locus-tag	class	description
D3869_RS00010	COG2197	response regulator
D3869_RS00025	COG0829	nickel cation binding
D3869_RS00030	COG1819	glycosyl
D3869_RS00035	COG0831	urea catabolic process
D3869_RS00040	COG0832	Belongs to the urease beta subunit family
D3869_RS00045	COG0804	urea catabolic process
D3869_RS00050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D3869_RS00055	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D3869_RS00060	COG0830	nickel cation binding
D3869_RS00065	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D3869_RS00070	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
D3869_RS00080	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3869_RS00095	COG0640	Transcriptional regulator
D3869_RS00125	COG1396	sequence-specific DNA binding
D3869_RS00150	COG1846	Transcriptional regulator
D3869_RS00180	COG0463	Glycosyl transferase, family 2
D3869_RS00200	COG1940	carbohydrate kinase activity
D3869_RS00250	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D3869_RS00250	COG2885	chlorophyll binding
D3869_RS00255	COG2197	response regulator
D3869_RS00260	COG2198	Histidine kinase
D3869_RS00260	COG0784	Response regulator, receiver
D3869_RS00260	COG2205	protein histidine kinase activity
D3869_RS00275	COG0564	pseudouridine synthase activity
D3869_RS00285	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D3869_RS00285	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D3869_RS00330	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS00340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3869_RS00345	COG1763	Mo-molybdopterin cofactor biosynthetic process
D3869_RS00355	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D3869_RS00360	COG0314	molybdopterin synthase activity
D3869_RS00370	COG1280	lysine exporter protein (LysE YggA)
D3869_RS00410	COG0776	regulation of translation
D3869_RS00445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3869_RS00450	COG0174	glutamine synthetase
D3869_RS00460	COG3842	ATPase activity
D3869_RS00465	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_RS00470	COG1177	transmembrane transport
D3869_RS00475	COG2957	Belongs to the agmatine deiminase family
D3869_RS00485	COG0631	protein serine/threonine phosphatase activity
D3869_RS00500	COG0321	lipoyl(octanoyl) transferase activity
D3869_RS00500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D3869_RS00505	COG0084	hydrolase, TatD family'
D3869_RS00510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3869_RS00515	COG0470	DNA polymerase III
D3869_RS00520	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D3869_RS00525	COG1686	Belongs to the peptidase S11 family
D3869_RS00540	COG0840	transmembrane signaling receptor activity
D3869_RS00545	COG0525	valine-tRNA ligase activity
D3869_RS00555	COG1538	Outer membrane efflux protein
D3869_RS00565	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3869_RS00590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3869_RS00595	COG0494	nUDIX hydrolase
D3869_RS00610	COG2897	thiosulfate sulfurtransferase activity
D3869_RS00630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3869_RS00635	COG1126	abc transporter atp-binding protein
D3869_RS00640	COG0765	amino acid transport
D3869_RS00645	COG4597	amino acid ABC transporter
D3869_RS00650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_RS00655	COG0626	cystathionine gamma-synthase activity
D3869_RS00660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D3869_RS00705	COG0123	including yeast histone deacetylase and acetoin utilization protein
D3869_RS00735	COG2358	TRAP transporter, solute receptor (TAXI family
D3869_RS00770	COG3608	succinylglutamate desuccinylase aspartoacylase
D3869_RS00770	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D3869_RS00775	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D3869_RS00785	COG0737	Belongs to the 5'-nucleotidase family
D3869_RS00795	COG0686	Belongs to the AlaDH PNT family
D3869_RS00810	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_RS00830	COG1846	Transcriptional regulator
D3869_RS00835	COG1024	Enoyl-CoA hydratase
D3869_RS00840	COG1597	lipid kinase activity
D3869_RS00845	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3869_RS00850	COG0113	porphobilinogen synthase activity
D3869_RS00855	COG1881	PFAM PEBP family protein
D3869_RS00865	COG2813	Specifically methylates the guanine in position
D3869_RS00870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D3869_RS00875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3869_RS00880	COG0741	lytic transglycosylase activity
D3869_RS00890	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D3869_RS00895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3869_RS00910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D3869_RS00915	COG0360	Binds together with S18 to 16S ribosomal RNA
D3869_RS00920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D3869_RS00930	COG0359	binds to the 23S rRNA
D3869_RS00935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3869_RS00940	COG0305	Participates in initiation and elongation during chromosome replication
D3869_RS00945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3869_RS00950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3869_RS00955	COG1127	ABC transporter
D3869_RS00970	COG0024	Methionine aminopeptidase
D3869_RS00985	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D3869_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS00995	COG1160	GTP binding
D3869_RS01015	COG2197	response regulator
D3869_RS01025	COG2197	response regulator
D3869_RS01055	COG0840	transmembrane signaling receptor activity
D3869_RS01090	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D3869_RS01095	COG2814	Major facilitator Superfamily
D3869_RS01110	COG0789	Transcriptional regulator
D3869_RS01115	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_RS01135	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3869_RS01145	COG1116	anion transmembrane transporter activity
D3869_RS01145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3869_RS01155	COG0175	sulfate reduction
D3869_RS01160	COG0175	sulfate reduction
D3869_RS01165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3869_RS01165	COG1648	precorrin-2 dehydrogenase activity
D3869_RS01180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3869_RS01195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3869_RS01195	COG4651	solute:proton antiporter activity
D3869_RS01210	COG4372	Transposase
D3869_RS01215	COG3436	PFAM IS66 Orf2 family protein
D3869_RS01250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3869_RS01255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D3869_RS01325	COG0840	transmembrane signaling receptor activity
D3869_RS01330	COG0784	Response regulator, receiver
D3869_RS01350	COG3772	lysozyme
D3869_RS01420	COG4386	tail sheath protein
D3869_RS01560	COG1396	sequence-specific DNA binding
D3869_RS01565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D3869_RS01685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3869_RS01690	COG0416	fatty acid biosynthetic process
D3869_RS01695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D3869_RS01720	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D3869_RS01730	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D3869_RS01735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3869_RS01740	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D3869_RS01745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3869_RS01745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3869_RS01755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3869_RS01755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3869_RS01760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D3869_RS01765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3869_RS01770	COG0698	ribose 5-phosphate isomerase
D3869_RS01790	COG3685	Protein conserved in bacteria
D3869_RS01810	COG2153	protein acetylation
D3869_RS01820	COG1793	dna ligase
D3869_RS01830	COG2313	pseudouridylate synthase activity
D3869_RS01840	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D3869_RS01860	COG1217	gtp-binding protein TYPA
D3869_RS01895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_RS01905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_RS01915	COG1755	Isoprenylcysteine carboxyl methyltransferase
D3869_RS01920	COG3424	synthase
D3869_RS01930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D3869_RS01935	COG1492	cobalamin metabolic process
D3869_RS01995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D3869_RS02005	COG1024	Enoyl-CoA hydratase
D3869_RS02015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3869_RS02020	COG3411	Ferredoxin
D3869_RS02040	COG3546	catalase activity
D3869_RS02045	COG2807	transmembrane transport
D3869_RS02050	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D3869_RS02095	COG0546	phosphoglycolate phosphatase activity
D3869_RS02110	COG3108	Peptidase M15
D3869_RS02120	COG1773	rubredoxin
D3869_RS02135	COG1752	Esterase of the alpha-beta hydrolase superfamily
D3869_RS02140	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D3869_RS02190	COG2824	Alkylphosphonate utilization operon protein PhnA
D3869_RS02205	COG0243	molybdopterin cofactor binding
D3869_RS02215	COG3706	GGDEF domain
D3869_RS02240	COG0646	methionine synthase
D3869_RS02240	COG1410	methionine synthase
D3869_RS02260	COG2853	Lipoprotein
D3869_RS02275	COG0488	(ABC) transporter
D3869_RS02280	COG1671	Belongs to the UPF0178 family
D3869_RS02285	COG5002	protein histidine kinase activity
D3869_RS02285	COG2176	DNA-directed DNA polymerase activity
D3869_RS02310	COG1640	4-alpha-glucanotransferase
D3869_RS02330	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3869_RS02335	COG0366	Alpha amylase catalytic
D3869_RS02350	COG1218	3'(2'),5'-bisphosphate nucleotidase
D3869_RS02355	COG2833	Protein of unknown function (DUF455)
D3869_RS02370	COG1960	acyl-CoA dehydrogenase activity
D3869_RS02375	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS02380	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_RS02385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_RS02390	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3869_RS02440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_RS02450	COG1846	Transcriptional regulator
D3869_RS02455	COG2267	carboxylic ester hydrolase activity
D3869_RS02470	COG2226	methyltransferase
D3869_RS02475	COG1201	RNA secondary structure unwinding
D3869_RS02485	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D3869_RS02490	COG0415	Belongs to the DNA photolyase family
D3869_RS02500	COG0735	belongs to the Fur family
D3869_RS02505	COG0523	cobalamin synthesis protein
D3869_RS02525	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D3869_RS02530	COG1234	tRNA 3'-trailer cleavage
D3869_RS02540	COG0840	transmembrane signaling receptor activity
D3869_RS02545	COG0840	transmembrane signaling receptor activity
D3869_RS02555	COG0259	pyridoxamine-phosphate oxidase activity
D3869_RS02560	COG4520	surface antigen
D3869_RS02590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_RS02590	COG4191	Histidine kinase
D3869_RS02605	COG3437	response regulator, receiver
D3869_RS02605	COG0784	Response regulator, receiver
D3869_RS02625	COG2076	Multidrug Resistance protein
D3869_RS02630	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS02635	COG1765	OsmC-like protein
D3869_RS02645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D3869_RS02655	COG0697	spore germination
D3869_RS02665	COG0367	asparagine synthase
D3869_RS02680	COG0438	transferase activity, transferring glycosyl groups
D3869_RS02685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3869_RS02705	COG2885	chlorophyll binding
D3869_RS02720	COG0848	biopolymer transport protein
D3869_RS02730	COG0824	Thioesterase
D3869_RS02735	COG2255	four-way junction helicase activity
D3869_RS02750	COG0217	transcriptional regulatory protein
D3869_RS02755	COG1692	metallophosphoesterase
D3869_RS02760	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D3869_RS02805	COG1830	Aldolase
D3869_RS02810	COG0352	thiamine-phosphate diphosphorylase activity
D3869_RS02815	COG0730	response to heat
D3869_RS02820	COG2067	long-chain fatty acid transport protein
D3869_RS02825	COG0604	alcohol dehydrogenase
D3869_RS02830	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D3869_RS02835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D3869_RS02840	COG0483	inositol monophosphate 1-phosphatase activity
D3869_RS02860	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D3869_RS02865	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D3869_RS02870	COG0509	glycine decarboxylation via glycine cleavage system
D3869_RS02875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D3869_RS02895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D3869_RS02905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D3869_RS02910	COG0328	RNA-DNA hybrid ribonuclease activity
D3869_RS02915	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_RS02920	COG0678	peroxiredoxin activity
D3869_RS02930	COG1678	Uncharacterized ACR, COG1678
D3869_RS02940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3869_RS02945	COG0612	Peptidase, M16
D3869_RS02955	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D3869_RS02965	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D3869_RS02970	COG3346	SURF1 family
D3869_RS02990	COG0109	protoheme IX farnesyltransferase activity
D3869_RS02995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3869_RS03000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3869_RS03010	COG0312	modulator of DNA gyrase
D3869_RS03020	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3869_RS03030	COG5487	UPF0391 membrane protein
D3869_RS03040	COG0741	lytic transglycosylase activity
D3869_RS03070	COG0564	pseudouridine synthase activity
D3869_RS03090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D3869_RS03095	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D3869_RS03105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3869_RS03120	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D3869_RS03125	COG1295	ribonuclease BN
D3869_RS03130	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3869_RS03140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D3869_RS03150	COG0745	RESPONSE REGULATOR receiver
D3869_RS03160	COG0616	signal peptide processing
D3869_RS03175	COG0784	Response regulator, receiver
D3869_RS03175	COG5002	protein histidine kinase activity
D3869_RS03175	COG2198	Histidine kinase
D3869_RS03185	COG0390	transport system, permease component
D3869_RS03190	COG1116	anion transmembrane transporter activity
D3869_RS03200	COG0628	permease
D3869_RS03205	COG2205	protein histidine kinase activity
D3869_RS03215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3869_RS03225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3869_RS03230	COG0251	oxidation-reduction process
D3869_RS03240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3869_RS03240	COG0551	DNA topoisomerase type I activity
D3869_RS03275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3869_RS03285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3869_RS03320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3869_RS03335	COG0505	Belongs to the CarA family
D3869_RS03345	COG1403	HNH endonuclease
D3869_RS03355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3869_RS03360	COG1393	Belongs to the ArsC family
D3869_RS03365	COG2890	protein-(glutamine-N5) methyltransferase activity
D3869_RS03370	COG0456	acetyltransferase
D3869_RS03370	COG1214	PFAM Peptidase M22, glycoprotease
D3869_RS03410	COG0538	isocitrate dehydrogenase activity
D3869_RS03420	COG3932	Exopolysaccharide synthesis, ExoD
D3869_RS03440	COG0473	3-isopropylmalate dehydrogenase activity
D3869_RS03470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3869_RS03490	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3869_RS03505	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D3869_RS03530	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3869_RS03535	COG1684	flagellar biosynthetic protein fliR
D3869_RS03540	COG1987	bacterial-type flagellum assembly
D3869_RS03545	COG1677	Flagellar hook-basal body complex protein FliE
D3869_RS03550	COG1558	bacterial-type flagellum-dependent cell motility
D3869_RS03555	COG1815	bacterial-type flagellum-dependent cell motility
D3869_RS03560	COG2257	FlhB HrpN YscU SpaS Family
D3869_RS03575	COG1338	Plays a role in the flagellum-specific transport system
D3869_RS03590	COG1360	Flagellar Motor Protein
D3869_RS03630	COG4786	Flagellar basal body rod
D3869_RS03635	COG4786	Flagellar basal body rod
D3869_RS03645	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D3869_RS03685	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D3869_RS03710	COG0500	methyltransferase
D3869_RS03720	COG1132	(ABC) transporter
D3869_RS03725	COG0254	rRNA binding
D3869_RS03735	COG0071	Belongs to the small heat shock protein (HSP20) family
D3869_RS03755	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D3869_RS03770	COG2186	Transcriptional regulator
D3869_RS03775	COG0563	adenylate kinase activity
D3869_RS03780	COG0201	protein transport
D3869_RS03785	COG0200	Binds to the 23S rRNA
D3869_RS03790	COG1841	ribosomal large subunit assembly
D3869_RS03805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D3869_RS03810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D3869_RS03815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D3869_RS03825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D3869_RS03835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D3869_RS03840	COG0255	Belongs to the universal ribosomal protein uL29 family
D3869_RS03845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D3869_RS03850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D3869_RS03855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D3869_RS03860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D3869_RS03865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D3869_RS03870	COG0089	rRNA binding
D3869_RS03875	COG0088	Forms part of the polypeptide exit tunnel
D3869_RS03885	COG0051	transcription antitermination factor activity, RNA binding
D3869_RS03900	COG0049	tRNA binding
D3869_RS03915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D3869_RS03920	COG0085	RNA polymerase activity
D3869_RS03925	COG0222	ribosome binding
D3869_RS03930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D3869_RS03935	COG0081	regulation of translation
D3869_RS03940	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D3869_RS04040	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D3869_RS04050	COG1940	carbohydrate kinase activity
D3869_RS04060	COG2972	Histidine kinase
D3869_RS04060	COG0840	transmembrane signaling receptor activity
D3869_RS04070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3869_RS04080	COG0411	ABC transporter
D3869_RS04110	COG0673	inositol 2-dehydrogenase activity
D3869_RS04120	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3869_RS04130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_RS04135	COG1309	transcriptional regulator
D3869_RS04145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3869_RS04165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3869_RS04205	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3869_RS04210	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3869_RS04215	COG1530	ribonuclease E activity
D3869_RS04245	COG0436	Aminotransferase
D3869_RS04255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D3869_RS04270	COG2264	protein methyltransferase activity
D3869_RS04280	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D3869_RS04295	COG0312	modulator of DNA gyrase
D3869_RS04315	COG1597	lipid kinase activity
D3869_RS04335	COG1519	Transferase
D3869_RS04340	COG1663	tetraacyldisaccharide 4'-kinase activity
D3869_RS04350	COG1280	lysine exporter protein (LysE YggA)
D3869_RS04380	COG3719	Belongs to the RNase T2 family
D3869_RS04385	COG0439	Biotin carboxylase
D3869_RS04390	COG0511	ligase activity, forming carbon-carbon bonds
D3869_RS04425	COG0840	transmembrane signaling receptor activity
D3869_RS04445	COG3108	Peptidase M15
D3869_RS04450	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3869_RS04450	COG3409	Peptidoglycan-binding domain 1 protein
D3869_RS04480	COG2205	protein histidine kinase activity
D3869_RS04490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3869_RS04525	COG1073	alpha beta
D3869_RS04530	COG1380	Effector of murein hydrolase LrgA
D3869_RS04535	COG1346	cytolysis
D3869_RS04540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3869_RS04550	COG0751	glycine-tRNA ligase activity
D3869_RS04555	COG0752	glycyl-tRNA synthetase alpha subunit
D3869_RS04575	COG2890	protein-(glutamine-N5) methyltransferase activity
D3869_RS04585	COG0142	geranyltranstransferase activity
D3869_RS04610	COG4191	Histidine kinase
D3869_RS04610	COG0784	Response regulator, receiver
D3869_RS04620	COG2084	Dehydrogenase
D3869_RS04625	COG0277	FAD linked oxidase domain protein
D3869_RS04640	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D3869_RS04645	COG0488	(ABC) transporter
D3869_RS04650	COG0697	spore germination
D3869_RS04665	COG2001	Belongs to the MraZ family
D3869_RS04685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D3869_RS04695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3869_RS04710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D3869_RS04720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D3869_RS04725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D3869_RS04730	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3869_RS04735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D3869_RS04740	COG0849	cell division
D3869_RS04745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D3869_RS04760	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D3869_RS04785	COG0497	DNA recombination
D3869_RS04790	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3869_RS04805	COG0745	RESPONSE REGULATOR receiver
D3869_RS04810	COG0006	proline dipeptidase activity
D3869_RS04810	COG0006	proline dipeptidase activity
D3869_RS04820	COG2264	protein methyltransferase activity
D3869_RS04835	COG0210	DNA helicase
D3869_RS04840	COG2197	response regulator
D3869_RS04845	COG2197	response regulator
D3869_RS04875	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D3869_RS04885	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3869_RS04895	COG2205	protein histidine kinase activity
D3869_RS04905	COG2205	protein histidine kinase activity
D3869_RS04905	COG2202	Pas domain
D3869_RS04945	COG2988	succinylglutamate desuccinylase activity
D3869_RS04950	COG3180	Ammonia monooxygenase
D3869_RS04960	COG0628	permease
D3869_RS04965	COG0330	HflC and HflK could
D3869_RS04990	COG0745	RESPONSE REGULATOR receiver
D3869_RS05010	COG1116	anion transmembrane transporter activity
D3869_RS05015	COG1643	Atp-dependent helicase
D3869_RS05030	COG2719	SpoVR family
D3869_RS05035	COG2718	Belongs to the UPF0229 family
D3869_RS05040	COG2766	serine protein kinase
D3869_RS05050	COG0745	RESPONSE REGULATOR receiver
D3869_RS05060	COG0784	Response regulator, receiver
D3869_RS05060	COG2205	protein histidine kinase activity
D3869_RS05065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3869_RS05080	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D3869_RS05120	COG1116	anion transmembrane transporter activity
D3869_RS05170	COG1131	(ABC) transporter
D3869_RS05185	COG0723	plastoquinol--plastocyanin reductase activity
D3869_RS05200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3869_RS05210	COG0463	Glycosyl transferase, family 2
D3869_RS05240	COG0602	queuosine metabolic process
D3869_RS05245	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D3869_RS05285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D3869_RS05290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D3869_RS05295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D3869_RS05305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3869_RS05315	COG2010	Cytochrome c
D3869_RS05325	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D3869_RS05330	COG0799	negative regulation of ribosome biogenesis
D3869_RS05335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D3869_RS05340	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D3869_RS05350	COG0793	Belongs to the peptidase S41A family
D3869_RS05360	COG1051	belongs to the nudix hydrolase family
D3869_RS05380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D3869_RS05390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3869_RS05410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3869_RS05420	COG4974	Belongs to the 'phage' integrase family
D3869_RS05425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3869_RS05435	COG0596	Alpha beta hydrolase
D3869_RS05455	COG4191	Histidine kinase
D3869_RS05465	COG4106	trans-aconitate 2-methyltransferase activity
D3869_RS05495	COG2226	methyltransferase
D3869_RS05500	COG0126	phosphoglycerate kinase activity
D3869_RS05510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D3869_RS05525	COG3474	cytochrome
D3869_RS05530	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D3869_RS05560	COG4166	transmembrane transport
D3869_RS05570	COG4166	transmembrane transport
D3869_RS05575	COG4174	ABC transporter (Permease)
D3869_RS05580	COG4239	(ABC) transporter, permease
D3869_RS05585	COG4172	Belongs to the ABC transporter superfamily
D3869_RS05605	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3869_RS05610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3869_RS05615	COG0625	glutathione transferase activity
D3869_RS05620	COG2358	TRAP transporter, solute receptor (TAXI family
D3869_RS05640	COG0587	DNA-directed DNA polymerase activity
D3869_RS05675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3869_RS05680	COG0625	glutathione transferase activity
D3869_RS05690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_RS05695	COG0601	transmembrane transport
D3869_RS05705	COG1024	Enoyl-CoA hydratase
D3869_RS05720	COG0583	DNA-binding transcription factor activity
D3869_RS05745	COG5001	Diguanylate cyclase
D3869_RS05750	COG0625	glutathione transferase activity
D3869_RS05755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3869_RS05765	COG0156	8-amino-7-oxononanoate synthase activity
D3869_RS05785	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS05800	COG1322	Protein conserved in bacteria
D3869_RS05805	COG1278	Cold shock
D3869_RS05815	COG0242	peptide deformylase activity
D3869_RS05820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D3869_RS05825	COG0101	tRNA pseudouridine synthase activity
D3869_RS05845	COG2378	regulation of single-species biofilm formation
D3869_RS05850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3869_RS05865	COG0335	large ribosomal subunit rRNA binding
D3869_RS05875	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D3869_RS05880	COG0228	four-way junction DNA binding
D3869_RS05885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D3869_RS05925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3869_RS05945	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D3869_RS05960	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3869_RS05970	COG1131	(ABC) transporter
D3869_RS05980	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D3869_RS05985	COG0697	spore germination
D3869_RS06005	COG0489	protein tyrosine kinase activity
D3869_RS06005	COG3206	protein involved in exopolysaccharide biosynthesis
D3869_RS06015	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D3869_RS06025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3869_RS06040	COG0438	transferase activity, transferring glycosyl groups
D3869_RS06070	COG1215	transferase activity, transferring glycosyl groups
D3869_RS06080	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D3869_RS06090	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D3869_RS06095	COG0706	membrane insertase activity
D3869_RS06100	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D3869_RS06115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3869_RS06125	COG0598	Magnesium transport protein CorA
D3869_RS06140	COG0825	malonyl-CoA metabolic process
D3869_RS06155	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D3869_RS06160	COG4974	Belongs to the 'phage' integrase family
D3869_RS06180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D3869_RS06185	COG0517	IMP dehydrogenase activity
D3869_RS06200	COG0271	Belongs to the BolA IbaG family
D3869_RS06230	COG1840	ABC-type Fe3 transport system, periplasmic component
D3869_RS06235	COG1741	Belongs to the pirin family
D3869_RS06240	COG1178	ABC-type Fe3 transport system permease component
D3869_RS06245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3869_RS06255	COG0135	phosphoribosylanthranilate isomerase activity
D3869_RS06280	COG2423	ornithine cyclodeaminase activity
D3869_RS06290	COG0776	regulation of translation
D3869_RS06300	COG0539	negative regulation of cytoplasmic translation
D3869_RS06315	COG0405	Gamma-glutamyltransferase
D3869_RS06335	COG1741	Belongs to the pirin family
D3869_RS06340	COG0303	'Molybdopterin
D3869_RS06345	COG0303	'Molybdopterin
D3869_RS06365	COG0463	Glycosyl transferase, family 2
D3869_RS06375	COG0071	Belongs to the small heat shock protein (HSP20) family
D3869_RS06405	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D3869_RS06435	COG1215	transferase activity, transferring glycosyl groups
D3869_RS06455	COG1012	belongs to the aldehyde dehydrogenase family
D3869_RS06490	COG3162	membrane
D3869_RS06505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3869_RS06510	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D3869_RS06515	COG1040	competence protein
D3869_RS06520	COG1987	bacterial-type flagellum assembly
D3869_RS06525	COG4106	trans-aconitate 2-methyltransferase activity
D3869_RS06545	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D3869_RS06550	COG0513	Belongs to the DEAD box helicase family
D3869_RS06555	COG1970	mechanosensitive ion channel activity
D3869_RS06560	COG0653	protein targeting
D3869_RS06565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3869_RS06575	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D3869_RS06585	COG0494	nUDIX hydrolase
D3869_RS06590	COG0514	ATP-dependent DNA helicase (RecQ)
D3869_RS06615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_RS06615	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3869_RS06620	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3869_RS06625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_RS06655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3869_RS06665	COG0412	Dienelactone hydrolase
D3869_RS06670	COG0033	Phosphoglucomutase
D3869_RS06675	COG1278	Cold shock
D3869_RS06705	COG0302	gtp cyclohydrolase
D3869_RS06710	COG2202	Pas domain
D3869_RS06710	COG2205	protein histidine kinase activity
D3869_RS06740	COG0285	dihydrofolate synthase activity
D3869_RS06745	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D3869_RS06755	COG0133	tryptophan synthase activity
D3869_RS06760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_RS06765	COG5002	protein histidine kinase activity
D3869_RS06765	COG2205	protein histidine kinase activity
D3869_RS06765	COG0784	Response regulator, receiver
D3869_RS06770	COG2205	protein histidine kinase activity
D3869_RS06775	COG1252	NADH dehydrogenase
D3869_RS06810	COG0802	atpase or kinase
D3869_RS06820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D3869_RS06825	COG2887	Belongs to the helicase family. UvrD subfamily
D3869_RS06830	COG1074	ATP-dependent DNA helicase activity
D3869_RS06840	COG0583	DNA-binding transcription factor activity
D3869_RS06850	COG3001	Fructosamine kinase
D3869_RS06855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3869_RS06860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D3869_RS06865	COG1573	uracil-dna glycosylase
D3869_RS06875	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3869_RS06885	COG0598	Magnesium transport protein CorA
D3869_RS06890	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D3869_RS06895	COG1872	DUF167
D3869_RS06910	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3869_RS06915	COG4133	protoheme IX ABC transporter activity
D3869_RS06920	COG2985	domain, Protein
D3869_RS06925	COG2985	domain, Protein
D3869_RS06975	COG0671	phosphoesterase, PA-phosphatase related
D3869_RS06985	COG3437	response regulator, receiver
D3869_RS06985	COG0784	Response regulator, receiver
D3869_RS07000	COG1983	PspC domain protein
D3869_RS07010	COG1842	Phage shock protein A
D3869_RS07015	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D3869_RS07025	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3869_RS07040	COG3005	denitrification pathway
D3869_RS07045	COG1858	cytochrome C peroxidase
D3869_RS07050	COG0753	catalase activity
D3869_RS07055	COG0459	protein refolding
D3869_RS07060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D3869_RS07065	COG5425	PFAM Usg family protein
D3869_RS07070	COG3772	lysozyme
D3869_RS07075	COG0493	'glutamate synthase
D3869_RS07075	COG0543	2 iron, 2 sulfur cluster binding
D3869_RS07080	COG1612	heme a metabolic process
D3869_RS07105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_RS07115	COG0668	transmembrane transport
D3869_RS07125	COG4181	ATPase activity
D3869_RS07140	COG0667	Aldo Keto reductase
D3869_RS07145	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D3869_RS07150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3869_RS07155	COG0347	Belongs to the P(II) protein family
D3869_RS07160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3869_RS07180	COG0606	chelatase, subunit chli
D3869_RS07190	COG0747	negative chemotaxis
D3869_RS07205	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D3869_RS07225	COG3685	Protein conserved in bacteria
D3869_RS07240	COG2304	oxidoreductase activity
D3869_RS07250	COG1013	pyruvate-flavodoxin oxidoreductase activity
D3869_RS07255	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D3869_RS07255	COG0674	pyruvate-flavodoxin oxidoreductase activity
D3869_RS07260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D3869_RS07265	COG2205	protein histidine kinase activity
D3869_RS07265	COG2202	Pas domain
D3869_RS07270	COG0693	protein deglycase activity
D3869_RS07275	COG2224	Isocitrate lyase
D3869_RS07280	COG3800	Transcriptional regulator
D3869_RS07280	COG1396	sequence-specific DNA binding
D3869_RS07295	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3869_RS07300	COG3437	response regulator, receiver
D3869_RS07300	COG0784	Response regulator, receiver
D3869_RS07305	COG3706	GGDEF domain
D3869_RS07310	COG0484	heat shock protein binding
D3869_RS07315	COG0443	Heat shock 70 kDa protein
D3869_RS07345	COG1420	regulation of RNA biosynthetic process
D3869_RS07350	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D3869_RS07355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D3869_RS07360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3869_RS07395	COG0792	nuclease activity
D3869_RS07400	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D3869_RS07420	COG1366	Belongs to the anti-sigma-factor antagonist family
D3869_RS07430	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D3869_RS07470	COG0784	Response regulator, receiver
D3869_RS07470	COG2205	protein histidine kinase activity
D3869_RS07480	COG0180	Tryptophanyl-tRNA synthetase
D3869_RS07490	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D3869_RS07500	COG3012	SEC-C Motif Domain Protein
D3869_RS07515	COG0110	maltose O-acetyltransferase activity
D3869_RS07520	COG1309	transcriptional regulator
D3869_RS07525	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS07540	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D3869_RS07545	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D3869_RS07550	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3869_RS07575	COG0438	transferase activity, transferring glycosyl groups
D3869_RS07595	COG1132	(ABC) transporter
D3869_RS07600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_RS07600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3869_RS07630	COG0601	transmembrane transport
D3869_RS07635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_RS07645	COG1234	tRNA 3'-trailer cleavage
D3869_RS07665	COG0745	RESPONSE REGULATOR receiver
D3869_RS07745	COG0357	Ribosomal RNA small subunit methyltransferase G
D3869_RS07750	COG0445	tRNA wobble uridine modification
D3869_RS07760	COG3411	Ferredoxin
D3869_RS07770	COG1331	Highly conserved protein containing a thioredoxin domain
D3869_RS07785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3869_RS07790	COG0237	dephospho-CoA kinase activity
D3869_RS07815	COG1981	membrane
D3869_RS07825	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D3869_RS07830	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D3869_RS07840	COG4395	Tim44
D3869_RS07845	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D3869_RS07900	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D3869_RS07910	COG0488	(ABC) transporter
D3869_RS07915	COG2205	protein histidine kinase activity
D3869_RS07930	COG1556	Lactate utilization protein
D3869_RS07935	COG1139	Iron-sulfur cluster binding protein
D3869_RS07940	COG0247	lactate metabolic process
D3869_RS07960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3869_RS07965	COG1121	(ABC) transporter
D3869_RS07975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D3869_RS07980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3869_RS07990	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3869_RS08005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3869_RS08010	COG0730	response to heat
D3869_RS08035	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D3869_RS08045	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D3869_RS08050	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D3869_RS08080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3869_RS08090	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D3869_RS08095	COG1253	flavin adenine dinucleotide binding
D3869_RS08100	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D3869_RS08105	COG1396	sequence-specific DNA binding
D3869_RS08110	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D3869_RS08115	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D3869_RS08120	COG2329	Antibiotic biosynthesis monooxygenase
D3869_RS08125	COG0779	Required for maturation of 30S ribosomal subunits
D3869_RS08150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D3869_RS08160	COG1185	polyribonucleotide nucleotidyltransferase activity
D3869_RS08165	COG2321	neutral zinc metallopeptidase
D3869_RS08175	COG1509	lysine 2,3-aminomutase activity
D3869_RS08180	COG0584	glycerophosphoryl diester phosphodiesterase
D3869_RS08195	COG1592	Rubrerythrin
D3869_RS08225	COG0039	L-malate dehydrogenase activity
D3869_RS08230	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D3869_RS08235	COG4166	transmembrane transport
D3869_RS08245	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3869_RS08250	COG2226	methyltransferase
D3869_RS08255	COG0457	Tetratricopeptide repeat
D3869_RS08255	COG0859	PFAM glycosyl transferase family 9
D3869_RS08260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D3869_RS08270	COG1024	Enoyl-CoA hydratase
D3869_RS08275	COG0268	Binds directly to 16S ribosomal RNA
D3869_RS08280	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D3869_RS08290	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3869_RS08295	COG3842	ATPase activity
D3869_RS08315	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_RS08320	COG1177	transmembrane transport
D3869_RS08335	COG2132	Multicopper oxidase
D3869_RS08345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D3869_RS08385	COG2217	Heavy metal translocating P-type atpase
D3869_RS08395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_RS08400	COG0281	malic enzyme
D3869_RS08400	COG0280	phosphate acetyltransferase
D3869_RS08405	COG5002	protein histidine kinase activity
D3869_RS08410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D3869_RS08415	COG0573	inorganic phosphate transmembrane transporter activity
D3869_RS08425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D3869_RS08435	COG0745	RESPONSE REGULATOR receiver
D3869_RS08450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D3869_RS08460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3869_RS08470	COG0756	dUTP diphosphatase activity
D3869_RS08475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D3869_RS08480	COG2204	response regulator
D3869_RS08485	COG1278	Cold shock
D3869_RS08495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3869_RS08500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3869_RS08500	COG1321	iron dependent repressor
D3869_RS08505	COG1121	(ABC) transporter
D3869_RS08510	COG0803	Belongs to the bacterial solute-binding protein 9 family
D3869_RS08545	COG2202	Pas domain
D3869_RS08545	COG2205	protein histidine kinase activity
D3869_RS08565	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D3869_RS08570	COG1253	flavin adenine dinucleotide binding
D3869_RS08585	COG0477	Major facilitator Superfamily
D3869_RS08590	COG0583	DNA-binding transcription factor activity
D3869_RS08595	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D3869_RS08620	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3869_RS08640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D3869_RS08645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D3869_RS08650	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D3869_RS08665	COG0784	Response regulator, receiver
D3869_RS08665	COG3437	response regulator, receiver
D3869_RS08675	COG0583	DNA-binding transcription factor activity
D3869_RS08685	COG0481	GTPase activity
D3869_RS08695	COG0297	glycogen (starch) synthase activity
D3869_RS08700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3869_RS08705	COG0004	ammonium transporteR
D3869_RS08740	COG3806	Anti-sigma factor
D3869_RS08745	COG1595	DNA-templated transcription, initiation
D3869_RS08755	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D3869_RS08770	COG0137	argininosuccinate synthase activity
D3869_RS08785	COG2897	thiosulfate sulfurtransferase activity
D3869_RS08790	COG3339	Conserved Protein
D3869_RS08795	COG0697	spore germination
D3869_RS08800	COG4235	cytochrome complex assembly
D3869_RS08805	COG3088	subunit of a heme lyase
D3869_RS08810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3869_RS08815	COG1138	Cytochrome C-type biogenesis protein
D3869_RS08820	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D3869_RS08830	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3869_RS08865	COG0747	negative chemotaxis
D3869_RS08870	COG0601	transmembrane transport
D3869_RS08875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_RS08900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D3869_RS08910	COG0302	gtp cyclohydrolase
D3869_RS08915	COG2967	ApaG domain
D3869_RS09000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_RS09015	COG5002	protein histidine kinase activity
D3869_RS09030	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3869_RS09035	COG4191	Histidine kinase
D3869_RS09035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_RS09045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3869_RS09055	COG2885	chlorophyll binding
D3869_RS09085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3869_RS09115	COG0181	hydroxymethylbilane synthase activity
D3869_RS09120	COG2264	protein methyltransferase activity
D3869_RS09135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D3869_RS09140	COG2350	Protein conserved in bacteria
D3869_RS09155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3869_RS09175	COG0501	Belongs to the peptidase M48B family
D3869_RS09190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3869_RS09190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D3869_RS09200	COG0138	bifunctional purine biosynthesis protein purh
D3869_RS09225	COG2264	protein methyltransferase activity
D3869_RS09235	COG2902	Dehydrogenase
D3869_RS09240	COG3437	response regulator, receiver
D3869_RS09240	COG2770	Histidine kinase
D3869_RS09260	COG0679	Auxin Efflux Carrier
D3869_RS09265	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3869_RS09280	COG3118	belongs to the thioredoxin family
D3869_RS09285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3869_RS09290	COG2835	tetraacyldisaccharide 4'-kinase activity
D3869_RS09325	COG1285	pathogenesis
D3869_RS09330	COG2814	Major facilitator Superfamily
D3869_RS09365	COG0395	ABC-type sugar transport system, permease component
D3869_RS09370	COG3842	ATPase activity
D3869_RS09375	COG0625	glutathione transferase activity
D3869_RS09390	COG0513	Belongs to the DEAD box helicase family
D3869_RS09430	COG0745	RESPONSE REGULATOR receiver
D3869_RS09450	COG0745	RESPONSE REGULATOR receiver
D3869_RS09465	COG1366	Belongs to the anti-sigma-factor antagonist family
D3869_RS09470	COG0840	transmembrane signaling receptor activity
D3869_RS09475	COG2201	protein-glutamate methylesterase activity
D3869_RS09480	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D3869_RS09490	COG0840	transmembrane signaling receptor activity
D3869_RS09495	COG0835	chemotaxis
D3869_RS09500	COG2198	Histidine kinase
D3869_RS09500	COG0643	Histidine kinase
D3869_RS09505	COG0745	RESPONSE REGULATOR receiver
D3869_RS09515	COG5002	protein histidine kinase activity
D3869_RS09525	COG2176	DNA-directed DNA polymerase activity
D3869_RS09525	COG5002	protein histidine kinase activity
D3869_RS09530	COG0745	RESPONSE REGULATOR receiver
D3869_RS09555	COG2917	probably involved in intracellular septation
D3869_RS09565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D3869_RS09570	COG0552	protein localization to endoplasmic reticulum
D3869_RS09575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3869_RS09580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D3869_RS09630	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D3869_RS09645	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D3869_RS09650	COG3706	GGDEF domain
D3869_RS09655	COG2205	protein histidine kinase activity
D3869_RS09660	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3869_RS09675	COG0045	succinate-CoA ligase (ADP-forming) activity
D3869_RS09680	COG0039	L-malate dehydrogenase activity
D3869_RS09695	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D3869_RS09700	COG2076	Multidrug Resistance protein
D3869_RS09710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3869_RS09715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3869_RS09715	COG1199	ATP-dependent helicase activity
D3869_RS09730	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D3869_RS09735	COG0840	transmembrane signaling receptor activity
D3869_RS09735	COG2972	Histidine kinase
D3869_RS09750	COG2084	Dehydrogenase
D3869_RS09760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3869_RS09795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3869_RS09910	COG0167	dihydroorotate dehydrogenase activity
D3869_RS09920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D3869_RS09925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3869_RS09930	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3869_RS10020	COG4695	Portal protein
D3869_RS10070	COG0582	viral genome integration into host DNA
D3869_RS10075	COG1902	pentaerythritol trinitrate reductase activity
D3869_RS10120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3869_RS10125	COG1116	anion transmembrane transporter activity
D3869_RS10130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_RS10135	COG0583	DNA-binding transcription factor activity
D3869_RS10180	COG1846	Transcriptional regulator
D3869_RS10190	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D3869_RS10235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3869_RS10240	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3869_RS10250	COG0783	Belongs to the Dps family
D3869_RS10260	COG0492	ferredoxin-NADP+ reductase activity
D3869_RS10275	COG3660	Nucleoside-diphosphate-sugar epimerase
D3869_RS10280	COG1522	sequence-specific DNA binding
D3869_RS10290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3869_RS10295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D3869_RS10320	COG1674	ftsk spoiiie
D3869_RS10330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3869_RS10340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3869_RS10345	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS10350	COG1238	metal cluster binding
D3869_RS10370	COG1012	belongs to the aldehyde dehydrogenase family
D3869_RS10395	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D3869_RS10410	COG2205	protein histidine kinase activity
D3869_RS10410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_RS10430	COG5002	protein histidine kinase activity
D3869_RS10440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3869_RS10450	COG3279	Response regulator of the LytR AlgR family
D3869_RS10465	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D3869_RS10480	COG1902	pentaerythritol trinitrate reductase activity
D3869_RS10490	COG2962	Rard protein
D3869_RS10500	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D3869_RS10510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3869_RS10515	COG0047	phosphoribosylformylglycinamidine synthase activity
D3869_RS10520	COG0583	DNA-binding transcription factor activity
D3869_RS10530	COG2258	MOSC domain
D3869_RS10540	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3869_RS10545	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3869_RS10560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D3869_RS10580	COG0024	Methionine aminopeptidase
D3869_RS10585	COG1489	DNA binding
D3869_RS10590	COG1546	Belongs to the CinA family
D3869_RS10590	COG1058	Belongs to the CinA family
D3869_RS10635	COG0124	histidyl-tRNA synthetase
D3869_RS10640	COG0418	dihydroorotase activity
D3869_RS10650	COG1570	exodeoxyribonuclease VII activity
D3869_RS10670	COG4783	chaperone-mediated protein folding
D3869_RS10675	COG0590	tRNA wobble adenosine to inosine editing
D3869_RS10680	COG3360	Dodecin
D3869_RS10685	COG1187	pseudouridine synthase activity
D3869_RS10690	COG0742	ribosomal rna small subunit methyltransferase
D3869_RS10705	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3869_RS10770	COG1749	Flagellar hook protein flgE
D3869_RS10775	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D3869_RS10785	COG0667	Aldo Keto reductase
D3869_RS10795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_RS10800	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D3869_RS10805	COG1301	dicarboxylic acid transport
D3869_RS10810	COG2828	Protein conserved in bacteria
D3869_RS10815	COG0583	DNA-binding transcription factor activity
D3869_RS10825	COG2188	Transcriptional regulator
D3869_RS10830	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3869_RS10855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3869_RS10875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3869_RS10885	COG1116	anion transmembrane transporter activity
D3869_RS10965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D3869_RS10980	COG0166	Belongs to the GPI family
D3869_RS10985	COG0612	Peptidase, M16
D3869_RS10990	COG0612	Peptidase, M16
D3869_RS11000	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D3869_RS11005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D3869_RS11010	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3869_RS11015	COG0196	riboflavin kinase activity
D3869_RS11020	COG2030	dehydratase
D3869_RS11030	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D3869_RS11055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3869_RS11060	COG2703	oxygen carrier activity
D3869_RS11085	COG0590	tRNA wobble adenosine to inosine editing
D3869_RS11095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_RS11110	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D3869_RS11135	COG1686	Belongs to the peptidase S11 family
D3869_RS11150	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3869_RS11155	COG0746	molybdenum cofactor guanylyltransferase activity
D3869_RS11180	COG3383	formate dehydrogenase (NAD+) activity
D3869_RS11180	COG0243	molybdopterin cofactor binding
D3869_RS11185	COG0437	4 iron, 4 sulfur cluster binding
D3869_RS11210	COG0235	Class ii aldolase
D3869_RS11220	COG3384	dioxygenase
D3869_RS11230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3869_RS11235	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3869_RS11240	COG0356	it plays a direct role in the translocation of protons across the membrane
D3869_RS11250	COG1999	signal sequence binding
D3869_RS11265	COG1702	phosphate starvation-inducible protein PhoH
D3869_RS11270	COG0850	regulation of cytokinetic process
D3869_RS11275	COG2894	cell division
D3869_RS11280	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D3869_RS11300	COG0840	transmembrane signaling receptor activity
D3869_RS11305	COG4948	Mandelate Racemase Muconate Lactonizing
D3869_RS11315	COG1104	cysteine desulfurase activity
D3869_RS11325	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3869_RS11340	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D3869_RS11360	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D3869_RS11365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3869_RS11370	COG1278	Cold shock
D3869_RS11380	COG0784	Response regulator, receiver
D3869_RS11380	COG2205	protein histidine kinase activity
D3869_RS11380	COG5002	protein histidine kinase activity
D3869_RS11400	COG0644	oxidoreductase
D3869_RS11405	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D3869_RS11465	COG5420	small protein containing a coiled-coil domain
D3869_RS11480	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D3869_RS11485	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D3869_RS11500	COG1959	2 iron, 2 sulfur cluster binding
D3869_RS11540	COG0121	glutamine amidotransferase
D3869_RS11555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3869_RS11580	COG5554	nitrogen fixation
D3869_RS11595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3869_RS11620	COG1309	transcriptional regulator
D3869_RS11630	COG1131	(ABC) transporter
D3869_RS11635	COG0842	Transport permease protein
D3869_RS11640	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D3869_RS11650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D3869_RS11660	COG0277	FAD linked oxidase domain protein
D3869_RS11665	COG0277	FAD linked oxidase domain protein
D3869_RS11670	COG0247	lactate metabolic process
D3869_RS11690	COG1960	acyl-CoA dehydrogenase activity
D3869_RS11705	COG0277	FAD linked oxidase domain protein
D3869_RS11710	COG0009	L-threonylcarbamoyladenylate synthase
D3869_RS11715	COG1192	Involved in chromosome partitioning
D3869_RS11720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3869_RS11725	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D3869_RS11745	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D3869_RS11750	COG2945	thiolester hydrolase activity
D3869_RS11755	COG1045	serine acetyltransferase
D3869_RS11770	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D3869_RS11775	COG0633	Ferredoxin
D3869_RS11780	COG0482	sulfurtransferase activity
D3869_RS11790	COG0583	DNA-binding transcription factor activity
D3869_RS11805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3869_RS11830	COG4221	oxidoreductase activity
D3869_RS11845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3869_RS11845	COG2010	Cytochrome c
D3869_RS11850	COG2080	2 iron, 2 sulfur cluster binding
D3869_RS11855	COG2010	Cytochrome c
D3869_RS11855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3869_RS11860	COG5002	protein histidine kinase activity
D3869_RS11870	COG0745	RESPONSE REGULATOR receiver
D3869_RS11895	COG0432	Pfam Uncharacterised protein family UPF0047
D3869_RS11905	COG2951	lytic endotransglycosylase activity
D3869_RS11925	COG1454	alcohol dehydrogenase
D3869_RS11960	COG0456	acetyltransferase
D3869_RS11975	COG0114	fumarate hydratase activity
D3869_RS11990	COG5001	Diguanylate cyclase
D3869_RS11995	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D3869_RS12010	COG0205	6-phosphofructokinase activity
D3869_RS12040	COG0288	reversible hydration of carbon dioxide
D3869_RS12055	COG0604	alcohol dehydrogenase
D3869_RS12055	COG3321	synthase
D3869_RS12055	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS12100	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_RS12110	COG0840	transmembrane signaling receptor activity
D3869_RS12130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D3869_RS12135	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D3869_RS12140	COG0343	queuine tRNA-ribosyltransferase activity
D3869_RS12145	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D3869_RS12150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3869_RS12190	COG2897	thiosulfate sulfurtransferase activity
D3869_RS12275	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D3869_RS12280	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3869_RS12285	COG0242	peptide deformylase activity
D3869_RS12295	COG3070	regulator of competence-specific genes
D3869_RS12310	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D3869_RS12335	COG4120	Belongs to the binding-protein-dependent transport system permease family
D3869_RS12350	COG0489	protein tyrosine kinase activity
D3869_RS12355	COG0330	HflC and HflK could
D3869_RS12360	COG0330	HflC and HflK could
D3869_RS12385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D3869_RS12390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3869_RS12395	COG0028	Belongs to the TPP enzyme family
D3869_RS12410	COG0704	Plays a role in the regulation of phosphate uptake
D3869_RS12415	COG2862	Uncharacterized protein family, UPF0114
D3869_RS12435	COG0768	penicillin binding
D3869_RS12455	COG1744	ABC transporter substrate-binding protein PnrA-like
D3869_RS12460	COG3845	ABC transporter
D3869_RS12465	COG4603	Belongs to the binding-protein-dependent transport system permease family
D3869_RS12470	COG1079	Belongs to the binding-protein-dependent transport system permease family
D3869_RS12475	COG0295	cytidine deaminase activity
D3869_RS12480	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D3869_RS12485	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D3869_RS12500	COG0697	spore germination
D3869_RS12520	COG0411	ABC transporter
D3869_RS12535	COG0038	chloride channel
D3869_RS12555	COG2326	polyphosphate kinase activity
D3869_RS12560	COG0366	Alpha amylase catalytic
D3869_RS12570	COG2199	diguanylate cyclase activity
D3869_RS12570	COG2200	EAL domain
D3869_RS12570	COG2203	Gaf domain
D3869_RS12580	COG2135	peptidase activity
D3869_RS12590	COG0784	Response regulator, receiver
D3869_RS12595	COG2261	transglycosylase associated protein
D3869_RS12600	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3869_RS12615	COG1733	regulation of RNA biosynthetic process
D3869_RS12630	COG2084	Dehydrogenase
D3869_RS12635	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS12650	COG0546	phosphoglycolate phosphatase activity
D3869_RS12665	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3869_RS12675	COG2832	Protein of unknown function (DUF454)
D3869_RS12680	COG1238	metal cluster binding
D3869_RS12690	COG0469	pyruvate kinase activity
D3869_RS12695	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D3869_RS12710	COG0203	ribosomal protein L17
D3869_RS12715	COG1238	metal cluster binding
D3869_RS12730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D3869_RS12745	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D3869_RS12750	COG0564	pseudouridine synthase activity
D3869_RS12755	COG1802	Transcriptional regulator
D3869_RS12760	COG3135	benzoate transporter
D3869_RS12765	COG0546	phosphoglycolate phosphatase activity
D3869_RS12790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3869_RS12795	COG3845	ABC transporter
D3869_RS12800	COG4603	Belongs to the binding-protein-dependent transport system permease family
D3869_RS12805	COG1079	Belongs to the binding-protein-dependent transport system permease family
D3869_RS12840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3869_RS12845	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3869_RS12860	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS12865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3869_RS12870	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D3869_RS12880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D3869_RS12885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3869_RS12890	COG0352	thiamine-phosphate diphosphorylase activity
D3869_RS12890	COG0351	phosphomethylpyrimidine kinase
D3869_RS12895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3869_RS12910	COG0670	Belongs to the BI1 family
D3869_RS12930	COG2030	dehydratase
D3869_RS12930	COG1012	belongs to the aldehyde dehydrogenase family
D3869_RS12935	COG0443	Heat shock 70 kDa protein
D3869_RS12960	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D3869_RS12960	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D3869_RS13010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3869_RS13015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3869_RS13025	COG0649	NAD binding
D3869_RS13030	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D3869_RS13040	COG1034	ATP synthesis coupled electron transport
D3869_RS13045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D3869_RS13050	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3869_RS13060	COG0713	ATP synthesis coupled electron transport
D3869_RS13075	COG1007	ATP synthesis coupled electron transport
D3869_RS13095	COG0346	lactoylglutathione lyase activity
D3869_RS13105	COG0519	Catalyzes the synthesis of GMP from XMP
D3869_RS13120	COG0442	prolyl-tRNA aminoacylation
D3869_RS13160	COG5634	Uncharacterized conserved protein (DUF2278)
D3869_RS13165	COG0052	Belongs to the universal ribosomal protein uS2 family
D3869_RS13170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D3869_RS13175	COG0528	UMP kinase activity
D3869_RS13180	COG0233	cytoplasmic translational termination
D3869_RS13185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D3869_RS13195	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D3869_RS13200	COG0750	zinc metalloprotease
D3869_RS13220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3869_RS13225	COG3494	Protein of unknown function (DUF1009)
D3869_RS13230	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3869_RS13245	COG0583	DNA-binding transcription factor activity
D3869_RS13260	COG0372	Belongs to the citrate synthase family
D3869_RS13265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3869_RS13270	COG2333	competence protein COMEC
D3869_RS13270	COG0658	competence protein
D3869_RS13275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D3869_RS13280	COG0303	'Molybdopterin
D3869_RS13285	COG0315	cyclic pyranopterin monophosphate synthase activity
D3869_RS13330	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3869_RS13340	COG0149	triose-phosphate isomerase activity
D3869_RS13370	COG0535	radical SAM domain protein
D3869_RS13375	COG0535	radical SAM domain protein
D3869_RS13380	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
D3869_RS13385	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D3869_RS13395	COG0148	phosphopyruvate hydratase activity
D3869_RS13405	COG0037	tRNA processing
D3869_RS13430	COG2986	histidine ammonia-lyase
D3869_RS13440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3869_RS13460	COG0596	Alpha beta hydrolase
D3869_RS13465	COG0728	peptidoglycan biosynthetic process
D3869_RS13475	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3869_RS13490	COG0436	Aminotransferase
D3869_RS13510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_RS13515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3869_RS13530	COG0745	RESPONSE REGULATOR receiver
D3869_RS13540	COG0745	RESPONSE REGULATOR receiver
D3869_RS13575	COG5001	Diguanylate cyclase
D3869_RS13575	COG5002	protein histidine kinase activity
D3869_RS13575	COG3447	MASE1 domain protein
D3869_RS13590	COG1324	tolerance protein
D3869_RS13610	COG1024	Enoyl-CoA hydratase
D3869_RS13620	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D3869_RS13625	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D3869_RS13630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D3869_RS13635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D3869_RS13640	COG2885	chlorophyll binding
D3869_RS13640	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D3869_RS13645	COG3243	poly(R)-hydroxyalkanoic acid synthase
D3869_RS13660	COG2814	Major facilitator Superfamily
D3869_RS13665	COG0436	Aminotransferase
D3869_RS13675	COG1494	fructose-1,6-bisphosphatase
D3869_RS13680	COG0371	Dehydrogenase
D3869_RS13685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D3869_RS13685	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D3869_RS13735	COG0656	L-ascorbic acid biosynthetic process
D3869_RS13750	COG0123	including yeast histone deacetylase and acetoin utilization protein
D3869_RS13760	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3869_RS13765	COG0517	IMP dehydrogenase activity
D3869_RS13800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_RS13805	COG0045	succinate-CoA ligase (ADP-forming) activity
D3869_RS13815	COG0583	DNA-binding transcription factor activity
D3869_RS13820	COG2814	Major facilitator Superfamily
D3869_RS13835	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D3869_RS13850	COG2084	Dehydrogenase
D3869_RS13855	COG3622	Belongs to the hyi family
D3869_RS13860	COG3960	tartronate-semialdehyde synthase activity
D3869_RS13865	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D3869_RS13865	COG0352	thiamine-phosphate diphosphorylase activity
D3869_RS13870	COG1802	Transcriptional regulator
D3869_RS13875	COG0469	pyruvate kinase activity
D3869_RS13885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3869_RS13885	COG0574	Belongs to the PEP-utilizing enzyme family
D3869_RS13915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3869_RS13925	COG0693	protein deglycase activity
D3869_RS13930	COG2197	response regulator
D3869_RS13935	COG2197	response regulator
D3869_RS13950	COG0829	nickel cation binding
D3869_RS13955	COG1819	glycosyl
D3869_RS13960	COG0831	urea catabolic process
D3869_RS13965	COG0832	Belongs to the urease beta subunit family
D3869_RS13970	COG0804	urea catabolic process
D3869_RS13995	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
D3869_RS14065	COG1561	YicC-like family, N-terminal region
D3869_RS14070	COG0300	oxidoreductase activity
D3869_RS14075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3869_RS14080	COG3932	Exopolysaccharide synthesis, ExoD
D3869_RS14085	COG0488	(ABC) transporter
D3869_RS14090	COG0105	UTP biosynthetic process
D3869_RS14105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D3869_RS14110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D3869_RS14120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3869_RS14125	COG0628	permease
D3869_RS14135	COG0300	oxidoreductase activity
D3869_RS14140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D3869_RS14165	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D3869_RS14170	COG0248	Ppx GppA phosphatase
D3869_RS14180	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D3869_RS14185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D3869_RS14205	COG5001	Diguanylate cyclase
D3869_RS14205	COG5002	protein histidine kinase activity
D3869_RS14205	COG3447	MASE1 domain protein
D3869_RS14210	COG2205	protein histidine kinase activity
D3869_RS14210	COG2202	Pas domain
D3869_RS14215	COG0784	Response regulator, receiver
D3869_RS14225	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D3869_RS14230	COG0793	Belongs to the peptidase S41A family
D3869_RS14235	COG0557	exoribonuclease II activity
D3869_RS14245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3869_RS14250	COG0758	DNA mediated transformation
D3869_RS14270	COG2814	Major facilitator Superfamily
D3869_RS14305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_RS14305	COG2205	protein histidine kinase activity
D3869_RS14310	COG0745	RESPONSE REGULATOR receiver
D3869_RS14345	COG0581	inorganic phosphate transmembrane transporter activity
D3869_RS14360	COG3842	ATPase activity
D3869_RS14370	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D3869_RS14375	COG1732	Glycine betaine
D3869_RS14380	COG1174	glycine betaine transport
D3869_RS14385	COG1125	glycine betaine transport
D3869_RS14390	COG1174	glycine betaine transport
D3869_RS14400	COG1652	LysM domain
D3869_RS14405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3869_RS14415	COG1024	Enoyl-CoA hydratase
D3869_RS14420	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D3869_RS14425	COG1609	Transcriptional regulator
D3869_RS14430	COG3265	gluconokinase activity
D3869_RS14445	COG1609	Transcriptional regulator
D3869_RS14450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3869_RS14455	COG1126	abc transporter atp-binding protein
D3869_RS14460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_RS14465	COG0765	amino acid transport
D3869_RS14470	COG0765	amino acid transport
D3869_RS14475	COG0303	'Molybdopterin
D3869_RS14495	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS14500	COG0730	response to heat
D3869_RS14515	COG0717	Belongs to the dCTP deaminase family
D3869_RS14525	COG0625	glutathione transferase activity
D3869_RS14530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3869_RS14550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3869_RS14550	COG2813	Specifically methylates the guanine in position
D3869_RS14555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3869_RS14565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3869_RS14570	COG0287	Prephenate dehydrogenase
D3869_RS14580	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D3869_RS14595	COG0583	DNA-binding transcription factor activity
D3869_RS14605	COG3634	alkyl hydroperoxide reductase activity
D3869_RS14610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3869_RS14615	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3869_RS14620	COG2080	2 iron, 2 sulfur cluster binding
D3869_RS14630	COG1988	membrane-bound metal-dependent
D3869_RS14650	COG0745	RESPONSE REGULATOR receiver
D3869_RS14660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3869_RS14665	COG0540	Belongs to the ATCase OTCase family
D3869_RS14680	COG0583	DNA-binding transcription factor activity
D3869_RS14700	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D3869_RS14715	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D3869_RS14725	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3869_RS14730	COG0154	amidase activity
D3869_RS14735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3869_RS14765	COG1733	regulation of RNA biosynthetic process
D3869_RS14770	COG0604	alcohol dehydrogenase
D3869_RS14770	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS14770	COG3321	synthase
D3869_RS14790	COG0628	permease
D3869_RS14795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3869_RS14880	COG1454	alcohol dehydrogenase
D3869_RS14885	COG1012	belongs to the aldehyde dehydrogenase family
D3869_RS14920	COG0583	DNA-binding transcription factor activity
D3869_RS14925	COG0583	DNA-binding transcription factor activity
D3869_RS14930	COG4221	oxidoreductase activity
D3869_RS14945	COG2080	2 iron, 2 sulfur cluster binding
D3869_RS14950	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3869_RS14955	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3869_RS14975	COG0583	DNA-binding transcription factor activity
D3869_RS15010	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3869_RS15015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_RS15025	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D3869_RS15030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3869_RS15040	COG0657	acetylesterase activity
D3869_RS15055	COG0667	Aldo Keto reductase
D3869_RS15060	COG0583	DNA-binding transcription factor activity
D3869_RS15100	COG2703	oxygen carrier activity
D3869_RS15115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D3869_RS15120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3869_RS15125	COG1127	ABC transporter
D3869_RS15145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3869_RS15150	COG1271	oxidase subunit
D3869_RS15155	COG1294	oxidase, subunit
D3869_RS15185	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS15210	COG2089	acid synthase
D3869_RS15215	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
D3869_RS15240	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS15245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3869_RS15250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3869_RS15250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3869_RS15260	COG0457	Tetratricopeptide repeat
D3869_RS15260	COG0859	PFAM glycosyl transferase family 9
D3869_RS15270	COG0457	Tetratricopeptide repeat
D3869_RS15270	COG0859	PFAM glycosyl transferase family 9
D3869_RS15320	COG0784	Response regulator, receiver
D3869_RS15345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3869_RS15355	COG1228	amidohydrolase
D3869_RS15370	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D3869_RS15385	COG2226	methyltransferase
D3869_RS15400	COG0747	negative chemotaxis
D3869_RS15410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_RS15415	COG0444	Belongs to the ABC transporter superfamily
D3869_RS15420	COG4608	Belongs to the ABC transporter superfamily
D3869_RS15455	COG1666	GTP binding
D3869_RS15510	COG1752	Esterase of the alpha-beta hydrolase superfamily
D3869_RS15515	COG1132	(ABC) transporter
D3869_RS15520	COG4191	Histidine kinase
D3869_RS15545	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D3869_RS15555	COG2264	protein methyltransferase activity
D3869_RS15560	COG0583	DNA-binding transcription factor activity
D3869_RS15565	COG0655	NAD(P)H dehydrogenase (quinone) activity
D3869_RS15570	COG0435	Glutathione S-transferase
D3869_RS15580	COG2197	response regulator
D3869_RS15590	COG0492	ferredoxin-NADP+ reductase activity
D3869_RS15605	COG0484	heat shock protein binding
D3869_RS15620	COG3038	cytochrome b561
D3869_RS15625	COG3240	lipase activity
D3869_RS15640	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3869_RS15650	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3869_RS15660	COG1846	Transcriptional regulator
D3869_RS15670	COG3920	Histidine kinase
D3869_RS15685	COG1758	RNA polymerase activity
D3869_RS15695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D3869_RS15700	COG0736	holo-[acyl-carrier-protein] synthase activity
D3869_RS15705	COG0681	Belongs to the peptidase S26 family
D3869_RS15710	COG0571	ribonuclease III activity
D3869_RS15715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D3869_RS15720	COG3106	COG3106 Predicted ATPase
D3869_RS15725	COG3768	UPF0283 membrane protein
D3869_RS15745	COG0740	serine-type endopeptidase activity
D3869_RS15750	COG1215	transferase activity, transferring glycosyl groups
D3869_RS15755	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3869_RS15765	COG1566	PFAM secretion protein HlyD family protein
D3869_RS15770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3869_RS15780	COG2308	Evidence 4 Homologs of previously reported genes of
D3869_RS15780	COG2307	Protein conserved in bacteria
D3869_RS15800	COG2017	converts alpha-aldose to the beta-anomer
D3869_RS15805	COG0515	serine threonine protein kinase
D3869_RS15805	COG2815	serine threonine protein kinase
D3869_RS15850	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D3869_RS15860	COG0513	Belongs to the DEAD box helicase family
D3869_RS15885	COG0187	DNA topoisomerase II activity
D3869_RS15890	COG1607	acyl-coa hydrolase
D3869_RS15895	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D3869_RS15900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3869_RS15905	COG0022	dehydrogenase e1 component
D3869_RS15905	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3869_RS15910	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3869_RS15915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3869_RS15920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D3869_RS15925	COG2867	negative regulation of translational initiation
D3869_RS15965	COG2204	response regulator
D3869_RS15975	COG0569	domain protein
D3869_RS15990	COG1923	regulation of RNA biosynthetic process
D3869_RS15995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3869_RS16010	COG0483	inositol monophosphate 1-phosphatase activity
D3869_RS16025	COG3956	TIGRFAM MazG family protein
D3869_RS16030	COG3260	NADH ubiquinone oxidoreductase 20
D3869_RS16035	COG0649	NAD binding
D3869_RS16040	COG0651	ATP synthesis coupled electron transport
D3869_RS16050	COG0650	Formate hydrogenlyase subunit 4
D3869_RS16055	COG0651	ATP synthesis coupled electron transport
D3869_RS16060	COG2183	response to ionizing radiation
D3869_RS16070	COG1280	lysine exporter protein (LysE YggA)
D3869_RS16115	COG0393	Putative heavy-metal-binding
D3869_RS16120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3869_RS16135	COG4166	transmembrane transport
D3869_RS16140	COG0625	glutathione transferase activity
D3869_RS16145	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3869_RS16150	COG0366	Alpha amylase catalytic
D3869_RS16170	COG0840	transmembrane signaling receptor activity
D3869_RS16205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3869_RS16215	COG0583	DNA-binding transcription factor activity
D3869_RS16220	COG4336	lyase activity
D3869_RS16235	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_RS16240	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D3869_RS16245	COG1984	allophanate hydrolase subunit 2
D3869_RS16250	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D3869_RS16265	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D3869_RS16270	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3869_RS16275	COG0058	SHG alpha-glucan phosphorylase activity
D3869_RS16325	COG5002	protein histidine kinase activity
D3869_RS16330	COG0745	RESPONSE REGULATOR receiver
D3869_RS16360	COG1959	2 iron, 2 sulfur cluster binding
D3869_RS16365	COG0719	Fe-S assembly protein
D3869_RS16370	COG0396	ATPase activity
D3869_RS16375	COG0719	Fe-S assembly protein
D3869_RS16380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3869_RS16385	COG0822	iron-sulfur transferase activity
D3869_RS16395	COG0316	Belongs to the HesB IscA family
D3869_RS16405	COG0308	aminopeptidase N
D3869_RS16425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D3869_RS16460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3869_RS16465	COG0697	spore germination
D3869_RS16475	COG2814	Major facilitator Superfamily
D3869_RS16480	COG0583	DNA-binding transcription factor activity
D3869_RS16495	COG3383	formate dehydrogenase (NAD+) activity
D3869_RS16500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3869_RS16520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3869_RS16525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3869_RS16550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3869_RS16560	COG0129	dihydroxy-acid dehydratase activity
D3869_RS16570	COG3920	Histidine kinase
D3869_RS16595	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D3869_RS16600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3869_RS16605	COG0534	Mate efflux family protein
D3869_RS16665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3869_RS16730	COG0629	single-stranded DNA binding
D3869_RS16735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3869_RS16755	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D3869_RS16770	COG1562	ergosterol biosynthetic process
D3869_RS16775	COG1562	ergosterol biosynthetic process
D3869_RS16780	COG1233	COG1233 Phytoene dehydrogenase and related
D3869_RS16790	COG3737	Protein of unknown function (DUF498/DUF598)
D3869_RS16800	COG1862	Preprotein translocase
D3869_RS16820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3869_RS16830	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3869_RS16840	COG0805	protein transport
D3869_RS16845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3869_RS16850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3869_RS16855	COG3842	ATPase activity
D3869_RS16860	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D3869_RS16865	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D3869_RS16870	COG1994	Peptidase M50
D3869_RS16875	COG1472	Belongs to the glycosyl hydrolase 3 family
D3869_RS16890	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D3869_RS16895	COG0316	Belongs to the HesB IscA family
D3869_RS16900	COG0708	Exodeoxyribonuclease III
D3869_RS16970	COG4372	Transposase
D3869_RS16975	COG3436	PFAM IS66 Orf2 family protein
D3869_RS17035	COG3177	Filamentation induced by cAMP protein fic
D3869_RS17065	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3869_RS17095	COG0519	Catalyzes the synthesis of GMP from XMP
D3869_RS17100	COG1247	-acetyltransferase
D3869_RS17135	COG3813	Protein conserved in bacteria
D3869_RS17140	COG0357	Ribosomal RNA small subunit methyltransferase G
D3869_RS17140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3869_RS17165	COG2814	Major facilitator Superfamily
D3869_RS17180	COG0066	3-isopropylmalate dehydratase activity
D3869_RS17185	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3869_RS17190	COG1053	succinate dehydrogenase
D3869_RS17195	COG1335	isochorismatase
D3869_RS17240	COG0683	leucine binding
D3869_RS17245	COG2188	Transcriptional regulator
D3869_RS17290	COG2198	Histidine kinase
D3869_RS17290	COG5002	protein histidine kinase activity
D3869_RS17290	COG0784	Response regulator, receiver
D3869_RS17310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3869_RS17320	COG0444	Belongs to the ABC transporter superfamily
D3869_RS17325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_RS17330	COG0601	transmembrane transport
D3869_RS17385	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D3869_RS17545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3869_RS17565	COG4771	TonB-dependent receptor
D3869_RS17585	COG1169	isochorismate synthase
D3869_RS17590	COG1021	2,3-dihydroxybenzoate-AMP ligase
D3869_RS17595	COG3433	isochorismatase activity
D3869_RS17595	COG1535	isochorismatase
D3869_RS17600	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS17610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3869_RS17615	COG2382	esterase
D3869_RS17625	COG1595	DNA-templated transcription, initiation
D3869_RS17635	COG1882	Formate acetyltransferase
D3869_RS17645	COG3008	intermembrane lipid transfer
D3869_RS17645	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D3869_RS17650	COG2995	paraquat-inducible protein a
D3869_RS17660	COG0457	Tetratricopeptide repeat
D3869_RS17660	COG0859	PFAM glycosyl transferase family 9
D3869_RS17665	COG0281	malic enzyme
D3869_RS17665	COG0280	phosphate acetyltransferase
D3869_RS17670	COG1301	dicarboxylic acid transport
D3869_RS17675	COG4191	Histidine kinase
D3869_RS17680	COG2204	response regulator
D3869_RS17700	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3869_RS17700	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3869_RS17705	COG1268	BioY protein
D3869_RS17710	COG4770	biotin carboxylase activity
D3869_RS17715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3869_RS17725	COG1794	racemase activity, acting on amino acids and derivatives
D3869_RS17745	COG1012	belongs to the aldehyde dehydrogenase family
D3869_RS17755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_RS17760	COG3976	FMN-binding domain protein
D3869_RS17760	COG1053	succinate dehydrogenase
D3869_RS17760	COG0431	NADPH-dependent FMN reductase
D3869_RS17780	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_RS17790	COG0745	RESPONSE REGULATOR receiver
D3869_RS17795	COG0745	RESPONSE REGULATOR receiver
D3869_RS17800	COG4251	negative regulation of phosphorylation
D3869_RS17810	COG1733	regulation of RNA biosynthetic process
D3869_RS17820	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS17860	COG0583	DNA-binding transcription factor activity
D3869_RS17870	COG2084	Dehydrogenase
D3869_RS17875	COG0300	oxidoreductase activity
D3869_RS17925	COG1396	sequence-specific DNA binding
D3869_RS17970	COG0247	lactate metabolic process
D3869_RS17970	COG0277	FAD linked oxidase domain protein
D3869_RS18005	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D3869_RS18015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D3869_RS18035	COG0425	Belongs to the sulfur carrier protein TusA family
D3869_RS18045	COG0640	Transcriptional regulator
D3869_RS18065	COG2857	Cytochrome c1
D3869_RS18065	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D3869_RS18080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D3869_RS18085	COG0408	coproporphyrinogen oxidase activity
D3869_RS18090	COG0617	tRNA 3'-terminal CCA addition
D3869_RS18110	COG0714	Associated with various cellular activities
D3869_RS18150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3869_RS18185	COG3436	PFAM IS66 Orf2 family protein
D3869_RS18190	COG4372	Transposase
D3869_RS18220	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D3869_RS18270	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS18275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3869_RS18335	COG2099	Precorrin-6x reductase
D3869_RS18365	COG1797	cobyrinic acid a,c-diamide synthase activity
D3869_RS18370	COG0778	Nitroreductase
D3869_RS18375	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS18380	COG1309	transcriptional regulator
D3869_RS18385	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3869_RS18390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3869_RS18395	COG0737	Belongs to the 5'-nucleotidase family
D3869_RS18400	COG4191	Histidine kinase
D3869_RS18400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_RS18420	COG1749	Flagellar hook protein flgE
D3869_RS18420	COG1749	Flagellar hook protein flgE
D3869_RS18445	COG0795	lipopolysaccharide-transporting ATPase activity
D3869_RS18450	COG0840	transmembrane signaling receptor activity
D3869_RS18455	COG1137	ATPase activity
D3869_RS18520	COG2723	6-phospho-beta-galactosidase activity
D3869_RS18535	COG2086	electron transfer activity
D3869_RS18545	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3869_RS18555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3869_RS18570	COG0019	diaminopimelate decarboxylase activity
D3869_RS18595	COG0772	Belongs to the SEDS family
D3869_RS18600	COG1253	flavin adenine dinucleotide binding
D3869_RS18610	COG2205	protein histidine kinase activity
D3869_RS18625	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D3869_RS18645	COG1657	PFAM Prenyltransferase squalene oxidase
D3869_RS18670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3869_RS18680	COG2217	Heavy metal translocating P-type atpase
D3869_RS18705	COG1741	Belongs to the pirin family
D3869_RS18710	COG2860	membrane
D3869_RS18720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3869_RS18725	COG0789	Transcriptional regulator
D3869_RS18740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3869_RS18745	COG4520	surface antigen
D3869_RS18790	COG1566	PFAM secretion protein HlyD family protein
D3869_RS18800	COG0583	DNA-binding transcription factor activity
D3869_RS18805	COG2814	Major facilitator Superfamily
D3869_RS18825	COG3273	potassium ion transport
D3869_RS18825	COG0471	metal ion transport
D3869_RS18855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_RS18865	COG0583	DNA-binding transcription factor activity
D3869_RS18870	COG3842	ATPase activity
D3869_RS18875	COG2182	Extracellular solute-binding protein
D3869_RS18880	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_RS18890	COG1917	Cupin 2, conserved barrel domain protein
D3869_RS18890	COG1396	sequence-specific DNA binding
D3869_RS18900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3869_RS18910	COG5507	3-demethylubiquinone-9 3-methyltransferase
D3869_RS18925	COG1309	transcriptional regulator
D3869_RS18950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3869_RS18960	COG1522	sequence-specific DNA binding
D3869_RS18965	COG1192	Involved in chromosome partitioning
D3869_RS18995	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D3869_RS19000	COG1530	ribonuclease E activity
D3869_RS19010	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D3869_RS19025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3869_RS19035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D3869_RS19050	COG4520	surface antigen
D3869_RS19085	COG0588	phosphoglycerate mutase activity
D3869_RS19100	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D3869_RS19110	COG3693	PFAM glycoside hydrolase, family 10
D3869_RS19120	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D3869_RS19145	COG1215	transferase activity, transferring glycosyl groups
D3869_RS19150	COG0438	transferase activity, transferring glycosyl groups
D3869_RS19155	COG0438	transferase activity, transferring glycosyl groups
D3869_RS19175	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_RS19180	COG0367	asparagine synthase
D3869_RS19185	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D3869_RS19230	COG4208	sulfate ABC transporter
D3869_RS19240	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D3869_RS19250	COG1959	2 iron, 2 sulfur cluster binding
D3869_RS19255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3869_RS19280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_RS19305	COG1573	uracil-dna glycosylase
D3869_RS19310	COG0741	lytic transglycosylase activity
D3869_RS19315	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3869_RS19350	COG0438	transferase activity, transferring glycosyl groups
D3869_RS19390	COG1960	acyl-CoA dehydrogenase activity
D3869_RS19400	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D3869_RS19415	COG0583	DNA-binding transcription factor activity
D3869_RS19420	COG2080	2 iron, 2 sulfur cluster binding
D3869_RS19425	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3869_RS19430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3869_RS19450	COG2900	Belongs to the SlyX family
D3869_RS19495	COG4520	surface antigen
D3869_RS19535	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3869_RS19535	COG0596	Alpha beta hydrolase
D3869_RS19540	COG0022	dehydrogenase e1 component
D3869_RS19545	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3869_RS19550	COG3199	ATP-NAD kinase
D3869_RS19555	COG3284	Transcriptional regulator
D3869_RS19585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3869_RS19590	COG1414	Transcriptional regulator
D3869_RS19595	COG2376	Dihydroxyacetone kinase
D3869_RS19635	COG0420	3'-5' exonuclease activity
D3869_RS19640	COG0419	ATPase involved in DNA repair
D3869_RS19645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3869_RS19655	COG1192	Involved in chromosome partitioning
D3869_RS19660	COG1475	DNA binding
D3869_RS19675	COG3707	response regulator
D3869_RS19680	COG1116	anion transmembrane transporter activity
D3869_RS19690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3869_RS19695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3869_RS19700	COG2146	nitrite reductase [NAD(P)H] activity
D3869_RS19705	COG0243	molybdopterin cofactor binding
D3869_RS19710	COG1648	precorrin-2 dehydrogenase activity
D3869_RS19710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3869_RS19715	COG0791	NLP P60 protein
D3869_RS19725	COG1032	radical SAM domain protein
D3869_RS19770	COG1609	Transcriptional regulator
D3869_RS19775	COG0583	DNA-binding transcription factor activity
D3869_RS19790	COG3648	Uricase
D3869_RS19790	COG3195	allantoin biosynthetic process
D3869_RS19800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3869_RS19820	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D3869_RS19860	COG0243	molybdopterin cofactor binding
D3869_RS19860	COG3383	formate dehydrogenase (NAD+) activity
D3869_RS19865	COG0437	4 iron, 4 sulfur cluster binding
D3869_RS19870	COG2864	formate dehydrogenase
D3869_RS19875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3869_RS19895	COG1116	anion transmembrane transporter activity
D3869_RS19900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_RS19910	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS19965	COG2223	nitrite transmembrane transporter activity
D3869_RS20000	COG1137	ATPase activity
D3869_RS20005	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D3869_RS20010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D3869_RS20015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3869_RS20020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3869_RS20025	COG0527	aspartate kinase activity
D3869_RS20030	COG2070	2-Nitropropane dioxygenase
D3869_RS20045	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D3869_RS20050	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D3869_RS20060	COG2852	Protein conserved in bacteria
D3869_RS20065	COG2890	protein-(glutamine-N5) methyltransferase activity
D3869_RS20085	COG0542	response to heat
D3869_RS20090	COG1272	protein, Hemolysin III
D3869_RS20100	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D3869_RS20115	COG0840	transmembrane signaling receptor activity
D3869_RS20120	COG5265	(ABC) transporter
D3869_RS20130	COG1703	isobutyryl-CoA mutase activity
D3869_RS20140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D3869_RS20150	COG2137	regulation of response to DNA damage stimulus
D3869_RS20155	COG0842	Transport permease protein
D3869_RS20160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3869_RS20165	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D3869_RS20180	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D3869_RS20185	COG0671	phosphoesterase, PA-phosphatase related
D3869_RS20200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D3869_RS20205	COG4774	siderophore transport
D3869_RS20210	COG3128	pkhd-type hydroxylase
D3869_RS20225	COG4604	ABC transporter, ATP-binding protein
D3869_RS20230	COG4605	iron ion homeostasis
D3869_RS20235	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3869_RS20240	COG4607	ABC-type enterochelin transport system periplasmic component
D3869_RS20245	COG1695	Transcriptional regulator
D3869_RS20285	COG1116	anion transmembrane transporter activity
D3869_RS20350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3869_RS20360	COG4206	TonB-dependent receptor
D3869_RS20395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3869_RS20400	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3869_RS20400	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3869_RS20405	COG1660	Displays ATPase and GTPase activities
D3869_RS20410	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D3869_RS20420	COG0642	Histidine kinase
D3869_RS20425	COG0745	RESPONSE REGULATOR receiver
D3869_RS20440	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D3869_RS20455	COG0739	heme binding
D3869_RS20490	COG3436	PFAM IS66 Orf2 family protein
D3869_RS20495	COG4372	Transposase
D3869_RS20515	COG1942	4-Oxalocrotonate Tautomerase
D3869_RS20520	COG0235	Class ii aldolase
D3869_RS20530	COG2205	protein histidine kinase activity
D3869_RS20535	COG0745	RESPONSE REGULATOR receiver
D3869_RS20550	COG0840	transmembrane signaling receptor activity
D3869_RS20560	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D3869_RS20570	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D3869_RS20595	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D3869_RS20600	COG2027	D-alanyl-D-alanine carboxypeptidase
D3869_RS20610	COG2091	lysine biosynthetic process via aminoadipic acid
D3869_RS20615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3869_RS20620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3869_RS20630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3869_RS20630	COG2111	Na H antiporter
D3869_RS20635	COG1006	Multisubunit Na H antiporter MnhC subunit
D3869_RS20640	COG0651	ATP synthesis coupled electron transport
D3869_RS20645	COG1863	multisubunit Na H antiporter MnhE subunit
D3869_RS20650	COG2212	antiporter activity
D3869_RS20655	COG1320	monovalent cation:proton antiporter activity
D3869_RS20695	COG4615	Cyclic peptide transporter
D3869_RS20725	COG0683	leucine binding
D3869_RS20755	COG3842	ATPase activity
D3869_RS20765	COG1175	transmembrane transport
D3869_RS20785	COG1024	Enoyl-CoA hydratase
D3869_RS20800	COG4221	oxidoreductase activity
D3869_RS20805	COG1609	Transcriptional regulator
D3869_RS20835	COG1966	Carbon starvation protein
D3869_RS20840	COG2879	small protein
D3869_RS20860	COG3243	poly(R)-hydroxyalkanoic acid synthase
D3869_RS20870	COG4651	solute:proton antiporter activity
D3869_RS20870	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3869_RS20900	COG0784	Response regulator, receiver
D3869_RS20900	COG4191	Histidine kinase
D3869_RS20925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3869_RS20930	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3869_RS20945	COG2204	response regulator
D3869_RS20965	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D3869_RS21025	COG4566	intracellular signal transduction
D3869_RS21030	COG4191	Histidine kinase
D3869_RS21035	COG1335	isochorismatase
D3869_RS21100	COG0625	glutathione transferase activity
D3869_RS21105	COG0583	DNA-binding transcription factor activity
D3869_RS21110	COG4948	Mandelate Racemase Muconate Lactonizing
D3869_RS21120	COG0288	reversible hydration of carbon dioxide
D3869_RS21130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D3869_RS21135	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D3869_RS21145	COG0583	DNA-binding transcription factor activity
D3869_RS21155	COG1283	sodium-dependent phosphate transmembrane transporter activity
D3869_RS21215	COG0306	phosphate transporter
D3869_RS21220	COG1392	Phosphate transport regulator
D3869_RS21230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3869_RS21255	COG2223	nitrite transmembrane transporter activity
D3869_RS21285	COG0612	Peptidase, M16
D3869_RS21295	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D3869_RS21315	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3869_RS21325	COG0488	(ABC) transporter
D3869_RS21340	COG2249	NAD(P)H dehydrogenase (quinone) activity
D3869_RS21345	COG0583	DNA-binding transcription factor activity
D3869_RS21355	COG0586	Pfam SNARE associated Golgi protein
D3869_RS21385	COG2884	Cell division ATP-binding protein ftsE
D3869_RS21420	COG5001	Diguanylate cyclase
D3869_RS21425	COG1381	Involved in DNA repair and RecF pathway recombination
D3869_RS21430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3869_RS21435	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3869_RS21440	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3869_RS21440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_RS21460	COG2308	Evidence 4 Homologs of previously reported genes of
D3869_RS21465	COG1360	Flagellar Motor Protein
D3869_RS21470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3869_RS21480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3869_RS21505	COG0784	Response regulator, receiver
D3869_RS21505	COG2198	Histidine kinase
D3869_RS21505	COG0643	Histidine kinase
D3869_RS21510	COG0835	chemotaxis
D3869_RS21515	COG2198	Histidine kinase
D3869_RS21515	COG0784	Response regulator, receiver
D3869_RS21515	COG0643	Histidine kinase
D3869_RS21530	COG0583	DNA-binding transcription factor activity
D3869_RS21540	COG0745	RESPONSE REGULATOR receiver
D3869_RS21560	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D3869_RS21575	COG0552	protein localization to endoplasmic reticulum
D3869_RS21580	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3869_RS21585	COG2204	response regulator
D3869_RS21590	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D3869_RS21595	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3869_RS21605	COG1766	The M ring may be actively involved in energy transduction
D3869_RS21610	COG1396	sequence-specific DNA binding
D3869_RS21655	COG1686	Belongs to the peptidase S11 family
D3869_RS21670	COG1840	ABC-type Fe3 transport system, periplasmic component
D3869_RS21675	COG4149	molybdate abc transporter
D3869_RS21680	COG3842	ATPase activity
D3869_RS21695	COG2391	methyltransferase activity
D3869_RS21700	COG0583	DNA-binding transcription factor activity
D3869_RS21705	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D3869_RS21710	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D3869_RS21715	COG2358	TRAP transporter, solute receptor (TAXI family
D3869_RS21740	COG0246	Mannitol dehydrogenase
D3869_RS21745	COG2721	sulfolactate sulfo-lyase activity
D3869_RS21750	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_RS21760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_RS21765	COG1063	alcohol dehydrogenase
D3869_RS21810	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D3869_RS21810	COG3264	Mechanosensitive ion channel
D3869_RS21825	COG0386	Belongs to the glutathione peroxidase family
D3869_RS21835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3869_RS21845	COG0837	glucose binding
D3869_RS21845	COG1737	Transcriptional regulator
D3869_RS21850	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3869_RS21855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_RS21860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_RS21870	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3869_RS21885	COG0436	Aminotransferase
D3869_RS21890	COG2202	Pas domain
D3869_RS21890	COG2205	protein histidine kinase activity
D3869_RS21895	COG2373	Large extracellular alpha-helical protein
D3869_RS21910	COG0183	Belongs to the thiolase family
D3869_RS21915	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3869_RS21915	COG1024	Enoyl-CoA hydratase
D3869_RS21920	COG1960	acyl-CoA dehydrogenase activity
D3869_RS21935	COG3047	cAMP biosynthetic process
D3869_RS21955	COG1196	nuclear chromosome segregation
D3869_RS21970	COG1194	a g-specific adenine glycosylase
D3869_RS21990	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D3869_RS22000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3869_RS22000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_RS22005	COG3012	SEC-C Motif Domain Protein
D3869_RS22010	COG1278	Cold shock
D3869_RS22015	COG0793	Belongs to the peptidase S41A family
D3869_RS22025	COG0309	Hydrogenase expression formation protein (HypE)
D3869_RS22030	COG0298	carbon dioxide binding
D3869_RS22045	COG0375	protein maturation
D3869_RS22055	COG1773	rubredoxin
D3869_RS22060	COG0298	carbon dioxide binding
D3869_RS22075	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3869_RS22080	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D3869_RS22085	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D3869_RS22090	COG5557	Pfam Polysulphide reductase, NrfD
D3869_RS22095	COG0437	4 iron, 4 sulfur cluster binding
D3869_RS22100	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D3869_RS22115	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D3869_RS22140	COG4178	(ABC) transporter
D3869_RS22150	COG0625	glutathione transferase activity
D3869_RS22180	COG1640	4-alpha-glucanotransferase
D3869_RS22195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3869_RS22205	COG2205	protein histidine kinase activity
D3869_RS22210	COG0745	RESPONSE REGULATOR receiver
D3869_RS22215	COG0784	Response regulator, receiver
D3869_RS22215	COG2205	protein histidine kinase activity
D3869_RS22215	COG2198	Histidine kinase
D3869_RS22220	COG1278	Cold shock
D3869_RS22230	COG1846	Transcriptional regulator
D3869_RS22235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3869_RS22240	COG0556	nucleotide-excision repair
D3869_RS22260	COG2205	protein histidine kinase activity
D3869_RS22270	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3869_RS22300	COG0741	lytic transglycosylase activity
D3869_RS22340	COG1309	transcriptional regulator
D3869_RS22355	COG1418	mRNA catabolic process
D3869_RS22360	COG1131	(ABC) transporter
D3869_RS22365	COG0842	Transport permease protein
D3869_RS22370	COG3791	Glutathione-dependent formaldehyde-activating
D3869_RS22375	COG0154	amidase activity
D3869_RS22380	COG0154	amidase activity
D3869_RS22385	COG1335	isochorismatase
D3869_RS22390	COG0747	negative chemotaxis
D3869_RS22395	COG0601	transmembrane transport
D3869_RS22400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_RS22410	COG4608	Belongs to the ABC transporter superfamily
D3869_RS22415	COG1335	isochorismatase
D3869_RS22420	COG3180	Ammonia monooxygenase
D3869_RS22425	COG1802	Transcriptional regulator
D3869_RS22435	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D3869_RS22440	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D3869_RS22445	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D3869_RS22450	COG2205	protein histidine kinase activity
D3869_RS22460	COG0861	Integral membrane protein TerC family
D3869_RS22470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_RS22475	COG2353	YceI-like domain
D3869_RS22495	COG4566	intracellular signal transduction
D3869_RS22500	COG4566	intracellular signal transduction
D3869_RS22505	COG4191	Histidine kinase
D3869_RS22520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3869_RS22525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3869_RS22545	COG0339	signal peptide processing
D3869_RS22550	COG4175	Glycine betaine
D3869_RS22555	COG4176	ABC-type proline glycine betaine transport system permease component
D3869_RS22560	COG2113	Glycine betaine
D3869_RS22580	COG1764	response to oxidative stress
D3869_RS22585	COG1846	Transcriptional regulator
D3869_RS22605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_RS22610	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3869_RS22630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3869_RS22680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3869_RS22685	COG0392	lysyltransferase activity
D3869_RS22700	COG5001	Diguanylate cyclase
D3869_RS22715	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D3869_RS22730	COG0477	Major facilitator Superfamily
D3869_RS22735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3869_RS22740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3869_RS22745	COG1845	cytochrome c oxidase, subunit III
D3869_RS22750	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D3869_RS22765	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D3869_RS22780	COG3005	denitrification pathway
D3869_RS22805	COG4459	periplasmic nitrate reductase
D3869_RS22820	COG0670	Belongs to the BI1 family
D3869_RS22850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_RS22860	COG1850	ribulose-bisphosphate carboxylase activity
D3869_RS22870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_RS22875	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_RS22890	COG3246	L-lysine catabolic process to acetate
D3869_RS22895	COG0028	Belongs to the TPP enzyme family
D3869_RS22915	COG4172	Belongs to the ABC transporter superfamily
D3869_RS22920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_RS22935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3869_RS22940	COG0583	DNA-binding transcription factor activity
D3869_RS22970	COG0438	transferase activity, transferring glycosyl groups
D3869_RS22990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3869_RS23010	COG0438	transferase activity, transferring glycosyl groups
D3869_RS23015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3869_RS23020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3869_RS23025	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3869_RS23040	COG2197	response regulator
D3869_RS23045	COG2197	response regulator
D3869_RS23055	COG3387	PFAM Glycoside hydrolase 15-related
D3869_RS23080	COG2226	methyltransferase
D3869_RS23095	COG0784	Response regulator, receiver
D3869_RS23095	COG5002	protein histidine kinase activity
D3869_RS23100	COG0154	amidase activity
D3869_RS23110	COG2351	hydroxyisourate hydrolase activity
D3869_RS23120	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_RS23130	COG3842	ATPase activity
D3869_RS23155	COG0154	amidase activity
D3869_RS23175	COG0402	S-adenosylhomocysteine deaminase activity
D3869_RS23180	COG1116	anion transmembrane transporter activity
D3869_RS23185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_RS23225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D3869_RS23235	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D3869_RS23280	COG1653	transport
D3869_RS23295	COG3842	ATPase activity
D3869_RS23310	COG0431	NADPH-dependent FMN reductase
D3869_RS23315	COG0840	transmembrane signaling receptor activity
D3869_RS23315	COG0840	transmembrane signaling receptor activity
D3869_RS23355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3869_RS23360	COG1473	amidohydrolase
D3869_RS23375	COG4122	O-methyltransferase activity
D3869_RS23405	COG1971	Probably functions as a manganese efflux pump
D3869_RS23410	COG3290	protein histidine kinase activity
D3869_RS23410	COG0840	transmembrane signaling receptor activity
D3869_RS23435	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS23440	COG0366	Alpha amylase catalytic
D3869_RS23445	COG2388	GCN5-related N-acetyl-transferase
D3869_RS23465	COG1139	Iron-sulfur cluster binding protein
D3869_RS23470	COG0247	lactate metabolic process
D3869_RS23475	COG0277	FAD linked oxidase domain protein
D3869_RS23480	COG1620	l-lactate permease
D3869_RS23485	COG2186	Transcriptional regulator
D3869_RS23495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3869_RS23500	COG0542	response to heat
D3869_RS23505	COG1414	Transcriptional regulator
D3869_RS23510	COG3734	2-keto-3-deoxy-galactonokinase
D3869_RS23515	COG0800	Aldolase
D3869_RS23540	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS23565	COG5002	protein histidine kinase activity
D3869_RS23565	COG0784	Response regulator, receiver
D3869_RS23565	COG2205	protein histidine kinase activity
D3869_RS23575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_RS23615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D3869_RS23620	COG4191	Histidine kinase
D3869_RS23625	COG4566	intracellular signal transduction
D3869_RS23635	COG0848	biopolymer transport protein
D3869_RS23675	COG3275	phosphorelay sensor kinase activity
D3869_RS23685	COG1966	Carbon starvation protein
D3869_RS23695	COG1363	Peptidase, m42
D3869_RS23700	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3869_RS23700	COG0189	ligase activity
D3869_RS23700	COG2918	glutathione biosynthetic process
D3869_RS23705	COG0367	asparagine synthase
D3869_RS23745	COG1802	Transcriptional regulator
D3869_RS23750	COG0617	tRNA 3'-terminal CCA addition
D3869_RS23750	COG0517	IMP dehydrogenase activity
D3869_RS23750	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D3869_RS23760	COG0861	Integral membrane protein TerC family
D3869_RS23830	COG2226	methyltransferase
D3869_RS23850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3869_RS23865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D3869_RS23870	COG1846	Transcriptional regulator
D3869_RS23880	COG1309	transcriptional regulator
D3869_RS23885	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_RS23890	COG2186	Transcriptional regulator
D3869_RS23895	COG1960	acyl-CoA dehydrogenase activity
D3869_RS23905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3869_RS23940	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_RS23950	COG1960	acyl-CoA dehydrogenase activity
D3869_RS23960	COG0183	Belongs to the thiolase family
D3869_RS23965	COG1960	acyl-CoA dehydrogenase activity
D3869_RS23970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3869_RS23975	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D3869_RS23980	COG4770	biotin carboxylase activity
D3869_RS24010	COG2819	hydrolase of the alpha beta superfamily
D3869_RS24030	COG2723	6-phospho-beta-galactosidase activity
D3869_RS24035	COG2723	6-phospho-beta-galactosidase activity
D3869_RS24040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D3869_RS24050	COG4178	(ABC) transporter
D3869_RS24060	COG1216	Glycosyl transferase, family 2
D3869_RS24060	COG1442	glycosyl transferase family 8
D3869_RS24070	COG2723	6-phospho-beta-galactosidase activity
D3869_RS24080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3869_RS24100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3869_RS24115	COG2197	response regulator
D3869_RS24125	COG2198	Histidine kinase
D3869_RS24125	COG0643	Histidine kinase
D3869_RS24135	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D3869_RS24145	COG2201	protein-glutamate methylesterase activity
D3869_RS24150	COG0835	chemotaxis
D3869_RS24170	COG2095	MarC family integral membrane protein
D3869_RS24195	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS24200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D3869_RS24215	COG0395	ABC-type sugar transport system, permease component
D3869_RS24240	COG0586	Pfam SNARE associated Golgi protein
D3869_RS24260	COG4615	Cyclic peptide transporter
D3869_RS24295	COG3290	protein histidine kinase activity
D3869_RS24295	COG0840	transmembrane signaling receptor activity
D3869_RS24325	COG0784	Response regulator, receiver
D3869_RS24325	COG5002	protein histidine kinase activity
D3869_RS24330	COG0784	Response regulator, receiver
D3869_RS24330	COG4191	Histidine kinase
D3869_RS24380	COG0668	transmembrane transport
D3869_RS24460	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3869_RS24465	COG1960	acyl-CoA dehydrogenase activity
D3869_RS24470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3869_RS24475	COG1764	response to oxidative stress
D3869_RS24495	COG0457	Tetratricopeptide repeat
D3869_RS24505	COG3842	ATPase activity
D3869_RS24520	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS24545	COG0583	DNA-binding transcription factor activity
D3869_RS24570	COG1573	uracil-dna glycosylase
D3869_RS24595	COG2010	Cytochrome c
D3869_RS24655	COG1131	(ABC) transporter
D3869_RS24675	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
D3869_RS24680	COG1229	Formylmethanofuran dehydrogenase subunit A
D3869_RS24690	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3869_RS24700	COG0702	epimerase
D3869_RS24720	COG0189	ligase activity
D3869_RS24730	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
D3869_RS24805	COG4566	intracellular signal transduction
D3869_RS24810	COG4191	Histidine kinase
D3869_RS24820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3869_RS24860	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_RS24890	COG0183	Belongs to the thiolase family
D3869_RS24925	COG0683	leucine binding
D3869_RS24935	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3869_RS24940	COG0022	dehydrogenase e1 component
D3869_RS24940	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3869_RS24945	COG1024	Enoyl-CoA hydratase
D3869_RS24975	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D3869_RS24980	COG1595	DNA-templated transcription, initiation
D3869_RS24995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3869_RS25000	COG1136	(ABC) transporter
D3869_RS25000	COG0577	efflux transmembrane transporter activity
D3869_RS25015	COG1121	(ABC) transporter
D3869_RS25050	COG1126	abc transporter atp-binding protein
D3869_RS25075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_RS25080	COG4948	Mandelate Racemase Muconate Lactonizing
D3869_RS25085	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3869_RS25090	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_RS25095	COG1802	Transcriptional regulator
D3869_RS25135	COG5564	TIM-barrel signal transduction protein
D3869_RS25140	COG5441	Belongs to the UPF0261 family
D3869_RS25145	COG5564	TIM-barrel signal transduction protein
D3869_RS25145	COG2204	response regulator
D3869_RS25160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D3869_RS25165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3869_RS25200	COG1032	radical SAM domain protein
D3869_RS25235	COG3609	addiction module antidote protein, CC2985 family
D3869_RS25240	COG2205	protein histidine kinase activity
D3869_RS25240	COG0784	Response regulator, receiver
D3869_RS25255	COG2223	nitrite transmembrane transporter activity
D3869_RS25305	COG0489	protein tyrosine kinase activity
D3869_RS25315	COG4964	Belongs to the GSP D family
D3869_RS25370	COG3436	PFAM IS66 Orf2 family protein
D3869_RS25375	COG4372	Transposase
D3869_RS25420	COG1024	Enoyl-CoA hydratase
D3869_RS25430	COG3842	ATPase activity
D3869_RS25435	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_RS25440	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_RS25455	COG0427	acetyl-CoA hydrolase
D3869_RS25485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_RS25490	COG0765	amino acid transport
D3869_RS25545	COG4178	(ABC) transporter
D3869_RS25555	COG1475	DNA binding
D3869_RS25560	COG1192	Involved in chromosome partitioning
D3869_RS25565	COG4783	chaperone-mediated protein folding
D3869_RS25585	COG3622	Belongs to the hyi family
D3869_RS25605	COG1215	transferase activity, transferring glycosyl groups
D3869_RS25620	COG3307	-O-antigen
D3869_RS25625	COG3206	protein involved in exopolysaccharide biosynthesis
D3869_RS25625	COG0489	protein tyrosine kinase activity
D3869_RS25655	COG1216	Glycosyl transferase, family 2
D3869_RS25730	COG4566	intracellular signal transduction
D3869_RS25745	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS25755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3869_RS25765	COG1994	Peptidase M50
D3869_RS25765	COG0517	IMP dehydrogenase activity
D3869_RS25780	COG1522	sequence-specific DNA binding
D3869_RS25790	COG0583	DNA-binding transcription factor activity
D3869_RS25800	COG2271	Major facilitator Superfamily
D3869_RS25805	COG1802	Transcriptional regulator
D3869_RS25810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_RS25820	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_RS25820	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3869_RS25825	COG2354	Protein conserved in bacteria
D3869_RS25840	COG1309	transcriptional regulator
D3869_RS25855	COG1418	mRNA catabolic process
D3869_RS25860	COG1131	(ABC) transporter
D3869_RS25865	COG0842	Transport permease protein
D3869_RS25870	COG3791	Glutathione-dependent formaldehyde-activating
D3869_RS25875	COG0154	amidase activity
D3869_RS25880	COG0154	amidase activity
D3869_RS25880	COG0154	amidase activity
D3869_RS25915	COG1414	Transcriptional regulator
D3869_RS25920	COG0280	phosphate acetyltransferase
D3869_RS25940	COG1012	belongs to the aldehyde dehydrogenase family
D3869_RS25950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D3869_RS25955	COG0243	molybdopterin cofactor binding
D3869_RS25960	COG0437	4 iron, 4 sulfur cluster binding
D3869_RS25975	COG0028	Belongs to the TPP enzyme family
D3869_RS25980	COG1475	DNA binding
D3869_RS25985	COG1192	Involved in chromosome partitioning
D3869_RS26005	COG0546	phosphoglycolate phosphatase activity
D3869_RS26020	COG2855	membrane
D3869_RS26025	COG0583	DNA-binding transcription factor activity
D3869_RS26055	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D3869_RS26060	COG4191	Histidine kinase
D3869_RS26060	COG0784	Response regulator, receiver
D3869_RS26085	COG1012	belongs to the aldehyde dehydrogenase family
D3869_RS26090	COG0028	Belongs to the TPP enzyme family
D3869_RS26095	COG0583	DNA-binding transcription factor activity
D3869_RS26105	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS26110	COG0583	DNA-binding transcription factor activity
D3869_RS26115	COG0793	Belongs to the peptidase S41A family
D3869_RS26120	COG5487	UPF0391 membrane protein
D3869_RS26130	COG4191	Histidine kinase
D3869_RS26140	COG0028	Belongs to the TPP enzyme family
D3869_RS26150	COG1522	sequence-specific DNA binding
D3869_RS26170	COG3300	MHYT domain
D3869_RS26170	COG5001	Diguanylate cyclase
D3869_RS26185	COG2204	response regulator
D3869_RS26195	COG2985	domain, Protein
D3869_RS26210	COG3842	ATPase activity
D3869_RS26220	COG0588	phosphoglycerate mutase activity
D3869_RS26235	COG1012	belongs to the aldehyde dehydrogenase family
D3869_RS26235	COG1454	alcohol dehydrogenase
D3869_RS26325	COG1360	Flagellar Motor Protein
D3869_RS26330	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D3869_RS26340	COG4786	Flagellar basal body rod
D3869_RS26345	COG4786	Flagellar basal body rod
D3869_RS26350	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
D3869_RS26355	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D3869_RS26375	COG0243	molybdopterin cofactor binding
D3869_RS26385	COG3005	denitrification pathway
D3869_RS26460	COG1766	The M ring may be actively involved in energy transduction
D3869_RS26470	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3869_RS26475	COG1338	Plays a role in the flagellum-specific transport system
D3869_RS26485	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3869_RS26525	COG3416	Protein conserved in bacteria
D3869_RS26530	COG0628	permease
D3869_RS26540	COG1597	lipid kinase activity
D3869_RS26545	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS26550	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D3869_RS26555	COG1802	Transcriptional regulator
D3869_RS26575	COG0668	transmembrane transport
D3869_RS26630	COG2226	methyltransferase
D3869_RS26630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3869_RS26630	COG0596	Alpha beta hydrolase
D3869_RS26635	COG0183	Belongs to the thiolase family
D3869_RS26640	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS26670	COG2814	Major facilitator Superfamily
D3869_RS26685	COG3300	MHYT domain
D3869_RS26685	COG5001	Diguanylate cyclase
D3869_RS26690	COG0012	GTP binding
D3869_RS26710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3869_RS26710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3869_RS26780	COG3772	lysozyme
D3869_RS26860	COG0740	serine-type endopeptidase activity
D3869_RS26890	COG0250	Participates in transcription elongation, termination and antitermination
D3869_RS26920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3869_RS26920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3869_RS26920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3869_RS27005	COG4974	Belongs to the 'phage' integrase family
D3869_RS27015	COG2267	carboxylic ester hydrolase activity
D3869_RS27020	COG1131	(ABC) transporter
D3869_RS27050	COG3383	formate dehydrogenase (NAD+) activity
D3869_RS27055	COG1414	Transcriptional regulator
D3869_RS27080	COG4191	Histidine kinase
D3869_RS27085	COG0402	S-adenosylhomocysteine deaminase activity
D3869_RS27090	COG1079	Belongs to the binding-protein-dependent transport system permease family
D3869_RS27095	COG4603	Belongs to the binding-protein-dependent transport system permease family
D3869_RS27100	COG3845	ABC transporter
D3869_RS27110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3869_RS27135	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D3869_RS27190	COG2133	pyrroloquinoline quinone binding
D3869_RS27205	COG0583	DNA-binding transcription factor activity
D3869_RS27215	COG1733	regulation of RNA biosynthetic process
D3869_RS27220	COG0702	epimerase
D3869_RS27235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3869_RS27240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3869_RS27245	COG1309	transcriptional regulator
D3869_RS27255	COG2132	Multicopper oxidase
D3869_RS27260	COG5039	Polysaccharide pyruvyl transferase
D3869_RS27275	COG0725	ABC transporter, periplasmic molybdate-binding protein
D3869_RS27280	COG0246	Mannitol dehydrogenase
D3869_RS27300	COG2011	ABC-type metal ion transport system permease component
D3869_RS27305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D3869_RS27310	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_RS27330	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3869_RS27330	COG2010	Cytochrome c
D3869_RS27335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3869_RS27350	COG1254	Belongs to the acylphosphatase family
D3869_RS27375	COG2239	Acts as a magnesium transporter
D3869_RS27380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3869_RS27380	COG2022	thiamine diphosphate biosynthetic process
D3869_RS27395	COG2022	thiamine diphosphate biosynthetic process
D3869_RS27450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3869_RS27460	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D3869_RS27470	COG0191	fructose-bisphosphate aldolase activity
D3869_RS27505	COG0861	Integral membrane protein TerC family
D3869_RS27545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_RS27545	COG2205	protein histidine kinase activity
D3869_RS27560	COG2721	sulfolactate sulfo-lyase activity
D3869_RS27565	COG1904	glucuronate isomerase
D3869_RS27575	COG1802	Transcriptional regulator
D3869_RS27580	COG0667	Aldo Keto reductase
D3869_RS27585	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_RS27595	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_RS27600	COG1917	Cupin 2, conserved barrel domain protein
D3869_RS27605	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS27610	COG1802	Transcriptional regulator
D3869_RS27615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3869_RS27630	COG4214	carbohydrate transport
D3869_RS27670	COG1879	ABC-type sugar transport system periplasmic component
D3869_RS27675	COG1129	ABC transporter
D3869_RS27680	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3869_RS27685	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3869_RS27695	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D3869_RS27700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3869_RS27710	COG1496	oxidoreductase activity
D3869_RS27730	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_RS27735	COG1278	Cold shock
D3869_RS27740	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D3869_RS27745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3869_RS27750	COG0574	Belongs to the PEP-utilizing enzyme family
D3869_RS27750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3869_RS27760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D3869_RS27765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3869_RS27770	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D3869_RS27770	COG4106	trans-aconitate 2-methyltransferase activity
D3869_RS27780	COG0156	8-amino-7-oxononanoate synthase activity
D3869_RS27795	COG0564	pseudouridine synthase activity
D3869_RS27805	COG0484	heat shock protein binding
D3869_RS27840	COG1744	ABC transporter substrate-binding protein PnrA-like
D3869_RS27850	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS27860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3869_RS27865	COG4608	Belongs to the ABC transporter superfamily
D3869_RS27880	COG0601	transmembrane transport
D3869_RS27885	COG0747	negative chemotaxis
D3869_RS27895	COG2233	PERMEase
D3869_RS27900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3869_RS27905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3869_RS27915	COG1178	ABC-type Fe3 transport system permease component
D3869_RS27920	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_RS27925	COG3842	ATPase activity
D3869_RS27940	COG1045	serine acetyltransferase
D3869_RS27950	COG1595	DNA-templated transcription, initiation
D3869_RS27995	COG0784	Response regulator, receiver
D3869_RS28000	COG4251	negative regulation of phosphorylation
D3869_RS28020	COG4166	transmembrane transport
D3869_RS28035	COG0798	PFAM Bile acid sodium symporter
D3869_RS28050	COG2188	Transcriptional regulator
D3869_RS28065	COG0154	amidase activity
D3869_RS28080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_RS28085	COG1960	acyl-CoA dehydrogenase activity
D3869_RS28090	COG2079	MmgE PrpD family protein
D3869_RS28110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_RS28115	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS28130	COG1595	DNA-templated transcription, initiation
D3869_RS28160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3869_RS28205	COG1132	(ABC) transporter
D3869_RS28220	COG2199	diguanylate cyclase activity
D3869_RS28220	COG2203	Gaf domain
D3869_RS28240	COG0405	Gamma-glutamyltransferase
D3869_RS28270	COG1858	cytochrome C peroxidase
D3869_RS28295	COG4964	Belongs to the GSP D family
D3869_RS28405	COG1312	Catalyzes the dehydration of D-mannonate
D3869_RS28410	COG0246	Mannitol dehydrogenase
D3869_RS28435	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3869_RS28445	COG0148	phosphopyruvate hydratase activity
D3869_RS28450	COG1882	Formate acetyltransferase
D3869_RS28455	COG1737	Transcriptional regulator
D3869_RS28455	COG0837	glucose binding
D3869_RS28460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3869_RS28465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3869_RS28470	COG1309	transcriptional regulator
D3869_RS28475	COG1309	transcriptional regulator
D3869_RS28485	COG4251	negative regulation of phosphorylation
D3869_RS28490	COG0469	pyruvate kinase activity
D3869_RS28495	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3869_RS28500	COG2116	formate transmembrane transporter activity
D3869_RS28505	COG0697	spore germination
D3869_RS28510	COG1802	Transcriptional regulator
D3869_RS28515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_RS28525	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_RS28530	COG0861	Integral membrane protein TerC family
D3869_RS28575	COG1706	bacterial-type flagellum-dependent cell motility
D3869_RS28600	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3869_RS28605	COG1684	flagellar biosynthetic protein fliR
D3869_RS28610	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3869_RS28620	COG4794	Type iii secretion
D3869_RS28625	COG1677	Flagellar hook-basal body complex protein FliE
D3869_RS28630	COG1558	bacterial-type flagellum-dependent cell motility
D3869_RS28635	COG1815	bacterial-type flagellum-dependent cell motility
D3869_RS28655	COG2814	Major facilitator Superfamily
D3869_RS28675	COG5443	negative regulation of bacterial-type flagellum assembly
D3869_RS28685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3869_RS28710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3869_RS28715	COG1802	Transcriptional regulator
D3869_RS28730	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D3869_RS28735	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D3869_RS28740	COG1120	ATPase activity
D3869_RS28745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3869_RS28750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3869_RS28760	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D3869_RS28770	COG1845	cytochrome c oxidase, subunit III
D3869_RS28775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_RS28795	COG0567	Dehydrogenase, E1 component
D3869_RS28800	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3869_RS28815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3869_RS28825	COG0277	FAD linked oxidase domain protein
D3869_RS28830	COG2086	electron transfer activity
D3869_RS28855	COG0154	amidase activity
D3869_RS28910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3869_RS28925	COG0683	leucine binding
D3869_RS28930	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_RS28955	COG3473	Maleate cis-trans isomerase
D3869_RS28960	COG0596	Alpha beta hydrolase
D3869_RS28965	COG2309	aminopeptidase activity
D3869_RS28970	COG1335	isochorismatase
D3869_RS28980	COG1609	Transcriptional regulator
D3869_RS28985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3869_RS28985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3869_RS28990	COG1105	Belongs to the carbohydrate kinase PfkB family
D3869_RS28995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3869_RS28995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3869_RS29005	COG3920	Histidine kinase
D3869_RS29010	COG2197	response regulator
D3869_RS29040	COG0583	DNA-binding transcription factor activity
D3869_RS29055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3869_RS29060	COG1473	amidohydrolase
D3869_RS29100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3869_RS29105	COG0251	oxidation-reduction process
D3869_RS29110	COG1522	sequence-specific DNA binding
D3869_RS29115	COG1414	Transcriptional regulator
D3869_RS29120	COG1414	Transcriptional regulator
D3869_RS29125	COG0280	phosphate acetyltransferase
D3869_RS29145	COG1012	belongs to the aldehyde dehydrogenase family
D3869_RS29155	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D3869_RS29190	COG2814	Major facilitator Superfamily
D3869_RS29205	COG1609	Transcriptional regulator
D3869_RS29210	COG3608	succinylglutamate desuccinylase aspartoacylase
D3869_RS29215	COG0251	oxidation-reduction process
D3869_RS29230	COG4597	amino acid ABC transporter
D3869_RS29235	COG0765	amino acid transport
D3869_RS29270	COG0569	domain protein
D3869_RS29290	COG2610	gluconate transmembrane transporter activity
D3869_RS29310	COG0583	DNA-binding transcription factor activity
D3869_RS29315	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS29320	COG3959	Transketolase, thiamine diphosphate binding domain
D3869_RS29325	COG3958	Transketolase
D3869_RS29330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_RS29340	COG2084	Dehydrogenase
D3869_RS29345	COG4221	oxidoreductase activity
D3869_RS29365	COG0747	negative chemotaxis
D3869_RS29375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_RS29385	COG0251	oxidation-reduction process
D3869_RS29400	COG2175	clavaminate synthase activity
D3869_RS29405	COG1116	anion transmembrane transporter activity
D3869_RS29410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_RS29420	COG2175	clavaminate synthase activity
D3869_RS29430	COG4521	taurine ABC transporter
D3869_RS29435	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3869_RS29440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_RS29445	COG3119	arylsulfatase activity
D3869_RS29450	COG2175	clavaminate synthase activity
D3869_RS29460	COG4191	Histidine kinase
D3869_RS29460	COG0784	Response regulator, receiver
D3869_RS29470	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS29475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3869_RS29480	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D3869_RS29490	COG1252	NADH dehydrogenase
D3869_RS29505	COG0583	DNA-binding transcription factor activity
D3869_RS29515	COG3220	belongs to the UPF0276 family
D3869_RS29535	COG1024	Enoyl-CoA hydratase
D3869_RS29555	COG0477	Major facilitator Superfamily
D3869_RS29575	COG0058	SHG alpha-glucan phosphorylase activity
D3869_RS29580	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D3869_RS29645	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D3869_RS29675	COG0683	leucine binding
D3869_RS29715	COG0644	oxidoreductase
D3869_RS29745	COG1881	PFAM PEBP family protein
D3869_RS29770	COG0024	Methionine aminopeptidase
D3869_RS29790	COG0601	transmembrane transport
D3869_RS29800	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D3869_RS29815	COG0444	Belongs to the ABC transporter superfamily
D3869_RS29830	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
D3869_RS29835	COG4221	oxidoreductase activity
D3869_RS29865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3869_RS29870	COG1063	alcohol dehydrogenase
D3869_RS29875	COG4948	Mandelate Racemase Muconate Lactonizing
D3869_RS29880	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS29905	COG0583	DNA-binding transcription factor activity
D3869_RS29915	COG0604	alcohol dehydrogenase
D3869_RS29920	COG1309	transcriptional regulator
D3869_RS29935	COG3842	ATPase activity
D3869_RS29945	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_RS29955	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_RS29960	COG1024	Enoyl-CoA hydratase
D3869_RS29975	COG2814	Major facilitator Superfamily
D3869_RS30000	COG3177	Filamentation induced by cAMP protein fic
D3869_RS30005	COG3415	Transposase
D3869_RS30010	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS30045	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3869_RS30125	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D3869_RS30135	COG1846	Transcriptional regulator
D3869_RS30140	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS30150	COG0583	DNA-binding transcription factor activity
D3869_RS30170	COG0601	transmembrane transport
D3869_RS30175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_RS30180	COG0444	Belongs to the ABC transporter superfamily
D3869_RS30190	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS30205	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D3869_RS30210	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3869_RS30210	COG1902	pentaerythritol trinitrate reductase activity
D3869_RS30240	COG3436	PFAM IS66 Orf2 family protein
D3869_RS30245	COG4372	Transposase
D3869_RS30275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D3869_RS30295	COG0583	DNA-binding transcription factor activity
D3869_RS30305	COG1012	belongs to the aldehyde dehydrogenase family
D3869_RS30310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_RS30320	COG0477	Major facilitator Superfamily
D3869_RS30325	COG0583	DNA-binding transcription factor activity
D3869_RS30330	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS30340	COG0183	Belongs to the thiolase family
D3869_RS30345	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS30350	COG1024	Enoyl-CoA hydratase
D3869_RS30365	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS30370	COG0583	DNA-binding transcription factor activity
D3869_RS30375	COG1846	Transcriptional regulator
D3869_RS30380	COG1764	response to oxidative stress
D3869_RS30385	COG0596	Alpha beta hydrolase
D3869_RS30405	COG4977	sequence-specific DNA binding
D3869_RS30430	COG0523	cobalamin synthesis protein
D3869_RS30460	COG0583	DNA-binding transcription factor activity
D3869_RS30530	COG1192	Involved in chromosome partitioning
D3869_RS30535	COG1475	DNA binding
D3869_RS30545	COG0667	Aldo Keto reductase
D3869_RS30555	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_RS30575	COG1012	belongs to the aldehyde dehydrogenase family
D3869_RS30580	COG1024	Enoyl-CoA hydratase
D3869_RS30585	COG2186	Transcriptional regulator
D3869_RS30590	COG0747	negative chemotaxis
D3869_RS30595	COG2205	protein histidine kinase activity
D3869_RS30595	COG5002	protein histidine kinase activity
D3869_RS30595	COG0784	Response regulator, receiver
D3869_RS30600	COG2201	protein-glutamate methylesterase activity
D3869_RS30625	COG4774	siderophore transport
D3869_RS30635	COG1595	DNA-templated transcription, initiation
D3869_RS30655	COG0765	amino acid transport
D3869_RS30665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3869_RS30675	COG1126	abc transporter atp-binding protein
D3869_RS30685	COG1070	Carbohydrate kinase
D3869_RS30690	COG2115	Belongs to the xylose isomerase family
D3869_RS30695	COG0673	inositol 2-dehydrogenase activity
D3869_RS30705	COG1879	ABC-type sugar transport system periplasmic component
D3869_RS30710	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3869_RS30720	COG1940	carbohydrate kinase activity
D3869_RS30725	COG0251	oxidation-reduction process
D3869_RS30730	COG0583	DNA-binding transcription factor activity
D3869_RS30775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3869_RS30780	COG0402	S-adenosylhomocysteine deaminase activity
D3869_RS30795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3869_RS30805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3869_RS30815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3869_RS30820	COG0842	Transport permease protein
D3869_RS30820	COG1129	ABC transporter
D3869_RS30825	COG0842	Transport permease protein
D3869_RS30845	COG0745	RESPONSE REGULATOR receiver
D3869_RS30850	COG1120	ATPase activity
D3869_RS30855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3869_RS30865	COG3720	iron ion transport
D3869_RS30875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3869_RS30900	COG0583	DNA-binding transcription factor activity
D3869_RS30910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3869_RS30910	COG1017	nitric oxide dioxygenase activity
D3869_RS30915	COG0625	glutathione transferase activity
D3869_RS30920	COG1802	Transcriptional regulator
D3869_RS30930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3869_RS30970	COG3842	ATPase activity
D3869_RS30975	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_RS30980	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_RS30985	COG3938	Belongs to the proline racemase family
D3869_RS30990	COG1802	Transcriptional regulator
D3869_RS30995	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D3869_RS31000	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3869_RS31005	COG0066	3-isopropylmalate dehydratase activity
D3869_RS31020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_RS31080	COG3842	ATPase activity
D3869_RS31085	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D3869_RS31090	COG1349	DNA-binding transcription factor activity
D3869_RS31105	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS31120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_RS31130	COG1024	Enoyl-CoA hydratase
D3869_RS31135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_RS31140	COG0154	amidase activity
D3869_RS31150	COG2188	Transcriptional regulator
D3869_RS31155	COG3395	kinase activity
D3869_RS31160	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D3869_RS31165	COG1454	alcohol dehydrogenase
D3869_RS31170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3869_RS31185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_RS31195	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS31215	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D3869_RS31220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3869_RS31225	COG0697	spore germination
D3869_RS31240	COG2188	Transcriptional regulator
D3869_RS31265	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D3869_RS31305	COG0765	amino acid transport
D3869_RS31310	COG0765	amino acid transport
D3869_RS31340	COG0840	transmembrane signaling receptor activity
D3869_RS31345	COG2423	ornithine cyclodeaminase activity
D3869_RS31350	COG0657	acetylesterase activity
D3869_RS31380	COG2814	Major facilitator Superfamily
D3869_RS31395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3869_RS31400	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_RS31405	COG3842	ATPase activity
D3869_RS31415	COG0277	FAD linked oxidase domain protein
D3869_RS31435	COG0747	negative chemotaxis
D3869_RS31445	COG0601	transmembrane transport
D3869_RS31450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_RS31455	COG0444	Belongs to the ABC transporter superfamily
D3869_RS31460	COG4608	Belongs to the ABC transporter superfamily
D3869_RS31465	COG0697	spore germination
D3869_RS31470	COG1982	Orn Lys Arg decarboxylase major
D3869_RS31475	COG0583	DNA-binding transcription factor activity
D3869_RS31480	COG1335	isochorismatase
D3869_RS31490	COG1396	sequence-specific DNA binding
D3869_RS31490	COG1917	Cupin 2, conserved barrel domain protein
D3869_RS31505	COG1053	succinate dehydrogenase
D3869_RS31525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_RS31530	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D3869_RS31545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3869_RS31550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_RS31555	COG1396	sequence-specific DNA binding
D3869_RS31565	COG3256	nitric oxide reductase
D3869_RS31570	COG0714	Associated with various cellular activities
D3869_RS31590	COG4263	nitrous-oxide reductase activity
D3869_RS31605	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D3869_RS31620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3869_RS31645	COG0826	peptidase U32
D3869_RS31660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_RS31670	COG1132	(ABC) transporter
D3869_RS31685	COG1120	ATPase activity
D3869_RS31690	COG4774	siderophore transport
D3869_RS31700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3869_RS31730	COG0583	DNA-binding transcription factor activity
D3869_RS31735	COG2271	Major facilitator Superfamily
D3869_RS31755	COG1120	ATPase activity
D3869_RS31775	COG4774	siderophore transport
D3869_RS31790	COG4774	siderophore transport
D3869_RS31795	COG1595	DNA-templated transcription, initiation
D3869_RS31805	COG0583	DNA-binding transcription factor activity
D3869_RS31820	COG2124	cytochrome p450
D3869_RS31825	COG0633	Ferredoxin
D3869_RS31855	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3869_RS31860	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D3869_RS31870	COG2814	Major facilitator Superfamily
D3869_RS31880	COG0683	leucine binding
D3869_RS31895	COG0411	ABC transporter
D3869_RS31910	COG4566	intracellular signal transduction
D3869_RS31910	COG0745	RESPONSE REGULATOR receiver
D3869_RS31920	COG1278	Cold shock
D3869_RS31925	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3869_RS31930	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3869_RS31950	COG2204	response regulator
D3869_RS31955	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3869_RS31960	COG3246	L-lysine catabolic process to acetate
D3869_RS31965	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS31980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3869_RS31990	COG0583	DNA-binding transcription factor activity
D3869_RS32000	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_RS32010	COG1396	sequence-specific DNA binding
D3869_RS32015	COG0277	FAD linked oxidase domain protein
D3869_RS32035	COG0765	amino acid transport
D3869_RS32040	COG1126	abc transporter atp-binding protein
D3869_RS32055	COG3842	ATPase activity
D3869_RS32065	COG1177	transmembrane transport
D3869_RS32085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3869_RS32090	COG0251	oxidation-reduction process
D3869_RS32100	COG0251	oxidation-reduction process
D3869_RS32105	COG0861	Integral membrane protein TerC family
D3869_RS32120	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3869_RS32120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_RS32125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_RS32130	COG3250	beta-galactosidase activity
D3869_RS32145	COG2814	Major facilitator Superfamily
D3869_RS32160	COG1609	Transcriptional regulator
D3869_RS32165	COG3608	succinylglutamate desuccinylase aspartoacylase
D3869_RS32170	COG0251	oxidation-reduction process
D3869_RS32230	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D3869_RS32260	COG2089	acid synthase
D3869_RS32305	COG2226	methyltransferase
D3869_RS32310	COG0367	asparagine synthase
D3869_RS32320	COG0463	Glycosyl transferase, family 2
D3869_RS32345	COG0438	transferase activity, transferring glycosyl groups
D3869_RS32350	COG0500	methyltransferase
D3869_RS32355	COG0579	oxidoreductase
D3869_RS32375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D3869_RS32385	COG1215	transferase activity, transferring glycosyl groups
D3869_RS32395	COG0572	uridine kinase
D3869_RS32430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3869_RS32460	COG1091	dTDP-4-dehydrorhamnose reductase activity
D3869_RS32465	COG1088	dTDP-glucose 4,6-dehydratase activity
D3869_RS32470	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D3869_RS32475	COG0297	glycogen (starch) synthase activity
D3869_RS32525	COG1216	Glycosyl transferase, family 2
D3869_RS32525	COG0438	transferase activity, transferring glycosyl groups
D3869_RS32545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D3869_RS32630	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D3869_RS32630	COG0662	Cupin 2, conserved barrel domain protein
D3869_RS32635	COG0438	transferase activity, transferring glycosyl groups
D3869_RS32695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3869_RS32710	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3869_RS32730	COG1192	Involved in chromosome partitioning
D3869_RS32735	COG1475	DNA binding
D3869_RS32745	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3869_RS32760	COG1086	Polysaccharide biosynthesis protein
D3869_RS32770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3869_RS32785	COG0494	nUDIX hydrolase
D3869_RS32805	COG0528	UMP kinase activity
D3869_RS32810	COG0528	UMP kinase activity
D3869_RS32835	COG1088	dTDP-glucose 4,6-dehydratase activity
D3869_RS32870	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
D3869_RS32880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3869_RS32895	COG2089	acid synthase
D3869_RS32920	COG0281	malic enzyme