locus-tag	class	description
DM194_RS00035	COG1509	lysine 2,3-aminomutase activity
DM194_RS00040	COG0584	glycerophosphoryl diester phosphodiesterase
DM194_RS00065	COG2202	Pas domain
DM194_RS00065	COG2205	protein histidine kinase activity
DM194_RS00080	COG3162	membrane
DM194_RS00095	COG0318	PFAM AMP-dependent synthetase and ligase
DM194_RS00100	COG2086	electron transfer activity
DM194_RS00110	COG1960	acyl-CoA dehydrogenase activity
DM194_RS00115	COG1187	pseudouridine synthase activity
DM194_RS00130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DM194_RS00145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DM194_RS00150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DM194_RS00155	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DM194_RS00180	COG0583	DNA-binding transcription factor activity
DM194_RS00190	COG0252	asparaginase activity
DM194_RS00205	COG0297	glycogen (starch) synthase activity
DM194_RS00210	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DM194_RS00215	COG0004	ammonium transporteR
DM194_RS00220	COG1741	Belongs to the pirin family
DM194_RS00245	COG2313	pseudouridylate synthase activity
DM194_RS00255	COG1793	dna ligase
DM194_RS00270	COG3660	Nucleoside-diphosphate-sugar epimerase
DM194_RS00275	COG1522	sequence-specific DNA binding
DM194_RS00290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DM194_RS00295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DM194_RS00315	COG3005	denitrification pathway
DM194_RS00370	COG2318	DinB family
DM194_RS00375	COG1674	ftsk spoiiie
DM194_RS00385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DM194_RS00395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DM194_RS00400	COG1238	metal cluster binding
DM194_RS00455	COG0539	negative regulation of cytoplasmic translation
DM194_RS00470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DM194_RS00480	COG0574	Belongs to the PEP-utilizing enzyme family
DM194_RS00480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DM194_RS00485	COG1396	sequence-specific DNA binding
DM194_RS00490	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
DM194_RS00500	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DM194_RS00520	COG1643	Atp-dependent helicase
DM194_RS00555	COG4191	Histidine kinase
DM194_RS00580	COG0045	succinate-CoA ligase (ADP-forming) activity
DM194_RS00585	COG0039	L-malate dehydrogenase activity
DM194_RS00605	COG2076	Multidrug Resistance protein
DM194_RS00610	COG0640	Transcriptional regulator
DM194_RS00625	COG1970	mechanosensitive ion channel activity
DM194_RS00630	COG0653	protein targeting
DM194_RS00635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DM194_RS00640	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DM194_RS00645	COG0494	nUDIX hydrolase
DM194_RS00650	COG0514	ATP-dependent DNA helicase (RecQ)
DM194_RS00665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DM194_RS00670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DM194_RS00675	COG0842	Transport permease protein
DM194_RS00680	COG2137	regulation of response to DNA damage stimulus
DM194_RS00685	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DM194_RS00695	COG1703	isobutyryl-CoA mutase activity
DM194_RS00700	COG4172	Belongs to the ABC transporter superfamily
DM194_RS00705	COG4239	(ABC) transporter, permease
DM194_RS00710	COG4174	ABC transporter (Permease)
DM194_RS00715	COG4166	transmembrane transport
DM194_RS00735	COG2816	NAD+ diphosphatase activity
DM194_RS00745	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DM194_RS00750	COG3474	cytochrome
DM194_RS00765	COG2766	serine protein kinase
DM194_RS00770	COG2718	Belongs to the UPF0229 family
DM194_RS00775	COG2719	SpoVR family
DM194_RS00785	COG0318	PFAM AMP-dependent synthetase and ligase
DM194_RS00790	COG1254	Belongs to the acylphosphatase family
DM194_RS00820	COG2239	Acts as a magnesium transporter
DM194_RS00830	COG2022	thiamine diphosphate biosynthetic process
DM194_RS00840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM194_RS00840	COG2022	thiamine diphosphate biosynthetic process
DM194_RS00845	COG0840	transmembrane signaling receptor activity
DM194_RS00905	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DM194_RS00910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM194_RS00915	COG0583	DNA-binding transcription factor activity
DM194_RS00920	COG5383	Protein conserved in bacteria
DM194_RS00925	COG5001	Diguanylate cyclase
DM194_RS00925	COG3300	MHYT domain
DM194_RS00970	COG3436	PFAM IS66 Orf2 family protein
DM194_RS00975	COG4372	Transposase
DM194_RS00980	COG0531	amino acid
DM194_RS00990	COG0531	amino acid
DM194_RS00995	COG0076	glutamate decarboxylase activity
DM194_RS01000	COG1064	alcohol dehydrogenase
DM194_RS01020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DM194_RS01025	COG3108	Peptidase M15
DM194_RS01030	COG2003	Belongs to the UPF0758 family
DM194_RS01035	COG3038	cytochrome b561
DM194_RS01040	COG2205	protein histidine kinase activity
DM194_RS01045	COG0745	RESPONSE REGULATOR receiver
DM194_RS01050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DM194_RS01055	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DM194_RS01070	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DM194_RS01075	COG0277	FAD linked oxidase domain protein
DM194_RS01080	COG0277	FAD linked oxidase domain protein
DM194_RS01085	COG0247	lactate metabolic process
DM194_RS01105	COG1454	alcohol dehydrogenase
DM194_RS01130	COG0310	cobalt ion transport
DM194_RS01140	COG0864	Transcriptional regulator
DM194_RS01150	COG0004	ammonium transporteR
DM194_RS01160	COG0829	nickel cation binding
DM194_RS01165	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DM194_RS01170	COG0830	nickel cation binding
DM194_RS01190	COG0804	urea catabolic process
DM194_RS01200	COG0831	urea catabolic process
DM194_RS01205	COG1960	acyl-CoA dehydrogenase activity
DM194_RS01225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DM194_RS01230	COG2171	N-acyltransferase activity
DM194_RS01265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DM194_RS01270	COG0228	four-way junction DNA binding
DM194_RS01275	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DM194_RS01280	COG0336	Belongs to the RNA methyltransferase TrmD family
DM194_RS01285	COG0335	large ribosomal subunit rRNA binding
DM194_RS01290	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DM194_RS01300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DM194_RS01305	COG0706	membrane insertase activity
DM194_RS01310	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DM194_RS01320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DM194_RS01330	COG0598	Magnesium transport protein CorA
DM194_RS01335	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DM194_RS01345	COG1530	ribonuclease E activity
DM194_RS01385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DM194_RS01385	COG0561	phosphatase activity
DM194_RS01400	COG1940	carbohydrate kinase activity
DM194_RS01425	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DM194_RS01430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM194_RS01435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM194_RS01470	COG0559	Belongs to the binding-protein-dependent transport system permease family
DM194_RS01515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DM194_RS01535	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DM194_RS01540	COG0081	regulation of translation
DM194_RS01545	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DM194_RS01550	COG0222	ribosome binding
DM194_RS01555	COG0085	RNA polymerase activity
DM194_RS01560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DM194_RS01570	COG0049	tRNA binding
DM194_RS01580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DM194_RS01585	COG0051	transcription antitermination factor activity, RNA binding
DM194_RS01595	COG0088	Forms part of the polypeptide exit tunnel
DM194_RS01600	COG0089	rRNA binding
DM194_RS01605	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DM194_RS01610	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DM194_RS01615	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DM194_RS01620	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DM194_RS01625	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DM194_RS01630	COG0255	Belongs to the universal ribosomal protein uL29 family
DM194_RS01635	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DM194_RS01645	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DM194_RS01655	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DM194_RS01660	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DM194_RS01665	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DM194_RS01675	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DM194_RS01680	COG1841	ribosomal large subunit assembly
DM194_RS01685	COG0200	Binds to the 23S rRNA
DM194_RS01690	COG0201	protein transport
DM194_RS01695	COG0563	adenylate kinase activity
DM194_RS01705	COG0697	spore germination
DM194_RS01720	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DM194_RS01725	COG2873	o-acetylhomoserine
DM194_RS01735	COG2205	protein histidine kinase activity
DM194_RS01740	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DM194_RS01790	COG1285	pathogenesis
DM194_RS01795	COG2814	Major facilitator Superfamily
DM194_RS01800	COG0196	riboflavin kinase activity
DM194_RS01805	COG2030	dehydratase
DM194_RS01810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DM194_RS01825	COG0628	permease
DM194_RS01855	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DM194_RS01860	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DM194_RS01875	COG1280	lysine exporter protein (LysE YggA)
DM194_RS01885	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DM194_RS01885	COG1519	Transferase
DM194_RS01890	COG1663	tetraacyldisaccharide 4'-kinase activity
DM194_RS01895	COG1560	Kdo2-lipid A biosynthetic process
DM194_RS01920	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DM194_RS01925	COG0644	oxidoreductase
DM194_RS01980	COG1902	pentaerythritol trinitrate reductase activity
DM194_RS01990	COG2962	Rard protein
DM194_RS01995	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DM194_RS02005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DM194_RS02035	COG0395	ABC-type sugar transport system, permease component
DM194_RS02045	COG5508	conserved small protein
DM194_RS02050	COG0501	Belongs to the peptidase M48B family
DM194_RS02090	COG0784	Response regulator, receiver
DM194_RS02090	COG2205	protein histidine kinase activity
DM194_RS02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM194_RS02095	COG4191	Histidine kinase
DM194_RS02125	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DM194_RS02130	COG4372	Transposase
DM194_RS02135	COG3436	PFAM IS66 Orf2 family protein
DM194_RS02165	COG1686	Belongs to the peptidase S11 family
DM194_RS02180	COG2202	Pas domain
DM194_RS02180	COG2205	protein histidine kinase activity
DM194_RS02185	COG5002	protein histidine kinase activity
DM194_RS02190	COG2205	protein histidine kinase activity
DM194_RS02200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DM194_RS02215	COG0166	Belongs to the GPI family
DM194_RS02225	COG0612	Peptidase, M16
DM194_RS02230	COG0612	Peptidase, M16
DM194_RS02240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DM194_RS02270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DM194_RS02275	COG2703	oxygen carrier activity
DM194_RS02280	COG0840	transmembrane signaling receptor activity
DM194_RS02280	COG0840	transmembrane signaling receptor activity
DM194_RS02290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DM194_RS02305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DM194_RS02310	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DM194_RS02330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DM194_RS02335	COG0746	molybdenum cofactor guanylyltransferase activity
DM194_RS02360	COG3383	formate dehydrogenase (NAD+) activity
DM194_RS02360	COG0243	molybdopterin cofactor binding
DM194_RS02365	COG0437	4 iron, 4 sulfur cluster binding
DM194_RS02380	COG0235	Class ii aldolase
DM194_RS02385	COG5002	protein histidine kinase activity
DM194_RS02385	COG0784	Response regulator, receiver
DM194_RS02390	COG3384	dioxygenase
DM194_RS02400	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DM194_RS02405	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DM194_RS02410	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DM194_RS02415	COG0356	it plays a direct role in the translocation of protons across the membrane
DM194_RS02425	COG1999	signal sequence binding
DM194_RS02435	COG1702	phosphate starvation-inducible protein PhoH
DM194_RS02440	COG0850	regulation of cytokinetic process
DM194_RS02445	COG2894	cell division
DM194_RS02450	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DM194_RS02470	COG0840	transmembrane signaling receptor activity
DM194_RS02475	COG4948	Mandelate Racemase Muconate Lactonizing
DM194_RS02480	COG2154	pterin-4-alpha-carbinolamine dehydratase
DM194_RS02485	COG1573	uracil-dna glycosylase
DM194_RS02490	COG2264	protein methyltransferase activity
DM194_RS02500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DM194_RS02510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DM194_RS02520	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
DM194_RS02525	COG5420	small protein containing a coiled-coil domain
DM194_RS02540	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
DM194_RS02545	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
DM194_RS02585	COG0121	glutamine amidotransferase
DM194_RS02595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DM194_RS02600	COG0552	protein localization to endoplasmic reticulum
DM194_RS02605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DM194_RS02610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DM194_RS02655	COG2301	Belongs to the HpcH HpaI aldolase family
DM194_RS02660	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DM194_RS02665	COG2205	protein histidine kinase activity
DM194_RS02670	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DM194_RS02695	COG0508	dehydrogenase complex catalyzes the overall conversion of
DM194_RS02695	COG0596	Alpha beta hydrolase
DM194_RS02700	COG0022	dehydrogenase e1 component
DM194_RS02705	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DM194_RS02710	COG3199	ATP-NAD kinase
DM194_RS02715	COG0277	FAD linked oxidase domain protein
DM194_RS02725	COG1671	Belongs to the UPF0178 family
DM194_RS02730	COG0488	(ABC) transporter
DM194_RS02760	COG2853	Lipoprotein
DM194_RS02770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DM194_RS02780	COG1410	methionine synthase
DM194_RS02780	COG0646	methionine synthase
DM194_RS02800	COG3706	GGDEF domain
DM194_RS02815	COG2814	Major facilitator Superfamily
DM194_RS02825	COG0175	sulfate reduction
DM194_RS02830	COG0175	sulfate reduction
DM194_RS02835	COG1648	precorrin-2 dehydrogenase activity
DM194_RS02835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DM194_RS02845	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DM194_RS02860	COG3108	Peptidase M15
DM194_RS02870	COG2205	protein histidine kinase activity
DM194_RS02875	COG4566	intracellular signal transduction
DM194_RS02900	COG0243	molybdopterin cofactor binding
DM194_RS02905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DM194_RS02905	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DM194_RS02920	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DM194_RS02925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DM194_RS02935	COG0612	Peptidase, M16
DM194_RS02940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DM194_RS02960	COG0483	inositol monophosphate 1-phosphatase activity
DM194_RS02965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DM194_RS02980	COG0730	response to heat
DM194_RS02985	COG0352	thiamine-phosphate diphosphorylase activity
DM194_RS02990	COG1830	Aldolase
DM194_RS03040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DM194_RS03045	COG1692	metallophosphoesterase
DM194_RS03050	COG0217	transcriptional regulatory protein
DM194_RS03060	COG0632	four-way junction helicase activity
DM194_RS03065	COG2255	four-way junction helicase activity
DM194_RS03070	COG0824	Thioesterase
DM194_RS03080	COG0848	biopolymer transport protein
DM194_RS03095	COG2885	chlorophyll binding
DM194_RS03105	COG0037	tRNA processing
DM194_RS03110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DM194_RS03120	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DM194_RS03135	COG4520	surface antigen
DM194_RS03140	COG0259	pyridoxamine-phosphate oxidase activity
DM194_RS03155	COG1234	tRNA 3'-trailer cleavage
DM194_RS03160	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DM194_RS03165	COG2770	Histidine kinase
DM194_RS03165	COG3437	response regulator, receiver
DM194_RS03185	COG2153	protein acetylation
DM194_RS03200	COG3685	Protein conserved in bacteria
DM194_RS03215	COG4957	zinc ion binding
DM194_RS03220	COG0698	ribose 5-phosphate isomerase
DM194_RS03225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DM194_RS03230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DM194_RS03235	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DM194_RS03245	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DM194_RS03250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DM194_RS03260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DM194_RS03260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DM194_RS03270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DM194_RS03270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DM194_RS03290	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DM194_RS03295	COG0416	fatty acid biosynthetic process
DM194_RS03300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DM194_RS03340	COG1764	response to oxidative stress
DM194_RS03345	COG1846	Transcriptional regulator
DM194_RS03350	COG0456	acetyltransferase
DM194_RS03360	COG2890	protein-(glutamine-N5) methyltransferase activity
DM194_RS03365	COG1393	Belongs to the ArsC family
DM194_RS03370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DM194_RS03380	COG1403	HNH endonuclease
DM194_RS03385	COG0697	spore germination
DM194_RS03395	COG1610	YqeY-like protein
DM194_RS03410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DM194_RS03450	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DM194_RS03475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DM194_RS03485	COG3108	Peptidase M15
DM194_RS03505	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DM194_RS03510	COG0511	ligase activity, forming carbon-carbon bonds
DM194_RS03515	COG0439	Biotin carboxylase
DM194_RS03520	COG0840	transmembrane signaling receptor activity
DM194_RS03525	COG0745	RESPONSE REGULATOR receiver
DM194_RS03545	COG0432	Pfam Uncharacterised protein family UPF0047
DM194_RS03560	COG2205	protein histidine kinase activity
DM194_RS03565	COG0628	permease
DM194_RS03575	COG0105	UTP biosynthetic process
DM194_RS03595	COG0745	RESPONSE REGULATOR receiver
DM194_RS03615	COG2815	serine threonine protein kinase
DM194_RS03615	COG0515	serine threonine protein kinase
DM194_RS03640	COG0500	methyltransferase
DM194_RS03710	COG3501	Rhs element vgr protein
DM194_RS03760	COG2770	Histidine kinase
DM194_RS03760	COG2208	phosphoserine phosphatase activity
DM194_RS03765	COG1366	Belongs to the anti-sigma-factor antagonist family
DM194_RS03785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM194_RS03790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM194_RS03795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DM194_RS03800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DM194_RS03805	COG3237	CsbD-like
DM194_RS03820	COG1742	UPF0060 membrane protein
DM194_RS03830	COG5001	Diguanylate cyclase
DM194_RS03835	COG1840	ABC-type Fe3 transport system, periplasmic component
DM194_RS03840	COG3842	ATPase activity
DM194_RS03845	COG1132	(ABC) transporter
DM194_RS03865	COG1178	ABC-type Fe3 transport system permease component
DM194_RS03910	COG1561	YicC-like family, N-terminal region
DM194_RS03915	COG4221	oxidoreductase activity
DM194_RS03925	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DM194_RS03930	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DM194_RS03935	COG0052	Belongs to the universal ribosomal protein uS2 family
DM194_RS03940	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DM194_RS03945	COG0528	UMP kinase activity
DM194_RS03950	COG0233	cytoplasmic translational termination
DM194_RS03955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DM194_RS03965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DM194_RS03970	COG0750	zinc metalloprotease
DM194_RS03995	COG3494	Protein of unknown function (DUF1009)
DM194_RS04000	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DM194_RS04025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DM194_RS04030	COG2333	competence protein COMEC
DM194_RS04030	COG0658	competence protein
DM194_RS04035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DM194_RS04040	COG0303	'Molybdopterin
DM194_RS04045	COG0315	cyclic pyranopterin monophosphate synthase activity
DM194_RS04090	COG0739	heme binding
DM194_RS04090	COG0741	lytic transglycosylase activity
DM194_RS04090	COG1196	nuclear chromosome segregation
DM194_RS04095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DM194_RS04100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DM194_RS04105	COG2813	Specifically methylates the guanine in position
DM194_RS04115	COG0113	porphobilinogen synthase activity
DM194_RS04125	COG1597	lipid kinase activity
DM194_RS04130	COG1024	Enoyl-CoA hydratase
DM194_RS04135	COG1846	Transcriptional regulator
DM194_RS04155	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DM194_RS04170	COG0438	transferase activity, transferring glycosyl groups
DM194_RS04185	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS04190	COG2972	Histidine kinase
DM194_RS04190	COG0840	transmembrane signaling receptor activity
DM194_RS04200	COG0456	acetyltransferase
DM194_RS04205	COG0058	SHG alpha-glucan phosphorylase activity
DM194_RS04210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DM194_RS04215	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DM194_RS04235	COG2307	Protein conserved in bacteria
DM194_RS04235	COG2308	Evidence 4 Homologs of previously reported genes of
DM194_RS04240	COG2010	Cytochrome c
DM194_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS04270	COG0583	DNA-binding transcription factor activity
DM194_RS04330	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DM194_RS04335	COG2814	Major facilitator Superfamily
DM194_RS04340	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DM194_RS04350	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DM194_RS04365	COG1862	Preprotein translocase
DM194_RS04370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DM194_RS04380	COG3737	Protein of unknown function (DUF498/DUF598)
DM194_RS04385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DM194_RS04390	COG1233	COG1233 Phytoene dehydrogenase and related
DM194_RS04395	COG1562	ergosterol biosynthetic process
DM194_RS04400	COG1562	ergosterol biosynthetic process
DM194_RS04410	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DM194_RS04430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DM194_RS04440	COG2062	phosphohistidine phosphatase, SixA
DM194_RS04445	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DM194_RS04450	COG0248	Ppx GppA phosphatase
DM194_RS04480	COG0714	Associated with various cellular activities
DM194_RS04535	COG0640	Transcriptional regulator
DM194_RS04550	COG0730	response to heat
DM194_RS04555	COG0629	single-stranded DNA binding
DM194_RS04585	COG0123	including yeast histone deacetylase and acetoin utilization protein
DM194_RS04590	COG1116	anion transmembrane transporter activity
DM194_RS04595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM194_RS04600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DM194_RS04610	COG0483	inositol monophosphate 1-phosphatase activity
DM194_RS04625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DM194_RS04630	COG1923	regulation of RNA biosynthetic process
DM194_RS04640	COG2204	response regulator
DM194_RS04670	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DM194_RS04670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DM194_RS04675	COG1546	Belongs to the CinA family
DM194_RS04675	COG1058	Belongs to the CinA family
DM194_RS04680	COG1942	4-Oxalocrotonate Tautomerase
DM194_RS04685	COG2867	negative regulation of translational initiation
DM194_RS04690	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DM194_RS04700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DM194_RS04710	COG0508	dehydrogenase complex catalyzes the overall conversion of
DM194_RS04715	COG0022	dehydrogenase e1 component
DM194_RS04715	COG0508	dehydrogenase complex catalyzes the overall conversion of
DM194_RS04720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DM194_RS04740	COG4149	molybdate abc transporter
DM194_RS04745	COG0725	ABC transporter, periplasmic molybdate-binding protein
DM194_RS04750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DM194_RS04760	COG2261	transglycosylase associated protein
DM194_RS04775	COG2135	peptidase activity
DM194_RS04785	COG2200	EAL domain
DM194_RS04795	COG1218	3'(2'),5'-bisphosphate nucleotidase
DM194_RS04800	COG2833	Protein of unknown function (DUF455)
DM194_RS04805	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DM194_RS04810	COG0328	RNA-DNA hybrid ribonuclease activity
DM194_RS04815	COG0678	peroxiredoxin activity
DM194_RS04820	COG2824	Alkylphosphonate utilization operon protein PhnA
DM194_RS04825	COG4232	protein-disulfide reductase activity
DM194_RS04830	COG1678	Uncharacterized ACR, COG1678
DM194_RS04835	COG0314	molybdopterin synthase activity
DM194_RS04840	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DM194_RS04850	COG0546	phosphoglycolate phosphatase activity
DM194_RS04855	COG1763	Mo-molybdopterin cofactor biosynthetic process
DM194_RS04860	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DM194_RS04870	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS04895	COG4120	Belongs to the binding-protein-dependent transport system permease family
DM194_RS04900	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DM194_RS04925	COG0583	DNA-binding transcription factor activity
DM194_RS04930	COG0540	Belongs to the ATCase OTCase family
DM194_RS04935	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DM194_RS04945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DM194_RS04960	COG0776	regulation of translation
DM194_RS04965	COG4957	zinc ion binding
DM194_RS05010	COG0741	lytic transglycosylase activity
DM194_RS05015	COG0556	nucleotide-excision repair
DM194_RS05040	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DM194_RS05045	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DM194_RS05050	COG0509	glycine decarboxylation via glycine cleavage system
DM194_RS05065	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DM194_RS05070	COG1492	cobalamin metabolic process
DM194_RS05105	COG0534	Mate efflux family protein
DM194_RS05110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DM194_RS05115	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DM194_RS05145	COG0577	efflux transmembrane transporter activity
DM194_RS05145	COG1136	(ABC) transporter
DM194_RS05150	COG1136	(ABC) transporter
DM194_RS05155	COG1566	PFAM secretion protein HlyD family protein
DM194_RS05185	COG0149	triose-phosphate isomerase activity
DM194_RS05190	COG1846	Transcriptional regulator
DM194_RS05200	COG0745	RESPONSE REGULATOR receiver
DM194_RS05205	COG2205	protein histidine kinase activity
DM194_RS05245	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DM194_RS05250	COG1216	Glycosyl transferase, family 2
DM194_RS05255	COG1396	sequence-specific DNA binding
DM194_RS05295	COG1846	Transcriptional regulator
DM194_RS05300	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS05310	COG0628	permease
DM194_RS05315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DM194_RS05325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DM194_RS05330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DM194_RS05345	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DM194_RS05360	COG0024	Methionine aminopeptidase
DM194_RS05375	COG1160	GTP binding
DM194_RS05390	COG2197	response regulator
DM194_RS05400	COG3290	protein histidine kinase activity
DM194_RS05400	COG0840	transmembrane signaling receptor activity
DM194_RS05405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DM194_RS05460	COG3321	synthase
DM194_RS05460	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS05460	COG0604	alcohol dehydrogenase
DM194_RS05475	COG0288	reversible hydration of carbon dioxide
DM194_RS05495	COG0205	6-phosphofructokinase activity
DM194_RS05510	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DM194_RS05515	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DM194_RS05520	COG5001	Diguanylate cyclase
DM194_RS05540	COG0114	fumarate hydratase activity
DM194_RS05565	COG2951	lytic endotransglycosylase activity
DM194_RS05585	COG4191	Histidine kinase
DM194_RS05600	COG3346	SURF1 family
DM194_RS05610	COG1845	cytochrome c oxidase, subunit III
DM194_RS05615	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DM194_RS05625	COG0109	protoheme IX farnesyltransferase activity
DM194_RS05635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DM194_RS05635	COG1565	acr, cog1565
DM194_RS05645	COG0312	modulator of DNA gyrase
DM194_RS05650	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DM194_RS05655	COG2076	Multidrug Resistance protein
DM194_RS05665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DM194_RS05705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DM194_RS05720	COG1677	Flagellar hook-basal body complex protein FliE
DM194_RS05725	COG1558	bacterial-type flagellum-dependent cell motility
DM194_RS05735	COG2257	FlhB HrpN YscU SpaS Family
DM194_RS05750	COG1338	Plays a role in the flagellum-specific transport system
DM194_RS05760	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DM194_RS05770	COG1360	Flagellar Motor Protein
DM194_RS05785	COG1752	Esterase of the alpha-beta hydrolase superfamily
DM194_RS05795	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DM194_RS05810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DM194_RS05815	COG0571	ribonuclease III activity
DM194_RS05820	COG0681	Belongs to the peptidase S26 family
DM194_RS05825	COG0736	holo-[acyl-carrier-protein] synthase activity
DM194_RS05830	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DM194_RS05840	COG1758	RNA polymerase activity
DM194_RS05860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DM194_RS05870	COG1247	-acetyltransferase
DM194_RS05875	COG0519	Catalyzes the synthesis of GMP from XMP
DM194_RS05875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DM194_RS05920	COG1914	H( )-stimulated, divalent metal cation uptake system
DM194_RS05935	COG4953	penicillin-binding protein 1C
DM194_RS05940	COG2373	Large extracellular alpha-helical protein
DM194_RS05945	COG0583	DNA-binding transcription factor activity
DM194_RS05950	COG0303	'Molybdopterin
DM194_RS05955	COG1324	tolerance protein
DM194_RS05965	COG2205	protein histidine kinase activity
DM194_RS05975	COG1494	fructose-1,6-bisphosphatase
DM194_RS05985	COG0436	Aminotransferase
DM194_RS06000	COG0616	signal peptide processing
DM194_RS06005	COG0488	(ABC) transporter
DM194_RS06010	COG3932	Exopolysaccharide synthesis, ExoD
DM194_RS06020	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DM194_RS06025	COG0525	valine-tRNA ligase activity
DM194_RS06035	COG1538	Outer membrane efflux protein
DM194_RS06045	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DM194_RS06055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DM194_RS06075	COG3617	BRO family, N-terminal domain
DM194_RS06110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DM194_RS06115	COG0494	nUDIX hydrolase
DM194_RS06125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DM194_RS06130	COG2897	thiosulfate sulfurtransferase activity
DM194_RS06150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DM194_RS06155	COG1126	abc transporter atp-binding protein
DM194_RS06160	COG0765	amino acid transport
DM194_RS06165	COG4597	amino acid ABC transporter
DM194_RS06170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM194_RS06175	COG0626	cystathionine gamma-synthase activity
DM194_RS06195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DM194_RS06205	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DM194_RS06215	COG2308	Evidence 4 Homologs of previously reported genes of
DM194_RS06220	COG1360	Flagellar Motor Protein
DM194_RS06225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DM194_RS06245	COG0318	PFAM AMP-dependent synthetase and ligase
DM194_RS06250	COG0789	Transcriptional regulator
DM194_RS06260	COG2086	electron transfer activity
DM194_RS06275	COG2205	protein histidine kinase activity
DM194_RS06300	COG1765	OsmC-like protein
DM194_RS06305	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DM194_RS06315	COG5487	UPF0391 membrane protein
DM194_RS06325	COG0741	lytic transglycosylase activity
DM194_RS06340	COG2226	methyltransferase
DM194_RS06350	COG0513	Belongs to the DEAD box helicase family
DM194_RS06375	COG0187	DNA topoisomerase II activity
DM194_RS06380	COG1607	acyl-coa hydrolase
DM194_RS06390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DM194_RS06395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM194_RS06420	COG0784	Response regulator, receiver
DM194_RS06420	COG3437	response regulator, receiver
DM194_RS06430	COG0140	phosphoribosyl-ATP diphosphatase activity
DM194_RS06460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DM194_RS06465	COG2198	Histidine kinase
DM194_RS06465	COG0643	Histidine kinase
DM194_RS06470	COG2201	protein-glutamate methylesterase activity
DM194_RS06475	COG2201	protein-glutamate methylesterase activity
DM194_RS06480	COG0835	chemotaxis
DM194_RS06490	COG0840	transmembrane signaling receptor activity
DM194_RS06490	COG3290	protein histidine kinase activity
DM194_RS06495	COG3290	protein histidine kinase activity
DM194_RS06495	COG0840	transmembrane signaling receptor activity
DM194_RS06510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DM194_RS06515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DM194_RS06530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DM194_RS06540	COG0360	Binds together with S18 to 16S ribosomal RNA
DM194_RS06545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DM194_RS06555	COG0359	binds to the 23S rRNA
DM194_RS06560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DM194_RS06565	COG0538	isocitrate dehydrogenase activity
DM194_RS06575	COG0330	HflC and HflK could
DM194_RS06600	COG0473	3-isopropylmalate dehydrogenase activity
DM194_RS06630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DM194_RS06660	COG1686	Belongs to the peptidase S11 family
DM194_RS06665	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DM194_RS06670	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DM194_RS06680	COG0084	hydrolase, TatD family'
DM194_RS06685	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DM194_RS06685	COG0321	lipoyl(octanoyl) transferase activity
DM194_RS06700	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DM194_RS06730	COG1381	Involved in DNA repair and RecF pathway recombination
DM194_RS06735	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DM194_RS06760	COG4786	Flagellar basal body rod
DM194_RS06765	COG4786	Flagellar basal body rod
DM194_RS06775	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DM194_RS06845	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DM194_RS06850	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DM194_RS06860	COG1024	Enoyl-CoA hydratase
DM194_RS06875	COG0758	DNA mediated transformation
DM194_RS06880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DM194_RS06885	COG2264	protein methyltransferase activity
DM194_RS06890	COG1024	Enoyl-CoA hydratase
DM194_RS06895	COG1832	CoA-binding protein
DM194_RS06925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DM194_RS06955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DM194_RS06975	COG3447	MASE1 domain protein
DM194_RS06975	COG5001	Diguanylate cyclase
DM194_RS06975	COG5002	protein histidine kinase activity
DM194_RS06995	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DM194_RS07010	COG1238	metal cluster binding
DM194_RS07015	COG0203	ribosomal protein L17
DM194_RS07030	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DM194_RS07045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DM194_RS07050	COG0251	oxidation-reduction process
DM194_RS07055	COG3591	Belongs to the peptidase S1B family
DM194_RS07115	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DM194_RS07115	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DM194_RS07170	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DM194_RS07195	COG0154	amidase activity
DM194_RS07200	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DM194_RS07210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DM194_RS07220	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DM194_RS07245	COG0242	peptide deformylase activity
DM194_RS07250	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DM194_RS07255	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DM194_RS07260	COG1201	RNA secondary structure unwinding
DM194_RS07275	COG0415	Belongs to the DNA photolyase family
DM194_RS07280	COG0735	belongs to the Fur family
DM194_RS07285	COG0523	cobalamin synthesis protein
DM194_RS07300	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DM194_RS07315	COG2205	protein histidine kinase activity
DM194_RS07325	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DM194_RS07330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DM194_RS07330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DM194_RS07350	COG4251	negative regulation of phosphorylation
DM194_RS07355	COG0497	DNA recombination
DM194_RS07360	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DM194_RS07375	COG0745	RESPONSE REGULATOR receiver
DM194_RS07380	COG0006	proline dipeptidase activity
DM194_RS07390	COG2264	protein methyltransferase activity
DM194_RS07400	COG0210	DNA helicase
DM194_RS07405	COG2197	response regulator
DM194_RS07410	COG2197	response regulator
DM194_RS07435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DM194_RS07455	COG0742	ribosomal rna small subunit methyltransferase
DM194_RS07460	COG1187	pseudouridine synthase activity
DM194_RS07465	COG0590	tRNA wobble adenosine to inosine editing
DM194_RS07480	COG1570	exodeoxyribonuclease VII activity
DM194_RS07485	COG0418	dihydroorotase activity
DM194_RS07500	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS07505	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DM194_RS07510	COG0193	aminoacyl-tRNA hydrolase activity
DM194_RS07515	COG0012	GTP binding
DM194_RS07520	COG1283	sodium-dependent phosphate transmembrane transporter activity
DM194_RS07525	COG5001	Diguanylate cyclase
DM194_RS07525	COG3300	MHYT domain
DM194_RS07535	COG0583	DNA-binding transcription factor activity
DM194_RS07570	COG2945	thiolester hydrolase activity
DM194_RS07575	COG1045	serine acetyltransferase
DM194_RS07585	COG1104	cysteine desulfurase activity
DM194_RS07590	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DM194_RS07600	COG0482	sulfurtransferase activity
DM194_RS07615	COG3284	Transcriptional regulator
DM194_RS07660	COG2001	Belongs to the MraZ family
DM194_RS07665	COG0275	rRNA processing
DM194_RS07680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DM194_RS07690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DM194_RS07695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DM194_RS07705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DM194_RS07715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DM194_RS07720	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DM194_RS07725	COG1181	Belongs to the D-alanine--D-alanine ligase family
DM194_RS07730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DM194_RS07735	COG0849	cell division
DM194_RS07740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DM194_RS07755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DM194_RS07780	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DM194_RS07785	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DM194_RS07795	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DM194_RS07800	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DM194_RS07815	COG2954	triphosphatase activity
DM194_RS07835	COG1183	phosphatidylcholine synthase activity
DM194_RS07870	COG1129	ABC transporter
DM194_RS07875	COG0354	folic acid binding
DM194_RS07890	COG0546	phosphoglycolate phosphatase activity
DM194_RS07895	COG0564	pseudouridine synthase activity
DM194_RS07900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DM194_RS07905	COG1335	isochorismatase
DM194_RS07915	COG1136	(ABC) transporter
DM194_RS07925	COG0442	prolyl-tRNA aminoacylation
DM194_RS07940	COG0519	Catalyzes the synthesis of GMP from XMP
DM194_RS07950	COG0346	lactoylglutathione lyase activity
DM194_RS07970	COG1007	ATP synthesis coupled electron transport
DM194_RS07985	COG0713	ATP synthesis coupled electron transport
DM194_RS08000	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DM194_RS08005	COG1034	ATP synthesis coupled electron transport
DM194_RS08015	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DM194_RS08020	COG0649	NAD binding
DM194_RS08025	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DM194_RS08030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DM194_RS08035	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DM194_RS08115	COG0500	methyltransferase
DM194_RS08120	COG0140	phosphoribosyl-ATP diphosphatase activity
DM194_RS08130	COG2862	Uncharacterized protein family, UPF0114
DM194_RS08150	COG0768	penicillin binding
DM194_RS08155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DM194_RS08165	COG0028	Belongs to the TPP enzyme family
DM194_RS08170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DM194_RS08175	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DM194_RS08190	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DM194_RS08205	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DM194_RS08210	COG0830	nickel cation binding
DM194_RS08215	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DM194_RS08220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DM194_RS08225	COG0804	urea catabolic process
DM194_RS08230	COG0832	Belongs to the urease beta subunit family
DM194_RS08235	COG0831	urea catabolic process
DM194_RS08240	COG0829	nickel cation binding
DM194_RS08245	COG2197	response regulator
DM194_RS08250	COG2197	response regulator
DM194_RS08270	COG0693	protein deglycase activity
DM194_RS08285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DM194_RS08290	COG0717	Belongs to the dCTP deaminase family
DM194_RS08310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DM194_RS08345	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DM194_RS08355	COG0557	exoribonuclease II activity
DM194_RS08360	COG0793	Belongs to the peptidase S41A family
DM194_RS08365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DM194_RS08370	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DM194_RS08385	COG1380	Effector of murein hydrolase LrgA
DM194_RS08390	COG1346	cytolysis
DM194_RS08395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DM194_RS08420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DM194_RS08450	COG0784	Response regulator, receiver
DM194_RS08450	COG4191	Histidine kinase
DM194_RS08480	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DM194_RS08495	COG5554	nitrogen fixation
DM194_RS08505	COG1104	cysteine desulfurase activity
DM194_RS08520	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DM194_RS08540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DM194_RS08550	COG0745	RESPONSE REGULATOR receiver
DM194_RS08555	COG2176	DNA-directed DNA polymerase activity
DM194_RS08555	COG5002	protein histidine kinase activity
DM194_RS08565	COG5002	protein histidine kinase activity
DM194_RS08570	COG4191	Histidine kinase
DM194_RS08575	COG3852	Histidine kinase
DM194_RS08585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DM194_RS08625	COG0752	glycyl-tRNA synthetase alpha subunit
DM194_RS08630	COG0751	glycine-tRNA ligase activity
DM194_RS08635	COG0312	modulator of DNA gyrase
DM194_RS08640	COG0047	phosphoribosylformylglycinamidine synthase activity
DM194_RS08645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DM194_RS08665	COG2198	Histidine kinase
DM194_RS08665	COG0784	Response regulator, receiver
DM194_RS08665	COG2205	protein histidine kinase activity
DM194_RS08690	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DM194_RS08705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DM194_RS08705	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DM194_RS08720	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DM194_RS08730	COG0463	Glycosyl transferase, family 2
DM194_RS08755	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DM194_RS08770	COG3118	belongs to the thioredoxin family
DM194_RS08780	COG2835	tetraacyldisaccharide 4'-kinase activity
DM194_RS08790	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DM194_RS08795	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS08800	COG0183	Belongs to the thiolase family
DM194_RS08805	COG3243	poly(R)-hydroxyalkanoic acid synthase
DM194_RS08810	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
DM194_RS08845	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
DM194_RS08855	COG1132	(ABC) transporter
DM194_RS08860	COG0254	rRNA binding
DM194_RS08870	COG0071	Belongs to the small heat shock protein (HSP20) family
DM194_RS08890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DM194_RS08895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DM194_RS08900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DM194_RS08910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DM194_RS08925	COG0793	Belongs to the peptidase S41A family
DM194_RS08930	COG4942	peptidase
DM194_RS08935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DM194_RS08940	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DM194_RS08945	COG0799	negative regulation of ribosome biogenesis
DM194_RS08950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DM194_RS08965	COG1051	belongs to the nudix hydrolase family
DM194_RS08975	COG0745	RESPONSE REGULATOR receiver
DM194_RS08980	COG0643	Histidine kinase
DM194_RS08980	COG2198	Histidine kinase
DM194_RS08985	COG0835	chemotaxis
DM194_RS08990	COG0840	transmembrane signaling receptor activity
DM194_RS09000	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DM194_RS09005	COG2201	protein-glutamate methylesterase activity
DM194_RS09010	COG0840	transmembrane signaling receptor activity
DM194_RS09015	COG1366	Belongs to the anti-sigma-factor antagonist family
DM194_RS09035	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DM194_RS09040	COG0579	oxidoreductase
DM194_RS09045	COG0071	Belongs to the small heat shock protein (HSP20) family
DM194_RS09075	COG1322	Protein conserved in bacteria
DM194_RS09090	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS09095	COG0436	Aminotransferase
DM194_RS09135	COG1278	Cold shock
DM194_RS09140	COG1902	pentaerythritol trinitrate reductase activity
DM194_RS09150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DM194_RS09170	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DM194_RS09180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DM194_RS09185	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DM194_RS09210	COG1192	Involved in chromosome partitioning
DM194_RS09215	COG0009	L-threonylcarbamoyladenylate synthase
DM194_RS09220	COG0277	FAD linked oxidase domain protein
DM194_RS09225	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DM194_RS09235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DM194_RS09240	COG0747	negative chemotaxis
DM194_RS09255	COG0101	tRNA pseudouridine synthase activity
DM194_RS09260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DM194_RS09265	COG0242	peptide deformylase activity
DM194_RS09270	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DM194_RS09285	COG0513	Belongs to the DEAD box helicase family
DM194_RS09300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DM194_RS09305	COG2084	Dehydrogenase
DM194_RS09315	COG0679	Auxin Efflux Carrier
DM194_RS09325	COG1199	ATP-dependent helicase activity
DM194_RS09325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DM194_RS09330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DM194_RS09340	COG1595	DNA-templated transcription, initiation
DM194_RS09360	COG0784	Response regulator, receiver
DM194_RS09360	COG2205	protein histidine kinase activity
DM194_RS09360	COG5002	protein histidine kinase activity
DM194_RS09375	COG3279	Response regulator of the LytR AlgR family
DM194_RS09395	COG2885	chlorophyll binding
DM194_RS09400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DM194_RS09415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DM194_RS09430	COG2350	Protein conserved in bacteria
DM194_RS09450	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DM194_RS09455	COG2205	protein histidine kinase activity
DM194_RS09465	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DM194_RS09480	COG2885	chlorophyll binding
DM194_RS09490	COG0586	Pfam SNARE associated Golgi protein
DM194_RS09510	COG1278	Cold shock
DM194_RS09565	COG3327	negative regulation of DNA-templated transcription, initiation
DM194_RS09585	COG0840	transmembrane signaling receptor activity
DM194_RS09595	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DM194_RS09610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DM194_RS09625	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DM194_RS09630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DM194_RS09650	COG0167	dihydroorotate dehydrogenase activity
DM194_RS09715	COG2032	superoxide dismutase activity
DM194_RS09720	COG0513	Belongs to the DEAD box helicase family
DM194_RS09725	COG0625	glutathione transferase activity
DM194_RS09745	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DM194_RS09755	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DM194_RS09765	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DM194_RS09785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DM194_RS09795	COG4974	Belongs to the 'phage' integrase family
DM194_RS09805	COG0840	transmembrane signaling receptor activity
DM194_RS09810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DM194_RS09825	COG4191	Histidine kinase
DM194_RS09835	COG4106	trans-aconitate 2-methyltransferase activity
DM194_RS09850	COG0126	phosphoglycerate kinase activity
DM194_RS09865	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DM194_RS09870	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DM194_RS09880	COG0587	DNA-directed DNA polymerase activity
DM194_RS09905	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DM194_RS09915	COG0181	hydroxymethylbilane synthase activity
DM194_RS09945	COG1442	glycosyl transferase family 8
DM194_RS09945	COG1216	Glycosyl transferase, family 2
DM194_RS09955	COG1983	PspC domain protein
DM194_RS09965	COG1842	Phage shock protein A
DM194_RS09970	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DM194_RS09975	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DM194_RS09980	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DM194_RS09985	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DM194_RS09995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DM194_RS10015	COG1058	Belongs to the CinA family
DM194_RS10015	COG1546	Belongs to the CinA family
DM194_RS10020	COG1489	DNA binding
DM194_RS10025	COG0024	Methionine aminopeptidase
DM194_RS10030	COG4221	oxidoreductase activity
DM194_RS10045	COG3158	transport of potassium into the cell
DM194_RS10050	COG0784	Response regulator, receiver
DM194_RS10050	COG3437	response regulator, receiver
DM194_RS10070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DM194_RS10085	COG0825	malonyl-CoA metabolic process
DM194_RS10130	COG2205	protein histidine kinase activity
DM194_RS10130	COG2202	Pas domain
DM194_RS10145	COG0560	Phosphoserine phosphatase
DM194_RS10145	COG3830	Belongs to the UPF0237 family
DM194_RS10155	COG1595	DNA-templated transcription, initiation
DM194_RS10160	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DM194_RS10175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DM194_RS10185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DM194_RS10200	COG1695	Transcriptional regulator
DM194_RS10210	COG0492	ferredoxin-NADP+ reductase activity
DM194_RS10215	COG0601	transmembrane transport
DM194_RS10225	COG0444	Belongs to the ABC transporter superfamily
DM194_RS10230	COG4608	Belongs to the ABC transporter superfamily
DM194_RS10245	COG0583	DNA-binding transcription factor activity
DM194_RS10250	COG0604	alcohol dehydrogenase
DM194_RS10265	COG4566	intracellular signal transduction
DM194_RS10280	COG0459	protein refolding
DM194_RS10285	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DM194_RS10290	COG5425	PFAM Usg family protein
DM194_RS10300	COG3772	lysozyme
DM194_RS10305	COG1612	heme a metabolic process
DM194_RS10310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DM194_RS10320	COG2217	Heavy metal translocating P-type atpase
DM194_RS10345	COG3278	Belongs to the heme-copper respiratory oxidase family
DM194_RS10355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DM194_RS10375	COG1177	transmembrane transport
DM194_RS10395	COG0156	8-amino-7-oxononanoate synthase activity
DM194_RS10400	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DM194_RS10410	COG0135	phosphoribosylanthranilate isomerase activity
DM194_RS10425	COG5265	(ABC) transporter
DM194_RS10430	COG0840	transmembrane signaling receptor activity
DM194_RS10465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DM194_RS10480	COG0861	Integral membrane protein TerC family
DM194_RS10495	COG0583	DNA-binding transcription factor activity
DM194_RS10520	COG0138	bifunctional purine biosynthesis protein purh
DM194_RS10530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DM194_RS10530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DM194_RS10540	COG1024	Enoyl-CoA hydratase
DM194_RS10545	COG0477	Major facilitator Superfamily
DM194_RS10550	COG0583	DNA-binding transcription factor activity
DM194_RS10565	COG1272	protein, Hemolysin III
DM194_RS10590	COG0137	argininosuccinate synthase activity
DM194_RS10600	COG0667	Aldo Keto reductase
DM194_RS10625	COG2423	ornithine cyclodeaminase activity
DM194_RS10635	COG0776	regulation of translation
DM194_RS10650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DM194_RS10685	COG0783	Belongs to the Dps family
DM194_RS10695	COG0840	transmembrane signaling receptor activity
DM194_RS10700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DM194_RS10780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DM194_RS10820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DM194_RS10830	COG0784	Response regulator, receiver
DM194_RS10830	COG3437	response regulator, receiver
DM194_RS10835	COG3813	Protein conserved in bacteria
DM194_RS10840	COG0625	glutathione transferase activity
DM194_RS10845	COG1473	amidohydrolase
DM194_RS10855	COG5001	Diguanylate cyclase
DM194_RS10875	COG4106	trans-aconitate 2-methyltransferase activity
DM194_RS10885	COG1040	competence protein
DM194_RS10895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DM194_RS10915	COG3162	membrane
DM194_RS10945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DM194_RS10955	COG0542	response to heat
DM194_RS10975	COG2890	protein-(glutamine-N5) methyltransferase activity
DM194_RS10985	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DM194_RS10990	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DM194_RS11005	COG2070	2-Nitropropane dioxygenase
DM194_RS11015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DM194_RS11025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM194_RS11030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DM194_RS11035	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DM194_RS11040	COG1137	ATPase activity
DM194_RS11055	COG0517	IMP dehydrogenase activity
DM194_RS11055	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DM194_RS11100	COG0456	acetyltransferase
DM194_RS11110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DM194_RS11115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DM194_RS11120	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DM194_RS11135	COG2205	protein histidine kinase activity
DM194_RS11140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DM194_RS11150	COG1573	uracil-dna glycosylase
DM194_RS11160	COG2154	pterin-4-alpha-carbinolamine dehydratase
DM194_RS11175	COG0501	Belongs to the peptidase M48B family
DM194_RS11200	COG0271	Belongs to the BolA IbaG family
DM194_RS11225	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DM194_RS11240	COG4974	Belongs to the 'phage' integrase family
DM194_RS11250	COG2205	protein histidine kinase activity
DM194_RS11255	COG0784	Response regulator, receiver
DM194_RS11255	COG2205	protein histidine kinase activity
DM194_RS11255	COG5002	protein histidine kinase activity
DM194_RS11265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DM194_RS11270	COG2204	response regulator
DM194_RS11275	COG1278	Cold shock
DM194_RS11280	COG2205	protein histidine kinase activity
DM194_RS11280	COG0784	Response regulator, receiver
DM194_RS11285	COG0133	tryptophan synthase activity
DM194_RS11295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DM194_RS11300	COG0285	dihydrofolate synthase activity
DM194_RS11320	COG1872	DUF167
DM194_RS11325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DM194_RS11330	COG0598	Magnesium transport protein CorA
DM194_RS11345	COG0039	L-malate dehydrogenase activity
DM194_RS11350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DM194_RS11355	COG4166	transmembrane transport
DM194_RS11360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DM194_RS11365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM194_RS11370	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM194_RS11370	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DM194_RS11375	COG1660	Displays ATPase and GTPase activities
DM194_RS11390	COG0642	Histidine kinase
DM194_RS11395	COG0745	RESPONSE REGULATOR receiver
DM194_RS11405	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DM194_RS11490	COG4957	zinc ion binding
DM194_RS11510	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DM194_RS11535	COG0443	Heat shock 70 kDa protein
DM194_RS11545	COG3706	GGDEF domain
DM194_RS11550	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DM194_RS11555	COG0667	Aldo Keto reductase
DM194_RS11570	COG4181	ATPase activity
DM194_RS11580	COG0670	Belongs to the BI1 family
DM194_RS11590	COG0745	RESPONSE REGULATOR receiver
DM194_RS11595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DM194_RS11605	COG0573	inorganic phosphate transmembrane transporter activity
DM194_RS11610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DM194_RS11630	COG0281	malic enzyme
DM194_RS11630	COG0280	phosphate acetyltransferase
DM194_RS11635	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DM194_RS11640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DM194_RS11645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DM194_RS11650	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DM194_RS11665	COG0357	Ribosomal RNA small subunit methyltransferase G
DM194_RS11670	COG0445	tRNA wobble uridine modification
DM194_RS11690	COG1331	Highly conserved protein containing a thioredoxin domain
DM194_RS11705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DM194_RS11745	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DM194_RS11760	COG4395	Tim44
DM194_RS11765	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DM194_RS11770	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DM194_RS11830	COG4235	cytochrome complex assembly
DM194_RS11835	COG3088	subunit of a heme lyase
DM194_RS11840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DM194_RS11845	COG1138	Cytochrome C-type biogenesis protein
DM194_RS11850	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DM194_RS11860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DM194_RS11880	COG1185	polyribonucleotide nucleotidyltransferase activity
DM194_RS11885	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DM194_RS11890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DM194_RS11915	COG0779	Required for maturation of 30S ribosomal subunits
DM194_RS11920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DM194_RS11925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DM194_RS11930	COG1396	sequence-specific DNA binding
DM194_RS11935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DM194_RS11940	COG1253	flavin adenine dinucleotide binding
DM194_RS11950	COG1702	phosphate starvation-inducible protein PhoH
DM194_RS11955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DM194_RS11965	COG2967	ApaG domain
DM194_RS11970	COG0302	gtp cyclohydrolase
DM194_RS11975	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DM194_RS11985	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DM194_RS11990	COG0668	transmembrane transport
DM194_RS12005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DM194_RS12020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DM194_RS12035	COG0730	response to heat
DM194_RS12050	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DM194_RS12080	COG0606	chelatase, subunit chli
DM194_RS12095	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DM194_RS12100	COG0180	Tryptophanyl-tRNA synthetase
DM194_RS12115	COG0792	nuclease activity
DM194_RS12120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DM194_RS12160	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DM194_RS12165	COG0386	Belongs to the glutathione peroxidase family
DM194_RS12180	COG0739	heme binding
DM194_RS12220	COG3436	PFAM IS66 Orf2 family protein
DM194_RS12225	COG4372	Transposase
DM194_RS12250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DM194_RS12305	COG1518	maintenance of DNA repeat elements
DM194_RS12310	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DM194_RS12320	COG0038	chloride channel
DM194_RS12340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DM194_RS12375	COG2887	Belongs to the helicase family. UvrD subfamily
DM194_RS12380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DM194_RS12390	COG0802	atpase or kinase
DM194_RS12405	COG0747	negative chemotaxis
DM194_RS12415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DM194_RS12425	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DM194_RS12445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DM194_RS12455	COG1024	Enoyl-CoA hydratase
DM194_RS12460	COG0268	Binds directly to 16S ribosomal RNA
DM194_RS12465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DM194_RS12475	COG0745	RESPONSE REGULATOR receiver
DM194_RS12490	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DM194_RS12500	COG3842	ATPase activity
DM194_RS12505	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DM194_RS12510	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DM194_RS12530	COG2264	protein methyltransferase activity
DM194_RS12550	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DM194_RS12625	COG1234	tRNA 3'-trailer cleavage
DM194_RS12635	COG0745	RESPONSE REGULATOR receiver
DM194_RS12685	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DM194_RS12690	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DM194_RS12695	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DM194_RS12700	COG0295	cytidine deaminase activity
DM194_RS12715	COG3411	Ferredoxin
DM194_RS12720	COG0697	spore germination
DM194_RS12775	COG0583	DNA-binding transcription factor activity
DM194_RS12820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM194_RS12830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DM194_RS12850	COG0740	serine-type endopeptidase activity
DM194_RS12855	COG0463	Glycosyl transferase, family 2
DM194_RS12870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM194_RS12885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DM194_RS12905	COG0308	aminopeptidase N
DM194_RS12945	COG3436	PFAM IS66 Orf2 family protein
DM194_RS12950	COG4372	Transposase
DM194_RS12970	COG1358	cellular component organization or biogenesis
DM194_RS13015	COG4245	von Willebrand factor, type A
DM194_RS13025	COG4245	von Willebrand factor, type A
DM194_RS13115	COG0316	Belongs to the HesB IscA family
DM194_RS13120	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DM194_RS13135	COG1472	Belongs to the glycosyl hydrolase 3 family
DM194_RS13140	COG1994	Peptidase M50
DM194_RS13145	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DM194_RS13150	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DM194_RS13155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DM194_RS13160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DM194_RS13165	COG0805	protein transport
DM194_RS13170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DM194_RS13195	COG0420	3'-5' exonuclease activity
DM194_RS13225	COG0471	metal ion transport
DM194_RS13225	COG3273	potassium ion transport
DM194_RS13230	COG0517	IMP dehydrogenase activity
DM194_RS13245	COG2205	protein histidine kinase activity
DM194_RS13245	COG0784	Response regulator, receiver
DM194_RS13250	COG1758	RNA polymerase activity
DM194_RS13280	COG4191	Histidine kinase
DM194_RS13285	COG1301	dicarboxylic acid transport
DM194_RS13290	COG5507	3-demethylubiquinone-9 3-methyltransferase
DM194_RS13295	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DM194_RS13305	COG2258	MOSC domain
DM194_RS13315	COG2183	response to ionizing radiation
DM194_RS13345	COG0393	Putative heavy-metal-binding
DM194_RS13350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DM194_RS13370	COG1309	transcriptional regulator
DM194_RS13375	COG3706	GGDEF domain
DM194_RS13380	COG0772	Belongs to the SEDS family
DM194_RS13385	COG2273	Hydrolase Family 16
DM194_RS13395	COG1172	Belongs to the binding-protein-dependent transport system permease family
DM194_RS13425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DM194_RS13430	COG4520	surface antigen
DM194_RS13455	COG0281	malic enzyme
DM194_RS13455	COG0280	phosphate acetyltransferase
DM194_RS13460	COG1301	dicarboxylic acid transport
DM194_RS13465	COG4191	Histidine kinase
DM194_RS13470	COG2204	response regulator
DM194_RS13490	COG1640	4-alpha-glucanotransferase
DM194_RS13515	COG1024	Enoyl-CoA hydratase
DM194_RS13525	COG0625	glutathione transferase activity
DM194_RS13545	COG0737	Belongs to the 5'-nucleotidase family
DM194_RS13565	COG1749	Flagellar hook protein flgE
DM194_RS13565	COG1749	Flagellar hook protein flgE
DM194_RS13580	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DM194_RS13585	COG0366	Alpha amylase catalytic
DM194_RS13620	COG2226	methyltransferase
DM194_RS13625	COG0859	PFAM glycosyl transferase family 9
DM194_RS13625	COG0457	Tetratricopeptide repeat
DM194_RS13640	COG0859	PFAM glycosyl transferase family 9
DM194_RS13640	COG0457	Tetratricopeptide repeat
DM194_RS13655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DM194_RS13660	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS13685	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DM194_RS13690	COG2089	acid synthase
DM194_RS13710	COG2205	protein histidine kinase activity
DM194_RS13710	COG2198	Histidine kinase
DM194_RS13710	COG0784	Response regulator, receiver
DM194_RS13725	COG0588	phosphoglycerate mutase activity
DM194_RS13730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DM194_RS13755	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DM194_RS13760	COG1045	serine acetyltransferase
DM194_RS13780	COG1215	transferase activity, transferring glycosyl groups
DM194_RS13785	COG0438	transferase activity, transferring glycosyl groups
DM194_RS13805	COG0318	PFAM AMP-dependent synthetase and ligase
DM194_RS13810	COG0367	asparagine synthase
DM194_RS13815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DM194_RS13840	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DM194_RS13845	COG4208	sulfate ABC transporter
DM194_RS13855	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DM194_RS13865	COG0784	Response regulator, receiver
DM194_RS13865	COG4191	Histidine kinase
DM194_RS13875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DM194_RS13880	COG5001	Diguanylate cyclase
DM194_RS13915	COG1309	transcriptional regulator
DM194_RS13930	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM194_RS13940	COG0318	PFAM AMP-dependent synthetase and ligase
DM194_RS13945	COG1024	Enoyl-CoA hydratase
DM194_RS13945	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM194_RS13950	COG1960	acyl-CoA dehydrogenase activity
DM194_RS13960	COG2203	Gaf domain
DM194_RS13960	COG2200	EAL domain
DM194_RS13960	COG2199	diguanylate cyclase activity
DM194_RS13990	COG2233	PERMEase
DM194_RS14000	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS14005	COG3246	L-lysine catabolic process to acetate
DM194_RS14010	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM194_RS14015	COG2204	response regulator
DM194_RS14020	COG2080	2 iron, 2 sulfur cluster binding
DM194_RS14025	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DM194_RS14030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DM194_RS14040	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DM194_RS14050	COG2354	Protein conserved in bacteria
DM194_RS14055	COG1115	amino acid carrier protein
DM194_RS14080	COG2226	methyltransferase
DM194_RS14095	COG0367	asparagine synthase
DM194_RS14100	COG0489	protein tyrosine kinase activity
DM194_RS14105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DM194_RS14115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DM194_RS14140	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DM194_RS14145	COG1088	dTDP-glucose 4,6-dehydratase activity
DM194_RS14215	COG0252	asparaginase activity
DM194_RS14220	COG2146	nitrite reductase [NAD(P)H] activity
DM194_RS14260	COG3485	protocatechuate 3,4-dioxygenase
DM194_RS14265	COG4948	Mandelate Racemase Muconate Lactonizing
DM194_RS14270	COG0583	DNA-binding transcription factor activity
DM194_RS14280	COG1802	Transcriptional regulator
DM194_RS14285	COG0596	Alpha beta hydrolase
DM194_RS14295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DM194_RS14300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DM194_RS14310	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DM194_RS14315	COG2864	formate dehydrogenase
DM194_RS14320	COG0437	4 iron, 4 sulfur cluster binding
DM194_RS14325	COG0243	molybdopterin cofactor binding
DM194_RS14325	COG3383	formate dehydrogenase (NAD+) activity
DM194_RS14335	COG3852	Histidine kinase
DM194_RS14340	COG2204	response regulator
DM194_RS14350	COG1120	ATPase activity
DM194_RS14355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM194_RS14385	COG3547	Transposase (IS116 IS110 IS902 family)
DM194_RS14455	COG1522	sequence-specific DNA binding
DM194_RS14465	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DM194_RS14465	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DM194_RS14480	COG0564	pseudouridine synthase activity
DM194_RS14485	COG0784	Response regulator, receiver
DM194_RS14485	COG2205	protein histidine kinase activity
DM194_RS14490	COG1741	Belongs to the pirin family
DM194_RS14495	COG3768	UPF0283 membrane protein
DM194_RS14500	COG3106	COG3106 Predicted ATPase
DM194_RS14510	COG4770	biotin carboxylase activity
DM194_RS14515	COG1024	Enoyl-CoA hydratase
DM194_RS14520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DM194_RS14525	COG1960	acyl-CoA dehydrogenase activity
DM194_RS14530	COG0183	Belongs to the thiolase family
DM194_RS14535	COG1960	acyl-CoA dehydrogenase activity
DM194_RS14560	COG2205	protein histidine kinase activity
DM194_RS14615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DM194_RS14665	COG0596	Alpha beta hydrolase
DM194_RS14685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DM194_RS14755	COG3436	PFAM IS66 Orf2 family protein
DM194_RS14760	COG4372	Transposase
DM194_RS14820	COG0587	DNA-directed DNA polymerase activity
DM194_RS14830	COG0586	Pfam SNARE associated Golgi protein
DM194_RS14835	COG0501	Belongs to the peptidase M48B family
DM194_RS14840	COG3685	Protein conserved in bacteria
DM194_RS14845	COG0667	Aldo Keto reductase
DM194_RS14850	COG0583	DNA-binding transcription factor activity
DM194_RS14860	COG1132	(ABC) transporter
DM194_RS14905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DM194_RS14920	COG0583	DNA-binding transcription factor activity
DM194_RS14925	COG1942	4-Oxalocrotonate Tautomerase
DM194_RS14960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DM194_RS14980	COG2003	Belongs to the UPF0758 family
DM194_RS14985	COG1396	sequence-specific DNA binding
DM194_RS15000	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DM194_RS15125	COG0675	Transposase, IS605 OrfB family
DM194_RS15155	COG1396	sequence-specific DNA binding
DM194_RS15185	COG0675	Transposase, IS605 OrfB family
DM194_RS15280	COG1640	4-alpha-glucanotransferase
DM194_RS15295	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DM194_RS15300	COG0366	Alpha amylase catalytic
DM194_RS15315	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DM194_RS15315	COG2885	chlorophyll binding
DM194_RS15320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DM194_RS15325	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DM194_RS15330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DM194_RS15335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DM194_RS15355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DM194_RS15360	COG0583	DNA-binding transcription factor activity
DM194_RS15365	COG0625	glutathione transferase activity
DM194_RS15390	COG0411	ABC transporter
DM194_RS15420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DM194_RS15425	COG3383	formate dehydrogenase (NAD+) activity
DM194_RS15440	COG0583	DNA-binding transcription factor activity
DM194_RS15470	COG0784	Response regulator, receiver
DM194_RS15470	COG5002	protein histidine kinase activity
DM194_RS15470	COG2205	protein histidine kinase activity
DM194_RS15480	COG0747	negative chemotaxis
DM194_RS15485	COG1475	DNA binding
DM194_RS15490	COG1192	Involved in chromosome partitioning
DM194_RS15515	COG2902	Dehydrogenase
DM194_RS15520	COG0469	pyruvate kinase activity
DM194_RS15540	COG2205	protein histidine kinase activity
DM194_RS15550	COG1309	transcriptional regulator
DM194_RS15555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DM194_RS15590	COG0318	PFAM AMP-dependent synthetase and ligase
DM194_RS15625	COG2080	2 iron, 2 sulfur cluster binding
DM194_RS15630	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DM194_RS15635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DM194_RS15640	COG0583	DNA-binding transcription factor activity
DM194_RS15645	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS15650	COG3959	Transketolase, thiamine diphosphate binding domain
DM194_RS15655	COG3958	Transketolase
DM194_RS15660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DM194_RS15665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DM194_RS15670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DM194_RS15675	COG2084	Dehydrogenase
DM194_RS15685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DM194_RS15695	COG1335	isochorismatase
DM194_RS15740	COG2188	Transcriptional regulator
DM194_RS15750	COG0488	(ABC) transporter
DM194_RS15775	COG3064	Membrane
DM194_RS15775	COG4991	sh3 domain protein
DM194_RS15775	COG0515	serine threonine protein kinase
DM194_RS15785	COG3243	poly(R)-hydroxyalkanoic acid synthase
DM194_RS15795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM194_RS15805	COG0678	peroxiredoxin activity
DM194_RS15820	COG0148	phosphopyruvate hydratase activity
DM194_RS15825	COG0596	Alpha beta hydrolase
DM194_RS15830	COG0728	peptidoglycan biosynthetic process
DM194_RS15840	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DM194_RS15855	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DM194_RS15890	COG4974	Belongs to the 'phage' integrase family
DM194_RS15895	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DM194_RS15905	COG0352	thiamine-phosphate diphosphorylase activity
DM194_RS15910	COG1802	Transcriptional regulator
DM194_RS15915	COG0469	pyruvate kinase activity
DM194_RS15925	COG2084	Dehydrogenase
DM194_RS15930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DM194_RS15930	COG0574	Belongs to the PEP-utilizing enzyme family
DM194_RS15940	COG0517	IMP dehydrogenase activity
DM194_RS15965	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DM194_RS15970	COG0517	IMP dehydrogenase activity
DM194_RS16000	COG2351	hydroxyisourate hydrolase activity
DM194_RS16005	COG3960	tartronate-semialdehyde synthase activity
DM194_RS16020	COG1414	Transcriptional regulator
DM194_RS16025	COG1802	Transcriptional regulator
DM194_RS16030	COG0028	Belongs to the TPP enzyme family
DM194_RS16035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DM194_RS16040	COG0045	succinate-CoA ligase (ADP-forming) activity
DM194_RS16050	COG1414	Transcriptional regulator
DM194_RS16055	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS16055	COG0604	alcohol dehydrogenase
DM194_RS16055	COG3321	synthase
DM194_RS16085	COG0784	Response regulator, receiver
DM194_RS16105	COG0697	spore germination
DM194_RS16110	COG0747	negative chemotaxis
DM194_RS16115	COG0601	transmembrane transport
DM194_RS16120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DM194_RS16125	COG0444	Belongs to the ABC transporter superfamily
DM194_RS16130	COG4608	Belongs to the ABC transporter superfamily
DM194_RS16135	COG1666	GTP binding
DM194_RS16150	COG2890	protein-(glutamine-N5) methyltransferase activity
DM194_RS16160	COG0142	geranyltranstransferase activity
DM194_RS16190	COG2860	membrane
DM194_RS16200	COG2217	Heavy metal translocating P-type atpase
DM194_RS16220	COG2814	Major facilitator Superfamily
DM194_RS16240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DM194_RS16250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DM194_RS16255	COG0402	S-adenosylhomocysteine deaminase activity
DM194_RS16265	COG4603	Belongs to the binding-protein-dependent transport system permease family
DM194_RS16285	COG1414	Transcriptional regulator
DM194_RS16290	COG3842	ATPase activity
DM194_RS16295	COG1176	ABC-type spermidine putrescine transport system, permease component I
DM194_RS16300	COG1177	transmembrane transport
DM194_RS16330	COG2133	pyrroloquinoline quinone binding
DM194_RS16340	COG0459	protein refolding
DM194_RS16345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DM194_RS16350	COG1063	alcohol dehydrogenase
DM194_RS16355	COG0673	inositol 2-dehydrogenase activity
DM194_RS16360	COG1609	Transcriptional regulator
DM194_RS16365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DM194_RS16425	COG3436	PFAM IS66 Orf2 family protein
DM194_RS16430	COG4372	Transposase
DM194_RS16475	COG0582	viral genome integration into host DNA
DM194_RS16480	COG4396	Host-nuclease inhibitor protein Gam
DM194_RS16485	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DM194_RS16640	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DM194_RS16645	COG2223	nitrite transmembrane transporter activity
DM194_RS16650	COG3546	catalase activity
DM194_RS16670	COG4176	ABC-type proline glycine betaine transport system permease component
DM194_RS16675	COG1309	transcriptional regulator
DM194_RS16685	COG2068	MobA-Related Protein
DM194_RS16695	COG0737	Belongs to the 5'-nucleotidase family
DM194_RS16720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DM194_RS16730	COG0784	Response regulator, receiver
DM194_RS16730	COG3437	response regulator, receiver
DM194_RS16735	COG0747	negative chemotaxis
DM194_RS16745	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DM194_RS16780	COG2358	TRAP transporter, solute receptor (TAXI family
DM194_RS16800	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DM194_RS16820	COG3012	SEC-C Motif Domain Protein
DM194_RS16830	COG1448	Aminotransferase
DM194_RS16835	COG0521	Mo-molybdopterin cofactor biosynthetic process
DM194_RS16840	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DM194_RS16855	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS16860	COG1755	Isoprenylcysteine carboxyl methyltransferase
DM194_RS16875	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DM194_RS16885	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
DM194_RS16895	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
DM194_RS16905	COG2204	response regulator
DM194_RS16910	COG0375	protein maturation
DM194_RS16965	COG1289	transmembrane transporter activity
DM194_RS16980	COG3956	TIGRFAM MazG family protein
DM194_RS17015	COG0183	Belongs to the thiolase family
DM194_RS17020	COG1024	Enoyl-CoA hydratase
DM194_RS17030	COG1595	DNA-templated transcription, initiation
DM194_RS17035	COG3806	Anti-sigma factor
DM194_RS17045	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS17080	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
DM194_RS17085	COG0702	epimerase
DM194_RS17100	COG1229	Formylmethanofuran dehydrogenase subunit A
DM194_RS17105	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
DM194_RS17130	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
DM194_RS17145	COG0189	ligase activity
DM194_RS17155	COG1131	(ABC) transporter
DM194_RS17215	COG3383	formate dehydrogenase (NAD+) activity
DM194_RS17265	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DM194_RS17280	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DM194_RS17285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DM194_RS17290	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS17295	COG1959	2 iron, 2 sulfur cluster binding
DM194_RS17300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DM194_RS17305	COG1475	DNA binding
DM194_RS17350	COG0719	Fe-S assembly protein
DM194_RS17355	COG0396	ATPase activity
DM194_RS17360	COG0719	Fe-S assembly protein
DM194_RS17365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DM194_RS17370	COG0822	iron-sulfur transferase activity
DM194_RS17375	COG2151	metal-sulfur cluster biosynthetic enzyme
DM194_RS17380	COG0316	Belongs to the HesB IscA family
DM194_RS17390	COG1741	Belongs to the pirin family
DM194_RS17410	COG1414	Transcriptional regulator
DM194_RS17420	COG0800	Aldolase
DM194_RS17440	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS17445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DM194_RS17450	COG1942	4-Oxalocrotonate Tautomerase
DM194_RS17455	COG0583	DNA-binding transcription factor activity
DM194_RS17465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DM194_RS17475	COG1737	Transcriptional regulator
DM194_RS17475	COG0837	glucose binding
DM194_RS17480	COG1882	Formate acetyltransferase
DM194_RS17485	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DM194_RS17495	COG1609	Transcriptional regulator
DM194_RS17500	COG1013	pyruvate-flavodoxin oxidoreductase activity
DM194_RS17500	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DM194_RS17500	COG0674	pyruvate-flavodoxin oxidoreductase activity
DM194_RS17505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DM194_RS17525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM194_RS17550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DM194_RS17550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DM194_RS17580	COG5002	protein histidine kinase activity
DM194_RS17605	COG1177	transmembrane transport
DM194_RS17610	COG1176	ABC-type spermidine putrescine transport system, permease component I
DM194_RS17615	COG3842	ATPase activity
DM194_RS17625	COG2076	Multidrug Resistance protein
DM194_RS17630	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DM194_RS17630	COG0546	phosphoglycolate phosphatase activity
DM194_RS17635	COG0174	glutamine synthetase
DM194_RS17640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM194_RS17650	COG1196	nuclear chromosome segregation
DM194_RS17665	COG1194	a g-specific adenine glycosylase
DM194_RS17685	COG3047	cAMP biosynthetic process
DM194_RS17690	COG0517	IMP dehydrogenase activity
DM194_RS17690	COG0516	GMP reductase activity
DM194_RS17695	COG2197	response regulator
DM194_RS17700	COG1960	acyl-CoA dehydrogenase activity
DM194_RS17705	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM194_RS17705	COG1024	Enoyl-CoA hydratase
DM194_RS17710	COG0183	Belongs to the thiolase family
DM194_RS17725	COG2373	Large extracellular alpha-helical protein
DM194_RS17745	COG3273	potassium ion transport
DM194_RS17745	COG0471	metal ion transport
DM194_RS17775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DM194_RS17780	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DM194_RS17785	COG1012	belongs to the aldehyde dehydrogenase family
DM194_RS17790	COG1396	sequence-specific DNA binding
DM194_RS17790	COG1917	Cupin 2, conserved barrel domain protein
DM194_RS17800	COG1176	ABC-type spermidine putrescine transport system, permease component I
DM194_RS17805	COG2182	Extracellular solute-binding protein
DM194_RS17810	COG3842	ATPase activity
DM194_RS17815	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DM194_RS17835	COG0583	DNA-binding transcription factor activity
DM194_RS17855	COG0583	DNA-binding transcription factor activity
DM194_RS17860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DM194_RS17865	COG0235	Class ii aldolase
DM194_RS17875	COG0601	transmembrane transport
DM194_RS17890	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DM194_RS17915	COG2723	6-phospho-beta-galactosidase activity
DM194_RS17930	COG3436	PFAM IS66 Orf2 family protein
DM194_RS17935	COG4372	Transposase
DM194_RS17970	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DM194_RS17980	COG1215	transferase activity, transferring glycosyl groups
DM194_RS18000	COG5002	protein histidine kinase activity
DM194_RS18025	COG0795	lipopolysaccharide-transporting ATPase activity
DM194_RS18050	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DM194_RS18060	COG1192	Involved in chromosome partitioning
DM194_RS18090	COG2986	histidine ammonia-lyase
DM194_RS18095	COG0402	S-adenosylhomocysteine deaminase activity
DM194_RS18100	COG1228	amidohydrolase
DM194_RS18105	COG2188	Transcriptional regulator
DM194_RS18130	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS18140	COG0542	response to heat
DM194_RS18185	COG1360	Flagellar Motor Protein
DM194_RS18200	COG3501	Rhs element vgr protein
DM194_RS18240	COG0583	DNA-binding transcription factor activity
DM194_RS18245	COG0655	NAD(P)H dehydrogenase (quinone) activity
DM194_RS18250	COG0435	Glutathione S-transferase
DM194_RS18285	COG0408	coproporphyrinogen oxidase activity
DM194_RS18290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DM194_RS18325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DM194_RS18330	COG4770	biotin carboxylase activity
DM194_RS18335	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DM194_RS18335	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DM194_RS18350	COG1271	oxidase subunit
DM194_RS18355	COG1294	oxidase, subunit
DM194_RS18365	COG2080	2 iron, 2 sulfur cluster binding
DM194_RS18370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DM194_RS18380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DM194_RS18385	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DM194_RS18390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DM194_RS18400	COG0356	it plays a direct role in the translocation of protons across the membrane
DM194_RS18420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DM194_RS18430	COG1012	belongs to the aldehyde dehydrogenase family
DM194_RS18435	COG0028	Belongs to the TPP enzyme family
DM194_RS18445	COG0697	spore germination
DM194_RS18460	COG0438	transferase activity, transferring glycosyl groups
DM194_RS18475	COG0297	glycogen (starch) synthase activity
DM194_RS18495	COG3206	protein involved in exopolysaccharide biosynthesis
DM194_RS18495	COG0489	protein tyrosine kinase activity
DM194_RS18515	COG1609	Transcriptional regulator
DM194_RS18520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM194_RS18520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DM194_RS18525	COG1105	Belongs to the carbohydrate kinase PfkB family
DM194_RS18530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DM194_RS18530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DM194_RS18540	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM194_RS18540	COG1024	Enoyl-CoA hydratase
DM194_RS18545	COG1174	glycine betaine transport
DM194_RS18550	COG1125	glycine betaine transport
DM194_RS18555	COG1174	glycine betaine transport
DM194_RS18560	COG1732	Glycine betaine
DM194_RS18570	COG0535	radical SAM domain protein
DM194_RS18575	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DM194_RS18605	COG1737	Transcriptional regulator
DM194_RS18615	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DM194_RS18665	COG4372	Transposase
DM194_RS18670	COG3436	PFAM IS66 Orf2 family protein
DM194_RS18685	COG4191	Histidine kinase
DM194_RS18690	COG2204	response regulator
DM194_RS18695	COG1840	ABC-type Fe3 transport system, periplasmic component
DM194_RS18705	COG3842	ATPase activity
DM194_RS18710	COG0546	phosphoglycolate phosphatase activity
DM194_RS18725	COG0402	S-adenosylhomocysteine deaminase activity
DM194_RS18740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DM194_RS18765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DM194_RS18770	COG1802	Transcriptional regulator
DM194_RS18780	COG1902	pentaerythritol trinitrate reductase activity
DM194_RS18780	COG0446	pyridine nucleotide-disulphide oxidoreductase
DM194_RS18785	COG1233	COG1233 Phytoene dehydrogenase and related
DM194_RS18790	COG0583	DNA-binding transcription factor activity
DM194_RS18800	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS18865	COG0243	molybdopterin cofactor binding
DM194_RS18870	COG1879	ABC-type sugar transport system periplasmic component
DM194_RS18880	COG0784	Response regulator, receiver
DM194_RS18880	COG2198	Histidine kinase
DM194_RS18880	COG2205	protein histidine kinase activity
DM194_RS18890	COG1124	(ABC) transporter
DM194_RS18900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DM194_RS18960	COG1116	anion transmembrane transporter activity
DM194_RS18965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM194_RS18980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DM194_RS18985	COG4521	taurine ABC transporter
DM194_RS18995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM194_RS19005	COG4221	oxidoreductase activity
DM194_RS19010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DM194_RS19015	COG1321	iron dependent repressor
DM194_RS19020	COG0803	Belongs to the bacterial solute-binding protein 9 family
DM194_RS19025	COG1121	(ABC) transporter
DM194_RS19030	COG1321	iron dependent repressor
DM194_RS19030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DM194_RS19035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DM194_RS19045	COG0243	molybdopterin cofactor binding
DM194_RS19055	COG2201	protein-glutamate methylesterase activity
DM194_RS19075	COG2197	response regulator
DM194_RS19090	COG1794	racemase activity, acting on amino acids and derivatives
DM194_RS19100	COG0366	Alpha amylase catalytic
DM194_RS19115	COG1131	(ABC) transporter
DM194_RS19130	COG5002	protein histidine kinase activity
DM194_RS19130	COG5001	Diguanylate cyclase
DM194_RS19160	COG0154	amidase activity
DM194_RS19175	COG2363	Small membrane protein
DM194_RS19195	COG0123	including yeast histone deacetylase and acetoin utilization protein
DM194_RS19210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DM194_RS19220	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DM194_RS19230	COG1968	undecaprenyl-diphosphatase activity
DM194_RS19240	COG1914	H( )-stimulated, divalent metal cation uptake system
DM194_RS19255	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DM194_RS19270	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DM194_RS19275	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DM194_RS19285	COG5002	protein histidine kinase activity
DM194_RS19285	COG0784	Response regulator, receiver
DM194_RS19315	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DM194_RS19325	COG0183	Belongs to the thiolase family
DM194_RS19330	COG0318	PFAM AMP-dependent synthetase and ligase
DM194_RS19335	COG1268	BioY protein
DM194_RS19345	COG1122	ATPase activity
DM194_RS19350	COG2226	methyltransferase
DM194_RS19355	COG1126	abc transporter atp-binding protein
DM194_RS19365	COG0765	amino acid transport
DM194_RS19375	COG2188	Transcriptional regulator
DM194_RS19380	COG2995	paraquat-inducible protein a
DM194_RS19385	COG3008	intermembrane lipid transfer
DM194_RS19400	COG0583	DNA-binding transcription factor activity
DM194_RS19405	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DM194_RS19410	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DM194_RS19445	COG3180	Ammonia monooxygenase
DM194_RS19460	COG1082	Xylose isomerase domain protein TIM barrel
DM194_RS19470	COG0318	PFAM AMP-dependent synthetase and ligase
DM194_RS19475	COG4264	IucA IucC family
DM194_RS19500	COG1595	DNA-templated transcription, initiation
DM194_RS19505	COG0673	inositol 2-dehydrogenase activity
DM194_RS19515	COG1879	ABC-type sugar transport system periplasmic component
DM194_RS19520	COG1172	Belongs to the binding-protein-dependent transport system permease family
DM194_RS19525	COG1129	ABC transporter
DM194_RS19530	COG1940	carbohydrate kinase activity
DM194_RS19535	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM194_RS19535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DM194_RS19545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DM194_RS19550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DM194_RS19565	COG3842	ATPase activity
DM194_RS19575	COG1176	ABC-type spermidine putrescine transport system, permease component I
DM194_RS19580	COG0581	inorganic phosphate transmembrane transporter activity
DM194_RS19595	COG0154	amidase activity
DM194_RS19605	COG1522	sequence-specific DNA binding
DM194_RS19610	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DM194_RS19615	COG3622	Belongs to the hyi family
DM194_RS19620	COG1914	H( )-stimulated, divalent metal cation uptake system
DM194_RS19630	COG2267	carboxylic ester hydrolase activity
DM194_RS19645	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DM194_RS19660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DM194_RS19665	COG4221	oxidoreductase activity
DM194_RS19675	COG2226	methyltransferase
DM194_RS19715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DM194_RS19745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DM194_RS19750	COG0318	PFAM AMP-dependent synthetase and ligase
DM194_RS19765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DM194_RS19770	COG0348	domain, Protein
DM194_RS19805	COG3290	protein histidine kinase activity
DM194_RS19805	COG0840	transmembrane signaling receptor activity
DM194_RS19815	COG1132	(ABC) transporter
DM194_RS19820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM194_RS19830	COG1120	ATPase activity
DM194_RS19835	COG4774	siderophore transport
DM194_RS19860	COG0277	FAD linked oxidase domain protein
DM194_RS19895	COG0066	3-isopropylmalate dehydratase activity
DM194_RS19900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DM194_RS19915	COG1414	Transcriptional regulator
DM194_RS19925	COG0318	PFAM AMP-dependent synthetase and ligase
DM194_RS19940	COG3128	pkhd-type hydroxylase
DM194_RS19945	COG4774	siderophore transport
DM194_RS19960	COG4607	ABC-type enterochelin transport system periplasmic component
DM194_RS19965	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM194_RS19970	COG4605	iron ion homeostasis
DM194_RS19975	COG4604	ABC transporter, ATP-binding protein
DM194_RS20015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DM194_RS20025	COG2116	formate transmembrane transporter activity
DM194_RS20030	COG1131	(ABC) transporter
DM194_RS20035	COG0842	Transport permease protein
DM194_RS20040	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DM194_RS20050	COG0318	PFAM AMP-dependent synthetase and ligase
DM194_RS20055	COG4191	Histidine kinase
DM194_RS20065	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DM194_RS20075	COG2271	Major facilitator Superfamily
DM194_RS20080	COG1335	isochorismatase
DM194_RS20085	COG3473	Maleate cis-trans isomerase
DM194_RS20090	COG0596	Alpha beta hydrolase
DM194_RS20095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DM194_RS20100	COG2309	aminopeptidase activity
DM194_RS20105	COG1846	Transcriptional regulator
DM194_RS20110	COG2080	2 iron, 2 sulfur cluster binding
DM194_RS20115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DM194_RS20115	COG2010	Cytochrome c
DM194_RS20120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DM194_RS20125	COG0697	spore germination
DM194_RS20130	COG4251	negative regulation of phosphorylation
DM194_RS20135	COG0784	Response regulator, receiver
DM194_RS20140	COG2202	Pas domain
DM194_RS20140	COG3920	Histidine kinase
DM194_RS20145	COG0784	Response regulator, receiver
DM194_RS20150	COG2847	Copper chaperone PCu(A)C
DM194_RS20215	COG1131	(ABC) transporter
DM194_RS20225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DM194_RS20225	COG2169	Transcriptional regulator
DM194_RS20230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DM194_RS20260	COG2226	methyltransferase
DM194_RS20275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM194_RS20285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DM194_RS20290	COG1846	Transcriptional regulator
DM194_RS20300	COG3707	response regulator
DM194_RS20325	COG2030	dehydratase
DM194_RS20325	COG1012	belongs to the aldehyde dehydrogenase family
DM194_RS20335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DM194_RS20345	COG0840	transmembrane signaling receptor activity
DM194_RS20360	COG2201	protein-glutamate methylesterase activity
DM194_RS20365	COG0745	RESPONSE REGULATOR receiver
DM194_RS20370	COG0784	Response regulator, receiver
DM194_RS20370	COG5002	protein histidine kinase activity
DM194_RS20380	COG1363	Peptidase, m42
DM194_RS20385	COG1181	Belongs to the D-alanine--D-alanine ligase family
DM194_RS20385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DM194_RS20390	COG0367	asparagine synthase
DM194_RS20395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DM194_RS20405	COG0028	Belongs to the TPP enzyme family
DM194_RS20415	COG3791	Glutathione-dependent formaldehyde-activating
DM194_RS20420	COG2080	2 iron, 2 sulfur cluster binding
DM194_RS20425	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DM194_RS20430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DM194_RS20440	COG5002	protein histidine kinase activity
DM194_RS20440	COG0784	Response regulator, receiver
DM194_RS20440	COG2198	Histidine kinase
DM194_RS20455	COG1253	flavin adenine dinucleotide binding
DM194_RS20470	COG2205	protein histidine kinase activity
DM194_RS20470	COG2198	Histidine kinase
DM194_RS20470	COG0784	Response regulator, receiver
DM194_RS20480	COG1396	sequence-specific DNA binding
DM194_RS20485	COG1766	The M ring may be actively involved in energy transduction
DM194_RS20495	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DM194_RS20500	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DM194_RS20505	COG2204	response regulator
DM194_RS20510	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DM194_RS20530	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DM194_RS20535	COG1320	monovalent cation:proton antiporter activity
DM194_RS20540	COG2212	antiporter activity
DM194_RS20545	COG1863	multisubunit Na H antiporter MnhE subunit
DM194_RS20550	COG0651	ATP synthesis coupled electron transport
DM194_RS20555	COG1006	Multisubunit Na H antiporter MnhC subunit
DM194_RS20560	COG2111	Na H antiporter
DM194_RS20560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DM194_RS20565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM194_RS20575	COG4191	Histidine kinase
DM194_RS20605	COG1446	asparaginase
DM194_RS20610	COG2362	D-Aminopeptidase
DM194_RS20620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DM194_RS20630	COG0747	negative chemotaxis
DM194_RS20635	COG4172	Belongs to the ABC transporter superfamily
DM194_RS20650	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DM194_RS20665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DM194_RS20670	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DM194_RS20675	COG1984	allophanate hydrolase subunit 2
DM194_RS20680	COG3842	ATPase activity
DM194_RS20685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DM194_RS20690	COG1176	ABC-type spermidine putrescine transport system, permease component I
DM194_RS20695	COG1177	transmembrane transport
DM194_RS20710	COG0154	amidase activity
DM194_RS20715	COG1802	Transcriptional regulator
DM194_RS20720	COG3706	GGDEF domain
DM194_RS20750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DM194_RS20760	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS20765	COG0583	DNA-binding transcription factor activity
DM194_RS20775	COG3483	tryptophan 2,3-dioxygenase activity
DM194_RS20785	COG2207	Transcriptional regulator
DM194_RS20840	COG0745	RESPONSE REGULATOR receiver
DM194_RS20850	COG3279	Response regulator of the LytR AlgR family
DM194_RS20855	COG3275	phosphorelay sensor kinase activity
DM194_RS20860	COG0814	amino acid
DM194_RS20865	COG1760	l-serine dehydratase
DM194_RS20875	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS20885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM194_RS20890	COG1116	anion transmembrane transporter activity
DM194_RS20925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DM194_RS20935	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DM194_RS21005	COG0583	DNA-binding transcription factor activity
DM194_RS21015	COG0747	negative chemotaxis
DM194_RS21020	COG0601	transmembrane transport
DM194_RS21025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DM194_RS21115	COG0861	Integral membrane protein TerC family
DM194_RS21135	COG0277	FAD linked oxidase domain protein
DM194_RS21145	COG3842	ATPase activity
DM194_RS21150	COG1176	ABC-type spermidine putrescine transport system, permease component I
DM194_RS21155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DM194_RS21170	COG4221	oxidoreductase activity
DM194_RS21175	COG1177	transmembrane transport
DM194_RS21220	COG0251	oxidation-reduction process
DM194_RS21230	COG0251	oxidation-reduction process
DM194_RS21235	COG1012	belongs to the aldehyde dehydrogenase family
DM194_RS21235	COG1454	alcohol dehydrogenase
DM194_RS21240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DM194_RS21245	COG4566	intracellular signal transduction
DM194_RS21250	COG4566	intracellular signal transduction
DM194_RS21255	COG4191	Histidine kinase
DM194_RS21270	COG4626	Terminase
DM194_RS21270	COG1802	Transcriptional regulator
DM194_RS21300	COG4214	carbohydrate transport
DM194_RS21305	COG4213	ABC transporter substrate-binding protein
DM194_RS21310	COG2115	Belongs to the xylose isomerase family
DM194_RS21315	COG1070	Carbohydrate kinase
DM194_RS21320	COG1609	Transcriptional regulator
DM194_RS21340	COG2353	YceI-like domain
DM194_RS21345	COG0435	Glutathione S-transferase
DM194_RS21350	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS21360	COG0667	Aldo Keto reductase
DM194_RS21365	COG3381	protein complex oligomerization
DM194_RS21370	COG3302	dmso reductase anchor subunit
DM194_RS21375	COG0437	4 iron, 4 sulfur cluster binding
DM194_RS21380	COG0243	molybdopterin cofactor binding
DM194_RS21385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DM194_RS21405	COG0567	Dehydrogenase, E1 component
DM194_RS21410	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DM194_RS21425	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DM194_RS21435	COG0277	FAD linked oxidase domain protein
DM194_RS21440	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
DM194_RS21450	COG2086	electron transfer activity
DM194_RS21460	COG4459	periplasmic nitrate reductase
DM194_RS21470	COG3062	negative regulation of establishment of protein localization
DM194_RS21485	COG3005	denitrification pathway
DM194_RS21490	COG1475	DNA binding
DM194_RS21495	COG1192	Involved in chromosome partitioning
DM194_RS21505	COG1278	Cold shock
DM194_RS21510	COG1192	Involved in chromosome partitioning
DM194_RS21555	COG4372	Transposase
DM194_RS21560	COG3436	PFAM IS66 Orf2 family protein
DM194_RS21585	COG3547	Transposase (IS116 IS110 IS902 family)
DM194_RS21630	COG0730	response to heat
DM194_RS21665	COG2814	Major facilitator Superfamily
DM194_RS21675	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DM194_RS21680	COG1140	nitrate reductase beta subunit
DM194_RS21685	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DM194_RS21690	COG2181	nitrate reductase activity
DM194_RS21695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DM194_RS21700	COG2223	nitrite transmembrane transporter activity
DM194_RS21720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM194_RS21725	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DM194_RS21785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DM194_RS21790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DM194_RS21805	COG0402	S-adenosylhomocysteine deaminase activity
DM194_RS21810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DM194_RS21835	COG0583	DNA-binding transcription factor activity
DM194_RS21840	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM194_RS21865	COG1335	isochorismatase
DM194_RS21870	COG2309	aminopeptidase activity
DM194_RS21875	COG0596	Alpha beta hydrolase
DM194_RS21880	COG3473	Maleate cis-trans isomerase
DM194_RS21885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DM194_RS21895	COG0411	ABC transporter
DM194_RS21910	COG0683	leucine binding
DM194_RS21915	COG0513	Belongs to the DEAD box helicase family
DM194_RS21925	COG1278	Cold shock
DM194_RS21935	COG0490	domain, Protein
DM194_RS21935	COG0471	metal ion transport
DM194_RS21940	COG0546	phosphoglycolate phosphatase activity
DM194_RS21955	COG0251	oxidation-reduction process
DM194_RS22010	COG3547	Transposase (IS116 IS110 IS902 family)
DM194_RS22030	COG3210	domain, Protein
DM194_RS22045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DM194_RS22095	COG0154	amidase activity
DM194_RS22120	COG0501	Belongs to the peptidase M48B family
DM194_RS22130	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DM194_RS22140	COG0586	Pfam SNARE associated Golgi protein
DM194_RS22165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DM194_RS22170	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DM194_RS22180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM194_RS22200	COG3437	response regulator, receiver
DM194_RS22210	COG0405	Gamma-glutamyltransferase
DM194_RS22250	COG3806	Anti-sigma factor
DM194_RS22255	COG1595	DNA-templated transcription, initiation
DM194_RS22260	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DM194_RS22270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DM194_RS22285	COG4221	oxidoreductase activity
DM194_RS22300	COG0848	biopolymer transport protein
DM194_RS22360	COG0628	permease
DM194_RS22370	COG1522	sequence-specific DNA binding
DM194_RS22375	COG0438	transferase activity, transferring glycosyl groups
DM194_RS22390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DM194_RS22400	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DM194_RS22410	COG3206	protein involved in exopolysaccharide biosynthesis
DM194_RS22410	COG0489	protein tyrosine kinase activity
DM194_RS22430	COG1131	(ABC) transporter
DM194_RS22440	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DM194_RS22455	COG0402	S-adenosylhomocysteine deaminase activity
DM194_RS22475	COG0784	Response regulator, receiver
DM194_RS22485	COG3214	Protein conserved in bacteria
DM194_RS22490	COG1522	sequence-specific DNA binding
DM194_RS22495	COG0586	Pfam SNARE associated Golgi protein
DM194_RS22515	COG2233	PERMEase
DM194_RS22525	COG2723	6-phospho-beta-galactosidase activity
DM194_RS22540	COG1295	ribonuclease BN
DM194_RS22575	COG0793	Belongs to the peptidase S41A family
DM194_RS22585	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DM194_RS22590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DM194_RS22595	COG0671	phosphoesterase, PA-phosphatase related
DM194_RS22615	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DM194_RS22625	COG3012	SEC-C Motif Domain Protein
DM194_RS22630	COG1278	Cold shock
DM194_RS22650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DM194_RS22670	COG4303	Ethanolamine ammonia lyase large subunit
DM194_RS22690	COG1280	lysine exporter protein (LysE YggA)
DM194_RS22700	COG0427	acetyl-CoA hydrolase
DM194_RS22710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DM194_RS22715	COG2205	protein histidine kinase activity
DM194_RS22715	COG2202	Pas domain
DM194_RS22730	COG1012	belongs to the aldehyde dehydrogenase family
DM194_RS22735	COG2864	formate dehydrogenase
DM194_RS22740	COG0437	4 iron, 4 sulfur cluster binding
DM194_RS22745	COG3383	formate dehydrogenase (NAD+) activity
DM194_RS22745	COG0243	molybdopterin cofactor binding
DM194_RS22765	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DM194_RS22785	COG4948	Mandelate Racemase Muconate Lactonizing
DM194_RS22790	COG0583	DNA-binding transcription factor activity
DM194_RS22825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DM194_RS22840	COG1764	response to oxidative stress
DM194_RS22850	COG5002	protein histidine kinase activity
DM194_RS22865	COG3396	Phenylacetate-CoA oxygenase
DM194_RS22870	COG3460	Phenylacetate-CoA oxygenase
DM194_RS22875	COG3396	Phenylacetate-CoA oxygenase
DM194_RS22880	COG2151	metal-sulfur cluster biosynthetic enzyme
DM194_RS22885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DM194_RS22890	COG1012	belongs to the aldehyde dehydrogenase family
DM194_RS22895	COG1024	Enoyl-CoA hydratase
DM194_RS22900	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM194_RS22905	COG2050	protein possibly involved in aromatic compounds catabolism
DM194_RS22910	COG0183	Belongs to the thiolase family
DM194_RS22930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM194_RS22935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM194_RS22945	COG1802	Transcriptional regulator
DM194_RS22950	COG1803	Methylglyoxal synthase
DM194_RS22955	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DM194_RS22960	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS22965	COG1917	Cupin 2, conserved barrel domain protein
DM194_RS22975	COG1904	glucuronate isomerase
DM194_RS22980	COG2721	sulfolactate sulfo-lyase activity
DM194_RS22990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DM194_RS22995	COG1309	transcriptional regulator
DM194_RS23000	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS23025	COG1309	transcriptional regulator
DM194_RS23040	COG0643	Histidine kinase
DM194_RS23040	COG2198	Histidine kinase
DM194_RS23050	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DM194_RS23060	COG2201	protein-glutamate methylesterase activity
DM194_RS23065	COG0835	chemotaxis
DM194_RS23070	COG0840	transmembrane signaling receptor activity
DM194_RS23075	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DM194_RS23075	COG1776	CheC inhibitor of MCP methylation
DM194_RS23080	COG2201	protein-glutamate methylesterase activity
DM194_RS23085	COG0457	Tetratricopeptide repeat
DM194_RS23085	COG0859	PFAM glycosyl transferase family 9
DM194_RS23090	COG1464	Belongs to the NlpA lipoprotein family
DM194_RS23095	COG2011	ABC-type metal ion transport system permease component
DM194_RS23100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DM194_RS23120	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DM194_RS23130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DM194_RS23155	COG1530	ribonuclease E activity
DM194_RS23160	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DM194_RS23175	COG1045	serine acetyltransferase
DM194_RS23195	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DM194_RS23265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DM194_RS23270	COG0347	Belongs to the P(II) protein family
DM194_RS23280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DM194_RS23290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DM194_RS23295	COG1121	(ABC) transporter
DM194_RS23315	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DM194_RS23320	COG3437	response regulator, receiver
DM194_RS23320	COG0784	Response regulator, receiver
DM194_RS23325	COG1280	lysine exporter protein (LysE YggA)
DM194_RS23340	COG3800	Transcriptional regulator
DM194_RS23340	COG1396	sequence-specific DNA binding
DM194_RS23345	COG2224	Isocitrate lyase
DM194_RS23350	COG0693	protein deglycase activity
DM194_RS23355	COG0840	transmembrane signaling receptor activity
DM194_RS23360	COG0287	Prephenate dehydrogenase
DM194_RS23365	COG0583	DNA-binding transcription factor activity
DM194_RS23400	COG3436	PFAM IS66 Orf2 family protein
DM194_RS23405	COG4372	Transposase
DM194_RS23430	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DM194_RS23445	COG2814	Major facilitator Superfamily
DM194_RS23460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM194_RS23465	COG4597	amino acid ABC transporter
DM194_RS23470	COG0765	amino acid transport
DM194_RS23475	COG1126	abc transporter atp-binding protein
DM194_RS23485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM194_RS23510	COG0683	leucine binding
DM194_RS23515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DM194_RS23520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DM194_RS23530	COG3485	protocatechuate 3,4-dioxygenase
DM194_RS23535	COG3485	protocatechuate 3,4-dioxygenase
DM194_RS23540	COG0840	transmembrane signaling receptor activity
DM194_RS23545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DM194_RS23550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DM194_RS23565	COG1609	Transcriptional regulator
DM194_RS23570	COG2972	Histidine kinase
DM194_RS23570	COG0840	transmembrane signaling receptor activity
DM194_RS23575	COG0300	oxidoreductase activity
DM194_RS23585	COG0116	Belongs to the methyltransferase superfamily
DM194_RS23585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DM194_RS23615	COG0564	pseudouridine synthase activity
DM194_RS23625	COG0454	-acetyltransferase
DM194_RS23650	COG0667	Aldo Keto reductase
DM194_RS23655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DM194_RS23660	COG1192	Involved in chromosome partitioning
DM194_RS23675	COG1393	Belongs to the ArsC family
DM194_RS23680	COG0798	PFAM Bile acid sodium symporter
DM194_RS23685	COG0431	NADPH-dependent FMN reductase
DM194_RS23695	COG1960	acyl-CoA dehydrogenase activity
DM194_RS23725	COG3210	domain, Protein
DM194_RS23730	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DM194_RS23745	COG4172	Belongs to the ABC transporter superfamily
DM194_RS23755	COG0601	transmembrane transport
DM194_RS23760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DM194_RS23775	COG0438	transferase activity, transferring glycosyl groups
DM194_RS23780	COG0588	phosphoglycerate mutase activity
DM194_RS23795	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DM194_RS23825	COG0667	Aldo Keto reductase
DM194_RS23830	COG2814	Major facilitator Superfamily
DM194_RS23875	COG0204	Acyl-transferase
DM194_RS23875	COG0318	PFAM AMP-dependent synthetase and ligase
DM194_RS23880	COG2884	Cell division ATP-binding protein ftsE
DM194_RS23900	COG2217	Heavy metal translocating P-type atpase
DM194_RS23905	COG2610	gluconate transmembrane transporter activity
DM194_RS23910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DM194_RS23915	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DM194_RS23920	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS23955	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DM194_RS23955	COG1672	PFAM Archaeal ATPase
DM194_RS23960	COG0129	dihydroxy-acid dehydratase activity
DM194_RS24000	COG0583	DNA-binding transcription factor activity
DM194_RS24015	COG0564	pseudouridine synthase activity
DM194_RS24025	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DM194_RS24035	COG0842	Transport permease protein
DM194_RS24040	COG1129	ABC transporter
DM194_RS24040	COG0842	Transport permease protein
DM194_RS24045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM194_RS24050	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DM194_RS24055	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DM194_RS24080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM194_RS24085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM194_RS24095	COG1802	Transcriptional regulator
DM194_RS24105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DM194_RS24125	COG0840	transmembrane signaling receptor activity
DM194_RS24160	COG0686	Belongs to the AlaDH PNT family
DM194_RS24165	COG1522	sequence-specific DNA binding
DM194_RS24170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DM194_RS24185	COG2205	protein histidine kinase activity
DM194_RS24185	COG0784	Response regulator, receiver
DM194_RS24185	COG2198	Histidine kinase
DM194_RS24210	COG2202	Pas domain
DM194_RS24210	COG2205	protein histidine kinase activity
DM194_RS24220	COG0306	phosphate transporter
DM194_RS24235	COG0019	diaminopimelate decarboxylase activity
DM194_RS24250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DM194_RS24265	COG2084	Dehydrogenase
DM194_RS24270	COG3622	Belongs to the hyi family
DM194_RS24275	COG0446	pyridine nucleotide-disulphide oxidoreductase
DM194_RS24275	COG1902	pentaerythritol trinitrate reductase activity
DM194_RS24280	COG1802	Transcriptional regulator
DM194_RS24290	COG0861	Integral membrane protein TerC family
DM194_RS24295	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DM194_RS24305	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DM194_RS24310	COG0604	alcohol dehydrogenase
DM194_RS24320	COG0778	Nitroreductase
DM194_RS24325	COG1797	cobyrinic acid a,c-diamide synthase activity
DM194_RS24355	COG2099	Precorrin-6x reductase
DM194_RS24415	COG0559	Belongs to the binding-protein-dependent transport system permease family
DM194_RS24435	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DM194_RS24480	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DM194_RS24500	COG1028	Short-chain dehydrogenase reductase Sdr
DM194_RS24505	COG0443	Heat shock 70 kDa protein
DM194_RS24510	COG2985	domain, Protein
DM194_RS24515	COG0489	protein tyrosine kinase activity
DM194_RS24520	COG0330	HflC and HflK could
DM194_RS24525	COG0330	HflC and HflK could
DM194_RS24530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DM194_RS24535	COG2197	response regulator
DM194_RS24545	COG0583	DNA-binding transcription factor activity
DM194_RS24550	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DM194_RS24570	COG3920	Histidine kinase
DM194_RS24585	COG2205	protein histidine kinase activity
DM194_RS24600	COG0643	Histidine kinase
DM194_RS24600	COG2198	Histidine kinase
DM194_RS24600	COG0784	Response regulator, receiver
DM194_RS24605	COG0835	chemotaxis
DM194_RS24610	COG0745	RESPONSE REGULATOR receiver
DM194_RS24635	COG1278	Cold shock
DM194_RS24640	COG0745	RESPONSE REGULATOR receiver
DM194_RS24690	COG0406	alpha-ribazole phosphatase activity
DM194_RS24705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DM194_RS24710	COG1032	radical SAM domain protein
DM194_RS24735	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DM194_RS24750	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DM194_RS24755	COG1845	cytochrome c oxidase, subunit III
DM194_RS24760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DM194_RS24765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DM194_RS24770	COG0477	Major facilitator Superfamily
DM194_RS24815	COG1988	membrane-bound metal-dependent
DM194_RS24845	COG4178	(ABC) transporter
DM194_RS24860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DM194_RS24870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DM194_RS24915	COG4993	Dehydrogenase
DM194_RS24920	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM194_RS24930	COG2086	electron transfer activity
DM194_RS24945	COG2723	6-phospho-beta-galactosidase activity
DM194_RS24950	COG2249	NAD(P)H dehydrogenase (quinone) activity
DM194_RS24975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DM194_RS24980	COG1127	ABC transporter
DM194_RS24985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DM194_RS24990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DM194_RS24995	COG0305	Participates in initiation and elongation during chromosome replication
DM194_RS25010	COG2010	Cytochrome c
DM194_RS25025	COG0598	Magnesium transport protein CorA
DM194_RS25040	COG0840	transmembrane signaling receptor activity
DM194_RS25055	COG0784	Response regulator, receiver
DM194_RS25060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DM194_RS25080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DM194_RS25085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DM194_RS25090	COG1127	ABC transporter
DM194_RS25095	COG3218	ABC-type transport auxiliary lipoprotein component
DM194_RS25095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DM194_RS25115	COG2202	Pas domain
DM194_RS25115	COG2205	protein histidine kinase activity
DM194_RS25125	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DM194_RS25140	COG2703	oxygen carrier activity
DM194_RS25155	COG0521	Mo-molybdopterin cofactor biosynthetic process
DM194_RS25160	COG0741	lytic transglycosylase activity
DM194_RS25165	COG1573	uracil-dna glycosylase
DM194_RS25185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM194_RS25200	COG1139	Iron-sulfur cluster binding protein
DM194_RS25205	COG0247	lactate metabolic process
DM194_RS25220	COG2204	response regulator
DM194_RS25235	COG0372	Belongs to the citrate synthase family
DM194_RS25250	COG2205	protein histidine kinase activity
DM194_RS25250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM194_RS25270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM194_RS25280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DM194_RS25300	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DM194_RS25315	COG2814	Major facilitator Superfamily
DM194_RS25340	COG0840	transmembrane signaling receptor activity
DM194_RS25350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DM194_RS25405	COG0516	GMP reductase activity
DM194_RS25410	COG1349	DNA-binding transcription factor activity
DM194_RS25425	COG3842	ATPase activity
DM194_RS25450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DM194_RS25455	COG0318	PFAM AMP-dependent synthetase and ligase
DM194_RS25485	COG1858	cytochrome C peroxidase
DM194_RS25505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM194_RS25505	COG4191	Histidine kinase
DM194_RS25525	COG0463	Glycosyl transferase, family 2
DM194_RS25545	COG1940	carbohydrate kinase activity
DM194_RS25600	COG2885	chlorophyll binding
DM194_RS25600	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DM194_RS25605	COG2197	response regulator
DM194_RS25620	COG1737	Transcriptional regulator
DM194_RS25625	COG0179	Fumarylacetoacetate (FAA) hydrolase
DM194_RS25645	COG3604	Transcriptional regulator
DM194_RS25655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DM194_RS25655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DM194_RS25670	COG3829	transcription factor binding
DM194_RS25670	COG3290	protein histidine kinase activity
DM194_RS25680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DM194_RS25695	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DM194_RS25700	COG1063	alcohol dehydrogenase
DM194_RS25705	COG0246	Mannitol dehydrogenase
DM194_RS25710	COG1802	Transcriptional regulator
DM194_RS25715	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DM194_RS25750	COG1032	radical SAM domain protein
DM194_RS25765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DM194_RS25775	COG0573	inorganic phosphate transmembrane transporter activity
DM194_RS25780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DM194_RS25790	COG0625	glutathione transferase activity
DM194_RS25800	COG0569	domain protein
DM194_RS25805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DM194_RS25830	COG3663	DNA glycosylase
DM194_RS25900	COG0318	PFAM AMP-dependent synthetase and ligase
DM194_RS25905	COG3619	membrane
DM194_RS25930	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM194_RS25935	COG0351	phosphomethylpyrimidine kinase
DM194_RS25940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DM194_RS25945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DM194_RS25950	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DM194_RS25960	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DM194_RS25975	COG1677	Flagellar hook-basal body complex protein FliE
DM194_RS25980	COG1558	bacterial-type flagellum-dependent cell motility
DM194_RS26020	COG5443	negative regulation of bacterial-type flagellum assembly
DM194_RS26030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DM194_RS26035	COG0745	RESPONSE REGULATOR receiver
DM194_RS26050	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DM194_RS26060	COG1338	Plays a role in the flagellum-specific transport system
DM194_RS26065	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DM194_RS26075	COG1766	The M ring may be actively involved in energy transduction
DM194_RS26115	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DM194_RS26125	COG4786	Flagellar basal body rod
DM194_RS26130	COG4786	Flagellar basal body rod
DM194_RS26140	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DM194_RS26145	COG1360	Flagellar Motor Protein
DM194_RS26150	COG1749	Flagellar hook protein flgE
DM194_RS26155	COG1256	bacterial-type flagellum assembly
DM194_RS26165	COG1706	bacterial-type flagellum-dependent cell motility
DM194_RS26190	COG3436	PFAM IS66 Orf2 family protein
DM194_RS26195	COG4372	Transposase
DM194_RS26225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DM194_RS26235	COG4191	Histidine kinase
DM194_RS26235	COG0784	Response regulator, receiver
DM194_RS26255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DM194_RS26275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM194_RS26280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM194_RS26285	COG1309	transcriptional regulator
DM194_RS26295	COG0644	oxidoreductase
DM194_RS26305	COG1192	Involved in chromosome partitioning
DM194_RS26310	COG1253	flavin adenine dinucleotide binding
DM194_RS26340	COG1609	Transcriptional regulator
DM194_RS26345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DM194_RS26350	COG2814	Major facilitator Superfamily
DM194_RS26370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM194_RS26375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM194_RS26390	COG0251	oxidation-reduction process
DM194_RS26400	COG0129	dihydroxy-acid dehydratase activity
DM194_RS26410	COG4214	carbohydrate transport
DM194_RS26415	COG1129	ABC transporter
DM194_RS26445	COG1879	ABC-type sugar transport system periplasmic component
DM194_RS26450	COG1129	ABC transporter
DM194_RS26455	COG1172	Belongs to the binding-protein-dependent transport system permease family
DM194_RS26460	COG1172	Belongs to the binding-protein-dependent transport system permease family
DM194_RS26470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DM194_RS26500	COG0656	L-ascorbic acid biosynthetic process
DM194_RS26505	COG1116	anion transmembrane transporter activity
DM194_RS26515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DM194_RS26520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DM194_RS26530	COG0243	molybdopterin cofactor binding
DM194_RS26540	COG1648	precorrin-2 dehydrogenase activity
DM194_RS26540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DM194_RS26545	COG0791	NLP P60 protein
DM194_RS26605	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DM194_RS26655	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DM194_RS26665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DM194_RS26670	COG0022	dehydrogenase e1 component
DM194_RS26685	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DM194_RS26720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DM194_RS26725	COG3848	Pyruvate phosphate dikinase
DM194_RS26725	COG0574	Belongs to the PEP-utilizing enzyme family
DM194_RS26735	COG0529	Catalyzes the synthesis of activated sulfate
DM194_RS26755	COG1032	radical SAM domain protein
DM194_RS26765	COG0494	nUDIX hydrolase
DM194_RS26800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DM194_RS26805	COG0438	transferase activity, transferring glycosyl groups
DM194_RS26830	COG1309	transcriptional regulator
DM194_RS26835	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DM194_RS26840	COG2226	methyltransferase
DM194_RS26845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DM194_RS26855	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DM194_RS26915	COG0675	Transposase, IS605 OrfB family
DM194_RS26930	COG0463	Glycosyl transferase, family 2
DM194_RS26945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DM194_RS26950	COG2264	protein methyltransferase activity
DM194_RS26955	COG0438	transferase activity, transferring glycosyl groups
DM194_RS26975	COG1192	Involved in chromosome partitioning
DM194_RS26995	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DM194_RS27045	COG4191	Histidine kinase
DM194_RS27045	COG0784	Response regulator, receiver
DM194_RS27085	COG4566	intracellular signal transduction
DM194_RS27085	COG0745	RESPONSE REGULATOR receiver
DM194_RS27105	COG0745	RESPONSE REGULATOR receiver
DM194_RS27110	COG2205	protein histidine kinase activity
DM194_RS27115	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DM194_RS27120	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DM194_RS27125	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DM194_RS27135	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DM194_RS27150	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DM194_RS27165	COG2217	Heavy metal translocating P-type atpase
DM194_RS27170	COG0789	Transcriptional regulator
DM194_RS27180	COG1686	Belongs to the peptidase S11 family
DM194_RS27190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DM194_RS27200	COG2321	neutral zinc metallopeptidase
DM194_RS27245	COG0175	sulfate reduction
DM194_RS27265	COG1216	Glycosyl transferase, family 2
DM194_RS27265	COG0438	transferase activity, transferring glycosyl groups
DM194_RS27270	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DM194_RS27280	COG1091	dTDP-4-dehydrorhamnose reductase activity
DM194_RS27290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DM194_RS27315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM194_RS27320	COG2274	protein secretion by the type I secretion system
DM194_RS27330	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DM194_RS27330	COG0662	Cupin 2, conserved barrel domain protein
DM194_RS27360	COG1086	Polysaccharide biosynthesis protein
DM194_RS27365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DM194_RS27430	COG0463	Glycosyl transferase, family 2
DM194_RS27495	COG4638	Rieske (2fe-2S)
DM194_RS27510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DM194_RS27550	COG0438	transferase activity, transferring glycosyl groups
DM194_RS27570	COG4520	surface antigen
DM194_RS27615	COG0270	DNA (cytosine-5-)-methyltransferase activity
DM194_RS27630	COG3727	T/G mismatch-specific endonuclease activity
DM194_RS27655	COG2226	methyltransferase
DM194_RS27805	COG2197	response regulator
DM194_RS27825	COG0483	inositol monophosphate 1-phosphatase activity
DM194_RS27845	COG1846	Transcriptional regulator
DM194_RS27850	COG1764	response to oxidative stress
DM194_RS27865	COG0583	DNA-binding transcription factor activity
DM194_RS27870	COG0251	oxidation-reduction process
DM194_RS27880	COG1733	regulation of RNA biosynthetic process
DM194_RS27890	COG0596	Alpha beta hydrolase
DM194_RS27940	COG1074	ATP-dependent DNA helicase activity
DM194_RS27950	COG0574	Belongs to the PEP-utilizing enzyme family
DM194_RS27950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DM194_RS28245	COG0444	Belongs to the ABC transporter superfamily