623_RS19805	COG0505	Belongs to the CarA family
D9623_RS19810	COG0586	Pfam SNARE associated Golgi protein
D9623_RS19855	COG2884	Cell division ATP-binding protein ftsE
D9623_RS19890	COG5001	Diguanylate cyclase
D9623_RS19895	COG1381	Involved in DNA repair and RecF pathway recombination
D9623_RS19900	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D9623_RS19905	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D9623_RS19910	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D9623_RS19910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_RS19920	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D9623_RS19930	COG2308	Evidence 4 Homologs of previously reported genes of
D9623_RS19935	COG1360	Flagellar Motor Protein
D9623_RS19940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D9623_RS19945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D9623_RS19970	COG0784	Response regulator, receiver
D9623_RS19970	COG2198	Histidine kinase
D9623_RS19970	COG0643	Histidine kinase
D9623_RS19975	COG0835	chemotaxis
D9623_RS19980	COG0643	Histidine kinase
D9623_RS19980	COG0784	Response regulator, receiver
D9623_RS19980	COG2198	Histidine kinase
D9623_RS19995	COG0583	DNA-binding transcription factor activity
D9623_RS20005	COG0745	RESPONSE REGULATOR receiver
D9623_RS20025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D9623_RS20040	COG0552	protein localization to endoplasmic reticulum
D9623_RS20045	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9623_RS20050	COG2204	response regulator
D9623_RS20055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D9623_RS20060	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9623_RS20070	COG1766	The M ring may be actively involved in energy transduction
D9623_RS20075	COG1396	sequence-specific DNA binding
D9623_RS20085	COG2205	protein histidine kinase activity
D9623_RS20090	COG2373	Large extracellular alpha-helical protein
D9623_RS20110	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9623_RS20110	COG1024	Enoyl-CoA hydratase
D9623_RS20115	COG1960	acyl-CoA dehydrogenase activity
D9623_RS20130	COG3047	cAMP biosynthetic process
D9623_RS20145	COG1196	nuclear chromosome segregation
D9623_RS20160	COG1194	a g-specific adenine glycosylase
D9623_RS20180	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D9623_RS20190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_RS20190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9623_RS20195	COG3012	SEC-C Motif Domain Protein
D9623_RS20205	COG0793	Belongs to the peptidase S41A family
D9623_RS20215	COG0309	Hydrogenase expression formation protein (HypE)
D9623_RS20220	COG0298	carbon dioxide binding
D9623_RS20225	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D9623_RS20230	COG1280	lysine exporter protein (LysE YggA)
D9623_RS20240	COG0375	protein maturation
D9623_RS20255	COG0298	carbon dioxide binding
D9623_RS20275	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D9623_RS20280	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D9623_RS20285	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D9623_RS20290	COG5557	Pfam Polysulphide reductase, NrfD
D9623_RS20295	COG0437	4 iron, 4 sulfur cluster binding
D9623_RS20300	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D9623_RS20315	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D9623_RS20345	COG0625	glutathione transferase activity
D9623_RS20350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9623_RS20370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D9623_RS20370	COG2813	Specifically methylates the guanine in position
D9623_RS20375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D9623_RS20385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D9623_RS20390	COG0287	Prephenate dehydrogenase
D9623_RS20395	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D9623_RS20405	COG0583	DNA-binding transcription factor activity
D9623_RS20415	COG3634	alkyl hydroperoxide reductase activity
D9623_RS20420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D9623_RS20425	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D9623_RS20430	COG2080	2 iron, 2 sulfur cluster binding
D9623_RS20440	COG1988	membrane-bound metal-dependent
D9623_RS20460	COG0745	RESPONSE REGULATOR receiver
D9623_RS20470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9623_RS20475	COG0540	Belongs to the ATCase OTCase family
D9623_RS20490	COG0583	DNA-binding transcription factor activity
D9623_RS20520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D9623_RS20530	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D9623_RS20535	COG0154	amidase activity
D9623_RS20540	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D9623_RS20545	COG4191	Histidine kinase
D9623_RS20575	COG1794	racemase activity, acting on amino acids and derivatives
D9623_RS20585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D9623_RS20590	COG4770	biotin carboxylase activity
D9623_RS20595	COG1268	BioY protein
D9623_RS20600	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D9623_RS20600	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D9623_RS20615	COG2204	response regulator
D9623_RS20620	COG4191	Histidine kinase
D9623_RS20625	COG1301	dicarboxylic acid transport
D9623_RS20630	COG0281	malic enzyme
D9623_RS20630	COG0280	phosphate acetyltransferase
D9623_RS20635	COG0859	PFAM glycosyl transferase family 9
D9623_RS20635	COG0457	Tetratricopeptide repeat
D9623_RS20645	COG2995	paraquat-inducible protein a
D9623_RS20650	COG3008	intermembrane lipid transfer
D9623_RS20650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D9623_RS20660	COG1882	Formate acetyltransferase
D9623_RS20670	COG0277	FAD linked oxidase domain protein
D9623_RS20685	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D9623_RS20700	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D9623_RS20705	COG0567	Dehydrogenase, E1 component
D9623_RS20725	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D9623_RS20845	COG0714	Associated with various cellular activities
D9623_RS20865	COG0617	tRNA 3'-terminal CCA addition
D9623_RS20870	COG0408	coproporphyrinogen oxidase activity
D9623_RS20875	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D9623_RS20890	COG2857	Cytochrome c1
D9623_RS20890	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D9623_RS20910	COG0640	Transcriptional regulator
D9623_RS20920	COG0425	Belongs to the sulfur carrier protein TusA family
D9623_RS20940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D9623_RS20950	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D9623_RS20965	COG0583	DNA-binding transcription factor activity
D9623_RS20975	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS20980	COG1846	Transcriptional regulator
D9623_RS20990	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D9623_RS21000	COG0583	DNA-binding transcription factor activity
D9623_RS21015	COG0300	oxidoreductase activity
D9623_RS21050	COG1396	sequence-specific DNA binding
D9623_RS21065	COG3284	Transcriptional regulator
D9623_RS21070	COG3199	ATP-NAD kinase
D9623_RS21075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D9623_RS21080	COG0022	dehydrogenase e1 component
D9623_RS21085	COG0596	Alpha beta hydrolase
D9623_RS21085	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9623_RS21105	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS21110	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_RS21130	COG1082	Xylose isomerase domain protein TIM barrel
D9623_RS21140	COG0183	Belongs to the thiolase family
D9623_RS21180	COG1595	DNA-templated transcription, initiation
D9623_RS21185	COG3806	Anti-sigma factor
D9623_RS21190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9623_RS21350	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D9623_RS21430	COG0583	DNA-binding transcription factor activity
D9623_RS21450	COG0667	Aldo Keto reductase
D9623_RS21455	COG0583	DNA-binding transcription factor activity
D9623_RS21495	COG2703	oxygen carrier activity
D9623_RS21510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9623_RS21515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D9623_RS21520	COG1127	ABC transporter
D9623_RS21540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D9623_RS21545	COG1271	oxidase subunit
D9623_RS21550	COG1294	oxidase, subunit
D9623_RS21580	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS21605	COG2089	acid synthase
D9623_RS21610	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
D9623_RS21640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9623_RS21655	COG2703	oxygen carrier activity
D9623_RS21660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9623_RS21690	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D9623_RS21700	COG2030	dehydratase
D9623_RS21705	COG0196	riboflavin kinase activity
D9623_RS21710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D9623_RS21715	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D9623_RS21725	COG0859	PFAM glycosyl transferase family 9
D9623_RS21725	COG0457	Tetratricopeptide repeat
D9623_RS21730	COG0457	Tetratricopeptide repeat
D9623_RS21730	COG0859	PFAM glycosyl transferase family 9
D9623_RS21745	COG0859	PFAM glycosyl transferase family 9
D9623_RS21745	COG0457	Tetratricopeptide repeat
D9623_RS21765	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9623_RS21795	COG0784	Response regulator, receiver
D9623_RS21825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D9623_RS21835	COG1228	amidohydrolase
D9623_RS21850	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D9623_RS21865	COG2226	methyltransferase
D9623_RS21880	COG0747	negative chemotaxis
D9623_RS21885	COG0601	transmembrane transport
D9623_RS21890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9623_RS21895	COG0444	Belongs to the ABC transporter superfamily
D9623_RS21900	COG4608	Belongs to the ABC transporter superfamily
D9623_RS21935	COG1666	GTP binding
D9623_RS21960	COG5001	Diguanylate cyclase
D9623_RS21990	COG1752	Esterase of the alpha-beta hydrolase superfamily
D9623_RS21995	COG1132	(ABC) transporter
D9623_RS22000	COG4191	Histidine kinase
D9623_RS22025	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D9623_RS22035	COG2264	protein methyltransferase activity
D9623_RS22040	COG0583	DNA-binding transcription factor activity
D9623_RS22045	COG0655	NAD(P)H dehydrogenase (quinone) activity
D9623_RS22050	COG0435	Glutathione S-transferase
D9623_RS22060	COG2197	response regulator
D9623_RS22070	COG0492	ferredoxin-NADP+ reductase activity
D9623_RS22090	COG0484	heat shock protein binding
D9623_RS22100	COG0501	Belongs to the peptidase M48B family
D9623_RS22110	COG3038	cytochrome b561
D9623_RS22115	COG3240	lipase activity
D9623_RS22130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9623_RS22140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D9623_RS22150	COG1846	Transcriptional regulator
D9623_RS22160	COG3920	Histidine kinase
D9623_RS22180	COG1758	RNA polymerase activity
D9623_RS22195	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D9623_RS22200	COG0736	holo-[acyl-carrier-protein] synthase activity
D9623_RS22205	COG0681	Belongs to the peptidase S26 family
D9623_RS22210	COG0571	ribonuclease III activity
D9623_RS22215	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D9623_RS22220	COG3106	COG3106 Predicted ATPase
D9623_RS22225	COG3768	UPF0283 membrane protein
D9623_RS22245	COG0740	serine-type endopeptidase activity
D9623_RS22250	COG1216	Glycosyl transferase, family 2
D9623_RS22255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D9623_RS22260	COG1566	PFAM secretion protein HlyD family protein
D9623_RS22265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_RS22275	COG0183	Belongs to the thiolase family
D9623_RS22280	COG1960	acyl-CoA dehydrogenase activity
D9623_RS22290	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_RS22325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9623_RS22330	COG0747	negative chemotaxis
D9623_RS22340	COG2201	protein-glutamate methylesterase activity
D9623_RS22360	COG4771	TonB-dependent receptor
D9623_RS22385	COG1169	isochorismate synthase
D9623_RS22390	COG1021	2,3-dihydroxybenzoate-AMP ligase
D9623_RS22395	COG1535	isochorismatase
D9623_RS22395	COG3433	isochorismatase activity
D9623_RS22400	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS22410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9623_RS22415	COG2382	esterase
D9623_RS22425	COG1960	acyl-CoA dehydrogenase activity
D9623_RS22430	COG2186	Transcriptional regulator
D9623_RS22435	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_RS22440	COG1309	transcriptional regulator
D9623_RS22450	COG1846	Transcriptional regulator
D9623_RS22455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D9623_RS22465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_RS22485	COG2226	methyltransferase
D9623_RS22550	COG0861	Integral membrane protein TerC family
D9623_RS22560	COG0517	IMP dehydrogenase activity
D9623_RS22560	COG0617	tRNA 3'-terminal CCA addition
D9623_RS22560	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D9623_RS22565	COG1802	Transcriptional regulator
D9623_RS22605	COG0367	asparagine synthase
D9623_RS22610	COG2918	glutathione biosynthetic process
D9623_RS22610	COG1181	Belongs to the D-alanine--D-alanine ligase family
D9623_RS22615	COG1363	Peptidase, m42
D9623_RS22625	COG1966	Carbon starvation protein
D9623_RS22640	COG3275	phosphorelay sensor kinase activity
D9623_RS22680	COG0848	biopolymer transport protein
D9623_RS22690	COG4566	intracellular signal transduction
D9623_RS22695	COG4191	Histidine kinase
D9623_RS22700	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D9623_RS22740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_RS22750	COG5002	protein histidine kinase activity
D9623_RS22750	COG0784	Response regulator, receiver
D9623_RS22750	COG2205	protein histidine kinase activity
D9623_RS22775	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS22780	COG2890	protein-(glutamine-N5) methyltransferase activity
D9623_RS22800	COG0542	response to heat
D9623_RS22810	COG0402	S-adenosylhomocysteine deaminase activity
D9623_RS22815	COG1116	anion transmembrane transporter activity
D9623_RS22820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_RS22840	COG3842	ATPase activity
D9623_RS22850	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_RS22860	COG2351	hydroxyisourate hydrolase activity
D9623_RS22870	COG0154	amidase activity
D9623_RS22875	COG0784	Response regulator, receiver
D9623_RS22875	COG5002	protein histidine kinase activity
D9623_RS22915	COG3387	PFAM Glycoside hydrolase 15-related
D9623_RS22925	COG2197	response regulator
D9623_RS22930	COG2197	response regulator
D9623_RS22945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D9623_RS22950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9623_RS22955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9623_RS22960	COG0438	transferase activity, transferring glycosyl groups
D9623_RS22980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9623_RS23000	COG0438	transferase activity, transferring glycosyl groups
D9623_RS23015	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D9623_RS23030	COG0583	DNA-binding transcription factor activity
D9623_RS23035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_RS23050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9623_RS23055	COG4172	Belongs to the ABC transporter superfamily
D9623_RS23075	COG0028	Belongs to the TPP enzyme family
D9623_RS23080	COG3246	L-lysine catabolic process to acetate
D9623_RS23100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_RS23105	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_RS23115	COG1850	ribulose-bisphosphate carboxylase activity
D9623_RS23125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_RS23130	COG2204	response regulator
D9623_RS23185	COG4459	periplasmic nitrate reductase
D9623_RS23210	COG3005	denitrification pathway
D9623_RS23245	COG1845	cytochrome c oxidase, subunit III
D9623_RS23250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9623_RS23255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9623_RS23260	COG0477	Major facilitator Superfamily
D9623_RS23270	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D9623_RS23300	COG0392	lysyltransferase activity
D9623_RS23305	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D9623_RS23360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D9623_RS23380	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D9623_RS23385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_RS23405	COG1846	Transcriptional regulator
D9623_RS23410	COG1764	response to oxidative stress
D9623_RS23430	COG2113	Glycine betaine
D9623_RS23435	COG4176	ABC-type proline glycine betaine transport system permease component
D9623_RS23440	COG4175	Glycine betaine
D9623_RS23445	COG0339	signal peptide processing
D9623_RS23470	COG1522	sequence-specific DNA binding
D9623_RS23475	COG0251	oxidation-reduction process
D9623_RS23480	COG4336	lyase activity
D9623_RS23485	COG0405	Gamma-glutamyltransferase
D9623_RS23490	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D9623_RS23495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_RS23520	COG1595	DNA-templated transcription, initiation
D9623_RS23525	COG4774	siderophore transport
D9623_RS23540	COG4774	siderophore transport
D9623_RS23560	COG1120	ATPase activity
D9623_RS23595	COG0431	NADPH-dependent FMN reductase
D9623_RS23600	COG0798	PFAM Bile acid sodium symporter
D9623_RS23630	COG3842	ATPase activity
D9623_RS23640	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_RS23650	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_RS23655	COG1024	Enoyl-CoA hydratase
D9623_RS23660	COG0604	alcohol dehydrogenase
D9623_RS23680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_RS23685	COG0765	amino acid transport
D9623_RS23735	COG0840	transmembrane signaling receptor activity
D9623_RS23740	COG4178	(ABC) transporter
D9623_RS23750	COG1475	DNA binding
D9623_RS23755	COG1192	Involved in chromosome partitioning
D9623_RS23780	COG3622	Belongs to the hyi family
D9623_RS23790	COG1215	transferase activity, transferring glycosyl groups
D9623_RS23805	COG3307	-O-antigen
D9623_RS23810	COG3206	protein involved in exopolysaccharide biosynthesis
D9623_RS23810	COG0489	protein tyrosine kinase activity
D9623_RS23840	COG1216	Glycosyl transferase, family 2
D9623_RS23910	COG0640	Transcriptional regulator
D9623_RS23915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9623_RS23935	COG0446	pyridine nucleotide-disulphide oxidoreductase
D9623_RS23945	COG4566	intracellular signal transduction
D9623_RS23960	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS23980	COG1994	Peptidase M50
D9623_RS23980	COG0517	IMP dehydrogenase activity
D9623_RS23990	COG1959	2 iron, 2 sulfur cluster binding
D9623_RS24000	COG1522	sequence-specific DNA binding
D9623_RS24010	COG0583	DNA-binding transcription factor activity
D9623_RS24015	COG1802	Transcriptional regulator
D9623_RS24020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_RS24030	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_RS24030	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D9623_RS24035	COG2354	Protein conserved in bacteria
D9623_RS24055	COG1418	mRNA catabolic process
D9623_RS24060	COG1131	(ABC) transporter
D9623_RS24065	COG0842	Transport permease protein
D9623_RS24070	COG3791	Glutathione-dependent formaldehyde-activating
D9623_RS24075	COG0154	amidase activity
D9623_RS24080	COG0154	amidase activity
D9623_RS24085	COG1335	isochorismatase
D9623_RS24090	COG0747	negative chemotaxis
D9623_RS24095	COG0601	transmembrane transport
D9623_RS24100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9623_RS24110	COG4608	Belongs to the ABC transporter superfamily
D9623_RS24115	COG1335	isochorismatase
D9623_RS24120	COG3180	Ammonia monooxygenase
D9623_RS24125	COG1802	Transcriptional regulator
D9623_RS24135	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D9623_RS24140	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D9623_RS24145	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D9623_RS24150	COG2205	protein histidine kinase activity
D9623_RS24175	COG0840	transmembrane signaling receptor activity
D9623_RS24180	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_RS24185	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_RS24190	COG3842	ATPase activity
D9623_RS24200	COG1024	Enoyl-CoA hydratase
D9623_RS24205	COG1414	Transcriptional regulator
D9623_RS24245	COG0583	DNA-binding transcription factor activity
D9623_RS24255	COG3800	Transcriptional regulator
D9623_RS24255	COG1396	sequence-specific DNA binding
D9623_RS24265	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9623_RS24285	COG2828	Protein conserved in bacteria
D9623_RS24370	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
D9623_RS24380	COG0189	ligase activity
D9623_RS24385	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
D9623_RS24395	COG0702	epimerase
D9623_RS24405	COG2154	pterin-4-alpha-carbinolamine dehydratase
D9623_RS24415	COG1229	Formylmethanofuran dehydrogenase subunit A
D9623_RS24420	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
D9623_RS24440	COG1131	(ABC) transporter
D9623_RS24500	COG2010	Cytochrome c
D9623_RS24525	COG1573	uracil-dna glycosylase
D9623_RS24545	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D9623_RS24555	COG0583	DNA-binding transcription factor activity
D9623_RS24580	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS24625	COG1764	response to oxidative stress
D9623_RS24630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9623_RS24635	COG1960	acyl-CoA dehydrogenase activity
D9623_RS24640	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D9623_RS24715	COG0668	transmembrane transport
D9623_RS24755	COG1139	Iron-sulfur cluster binding protein
D9623_RS24760	COG0247	lactate metabolic process
D9623_RS24765	COG0277	FAD linked oxidase domain protein
D9623_RS24770	COG1620	l-lactate permease
D9623_RS24775	COG2186	Transcriptional regulator
D9623_RS24785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D9623_RS24790	COG0542	response to heat
D9623_RS24795	COG1414	Transcriptional regulator
D9623_RS24800	COG3734	2-keto-3-deoxy-galactonokinase
D9623_RS24805	COG0800	Aldolase
D9623_RS24835	COG0861	Integral membrane protein TerC family
D9623_RS24845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_RS24850	COG2353	YceI-like domain
D9623_RS24875	COG4566	intracellular signal transduction
D9623_RS24880	COG4566	intracellular signal transduction
D9623_RS24885	COG4191	Histidine kinase
D9623_RS24900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_RS24905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_RS24910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_RS24920	COG0427	acetyl-CoA hydrolase
D9623_RS24945	COG0243	molybdopterin cofactor binding
D9623_RS25035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D9623_RS25045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_RS25050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_RS25060	COG0628	permease
D9623_RS25065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D9623_RS25075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D9623_RS25115	COG1653	transport
D9623_RS25130	COG3842	ATPase activity
D9623_RS25155	COG0840	transmembrane signaling receptor activity
D9623_RS25155	COG0840	transmembrane signaling receptor activity
D9623_RS25195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_RS25200	COG1473	amidohydrolase
D9623_RS25215	COG4122	O-methyltransferase activity
D9623_RS25245	COG1971	Probably functions as a manganese efflux pump
D9623_RS25250	COG0840	transmembrane signaling receptor activity
D9623_RS25250	COG3290	protein histidine kinase activity
D9623_RS25275	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS25280	COG0366	Alpha amylase catalytic
D9623_RS25285	COG2388	GCN5-related N-acetyl-transferase
D9623_RS25300	COG4191	Histidine kinase
D9623_RS25300	COG0784	Response regulator, receiver
D9623_RS25305	COG5002	protein histidine kinase activity
D9623_RS25305	COG0784	Response regulator, receiver
D9623_RS25365	COG4615	Cyclic peptide transporter
D9623_RS25385	COG0586	Pfam SNARE associated Golgi protein
D9623_RS25400	COG3842	ATPase activity
D9623_RS25410	COG0395	ABC-type sugar transport system, permease component
D9623_RS25425	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D9623_RS25430	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS25455	COG2095	MarC family integral membrane protein
D9623_RS25470	COG0840	transmembrane signaling receptor activity
D9623_RS25475	COG0835	chemotaxis
D9623_RS25480	COG2201	protein-glutamate methylesterase activity
D9623_RS25490	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D9623_RS25500	COG2198	Histidine kinase
D9623_RS25500	COG0643	Histidine kinase
D9623_RS25510	COG2197	response regulator
D9623_RS25525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_RS25535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9623_RS25565	COG2204	response regulator
D9623_RS25575	COG2985	domain, Protein
D9623_RS25590	COG3842	ATPase activity
D9623_RS25605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_RS25615	COG0251	oxidation-reduction process
D9623_RS25625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9623_RS25635	COG0747	negative chemotaxis
D9623_RS25645	COG0583	DNA-binding transcription factor activity
D9623_RS25655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9623_RS25660	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9623_RS25660	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9623_RS25665	COG1660	Displays ATPase and GTPase activities
D9623_RS25680	COG0642	Histidine kinase
D9623_RS25685	COG0745	RESPONSE REGULATOR receiver
D9623_RS25700	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D9623_RS25715	COG0739	heme binding
D9623_RS25735	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D9623_RS25755	COG1216	Glycosyl transferase, family 2
D9623_RS25755	COG1442	glycosyl transferase family 8
D9623_RS25765	COG4178	(ABC) transporter
D9623_RS25775	COG2723	6-phospho-beta-galactosidase activity
D9623_RS25780	COG2723	6-phospho-beta-galactosidase activity
D9623_RS25800	COG2819	hydrolase of the alpha beta superfamily
D9623_RS25830	COG4770	biotin carboxylase activity
D9623_RS25835	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D9623_RS25840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D9623_RS25845	COG1960	acyl-CoA dehydrogenase activity
D9623_RS25855	COG0604	alcohol dehydrogenase
D9623_RS25860	COG1024	Enoyl-CoA hydratase
D9623_RS25865	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_RS25875	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_RS25885	COG3842	ATPase activity
D9623_RS25915	COG0798	PFAM Bile acid sodium symporter
D9623_RS25920	COG0431	NADPH-dependent FMN reductase
D9623_RS25955	COG1120	ATPase activity
D9623_RS25975	COG4774	siderophore transport
D9623_RS25990	COG4774	siderophore transport
D9623_RS25995	COG1595	DNA-templated transcription, initiation
D9623_RS26020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_RS26025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D9623_RS26030	COG0405	Gamma-glutamyltransferase
D9623_RS26035	COG4336	lyase activity
D9623_RS26040	COG0251	oxidation-reduction process
D9623_RS26045	COG1522	sequence-specific DNA binding
D9623_RS26085	COG1749	Flagellar hook protein flgE
D9623_RS26090	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D9623_RS26105	COG0667	Aldo Keto reductase
D9623_RS26125	COG4772	TonB-dependent receptor
D9623_RS26150	COG4251	negative regulation of phosphorylation
D9623_RS26155	COG0745	RESPONSE REGULATOR receiver
D9623_RS26160	COG0745	RESPONSE REGULATOR receiver
D9623_RS26175	COG2080	2 iron, 2 sulfur cluster binding
D9623_RS26180	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D9623_RS26185	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D9623_RS26195	COG2814	Major facilitator Superfamily
D9623_RS26210	COG0583	DNA-binding transcription factor activity
D9623_RS26255	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9623_RS26260	COG1024	Enoyl-CoA hydratase
D9623_RS26265	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9623_RS26265	COG0022	dehydrogenase e1 component
D9623_RS26270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D9623_RS26280	COG0683	leucine binding
D9623_RS26310	COG4221	oxidoreductase activity
D9623_RS26315	COG2814	Major facilitator Superfamily
D9623_RS26330	COG4774	siderophore transport
D9623_RS26345	COG1802	Transcriptional regulator
D9623_RS26350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_RS26355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D9623_RS26360	COG4948	Mandelate Racemase Muconate Lactonizing
D9623_RS26365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_RS26375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D9623_RS26395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9623_RS26400	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_RS26405	COG3842	ATPase activity
D9623_RS26415	COG0277	FAD linked oxidase domain protein
D9623_RS26425	COG0842	Transport permease protein
D9623_RS26430	COG0842	Transport permease protein
D9623_RS26430	COG1129	ABC transporter
D9623_RS26435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_RS26440	COG1940	carbohydrate kinase activity
D9623_RS26450	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9623_RS26455	COG1879	ABC-type sugar transport system periplasmic component
D9623_RS26465	COG0673	inositol 2-dehydrogenase activity
D9623_RS26470	COG2115	Belongs to the xylose isomerase family
D9623_RS26475	COG1070	Carbohydrate kinase
D9623_RS26480	COG0583	DNA-binding transcription factor activity
D9623_RS26490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D9623_RS26490	COG1017	nitric oxide dioxygenase activity
D9623_RS26495	COG0625	glutathione transferase activity
D9623_RS26500	COG1802	Transcriptional regulator
D9623_RS26505	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_RS26525	COG1012	belongs to the aldehyde dehydrogenase family
D9623_RS26530	COG1024	Enoyl-CoA hydratase
D9623_RS26535	COG2186	Transcriptional regulator
D9623_RS26635	COG1136	(ABC) transporter
D9623_RS26635	COG0577	efflux transmembrane transporter activity
D9623_RS26640	COG0577	efflux transmembrane transporter activity
D9623_RS26640	COG1136	(ABC) transporter
D9623_RS26660	COG0523	cobalamin synthesis protein
D9623_RS26685	COG4977	sequence-specific DNA binding
D9623_RS26990	COG3772	lysozyme
D9623_RS27100	COG2814	Major facilitator Superfamily
D9623_RS27105	COG0683	leucine binding
D9623_RS27120	COG0411	ABC transporter
D9623_RS27135	COG4566	intracellular signal transduction
D9623_RS27135	COG0745	RESPONSE REGULATOR receiver
D9623_RS27145	COG1278	Cold shock
D9623_RS27150	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D9623_RS27155	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D9623_RS27170	COG2204	response regulator
D9623_RS27175	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9623_RS27180	COG3246	L-lysine catabolic process to acetate
D9623_RS27185	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS27195	COG1396	sequence-specific DNA binding
D9623_RS27215	COG3842	ATPase activity
D9623_RS27220	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_RS27225	COG1177	transmembrane transport
D9623_RS27245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_RS27250	COG0251	oxidation-reduction process
D9623_RS27260	COG0251	oxidation-reduction process
D9623_RS27265	COG0861	Integral membrane protein TerC family
D9623_RS27285	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_RS27285	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D9623_RS27290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_RS27295	COG3250	beta-galactosidase activity
D9623_RS27310	COG1783	phage Terminase large subunit
D9623_RS27385	COG2205	protein histidine kinase activity
D9623_RS27385	COG5002	protein histidine kinase activity
D9623_RS27385	COG0784	Response regulator, receiver
D9623_RS27400	COG1695	Transcriptional regulator
D9623_RS27405	COG4607	ABC-type enterochelin transport system periplasmic component
D9623_RS27410	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9623_RS27415	COG4605	iron ion homeostasis
D9623_RS27420	COG4604	ABC transporter, ATP-binding protein
D9623_RS27470	COG4302	ethanolamine ammonia-lyase activity
D9623_RS27495	COG0515	serine threonine protein kinase
D9623_RS27495	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D9623_RS27505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_RS27510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_RS27525	COG0066	3-isopropylmalate dehydratase activity
D9623_RS27530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D9623_RS27535	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D9623_RS27540	COG1802	Transcriptional regulator
D9623_RS27545	COG3938	Belongs to the proline racemase family
D9623_RS27550	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_RS27555	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_RS27560	COG3842	ATPase activity
D9623_RS27605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D9623_RS27615	COG3436	PFAM IS66 Orf2 family protein
D9623_RS27665	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS27670	COG0583	DNA-binding transcription factor activity
D9623_RS27675	COG1846	Transcriptional regulator
D9623_RS27680	COG1764	response to oxidative stress
D9623_RS27685	COG0596	Alpha beta hydrolase
D9623_RS27785	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D9623_RS27810	COG1595	DNA-templated transcription, initiation
D9623_RS27815	COG3712	iron ion homeostasis
D9623_RS27825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_RS27830	COG0577	efflux transmembrane transporter activity
D9623_RS27830	COG1136	(ABC) transporter
D9623_RS27845	COG1121	(ABC) transporter
D9623_RS27875	COG2188	Transcriptional regulator
D9623_RS27890	COG0697	spore germination
D9623_RS27905	COG1595	DNA-templated transcription, initiation
D9623_RS27925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9623_RS27945	COG0154	amidase activity
D9623_RS27950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D9623_RS27955	COG1024	Enoyl-CoA hydratase
D9623_RS27965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_RS27980	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS28020	COG1959	2 iron, 2 sulfur cluster binding
D9623_RS28155	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D9623_RS28160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D9623_RS28190	COG0633	Ferredoxin
D9623_RS28195	COG2124	cytochrome p450
D9623_RS28210	COG0583	DNA-binding transcription factor activity
D9623_RS28235	COG2271	Major facilitator Superfamily
D9623_RS28240	COG0583	DNA-binding transcription factor activity
D9623_RS28270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_RS28285	COG0826	peptidase U32
D9623_RS28310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9623_RS28325	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D9623_RS28340	COG4263	nitrous-oxide reductase activity
D9623_RS28360	COG0714	Associated with various cellular activities
D9623_RS28365	COG3256	nitric oxide reductase
D9623_RS28390	COG2223	nitrite transmembrane transporter activity
D9623_RS28440	COG0489	protein tyrosine kinase activity
D9623_RS28450	COG4964	Belongs to the GSP D family
D9623_RS28485	COG1278	Cold shock
D9623_RS28495	COG0513	Belongs to the DEAD box helicase family
D9623_RS28520	COG3842	ATPase activity
D9623_RS28550	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS28570	COG2610	gluconate transmembrane transporter activity
D9623_RS28600	COG3920	Histidine kinase
D9623_RS28630	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_RS28635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D9623_RS28650	COG0071	Belongs to the small heat shock protein (HSP20) family
D9623_RS28660	COG1802	Transcriptional regulator
D9623_RS28660	COG4626	Terminase
D9623_RS28700	COG1126	abc transporter atp-binding protein
D9623_RS28750	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D9623_RS28770	COG0356	it plays a direct role in the translocation of protons across the membrane
D9623_RS28780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9623_RS28785	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D9623_RS28790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D9623_RS28800	COG1566	PFAM secretion protein HlyD family protein
D9623_RS28815	COG2207	Transcriptional regulator
D9623_RS28830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_RS28840	COG0765	amino acid transport
D9623_RS28845	COG1126	abc transporter atp-binding protein
D9623_RS28850	COG1012	belongs to the aldehyde dehydrogenase family
D9623_RS28860	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D9623_RS28870	COG2721	sulfolactate sulfo-lyase activity
D9623_RS28895	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D9623_RS28915	COG1414	Transcriptional regulator
D9623_RS28925	COG0601	transmembrane transport
D9623_RS28930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9623_RS28935	COG0444	Belongs to the ABC transporter superfamily
D9623_RS28940	COG4608	Belongs to the ABC transporter superfamily
D9623_RS28955	COG4302	ethanolamine ammonia-lyase activity
D9623_RS28960	COG4303	Ethanolamine ammonia lyase large subunit
D9623_RS28965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_RS28990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9623_RS29000	COG0859	PFAM glycosyl transferase family 9
D9623_RS29000	COG0457	Tetratricopeptide repeat
D9623_RS29035	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_RS29070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9623_RS29075	COG0747	negative chemotaxis
D9623_RS29085	COG2201	protein-glutamate methylesterase activity
D9623_RS29105	COG4771	TonB-dependent receptor
D9623_RS29130	COG1169	isochorismate synthase
D9623_RS29135	COG1021	2,3-dihydroxybenzoate-AMP ligase
D9623_RS29140	COG1535	isochorismatase
D9623_RS29140	COG3433	isochorismatase activity
D9623_RS29145	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS29155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9623_RS29160	COG2382	esterase
D9623_RS29170	COG1960	acyl-CoA dehydrogenase activity
D9623_RS29175	COG2186	Transcriptional regulator
D9623_RS29180	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_RS29185	COG1309	transcriptional regulator
D9623_RS29195	COG1846	Transcriptional regulator
D9623_RS29200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D9623_RS29210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_RS29230	COG2226	methyltransferase
D9623_RS29320	COG0277	FAD linked oxidase domain protein
D9623_RS29335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D9623_RS29350	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D9623_RS29355	COG0567	Dehydrogenase, E1 component
D9623_RS29380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D9623_RS29385	COG1845	cytochrome c oxidase, subunit III
D9623_RS29395	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D9623_RS29405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9623_RS29410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9623_RS29415	COG1120	ATPase activity
D9623_RS29420	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D9623_RS29425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D9623_RS29440	COG1802	Transcriptional regulator
D9623_RS29445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9623_RS29470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D9623_RS29480	COG5443	negative regulation of bacterial-type flagellum assembly
D9623_RS29500	COG2814	Major facilitator Superfamily
D9623_RS29520	COG1815	bacterial-type flagellum-dependent cell motility
D9623_RS29525	COG1558	bacterial-type flagellum-dependent cell motility
D9623_RS29530	COG1677	Flagellar hook-basal body complex protein FliE
D9623_RS29540	COG4794	Type iii secretion
D9623_RS29550	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9623_RS29555	COG1684	flagellar biosynthetic protein fliR
D9623_RS29560	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9623_RS29570	COG1522	sequence-specific DNA binding
D9623_RS29580	COG0028	Belongs to the TPP enzyme family
D9623_RS29590	COG4191	Histidine kinase
D9623_RS29600	COG5487	UPF0391 membrane protein
D9623_RS29605	COG0793	Belongs to the peptidase S41A family
D9623_RS29610	COG0583	DNA-binding transcription factor activity
D9623_RS29615	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS29640	COG3300	MHYT domain
D9623_RS29640	COG5001	Diguanylate cyclase
D9623_RS29665	COG1706	bacterial-type flagellum-dependent cell motility
D9623_RS29680	COG1749	Flagellar hook protein flgE
D9623_RS29710	COG0861	Integral membrane protein TerC family
D9623_RS29715	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_RS29725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_RS29730	COG1802	Transcriptional regulator
D9623_RS29735	COG0697	spore germination
D9623_RS29740	COG2116	formate transmembrane transporter activity
D9623_RS29745	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D9623_RS29750	COG0469	pyruvate kinase activity
D9623_RS29760	COG4251	negative regulation of phosphorylation
D9623_RS29765	COG5002	protein histidine kinase activity
D9623_RS29770	COG1309	transcriptional regulator
D9623_RS29775	COG1309	transcriptional regulator
D9623_RS29780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_RS29785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_RS29790	COG0837	glucose binding
D9623_RS29790	COG1737	Transcriptional regulator
D9623_RS29795	COG1882	Formate acetyltransferase
D9623_RS29825	COG0861	Integral membrane protein TerC family
D9623_RS29835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_RS29840	COG2353	YceI-like domain
D9623_RS29865	COG4566	intracellular signal transduction
D9623_RS29870	COG4566	intracellular signal transduction
D9623_RS29875	COG4191	Histidine kinase
D9623_RS29890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_RS29895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_RS29900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_RS29910	COG0427	acetyl-CoA hydrolase
D9623_RS29935	COG0243	molybdopterin cofactor binding
D9623_RS30025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D9623_RS30035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_RS30040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_RS30050	COG0628	permease
D9623_RS30055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D9623_RS30065	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D9623_RS30105	COG1653	transport
D9623_RS30120	COG3842	ATPase activity
D9623_RS30145	COG0840	transmembrane signaling receptor activity
D9623_RS30145	COG0840	transmembrane signaling receptor activity
D9623_RS30185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_RS30190	COG1473	amidohydrolase
D9623_RS30205	COG4122	O-methyltransferase activity
D9623_RS30235	COG1971	Probably functions as a manganese efflux pump
D9623_RS30240	COG0840	transmembrane signaling receptor activity
D9623_RS30240	COG3290	protein histidine kinase activity
D9623_RS30265	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS30270	COG0366	Alpha amylase catalytic
D9623_RS30275	COG2388	GCN5-related N-acetyl-transferase
D9623_RS30290	COG0784	Response regulator, receiver
D9623_RS30290	COG4191	Histidine kinase
D9623_RS30295	COG5002	protein histidine kinase activity
D9623_RS30295	COG0784	Response regulator, receiver
D9623_RS30355	COG4615	Cyclic peptide transporter
D9623_RS30375	COG0586	Pfam SNARE associated Golgi protein
D9623_RS30390	COG3842	ATPase activity
D9623_RS30400	COG0395	ABC-type sugar transport system, permease component
D9623_RS30415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D9623_RS30420	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS30445	COG2095	MarC family integral membrane protein
D9623_RS30460	COG0840	transmembrane signaling receptor activity
D9623_RS30465	COG0835	chemotaxis
D9623_RS30470	COG2201	protein-glutamate methylesterase activity
D9623_RS30480	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D9623_RS30490	COG2198	Histidine kinase
D9623_RS30490	COG0643	Histidine kinase
D9623_RS30500	COG2197	response regulator
D9623_RS30515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_RS30525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9623_RS30555	COG2204	response regulator
D9623_RS30565	COG2985	domain, Protein
D9623_RS30580	COG3842	ATPase activity
D9623_RS30595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_RS30605	COG0251	oxidation-reduction process
D9623_RS30615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9623_RS30625	COG0747	negative chemotaxis
D9623_RS30635	COG0583	DNA-binding transcription factor activity
D9623_RS30645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9623_RS30650	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9623_RS30650	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9623_RS30655	COG1660	Displays ATPase and GTPase activities
D9623_RS30670	COG0642	Histidine kinase
D9623_RS30675	COG0745	RESPONSE REGULATOR receiver
D9623_RS30690	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D9623_RS30705	COG0739	heme binding
D9623_RS30755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D9623_RS30755	COG0596	Alpha beta hydrolase
D9623_RS30755	COG2226	methyltransferase
D9623_RS30760	COG0183	Belongs to the thiolase family
D9623_RS30765	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS30775	COG2814	Major facilitator Superfamily
D9623_RS30780	COG0583	DNA-binding transcription factor activity
D9623_RS30790	COG3300	MHYT domain
D9623_RS30790	COG5001	Diguanylate cyclase
D9623_RS30795	COG0012	GTP binding
D9623_RS30815	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9623_RS30815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9623_RS30840	COG1131	(ABC) transporter
D9623_RS30865	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9623_RS30865	COG2010	Cytochrome c
D9623_RS30870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9623_RS30885	COG1254	Belongs to the acylphosphatase family
D9623_RS30890	COG2233	PERMEase
D9623_RS30895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D9623_RS30900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9623_RS30910	COG1178	ABC-type Fe3 transport system permease component
D9623_RS30915	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_RS30920	COG3842	ATPase activity
D9623_RS30945	COG1045	serine acetyltransferase
D9623_RS30985	COG0784	Response regulator, receiver
D9623_RS30990	COG4251	negative regulation of phosphorylation
D9623_RS31015	COG0191	fructose-bisphosphate aldolase activity
D9623_RS31025	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D9623_RS31030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9623_RS31085	COG2022	thiamine diphosphate biosynthetic process
D9623_RS31095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_RS31095	COG2022	thiamine diphosphate biosynthetic process
D9623_RS31100	COG2239	Acts as a magnesium transporter
D9623_RS31130	COG0747	negative chemotaxis
D9623_RS31135	COG0601	transmembrane transport
D9623_RS31145	COG0444	Belongs to the ABC transporter superfamily
D9623_RS31150	COG4608	Belongs to the ABC transporter superfamily
D9623_RS31155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_RS31165	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS31175	COG1744	ABC transporter substrate-binding protein PnrA-like
D9623_RS31210	COG0484	heat shock protein binding
D9623_RS31220	COG0564	pseudouridine synthase activity
D9623_RS31235	COG0156	8-amino-7-oxononanoate synthase activity
D9623_RS31245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D9623_RS31245	COG4106	trans-aconitate 2-methyltransferase activity
D9623_RS31250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D9623_RS31255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D9623_RS31265	COG0574	Belongs to the PEP-utilizing enzyme family
D9623_RS31265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D9623_RS31275	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D9623_RS31280	COG1278	Cold shock
D9623_RS31285	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_RS31305	COG1496	oxidoreductase activity
D9623_RS31315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D9623_RS31320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D9623_RS31330	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9623_RS31335	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9623_RS31340	COG1129	ABC transporter
D9623_RS31345	COG1879	ABC-type sugar transport system periplasmic component
D9623_RS31385	COG4214	carbohydrate transport
D9623_RS31395	COG0129	dihydroxy-acid dehydratase activity
D9623_RS31410	COG0246	Mannitol dehydrogenase
D9623_RS31415	COG0725	ABC transporter, periplasmic molybdate-binding protein
D9623_RS31430	COG5039	Polysaccharide pyruvyl transferase
D9623_RS31435	COG2132	Multicopper oxidase
D9623_RS31445	COG1309	transcriptional regulator
D9623_RS31450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_RS31455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_RS31460	COG0702	epimerase
D9623_RS31465	COG1733	regulation of RNA biosynthetic process
D9623_RS31475	COG0583	DNA-binding transcription factor activity
D9623_RS31490	COG2133	pyrroloquinoline quinone binding
D9623_RS31510	COG1312	Catalyzes the dehydration of D-mannonate
D9623_RS31515	COG0246	Mannitol dehydrogenase
D9623_RS31530	COG1802	Transcriptional regulator
D9623_RS31535	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS31540	COG1917	Cupin 2, conserved barrel domain protein
D9623_RS31545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_RS31555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_RS31575	COG4774	siderophore transport
D9623_RS31580	COG0667	Aldo Keto reductase
D9623_RS31585	COG1802	Transcriptional regulator
D9623_RS31595	COG1904	glucuronate isomerase
D9623_RS31600	COG2721	sulfolactate sulfo-lyase activity
D9623_RS31635	COG0861	Integral membrane protein TerC family
D9623_RS31690	COG2188	Transcriptional regulator
D9623_RS31705	COG0154	amidase activity
D9623_RS31720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D9623_RS31725	COG1960	acyl-CoA dehydrogenase activity
D9623_RS31730	COG2079	MmgE PrpD family protein
D9623_RS31750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_RS31755	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS31770	COG1595	DNA-templated transcription, initiation
D9623_RS31840	COG1132	(ABC) transporter
D9623_RS31855	COG2203	Gaf domain
D9623_RS31855	COG2199	diguanylate cyclase activity
D9623_RS31875	COG0405	Gamma-glutamyltransferase
D9623_RS31905	COG1858	cytochrome C peroxidase
D9623_RS31925	COG4964	Belongs to the GSP D family
D9623_RS32025	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D9623_RS32050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D9623_RS32060	COG3845	ABC transporter
D9623_RS32065	COG4603	Belongs to the binding-protein-dependent transport system permease family
D9623_RS32070	COG1079	Belongs to the binding-protein-dependent transport system permease family
D9623_RS32075	COG0402	S-adenosylhomocysteine deaminase activity
D9623_RS32080	COG0840	transmembrane signaling receptor activity
D9623_RS32085	COG4191	Histidine kinase
D9623_RS32115	COG1414	Transcriptional regulator
D9623_RS32120	COG3383	formate dehydrogenase (NAD+) activity
D9623_RS32130	COG0028	Belongs to the TPP enzyme family
D9623_RS32145	COG1597	lipid kinase activity
D9623_RS32155	COG0628	permease
D9623_RS32160	COG3416	Protein conserved in bacteria
D9623_RS32205	COG1802	Transcriptional regulator
D9623_RS32210	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D9623_RS32215	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS32225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D9623_RS32245	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9623_RS32255	COG1338	Plays a role in the flagellum-specific transport system
D9623_RS32260	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9623_RS32270	COG1766	The M ring may be actively involved in energy transduction
D9623_RS32335	COG3005	denitrification pathway
D9623_RS32345	COG0243	molybdopterin cofactor binding
D9623_RS32365	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D9623_RS32370	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
D9623_RS32375	COG4786	Flagellar basal body rod
D9623_RS32380	COG4786	Flagellar basal body rod
D9623_RS32390	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D9623_RS32395	COG1360	Flagellar Motor Protein
D9623_RS32470	COG1012	belongs to the aldehyde dehydrogenase family
D9623_RS32470	COG1454	alcohol dehydrogenase
D9623_RS32525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9623_RS32555	COG4221	oxidoreductase activity
D9623_RS32570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_RS32575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9623_RS32580	COG0583	DNA-binding transcription factor activity
D9623_RS32585	COG0028	Belongs to the TPP enzyme family
D9623_RS32590	COG1012	belongs to the aldehyde dehydrogenase family
D9623_RS32615	COG0784	Response regulator, receiver
D9623_RS32615	COG4191	Histidine kinase
D9623_RS32620	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D9623_RS32655	COG0583	DNA-binding transcription factor activity
D9623_RS32660	COG2855	membrane
D9623_RS32685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9623_RS32705	COG0683	leucine binding
D9623_RS32735	COG3473	Maleate cis-trans isomerase
D9623_RS32740	COG0596	Alpha beta hydrolase
D9623_RS32745	COG2309	aminopeptidase activity
D9623_RS32750	COG1335	isochorismatase
D9623_RS32760	COG1609	Transcriptional regulator
D9623_RS32765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D9623_RS32765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9623_RS32770	COG1105	Belongs to the carbohydrate kinase PfkB family
D9623_RS32775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9623_RS32775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9623_RS32785	COG3920	Histidine kinase
D9623_RS32790	COG2197	response regulator
D9623_RS32825	COG0583	DNA-binding transcription factor activity
D9623_RS32840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_RS32845	COG1473	amidohydrolase
D9623_RS32885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D9623_RS32890	COG0251	oxidation-reduction process
D9623_RS32895	COG1522	sequence-specific DNA binding
D9623_RS32905	COG1414	Transcriptional regulator
D9623_RS32910	COG0280	phosphate acetyltransferase
D9623_RS32930	COG1012	belongs to the aldehyde dehydrogenase family
D9623_RS32935	COG0045	succinate-CoA ligase (ADP-forming) activity
D9623_RS32940	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D9623_RS32945	COG0243	molybdopterin cofactor binding
D9623_RS32950	COG0437	4 iron, 4 sulfur cluster binding
D9623_RS32965	COG0028	Belongs to the TPP enzyme family
D9623_RS32970	COG1475	DNA binding
D9623_RS32975	COG1192	Involved in chromosome partitioning
D9623_RS32995	COG0546	phosphoglycolate phosphatase activity
D9623_RS33010	COG0438	transferase activity, transferring glycosyl groups
D9623_RS33015	COG0500	methyltransferase
D9623_RS33020	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D9623_RS33025	COG0579	oxidoreductase
D9623_RS33030	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
D9623_RS33035	COG0297	glycogen (starch) synthase activity
D9623_RS33040	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D9623_RS33045	COG1088	dTDP-glucose 4,6-dehydratase activity
D9623_RS33065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_RS33080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9623_RS33100	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D9623_RS33105	COG3754	Rhamnan synthesis protein F
D9623_RS33170	COG0297	glycogen (starch) synthase activity
D9623_RS33180	COG1215	transferase activity, transferring glycosyl groups
D9623_RS33220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9623_RS33230	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D9623_RS33260	COG1192	Involved in chromosome partitioning
D9623_RS33265	COG1475	DNA binding
D9623_RS33275	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D9623_RS33290	COG1086	Polysaccharide biosynthesis protein
D9623_RS33300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D9623_RS33315	COG1051	belongs to the nudix hydrolase family
D9623_RS33335	COG0528	UMP kinase activity
D9623_RS33355	COG0861	Integral membrane protein TerC family
D9623_RS33360	COG0251	oxidation-reduction process
D9623_RS33370	COG0251	oxidation-reduction process
D9623_RS33375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_RS33395	COG1177	transmembrane transport
D9623_RS33400	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_RS33405	COG3842	ATPase activity
D9623_RS33425	COG1396	sequence-specific DNA binding
D9623_RS33435	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_RS33440	COG3246	L-lysine catabolic process to acetate
D9623_RS33445	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9623_RS33450	COG2204	response regulator
D9623_RS33465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D9623_RS33470	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D9623_RS33475	COG1278	Cold shock
D9623_RS33485	COG0745	RESPONSE REGULATOR receiver
D9623_RS33485	COG4566	intracellular signal transduction
D9623_RS33500	COG0411	ABC transporter
D9623_RS33515	COG0683	leucine binding
D9623_RS33520	COG2814	Major facilitator Superfamily
D9623_RS33630	COG3772	lysozyme
D9623_RS34035	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D9623_RS34040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D9623_RS34070	COG0633	Ferredoxin
D9623_RS34075	COG2124	cytochrome p450
D9623_RS34090	COG0583	DNA-binding transcription factor activity
D9623_RS34115	COG2271	Major facilitator Superfamily
D9623_RS34145	COG1088	dTDP-glucose 4,6-dehydratase activity
D9623_RS34165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D9623_RS34175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D9623_RS34195	COG0438	transferase activity, transferring glycosyl groups
D9623_RS34205	COG1216	Glycosyl transferase, family 2
D9623_RS34205	COG0438	transferase activity, transferring glycosyl groups
D9623_RS34215	COG0438	transferase activity, transferring glycosyl groups
D9623_RS34255	COG0463	Glycosyl transferase, family 2
D9623_RS34265	COG1215	transferase activity, transferring glycosyl groups
D9623_RS34270	COG0438	transferase activity, transferring glycosyl groups