locus-tag	class	description
A6A40_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6A40_RS00015	COG3706	GGDEF domain
A6A40_RS00040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6A40_RS00050	COG3842	ATPase activity
A6A40_RS00055	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6A40_RS00060	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6A40_RS00080	COG2264	protein methyltransferase activity
A6A40_RS00100	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A6A40_RS00160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6A40_RS00165	COG1120	ATPase activity
A6A40_RS00185	COG0406	alpha-ribazole phosphatase activity
A6A40_RS00195	COG1234	tRNA 3'-trailer cleavage
A6A40_RS00205	COG0745	RESPONSE REGULATOR receiver
A6A40_RS00280	COG1509	lysine 2,3-aminomutase activity
A6A40_RS00285	COG0584	glycerophosphoryl diester phosphodiesterase
A6A40_RS00310	COG2202	Pas domain
A6A40_RS00310	COG2205	protein histidine kinase activity
A6A40_RS00325	COG3162	membrane
A6A40_RS00340	COG0318	PFAM AMP-dependent synthetase and ligase
A6A40_RS00355	COG1960	acyl-CoA dehydrogenase activity
A6A40_RS00360	COG1187	pseudouridine synthase activity
A6A40_RS00370	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6A40_RS00380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6A40_RS00385	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6A40_RS00390	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6A40_RS00405	COG3437	response regulator, receiver
A6A40_RS00405	COG0784	Response regulator, receiver
A6A40_RS00415	COG0583	DNA-binding transcription factor activity
A6A40_RS00425	COG0252	asparaginase activity
A6A40_RS00440	COG0481	GTPase activity
A6A40_RS00455	COG0297	glycogen (starch) synthase activity
A6A40_RS00460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6A40_RS00465	COG0004	ammonium transporteR
A6A40_RS00470	COG1741	Belongs to the pirin family
A6A40_RS00490	COG2313	pseudouridylate synthase activity
A6A40_RS00500	COG1793	dna ligase
A6A40_RS00515	COG3660	Nucleoside-diphosphate-sugar epimerase
A6A40_RS00520	COG1522	sequence-specific DNA binding
A6A40_RS00535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6A40_RS00540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6A40_RS00555	COG3005	denitrification pathway
A6A40_RS00565	COG0243	molybdopterin cofactor binding
A6A40_RS00590	COG2205	protein histidine kinase activity
A6A40_RS00600	COG2318	DinB family
A6A40_RS00605	COG1674	ftsk spoiiie
A6A40_RS00615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6A40_RS00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6A40_RS00630	COG1238	metal cluster binding
A6A40_RS00685	COG0539	negative regulation of cytoplasmic translation
A6A40_RS00695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6A40_RS00705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6A40_RS00705	COG0574	Belongs to the PEP-utilizing enzyme family
A6A40_RS00715	COG1309	transcriptional regulator
A6A40_RS00720	COG1252	NADH dehydrogenase
A6A40_RS00735	COG0583	DNA-binding transcription factor activity
A6A40_RS00740	COG1643	Atp-dependent helicase
A6A40_RS00775	COG4191	Histidine kinase
A6A40_RS00805	COG0045	succinate-CoA ligase (ADP-forming) activity
A6A40_RS00810	COG0039	L-malate dehydrogenase activity
A6A40_RS00845	COG1970	mechanosensitive ion channel activity
A6A40_RS00850	COG0653	protein targeting
A6A40_RS00855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6A40_RS00860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A6A40_RS00865	COG0494	nUDIX hydrolase
A6A40_RS00870	COG0514	ATP-dependent DNA helicase (RecQ)
A6A40_RS00885	COG0024	Methionine aminopeptidase
A6A40_RS00890	COG1489	DNA binding
A6A40_RS00895	COG1058	Belongs to the CinA family
A6A40_RS00895	COG1546	Belongs to the CinA family
A6A40_RS00915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6A40_RS00920	COG0640	Transcriptional regulator
A6A40_RS00930	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A6A40_RS00935	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
A6A40_RS00940	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6A40_RS00945	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6A40_RS00950	COG1842	Phage shock protein A
A6A40_RS00975	COG1442	glycosyl transferase family 8
A6A40_RS00975	COG1216	Glycosyl transferase, family 2
A6A40_RS01005	COG0181	hydroxymethylbilane synthase activity
A6A40_RS01015	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6A40_RS01040	COG0587	DNA-directed DNA polymerase activity
A6A40_RS01055	COG3437	response regulator, receiver
A6A40_RS01055	COG0784	Response regulator, receiver
A6A40_RS01060	COG3158	transport of potassium into the cell
A6A40_RS01080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6A40_RS01085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6A40_RS01090	COG0842	Transport permease protein
A6A40_RS01095	COG2137	regulation of response to DNA damage stimulus
A6A40_RS01100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6A40_RS01110	COG1703	isobutyryl-CoA mutase activity
A6A40_RS01115	COG4172	Belongs to the ABC transporter superfamily
A6A40_RS01120	COG4239	(ABC) transporter, permease
A6A40_RS01125	COG4174	ABC transporter (Permease)
A6A40_RS01130	COG4166	transmembrane transport
A6A40_RS01135	COG4166	transmembrane transport
A6A40_RS01165	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6A40_RS01170	COG3474	cytochrome
A6A40_RS01185	COG2766	serine protein kinase
A6A40_RS01190	COG2718	Belongs to the UPF0229 family
A6A40_RS01195	COG2719	SpoVR family
A6A40_RS01210	COG0318	PFAM AMP-dependent synthetase and ligase
A6A40_RS01215	COG1254	Belongs to the acylphosphatase family
A6A40_RS01250	COG2239	Acts as a magnesium transporter
A6A40_RS01265	COG2022	thiamine diphosphate biosynthetic process
A6A40_RS01275	COG2022	thiamine diphosphate biosynthetic process
A6A40_RS01275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6A40_RS01280	COG0840	transmembrane signaling receptor activity
A6A40_RS01355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6A40_RS01360	COG3108	Peptidase M15
A6A40_RS01365	COG2003	Belongs to the UPF0758 family
A6A40_RS01370	COG3038	cytochrome b561
A6A40_RS01375	COG0642	Histidine kinase
A6A40_RS01380	COG0745	RESPONSE REGULATOR receiver
A6A40_RS01385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6A40_RS01390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6A40_RS01405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6A40_RS01410	COG0277	FAD linked oxidase domain protein
A6A40_RS01415	COG0277	FAD linked oxidase domain protein
A6A40_RS01420	COG0247	lactate metabolic process
A6A40_RS01440	COG1454	alcohol dehydrogenase
A6A40_RS01450	COG1960	acyl-CoA dehydrogenase activity
A6A40_RS01470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6A40_RS01480	COG2171	N-acyltransferase activity
A6A40_RS01515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6A40_RS01520	COG0228	four-way junction DNA binding
A6A40_RS01525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6A40_RS01530	COG0336	Belongs to the RNA methyltransferase TrmD family
A6A40_RS01535	COG0335	large ribosomal subunit rRNA binding
A6A40_RS01540	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6A40_RS01550	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A6A40_RS01555	COG0706	membrane insertase activity
A6A40_RS01560	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6A40_RS01570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6A40_RS01580	COG0598	Magnesium transport protein CorA
A6A40_RS01585	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6A40_RS01595	COG1530	ribonuclease E activity
A6A40_RS01635	COG0561	phosphatase activity
A6A40_RS01635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6A40_RS01645	COG1940	carbohydrate kinase activity
A6A40_RS01675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6A40_RS01680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6A40_RS01765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6A40_RS01785	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6A40_RS01790	COG0081	regulation of translation
A6A40_RS01795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6A40_RS01800	COG0222	ribosome binding
A6A40_RS01805	COG0085	RNA polymerase activity
A6A40_RS01810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6A40_RS01825	COG0049	tRNA binding
A6A40_RS01835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6A40_RS01840	COG0051	transcription antitermination factor activity, RNA binding
A6A40_RS01850	COG0088	Forms part of the polypeptide exit tunnel
A6A40_RS01855	COG0089	rRNA binding
A6A40_RS01860	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6A40_RS01865	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6A40_RS01870	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6A40_RS01875	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6A40_RS01880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6A40_RS01885	COG0255	Belongs to the universal ribosomal protein uL29 family
A6A40_RS01890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6A40_RS01900	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6A40_RS01910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6A40_RS01915	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6A40_RS01920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6A40_RS01930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6A40_RS01935	COG1841	ribosomal large subunit assembly
A6A40_RS01940	COG0200	Binds to the 23S rRNA
A6A40_RS01945	COG0201	protein transport
A6A40_RS01950	COG0563	adenylate kinase activity
A6A40_RS01960	COG0697	spore germination
A6A40_RS01975	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A6A40_RS01980	COG2873	o-acetylhomoserine
A6A40_RS01985	COG2226	methyltransferase
A6A40_RS01985	COG1073	alpha beta
A6A40_RS01990	COG2205	protein histidine kinase activity
A6A40_RS01995	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6A40_RS02040	COG1285	pathogenesis
A6A40_RS02045	COG2814	Major facilitator Superfamily
A6A40_RS02050	COG0196	riboflavin kinase activity
A6A40_RS02055	COG2030	dehydratase
A6A40_RS02060	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6A40_RS02075	COG0628	permease
A6A40_RS02105	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6A40_RS02110	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6A40_RS02120	COG1597	lipid kinase activity
A6A40_RS02130	COG0438	transferase activity, transferring glycosyl groups
A6A40_RS02140	COG1280	lysine exporter protein (LysE YggA)
A6A40_RS02155	COG1519	Transferase
A6A40_RS02160	COG1663	tetraacyldisaccharide 4'-kinase activity
A6A40_RS02190	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A6A40_RS02195	COG0644	oxidoreductase
A6A40_RS02250	COG1902	pentaerythritol trinitrate reductase activity
A6A40_RS02260	COG2962	Rard protein
A6A40_RS02265	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6A40_RS02275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6A40_RS02320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6A40_RS02375	COG2205	protein histidine kinase activity
A6A40_RS02390	COG0395	ABC-type sugar transport system, permease component
A6A40_RS02400	COG5508	conserved small protein
A6A40_RS02405	COG0501	Belongs to the peptidase M48B family
A6A40_RS02450	COG1366	Belongs to the anti-sigma-factor antagonist family
A6A40_RS02475	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6A40_RS02500	COG1686	Belongs to the peptidase S11 family
A6A40_RS02515	COG2202	Pas domain
A6A40_RS02515	COG2205	protein histidine kinase activity
A6A40_RS02520	COG4191	Histidine kinase
A6A40_RS02525	COG2205	protein histidine kinase activity
A6A40_RS02535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6A40_RS02550	COG0166	Belongs to the GPI family
A6A40_RS02555	COG0612	Peptidase, M16
A6A40_RS02560	COG0612	Peptidase, M16
A6A40_RS02605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6A40_RS02615	COG0840	transmembrane signaling receptor activity
A6A40_RS02625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6A40_RS02640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6A40_RS02645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6A40_RS02665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6A40_RS02670	COG0746	molybdenum cofactor guanylyltransferase activity
A6A40_RS02695	COG3383	formate dehydrogenase (NAD+) activity
A6A40_RS02695	COG0243	molybdopterin cofactor binding
A6A40_RS02700	COG0437	4 iron, 4 sulfur cluster binding
A6A40_RS02715	COG0235	Class ii aldolase
A6A40_RS02720	COG0784	Response regulator, receiver
A6A40_RS02720	COG5002	protein histidine kinase activity
A6A40_RS02725	COG3384	dioxygenase
A6A40_RS02730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6A40_RS02735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6A40_RS02740	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6A40_RS02745	COG0356	it plays a direct role in the translocation of protons across the membrane
A6A40_RS02755	COG1999	signal sequence binding
A6A40_RS02765	COG1702	phosphate starvation-inducible protein PhoH
A6A40_RS02770	COG0850	regulation of cytokinetic process
A6A40_RS02775	COG2894	cell division
A6A40_RS02780	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A6A40_RS02805	COG4948	Mandelate Racemase Muconate Lactonizing
A6A40_RS02810	COG2154	pterin-4-alpha-carbinolamine dehydratase
A6A40_RS02815	COG1573	uracil-dna glycosylase
A6A40_RS02830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6A40_RS02840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6A40_RS02850	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
A6A40_RS02855	COG5420	small protein containing a coiled-coil domain
A6A40_RS02870	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A6A40_RS02875	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A6A40_RS02935	COG0121	glutamine amidotransferase
A6A40_RS02945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6A40_RS02950	COG0552	protein localization to endoplasmic reticulum
A6A40_RS02955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6A40_RS02960	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6A40_RS03000	COG2301	Belongs to the HpcH HpaI aldolase family
A6A40_RS03005	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A6A40_RS03010	COG2205	protein histidine kinase activity
A6A40_RS03015	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6A40_RS03020	COG0840	transmembrane signaling receptor activity
A6A40_RS03020	COG2972	Histidine kinase
A6A40_RS03025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6A40_RS03030	COG1063	alcohol dehydrogenase
A6A40_RS03040	COG0596	Alpha beta hydrolase
A6A40_RS03040	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6A40_RS03045	COG0022	dehydrogenase e1 component
A6A40_RS03050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6A40_RS03055	COG3199	ATP-NAD kinase
A6A40_RS03060	COG0277	FAD linked oxidase domain protein
A6A40_RS03075	COG1671	Belongs to the UPF0178 family
A6A40_RS03080	COG0488	(ABC) transporter
A6A40_RS03110	COG2853	Lipoprotein
A6A40_RS03120	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6A40_RS03125	COG0646	methionine synthase
A6A40_RS03125	COG1410	methionine synthase
A6A40_RS03150	COG3706	GGDEF domain
A6A40_RS03160	COG2814	Major facilitator Superfamily
A6A40_RS03170	COG0175	sulfate reduction
A6A40_RS03175	COG0175	sulfate reduction
A6A40_RS03180	COG1648	precorrin-2 dehydrogenase activity
A6A40_RS03180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6A40_RS03190	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6A40_RS03200	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6A40_RS03205	COG3108	Peptidase M15
A6A40_RS03215	COG2205	protein histidine kinase activity
A6A40_RS03215	COG2202	Pas domain
A6A40_RS03220	COG4566	intracellular signal transduction
A6A40_RS03245	COG0243	molybdopterin cofactor binding
A6A40_RS03250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6A40_RS03250	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A6A40_RS03260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6A40_RS03265	COG0840	transmembrane signaling receptor activity
A6A40_RS03275	COG0612	Peptidase, M16
A6A40_RS03280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6A40_RS03300	COG0483	inositol monophosphate 1-phosphatase activity
A6A40_RS03305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6A40_RS03320	COG0730	response to heat
A6A40_RS03325	COG0352	thiamine-phosphate diphosphorylase activity
A6A40_RS03380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6A40_RS03385	COG1692	metallophosphoesterase
A6A40_RS03390	COG0217	transcriptional regulatory protein
A6A40_RS03400	COG0632	four-way junction helicase activity
A6A40_RS03405	COG2255	four-way junction helicase activity
A6A40_RS03410	COG0824	Thioesterase
A6A40_RS03420	COG0848	biopolymer transport protein
A6A40_RS03435	COG2885	chlorophyll binding
A6A40_RS03445	COG0037	tRNA processing
A6A40_RS03450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6A40_RS03460	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6A40_RS03465	COG1295	ribonuclease BN
A6A40_RS03470	COG3152	Membrane
A6A40_RS03480	COG4520	surface antigen
A6A40_RS03485	COG0259	pyridoxamine-phosphate oxidase activity
A6A40_RS03500	COG1234	tRNA 3'-trailer cleavage
A6A40_RS03505	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6A40_RS03510	COG3437	response regulator, receiver
A6A40_RS03510	COG2770	Histidine kinase
A6A40_RS03515	COG0409	Hydrogenase expression formation protein
A6A40_RS03530	COG2153	protein acetylation
A6A40_RS03560	COG4957	zinc ion binding
A6A40_RS03565	COG0698	ribose 5-phosphate isomerase
A6A40_RS03570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6A40_RS03575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6A40_RS03580	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A6A40_RS03595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6A40_RS03605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6A40_RS03605	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6A40_RS03615	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6A40_RS03615	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6A40_RS03635	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6A40_RS03640	COG0416	fatty acid biosynthetic process
A6A40_RS03645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6A40_RS03695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6A40_RS03705	COG1764	response to oxidative stress
A6A40_RS03710	COG1846	Transcriptional regulator
A6A40_RS03715	COG0456	acetyltransferase
A6A40_RS03725	COG2890	protein-(glutamine-N5) methyltransferase activity
A6A40_RS03730	COG1393	Belongs to the ArsC family
A6A40_RS03735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6A40_RS03745	COG1403	HNH endonuclease
A6A40_RS03755	COG1610	YqeY-like protein
A6A40_RS03765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6A40_RS03810	COG5489	Protein of unknown function (DUF736)
A6A40_RS03820	COG1396	sequence-specific DNA binding
A6A40_RS03970	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A6A40_RS04015	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6A40_RS04035	COG0726	polysaccharide deacetylase
A6A40_RS04040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6A40_RS04050	COG3108	Peptidase M15
A6A40_RS04055	COG1396	sequence-specific DNA binding
A6A40_RS04075	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6A40_RS04080	COG0511	ligase activity, forming carbon-carbon bonds
A6A40_RS04085	COG0439	Biotin carboxylase
A6A40_RS04090	COG0840	transmembrane signaling receptor activity
A6A40_RS04095	COG4251	negative regulation of phosphorylation
A6A40_RS04100	COG4251	negative regulation of phosphorylation
A6A40_RS04105	COG0784	Response regulator, receiver
A6A40_RS04115	COG3437	response regulator, receiver
A6A40_RS04115	COG2205	protein histidine kinase activity
A6A40_RS04115	COG3850	Histidine kinase
A6A40_RS04115	COG4999	Histidine kinase
A6A40_RS04120	COG0745	RESPONSE REGULATOR receiver
A6A40_RS04140	COG0432	Pfam Uncharacterised protein family UPF0047
A6A40_RS04155	COG2205	protein histidine kinase activity
A6A40_RS04160	COG0628	permease
A6A40_RS04170	COG0105	UTP biosynthetic process
A6A40_RS04190	COG0745	RESPONSE REGULATOR receiver
A6A40_RS04205	COG2815	serine threonine protein kinase
A6A40_RS04205	COG0515	serine threonine protein kinase
A6A40_RS04230	COG0500	methyltransferase
A6A40_RS04350	COG2208	phosphoserine phosphatase activity
A6A40_RS04350	COG2770	Histidine kinase
A6A40_RS04355	COG1366	Belongs to the anti-sigma-factor antagonist family
A6A40_RS04370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6A40_RS04375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6A40_RS04380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6A40_RS04390	COG3237	CsbD-like
A6A40_RS04405	COG1742	UPF0060 membrane protein
A6A40_RS04415	COG5001	Diguanylate cyclase
A6A40_RS04415	COG3300	MHYT domain
A6A40_RS04420	COG1840	ABC-type Fe3 transport system, periplasmic component
A6A40_RS04425	COG3842	ATPase activity
A6A40_RS04430	COG1132	(ABC) transporter
A6A40_RS04435	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6A40_RS04455	COG1178	ABC-type Fe3 transport system permease component
A6A40_RS04460	COG1217	gtp-binding protein TYPA
A6A40_RS04500	COG1561	YicC-like family, N-terminal region
A6A40_RS04515	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6A40_RS04520	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6A40_RS04525	COG0052	Belongs to the universal ribosomal protein uS2 family
A6A40_RS04530	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6A40_RS04535	COG0528	UMP kinase activity
A6A40_RS04540	COG0233	cytoplasmic translational termination
A6A40_RS04545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6A40_RS04555	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6A40_RS04560	COG0750	zinc metalloprotease
A6A40_RS04580	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6A40_RS04585	COG3494	Protein of unknown function (DUF1009)
A6A40_RS04590	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6A40_RS04600	COG4977	sequence-specific DNA binding
A6A40_RS04615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6A40_RS04620	COG0658	competence protein
A6A40_RS04620	COG2333	competence protein COMEC
A6A40_RS04625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6A40_RS04630	COG0303	'Molybdopterin
A6A40_RS04635	COG0315	cyclic pyranopterin monophosphate synthase activity
A6A40_RS04685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6A40_RS04690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6A40_RS04695	COG2813	Specifically methylates the guanine in position
A6A40_RS04700	COG0667	Aldo Keto reductase
A6A40_RS04715	COG1881	PFAM PEBP family protein
A6A40_RS04720	COG0113	porphobilinogen synthase activity
A6A40_RS04725	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A6A40_RS04730	COG1597	lipid kinase activity
A6A40_RS04735	COG1024	Enoyl-CoA hydratase
A6A40_RS04740	COG1846	Transcriptional regulator
A6A40_RS04755	COG0559	Belongs to the binding-protein-dependent transport system permease family
A6A40_RS04770	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6A40_RS04780	COG2226	methyltransferase
A6A40_RS04795	COG1028	Short-chain dehydrogenase reductase Sdr
A6A40_RS04810	COG0058	SHG alpha-glucan phosphorylase activity
A6A40_RS04815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6A40_RS04825	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A6A40_RS04835	COG2204	response regulator
A6A40_RS04840	COG1305	Transglutaminase-like
A6A40_RS04845	COG2307	Protein conserved in bacteria
A6A40_RS04845	COG2308	Evidence 4 Homologs of previously reported genes of
A6A40_RS04850	COG2010	Cytochrome c
A6A40_RS04870	COG1028	Short-chain dehydrogenase reductase Sdr
A6A40_RS04875	COG0583	DNA-binding transcription factor activity
A6A40_RS04935	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A6A40_RS04940	COG2814	Major facilitator Superfamily
A6A40_RS04945	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6A40_RS04955	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6A40_RS04970	COG1862	Preprotein translocase
A6A40_RS04975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6A40_RS04985	COG3737	Protein of unknown function (DUF498/DUF598)
A6A40_RS04990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6A40_RS04995	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A6A40_RS05000	COG1562	ergosterol biosynthetic process
A6A40_RS05005	COG1562	ergosterol biosynthetic process
A6A40_RS05040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6A40_RS05050	COG2062	phosphohistidine phosphatase, SixA
A6A40_RS05055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6A40_RS05060	COG0248	Ppx GppA phosphatase
A6A40_RS05085	COG0714	Associated with various cellular activities
A6A40_RS05110	COG3335	DDE superfamily endonuclease
A6A40_RS05120	COG0629	single-stranded DNA binding
A6A40_RS05150	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6A40_RS05155	COG1116	anion transmembrane transporter activity
A6A40_RS05160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6A40_RS05165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6A40_RS05175	COG0483	inositol monophosphate 1-phosphatase activity
A6A40_RS05190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6A40_RS05195	COG1923	regulation of RNA biosynthetic process
A6A40_RS05205	COG2204	response regulator
A6A40_RS05245	COG1942	4-Oxalocrotonate Tautomerase
A6A40_RS05250	COG2867	negative regulation of translational initiation
A6A40_RS05255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6A40_RS05275	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6A40_RS05280	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6A40_RS05280	COG0022	dehydrogenase e1 component
A6A40_RS05285	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6A40_RS05305	COG4149	molybdate abc transporter
A6A40_RS05310	COG0725	ABC transporter, periplasmic molybdate-binding protein
A6A40_RS05315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6A40_RS05320	COG2261	transglycosylase associated protein
A6A40_RS05335	COG2135	peptidase activity
A6A40_RS05345	COG2200	EAL domain
A6A40_RS05355	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6A40_RS05360	COG2833	Protein of unknown function (DUF455)
A6A40_RS05365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6A40_RS05370	COG0328	RNA-DNA hybrid ribonuclease activity
A6A40_RS05375	COG0678	peroxiredoxin activity
A6A40_RS05380	COG2824	Alkylphosphonate utilization operon protein PhnA
A6A40_RS05390	COG1678	Uncharacterized ACR, COG1678
A6A40_RS05395	COG0314	molybdopterin synthase activity
A6A40_RS05400	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A6A40_RS05410	COG0546	phosphoglycolate phosphatase activity
A6A40_RS05415	COG1763	Mo-molybdopterin cofactor biosynthetic process
A6A40_RS05420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6A40_RS05430	COG1028	Short-chain dehydrogenase reductase Sdr
A6A40_RS05450	COG4120	Belongs to the binding-protein-dependent transport system permease family
A6A40_RS05465	COG0672	)-iron permease
A6A40_RS05490	COG0583	DNA-binding transcription factor activity
A6A40_RS05495	COG0540	Belongs to the ATCase OTCase family
A6A40_RS05500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6A40_RS05510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6A40_RS05525	COG0776	regulation of translation
A6A40_RS05530	COG4957	zinc ion binding
A6A40_RS05565	COG0741	lytic transglycosylase activity
A6A40_RS05570	COG0556	nucleotide-excision repair
A6A40_RS05600	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6A40_RS05605	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6A40_RS05610	COG0509	glycine decarboxylation via glycine cleavage system
A6A40_RS05625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6A40_RS05630	COG1492	cobalamin metabolic process
A6A40_RS05665	COG0534	Mate efflux family protein
A6A40_RS05670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6A40_RS05675	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6A40_RS05710	COG1136	(ABC) transporter
A6A40_RS05710	COG0577	efflux transmembrane transporter activity
A6A40_RS05715	COG1136	(ABC) transporter
A6A40_RS05720	COG1566	PFAM secretion protein HlyD family protein
A6A40_RS05730	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A6A40_RS05750	COG0149	triose-phosphate isomerase activity
A6A40_RS05755	COG1846	Transcriptional regulator
A6A40_RS05765	COG0745	RESPONSE REGULATOR receiver
A6A40_RS05815	COG1216	Glycosyl transferase, family 2
A6A40_RS05820	COG1396	sequence-specific DNA binding
A6A40_RS05860	COG1846	Transcriptional regulator
A6A40_RS05865	COG1028	Short-chain dehydrogenase reductase Sdr
A6A40_RS05875	COG0628	permease
A6A40_RS05880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6A40_RS05890	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6A40_RS05895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6A40_RS05900	COG4221	oxidoreductase activity
A6A40_RS05905	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6A40_RS05920	COG0024	Methionine aminopeptidase
A6A40_RS05935	COG1160	GTP binding
A6A40_RS05950	COG2197	response regulator
A6A40_RS05960	COG0840	transmembrane signaling receptor activity
A6A40_RS05960	COG3290	protein histidine kinase activity
A6A40_RS05965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6A40_RS06020	COG1028	Short-chain dehydrogenase reductase Sdr
A6A40_RS06020	COG3321	synthase
A6A40_RS06020	COG0604	alcohol dehydrogenase
A6A40_RS06030	COG0163	prenyltransferase activity
A6A40_RS06035	COG0288	reversible hydration of carbon dioxide
A6A40_RS06060	COG0205	6-phosphofructokinase activity
A6A40_RS06075	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6A40_RS06080	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6A40_RS06085	COG5001	Diguanylate cyclase
A6A40_RS06105	COG0114	fumarate hydratase activity
A6A40_RS06140	COG2951	lytic endotransglycosylase activity
A6A40_RS06165	COG4191	Histidine kinase
A6A40_RS06180	COG3346	SURF1 family
A6A40_RS06190	COG1845	cytochrome c oxidase, subunit III
A6A40_RS06195	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A6A40_RS06205	COG0109	protoheme IX farnesyltransferase activity
A6A40_RS06210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6A40_RS06215	COG1565	acr, cog1565
A6A40_RS06215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6A40_RS06225	COG0312	modulator of DNA gyrase
A6A40_RS06255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6A40_RS06300	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6A40_RS06315	COG1677	Flagellar hook-basal body complex protein FliE
A6A40_RS06320	COG1558	bacterial-type flagellum-dependent cell motility
A6A40_RS06325	COG1815	bacterial-type flagellum-dependent cell motility
A6A40_RS06330	COG2257	FlhB HrpN YscU SpaS Family
A6A40_RS06345	COG1338	Plays a role in the flagellum-specific transport system
A6A40_RS06355	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6A40_RS06365	COG1360	Flagellar Motor Protein
A6A40_RS06380	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6A40_RS06390	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A6A40_RS06405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6A40_RS06410	COG0571	ribonuclease III activity
A6A40_RS06415	COG0681	Belongs to the peptidase S26 family
A6A40_RS06420	COG0736	holo-[acyl-carrier-protein] synthase activity
A6A40_RS06425	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6A40_RS06435	COG1758	RNA polymerase activity
A6A40_RS06445	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6A40_RS06450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6A40_RS06460	COG1247	-acetyltransferase
A6A40_RS06465	COG0519	Catalyzes the synthesis of GMP from XMP
A6A40_RS06465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6A40_RS06510	COG1914	H( )-stimulated, divalent metal cation uptake system
A6A40_RS06515	COG2900	Belongs to the SlyX family
A6A40_RS06520	COG2132	Multicopper oxidase
A6A40_RS06525	COG4953	penicillin-binding protein 1C
A6A40_RS06530	COG2373	Large extracellular alpha-helical protein
A6A40_RS06545	COG0583	DNA-binding transcription factor activity
A6A40_RS06550	COG0303	'Molybdopterin
A6A40_RS06555	COG1324	tolerance protein
A6A40_RS06575	COG1494	fructose-1,6-bisphosphatase
A6A40_RS06585	COG0436	Aminotransferase
A6A40_RS06595	COG0745	RESPONSE REGULATOR receiver
A6A40_RS06605	COG0616	signal peptide processing
A6A40_RS06610	COG0488	(ABC) transporter
A6A40_RS06615	COG3932	Exopolysaccharide synthesis, ExoD
A6A40_RS06630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6A40_RS06635	COG0525	valine-tRNA ligase activity
A6A40_RS06645	COG1538	Outer membrane efflux protein
A6A40_RS06655	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6A40_RS06690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6A40_RS06695	COG0494	nUDIX hydrolase
A6A40_RS06700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6A40_RS06705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6A40_RS06710	COG2897	thiosulfate sulfurtransferase activity
A6A40_RS06730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6A40_RS06735	COG1126	abc transporter atp-binding protein
A6A40_RS06740	COG0765	amino acid transport
A6A40_RS06745	COG4597	amino acid ABC transporter
A6A40_RS06750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6A40_RS06755	COG0626	cystathionine gamma-synthase activity
A6A40_RS06795	COG2308	Evidence 4 Homologs of previously reported genes of
A6A40_RS06800	COG1360	Flagellar Motor Protein
A6A40_RS06805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6A40_RS06825	COG0318	PFAM AMP-dependent synthetase and ligase
A6A40_RS06830	COG0789	Transcriptional regulator
A6A40_RS06860	COG2205	protein histidine kinase activity
A6A40_RS06865	COG0728	peptidoglycan biosynthetic process
A6A40_RS06880	COG1765	OsmC-like protein
A6A40_RS06885	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6A40_RS06895	COG5487	UPF0391 membrane protein
A6A40_RS06905	COG0741	lytic transglycosylase activity
A6A40_RS06920	COG2226	methyltransferase
A6A40_RS06930	COG0513	Belongs to the DEAD box helicase family
A6A40_RS06950	COG0187	DNA topoisomerase II activity
A6A40_RS06955	COG1607	acyl-coa hydrolase
A6A40_RS06965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6A40_RS06970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6A40_RS07000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6A40_RS07000	COG4191	Histidine kinase
A6A40_RS07015	COG3437	response regulator, receiver
A6A40_RS07015	COG0784	Response regulator, receiver
A6A40_RS07025	COG0140	phosphoribosyl-ATP diphosphatase activity
A6A40_RS07040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6A40_RS07055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6A40_RS07060	COG2198	Histidine kinase
A6A40_RS07060	COG0643	Histidine kinase
A6A40_RS07065	COG2201	protein-glutamate methylesterase activity
A6A40_RS07070	COG2201	protein-glutamate methylesterase activity
A6A40_RS07075	COG0835	chemotaxis
A6A40_RS07085	COG0840	transmembrane signaling receptor activity
A6A40_RS07090	COG0840	transmembrane signaling receptor activity
A6A40_RS07090	COG3290	protein histidine kinase activity
A6A40_RS07105	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6A40_RS07110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6A40_RS07125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6A40_RS07135	COG0360	Binds together with S18 to 16S ribosomal RNA
A6A40_RS07140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6A40_RS07150	COG0359	binds to the 23S rRNA
A6A40_RS07155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6A40_RS07160	COG3706	GGDEF domain
A6A40_RS07165	COG0538	isocitrate dehydrogenase activity
A6A40_RS07175	COG0330	HflC and HflK could
A6A40_RS07205	COG0473	3-isopropylmalate dehydrogenase activity
A6A40_RS07235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6A40_RS07270	COG1686	Belongs to the peptidase S11 family
A6A40_RS07275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6A40_RS07280	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6A40_RS07285	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6A40_RS07290	COG0084	hydrolase, TatD family'
A6A40_RS07295	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6A40_RS07295	COG0321	lipoyl(octanoyl) transferase activity
A6A40_RS07300	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A6A40_RS07330	COG1381	Involved in DNA repair and RecF pathway recombination
A6A40_RS07335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6A40_RS07360	COG4786	Flagellar basal body rod
A6A40_RS07365	COG4786	Flagellar basal body rod
A6A40_RS07375	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6A40_RS07430	COG1309	transcriptional regulator
A6A40_RS07440	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A6A40_RS07445	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A6A40_RS07455	COG1024	Enoyl-CoA hydratase
A6A40_RS07465	COG0758	DNA mediated transformation
A6A40_RS07470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6A40_RS07475	COG1024	Enoyl-CoA hydratase
A6A40_RS07480	COG1832	CoA-binding protein
A6A40_RS07485	COG2873	o-acetylhomoserine
A6A40_RS07495	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6A40_RS07525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6A40_RS07545	COG3447	MASE1 domain protein
A6A40_RS07545	COG5001	Diguanylate cyclase
A6A40_RS07545	COG5002	protein histidine kinase activity
A6A40_RS07565	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6A40_RS07580	COG1238	metal cluster binding
A6A40_RS07585	COG0203	ribosomal protein L17
A6A40_RS07600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6A40_RS07610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6A40_RS07615	COG0251	oxidation-reduction process
A6A40_RS07620	COG3591	Belongs to the peptidase S1B family
A6A40_RS07625	COG0551	DNA topoisomerase type I activity
A6A40_RS07625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6A40_RS07675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6A40_RS07675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6A40_RS07710	COG0154	amidase activity
A6A40_RS07715	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6A40_RS07730	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6A40_RS07740	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A6A40_RS07765	COG0242	peptide deformylase activity
A6A40_RS07775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6A40_RS07780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6A40_RS07785	COG1201	RNA secondary structure unwinding
A6A40_RS07795	COG0415	Belongs to the DNA photolyase family
A6A40_RS07800	COG0735	belongs to the Fur family
A6A40_RS07805	COG0523	cobalamin synthesis protein
A6A40_RS07815	COG0840	transmembrane signaling receptor activity
A6A40_RS07820	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A6A40_RS07835	COG2205	protein histidine kinase activity
A6A40_RS07845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6A40_RS07850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6A40_RS07850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6A40_RS07870	COG4251	negative regulation of phosphorylation
A6A40_RS07875	COG0494	nUDIX hydrolase
A6A40_RS07885	COG0497	DNA recombination
A6A40_RS07890	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6A40_RS07910	COG0006	proline dipeptidase activity
A6A40_RS07920	COG2264	protein methyltransferase activity
A6A40_RS07930	COG0210	DNA helicase
A6A40_RS07935	COG2197	response regulator
A6A40_RS07940	COG2197	response regulator
A6A40_RS07965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6A40_RS07975	COG2337	Toxic component of a toxin-antitoxin (TA) module
A6A40_RS07990	COG2910	NAD(P)H-binding
A6A40_RS08010	COG0742	ribosomal rna small subunit methyltransferase
A6A40_RS08015	COG1187	pseudouridine synthase activity
A6A40_RS08020	COG0590	tRNA wobble adenosine to inosine editing
A6A40_RS08035	COG1570	exodeoxyribonuclease VII activity
A6A40_RS08040	COG1053	succinate dehydrogenase
A6A40_RS08050	COG0418	dihydroorotase activity
A6A40_RS08070	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6A40_RS08075	COG0193	aminoacyl-tRNA hydrolase activity
A6A40_RS08080	COG0012	GTP binding
A6A40_RS08085	COG3300	MHYT domain
A6A40_RS08085	COG5001	Diguanylate cyclase
A6A40_RS08095	COG0583	DNA-binding transcription factor activity
A6A40_RS08130	COG2945	thiolester hydrolase activity
A6A40_RS08135	COG1045	serine acetyltransferase
A6A40_RS08150	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6A40_RS08160	COG0482	sulfurtransferase activity
A6A40_RS08180	COG3284	Transcriptional regulator
A6A40_RS08205	COG0488	(ABC) transporter
A6A40_RS08225	COG2001	Belongs to the MraZ family
A6A40_RS08245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6A40_RS08255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6A40_RS08260	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6A40_RS08270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6A40_RS08280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6A40_RS08285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6A40_RS08290	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6A40_RS08295	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6A40_RS08300	COG0849	cell division
A6A40_RS08305	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6A40_RS08320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6A40_RS08350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6A40_RS08355	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6A40_RS08370	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6A40_RS08385	COG2954	triphosphatase activity
A6A40_RS08400	COG1183	phosphatidylcholine synthase activity
A6A40_RS08425	COG4603	Belongs to the binding-protein-dependent transport system permease family
A6A40_RS08430	COG3845	ABC transporter
A6A40_RS08435	COG0354	folic acid binding
A6A40_RS08450	COG0546	phosphoglycolate phosphatase activity
A6A40_RS08455	COG0564	pseudouridine synthase activity
A6A40_RS08460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6A40_RS08465	COG1335	isochorismatase
A6A40_RS08475	COG1136	(ABC) transporter
A6A40_RS08485	COG0442	prolyl-tRNA aminoacylation
A6A40_RS08500	COG0519	Catalyzes the synthesis of GMP from XMP
A6A40_RS08510	COG0346	lactoylglutathione lyase activity
A6A40_RS08530	COG1007	ATP synthesis coupled electron transport
A6A40_RS08545	COG0713	ATP synthesis coupled electron transport
A6A40_RS08560	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6A40_RS08565	COG1034	ATP synthesis coupled electron transport
A6A40_RS08575	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A6A40_RS08580	COG0649	NAD binding
A6A40_RS08585	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6A40_RS08590	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6A40_RS08595	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6A40_RS08685	COG0500	methyltransferase
A6A40_RS08690	COG0140	phosphoribosyl-ATP diphosphatase activity
A6A40_RS08700	COG2862	Uncharacterized protein family, UPF0114
A6A40_RS08720	COG0768	penicillin binding
A6A40_RS08725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6A40_RS08735	COG0028	Belongs to the TPP enzyme family
A6A40_RS08740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6A40_RS08745	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6A40_RS08760	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6A40_RS08775	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A6A40_RS08780	COG0830	nickel cation binding
A6A40_RS08790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6A40_RS08795	COG0804	urea catabolic process
A6A40_RS08800	COG0832	Belongs to the urease beta subunit family
A6A40_RS08805	COG0831	urea catabolic process
A6A40_RS08810	COG0829	nickel cation binding
A6A40_RS08815	COG2197	response regulator
A6A40_RS08820	COG2197	response regulator
A6A40_RS08825	COG0693	protein deglycase activity
A6A40_RS08840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6A40_RS08845	COG0717	Belongs to the dCTP deaminase family
A6A40_RS08865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6A40_RS08900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6A40_RS08910	COG0557	exoribonuclease II activity
A6A40_RS08915	COG0793	Belongs to the peptidase S41A family
A6A40_RS08920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6A40_RS08925	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6A40_RS08940	COG1380	Effector of murein hydrolase LrgA
A6A40_RS08945	COG1346	cytolysis
A6A40_RS08950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6A40_RS08970	COG1496	oxidoreductase activity
A6A40_RS08975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6A40_RS09005	COG2197	response regulator
A6A40_RS09025	COG1131	(ABC) transporter
A6A40_RS09035	COG1309	transcriptional regulator
A6A40_RS09055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6A40_RS09070	COG5554	nitrogen fixation
A6A40_RS09095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6A40_RS09120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6A40_RS09130	COG0745	RESPONSE REGULATOR receiver
A6A40_RS09135	COG5002	protein histidine kinase activity
A6A40_RS09135	COG2176	DNA-directed DNA polymerase activity
A6A40_RS09145	COG5002	protein histidine kinase activity
A6A40_RS09150	COG2204	response regulator
A6A40_RS09160	COG0745	RESPONSE REGULATOR receiver
A6A40_RS09165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6A40_RS09210	COG0752	glycyl-tRNA synthetase alpha subunit
A6A40_RS09215	COG0751	glycine-tRNA ligase activity
A6A40_RS09220	COG0312	modulator of DNA gyrase
A6A40_RS09225	COG0004	ammonium transporteR
A6A40_RS09230	COG0047	phosphoribosylformylglycinamidine synthase activity
A6A40_RS09235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6A40_RS09255	COG0784	Response regulator, receiver
A6A40_RS09255	COG2198	Histidine kinase
A6A40_RS09255	COG2205	protein histidine kinase activity
A6A40_RS09280	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A6A40_RS09295	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6A40_RS09295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6A40_RS09310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6A40_RS09320	COG0463	Glycosyl transferase, family 2
A6A40_RS09345	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6A40_RS09360	COG3118	belongs to the thioredoxin family
A6A40_RS09370	COG2835	tetraacyldisaccharide 4'-kinase activity
A6A40_RS09380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6A40_RS09385	COG1028	Short-chain dehydrogenase reductase Sdr
A6A40_RS09390	COG0183	Belongs to the thiolase family
A6A40_RS09395	COG3243	poly(R)-hydroxyalkanoic acid synthase
A6A40_RS09405	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
A6A40_RS09440	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A6A40_RS09445	COG0842	Transport permease protein
A6A40_RS09450	COG1132	(ABC) transporter
A6A40_RS09455	COG2311	Membrane
A6A40_RS09465	COG0254	rRNA binding
A6A40_RS09475	COG0071	Belongs to the small heat shock protein (HSP20) family
A6A40_RS09490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6A40_RS09495	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6A40_RS09500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6A40_RS09510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6A40_RS09520	COG0793	Belongs to the peptidase S41A family
A6A40_RS09525	COG4942	peptidase
A6A40_RS09530	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A6A40_RS09535	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6A40_RS09540	COG0799	negative regulation of ribosome biogenesis
A6A40_RS09545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6A40_RS09560	COG1051	belongs to the nudix hydrolase family
A6A40_RS09570	COG0745	RESPONSE REGULATOR receiver
A6A40_RS09575	COG0643	Histidine kinase
A6A40_RS09575	COG2198	Histidine kinase
A6A40_RS09580	COG0835	chemotaxis
A6A40_RS09585	COG0840	transmembrane signaling receptor activity
A6A40_RS09600	COG2201	protein-glutamate methylesterase activity
A6A40_RS09610	COG1366	Belongs to the anti-sigma-factor antagonist family
A6A40_RS09630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6A40_RS09635	COG0579	oxidoreductase
A6A40_RS09640	COG0071	Belongs to the small heat shock protein (HSP20) family
A6A40_RS09660	COG0840	transmembrane signaling receptor activity
A6A40_RS09670	COG1322	Protein conserved in bacteria
A6A40_RS09685	COG1028	Short-chain dehydrogenase reductase Sdr
A6A40_RS09690	COG0436	Aminotransferase
A6A40_RS09735	COG1278	Cold shock
A6A40_RS09740	COG1902	pentaerythritol trinitrate reductase activity
A6A40_RS09755	COG3719	Belongs to the RNase T2 family
A6A40_RS09770	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A6A40_RS09780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6A40_RS09785	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A6A40_RS09800	COG2193	ferroxidase activity
A6A40_RS09810	COG1192	Involved in chromosome partitioning
A6A40_RS09815	COG0009	L-threonylcarbamoyladenylate synthase
A6A40_RS09820	COG0277	FAD linked oxidase domain protein
A6A40_RS09825	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6A40_RS09835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6A40_RS09840	COG0747	negative chemotaxis
A6A40_RS09855	COG0101	tRNA pseudouridine synthase activity
A6A40_RS09860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6A40_RS09865	COG0242	peptide deformylase activity
A6A40_RS09870	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A6A40_RS09885	COG0513	Belongs to the DEAD box helicase family
A6A40_RS09900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6A40_RS09905	COG2084	Dehydrogenase
A6A40_RS09925	COG1199	ATP-dependent helicase activity
A6A40_RS09925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6A40_RS09930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6A40_RS09940	COG1595	DNA-templated transcription, initiation
A6A40_RS09960	COG2205	protein histidine kinase activity
A6A40_RS09960	COG3850	Histidine kinase
A6A40_RS09960	COG3437	response regulator, receiver
A6A40_RS09960	COG4999	Histidine kinase
A6A40_RS09985	COG3279	Response regulator of the LytR AlgR family
A6A40_RS09995	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6A40_RS10010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6A40_RS10025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6A40_RS10040	COG2350	Protein conserved in bacteria
A6A40_RS10060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A6A40_RS10065	COG2205	protein histidine kinase activity
A6A40_RS10075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6A40_RS10085	COG2885	chlorophyll binding
A6A40_RS10095	COG0586	Pfam SNARE associated Golgi protein
A6A40_RS10115	COG1278	Cold shock
A6A40_RS10155	COG0559	Belongs to the binding-protein-dependent transport system permease family
A6A40_RS10165	COG3327	negative regulation of DNA-templated transcription, initiation
A6A40_RS10195	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A6A40_RS10210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6A40_RS10225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6A40_RS10230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6A40_RS10240	COG0167	dihydroorotate dehydrogenase activity
A6A40_RS10305	COG2032	superoxide dismutase activity
A6A40_RS10310	COG0513	Belongs to the DEAD box helicase family
A6A40_RS10315	COG0625	glutathione transferase activity
A6A40_RS10325	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6A40_RS10335	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6A40_RS10345	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6A40_RS10365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6A40_RS10375	COG4974	Belongs to the 'phage' integrase family
A6A40_RS10380	COG0840	transmembrane signaling receptor activity
A6A40_RS10380	COG0840	transmembrane signaling receptor activity
A6A40_RS10385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6A40_RS10400	COG1278	Cold shock
A6A40_RS10415	COG4191	Histidine kinase
A6A40_RS10425	COG4106	trans-aconitate 2-methyltransferase activity
A6A40_RS10440	COG0126	phosphoglycerate kinase activity
A6A40_RS10460	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6A40_RS10475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6A40_RS10485	COG0825	malonyl-CoA metabolic process
A6A40_RS10505	COG2358	TRAP transporter, solute receptor (TAXI family
A6A40_RS10530	COG2202	Pas domain
A6A40_RS10530	COG2205	protein histidine kinase activity
A6A40_RS10555	COG1595	DNA-templated transcription, initiation
A6A40_RS10560	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6A40_RS10575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6A40_RS10585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6A40_RS10600	COG1695	Transcriptional regulator
A6A40_RS10610	COG0492	ferredoxin-NADP+ reductase activity
A6A40_RS10615	COG0601	transmembrane transport
A6A40_RS10620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6A40_RS10625	COG0444	Belongs to the ABC transporter superfamily
A6A40_RS10630	COG4608	Belongs to the ABC transporter superfamily
A6A40_RS10655	COG0583	DNA-binding transcription factor activity
A6A40_RS10660	COG0604	alcohol dehydrogenase
A6A40_RS10675	COG4566	intracellular signal transduction
A6A40_RS10690	COG0459	protein refolding
A6A40_RS10695	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6A40_RS10700	COG5425	PFAM Usg family protein
A6A40_RS10710	COG3772	lysozyme
A6A40_RS10715	COG1612	heme a metabolic process
A6A40_RS10720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6A40_RS10755	COG3278	Belongs to the heme-copper respiratory oxidase family
A6A40_RS10765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6A40_RS10785	COG1177	transmembrane transport
A6A40_RS10805	COG0156	8-amino-7-oxononanoate synthase activity
A6A40_RS10810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6A40_RS10820	COG0135	phosphoribosylanthranilate isomerase activity
A6A40_RS10835	COG5265	(ABC) transporter
A6A40_RS10840	COG0840	transmembrane signaling receptor activity
A6A40_RS10880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6A40_RS10895	COG1253	flavin adenine dinucleotide binding
A6A40_RS10910	COG0583	DNA-binding transcription factor activity
A6A40_RS10935	COG0138	bifunctional purine biosynthesis protein purh
A6A40_RS10945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6A40_RS10945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6A40_RS10955	COG1024	Enoyl-CoA hydratase
A6A40_RS10965	COG0477	Major facilitator Superfamily
A6A40_RS10970	COG0583	DNA-binding transcription factor activity
A6A40_RS10985	COG1272	protein, Hemolysin III
A6A40_RS11020	COG0137	argininosuccinate synthase activity
A6A40_RS11050	COG3920	Histidine kinase
A6A40_RS11055	COG2423	ornithine cyclodeaminase activity
A6A40_RS11065	COG0776	regulation of translation
A6A40_RS11080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6A40_RS11100	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A6A40_RS11110	COG0783	Belongs to the Dps family
A6A40_RS11120	COG0840	transmembrane signaling receptor activity
A6A40_RS11125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6A40_RS11130	COG3585	molybdate ion transport
A6A40_RS11165	COG5001	Diguanylate cyclase
A6A40_RS11165	COG3300	MHYT domain
A6A40_RS11205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6A40_RS11215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6A40_RS11245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6A40_RS11260	COG3437	response regulator, receiver
A6A40_RS11260	COG0784	Response regulator, receiver
A6A40_RS11265	COG3813	Protein conserved in bacteria
A6A40_RS11270	COG0625	glutathione transferase activity
A6A40_RS11275	COG1473	amidohydrolase
A6A40_RS11285	COG5001	Diguanylate cyclase
A6A40_RS11305	COG4106	trans-aconitate 2-methyltransferase activity
A6A40_RS11315	COG1040	competence protein
A6A40_RS11325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6A40_RS11335	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A6A40_RS11345	COG3162	membrane
A6A40_RS11375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6A40_RS11380	COG0542	response to heat
A6A40_RS11400	COG2890	protein-(glutamine-N5) methyltransferase activity
A6A40_RS11405	COG2852	Protein conserved in bacteria
A6A40_RS11415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6A40_RS11420	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6A40_RS11435	COG2070	2-Nitropropane dioxygenase
A6A40_RS11445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6A40_RS11450	COG4636	protein conserved in cyanobacteria
A6A40_RS11455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A40_RS11460	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6A40_RS11465	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A6A40_RS11470	COG1137	ATPase activity
A6A40_RS11485	COG0517	IMP dehydrogenase activity
A6A40_RS11485	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6A40_RS11505	COG2223	nitrite transmembrane transporter activity
A6A40_RS11545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6A40_RS11550	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6A40_RS11555	COG2205	protein histidine kinase activity
A6A40_RS11560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6A40_RS11570	COG1573	uracil-dna glycosylase
A6A40_RS11580	COG2154	pterin-4-alpha-carbinolamine dehydratase
A6A40_RS11585	COG2972	Histidine kinase
A6A40_RS11585	COG0840	transmembrane signaling receptor activity
A6A40_RS11590	COG4166	transmembrane transport
A6A40_RS11595	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6A40_RS11610	COG0039	L-malate dehydrogenase activity
A6A40_RS11630	COG0598	Magnesium transport protein CorA
A6A40_RS11635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6A40_RS11640	COG1872	DUF167
A6A40_RS11655	COG1715	Restriction endonuclease
A6A40_RS11685	COG3335	DDE superfamily endonuclease
A6A40_RS11705	COG0285	dihydrofolate synthase activity
A6A40_RS11710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6A40_RS11720	COG0133	tryptophan synthase activity
A6A40_RS11725	COG2205	protein histidine kinase activity
A6A40_RS11725	COG5002	protein histidine kinase activity
A6A40_RS11725	COG0784	Response regulator, receiver
A6A40_RS11730	COG1278	Cold shock
A6A40_RS11735	COG2204	response regulator
A6A40_RS11740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6A40_RS11750	COG0784	Response regulator, receiver
A6A40_RS11750	COG2205	protein histidine kinase activity
A6A40_RS11750	COG5002	protein histidine kinase activity
A6A40_RS11755	COG2205	protein histidine kinase activity
A6A40_RS11765	COG4974	Belongs to the 'phage' integrase family
A6A40_RS11780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6A40_RS11805	COG0271	Belongs to the BolA IbaG family
A6A40_RS11830	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A6A40_RS11835	COG0501	Belongs to the peptidase M48B family
A6A40_RS11850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6A40_RS11860	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6A40_RS11860	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A40_RS11865	COG1660	Displays ATPase and GTPase activities
A6A40_RS11880	COG0642	Histidine kinase
A6A40_RS11885	COG0745	RESPONSE REGULATOR receiver
A6A40_RS11895	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A6A40_RS11940	COG4957	zinc ion binding
A6A40_RS11960	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A6A40_RS11980	COG0443	Heat shock 70 kDa protein
A6A40_RS11990	COG3706	GGDEF domain
A6A40_RS11995	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A6A40_RS12000	COG0667	Aldo Keto reductase
A6A40_RS12015	COG4181	ATPase activity
A6A40_RS12025	COG0670	Belongs to the BI1 family
A6A40_RS12035	COG0745	RESPONSE REGULATOR receiver
A6A40_RS12040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6A40_RS12050	COG0573	inorganic phosphate transmembrane transporter activity
A6A40_RS12055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6A40_RS12060	COG5002	protein histidine kinase activity
A6A40_RS12075	COG0281	malic enzyme
A6A40_RS12075	COG0280	phosphate acetyltransferase
A6A40_RS12080	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6A40_RS12085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6A40_RS12090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6A40_RS12095	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6A40_RS12110	COG0357	Ribosomal RNA small subunit methyltransferase G
A6A40_RS12115	COG0445	tRNA wobble uridine modification
A6A40_RS12135	COG1331	Highly conserved protein containing a thioredoxin domain
A6A40_RS12150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6A40_RS12185	COG1981	membrane
A6A40_RS12190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6A40_RS12210	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A6A40_RS12215	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6A40_RS12275	COG4235	cytochrome complex assembly
A6A40_RS12280	COG3088	subunit of a heme lyase
A6A40_RS12285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6A40_RS12290	COG1138	Cytochrome C-type biogenesis protein
A6A40_RS12295	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A6A40_RS12305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6A40_RS12325	COG1028	Short-chain dehydrogenase reductase Sdr
A6A40_RS12330	COG1185	polyribonucleotide nucleotidyltransferase activity
A6A40_RS12335	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6A40_RS12340	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6A40_RS12365	COG0779	Required for maturation of 30S ribosomal subunits
A6A40_RS12370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6A40_RS12375	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6A40_RS12380	COG1396	sequence-specific DNA binding
A6A40_RS12385	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6A40_RS12390	COG1253	flavin adenine dinucleotide binding
A6A40_RS12400	COG1702	phosphate starvation-inducible protein PhoH
A6A40_RS12405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6A40_RS12415	COG2967	ApaG domain
A6A40_RS12420	COG0302	gtp cyclohydrolase
A6A40_RS12425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6A40_RS12445	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6A40_RS12450	COG0668	transmembrane transport
A6A40_RS12465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6A40_RS12480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6A40_RS12495	COG0730	response to heat
A6A40_RS12510	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6A40_RS12520	COG0745	RESPONSE REGULATOR receiver
A6A40_RS12530	COG1420	regulation of RNA biosynthetic process
A6A40_RS12545	COG0606	chelatase, subunit chli
A6A40_RS12570	COG0180	Tryptophanyl-tRNA synthetase
A6A40_RS12585	COG0792	nuclease activity
A6A40_RS12590	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6A40_RS12620	COG2985	domain, Protein
A6A40_RS12620	COG0569	domain protein
A6A40_RS12630	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6A40_RS12635	COG0386	Belongs to the glutathione peroxidase family
A6A40_RS12645	COG0739	heme binding
A6A40_RS12675	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A6A40_RS12680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6A40_RS12685	COG0583	DNA-binding transcription factor activity
A6A40_RS12690	COG5383	Protein conserved in bacteria
A6A40_RS12695	COG5001	Diguanylate cyclase
A6A40_RS12695	COG3300	MHYT domain
A6A40_RS12745	COG1706	bacterial-type flagellum-dependent cell motility
A6A40_RS12760	COG1749	Flagellar hook protein flgE
A6A40_RS12765	COG1360	Flagellar Motor Protein
A6A40_RS12770	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6A40_RS12780	COG4786	Flagellar basal body rod
A6A40_RS12785	COG4786	Flagellar basal body rod
A6A40_RS12790	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
A6A40_RS12795	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6A40_RS12835	COG1766	The M ring may be actively involved in energy transduction
A6A40_RS12845	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6A40_RS12850	COG1338	Plays a role in the flagellum-specific transport system
A6A40_RS12860	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6A40_RS12875	COG0745	RESPONSE REGULATOR receiver
A6A40_RS12880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6A40_RS12890	COG5443	negative regulation of bacterial-type flagellum assembly
A6A40_RS12930	COG1558	bacterial-type flagellum-dependent cell motility
A6A40_RS12935	COG1677	Flagellar hook-basal body complex protein FliE
A6A40_RS12950	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6A40_RS12960	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6A40_RS12965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6A40_RS12970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6A40_RS12975	COG0351	phosphomethylpyrimidine kinase
A6A40_RS12980	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6A40_RS13025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6A40_RS13030	COG0569	domain protein
A6A40_RS13035	COG0625	glutathione transferase activity
A6A40_RS13045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6A40_RS13050	COG0573	inorganic phosphate transmembrane transporter activity
A6A40_RS13060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6A40_RS13085	COG1032	radical SAM domain protein
A6A40_RS13115	COG3920	Histidine kinase
A6A40_RS13135	COG5002	protein histidine kinase activity
A6A40_RS13135	COG2205	protein histidine kinase activity
A6A40_RS13135	COG0784	Response regulator, receiver
A6A40_RS13150	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6A40_RS13155	COG1802	Transcriptional regulator
A6A40_RS13160	COG0246	Mannitol dehydrogenase
A6A40_RS13165	COG1063	alcohol dehydrogenase
A6A40_RS13170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6A40_RS13180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6A40_RS13185	COG1312	Catalyzes the dehydration of D-mannonate
A6A40_RS13190	COG3290	protein histidine kinase activity
A6A40_RS13190	COG3829	transcription factor binding
A6A40_RS13195	COG5002	protein histidine kinase activity
A6A40_RS13200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A6A40_RS13205	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6A40_RS13205	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A6A40_RS13215	COG3604	Transcriptional regulator
A6A40_RS13230	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6A40_RS13235	COG1737	Transcriptional regulator
A6A40_RS13245	COG1538	Outer membrane efflux protein
A6A40_RS13260	COG2885	chlorophyll binding
A6A40_RS13260	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6A40_RS13315	COG1940	carbohydrate kinase activity
A6A40_RS13335	COG0463	Glycosyl transferase, family 2
A6A40_RS13355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6A40_RS13355	COG4191	Histidine kinase
A6A40_RS13360	COG1238	metal cluster binding
A6A40_RS13375	COG1858	cytochrome C peroxidase
A6A40_RS13405	COG0789	Transcriptional regulator
A6A40_RS13415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6A40_RS13440	COG3842	ATPase activity
A6A40_RS13445	COG3842	ATPase activity
A6A40_RS13460	COG1349	DNA-binding transcription factor activity
A6A40_RS13470	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A6A40_RS13475	COG1012	belongs to the aldehyde dehydrogenase family
A6A40_RS13525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6A40_RS13530	COG0697	spore germination
A6A40_RS13540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6A40_RS13575	COG2814	Major facilitator Superfamily
A6A40_RS13580	COG1744	ABC transporter substrate-binding protein PnrA-like
A6A40_RS13590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6A40_RS13610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6A40_RS13620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6A40_RS13630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6A40_RS13630	COG2205	protein histidine kinase activity
A6A40_RS13645	COG0372	Belongs to the citrate synthase family
A6A40_RS13655	COG2204	response regulator
A6A40_RS13665	COG1620	l-lactate permease
A6A40_RS13675	COG0247	lactate metabolic process
A6A40_RS13680	COG1139	Iron-sulfur cluster binding protein
A6A40_RS13695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6A40_RS13715	COG1573	uracil-dna glycosylase
A6A40_RS13720	COG0741	lytic transglycosylase activity
A6A40_RS13725	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6A40_RS13740	COG2703	oxygen carrier activity
A6A40_RS13755	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A6A40_RS13765	COG2205	protein histidine kinase activity
A6A40_RS13765	COG2202	Pas domain
A6A40_RS13785	COG3218	ABC-type transport auxiliary lipoprotein component
A6A40_RS13785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6A40_RS13790	COG1127	ABC transporter
A6A40_RS13795	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6A40_RS13800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6A40_RS13815	COG3971	2-oxopent-4-enoate hydratase activity
A6A40_RS13820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6A40_RS13840	COG0840	transmembrane signaling receptor activity
A6A40_RS13855	COG0598	Magnesium transport protein CorA
A6A40_RS13870	COG2010	Cytochrome c
A6A40_RS13885	COG0305	Participates in initiation and elongation during chromosome replication
A6A40_RS13890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6A40_RS13895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6A40_RS13900	COG1127	ABC transporter
A6A40_RS13925	COG2723	6-phospho-beta-galactosidase activity
A6A40_RS13940	COG2086	electron transfer activity
A6A40_RS13950	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6A40_RS13975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6A40_RS13995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6A40_RS14005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6A40_RS14020	COG4178	(ABC) transporter
A6A40_RS14050	COG1988	membrane-bound metal-dependent
A6A40_RS14060	COG0477	Major facilitator Superfamily
A6A40_RS14065	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6A40_RS14070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6A40_RS14075	COG1845	cytochrome c oxidase, subunit III
A6A40_RS14080	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A6A40_RS14095	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A6A40_RS14105	COG0791	NLP P60 protein
A6A40_RS14110	COG1648	precorrin-2 dehydrogenase activity
A6A40_RS14110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6A40_RS14115	COG0243	molybdopterin cofactor binding
A6A40_RS14125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6A40_RS14130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6A40_RS14140	COG1116	anion transmembrane transporter activity
A6A40_RS14145	COG0656	L-ascorbic acid biosynthetic process
A6A40_RS14155	COG1401	restriction endodeoxyribonuclease activity
A6A40_RS14190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6A40_RS14195	COG2017	converts alpha-aldose to the beta-anomer
A6A40_RS14200	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6A40_RS14205	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6A40_RS14210	COG1129	ABC transporter
A6A40_RS14215	COG1879	ABC-type sugar transport system periplasmic component
A6A40_RS14250	COG1129	ABC transporter
A6A40_RS14255	COG4214	carbohydrate transport
A6A40_RS14265	COG0129	dihydroxy-acid dehydratase activity
A6A40_RS14285	COG3706	GGDEF domain
A6A40_RS14290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6A40_RS14320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6A40_RS14325	COG3971	2-oxopent-4-enoate hydratase activity
A6A40_RS14345	COG1192	Involved in chromosome partitioning
A6A40_RS14355	COG0644	oxidoreductase
A6A40_RS14365	COG0318	PFAM AMP-dependent synthetase and ligase
A6A40_RS14375	COG3275	phosphorelay sensor kinase activity
A6A40_RS14380	COG3279	Response regulator of the LytR AlgR family
A6A40_RS14390	COG1295	ribonuclease BN
A6A40_RS14400	COG1966	Carbon starvation protein
A6A40_RS14425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6A40_RS14465	COG0859	PFAM glycosyl transferase family 9
A6A40_RS14480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6A40_RS14505	COG3118	belongs to the thioredoxin family
A6A40_RS14510	COG1074	ATP-dependent DNA helicase activity
A6A40_RS14515	COG2887	Belongs to the helicase family. UvrD subfamily
A6A40_RS14520	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6A40_RS14530	COG0802	atpase or kinase
A6A40_RS14545	COG0747	negative chemotaxis
A6A40_RS14555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6A40_RS14565	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A6A40_RS14585	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6A40_RS14595	COG1024	Enoyl-CoA hydratase