locus-tag	class	description
D3868_RS00055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3868_RS00060	COG3845	ABC transporter
D3868_RS00065	COG4603	Belongs to the binding-protein-dependent transport system permease family
D3868_RS00070	COG1079	Belongs to the binding-protein-dependent transport system permease family
D3868_RS00105	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3868_RS00110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3868_RS00125	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS00130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3868_RS00135	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D3868_RS00145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D3868_RS00150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3868_RS00155	COG0351	phosphomethylpyrimidine kinase
D3868_RS00160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3868_RS00175	COG0670	Belongs to the BI1 family
D3868_RS00200	COG2030	dehydratase
D3868_RS00200	COG1012	belongs to the aldehyde dehydrogenase family
D3868_RS00205	COG0443	Heat shock 70 kDa protein
D3868_RS00230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D3868_RS00230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D3868_RS00280	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3868_RS00285	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3868_RS00295	COG0649	NAD binding
D3868_RS00300	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D3868_RS00310	COG1034	ATP synthesis coupled electron transport
D3868_RS00315	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D3868_RS00320	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3868_RS00330	COG0713	ATP synthesis coupled electron transport
D3868_RS00345	COG1007	ATP synthesis coupled electron transport
D3868_RS00365	COG0346	lactoylglutathione lyase activity
D3868_RS00375	COG0519	Catalyzes the synthesis of GMP from XMP
D3868_RS00390	COG0442	prolyl-tRNA aminoacylation
D3868_RS00425	COG0052	Belongs to the universal ribosomal protein uS2 family
D3868_RS00430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D3868_RS00435	COG0528	UMP kinase activity
D3868_RS00440	COG0233	cytoplasmic translational termination
D3868_RS00445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D3868_RS00455	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D3868_RS00460	COG0750	zinc metalloprotease
D3868_RS00480	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3868_RS00485	COG3494	Protein of unknown function (DUF1009)
D3868_RS00490	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3868_RS00505	COG0583	DNA-binding transcription factor activity
D3868_RS00520	COG0372	Belongs to the citrate synthase family
D3868_RS00525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3868_RS00530	COG0658	competence protein
D3868_RS00530	COG2333	competence protein COMEC
D3868_RS00535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D3868_RS00540	COG0303	'Molybdopterin
D3868_RS00545	COG0315	cyclic pyranopterin monophosphate synthase activity
D3868_RS00590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3868_RS00600	COG0149	triose-phosphate isomerase activity
D3868_RS00630	COG0535	radical SAM domain protein
D3868_RS00635	COG0535	radical SAM domain protein
D3868_RS00640	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
D3868_RS00645	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D3868_RS00655	COG0148	phosphopyruvate hydratase activity
D3868_RS00665	COG0037	tRNA processing
D3868_RS00700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_RS00720	COG0596	Alpha beta hydrolase
D3868_RS00725	COG0728	peptidoglycan biosynthetic process
D3868_RS00735	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3868_RS00750	COG0436	Aminotransferase
D3868_RS00770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_RS00775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3868_RS00790	COG0745	RESPONSE REGULATOR receiver
D3868_RS00805	COG0840	transmembrane signaling receptor activity
D3868_RS00835	COG2205	protein histidine kinase activity
D3868_RS00840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D3868_RS00870	COG1024	Enoyl-CoA hydratase
D3868_RS00880	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D3868_RS00885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D3868_RS00890	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D3868_RS00895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D3868_RS00900	COG2885	chlorophyll binding
D3868_RS00900	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D3868_RS00905	COG3243	poly(R)-hydroxyalkanoic acid synthase
D3868_RS00930	COG0436	Aminotransferase
D3868_RS00940	COG1494	fructose-1,6-bisphosphatase
D3868_RS00945	COG0371	Dehydrogenase
D3868_RS00950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D3868_RS00950	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D3868_RS01025	COG0656	L-ascorbic acid biosynthetic process
D3868_RS01050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3868_RS01055	COG0517	IMP dehydrogenase activity
D3868_RS01090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3868_RS01095	COG0045	succinate-CoA ligase (ADP-forming) activity
D3868_RS01105	COG2814	Major facilitator Superfamily
D3868_RS01120	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D3868_RS01135	COG2084	Dehydrogenase
D3868_RS01140	COG3622	Belongs to the hyi family
D3868_RS01145	COG3960	tartronate-semialdehyde synthase activity
D3868_RS01150	COG0352	thiamine-phosphate diphosphorylase activity
D3868_RS01150	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D3868_RS01155	COG1802	Transcriptional regulator
D3868_RS01160	COG0469	pyruvate kinase activity
D3868_RS01170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3868_RS01170	COG0574	Belongs to the PEP-utilizing enzyme family
D3868_RS01200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3868_RS01210	COG0693	protein deglycase activity
D3868_RS01215	COG2197	response regulator
D3868_RS01220	COG2197	response regulator
D3868_RS01235	COG0829	nickel cation binding
D3868_RS01240	COG0831	urea catabolic process
D3868_RS01245	COG0832	Belongs to the urease beta subunit family
D3868_RS01250	COG0804	urea catabolic process
D3868_RS01255	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D3868_RS01260	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D3868_RS01265	COG0830	nickel cation binding
D3868_RS01270	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D3868_RS01275	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
D3868_RS01285	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3868_RS01300	COG0640	Transcriptional regulator
D3868_RS01330	COG1396	sequence-specific DNA binding
D3868_RS01355	COG1846	Transcriptional regulator
D3868_RS01365	COG0704	Plays a role in the regulation of phosphate uptake
D3868_RS01385	COG0463	Glycosyl transferase, family 2
D3868_RS01405	COG1940	carbohydrate kinase activity
D3868_RS01455	COG2885	chlorophyll binding
D3868_RS01455	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D3868_RS01460	COG2197	response regulator
D3868_RS01465	COG0784	Response regulator, receiver
D3868_RS01465	COG2205	protein histidine kinase activity
D3868_RS01465	COG2198	Histidine kinase
D3868_RS01480	COG0564	pseudouridine synthase activity
D3868_RS01485	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS01490	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D3868_RS01505	COG0024	Methionine aminopeptidase
D3868_RS01520	COG1127	ABC transporter
D3868_RS01525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3868_RS01530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3868_RS01535	COG0305	Participates in initiation and elongation during chromosome replication
D3868_RS01540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3868_RS01545	COG0359	binds to the 23S rRNA
D3868_RS01555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D3868_RS01560	COG0360	Binds together with S18 to 16S ribosomal RNA
D3868_RS01565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D3868_RS01580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3868_RS01585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D3868_RS01595	COG0741	lytic transglycosylase activity
D3868_RS01600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3868_RS01605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D3868_RS01610	COG2813	Specifically methylates the guanine in position
D3868_RS01620	COG1881	PFAM PEBP family protein
D3868_RS01625	COG0113	porphobilinogen synthase activity
D3868_RS01630	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3868_RS01635	COG1597	lipid kinase activity
D3868_RS01640	COG1024	Enoyl-CoA hydratase
D3868_RS01645	COG1846	Transcriptional regulator
D3868_RS01665	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3868_RS01680	COG0686	Belongs to the AlaDH PNT family
D3868_RS01690	COG0737	Belongs to the 5'-nucleotidase family
D3868_RS01695	COG0512	Glutamine amidotransferase of anthranilate synthase
D3868_RS01700	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D3868_RS01705	COG3608	succinylglutamate desuccinylase aspartoacylase
D3868_RS01705	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D3868_RS01740	COG2358	TRAP transporter, solute receptor (TAXI family
D3868_RS01770	COG0123	including yeast histone deacetylase and acetoin utilization protein
D3868_RS01815	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D3868_RS01820	COG0626	cystathionine gamma-synthase activity
D3868_RS01825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_RS01830	COG4597	amino acid ABC transporter
D3868_RS01835	COG0765	amino acid transport
D3868_RS01840	COG1126	abc transporter atp-binding protein
D3868_RS01845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3868_RS01865	COG2897	thiosulfate sulfurtransferase activity
D3868_RS01880	COG0494	nUDIX hydrolase
D3868_RS01885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3868_RS01910	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3868_RS01920	COG1538	Outer membrane efflux protein
D3868_RS01930	COG0525	valine-tRNA ligase activity
D3868_RS01935	COG0840	transmembrane signaling receptor activity
D3868_RS01950	COG1686	Belongs to the peptidase S11 family
D3868_RS01955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D3868_RS01960	COG0470	DNA polymerase III
D3868_RS01970	COG0084	hydrolase, TatD family'
D3868_RS01975	COG0321	lipoyl(octanoyl) transferase activity
D3868_RS01975	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D3868_RS01990	COG0631	protein serine/threonine phosphatase activity
D3868_RS02000	COG2957	Belongs to the agmatine deiminase family
D3868_RS02005	COG1177	transmembrane transport
D3868_RS02010	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_RS02015	COG3842	ATPase activity
D3868_RS02025	COG0174	glutamine synthetase
D3868_RS02030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3868_RS02060	COG0861	Integral membrane protein TerC family
D3868_RS02070	COG4957	zinc ion binding
D3868_RS02105	COG1280	lysine exporter protein (LysE YggA)
D3868_RS02115	COG0314	molybdopterin synthase activity
D3868_RS02120	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D3868_RS02130	COG1763	Mo-molybdopterin cofactor biosynthetic process
D3868_RS02135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3868_RS02145	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS02195	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D3868_RS02195	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D3868_RS02200	COG1160	GTP binding
D3868_RS02230	COG2197	response regulator
D3868_RS02300	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D3868_RS02305	COG2814	Major facilitator Superfamily
D3868_RS02320	COG0789	Transcriptional regulator
D3868_RS02325	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_RS02355	COG1116	anion transmembrane transporter activity
D3868_RS02355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3868_RS02365	COG0175	sulfate reduction
D3868_RS02370	COG0175	sulfate reduction
D3868_RS02375	COG1648	precorrin-2 dehydrogenase activity
D3868_RS02375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3868_RS02390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3868_RS02405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3868_RS02405	COG4651	solute:proton antiporter activity
D3868_RS02430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3868_RS02435	COG0416	fatty acid biosynthetic process
D3868_RS02440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D3868_RS02460	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D3868_RS02470	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D3868_RS02475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3868_RS02480	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D3868_RS02485	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3868_RS02485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3868_RS02495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3868_RS02495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3868_RS02500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D3868_RS02505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3868_RS02510	COG0698	ribose 5-phosphate isomerase
D3868_RS02530	COG3685	Protein conserved in bacteria
D3868_RS02550	COG2153	protein acetylation
D3868_RS02560	COG1793	dna ligase
D3868_RS02570	COG2313	pseudouridylate synthase activity
D3868_RS02580	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D3868_RS02600	COG1217	gtp-binding protein TYPA
D3868_RS02635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_RS02655	COG1755	Isoprenylcysteine carboxyl methyltransferase
D3868_RS02660	COG3424	synthase
D3868_RS02680	COG3328	transposase activity
D3868_RS02685	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D3868_RS02690	COG1492	cobalamin metabolic process
D3868_RS02750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D3868_RS02760	COG1024	Enoyl-CoA hydratase
D3868_RS02770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3868_RS02775	COG3411	Ferredoxin
D3868_RS02795	COG3546	catalase activity
D3868_RS02800	COG2211	Major facilitator Superfamily
D3868_RS02805	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D3868_RS02850	COG0546	phosphoglycolate phosphatase activity
D3868_RS02865	COG3108	Peptidase M15
D3868_RS02875	COG1773	rubredoxin
D3868_RS02890	COG1752	Esterase of the alpha-beta hydrolase superfamily
D3868_RS02895	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D3868_RS02945	COG2824	Alkylphosphonate utilization operon protein PhnA
D3868_RS02960	COG0243	molybdopterin cofactor binding
D3868_RS02965	COG2070	2-Nitropropane dioxygenase
D3868_RS02970	COG3706	GGDEF domain
D3868_RS02985	COG1410	methionine synthase
D3868_RS02985	COG0646	methionine synthase
D3868_RS03005	COG2853	Lipoprotein
D3868_RS03020	COG0488	(ABC) transporter
D3868_RS03025	COG1671	Belongs to the UPF0178 family
D3868_RS03030	COG5002	protein histidine kinase activity
D3868_RS03030	COG2176	DNA-directed DNA polymerase activity
D3868_RS03055	COG1640	4-alpha-glucanotransferase
D3868_RS03060	COG0745	RESPONSE REGULATOR receiver
D3868_RS03070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3868_RS03075	COG0366	Alpha amylase catalytic
D3868_RS03090	COG1218	3'(2'),5'-bisphosphate nucleotidase
D3868_RS03095	COG2833	Protein of unknown function (DUF455)
D3868_RS03110	COG1960	acyl-CoA dehydrogenase activity
D3868_RS03115	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS03120	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_RS03125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_RS03130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3868_RS03170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_RS03180	COG1846	Transcriptional regulator
D3868_RS03185	COG2267	carboxylic ester hydrolase activity
D3868_RS03200	COG2226	methyltransferase
D3868_RS03220	COG1201	RNA secondary structure unwinding
D3868_RS03230	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D3868_RS03235	COG0415	Belongs to the DNA photolyase family
D3868_RS03245	COG0735	belongs to the Fur family
D3868_RS03250	COG0523	cobalamin synthesis protein
D3868_RS03260	COG0463	Glycosyl transferase, family 2
D3868_RS03265	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D3868_RS03270	COG1234	tRNA 3'-trailer cleavage
D3868_RS03285	COG0840	transmembrane signaling receptor activity
D3868_RS03300	COG4520	surface antigen
D3868_RS03305	COG0484	heat shock protein binding
D3868_RS03330	COG4191	Histidine kinase
D3868_RS03330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_RS03345	COG3437	response regulator, receiver
D3868_RS03345	COG0784	Response regulator, receiver
D3868_RS03365	COG2076	Multidrug Resistance protein
D3868_RS03370	COG0300	oxidoreductase activity
D3868_RS03375	COG1765	OsmC-like protein
D3868_RS03385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D3868_RS03395	COG0697	spore germination
D3868_RS03400	COG0367	asparagine synthase
D3868_RS03415	COG0438	transferase activity, transferring glycosyl groups
D3868_RS03420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3868_RS03440	COG2885	chlorophyll binding
D3868_RS03455	COG0848	biopolymer transport protein
D3868_RS03465	COG0824	Thioesterase
D3868_RS03470	COG2255	four-way junction helicase activity
D3868_RS03485	COG0217	transcriptional regulatory protein
D3868_RS03490	COG1692	metallophosphoesterase
D3868_RS03495	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D3868_RS03540	COG1830	Aldolase
D3868_RS03545	COG0352	thiamine-phosphate diphosphorylase activity
D3868_RS03550	COG0730	response to heat
D3868_RS03555	COG2067	long-chain fatty acid transport protein
D3868_RS03560	COG0604	alcohol dehydrogenase
D3868_RS03565	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D3868_RS03570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D3868_RS03575	COG0483	inositol monophosphate 1-phosphatase activity
D3868_RS03595	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D3868_RS03605	COG0509	glycine decarboxylation via glycine cleavage system
D3868_RS03610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D3868_RS03625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D3868_RS03630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D3868_RS03640	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_RS03645	COG0678	peroxiredoxin activity
D3868_RS03650	COG4232	protein-disulfide reductase activity
D3868_RS03655	COG1678	Uncharacterized ACR, COG1678
D3868_RS03665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3868_RS03670	COG0612	Peptidase, M16
D3868_RS03685	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D3868_RS03690	COG3346	SURF1 family
D3868_RS03710	COG0109	protoheme IX farnesyltransferase activity
D3868_RS03715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3868_RS03720	COG1565	acr, cog1565
D3868_RS03720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3868_RS03730	COG0312	modulator of DNA gyrase
D3868_RS03735	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D3868_RS03740	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3868_RS03750	COG5487	UPF0391 membrane protein
D3868_RS03760	COG0741	lytic transglycosylase activity
D3868_RS03790	COG0564	pseudouridine synthase activity
D3868_RS03805	COG3266	domain, Protein
D3868_RS03805	COG0515	serine threonine protein kinase
D3868_RS03810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D3868_RS03815	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D3868_RS03825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3868_RS03840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D3868_RS03845	COG1295	ribonuclease BN
D3868_RS03850	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3868_RS03860	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D3868_RS03870	COG0745	RESPONSE REGULATOR receiver
D3868_RS03880	COG0616	signal peptide processing
D3868_RS03895	COG0784	Response regulator, receiver
D3868_RS03895	COG2198	Histidine kinase
D3868_RS03895	COG5002	protein histidine kinase activity
D3868_RS03905	COG0390	transport system, permease component
D3868_RS03910	COG1136	(ABC) transporter
D3868_RS03910	COG0577	efflux transmembrane transporter activity
D3868_RS03920	COG0628	permease
D3868_RS03925	COG2205	protein histidine kinase activity
D3868_RS03935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3868_RS03945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3868_RS03950	COG0251	oxidation-reduction process
D3868_RS03960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3868_RS03960	COG0551	DNA topoisomerase type I activity
D3868_RS03990	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3868_RS04000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3868_RS04015	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D3868_RS04015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3868_RS04025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3868_RS04040	COG0505	Belongs to the CarA family
D3868_RS04050	COG1403	HNH endonuclease
D3868_RS04060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3868_RS04065	COG1393	Belongs to the ArsC family
D3868_RS04070	COG2890	protein-(glutamine-N5) methyltransferase activity
D3868_RS04075	COG0456	acetyltransferase
D3868_RS04075	COG1214	PFAM Peptidase M22, glycoprotease
D3868_RS04115	COG0538	isocitrate dehydrogenase activity
D3868_RS04125	COG3932	Exopolysaccharide synthesis, ExoD
D3868_RS04145	COG0473	3-isopropylmalate dehydrogenase activity
D3868_RS04175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3868_RS04195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3868_RS04210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D3868_RS04230	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3868_RS04235	COG1684	flagellar biosynthetic protein fliR
D3868_RS04240	COG1987	bacterial-type flagellum assembly
D3868_RS04245	COG1677	Flagellar hook-basal body complex protein FliE
D3868_RS04250	COG1558	bacterial-type flagellum-dependent cell motility
D3868_RS04255	COG1815	bacterial-type flagellum-dependent cell motility
D3868_RS04260	COG2257	FlhB HrpN YscU SpaS Family
D3868_RS04275	COG1338	Plays a role in the flagellum-specific transport system
D3868_RS04290	COG1360	Flagellar Motor Protein
D3868_RS04330	COG4786	Flagellar basal body rod
D3868_RS04335	COG4786	Flagellar basal body rod
D3868_RS04345	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D3868_RS04385	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D3868_RS04410	COG0500	methyltransferase
D3868_RS04420	COG1132	(ABC) transporter
D3868_RS04425	COG0254	rRNA binding
D3868_RS04435	COG0071	Belongs to the small heat shock protein (HSP20) family
D3868_RS04455	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D3868_RS04470	COG2186	Transcriptional regulator
D3868_RS04475	COG0563	adenylate kinase activity
D3868_RS04480	COG0201	protein transport
D3868_RS04485	COG0200	Binds to the 23S rRNA
D3868_RS04490	COG1841	ribosomal large subunit assembly
D3868_RS04505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D3868_RS04510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D3868_RS04515	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D3868_RS04525	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D3868_RS04535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D3868_RS04540	COG0255	Belongs to the universal ribosomal protein uL29 family
D3868_RS04545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D3868_RS04550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D3868_RS04555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D3868_RS04560	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D3868_RS04565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D3868_RS04570	COG0089	rRNA binding
D3868_RS04575	COG0088	Forms part of the polypeptide exit tunnel
D3868_RS04585	COG0051	transcription antitermination factor activity, RNA binding
D3868_RS04590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3868_RS04600	COG0049	tRNA binding
D3868_RS04615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D3868_RS04620	COG0085	RNA polymerase activity
D3868_RS04625	COG0222	ribosome binding
D3868_RS04630	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D3868_RS04635	COG0081	regulation of translation
D3868_RS04640	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D3868_RS04660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3868_RS04750	COG1940	carbohydrate kinase activity
D3868_RS04765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3868_RS04775	COG0411	ABC transporter
D3868_RS04810	COG0673	inositol 2-dehydrogenase activity
D3868_RS04820	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3868_RS04830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_RS04835	COG1309	transcriptional regulator
D3868_RS04845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3868_RS04865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3868_RS04910	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3868_RS04915	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3868_RS04920	COG1530	ribonuclease E activity
D3868_RS04950	COG0436	Aminotransferase
D3868_RS04960	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D3868_RS04975	COG2264	protein methyltransferase activity
D3868_RS04985	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D3868_RS05000	COG0312	modulator of DNA gyrase
D3868_RS05010	COG1597	lipid kinase activity
D3868_RS05020	COG0438	transferase activity, transferring glycosyl groups
D3868_RS05030	COG1519	Transferase
D3868_RS05035	COG1663	tetraacyldisaccharide 4'-kinase activity
D3868_RS05070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3868_RS05080	COG0590	tRNA wobble adenosine to inosine editing
D3868_RS05105	COG2703	oxygen carrier activity
D3868_RS05110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3868_RS05140	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D3868_RS05150	COG2030	dehydratase
D3868_RS05155	COG0196	riboflavin kinase activity
D3868_RS05160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3868_RS05165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D3868_RS05170	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D3868_RS05180	COG0612	Peptidase, M16
D3868_RS05185	COG0612	Peptidase, M16
D3868_RS05195	COG0166	Belongs to the GPI family
D3868_RS05235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3868_RS05250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3868_RS05275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3868_RS05280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3868_RS05305	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3868_RS05310	COG2188	Transcriptional regulator
D3868_RS05315	COG0667	Aldo Keto reductase
D3868_RS05340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3868_RS05345	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS05380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D3868_RS05390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3868_RS05395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3868_RS05425	COG1309	transcriptional regulator
D3868_RS05435	COG1518	maintenance of DNA repeat elements
D3868_RS05475	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3868_RS05490	COG0742	ribosomal rna small subunit methyltransferase
D3868_RS05495	COG1187	pseudouridine synthase activity
D3868_RS05500	COG3360	Dodecin
D3868_RS05505	COG0590	tRNA wobble adenosine to inosine editing
D3868_RS05520	COG1570	exodeoxyribonuclease VII activity
D3868_RS05530	COG0418	dihydroorotase activity
D3868_RS05535	COG0124	histidyl-tRNA synthetase
D3868_RS05575	COG1546	Belongs to the CinA family
D3868_RS05575	COG1058	Belongs to the CinA family
D3868_RS05580	COG1489	DNA binding
D3868_RS05605	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D3868_RS05620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3868_RS05625	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3868_RS05635	COG2258	MOSC domain
D3868_RS05645	COG0583	DNA-binding transcription factor activity
D3868_RS05650	COG0047	phosphoribosylformylglycinamidine synthase activity
D3868_RS05655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3868_RS05665	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D3868_RS05675	COG2962	Rard protein
D3868_RS05685	COG1902	pentaerythritol trinitrate reductase activity
D3868_RS05690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D3868_RS05705	COG3279	Response regulator of the LytR AlgR family
D3868_RS05715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3868_RS05725	COG2205	protein histidine kinase activity
D3868_RS05770	COG0723	plastoquinol--plastocyanin reductase activity
D3868_RS05785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3868_RS05795	COG0463	Glycosyl transferase, family 2
D3868_RS05820	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D3868_RS05860	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D3868_RS05870	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D3868_RS05880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3868_RS05900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3868_RS05900	COG2010	Cytochrome c
D3868_RS05915	COG0799	negative regulation of ribosome biogenesis
D3868_RS05920	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D3868_RS05925	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D3868_RS05935	COG0793	Belongs to the peptidase S41A family
D3868_RS05945	COG1051	belongs to the nudix hydrolase family
D3868_RS05965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D3868_RS05975	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3868_RS05995	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3868_RS06005	COG4974	Belongs to the 'phage' integrase family
D3868_RS06010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3868_RS06020	COG0596	Alpha beta hydrolase
D3868_RS06040	COG4191	Histidine kinase
D3868_RS06045	COG4106	trans-aconitate 2-methyltransferase activity
D3868_RS06065	COG2226	methyltransferase
D3868_RS06070	COG0126	phosphoglycerate kinase activity
D3868_RS06080	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D3868_RS06095	COG3474	cytochrome
D3868_RS06100	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D3868_RS06130	COG4166	transmembrane transport
D3868_RS06140	COG4166	transmembrane transport
D3868_RS06145	COG4174	ABC transporter (Permease)
D3868_RS06155	COG4239	(ABC) transporter, permease
D3868_RS06160	COG4172	Belongs to the ABC transporter superfamily
D3868_RS06195	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3868_RS06200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3868_RS06210	COG2358	TRAP transporter, solute receptor (TAXI family
D3868_RS06265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3868_RS06270	COG0625	glutathione transferase activity
D3868_RS06280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3868_RS06285	COG0601	transmembrane transport
D3868_RS06310	COG0583	DNA-binding transcription factor activity
D3868_RS06335	COG5001	Diguanylate cyclase
D3868_RS06340	COG0625	glutathione transferase activity
D3868_RS06345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3868_RS06355	COG0156	8-amino-7-oxononanoate synthase activity
D3868_RS06370	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS06385	COG1322	Protein conserved in bacteria
D3868_RS06390	COG1278	Cold shock
D3868_RS06400	COG0242	peptide deformylase activity
D3868_RS06405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D3868_RS06410	COG0101	tRNA pseudouridine synthase activity
D3868_RS06430	COG2378	regulation of single-species biofilm formation
D3868_RS06435	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3868_RS06450	COG0335	large ribosomal subunit rRNA binding
D3868_RS06460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D3868_RS06465	COG0228	four-way junction DNA binding
D3868_RS06470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D3868_RS06525	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D3868_RS06540	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3868_RS06550	COG1131	(ABC) transporter
D3868_RS06560	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D3868_RS06575	COG0489	protein tyrosine kinase activity
D3868_RS06575	COG3206	protein involved in exopolysaccharide biosynthesis
D3868_RS06585	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D3868_RS06595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3868_RS06610	COG0438	transferase activity, transferring glycosyl groups
D3868_RS06640	COG1215	transferase activity, transferring glycosyl groups
D3868_RS06650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D3868_RS06660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D3868_RS06665	COG0706	membrane insertase activity
D3868_RS06670	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D3868_RS06685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3868_RS06695	COG0598	Magnesium transport protein CorA
D3868_RS06710	COG0825	malonyl-CoA metabolic process
D3868_RS06720	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D3868_RS06735	COG4974	Belongs to the 'phage' integrase family
D3868_RS06755	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D3868_RS06760	COG0517	IMP dehydrogenase activity
D3868_RS06775	COG0271	Belongs to the BolA IbaG family
D3868_RS06805	COG1840	ABC-type Fe3 transport system, periplasmic component
D3868_RS06810	COG1741	Belongs to the pirin family
D3868_RS06820	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3868_RS06830	COG0135	phosphoribosylanthranilate isomerase activity
D3868_RS06850	COG2423	ornithine cyclodeaminase activity
D3868_RS06860	COG0776	regulation of translation
D3868_RS06870	COG0539	negative regulation of cytoplasmic translation
D3868_RS06885	COG0405	Gamma-glutamyltransferase
D3868_RS06905	COG1741	Belongs to the pirin family
D3868_RS06925	COG2205	protein histidine kinase activity
D3868_RS06925	COG5002	protein histidine kinase activity
D3868_RS06925	COG0784	Response regulator, receiver
D3868_RS06935	COG0463	Glycosyl transferase, family 2
D3868_RS06945	COG0071	Belongs to the small heat shock protein (HSP20) family
D3868_RS06985	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D3868_RS07010	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D3868_RS07035	COG3162	membrane
D3868_RS07055	COG1971	Probably functions as a manganese efflux pump
D3868_RS07060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3868_RS07065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D3868_RS07070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3868_RS07075	COG1987	bacterial-type flagellum assembly
D3868_RS07080	COG4106	trans-aconitate 2-methyltransferase activity
D3868_RS07100	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D3868_RS07105	COG0513	Belongs to the DEAD box helicase family
D3868_RS07110	COG1970	mechanosensitive ion channel activity
D3868_RS07115	COG0653	protein targeting
D3868_RS07120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3868_RS07125	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D3868_RS07135	COG0494	nUDIX hydrolase
D3868_RS07140	COG0514	ATP-dependent DNA helicase (RecQ)
D3868_RS07170	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3868_RS07175	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_RS07205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3868_RS07215	COG0412	Dienelactone hydrolase
D3868_RS07220	COG0033	Phosphoglucomutase
D3868_RS07225	COG1278	Cold shock
D3868_RS07265	COG0444	Belongs to the ABC transporter superfamily
D3868_RS07270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3868_RS07275	COG0601	transmembrane transport
D3868_RS07285	COG0747	negative chemotaxis
D3868_RS07345	COG0671	phosphoesterase, PA-phosphatase related
D3868_RS07355	COG0784	Response regulator, receiver
D3868_RS07355	COG3437	response regulator, receiver
D3868_RS07370	COG1983	PspC domain protein
D3868_RS07380	COG1842	Phage shock protein A
D3868_RS07385	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D3868_RS07395	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3868_RS07410	COG3005	denitrification pathway
D3868_RS07415	COG1858	cytochrome C peroxidase
D3868_RS07420	COG0753	catalase activity
D3868_RS07425	COG0459	protein refolding
D3868_RS07430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D3868_RS07435	COG5425	PFAM Usg family protein
D3868_RS07440	COG3772	lysozyme
D3868_RS07445	COG0493	'glutamate synthase
D3868_RS07445	COG0543	2 iron, 2 sulfur cluster binding
D3868_RS07450	COG1612	heme a metabolic process
D3868_RS07480	COG0668	transmembrane transport
D3868_RS07485	COG0784	Response regulator, receiver
D3868_RS07485	COG3437	response regulator, receiver
D3868_RS07490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3868_RS07505	COG3800	Transcriptional regulator
D3868_RS07505	COG1396	sequence-specific DNA binding
D3868_RS07510	COG2224	Isocitrate lyase
D3868_RS07515	COG0693	protein deglycase activity
D3868_RS07520	COG2202	Pas domain
D3868_RS07520	COG2205	protein histidine kinase activity
D3868_RS07525	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D3868_RS07530	COG0674	pyruvate-flavodoxin oxidoreductase activity
D3868_RS07530	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D3868_RS07535	COG1013	pyruvate-flavodoxin oxidoreductase activity
D3868_RS07555	COG3685	Protein conserved in bacteria
D3868_RS07575	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D3868_RS07580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3868_RS07590	COG0747	negative chemotaxis
D3868_RS07670	COG3436	PFAM IS66 Orf2 family protein
D3868_RS07675	COG3328	transposase activity
D3868_RS07705	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D3868_RS07720	COG3415	Transposase
D3868_RS07735	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3868_RS07875	COG0464	growth
D3868_RS07885	COG3485	protocatechuate 3,4-dioxygenase
D3868_RS07920	COG2264	protein methyltransferase activity
D3868_RS07995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3868_RS08000	COG0347	Belongs to the P(II) protein family
D3868_RS08005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3868_RS08010	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D3868_RS08030	COG4181	ATPase activity
D3868_RS08040	COG3706	GGDEF domain
D3868_RS08050	COG0443	Heat shock 70 kDa protein
D3868_RS08085	COG1420	regulation of RNA biosynthetic process
D3868_RS08090	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D3868_RS08095	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D3868_RS08100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3868_RS08110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D3868_RS08140	COG0792	nuclease activity
D3868_RS08145	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D3868_RS08165	COG1366	Belongs to the anti-sigma-factor antagonist family
D3868_RS08175	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D3868_RS08215	COG2205	protein histidine kinase activity
D3868_RS08215	COG0784	Response regulator, receiver
D3868_RS08225	COG0180	Tryptophanyl-tRNA synthetase
D3868_RS08230	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D3868_RS08240	COG3012	SEC-C Motif Domain Protein
D3868_RS08255	COG0110	maltose O-acetyltransferase activity
D3868_RS08260	COG1309	transcriptional regulator
D3868_RS08265	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS08280	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D3868_RS08285	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D3868_RS08290	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3868_RS08315	COG0438	transferase activity, transferring glycosyl groups
D3868_RS08320	COG3706	GGDEF domain
D3868_RS08335	COG1132	(ABC) transporter
D3868_RS08340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3868_RS08340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_RS08370	COG0747	negative chemotaxis
D3868_RS08375	COG0601	transmembrane transport
D3868_RS08380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3868_RS08390	COG1234	tRNA 3'-trailer cleavage
D3868_RS08410	COG0745	RESPONSE REGULATOR receiver
D3868_RS08485	COG0357	Ribosomal RNA small subunit methyltransferase G
D3868_RS08490	COG0445	tRNA wobble uridine modification
D3868_RS08500	COG3411	Ferredoxin
D3868_RS08515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3868_RS08525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3868_RS08530	COG0237	dephospho-CoA kinase activity
D3868_RS08555	COG1981	membrane
D3868_RS08575	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D3868_RS08580	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D3868_RS08590	COG4395	Tim44
D3868_RS08595	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D3868_RS08650	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D3868_RS08655	COG0488	(ABC) transporter
D3868_RS08660	COG2205	protein histidine kinase activity
D3868_RS08675	COG1556	Lactate utilization protein
D3868_RS08680	COG1139	Iron-sulfur cluster binding protein
D3868_RS08685	COG0247	lactate metabolic process
D3868_RS08705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3868_RS08710	COG1121	(ABC) transporter
D3868_RS08720	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D3868_RS08725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3868_RS08735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3868_RS08750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3868_RS08755	COG0730	response to heat
D3868_RS08780	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D3868_RS08790	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D3868_RS08795	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D3868_RS08825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3868_RS08830	COG1702	phosphate starvation-inducible protein PhoH
D3868_RS08840	COG1253	flavin adenine dinucleotide binding
D3868_RS08845	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D3868_RS08850	COG1396	sequence-specific DNA binding
D3868_RS08855	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D3868_RS08870	COG0779	Required for maturation of 30S ribosomal subunits
D3868_RS08895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D3868_RS08905	COG1185	polyribonucleotide nucleotidyltransferase activity
D3868_RS08915	COG2321	neutral zinc metallopeptidase
D3868_RS08925	COG1509	lysine 2,3-aminomutase activity
D3868_RS08930	COG0584	glycerophosphoryl diester phosphodiesterase
D3868_RS08945	COG1592	Rubrerythrin
D3868_RS08975	COG0039	L-malate dehydrogenase activity
D3868_RS08980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D3868_RS08985	COG4166	transmembrane transport
D3868_RS08995	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3868_RS09000	COG2226	methyltransferase
D3868_RS09005	COG0457	Tetratricopeptide repeat
D3868_RS09005	COG0859	PFAM glycosyl transferase family 9
D3868_RS09015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D3868_RS09025	COG1024	Enoyl-CoA hydratase
D3868_RS09030	COG0268	Binds directly to 16S ribosomal RNA
D3868_RS09035	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D3868_RS09040	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3868_RS09045	COG3842	ATPase activity
D3868_RS09065	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_RS09070	COG1177	transmembrane transport
D3868_RS09085	COG2132	Multicopper oxidase
D3868_RS09135	COG2217	Heavy metal translocating P-type atpase
D3868_RS09145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_RS09150	COG0280	phosphate acetyltransferase
D3868_RS09150	COG0281	malic enzyme
D3868_RS09160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D3868_RS09165	COG0573	inorganic phosphate transmembrane transporter activity
D3868_RS09175	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D3868_RS09185	COG0745	RESPONSE REGULATOR receiver
D3868_RS09200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D3868_RS09210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3868_RS09220	COG0756	dUTP diphosphatase activity
D3868_RS09225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D3868_RS09230	COG2204	response regulator
D3868_RS09235	COG1278	Cold shock
D3868_RS09240	COG5002	protein histidine kinase activity
D3868_RS09240	COG2205	protein histidine kinase activity
D3868_RS09240	COG0784	Response regulator, receiver
D3868_RS09245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3868_RS09250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3868_RS09250	COG1321	iron dependent repressor
D3868_RS09255	COG1121	(ABC) transporter
D3868_RS09260	COG0803	Belongs to the bacterial solute-binding protein 9 family
D3868_RS09295	COG2202	Pas domain
D3868_RS09295	COG2205	protein histidine kinase activity
D3868_RS09315	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D3868_RS09320	COG1253	flavin adenine dinucleotide binding
D3868_RS09335	COG0477	Major facilitator Superfamily
D3868_RS09340	COG0583	DNA-binding transcription factor activity
D3868_RS09345	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D3868_RS09370	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3868_RS09385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D3868_RS09390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D3868_RS09395	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D3868_RS09410	COG3437	response regulator, receiver
D3868_RS09410	COG0784	Response regulator, receiver
D3868_RS09420	COG0583	DNA-binding transcription factor activity
D3868_RS09435	COG0481	GTPase activity
D3868_RS09445	COG0297	glycogen (starch) synthase activity
D3868_RS09450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3868_RS09455	COG0004	ammonium transporteR
D3868_RS09485	COG1595	DNA-templated transcription, initiation
D3868_RS09495	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D3868_RS09510	COG0137	argininosuccinate synthase activity
D3868_RS09525	COG2897	thiosulfate sulfurtransferase activity
D3868_RS09530	COG3339	Conserved Protein
D3868_RS09535	COG0697	spore germination
D3868_RS09540	COG4235	cytochrome complex assembly
D3868_RS09545	COG3088	subunit of a heme lyase
D3868_RS09550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3868_RS09555	COG1138	Cytochrome C-type biogenesis protein
D3868_RS09560	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D3868_RS09570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3868_RS09575	COG0583	DNA-binding transcription factor activity
D3868_RS09585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3868_RS09590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D3868_RS09595	COG1573	uracil-dna glycosylase
D3868_RS09605	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3868_RS09615	COG0598	Magnesium transport protein CorA
D3868_RS09620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D3868_RS09625	COG1872	DUF167
D3868_RS09670	COG2985	domain, Protein
D3868_RS09675	COG4133	protoheme IX ABC transporter activity
D3868_RS09680	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3868_RS09705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D3868_RS09715	COG0802	atpase or kinase
D3868_RS09745	COG1252	NADH dehydrogenase
D3868_RS09750	COG2205	protein histidine kinase activity
D3868_RS09760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_RS09765	COG0133	tryptophan synthase activity
D3868_RS09775	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D3868_RS09780	COG0285	dihydrofolate synthase activity
D3868_RS09795	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS09810	COG2205	protein histidine kinase activity
D3868_RS09815	COG0302	gtp cyclohydrolase
D3868_RS09825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D3868_RS09835	COG0302	gtp cyclohydrolase
D3868_RS09840	COG2967	ApaG domain
D3868_RS09885	COG0514	ATP-dependent DNA helicase (RecQ)
D3868_RS09950	COG0443	Heat shock 70 kDa protein
D3868_RS09955	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3868_RS10040	COG0582	viral genome integration into host DNA
D3868_RS10060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_RS10075	COG0784	Response regulator, receiver
D3868_RS10075	COG2205	protein histidine kinase activity
D3868_RS10075	COG5002	protein histidine kinase activity
D3868_RS10095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3868_RS10100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_RS10100	COG4191	Histidine kinase
D3868_RS10110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3868_RS10120	COG2885	chlorophyll binding
D3868_RS10150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3868_RS10180	COG0181	hydroxymethylbilane synthase activity
D3868_RS10185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3868_RS10200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D3868_RS10205	COG2350	Protein conserved in bacteria
D3868_RS10220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3868_RS10235	COG5508	conserved small protein
D3868_RS10240	COG0501	Belongs to the peptidase M48B family
D3868_RS10255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3868_RS10255	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D3868_RS10265	COG0138	bifunctional purine biosynthesis protein purh
D3868_RS10290	COG2264	protein methyltransferase activity
D3868_RS10295	COG2902	Dehydrogenase
D3868_RS10300	COG3437	response regulator, receiver
D3868_RS10320	COG0679	Auxin Efflux Carrier
D3868_RS10325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3868_RS10340	COG3118	belongs to the thioredoxin family
D3868_RS10345	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3868_RS10350	COG2835	tetraacyldisaccharide 4'-kinase activity
D3868_RS10385	COG1285	pathogenesis
D3868_RS10390	COG2814	Major facilitator Superfamily
D3868_RS10400	COG0784	Response regulator, receiver
D3868_RS10400	COG2205	protein histidine kinase activity
D3868_RS10420	COG0395	ABC-type sugar transport system, permease component
D3868_RS10430	COG0625	glutathione transferase activity
D3868_RS10450	COG0513	Belongs to the DEAD box helicase family
D3868_RS10480	COG1366	Belongs to the anti-sigma-factor antagonist family
D3868_RS10490	COG0745	RESPONSE REGULATOR receiver
D3868_RS10525	COG1366	Belongs to the anti-sigma-factor antagonist family
D3868_RS10540	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D3868_RS10550	COG0840	transmembrane signaling receptor activity
D3868_RS10555	COG0835	chemotaxis
D3868_RS10560	COG0643	Histidine kinase
D3868_RS10560	COG2198	Histidine kinase
D3868_RS10565	COG0745	RESPONSE REGULATOR receiver
D3868_RS10575	COG5002	protein histidine kinase activity
D3868_RS10585	COG5002	protein histidine kinase activity
D3868_RS10585	COG2176	DNA-directed DNA polymerase activity
D3868_RS10590	COG0745	RESPONSE REGULATOR receiver
D3868_RS10605	COG2917	probably involved in intracellular septation
D3868_RS10615	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D3868_RS10620	COG0552	protein localization to endoplasmic reticulum
D3868_RS10625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3868_RS10630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D3868_RS10680	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D3868_RS10695	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D3868_RS10700	COG3706	GGDEF domain
D3868_RS10705	COG2205	protein histidine kinase activity
D3868_RS10710	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3868_RS10725	COG0045	succinate-CoA ligase (ADP-forming) activity
D3868_RS10730	COG0039	L-malate dehydrogenase activity
D3868_RS10750	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D3868_RS10755	COG2076	Multidrug Resistance protein
D3868_RS10765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3868_RS10770	COG1199	ATP-dependent helicase activity
D3868_RS10770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3868_RS10785	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D3868_RS10795	COG2972	Histidine kinase
D3868_RS10795	COG0840	transmembrane signaling receptor activity
D3868_RS10810	COG2084	Dehydrogenase
D3868_RS10820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3868_RS10855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3868_RS10935	COG0531	amino acid
D3868_RS10955	COG3485	protocatechuate 3,4-dioxygenase
D3868_RS10965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D3868_RS10975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3868_RS11005	COG3621	Patatin-like phospholipase
D3868_RS11015	COG3328	transposase activity
D3868_RS11035	COG1074	ATP-dependent DNA helicase activity
D3868_RS11185	COG0167	dihydroorotate dehydrogenase activity
D3868_RS11195	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D3868_RS11200	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3868_RS11205	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3868_RS11275	COG3119	arylsulfatase activity
D3868_RS11310	COG0714	Associated with various cellular activities
D3868_RS11320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3868_RS11335	COG0583	DNA-binding transcription factor activity
D3868_RS11340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3868_RS11345	COG1024	Enoyl-CoA hydratase
D3868_RS11355	COG0154	amidase activity
D3868_RS11360	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS11380	COG0411	ABC transporter
D3868_RS11410	COG1136	(ABC) transporter
D3868_RS11440	COG2304	oxidoreductase activity
D3868_RS11445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3868_RS11500	COG0783	Belongs to the Dps family
D3868_RS11510	COG0492	ferredoxin-NADP+ reductase activity
D3868_RS11525	COG3660	Nucleoside-diphosphate-sugar epimerase
D3868_RS11530	COG1522	sequence-specific DNA binding
D3868_RS11540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3868_RS11545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D3868_RS11570	COG1674	ftsk spoiiie
D3868_RS11595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3868_RS11605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3868_RS11610	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS11615	COG1238	metal cluster binding
D3868_RS11635	COG1012	belongs to the aldehyde dehydrogenase family
D3868_RS11650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_RS11650	COG2205	protein histidine kinase activity
D3868_RS11660	COG1131	(ABC) transporter
D3868_RS11710	COG1116	anion transmembrane transporter activity
D3868_RS11750	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D3868_RS11765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3868_RS11770	COG2205	protein histidine kinase activity
D3868_RS11770	COG0784	Response regulator, receiver
D3868_RS11780	COG0745	RESPONSE REGULATOR receiver
D3868_RS11785	COG2766	serine protein kinase
D3868_RS11790	COG2718	Belongs to the UPF0229 family
D3868_RS11795	COG2719	SpoVR family
D3868_RS11810	COG1643	Atp-dependent helicase
D3868_RS11815	COG1116	anion transmembrane transporter activity
D3868_RS11835	COG0745	RESPONSE REGULATOR receiver
D3868_RS11860	COG0330	HflC and HflK could
D3868_RS11865	COG0628	permease
D3868_RS11875	COG3180	Ammonia monooxygenase
D3868_RS11880	COG2988	succinylglutamate desuccinylase activity
D3868_RS11920	COG2205	protein histidine kinase activity
D3868_RS11920	COG2202	Pas domain
D3868_RS11940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3868_RS11950	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D3868_RS11980	COG2197	response regulator
D3868_RS11985	COG2197	response regulator
D3868_RS12005	COG2264	protein methyltransferase activity
D3868_RS12015	COG0006	proline dipeptidase activity
D3868_RS12015	COG0006	proline dipeptidase activity
D3868_RS12020	COG0745	RESPONSE REGULATOR receiver
D3868_RS12035	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3868_RS12040	COG0497	DNA recombination
D3868_RS12060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D3868_RS12075	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D3868_RS12080	COG0849	cell division
D3868_RS12085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D3868_RS12090	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3868_RS12095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D3868_RS12100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D3868_RS12110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D3868_RS12125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3868_RS12135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D3868_RS12155	COG2001	Belongs to the MraZ family
D3868_RS12175	COG0488	(ABC) transporter
D3868_RS12180	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D3868_RS12195	COG0277	FAD linked oxidase domain protein
D3868_RS12200	COG2084	Dehydrogenase
D3868_RS12215	COG4191	Histidine kinase
D3868_RS12215	COG0784	Response regulator, receiver
D3868_RS12240	COG0142	geranyltranstransferase activity
D3868_RS12250	COG2890	protein-(glutamine-N5) methyltransferase activity
D3868_RS12270	COG0752	glycyl-tRNA synthetase alpha subunit
D3868_RS12275	COG0751	glycine-tRNA ligase activity
D3868_RS12280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3868_RS12285	COG1346	cytolysis
D3868_RS12290	COG1380	Effector of murein hydrolase LrgA
D3868_RS12295	COG1073	alpha beta
D3868_RS12320	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3868_RS12330	COG2205	protein histidine kinase activity
D3868_RS12360	COG3409	Peptidoglycan-binding domain 1 protein
D3868_RS12360	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3868_RS12365	COG3108	Peptidase M15
D3868_RS12380	COG0840	transmembrane signaling receptor activity
D3868_RS12410	COG0511	ligase activity, forming carbon-carbon bonds
D3868_RS12415	COG0439	Biotin carboxylase
D3868_RS12420	COG3719	Belongs to the RNase T2 family
D3868_RS12445	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D3868_RS12470	COG1686	Belongs to the peptidase S11 family
D3868_RS12485	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3868_RS12490	COG0746	molybdenum cofactor guanylyltransferase activity
D3868_RS12515	COG0243	molybdopterin cofactor binding
D3868_RS12515	COG3383	formate dehydrogenase (NAD+) activity
D3868_RS12520	COG0437	4 iron, 4 sulfur cluster binding
D3868_RS12545	COG0235	Class ii aldolase
D3868_RS12555	COG3384	dioxygenase
D3868_RS12565	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3868_RS12570	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3868_RS12575	COG0356	it plays a direct role in the translocation of protons across the membrane
D3868_RS12585	COG1999	signal sequence binding
D3868_RS12600	COG1702	phosphate starvation-inducible protein PhoH
D3868_RS12605	COG0850	regulation of cytokinetic process
D3868_RS12610	COG2894	cell division
D3868_RS12615	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D3868_RS12640	COG4948	Mandelate Racemase Muconate Lactonizing
D3868_RS12650	COG1104	cysteine desulfurase activity
D3868_RS12660	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3868_RS12675	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D3868_RS12690	COG0840	transmembrane signaling receptor activity
D3868_RS12700	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D3868_RS12705	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3868_RS12710	COG1278	Cold shock
D3868_RS12745	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D3868_RS12800	COG5420	small protein containing a coiled-coil domain
D3868_RS12815	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D3868_RS12820	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D3868_RS12875	COG0121	glutamine amidotransferase
D3868_RS12890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3868_RS12915	COG5554	nitrogen fixation
D3868_RS12930	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3868_RS12955	COG1309	transcriptional regulator
D3868_RS12965	COG1131	(ABC) transporter
D3868_RS12975	COG0842	Transport permease protein
D3868_RS12980	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D3868_RS12990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D3868_RS12995	COG0277	FAD linked oxidase domain protein
D3868_RS13000	COG0277	FAD linked oxidase domain protein
D3868_RS13005	COG0247	lactate metabolic process
D3868_RS13025	COG1960	acyl-CoA dehydrogenase activity
D3868_RS13040	COG0277	FAD linked oxidase domain protein
D3868_RS13045	COG0009	L-threonylcarbamoyladenylate synthase
D3868_RS13050	COG1192	Involved in chromosome partitioning
D3868_RS13060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3868_RS13065	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D3868_RS13080	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D3868_RS13085	COG2945	thiolester hydrolase activity
D3868_RS13090	COG1045	serine acetyltransferase
D3868_RS13105	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D3868_RS13110	COG0633	Ferredoxin
D3868_RS13115	COG0482	sulfurtransferase activity
D3868_RS13130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_RS13155	COG4221	oxidoreductase activity
D3868_RS13165	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D3868_RS13175	COG2205	protein histidine kinase activity
D3868_RS13175	COG0784	Response regulator, receiver
D3868_RS13185	COG0745	RESPONSE REGULATOR receiver
D3868_RS13210	COG0432	Pfam Uncharacterised protein family UPF0047
D3868_RS13220	COG2951	lytic endotransglycosylase activity
D3868_RS13240	COG1454	alcohol dehydrogenase
D3868_RS13270	COG0456	acetyltransferase
D3868_RS13285	COG0114	fumarate hydratase activity
D3868_RS13300	COG5002	protein histidine kinase activity
D3868_RS13300	COG5001	Diguanylate cyclase
D3868_RS13305	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D3868_RS13320	COG0205	6-phosphofructokinase activity
D3868_RS13350	COG0288	reversible hydration of carbon dioxide
D3868_RS13365	COG3321	synthase
D3868_RS13365	COG0604	alcohol dehydrogenase
D3868_RS13365	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS13410	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_RS13440	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D3868_RS13445	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D3868_RS13450	COG0343	queuine tRNA-ribosyltransferase activity
D3868_RS13455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D3868_RS13460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3868_RS13465	COG0840	transmembrane signaling receptor activity
D3868_RS13540	COG2201	protein-glutamate methylesterase activity
D3868_RS13590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D3868_RS13595	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3868_RS13600	COG0242	peptide deformylase activity
D3868_RS13610	COG3070	regulator of competence-specific genes
D3868_RS13625	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D3868_RS13650	COG4120	Belongs to the binding-protein-dependent transport system permease family
D3868_RS13665	COG0489	protein tyrosine kinase activity
D3868_RS13670	COG0330	HflC and HflK could
D3868_RS13675	COG0330	HflC and HflK could
D3868_RS13700	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D3868_RS13705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3868_RS13710	COG0028	Belongs to the TPP enzyme family
D3868_RS13725	COG0704	Plays a role in the regulation of phosphate uptake
D3868_RS13730	COG2862	Uncharacterized protein family, UPF0114
D3868_RS13750	COG0768	penicillin binding
D3868_RS13770	COG1744	ABC transporter substrate-binding protein PnrA-like
D3868_RS13775	COG3845	ABC transporter
D3868_RS13785	COG1079	Belongs to the binding-protein-dependent transport system permease family
D3868_RS13790	COG0295	cytidine deaminase activity
D3868_RS13795	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D3868_RS13800	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D3868_RS13815	COG0697	spore germination
D3868_RS13835	COG0411	ABC transporter
D3868_RS13850	COG0038	chloride channel
D3868_RS13860	COG2326	polyphosphate kinase activity
D3868_RS13865	COG0366	Alpha amylase catalytic
D3868_RS13875	COG2199	diguanylate cyclase activity
D3868_RS13875	COG2200	EAL domain
D3868_RS13875	COG2203	Gaf domain
D3868_RS13885	COG2135	peptidase activity
D3868_RS13895	COG0784	Response regulator, receiver
D3868_RS13900	COG2261	transglycosylase associated protein
D3868_RS13905	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3868_RS13920	COG1733	regulation of RNA biosynthetic process
D3868_RS13930	COG2084	Dehydrogenase
D3868_RS13935	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS13950	COG0546	phosphoglycolate phosphatase activity
D3868_RS13965	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3868_RS13975	COG2832	Protein of unknown function (DUF454)
D3868_RS13980	COG1238	metal cluster binding
D3868_RS13985	COG3852	Histidine kinase
D3868_RS13990	COG0469	pyruvate kinase activity
D3868_RS13995	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D3868_RS14010	COG0203	ribosomal protein L17
D3868_RS14015	COG1238	metal cluster binding
D3868_RS14030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D3868_RS14045	COG0564	pseudouridine synthase activity
D3868_RS14050	COG1802	Transcriptional regulator
D3868_RS14055	COG3135	benzoate transporter
D3868_RS14060	COG0546	phosphoglycolate phosphatase activity
D3868_RS14085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3868_RS14090	COG3845	ABC transporter
D3868_RS14095	COG4603	Belongs to the binding-protein-dependent transport system permease family
D3868_RS14250	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D3868_RS14365	COG3547	Transposase (IS116 IS110 IS902 family)
D3868_RS14405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3868_RS14410	COG1414	Transcriptional regulator
D3868_RS14415	COG2376	Dihydroxyacetone kinase
D3868_RS14435	COG1917	Cupin 2, conserved barrel domain protein
D3868_RS14435	COG4977	sequence-specific DNA binding
D3868_RS14445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_RS14460	COG1063	alcohol dehydrogenase
D3868_RS14465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_RS14475	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_RS14480	COG2721	sulfolactate sulfo-lyase activity
D3868_RS14485	COG0246	Mannitol dehydrogenase
D3868_RS14505	COG2358	TRAP transporter, solute receptor (TAXI family
D3868_RS14510	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D3868_RS14515	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D3868_RS14520	COG0583	DNA-binding transcription factor activity
D3868_RS14525	COG2391	methyltransferase activity
D3868_RS14540	COG3842	ATPase activity
D3868_RS14545	COG4149	molybdate abc transporter
D3868_RS14550	COG1840	ABC-type Fe3 transport system, periplasmic component
D3868_RS14565	COG1686	Belongs to the peptidase S11 family
D3868_RS14610	COG1640	4-alpha-glucanotransferase
D3868_RS14640	COG0625	glutathione transferase activity
D3868_RS14645	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS14650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3868_RS14710	COG2099	Precorrin-6x reductase
D3868_RS14740	COG1797	cobyrinic acid a,c-diamide synthase activity
D3868_RS14745	COG0778	Nitroreductase
D3868_RS14750	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS14755	COG1309	transcriptional regulator
D3868_RS14760	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3868_RS14765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3868_RS14770	COG0737	Belongs to the 5'-nucleotidase family
D3868_RS14795	COG1749	Flagellar hook protein flgE
D3868_RS14820	COG0795	lipopolysaccharide-transporting ATPase activity
D3868_RS14825	COG0840	transmembrane signaling receptor activity
D3868_RS14830	COG1137	ATPase activity
D3868_RS14845	COG1376	ErfK ybiS ycfS ynhG family protein
D3868_RS14865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3868_RS14900	COG2723	6-phospho-beta-galactosidase activity
D3868_RS14915	COG2086	electron transfer activity
D3868_RS14925	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3868_RS14935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3868_RS14950	COG0019	diaminopimelate decarboxylase activity
D3868_RS14970	COG0772	Belongs to the SEDS family
D3868_RS14980	COG0745	RESPONSE REGULATOR receiver
D3868_RS15000	COG1253	flavin adenine dinucleotide binding
D3868_RS15005	COG3932	Exopolysaccharide synthesis, ExoD
D3868_RS15010	COG2205	protein histidine kinase activity
D3868_RS15025	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D3868_RS15045	COG1657	PFAM Prenyltransferase squalene oxidase
D3868_RS15070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3868_RS15075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3868_RS15080	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3868_RS15085	COG2080	2 iron, 2 sulfur cluster binding
D3868_RS15090	COG0583	DNA-binding transcription factor activity
D3868_RS15105	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D3868_RS15115	COG1960	acyl-CoA dehydrogenase activity
D3868_RS15155	COG0438	transferase activity, transferring glycosyl groups
D3868_RS15180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D3868_RS15190	COG0288	reversible hydration of carbon dioxide
D3868_RS15200	COG4948	Mandelate Racemase Muconate Lactonizing
D3868_RS15205	COG0583	DNA-binding transcription factor activity
D3868_RS15210	COG0625	glutathione transferase activity
D3868_RS15275	COG1335	isochorismatase
D3868_RS15280	COG4191	Histidine kinase
D3868_RS15285	COG4566	intracellular signal transduction
D3868_RS15330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D3868_RS15355	COG1132	(ABC) transporter
D3868_RS15370	COG1120	ATPase activity
D3868_RS15375	COG4774	siderophore transport
D3868_RS15385	COG0583	DNA-binding transcription factor activity
D3868_RS15390	COG2814	Major facilitator Superfamily
D3868_RS15420	COG0657	acetylesterase activity
D3868_RS15425	COG2423	ornithine cyclodeaminase activity
D3868_RS15430	COG0840	transmembrane signaling receptor activity
D3868_RS15465	COG0765	amino acid transport
D3868_RS15470	COG0765	amino acid transport
D3868_RS15495	COG2879	small protein
D3868_RS15500	COG1966	Carbon starvation protein
D3868_RS15530	COG1609	Transcriptional regulator
D3868_RS15535	COG4221	oxidoreductase activity
D3868_RS15550	COG1024	Enoyl-CoA hydratase
D3868_RS15570	COG1175	transmembrane transport
D3868_RS15580	COG3842	ATPase activity
D3868_RS15605	COG0683	leucine binding
D3868_RS15640	COG4615	Cyclic peptide transporter
D3868_RS15680	COG1320	monovalent cation:proton antiporter activity
D3868_RS15685	COG2212	antiporter activity
D3868_RS15690	COG1863	multisubunit Na H antiporter MnhE subunit
D3868_RS15695	COG0651	ATP synthesis coupled electron transport
D3868_RS15700	COG1006	Multisubunit Na H antiporter MnhC subunit
D3868_RS15705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3868_RS15705	COG2111	Na H antiporter
D3868_RS15715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3868_RS15720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3868_RS15725	COG2091	lysine biosynthetic process via aminoadipic acid
D3868_RS15735	COG2027	D-alanyl-D-alanine carboxypeptidase
D3868_RS15765	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D3868_RS15775	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D3868_RS15785	COG0840	transmembrane signaling receptor activity
D3868_RS15800	COG0745	RESPONSE REGULATOR receiver
D3868_RS15805	COG2205	protein histidine kinase activity
D3868_RS15810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3868_RS15815	COG2864	formate dehydrogenase
D3868_RS15820	COG0437	4 iron, 4 sulfur cluster binding
D3868_RS15825	COG0243	molybdopterin cofactor binding
D3868_RS15825	COG3383	formate dehydrogenase (NAD+) activity
D3868_RS15845	COG0235	Class ii aldolase
D3868_RS15850	COG1942	4-Oxalocrotonate Tautomerase
D3868_RS15890	COG0420	3'-5' exonuclease activity
D3868_RS15900	COG3591	Belongs to the peptidase S1B family
D3868_RS15910	COG1192	Involved in chromosome partitioning
D3868_RS15915	COG1475	DNA binding
D3868_RS15930	COG0583	DNA-binding transcription factor activity
D3868_RS15935	COG0251	oxidation-reduction process
D3868_RS15950	COG3707	response regulator
D3868_RS15955	COG1116	anion transmembrane transporter activity
D3868_RS15965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3868_RS15970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3868_RS15975	COG2146	nitrite reductase [NAD(P)H] activity
D3868_RS15985	COG1648	precorrin-2 dehydrogenase activity
D3868_RS15985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3868_RS15990	COG0791	NLP P60 protein
D3868_RS16000	COG1032	radical SAM domain protein
D3868_RS16050	COG1609	Transcriptional regulator
D3868_RS16055	COG0583	DNA-binding transcription factor activity
D3868_RS16070	COG3195	allantoin biosynthetic process
D3868_RS16070	COG3648	Uricase
D3868_RS16080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3868_RS16100	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D3868_RS16140	COG0243	molybdopterin cofactor binding
D3868_RS16140	COG3383	formate dehydrogenase (NAD+) activity
D3868_RS16145	COG0437	4 iron, 4 sulfur cluster binding
D3868_RS16150	COG2864	formate dehydrogenase
D3868_RS16155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3868_RS16180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_RS16190	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS16275	COG2223	nitrite transmembrane transporter activity
D3868_RS16310	COG1137	ATPase activity
D3868_RS16315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D3868_RS16320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D3868_RS16325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3868_RS16330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3868_RS16335	COG0527	aspartate kinase activity
D3868_RS16340	COG2070	2-Nitropropane dioxygenase
D3868_RS16355	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D3868_RS16360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D3868_RS16370	COG2852	Protein conserved in bacteria
D3868_RS16375	COG2890	protein-(glutamine-N5) methyltransferase activity
D3868_RS16395	COG0542	response to heat
D3868_RS16400	COG1272	protein, Hemolysin III
D3868_RS16405	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D3868_RS16420	COG0840	transmembrane signaling receptor activity
D3868_RS16425	COG5265	(ABC) transporter
D3868_RS16435	COG1703	isobutyryl-CoA mutase activity
D3868_RS16445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D3868_RS16455	COG2137	regulation of response to DNA damage stimulus
D3868_RS16460	COG0842	Transport permease protein
D3868_RS16465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3868_RS16470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D3868_RS16485	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D3868_RS16490	COG0671	phosphoesterase, PA-phosphatase related
D3868_RS16505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D3868_RS16510	COG4774	siderophore transport
D3868_RS16515	COG3128	pkhd-type hydroxylase
D3868_RS16530	COG4604	ABC transporter, ATP-binding protein
D3868_RS16535	COG4605	iron ion homeostasis
D3868_RS16540	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3868_RS16545	COG4607	ABC-type enterochelin transport system periplasmic component
D3868_RS16550	COG1695	Transcriptional regulator
D3868_RS16565	COG0784	Response regulator, receiver
D3868_RS16565	COG2205	protein histidine kinase activity
D3868_RS16565	COG5002	protein histidine kinase activity
D3868_RS16625	COG4206	TonB-dependent receptor
D3868_RS16670	COG3685	Protein conserved in bacteria
D3868_RS16705	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3868_RS16715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3868_RS16720	COG1959	2 iron, 2 sulfur cluster binding
D3868_RS16730	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D3868_RS16740	COG4208	sulfate ABC transporter
D3868_RS16790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D3868_RS16795	COG0367	asparagine synthase
D3868_RS16800	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_RS16820	COG0438	transferase activity, transferring glycosyl groups
D3868_RS16825	COG0438	transferase activity, transferring glycosyl groups
D3868_RS16830	COG1215	transferase activity, transferring glycosyl groups
D3868_RS16850	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D3868_RS16860	COG3693	PFAM glycoside hydrolase, family 10
D3868_RS16870	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D3868_RS16880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D3868_RS16885	COG0588	phosphoglycerate mutase activity
D3868_RS16925	COG2011	ABC-type metal ion transport system permease component
D3868_RS16930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D3868_RS16935	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_RS16940	COG1464	Belongs to the NlpA lipoprotein family
D3868_RS16960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D3868_RS16970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3868_RS16985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D3868_RS16995	COG1530	ribonuclease E activity
D3868_RS17000	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D3868_RS17030	COG1192	Involved in chromosome partitioning
D3868_RS17035	COG1522	sequence-specific DNA binding
D3868_RS17045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3868_RS17060	COG1309	transcriptional regulator
D3868_RS17075	COG5507	3-demethylubiquinone-9 3-methyltransferase
D3868_RS17085	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3868_RS17090	COG1012	belongs to the aldehyde dehydrogenase family
D3868_RS17095	COG1396	sequence-specific DNA binding
D3868_RS17095	COG1917	Cupin 2, conserved barrel domain protein
D3868_RS17105	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_RS17110	COG2182	Extracellular solute-binding protein
D3868_RS17115	COG3842	ATPase activity
D3868_RS17120	COG0583	DNA-binding transcription factor activity
D3868_RS17130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3868_RS17160	COG0471	metal ion transport
D3868_RS17160	COG3273	potassium ion transport
D3868_RS17170	COG2814	Major facilitator Superfamily
D3868_RS17175	COG0583	DNA-binding transcription factor activity
D3868_RS17185	COG1566	PFAM secretion protein HlyD family protein
D3868_RS17225	COG4520	surface antigen
D3868_RS17230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3868_RS17245	COG0789	Transcriptional regulator
D3868_RS17250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3868_RS17260	COG2860	membrane
D3868_RS17265	COG1741	Belongs to the pirin family
D3868_RS17290	COG2217	Heavy metal translocating P-type atpase
D3868_RS17305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D3868_RS17320	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3868_RS17325	COG0741	lytic transglycosylase activity
D3868_RS17330	COG1573	uracil-dna glycosylase
D3868_RS17355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_RS17405	COG4520	surface antigen
D3868_RS17475	COG0583	DNA-binding transcription factor activity
D3868_RS17485	COG1283	sodium-dependent phosphate transmembrane transporter activity
D3868_RS17510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_RS17545	COG0306	phosphate transporter
D3868_RS17550	COG1392	Phosphate transport regulator
D3868_RS17560	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3868_RS17570	COG2223	nitrite transmembrane transporter activity
D3868_RS17605	COG0612	Peptidase, M16
D3868_RS17615	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D3868_RS17635	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3868_RS17645	COG0488	(ABC) transporter
D3868_RS17660	COG2249	NAD(P)H dehydrogenase (quinone) activity
D3868_RS17665	COG0583	DNA-binding transcription factor activity
D3868_RS17670	COG3135	benzoate transporter
D3868_RS17680	COG0505	Belongs to the CarA family
D3868_RS17685	COG0586	Pfam SNARE associated Golgi protein
D3868_RS17730	COG2884	Cell division ATP-binding protein ftsE
D3868_RS17765	COG5001	Diguanylate cyclase
D3868_RS17775	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3868_RS17780	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3868_RS17785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_RS17785	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3868_RS17795	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D3868_RS17805	COG2308	Evidence 4 Homologs of previously reported genes of
D3868_RS17810	COG1360	Flagellar Motor Protein
D3868_RS17815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3868_RS17820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3868_RS17845	COG0784	Response regulator, receiver
D3868_RS17845	COG2198	Histidine kinase
D3868_RS17845	COG0643	Histidine kinase
D3868_RS17850	COG0835	chemotaxis
D3868_RS17855	COG0643	Histidine kinase
D3868_RS17855	COG2198	Histidine kinase
D3868_RS17855	COG0784	Response regulator, receiver
D3868_RS17870	COG0583	DNA-binding transcription factor activity
D3868_RS17880	COG0745	RESPONSE REGULATOR receiver
D3868_RS17900	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D3868_RS17915	COG0552	protein localization to endoplasmic reticulum
D3868_RS17920	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3868_RS17925	COG2204	response regulator
D3868_RS17930	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D3868_RS17935	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3868_RS17945	COG1766	The M ring may be actively involved in energy transduction
D3868_RS17950	COG1396	sequence-specific DNA binding
D3868_RS17960	COG2205	protein histidine kinase activity
D3868_RS17965	COG2373	Large extracellular alpha-helical protein
D3868_RS17985	COG1024	Enoyl-CoA hydratase
D3868_RS17985	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3868_RS17990	COG1960	acyl-CoA dehydrogenase activity
D3868_RS18005	COG3047	cAMP biosynthetic process
D3868_RS18020	COG1196	nuclear chromosome segregation
D3868_RS18035	COG1194	a g-specific adenine glycosylase
D3868_RS18060	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D3868_RS18070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_RS18070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3868_RS18075	COG3012	SEC-C Motif Domain Protein
D3868_RS18085	COG0793	Belongs to the peptidase S41A family
D3868_RS18095	COG0309	Hydrogenase expression formation protein (HypE)
D3868_RS18100	COG0298	carbon dioxide binding
D3868_RS18105	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D3868_RS18110	COG1280	lysine exporter protein (LysE YggA)
D3868_RS18120	COG0375	protein maturation
D3868_RS18135	COG0298	carbon dioxide binding
D3868_RS18155	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3868_RS18160	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D3868_RS18165	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D3868_RS18170	COG5557	Pfam Polysulphide reductase, NrfD
D3868_RS18175	COG0437	4 iron, 4 sulfur cluster binding
D3868_RS18180	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D3868_RS18195	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D3868_RS18225	COG0625	glutathione transferase activity
D3868_RS18230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3868_RS18250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3868_RS18250	COG2813	Specifically methylates the guanine in position
D3868_RS18255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3868_RS18265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3868_RS18270	COG0287	Prephenate dehydrogenase
D3868_RS18275	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D3868_RS18285	COG0583	DNA-binding transcription factor activity
D3868_RS18295	COG3634	alkyl hydroperoxide reductase activity
D3868_RS18300	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3868_RS18305	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3868_RS18310	COG2080	2 iron, 2 sulfur cluster binding
D3868_RS18320	COG1988	membrane-bound metal-dependent
D3868_RS18340	COG0745	RESPONSE REGULATOR receiver
D3868_RS18350	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3868_RS18355	COG0540	Belongs to the ATCase OTCase family
D3868_RS18370	COG0583	DNA-binding transcription factor activity
D3868_RS18400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D3868_RS18410	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3868_RS18415	COG0154	amidase activity
D3868_RS18420	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3868_RS18425	COG4191	Histidine kinase
D3868_RS18455	COG1794	racemase activity, acting on amino acids and derivatives
D3868_RS18465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3868_RS18470	COG4770	biotin carboxylase activity
D3868_RS18475	COG1268	BioY protein
D3868_RS18480	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3868_RS18480	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3868_RS18495	COG2204	response regulator
D3868_RS18500	COG4191	Histidine kinase
D3868_RS18505	COG1301	dicarboxylic acid transport
D3868_RS18510	COG0281	malic enzyme
D3868_RS18510	COG0280	phosphate acetyltransferase
D3868_RS18515	COG0457	Tetratricopeptide repeat
D3868_RS18515	COG0859	PFAM glycosyl transferase family 9
D3868_RS18525	COG2995	paraquat-inducible protein a
D3868_RS18530	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D3868_RS18530	COG3008	intermembrane lipid transfer
D3868_RS18540	COG1882	Formate acetyltransferase
D3868_RS18550	COG1595	DNA-templated transcription, initiation
D3868_RS18555	COG3806	Anti-sigma factor
D3868_RS18560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3868_RS18720	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D3868_RS18775	COG5002	protein histidine kinase activity
D3868_RS18785	COG1472	Belongs to the glycosyl hydrolase 3 family
D3868_RS18810	COG2267	carboxylic ester hydrolase activity
D3868_RS18825	COG1454	alcohol dehydrogenase
D3868_RS18830	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3868_RS18840	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_RS18860	COG0148	phosphopyruvate hydratase activity
D3868_RS18895	COG0357	Ribosomal RNA small subunit methyltransferase G
D3868_RS18895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3868_RS18905	COG3813	Protein conserved in bacteria
D3868_RS18915	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D3868_RS18940	COG1247	-acetyltransferase
D3868_RS18945	COG0519	Catalyzes the synthesis of GMP from XMP
D3868_RS18960	COG3328	transposase activity
D3868_RS18970	COG0583	DNA-binding transcription factor activity
D3868_RS18990	COG0667	Aldo Keto reductase
D3868_RS18995	COG0583	DNA-binding transcription factor activity
D3868_RS19035	COG2703	oxygen carrier activity
D3868_RS19050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D3868_RS19055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3868_RS19060	COG1127	ABC transporter
D3868_RS19080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3868_RS19085	COG1271	oxidase subunit
D3868_RS19090	COG1294	oxidase, subunit
D3868_RS19120	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS19145	COG2089	acid synthase
D3868_RS19150	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
D3868_RS19180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3868_RS19200	COG0859	PFAM glycosyl transferase family 9
D3868_RS19200	COG0457	Tetratricopeptide repeat
D3868_RS19215	COG0859	PFAM glycosyl transferase family 9
D3868_RS19215	COG0457	Tetratricopeptide repeat
D3868_RS19235	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3868_RS19265	COG0784	Response regulator, receiver
D3868_RS19295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3868_RS19305	COG1228	amidohydrolase
D3868_RS19320	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D3868_RS19335	COG2226	methyltransferase
D3868_RS19350	COG0747	negative chemotaxis
D3868_RS19355	COG0601	transmembrane transport
D3868_RS19360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3868_RS19365	COG0444	Belongs to the ABC transporter superfamily
D3868_RS19370	COG4608	Belongs to the ABC transporter superfamily
D3868_RS19405	COG1666	GTP binding
D3868_RS19430	COG5001	Diguanylate cyclase
D3868_RS19460	COG1752	Esterase of the alpha-beta hydrolase superfamily
D3868_RS19465	COG1132	(ABC) transporter
D3868_RS19470	COG4191	Histidine kinase
D3868_RS19495	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D3868_RS19505	COG2264	protein methyltransferase activity
D3868_RS19510	COG0583	DNA-binding transcription factor activity
D3868_RS19515	COG0655	NAD(P)H dehydrogenase (quinone) activity
D3868_RS19520	COG0435	Glutathione S-transferase
D3868_RS19530	COG2197	response regulator
D3868_RS19540	COG0492	ferredoxin-NADP+ reductase activity
D3868_RS19560	COG0484	heat shock protein binding
D3868_RS19570	COG0501	Belongs to the peptidase M48B family
D3868_RS19580	COG3038	cytochrome b561
D3868_RS19585	COG3240	lipase activity
D3868_RS19600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3868_RS19610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3868_RS19620	COG1846	Transcriptional regulator
D3868_RS19630	COG3920	Histidine kinase
D3868_RS19650	COG1758	RNA polymerase activity
D3868_RS19665	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D3868_RS19670	COG0736	holo-[acyl-carrier-protein] synthase activity
D3868_RS19675	COG0681	Belongs to the peptidase S26 family
D3868_RS19680	COG0571	ribonuclease III activity
D3868_RS19685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D3868_RS19695	COG3768	UPF0283 membrane protein
D3868_RS19715	COG0740	serine-type endopeptidase activity
D3868_RS19720	COG1216	Glycosyl transferase, family 2
D3868_RS19725	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3868_RS19730	COG1566	PFAM secretion protein HlyD family protein
D3868_RS19735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3868_RS19745	COG2308	Evidence 4 Homologs of previously reported genes of
D3868_RS19745	COG2307	Protein conserved in bacteria
D3868_RS19750	COG2010	Cytochrome c
D3868_RS19770	COG2017	converts alpha-aldose to the beta-anomer
D3868_RS19775	COG2815	serine threonine protein kinase
D3868_RS19775	COG0515	serine threonine protein kinase
D3868_RS19810	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D3868_RS19820	COG0513	Belongs to the DEAD box helicase family
D3868_RS19830	COG0596	Alpha beta hydrolase
D3868_RS19840	COG0187	DNA topoisomerase II activity
D3868_RS19845	COG1607	acyl-coa hydrolase
D3868_RS19850	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D3868_RS19855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3868_RS19860	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3868_RS19860	COG0022	dehydrogenase e1 component
D3868_RS19865	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3868_RS19870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3868_RS19875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D3868_RS19880	COG2867	negative regulation of translational initiation
D3868_RS19920	COG2204	response regulator
D3868_RS19930	COG0569	domain protein
D3868_RS19945	COG1923	regulation of RNA biosynthetic process
D3868_RS19950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3868_RS19965	COG0483	inositol monophosphate 1-phosphatase activity
D3868_RS19980	COG3956	TIGRFAM MazG family protein
D3868_RS19985	COG3260	NADH ubiquinone oxidoreductase 20
D3868_RS19990	COG0649	NAD binding
D3868_RS19995	COG0651	ATP synthesis coupled electron transport
D3868_RS20005	COG0650	Formate hydrogenlyase subunit 4
D3868_RS20010	COG0651	ATP synthesis coupled electron transport
D3868_RS20020	COG2183	response to ionizing radiation
D3868_RS20030	COG1280	lysine exporter protein (LysE YggA)
D3868_RS20060	COG0393	Putative heavy-metal-binding
D3868_RS20065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3868_RS20080	COG4166	transmembrane transport
D3868_RS20085	COG0625	glutathione transferase activity
D3868_RS20090	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3868_RS20095	COG0366	Alpha amylase catalytic
D3868_RS20115	COG0840	transmembrane signaling receptor activity
D3868_RS20150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3868_RS20160	COG0583	DNA-binding transcription factor activity
D3868_RS20165	COG4336	lyase activity
D3868_RS20180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_RS20185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D3868_RS20190	COG1984	allophanate hydrolase subunit 2
D3868_RS20195	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D3868_RS20210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D3868_RS20220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3868_RS20225	COG0058	SHG alpha-glucan phosphorylase activity
D3868_RS20280	COG5002	protein histidine kinase activity
D3868_RS20285	COG0745	RESPONSE REGULATOR receiver
D3868_RS20320	COG0719	Fe-S assembly protein
D3868_RS20325	COG0396	ATPase activity
D3868_RS20330	COG0719	Fe-S assembly protein
D3868_RS20335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3868_RS20340	COG0822	iron-sulfur transferase activity
D3868_RS20350	COG0316	Belongs to the HesB IscA family
D3868_RS20360	COG0308	aminopeptidase N
D3868_RS20380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D3868_RS20415	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3868_RS20420	COG0697	spore germination
D3868_RS20430	COG2814	Major facilitator Superfamily
D3868_RS20435	COG0583	DNA-binding transcription factor activity
D3868_RS20450	COG3383	formate dehydrogenase (NAD+) activity
D3868_RS20455	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3868_RS20470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3868_RS20475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3868_RS20495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3868_RS20505	COG0129	dihydroxy-acid dehydratase activity
D3868_RS20540	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D3868_RS20545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3868_RS20550	COG0534	Mate efflux family protein
D3868_RS20585	COG0629	single-stranded DNA binding
D3868_RS20590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3868_RS20610	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D3868_RS20625	COG1562	ergosterol biosynthetic process
D3868_RS20630	COG1562	ergosterol biosynthetic process
D3868_RS20635	COG1233	COG1233 Phytoene dehydrogenase and related
D3868_RS20645	COG3737	Protein of unknown function (DUF498/DUF598)
D3868_RS20655	COG1862	Preprotein translocase
D3868_RS20675	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3868_RS20685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3868_RS20695	COG0805	protein transport
D3868_RS20700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3868_RS20705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3868_RS20710	COG3842	ATPase activity
D3868_RS20715	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D3868_RS20720	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D3868_RS20725	COG1994	Peptidase M50
D3868_RS20730	COG1472	Belongs to the glycosyl hydrolase 3 family
D3868_RS20745	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D3868_RS20750	COG0316	Belongs to the HesB IscA family
D3868_RS20755	COG0708	Exodeoxyribonuclease III
D3868_RS20775	COG0066	3-isopropylmalate dehydratase activity
D3868_RS20780	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3868_RS20785	COG1053	succinate dehydrogenase
D3868_RS20790	COG1335	isochorismatase
D3868_RS20830	COG0683	leucine binding
D3868_RS20835	COG2188	Transcriptional regulator
D3868_RS20840	COG0717	Belongs to the dCTP deaminase family
D3868_RS20855	COG0730	response to heat
D3868_RS20860	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS20880	COG0303	'Molybdopterin
D3868_RS20885	COG0765	amino acid transport
D3868_RS20890	COG0765	amino acid transport
D3868_RS20895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_RS20900	COG1126	abc transporter atp-binding protein
D3868_RS20905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3868_RS20910	COG1609	Transcriptional regulator
D3868_RS20915	COG3971	2-oxopent-4-enoate hydratase activity
D3868_RS20925	COG3265	gluconokinase activity
D3868_RS20930	COG1609	Transcriptional regulator
D3868_RS20935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D3868_RS20940	COG1024	Enoyl-CoA hydratase
D3868_RS20955	COG1652	LysM domain
D3868_RS20965	COG1174	glycine betaine transport
D3868_RS20970	COG1125	glycine betaine transport
D3868_RS20975	COG1174	glycine betaine transport
D3868_RS20980	COG1732	Glycine betaine
D3868_RS20985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D3868_RS20995	COG3842	ATPase activity
D3868_RS21010	COG0581	inorganic phosphate transmembrane transporter activity
D3868_RS21045	COG0745	RESPONSE REGULATOR receiver
D3868_RS21050	COG2205	protein histidine kinase activity
D3868_RS21050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_RS21085	COG2814	Major facilitator Superfamily
D3868_RS21105	COG0758	DNA mediated transformation
D3868_RS21110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3868_RS21125	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3868_RS21135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_RS21140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_RS21145	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3868_RS21150	COG1737	Transcriptional regulator
D3868_RS21150	COG0837	glucose binding
D3868_RS21155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3868_RS21165	COG0386	Belongs to the glutathione peroxidase family
D3868_RS21180	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D3868_RS21180	COG3264	Mechanosensitive ion channel
D3868_RS21220	COG0657	acetylesterase activity
D3868_RS21230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3868_RS21235	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D3868_RS21245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_RS21250	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3868_RS21265	COG0437	4 iron, 4 sulfur cluster binding
D3868_RS21300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3868_RS21305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3868_RS21310	COG1845	cytochrome c oxidase, subunit III
D3868_RS21355	COG0601	transmembrane transport
D3868_RS21360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3868_RS21365	COG0444	Belongs to the ABC transporter superfamily
D3868_RS21390	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D3868_RS21395	COG1902	pentaerythritol trinitrate reductase activity
D3868_RS21395	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3868_RS21410	COG2204	response regulator
D3868_RS21410	COG5564	TIM-barrel signal transduction protein
D3868_RS21415	COG5441	Belongs to the UPF0261 family
D3868_RS21420	COG5564	TIM-barrel signal transduction protein
D3868_RS21445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D3868_RS21470	COG0557	exoribonuclease II activity
D3868_RS21475	COG0793	Belongs to the peptidase S41A family
D3868_RS21480	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D3868_RS21495	COG2205	protein histidine kinase activity
D3868_RS21495	COG2202	Pas domain
D3868_RS21500	COG3447	MASE1 domain protein
D3868_RS21500	COG5001	Diguanylate cyclase
D3868_RS21500	COG5002	protein histidine kinase activity
D3868_RS21520	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D3868_RS21525	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D3868_RS21535	COG0248	Ppx GppA phosphatase
D3868_RS21540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D3868_RS21550	COG3025	triphosphatase activity
D3868_RS21555	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS21565	COG0628	permease
D3868_RS21570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3868_RS21580	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D3868_RS21585	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D3868_RS21600	COG0105	UTP biosynthetic process
D3868_RS21605	COG0488	(ABC) transporter
D3868_RS21610	COG3932	Exopolysaccharide synthesis, ExoD
D3868_RS21615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3868_RS21620	COG0300	oxidoreductase activity
D3868_RS21625	COG1561	YicC-like family, N-terminal region
D3868_RS21650	COG0741	lytic transglycosylase activity
D3868_RS21680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3868_RS21685	COG2927	DNA polymerase III (CHI subunit)
D3868_RS21690	COG2205	protein histidine kinase activity
D3868_RS21710	COG0556	nucleotide-excision repair
D3868_RS21725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3868_RS21730	COG1846	Transcriptional regulator
D3868_RS21735	COG1278	Cold shock
D3868_RS21745	COG0745	RESPONSE REGULATOR receiver
D3868_RS21760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3868_RS21790	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3868_RS21820	COG0183	Belongs to the thiolase family
D3868_RS21830	COG1082	Xylose isomerase domain protein TIM barrel
D3868_RS21850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_RS21855	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS21875	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3868_RS21875	COG0596	Alpha beta hydrolase
D3868_RS21880	COG0022	dehydrogenase e1 component
D3868_RS21885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3868_RS21890	COG3199	ATP-NAD kinase
D3868_RS21895	COG3284	Transcriptional regulator
D3868_RS21910	COG1396	sequence-specific DNA binding
D3868_RS21945	COG0300	oxidoreductase activity
D3868_RS21960	COG0583	DNA-binding transcription factor activity
D3868_RS21970	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D3868_RS21980	COG1846	Transcriptional regulator
D3868_RS21985	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS21995	COG0583	DNA-binding transcription factor activity
D3868_RS22010	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D3868_RS22020	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D3868_RS22040	COG0425	Belongs to the sulfur carrier protein TusA family
D3868_RS22050	COG0640	Transcriptional regulator
D3868_RS22070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D3868_RS22070	COG2857	Cytochrome c1
D3868_RS22085	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D3868_RS22090	COG0408	coproporphyrinogen oxidase activity
D3868_RS22095	COG0617	tRNA 3'-terminal CCA addition
D3868_RS22115	COG0714	Associated with various cellular activities
D3868_RS22230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3868_RS22235	COG1960	acyl-CoA dehydrogenase activity
D3868_RS22240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3868_RS22245	COG1764	response to oxidative stress
D3868_RS22290	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS22315	COG0583	DNA-binding transcription factor activity
D3868_RS22325	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D3868_RS22345	COG1573	uracil-dna glycosylase
D3868_RS22370	COG2010	Cytochrome c
D3868_RS22430	COG1131	(ABC) transporter
D3868_RS22450	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
D3868_RS22455	COG1229	Formylmethanofuran dehydrogenase subunit A
D3868_RS22465	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3868_RS22475	COG0702	epimerase
D3868_RS22485	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
D3868_RS22490	COG0189	ligase activity
D3868_RS22500	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
D3868_RS22595	COG1414	Transcriptional regulator
D3868_RS22600	COG1024	Enoyl-CoA hydratase
D3868_RS22610	COG3842	ATPase activity
D3868_RS22615	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_RS22620	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_RS22625	COG0840	transmembrane signaling receptor activity
D3868_RS22650	COG0402	S-adenosylhomocysteine deaminase activity
D3868_RS22655	COG1116	anion transmembrane transporter activity
D3868_RS22660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_RS22680	COG3842	ATPase activity
D3868_RS22690	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_RS22700	COG2351	hydroxyisourate hydrolase activity
D3868_RS22710	COG0154	amidase activity
D3868_RS22715	COG0784	Response regulator, receiver
D3868_RS22715	COG5002	protein histidine kinase activity
D3868_RS22755	COG3387	PFAM Glycoside hydrolase 15-related
D3868_RS22770	COG2197	response regulator
D3868_RS22775	COG2197	response regulator
D3868_RS22790	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3868_RS22795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3868_RS22800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3868_RS22805	COG0438	transferase activity, transferring glycosyl groups
D3868_RS22825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3868_RS22845	COG0438	transferase activity, transferring glycosyl groups
D3868_RS22860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3868_RS22875	COG0583	DNA-binding transcription factor activity
D3868_RS22880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3868_RS22895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3868_RS22900	COG4172	Belongs to the ABC transporter superfamily
D3868_RS22920	COG0028	Belongs to the TPP enzyme family
D3868_RS22925	COG3246	L-lysine catabolic process to acetate
D3868_RS22940	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_RS22945	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_RS22955	COG1850	ribulose-bisphosphate carboxylase activity
D3868_RS22965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_RS22970	COG2204	response regulator
D3868_RS22995	COG0670	Belongs to the BI1 family
D3868_RS23010	COG4459	periplasmic nitrate reductase
D3868_RS23035	COG3005	denitrification pathway
D3868_RS23070	COG1845	cytochrome c oxidase, subunit III
D3868_RS23075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3868_RS23080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3868_RS23085	COG0477	Major facilitator Superfamily
D3868_RS23095	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D3868_RS23125	COG0392	lysyltransferase activity
D3868_RS23130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3868_RS23180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3868_RS23200	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3868_RS23205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_RS23225	COG1846	Transcriptional regulator
D3868_RS23230	COG1764	response to oxidative stress
D3868_RS23250	COG2113	Glycine betaine
D3868_RS23255	COG4176	ABC-type proline glycine betaine transport system permease component
D3868_RS23260	COG4175	Glycine betaine
D3868_RS23265	COG0339	signal peptide processing
D3868_RS23295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_RS23300	COG0765	amino acid transport
D3868_RS23350	COG0840	transmembrane signaling receptor activity
D3868_RS23355	COG4178	(ABC) transporter
D3868_RS23365	COG1475	DNA binding
D3868_RS23370	COG1192	Involved in chromosome partitioning
D3868_RS23395	COG3622	Belongs to the hyi family
D3868_RS23405	COG1215	transferase activity, transferring glycosyl groups
D3868_RS23420	COG3307	-O-antigen
D3868_RS23425	COG0489	protein tyrosine kinase activity
D3868_RS23425	COG3206	protein involved in exopolysaccharide biosynthesis
D3868_RS23455	COG1216	Glycosyl transferase, family 2
D3868_RS23525	COG0640	Transcriptional regulator
D3868_RS23530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3868_RS23550	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3868_RS23560	COG4566	intracellular signal transduction
D3868_RS23575	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS23595	COG1994	Peptidase M50
D3868_RS23595	COG0517	IMP dehydrogenase activity
D3868_RS23605	COG1959	2 iron, 2 sulfur cluster binding
D3868_RS23615	COG1522	sequence-specific DNA binding
D3868_RS23625	COG0583	DNA-binding transcription factor activity
D3868_RS23630	COG1802	Transcriptional regulator
D3868_RS23635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_RS23645	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3868_RS23645	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_RS23650	COG2354	Protein conserved in bacteria
D3868_RS23670	COG1418	mRNA catabolic process
D3868_RS23675	COG1131	(ABC) transporter
D3868_RS23680	COG0842	Transport permease protein
D3868_RS23685	COG3791	Glutathione-dependent formaldehyde-activating
D3868_RS23690	COG0154	amidase activity
D3868_RS23695	COG0154	amidase activity
D3868_RS23700	COG1335	isochorismatase
D3868_RS23705	COG0747	negative chemotaxis
D3868_RS23710	COG0601	transmembrane transport
D3868_RS23715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3868_RS23725	COG4608	Belongs to the ABC transporter superfamily
D3868_RS23730	COG1335	isochorismatase
D3868_RS23735	COG3180	Ammonia monooxygenase
D3868_RS23740	COG1802	Transcriptional regulator
D3868_RS23750	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D3868_RS23755	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D3868_RS23760	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D3868_RS23765	COG2205	protein histidine kinase activity
D3868_RS23775	COG0861	Integral membrane protein TerC family
D3868_RS23785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_RS23790	COG2353	YceI-like domain
D3868_RS23815	COG4566	intracellular signal transduction
D3868_RS23820	COG4566	intracellular signal transduction
D3868_RS23825	COG4191	Histidine kinase
D3868_RS23840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3868_RS23845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3868_RS23850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_RS23860	COG0427	acetyl-CoA hydrolase
D3868_RS23885	COG0243	molybdopterin cofactor binding
D3868_RS23975	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3868_RS23985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_RS23990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3868_RS24000	COG0628	permease
D3868_RS24005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D3868_RS24015	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D3868_RS24055	COG1653	transport
D3868_RS24070	COG3842	ATPase activity
D3868_RS24095	COG0840	transmembrane signaling receptor activity
D3868_RS24095	COG0840	transmembrane signaling receptor activity
D3868_RS24135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3868_RS24140	COG1473	amidohydrolase
D3868_RS24155	COG4122	O-methyltransferase activity
D3868_RS24185	COG1971	Probably functions as a manganese efflux pump
D3868_RS24190	COG0840	transmembrane signaling receptor activity
D3868_RS24190	COG3290	protein histidine kinase activity
D3868_RS24215	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS24220	COG0366	Alpha amylase catalytic
D3868_RS24225	COG2388	GCN5-related N-acetyl-transferase
D3868_RS24240	COG0784	Response regulator, receiver
D3868_RS24240	COG4191	Histidine kinase
D3868_RS24245	COG0784	Response regulator, receiver
D3868_RS24245	COG5002	protein histidine kinase activity
D3868_RS24305	COG4615	Cyclic peptide transporter
D3868_RS24330	COG0586	Pfam SNARE associated Golgi protein
D3868_RS24355	COG0395	ABC-type sugar transport system, permease component
D3868_RS24370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D3868_RS24375	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS24400	COG2095	MarC family integral membrane protein
D3868_RS24415	COG0840	transmembrane signaling receptor activity
D3868_RS24420	COG0835	chemotaxis
D3868_RS24425	COG2201	protein-glutamate methylesterase activity
D3868_RS24435	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D3868_RS24445	COG2198	Histidine kinase
D3868_RS24445	COG0643	Histidine kinase
D3868_RS24455	COG2197	response regulator
D3868_RS24470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3868_RS24480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3868_RS24510	COG2204	response regulator
D3868_RS24520	COG2985	domain, Protein
D3868_RS24535	COG3842	ATPase activity
D3868_RS24550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3868_RS24560	COG0251	oxidation-reduction process
D3868_RS24570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3868_RS24580	COG0747	negative chemotaxis
D3868_RS24590	COG0583	DNA-binding transcription factor activity
D3868_RS24600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3868_RS24605	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3868_RS24605	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3868_RS24610	COG1660	Displays ATPase and GTPase activities
D3868_RS24625	COG0642	Histidine kinase
D3868_RS24630	COG0745	RESPONSE REGULATOR receiver
D3868_RS24645	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D3868_RS24660	COG0739	heme binding
D3868_RS24710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3868_RS24730	COG1216	Glycosyl transferase, family 2
D3868_RS24730	COG1442	glycosyl transferase family 8
D3868_RS24740	COG4178	(ABC) transporter
D3868_RS24750	COG2723	6-phospho-beta-galactosidase activity
D3868_RS24755	COG2723	6-phospho-beta-galactosidase activity
D3868_RS24775	COG2819	hydrolase of the alpha beta superfamily
D3868_RS24805	COG4770	biotin carboxylase activity
D3868_RS24810	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D3868_RS24815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3868_RS24820	COG1960	acyl-CoA dehydrogenase activity
D3868_RS24825	COG0183	Belongs to the thiolase family
D3868_RS24830	COG1960	acyl-CoA dehydrogenase activity
D3868_RS24840	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_RS24875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3868_RS24880	COG0747	negative chemotaxis
D3868_RS24890	COG2201	protein-glutamate methylesterase activity
D3868_RS24910	COG4771	TonB-dependent receptor
D3868_RS24935	COG1169	isochorismate synthase
D3868_RS24940	COG1021	2,3-dihydroxybenzoate-AMP ligase
D3868_RS24945	COG3433	isochorismatase activity
D3868_RS24945	COG1535	isochorismatase
D3868_RS24950	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS24960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3868_RS24965	COG2382	esterase
D3868_RS24975	COG1960	acyl-CoA dehydrogenase activity
D3868_RS24980	COG2186	Transcriptional regulator
D3868_RS24985	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_RS24990	COG1309	transcriptional regulator
D3868_RS25000	COG1846	Transcriptional regulator
D3868_RS25005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D3868_RS25015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_RS25035	COG2226	methyltransferase
D3868_RS25100	COG0861	Integral membrane protein TerC family
D3868_RS25110	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D3868_RS25110	COG0517	IMP dehydrogenase activity
D3868_RS25110	COG0617	tRNA 3'-terminal CCA addition
D3868_RS25115	COG1802	Transcriptional regulator
D3868_RS25155	COG0367	asparagine synthase
D3868_RS25160	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3868_RS25160	COG2918	glutathione biosynthetic process
D3868_RS25165	COG1363	Peptidase, m42
D3868_RS25175	COG1966	Carbon starvation protein
D3868_RS25190	COG3275	phosphorelay sensor kinase activity
D3868_RS25235	COG0848	biopolymer transport protein
D3868_RS25245	COG4566	intracellular signal transduction
D3868_RS25250	COG4191	Histidine kinase
D3868_RS25255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D3868_RS25295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_RS25305	COG5002	protein histidine kinase activity
D3868_RS25305	COG2205	protein histidine kinase activity
D3868_RS25305	COG0784	Response regulator, receiver
D3868_RS25330	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS25355	COG0800	Aldolase
D3868_RS25360	COG3734	2-keto-3-deoxy-galactonokinase
D3868_RS25365	COG1414	Transcriptional regulator
D3868_RS25370	COG0542	response to heat
D3868_RS25375	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3868_RS25385	COG2186	Transcriptional regulator
D3868_RS25390	COG1620	l-lactate permease
D3868_RS25395	COG0277	FAD linked oxidase domain protein
D3868_RS25400	COG0247	lactate metabolic process
D3868_RS25405	COG1139	Iron-sulfur cluster binding protein
D3868_RS25445	COG0668	transmembrane transport
D3868_RS25515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3868_RS25555	COG1902	pentaerythritol trinitrate reductase activity
D3868_RS25580	COG0673	inositol 2-dehydrogenase activity
D3868_RS25590	COG1053	succinate dehydrogenase
D3868_RS25595	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3868_RS25600	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS25630	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS25645	COG0625	glutathione transferase activity
D3868_RS25660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3868_RS25730	COG4372	Transposase
D3868_RS25735	COG3436	PFAM IS66 Orf2 family protein
D3868_RS25775	COG0604	alcohol dehydrogenase
D3868_RS25780	COG1024	Enoyl-CoA hydratase
D3868_RS25785	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_RS25795	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_RS25805	COG3842	ATPase activity
D3868_RS25835	COG0798	PFAM Bile acid sodium symporter
D3868_RS25840	COG0431	NADPH-dependent FMN reductase
D3868_RS25875	COG1120	ATPase activity
D3868_RS25895	COG4774	siderophore transport
D3868_RS25910	COG4774	siderophore transport
D3868_RS25915	COG1595	DNA-templated transcription, initiation
D3868_RS25940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3868_RS25945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3868_RS25950	COG0405	Gamma-glutamyltransferase
D3868_RS25955	COG4336	lyase activity
D3868_RS25960	COG0251	oxidation-reduction process
D3868_RS25965	COG1522	sequence-specific DNA binding
D3868_RS25995	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS26015	COG2610	gluconate transmembrane transporter activity
D3868_RS26045	COG3920	Histidine kinase
D3868_RS26075	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_RS26080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3868_RS26095	COG0071	Belongs to the small heat shock protein (HSP20) family
D3868_RS26105	COG1802	Transcriptional regulator
D3868_RS26105	COG4626	Terminase
D3868_RS26145	COG1126	abc transporter atp-binding protein
D3868_RS26195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D3868_RS26215	COG0356	it plays a direct role in the translocation of protons across the membrane
D3868_RS26225	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3868_RS26230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D3868_RS26235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D3868_RS26245	COG1566	PFAM secretion protein HlyD family protein
D3868_RS26260	COG2207	Transcriptional regulator
D3868_RS26275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_RS26285	COG0765	amino acid transport
D3868_RS26290	COG1126	abc transporter atp-binding protein
D3868_RS26295	COG1012	belongs to the aldehyde dehydrogenase family
D3868_RS26305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D3868_RS26315	COG2721	sulfolactate sulfo-lyase activity
D3868_RS26340	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D3868_RS26360	COG1414	Transcriptional regulator
D3868_RS26370	COG0601	transmembrane transport
D3868_RS26375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3868_RS26380	COG0444	Belongs to the ABC transporter superfamily
D3868_RS26385	COG4608	Belongs to the ABC transporter superfamily
D3868_RS26400	COG4302	ethanolamine ammonia-lyase activity
D3868_RS26405	COG4303	Ethanolamine ammonia lyase large subunit
D3868_RS26410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3868_RS26435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3868_RS26445	COG0457	Tetratricopeptide repeat
D3868_RS26445	COG0859	PFAM glycosyl transferase family 9
D3868_RS26495	COG1749	Flagellar hook protein flgE
D3868_RS26500	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D3868_RS26515	COG0667	Aldo Keto reductase
D3868_RS26535	COG4772	TonB-dependent receptor
D3868_RS26560	COG4251	negative regulation of phosphorylation
D3868_RS26565	COG0745	RESPONSE REGULATOR receiver
D3868_RS26570	COG0745	RESPONSE REGULATOR receiver
D3868_RS26585	COG2080	2 iron, 2 sulfur cluster binding
D3868_RS26590	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3868_RS26595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3868_RS26605	COG2814	Major facilitator Superfamily
D3868_RS26620	COG0583	DNA-binding transcription factor activity
D3868_RS26665	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3868_RS26670	COG1024	Enoyl-CoA hydratase
D3868_RS26675	COG0022	dehydrogenase e1 component
D3868_RS26675	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3868_RS26680	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3868_RS26690	COG0683	leucine binding
D3868_RS26720	COG4221	oxidoreductase activity
D3868_RS26725	COG2814	Major facilitator Superfamily
D3868_RS26740	COG4774	siderophore transport
D3868_RS26755	COG1802	Transcriptional regulator
D3868_RS26760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_RS26765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3868_RS26770	COG4948	Mandelate Racemase Muconate Lactonizing
D3868_RS26775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_RS26785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D3868_RS26805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3868_RS26810	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_RS26815	COG3842	ATPase activity
D3868_RS26825	COG0277	FAD linked oxidase domain protein
D3868_RS26835	COG0842	Transport permease protein
D3868_RS26840	COG0842	Transport permease protein
D3868_RS26840	COG1129	ABC transporter
D3868_RS26845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_RS26850	COG1940	carbohydrate kinase activity
D3868_RS26860	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3868_RS26865	COG1879	ABC-type sugar transport system periplasmic component
D3868_RS26875	COG0673	inositol 2-dehydrogenase activity
D3868_RS26880	COG2115	Belongs to the xylose isomerase family
D3868_RS26885	COG1070	Carbohydrate kinase
D3868_RS26890	COG0583	DNA-binding transcription factor activity
D3868_RS26900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3868_RS26900	COG1017	nitric oxide dioxygenase activity
D3868_RS26905	COG0625	glutathione transferase activity
D3868_RS26910	COG1802	Transcriptional regulator
D3868_RS26920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3868_RS26965	COG3842	ATPase activity
D3868_RS26970	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_RS26975	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_RS26980	COG3938	Belongs to the proline racemase family
D3868_RS26985	COG1802	Transcriptional regulator
D3868_RS26990	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D3868_RS26995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3868_RS27000	COG0066	3-isopropylmalate dehydratase activity
D3868_RS27015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_RS27020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_RS27030	COG0515	serine threonine protein kinase
D3868_RS27030	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3868_RS27055	COG4302	ethanolamine ammonia-lyase activity
D3868_RS27155	COG1136	(ABC) transporter
D3868_RS27155	COG0577	efflux transmembrane transporter activity
D3868_RS27180	COG0523	cobalamin synthesis protein
D3868_RS27205	COG4977	sequence-specific DNA binding
D3868_RS27225	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS27240	COG1959	2 iron, 2 sulfur cluster binding
D3868_RS27280	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS27295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_RS27305	COG1024	Enoyl-CoA hydratase
D3868_RS27310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3868_RS27315	COG0154	amidase activity
D3868_RS27335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3868_RS27355	COG1595	DNA-templated transcription, initiation
D3868_RS27370	COG0697	spore germination
D3868_RS27385	COG2188	Transcriptional regulator
D3868_RS27415	COG1121	(ABC) transporter
D3868_RS27430	COG1136	(ABC) transporter
D3868_RS27430	COG0577	efflux transmembrane transporter activity
D3868_RS27445	COG3712	iron ion homeostasis
D3868_RS27450	COG1595	DNA-templated transcription, initiation
D3868_RS27475	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D3868_RS27575	COG0596	Alpha beta hydrolase
D3868_RS27580	COG1764	response to oxidative stress
D3868_RS27585	COG1846	Transcriptional regulator
D3868_RS27590	COG0583	DNA-binding transcription factor activity
D3868_RS27595	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS27630	COG2828	Protein conserved in bacteria
D3868_RS27650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3868_RS27660	COG3800	Transcriptional regulator
D3868_RS27660	COG1396	sequence-specific DNA binding
D3868_RS27670	COG0583	DNA-binding transcription factor activity
D3868_RS27705	COG1783	phage Terminase large subunit
D3868_RS27720	COG3250	beta-galactosidase activity
D3868_RS27725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_RS27730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_RS27730	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3868_RS27750	COG0861	Integral membrane protein TerC family
D3868_RS27755	COG0251	oxidation-reduction process
D3868_RS27765	COG0251	oxidation-reduction process
D3868_RS27770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3868_RS27790	COG1177	transmembrane transport
D3868_RS27795	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_RS27800	COG3842	ATPase activity
D3868_RS27820	COG1396	sequence-specific DNA binding
D3868_RS27830	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS27835	COG3246	L-lysine catabolic process to acetate
D3868_RS27840	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3868_RS27845	COG2204	response regulator
D3868_RS27860	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3868_RS27865	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3868_RS27870	COG1278	Cold shock
D3868_RS27880	COG4566	intracellular signal transduction
D3868_RS27880	COG0745	RESPONSE REGULATOR receiver
D3868_RS27895	COG0411	ABC transporter
D3868_RS27910	COG0683	leucine binding
D3868_RS27915	COG2814	Major facilitator Superfamily
D3868_RS28025	COG3772	lysozyme
D3868_RS28430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D3868_RS28435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3868_RS28465	COG0633	Ferredoxin
D3868_RS28470	COG2124	cytochrome p450
D3868_RS28485	COG0583	DNA-binding transcription factor activity
D3868_RS28510	COG2271	Major facilitator Superfamily
D3868_RS28515	COG0583	DNA-binding transcription factor activity
D3868_RS28545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_RS28560	COG0826	peptidase U32
D3868_RS28585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3868_RS28600	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D3868_RS28620	COG4263	nitrous-oxide reductase activity
D3868_RS28640	COG0714	Associated with various cellular activities
D3868_RS28645	COG3256	nitric oxide reductase
D3868_RS28670	COG2223	nitrite transmembrane transporter activity
D3868_RS28720	COG0489	protein tyrosine kinase activity
D3868_RS28730	COG4964	Belongs to the GSP D family
D3868_RS28765	COG1278	Cold shock
D3868_RS28775	COG0513	Belongs to the DEAD box helicase family
D3868_RS28800	COG3842	ATPase activity
D3868_RS28830	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_RS28850	COG1012	belongs to the aldehyde dehydrogenase family
D3868_RS28855	COG1024	Enoyl-CoA hydratase
D3868_RS28860	COG2186	Transcriptional regulator
D3868_RS28900	COG3436	PFAM IS66 Orf2 family protein
D3868_RS28925	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS28945	COG2207	Transcriptional regulator
D3868_RS28975	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS28980	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS28995	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS29010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_RS29025	COG1053	succinate dehydrogenase
D3868_RS29030	COG1902	pentaerythritol trinitrate reductase activity
D3868_RS29035	COG1053	succinate dehydrogenase
D3868_RS29035	COG3976	FMN-binding domain protein
D3868_RS29035	COG0431	NADPH-dependent FMN reductase
D3868_RS29055	COG0673	inositol 2-dehydrogenase activity
D3868_RS29065	COG1053	succinate dehydrogenase
D3868_RS29080	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS29170	COG1766	The M ring may be actively involved in energy transduction
D3868_RS29180	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3868_RS29185	COG1338	Plays a role in the flagellum-specific transport system
D3868_RS29195	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3868_RS29210	COG0668	transmembrane transport
D3868_RS29230	COG1012	belongs to the aldehyde dehydrogenase family
D3868_RS29365	COG4964	Belongs to the GSP D family
D3868_RS29385	COG1858	cytochrome C peroxidase
D3868_RS29415	COG0405	Gamma-glutamyltransferase
D3868_RS29435	COG2199	diguanylate cyclase activity
D3868_RS29435	COG2203	Gaf domain
D3868_RS29450	COG1132	(ABC) transporter
D3868_RS29520	COG1595	DNA-templated transcription, initiation
D3868_RS29535	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS29540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_RS29560	COG2079	MmgE PrpD family protein
D3868_RS29565	COG1960	acyl-CoA dehydrogenase activity
D3868_RS29570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3868_RS29585	COG0154	amidase activity
D3868_RS29600	COG2188	Transcriptional regulator
D3868_RS29655	COG0861	Integral membrane protein TerC family
D3868_RS29690	COG2721	sulfolactate sulfo-lyase activity
D3868_RS29695	COG1904	glucuronate isomerase
D3868_RS29705	COG1802	Transcriptional regulator
D3868_RS29710	COG0667	Aldo Keto reductase
D3868_RS29715	COG4774	siderophore transport
D3868_RS29735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_RS29745	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_RS29750	COG1917	Cupin 2, conserved barrel domain protein
D3868_RS29755	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS29760	COG1802	Transcriptional regulator
D3868_RS29775	COG0246	Mannitol dehydrogenase
D3868_RS29780	COG1312	Catalyzes the dehydration of D-mannonate
D3868_RS29820	COG2133	pyrroloquinoline quinone binding
D3868_RS29835	COG0583	DNA-binding transcription factor activity
D3868_RS29845	COG1733	regulation of RNA biosynthetic process
D3868_RS29850	COG0702	epimerase
D3868_RS29855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3868_RS29860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_RS29865	COG1309	transcriptional regulator
D3868_RS29875	COG2132	Multicopper oxidase
D3868_RS29880	COG5039	Polysaccharide pyruvyl transferase
D3868_RS29895	COG0725	ABC transporter, periplasmic molybdate-binding protein
D3868_RS29900	COG0246	Mannitol dehydrogenase
D3868_RS29925	COG4214	carbohydrate transport
D3868_RS29965	COG1879	ABC-type sugar transport system periplasmic component
D3868_RS29970	COG1129	ABC transporter
D3868_RS29975	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3868_RS29980	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3868_RS29990	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D3868_RS29995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3868_RS30005	COG1496	oxidoreductase activity
D3868_RS30025	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_RS30030	COG1278	Cold shock
D3868_RS30035	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D3868_RS30045	COG0574	Belongs to the PEP-utilizing enzyme family
D3868_RS30045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3868_RS30055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D3868_RS30060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3868_RS30065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D3868_RS30065	COG4106	trans-aconitate 2-methyltransferase activity
D3868_RS30075	COG0156	8-amino-7-oxononanoate synthase activity
D3868_RS30090	COG0564	pseudouridine synthase activity
D3868_RS30100	COG0484	heat shock protein binding
D3868_RS30135	COG1744	ABC transporter substrate-binding protein PnrA-like
D3868_RS30145	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS30155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3868_RS30160	COG4608	Belongs to the ABC transporter superfamily
D3868_RS30165	COG0444	Belongs to the ABC transporter superfamily
D3868_RS30175	COG0601	transmembrane transport
D3868_RS30180	COG0747	negative chemotaxis
D3868_RS30210	COG2239	Acts as a magnesium transporter
D3868_RS30215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3868_RS30215	COG2022	thiamine diphosphate biosynthetic process
D3868_RS30225	COG2022	thiamine diphosphate biosynthetic process
D3868_RS30280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3868_RS30285	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D3868_RS30295	COG0191	fructose-bisphosphate aldolase activity
D3868_RS30320	COG4251	negative regulation of phosphorylation
D3868_RS30325	COG0784	Response regulator, receiver
D3868_RS30365	COG1045	serine acetyltransferase
D3868_RS30390	COG3842	ATPase activity
D3868_RS30395	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_RS30400	COG1178	ABC-type Fe3 transport system permease component
D3868_RS30410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3868_RS30415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3868_RS30420	COG2233	PERMEase
D3868_RS30425	COG1254	Belongs to the acylphosphatase family
D3868_RS30440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3868_RS30445	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3868_RS30445	COG2010	Cytochrome c
D3868_RS30470	COG1131	(ABC) transporter
D3868_RS30495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3868_RS30495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3868_RS30515	COG0012	GTP binding
D3868_RS30520	COG5001	Diguanylate cyclase
D3868_RS30520	COG3300	MHYT domain
D3868_RS30530	COG0583	DNA-binding transcription factor activity
D3868_RS30535	COG2814	Major facilitator Superfamily
D3868_RS30545	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS30550	COG0183	Belongs to the thiolase family
D3868_RS30555	COG2226	methyltransferase
D3868_RS30555	COG0596	Alpha beta hydrolase
D3868_RS30555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3868_RS30650	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D3868_RS30675	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3868_RS30685	COG3845	ABC transporter
D3868_RS30690	COG4603	Belongs to the binding-protein-dependent transport system permease family
D3868_RS30695	COG1079	Belongs to the binding-protein-dependent transport system permease family
D3868_RS30700	COG0402	S-adenosylhomocysteine deaminase activity
D3868_RS30705	COG0840	transmembrane signaling receptor activity
D3868_RS30710	COG4191	Histidine kinase
D3868_RS30740	COG1414	Transcriptional regulator
D3868_RS30745	COG3383	formate dehydrogenase (NAD+) activity
D3868_RS30765	COG1597	lipid kinase activity
D3868_RS30775	COG0628	permease
D3868_RS30780	COG3416	Protein conserved in bacteria
D3868_RS30825	COG1802	Transcriptional regulator
D3868_RS30830	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D3868_RS30835	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS30845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3868_RS30855	COG0148	phosphopyruvate hydratase activity
D3868_RS30860	COG1882	Formate acetyltransferase
D3868_RS30865	COG0837	glucose binding
D3868_RS30865	COG1737	Transcriptional regulator
D3868_RS30870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3868_RS30875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_RS30880	COG1309	transcriptional regulator
D3868_RS30885	COG1309	transcriptional regulator
D3868_RS30890	COG5002	protein histidine kinase activity
D3868_RS30895	COG4251	negative regulation of phosphorylation
D3868_RS30905	COG0469	pyruvate kinase activity
D3868_RS30910	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3868_RS30915	COG2116	formate transmembrane transporter activity
D3868_RS30920	COG0697	spore germination
D3868_RS30925	COG1802	Transcriptional regulator
D3868_RS30930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_RS30940	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_RS30945	COG0861	Integral membrane protein TerC family
D3868_RS30975	COG1749	Flagellar hook protein flgE
D3868_RS30990	COG1706	bacterial-type flagellum-dependent cell motility
D3868_RS31015	COG5001	Diguanylate cyclase
D3868_RS31015	COG3300	MHYT domain
D3868_RS31040	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_RS31050	COG0793	Belongs to the peptidase S41A family
D3868_RS31055	COG5487	UPF0391 membrane protein
D3868_RS31065	COG4191	Histidine kinase
D3868_RS31075	COG0028	Belongs to the TPP enzyme family
D3868_RS31085	COG1522	sequence-specific DNA binding
D3868_RS31095	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3868_RS31100	COG1684	flagellar biosynthetic protein fliR
D3868_RS31105	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3868_RS31115	COG4794	Type iii secretion
D3868_RS31120	COG1677	Flagellar hook-basal body complex protein FliE
D3868_RS31125	COG1558	bacterial-type flagellum-dependent cell motility
D3868_RS31130	COG1815	bacterial-type flagellum-dependent cell motility
D3868_RS31150	COG2814	Major facilitator Superfamily
D3868_RS31170	COG5443	negative regulation of bacterial-type flagellum assembly
D3868_RS31180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3868_RS31205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3868_RS31210	COG1802	Transcriptional regulator
D3868_RS31225	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D3868_RS31230	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D3868_RS31235	COG1120	ATPase activity
D3868_RS31240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3868_RS31245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3868_RS31255	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D3868_RS31265	COG1845	cytochrome c oxidase, subunit III
D3868_RS31270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3868_RS31290	COG0567	Dehydrogenase, E1 component
D3868_RS31295	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3868_RS31310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3868_RS31325	COG0277	FAD linked oxidase domain protein
D3868_RS31330	COG2086	electron transfer activity
D3868_RS31355	COG0154	amidase activity
D3868_RS31415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3868_RS31435	COG0683	leucine binding
D3868_RS31465	COG3473	Maleate cis-trans isomerase
D3868_RS31470	COG0596	Alpha beta hydrolase
D3868_RS31475	COG2309	aminopeptidase activity
D3868_RS31480	COG1335	isochorismatase
D3868_RS31490	COG1609	Transcriptional regulator
D3868_RS31495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3868_RS31495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3868_RS31500	COG1105	Belongs to the carbohydrate kinase PfkB family
D3868_RS31505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3868_RS31505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3868_RS31515	COG3920	Histidine kinase
D3868_RS31520	COG2197	response regulator
D3868_RS31550	COG0583	DNA-binding transcription factor activity
D3868_RS31565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3868_RS31570	COG1473	amidohydrolase
D3868_RS31610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3868_RS31615	COG0251	oxidation-reduction process
D3868_RS31620	COG1522	sequence-specific DNA binding
D3868_RS31630	COG1414	Transcriptional regulator
D3868_RS31635	COG0280	phosphate acetyltransferase
D3868_RS31655	COG1012	belongs to the aldehyde dehydrogenase family
D3868_RS31660	COG0045	succinate-CoA ligase (ADP-forming) activity
D3868_RS31665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D3868_RS31670	COG0243	molybdopterin cofactor binding
D3868_RS31675	COG0437	4 iron, 4 sulfur cluster binding
D3868_RS31690	COG0028	Belongs to the TPP enzyme family
D3868_RS31695	COG1475	DNA binding
D3868_RS31700	COG1192	Involved in chromosome partitioning
D3868_RS31720	COG0546	phosphoglycolate phosphatase activity
D3868_RS31735	COG2855	membrane
D3868_RS31740	COG0583	DNA-binding transcription factor activity
D3868_RS31770	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D3868_RS31775	COG4191	Histidine kinase
D3868_RS31775	COG0784	Response regulator, receiver
D3868_RS31800	COG1012	belongs to the aldehyde dehydrogenase family
D3868_RS31805	COG0028	Belongs to the TPP enzyme family
D3868_RS31810	COG0583	DNA-binding transcription factor activity
D3868_RS31815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3868_RS31820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3868_RS31835	COG4221	oxidoreductase activity
D3868_RS31865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3868_RS31930	COG1454	alcohol dehydrogenase
D3868_RS31930	COG1012	belongs to the aldehyde dehydrogenase family
D3868_RS32005	COG1360	Flagellar Motor Protein
D3868_RS32010	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D3868_RS32020	COG4786	Flagellar basal body rod
D3868_RS32025	COG4786	Flagellar basal body rod
D3868_RS32030	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
D3868_RS32035	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D3868_RS32055	COG0243	molybdopterin cofactor binding
D3868_RS32065	COG3005	denitrification pathway
D3868_RS32120	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3868_RS32200	COG0438	transferase activity, transferring glycosyl groups
D3868_RS32205	COG1215	transferase activity, transferring glycosyl groups
D3868_RS32215	COG0463	Glycosyl transferase, family 2
D3868_RS32255	COG0438	transferase activity, transferring glycosyl groups
D3868_RS32260	COG0438	transferase activity, transferring glycosyl groups
D3868_RS32260	COG1216	Glycosyl transferase, family 2
D3868_RS32270	COG0438	transferase activity, transferring glycosyl groups
D3868_RS32290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3868_RS32300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3868_RS32325	COG1088	dTDP-glucose 4,6-dehydratase activity
D3868_RS32350	COG0528	UMP kinase activity
D3868_RS32355	COG0528	UMP kinase activity
D3868_RS32375	COG1051	belongs to the nudix hydrolase family
D3868_RS32390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3868_RS32400	COG1086	Polysaccharide biosynthesis protein
D3868_RS32415	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3868_RS32425	COG1475	DNA binding
D3868_RS32430	COG1192	Involved in chromosome partitioning
D3868_RS32455	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D3868_RS32465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3868_RS32505	COG1215	transferase activity, transferring glycosyl groups
D3868_RS32515	COG0297	glycogen (starch) synthase activity
D3868_RS32580	COG3754	Rhamnan synthesis protein F
D3868_RS32585	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D3868_RS32605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3868_RS32620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_RS32640	COG1088	dTDP-glucose 4,6-dehydratase activity
D3868_RS32645	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D3868_RS32650	COG0297	glycogen (starch) synthase activity
D3868_RS32655	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
D3868_RS32660	COG0579	oxidoreductase
D3868_RS32665	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D3868_RS32670	COG0500	methyltransferase
D3868_RS32675	COG0438	transferase activity, transferring glycosyl groups