locus-tag	class	description
AZOLI_RS00050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AZOLI_RS00055	COG3706	GGDEF domain
AZOLI_RS00080	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AZOLI_RS00090	COG3842	ATPase activity
AZOLI_RS00095	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AZOLI_RS00100	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AZOLI_RS00120	COG2264	protein methyltransferase activity
AZOLI_RS00140	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AZOLI_RS00230	COG1234	tRNA 3'-trailer cleavage
AZOLI_RS00240	COG0745	RESPONSE REGULATOR receiver
AZOLI_RS00265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AZOLI_RS00325	COG3335	DDE superfamily endonuclease
AZOLI_RS00330	COG1509	lysine 2,3-aminomutase activity
AZOLI_RS00335	COG0584	glycerophosphoryl diester phosphodiesterase
AZOLI_RS00360	COG2205	protein histidine kinase activity
AZOLI_RS00360	COG2202	Pas domain
AZOLI_RS00375	COG3162	membrane
AZOLI_RS00390	COG0318	PFAM AMP-dependent synthetase and ligase
AZOLI_RS00405	COG1960	acyl-CoA dehydrogenase activity
AZOLI_RS00410	COG1187	pseudouridine synthase activity
AZOLI_RS00420	COG3335	DDE superfamily endonuclease
AZOLI_RS00430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AZOLI_RS00440	COG4974	Belongs to the 'phage' integrase family
AZOLI_RS00445	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AZOLI_RS00450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AZOLI_RS00455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AZOLI_RS00470	COG3437	response regulator, receiver
AZOLI_RS00470	COG0784	Response regulator, receiver
AZOLI_RS00480	COG0583	DNA-binding transcription factor activity
AZOLI_RS00490	COG0252	asparaginase activity
AZOLI_RS00515	COG0297	glycogen (starch) synthase activity
AZOLI_RS00520	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AZOLI_RS00525	COG0004	ammonium transporteR
AZOLI_RS00530	COG1741	Belongs to the pirin family
AZOLI_RS00550	COG2313	pseudouridylate synthase activity
AZOLI_RS00560	COG1793	dna ligase
AZOLI_RS00560	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AZOLI_RS00575	COG3660	Nucleoside-diphosphate-sugar epimerase
AZOLI_RS00580	COG1522	sequence-specific DNA binding
AZOLI_RS00585	COG2059	Chromate
AZOLI_RS00595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AZOLI_RS00600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AZOLI_RS00615	COG3005	denitrification pathway
AZOLI_RS00650	COG2205	protein histidine kinase activity
AZOLI_RS00660	COG2318	DinB family
AZOLI_RS00665	COG1674	ftsk spoiiie
AZOLI_RS00675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AZOLI_RS00685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AZOLI_RS00690	COG1238	metal cluster binding
AZOLI_RS00700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AZOLI_RS00700	COG2755	lipolytic protein G-D-S-L family
AZOLI_RS00760	COG0539	negative regulation of cytoplasmic translation
AZOLI_RS00770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AZOLI_RS00780	COG0574	Belongs to the PEP-utilizing enzyme family
AZOLI_RS00780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AZOLI_RS00785	COG1396	sequence-specific DNA binding
AZOLI_RS00795	COG1643	Atp-dependent helicase
AZOLI_RS00815	COG1366	Belongs to the anti-sigma-factor antagonist family
AZOLI_RS00840	COG4191	Histidine kinase
AZOLI_RS00845	COG0508	dehydrogenase complex catalyzes the overall conversion of
AZOLI_RS00860	COG0045	succinate-CoA ligase (ADP-forming) activity
AZOLI_RS00865	COG0039	L-malate dehydrogenase activity
AZOLI_RS00885	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AZOLI_RS00895	COG0640	Transcriptional regulator
AZOLI_RS00910	COG1970	mechanosensitive ion channel activity
AZOLI_RS00915	COG0653	protein targeting
AZOLI_RS00920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AZOLI_RS00925	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AZOLI_RS00930	COG0494	nUDIX hydrolase
AZOLI_RS00935	COG0514	ATP-dependent DNA helicase (RecQ)
AZOLI_RS00950	COG0024	Methionine aminopeptidase
AZOLI_RS00955	COG1489	DNA binding
AZOLI_RS00960	COG1546	Belongs to the CinA family
AZOLI_RS00960	COG1058	Belongs to the CinA family
AZOLI_RS00980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AZOLI_RS00985	COG0640	Transcriptional regulator
AZOLI_RS00995	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AZOLI_RS01000	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AZOLI_RS01005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AZOLI_RS01010	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AZOLI_RS01015	COG1842	Phage shock protein A
AZOLI_RS01040	COG1442	glycosyl transferase family 8
AZOLI_RS01040	COG1216	Glycosyl transferase, family 2
AZOLI_RS01070	COG0181	hydroxymethylbilane synthase activity
AZOLI_RS01080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AZOLI_RS01105	COG0587	DNA-directed DNA polymerase activity
AZOLI_RS01120	COG0784	Response regulator, receiver
AZOLI_RS01120	COG3437	response regulator, receiver
AZOLI_RS01125	COG3158	transport of potassium into the cell
AZOLI_RS01145	COG3609	addiction module antidote protein, CC2985 family
AZOLI_RS01155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AZOLI_RS01160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AZOLI_RS01165	COG0842	Transport permease protein
AZOLI_RS01170	COG2137	regulation of response to DNA damage stimulus
AZOLI_RS01175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AZOLI_RS01185	COG1703	isobutyryl-CoA mutase activity
AZOLI_RS01190	COG4172	Belongs to the ABC transporter superfamily
AZOLI_RS01195	COG4239	(ABC) transporter, permease
AZOLI_RS01200	COG4174	ABC transporter (Permease)
AZOLI_RS01205	COG4166	transmembrane transport
AZOLI_RS01210	COG4166	transmembrane transport
AZOLI_RS01245	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AZOLI_RS01250	COG3474	cytochrome
AZOLI_RS01265	COG2766	serine protein kinase
AZOLI_RS01270	COG2718	Belongs to the UPF0229 family
AZOLI_RS01275	COG2719	SpoVR family
AZOLI_RS01290	COG0318	PFAM AMP-dependent synthetase and ligase
AZOLI_RS01295	COG1254	Belongs to the acylphosphatase family
AZOLI_RS01325	COG2239	Acts as a magnesium transporter
AZOLI_RS01340	COG2022	thiamine diphosphate biosynthetic process
AZOLI_RS01350	COG2022	thiamine diphosphate biosynthetic process
AZOLI_RS01350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AZOLI_RS01355	COG0840	transmembrane signaling receptor activity
AZOLI_RS01430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AZOLI_RS01435	COG3108	Peptidase M15
AZOLI_RS01440	COG2003	Belongs to the UPF0758 family
AZOLI_RS01445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AZOLI_RS01450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AZOLI_RS01465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AZOLI_RS01470	COG0277	FAD linked oxidase domain protein
AZOLI_RS01475	COG0277	FAD linked oxidase domain protein
AZOLI_RS01480	COG0247	lactate metabolic process
AZOLI_RS01500	COG1454	alcohol dehydrogenase
AZOLI_RS01510	COG1960	acyl-CoA dehydrogenase activity
AZOLI_RS01530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AZOLI_RS01535	COG2171	N-acyltransferase activity
AZOLI_RS01570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AZOLI_RS01575	COG0228	four-way junction DNA binding
AZOLI_RS01580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AZOLI_RS01585	COG0336	Belongs to the RNA methyltransferase TrmD family
AZOLI_RS01590	COG0335	large ribosomal subunit rRNA binding
AZOLI_RS01595	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AZOLI_RS01605	COG0706	membrane insertase activity
AZOLI_RS01610	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AZOLI_RS01620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AZOLI_RS01630	COG0598	Magnesium transport protein CorA
AZOLI_RS01635	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AZOLI_RS01645	COG1530	ribonuclease E activity
AZOLI_RS01685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AZOLI_RS01685	COG0561	phosphatase activity
AZOLI_RS01695	COG1940	carbohydrate kinase activity
AZOLI_RS01720	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AZOLI_RS01725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AZOLI_RS01730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AZOLI_RS01845	COG3293	Transposase
AZOLI_RS01870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AZOLI_RS01890	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AZOLI_RS01895	COG0081	regulation of translation
AZOLI_RS01900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AZOLI_RS01905	COG0222	ribosome binding
AZOLI_RS01910	COG0085	RNA polymerase activity
AZOLI_RS01915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AZOLI_RS01925	COG0049	tRNA binding
AZOLI_RS01935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AZOLI_RS01940	COG0051	transcription antitermination factor activity, RNA binding
AZOLI_RS01950	COG0088	Forms part of the polypeptide exit tunnel
AZOLI_RS01955	COG0089	rRNA binding
AZOLI_RS01960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AZOLI_RS01965	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AZOLI_RS01970	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AZOLI_RS01975	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AZOLI_RS01980	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AZOLI_RS01985	COG0255	Belongs to the universal ribosomal protein uL29 family
AZOLI_RS01990	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AZOLI_RS02000	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AZOLI_RS02010	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AZOLI_RS02015	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AZOLI_RS02020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AZOLI_RS02030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AZOLI_RS02035	COG1841	ribosomal large subunit assembly
AZOLI_RS02040	COG0200	Binds to the 23S rRNA
AZOLI_RS02045	COG0201	protein transport
AZOLI_RS02050	COG0563	adenylate kinase activity
AZOLI_RS02060	COG0697	spore germination
AZOLI_RS02075	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AZOLI_RS02080	COG2873	o-acetylhomoserine
AZOLI_RS02085	COG1073	alpha beta
AZOLI_RS02085	COG2226	methyltransferase
AZOLI_RS02095	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AZOLI_RS02140	COG1285	pathogenesis
AZOLI_RS02145	COG2814	Major facilitator Superfamily
AZOLI_RS02150	COG0196	riboflavin kinase activity
AZOLI_RS02155	COG2030	dehydratase
AZOLI_RS02160	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AZOLI_RS02175	COG0628	permease
AZOLI_RS02205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AZOLI_RS02210	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AZOLI_RS02220	COG1597	lipid kinase activity
AZOLI_RS02230	COG0438	transferase activity, transferring glycosyl groups
AZOLI_RS02240	COG1280	lysine exporter protein (LysE YggA)
AZOLI_RS02255	COG1519	Transferase
AZOLI_RS02260	COG1663	tetraacyldisaccharide 4'-kinase activity
AZOLI_RS02290	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AZOLI_RS02295	COG0644	oxidoreductase
AZOLI_RS02350	COG1902	pentaerythritol trinitrate reductase activity
AZOLI_RS02360	COG2962	Rard protein
AZOLI_RS02375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AZOLI_RS02390	COG5002	protein histidine kinase activity
AZOLI_RS02405	COG0395	ABC-type sugar transport system, permease component
AZOLI_RS02415	COG5508	conserved small protein
AZOLI_RS02420	COG0501	Belongs to the peptidase M48B family
AZOLI_RS02490	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AZOLI_RS02505	COG3293	Transposase
AZOLI_RS02530	COG1686	Belongs to the peptidase S11 family
AZOLI_RS02545	COG2205	protein histidine kinase activity
AZOLI_RS02545	COG2202	Pas domain
AZOLI_RS02550	COG5002	protein histidine kinase activity
AZOLI_RS02555	COG2205	protein histidine kinase activity
AZOLI_RS02565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AZOLI_RS02580	COG0166	Belongs to the GPI family
AZOLI_RS02585	COG0612	Peptidase, M16
AZOLI_RS02590	COG0612	Peptidase, M16
AZOLI_RS02600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AZOLI_RS02605	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AZOLI_RS02635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AZOLI_RS02655	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AZOLI_RS02670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AZOLI_RS02675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AZOLI_RS02685	COG3609	addiction module antidote protein, CC2985 family
AZOLI_RS02700	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AZOLI_RS02705	COG0746	molybdenum cofactor guanylyltransferase activity
AZOLI_RS02730	COG0243	molybdopterin cofactor binding
AZOLI_RS02730	COG3383	formate dehydrogenase (NAD+) activity
AZOLI_RS02735	COG0437	4 iron, 4 sulfur cluster binding
AZOLI_RS02750	COG0235	Class ii aldolase
AZOLI_RS02755	COG2202	Pas domain
AZOLI_RS02755	COG2205	protein histidine kinase activity
AZOLI_RS02760	COG3384	dioxygenase
AZOLI_RS02765	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AZOLI_RS02770	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AZOLI_RS02775	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AZOLI_RS02780	COG0356	it plays a direct role in the translocation of protons across the membrane
AZOLI_RS02790	COG1999	signal sequence binding
AZOLI_RS02800	COG1702	phosphate starvation-inducible protein PhoH
AZOLI_RS02805	COG0850	regulation of cytokinetic process
AZOLI_RS02810	COG2894	cell division
AZOLI_RS02815	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AZOLI_RS02835	COG0840	transmembrane signaling receptor activity
AZOLI_RS02840	COG4948	Mandelate Racemase Muconate Lactonizing
AZOLI_RS02845	COG2154	pterin-4-alpha-carbinolamine dehydratase
AZOLI_RS02850	COG1573	uracil-dna glycosylase
AZOLI_RS02865	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AZOLI_RS02875	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AZOLI_RS02885	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
AZOLI_RS02890	COG5420	small protein containing a coiled-coil domain
AZOLI_RS02905	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AZOLI_RS02910	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AZOLI_RS02965	COG0121	glutamine amidotransferase
AZOLI_RS02975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AZOLI_RS02980	COG0552	protein localization to endoplasmic reticulum
AZOLI_RS02985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AZOLI_RS03000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AZOLI_RS03040	COG2301	Belongs to the HpcH HpaI aldolase family
AZOLI_RS03045	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AZOLI_RS03050	COG2205	protein histidine kinase activity
AZOLI_RS03055	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AZOLI_RS03080	COG3335	DDE superfamily endonuclease
AZOLI_RS03145	COG0582	viral genome integration into host DNA
AZOLI_RS03150	COG2972	Histidine kinase
AZOLI_RS03150	COG0840	transmembrane signaling receptor activity
AZOLI_RS03155	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AZOLI_RS03160	COG1063	alcohol dehydrogenase
AZOLI_RS03170	COG0508	dehydrogenase complex catalyzes the overall conversion of
AZOLI_RS03170	COG0596	Alpha beta hydrolase
AZOLI_RS03175	COG0022	dehydrogenase e1 component
AZOLI_RS03180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AZOLI_RS03185	COG3199	ATP-NAD kinase
AZOLI_RS03190	COG0277	FAD linked oxidase domain protein
AZOLI_RS03200	COG1671	Belongs to the UPF0178 family
AZOLI_RS03205	COG0488	(ABC) transporter
AZOLI_RS03235	COG2853	Lipoprotein
AZOLI_RS03245	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AZOLI_RS03255	COG1410	methionine synthase
AZOLI_RS03255	COG0646	methionine synthase
AZOLI_RS03290	COG2814	Major facilitator Superfamily
AZOLI_RS03300	COG2944	sequence-specific DNA binding
AZOLI_RS03310	COG0175	sulfate reduction
AZOLI_RS03315	COG0175	sulfate reduction
AZOLI_RS03320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AZOLI_RS03320	COG1648	precorrin-2 dehydrogenase activity
AZOLI_RS03330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AZOLI_RS03345	COG3108	Peptidase M15
AZOLI_RS03355	COG2202	Pas domain
AZOLI_RS03355	COG2205	protein histidine kinase activity
AZOLI_RS03360	COG4566	intracellular signal transduction
AZOLI_RS03385	COG0243	molybdopterin cofactor binding
AZOLI_RS03390	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AZOLI_RS03390	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AZOLI_RS03400	COG3657	addiction module killer protein
AZOLI_RS03405	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AZOLI_RS03410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AZOLI_RS03425	COG0612	Peptidase, M16
AZOLI_RS03430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AZOLI_RS03450	COG0483	inositol monophosphate 1-phosphatase activity
AZOLI_RS03455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AZOLI_RS03470	COG0730	response to heat
AZOLI_RS03475	COG0352	thiamine-phosphate diphosphorylase activity
AZOLI_RS03480	COG1830	Aldolase
AZOLI_RS03525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AZOLI_RS03530	COG1692	metallophosphoesterase
AZOLI_RS03535	COG0217	transcriptional regulatory protein
AZOLI_RS03545	COG0632	four-way junction helicase activity
AZOLI_RS03550	COG2255	four-way junction helicase activity
AZOLI_RS03555	COG0824	Thioesterase
AZOLI_RS03565	COG0848	biopolymer transport protein
AZOLI_RS03580	COG2885	chlorophyll binding
AZOLI_RS03590	COG0037	tRNA processing
AZOLI_RS03595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AZOLI_RS03605	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AZOLI_RS03615	COG3152	Membrane
AZOLI_RS03625	COG4520	surface antigen
AZOLI_RS03630	COG0259	pyridoxamine-phosphate oxidase activity
AZOLI_RS03645	COG1234	tRNA 3'-trailer cleavage
AZOLI_RS03650	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AZOLI_RS03655	COG2770	Histidine kinase
AZOLI_RS03655	COG3437	response regulator, receiver
AZOLI_RS03660	COG0409	Hydrogenase expression formation protein
AZOLI_RS03670	COG2153	protein acetylation
AZOLI_RS03685	COG3685	Protein conserved in bacteria
AZOLI_RS03700	COG4957	zinc ion binding
AZOLI_RS03705	COG0698	ribose 5-phosphate isomerase
AZOLI_RS03710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AZOLI_RS03715	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AZOLI_RS03720	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AZOLI_RS03730	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AZOLI_RS03735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AZOLI_RS03745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AZOLI_RS03745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AZOLI_RS03755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AZOLI_RS03755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AZOLI_RS03775	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AZOLI_RS03780	COG0416	fatty acid biosynthetic process
AZOLI_RS03785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AZOLI_RS03835	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AZOLI_RS03840	COG3436	PFAM IS66 Orf2 family protein
AZOLI_RS03845	COG4372	Transposase
AZOLI_RS03865	COG4608	Belongs to the ABC transporter superfamily
AZOLI_RS03870	COG0444	Belongs to the ABC transporter superfamily
AZOLI_RS03875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AZOLI_RS03885	COG0747	negative chemotaxis
AZOLI_RS03890	COG0583	DNA-binding transcription factor activity
AZOLI_RS03920	COG1028	Short-chain dehydrogenase reductase Sdr
AZOLI_RS03935	COG0583	DNA-binding transcription factor activity
AZOLI_RS03945	COG1028	Short-chain dehydrogenase reductase Sdr
AZOLI_RS03955	COG1764	response to oxidative stress
AZOLI_RS03960	COG1846	Transcriptional regulator
AZOLI_RS03965	COG0456	acetyltransferase
AZOLI_RS03975	COG2890	protein-(glutamine-N5) methyltransferase activity
AZOLI_RS03980	COG1393	Belongs to the ArsC family
AZOLI_RS03985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AZOLI_RS03995	COG1403	HNH endonuclease
AZOLI_RS04000	COG0697	spore germination
AZOLI_RS04025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AZOLI_RS04035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AZOLI_RS04060	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AZOLI_RS04095	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AZOLI_RS04120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AZOLI_RS04130	COG3108	Peptidase M15
AZOLI_RS04135	COG1396	sequence-specific DNA binding
AZOLI_RS04155	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AZOLI_RS04160	COG0511	ligase activity, forming carbon-carbon bonds
AZOLI_RS04165	COG0439	Biotin carboxylase
AZOLI_RS04170	COG0840	transmembrane signaling receptor activity
AZOLI_RS04180	COG4251	negative regulation of phosphorylation
AZOLI_RS04185	COG0784	Response regulator, receiver
AZOLI_RS04200	COG0745	RESPONSE REGULATOR receiver
AZOLI_RS04220	COG0432	Pfam Uncharacterised protein family UPF0047
AZOLI_RS04230	COG0745	RESPONSE REGULATOR receiver
AZOLI_RS04235	COG2205	protein histidine kinase activity
AZOLI_RS04240	COG0628	permease
AZOLI_RS04250	COG0105	UTP biosynthetic process
AZOLI_RS04280	COG0515	serine threonine protein kinase
AZOLI_RS04280	COG2815	serine threonine protein kinase
AZOLI_RS04305	COG0500	methyltransferase
AZOLI_RS04425	COG2770	Histidine kinase
AZOLI_RS04425	COG2208	phosphoserine phosphatase activity
AZOLI_RS04430	COG1366	Belongs to the anti-sigma-factor antagonist family
AZOLI_RS04455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AZOLI_RS04460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AZOLI_RS04465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AZOLI_RS04470	COG3237	CsbD-like
AZOLI_RS04485	COG1742	UPF0060 membrane protein
AZOLI_RS04495	COG5001	Diguanylate cyclase
AZOLI_RS04500	COG1840	ABC-type Fe3 transport system, periplasmic component
AZOLI_RS04505	COG3842	ATPase activity
AZOLI_RS04510	COG1132	(ABC) transporter
AZOLI_RS04515	COG1752	Esterase of the alpha-beta hydrolase superfamily
AZOLI_RS04535	COG1178	ABC-type Fe3 transport system permease component
AZOLI_RS04540	COG1217	gtp-binding protein TYPA
AZOLI_RS04580	COG1561	YicC-like family, N-terminal region
AZOLI_RS04585	COG4221	oxidoreductase activity
AZOLI_RS04595	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AZOLI_RS04600	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AZOLI_RS04605	COG0052	Belongs to the universal ribosomal protein uS2 family
AZOLI_RS04610	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AZOLI_RS04615	COG0528	UMP kinase activity
AZOLI_RS04620	COG0233	cytoplasmic translational termination
AZOLI_RS04625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AZOLI_RS04635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AZOLI_RS04640	COG0750	zinc metalloprotease
AZOLI_RS04665	COG3494	Protein of unknown function (DUF1009)
AZOLI_RS04670	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AZOLI_RS04680	COG4977	sequence-specific DNA binding
AZOLI_RS04695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AZOLI_RS04700	COG2333	competence protein COMEC
AZOLI_RS04700	COG0658	competence protein
AZOLI_RS04705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AZOLI_RS04710	COG0303	'Molybdopterin
AZOLI_RS04715	COG0315	cyclic pyranopterin monophosphate synthase activity
AZOLI_RS04760	COG0739	heme binding
AZOLI_RS04760	COG0741	lytic transglycosylase activity
AZOLI_RS04760	COG1196	nuclear chromosome segregation
AZOLI_RS04765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AZOLI_RS04770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AZOLI_RS04775	COG2813	Specifically methylates the guanine in position
AZOLI_RS04780	COG0667	Aldo Keto reductase
AZOLI_RS04795	COG1881	PFAM PEBP family protein
AZOLI_RS04800	COG0113	porphobilinogen synthase activity
AZOLI_RS04810	COG1597	lipid kinase activity
AZOLI_RS04815	COG1024	Enoyl-CoA hydratase
AZOLI_RS04820	COG1846	Transcriptional regulator
AZOLI_RS04835	COG0559	Belongs to the binding-protein-dependent transport system permease family
AZOLI_RS04850	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AZOLI_RS04860	COG2226	methyltransferase
AZOLI_RS04880	COG1028	Short-chain dehydrogenase reductase Sdr
AZOLI_RS04900	COG0058	SHG alpha-glucan phosphorylase activity
AZOLI_RS04905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AZOLI_RS04915	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AZOLI_RS04930	COG1305	Transglutaminase-like
AZOLI_RS04935	COG2307	Protein conserved in bacteria
AZOLI_RS04935	COG2308	Evidence 4 Homologs of previously reported genes of
AZOLI_RS04940	COG2010	Cytochrome c
AZOLI_RS04965	COG1028	Short-chain dehydrogenase reductase Sdr
AZOLI_RS04970	COG0583	DNA-binding transcription factor activity
AZOLI_RS05030	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AZOLI_RS05035	COG2814	Major facilitator Superfamily
AZOLI_RS05050	COG1160	GTP binding
AZOLI_RS05080	COG1121	(ABC) transporter
AZOLI_RS05100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AZOLI_RS05115	COG1595	DNA-templated transcription, initiation
AZOLI_RS05130	COG0024	Methionine aminopeptidase
AZOLI_RS05145	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AZOLI_RS05150	COG4221	oxidoreductase activity
AZOLI_RS05155	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AZOLI_RS05160	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AZOLI_RS05170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AZOLI_RS05175	COG0628	permease
AZOLI_RS05185	COG0300	oxidoreductase activity
AZOLI_RS05190	COG1846	Transcriptional regulator
AZOLI_RS05230	COG1396	sequence-specific DNA binding
AZOLI_RS05235	COG1216	Glycosyl transferase, family 2
AZOLI_RS05285	COG0745	RESPONSE REGULATOR receiver
AZOLI_RS05295	COG1846	Transcriptional regulator
AZOLI_RS05300	COG0149	triose-phosphate isomerase activity
AZOLI_RS05320	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AZOLI_RS05330	COG1566	PFAM secretion protein HlyD family protein
AZOLI_RS05335	COG1136	(ABC) transporter
AZOLI_RS05340	COG1136	(ABC) transporter
AZOLI_RS05340	COG0577	efflux transmembrane transporter activity
AZOLI_RS05370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AZOLI_RS05375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AZOLI_RS05380	COG0534	Mate efflux family protein
AZOLI_RS05415	COG1492	cobalamin metabolic process
AZOLI_RS05420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AZOLI_RS05440	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AZOLI_RS05445	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AZOLI_RS05470	COG0556	nucleotide-excision repair
AZOLI_RS05475	COG0741	lytic transglycosylase activity
AZOLI_RS05510	COG4957	zinc ion binding
AZOLI_RS05515	COG0776	regulation of translation
AZOLI_RS05530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AZOLI_RS05540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AZOLI_RS05545	COG0540	Belongs to the ATCase OTCase family
AZOLI_RS05550	COG0583	DNA-binding transcription factor activity
AZOLI_RS05575	COG0672	)-iron permease
AZOLI_RS05590	COG4120	Belongs to the binding-protein-dependent transport system permease family
AZOLI_RS05625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AZOLI_RS05630	COG1763	Mo-molybdopterin cofactor biosynthetic process
AZOLI_RS05635	COG0546	phosphoglycolate phosphatase activity
AZOLI_RS05645	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AZOLI_RS05650	COG0314	molybdopterin synthase activity
AZOLI_RS05655	COG1678	Uncharacterized ACR, COG1678
AZOLI_RS05665	COG2824	Alkylphosphonate utilization operon protein PhnA
AZOLI_RS05670	COG0678	peroxiredoxin activity
AZOLI_RS05680	COG0328	RNA-DNA hybrid ribonuclease activity
AZOLI_RS05685	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AZOLI_RS05690	COG2833	Protein of unknown function (DUF455)
AZOLI_RS05695	COG1218	3'(2'),5'-bisphosphate nucleotidase
AZOLI_RS05705	COG2200	EAL domain
AZOLI_RS05715	COG2135	peptidase activity
AZOLI_RS05730	COG2261	transglycosylase associated protein
AZOLI_RS05735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AZOLI_RS05740	COG0725	ABC transporter, periplasmic molybdate-binding protein
AZOLI_RS05745	COG4149	molybdate abc transporter
AZOLI_RS05765	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AZOLI_RS05770	COG0022	dehydrogenase e1 component
AZOLI_RS05770	COG0508	dehydrogenase complex catalyzes the overall conversion of
AZOLI_RS05775	COG0508	dehydrogenase complex catalyzes the overall conversion of
AZOLI_RS05785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AZOLI_RS05795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AZOLI_RS05800	COG2867	negative regulation of translational initiation
AZOLI_RS05805	COG1942	4-Oxalocrotonate Tautomerase
AZOLI_RS05815	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AZOLI_RS05815	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AZOLI_RS05845	COG2204	response regulator
AZOLI_RS05865	COG1923	regulation of RNA biosynthetic process
AZOLI_RS05870	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AZOLI_RS05885	COG0483	inositol monophosphate 1-phosphatase activity
AZOLI_RS05895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AZOLI_RS05900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AZOLI_RS05905	COG1116	anion transmembrane transporter activity
AZOLI_RS05910	COG0123	including yeast histone deacetylase and acetoin utilization protein
AZOLI_RS05940	COG0629	single-stranded DNA binding
AZOLI_RS05945	COG0583	DNA-binding transcription factor activity
AZOLI_RS05950	COG2814	Major facilitator Superfamily
AZOLI_RS05975	COG0714	Associated with various cellular activities
AZOLI_RS06000	COG0248	Ppx GppA phosphatase
AZOLI_RS06005	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AZOLI_RS06020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AZOLI_RS06040	COG1562	ergosterol biosynthetic process
AZOLI_RS06045	COG1562	ergosterol biosynthetic process
AZOLI_RS06050	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AZOLI_RS06055	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AZOLI_RS06070	COG3737	Protein of unknown function (DUF498/DUF598)
AZOLI_RS06080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AZOLI_RS06085	COG1862	Preprotein translocase
AZOLI_RS06100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AZOLI_RS06110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AZOLI_RS06120	COG2197	response regulator
AZOLI_RS06130	COG3290	protein histidine kinase activity
AZOLI_RS06130	COG0840	transmembrane signaling receptor activity
AZOLI_RS06135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AZOLI_RS06190	COG0604	alcohol dehydrogenase
AZOLI_RS06190	COG1028	Short-chain dehydrogenase reductase Sdr
AZOLI_RS06190	COG3321	synthase
AZOLI_RS06205	COG0288	reversible hydration of carbon dioxide
AZOLI_RS06230	COG0205	6-phosphofructokinase activity
AZOLI_RS06245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AZOLI_RS06250	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AZOLI_RS06255	COG5002	protein histidine kinase activity
AZOLI_RS06255	COG5001	Diguanylate cyclase
AZOLI_RS06280	COG0114	fumarate hydratase activity
AZOLI_RS06305	COG2951	lytic endotransglycosylase activity
AZOLI_RS06330	COG4191	Histidine kinase
AZOLI_RS06345	COG3346	SURF1 family
AZOLI_RS06355	COG1845	cytochrome c oxidase, subunit III
AZOLI_RS06360	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AZOLI_RS06370	COG0109	protoheme IX farnesyltransferase activity
AZOLI_RS06375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AZOLI_RS06380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AZOLI_RS06380	COG1565	acr, cog1565
AZOLI_RS06390	COG0312	modulator of DNA gyrase
AZOLI_RS06405	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AZOLI_RS06410	COG2076	Multidrug Resistance protein
AZOLI_RS06420	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AZOLI_RS06440	COG1309	transcriptional regulator
AZOLI_RS06480	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AZOLI_RS06495	COG1677	Flagellar hook-basal body complex protein FliE
AZOLI_RS06500	COG1558	bacterial-type flagellum-dependent cell motility
AZOLI_RS06505	COG1815	bacterial-type flagellum-dependent cell motility
AZOLI_RS06510	COG2257	FlhB HrpN YscU SpaS Family
AZOLI_RS06525	COG1338	Plays a role in the flagellum-specific transport system
AZOLI_RS06535	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AZOLI_RS06545	COG1360	Flagellar Motor Protein
AZOLI_RS06560	COG1752	Esterase of the alpha-beta hydrolase superfamily
AZOLI_RS06570	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AZOLI_RS06585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AZOLI_RS06590	COG0571	ribonuclease III activity
AZOLI_RS06595	COG0681	Belongs to the peptidase S26 family
AZOLI_RS06600	COG0736	holo-[acyl-carrier-protein] synthase activity
AZOLI_RS06605	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AZOLI_RS06615	COG1758	RNA polymerase activity
AZOLI_RS06630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AZOLI_RS06640	COG1247	-acetyltransferase
AZOLI_RS06645	COG0519	Catalyzes the synthesis of GMP from XMP
AZOLI_RS06690	COG1914	H( )-stimulated, divalent metal cation uptake system
AZOLI_RS06695	COG2900	Belongs to the SlyX family
AZOLI_RS06700	COG2132	Multicopper oxidase
AZOLI_RS06710	COG3335	DDE superfamily endonuclease
AZOLI_RS06725	COG4953	penicillin-binding protein 1C
AZOLI_RS06745	COG0583	DNA-binding transcription factor activity
AZOLI_RS06750	COG0303	'Molybdopterin
AZOLI_RS06755	COG1324	tolerance protein
AZOLI_RS06765	COG2205	protein histidine kinase activity
AZOLI_RS06770	COG1494	fructose-1,6-bisphosphatase
AZOLI_RS06780	COG0436	Aminotransferase
AZOLI_RS06785	COG0840	transmembrane signaling receptor activity
AZOLI_RS06800	COG0745	RESPONSE REGULATOR receiver
AZOLI_RS06810	COG0616	signal peptide processing
AZOLI_RS06815	COG0488	(ABC) transporter
AZOLI_RS06820	COG3932	Exopolysaccharide synthesis, ExoD
AZOLI_RS06835	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AZOLI_RS06840	COG0525	valine-tRNA ligase activity
AZOLI_RS06850	COG1538	Outer membrane efflux protein
AZOLI_RS06860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AZOLI_RS06890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AZOLI_RS06895	COG0494	nUDIX hydrolase
AZOLI_RS06905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AZOLI_RS06910	COG2897	thiosulfate sulfurtransferase activity
AZOLI_RS06915	COG1214	PFAM Peptidase M22, glycoprotease
AZOLI_RS06915	COG0456	acetyltransferase
AZOLI_RS06930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AZOLI_RS06935	COG1126	abc transporter atp-binding protein
AZOLI_RS06940	COG0765	amino acid transport
AZOLI_RS06945	COG4597	amino acid ABC transporter
AZOLI_RS06950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZOLI_RS06955	COG0626	cystathionine gamma-synthase activity
AZOLI_RS06975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AZOLI_RS06975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AZOLI_RS06995	COG2308	Evidence 4 Homologs of previously reported genes of
AZOLI_RS07000	COG1360	Flagellar Motor Protein
AZOLI_RS07005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AZOLI_RS07025	COG0318	PFAM AMP-dependent synthetase and ligase
AZOLI_RS07030	COG0789	Transcriptional regulator
AZOLI_RS07040	COG2086	electron transfer activity
AZOLI_RS07060	COG2205	protein histidine kinase activity
AZOLI_RS07065	COG0728	peptidoglycan biosynthetic process
AZOLI_RS07085	COG1765	OsmC-like protein
AZOLI_RS07090	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AZOLI_RS07110	COG1196	nuclear chromosome segregation
AZOLI_RS07110	COG0739	heme binding
AZOLI_RS07110	COG0741	lytic transglycosylase activity
AZOLI_RS07125	COG2226	methyltransferase
AZOLI_RS07135	COG0513	Belongs to the DEAD box helicase family
AZOLI_RS07155	COG0187	DNA topoisomerase II activity
AZOLI_RS07160	COG1607	acyl-coa hydrolase
AZOLI_RS07170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AZOLI_RS07175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AZOLI_RS07205	COG4191	Histidine kinase
AZOLI_RS07205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZOLI_RS07220	COG3437	response regulator, receiver
AZOLI_RS07220	COG0784	Response regulator, receiver
AZOLI_RS07230	COG3293	Transposase
AZOLI_RS07240	COG0140	phosphoribosyl-ATP diphosphatase activity
AZOLI_RS07270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AZOLI_RS07275	COG2198	Histidine kinase
AZOLI_RS07275	COG0643	Histidine kinase
AZOLI_RS07280	COG2201	protein-glutamate methylesterase activity
AZOLI_RS07285	COG2201	protein-glutamate methylesterase activity
AZOLI_RS07290	COG0835	chemotaxis
AZOLI_RS07300	COG0840	transmembrane signaling receptor activity
AZOLI_RS07305	COG0840	transmembrane signaling receptor activity
AZOLI_RS07320	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AZOLI_RS07325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AZOLI_RS07340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AZOLI_RS07350	COG0360	Binds together with S18 to 16S ribosomal RNA
AZOLI_RS07355	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AZOLI_RS07365	COG0359	binds to the 23S rRNA
AZOLI_RS07370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AZOLI_RS07375	COG0538	isocitrate dehydrogenase activity
AZOLI_RS07385	COG0330	HflC and HflK could
AZOLI_RS07415	COG0473	3-isopropylmalate dehydrogenase activity
AZOLI_RS07445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AZOLI_RS07500	COG1686	Belongs to the peptidase S11 family
AZOLI_RS07505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AZOLI_RS07510	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AZOLI_RS07515	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AZOLI_RS07520	COG0084	hydrolase, TatD family'
AZOLI_RS07525	COG0321	lipoyl(octanoyl) transferase activity
AZOLI_RS07525	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AZOLI_RS07530	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AZOLI_RS07545	COG1381	Involved in DNA repair and RecF pathway recombination
AZOLI_RS07550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AZOLI_RS07575	COG4786	Flagellar basal body rod
AZOLI_RS07580	COG4786	Flagellar basal body rod
AZOLI_RS07590	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AZOLI_RS07655	COG3772	lysozyme
AZOLI_RS07780	COG0305	Participates in initiation and elongation during chromosome replication
AZOLI_RS07885	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AZOLI_RS07895	COG1024	Enoyl-CoA hydratase
AZOLI_RS07905	COG0758	DNA mediated transformation
AZOLI_RS07910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AZOLI_RS07915	COG1024	Enoyl-CoA hydratase
AZOLI_RS07920	COG1832	CoA-binding protein
AZOLI_RS07925	COG2873	o-acetylhomoserine
AZOLI_RS07945	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AZOLI_RS07980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AZOLI_RS07995	COG0784	Response regulator, receiver
AZOLI_RS08000	COG5002	protein histidine kinase activity
AZOLI_RS08000	COG5001	Diguanylate cyclase
AZOLI_RS08000	COG3447	MASE1 domain protein
AZOLI_RS08020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AZOLI_RS08035	COG1238	metal cluster binding
AZOLI_RS08040	COG0203	ribosomal protein L17
AZOLI_RS08055	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AZOLI_RS08070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AZOLI_RS08075	COG0251	oxidation-reduction process
AZOLI_RS08135	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AZOLI_RS08135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AZOLI_RS08170	COG0154	amidase activity
AZOLI_RS08175	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AZOLI_RS08190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AZOLI_RS08200	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AZOLI_RS08220	COG0242	peptide deformylase activity
AZOLI_RS08225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AZOLI_RS08230	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AZOLI_RS08240	COG1201	RNA secondary structure unwinding
AZOLI_RS08255	COG0415	Belongs to the DNA photolyase family
AZOLI_RS08260	COG0735	belongs to the Fur family
AZOLI_RS08265	COG0523	cobalamin synthesis protein
AZOLI_RS08275	COG0840	transmembrane signaling receptor activity
AZOLI_RS08280	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AZOLI_RS08295	COG2205	protein histidine kinase activity
AZOLI_RS08305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AZOLI_RS08310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AZOLI_RS08310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AZOLI_RS08330	COG0497	DNA recombination
AZOLI_RS08335	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AZOLI_RS08355	COG0006	proline dipeptidase activity
AZOLI_RS08365	COG2264	protein methyltransferase activity
AZOLI_RS08375	COG0210	DNA helicase
AZOLI_RS08380	COG2197	response regulator
AZOLI_RS08385	COG2197	response regulator
AZOLI_RS08415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AZOLI_RS08435	COG2910	NAD(P)H-binding
AZOLI_RS08460	COG0742	ribosomal rna small subunit methyltransferase
AZOLI_RS08465	COG1187	pseudouridine synthase activity
AZOLI_RS08470	COG0590	tRNA wobble adenosine to inosine editing
AZOLI_RS08490	COG1570	exodeoxyribonuclease VII activity
AZOLI_RS08495	COG1053	succinate dehydrogenase
AZOLI_RS08505	COG0418	dihydroorotase activity
AZOLI_RS08515	COG0124	histidyl-tRNA synthetase
AZOLI_RS08525	COG0300	oxidoreductase activity
AZOLI_RS08530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AZOLI_RS08535	COG0193	aminoacyl-tRNA hydrolase activity
AZOLI_RS08540	COG0012	GTP binding
AZOLI_RS08545	COG1283	sodium-dependent phosphate transmembrane transporter activity
AZOLI_RS08550	COG3300	MHYT domain
AZOLI_RS08550	COG5001	Diguanylate cyclase
AZOLI_RS08560	COG0583	DNA-binding transcription factor activity
AZOLI_RS08595	COG2945	thiolester hydrolase activity
AZOLI_RS08600	COG1045	serine acetyltransferase
AZOLI_RS08615	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AZOLI_RS08625	COG0482	sulfurtransferase activity
AZOLI_RS08640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AZOLI_RS08670	COG5489	Protein of unknown function (DUF736)
AZOLI_RS08680	COG1396	sequence-specific DNA binding
AZOLI_RS08725	COG1074	ATP-dependent DNA helicase activity
AZOLI_RS08755	COG1518	maintenance of DNA repeat elements
AZOLI_RS08755	COG1468	defense response to virus
AZOLI_RS08760	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AZOLI_RS08780	COG2894	cell division
AZOLI_RS08855	COG4191	Histidine kinase
AZOLI_RS08890	COG2192	nodulation
AZOLI_RS08925	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AZOLI_RS08930	COG0732	type I restriction modification DNA specificity domain
AZOLI_RS08935	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AZOLI_RS08985	COG0582	viral genome integration into host DNA
AZOLI_RS09010	COG3335	DDE superfamily endonuclease
AZOLI_RS09070	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AZOLI_RS09090	COG0464	growth
AZOLI_RS09105	COG1028	Short-chain dehydrogenase reductase Sdr
AZOLI_RS09110	COG0534	Mate efflux family protein
AZOLI_RS09115	COG1309	transcriptional regulator
AZOLI_RS09145	COG3284	Transcriptional regulator
AZOLI_RS09170	COG0488	(ABC) transporter
AZOLI_RS09185	COG4636	protein conserved in cyanobacteria
AZOLI_RS09190	COG2001	Belongs to the MraZ family
AZOLI_RS09210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AZOLI_RS09220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AZOLI_RS09225	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AZOLI_RS09235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AZOLI_RS09245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AZOLI_RS09250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AZOLI_RS09255	COG1181	Belongs to the D-alanine--D-alanine ligase family
AZOLI_RS09260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AZOLI_RS09265	COG0849	cell division
AZOLI_RS09270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AZOLI_RS09285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AZOLI_RS09310	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AZOLI_RS09315	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AZOLI_RS09330	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AZOLI_RS09350	COG2954	triphosphatase activity
AZOLI_RS09370	COG1183	phosphatidylcholine synthase activity
AZOLI_RS09400	COG4603	Belongs to the binding-protein-dependent transport system permease family
AZOLI_RS09405	COG3845	ABC transporter
AZOLI_RS09410	COG0354	folic acid binding
AZOLI_RS09425	COG0546	phosphoglycolate phosphatase activity
AZOLI_RS09430	COG0564	pseudouridine synthase activity
AZOLI_RS09435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AZOLI_RS09440	COG1335	isochorismatase
AZOLI_RS09450	COG1136	(ABC) transporter
AZOLI_RS09460	COG0442	prolyl-tRNA aminoacylation
AZOLI_RS09475	COG0519	Catalyzes the synthesis of GMP from XMP
AZOLI_RS09485	COG0346	lactoylglutathione lyase activity
AZOLI_RS09505	COG1007	ATP synthesis coupled electron transport
AZOLI_RS09520	COG0713	ATP synthesis coupled electron transport
AZOLI_RS09535	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AZOLI_RS09540	COG1034	ATP synthesis coupled electron transport
AZOLI_RS09550	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AZOLI_RS09555	COG0649	NAD binding
AZOLI_RS09560	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AZOLI_RS09565	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AZOLI_RS09570	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AZOLI_RS09650	COG0500	methyltransferase
AZOLI_RS09655	COG0140	phosphoribosyl-ATP diphosphatase activity
AZOLI_RS09665	COG2862	Uncharacterized protein family, UPF0114
AZOLI_RS09685	COG0768	penicillin binding
AZOLI_RS09690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AZOLI_RS09710	COG0028	Belongs to the TPP enzyme family
AZOLI_RS09715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AZOLI_RS09720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AZOLI_RS09735	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AZOLI_RS09750	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AZOLI_RS09755	COG0830	nickel cation binding
AZOLI_RS09760	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AZOLI_RS09765	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AZOLI_RS09770	COG0804	urea catabolic process
AZOLI_RS09775	COG0832	Belongs to the urease beta subunit family
AZOLI_RS09780	COG0831	urea catabolic process
AZOLI_RS09785	COG0829	nickel cation binding
AZOLI_RS09790	COG2197	response regulator
AZOLI_RS09795	COG2197	response regulator
AZOLI_RS09800	COG0693	protein deglycase activity
AZOLI_RS09815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AZOLI_RS09820	COG0717	Belongs to the dCTP deaminase family
AZOLI_RS09840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AZOLI_RS09875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AZOLI_RS09885	COG0557	exoribonuclease II activity
AZOLI_RS09890	COG0793	Belongs to the peptidase S41A family
AZOLI_RS09895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AZOLI_RS09900	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AZOLI_RS09915	COG1380	Effector of murein hydrolase LrgA
AZOLI_RS09920	COG1346	cytolysis
AZOLI_RS09925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AZOLI_RS09950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AZOLI_RS09975	COG3381	protein complex oligomerization
AZOLI_RS09980	COG4191	Histidine kinase
AZOLI_RS09980	COG0784	Response regulator, receiver
AZOLI_RS09995	COG1131	(ABC) transporter
AZOLI_RS10005	COG1309	transcriptional regulator
AZOLI_RS10025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AZOLI_RS10040	COG5554	nitrogen fixation
AZOLI_RS10050	COG1104	cysteine desulfurase activity
AZOLI_RS10065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AZOLI_RS10085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AZOLI_RS10095	COG0745	RESPONSE REGULATOR receiver
AZOLI_RS10100	COG5002	protein histidine kinase activity
AZOLI_RS10100	COG2176	DNA-directed DNA polymerase activity
AZOLI_RS10110	COG5002	protein histidine kinase activity
AZOLI_RS10115	COG2204	response regulator
AZOLI_RS10120	COG3852	Histidine kinase
AZOLI_RS10130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AZOLI_RS10175	COG0752	glycyl-tRNA synthetase alpha subunit
AZOLI_RS10180	COG0751	glycine-tRNA ligase activity
AZOLI_RS10185	COG0312	modulator of DNA gyrase
AZOLI_RS10190	COG0004	ammonium transporteR
AZOLI_RS10195	COG0047	phosphoribosylformylglycinamidine synthase activity
AZOLI_RS10200	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AZOLI_RS10250	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AZOLI_RS10265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AZOLI_RS10265	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AZOLI_RS10280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AZOLI_RS10290	COG0463	Glycosyl transferase, family 2
AZOLI_RS10295	COG0840	transmembrane signaling receptor activity
AZOLI_RS10315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AZOLI_RS10330	COG3118	belongs to the thioredoxin family
AZOLI_RS10340	COG2835	tetraacyldisaccharide 4'-kinase activity
AZOLI_RS10350	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AZOLI_RS10360	COG1028	Short-chain dehydrogenase reductase Sdr
AZOLI_RS10365	COG0183	Belongs to the thiolase family
AZOLI_RS10370	COG3243	poly(R)-hydroxyalkanoic acid synthase
AZOLI_RS10375	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AZOLI_RS10410	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
AZOLI_RS10415	COG0842	Transport permease protein
AZOLI_RS10420	COG1132	(ABC) transporter
AZOLI_RS10425	COG2311	Membrane
AZOLI_RS10430	COG1309	transcriptional regulator
AZOLI_RS10435	COG0254	rRNA binding
AZOLI_RS10445	COG0071	Belongs to the small heat shock protein (HSP20) family
AZOLI_RS10465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AZOLI_RS10470	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AZOLI_RS10475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AZOLI_RS10485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AZOLI_RS10495	COG0793	Belongs to the peptidase S41A family
AZOLI_RS10500	COG4942	peptidase
AZOLI_RS10505	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AZOLI_RS10510	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AZOLI_RS10515	COG0799	negative regulation of ribosome biogenesis
AZOLI_RS10535	COG1051	belongs to the nudix hydrolase family
AZOLI_RS10545	COG0745	RESPONSE REGULATOR receiver
AZOLI_RS10550	COG0643	Histidine kinase
AZOLI_RS10550	COG2198	Histidine kinase
AZOLI_RS10555	COG0835	chemotaxis
AZOLI_RS10560	COG0840	transmembrane signaling receptor activity
AZOLI_RS10570	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AZOLI_RS10575	COG2201	protein-glutamate methylesterase activity
AZOLI_RS10580	COG0840	transmembrane signaling receptor activity
AZOLI_RS10585	COG1366	Belongs to the anti-sigma-factor antagonist family
AZOLI_RS10605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AZOLI_RS10610	COG0579	oxidoreductase
AZOLI_RS10615	COG0071	Belongs to the small heat shock protein (HSP20) family
AZOLI_RS10645	COG1322	Protein conserved in bacteria
AZOLI_RS10660	COG1028	Short-chain dehydrogenase reductase Sdr
AZOLI_RS10665	COG0436	Aminotransferase
AZOLI_RS10710	COG1278	Cold shock
AZOLI_RS10715	COG1902	pentaerythritol trinitrate reductase activity
AZOLI_RS10725	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AZOLI_RS10740	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AZOLI_RS10750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AZOLI_RS10755	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AZOLI_RS10770	COG2193	ferroxidase activity
AZOLI_RS10780	COG1192	Involved in chromosome partitioning
AZOLI_RS10785	COG0009	L-threonylcarbamoyladenylate synthase
AZOLI_RS10795	COG0277	FAD linked oxidase domain protein
AZOLI_RS10815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AZOLI_RS10820	COG0747	negative chemotaxis
AZOLI_RS10840	COG0101	tRNA pseudouridine synthase activity
AZOLI_RS10845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AZOLI_RS10850	COG0242	peptide deformylase activity
AZOLI_RS10855	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AZOLI_RS10870	COG0513	Belongs to the DEAD box helicase family
AZOLI_RS10890	COG3335	DDE superfamily endonuclease
AZOLI_RS10895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AZOLI_RS10905	COG2084	Dehydrogenase
AZOLI_RS10925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AZOLI_RS10925	COG1199	ATP-dependent helicase activity
AZOLI_RS10930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AZOLI_RS10940	COG1595	DNA-templated transcription, initiation
AZOLI_RS10960	COG2205	protein histidine kinase activity
AZOLI_RS10960	COG0784	Response regulator, receiver
AZOLI_RS10960	COG5002	protein histidine kinase activity
AZOLI_RS10975	COG3279	Response regulator of the LytR AlgR family
AZOLI_RS11000	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AZOLI_RS11015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AZOLI_RS11030	COG2350	Protein conserved in bacteria
AZOLI_RS11050	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AZOLI_RS11065	COG2205	protein histidine kinase activity
AZOLI_RS11075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AZOLI_RS11090	COG2885	chlorophyll binding
AZOLI_RS11100	COG0586	Pfam SNARE associated Golgi protein
AZOLI_RS11110	COG0517	IMP dehydrogenase activity
AZOLI_RS11110	COG0516	GMP reductase activity
AZOLI_RS11120	COG1278	Cold shock
AZOLI_RS11145	COG0625	glutathione transferase activity
AZOLI_RS11175	COG3327	negative regulation of DNA-templated transcription, initiation
AZOLI_RS11195	COG0840	transmembrane signaling receptor activity
AZOLI_RS11195	COG0840	transmembrane signaling receptor activity
AZOLI_RS11205	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AZOLI_RS11225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AZOLI_RS11240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AZOLI_RS11245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AZOLI_RS11255	COG0167	dihydroorotate dehydrogenase activity
AZOLI_RS11325	COG2032	superoxide dismutase activity
AZOLI_RS11330	COG0513	Belongs to the DEAD box helicase family
AZOLI_RS11335	COG0625	glutathione transferase activity
AZOLI_RS11345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AZOLI_RS11355	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AZOLI_RS11365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AZOLI_RS11385	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AZOLI_RS11395	COG4974	Belongs to the 'phage' integrase family
AZOLI_RS11400	COG0840	transmembrane signaling receptor activity
AZOLI_RS11410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AZOLI_RS11425	COG1278	Cold shock
AZOLI_RS11440	COG4191	Histidine kinase
AZOLI_RS11450	COG4106	trans-aconitate 2-methyltransferase activity
AZOLI_RS11465	COG0126	phosphoglycerate kinase activity
AZOLI_RS11480	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AZOLI_RS11485	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AZOLI_RS11495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AZOLI_RS11510	COG0825	malonyl-CoA metabolic process
AZOLI_RS11530	COG2358	TRAP transporter, solute receptor (TAXI family
AZOLI_RS11555	COG2205	protein histidine kinase activity
AZOLI_RS11555	COG2202	Pas domain
AZOLI_RS11570	COG0560	Phosphoserine phosphatase
AZOLI_RS11570	COG3830	Belongs to the UPF0237 family
AZOLI_RS11580	COG1595	DNA-templated transcription, initiation
AZOLI_RS11585	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AZOLI_RS11600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AZOLI_RS11610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AZOLI_RS11625	COG1695	Transcriptional regulator
AZOLI_RS11635	COG0492	ferredoxin-NADP+ reductase activity
AZOLI_RS11640	COG0601	transmembrane transport
AZOLI_RS11645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AZOLI_RS11650	COG0444	Belongs to the ABC transporter superfamily
AZOLI_RS11655	COG4608	Belongs to the ABC transporter superfamily
AZOLI_RS11670	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AZOLI_RS11685	COG0583	DNA-binding transcription factor activity
AZOLI_RS11690	COG0604	alcohol dehydrogenase
AZOLI_RS11700	COG4566	intracellular signal transduction
AZOLI_RS11715	COG0459	protein refolding
AZOLI_RS11720	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AZOLI_RS11725	COG5425	PFAM Usg family protein
AZOLI_RS11735	COG3772	lysozyme
AZOLI_RS11740	COG1612	heme a metabolic process
AZOLI_RS11745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AZOLI_RS11750	COG2217	Heavy metal translocating P-type atpase
AZOLI_RS11775	COG3278	Belongs to the heme-copper respiratory oxidase family
AZOLI_RS11785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AZOLI_RS11805	COG1177	transmembrane transport
AZOLI_RS11825	COG0156	8-amino-7-oxononanoate synthase activity
AZOLI_RS11835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AZOLI_RS11845	COG0135	phosphoribosylanthranilate isomerase activity
AZOLI_RS11860	COG5265	(ABC) transporter
AZOLI_RS11865	COG0840	transmembrane signaling receptor activity
AZOLI_RS11910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AZOLI_RS11920	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AZOLI_RS11930	COG1253	flavin adenine dinucleotide binding
AZOLI_RS11945	COG0583	DNA-binding transcription factor activity
AZOLI_RS11950	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AZOLI_RS11970	COG0138	bifunctional purine biosynthesis protein purh
AZOLI_RS11980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AZOLI_RS11980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AZOLI_RS11990	COG1024	Enoyl-CoA hydratase
AZOLI_RS11995	COG0477	Major facilitator Superfamily
AZOLI_RS12000	COG0583	DNA-binding transcription factor activity
AZOLI_RS12015	COG1272	protein, Hemolysin III
AZOLI_RS12050	COG0137	argininosuccinate synthase activity
AZOLI_RS12070	COG0667	Aldo Keto reductase
AZOLI_RS12100	COG2423	ornithine cyclodeaminase activity
AZOLI_RS12110	COG0776	regulation of translation
AZOLI_RS12125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AZOLI_RS12160	COG0783	Belongs to the Dps family
AZOLI_RS12170	COG0840	transmembrane signaling receptor activity
AZOLI_RS12175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AZOLI_RS12195	COG3335	DDE superfamily endonuclease
AZOLI_RS12270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AZOLI_RS12305	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AZOLI_RS12320	COG3437	response regulator, receiver
AZOLI_RS12320	COG0784	Response regulator, receiver
AZOLI_RS12325	COG3813	Protein conserved in bacteria
AZOLI_RS12330	COG0625	glutathione transferase activity
AZOLI_RS12335	COG1473	amidohydrolase
AZOLI_RS12345	COG5001	Diguanylate cyclase
AZOLI_RS12365	COG4106	trans-aconitate 2-methyltransferase activity
AZOLI_RS12375	COG1040	competence protein
AZOLI_RS12385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AZOLI_RS12405	COG3162	membrane
AZOLI_RS12430	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AZOLI_RS12440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AZOLI_RS12445	COG0542	response to heat
AZOLI_RS12465	COG2890	protein-(glutamine-N5) methyltransferase activity
AZOLI_RS12480	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AZOLI_RS12485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AZOLI_RS12500	COG2070	2-Nitropropane dioxygenase
AZOLI_RS12505	COG0527	aspartate kinase activity
AZOLI_RS12510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AZOLI_RS12520	COG4636	protein conserved in cyanobacteria
AZOLI_RS12525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AZOLI_RS12530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AZOLI_RS12535	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AZOLI_RS12540	COG1137	ATPase activity
AZOLI_RS12555	COG0517	IMP dehydrogenase activity
AZOLI_RS12555	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AZOLI_RS12580	COG2223	nitrite transmembrane transporter activity
AZOLI_RS12620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AZOLI_RS12625	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AZOLI_RS12630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AZOLI_RS12635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AZOLI_RS12645	COG1573	uracil-dna glycosylase
AZOLI_RS12655	COG2154	pterin-4-alpha-carbinolamine dehydratase
AZOLI_RS12660	COG2972	Histidine kinase
AZOLI_RS12660	COG0840	transmembrane signaling receptor activity
AZOLI_RS12665	COG4166	transmembrane transport
AZOLI_RS12670	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AZOLI_RS12685	COG0039	L-malate dehydrogenase activity
AZOLI_RS12695	COG3335	DDE superfamily endonuclease
AZOLI_RS12735	COG0598	Magnesium transport protein CorA
AZOLI_RS12740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AZOLI_RS12745	COG1872	DUF167
AZOLI_RS12765	COG0285	dihydrofolate synthase activity
AZOLI_RS12770	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AZOLI_RS12790	COG0133	tryptophan synthase activity
AZOLI_RS12795	COG2205	protein histidine kinase activity
AZOLI_RS12795	COG0784	Response regulator, receiver
AZOLI_RS12800	COG1278	Cold shock
AZOLI_RS12805	COG2204	response regulator
AZOLI_RS12810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AZOLI_RS12820	COG2205	protein histidine kinase activity
AZOLI_RS12820	COG0784	Response regulator, receiver
AZOLI_RS12820	COG5002	protein histidine kinase activity
AZOLI_RS12835	COG4974	Belongs to the 'phage' integrase family
AZOLI_RS12850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AZOLI_RS12875	COG0271	Belongs to the BolA IbaG family
AZOLI_RS12900	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AZOLI_RS12905	COG0501	Belongs to the peptidase M48B family
AZOLI_RS12920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AZOLI_RS12925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AZOLI_RS12930	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AZOLI_RS12930	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AZOLI_RS12935	COG1660	Displays ATPase and GTPase activities
AZOLI_RS12950	COG0642	Histidine kinase
AZOLI_RS12955	COG0745	RESPONSE REGULATOR receiver
AZOLI_RS12965	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AZOLI_RS13015	COG4957	zinc ion binding
AZOLI_RS13030	COG1214	PFAM Peptidase M22, glycoprotease
AZOLI_RS13035	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AZOLI_RS13055	COG0443	Heat shock 70 kDa protein
AZOLI_RS13080	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AZOLI_RS13085	COG0667	Aldo Keto reductase
AZOLI_RS13100	COG4181	ATPase activity
AZOLI_RS13110	COG0670	Belongs to the BI1 family
AZOLI_RS13120	COG0745	RESPONSE REGULATOR receiver
AZOLI_RS13125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AZOLI_RS13135	COG0573	inorganic phosphate transmembrane transporter activity
AZOLI_RS13140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AZOLI_RS13145	COG5002	protein histidine kinase activity
AZOLI_RS13170	COG0281	malic enzyme
AZOLI_RS13170	COG0280	phosphate acetyltransferase
AZOLI_RS13175	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AZOLI_RS13180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AZOLI_RS13185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AZOLI_RS13190	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AZOLI_RS13205	COG0357	Ribosomal RNA small subunit methyltransferase G
AZOLI_RS13210	COG0445	tRNA wobble uridine modification
AZOLI_RS13230	COG1331	Highly conserved protein containing a thioredoxin domain
AZOLI_RS13245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AZOLI_RS13280	COG1981	membrane
AZOLI_RS13285	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AZOLI_RS13300	COG4395	Tim44
AZOLI_RS13305	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AZOLI_RS13310	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AZOLI_RS13370	COG4235	cytochrome complex assembly
AZOLI_RS13375	COG3088	subunit of a heme lyase
AZOLI_RS13380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AZOLI_RS13385	COG1138	Cytochrome C-type biogenesis protein
AZOLI_RS13390	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AZOLI_RS13400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AZOLI_RS13420	COG1028	Short-chain dehydrogenase reductase Sdr
AZOLI_RS13425	COG1185	polyribonucleotide nucleotidyltransferase activity
AZOLI_RS13430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AZOLI_RS13435	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AZOLI_RS13470	COG0779	Required for maturation of 30S ribosomal subunits
AZOLI_RS13475	COG2329	Antibiotic biosynthesis monooxygenase
AZOLI_RS13480	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AZOLI_RS13485	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AZOLI_RS13490	COG1396	sequence-specific DNA binding
AZOLI_RS13495	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AZOLI_RS13500	COG1253	flavin adenine dinucleotide binding
AZOLI_RS13510	COG1702	phosphate starvation-inducible protein PhoH
AZOLI_RS13515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AZOLI_RS13525	COG2967	ApaG domain
AZOLI_RS13530	COG0302	gtp cyclohydrolase
AZOLI_RS13535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AZOLI_RS13550	COG0668	transmembrane transport
AZOLI_RS13565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AZOLI_RS13580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AZOLI_RS13595	COG0730	response to heat
AZOLI_RS13610	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AZOLI_RS13630	COG1420	regulation of RNA biosynthetic process
AZOLI_RS13640	COG0606	chelatase, subunit chli
AZOLI_RS13660	COG0180	Tryptophanyl-tRNA synthetase
AZOLI_RS13675	COG0792	nuclease activity
AZOLI_RS13680	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AZOLI_RS13710	COG2985	domain, Protein
AZOLI_RS13710	COG0569	domain protein
AZOLI_RS13720	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AZOLI_RS13725	COG0386	Belongs to the glutathione peroxidase family
AZOLI_RS13740	COG0739	heme binding
AZOLI_RS13780	COG0859	PFAM glycosyl transferase family 9
AZOLI_RS13800	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AZOLI_RS13825	COG3118	belongs to the thioredoxin family
AZOLI_RS13830	COG1074	ATP-dependent DNA helicase activity
AZOLI_RS13845	COG2887	Belongs to the helicase family. UvrD subfamily
AZOLI_RS13850	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AZOLI_RS13860	COG0802	atpase or kinase
AZOLI_RS13875	COG0747	negative chemotaxis
AZOLI_RS13885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AZOLI_RS13895	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AZOLI_RS13915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AZOLI_RS13925	COG1024	Enoyl-CoA hydratase
AZOLI_RS14150	COG0495	leucyl-tRNA aminoacylation
AZOLI_RS14500	COG2205	protein histidine kinase activity
AZOLI_RS14550	COG0539	negative regulation of cytoplasmic translation
AZOLI_RS14730	COG0514	ATP-dependent DNA helicase (RecQ)
AZOLI_RS14755	COG1546	Belongs to the CinA family
AZOLI_RS14755	COG1058	Belongs to the CinA family
AZOLI_RS14800	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AZOLI_RS15060	COG2719	SpoVR family
AZOLI_RS15255	COG0247	lactate metabolic process
AZOLI_RS15330	COG2203	Gaf domain
AZOLI_RS15330	COG2199	diguanylate cyclase activity
AZOLI_RS15715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AZOLI_RS15735	COG0049	tRNA binding
AZOLI_RS15745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AZOLI_RS16035	COG0784	Response regulator, receiver
AZOLI_RS16035	COG3437	response regulator, receiver
AZOLI_RS16040	COG3850	Histidine kinase
AZOLI_RS16040	COG4999	Histidine kinase
AZOLI_RS16040	COG2205	protein histidine kinase activity
AZOLI_RS16040	COG3437	response regulator, receiver
AZOLI_RS16915	COG0646	methionine synthase
AZOLI_RS16915	COG1410	methionine synthase
AZOLI_RS17290	COG0484	heat shock protein binding
AZOLI_RS17405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AZOLI_RS17460	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AZOLI_RS17825	COG2814	Major facilitator Superfamily
AZOLI_RS18025	COG2208	phosphoserine phosphatase activity
AZOLI_RS18025	COG2770	Histidine kinase
AZOLI_RS18060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AZOLI_RS18095	COG5001	Diguanylate cyclase
AZOLI_RS18260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AZOLI_RS18270	COG0233	cytoplasmic translational termination
AZOLI_RS18290	COG0750	zinc metalloprotease
AZOLI_RS18320	COG3494	Protein of unknown function (DUF1009)
AZOLI_RS18855	COG0784	Response regulator, receiver
AZOLI_RS18855	COG3437	response regulator, receiver
AZOLI_RS19110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AZOLI_RS19125	COG3300	MHYT domain
AZOLI_RS19125	COG5001	Diguanylate cyclase
AZOLI_RS19450	COG0587	DNA-directed DNA polymerase activity
AZOLI_RS19495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AZOLI_RS19830	COG1454	alcohol dehydrogenase
AZOLI_RS19935	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AZOLI_RS20160	COG0085	RNA polymerase activity
AZOLI_RS20180	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AZOLI_RS20205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AZOLI_RS20345	COG1285	pathogenesis
AZOLI_RS20460	COG0784	Response regulator, receiver
AZOLI_RS20460	COG2205	protein histidine kinase activity
AZOLI_RS20760	COG0166	Belongs to the GPI family
AZOLI_RS20905	COG0235	Class ii aldolase
AZOLI_RS21120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AZOLI_RS21335	COG0022	dehydrogenase e1 component
AZOLI_RS21415	COG0646	methionine synthase
AZOLI_RS21415	COG1410	methionine synthase
AZOLI_RS21550	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AZOLI_RS21550	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AZOLI_RS21890	COG0495	leucyl-tRNA aminoacylation
AZOLI_RS22360	COG0539	negative regulation of cytoplasmic translation
AZOLI_RS22430	COG1643	Atp-dependent helicase
AZOLI_RS22490	COG0567	Dehydrogenase, E1 component
AZOLI_RS22840	COG4166	transmembrane transport
AZOLI_RS23320	COG0085	RNA polymerase activity
AZOLI_RS23605	COG2205	protein histidine kinase activity
AZOLI_RS23605	COG0784	Response regulator, receiver
AZOLI_RS23605	COG5002	protein histidine kinase activity
AZOLI_RS23615	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AZOLI_RS23675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AZOLI_RS23685	COG5001	Diguanylate cyclase
AZOLI_RS23685	COG3300	MHYT domain
AZOLI_RS23905	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AZOLI_RS24035	COG2205	protein histidine kinase activity
AZOLI_RS24035	COG2202	Pas domain
AZOLI_RS24110	COG2154	pterin-4-alpha-carbinolamine dehydratase
AZOLI_RS24485	COG0745	RESPONSE REGULATOR receiver
AZOLI_RS24730	COG0252	asparaginase activity
AZOLI_RS24820	COG1793	dna ligase
AZOLI_RS24820	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AZOLI_RS25180	COG5001	Diguanylate cyclase
AZOLI_RS25180	COG3300	MHYT domain
AZOLI_RS25200	COG0653	protein targeting
AZOLI_RS25460	COG1703	isobutyryl-CoA mutase activity
AZOLI_RS25545	COG2766	serine protein kinase
AZOLI_RS25835	COG2171	N-acyltransferase activity
AZOLI_RS26175	COG0085	RNA polymerase activity
AZOLI_RS26225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AZOLI_RS26335	COG2199	diguanylate cyclase activity
AZOLI_RS26335	COG2200	EAL domain
AZOLI_RS26335	COG2203	Gaf domain
AZOLI_RS26820	COG0612	Peptidase, M16
AZOLI_RS26925	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AZOLI_RS26940	COG0840	transmembrane signaling receptor activity
AZOLI_RS27105	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AZOLI_RS27385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AZOLI_RS27625	COG0297	glycogen (starch) synthase activity
AZOLI_RS27715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AZOLI_RS27765	COG2205	protein histidine kinase activity
AZOLI_RS27830	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AZOLI_RS27890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AZOLI_RS27940	COG1643	Atp-dependent helicase
AZOLI_RS27945	COG1643	Atp-dependent helicase
AZOLI_RS28265	COG4239	(ABC) transporter, permease
AZOLI_RS28275	COG4166	transmembrane transport
AZOLI_RS28445	COG0840	transmembrane signaling receptor activity
AZOLI_RS29135	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AZOLI_RS29395	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AZOLI_RS29650	COG2205	protein histidine kinase activity
AZOLI_RS30265	COG1295	ribonuclease BN
AZOLI_RS30275	COG0745	RESPONSE REGULATOR receiver
AZOLI_RS30370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AZOLI_RS30460	COG0584	glycerophosphoryl diester phosphodiesterase
AZOLI_RS30670	COG4251	negative regulation of phosphorylation