locus-tag	class	description
AZL_RS00025	COG0237	dephospho-CoA kinase activity
AZL_RS00030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AZL_RS00040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AZL_RS00045	COG1331	Highly conserved protein containing a thioredoxin domain
AZL_RS00065	COG0445	tRNA wobble uridine modification
AZL_RS00085	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AZL_RS00090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AZL_RS00095	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AZL_RS00100	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AZL_RS00105	COG0280	phosphate acetyltransferase
AZL_RS00105	COG0281	malic enzyme
AZL_RS00120	COG5002	protein histidine kinase activity
AZL_RS00125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AZL_RS00130	COG0573	inorganic phosphate transmembrane transporter activity
AZL_RS00140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AZL_RS00145	COG0745	RESPONSE REGULATOR receiver
AZL_RS00155	COG0670	Belongs to the BI1 family
AZL_RS00165	COG4181	ATPase activity
AZL_RS00180	COG0667	Aldo Keto reductase
AZL_RS00185	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AZL_RS00200	COG3706	GGDEF domain
AZL_RS00210	COG0443	Heat shock 70 kDa protein
AZL_RS00230	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AZL_RS00250	COG4957	zinc ion binding
AZL_RS00300	COG4584	PFAM Integrase catalytic
AZL_RS00305	COG1484	DNA-dependent DNA replication
AZL_RS00355	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AZL_RS00365	COG0745	RESPONSE REGULATOR receiver
AZL_RS00370	COG0642	Histidine kinase
AZL_RS00385	COG1660	Displays ATPase and GTPase activities
AZL_RS00390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AZL_RS00390	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AZL_RS00400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AZL_RS00415	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AZL_RS00435	COG0271	Belongs to the BolA IbaG family
AZL_RS00460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AZL_RS00475	COG4974	Belongs to the 'phage' integrase family
AZL_RS00485	COG2154	pterin-4-alpha-carbinolamine dehydratase
AZL_RS00495	COG1573	uracil-dna glycosylase
AZL_RS00505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AZL_RS00510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AZL_RS00515	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AZL_RS00520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AZL_RS00550	COG2223	nitrite transmembrane transporter activity
AZL_RS00570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AZL_RS00570	COG0517	IMP dehydrogenase activity
AZL_RS00585	COG1137	ATPase activity
AZL_RS00590	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AZL_RS00595	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AZL_RS00600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AZL_RS00605	COG4636	protein conserved in cyanobacteria
AZL_RS00610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AZL_RS00615	COG0527	aspartate kinase activity
AZL_RS00620	COG2070	2-Nitropropane dioxygenase
AZL_RS00645	COG2885	chlorophyll binding
AZL_RS00650	COG1484	DNA-dependent DNA replication
AZL_RS00655	COG4584	PFAM Integrase catalytic
AZL_RS00685	COG4964	Belongs to the GSP D family
AZL_RS00745	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AZL_RS00750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AZL_RS00760	COG2890	protein-(glutamine-N5) methyltransferase activity
AZL_RS00780	COG0542	response to heat
AZL_RS00810	COG3162	membrane
AZL_RS00830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AZL_RS00850	COG4106	trans-aconitate 2-methyltransferase activity
AZL_RS00870	COG5001	Diguanylate cyclase
AZL_RS00880	COG1473	amidohydrolase
AZL_RS00885	COG0625	glutathione transferase activity
AZL_RS00890	COG3813	Protein conserved in bacteria
AZL_RS00895	COG3437	response regulator, receiver
AZL_RS00895	COG0784	Response regulator, receiver
AZL_RS00910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AZL_RS00950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AZL_RS01040	COG3339	Conserved Protein
AZL_RS01050	COG2423	ornithine cyclodeaminase activity
AZL_RS01060	COG0776	regulation of translation
AZL_RS01075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AZL_RS01095	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AZL_RS01105	COG0783	Belongs to the Dps family
AZL_RS01115	COG0840	transmembrane signaling receptor activity
AZL_RS01120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AZL_RS01130	COG0137	argininosuccinate synthase activity
AZL_RS01165	COG1272	protein, Hemolysin III
AZL_RS01250	COG0583	DNA-binding transcription factor activity
AZL_RS01265	COG1024	Enoyl-CoA hydratase
AZL_RS01275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AZL_RS01275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AZL_RS01285	COG0138	bifunctional purine biosynthesis protein purh
AZL_RS01305	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AZL_RS01310	COG0583	DNA-binding transcription factor activity
AZL_RS01320	COG0861	Integral membrane protein TerC family
AZL_RS01325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AZL_RS01335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AZL_RS01375	COG3660	Nucleoside-diphosphate-sugar epimerase
AZL_RS01380	COG1522	sequence-specific DNA binding
AZL_RS01395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AZL_RS01400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AZL_RS01425	COG3005	denitrification pathway
AZL_RS01435	COG0243	molybdopterin cofactor binding
AZL_RS01455	COG0642	Histidine kinase
AZL_RS01475	COG2318	DinB family
AZL_RS01480	COG1674	ftsk spoiiie
AZL_RS01490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AZL_RS01500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AZL_RS01505	COG1238	metal cluster binding
AZL_RS01570	COG0539	negative regulation of cytoplasmic translation
AZL_RS01580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AZL_RS01590	COG0574	Belongs to the PEP-utilizing enzyme family
AZL_RS01590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AZL_RS01615	COG0583	DNA-binding transcription factor activity
AZL_RS01620	COG0297	glycogen (starch) synthase activity
AZL_RS01625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AZL_RS01630	COG0004	ammonium transporteR
AZL_RS01635	COG1741	Belongs to the pirin family
AZL_RS01655	COG2313	pseudouridylate synthase activity
AZL_RS01665	COG1793	dna ligase
AZL_RS01690	COG1028	Short-chain dehydrogenase reductase Sdr
AZL_RS01705	COG0156	8-amino-7-oxononanoate synthase activity
AZL_RS01715	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AZL_RS01725	COG0135	phosphoribosylanthranilate isomerase activity
AZL_RS01740	COG5265	(ABC) transporter
AZL_RS01745	COG0840	transmembrane signaling receptor activity
AZL_RS01755	COG1177	transmembrane transport
AZL_RS01775	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AZL_RS01785	COG3278	Belongs to the heme-copper respiratory oxidase family
AZL_RS01815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AZL_RS01820	COG1612	heme a metabolic process
AZL_RS01825	COG3772	lysozyme
AZL_RS01835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AZL_RS01840	COG0459	protein refolding
AZL_RS01855	COG4566	intracellular signal transduction
AZL_RS01875	COG0583	DNA-binding transcription factor activity
AZL_RS01910	COG4608	Belongs to the ABC transporter superfamily
AZL_RS01915	COG0444	Belongs to the ABC transporter superfamily
AZL_RS01920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AZL_RS01925	COG0601	transmembrane transport
AZL_RS01930	COG0492	ferredoxin-NADP+ reductase activity
AZL_RS01940	COG1695	Transcriptional regulator
AZL_RS01955	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AZL_RS01965	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AZL_RS01980	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AZL_RS01985	COG1595	DNA-templated transcription, initiation
AZL_RS02010	COG2202	Pas domain
AZL_RS02010	COG2205	protein histidine kinase activity
AZL_RS02030	COG0625	glutathione transferase activity
AZL_RS02035	COG0454	-acetyltransferase
AZL_RS02035	COG0456	acetyltransferase
AZL_RS02040	COG2358	TRAP transporter, solute receptor (TAXI family
AZL_RS02060	COG0825	malonyl-CoA metabolic process
AZL_RS02070	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AZL_RS02075	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AZL_RS02080	COG1842	Phage shock protein A
AZL_RS02090	COG1983	PspC domain protein
AZL_RS02105	COG1442	glycosyl transferase family 8
AZL_RS02105	COG1216	Glycosyl transferase, family 2
AZL_RS02135	COG0181	hydroxymethylbilane synthase activity
AZL_RS02145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AZL_RS02160	COG0587	DNA-directed DNA polymerase activity
AZL_RS02175	COG0784	Response regulator, receiver
AZL_RS02175	COG3437	response regulator, receiver
AZL_RS02180	COG3158	transport of potassium into the cell
AZL_RS02200	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AZL_RS02205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AZL_RS02210	COG0842	Transport permease protein
AZL_RS02215	COG2137	regulation of response to DNA damage stimulus
AZL_RS02220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AZL_RS02230	COG1703	isobutyryl-CoA mutase activity
AZL_RS02235	COG4172	Belongs to the ABC transporter superfamily
AZL_RS02240	COG4239	(ABC) transporter, permease
AZL_RS02245	COG4174	ABC transporter (Permease)
AZL_RS02250	COG4166	transmembrane transport
AZL_RS02255	COG4166	transmembrane transport
AZL_RS02285	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AZL_RS02290	COG3474	cytochrome
AZL_RS02305	COG2766	serine protein kinase
AZL_RS02310	COG2718	Belongs to the UPF0229 family
AZL_RS02315	COG2719	SpoVR family
AZL_RS02320	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AZL_RS02335	COG0318	PFAM AMP-dependent synthetase and ligase
AZL_RS02340	COG1254	Belongs to the acylphosphatase family
AZL_RS02375	COG2239	Acts as a magnesium transporter
AZL_RS02380	COG2022	thiamine diphosphate biosynthetic process
AZL_RS02380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AZL_RS02390	COG2022	thiamine diphosphate biosynthetic process
AZL_RS02475	COG3436	PFAM IS66 Orf2 family protein
AZL_RS02490	COG4584	PFAM Integrase catalytic
AZL_RS02505	COG4717	serine-type aminopeptidase activity
AZL_RS02510	COG0420	3'-5' exonuclease activity
AZL_RS02525	COG0803	Belongs to the bacterial solute-binding protein 9 family
AZL_RS02550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AZL_RS02560	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AZL_RS02570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AZL_RS02575	COG3108	Peptidase M15
AZL_RS02580	COG2003	Belongs to the UPF0758 family
AZL_RS02595	COG0642	Histidine kinase
AZL_RS02600	COG0745	RESPONSE REGULATOR receiver
AZL_RS02605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AZL_RS02610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AZL_RS02625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AZL_RS02630	COG0277	FAD linked oxidase domain protein
AZL_RS02635	COG0277	FAD linked oxidase domain protein
AZL_RS02640	COG0247	lactate metabolic process
AZL_RS02660	COG1454	alcohol dehydrogenase
AZL_RS02665	COG1960	acyl-CoA dehydrogenase activity
AZL_RS02685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AZL_RS02690	COG2171	N-acyltransferase activity
AZL_RS02720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AZL_RS02725	COG0228	four-way junction DNA binding
AZL_RS02730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AZL_RS02735	COG0336	Belongs to the RNA methyltransferase TrmD family
AZL_RS02740	COG0335	large ribosomal subunit rRNA binding
AZL_RS02745	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AZL_RS02755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AZL_RS02760	COG0706	membrane insertase activity
AZL_RS02765	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AZL_RS02775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AZL_RS02785	COG0598	Magnesium transport protein CorA
AZL_RS02790	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AZL_RS02800	COG1530	ribonuclease E activity
AZL_RS02805	COG0860	N-Acetylmuramoyl-L-alanine amidase
AZL_RS02810	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AZL_RS02830	COG1696	Membrane protein involved in D-alanine export
AZL_RS02850	COG1877	trehalose-phosphatase activity
AZL_RS02850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AZL_RS02885	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AZL_RS02890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AZL_RS02895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AZL_RS02985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AZL_RS03005	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AZL_RS03010	COG0081	regulation of translation
AZL_RS03015	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AZL_RS03020	COG0222	ribosome binding
AZL_RS03025	COG0085	RNA polymerase activity
AZL_RS03030	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AZL_RS03050	COG0049	tRNA binding
AZL_RS03060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AZL_RS03065	COG0051	transcription antitermination factor activity, RNA binding
AZL_RS03075	COG0088	Forms part of the polypeptide exit tunnel
AZL_RS03080	COG0089	rRNA binding
AZL_RS03085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AZL_RS03090	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AZL_RS03095	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AZL_RS03100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AZL_RS03105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AZL_RS03110	COG0255	Belongs to the universal ribosomal protein uL29 family
AZL_RS03115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AZL_RS03125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AZL_RS03135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AZL_RS03140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AZL_RS03145	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AZL_RS03155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AZL_RS03160	COG1841	ribosomal large subunit assembly
AZL_RS03165	COG0200	Binds to the 23S rRNA
AZL_RS03175	COG0563	adenylate kinase activity
AZL_RS03180	COG2186	Transcriptional regulator
AZL_RS03185	COG0697	spore germination
AZL_RS03200	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AZL_RS03205	COG3842	ATPase activity
AZL_RS03220	COG2873	o-acetylhomoserine
AZL_RS03230	COG2205	protein histidine kinase activity
AZL_RS03235	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AZL_RS03280	COG1285	pathogenesis
AZL_RS03285	COG2814	Major facilitator Superfamily
AZL_RS03290	COG0196	riboflavin kinase activity
AZL_RS03295	COG2030	dehydratase
AZL_RS03300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AZL_RS03305	COG2267	carboxylic ester hydrolase activity
AZL_RS03315	COG0628	permease
AZL_RS03345	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AZL_RS03350	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AZL_RS03360	COG1597	lipid kinase activity
AZL_RS03370	COG0438	transferase activity, transferring glycosyl groups
AZL_RS03380	COG1519	Transferase
AZL_RS03385	COG1663	tetraacyldisaccharide 4'-kinase activity
AZL_RS03415	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AZL_RS03420	COG0644	oxidoreductase
AZL_RS03475	COG1902	pentaerythritol trinitrate reductase activity
AZL_RS03485	COG2962	Rard protein
AZL_RS03490	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AZL_RS03500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AZL_RS03515	COG2205	protein histidine kinase activity
AZL_RS03530	COG0395	ABC-type sugar transport system, permease component
AZL_RS03535	COG3842	ATPase activity
AZL_RS03540	COG5508	conserved small protein
AZL_RS03545	COG0501	Belongs to the peptidase M48B family
AZL_RS03585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZL_RS03585	COG4191	Histidine kinase
AZL_RS03590	COG1366	Belongs to the anti-sigma-factor antagonist family
AZL_RS03615	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AZL_RS03640	COG1686	Belongs to the peptidase S11 family
AZL_RS03645	COG5002	protein histidine kinase activity
AZL_RS03645	COG2198	Histidine kinase
AZL_RS03645	COG0784	Response regulator, receiver
AZL_RS03655	COG2202	Pas domain
AZL_RS03655	COG2205	protein histidine kinase activity
AZL_RS03660	COG4191	Histidine kinase
AZL_RS03665	COG2205	protein histidine kinase activity
AZL_RS03675	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AZL_RS03685	COG0166	Belongs to the GPI family
AZL_RS03690	COG0612	Peptidase, M16
AZL_RS03695	COG0612	Peptidase, M16
AZL_RS03745	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AZL_RS03765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AZL_RS03780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AZL_RS03810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AZL_RS03815	COG0746	molybdenum cofactor guanylyltransferase activity
AZL_RS03840	COG3383	formate dehydrogenase (NAD+) activity
AZL_RS03845	COG0437	4 iron, 4 sulfur cluster binding
AZL_RS03860	COG0235	Class ii aldolase
AZL_RS03865	COG5002	protein histidine kinase activity
AZL_RS03865	COG0784	Response regulator, receiver
AZL_RS03870	COG3384	dioxygenase
AZL_RS03880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AZL_RS03885	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AZL_RS03890	COG0356	it plays a direct role in the translocation of protons across the membrane
AZL_RS03900	COG1999	signal sequence binding
AZL_RS03910	COG1702	phosphate starvation-inducible protein PhoH
AZL_RS03915	COG0850	regulation of cytokinetic process
AZL_RS03920	COG2894	cell division
AZL_RS03925	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AZL_RS03945	COG0840	transmembrane signaling receptor activity
AZL_RS03950	COG4948	Mandelate Racemase Muconate Lactonizing
AZL_RS03955	COG2154	pterin-4-alpha-carbinolamine dehydratase
AZL_RS03960	COG1573	uracil-dna glycosylase
AZL_RS03975	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AZL_RS03985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AZL_RS03995	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
AZL_RS04000	COG5420	small protein containing a coiled-coil domain
AZL_RS04015	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AZL_RS04020	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AZL_RS04065	COG0121	glutamine amidotransferase
AZL_RS04075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AZL_RS04100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AZL_RS04105	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AZL_RS04130	COG1999	signal sequence binding
AZL_RS04145	COG4771	TonB-dependent receptor
AZL_RS04155	COG1858	cytochrome C peroxidase
AZL_RS04175	COG1294	oxidase, subunit
AZL_RS04230	COG3293	Transposase
AZL_RS04265	COG0464	growth
AZL_RS04440	COG4626	Terminase
AZL_RS04440	COG1802	Transcriptional regulator
AZL_RS04625	COG0582	viral genome integration into host DNA
AZL_RS04675	COG0747	negative chemotaxis
AZL_RS04680	COG0601	transmembrane transport
AZL_RS04685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AZL_RS04690	COG0444	Belongs to the ABC transporter superfamily
AZL_RS04695	COG1124	(ABC) transporter
AZL_RS04705	COG0552	protein localization to endoplasmic reticulum
AZL_RS04710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AZL_RS04715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AZL_RS04760	COG2301	Belongs to the HpcH HpaI aldolase family
AZL_RS04765	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AZL_RS04770	COG2205	protein histidine kinase activity
AZL_RS04775	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AZL_RS04805	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AZL_RS04810	COG1063	alcohol dehydrogenase
AZL_RS04820	COG0508	dehydrogenase complex catalyzes the overall conversion of
AZL_RS04820	COG0596	Alpha beta hydrolase
AZL_RS04825	COG0022	dehydrogenase e1 component
AZL_RS04830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AZL_RS04835	COG3199	ATP-NAD kinase
AZL_RS04840	COG0277	FAD linked oxidase domain protein
AZL_RS04850	COG1671	Belongs to the UPF0178 family
AZL_RS04855	COG0488	(ABC) transporter
AZL_RS04875	COG2853	Lipoprotein
AZL_RS04885	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AZL_RS04900	COG0646	methionine synthase
AZL_RS04900	COG1410	methionine synthase
AZL_RS04925	COG3706	GGDEF domain
AZL_RS04930	COG2070	2-Nitropropane dioxygenase
AZL_RS04935	COG0488	(ABC) transporter
AZL_RS04945	COG1966	Carbon starvation protein
AZL_RS04955	COG0175	sulfate reduction
AZL_RS04960	COG0175	sulfate reduction
AZL_RS04965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AZL_RS04965	COG1648	precorrin-2 dehydrogenase activity
AZL_RS04975	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AZL_RS04985	COG3108	Peptidase M15
AZL_RS04995	COG2205	protein histidine kinase activity
AZL_RS04995	COG2202	Pas domain
AZL_RS05000	COG4566	intracellular signal transduction
AZL_RS05025	COG0243	molybdopterin cofactor binding
AZL_RS05030	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AZL_RS05030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AZL_RS05040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AZL_RS05055	COG0612	Peptidase, M16
AZL_RS05080	COG0483	inositol monophosphate 1-phosphatase activity
AZL_RS05085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AZL_RS05100	COG0730	response to heat
AZL_RS05105	COG0352	thiamine-phosphate diphosphorylase activity
AZL_RS05110	COG1830	Aldolase
AZL_RS05160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AZL_RS05165	COG1692	metallophosphoesterase
AZL_RS05170	COG0217	transcriptional regulatory protein
AZL_RS05180	COG0632	four-way junction helicase activity
AZL_RS05185	COG2255	four-way junction helicase activity
AZL_RS05190	COG0824	Thioesterase
AZL_RS05200	COG0848	biopolymer transport protein
AZL_RS05215	COG2885	chlorophyll binding
AZL_RS05225	COG0037	tRNA processing
AZL_RS05230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AZL_RS05235	COG3609	addiction module antidote protein, CC2985 family
AZL_RS05245	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AZL_RS05250	COG1295	ribonuclease BN
AZL_RS05260	COG4520	surface antigen
AZL_RS05265	COG0259	pyridoxamine-phosphate oxidase activity
AZL_RS05275	COG0840	transmembrane signaling receptor activity
AZL_RS05295	COG2153	protein acetylation
AZL_RS05310	COG3685	Protein conserved in bacteria
AZL_RS05325	COG4957	zinc ion binding
AZL_RS05330	COG0698	ribose 5-phosphate isomerase
AZL_RS05335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AZL_RS05340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AZL_RS05345	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AZL_RS05360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AZL_RS05370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AZL_RS05370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AZL_RS05380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AZL_RS05380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AZL_RS05400	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AZL_RS05405	COG0416	fatty acid biosynthetic process
AZL_RS05410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AZL_RS05415	COG0776	regulation of translation
AZL_RS05460	COG3293	Transposase
AZL_RS05520	COG1764	response to oxidative stress
AZL_RS05525	COG1846	Transcriptional regulator
AZL_RS05530	COG0456	acetyltransferase
AZL_RS05535	COG2890	protein-(glutamine-N5) methyltransferase activity
AZL_RS05540	COG1393	Belongs to the ArsC family
AZL_RS05545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AZL_RS05555	COG1403	HNH endonuclease
AZL_RS05560	COG0697	spore germination
AZL_RS05585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AZL_RS05640	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AZL_RS05645	COG3409	Peptidoglycan-binding domain 1 protein
AZL_RS05645	COG0860	N-Acetylmuramoyl-L-alanine amidase
AZL_RS05650	COG3108	Peptidase M15
AZL_RS05670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AZL_RS05675	COG0511	ligase activity, forming carbon-carbon bonds
AZL_RS05680	COG0439	Biotin carboxylase
AZL_RS05685	COG0840	transmembrane signaling receptor activity
AZL_RS05690	COG0745	RESPONSE REGULATOR receiver
AZL_RS05710	COG0432	Pfam Uncharacterised protein family UPF0047
AZL_RS05715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AZL_RS05725	COG2205	protein histidine kinase activity
AZL_RS05730	COG0628	permease
AZL_RS05740	COG0616	signal peptide processing
AZL_RS05750	COG0745	RESPONSE REGULATOR receiver
AZL_RS05765	COG0840	transmembrane signaling receptor activity
AZL_RS05770	COG0436	Aminotransferase
AZL_RS05780	COG1494	fructose-1,6-bisphosphatase
AZL_RS05800	COG0303	'Molybdopterin
AZL_RS05805	COG0583	DNA-binding transcription factor activity
AZL_RS05820	COG2373	Large extracellular alpha-helical protein
AZL_RS05825	COG4953	penicillin-binding protein 1C
AZL_RS05840	COG2132	Multicopper oxidase
AZL_RS05850	COG1914	H( )-stimulated, divalent metal cation uptake system
AZL_RS05890	COG0583	DNA-binding transcription factor activity
AZL_RS05915	COG0583	DNA-binding transcription factor activity
AZL_RS05920	COG2814	Major facilitator Superfamily
AZL_RS05945	COG3293	Transposase
AZL_RS05975	COG3239	Fatty acid desaturase
AZL_RS06015	COG4651	solute:proton antiporter activity
AZL_RS06015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AZL_RS06025	COG3932	Exopolysaccharide synthesis, ExoD
AZL_RS06090	COG2894	cell division
AZL_RS06130	COG3451	type IV secretory pathway VirB4
AZL_RS06175	COG1484	DNA-dependent DNA replication
AZL_RS06180	COG4584	PFAM Integrase catalytic
AZL_RS06195	COG0519	Catalyzes the synthesis of GMP from XMP
AZL_RS06195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AZL_RS06200	COG1247	-acetyltransferase
AZL_RS06210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AZL_RS06225	COG1758	RNA polymerase activity
AZL_RS06235	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AZL_RS06240	COG0736	holo-[acyl-carrier-protein] synthase activity
AZL_RS06245	COG0681	Belongs to the peptidase S26 family
AZL_RS06250	COG0571	ribonuclease III activity
AZL_RS06255	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AZL_RS06270	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AZL_RS06325	COG1752	Esterase of the alpha-beta hydrolase superfamily
AZL_RS06350	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AZL_RS06360	COG1338	Plays a role in the flagellum-specific transport system
AZL_RS06375	COG2257	FlhB HrpN YscU SpaS Family
AZL_RS06380	COG1815	bacterial-type flagellum-dependent cell motility
AZL_RS06385	COG1558	bacterial-type flagellum-dependent cell motility
AZL_RS06390	COG1677	Flagellar hook-basal body complex protein FliE
AZL_RS06400	COG1684	flagellar biosynthetic protein fliR
AZL_RS06405	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AZL_RS06440	COG2010	Cytochrome c
AZL_RS06455	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AZL_RS06465	COG2076	Multidrug Resistance protein
AZL_RS06470	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AZL_RS06485	COG0312	modulator of DNA gyrase
AZL_RS06495	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AZL_RS06500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AZL_RS06505	COG0109	protoheme IX farnesyltransferase activity
AZL_RS06515	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AZL_RS06520	COG1845	cytochrome c oxidase, subunit III
AZL_RS06530	COG3346	SURF1 family
AZL_RS06540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AZL_RS06545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AZL_RS06550	COG3237	CsbD-like
AZL_RS06565	COG1742	UPF0060 membrane protein
AZL_RS06575	COG5001	Diguanylate cyclase
AZL_RS06580	COG1840	ABC-type Fe3 transport system, periplasmic component
AZL_RS06585	COG3842	ATPase activity
AZL_RS06590	COG1132	(ABC) transporter
AZL_RS06595	COG1752	Esterase of the alpha-beta hydrolase superfamily
AZL_RS06615	COG1178	ABC-type Fe3 transport system permease component
AZL_RS06620	COG1217	gtp-binding protein TYPA
AZL_RS06635	COG2226	methyltransferase
AZL_RS06650	COG0739	heme binding
AZL_RS06650	COG0741	lytic transglycosylase activity
AZL_RS06650	COG1196	nuclear chromosome segregation
AZL_RS06665	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AZL_RS06670	COG1765	OsmC-like protein
AZL_RS06690	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AZL_RS06695	COG0728	peptidoglycan biosynthetic process
AZL_RS06700	COG2205	protein histidine kinase activity
AZL_RS06720	COG2086	electron transfer activity
AZL_RS06730	COG0789	Transcriptional regulator
AZL_RS06735	COG0318	PFAM AMP-dependent synthetase and ligase
AZL_RS06755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AZL_RS06760	COG1360	Flagellar Motor Protein
AZL_RS06765	COG2308	Evidence 4 Homologs of previously reported genes of
AZL_RS06790	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AZL_RS06790	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AZL_RS06810	COG0626	cystathionine gamma-synthase activity
AZL_RS06815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZL_RS06820	COG4597	amino acid ABC transporter
AZL_RS06825	COG0765	amino acid transport
AZL_RS06830	COG1126	abc transporter atp-binding protein
AZL_RS06835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AZL_RS06850	COG0454	-acetyltransferase
AZL_RS06850	COG0456	acetyltransferase
AZL_RS06855	COG2897	thiosulfate sulfurtransferase activity
AZL_RS06865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AZL_RS06870	COG0494	nUDIX hydrolase
AZL_RS06875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AZL_RS06905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AZL_RS06915	COG1538	Outer membrane efflux protein
AZL_RS06925	COG0525	valine-tRNA ligase activity
AZL_RS06930	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AZL_RS06935	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AZL_RS06945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AZL_RS06950	COG0628	permease
AZL_RS06960	COG0300	oxidoreductase activity
AZL_RS06965	COG1846	Transcriptional regulator
AZL_RS07010	COG1396	sequence-specific DNA binding
AZL_RS07095	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AZL_RS07100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AZL_RS07110	COG4191	Histidine kinase
AZL_RS07140	COG2205	protein histidine kinase activity
AZL_RS07140	COG0784	Response regulator, receiver
AZL_RS07140	COG5002	protein histidine kinase activity
AZL_RS07145	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AZL_RS07160	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AZL_RS07160	COG1618	nucleotide phosphatase activity, acting on free nucleotides
AZL_RS07170	COG1028	Short-chain dehydrogenase reductase Sdr
AZL_RS07175	COG0443	Heat shock 70 kDa protein
AZL_RS07180	COG0489	protein tyrosine kinase activity
AZL_RS07185	COG0330	HflC and HflK could
AZL_RS07190	COG0330	HflC and HflK could
AZL_RS07195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AZL_RS07200	COG2197	response regulator
AZL_RS07210	COG0745	RESPONSE REGULATOR receiver
AZL_RS07220	COG1846	Transcriptional regulator
AZL_RS07230	COG0149	triose-phosphate isomerase activity
AZL_RS07275	COG1136	(ABC) transporter
AZL_RS07280	COG0577	efflux transmembrane transporter activity
AZL_RS07280	COG1136	(ABC) transporter
AZL_RS07320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AZL_RS07395	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AZL_RS07400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AZL_RS07405	COG0534	Mate efflux family protein
AZL_RS07425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AZL_RS07430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AZL_RS07435	COG2813	Specifically methylates the guanine in position
AZL_RS07440	COG0667	Aldo Keto reductase
AZL_RS07455	COG1881	PFAM PEBP family protein
AZL_RS07460	COG5504	Zn-dependent protease
AZL_RS07465	COG0113	porphobilinogen synthase activity
AZL_RS07475	COG1597	lipid kinase activity
AZL_RS07480	COG1024	Enoyl-CoA hydratase
AZL_RS07485	COG1846	Transcriptional regulator
AZL_RS07495	COG0559	Belongs to the binding-protein-dependent transport system permease family
AZL_RS07510	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AZL_RS07535	COG1028	Short-chain dehydrogenase reductase Sdr
AZL_RS07540	COG0840	transmembrane signaling receptor activity
AZL_RS07540	COG2972	Histidine kinase
AZL_RS07560	COG0058	SHG alpha-glucan phosphorylase activity
AZL_RS07565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AZL_RS07570	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AZL_RS07585	COG1305	Transglutaminase-like
AZL_RS07590	COG2307	Protein conserved in bacteria
AZL_RS07590	COG2308	Evidence 4 Homologs of previously reported genes of
AZL_RS07645	COG3784	Protein of unknown function (DUF1318)
AZL_RS07660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AZL_RS07665	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AZL_RS07680	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AZL_RS07685	COG2814	Major facilitator Superfamily
AZL_RS07690	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AZL_RS07700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AZL_RS07715	COG1862	Preprotein translocase
AZL_RS07720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AZL_RS07730	COG3737	Protein of unknown function (DUF498/DUF598)
AZL_RS07735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AZL_RS07740	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AZL_RS07745	COG1562	ergosterol biosynthetic process
AZL_RS07750	COG1562	ergosterol biosynthetic process
AZL_RS07770	COG0583	DNA-binding transcription factor activity
AZL_RS07775	COG2814	Major facilitator Superfamily
AZL_RS07780	COG2226	methyltransferase
AZL_RS07830	COG0714	Associated with various cellular activities
AZL_RS07840	COG0494	nUDIX hydrolase
AZL_RS07845	COG0617	tRNA 3'-terminal CCA addition
AZL_RS07855	COG0248	Ppx GppA phosphatase
AZL_RS07860	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AZL_RS07875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AZL_RS07885	COG0629	single-stranded DNA binding
AZL_RS07915	COG0123	including yeast histone deacetylase and acetoin utilization protein
AZL_RS07920	COG1116	anion transmembrane transporter activity
AZL_RS07925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AZL_RS07930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AZL_RS07945	COG0483	inositol monophosphate 1-phosphatase activity
AZL_RS07960	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AZL_RS07965	COG1923	regulation of RNA biosynthetic process
AZL_RS07975	COG3744	PilT protein domain protein
AZL_RS07985	COG2204	response regulator
AZL_RS08015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AZL_RS08015	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AZL_RS08020	COG1546	Belongs to the CinA family
AZL_RS08020	COG1058	Belongs to the CinA family
AZL_RS08025	COG1942	4-Oxalocrotonate Tautomerase
AZL_RS08030	COG2867	negative regulation of translational initiation
AZL_RS08035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AZL_RS08045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AZL_RS08055	COG0508	dehydrogenase complex catalyzes the overall conversion of
AZL_RS08060	COG0508	dehydrogenase complex catalyzes the overall conversion of
AZL_RS08060	COG0022	dehydrogenase e1 component
AZL_RS08065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AZL_RS08085	COG4149	molybdate abc transporter
AZL_RS08090	COG0725	ABC transporter, periplasmic molybdate-binding protein
AZL_RS08100	COG2261	transglycosylase associated protein
AZL_RS08115	COG2135	peptidase activity
AZL_RS08125	COG2199	diguanylate cyclase activity
AZL_RS08125	COG2200	EAL domain
AZL_RS08125	COG3287	FIST C domain
AZL_RS08135	COG1218	3'(2'),5'-bisphosphate nucleotidase
AZL_RS08140	COG2833	Protein of unknown function (DUF455)
AZL_RS08145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AZL_RS08150	COG0328	RNA-DNA hybrid ribonuclease activity
AZL_RS08155	COG0678	peroxiredoxin activity
AZL_RS08160	COG2824	Alkylphosphonate utilization operon protein PhnA
AZL_RS08165	COG4232	protein-disulfide reductase activity
AZL_RS08170	COG1678	Uncharacterized ACR, COG1678
AZL_RS08175	COG0314	molybdopterin synthase activity
AZL_RS08180	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AZL_RS08190	COG0546	phosphoglycolate phosphatase activity
AZL_RS08195	COG1763	Mo-molybdopterin cofactor biosynthetic process
AZL_RS08200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AZL_RS08230	COG4120	Belongs to the binding-protein-dependent transport system permease family
AZL_RS08245	COG0672	)-iron permease
AZL_RS08270	COG0583	DNA-binding transcription factor activity
AZL_RS08275	COG0540	Belongs to the ATCase OTCase family
AZL_RS08280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AZL_RS08300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AZL_RS08315	COG0776	regulation of translation
AZL_RS08320	COG4957	zinc ion binding
AZL_RS08355	COG0741	lytic transglycosylase activity
AZL_RS08360	COG0556	nucleotide-excision repair
AZL_RS08365	COG2199	diguanylate cyclase activity
AZL_RS08365	COG2203	Gaf domain
AZL_RS08390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AZL_RS08395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AZL_RS08415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AZL_RS08420	COG1492	cobalamin metabolic process
AZL_RS08485	COG0315	cyclic pyranopterin monophosphate synthase activity
AZL_RS08490	COG0303	'Molybdopterin
AZL_RS08495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AZL_RS08500	COG0658	competence protein
AZL_RS08500	COG2333	competence protein COMEC
AZL_RS08505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AZL_RS08520	COG4977	sequence-specific DNA binding
AZL_RS08530	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AZL_RS08535	COG3494	Protein of unknown function (DUF1009)
AZL_RS08560	COG0750	zinc metalloprotease
AZL_RS08565	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AZL_RS08575	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AZL_RS08580	COG0233	cytoplasmic translational termination
AZL_RS08585	COG0528	UMP kinase activity
AZL_RS08590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AZL_RS08595	COG0052	Belongs to the universal ribosomal protein uS2 family
AZL_RS08600	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AZL_RS08605	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AZL_RS08615	COG4221	oxidoreductase activity
AZL_RS08620	COG1561	YicC-like family, N-terminal region
AZL_RS08650	COG0513	Belongs to the DEAD box helicase family
AZL_RS08660	COG0596	Alpha beta hydrolase
AZL_RS08670	COG0187	DNA topoisomerase II activity
AZL_RS08675	COG1607	acyl-coa hydrolase
AZL_RS08685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AZL_RS08690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AZL_RS08720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZL_RS08720	COG4191	Histidine kinase
AZL_RS08735	COG0784	Response regulator, receiver
AZL_RS08735	COG3437	response regulator, receiver
AZL_RS08745	COG0140	phosphoribosyl-ATP diphosphatase activity
AZL_RS08775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AZL_RS08780	COG0643	Histidine kinase
AZL_RS08780	COG2198	Histidine kinase
AZL_RS08785	COG2201	protein-glutamate methylesterase activity
AZL_RS08790	COG2201	protein-glutamate methylesterase activity
AZL_RS08805	COG0840	transmembrane signaling receptor activity
AZL_RS08810	COG0840	transmembrane signaling receptor activity
AZL_RS08825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AZL_RS08830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AZL_RS08845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AZL_RS08855	COG0360	Binds together with S18 to 16S ribosomal RNA
AZL_RS08860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AZL_RS08870	COG0359	binds to the 23S rRNA
AZL_RS08875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AZL_RS08880	COG3706	GGDEF domain
AZL_RS08885	COG0538	isocitrate dehydrogenase activity
AZL_RS08895	COG0330	HflC and HflK could
AZL_RS08920	COG0473	3-isopropylmalate dehydrogenase activity
AZL_RS08940	COG2814	Major facilitator Superfamily
AZL_RS08960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AZL_RS08970	COG4221	oxidoreductase activity
AZL_RS08975	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AZL_RS09000	COG0024	Methionine aminopeptidase
AZL_RS09020	COG1160	GTP binding
AZL_RS09035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AZL_RS09070	COG0840	transmembrane signaling receptor activity
AZL_RS09070	COG3290	protein histidine kinase activity
AZL_RS09075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AZL_RS09080	COG5433	transposase activity
AZL_RS09090	COG1749	Flagellar hook protein flgE
AZL_RS09155	COG3321	synthase
AZL_RS09155	COG1028	Short-chain dehydrogenase reductase Sdr
AZL_RS09155	COG0604	alcohol dehydrogenase
AZL_RS09165	COG0163	prenyltransferase activity
AZL_RS09170	COG0288	reversible hydration of carbon dioxide
AZL_RS09190	COG0205	6-phosphofructokinase activity
AZL_RS09205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AZL_RS09210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AZL_RS09215	COG5001	Diguanylate cyclase
AZL_RS09235	COG0114	fumarate hydratase activity
AZL_RS09260	COG2951	lytic endotransglycosylase activity
AZL_RS09285	COG3852	Histidine kinase
AZL_RS09310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AZL_RS09330	COG1366	Belongs to the anti-sigma-factor antagonist family
AZL_RS09335	COG2770	Histidine kinase
AZL_RS09335	COG2208	phosphoserine phosphatase activity
AZL_RS09360	COG2814	Major facilitator Superfamily
AZL_RS09455	COG0500	methyltransferase
AZL_RS09470	COG2885	chlorophyll binding
AZL_RS09485	COG2172	sigma factor antagonist activity
AZL_RS09510	COG0105	UTP biosynthetic process
AZL_RS09520	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AZL_RS09530	COG0488	(ABC) transporter
AZL_RS09535	COG3932	Exopolysaccharide synthesis, ExoD
AZL_RS09560	COG1686	Belongs to the peptidase S11 family
AZL_RS09565	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AZL_RS09570	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AZL_RS09575	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AZL_RS09580	COG0084	hydrolase, TatD family'
AZL_RS09585	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AZL_RS09585	COG0321	lipoyl(octanoyl) transferase activity
AZL_RS09590	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AZL_RS09615	COG5001	Diguanylate cyclase
AZL_RS09620	COG1381	Involved in DNA repair and RecF pathway recombination
AZL_RS09625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AZL_RS09655	COG4786	Flagellar basal body rod
AZL_RS09660	COG4786	Flagellar basal body rod
AZL_RS09670	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AZL_RS09730	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AZL_RS09740	COG1024	Enoyl-CoA hydratase
AZL_RS09750	COG0758	DNA mediated transformation
AZL_RS09755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AZL_RS09760	COG1024	Enoyl-CoA hydratase
AZL_RS09765	COG1832	CoA-binding protein
AZL_RS09780	COG1028	Short-chain dehydrogenase reductase Sdr
AZL_RS09785	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AZL_RS09805	COG2207	Transcriptional regulator
AZL_RS09820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AZL_RS09840	COG5002	protein histidine kinase activity
AZL_RS09840	COG3447	MASE1 domain protein
AZL_RS09840	COG5001	Diguanylate cyclase
AZL_RS09860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AZL_RS09875	COG1238	metal cluster binding
AZL_RS09880	COG0203	ribosomal protein L17
AZL_RS09895	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AZL_RS09905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AZL_RS09910	COG0251	oxidation-reduction process
AZL_RS09990	COG3293	Transposase
AZL_RS10010	COG3415	Transposase
AZL_RS10015	COG3335	DDE superfamily endonuclease
AZL_RS10125	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AZL_RS10125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AZL_RS10165	COG0154	amidase activity
AZL_RS10170	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AZL_RS10185	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AZL_RS10195	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AZL_RS10205	COG3070	regulator of competence-specific genes
AZL_RS10215	COG0242	peptide deformylase activity
AZL_RS10220	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AZL_RS10225	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AZL_RS10230	COG1201	RNA secondary structure unwinding
AZL_RS10240	COG0415	Belongs to the DNA photolyase family
AZL_RS10245	COG0735	belongs to the Fur family
AZL_RS10250	COG0523	cobalamin synthesis protein
AZL_RS10260	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AZL_RS10275	COG2205	protein histidine kinase activity
AZL_RS10285	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AZL_RS10290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AZL_RS10290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AZL_RS10315	COG0494	nUDIX hydrolase
AZL_RS10325	COG0497	DNA recombination
AZL_RS10330	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AZL_RS10350	COG0006	proline dipeptidase activity
AZL_RS10360	COG2264	protein methyltransferase activity
AZL_RS10370	COG0210	DNA helicase
AZL_RS10375	COG2197	response regulator
AZL_RS10380	COG2197	response regulator
AZL_RS10410	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AZL_RS10420	COG2910	NAD(P)H-binding
AZL_RS10440	COG0742	ribosomal rna small subunit methyltransferase
AZL_RS10445	COG1187	pseudouridine synthase activity
AZL_RS10450	COG0590	tRNA wobble adenosine to inosine editing
AZL_RS10475	COG0859	PFAM glycosyl transferase family 9
AZL_RS10475	COG0457	Tetratricopeptide repeat
AZL_RS10480	COG0418	dihydroorotase activity
AZL_RS10505	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AZL_RS10510	COG0193	aminoacyl-tRNA hydrolase activity
AZL_RS10530	COG0012	GTP binding
AZL_RS10535	COG3300	MHYT domain
AZL_RS10535	COG5001	Diguanylate cyclase
AZL_RS10545	COG0583	DNA-binding transcription factor activity
AZL_RS10575	COG2945	thiolester hydrolase activity
AZL_RS10580	COG1045	serine acetyltransferase
AZL_RS10590	COG1104	cysteine desulfurase activity
AZL_RS10605	COG0482	sulfurtransferase activity
AZL_RS10805	COG1802	Transcriptional regulator
AZL_RS10805	COG4626	Terminase
AZL_RS10980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AZL_RS10990	COG0531	amino acid
AZL_RS10995	COG3706	GGDEF domain
AZL_RS11000	COG3284	Transcriptional regulator
AZL_RS11025	COG0488	(ABC) transporter
AZL_RS11035	COG3023	N-Acetylmuramoyl-L-alanine amidase
AZL_RS11040	COG2001	Belongs to the MraZ family
AZL_RS11045	COG0275	rRNA processing
AZL_RS11060	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AZL_RS11070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AZL_RS11075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AZL_RS11085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AZL_RS11095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AZL_RS11100	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AZL_RS11105	COG1181	Belongs to the D-alanine--D-alanine ligase family
AZL_RS11110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AZL_RS11115	COG0849	cell division
AZL_RS11120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AZL_RS11135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AZL_RS11155	COG0248	Ppx GppA phosphatase
AZL_RS11160	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AZL_RS11165	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AZL_RS11180	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AZL_RS11235	COG1079	Belongs to the binding-protein-dependent transport system permease family
AZL_RS11240	COG4603	Belongs to the binding-protein-dependent transport system permease family
AZL_RS11245	COG3845	ABC transporter
AZL_RS11250	COG0354	folic acid binding
AZL_RS11265	COG0546	phosphoglycolate phosphatase activity
AZL_RS11270	COG0564	pseudouridine synthase activity
AZL_RS11275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AZL_RS11290	COG1136	(ABC) transporter
AZL_RS11310	COG0442	prolyl-tRNA aminoacylation
AZL_RS11330	COG0519	Catalyzes the synthesis of GMP from XMP
AZL_RS11340	COG0346	lactoylglutathione lyase activity
AZL_RS11360	COG1007	ATP synthesis coupled electron transport
AZL_RS11375	COG0713	ATP synthesis coupled electron transport
AZL_RS11390	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AZL_RS11395	COG1034	ATP synthesis coupled electron transport
AZL_RS11410	COG0649	NAD binding
AZL_RS11415	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AZL_RS11420	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AZL_RS11425	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AZL_RS11480	COG0583	DNA-binding transcription factor activity
AZL_RS11505	COG0500	methyltransferase
AZL_RS11510	COG0140	phosphoribosyl-ATP diphosphatase activity
AZL_RS11520	COG2862	Uncharacterized protein family, UPF0114
AZL_RS11540	COG0768	penicillin binding
AZL_RS11550	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AZL_RS11570	COG0028	Belongs to the TPP enzyme family
AZL_RS11575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AZL_RS11580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AZL_RS11585	COG0560	Phosphoserine phosphatase
AZL_RS11595	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AZL_RS11610	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AZL_RS11615	COG0830	nickel cation binding
AZL_RS11620	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AZL_RS11625	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AZL_RS11630	COG0804	urea catabolic process
AZL_RS11635	COG0832	Belongs to the urease beta subunit family
AZL_RS11640	COG0831	urea catabolic process
AZL_RS11645	COG0829	nickel cation binding
AZL_RS11650	COG2197	response regulator
AZL_RS11655	COG2197	response regulator
AZL_RS11660	COG0693	protein deglycase activity
AZL_RS11675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AZL_RS11680	COG0717	Belongs to the dCTP deaminase family
AZL_RS11790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AZL_RS11825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AZL_RS11835	COG0557	exoribonuclease II activity
AZL_RS11840	COG0793	Belongs to the peptidase S41A family
AZL_RS11845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AZL_RS11860	COG1380	Effector of murein hydrolase LrgA
AZL_RS11865	COG1346	cytolysis
AZL_RS11870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AZL_RS11890	COG1496	oxidoreductase activity
AZL_RS11895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AZL_RS11925	COG4191	Histidine kinase
AZL_RS11925	COG0784	Response regulator, receiver
AZL_RS11940	COG1131	(ABC) transporter
AZL_RS11965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AZL_RS11980	COG5554	nitrogen fixation
AZL_RS12005	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AZL_RS12020	COG2917	probably involved in intracellular septation
AZL_RS12025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AZL_RS12035	COG0745	RESPONSE REGULATOR receiver
AZL_RS12040	COG2176	DNA-directed DNA polymerase activity
AZL_RS12040	COG5002	protein histidine kinase activity
AZL_RS12050	COG2204	response regulator
AZL_RS12055	COG3852	Histidine kinase
AZL_RS12060	COG2204	response regulator
AZL_RS12065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AZL_RS12120	COG0752	glycyl-tRNA synthetase alpha subunit
AZL_RS12125	COG0751	glycine-tRNA ligase activity
AZL_RS12155	COG3437	response regulator, receiver
AZL_RS12155	COG2770	Histidine kinase
AZL_RS12160	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AZL_RS12170	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AZL_RS12175	COG0047	phosphoribosylformylglycinamidine synthase activity
AZL_RS12180	COG0004	ammonium transporteR
AZL_RS12185	COG0312	modulator of DNA gyrase
AZL_RS12205	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AZL_RS12235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AZL_RS12245	COG0463	Glycosyl transferase, family 2
AZL_RS12270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AZL_RS12280	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
AZL_RS12285	COG3118	belongs to the thioredoxin family
AZL_RS12295	COG2835	tetraacyldisaccharide 4'-kinase activity
AZL_RS12305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AZL_RS12315	COG0183	Belongs to the thiolase family
AZL_RS12320	COG3243	poly(R)-hydroxyalkanoic acid synthase
AZL_RS12325	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AZL_RS12360	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
AZL_RS12365	COG0842	Transport permease protein
AZL_RS12370	COG1132	(ABC) transporter
AZL_RS12375	COG0254	rRNA binding
AZL_RS12385	COG0071	Belongs to the small heat shock protein (HSP20) family
AZL_RS12400	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AZL_RS12405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AZL_RS12410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AZL_RS12420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AZL_RS12430	COG0793	Belongs to the peptidase S41A family
AZL_RS12435	COG4942	peptidase
AZL_RS12440	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AZL_RS12445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AZL_RS12450	COG0799	negative regulation of ribosome biogenesis
AZL_RS12455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AZL_RS12470	COG1051	belongs to the nudix hydrolase family
AZL_RS12480	COG0745	RESPONSE REGULATOR receiver
AZL_RS12485	COG2198	Histidine kinase
AZL_RS12485	COG0643	Histidine kinase
AZL_RS12490	COG0835	chemotaxis
AZL_RS12495	COG0840	transmembrane signaling receptor activity
AZL_RS12495	COG2972	Histidine kinase
AZL_RS12505	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AZL_RS12510	COG2201	protein-glutamate methylesterase activity
AZL_RS12515	COG0840	transmembrane signaling receptor activity
AZL_RS12520	COG1366	Belongs to the anti-sigma-factor antagonist family
AZL_RS12545	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AZL_RS12550	COG5433	transposase activity
AZL_RS12555	COG0579	oxidoreductase
AZL_RS12560	COG0071	Belongs to the small heat shock protein (HSP20) family
AZL_RS12590	COG1322	Protein conserved in bacteria
AZL_RS12605	COG1028	Short-chain dehydrogenase reductase Sdr
AZL_RS12610	COG0436	Aminotransferase
AZL_RS12655	COG1278	Cold shock
AZL_RS12685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AZL_RS12690	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AZL_RS12705	COG2193	ferroxidase activity
AZL_RS12715	COG1192	Involved in chromosome partitioning
AZL_RS12720	COG0009	L-threonylcarbamoyladenylate synthase
AZL_RS12735	COG0277	FAD linked oxidase domain protein
AZL_RS12740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AZL_RS12755	COG5433	transposase activity
AZL_RS12765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AZL_RS12770	COG0747	negative chemotaxis
AZL_RS12790	COG0101	tRNA pseudouridine synthase activity
AZL_RS12795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AZL_RS12800	COG0242	peptide deformylase activity
AZL_RS12805	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AZL_RS12820	COG0513	Belongs to the DEAD box helicase family
AZL_RS12830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AZL_RS12835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AZL_RS12835	COG1199	ATP-dependent helicase activity
AZL_RS12865	COG1879	ABC-type sugar transport system periplasmic component
AZL_RS12870	COG0679	Auxin Efflux Carrier
AZL_RS12880	COG2084	Dehydrogenase
AZL_RS12885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AZL_RS12900	COG1595	DNA-templated transcription, initiation
AZL_RS12915	COG4251	negative regulation of phosphorylation
AZL_RS12915	COG5001	Diguanylate cyclase
AZL_RS12915	COG2203	Gaf domain
AZL_RS12915	COG3706	GGDEF domain
AZL_RS12920	COG2205	protein histidine kinase activity
AZL_RS12920	COG5002	protein histidine kinase activity
AZL_RS12920	COG0784	Response regulator, receiver
AZL_RS12935	COG3279	Response regulator of the LytR AlgR family
AZL_RS12960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AZL_RS12975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AZL_RS12990	COG2350	Protein conserved in bacteria
AZL_RS12995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AZL_RS13010	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AZL_RS13015	COG2205	protein histidine kinase activity
AZL_RS13025	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AZL_RS13035	COG0586	Pfam SNARE associated Golgi protein
AZL_RS13050	COG1278	Cold shock
AZL_RS13105	COG3327	negative regulation of DNA-templated transcription, initiation
AZL_RS13115	COG2871	sodium ion transport
AZL_RS13130	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AZL_RS13160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AZL_RS13165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AZL_RS13175	COG0167	dihydroorotate dehydrogenase activity
AZL_RS13240	COG2032	superoxide dismutase activity
AZL_RS13245	COG0513	Belongs to the DEAD box helicase family
AZL_RS13250	COG0625	glutathione transferase activity
AZL_RS13270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AZL_RS13280	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AZL_RS13300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AZL_RS13310	COG4974	Belongs to the 'phage' integrase family
AZL_RS13315	COG0840	transmembrane signaling receptor activity
AZL_RS13320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AZL_RS13335	COG3012	SEC-C Motif Domain Protein
AZL_RS13345	COG4191	Histidine kinase
AZL_RS13365	COG0126	phosphoglycerate kinase activity
AZL_RS13380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AZL_RS13385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AZL_RS13390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AZL_RS13405	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AZL_RS13420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AZL_RS13425	COG0582	viral genome integration into host DNA
AZL_RS13430	COG3311	Transcriptional regulator
AZL_RS13440	COG4584	PFAM Integrase catalytic
AZL_RS13445	COG1484	DNA-dependent DNA replication
AZL_RS13450	COG3335	DDE superfamily endonuclease
AZL_RS13455	COG3415	Transposase
AZL_RS13470	COG1546	Belongs to the CinA family
AZL_RS13470	COG1058	Belongs to the CinA family
AZL_RS13475	COG1489	DNA binding
AZL_RS13480	COG0024	Methionine aminopeptidase
AZL_RS13655	COG0514	ATP-dependent DNA helicase (RecQ)
AZL_RS13660	COG0494	nUDIX hydrolase
AZL_RS13670	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AZL_RS13675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AZL_RS13680	COG0653	protein targeting
AZL_RS13685	COG1970	mechanosensitive ion channel activity
AZL_RS13700	COG0640	Transcriptional regulator
AZL_RS13740	COG0039	L-malate dehydrogenase activity
AZL_RS13745	COG0045	succinate-CoA ligase (ADP-forming) activity
AZL_RS13770	COG3293	Transposase
AZL_RS13780	COG4191	Histidine kinase
AZL_RS13795	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AZL_RS13810	COG1643	Atp-dependent helicase
AZL_RS13815	COG1252	NADH dehydrogenase
AZL_RS13820	COG1309	transcriptional regulator
AZL_RS13825	COG0481	GTPase activity
AZL_RS13840	COG0252	asparaginase activity
AZL_RS13850	COG0583	DNA-binding transcription factor activity
AZL_RS13860	COG3437	response regulator, receiver
AZL_RS13860	COG0784	Response regulator, receiver
AZL_RS13875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AZL_RS13880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AZL_RS13885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AZL_RS13895	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AZL_RS13905	COG1187	pseudouridine synthase activity
AZL_RS13910	COG1960	acyl-CoA dehydrogenase activity
AZL_RS13925	COG0318	PFAM AMP-dependent synthetase and ligase
AZL_RS13940	COG0306	phosphate transporter
AZL_RS13945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AZL_RS13955	COG2205	protein histidine kinase activity
AZL_RS13955	COG2202	Pas domain
AZL_RS13980	COG0584	glycerophosphoryl diester phosphodiesterase
AZL_RS13985	COG1509	lysine 2,3-aminomutase activity
AZL_RS14055	COG0745	RESPONSE REGULATOR receiver
AZL_RS14065	COG1234	tRNA 3'-trailer cleavage
AZL_RS14090	COG1120	ATPase activity
AZL_RS14095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AZL_RS14120	COG0438	transferase activity, transferring glycosyl groups
AZL_RS14150	COG0492	ferredoxin-NADP+ reductase activity
AZL_RS14155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AZL_RS14170	COG2264	protein methyltransferase activity
AZL_RS14200	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AZL_RS14225	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AZL_RS14235	COG3842	ATPase activity
AZL_RS14240	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AZL_RS14245	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AZL_RS14250	COG0268	Binds directly to 16S ribosomal RNA
AZL_RS14255	COG1024	Enoyl-CoA hydratase
AZL_RS14265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AZL_RS14280	COG0477	Major facilitator Superfamily
AZL_RS14305	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AZL_RS14315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AZL_RS14325	COG0747	negative chemotaxis
AZL_RS14330	COG4166	transmembrane transport
AZL_RS14335	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AZL_RS14350	COG0039	L-malate dehydrogenase activity
AZL_RS14370	COG0598	Magnesium transport protein CorA
AZL_RS14375	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AZL_RS14380	COG1872	DUF167
AZL_RS14405	COG3415	Transposase
AZL_RS14410	COG3335	DDE superfamily endonuclease
AZL_RS14420	COG1715	Restriction endonuclease
AZL_RS14440	COG0285	dihydrofolate synthase activity
AZL_RS14445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AZL_RS14455	COG0133	tryptophan synthase activity
AZL_RS14465	COG1278	Cold shock
AZL_RS14470	COG2204	response regulator
AZL_RS14475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AZL_RS14485	COG5002	protein histidine kinase activity
AZL_RS14485	COG0784	Response regulator, receiver
AZL_RS14485	COG2205	protein histidine kinase activity
AZL_RS14490	COG2205	protein histidine kinase activity
AZL_RS14505	COG0802	atpase or kinase
AZL_RS14515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AZL_RS14520	COG2887	Belongs to the helicase family. UvrD subfamily
AZL_RS14525	COG1074	ATP-dependent DNA helicase activity
AZL_RS14530	COG3118	belongs to the thioredoxin family
AZL_RS14555	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AZL_RS14575	COG0154	amidase activity
AZL_RS14590	COG3541	Predicted nucleotidyltransferase
AZL_RS14625	COG1074	ATP-dependent DNA helicase activity
AZL_RS14635	COG1468	defense response to virus
AZL_RS14635	COG1518	maintenance of DNA repeat elements
AZL_RS14640	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AZL_RS14660	COG1484	DNA-dependent DNA replication
AZL_RS14665	COG4584	PFAM Integrase catalytic
AZL_RS14670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AZL_RS14675	COG3436	PFAM IS66 Orf2 family protein
AZL_RS14680	COG4372	Transposase
AZL_RS14695	COG4644	lycopene metabolic process
AZL_RS14715	COG0798	PFAM Bile acid sodium symporter
AZL_RS14720	COG0431	NADPH-dependent FMN reductase
AZL_RS14730	COG3335	DDE superfamily endonuclease
AZL_RS14735	COG3415	Transposase
AZL_RS14740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AZL_RS14800	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AZL_RS14840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AZL_RS14845	COG3436	PFAM IS66 Orf2 family protein
AZL_RS14850	COG4372	Transposase
AZL_RS14855	COG4372	Transposase
AZL_RS14860	COG3415	Transposase
AZL_RS14865	COG3335	DDE superfamily endonuclease
AZL_RS14870	COG4372	Transposase
AZL_RS14875	COG4584	PFAM Integrase catalytic
AZL_RS14880	COG1484	DNA-dependent DNA replication
AZL_RS14930	COG0739	heme binding
AZL_RS14950	COG0386	Belongs to the glutathione peroxidase family
AZL_RS14955	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AZL_RS14960	COG4133	protoheme IX ABC transporter activity
AZL_RS14995	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AZL_RS15000	COG0792	nuclease activity
AZL_RS15025	COG0180	Tryptophanyl-tRNA synthetase
AZL_RS15030	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AZL_RS15045	COG0840	transmembrane signaling receptor activity
AZL_RS15050	COG4771	TonB-dependent receptor
AZL_RS15065	COG0606	chelatase, subunit chli
AZL_RS15075	COG2391	methyltransferase activity
AZL_RS15110	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AZL_RS15125	COG0730	response to heat
AZL_RS15140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AZL_RS15155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AZL_RS15175	COG0668	transmembrane transport
AZL_RS15180	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AZL_RS15190	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AZL_RS15195	COG0302	gtp cyclohydrolase
AZL_RS15200	COG2967	ApaG domain
AZL_RS15210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AZL_RS15215	COG1702	phosphate starvation-inducible protein PhoH
AZL_RS15225	COG1253	flavin adenine dinucleotide binding
AZL_RS15230	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AZL_RS15235	COG1396	sequence-specific DNA binding
AZL_RS15240	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AZL_RS15245	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AZL_RS15250	COG2329	Antibiotic biosynthesis monooxygenase
AZL_RS15255	COG0779	Required for maturation of 30S ribosomal subunits
AZL_RS15280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AZL_RS15285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AZL_RS15290	COG1185	polyribonucleotide nucleotidyltransferase activity
AZL_RS15305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AZL_RS15315	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AZL_RS15320	COG1138	Cytochrome C-type biogenesis protein
AZL_RS15325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AZL_RS15330	COG3088	subunit of a heme lyase
AZL_RS15335	COG4235	cytochrome complex assembly
AZL_RS15340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AZL_RS15400	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AZL_RS15405	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AZL_RS15410	COG4395	Tim44
AZL_RS15420	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AZL_RS15425	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AZL_RS15430	COG1981	membrane
AZL_RS15510	COG0280	phosphate acetyltransferase
AZL_RS15510	COG0281	malic enzyme
AZL_RS15665	COG1484	DNA-dependent DNA replication
AZL_RS15715	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AZL_RS15760	COG1660	Displays ATPase and GTPase activities
AZL_RS15935	COG0517	IMP dehydrogenase activity
AZL_RS15935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AZL_RS16875	COG2313	pseudouridylate synthase activity
AZL_RS16930	COG0156	8-amino-7-oxononanoate synthase activity
AZL_RS16975	COG0840	transmembrane signaling receptor activity
AZL_RS17010	COG3278	Belongs to the heme-copper respiratory oxidase family
AZL_RS17280	COG1442	glycosyl transferase family 8
AZL_RS17280	COG1216	Glycosyl transferase, family 2
AZL_RS17365	COG3158	transport of potassium into the cell
AZL_RS17515	COG2719	SpoVR family
AZL_RS17520	COG2719	SpoVR family
AZL_RS18185	COG0085	RNA polymerase activity
AZL_RS18830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AZL_RS18840	COG0356	it plays a direct role in the translocation of protons across the membrane
AZL_RS19065	COG1858	cytochrome C peroxidase
AZL_RS19470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AZL_RS19490	COG0552	protein localization to endoplasmic reticulum
AZL_RS19790	COG0483	inositol monophosphate 1-phosphatase activity
AZL_RS20180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AZL_RS20215	COG0358	DNA primase activity
AZL_RS20420	COG0436	Aminotransferase
AZL_RS20695	COG2205	protein histidine kinase activity
AZL_RS21460	COG5002	protein histidine kinase activity
AZL_RS22920	COG0297	glycogen (starch) synthase activity
AZL_RS23205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AZL_RS23440	COG3158	transport of potassium into the cell
AZL_RS23460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AZL_RS23605	COG0318	PFAM AMP-dependent synthetase and ligase
AZL_RS23855	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AZL_RS24070	COG1530	ribonuclease E activity
AZL_RS24100	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AZL_RS24105	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AZL_RS24190	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AZL_RS24615	COG0445	tRNA wobble uridine modification
AZL_RS24740	COG0443	Heat shock 70 kDa protein
AZL_RS24945	COG4974	Belongs to the 'phage' integrase family
AZL_RS25045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AZL_RS25045	COG0517	IMP dehydrogenase activity
AZL_RS25415	COG5001	Diguanylate cyclase
AZL_RS25415	COG3300	MHYT domain
AZL_RS25675	COG0477	Major facilitator Superfamily
AZL_RS25830	COG0243	molybdopterin cofactor binding
AZL_RS25945	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AZL_RS26185	COG2217	Heavy metal translocating P-type atpase
AZL_RS26310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AZL_RS26350	COG2202	Pas domain
AZL_RS26350	COG2205	protein histidine kinase activity
AZL_RS26430	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AZL_RS26435	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AZL_RS26505	COG0587	DNA-directed DNA polymerase activity
AZL_RS26575	COG2137	regulation of response to DNA damage stimulus
AZL_RS26605	COG4239	(ABC) transporter, permease
AZL_RS26625	COG4166	transmembrane transport
AZL_RS26685	COG2719	SpoVR family
AZL_RS26880	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AZL_RS27105	COG1940	carbohydrate kinase activity
AZL_RS27315	COG0697	spore germination
AZL_RS27480	COG1136	(ABC) transporter
AZL_RS28155	COG1473	amidohydrolase
AZL_RS28210	COG1053	succinate dehydrogenase
AZL_RS28530	COG1024	Enoyl-CoA hydratase
AZL_RS28660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AZL_RS28990	COG1793	dna ligase
AZL_RS29070	COG0840	transmembrane signaling receptor activity
AZL_RS29155	COG1612	heme a metabolic process
AZL_RS29280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AZL_RS29370	COG1442	glycosyl transferase family 8
AZL_RS29370	COG1216	Glycosyl transferase, family 2
AZL_RS29405	COG0587	DNA-directed DNA polymerase activity
AZL_RS29500	COG4166	transmembrane transport
AZL_RS29685	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AZL_RS29820	COG0247	lactate metabolic process
AZL_RS30060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AZL_RS30075	COG1331	Highly conserved protein containing a thioredoxin domain
AZL_RS30505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AZL_RS30875	COG5001	Diguanylate cyclase
AZL_RS30875	COG3300	MHYT domain
AZL_RS31000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AZL_RS31005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AZL_RS31375	COG0837	glucose binding
AZL_RS31375	COG1737	Transcriptional regulator
AZL_RS31790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AZL_RS32050	COG4166	transmembrane transport
AZL_RS32095	COG2719	SpoVR family
AZL_RS32290	COG0445	tRNA wobble uridine modification
AZL_RS33255	COG0741	lytic transglycosylase activity
AZL_RS33255	COG1196	nuclear chromosome segregation
AZL_RS33255	COG0739	heme binding
AZL_RS33260	COG0740	serine-type endopeptidase activity
AZL_RS33285	COG1396	sequence-specific DNA binding
AZL_RS33345	COG0745	RESPONSE REGULATOR receiver
AZL_RS33365	COG2197	response regulator
AZL_RS33380	COG0740	serine-type endopeptidase activity
AZL_RS33385	COG1196	nuclear chromosome segregation
AZL_RS33385	COG0741	lytic transglycosylase activity
AZL_RS33385	COG0739	heme binding
AZL_RS33465	COG2226	methyltransferase