locus-tag	class	description
AMK58_RS00020	COG0792	nuclease activity
AMK58_RS00045	COG1366	Belongs to the anti-sigma-factor antagonist family
AMK58_RS00055	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AMK58_RS00095	COG2205	protein histidine kinase activity
AMK58_RS00095	COG0784	Response regulator, receiver
AMK58_RS00105	COG0180	Tryptophanyl-tRNA synthetase
AMK58_RS00110	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AMK58_RS00120	COG3012	SEC-C Motif Domain Protein
AMK58_RS00135	COG0110	maltose O-acetyltransferase activity
AMK58_RS00140	COG1309	transcriptional regulator
AMK58_RS00145	COG1028	Short-chain dehydrogenase reductase Sdr
AMK58_RS00160	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AMK58_RS00165	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AMK58_RS00170	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AMK58_RS00195	COG0438	transferase activity, transferring glycosyl groups
AMK58_RS00200	COG3706	GGDEF domain
AMK58_RS00215	COG1132	(ABC) transporter
AMK58_RS00220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMK58_RS00220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMK58_RS00245	COG0747	negative chemotaxis
AMK58_RS00250	COG0601	transmembrane transport
AMK58_RS00255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMK58_RS00265	COG1234	tRNA 3'-trailer cleavage
AMK58_RS00285	COG0745	RESPONSE REGULATOR receiver
AMK58_RS00360	COG0357	Ribosomal RNA small subunit methyltransferase G
AMK58_RS00365	COG0445	tRNA wobble uridine modification
AMK58_RS00375	COG3411	Ferredoxin
AMK58_RS00385	COG1331	Highly conserved protein containing a thioredoxin domain
AMK58_RS00390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AMK58_RS00400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMK58_RS00405	COG0237	dephospho-CoA kinase activity
AMK58_RS00430	COG1981	membrane
AMK58_RS00450	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AMK58_RS00455	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AMK58_RS00465	COG4395	Tim44
AMK58_RS00470	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AMK58_RS00525	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AMK58_RS00530	COG0488	(ABC) transporter
AMK58_RS00535	COG2205	protein histidine kinase activity
AMK58_RS00550	COG1556	Lactate utilization protein
AMK58_RS00555	COG1139	Iron-sulfur cluster binding protein
AMK58_RS00560	COG0247	lactate metabolic process
AMK58_RS00580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMK58_RS00585	COG1121	(ABC) transporter
AMK58_RS00595	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AMK58_RS00600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AMK58_RS00610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AMK58_RS00625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMK58_RS00630	COG0730	response to heat
AMK58_RS00655	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AMK58_RS00665	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AMK58_RS00670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AMK58_RS00700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMK58_RS00705	COG1702	phosphate starvation-inducible protein PhoH
AMK58_RS00715	COG1253	flavin adenine dinucleotide binding
AMK58_RS00720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AMK58_RS00725	COG1396	sequence-specific DNA binding
AMK58_RS00730	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMK58_RS00735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AMK58_RS00740	COG2329	Antibiotic biosynthesis monooxygenase
AMK58_RS00745	COG0779	Required for maturation of 30S ribosomal subunits
AMK58_RS00770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AMK58_RS00780	COG1185	polyribonucleotide nucleotidyltransferase activity
AMK58_RS00790	COG2321	neutral zinc metallopeptidase
AMK58_RS00800	COG1509	lysine 2,3-aminomutase activity
AMK58_RS00805	COG0584	glycerophosphoryl diester phosphodiesterase
AMK58_RS00820	COG1592	Rubrerythrin
AMK58_RS00850	COG0039	L-malate dehydrogenase activity
AMK58_RS00855	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AMK58_RS00860	COG4166	transmembrane transport
AMK58_RS00870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMK58_RS00875	COG2226	methyltransferase
AMK58_RS00880	COG0457	Tetratricopeptide repeat
AMK58_RS00880	COG0859	PFAM glycosyl transferase family 9
AMK58_RS00890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMK58_RS00900	COG1024	Enoyl-CoA hydratase
AMK58_RS00905	COG0268	Binds directly to 16S ribosomal RNA
AMK58_RS00910	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AMK58_RS00915	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AMK58_RS00920	COG3842	ATPase activity
AMK58_RS00940	COG1176	ABC-type spermidine putrescine transport system, permease component I
AMK58_RS00945	COG1177	transmembrane transport
AMK58_RS00960	COG2132	Multicopper oxidase
AMK58_RS01010	COG2217	Heavy metal translocating P-type atpase
AMK58_RS01015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMK58_RS01020	COG0280	phosphate acetyltransferase
AMK58_RS01020	COG0281	malic enzyme
AMK58_RS01025	COG5002	protein histidine kinase activity
AMK58_RS01030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AMK58_RS01035	COG0573	inorganic phosphate transmembrane transporter activity
AMK58_RS01045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMK58_RS01055	COG0745	RESPONSE REGULATOR receiver
AMK58_RS01070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AMK58_RS01080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMK58_RS01090	COG0756	dUTP diphosphatase activity
AMK58_RS01095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AMK58_RS01100	COG2204	response regulator
AMK58_RS01105	COG1278	Cold shock
AMK58_RS01110	COG2205	protein histidine kinase activity
AMK58_RS01110	COG0784	Response regulator, receiver
AMK58_RS01110	COG5002	protein histidine kinase activity
AMK58_RS01115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMK58_RS01120	COG1321	iron dependent repressor
AMK58_RS01120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMK58_RS01125	COG1121	(ABC) transporter
AMK58_RS01130	COG0803	Belongs to the bacterial solute-binding protein 9 family
AMK58_RS01165	COG2202	Pas domain
AMK58_RS01165	COG2205	protein histidine kinase activity
AMK58_RS01185	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AMK58_RS01190	COG1253	flavin adenine dinucleotide binding
AMK58_RS01205	COG0477	Major facilitator Superfamily
AMK58_RS01210	COG0583	DNA-binding transcription factor activity
AMK58_RS01215	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AMK58_RS01240	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AMK58_RS01255	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AMK58_RS01260	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AMK58_RS01265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMK58_RS01280	COG3437	response regulator, receiver
AMK58_RS01280	COG0784	Response regulator, receiver
AMK58_RS01290	COG0583	DNA-binding transcription factor activity
AMK58_RS01300	COG0481	GTPase activity
AMK58_RS01310	COG0297	glycogen (starch) synthase activity
AMK58_RS01315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AMK58_RS01320	COG0004	ammonium transporteR
AMK58_RS01345	COG3806	Anti-sigma factor
AMK58_RS01350	COG1595	DNA-templated transcription, initiation
AMK58_RS01360	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AMK58_RS01375	COG0137	argininosuccinate synthase activity
AMK58_RS01390	COG2897	thiosulfate sulfurtransferase activity
AMK58_RS01395	COG3339	Conserved Protein
AMK58_RS01400	COG0697	spore germination
AMK58_RS01405	COG4235	cytochrome complex assembly
AMK58_RS01410	COG3088	subunit of a heme lyase
AMK58_RS01415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMK58_RS01420	COG1138	Cytochrome C-type biogenesis protein
AMK58_RS01425	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AMK58_RS01435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMK58_RS01440	COG0583	DNA-binding transcription factor activity
AMK58_RS01450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AMK58_RS01455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMK58_RS01460	COG1573	uracil-dna glycosylase
AMK58_RS01470	COG2154	pterin-4-alpha-carbinolamine dehydratase
AMK58_RS01480	COG0598	Magnesium transport protein CorA
AMK58_RS01485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMK58_RS01490	COG1872	DUF167
AMK58_RS01535	COG2985	domain, Protein
AMK58_RS01540	COG4133	protoheme IX ABC transporter activity
AMK58_RS01545	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMK58_RS01555	COG1074	ATP-dependent DNA helicase activity
AMK58_RS01565	COG2887	Belongs to the helicase family. UvrD subfamily
AMK58_RS01570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMK58_RS01580	COG0802	atpase or kinase
AMK58_RS01610	COG1252	NADH dehydrogenase
AMK58_RS01615	COG2205	protein histidine kinase activity
AMK58_RS01625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMK58_RS01630	COG0133	tryptophan synthase activity
AMK58_RS01640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AMK58_RS01645	COG0285	dihydrofolate synthase activity
AMK58_RS01660	COG1028	Short-chain dehydrogenase reductase Sdr
AMK58_RS01670	COG2205	protein histidine kinase activity
AMK58_RS01675	COG0302	gtp cyclohydrolase
AMK58_RS01685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AMK58_RS01695	COG0302	gtp cyclohydrolase
AMK58_RS01700	COG2967	ApaG domain
AMK58_RS01730	COG0514	ATP-dependent DNA helicase (RecQ)
AMK58_RS01795	COG0443	Heat shock 70 kDa protein
AMK58_RS01800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AMK58_RS01885	COG0582	viral genome integration into host DNA
AMK58_RS01905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMK58_RS01920	COG2205	protein histidine kinase activity
AMK58_RS01920	COG5002	protein histidine kinase activity
AMK58_RS01920	COG0784	Response regulator, receiver
AMK58_RS01940	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AMK58_RS01945	COG4191	Histidine kinase
AMK58_RS01945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMK58_RS01955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMK58_RS01965	COG2885	chlorophyll binding
AMK58_RS01995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMK58_RS02025	COG0181	hydroxymethylbilane synthase activity
AMK58_RS02030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMK58_RS02045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMK58_RS02050	COG2350	Protein conserved in bacteria
AMK58_RS02065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMK58_RS02080	COG5508	conserved small protein
AMK58_RS02085	COG0501	Belongs to the peptidase M48B family
AMK58_RS02100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AMK58_RS02100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMK58_RS02110	COG0138	bifunctional purine biosynthesis protein purh
AMK58_RS02135	COG2264	protein methyltransferase activity
AMK58_RS02140	COG2902	Dehydrogenase
AMK58_RS02145	COG3437	response regulator, receiver
AMK58_RS02165	COG0679	Auxin Efflux Carrier
AMK58_RS02170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMK58_RS02185	COG3118	belongs to the thioredoxin family
AMK58_RS02190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AMK58_RS02195	COG2835	tetraacyldisaccharide 4'-kinase activity
AMK58_RS02230	COG1285	pathogenesis
AMK58_RS02235	COG2814	Major facilitator Superfamily
AMK58_RS02245	COG0784	Response regulator, receiver
AMK58_RS02245	COG2205	protein histidine kinase activity
AMK58_RS02265	COG0395	ABC-type sugar transport system, permease component
AMK58_RS02275	COG0625	glutathione transferase activity
AMK58_RS02295	COG0513	Belongs to the DEAD box helicase family
AMK58_RS02325	COG1366	Belongs to the anti-sigma-factor antagonist family
AMK58_RS02335	COG0745	RESPONSE REGULATOR receiver
AMK58_RS02370	COG1366	Belongs to the anti-sigma-factor antagonist family
AMK58_RS02375	COG0840	transmembrane signaling receptor activity
AMK58_RS02385	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AMK58_RS02395	COG0840	transmembrane signaling receptor activity
AMK58_RS02400	COG0835	chemotaxis
AMK58_RS02405	COG0643	Histidine kinase
AMK58_RS02405	COG2198	Histidine kinase
AMK58_RS02410	COG0745	RESPONSE REGULATOR receiver
AMK58_RS02420	COG5002	protein histidine kinase activity
AMK58_RS02430	COG5002	protein histidine kinase activity
AMK58_RS02430	COG2176	DNA-directed DNA polymerase activity
AMK58_RS02435	COG0745	RESPONSE REGULATOR receiver
AMK58_RS02450	COG2917	probably involved in intracellular septation
AMK58_RS02460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AMK58_RS02465	COG0552	protein localization to endoplasmic reticulum
AMK58_RS02470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMK58_RS02475	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AMK58_RS02525	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AMK58_RS02540	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AMK58_RS02545	COG3706	GGDEF domain
AMK58_RS02550	COG2205	protein histidine kinase activity
AMK58_RS02555	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMK58_RS02570	COG0045	succinate-CoA ligase (ADP-forming) activity
AMK58_RS02575	COG0039	L-malate dehydrogenase activity
AMK58_RS02590	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AMK58_RS02595	COG2076	Multidrug Resistance protein
AMK58_RS02605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMK58_RS02610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMK58_RS02610	COG1199	ATP-dependent helicase activity
AMK58_RS02625	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AMK58_RS02635	COG2972	Histidine kinase
AMK58_RS02635	COG0840	transmembrane signaling receptor activity
AMK58_RS02650	COG2084	Dehydrogenase
AMK58_RS02660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AMK58_RS02695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMK58_RS02780	COG0531	amino acid
AMK58_RS02800	COG3485	protocatechuate 3,4-dioxygenase
AMK58_RS02810	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AMK58_RS02820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AMK58_RS02840	COG3335	DDE superfamily endonuclease
AMK58_RS02845	COG3621	Patatin-like phospholipase
AMK58_RS02855	COG3328	transposase activity
AMK58_RS02870	COG1074	ATP-dependent DNA helicase activity
AMK58_RS03015	COG0167	dihydroorotate dehydrogenase activity
AMK58_RS03025	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMK58_RS03030	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AMK58_RS03035	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AMK58_RS03100	COG3119	arylsulfatase activity
AMK58_RS03135	COG0714	Associated with various cellular activities
AMK58_RS03145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMK58_RS03160	COG0583	DNA-binding transcription factor activity
AMK58_RS03165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMK58_RS03170	COG1024	Enoyl-CoA hydratase
AMK58_RS03180	COG0154	amidase activity
AMK58_RS03185	COG1028	Short-chain dehydrogenase reductase Sdr
AMK58_RS03205	COG0411	ABC transporter
AMK58_RS03235	COG1136	(ABC) transporter
AMK58_RS03265	COG2304	oxidoreductase activity
AMK58_RS03270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMK58_RS03310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMK58_RS03315	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AMK58_RS03325	COG0783	Belongs to the Dps family
AMK58_RS03335	COG0492	ferredoxin-NADP+ reductase activity
AMK58_RS03350	COG3660	Nucleoside-diphosphate-sugar epimerase
AMK58_RS03355	COG1522	sequence-specific DNA binding
AMK58_RS03365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMK58_RS03370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AMK58_RS03395	COG1674	ftsk spoiiie
AMK58_RS03415	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMK58_RS03425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMK58_RS03430	COG1028	Short-chain dehydrogenase reductase Sdr
AMK58_RS03435	COG1238	metal cluster binding
AMK58_RS03455	COG1012	belongs to the aldehyde dehydrogenase family
AMK58_RS03470	COG2205	protein histidine kinase activity
AMK58_RS03470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMK58_RS03480	COG1131	(ABC) transporter
AMK58_RS03530	COG1116	anion transmembrane transporter activity
AMK58_RS03570	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AMK58_RS03580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMK58_RS03585	COG2205	protein histidine kinase activity
AMK58_RS03585	COG0784	Response regulator, receiver
AMK58_RS03595	COG0745	RESPONSE REGULATOR receiver
AMK58_RS03600	COG2766	serine protein kinase
AMK58_RS03605	COG2718	Belongs to the UPF0229 family
AMK58_RS03610	COG2719	SpoVR family
AMK58_RS03625	COG1643	Atp-dependent helicase
AMK58_RS03630	COG1116	anion transmembrane transporter activity
AMK58_RS03650	COG0745	RESPONSE REGULATOR receiver
AMK58_RS03675	COG0330	HflC and HflK could
AMK58_RS03680	COG0628	permease
AMK58_RS03690	COG3180	Ammonia monooxygenase
AMK58_RS03695	COG2988	succinylglutamate desuccinylase activity
AMK58_RS03735	COG2205	protein histidine kinase activity
AMK58_RS03735	COG2202	Pas domain
AMK58_RS03745	COG2205	protein histidine kinase activity
AMK58_RS03755	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AMK58_RS03765	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AMK58_RS03795	COG2197	response regulator
AMK58_RS03800	COG2197	response regulator
AMK58_RS03805	COG0210	DNA helicase
AMK58_RS03820	COG2264	protein methyltransferase activity
AMK58_RS03830	COG0006	proline dipeptidase activity
AMK58_RS03830	COG0006	proline dipeptidase activity
AMK58_RS03835	COG0745	RESPONSE REGULATOR receiver
AMK58_RS03850	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMK58_RS03855	COG0497	DNA recombination
AMK58_RS03875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMK58_RS03890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AMK58_RS03895	COG0849	cell division
AMK58_RS03900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AMK58_RS03905	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMK58_RS03910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AMK58_RS03915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMK58_RS03925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AMK58_RS03940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMK58_RS03950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AMK58_RS03970	COG2001	Belongs to the MraZ family
AMK58_RS03990	COG0488	(ABC) transporter
AMK58_RS03995	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AMK58_RS04010	COG0277	FAD linked oxidase domain protein
AMK58_RS04015	COG2084	Dehydrogenase
AMK58_RS04030	COG0784	Response regulator, receiver
AMK58_RS04030	COG4191	Histidine kinase
AMK58_RS04055	COG0142	geranyltranstransferase activity
AMK58_RS04065	COG2890	protein-(glutamine-N5) methyltransferase activity
AMK58_RS04085	COG0752	glycyl-tRNA synthetase alpha subunit
AMK58_RS04090	COG0751	glycine-tRNA ligase activity
AMK58_RS04095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMK58_RS04100	COG1346	cytolysis
AMK58_RS04105	COG1380	Effector of murein hydrolase LrgA
AMK58_RS04110	COG1073	alpha beta
AMK58_RS04135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMK58_RS04145	COG2205	protein histidine kinase activity
AMK58_RS04175	COG3409	Peptidoglycan-binding domain 1 protein
AMK58_RS04175	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMK58_RS04180	COG3108	Peptidase M15
AMK58_RS04190	COG1396	sequence-specific DNA binding
AMK58_RS04195	COG0840	transmembrane signaling receptor activity
AMK58_RS04225	COG0511	ligase activity, forming carbon-carbon bonds
AMK58_RS04230	COG0439	Biotin carboxylase
AMK58_RS04235	COG3719	Belongs to the RNase T2 family
AMK58_RS04260	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AMK58_RS04285	COG1686	Belongs to the peptidase S11 family
AMK58_RS04300	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AMK58_RS04305	COG0746	molybdenum cofactor guanylyltransferase activity
AMK58_RS04330	COG3383	formate dehydrogenase (NAD+) activity
AMK58_RS04330	COG0243	molybdopterin cofactor binding
AMK58_RS04335	COG0437	4 iron, 4 sulfur cluster binding
AMK58_RS04360	COG0235	Class ii aldolase
AMK58_RS04370	COG3384	dioxygenase
AMK58_RS04380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AMK58_RS04385	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMK58_RS04390	COG0356	it plays a direct role in the translocation of protons across the membrane
AMK58_RS04400	COG1999	signal sequence binding
AMK58_RS04415	COG1702	phosphate starvation-inducible protein PhoH
AMK58_RS04420	COG0850	regulation of cytokinetic process
AMK58_RS04425	COG2894	cell division
AMK58_RS04430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AMK58_RS04450	COG0840	transmembrane signaling receptor activity
AMK58_RS04455	COG4948	Mandelate Racemase Muconate Lactonizing
AMK58_RS04465	COG1104	cysteine desulfurase activity
AMK58_RS04475	COG2154	pterin-4-alpha-carbinolamine dehydratase
AMK58_RS04490	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AMK58_RS04505	COG0840	transmembrane signaling receptor activity
AMK58_RS04515	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AMK58_RS04520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AMK58_RS04525	COG1278	Cold shock
AMK58_RS04535	COG0784	Response regulator, receiver
AMK58_RS04535	COG5002	protein histidine kinase activity
AMK58_RS04535	COG2205	protein histidine kinase activity
AMK58_RS04560	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AMK58_RS04615	COG5420	small protein containing a coiled-coil domain
AMK58_RS04630	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AMK58_RS04635	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AMK58_RS04690	COG0121	glutamine amidotransferase
AMK58_RS04705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AMK58_RS04730	COG5554	nitrogen fixation
AMK58_RS04745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMK58_RS04770	COG1309	transcriptional regulator
AMK58_RS04780	COG1131	(ABC) transporter
AMK58_RS04790	COG0842	Transport permease protein
AMK58_RS04795	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
AMK58_RS04805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AMK58_RS04810	COG0277	FAD linked oxidase domain protein
AMK58_RS04815	COG0277	FAD linked oxidase domain protein
AMK58_RS04820	COG0247	lactate metabolic process
AMK58_RS04840	COG1960	acyl-CoA dehydrogenase activity
AMK58_RS04855	COG0277	FAD linked oxidase domain protein
AMK58_RS04860	COG0009	L-threonylcarbamoyladenylate synthase
AMK58_RS04865	COG1192	Involved in chromosome partitioning
AMK58_RS04875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AMK58_RS04880	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AMK58_RS04895	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AMK58_RS04900	COG2945	thiolester hydrolase activity
AMK58_RS04905	COG1045	serine acetyltransferase
AMK58_RS04920	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AMK58_RS04925	COG0633	Ferredoxin
AMK58_RS04930	COG0482	sulfurtransferase activity
AMK58_RS04945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMK58_RS04970	COG4221	oxidoreductase activity
AMK58_RS04980	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AMK58_RS04990	COG2205	protein histidine kinase activity
AMK58_RS04990	COG0784	Response regulator, receiver
AMK58_RS05000	COG0745	RESPONSE REGULATOR receiver
AMK58_RS05025	COG0432	Pfam Uncharacterised protein family UPF0047
AMK58_RS05035	COG2951	lytic endotransglycosylase activity
AMK58_RS05055	COG1454	alcohol dehydrogenase
AMK58_RS05085	COG0456	acetyltransferase
AMK58_RS05100	COG0114	fumarate hydratase activity
AMK58_RS05115	COG5002	protein histidine kinase activity
AMK58_RS05115	COG5001	Diguanylate cyclase
AMK58_RS05120	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AMK58_RS05135	COG0205	6-phosphofructokinase activity
AMK58_RS05165	COG0288	reversible hydration of carbon dioxide
AMK58_RS05180	COG3321	synthase
AMK58_RS05180	COG1028	Short-chain dehydrogenase reductase Sdr
AMK58_RS05180	COG0604	alcohol dehydrogenase
AMK58_RS05225	COG0318	PFAM AMP-dependent synthetase and ligase
AMK58_RS05255	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AMK58_RS05260	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AMK58_RS05265	COG0343	queuine tRNA-ribosyltransferase activity
AMK58_RS05270	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AMK58_RS05275	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMK58_RS05280	COG0840	transmembrane signaling receptor activity
AMK58_RS05350	COG2201	protein-glutamate methylesterase activity
AMK58_RS05400	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AMK58_RS05405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AMK58_RS05410	COG0242	peptide deformylase activity
AMK58_RS05420	COG3070	regulator of competence-specific genes
AMK58_RS05435	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AMK58_RS05460	COG4120	Belongs to the binding-protein-dependent transport system permease family
AMK58_RS05475	COG0489	protein tyrosine kinase activity
AMK58_RS05480	COG0330	HflC and HflK could
AMK58_RS05485	COG0330	HflC and HflK could
AMK58_RS05510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMK58_RS05515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMK58_RS05520	COG0028	Belongs to the TPP enzyme family
AMK58_RS05535	COG0704	Plays a role in the regulation of phosphate uptake
AMK58_RS05540	COG2862	Uncharacterized protein family, UPF0114
AMK58_RS05560	COG0768	penicillin binding
AMK58_RS05580	COG1744	ABC transporter substrate-binding protein PnrA-like
AMK58_RS05585	COG3845	ABC transporter
AMK58_RS05590	COG4603	Belongs to the binding-protein-dependent transport system permease family
AMK58_RS05595	COG1079	Belongs to the binding-protein-dependent transport system permease family
AMK58_RS05600	COG0295	cytidine deaminase activity
AMK58_RS05605	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AMK58_RS05610	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AMK58_RS05625	COG0697	spore germination
AMK58_RS05645	COG0411	ABC transporter
AMK58_RS05660	COG0038	chloride channel
AMK58_RS05670	COG2326	polyphosphate kinase activity
AMK58_RS05675	COG0366	Alpha amylase catalytic
AMK58_RS05685	COG2203	Gaf domain
AMK58_RS05685	COG2200	EAL domain
AMK58_RS05685	COG2199	diguanylate cyclase activity
AMK58_RS05695	COG2135	peptidase activity
AMK58_RS05705	COG0784	Response regulator, receiver
AMK58_RS05710	COG2261	transglycosylase associated protein
AMK58_RS05715	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AMK58_RS05730	COG1733	regulation of RNA biosynthetic process
AMK58_RS05740	COG2084	Dehydrogenase
AMK58_RS05745	COG1028	Short-chain dehydrogenase reductase Sdr
AMK58_RS05760	COG0546	phosphoglycolate phosphatase activity
AMK58_RS05775	COG0521	Mo-molybdopterin cofactor biosynthetic process
AMK58_RS05785	COG2832	Protein of unknown function (DUF454)
AMK58_RS05790	COG1238	metal cluster binding
AMK58_RS05795	COG3852	Histidine kinase
AMK58_RS05800	COG0469	pyruvate kinase activity
AMK58_RS05805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AMK58_RS05820	COG0203	ribosomal protein L17
AMK58_RS05825	COG1238	metal cluster binding
AMK58_RS05840	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AMK58_RS05850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMK58_RS05855	COG0564	pseudouridine synthase activity
AMK58_RS05860	COG1802	Transcriptional regulator
AMK58_RS05865	COG3135	benzoate transporter
AMK58_RS05870	COG0546	phosphoglycolate phosphatase activity
AMK58_RS05895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMK58_RS05900	COG3845	ABC transporter
AMK58_RS05905	COG4603	Belongs to the binding-protein-dependent transport system permease family
AMK58_RS05910	COG1079	Belongs to the binding-protein-dependent transport system permease family
AMK58_RS05945	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AMK58_RS05950	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AMK58_RS05965	COG1028	Short-chain dehydrogenase reductase Sdr
AMK58_RS05970	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMK58_RS05975	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AMK58_RS05985	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMK58_RS05990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMK58_RS05995	COG0351	phosphomethylpyrimidine kinase
AMK58_RS06000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMK58_RS06015	COG0670	Belongs to the BI1 family
AMK58_RS06040	COG2030	dehydratase
AMK58_RS06040	COG1012	belongs to the aldehyde dehydrogenase family
AMK58_RS06045	COG0443	Heat shock 70 kDa protein
AMK58_RS06070	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AMK58_RS06070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMK58_RS06120	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMK58_RS06125	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMK58_RS06135	COG0649	NAD binding
AMK58_RS06140	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AMK58_RS06150	COG1034	ATP synthesis coupled electron transport
AMK58_RS06155	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AMK58_RS06160	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMK58_RS06170	COG0713	ATP synthesis coupled electron transport
AMK58_RS06185	COG1007	ATP synthesis coupled electron transport
AMK58_RS06205	COG0346	lactoylglutathione lyase activity
AMK58_RS06215	COG0519	Catalyzes the synthesis of GMP from XMP
AMK58_RS06230	COG0442	prolyl-tRNA aminoacylation
AMK58_RS06265	COG0052	Belongs to the universal ribosomal protein uS2 family
AMK58_RS06270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMK58_RS06275	COG0528	UMP kinase activity
AMK58_RS06280	COG0233	cytoplasmic translational termination
AMK58_RS06285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AMK58_RS06295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AMK58_RS06300	COG0750	zinc metalloprotease
AMK58_RS06320	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMK58_RS06325	COG3494	Protein of unknown function (DUF1009)
AMK58_RS06330	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMK58_RS06345	COG0583	DNA-binding transcription factor activity
AMK58_RS06360	COG0372	Belongs to the citrate synthase family
AMK58_RS06365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMK58_RS06370	COG2333	competence protein COMEC
AMK58_RS06370	COG0658	competence protein
AMK58_RS06375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMK58_RS06380	COG0303	'Molybdopterin
AMK58_RS06385	COG0315	cyclic pyranopterin monophosphate synthase activity
AMK58_RS06430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AMK58_RS06440	COG0149	triose-phosphate isomerase activity
AMK58_RS06470	COG0535	radical SAM domain protein
AMK58_RS06475	COG0535	radical SAM domain protein
AMK58_RS06480	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AMK58_RS06485	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AMK58_RS06495	COG0148	phosphopyruvate hydratase activity
AMK58_RS06505	COG0037	tRNA processing
AMK58_RS06540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMK58_RS06560	COG0596	Alpha beta hydrolase
AMK58_RS06565	COG0728	peptidoglycan biosynthetic process
AMK58_RS06575	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AMK58_RS06590	COG0436	Aminotransferase
AMK58_RS06610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMK58_RS06615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMK58_RS06630	COG0745	RESPONSE REGULATOR receiver
AMK58_RS06640	COG0745	RESPONSE REGULATOR receiver
AMK58_RS06645	COG0840	transmembrane signaling receptor activity
AMK58_RS06680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMK58_RS06710	COG1832	CoA-binding protein
AMK58_RS06715	COG1024	Enoyl-CoA hydratase
AMK58_RS06725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AMK58_RS06730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AMK58_RS06735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AMK58_RS06740	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AMK58_RS06745	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AMK58_RS06745	COG2885	chlorophyll binding
AMK58_RS06750	COG3243	poly(R)-hydroxyalkanoic acid synthase
AMK58_RS06765	COG2814	Major facilitator Superfamily
AMK58_RS06775	COG0436	Aminotransferase
AMK58_RS06785	COG1494	fructose-1,6-bisphosphatase
AMK58_RS06790	COG0371	Dehydrogenase
AMK58_RS06795	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AMK58_RS06795	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AMK58_RS06860	COG0656	L-ascorbic acid biosynthetic process
AMK58_RS06885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AMK58_RS06890	COG0517	IMP dehydrogenase activity
AMK58_RS06925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMK58_RS06930	COG0045	succinate-CoA ligase (ADP-forming) activity
AMK58_RS06940	COG2814	Major facilitator Superfamily
AMK58_RS06955	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AMK58_RS06970	COG2084	Dehydrogenase
AMK58_RS06975	COG3622	Belongs to the hyi family
AMK58_RS06980	COG3960	tartronate-semialdehyde synthase activity
AMK58_RS06985	COG0352	thiamine-phosphate diphosphorylase activity
AMK58_RS06985	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AMK58_RS06990	COG1802	Transcriptional regulator
AMK58_RS06995	COG0469	pyruvate kinase activity
AMK58_RS07005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMK58_RS07005	COG0574	Belongs to the PEP-utilizing enzyme family
AMK58_RS07035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMK58_RS07045	COG0693	protein deglycase activity
AMK58_RS07050	COG2197	response regulator
AMK58_RS07055	COG2197	response regulator
AMK58_RS07070	COG0829	nickel cation binding
AMK58_RS07075	COG0831	urea catabolic process
AMK58_RS07080	COG0832	Belongs to the urease beta subunit family
AMK58_RS07085	COG0804	urea catabolic process
AMK58_RS07090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AMK58_RS07095	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AMK58_RS07100	COG0830	nickel cation binding
AMK58_RS07105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AMK58_RS07110	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AMK58_RS07120	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AMK58_RS07135	COG0640	Transcriptional regulator
AMK58_RS07165	COG1396	sequence-specific DNA binding
AMK58_RS07190	COG1846	Transcriptional regulator
AMK58_RS07200	COG0704	Plays a role in the regulation of phosphate uptake
AMK58_RS07220	COG0463	Glycosyl transferase, family 2
AMK58_RS07240	COG1940	carbohydrate kinase activity
AMK58_RS07290	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AMK58_RS07290	COG2885	chlorophyll binding
AMK58_RS07295	COG2197	response regulator
AMK58_RS07300	COG2198	Histidine kinase
AMK58_RS07300	COG0784	Response regulator, receiver
AMK58_RS07300	COG2205	protein histidine kinase activity
AMK58_RS07315	COG0564	pseudouridine synthase activity
AMK58_RS07320	COG1028	Short-chain dehydrogenase reductase Sdr
AMK58_RS07325	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AMK58_RS07340	COG0024	Methionine aminopeptidase
AMK58_RS07355	COG1127	ABC transporter
AMK58_RS07360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMK58_RS07365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMK58_RS07370	COG0305	Participates in initiation and elongation during chromosome replication
AMK58_RS07375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMK58_RS07380	COG0359	binds to the 23S rRNA
AMK58_RS07390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AMK58_RS07395	COG0360	Binds together with S18 to 16S ribosomal RNA
AMK58_RS07400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AMK58_RS07415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMK58_RS07420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AMK58_RS07430	COG0741	lytic transglycosylase activity
AMK58_RS07435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMK58_RS07440	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AMK58_RS07445	COG2813	Specifically methylates the guanine in position
AMK58_RS07455	COG1881	PFAM PEBP family protein
AMK58_RS07460	COG0113	porphobilinogen synthase activity
AMK58_RS07465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AMK58_RS07470	COG1597	lipid kinase activity
AMK58_RS07475	COG1024	Enoyl-CoA hydratase
AMK58_RS07480	COG1846	Transcriptional regulator
AMK58_RS07500	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMK58_RS07515	COG0686	Belongs to the AlaDH PNT family
AMK58_RS07525	COG0737	Belongs to the 5'-nucleotidase family
AMK58_RS07530	COG0512	Glutamine amidotransferase of anthranilate synthase
AMK58_RS07535	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AMK58_RS07540	COG3608	succinylglutamate desuccinylase aspartoacylase
AMK58_RS07540	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AMK58_RS07575	COG2358	TRAP transporter, solute receptor (TAXI family
AMK58_RS07605	COG0123	including yeast histone deacetylase and acetoin utilization protein
AMK58_RS07650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AMK58_RS07655	COG0626	cystathionine gamma-synthase activity
AMK58_RS07660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMK58_RS07665	COG4597	amino acid ABC transporter
AMK58_RS07670	COG0765	amino acid transport
AMK58_RS07675	COG1126	abc transporter atp-binding protein
AMK58_RS07680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMK58_RS07700	COG2897	thiosulfate sulfurtransferase activity
AMK58_RS07715	COG0494	nUDIX hydrolase
AMK58_RS07720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMK58_RS07745	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AMK58_RS07755	COG1538	Outer membrane efflux protein
AMK58_RS07765	COG0525	valine-tRNA ligase activity
AMK58_RS07770	COG0840	transmembrane signaling receptor activity
AMK58_RS07785	COG1686	Belongs to the peptidase S11 family
AMK58_RS07790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AMK58_RS07795	COG0470	DNA polymerase III
AMK58_RS07805	COG0084	hydrolase, TatD family'
AMK58_RS07810	COG0321	lipoyl(octanoyl) transferase activity
AMK58_RS07810	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AMK58_RS07825	COG0631	protein serine/threonine phosphatase activity
AMK58_RS07835	COG2957	Belongs to the agmatine deiminase family
AMK58_RS07840	COG1177	transmembrane transport
AMK58_RS07845	COG1176	ABC-type spermidine putrescine transport system, permease component I
AMK58_RS07850	COG3842	ATPase activity
AMK58_RS07860	COG0174	glutamine synthetase
AMK58_RS07865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMK58_RS07895	COG0861	Integral membrane protein TerC family
AMK58_RS07905	COG4957	zinc ion binding
AMK58_RS07940	COG1280	lysine exporter protein (LysE YggA)
AMK58_RS07950	COG0314	molybdopterin synthase activity
AMK58_RS07955	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AMK58_RS07965	COG1763	Mo-molybdopterin cofactor biosynthetic process
AMK58_RS07970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMK58_RS07980	COG1028	Short-chain dehydrogenase reductase Sdr
AMK58_RS08025	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AMK58_RS08025	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AMK58_RS08030	COG1160	GTP binding
AMK58_RS08050	COG2197	response regulator
AMK58_RS08060	COG2197	response regulator
AMK58_RS08130	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AMK58_RS08135	COG2814	Major facilitator Superfamily
AMK58_RS08150	COG0789	Transcriptional regulator
AMK58_RS08155	COG0318	PFAM AMP-dependent synthetase and ligase
AMK58_RS08175	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AMK58_RS08185	COG1116	anion transmembrane transporter activity
AMK58_RS08185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMK58_RS08195	COG0175	sulfate reduction
AMK58_RS08200	COG0175	sulfate reduction
AMK58_RS08205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMK58_RS08205	COG1648	precorrin-2 dehydrogenase activity
AMK58_RS08220	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMK58_RS08235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AMK58_RS08235	COG4651	solute:proton antiporter activity
AMK58_RS08260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMK58_RS08265	COG0416	fatty acid biosynthetic process
AMK58_RS08270	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AMK58_RS08290	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AMK58_RS08300	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AMK58_RS08305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMK58_RS08310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AMK58_RS08315	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMK58_RS08315	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMK58_RS08325	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMK58_RS08325	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMK58_RS08330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMK58_RS08335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMK58_RS08340	COG0698	ribose 5-phosphate isomerase
AMK58_RS08360	COG3685	Protein conserved in bacteria
AMK58_RS08380	COG2153	protein acetylation
AMK58_RS08390	COG1793	dna ligase
AMK58_RS08400	COG2313	pseudouridylate synthase activity
AMK58_RS08410	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AMK58_RS08430	COG1217	gtp-binding protein TYPA
AMK58_RS08455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMK58_RS08475	COG1755	Isoprenylcysteine carboxyl methyltransferase
AMK58_RS08480	COG3424	synthase
AMK58_RS08495	COG3328	transposase activity
AMK58_RS08500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AMK58_RS08505	COG1492	cobalamin metabolic process
AMK58_RS08565	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AMK58_RS08575	COG1024	Enoyl-CoA hydratase
AMK58_RS08585	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMK58_RS08590	COG3411	Ferredoxin
AMK58_RS08610	COG3546	catalase activity
AMK58_RS08615	COG2211	Major facilitator Superfamily
AMK58_RS08620	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AMK58_RS08665	COG0546	phosphoglycolate phosphatase activity
AMK58_RS08680	COG3108	Peptidase M15
AMK58_RS08690	COG1773	rubredoxin
AMK58_RS08705	COG1752	Esterase of the alpha-beta hydrolase superfamily
AMK58_RS08710	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AMK58_RS08730	COG2202	Pas domain
AMK58_RS08730	COG2205	protein histidine kinase activity
AMK58_RS08760	COG2824	Alkylphosphonate utilization operon protein PhnA
AMK58_RS08775	COG0243	molybdopterin cofactor binding
AMK58_RS08780	COG2070	2-Nitropropane dioxygenase
AMK58_RS08785	COG3706	GGDEF domain
AMK58_RS08800	COG1410	methionine synthase
AMK58_RS08800	COG0646	methionine synthase
AMK58_RS08820	COG2853	Lipoprotein
AMK58_RS08835	COG0488	(ABC) transporter
AMK58_RS08840	COG1671	Belongs to the UPF0178 family
AMK58_RS08845	COG5002	protein histidine kinase activity
AMK58_RS08845	COG2176	DNA-directed DNA polymerase activity
AMK58_RS08870	COG1640	4-alpha-glucanotransferase
AMK58_RS08875	COG0745	RESPONSE REGULATOR receiver
AMK58_RS08885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMK58_RS08890	COG0366	Alpha amylase catalytic
AMK58_RS08905	COG1218	3'(2'),5'-bisphosphate nucleotidase
AMK58_RS08910	COG2833	Protein of unknown function (DUF455)
AMK58_RS08925	COG1960	acyl-CoA dehydrogenase activity
AMK58_RS08930	COG1028	Short-chain dehydrogenase reductase Sdr
AMK58_RS08935	COG0318	PFAM AMP-dependent synthetase and ligase
AMK58_RS08940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMK58_RS08945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMK58_RS08990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMK58_RS09000	COG1846	Transcriptional regulator
AMK58_RS09005	COG2267	carboxylic ester hydrolase activity
AMK58_RS09020	COG2226	methyltransferase
AMK58_RS09035	COG1201	RNA secondary structure unwinding
AMK58_RS09045	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AMK58_RS09050	COG0415	Belongs to the DNA photolyase family
AMK58_RS09060	COG0735	belongs to the Fur family
AMK58_RS09065	COG0523	cobalamin synthesis protein
AMK58_RS09075	COG0463	Glycosyl transferase, family 2
AMK58_RS09080	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AMK58_RS09085	COG1234	tRNA 3'-trailer cleavage
AMK58_RS09095	COG0840	transmembrane signaling receptor activity
AMK58_RS09100	COG0840	transmembrane signaling receptor activity
AMK58_RS09115	COG4520	surface antigen
AMK58_RS09120	COG0484	heat shock protein binding
AMK58_RS09145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMK58_RS09145	COG4191	Histidine kinase
AMK58_RS09160	COG0784	Response regulator, receiver
AMK58_RS09160	COG3437	response regulator, receiver
AMK58_RS09185	COG2076	Multidrug Resistance protein
AMK58_RS09190	COG0300	oxidoreductase activity
AMK58_RS09195	COG1765	OsmC-like protein
AMK58_RS09205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AMK58_RS09215	COG0697	spore germination
AMK58_RS09220	COG0367	asparagine synthase
AMK58_RS09235	COG0438	transferase activity, transferring glycosyl groups
AMK58_RS09240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMK58_RS09250	COG1086	Polysaccharide biosynthesis protein
AMK58_RS09260	COG2885	chlorophyll binding
AMK58_RS09275	COG0848	biopolymer transport protein
AMK58_RS09285	COG0824	Thioesterase
AMK58_RS09290	COG2255	four-way junction helicase activity
AMK58_RS09305	COG0217	transcriptional regulatory protein
AMK58_RS09310	COG1692	metallophosphoesterase
AMK58_RS09315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AMK58_RS09360	COG1830	Aldolase
AMK58_RS09365	COG0352	thiamine-phosphate diphosphorylase activity
AMK58_RS09370	COG0730	response to heat
AMK58_RS09375	COG2067	long-chain fatty acid transport protein
AMK58_RS09380	COG0604	alcohol dehydrogenase
AMK58_RS09385	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AMK58_RS09390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMK58_RS09395	COG0483	inositol monophosphate 1-phosphatase activity
AMK58_RS09415	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMK58_RS09420	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMK58_RS09425	COG0509	glycine decarboxylation via glycine cleavage system
AMK58_RS09430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AMK58_RS09445	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMK58_RS09450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AMK58_RS09460	COG0318	PFAM AMP-dependent synthetase and ligase
AMK58_RS09465	COG0678	peroxiredoxin activity
AMK58_RS09470	COG4232	protein-disulfide reductase activity
AMK58_RS09475	COG1678	Uncharacterized ACR, COG1678
AMK58_RS09485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMK58_RS09490	COG0612	Peptidase, M16
AMK58_RS09500	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMK58_RS09505	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AMK58_RS09510	COG3346	SURF1 family
AMK58_RS09530	COG0109	protoheme IX farnesyltransferase activity
AMK58_RS09535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMK58_RS09540	COG1565	acr, cog1565
AMK58_RS09540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AMK58_RS09550	COG0312	modulator of DNA gyrase
AMK58_RS09555	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AMK58_RS09560	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMK58_RS09570	COG5487	UPF0391 membrane protein
AMK58_RS09580	COG0741	lytic transglycosylase activity
AMK58_RS09610	COG0564	pseudouridine synthase activity
AMK58_RS09625	COG0515	serine threonine protein kinase
AMK58_RS09625	COG3266	domain, Protein
AMK58_RS09630	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AMK58_RS09635	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AMK58_RS09645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AMK58_RS09660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AMK58_RS09665	COG1295	ribonuclease BN
AMK58_RS09670	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AMK58_RS09680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AMK58_RS09690	COG0745	RESPONSE REGULATOR receiver
AMK58_RS09700	COG0616	signal peptide processing
AMK58_RS09715	COG0784	Response regulator, receiver
AMK58_RS09715	COG2198	Histidine kinase
AMK58_RS09715	COG5002	protein histidine kinase activity
AMK58_RS09725	COG0390	transport system, permease component
AMK58_RS09730	COG1136	(ABC) transporter
AMK58_RS09730	COG0577	efflux transmembrane transporter activity
AMK58_RS09740	COG0628	permease
AMK58_RS09745	COG2205	protein histidine kinase activity
AMK58_RS09755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMK58_RS09765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMK58_RS09770	COG0251	oxidation-reduction process
AMK58_RS09780	COG0551	DNA topoisomerase type I activity
AMK58_RS09780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMK58_RS09810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AMK58_RS09820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AMK58_RS09840	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AMK58_RS09840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AMK58_RS09850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMK58_RS09865	COG0505	Belongs to the CarA family
AMK58_RS09875	COG1403	HNH endonuclease
AMK58_RS09885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMK58_RS09890	COG1393	Belongs to the ArsC family
AMK58_RS09895	COG2890	protein-(glutamine-N5) methyltransferase activity
AMK58_RS09900	COG0456	acetyltransferase
AMK58_RS09900	COG1214	PFAM Peptidase M22, glycoprotease
AMK58_RS09940	COG0538	isocitrate dehydrogenase activity
AMK58_RS09950	COG3932	Exopolysaccharide synthesis, ExoD
AMK58_RS09970	COG0473	3-isopropylmalate dehydrogenase activity
AMK58_RS10000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMK58_RS10020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMK58_RS10035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMK58_RS10055	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AMK58_RS10060	COG1684	flagellar biosynthetic protein fliR
AMK58_RS10065	COG1987	bacterial-type flagellum assembly
AMK58_RS10070	COG1677	Flagellar hook-basal body complex protein FliE
AMK58_RS10075	COG1558	bacterial-type flagellum-dependent cell motility
AMK58_RS10080	COG1815	bacterial-type flagellum-dependent cell motility
AMK58_RS10085	COG2257	FlhB HrpN YscU SpaS Family
AMK58_RS10100	COG1338	Plays a role in the flagellum-specific transport system
AMK58_RS10115	COG1360	Flagellar Motor Protein
AMK58_RS10155	COG4786	Flagellar basal body rod
AMK58_RS10160	COG4786	Flagellar basal body rod
AMK58_RS10170	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AMK58_RS10210	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AMK58_RS10235	COG0500	methyltransferase
AMK58_RS10245	COG1132	(ABC) transporter
AMK58_RS10250	COG0254	rRNA binding
AMK58_RS10260	COG0071	Belongs to the small heat shock protein (HSP20) family
AMK58_RS10280	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMK58_RS10295	COG2186	Transcriptional regulator
AMK58_RS10300	COG0563	adenylate kinase activity
AMK58_RS10305	COG0201	protein transport
AMK58_RS10310	COG0200	Binds to the 23S rRNA
AMK58_RS10315	COG1841	ribosomal large subunit assembly
AMK58_RS10330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AMK58_RS10335	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AMK58_RS10340	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AMK58_RS10350	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AMK58_RS10360	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AMK58_RS10365	COG0255	Belongs to the universal ribosomal protein uL29 family
AMK58_RS10370	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AMK58_RS10375	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AMK58_RS10380	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AMK58_RS10385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AMK58_RS10390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AMK58_RS10395	COG0089	rRNA binding
AMK58_RS10400	COG0088	Forms part of the polypeptide exit tunnel
AMK58_RS10410	COG0051	transcription antitermination factor activity, RNA binding
AMK58_RS10415	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMK58_RS10425	COG0049	tRNA binding
AMK58_RS10440	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AMK58_RS10445	COG0085	RNA polymerase activity
AMK58_RS10450	COG0222	ribosome binding
AMK58_RS10455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AMK58_RS10460	COG0081	regulation of translation
AMK58_RS10465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMK58_RS10485	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMK58_RS10565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AMK58_RS10575	COG1940	carbohydrate kinase activity
AMK58_RS10590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMK58_RS10600	COG0411	ABC transporter
AMK58_RS10630	COG0673	inositol 2-dehydrogenase activity
AMK58_RS10640	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AMK58_RS10650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMK58_RS10655	COG1309	transcriptional regulator
AMK58_RS10665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMK58_RS10685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMK58_RS10725	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AMK58_RS10730	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMK58_RS10735	COG1530	ribonuclease E activity
AMK58_RS10765	COG0436	Aminotransferase
AMK58_RS10775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AMK58_RS10790	COG2264	protein methyltransferase activity
AMK58_RS10800	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AMK58_RS10815	COG0312	modulator of DNA gyrase
AMK58_RS10825	COG1597	lipid kinase activity
AMK58_RS10835	COG0438	transferase activity, transferring glycosyl groups
AMK58_RS10845	COG1519	Transferase
AMK58_RS10850	COG1663	tetraacyldisaccharide 4'-kinase activity
AMK58_RS10885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMK58_RS10895	COG0590	tRNA wobble adenosine to inosine editing
AMK58_RS10920	COG2703	oxygen carrier activity
AMK58_RS10925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMK58_RS10950	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AMK58_RS10960	COG2030	dehydratase
AMK58_RS10965	COG0196	riboflavin kinase activity
AMK58_RS10970	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AMK58_RS10975	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AMK58_RS10980	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AMK58_RS10990	COG0612	Peptidase, M16
AMK58_RS10995	COG0612	Peptidase, M16
AMK58_RS11005	COG0166	Belongs to the GPI family
AMK58_RS11025	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AMK58_RS11045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMK58_RS11060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMK58_RS11085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMK58_RS11090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMK58_RS11115	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMK58_RS11120	COG2188	Transcriptional regulator
AMK58_RS11125	COG0667	Aldo Keto reductase
AMK58_RS11150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMK58_RS11155	COG1028	Short-chain dehydrogenase reductase Sdr
AMK58_RS11190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMK58_RS11200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMK58_RS11205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMK58_RS11235	COG1309	transcriptional regulator
AMK58_RS11245	COG1518	maintenance of DNA repeat elements
AMK58_RS11285	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMK58_RS11300	COG0742	ribosomal rna small subunit methyltransferase
AMK58_RS11305	COG1187	pseudouridine synthase activity
AMK58_RS11310	COG3360	Dodecin
AMK58_RS11315	COG0590	tRNA wobble adenosine to inosine editing
AMK58_RS11330	COG1570	exodeoxyribonuclease VII activity
AMK58_RS11340	COG0418	dihydroorotase activity
AMK58_RS11345	COG0124	histidyl-tRNA synthetase
AMK58_RS11385	COG1546	Belongs to the CinA family
AMK58_RS11385	COG1058	Belongs to the CinA family
AMK58_RS11390	COG1489	DNA binding
AMK58_RS11395	COG0024	Methionine aminopeptidase
AMK58_RS11415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AMK58_RS11430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMK58_RS11435	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMK58_RS11445	COG2258	MOSC domain
AMK58_RS11455	COG0583	DNA-binding transcription factor activity
AMK58_RS11460	COG0047	phosphoribosylformylglycinamidine synthase activity
AMK58_RS11465	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMK58_RS11475	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AMK58_RS11485	COG2962	Rard protein
AMK58_RS11495	COG1902	pentaerythritol trinitrate reductase activity
AMK58_RS11500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AMK58_RS11515	COG3279	Response regulator of the LytR AlgR family
AMK58_RS11525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMK58_RS11535	COG2205	protein histidine kinase activity
AMK58_RS11575	COG0723	plastoquinol--plastocyanin reductase activity
AMK58_RS11590	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMK58_RS11600	COG0463	Glycosyl transferase, family 2
AMK58_RS11625	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AMK58_RS11665	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AMK58_RS11675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AMK58_RS11685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMK58_RS11705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMK58_RS11705	COG2010	Cytochrome c
AMK58_RS11720	COG0799	negative regulation of ribosome biogenesis
AMK58_RS11725	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AMK58_RS11730	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AMK58_RS11740	COG0793	Belongs to the peptidase S41A family
AMK58_RS11750	COG1051	belongs to the nudix hydrolase family
AMK58_RS11770	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AMK58_RS11780	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMK58_RS11800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AMK58_RS11810	COG4974	Belongs to the 'phage' integrase family
AMK58_RS11815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMK58_RS11825	COG0596	Alpha beta hydrolase
AMK58_RS11845	COG4191	Histidine kinase
AMK58_RS11855	COG4106	trans-aconitate 2-methyltransferase activity
AMK58_RS11875	COG2226	methyltransferase
AMK58_RS11880	COG0126	phosphoglycerate kinase activity
AMK58_RS11890	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AMK58_RS11905	COG3474	cytochrome
AMK58_RS11910	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AMK58_RS11940	COG4166	transmembrane transport
AMK58_RS11950	COG4166	transmembrane transport
AMK58_RS11955	COG4174	ABC transporter (Permease)
AMK58_RS11960	COG4239	(ABC) transporter, permease
AMK58_RS11965	COG4172	Belongs to the ABC transporter superfamily
AMK58_RS12000	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AMK58_RS12005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMK58_RS12015	COG2358	TRAP transporter, solute receptor (TAXI family
AMK58_RS12035	COG0587	DNA-directed DNA polymerase activity
AMK58_RS12065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMK58_RS12070	COG0625	glutathione transferase activity
AMK58_RS12080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMK58_RS12085	COG0601	transmembrane transport
AMK58_RS12110	COG0583	DNA-binding transcription factor activity
AMK58_RS12125	COG5001	Diguanylate cyclase
AMK58_RS12130	COG0625	glutathione transferase activity
AMK58_RS12135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMK58_RS12145	COG0156	8-amino-7-oxononanoate synthase activity
AMK58_RS12160	COG1028	Short-chain dehydrogenase reductase Sdr
AMK58_RS12175	COG1322	Protein conserved in bacteria
AMK58_RS12180	COG1278	Cold shock
AMK58_RS12190	COG0242	peptide deformylase activity
AMK58_RS12195	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AMK58_RS12200	COG0101	tRNA pseudouridine synthase activity
AMK58_RS12220	COG2378	regulation of single-species biofilm formation
AMK58_RS12225	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMK58_RS12240	COG0335	large ribosomal subunit rRNA binding
AMK58_RS12250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AMK58_RS12255	COG0228	four-way junction DNA binding
AMK58_RS12260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AMK58_RS12300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMK58_RS12315	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AMK58_RS12330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMK58_RS12340	COG1131	(ABC) transporter
AMK58_RS12350	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AMK58_RS12365	COG0489	protein tyrosine kinase activity
AMK58_RS12365	COG3206	protein involved in exopolysaccharide biosynthesis
AMK58_RS12375	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AMK58_RS12385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMK58_RS12430	COG1215	transferase activity, transferring glycosyl groups
AMK58_RS12440	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AMK58_RS12450	COG0706	membrane insertase activity
AMK58_RS12455	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AMK58_RS12470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AMK58_RS12480	COG0598	Magnesium transport protein CorA
AMK58_RS12495	COG0825	malonyl-CoA metabolic process
AMK58_RS12505	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AMK58_RS12510	COG4974	Belongs to the 'phage' integrase family
AMK58_RS12530	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AMK58_RS12535	COG0517	IMP dehydrogenase activity
AMK58_RS12550	COG0271	Belongs to the BolA IbaG family
AMK58_RS12580	COG1840	ABC-type Fe3 transport system, periplasmic component
AMK58_RS12585	COG1741	Belongs to the pirin family
AMK58_RS12590	COG1178	ABC-type Fe3 transport system permease component
AMK58_RS12595	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AMK58_RS12605	COG0135	phosphoribosylanthranilate isomerase activity
AMK58_RS12625	COG2423	ornithine cyclodeaminase activity
AMK58_RS12635	COG0776	regulation of translation
AMK58_RS12645	COG0539	negative regulation of cytoplasmic translation
AMK58_RS12660	COG0405	Gamma-glutamyltransferase
AMK58_RS12680	COG1741	Belongs to the pirin family
AMK58_RS12700	COG5002	protein histidine kinase activity
AMK58_RS12700	COG2205	protein histidine kinase activity
AMK58_RS12700	COG0784	Response regulator, receiver
AMK58_RS12715	COG0463	Glycosyl transferase, family 2
AMK58_RS12725	COG0071	Belongs to the small heat shock protein (HSP20) family
AMK58_RS12755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AMK58_RS12780	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AMK58_RS12805	COG3162	membrane
AMK58_RS12820	COG1971	Probably functions as a manganese efflux pump
AMK58_RS12825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMK58_RS12830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AMK58_RS12835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AMK58_RS12840	COG1987	bacterial-type flagellum assembly
AMK58_RS12845	COG4106	trans-aconitate 2-methyltransferase activity
AMK58_RS12865	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMK58_RS12870	COG0513	Belongs to the DEAD box helicase family
AMK58_RS12875	COG1970	mechanosensitive ion channel activity
AMK58_RS12880	COG0653	protein targeting
AMK58_RS12885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMK58_RS12890	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AMK58_RS12900	COG0494	nUDIX hydrolase
AMK58_RS12905	COG0514	ATP-dependent DNA helicase (RecQ)
AMK58_RS12935	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMK58_RS12940	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMK58_RS12970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMK58_RS12980	COG0412	Dienelactone hydrolase
AMK58_RS12985	COG0033	Phosphoglucomutase
AMK58_RS12990	COG1278	Cold shock
AMK58_RS13030	COG0444	Belongs to the ABC transporter superfamily
AMK58_RS13035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMK58_RS13040	COG0601	transmembrane transport
AMK58_RS13045	COG0747	negative chemotaxis
AMK58_RS13105	COG0671	phosphoesterase, PA-phosphatase related
AMK58_RS13115	COG0784	Response regulator, receiver
AMK58_RS13115	COG3437	response regulator, receiver
AMK58_RS13130	COG1983	PspC domain protein
AMK58_RS13140	COG1842	Phage shock protein A
AMK58_RS13145	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AMK58_RS13155	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AMK58_RS13170	COG3005	denitrification pathway
AMK58_RS13175	COG1858	cytochrome C peroxidase
AMK58_RS13180	COG0753	catalase activity
AMK58_RS13185	COG0459	protein refolding
AMK58_RS13190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AMK58_RS13195	COG5425	PFAM Usg family protein
AMK58_RS13200	COG3772	lysozyme
AMK58_RS13205	COG0493	'glutamate synthase
AMK58_RS13205	COG0543	2 iron, 2 sulfur cluster binding
AMK58_RS13210	COG1612	heme a metabolic process
AMK58_RS13235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMK58_RS13245	COG0668	transmembrane transport
AMK58_RS13250	COG3437	response regulator, receiver
AMK58_RS13250	COG0784	Response regulator, receiver
AMK58_RS13255	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AMK58_RS13270	COG3800	Transcriptional regulator
AMK58_RS13270	COG1396	sequence-specific DNA binding
AMK58_RS13275	COG2224	Isocitrate lyase
AMK58_RS13280	COG0693	protein deglycase activity
AMK58_RS13285	COG2205	protein histidine kinase activity
AMK58_RS13285	COG2202	Pas domain
AMK58_RS13290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AMK58_RS13295	COG0674	pyruvate-flavodoxin oxidoreductase activity
AMK58_RS13295	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AMK58_RS13300	COG1013	pyruvate-flavodoxin oxidoreductase activity
AMK58_RS13320	COG3685	Protein conserved in bacteria
AMK58_RS13335	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AMK58_RS13340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMK58_RS13350	COG0747	negative chemotaxis
AMK58_RS13360	COG0606	chelatase, subunit chli
AMK58_RS13415	COG4372	Transposase
AMK58_RS13420	COG3436	PFAM IS66 Orf2 family protein
AMK58_RS13425	COG3328	transposase activity
AMK58_RS13520	COG4372	Transposase
AMK58_RS13585	COG0464	growth
AMK58_RS13590	COG3485	protocatechuate 3,4-dioxygenase
AMK58_RS13625	COG2264	protein methyltransferase activity
AMK58_RS13675	COG0606	chelatase, subunit chli
AMK58_RS13695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMK58_RS13700	COG0347	Belongs to the P(II) protein family
AMK58_RS13705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMK58_RS13710	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AMK58_RS13715	COG0667	Aldo Keto reductase
AMK58_RS13730	COG4181	ATPase activity
AMK58_RS13740	COG3706	GGDEF domain
AMK58_RS13750	COG0443	Heat shock 70 kDa protein
AMK58_RS13785	COG1420	regulation of RNA biosynthetic process
AMK58_RS13790	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AMK58_RS13795	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AMK58_RS13800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMK58_RS13805	COG0840	transmembrane signaling receptor activity
AMK58_RS13810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AMK58_RS13835	COG0792	nuclease activity
AMK58_RS13840	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AMK58_RS13860	COG1366	Belongs to the anti-sigma-factor antagonist family
AMK58_RS13870	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AMK58_RS14420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMK58_RS14760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMK58_RS15295	COG0133	tryptophan synthase activity
AMK58_RS15620	COG4581	dead DEAH box helicase
AMK58_RS15680	COG0784	Response regulator, receiver
AMK58_RS15680	COG4191	Histidine kinase
AMK58_RS15700	COG3852	Histidine kinase
AMK58_RS16040	COG0513	Belongs to the DEAD box helicase family
AMK58_RS16165	COG5002	protein histidine kinase activity
AMK58_RS16165	COG2176	DNA-directed DNA polymerase activity
AMK58_RS16365	COG2076	Multidrug Resistance protein
AMK58_RS16715	COG3300	MHYT domain
AMK58_RS16715	COG5001	Diguanylate cyclase
AMK58_RS16805	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AMK58_RS16915	COG0714	Associated with various cellular activities
AMK58_RS17390	COG1643	Atp-dependent helicase
AMK58_RS17410	COG0745	RESPONSE REGULATOR receiver
AMK58_RS17705	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMK58_RS17815	COG2890	protein-(glutamine-N5) methyltransferase activity
AMK58_RS17850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMK58_RS17885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMK58_RS18210	COG1104	cysteine desulfurase activity
AMK58_RS18370	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AMK58_RS18530	COG0277	FAD linked oxidase domain protein
AMK58_RS18560	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AMK58_RS18900	COG0604	alcohol dehydrogenase
AMK58_RS18900	COG3321	synthase
AMK58_RS19305	COG3845	ABC transporter
AMK58_RS19485	COG4191	Histidine kinase
AMK58_RS19530	COG0564	pseudouridine synthase activity
AMK58_RS19895	COG0052	Belongs to the universal ribosomal protein uS2 family
AMK58_RS19925	COG0750	zinc metalloprotease
AMK58_RS20065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AMK58_RS20585	COG0045	succinate-CoA ligase (ADP-forming) activity
AMK58_RS20860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMK58_RS20990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMK58_RS21045	COG0741	lytic transglycosylase activity
AMK58_RS21335	COG0525	valine-tRNA ligase activity
AMK58_RS21405	COG1177	transmembrane transport
AMK58_RS21740	COG0110	maltose O-acetyltransferase activity
AMK58_RS21865	COG4172	Belongs to the ABC transporter superfamily
AMK58_RS22165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMK58_RS22345	COG2226	methyltransferase
AMK58_RS22400	COG3842	ATPase activity
AMK58_RS22565	COG0756	dUTP diphosphatase activity
AMK58_RS22580	COG2204	response regulator
AMK58_RS22740	COG0004	ammonium transporteR
AMK58_RS23305	COG2205	protein histidine kinase activity
AMK58_RS23430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMK58_RS23515	COG2902	Dehydrogenase
AMK58_RS23525	COG2902	Dehydrogenase
AMK58_RS23670	COG0784	Response regulator, receiver
AMK58_RS23670	COG3437	response regulator, receiver
AMK58_RS23735	COG2201	protein-glutamate methylesterase activity
AMK58_RS23875	COG0045	succinate-CoA ligase (ADP-forming) activity
AMK58_RS23970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AMK58_RS24240	COG0167	dihydroorotate dehydrogenase activity
AMK58_RS24505	COG2304	oxidoreductase activity
AMK58_RS25050	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AMK58_RS25070	COG0406	alpha-ribazole phosphatase activity
AMK58_RS25305	COG1331	Highly conserved protein containing a thioredoxin domain
AMK58_RS25340	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AMK58_RS25705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMK58_RS25790	COG2132	Multicopper oxidase
AMK58_RS25925	COG0756	dUTP diphosphatase activity
AMK58_RS25930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AMK58_RS25950	COG0784	Response regulator, receiver
AMK58_RS25950	COG2205	protein histidine kinase activity
AMK58_RS25950	COG5002	protein histidine kinase activity
AMK58_RS26175	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AMK58_RS26245	COG0137	argininosuccinate synthase activity
AMK58_RS26525	COG2967	ApaG domain
AMK58_RS26965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMK58_RS26970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMK58_RS27025	COG2902	Dehydrogenase
AMK58_RS27200	COG3437	response regulator, receiver
AMK58_RS27200	COG0784	Response regulator, receiver
AMK58_RS27520	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AMK58_RS27960	COG1309	transcriptional regulator
AMK58_RS28245	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AMK58_RS28290	COG0488	(ABC) transporter
AMK58_RS28490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AMK58_RS28510	COG1185	polyribonucleotide nucleotidyltransferase activity
AMK58_RS28530	COG1509	lysine 2,3-aminomutase activity
AMK58_RS28680	COG2132	Multicopper oxidase
AMK58_RS29265	COG0220	tRNA (guanine-N7-)-methyltransferase activity