locus-tag	class	description
HUE56_RS00010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUE56_RS00020	COG1091	dTDP-4-dehydrorhamnose reductase activity
HUE56_RS00025	COG1088	dTDP-glucose 4,6-dehydratase activity
HUE56_RS00030	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HUE56_RS00035	COG0438	transferase activity, transferring glycosyl groups
HUE56_RS00035	COG1216	Glycosyl transferase, family 2
HUE56_RS00055	COG0175	sulfate reduction
HUE56_RS00065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HUE56_RS00070	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HUE56_RS00085	COG0457	Tetratricopeptide repeat
HUE56_RS00085	COG0859	PFAM glycosyl transferase family 9
HUE56_RS00100	COG2321	neutral zinc metallopeptidase
HUE56_RS00110	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUE56_RS00120	COG1686	Belongs to the peptidase S11 family
HUE56_RS00125	COG0784	Response regulator, receiver
HUE56_RS00125	COG4191	Histidine kinase
HUE56_RS00130	COG0789	Transcriptional regulator
HUE56_RS00140	COG2217	Heavy metal translocating P-type atpase
HUE56_RS00160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUE56_RS00175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUE56_RS00205	COG0784	Response regulator, receiver
HUE56_RS00205	COG4191	Histidine kinase
HUE56_RS00230	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUE56_RS00265	COG1192	Involved in chromosome partitioning
HUE56_RS00285	COG0438	transferase activity, transferring glycosyl groups
HUE56_RS00290	COG2264	protein methyltransferase activity
HUE56_RS00295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUE56_RS00305	COG0463	Glycosyl transferase, family 2
HUE56_RS00325	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUE56_RS00340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUE56_RS00345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUE56_RS00365	COG1216	Glycosyl transferase, family 2
HUE56_RS00370	COG1216	Glycosyl transferase, family 2
HUE56_RS00370	COG0438	transferase activity, transferring glycosyl groups
HUE56_RS00400	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HUE56_RS00410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUE56_RS00415	COG2226	methyltransferase
HUE56_RS00435	COG0438	transferase activity, transferring glycosyl groups
HUE56_RS00465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUE56_RS00485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUE56_RS00520	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HUE56_RS00535	COG0438	transferase activity, transferring glycosyl groups
HUE56_RS00535	COG1216	Glycosyl transferase, family 2
HUE56_RS00575	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUE56_RS00640	COG3206	protein involved in exopolysaccharide biosynthesis
HUE56_RS00640	COG0489	protein tyrosine kinase activity
HUE56_RS00675	COG0438	transferase activity, transferring glycosyl groups
HUE56_RS00685	COG1132	(ABC) transporter
HUE56_RS00775	COG0438	transferase activity, transferring glycosyl groups
HUE56_RS00780	COG0438	transferase activity, transferring glycosyl groups
HUE56_RS00790	COG4520	surface antigen
HUE56_RS00795	COG0494	nUDIX hydrolase
HUE56_RS00820	COG0022	dehydrogenase e1 component
HUE56_RS00820	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUE56_RS00825	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUE56_RS00830	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUE56_RS00835	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUE56_RS00840	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUE56_RS00840	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUE56_RS00845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUE56_RS00860	COG2192	nodulation
HUE56_RS00900	COG1032	radical SAM domain protein
HUE56_RS00915	COG2192	nodulation
HUE56_RS00935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUE56_RS00990	COG4638	Rieske (2fe-2S)
HUE56_RS01070	COG4106	trans-aconitate 2-methyltransferase activity
HUE56_RS01090	COG2818	Glycosylase
HUE56_RS01155	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUE56_RS01160	COG1086	Polysaccharide biosynthesis protein
HUE56_RS01200	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HUE56_RS01200	COG0662	Cupin 2, conserved barrel domain protein
HUE56_RS01210	COG2274	protein secretion by the type I secretion system
HUE56_RS01215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUE56_RS01230	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUE56_RS01230	COG1024	Enoyl-CoA hydratase
HUE56_RS01235	COG0183	Belongs to the thiolase family
HUE56_RS01270	COG2373	Large extracellular alpha-helical protein
HUE56_RS01310	COG3273	potassium ion transport
HUE56_RS01310	COG0471	metal ion transport
HUE56_RS01345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUE56_RS01355	COG1012	belongs to the aldehyde dehydrogenase family
HUE56_RS01360	COG1917	Cupin 2, conserved barrel domain protein
HUE56_RS01360	COG1396	sequence-specific DNA binding
HUE56_RS01370	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUE56_RS01375	COG2182	Extracellular solute-binding protein
HUE56_RS01380	COG3842	ATPase activity
HUE56_RS01385	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HUE56_RS01405	COG0583	DNA-binding transcription factor activity
HUE56_RS01425	COG1196	nuclear chromosome segregation
HUE56_RS01425	COG0741	lytic transglycosylase activity
HUE56_RS01425	COG0739	heme binding
HUE56_RS01445	COG2723	6-phospho-beta-galactosidase activity
HUE56_RS01455	COG2188	Transcriptional regulator
HUE56_RS01460	COG1228	amidohydrolase
HUE56_RS01465	COG0402	S-adenosylhomocysteine deaminase activity
HUE56_RS01470	COG2986	histidine ammonia-lyase
HUE56_RS01540	COG4336	lyase activity
HUE56_RS01550	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HUE56_RS01555	COG1984	allophanate hydrolase subunit 2
HUE56_RS01565	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HUE56_RS01580	COG1104	cysteine desulfurase activity
HUE56_RS01595	COG0795	lipopolysaccharide-transporting ATPase activity
HUE56_RS01620	COG5002	protein histidine kinase activity
HUE56_RS01630	COG0745	RESPONSE REGULATOR receiver
HUE56_RS01660	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HUE56_RS01705	COG0697	spore germination
HUE56_RS01725	COG0542	response to heat
HUE56_RS01735	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS01770	COG1360	Flagellar Motor Protein
HUE56_RS01785	COG3501	Rhs element vgr protein
HUE56_RS01815	COG0583	DNA-binding transcription factor activity
HUE56_RS01820	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUE56_RS01825	COG0435	Glutathione S-transferase
HUE56_RS01855	COG0408	coproporphyrinogen oxidase activity
HUE56_RS01860	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HUE56_RS01885	COG2198	Histidine kinase
HUE56_RS01885	COG0643	Histidine kinase
HUE56_RS01885	COG0784	Response regulator, receiver
HUE56_RS01890	COG3706	GGDEF domain
HUE56_RS01900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUE56_RS01905	COG4770	biotin carboxylase activity
HUE56_RS01910	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUE56_RS01910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUE56_RS01920	COG2095	MarC family integral membrane protein
HUE56_RS01940	COG1271	oxidase subunit
HUE56_RS01945	COG1294	oxidase, subunit
HUE56_RS01955	COG2080	2 iron, 2 sulfur cluster binding
HUE56_RS01970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUE56_RS01975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUE56_RS01980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUE56_RS01990	COG0356	it plays a direct role in the translocation of protons across the membrane
HUE56_RS02010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUE56_RS02020	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUE56_RS02030	COG1012	belongs to the aldehyde dehydrogenase family
HUE56_RS02035	COG0028	Belongs to the TPP enzyme family
HUE56_RS02045	COG4178	(ABC) transporter
HUE56_RS02050	COG0154	amidase activity
HUE56_RS02080	COG5002	protein histidine kinase activity
HUE56_RS02080	COG5001	Diguanylate cyclase
HUE56_RS02100	COG0640	Transcriptional regulator
HUE56_RS02115	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUE56_RS02130	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUE56_RS02140	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HUE56_RS02145	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HUE56_RS02170	COG0583	DNA-binding transcription factor activity
HUE56_RS02175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUE56_RS02180	COG1522	sequence-specific DNA binding
HUE56_RS02185	COG4172	Belongs to the ABC transporter superfamily
HUE56_RS02190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUE56_RS02195	COG0601	transmembrane transport
HUE56_RS02200	COG0747	negative chemotaxis
HUE56_RS02215	COG0454	-acetyltransferase
HUE56_RS02225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUE56_RS02240	COG1012	belongs to the aldehyde dehydrogenase family
HUE56_RS02250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUE56_RS02270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUE56_RS02300	COG0659	secondary active sulfate transmembrane transporter activity
HUE56_RS02315	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HUE56_RS02320	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUE56_RS02330	COG0784	Response regulator, receiver
HUE56_RS02330	COG5002	protein histidine kinase activity
HUE56_RS02360	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HUE56_RS02375	COG0183	Belongs to the thiolase family
HUE56_RS02380	COG0318	PFAM AMP-dependent synthetase and ligase
HUE56_RS02385	COG1268	BioY protein
HUE56_RS02390	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HUE56_RS02395	COG1122	ATPase activity
HUE56_RS02400	COG2161	toxin-antitoxin pair type II binding
HUE56_RS02405	COG4115	mRNA cleavage
HUE56_RS02410	COG1126	abc transporter atp-binding protein
HUE56_RS02420	COG0765	amino acid transport
HUE56_RS02430	COG2188	Transcriptional regulator
HUE56_RS02435	COG2995	paraquat-inducible protein a
HUE56_RS02440	COG3008	intermembrane lipid transfer
HUE56_RS02455	COG0022	dehydrogenase e1 component
HUE56_RS02460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUE56_RS02465	COG1174	glycine betaine transport
HUE56_RS02470	COG1125	glycine betaine transport
HUE56_RS02475	COG1174	glycine betaine transport
HUE56_RS02480	COG1732	Glycine betaine
HUE56_RS02490	COG1335	isochorismatase
HUE56_RS02510	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HUE56_RS02540	COG1737	Transcriptional regulator
HUE56_RS02550	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUE56_RS02590	COG4566	intracellular signal transduction
HUE56_RS02610	COG0028	Belongs to the TPP enzyme family
HUE56_RS02615	COG0745	RESPONSE REGULATOR receiver
HUE56_RS02620	COG2205	protein histidine kinase activity
HUE56_RS02625	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HUE56_RS02635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUE56_RS02640	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS02645	COG1755	Isoprenylcysteine carboxyl methyltransferase
HUE56_RS02655	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HUE56_RS02670	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HUE56_RS02680	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HUE56_RS02690	COG2204	response regulator
HUE56_RS02695	COG0375	protein maturation
HUE56_RS02760	COG1566	PFAM secretion protein HlyD family protein
HUE56_RS02770	COG3956	TIGRFAM MazG family protein
HUE56_RS02790	COG1233	COG1233 Phytoene dehydrogenase and related
HUE56_RS02800	COG1012	belongs to the aldehyde dehydrogenase family
HUE56_RS02810	COG1960	acyl-CoA dehydrogenase activity
HUE56_RS02815	COG0318	PFAM AMP-dependent synthetase and ligase
HUE56_RS02830	COG3180	Ammonia monooxygenase
HUE56_RS02845	COG2132	Multicopper oxidase
HUE56_RS02865	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HUE56_RS02870	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HUE56_RS02875	COG0583	DNA-binding transcription factor activity
HUE56_RS02910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUE56_RS02910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUE56_RS02915	COG1105	Belongs to the carbohydrate kinase PfkB family
HUE56_RS02920	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUE56_RS02920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUE56_RS02925	COG1609	Transcriptional regulator
HUE56_RS02945	COG0489	protein tyrosine kinase activity
HUE56_RS02945	COG3206	protein involved in exopolysaccharide biosynthesis
HUE56_RS02965	COG0438	transferase activity, transferring glycosyl groups
HUE56_RS02980	COG0438	transferase activity, transferring glycosyl groups
HUE56_RS03000	COG2116	formate transmembrane transporter activity
HUE56_RS03005	COG2815	serine threonine protein kinase
HUE56_RS03005	COG0515	serine threonine protein kinase
HUE56_RS03015	COG1131	(ABC) transporter
HUE56_RS03035	COG0366	Alpha amylase catalytic
HUE56_RS03045	COG0066	3-isopropylmalate dehydratase activity
HUE56_RS03050	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUE56_RS03055	COG3976	FMN-binding domain protein
HUE56_RS03055	COG1053	succinate dehydrogenase
HUE56_RS03060	COG1335	isochorismatase
HUE56_RS03105	COG2188	Transcriptional regulator
HUE56_RS03120	COG0459	protein refolding
HUE56_RS03145	COG3474	cytochrome
HUE56_RS03150	COG0346	lactoylglutathione lyase activity
HUE56_RS03170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUE56_RS03175	COG2084	Dehydrogenase
HUE56_RS03185	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUE56_RS03190	COG3958	Transketolase
HUE56_RS03195	COG3959	Transketolase, thiamine diphosphate binding domain
HUE56_RS03200	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS03205	COG0583	DNA-binding transcription factor activity
HUE56_RS03215	COG0668	transmembrane transport
HUE56_RS03220	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HUE56_RS03245	COG2207	Transcriptional regulator
HUE56_RS03260	COG1566	PFAM secretion protein HlyD family protein
HUE56_RS03265	COG0318	PFAM AMP-dependent synthetase and ligase
HUE56_RS03280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUE56_RS03285	COG1024	Enoyl-CoA hydratase
HUE56_RS03310	COG2814	Major facilitator Superfamily
HUE56_RS03315	COG2207	Transcriptional regulator
HUE56_RS03320	COG1522	sequence-specific DNA binding
HUE56_RS03325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUE56_RS03325	COG2010	Cytochrome c
HUE56_RS03330	COG2080	2 iron, 2 sulfur cluster binding
HUE56_RS03335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUE56_RS03335	COG2010	Cytochrome c
HUE56_RS03400	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUE56_RS03415	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HUE56_RS03420	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUE56_RS03425	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS03430	COG1959	2 iron, 2 sulfur cluster binding
HUE56_RS03435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUE56_RS03440	COG1475	DNA binding
HUE56_RS03445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUE56_RS03480	COG1959	2 iron, 2 sulfur cluster binding
HUE56_RS03485	COG0719	Fe-S assembly protein
HUE56_RS03490	COG0396	ATPase activity
HUE56_RS03495	COG0719	Fe-S assembly protein
HUE56_RS03500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUE56_RS03505	COG0822	iron-sulfur transferase activity
HUE56_RS03510	COG2151	metal-sulfur cluster biosynthetic enzyme
HUE56_RS03515	COG0316	Belongs to the HesB IscA family
HUE56_RS03520	COG1741	Belongs to the pirin family
HUE56_RS03540	COG1414	Transcriptional regulator
HUE56_RS03545	COG3734	2-keto-3-deoxy-galactonokinase
HUE56_RS03550	COG0800	Aldolase
HUE56_RS03570	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS03575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUE56_RS03580	COG1942	4-Oxalocrotonate Tautomerase
HUE56_RS03585	COG0583	DNA-binding transcription factor activity
HUE56_RS03595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUE56_RS03605	COG0837	glucose binding
HUE56_RS03605	COG1737	Transcriptional regulator
HUE56_RS03610	COG1882	Formate acetyltransferase
HUE56_RS03615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HUE56_RS03630	COG1609	Transcriptional regulator
HUE56_RS03640	COG0246	Mannitol dehydrogenase
HUE56_RS03645	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUE56_RS03645	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUE56_RS03645	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUE56_RS03650	COG2271	Major facilitator Superfamily
HUE56_RS03660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUE56_RS03680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUE56_RS03695	COG2197	response regulator
HUE56_RS03700	COG2205	protein histidine kinase activity
HUE56_RS03705	COG0243	molybdopterin cofactor binding
HUE56_RS03715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUE56_RS03715	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUE56_RS03745	COG5002	protein histidine kinase activity
HUE56_RS03770	COG1177	transmembrane transport
HUE56_RS03775	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUE56_RS03780	COG3842	ATPase activity
HUE56_RS03790	COG0535	radical SAM domain protein
HUE56_RS03810	COG2076	Multidrug Resistance protein
HUE56_RS03815	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUE56_RS03815	COG0546	phosphoglycolate phosphatase activity
HUE56_RS03820	COG0174	glutamine synthetase
HUE56_RS03825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUE56_RS03835	COG0513	Belongs to the DEAD box helicase family
HUE56_RS03845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUE56_RS03850	COG1199	ATP-dependent helicase activity
HUE56_RS03850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUE56_RS03855	COG0679	Auxin Efflux Carrier
HUE56_RS03865	COG2084	Dehydrogenase
HUE56_RS03875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUE56_RS03885	COG1196	nuclear chromosome segregation
HUE56_RS03890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUE56_RS03920	COG3047	cAMP biosynthetic process
HUE56_RS03930	COG2197	response regulator
HUE56_RS03935	COG1309	transcriptional regulator
HUE56_RS03940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUE56_RS03950	COG2721	sulfolactate sulfo-lyase activity
HUE56_RS03955	COG1904	glucuronate isomerase
HUE56_RS03960	COG1802	Transcriptional regulator
HUE56_RS03965	COG1917	Cupin 2, conserved barrel domain protein
HUE56_RS03970	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS03975	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HUE56_RS03980	COG1803	Methylglyoxal synthase
HUE56_RS03985	COG1802	Transcriptional regulator
HUE56_RS03995	COG2274	protein secretion by the type I secretion system
HUE56_RS04000	COG2274	protein secretion by the type I secretion system
HUE56_RS04015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUE56_RS04020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUE56_RS04040	COG0183	Belongs to the thiolase family
HUE56_RS04045	COG2050	protein possibly involved in aromatic compounds catabolism
HUE56_RS04050	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUE56_RS04055	COG1024	Enoyl-CoA hydratase
HUE56_RS04065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUE56_RS04070	COG2151	metal-sulfur cluster biosynthetic enzyme
HUE56_RS04075	COG3396	Phenylacetate-CoA oxygenase
HUE56_RS04080	COG3460	Phenylacetate-CoA oxygenase
HUE56_RS04085	COG3396	Phenylacetate-CoA oxygenase
HUE56_RS04095	COG0693	protein deglycase activity
HUE56_RS04100	COG2224	Isocitrate lyase
HUE56_RS04105	COG1396	sequence-specific DNA binding
HUE56_RS04105	COG3800	Transcriptional regulator
HUE56_RS04120	COG1280	lysine exporter protein (LysE YggA)
HUE56_RS04125	COG3437	response regulator, receiver
HUE56_RS04125	COG0784	Response regulator, receiver
HUE56_RS04130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUE56_RS04140	COG1121	(ABC) transporter
HUE56_RS04145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUE56_RS04155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUE56_RS04165	COG0347	Belongs to the P(II) protein family
HUE56_RS04170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUE56_RS04220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUE56_RS04230	COG2205	protein histidine kinase activity
HUE56_RS04230	COG0784	Response regulator, receiver
HUE56_RS04230	COG2198	Histidine kinase
HUE56_RS04240	COG1764	response to oxidative stress
HUE56_RS04245	COG0019	diaminopimelate decarboxylase activity
HUE56_RS04260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUE56_RS04265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUE56_RS04265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUE56_RS04275	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HUE56_RS04285	COG1131	(ABC) transporter
HUE56_RS04310	COG3206	protein involved in exopolysaccharide biosynthesis
HUE56_RS04310	COG0489	protein tyrosine kinase activity
HUE56_RS04320	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HUE56_RS04330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUE56_RS04345	COG0438	transferase activity, transferring glycosyl groups
HUE56_RS04350	COG1522	sequence-specific DNA binding
HUE56_RS04380	COG3093	addiction module antidote protein HigA
HUE56_RS04440	COG3436	PFAM IS66 Orf2 family protein
HUE56_RS04445	COG4372	Transposase
HUE56_RS04465	COG3436	PFAM IS66 Orf2 family protein
HUE56_RS04640	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HUE56_RS04650	COG3012	SEC-C Motif Domain Protein
HUE56_RS04655	COG1278	Cold shock
HUE56_RS04700	COG0583	DNA-binding transcription factor activity
HUE56_RS04745	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUE56_RS04805	COG2099	Precorrin-6x reductase
HUE56_RS04835	COG1797	cobyrinic acid a,c-diamide synthase activity
HUE56_RS04840	COG0778	Nitroreductase
HUE56_RS04850	COG2198	Histidine kinase
HUE56_RS04850	COG0643	Histidine kinase
HUE56_RS04860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HUE56_RS04870	COG2201	protein-glutamate methylesterase activity
HUE56_RS04875	COG0835	chemotaxis
HUE56_RS04880	COG0840	transmembrane signaling receptor activity
HUE56_RS04885	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUE56_RS04885	COG1776	CheC inhibitor of MCP methylation
HUE56_RS04890	COG2201	protein-glutamate methylesterase activity
HUE56_RS04895	COG0859	PFAM glycosyl transferase family 9
HUE56_RS04895	COG0457	Tetratricopeptide repeat
HUE56_RS04900	COG1464	Belongs to the NlpA lipoprotein family
HUE56_RS04905	COG2011	ABC-type metal ion transport system permease component
HUE56_RS04910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUE56_RS04930	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUE56_RS04940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUE56_RS04970	COG1530	ribonuclease E activity
HUE56_RS04975	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HUE56_RS04990	COG1045	serine acetyltransferase
HUE56_RS05005	COG0287	Prephenate dehydrogenase
HUE56_RS05010	COG0583	DNA-binding transcription factor activity
HUE56_RS05025	COG1971	Probably functions as a manganese efflux pump
HUE56_RS05030	COG0402	S-adenosylhomocysteine deaminase activity
HUE56_RS05040	COG1309	transcriptional regulator
HUE56_RS05045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUE56_RS05050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUE56_RS05075	COG0784	Response regulator, receiver
HUE56_RS05085	COG3214	Protein conserved in bacteria
HUE56_RS05090	COG1522	sequence-specific DNA binding
HUE56_RS05095	COG0586	Pfam SNARE associated Golgi protein
HUE56_RS05110	COG0427	acetyl-CoA hydrolase
HUE56_RS05125	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUE56_RS05130	COG2202	Pas domain
HUE56_RS05130	COG2205	protein histidine kinase activity
HUE56_RS05145	COG1012	belongs to the aldehyde dehydrogenase family
HUE56_RS05150	COG2864	formate dehydrogenase
HUE56_RS05155	COG0437	4 iron, 4 sulfur cluster binding
HUE56_RS05160	COG3383	formate dehydrogenase (NAD+) activity
HUE56_RS05160	COG0243	molybdopterin cofactor binding
HUE56_RS05185	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUE56_RS05205	COG4948	Mandelate Racemase Muconate Lactonizing
HUE56_RS05210	COG0583	DNA-binding transcription factor activity
HUE56_RS05240	COG0745	RESPONSE REGULATOR receiver
HUE56_RS05245	COG1278	Cold shock
HUE56_RS05270	COG2198	Histidine kinase
HUE56_RS05270	COG0784	Response regulator, receiver
HUE56_RS05270	COG0643	Histidine kinase
HUE56_RS05275	COG0835	chemotaxis
HUE56_RS05280	COG0643	Histidine kinase
HUE56_RS05280	COG2198	Histidine kinase
HUE56_RS05280	COG0784	Response regulator, receiver
HUE56_RS05300	COG2205	protein histidine kinase activity
HUE56_RS05315	COG3920	Histidine kinase
HUE56_RS05325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUE56_RS05340	COG0531	amino acid
HUE56_RS05350	COG4303	Ethanolamine ammonia lyase large subunit
HUE56_RS05370	COG1280	lysine exporter protein (LysE YggA)
HUE56_RS05390	COG2233	PERMEase
HUE56_RS05400	COG2723	6-phospho-beta-galactosidase activity
HUE56_RS05430	COG1295	ribonuclease BN
HUE56_RS05440	COG0861	Integral membrane protein TerC family
HUE56_RS05475	COG0793	Belongs to the peptidase S41A family
HUE56_RS05485	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUE56_RS05490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUE56_RS05495	COG0671	phosphoesterase, PA-phosphatase related
HUE56_RS05510	COG0848	biopolymer transport protein
HUE56_RS05525	COG4221	oxidoreductase activity
HUE56_RS05540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUE56_RS05550	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HUE56_RS05555	COG1595	DNA-templated transcription, initiation
HUE56_RS05560	COG3806	Anti-sigma factor
HUE56_RS05575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE56_RS05580	COG4597	amino acid ABC transporter
HUE56_RS05585	COG0765	amino acid transport
HUE56_RS05590	COG1126	abc transporter atp-binding protein
HUE56_RS05605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE56_RS05630	COG0683	leucine binding
HUE56_RS05635	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HUE56_RS05640	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HUE56_RS05645	COG0183	Belongs to the thiolase family
HUE56_RS05650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUE56_RS05655	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUE56_RS05665	COG3485	protocatechuate 3,4-dioxygenase
HUE56_RS05670	COG3485	protocatechuate 3,4-dioxygenase
HUE56_RS05675	COG0840	transmembrane signaling receptor activity
HUE56_RS05680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUE56_RS05685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HUE56_RS05695	COG3265	gluconokinase activity
HUE56_RS05700	COG1609	Transcriptional regulator
HUE56_RS05705	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HUE56_RS05710	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HUE56_RS05720	COG0842	Transport permease protein
HUE56_RS05720	COG1129	ABC transporter
HUE56_RS05725	COG0842	Transport permease protein
HUE56_RS05735	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUE56_RS05745	COG0564	pseudouridine synthase activity
HUE56_RS05800	COG1566	PFAM secretion protein HlyD family protein
HUE56_RS05810	COG0129	dihydroxy-acid dehydratase activity
HUE56_RS05815	COG1672	PFAM Archaeal ATPase
HUE56_RS05815	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUE56_RS05850	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS05855	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HUE56_RS05860	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HUE56_RS05865	COG2610	gluconate transmembrane transporter activity
HUE56_RS05870	COG2217	Heavy metal translocating P-type atpase
HUE56_RS05890	COG2884	Cell division ATP-binding protein ftsE
HUE56_RS05895	COG0318	PFAM AMP-dependent synthetase and ligase
HUE56_RS05895	COG0204	Acyl-transferase
HUE56_RS05955	COG2814	Major facilitator Superfamily
HUE56_RS05960	COG0667	Aldo Keto reductase
HUE56_RS06000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE56_RS06005	COG0765	amino acid transport
HUE56_RS06025	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HUE56_RS06050	COG0588	phosphoglycerate mutase activity
HUE56_RS06055	COG0438	transferase activity, transferring glycosyl groups
HUE56_RS06070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUE56_RS06075	COG0601	transmembrane transport
HUE56_RS06100	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HUE56_RS06135	COG1960	acyl-CoA dehydrogenase activity
HUE56_RS06145	COG1192	Involved in chromosome partitioning
HUE56_RS06150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUE56_RS06155	COG0667	Aldo Keto reductase
HUE56_RS06325	COG1396	sequence-specific DNA binding
HUE56_RS06350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUE56_RS06360	COG1522	sequence-specific DNA binding
HUE56_RS06390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUE56_RS06430	COG0583	DNA-binding transcription factor activity
HUE56_RS06435	COG0667	Aldo Keto reductase
HUE56_RS06445	COG0501	Belongs to the peptidase M48B family
HUE56_RS06450	COG0586	Pfam SNARE associated Golgi protein
HUE56_RS06455	COG0587	DNA-directed DNA polymerase activity
HUE56_RS06480	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS06485	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUE56_RS06490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUE56_RS06540	COG1432	Conserved Protein
HUE56_RS06550	COG0675	Transposase, IS605 OrfB family
HUE56_RS06555	COG0675	Transposase, IS605 OrfB family
HUE56_RS06605	COG0564	pseudouridine synthase activity
HUE56_RS06650	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS06655	COG0840	transmembrane signaling receptor activity
HUE56_RS06655	COG2972	Histidine kinase
HUE56_RS06685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUE56_RS06690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUE56_RS06695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUE56_RS06700	COG4774	siderophore transport
HUE56_RS06725	COG4585	Histidine kinase
HUE56_RS06760	COG0277	FAD linked oxidase domain protein
HUE56_RS06770	COG3842	ATPase activity
HUE56_RS06775	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUE56_RS06780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUE56_RS06800	COG2918	glutathione biosynthetic process
HUE56_RS06800	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUE56_RS06820	COG0840	transmembrane signaling receptor activity
HUE56_RS06850	COG0686	Belongs to the AlaDH PNT family
HUE56_RS06855	COG1522	sequence-specific DNA binding
HUE56_RS06860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUE56_RS06870	COG1280	lysine exporter protein (LysE YggA)
HUE56_RS06880	COG2205	protein histidine kinase activity
HUE56_RS06880	COG2198	Histidine kinase
HUE56_RS06880	COG0784	Response regulator, receiver
HUE56_RS06910	COG0306	phosphate transporter
HUE56_RS06920	COG2205	protein histidine kinase activity
HUE56_RS06920	COG2202	Pas domain
HUE56_RS06940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUE56_RS06985	COG0405	Gamma-glutamyltransferase
HUE56_RS07005	COG2204	response regulator
HUE56_RS07030	COG2814	Major facilitator Superfamily
HUE56_RS07045	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HUE56_RS07060	COG2084	Dehydrogenase
HUE56_RS07065	COG3622	Belongs to the hyi family
HUE56_RS07070	COG1902	pentaerythritol trinitrate reductase activity
HUE56_RS07070	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUE56_RS07075	COG1802	Transcriptional regulator
HUE56_RS07085	COG0861	Integral membrane protein TerC family
HUE56_RS07090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUE56_RS07100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HUE56_RS07115	COG1309	transcriptional regulator
HUE56_RS07140	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS07160	COG4615	Cyclic peptide transporter
HUE56_RS07165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUE56_RS07190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUE56_RS07250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUE56_RS07255	COG0583	DNA-binding transcription factor activity
HUE56_RS07275	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUE56_RS07290	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS07295	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS07305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUE56_RS07330	COG0513	Belongs to the DEAD box helicase family
HUE56_RS07365	COG1475	DNA binding
HUE56_RS07370	COG1192	Involved in chromosome partitioning
HUE56_RS07380	COG4626	Terminase
HUE56_RS07380	COG1802	Transcriptional regulator
HUE56_RS07395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUE56_RS07405	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS07410	COG0534	Mate efflux family protein
HUE56_RS07415	COG1309	transcriptional regulator
HUE56_RS07430	COG1850	ribulose-bisphosphate carboxylase activity
HUE56_RS07440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUE56_RS07460	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS07505	COG3842	ATPase activity
HUE56_RS07525	COG1475	DNA binding
HUE56_RS07530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUE56_RS07535	COG4221	oxidoreductase activity
HUE56_RS07545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUE56_RS07555	COG4521	taurine ABC transporter
HUE56_RS07560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUE56_RS07595	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HUE56_RS07615	COG0583	DNA-binding transcription factor activity
HUE56_RS07625	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS07630	COG4221	oxidoreductase activity
HUE56_RS07630	COG4221	oxidoreductase activity
HUE56_RS07640	COG2814	Major facilitator Superfamily
HUE56_RS07650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUE56_RS07660	COG2198	Histidine kinase
HUE56_RS07660	COG0784	Response regulator, receiver
HUE56_RS07660	COG5002	protein histidine kinase activity
HUE56_RS07700	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUE56_RS07705	COG1312	Catalyzes the dehydration of D-mannonate
HUE56_RS07710	COG0246	Mannitol dehydrogenase
HUE56_RS07720	COG0583	DNA-binding transcription factor activity
HUE56_RS07740	COG1012	belongs to the aldehyde dehydrogenase family
HUE56_RS07755	COG0431	NADPH-dependent FMN reductase
HUE56_RS07755	COG1053	succinate dehydrogenase
HUE56_RS07755	COG3976	FMN-binding domain protein
HUE56_RS07775	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUE56_RS07790	COG2086	electron transfer activity
HUE56_RS07800	COG0183	Belongs to the thiolase family
HUE56_RS07810	COG0402	S-adenosylhomocysteine deaminase activity
HUE56_RS07835	COG0601	transmembrane transport
HUE56_RS07840	COG0747	negative chemotaxis
HUE56_RS07850	COG0583	DNA-binding transcription factor activity
HUE56_RS07870	COG0714	Associated with various cellular activities
HUE56_RS07890	COG4589	Belongs to the CDS family
HUE56_RS07900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUE56_RS07900	COG1213	nucleotidyl transferase
HUE56_RS07925	COG0754	glutathionylspermidine amidase activity
HUE56_RS07935	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUE56_RS07945	COG1051	belongs to the nudix hydrolase family
HUE56_RS07945	COG1056	cytidyltransferase-related domain
HUE56_RS07950	COG2207	Transcriptional regulator
HUE56_RS07950	COG1917	Cupin 2, conserved barrel domain protein
HUE56_RS07975	COG1024	Enoyl-CoA hydratase
HUE56_RS08005	COG1309	transcriptional regulator
HUE56_RS08010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUE56_RS08015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HUE56_RS08020	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HUE56_RS08025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUE56_RS08030	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUE56_RS08045	COG3119	arylsulfatase activity
HUE56_RS08085	COG0747	negative chemotaxis
HUE56_RS08090	COG4172	Belongs to the ABC transporter superfamily
HUE56_RS08115	COG3712	iron ion homeostasis
HUE56_RS08130	COG1959	2 iron, 2 sulfur cluster binding
HUE56_RS08150	COG1959	2 iron, 2 sulfur cluster binding
HUE56_RS08155	COG0596	Alpha beta hydrolase
HUE56_RS08170	COG2205	protein histidine kinase activity
HUE56_RS08175	COG0745	RESPONSE REGULATOR receiver
HUE56_RS08185	COG0785	Cytochrome C biogenesis protein
HUE56_RS08185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUE56_RS08190	COG1846	Transcriptional regulator
HUE56_RS08215	COG2113	Glycine betaine
HUE56_RS08220	COG4176	ABC-type proline glycine betaine transport system permease component
HUE56_RS08240	COG0596	Alpha beta hydrolase
HUE56_RS08245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUE56_RS08250	COG1012	belongs to the aldehyde dehydrogenase family
HUE56_RS08270	COG0840	transmembrane signaling receptor activity
HUE56_RS08275	COG2271	Major facilitator Superfamily
HUE56_RS08280	COG1335	isochorismatase
HUE56_RS08285	COG3473	Maleate cis-trans isomerase
HUE56_RS08290	COG0596	Alpha beta hydrolase
HUE56_RS08295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUE56_RS08300	COG2309	aminopeptidase activity
HUE56_RS08305	COG1846	Transcriptional regulator
HUE56_RS08310	COG2080	2 iron, 2 sulfur cluster binding
HUE56_RS08315	COG2010	Cytochrome c
HUE56_RS08315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUE56_RS08325	COG1131	(ABC) transporter
HUE56_RS08330	COG0842	Transport permease protein
HUE56_RS08355	COG0183	Belongs to the thiolase family
HUE56_RS08360	COG2031	fatty acid transporter
HUE56_RS08365	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HUE56_RS08370	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HUE56_RS08375	COG2204	response regulator
HUE56_RS08380	COG3852	Histidine kinase
HUE56_RS08395	COG0784	Response regulator, receiver
HUE56_RS08400	COG2201	protein-glutamate methylesterase activity
HUE56_RS08420	COG1609	Transcriptional regulator
HUE56_RS08430	COG2271	Major facilitator Superfamily
HUE56_RS08465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUE56_RS08475	COG3239	Fatty acid desaturase
HUE56_RS08485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUE56_RS08490	COG0583	DNA-binding transcription factor activity
HUE56_RS08495	COG3608	succinylglutamate desuccinylase aspartoacylase
HUE56_RS08500	COG0747	negative chemotaxis
HUE56_RS08505	COG0601	transmembrane transport
HUE56_RS08515	COG0444	Belongs to the ABC transporter superfamily
HUE56_RS08520	COG4608	Belongs to the ABC transporter superfamily
HUE56_RS08525	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HUE56_RS08535	COG2423	ornithine cyclodeaminase activity
HUE56_RS08540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUE56_RS08550	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HUE56_RS08555	COG1177	transmembrane transport
HUE56_RS08560	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUE56_RS08565	COG3842	ATPase activity
HUE56_RS08620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUE56_RS08630	COG0683	leucine binding
HUE56_RS08640	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUE56_RS08645	COG0411	ABC transporter
HUE56_RS08665	COG1116	anion transmembrane transporter activity
HUE56_RS08670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUE56_RS08675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUE56_RS08700	COG0649	NAD binding
HUE56_RS08705	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE56_RS08715	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUE56_RS08720	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE56_RS08725	COG0651	ATP synthesis coupled electron transport
HUE56_RS08740	COG2414	aldehyde ferredoxin oxidoreductase
HUE56_RS08775	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS08780	COG3246	L-lysine catabolic process to acetate
HUE56_RS08785	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUE56_RS08790	COG2204	response regulator
HUE56_RS08800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUE56_RS08810	COG2223	nitrite transmembrane transporter activity
HUE56_RS08825	COG2113	Glycine betaine
HUE56_RS08845	COG1902	pentaerythritol trinitrate reductase activity
HUE56_RS08845	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUE56_RS08850	COG0247	lactate metabolic process
HUE56_RS08850	COG2181	nitrate reductase activity
HUE56_RS08865	COG4175	Glycine betaine
HUE56_RS08870	COG4176	ABC-type proline glycine betaine transport system permease component
HUE56_RS08885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUE56_RS08900	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUE56_RS08905	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
HUE56_RS08915	COG0189	ligase activity
HUE56_RS08920	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
HUE56_RS08930	COG0702	epimerase
HUE56_RS08945	COG1229	Formylmethanofuran dehydrogenase subunit A
HUE56_RS08950	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
HUE56_RS08990	COG1891	lyase activity
HUE56_RS09020	COG4974	Belongs to the 'phage' integrase family
HUE56_RS09030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUE56_RS09040	COG1187	pseudouridine synthase activity
HUE56_RS09045	COG1960	acyl-CoA dehydrogenase activity
HUE56_RS09060	COG0318	PFAM AMP-dependent synthetase and ligase
HUE56_RS09075	COG3162	membrane
HUE56_RS09090	COG2202	Pas domain
HUE56_RS09090	COG2205	protein histidine kinase activity
HUE56_RS09115	COG0584	glycerophosphoryl diester phosphodiesterase
HUE56_RS09120	COG1509	lysine 2,3-aminomutase activity
HUE56_RS09200	COG0745	RESPONSE REGULATOR receiver
HUE56_RS09220	COG0406	alpha-ribazole phosphatase activity
HUE56_RS09315	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HUE56_RS09340	COG2264	protein methyltransferase activity
HUE56_RS09360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUE56_RS09365	COG2205	protein histidine kinase activity
HUE56_RS09370	COG0745	RESPONSE REGULATOR receiver
HUE56_RS09385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HUE56_RS09395	COG3842	ATPase activity
HUE56_RS09400	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HUE56_RS09405	COG3706	GGDEF domain
HUE56_RS09410	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUE56_RS09415	COG0268	Binds directly to 16S ribosomal RNA
HUE56_RS09420	COG1024	Enoyl-CoA hydratase
HUE56_RS09430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUE56_RS09465	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HUE56_RS09475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUE56_RS09485	COG0747	negative chemotaxis
HUE56_RS09490	COG4166	transmembrane transport
HUE56_RS09495	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUE56_RS09510	COG0039	L-malate dehydrogenase activity
HUE56_RS09525	COG0598	Magnesium transport protein CorA
HUE56_RS09530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUE56_RS09535	COG1872	DUF167
HUE56_RS09555	COG0285	dihydrofolate synthase activity
HUE56_RS09560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUE56_RS09570	COG0133	tryptophan synthase activity
HUE56_RS09575	COG2205	protein histidine kinase activity
HUE56_RS09575	COG0784	Response regulator, receiver
HUE56_RS09585	COG2204	response regulator
HUE56_RS09590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUE56_RS09605	COG2205	protein histidine kinase activity
HUE56_RS09620	COG0802	atpase or kinase
HUE56_RS09630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUE56_RS09635	COG2887	Belongs to the helicase family. UvrD subfamily
HUE56_RS09650	COG1074	ATP-dependent DNA helicase activity
HUE56_RS09655	COG3118	belongs to the thioredoxin family
HUE56_RS09685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUE56_RS09735	COG3258	Cytochrome c
HUE56_RS09775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUE56_RS09820	COG2070	2-Nitropropane dioxygenase
HUE56_RS09825	COG0527	aspartate kinase activity
HUE56_RS09830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUE56_RS09835	COG4636	protein conserved in cyanobacteria
HUE56_RS09840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUE56_RS09845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUE56_RS09850	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HUE56_RS09855	COG1137	ATPase activity
HUE56_RS09870	COG0517	IMP dehydrogenase activity
HUE56_RS09870	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUE56_RS09895	COG2223	nitrite transmembrane transporter activity
HUE56_RS09925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUE56_RS09930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUE56_RS09935	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUE56_RS09950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUE56_RS09955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUE56_RS09965	COG1573	uracil-dna glycosylase
HUE56_RS09975	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUE56_RS09985	COG4974	Belongs to the 'phage' integrase family
HUE56_RS10005	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUE56_RS10050	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUE56_RS10070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUE56_RS10080	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUE56_RS10080	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUE56_RS10090	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HUE56_RS10100	COG0642	Histidine kinase
HUE56_RS10105	COG0745	RESPONSE REGULATOR receiver
HUE56_RS10120	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HUE56_RS10190	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HUE56_RS10210	COG0443	Heat shock 70 kDa protein
HUE56_RS10215	COG0484	heat shock protein binding
HUE56_RS10225	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HUE56_RS10230	COG0667	Aldo Keto reductase
HUE56_RS10245	COG4181	ATPase activity
HUE56_RS10255	COG0670	Belongs to the BI1 family
HUE56_RS10265	COG0745	RESPONSE REGULATOR receiver
HUE56_RS10270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUE56_RS10280	COG0573	inorganic phosphate transmembrane transporter activity
HUE56_RS10285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUE56_RS10290	COG5002	protein histidine kinase activity
HUE56_RS10305	COG0281	malic enzyme
HUE56_RS10305	COG0280	phosphate acetyltransferase
HUE56_RS10310	COG2814	Major facilitator Superfamily
HUE56_RS10315	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HUE56_RS10320	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUE56_RS10325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUE56_RS10330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUE56_RS10345	COG0357	Ribosomal RNA small subunit methyltransferase G
HUE56_RS10350	COG0445	tRNA wobble uridine modification
HUE56_RS10370	COG1331	Highly conserved protein containing a thioredoxin domain
HUE56_RS10385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUE56_RS10390	COG0237	dephospho-CoA kinase activity
HUE56_RS10425	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HUE56_RS10430	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HUE56_RS10440	COG4395	Tim44
HUE56_RS10445	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HUE56_RS10450	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HUE56_RS10510	COG4235	cytochrome complex assembly
HUE56_RS10515	COG3088	subunit of a heme lyase
HUE56_RS10520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUE56_RS10525	COG1138	Cytochrome C-type biogenesis protein
HUE56_RS10530	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HUE56_RS10540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUE56_RS10560	COG1185	polyribonucleotide nucleotidyltransferase activity
HUE56_RS10565	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUE56_RS10570	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUE56_RS10595	COG0779	Required for maturation of 30S ribosomal subunits
HUE56_RS10600	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUE56_RS10605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUE56_RS10610	COG1396	sequence-specific DNA binding
HUE56_RS10615	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HUE56_RS10620	COG1253	flavin adenine dinucleotide binding
HUE56_RS10630	COG1702	phosphate starvation-inducible protein PhoH
HUE56_RS10635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUE56_RS10650	COG0302	gtp cyclohydrolase
HUE56_RS10655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUE56_RS10665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUE56_RS10670	COG0668	transmembrane transport
HUE56_RS10690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUE56_RS10705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUE56_RS10715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUE56_RS10730	COG0730	response to heat
HUE56_RS10745	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HUE56_RS10755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUE56_RS10760	COG0745	RESPONSE REGULATOR receiver
HUE56_RS10780	COG0606	chelatase, subunit chli
HUE56_RS10795	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HUE56_RS10800	COG0180	Tryptophanyl-tRNA synthetase
HUE56_RS10815	COG0792	nuclease activity
HUE56_RS10820	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUE56_RS10850	COG2985	domain, Protein
HUE56_RS10850	COG0569	domain protein
HUE56_RS10860	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUE56_RS10865	COG0386	Belongs to the glutathione peroxidase family
HUE56_RS10890	COG0739	heme binding
HUE56_RS10940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUE56_RS10945	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUE56_RS10955	COG2852	Protein conserved in bacteria
HUE56_RS10960	COG2890	protein-(glutamine-N5) methyltransferase activity
HUE56_RS10980	COG0542	response to heat
HUE56_RS10985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUE56_RS10995	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HUE56_RS11020	COG3162	membrane
HUE56_RS11040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUE56_RS11060	COG4106	trans-aconitate 2-methyltransferase activity
HUE56_RS11080	COG5001	Diguanylate cyclase
HUE56_RS11090	COG1473	amidohydrolase
HUE56_RS11095	COG3813	Protein conserved in bacteria
HUE56_RS11110	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUE56_RS11150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUE56_RS11245	COG2423	ornithine cyclodeaminase activity
HUE56_RS11255	COG0776	regulation of translation
HUE56_RS11270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUE56_RS11300	COG0783	Belongs to the Dps family
HUE56_RS11310	COG0840	transmembrane signaling receptor activity
HUE56_RS11315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUE56_RS11320	COG0137	argininosuccinate synthase activity
HUE56_RS11355	COG1272	protein, Hemolysin III
HUE56_RS11405	COG0583	DNA-binding transcription factor activity
HUE56_RS11410	COG0477	Major facilitator Superfamily
HUE56_RS11415	COG1024	Enoyl-CoA hydratase
HUE56_RS11425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUE56_RS11425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUE56_RS11435	COG0138	bifunctional purine biosynthesis protein purh
HUE56_RS11455	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HUE56_RS11460	COG0583	DNA-binding transcription factor activity
HUE56_RS11475	COG1253	flavin adenine dinucleotide binding
HUE56_RS11485	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUE56_RS11495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUE56_RS11540	COG3660	Nucleoside-diphosphate-sugar epimerase
HUE56_RS11545	COG1522	sequence-specific DNA binding
HUE56_RS11560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUE56_RS11565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUE56_RS11580	COG3005	denitrification pathway
HUE56_RS11590	COG0243	molybdopterin cofactor binding
HUE56_RS11610	COG2205	protein histidine kinase activity
HUE56_RS11620	COG2318	DinB family
HUE56_RS11625	COG1674	ftsk spoiiie
HUE56_RS11635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUE56_RS11645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUE56_RS11650	COG1238	metal cluster binding
HUE56_RS11705	COG0539	negative regulation of cytoplasmic translation
HUE56_RS11715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUE56_RS11725	COG0574	Belongs to the PEP-utilizing enzyme family
HUE56_RS11725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUE56_RS11730	COG1396	sequence-specific DNA binding
HUE56_RS11735	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HUE56_RS11745	COG3668	Plasmid stabilization system
HUE56_RS11750	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HUE56_RS11770	COG1643	Atp-dependent helicase
HUE56_RS11805	COG4191	Histidine kinase
HUE56_RS11820	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUE56_RS11835	COG0045	succinate-CoA ligase (ADP-forming) activity
HUE56_RS11840	COG0039	L-malate dehydrogenase activity
HUE56_RS11870	COG0640	Transcriptional regulator
HUE56_RS11885	COG1970	mechanosensitive ion channel activity
HUE56_RS11890	COG0653	protein targeting
HUE56_RS11895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUE56_RS11900	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUE56_RS11905	COG0494	nUDIX hydrolase
HUE56_RS11910	COG0514	ATP-dependent DNA helicase (RecQ)
HUE56_RS11920	COG0024	Methionine aminopeptidase
HUE56_RS11925	COG1489	DNA binding
HUE56_RS11930	COG1546	Belongs to the CinA family
HUE56_RS11930	COG1058	Belongs to the CinA family
HUE56_RS11960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUE56_RS11975	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HUE56_RS11980	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HUE56_RS11995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUE56_RS12005	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUE56_RS12010	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUE56_RS12030	COG0126	phosphoglycerate kinase activity
HUE56_RS12045	COG4106	trans-aconitate 2-methyltransferase activity
HUE56_RS12055	COG4191	Histidine kinase
HUE56_RS12065	COG1278	Cold shock
HUE56_RS12080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUE56_RS12095	COG0840	transmembrane signaling receptor activity
HUE56_RS12100	COG4974	Belongs to the 'phage' integrase family
HUE56_RS12110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUE56_RS12130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUE56_RS12140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUE56_RS12150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUE56_RS12160	COG0625	glutathione transferase activity
HUE56_RS12165	COG0513	Belongs to the DEAD box helicase family
HUE56_RS12170	COG2032	superoxide dismutase activity
HUE56_RS12235	COG0167	dihydroorotate dehydrogenase activity
HUE56_RS12255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUE56_RS12260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUE56_RS12275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUE56_RS12290	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HUE56_RS12320	COG3327	negative regulation of DNA-templated transcription, initiation
HUE56_RS12350	COG0625	glutathione transferase activity
HUE56_RS12375	COG1278	Cold shock
HUE56_RS12395	COG0586	Pfam SNARE associated Golgi protein
HUE56_RS12420	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUE56_RS12430	COG2205	protein histidine kinase activity
HUE56_RS12445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUE56_RS12450	COG0681	Belongs to the peptidase S26 family
HUE56_RS12470	COG2350	Protein conserved in bacteria
HUE56_RS12485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUE56_RS12500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUE56_RS12525	COG3279	Response regulator of the LytR AlgR family
HUE56_RS12540	COG0784	Response regulator, receiver
HUE56_RS12540	COG5002	protein histidine kinase activity
HUE56_RS12540	COG2205	protein histidine kinase activity
HUE56_RS12560	COG1595	DNA-templated transcription, initiation
HUE56_RS12580	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HUE56_RS12585	COG0242	peptide deformylase activity
HUE56_RS12590	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUE56_RS12595	COG0101	tRNA pseudouridine synthase activity
HUE56_RS12600	COG4191	Histidine kinase
HUE56_RS12615	COG0747	negative chemotaxis
HUE56_RS12620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUE56_RS12635	COG2193	ferroxidase activity
HUE56_RS12645	COG1192	Involved in chromosome partitioning
HUE56_RS12650	COG0009	L-threonylcarbamoyladenylate synthase
HUE56_RS12665	COG0277	FAD linked oxidase domain protein
HUE56_RS12680	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HUE56_RS12685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUE56_RS12695	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HUE56_RS12710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUE56_RS12720	COG1902	pentaerythritol trinitrate reductase activity
HUE56_RS12725	COG1278	Cold shock
HUE56_RS12775	COG0436	Aminotransferase
HUE56_RS12780	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS12795	COG1322	Protein conserved in bacteria
HUE56_RS12825	COG0071	Belongs to the small heat shock protein (HSP20) family
HUE56_RS12830	COG0579	oxidoreductase
HUE56_RS12835	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUE56_RS12855	COG1366	Belongs to the anti-sigma-factor antagonist family
HUE56_RS12865	COG2201	protein-glutamate methylesterase activity
HUE56_RS12870	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HUE56_RS12880	COG0840	transmembrane signaling receptor activity
HUE56_RS12885	COG0835	chemotaxis
HUE56_RS12890	COG2198	Histidine kinase
HUE56_RS12890	COG0643	Histidine kinase
HUE56_RS12895	COG0745	RESPONSE REGULATOR receiver
HUE56_RS12905	COG1051	belongs to the nudix hydrolase family
HUE56_RS12920	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUE56_RS12925	COG0799	negative regulation of ribosome biogenesis
HUE56_RS12930	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HUE56_RS12935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HUE56_RS12940	COG4942	peptidase
HUE56_RS12945	COG0793	Belongs to the peptidase S41A family
HUE56_RS12960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUE56_RS12970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUE56_RS12975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUE56_RS12980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUE56_RS13000	COG0071	Belongs to the small heat shock protein (HSP20) family
HUE56_RS13010	COG0254	rRNA binding
HUE56_RS13015	COG1132	(ABC) transporter
HUE56_RS13020	COG0842	Transport permease protein
HUE56_RS13035	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HUE56_RS13070	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HUE56_RS13075	COG3243	poly(R)-hydroxyalkanoic acid synthase
HUE56_RS13080	COG0183	Belongs to the thiolase family
HUE56_RS13085	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS13090	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUE56_RS13100	COG2835	tetraacyldisaccharide 4'-kinase activity
HUE56_RS13110	COG3118	belongs to the thioredoxin family
HUE56_RS13115	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
HUE56_RS13135	COG0463	Glycosyl transferase, family 2
HUE56_RS13145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUE56_RS13175	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HUE56_RS13195	COG0312	modulator of DNA gyrase
HUE56_RS13200	COG0004	ammonium transporteR
HUE56_RS13205	COG0047	phosphoribosylformylglycinamidine synthase activity
HUE56_RS13210	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUE56_RS13215	COG1234	tRNA 3'-trailer cleavage
HUE56_RS13220	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HUE56_RS13225	COG2770	Histidine kinase
HUE56_RS13225	COG3437	response regulator, receiver
HUE56_RS13245	COG2197	response regulator
HUE56_RS13255	COG0751	glycine-tRNA ligase activity
HUE56_RS13260	COG0752	glycyl-tRNA synthetase alpha subunit
HUE56_RS13275	COG0519	Catalyzes the synthesis of GMP from XMP
HUE56_RS13305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUE56_RS13315	COG3852	Histidine kinase
HUE56_RS13320	COG4191	Histidine kinase
HUE56_RS13325	COG5002	protein histidine kinase activity
HUE56_RS13335	COG2176	DNA-directed DNA polymerase activity
HUE56_RS13335	COG5002	protein histidine kinase activity
HUE56_RS13340	COG0745	RESPONSE REGULATOR receiver
HUE56_RS13350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUE56_RS13375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUE56_RS13390	COG1104	cysteine desulfurase activity
HUE56_RS13400	COG5554	nitrogen fixation
HUE56_RS13415	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUE56_RS13435	COG1309	transcriptional regulator
HUE56_RS13445	COG1131	(ABC) transporter
HUE56_RS13465	COG4191	Histidine kinase
HUE56_RS13465	COG0784	Response regulator, receiver
HUE56_RS13495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUE56_RS13520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUE56_RS13525	COG1346	cytolysis
HUE56_RS13530	COG1380	Effector of murein hydrolase LrgA
HUE56_RS13550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUE56_RS13555	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUE56_RS13560	COG0793	Belongs to the peptidase S41A family
HUE56_RS13565	COG0557	exoribonuclease II activity
HUE56_RS13575	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUE56_RS13590	COG1086	Polysaccharide biosynthesis protein
HUE56_RS13610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUE56_RS13635	COG0717	Belongs to the dCTP deaminase family
HUE56_RS13640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUE56_RS13655	COG0693	protein deglycase activity
HUE56_RS13660	COG2197	response regulator
HUE56_RS13665	COG2197	response regulator
HUE56_RS13670	COG0829	nickel cation binding
HUE56_RS13675	COG0831	urea catabolic process
HUE56_RS13680	COG0832	Belongs to the urease beta subunit family
HUE56_RS13685	COG0804	urea catabolic process
HUE56_RS13690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUE56_RS13695	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HUE56_RS13700	COG0830	nickel cation binding
HUE56_RS13705	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUE56_RS13720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUE56_RS13735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUE56_RS13740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUE56_RS13745	COG0028	Belongs to the TPP enzyme family
HUE56_RS13765	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUE56_RS13770	COG0640	Transcriptional regulator
HUE56_RS13780	COG0768	penicillin binding
HUE56_RS13800	COG2862	Uncharacterized protein family, UPF0114
HUE56_RS13810	COG0140	phosphoribosyl-ATP diphosphatase activity
HUE56_RS13815	COG0500	methyltransferase
HUE56_RS13840	COG0583	DNA-binding transcription factor activity
HUE56_RS13905	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE56_RS13910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE56_RS13915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE56_RS13920	COG0649	NAD binding
HUE56_RS13925	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HUE56_RS13930	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUE56_RS13935	COG1034	ATP synthesis coupled electron transport
HUE56_RS13940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUE56_RS13955	COG0713	ATP synthesis coupled electron transport
HUE56_RS13970	COG1007	ATP synthesis coupled electron transport
HUE56_RS13990	COG0346	lactoylglutathione lyase activity
HUE56_RS14000	COG0519	Catalyzes the synthesis of GMP from XMP
HUE56_RS14015	COG0442	prolyl-tRNA aminoacylation
HUE56_RS14025	COG1136	(ABC) transporter
HUE56_RS14035	COG1335	isochorismatase
HUE56_RS14040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUE56_RS14045	COG0564	pseudouridine synthase activity
HUE56_RS14050	COG0546	phosphoglycolate phosphatase activity
HUE56_RS14065	COG0354	folic acid binding
HUE56_RS14145	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HUE56_RS14160	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUE56_RS14165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUE56_RS14175	COG0248	Ppx GppA phosphatase
HUE56_RS14195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUE56_RS14210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUE56_RS14215	COG0849	cell division
HUE56_RS14220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUE56_RS14225	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUE56_RS14230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUE56_RS14235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUE56_RS14245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUE56_RS14255	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUE56_RS14260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUE56_RS14270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUE56_RS14290	COG2001	Belongs to the MraZ family
HUE56_RS14300	COG3023	N-Acetylmuramoyl-L-alanine amidase
HUE56_RS14335	COG3284	Transcriptional regulator
HUE56_RS14350	COG0482	sulfurtransferase activity
HUE56_RS14360	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HUE56_RS14375	COG1045	serine acetyltransferase
HUE56_RS14380	COG2945	thiolester hydrolase activity
HUE56_RS14405	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUE56_RS14410	COG0193	aminoacyl-tRNA hydrolase activity
HUE56_RS14420	COG1283	sodium-dependent phosphate transmembrane transporter activity
HUE56_RS14425	COG5001	Diguanylate cyclase
HUE56_RS14425	COG3300	MHYT domain
HUE56_RS14465	COG0418	dihydroorotase activity
HUE56_RS14470	COG1570	exodeoxyribonuclease VII activity
HUE56_RS14490	COG0590	tRNA wobble adenosine to inosine editing
HUE56_RS14495	COG1187	pseudouridine synthase activity
HUE56_RS14500	COG0742	ribosomal rna small subunit methyltransferase
HUE56_RS14515	COG0366	Alpha amylase catalytic
HUE56_RS14525	COG2910	NAD(P)H-binding
HUE56_RS14530	COG2337	Toxic component of a toxin-antitoxin (TA) module
HUE56_RS14540	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUE56_RS14575	COG2197	response regulator
HUE56_RS14580	COG2197	response regulator
HUE56_RS14585	COG0210	DNA helicase
HUE56_RS14595	COG2264	protein methyltransferase activity
HUE56_RS14605	COG0006	proline dipeptidase activity
HUE56_RS14625	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUE56_RS14630	COG0497	DNA recombination
HUE56_RS14635	COG0583	DNA-binding transcription factor activity
HUE56_RS14640	COG0494	nUDIX hydrolase
HUE56_RS14645	COG4251	negative regulation of phosphorylation
HUE56_RS14650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUE56_RS14650	COG0357	Ribosomal RNA small subunit methyltransferase G
HUE56_RS14665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUE56_RS14665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUE56_RS14670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUE56_RS14680	COG2205	protein histidine kinase activity
HUE56_RS14695	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HUE56_RS14710	COG0523	cobalamin synthesis protein
HUE56_RS14715	COG0735	belongs to the Fur family
HUE56_RS14720	COG0415	Belongs to the DNA photolyase family
HUE56_RS14735	COG1201	RNA secondary structure unwinding
HUE56_RS14745	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUE56_RS14750	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HUE56_RS14755	COG0242	peptide deformylase activity
HUE56_RS14780	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HUE56_RS14790	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUE56_RS14800	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUE56_RS14805	COG0154	amidase activity
HUE56_RS14830	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUE56_RS14835	COG1116	anion transmembrane transporter activity
HUE56_RS14875	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUE56_RS14875	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUE56_RS14930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUE56_RS14930	COG0551	DNA topoisomerase type I activity
HUE56_RS14940	COG0251	oxidation-reduction process
HUE56_RS14945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUE56_RS14960	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUE56_RS14975	COG0203	ribosomal protein L17
HUE56_RS14980	COG1238	metal cluster binding
HUE56_RS14995	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUE56_RS15015	COG3447	MASE1 domain protein
HUE56_RS15015	COG5001	Diguanylate cyclase
HUE56_RS15015	COG5002	protein histidine kinase activity
HUE56_RS15035	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUE56_RS15075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUE56_RS15185	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUE56_RS15190	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUE56_RS15200	COG2873	o-acetylhomoserine
HUE56_RS15205	COG1832	CoA-binding protein
HUE56_RS15210	COG1024	Enoyl-CoA hydratase
HUE56_RS15215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUE56_RS15220	COG0758	DNA mediated transformation
HUE56_RS15230	COG1024	Enoyl-CoA hydratase
HUE56_RS15240	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HUE56_RS15250	COG1309	transcriptional regulator
HUE56_RS15295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUE56_RS15295	COG4651	solute:proton antiporter activity
HUE56_RS15325	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HUE56_RS15335	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HUE56_RS15345	COG4786	Flagellar basal body rod
HUE56_RS15350	COG4786	Flagellar basal body rod
HUE56_RS15375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUE56_RS15380	COG1381	Involved in DNA repair and RecF pathway recombination
HUE56_RS15410	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HUE56_RS15415	COG0321	lipoyl(octanoyl) transferase activity
HUE56_RS15415	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUE56_RS15420	COG0084	hydrolase, TatD family'
HUE56_RS15430	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUE56_RS15435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUE56_RS15440	COG1686	Belongs to the peptidase S11 family
HUE56_RS15465	COG0488	(ABC) transporter
HUE56_RS15470	COG1012	belongs to the aldehyde dehydrogenase family
HUE56_RS15475	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HUE56_RS15485	COG0105	UTP biosynthetic process
HUE56_RS15505	COG0745	RESPONSE REGULATOR receiver
HUE56_RS15525	COG2815	serine threonine protein kinase
HUE56_RS15525	COG0515	serine threonine protein kinase
HUE56_RS15550	COG0500	methyltransferase
HUE56_RS15620	COG3501	Rhs element vgr protein
HUE56_RS15670	COG2208	phosphoserine phosphatase activity
HUE56_RS15670	COG2770	Histidine kinase
HUE56_RS15675	COG1366	Belongs to the anti-sigma-factor antagonist family
HUE56_RS15695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUE56_RS15700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUE56_RS15710	COG4191	Histidine kinase
HUE56_RS15725	COG4565	transcriptional regulatory protein
HUE56_RS15735	COG2951	lytic endotransglycosylase activity
HUE56_RS15760	COG0114	fumarate hydratase activity
HUE56_RS15780	COG5001	Diguanylate cyclase
HUE56_RS15780	COG5002	protein histidine kinase activity
HUE56_RS15795	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUE56_RS15800	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUE56_RS15815	COG0205	6-phosphofructokinase activity
HUE56_RS15840	COG0288	reversible hydration of carbon dioxide
HUE56_RS15845	COG0163	prenyltransferase activity
HUE56_RS15855	COG3321	synthase
HUE56_RS15855	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS15855	COG0604	alcohol dehydrogenase
HUE56_RS15910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUE56_RS15915	COG0840	transmembrane signaling receptor activity
HUE56_RS15925	COG2197	response regulator
HUE56_RS15940	COG1160	GTP binding
HUE56_RS15945	COG2900	Belongs to the SlyX family
HUE56_RS15950	COG1914	H( )-stimulated, divalent metal cation uptake system
HUE56_RS15985	COG0519	Catalyzes the synthesis of GMP from XMP
HUE56_RS15985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUE56_RS15990	COG1247	-acetyltransferase
HUE56_RS16000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUE56_RS16015	COG1758	RNA polymerase activity
HUE56_RS16025	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HUE56_RS16035	COG0681	Belongs to the peptidase S26 family
HUE56_RS16040	COG0571	ribonuclease III activity
HUE56_RS16045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUE56_RS16060	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HUE56_RS16070	COG1752	Esterase of the alpha-beta hydrolase superfamily
HUE56_RS16095	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HUE56_RS16105	COG1338	Plays a role in the flagellum-specific transport system
HUE56_RS16120	COG2257	FlhB HrpN YscU SpaS Family
HUE56_RS16125	COG1815	bacterial-type flagellum-dependent cell motility
HUE56_RS16130	COG1558	bacterial-type flagellum-dependent cell motility
HUE56_RS16135	COG1677	Flagellar hook-basal body complex protein FliE
HUE56_RS16140	COG1987	bacterial-type flagellum assembly
HUE56_RS16150	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUE56_RS16190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUE56_RS16200	COG2076	Multidrug Resistance protein
HUE56_RS16220	COG0312	modulator of DNA gyrase
HUE56_RS16230	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUE56_RS16235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUE56_RS16240	COG0109	protoheme IX farnesyltransferase activity
HUE56_RS16250	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HUE56_RS16255	COG1845	cytochrome c oxidase, subunit III
HUE56_RS16265	COG3346	SURF1 family
HUE56_RS16275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUE56_RS16285	COG3237	CsbD-like
HUE56_RS16300	COG1742	UPF0060 membrane protein
HUE56_RS16310	COG5001	Diguanylate cyclase
HUE56_RS16315	COG1840	ABC-type Fe3 transport system, periplasmic component
HUE56_RS16320	COG3842	ATPase activity
HUE56_RS16325	COG1132	(ABC) transporter
HUE56_RS16330	COG1752	Esterase of the alpha-beta hydrolase superfamily
HUE56_RS16350	COG1178	ABC-type Fe3 transport system permease component
HUE56_RS16370	COG2226	methyltransferase
HUE56_RS16385	COG0741	lytic transglycosylase activity
HUE56_RS16385	COG1196	nuclear chromosome segregation
HUE56_RS16385	COG0739	heme binding
HUE56_RS16395	COG5487	UPF0391 membrane protein
HUE56_RS16405	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUE56_RS16410	COG1765	OsmC-like protein
HUE56_RS16430	COG0728	peptidoglycan biosynthetic process
HUE56_RS16435	COG2205	protein histidine kinase activity
HUE56_RS16450	COG2086	electron transfer activity
HUE56_RS16460	COG0789	Transcriptional regulator
HUE56_RS16465	COG0318	PFAM AMP-dependent synthetase and ligase
HUE56_RS16485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUE56_RS16490	COG1360	Flagellar Motor Protein
HUE56_RS16495	COG2308	Evidence 4 Homologs of previously reported genes of
HUE56_RS16540	COG0626	cystathionine gamma-synthase activity
HUE56_RS16545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE56_RS16550	COG4597	amino acid ABC transporter
HUE56_RS16555	COG0765	amino acid transport
HUE56_RS16560	COG1126	abc transporter atp-binding protein
HUE56_RS16565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUE56_RS16575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUE56_RS16595	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUE56_RS16600	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUE56_RS16625	COG2199	diguanylate cyclase activity
HUE56_RS16625	COG2203	Gaf domain
HUE56_RS16635	COG0556	nucleotide-excision repair
HUE56_RS16640	COG0741	lytic transglycosylase activity
HUE56_RS16675	COG4957	zinc ion binding
HUE56_RS16680	COG0776	regulation of translation
HUE56_RS16695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUE56_RS16705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUE56_RS16710	COG0540	Belongs to the ATCase OTCase family
HUE56_RS16715	COG0583	DNA-binding transcription factor activity
HUE56_RS16740	COG0672	)-iron permease
HUE56_RS16755	COG4120	Belongs to the binding-protein-dependent transport system permease family
HUE56_RS16785	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS16795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUE56_RS16800	COG1763	Mo-molybdopterin cofactor biosynthetic process
HUE56_RS16810	COG0546	phosphoglycolate phosphatase activity
HUE56_RS16820	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HUE56_RS16825	COG0314	molybdopterin synthase activity
HUE56_RS16830	COG1678	Uncharacterized ACR, COG1678
HUE56_RS16835	COG4232	protein-disulfide reductase activity
HUE56_RS16840	COG2824	Alkylphosphonate utilization operon protein PhnA
HUE56_RS16845	COG0678	peroxiredoxin activity
HUE56_RS16855	COG0328	RNA-DNA hybrid ribonuclease activity
HUE56_RS16860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HUE56_RS16865	COG2833	Protein of unknown function (DUF455)
HUE56_RS16870	COG1218	3'(2'),5'-bisphosphate nucleotidase
HUE56_RS16890	COG2200	EAL domain
HUE56_RS16890	COG3287	FIST C domain
HUE56_RS16890	COG2199	diguanylate cyclase activity
HUE56_RS16900	COG2135	peptidase activity
HUE56_RS16915	COG2261	transglycosylase associated protein
HUE56_RS16925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUE56_RS16930	COG0725	ABC transporter, periplasmic molybdate-binding protein
HUE56_RS16935	COG4149	molybdate abc transporter
HUE56_RS16955	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUE56_RS16960	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUE56_RS16960	COG0022	dehydrogenase e1 component
HUE56_RS16965	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUE56_RS16975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUE56_RS16985	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUE56_RS16990	COG2867	negative regulation of translational initiation
HUE56_RS16995	COG1942	4-Oxalocrotonate Tautomerase
HUE56_RS17035	COG2204	response regulator
HUE56_RS17045	COG1923	regulation of RNA biosynthetic process
HUE56_RS17050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUE56_RS17065	COG0483	inositol monophosphate 1-phosphatase activity
HUE56_RS17075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUE56_RS17080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUE56_RS17085	COG1116	anion transmembrane transporter activity
HUE56_RS17090	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUE56_RS17120	COG0629	single-stranded DNA binding
HUE56_RS17125	COG0583	DNA-binding transcription factor activity
HUE56_RS17130	COG2814	Major facilitator Superfamily
HUE56_RS17135	COG2226	methyltransferase
HUE56_RS17165	COG0714	Associated with various cellular activities
HUE56_RS17180	COG0617	tRNA 3'-terminal CCA addition
HUE56_RS17195	COG0248	Ppx GppA phosphatase
HUE56_RS17200	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUE56_RS17205	COG2062	phosphohistidine phosphatase, SixA
HUE56_RS17215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUE56_RS17245	COG1562	ergosterol biosynthetic process
HUE56_RS17250	COG1562	ergosterol biosynthetic process
HUE56_RS17255	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HUE56_RS17260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUE56_RS17275	COG3737	Protein of unknown function (DUF498/DUF598)
HUE56_RS17285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUE56_RS17290	COG1862	Preprotein translocase
HUE56_RS17305	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUE56_RS17315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUE56_RS17320	COG2814	Major facilitator Superfamily
HUE56_RS17325	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HUE56_RS17355	COG3784	Protein of unknown function (DUF1318)
HUE56_RS17385	COG0583	DNA-binding transcription factor activity
HUE56_RS17395	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS17415	COG2010	Cytochrome c
HUE56_RS17420	COG2307	Protein conserved in bacteria
HUE56_RS17420	COG2308	Evidence 4 Homologs of previously reported genes of
HUE56_RS17425	COG1305	Transglutaminase-like
HUE56_RS17430	COG0745	RESPONSE REGULATOR receiver
HUE56_RS17440	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HUE56_RS17445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUE56_RS17450	COG0058	SHG alpha-glucan phosphorylase activity
HUE56_RS17455	COG0456	acetyltransferase
HUE56_RS17465	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS17480	COG2264	protein methyltransferase activity
HUE56_RS17490	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HUE56_RS17505	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUE56_RS17520	COG1846	Transcriptional regulator
HUE56_RS17525	COG1024	Enoyl-CoA hydratase
HUE56_RS17530	COG1597	lipid kinase activity
HUE56_RS17540	COG0113	porphobilinogen synthase activity
HUE56_RS17545	COG1881	PFAM PEBP family protein
HUE56_RS17560	COG0667	Aldo Keto reductase
HUE56_RS17565	COG2813	Specifically methylates the guanine in position
HUE56_RS17570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUE56_RS17575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUE56_RS17580	COG0741	lytic transglycosylase activity
HUE56_RS17595	COG0534	Mate efflux family protein
HUE56_RS17600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUE56_RS17605	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUE56_RS17640	COG1136	(ABC) transporter
HUE56_RS17640	COG0577	efflux transmembrane transporter activity
HUE56_RS17645	COG1136	(ABC) transporter
HUE56_RS17650	COG1566	PFAM secretion protein HlyD family protein
HUE56_RS17660	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HUE56_RS17685	COG0149	triose-phosphate isomerase activity
HUE56_RS17695	COG1846	Transcriptional regulator
HUE56_RS17705	COG0745	RESPONSE REGULATOR receiver
HUE56_RS17715	COG2197	response regulator
HUE56_RS17725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUE56_RS17730	COG0330	HflC and HflK could
HUE56_RS17735	COG0330	HflC and HflK could
HUE56_RS17740	COG0489	protein tyrosine kinase activity
HUE56_RS17745	COG0443	Heat shock 70 kDa protein
HUE56_RS17750	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS17775	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HUE56_RS17780	COG0784	Response regulator, receiver
HUE56_RS17780	COG5002	protein histidine kinase activity
HUE56_RS17780	COG2205	protein histidine kinase activity
HUE56_RS17790	COG2208	phosphoserine phosphatase activity
HUE56_RS17795	COG1366	Belongs to the anti-sigma-factor antagonist family
HUE56_RS17830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUE56_RS17835	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HUE56_RS17910	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUE56_RS17920	COG1396	sequence-specific DNA binding
HUE56_RS17955	COG0124	histidyl-tRNA synthetase
HUE56_RS17960	COG1846	Transcriptional regulator
HUE56_RS17965	COG0300	oxidoreductase activity
HUE56_RS17975	COG0628	permease
HUE56_RS17980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUE56_RS17990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUE56_RS17995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HUE56_RS18005	COG0525	valine-tRNA ligase activity
HUE56_RS18015	COG1538	Outer membrane efflux protein
HUE56_RS18025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUE56_RS18055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUE56_RS18060	COG0494	nUDIX hydrolase
HUE56_RS18070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUE56_RS18075	COG2897	thiosulfate sulfurtransferase activity
HUE56_RS18080	COG0454	-acetyltransferase
HUE56_RS18080	COG0456	acetyltransferase
HUE56_RS18090	COG1492	cobalamin metabolic process
HUE56_RS18155	COG0315	cyclic pyranopterin monophosphate synthase activity
HUE56_RS18160	COG0303	'Molybdopterin
HUE56_RS18165	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUE56_RS18170	COG2333	competence protein COMEC
HUE56_RS18170	COG0658	competence protein
HUE56_RS18175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUE56_RS18190	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HUE56_RS18200	COG4977	sequence-specific DNA binding
HUE56_RS18210	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUE56_RS18215	COG3494	Protein of unknown function (DUF1009)
HUE56_RS18240	COG0750	zinc metalloprotease
HUE56_RS18245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUE56_RS18255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUE56_RS18260	COG0233	cytoplasmic translational termination
HUE56_RS18265	COG0528	UMP kinase activity
HUE56_RS18270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUE56_RS18275	COG0052	Belongs to the universal ribosomal protein uS2 family
HUE56_RS18280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUE56_RS18285	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HUE56_RS18300	COG1561	YicC-like family, N-terminal region
HUE56_RS18335	COG0513	Belongs to the DEAD box helicase family
HUE56_RS18370	COG0187	DNA topoisomerase II activity
HUE56_RS18375	COG1607	acyl-coa hydrolase
HUE56_RS18385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUE56_RS18390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUE56_RS18420	COG4191	Histidine kinase
HUE56_RS18420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE56_RS18435	COG3437	response regulator, receiver
HUE56_RS18435	COG0784	Response regulator, receiver
HUE56_RS18445	COG0140	phosphoribosyl-ATP diphosphatase activity
HUE56_RS18475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUE56_RS18490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUE56_RS18495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUE56_RS18510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUE56_RS18520	COG0360	Binds together with S18 to 16S ribosomal RNA
HUE56_RS18525	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUE56_RS18535	COG0359	binds to the 23S rRNA
HUE56_RS18540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUE56_RS18545	COG0538	isocitrate dehydrogenase activity
HUE56_RS18555	COG0330	HflC and HflK could
HUE56_RS18580	COG0473	3-isopropylmalate dehydrogenase activity
HUE56_RS18620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUE56_RS18650	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUE56_RS18655	COG4221	oxidoreductase activity
HUE56_RS18660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HUE56_RS18675	COG0024	Methionine aminopeptidase
HUE56_RS18680	COG0494	nUDIX hydrolase
HUE56_RS18690	COG2132	Multicopper oxidase
HUE56_RS18705	COG4953	penicillin-binding protein 1C
HUE56_RS18710	COG2373	Large extracellular alpha-helical protein
HUE56_RS18725	COG0583	DNA-binding transcription factor activity
HUE56_RS18730	COG0303	'Molybdopterin
HUE56_RS18735	COG1324	tolerance protein
HUE56_RS18755	COG1494	fructose-1,6-bisphosphatase
HUE56_RS18765	COG0436	Aminotransferase
HUE56_RS18770	COG0840	transmembrane signaling receptor activity
HUE56_RS18770	COG3290	protein histidine kinase activity
HUE56_RS18775	COG0745	RESPONSE REGULATOR receiver
HUE56_RS18785	COG0616	signal peptide processing
HUE56_RS18795	COG0628	permease
HUE56_RS18800	COG2205	protein histidine kinase activity
HUE56_RS18810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUE56_RS18815	COG0432	Pfam Uncharacterised protein family UPF0047
HUE56_RS18835	COG0745	RESPONSE REGULATOR receiver
HUE56_RS18840	COG2205	protein histidine kinase activity
HUE56_RS18840	COG3437	response regulator, receiver
HUE56_RS18840	COG3850	Histidine kinase
HUE56_RS18840	COG4999	Histidine kinase
HUE56_RS18850	COG0784	Response regulator, receiver
HUE56_RS18855	COG4251	negative regulation of phosphorylation
HUE56_RS18860	COG4251	negative regulation of phosphorylation
HUE56_RS18865	COG0840	transmembrane signaling receptor activity
HUE56_RS18870	COG0439	Biotin carboxylase
HUE56_RS18875	COG0511	ligase activity, forming carbon-carbon bonds
HUE56_RS18910	COG3108	Peptidase M15
HUE56_RS18915	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUE56_RS18915	COG3409	Peptidoglycan-binding domain 1 protein
HUE56_RS18920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUE56_RS18945	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUE56_RS18980	COG1136	(ABC) transporter
HUE56_RS18985	COG1136	(ABC) transporter
HUE56_RS18985	COG0577	efflux transmembrane transporter activity
HUE56_RS19000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUE56_RS19015	COG1610	YqeY-like protein
HUE56_RS19030	COG1403	HNH endonuclease
HUE56_RS19040	COG2890	protein-(glutamine-N5) methyltransferase activity
HUE56_RS19045	COG1393	Belongs to the ArsC family
HUE56_RS19050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUE56_RS19065	COG1846	Transcriptional regulator
HUE56_RS19070	COG1764	response to oxidative stress
HUE56_RS19095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUE56_RS19100	COG0416	fatty acid biosynthetic process
HUE56_RS19105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUE56_RS19125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUE56_RS19125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUE56_RS19135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUE56_RS19135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUE56_RS19145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUE56_RS19160	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HUE56_RS19165	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUE56_RS19170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUE56_RS19175	COG0698	ribose 5-phosphate isomerase
HUE56_RS19180	COG4957	zinc ion binding
HUE56_RS19195	COG3685	Protein conserved in bacteria
HUE56_RS19210	COG2153	protein acetylation
HUE56_RS19240	COG0259	pyridoxamine-phosphate oxidase activity
HUE56_RS19245	COG4520	surface antigen
HUE56_RS19255	COG1295	ribonuclease BN
HUE56_RS19260	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUE56_RS19280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUE56_RS19285	COG0037	tRNA processing
HUE56_RS19295	COG2885	chlorophyll binding
HUE56_RS19310	COG0848	biopolymer transport protein
HUE56_RS19320	COG0824	Thioesterase
HUE56_RS19325	COG2255	four-way junction helicase activity
HUE56_RS19340	COG0217	transcriptional regulatory protein
HUE56_RS19350	COG1692	metallophosphoesterase
HUE56_RS19355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUE56_RS19405	COG1830	Aldolase
HUE56_RS19410	COG0352	thiamine-phosphate diphosphorylase activity
HUE56_RS19415	COG0730	response to heat
HUE56_RS19430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUE56_RS19435	COG0483	inositol monophosphate 1-phosphatase activity
HUE56_RS19455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUE56_RS19460	COG0612	Peptidase, M16
HUE56_RS19470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUE56_RS19480	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HUE56_RS19480	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUE56_RS19485	COG0243	molybdopterin cofactor binding
HUE56_RS19510	COG4566	intracellular signal transduction
HUE56_RS19515	COG2202	Pas domain
HUE56_RS19515	COG2205	protein histidine kinase activity
HUE56_RS19525	COG3108	Peptidase M15
HUE56_RS19540	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUE56_RS19550	COG1648	precorrin-2 dehydrogenase activity
HUE56_RS19550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUE56_RS19555	COG0175	sulfate reduction
HUE56_RS19560	COG0175	sulfate reduction
HUE56_RS19570	COG2814	Major facilitator Superfamily
HUE56_RS19575	COG0583	DNA-binding transcription factor activity
HUE56_RS19580	COG0488	(ABC) transporter
HUE56_RS19585	COG2070	2-Nitropropane dioxygenase
HUE56_RS19590	COG3706	GGDEF domain
HUE56_RS19615	COG0646	methionine synthase
HUE56_RS19615	COG1410	methionine synthase
HUE56_RS19630	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HUE56_RS19640	COG2853	Lipoprotein
HUE56_RS19670	COG0488	(ABC) transporter
HUE56_RS19675	COG1671	Belongs to the UPF0178 family
HUE56_RS19690	COG0277	FAD linked oxidase domain protein
HUE56_RS19695	COG3199	ATP-NAD kinase
HUE56_RS19700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUE56_RS19705	COG0022	dehydrogenase e1 component
HUE56_RS19710	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUE56_RS19710	COG0596	Alpha beta hydrolase
HUE56_RS19720	COG1063	alcohol dehydrogenase
HUE56_RS19725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUE56_RS19735	COG0582	viral genome integration into host DNA
HUE56_RS19770	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HUE56_RS19780	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HUE56_RS19785	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HUE56_RS19790	COG2205	protein histidine kinase activity
HUE56_RS19795	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HUE56_RS19800	COG2301	Belongs to the HpcH HpaI aldolase family
HUE56_RS19845	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUE56_RS19850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUE56_RS19855	COG0552	protein localization to endoplasmic reticulum
HUE56_RS19860	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUE56_RS19870	COG0121	glutamine amidotransferase
HUE56_RS19920	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HUE56_RS19925	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HUE56_RS19940	COG5420	small protein containing a coiled-coil domain
HUE56_RS19945	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
HUE56_RS19955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUE56_RS19980	COG1573	uracil-dna glycosylase
HUE56_RS19985	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUE56_RS19990	COG4948	Mandelate Racemase Muconate Lactonizing
HUE56_RS20015	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HUE56_RS20020	COG2894	cell division
HUE56_RS20025	COG0850	regulation of cytokinetic process
HUE56_RS20030	COG1702	phosphate starvation-inducible protein PhoH
HUE56_RS20040	COG1999	signal sequence binding
HUE56_RS20050	COG0356	it plays a direct role in the translocation of protons across the membrane
HUE56_RS20055	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUE56_RS20060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUE56_RS20070	COG3384	dioxygenase
HUE56_RS20075	COG0784	Response regulator, receiver
HUE56_RS20075	COG5002	protein histidine kinase activity
HUE56_RS20080	COG0235	Class ii aldolase
HUE56_RS20095	COG0437	4 iron, 4 sulfur cluster binding
HUE56_RS20100	COG3383	formate dehydrogenase (NAD+) activity
HUE56_RS20125	COG0746	molybdenum cofactor guanylyltransferase activity
HUE56_RS20130	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUE56_RS20150	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUE56_RS20155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUE56_RS20170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUE56_RS20185	COG2703	oxygen carrier activity
HUE56_RS20190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUE56_RS20220	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUE56_RS20235	COG0612	Peptidase, M16
HUE56_RS20240	COG0612	Peptidase, M16
HUE56_RS20250	COG0166	Belongs to the GPI family
HUE56_RS20270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUE56_RS20280	COG2205	protein histidine kinase activity
HUE56_RS20285	COG5002	protein histidine kinase activity
HUE56_RS20290	COG2205	protein histidine kinase activity
HUE56_RS20290	COG2202	Pas domain
HUE56_RS20305	COG1686	Belongs to the peptidase S11 family
HUE56_RS20330	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUE56_RS20355	COG1366	Belongs to the anti-sigma-factor antagonist family
HUE56_RS20360	COG3852	Histidine kinase
HUE56_RS20405	COG0501	Belongs to the peptidase M48B family
HUE56_RS20410	COG5508	conserved small protein
HUE56_RS20415	COG3842	ATPase activity
HUE56_RS20420	COG0395	ABC-type sugar transport system, permease component
HUE56_RS20435	COG2205	protein histidine kinase activity
HUE56_RS20450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUE56_RS20460	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HUE56_RS20465	COG2962	Rard protein
HUE56_RS20475	COG1902	pentaerythritol trinitrate reductase activity
HUE56_RS20530	COG0644	oxidoreductase
HUE56_RS20535	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HUE56_RS20545	COG2205	protein histidine kinase activity
HUE56_RS20545	COG0784	Response regulator, receiver
HUE56_RS20545	COG5002	protein histidine kinase activity
HUE56_RS20555	COG1280	lysine exporter protein (LysE YggA)
HUE56_RS20565	COG1663	tetraacyldisaccharide 4'-kinase activity
HUE56_RS20570	COG1519	Transferase
HUE56_RS20570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUE56_RS20575	COG1280	lysine exporter protein (LysE YggA)
HUE56_RS20580	COG0438	transferase activity, transferring glycosyl groups
HUE56_RS20590	COG1597	lipid kinase activity
HUE56_RS20600	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUE56_RS20605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUE56_RS20635	COG0628	permease
HUE56_RS20650	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUE56_RS20655	COG2030	dehydratase
HUE56_RS20660	COG0196	riboflavin kinase activity
HUE56_RS20670	COG2814	Major facilitator Superfamily
HUE56_RS20675	COG1285	pathogenesis
HUE56_RS20705	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HUE56_RS20715	COG2267	carboxylic ester hydrolase activity
HUE56_RS20720	COG2873	o-acetylhomoserine
HUE56_RS20725	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUE56_RS20740	COG0697	spore germination
HUE56_RS20750	COG0563	adenylate kinase activity
HUE56_RS20760	COG0200	Binds to the 23S rRNA
HUE56_RS20765	COG1841	ribosomal large subunit assembly
HUE56_RS20770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUE56_RS20780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUE56_RS20785	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUE56_RS20790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUE56_RS20800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUE56_RS20810	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUE56_RS20815	COG0255	Belongs to the universal ribosomal protein uL29 family
HUE56_RS20820	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUE56_RS20825	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUE56_RS20830	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUE56_RS20835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUE56_RS20840	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUE56_RS20845	COG0089	rRNA binding
HUE56_RS20850	COG0088	Forms part of the polypeptide exit tunnel
HUE56_RS20860	COG0051	transcription antitermination factor activity, RNA binding
HUE56_RS20865	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUE56_RS20875	COG0049	tRNA binding
HUE56_RS20885	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUE56_RS20890	COG0085	RNA polymerase activity
HUE56_RS20895	COG0222	ribosome binding
HUE56_RS20900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUE56_RS20905	COG0081	regulation of translation
HUE56_RS20910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUE56_RS20930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUE56_RS21020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUE56_RS21025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUE56_RS21030	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HUE56_RS21065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUE56_RS21065	COG1877	trehalose-phosphatase activity
HUE56_RS21095	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HUE56_RS21100	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUE56_RS21105	COG1530	ribonuclease E activity
HUE56_RS21115	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HUE56_RS21130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUE56_RS21140	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HUE56_RS21145	COG0706	membrane insertase activity
HUE56_RS21150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUE56_RS21160	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUE56_RS21165	COG0335	large ribosomal subunit rRNA binding
HUE56_RS21170	COG0336	Belongs to the RNA methyltransferase TrmD family
HUE56_RS21175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUE56_RS21180	COG0228	four-way junction DNA binding
HUE56_RS21185	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUE56_RS21220	COG2171	N-acyltransferase activity
HUE56_RS21225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUE56_RS21245	COG1960	acyl-CoA dehydrogenase activity
HUE56_RS21255	COG1454	alcohol dehydrogenase
HUE56_RS21280	COG0247	lactate metabolic process
HUE56_RS21285	COG0277	FAD linked oxidase domain protein
HUE56_RS21290	COG0277	FAD linked oxidase domain protein
HUE56_RS21295	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUE56_RS21305	COG0745	RESPONSE REGULATOR receiver
HUE56_RS21310	COG2205	protein histidine kinase activity
HUE56_RS21330	COG3108	Peptidase M15
HUE56_RS21335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUE56_RS21420	COG2022	thiamine diphosphate biosynthetic process
HUE56_RS21430	COG2022	thiamine diphosphate biosynthetic process
HUE56_RS21430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUE56_RS21435	COG0840	transmembrane signaling receptor activity
HUE56_RS21435	COG3290	protein histidine kinase activity
HUE56_RS21440	COG2239	Acts as a magnesium transporter
HUE56_RS21455	COG0671	phosphoesterase, PA-phosphatase related
HUE56_RS21555	COG1254	Belongs to the acylphosphatase family
HUE56_RS21560	COG0318	PFAM AMP-dependent synthetase and ligase
HUE56_RS21580	COG2719	SpoVR family
HUE56_RS21585	COG2718	Belongs to the UPF0229 family
HUE56_RS21590	COG2766	serine protein kinase
HUE56_RS21595	COG0745	RESPONSE REGULATOR receiver
HUE56_RS21605	COG3474	cytochrome
HUE56_RS21615	COG0077	Prephenate dehydratase
HUE56_RS21645	COG4166	transmembrane transport
HUE56_RS21650	COG4166	transmembrane transport
HUE56_RS21655	COG4174	ABC transporter (Permease)
HUE56_RS21660	COG4239	(ABC) transporter, permease
HUE56_RS21665	COG4172	Belongs to the ABC transporter superfamily
HUE56_RS21670	COG1703	isobutyryl-CoA mutase activity
HUE56_RS21680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUE56_RS21685	COG2137	regulation of response to DNA damage stimulus
HUE56_RS21690	COG0842	Transport permease protein
HUE56_RS21695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUE56_RS21700	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUE56_RS21710	COG3609	addiction module antidote protein, CC2985 family
HUE56_RS21730	COG3158	transport of potassium into the cell
HUE56_RS21735	COG3437	response regulator, receiver
HUE56_RS21735	COG0784	Response regulator, receiver
HUE56_RS21750	COG0587	DNA-directed DNA polymerase activity
HUE56_RS21775	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUE56_RS21785	COG0181	hydroxymethylbilane synthase activity
HUE56_RS21815	COG1442	glycosyl transferase family 8
HUE56_RS21815	COG1216	Glycosyl transferase, family 2
HUE56_RS21835	COG1842	Phage shock protein A
HUE56_RS21845	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HUE56_RS21850	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HUE56_RS21860	COG0825	malonyl-CoA metabolic process
HUE56_RS21915	COG2202	Pas domain
HUE56_RS21915	COG2205	protein histidine kinase activity
HUE56_RS21930	COG0560	Phosphoserine phosphatase
HUE56_RS21930	COG3830	Belongs to the UPF0237 family
HUE56_RS21940	COG1595	DNA-templated transcription, initiation
HUE56_RS21945	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUE56_RS21960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUE56_RS21970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUE56_RS21985	COG1695	Transcriptional regulator
HUE56_RS21995	COG0492	ferredoxin-NADP+ reductase activity
HUE56_RS22000	COG0601	transmembrane transport
HUE56_RS22010	COG0444	Belongs to the ABC transporter superfamily
HUE56_RS22015	COG4608	Belongs to the ABC transporter superfamily
HUE56_RS22040	COG0583	DNA-binding transcription factor activity
HUE56_RS22060	COG4566	intracellular signal transduction
HUE56_RS22075	COG0459	protein refolding
HUE56_RS22080	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUE56_RS22085	COG5425	PFAM Usg family protein
HUE56_RS22095	COG3772	lysozyme
HUE56_RS22100	COG1612	heme a metabolic process
HUE56_RS22105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUE56_RS22140	COG3278	Belongs to the heme-copper respiratory oxidase family
HUE56_RS22150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUE56_RS22170	COG1177	transmembrane transport
HUE56_RS22190	COG0156	8-amino-7-oxononanoate synthase activity
HUE56_RS22200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUE56_RS22210	COG0135	phosphoribosylanthranilate isomerase activity
HUE56_RS22225	COG5265	(ABC) transporter
HUE56_RS22230	COG0840	transmembrane signaling receptor activity
HUE56_RS22235	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS22250	COG1793	dna ligase
HUE56_RS22260	COG2313	pseudouridylate synthase activity
HUE56_RS22285	COG1741	Belongs to the pirin family
HUE56_RS22290	COG0004	ammonium transporteR
HUE56_RS22295	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUE56_RS22300	COG0297	glycogen (starch) synthase activity
HUE56_RS22320	COG0252	asparaginase activity
HUE56_RS22340	COG3437	response regulator, receiver
HUE56_RS22340	COG0784	Response regulator, receiver
HUE56_RS22355	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUE56_RS22360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUE56_RS22365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUE56_RS22370	COG1139	Iron-sulfur cluster binding protein
HUE56_RS22375	COG0247	lactate metabolic process
HUE56_RS22385	COG1620	l-lactate permease
HUE56_RS22390	COG2186	Transcriptional regulator
HUE56_RS22395	COG2204	response regulator
HUE56_RS22410	COG0372	Belongs to the citrate synthase family
HUE56_RS22425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE56_RS22425	COG2205	protein histidine kinase activity
HUE56_RS22440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE56_RS22455	COG1737	Transcriptional regulator
HUE56_RS22470	COG3604	Transcriptional regulator
HUE56_RS22480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HUE56_RS22485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HUE56_RS22500	COG3604	Transcriptional regulator
HUE56_RS22510	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HUE56_RS22520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUE56_RS22525	COG1063	alcohol dehydrogenase
HUE56_RS22530	COG0246	Mannitol dehydrogenase
HUE56_RS22535	COG1802	Transcriptional regulator
HUE56_RS22540	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUE56_RS22560	COG0784	Response regulator, receiver
HUE56_RS22560	COG5002	protein histidine kinase activity
HUE56_RS22560	COG2205	protein histidine kinase activity
HUE56_RS22570	COG3416	Protein conserved in bacteria
HUE56_RS22580	COG3920	Histidine kinase
HUE56_RS22590	COG5265	(ABC) transporter
HUE56_RS22595	COG1032	radical SAM domain protein
HUE56_RS22615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUE56_RS22625	COG0573	inorganic phosphate transmembrane transporter activity
HUE56_RS22630	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUE56_RS22645	COG0625	glutathione transferase activity
HUE56_RS22650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUE56_RS22685	COG2814	Major facilitator Superfamily
HUE56_RS22700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUE56_RS22720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUE56_RS22735	COG2885	chlorophyll binding
HUE56_RS22735	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HUE56_RS22790	COG1940	carbohydrate kinase activity
HUE56_RS22810	COG0463	Glycosyl transferase, family 2
HUE56_RS22830	COG4191	Histidine kinase
HUE56_RS22830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE56_RS22850	COG1858	cytochrome C peroxidase
HUE56_RS22865	COG4191	Histidine kinase
HUE56_RS22890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUE56_RS22915	COG3842	ATPase activity
HUE56_RS22920	COG3842	ATPase activity
HUE56_RS22940	COG1349	DNA-binding transcription factor activity
HUE56_RS22990	COG0697	spore germination
HUE56_RS23000	COG0569	domain protein
HUE56_RS23005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUE56_RS23060	COG1116	anion transmembrane transporter activity
HUE56_RS23065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUE56_RS23070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUE56_RS23075	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUE56_RS23085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUE56_RS23095	COG0791	NLP P60 protein
HUE56_RS23100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUE56_RS23100	COG1648	precorrin-2 dehydrogenase activity
HUE56_RS23105	COG0243	molybdopterin cofactor binding
HUE56_RS23115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUE56_RS23120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUE56_RS23130	COG1116	anion transmembrane transporter activity
HUE56_RS23135	COG0656	L-ascorbic acid biosynthetic process
HUE56_RS23145	COG1752	Esterase of the alpha-beta hydrolase superfamily
HUE56_RS23175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUE56_RS23180	COG2017	converts alpha-aldose to the beta-anomer
HUE56_RS23185	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUE56_RS23190	COG1129	ABC transporter
HUE56_RS23195	COG1879	ABC-type sugar transport system periplasmic component
HUE56_RS23235	COG4214	carbohydrate transport
HUE56_RS23245	COG0840	transmembrane signaling receptor activity
HUE56_RS23250	COG0129	dihydroxy-acid dehydratase activity
HUE56_RS23260	COG1966	Carbon starvation protein
HUE56_RS23265	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS23285	COG1295	ribonuclease BN
HUE56_RS23290	COG1794	racemase activity, acting on amino acids and derivatives
HUE56_RS23295	COG3279	Response regulator of the LytR AlgR family
HUE56_RS23300	COG3275	phosphorelay sensor kinase activity
HUE56_RS23310	COG0318	PFAM AMP-dependent synthetase and ligase
HUE56_RS23320	COG0644	oxidoreductase
HUE56_RS23330	COG0583	DNA-binding transcription factor activity
HUE56_RS23345	COG1192	Involved in chromosome partitioning
HUE56_RS23365	COG4221	oxidoreductase activity
HUE56_RS23365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUE56_RS23365	COG0604	alcohol dehydrogenase
HUE56_RS23365	COG3321	synthase
HUE56_RS23380	COG1686	Belongs to the peptidase S11 family
HUE56_RS23390	COG1609	Transcriptional regulator
HUE56_RS23395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUE56_RS23400	COG1126	abc transporter atp-binding protein
HUE56_RS23405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE56_RS23410	COG0765	amino acid transport
HUE56_RS23415	COG0765	amino acid transport
HUE56_RS23420	COG2814	Major facilitator Superfamily
HUE56_RS23425	COG1487	ribonuclease activity
HUE56_RS23440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUE56_RS23445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUE56_RS23460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUE56_RS23505	COG1706	bacterial-type flagellum-dependent cell motility
HUE56_RS23515	COG1256	bacterial-type flagellum assembly
HUE56_RS23520	COG1749	Flagellar hook protein flgE
HUE56_RS23530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUE56_RS23540	COG4786	Flagellar basal body rod
HUE56_RS23545	COG4786	Flagellar basal body rod
HUE56_RS23550	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HUE56_RS23555	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HUE56_RS23595	COG1766	The M ring may be actively involved in energy transduction
HUE56_RS23605	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUE56_RS23610	COG1338	Plays a role in the flagellum-specific transport system
HUE56_RS23620	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUE56_RS23635	COG0745	RESPONSE REGULATOR receiver
HUE56_RS23640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUE56_RS23645	COG5442	Flagellar protein FlaF
HUE56_RS23650	COG5443	negative regulation of bacterial-type flagellum assembly
HUE56_RS23670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUE56_RS23695	COG1558	bacterial-type flagellum-dependent cell motility
HUE56_RS23700	COG1677	Flagellar hook-basal body complex protein FliE
HUE56_RS23715	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUE56_RS23725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUE56_RS23740	COG2814	Major facilitator Superfamily
HUE56_RS23750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUE56_RS23755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUE56_RS23760	COG0351	phosphomethylpyrimidine kinase
HUE56_RS23765	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HUE56_RS23795	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HUE56_RS23800	COG1845	cytochrome c oxidase, subunit III
HUE56_RS23805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUE56_RS23810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUE56_RS23815	COG0477	Major facilitator Superfamily
HUE56_RS23850	COG1988	membrane-bound metal-dependent
HUE56_RS23875	COG2814	Major facilitator Superfamily
HUE56_RS23890	COG4178	(ABC) transporter
HUE56_RS23905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUE56_RS23915	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUE56_RS23935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUE56_RS23960	COG4993	Dehydrogenase
HUE56_RS23965	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUE56_RS23975	COG2086	electron transfer activity
HUE56_RS23990	COG2723	6-phospho-beta-galactosidase activity
HUE56_RS24015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUE56_RS24020	COG1127	ABC transporter
HUE56_RS24025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUE56_RS24045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUE56_RS24050	COG0305	Participates in initiation and elongation during chromosome replication
HUE56_RS24065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUE56_RS24065	COG2010	Cytochrome c
HUE56_RS24085	COG0598	Magnesium transport protein CorA
HUE56_RS24100	COG0840	transmembrane signaling receptor activity
HUE56_RS24135	COG0110	maltose O-acetyltransferase activity
HUE56_RS24145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUE56_RS24165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUE56_RS24170	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUE56_RS24175	COG1127	ABC transporter
HUE56_RS24180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HUE56_RS24180	COG3218	ABC-type transport auxiliary lipoprotein component
HUE56_RS24200	COG2202	Pas domain
HUE56_RS24200	COG2205	protein histidine kinase activity
HUE56_RS24210	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HUE56_RS24225	COG2703	oxygen carrier activity
HUE56_RS24240	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUE56_RS24245	COG0741	lytic transglycosylase activity
HUE56_RS24250	COG1573	uracil-dna glycosylase
HUE56_RS24270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUE56_RS24290	COG0859	PFAM glycosyl transferase family 9
HUE56_RS24290	COG0457	Tetratricopeptide repeat
HUE56_RS24300	COG0280	phosphate acetyltransferase
HUE56_RS24300	COG0281	malic enzyme
HUE56_RS24305	COG1301	dicarboxylic acid transport
HUE56_RS24310	COG4191	Histidine kinase
HUE56_RS24315	COG2204	response regulator
HUE56_RS24325	COG1640	4-alpha-glucanotransferase
HUE56_RS24350	COG1024	Enoyl-CoA hydratase
HUE56_RS24385	COG0318	PFAM AMP-dependent synthetase and ligase
HUE56_RS24395	COG0625	glutathione transferase activity
HUE56_RS24415	COG0737	Belongs to the 5'-nucleotidase family
HUE56_RS24420	COG4191	Histidine kinase
HUE56_RS24420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE56_RS24445	COG1749	Flagellar hook protein flgE
HUE56_RS24445	COG1749	Flagellar hook protein flgE
HUE56_RS24460	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HUE56_RS24465	COG0366	Alpha amylase catalytic
HUE56_RS24480	COG1558	bacterial-type flagellum-dependent cell motility
HUE56_RS24500	COG2226	methyltransferase
HUE56_RS24505	COG0859	PFAM glycosyl transferase family 9
HUE56_RS24505	COG0457	Tetratricopeptide repeat
HUE56_RS24520	COG0457	Tetratricopeptide repeat
HUE56_RS24520	COG0859	PFAM glycosyl transferase family 9
HUE56_RS24535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUE56_RS24540	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS24545	COG0318	PFAM AMP-dependent synthetase and ligase
HUE56_RS24565	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HUE56_RS24570	COG2089	acid synthase
HUE56_RS24590	COG5002	protein histidine kinase activity
HUE56_RS24605	COG0588	phosphoglycerate mutase activity
HUE56_RS24610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUE56_RS24625	COG3693	PFAM glycoside hydrolase, family 10
HUE56_RS24635	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HUE56_RS24640	COG1045	serine acetyltransferase
HUE56_RS24660	COG1216	Glycosyl transferase, family 2
HUE56_RS24665	COG0438	transferase activity, transferring glycosyl groups
HUE56_RS24670	COG0438	transferase activity, transferring glycosyl groups
HUE56_RS24685	COG0318	PFAM AMP-dependent synthetase and ligase
HUE56_RS24690	COG0367	asparagine synthase
HUE56_RS24695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUE56_RS24720	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HUE56_RS24725	COG4208	sulfate ABC transporter
HUE56_RS24735	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HUE56_RS24785	COG2226	methyltransferase
HUE56_RS24800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUE56_RS24810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUE56_RS24815	COG1846	Transcriptional regulator
HUE56_RS24825	COG3707	response regulator
HUE56_RS24855	COG3842	ATPase activity
HUE56_RS24865	COG1840	ABC-type Fe3 transport system, periplasmic component
HUE56_RS24885	COG1335	isochorismatase
HUE56_RS24890	COG3791	Glutathione-dependent formaldehyde-activating
HUE56_RS24900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUE56_RS24905	COG0367	asparagine synthase
HUE56_RS24910	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUE56_RS24910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUE56_RS24915	COG1363	Peptidase, m42
HUE56_RS24930	COG5002	protein histidine kinase activity
HUE56_RS24930	COG0784	Response regulator, receiver
HUE56_RS24935	COG0745	RESPONSE REGULATOR receiver
HUE56_RS24950	COG0840	transmembrane signaling receptor activity
HUE56_RS24960	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HUE56_RS24970	COG2030	dehydratase
HUE56_RS24970	COG1012	belongs to the aldehyde dehydrogenase family
HUE56_RS24980	COG5002	protein histidine kinase activity
HUE56_RS24980	COG2198	Histidine kinase
HUE56_RS24980	COG0784	Response regulator, receiver
HUE56_RS24995	COG1253	flavin adenine dinucleotide binding
HUE56_RS25010	COG0784	Response regulator, receiver
HUE56_RS25010	COG2205	protein histidine kinase activity
HUE56_RS25010	COG2198	Histidine kinase
HUE56_RS25020	COG1396	sequence-specific DNA binding
HUE56_RS25025	COG1766	The M ring may be actively involved in energy transduction
HUE56_RS25035	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUE56_RS25040	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUE56_RS25045	COG2204	response regulator
HUE56_RS25050	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUE56_RS25070	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HUE56_RS25105	COG0745	RESPONSE REGULATOR receiver
HUE56_RS25110	COG2205	protein histidine kinase activity
HUE56_RS25135	COG0469	pyruvate kinase activity
HUE56_RS25140	COG3437	response regulator, receiver
HUE56_RS25140	COG0784	Response regulator, receiver
HUE56_RS25145	COG5001	Diguanylate cyclase
HUE56_RS25170	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUE56_RS25175	COG1177	transmembrane transport
HUE56_RS25180	COG3842	ATPase activity
HUE56_RS25185	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HUE56_RS25190	COG1840	ABC-type Fe3 transport system, periplasmic component
HUE56_RS25195	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUE56_RS25200	COG0673	inositol 2-dehydrogenase activity
HUE56_RS25205	COG0363	glucosamine-6-phosphate deaminase activity
HUE56_RS25210	COG1175	transmembrane transport
HUE56_RS25215	COG0395	ABC-type sugar transport system, permease component
HUE56_RS25225	COG2080	2 iron, 2 sulfur cluster binding
HUE56_RS25230	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUE56_RS25235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUE56_RS25250	COG0745	RESPONSE REGULATOR receiver
HUE56_RS25270	COG1063	alcohol dehydrogenase
HUE56_RS25280	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUE56_RS25285	COG0459	protein refolding
HUE56_RS25295	COG2133	pyrroloquinoline quinone binding
HUE56_RS25325	COG0798	PFAM Bile acid sodium symporter
HUE56_RS25330	COG1012	belongs to the aldehyde dehydrogenase family
HUE56_RS25330	COG1454	alcohol dehydrogenase
HUE56_RS25340	COG2814	Major facilitator Superfamily
HUE56_RS25360	COG2203	Gaf domain
HUE56_RS25360	COG3706	GGDEF domain
HUE56_RS25360	COG4251	negative regulation of phosphorylation
HUE56_RS25360	COG5001	Diguanylate cyclase
HUE56_RS25365	COG5383	Protein conserved in bacteria
HUE56_RS25375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUE56_RS25380	COG0517	IMP dehydrogenase activity
HUE56_RS25395	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUE56_RS25415	COG1446	asparaginase
HUE56_RS25420	COG2362	D-Aminopeptidase
HUE56_RS25430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUE56_RS25440	COG0747	negative chemotaxis
HUE56_RS25445	COG4172	Belongs to the ABC transporter superfamily
HUE56_RS25465	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUE56_RS25485	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HUE56_RS25490	COG1984	allophanate hydrolase subunit 2
HUE56_RS25500	COG3706	GGDEF domain
HUE56_RS25525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUE56_RS25535	COG0318	PFAM AMP-dependent synthetase and ligase
HUE56_RS25550	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUE56_RS25555	COG0574	Belongs to the PEP-utilizing enzyme family
HUE56_RS25555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUE56_RS25575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUE56_RS25605	COG0071	Belongs to the small heat shock protein (HSP20) family
HUE56_RS25615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUE56_RS25620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUE56_RS25625	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUE56_RS25625	COG0022	dehydrogenase e1 component
HUE56_RS25630	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUE56_RS25700	COG3597	protein domain associated with
HUE56_RS25715	COG4615	Cyclic peptide transporter
HUE56_RS25770	COG0163	prenyltransferase activity
HUE56_RS25775	COG0583	DNA-binding transcription factor activity
HUE56_RS25785	COG2188	Transcriptional regulator
HUE56_RS25790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUE56_RS25845	COG0511	ligase activity, forming carbon-carbon bonds
HUE56_RS25850	COG0439	Biotin carboxylase
HUE56_RS25860	COG1984	allophanate hydrolase subunit 2
HUE56_RS25865	COG1879	ABC-type sugar transport system periplasmic component
HUE56_RS25870	COG1129	ABC transporter
HUE56_RS25875	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUE56_RS25890	COG4584	PFAM Integrase catalytic
HUE56_RS25975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUE56_RS26000	COG0583	DNA-binding transcription factor activity
HUE56_RS26010	COG0183	Belongs to the thiolase family
HUE56_RS26015	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS26020	COG1024	Enoyl-CoA hydratase
HUE56_RS26040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUE56_RS26070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUE56_RS26085	COG1053	succinate dehydrogenase
HUE56_RS26090	COG1960	acyl-CoA dehydrogenase activity
HUE56_RS26095	COG1024	Enoyl-CoA hydratase
HUE56_RS26105	COG1802	Transcriptional regulator
HUE56_RS26145	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUE56_RS26175	COG1879	ABC-type sugar transport system periplasmic component
HUE56_RS26180	COG1129	ABC transporter
HUE56_RS26190	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUE56_RS26195	COG3386	PFAM SMP-30 Gluconolaconase
HUE56_RS26200	COG0277	FAD linked oxidase domain protein
HUE56_RS26215	COG0583	DNA-binding transcription factor activity
HUE56_RS26230	COG4670	ketone body catabolic process
HUE56_RS26240	COG1012	belongs to the aldehyde dehydrogenase family
HUE56_RS26245	COG1960	acyl-CoA dehydrogenase activity
HUE56_RS26250	COG0318	PFAM AMP-dependent synthetase and ligase
HUE56_RS26255	COG2086	electron transfer activity
HUE56_RS26300	COG3451	type IV secretory pathway VirB4
HUE56_RS26385	COG5489	Protein of unknown function (DUF736)
HUE56_RS26420	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HUE56_RS26440	COG0210	DNA helicase
HUE56_RS26465	COG2390	Transcriptional regulator
HUE56_RS26465	COG4584	PFAM Integrase catalytic
HUE56_RS26470	COG1484	DNA-dependent DNA replication
HUE56_RS26510	COG1475	DNA binding
HUE56_RS26520	COG4227	nucleotidyltransferase activity
HUE56_RS26540	COG1640	4-alpha-glucanotransferase
HUE56_RS26560	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUE56_RS26565	COG0366	Alpha amylase catalytic
HUE56_RS26585	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HUE56_RS26585	COG2885	chlorophyll binding
HUE56_RS26590	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HUE56_RS26595	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUE56_RS26600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUE56_RS26605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUE56_RS26625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUE56_RS26630	COG0583	DNA-binding transcription factor activity
HUE56_RS26635	COG0625	glutathione transferase activity
HUE56_RS26665	COG0411	ABC transporter
HUE56_RS26705	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUE56_RS26710	COG3383	formate dehydrogenase (NAD+) activity
HUE56_RS26725	COG0583	DNA-binding transcription factor activity
HUE56_RS26755	COG2205	protein histidine kinase activity
HUE56_RS26755	COG2198	Histidine kinase
HUE56_RS26755	COG0784	Response regulator, receiver
HUE56_RS26780	COG1475	DNA binding
HUE56_RS26785	COG1192	Involved in chromosome partitioning
HUE56_RS26810	COG2902	Dehydrogenase
HUE56_RS26830	COG0583	DNA-binding transcription factor activity
HUE56_RS26835	COG2205	protein histidine kinase activity
HUE56_RS26860	COG1960	acyl-CoA dehydrogenase activity
HUE56_RS26865	COG0183	Belongs to the thiolase family
HUE56_RS26870	COG1960	acyl-CoA dehydrogenase activity
HUE56_RS26875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUE56_RS26880	COG1024	Enoyl-CoA hydratase
HUE56_RS26885	COG4770	biotin carboxylase activity
HUE56_RS26905	COG2205	protein histidine kinase activity
HUE56_RS26915	COG0840	transmembrane signaling receptor activity
HUE56_RS26935	COG1309	transcriptional regulator
HUE56_RS26940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUE56_RS26980	COG0625	glutathione transferase activity
HUE56_RS26985	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUE56_RS26995	COG0640	Transcriptional regulator
HUE56_RS27010	COG0640	Transcriptional regulator
HUE56_RS27045	COG1902	pentaerythritol trinitrate reductase activity
HUE56_RS27055	COG4991	sh3 domain protein
HUE56_RS27055	COG0515	serine threonine protein kinase
HUE56_RS27055	COG3064	Membrane
HUE56_RS27060	COG3243	poly(R)-hydroxyalkanoic acid synthase
HUE56_RS27070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUE56_RS27080	COG0678	peroxiredoxin activity
HUE56_RS27090	COG0148	phosphopyruvate hydratase activity
HUE56_RS27095	COG0596	Alpha beta hydrolase
HUE56_RS27100	COG0728	peptidoglycan biosynthetic process
HUE56_RS27110	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUE56_RS27125	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUE56_RS27145	COG0546	phosphoglycolate phosphatase activity
HUE56_RS27185	COG0352	thiamine-phosphate diphosphorylase activity
HUE56_RS27190	COG1802	Transcriptional regulator
HUE56_RS27195	COG0469	pyruvate kinase activity
HUE56_RS27210	COG0574	Belongs to the PEP-utilizing enzyme family
HUE56_RS27210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUE56_RS27220	COG0517	IMP dehydrogenase activity
HUE56_RS27245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUE56_RS27250	COG0517	IMP dehydrogenase activity
HUE56_RS27280	COG2351	hydroxyisourate hydrolase activity
HUE56_RS27285	COG3960	tartronate-semialdehyde synthase activity
HUE56_RS27295	COG4221	oxidoreductase activity
HUE56_RS27300	COG2207	Transcriptional regulator
HUE56_RS27305	COG1414	Transcriptional regulator
HUE56_RS27310	COG1802	Transcriptional regulator
HUE56_RS27320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUE56_RS27325	COG0045	succinate-CoA ligase (ADP-forming) activity
HUE56_RS27335	COG1414	Transcriptional regulator
HUE56_RS27340	COG0604	alcohol dehydrogenase
HUE56_RS27340	COG3321	synthase
HUE56_RS27340	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS27375	COG0784	Response regulator, receiver
HUE56_RS27395	COG0697	spore germination
HUE56_RS27400	COG0747	negative chemotaxis
HUE56_RS27405	COG0601	transmembrane transport
HUE56_RS27410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUE56_RS27415	COG0444	Belongs to the ABC transporter superfamily
HUE56_RS27420	COG4608	Belongs to the ABC transporter superfamily
HUE56_RS27430	COG1666	GTP binding
HUE56_RS27455	COG2890	protein-(glutamine-N5) methyltransferase activity
HUE56_RS27465	COG0142	geranyltranstransferase activity
HUE56_RS27485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUE56_RS27500	COG2860	membrane
HUE56_RS27510	COG2217	Heavy metal translocating P-type atpase
HUE56_RS27515	COG0789	Transcriptional regulator
HUE56_RS27530	COG2814	Major facilitator Superfamily
HUE56_RS27550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUE56_RS27560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUE56_RS27565	COG0402	S-adenosylhomocysteine deaminase activity
HUE56_RS27575	COG4603	Belongs to the binding-protein-dependent transport system permease family
HUE56_RS27595	COG1414	Transcriptional regulator
HUE56_RS27600	COG3842	ATPase activity
HUE56_RS27605	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUE56_RS27610	COG1177	transmembrane transport
HUE56_RS27635	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUE56_RS27640	COG2223	nitrite transmembrane transporter activity
HUE56_RS27645	COG3546	catalase activity
HUE56_RS27670	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HUE56_RS27675	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUE56_RS27680	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HUE56_RS27685	COG0295	cytidine deaminase activity
HUE56_RS27700	COG3411	Ferredoxin
HUE56_RS27705	COG0697	spore germination
HUE56_RS27715	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUE56_RS27755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUE56_RS27785	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUE56_RS27800	COG0740	serine-type endopeptidase activity
HUE56_RS27805	COG0463	Glycosyl transferase, family 2
HUE56_RS27820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUE56_RS27840	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUE56_RS27860	COG0308	aminopeptidase N
HUE56_RS27910	COG0316	Belongs to the HesB IscA family
HUE56_RS27915	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUE56_RS27930	COG1472	Belongs to the glycosyl hydrolase 3 family
HUE56_RS27935	COG1994	Peptidase M50
HUE56_RS27940	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUE56_RS27945	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUE56_RS27950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUE56_RS27955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUE56_RS27960	COG0805	protein transport
HUE56_RS27965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUE56_RS27985	COG0420	3'-5' exonuclease activity
HUE56_RS28055	COG1074	ATP-dependent DNA helicase activity
HUE56_RS28060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUE56_RS28070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUE56_RS28115	COG4974	Belongs to the 'phage' integrase family
HUE56_RS28145	COG1396	sequence-specific DNA binding
HUE56_RS28155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUE56_RS28180	COG1201	RNA secondary structure unwinding
HUE56_RS28255	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUE56_RS28260	COG1177	transmembrane transport
HUE56_RS28265	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS28270	COG1802	Transcriptional regulator
HUE56_RS28275	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUE56_RS28280	COG3958	Transketolase
HUE56_RS28285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HUE56_RS28290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUE56_RS28300	COG3842	ATPase activity
HUE56_RS28310	COG1024	Enoyl-CoA hydratase
HUE56_RS28310	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUE56_RS28315	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS28325	COG3806	Anti-sigma factor
HUE56_RS28330	COG1595	DNA-templated transcription, initiation
HUE56_RS28335	COG0477	Major facilitator Superfamily
HUE56_RS28340	COG1024	Enoyl-CoA hydratase
HUE56_RS28345	COG0183	Belongs to the thiolase family
HUE56_RS28350	COG4175	Glycine betaine
HUE56_RS28355	COG4176	ABC-type proline glycine betaine transport system permease component
HUE56_RS28375	COG0747	negative chemotaxis
HUE56_RS28380	COG3437	response regulator, receiver
HUE56_RS28380	COG0784	Response regulator, receiver
HUE56_RS28385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUE56_RS28410	COG0737	Belongs to the 5'-nucleotidase family
HUE56_RS28415	COG0505	Belongs to the CarA family
HUE56_RS28420	COG2068	MobA-Related Protein
HUE56_RS28425	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HUE56_RS28470	COG2358	TRAP transporter, solute receptor (TAXI family
HUE56_RS28510	COG3437	response regulator, receiver
HUE56_RS28510	COG2770	Histidine kinase
HUE56_RS28515	COG3012	SEC-C Motif Domain Protein
HUE56_RS28525	COG1448	Aminotransferase
HUE56_RS28535	COG3483	tryptophan 2,3-dioxygenase activity
HUE56_RS28555	COG1845	cytochrome c oxidase, subunit III
HUE56_RS28565	COG3256	nitric oxide reductase
HUE56_RS28570	COG0714	Associated with various cellular activities
HUE56_RS28580	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUE56_RS28590	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HUE56_RS28595	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HUE56_RS28600	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HUE56_RS28615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUE56_RS28655	COG0297	glycogen (starch) synthase activity
HUE56_RS28670	COG3106	COG3106 Predicted ATPase
HUE56_RS28675	COG3768	UPF0283 membrane protein
HUE56_RS28680	COG1741	Belongs to the pirin family
HUE56_RS28685	COG2205	protein histidine kinase activity
HUE56_RS28685	COG0784	Response regulator, receiver
HUE56_RS28690	COG0564	pseudouridine synthase activity
HUE56_RS28705	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HUE56_RS28705	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HUE56_RS28715	COG1028	Short-chain dehydrogenase reductase Sdr
HUE56_RS28720	COG2271	Major facilitator Superfamily
HUE56_RS28725	COG1522	sequence-specific DNA binding
HUE56_RS28765	COG2169	Transcriptional regulator
HUE56_RS28765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUE56_RS28780	COG1131	(ABC) transporter
HUE56_RS28795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE56_RS28850	COG2273	Hydrolase Family 16
HUE56_RS28855	COG0772	Belongs to the SEDS family
HUE56_RS28860	COG3706	GGDEF domain
HUE56_RS28865	COG1309	transcriptional regulator
HUE56_RS28885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUE56_RS28890	COG0393	Putative heavy-metal-binding
HUE56_RS28920	COG1280	lysine exporter protein (LysE YggA)
HUE56_RS28925	COG2183	response to ionizing radiation
HUE56_RS28950	COG4251	negative regulation of phosphorylation
HUE56_RS28955	COG0784	Response regulator, receiver
HUE56_RS28960	COG2202	Pas domain
HUE56_RS28960	COG3920	Histidine kinase
HUE56_RS28965	COG0784	Response regulator, receiver
HUE56_RS28975	COG2847	Copper chaperone PCu(A)C
HUE56_RS29010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUE56_RS29015	COG4520	surface antigen
HUE56_RS29025	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUE56_RS29065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUE56_RS29105	COG4214	carbohydrate transport
HUE56_RS29120	COG0673	inositol 2-dehydrogenase activity
HUE56_RS29125	COG0673	inositol 2-dehydrogenase activity
HUE56_RS29135	COG3485	protocatechuate 3,4-dioxygenase
HUE56_RS29140	COG2963	transposase activity
HUE56_RS29150	COG3344	reverse transcriptase
HUE56_RS29165	COG0583	DNA-binding transcription factor activity
HUE56_RS29180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HUE56_RS29200	COG3344	reverse transcriptase
HUE56_RS29225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUE56_RS29270	COG4372	Transposase
HUE56_RS29275	COG3436	PFAM IS66 Orf2 family protein
HUE56_RS29300	COG1475	DNA binding
HUE56_RS29320	COG1396	sequence-specific DNA binding
HUE56_RS29365	COG1475	DNA binding
HUE56_RS29480	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUE56_RS29550	COG0681	Belongs to the peptidase S26 family
HUE56_RS29670	COG0501	Belongs to the peptidase M48B family
HUE56_RS29765	COG0583	DNA-binding transcription factor activity
HUE56_RS29770	COG1063	alcohol dehydrogenase
HUE56_RS29885	COG3437	response regulator, receiver
HUE56_RS29885	COG2770	Histidine kinase
HUE56_RS29900	COG1484	DNA-dependent DNA replication
HUE56_RS29905	COG4584	PFAM Integrase catalytic
HUE56_RS29985	COG3436	PFAM IS66 Orf2 family protein
HUE56_RS30100	COG3436	PFAM IS66 Orf2 family protein
HUE56_RS30105	COG4372	Transposase
HUE56_RS30110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUE56_RS30115	COG4957	zinc ion binding
HUE56_RS30145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUE56_RS30310	COG0586	Pfam SNARE associated Golgi protein
HUE56_RS30315	COG0671	phosphoesterase, PA-phosphatase related
HUE56_RS30320	COG0586	Pfam SNARE associated Golgi protein
HUE56_RS30325	COG5002	protein histidine kinase activity
HUE56_RS30340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUE56_RS30365	COG1937	Protein conserved in bacteria
HUE56_RS30390	COG0671	phosphoesterase, PA-phosphatase related
HUE56_RS30455	COG3258	Cytochrome c
HUE56_RS30480	COG2132	Multicopper oxidase
HUE56_RS30500	COG0745	RESPONSE REGULATOR receiver
HUE56_RS30505	COG0745	RESPONSE REGULATOR receiver