locus-tag	class	description
E6C67_RS00010	COG0683	leucine binding
E6C67_RS00015	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E6C67_RS00020	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E6C67_RS00025	COG0183	Belongs to the thiolase family
E6C67_RS00035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E6C67_RS00040	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E6C67_RS00050	COG3485	protocatechuate 3,4-dioxygenase
E6C67_RS00055	COG3485	protocatechuate 3,4-dioxygenase
E6C67_RS00065	COG0840	transmembrane signaling receptor activity
E6C67_RS00070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_RS00075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_RS00085	COG3265	gluconokinase activity
E6C67_RS00090	COG1609	Transcriptional regulator
E6C67_RS00095	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E6C67_RS00100	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E6C67_RS00110	COG1129	ABC transporter
E6C67_RS00110	COG0842	Transport permease protein
E6C67_RS00115	COG0842	Transport permease protein
E6C67_RS00125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E6C67_RS00135	COG0564	pseudouridine synthase activity
E6C67_RS00190	COG1566	PFAM secretion protein HlyD family protein
E6C67_RS00200	COG0129	dihydroxy-acid dehydratase activity
E6C67_RS00205	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E6C67_RS00205	COG1672	PFAM Archaeal ATPase
E6C67_RS00240	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS00245	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E6C67_RS00250	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E6C67_RS00255	COG2610	gluconate transmembrane transporter activity
E6C67_RS00260	COG2217	Heavy metal translocating P-type atpase
E6C67_RS00280	COG2884	Cell division ATP-binding protein ftsE
E6C67_RS00285	COG0204	Acyl-transferase
E6C67_RS00285	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS00335	COG2814	Major facilitator Superfamily
E6C67_RS00340	COG0667	Aldo Keto reductase
E6C67_RS00380	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
E6C67_RS00405	COG0588	phosphoglycerate mutase activity
E6C67_RS00410	COG0438	transferase activity, transferring glycosyl groups
E6C67_RS00425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C67_RS00430	COG0601	transmembrane transport
E6C67_RS00445	COG1132	(ABC) transporter
E6C67_RS00455	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E6C67_RS00490	COG1960	acyl-CoA dehydrogenase activity
E6C67_RS00505	COG1192	Involved in chromosome partitioning
E6C67_RS00515	COG1902	pentaerythritol trinitrate reductase activity
E6C67_RS00520	COG3385	transposase activity
E6C67_RS00525	COG0667	Aldo Keto reductase
E6C67_RS00555	COG0454	-acetyltransferase
E6C67_RS00565	COG0564	pseudouridine synthase activity
E6C67_RS00615	COG0840	transmembrane signaling receptor activity
E6C67_RS00615	COG2972	Histidine kinase
E6C67_RS00650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C67_RS00655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C67_RS00675	COG4774	siderophore transport
E6C67_RS00695	COG4585	Histidine kinase
E6C67_RS00785	COG0686	Belongs to the AlaDH PNT family
E6C67_RS00795	COG1522	sequence-specific DNA binding
E6C67_RS00800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E6C67_RS00805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E6C67_RS00815	COG3547	Transposase (IS116 IS110 IS902 family)
E6C67_RS00840	COG2205	protein histidine kinase activity
E6C67_RS00840	COG2198	Histidine kinase
E6C67_RS00840	COG0784	Response regulator, receiver
E6C67_RS00870	COG0306	phosphate transporter
E6C67_RS00880	COG2202	Pas domain
E6C67_RS00880	COG2205	protein histidine kinase activity
E6C67_RS00895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E6C67_RS00940	COG0405	Gamma-glutamyltransferase
E6C67_RS00985	COG2814	Major facilitator Superfamily
E6C67_RS01000	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E6C67_RS01015	COG2084	Dehydrogenase
E6C67_RS01020	COG3622	Belongs to the hyi family
E6C67_RS01025	COG0446	pyridine nucleotide-disulphide oxidoreductase
E6C67_RS01025	COG1902	pentaerythritol trinitrate reductase activity
E6C67_RS01030	COG1802	Transcriptional regulator
E6C67_RS01035	COG0673	inositol 2-dehydrogenase activity
E6C67_RS01040	COG0861	Integral membrane protein TerC family
E6C67_RS01045	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_RS01055	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_RS01070	COG1309	transcriptional regulator
E6C67_RS01105	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS01110	COG1309	transcriptional regulator
E6C67_RS01115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E6C67_RS01125	COG2721	sulfolactate sulfo-lyase activity
E6C67_RS01130	COG1904	glucuronate isomerase
E6C67_RS01135	COG1802	Transcriptional regulator
E6C67_RS01140	COG1917	Cupin 2, conserved barrel domain protein
E6C67_RS01145	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS01150	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
E6C67_RS01155	COG1803	Methylglyoxal synthase
E6C67_RS01160	COG1802	Transcriptional regulator
E6C67_RS01170	COG2274	protein secretion by the type I secretion system
E6C67_RS01175	COG2274	protein secretion by the type I secretion system
E6C67_RS01190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_RS01195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_RS01200	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E6C67_RS01215	COG0183	Belongs to the thiolase family
E6C67_RS01220	COG2050	protein possibly involved in aromatic compounds catabolism
E6C67_RS01225	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C67_RS01230	COG1024	Enoyl-CoA hydratase
E6C67_RS01235	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_RS01240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E6C67_RS01245	COG2151	metal-sulfur cluster biosynthetic enzyme
E6C67_RS01250	COG3396	Phenylacetate-CoA oxygenase
E6C67_RS01255	COG3460	Phenylacetate-CoA oxygenase
E6C67_RS01260	COG3396	Phenylacetate-CoA oxygenase
E6C67_RS01270	COG0693	protein deglycase activity
E6C67_RS01275	COG2224	Isocitrate lyase
E6C67_RS01280	COG3800	Transcriptional regulator
E6C67_RS01280	COG1396	sequence-specific DNA binding
E6C67_RS01300	COG1280	lysine exporter protein (LysE YggA)
E6C67_RS01305	COG0784	Response regulator, receiver
E6C67_RS01305	COG3437	response regulator, receiver
E6C67_RS01310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E6C67_RS01320	COG1121	(ABC) transporter
E6C67_RS01325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E6C67_RS01335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E6C67_RS01345	COG0347	Belongs to the P(II) protein family
E6C67_RS01350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E6C67_RS01395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C67_RS01405	COG2205	protein histidine kinase activity
E6C67_RS01405	COG2198	Histidine kinase
E6C67_RS01405	COG0784	Response regulator, receiver
E6C67_RS01415	COG1764	response to oxidative stress
E6C67_RS01420	COG0019	diaminopimelate decarboxylase activity
E6C67_RS01435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E6C67_RS01440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C67_RS01440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E6C67_RS01450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E6C67_RS01460	COG1131	(ABC) transporter
E6C67_RS01485	COG0489	protein tyrosine kinase activity
E6C67_RS01485	COG3206	protein involved in exopolysaccharide biosynthesis
E6C67_RS01495	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E6C67_RS01510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C67_RS01525	COG0438	transferase activity, transferring glycosyl groups
E6C67_RS01530	COG1522	sequence-specific DNA binding
E6C67_RS01545	COG0628	permease
E6C67_RS01610	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E6C67_RS01620	COG3012	SEC-C Motif Domain Protein
E6C67_RS01625	COG1278	Cold shock
E6C67_RS01630	COG2205	protein histidine kinase activity
E6C67_RS01630	COG2202	Pas domain
E6C67_RS01665	COG0583	DNA-binding transcription factor activity
E6C67_RS01680	COG3845	ABC transporter
E6C67_RS01685	COG1744	ABC transporter substrate-binding protein PnrA-like
E6C67_RS01715	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS01775	COG2099	Precorrin-6x reductase
E6C67_RS01805	COG1797	cobyrinic acid a,c-diamide synthase activity
E6C67_RS01820	COG0643	Histidine kinase
E6C67_RS01820	COG2198	Histidine kinase
E6C67_RS01830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E6C67_RS01840	COG2201	protein-glutamate methylesterase activity
E6C67_RS01845	COG0835	chemotaxis
E6C67_RS01850	COG0840	transmembrane signaling receptor activity
E6C67_RS01855	COG1776	CheC inhibitor of MCP methylation
E6C67_RS01855	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C67_RS01860	COG2201	protein-glutamate methylesterase activity
E6C67_RS01865	COG0457	Tetratricopeptide repeat
E6C67_RS01865	COG0859	PFAM glycosyl transferase family 9
E6C67_RS01870	COG1464	Belongs to the NlpA lipoprotein family
E6C67_RS01875	COG2011	ABC-type metal ion transport system permease component
E6C67_RS01885	COG1464	Belongs to the NlpA lipoprotein family
E6C67_RS01900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E6C67_RS01910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E6C67_RS01935	COG1530	ribonuclease E activity
E6C67_RS01940	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E6C67_RS02060	COG1045	serine acetyltransferase
E6C67_RS02075	COG0287	Prephenate dehydrogenase
E6C67_RS02080	COG0583	DNA-binding transcription factor activity
E6C67_RS02095	COG1971	Probably functions as a manganese efflux pump
E6C67_RS02100	COG0402	S-adenosylhomocysteine deaminase activity
E6C67_RS02110	COG3385	transposase activity
E6C67_RS02115	COG1309	transcriptional regulator
E6C67_RS02120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_RS02125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C67_RS02150	COG0784	Response regulator, receiver
E6C67_RS02160	COG3214	Protein conserved in bacteria
E6C67_RS02165	COG1522	sequence-specific DNA binding
E6C67_RS02170	COG0586	Pfam SNARE associated Golgi protein
E6C67_RS02185	COG0427	acetyl-CoA hydrolase
E6C67_RS02195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E6C67_RS02200	COG2202	Pas domain
E6C67_RS02200	COG2205	protein histidine kinase activity
E6C67_RS02215	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_RS02220	COG2864	formate dehydrogenase
E6C67_RS02230	COG0437	4 iron, 4 sulfur cluster binding
E6C67_RS02235	COG3383	formate dehydrogenase (NAD+) activity
E6C67_RS02235	COG0243	molybdopterin cofactor binding
E6C67_RS02260	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E6C67_RS02280	COG4948	Mandelate Racemase Muconate Lactonizing
E6C67_RS02285	COG0583	DNA-binding transcription factor activity
E6C67_RS02310	COG0745	RESPONSE REGULATOR receiver
E6C67_RS02315	COG1278	Cold shock
E6C67_RS02340	COG2198	Histidine kinase
E6C67_RS02340	COG0643	Histidine kinase
E6C67_RS02340	COG0784	Response regulator, receiver
E6C67_RS02345	COG0835	chemotaxis
E6C67_RS02350	COG0784	Response regulator, receiver
E6C67_RS02350	COG2198	Histidine kinase
E6C67_RS02350	COG0643	Histidine kinase
E6C67_RS02365	COG2205	protein histidine kinase activity
E6C67_RS02380	COG3920	Histidine kinase
E6C67_RS02385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E6C67_RS02400	COG0531	amino acid
E6C67_RS02410	COG4303	Ethanolamine ammonia lyase large subunit
E6C67_RS02435	COG1280	lysine exporter protein (LysE YggA)
E6C67_RS02455	COG2723	6-phospho-beta-galactosidase activity
E6C67_RS02480	COG1295	ribonuclease BN
E6C67_RS02490	COG0861	Integral membrane protein TerC family
E6C67_RS02525	COG0793	Belongs to the peptidase S41A family
E6C67_RS02530	COG0736	holo-[acyl-carrier-protein] synthase activity
E6C67_RS02535	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E6C67_RS02540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E6C67_RS02545	COG0671	phosphoesterase, PA-phosphatase related
E6C67_RS02565	COG0848	biopolymer transport protein
E6C67_RS02580	COG4221	oxidoreductase activity
E6C67_RS02595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E6C67_RS02605	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
E6C67_RS02610	COG1595	DNA-templated transcription, initiation
E6C67_RS02615	COG3806	Anti-sigma factor
E6C67_RS02630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_RS02635	COG4597	amino acid ABC transporter
E6C67_RS02640	COG0765	amino acid transport
E6C67_RS02645	COG1126	abc transporter atp-binding protein
E6C67_RS02660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_RS02695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C67_RS02700	COG3920	Histidine kinase
E6C67_RS02710	COG2203	Gaf domain
E6C67_RS02710	COG2199	diguanylate cyclase activity
E6C67_RS02715	COG4566	intracellular signal transduction
E6C67_RS02715	COG0745	RESPONSE REGULATOR receiver
E6C67_RS02725	COG1454	alcohol dehydrogenase
E6C67_RS02735	COG0183	Belongs to the thiolase family
E6C67_RS02740	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS02750	COG1309	transcriptional regulator
E6C67_RS02755	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS02760	COG1024	Enoyl-CoA hydratase
E6C67_RS02780	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS02825	COG1674	ftsk spoiiie
E6C67_RS02885	COG1475	DNA binding
E6C67_RS02890	COG1192	Involved in chromosome partitioning
E6C67_RS02960	COG4962	Type ii secretion system protein e
E6C67_RS02975	COG3451	type IV secretory pathway VirB4
E6C67_RS02990	COG3846	protein secretion by the type IV secretion system
E6C67_RS02995	COG3701	Conjugal transfer protein
E6C67_RS03010	COG2948	multi-organism process
E6C67_RS03015	COG2135	peptidase activity
E6C67_RS03020	COG3177	Filamentation induced by cAMP protein fic
E6C67_RS03025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E6C67_RS03095	COG0586	Pfam SNARE associated Golgi protein
E6C67_RS03100	COG0671	phosphoesterase, PA-phosphatase related
E6C67_RS03105	COG0586	Pfam SNARE associated Golgi protein
E6C67_RS03110	COG5002	protein histidine kinase activity
E6C67_RS03120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_RS03130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_RS03140	COG2205	protein histidine kinase activity
E6C67_RS03150	COG2204	response regulator
E6C67_RS03245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E6C67_RS03250	COG1086	Polysaccharide biosynthesis protein
E6C67_RS03265	COG1216	Glycosyl transferase, family 2
E6C67_RS03265	COG0463	Glycosyl transferase, family 2
E6C67_RS03285	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E6C67_RS03285	COG0662	Cupin 2, conserved barrel domain protein
E6C67_RS03310	COG2274	protein secretion by the type I secretion system
E6C67_RS03315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_RS03330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C67_RS03335	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E6C67_RS03345	COG1091	dTDP-4-dehydrorhamnose reductase activity
E6C67_RS03350	COG1088	dTDP-glucose 4,6-dehydratase activity
E6C67_RS03355	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
E6C67_RS03360	COG0438	transferase activity, transferring glycosyl groups
E6C67_RS03360	COG1216	Glycosyl transferase, family 2
E6C67_RS03365	COG1216	Glycosyl transferase, family 2
E6C67_RS03365	COG0438	transferase activity, transferring glycosyl groups
E6C67_RS03405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E6C67_RS03410	COG0438	transferase activity, transferring glycosyl groups
E6C67_RS03410	COG0297	glycogen (starch) synthase activity
E6C67_RS03415	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E6C67_RS03420	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E6C67_RS03430	COG0500	methyltransferase
E6C67_RS03435	COG1132	(ABC) transporter
E6C67_RS03460	COG0463	Glycosyl transferase, family 2
E6C67_RS03475	COG0463	Glycosyl transferase, family 2
E6C67_RS03505	COG0859	PFAM glycosyl transferase family 9
E6C67_RS03505	COG0457	Tetratricopeptide repeat
E6C67_RS03520	COG2274	protein secretion by the type I secretion system
E6C67_RS03545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E6C67_RS03550	COG0519	Catalyzes the synthesis of GMP from XMP
E6C67_RS03555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E6C67_RS03565	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E6C67_RS03580	COG2089	acid synthase
E6C67_RS03600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E6C67_RS03620	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E6C67_RS03625	COG0107	imidazoleglycerol-phosphate synthase activity
E6C67_RS03640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C67_RS03665	COG0438	transferase activity, transferring glycosyl groups
E6C67_RS03760	COG1192	Involved in chromosome partitioning
E6C67_RS03765	COG1475	DNA binding
E6C67_RS03790	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
E6C67_RS03800	COG3504	Conjugal transfer protein
E6C67_RS03805	COG3736	Type IV secretory pathway, component VirB8
E6C67_RS03825	COG3451	type IV secretory pathway VirB4
E6C67_RS03830	COG3702	type iv secretory pathway
E6C67_RS03860	COG2885	chlorophyll binding
E6C67_RS03925	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_RS03985	COG4106	trans-aconitate 2-methyltransferase activity
E6C67_RS03990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E6C67_RS04020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E6C67_RS04040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E6C67_RS04065	COG0789	Transcriptional regulator
E6C67_RS04070	COG4191	Histidine kinase
E6C67_RS04070	COG0784	Response regulator, receiver
E6C67_RS04075	COG1686	Belongs to the peptidase S11 family
E6C67_RS04085	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E6C67_RS04095	COG2321	neutral zinc metallopeptidase
E6C67_RS04140	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E6C67_RS04145	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E6C67_RS04160	COG0175	sulfate reduction
E6C67_RS04235	COG1643	Atp-dependent helicase
E6C67_RS04250	COG4520	surface antigen
E6C67_RS04265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E6C67_RS04290	COG3958	Transketolase
E6C67_RS04295	COG3959	Transketolase, thiamine diphosphate binding domain
E6C67_RS04305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C67_RS04315	COG1216	Glycosyl transferase, family 2
E6C67_RS04315	COG1442	glycosyl transferase family 8
E6C67_RS04320	COG2046	Belongs to the sulfate adenylyltransferase family
E6C67_RS04320	COG0529	Catalyzes the synthesis of activated sulfate
E6C67_RS04335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E6C67_RS04340	COG1213	nucleotidyl transferase
E6C67_RS04355	COG3848	Pyruvate phosphate dikinase
E6C67_RS04355	COG0574	Belongs to the PEP-utilizing enzyme family
E6C67_RS04370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E6C67_RS04415	COG4638	Rieske (2fe-2S)
E6C67_RS04500	COG4106	trans-aconitate 2-methyltransferase activity
E6C67_RS04510	COG0675	Transposase, IS605 OrfB family
E6C67_RS04525	COG4626	Terminase
E6C67_RS04525	COG1802	Transcriptional regulator
E6C67_RS04545	COG1129	ABC transporter
E6C67_RS04550	COG4214	carbohydrate transport
E6C67_RS04555	COG4213	ABC transporter substrate-binding protein
E6C67_RS04560	COG2115	Belongs to the xylose isomerase family
E6C67_RS04565	COG1070	Carbohydrate kinase
E6C67_RS04570	COG1609	Transcriptional regulator
E6C67_RS04595	COG2353	YceI-like domain
E6C67_RS04600	COG0435	Glutathione S-transferase
E6C67_RS04630	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS04645	COG0826	peptidase U32
E6C67_RS04655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E6C67_RS04685	COG4263	nitrous-oxide reductase activity
E6C67_RS04695	COG4459	periplasmic nitrate reductase
E6C67_RS04705	COG3062	negative regulation of establishment of protein localization
E6C67_RS04720	COG3005	denitrification pathway
E6C67_RS04725	COG1475	DNA binding
E6C67_RS04730	COG1192	Involved in chromosome partitioning
E6C67_RS04735	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS04745	COG0840	transmembrane signaling receptor activity
E6C67_RS04755	COG3437	response regulator, receiver
E6C67_RS04760	COG1320	monovalent cation:proton antiporter activity
E6C67_RS04765	COG2212	antiporter activity
E6C67_RS04770	COG1863	multisubunit Na H antiporter MnhE subunit
E6C67_RS04775	COG0651	ATP synthesis coupled electron transport
E6C67_RS04780	COG1006	Multisubunit Na H antiporter MnhC subunit
E6C67_RS04785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E6C67_RS04785	COG2111	Na H antiporter
E6C67_RS04800	COG4191	Histidine kinase
E6C67_RS04805	COG4566	intracellular signal transduction
E6C67_RS04840	COG2814	Major facilitator Superfamily
E6C67_RS04870	COG2186	Transcriptional regulator
E6C67_RS04890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C67_RS04895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_RS04900	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS04905	COG1960	acyl-CoA dehydrogenase activity
E6C67_RS04915	COG0183	Belongs to the thiolase family
E6C67_RS04940	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS04950	COG1032	radical SAM domain protein
E6C67_RS05000	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E6C67_RS05020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_RS05025	COG3002	Belongs to the UPF0753 family
E6C67_RS05030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E6C67_RS05040	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS05045	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E6C67_RS05050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_RS05055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E6C67_RS05070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_RS05105	COG0583	DNA-binding transcription factor activity
E6C67_RS05110	COG0747	negative chemotaxis
E6C67_RS05120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C67_RS05125	COG0444	Belongs to the ABC transporter superfamily
E6C67_RS05130	COG4608	Belongs to the ABC transporter superfamily
E6C67_RS05150	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E6C67_RS05155	COG1522	sequence-specific DNA binding
E6C67_RS05165	COG0251	oxidation-reduction process
E6C67_RS05210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E6C67_RS05220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C67_RS05255	COG0300	oxidoreductase activity
E6C67_RS05310	COG1960	acyl-CoA dehydrogenase activity
E6C67_RS05335	COG0444	Belongs to the ABC transporter superfamily
E6C67_RS05350	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E6C67_RS05360	COG0601	transmembrane transport
E6C67_RS05405	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS05420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_RS05425	COG1473	amidohydrolase
E6C67_RS05430	COG0859	PFAM glycosyl transferase family 9
E6C67_RS05430	COG0457	Tetratricopeptide repeat
E6C67_RS05455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E6C67_RS05500	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS05505	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS05525	COG3273	potassium ion transport
E6C67_RS05525	COG0471	metal ion transport
E6C67_RS05530	COG0517	IMP dehydrogenase activity
E6C67_RS05540	COG0784	Response regulator, receiver
E6C67_RS05550	COG1758	RNA polymerase activity
E6C67_RS05555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E6C67_RS05580	COG1914	H( )-stimulated, divalent metal cation uptake system
E6C67_RS05585	COG1321	iron dependent repressor
E6C67_RS05595	COG1918	ferrous iron import across plasma membrane
E6C67_RS05595	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E6C67_RS05605	COG2814	Major facilitator Superfamily
E6C67_RS05610	COG0596	Alpha beta hydrolase
E6C67_RS05610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E6C67_RS05625	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E6C67_RS05640	COG0583	DNA-binding transcription factor activity
E6C67_RS05655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E6C67_RS05700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E6C67_RS05765	COG0395	ABC-type sugar transport system, permease component
E6C67_RS05770	COG1175	transmembrane transport
E6C67_RS05780	COG1940	carbohydrate kinase activity
E6C67_RS05785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C67_RS05790	COG0348	domain, Protein
E6C67_RS05830	COG0010	Belongs to the arginase family
E6C67_RS05850	COG0025	NhaP-type Na H and K H
E6C67_RS05865	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E6C67_RS05875	COG1335	isochorismatase
E6C67_RS05890	COG0673	inositol 2-dehydrogenase activity
E6C67_RS05900	COG1879	ABC-type sugar transport system periplasmic component
E6C67_RS05905	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS05910	COG1129	ABC transporter
E6C67_RS05920	COG0840	transmembrane signaling receptor activity
E6C67_RS05940	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C67_RS05940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C67_RS05945	COG1263	PTS System
E6C67_RS05945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E6C67_RS05950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E6C67_RS05955	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E6C67_RS05960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E6C67_RS05965	COG2188	Transcriptional regulator
E6C67_RS05970	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E6C67_RS05975	COG2190	(PTS) system
E6C67_RS05975	COG1263	PTS System
E6C67_RS05975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E6C67_RS05985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E6C67_RS05990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_RS05995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_RS06000	COG1116	anion transmembrane transporter activity
E6C67_RS06025	COG4191	Histidine kinase
E6C67_RS06030	COG1301	dicarboxylic acid transport
E6C67_RS06035	COG1027	Aspartate ammonia-lyase
E6C67_RS06040	COG2258	MOSC domain
E6C67_RS06045	COG3622	Belongs to the hyi family
E6C67_RS06055	COG0604	alcohol dehydrogenase
E6C67_RS06060	COG0583	DNA-binding transcription factor activity
E6C67_RS06065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E6C67_RS06070	COG4191	Histidine kinase
E6C67_RS06075	COG4566	intracellular signal transduction
E6C67_RS06085	COG0784	Response regulator, receiver
E6C67_RS06085	COG2205	protein histidine kinase activity
E6C67_RS06090	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E6C67_RS06105	COG0583	DNA-binding transcription factor activity
E6C67_RS06110	COG0667	Aldo Keto reductase
E6C67_RS06115	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS06120	COG4191	Histidine kinase
E6C67_RS06140	COG1982	Orn Lys Arg decarboxylase major
E6C67_RS06155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E6C67_RS06165	COG1802	Transcriptional regulator
E6C67_RS06175	COG2226	methyltransferase
E6C67_RS06180	COG1802	Transcriptional regulator
E6C67_RS06185	COG0179	Fumarylacetoacetate (FAA) hydrolase
E6C67_RS06195	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS06205	COG1937	Protein conserved in bacteria
E6C67_RS06215	COG3012	SEC-C Motif Domain Protein
E6C67_RS06225	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E6C67_RS06230	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_RS06235	COG1522	sequence-specific DNA binding
E6C67_RS06240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C67_RS06245	COG1126	abc transporter atp-binding protein
E6C67_RS06250	COG0765	amino acid transport
E6C67_RS06255	COG0765	amino acid transport
E6C67_RS06265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E6C67_RS06270	COG2423	ornithine cyclodeaminase activity
E6C67_RS06275	COG0006	proline dipeptidase activity
E6C67_RS06280	COG3608	succinylglutamate desuccinylase aspartoacylase
E6C67_RS06290	COG0583	DNA-binding transcription factor activity
E6C67_RS06295	COG2828	Protein conserved in bacteria
E6C67_RS06300	COG1301	dicarboxylic acid transport
E6C67_RS06305	COG0745	RESPONSE REGULATOR receiver
E6C67_RS06320	COG0668	transmembrane transport
E6C67_RS06325	COG1760	l-serine dehydratase
E6C67_RS06330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E6C67_RS06340	COG0446	pyridine nucleotide-disulphide oxidoreductase
E6C67_RS06340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E6C67_RS06385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C67_RS06405	COG0730	response to heat
E6C67_RS06410	COG4191	Histidine kinase
E6C67_RS06415	COG4566	intracellular signal transduction
E6C67_RS06420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E6C67_RS06450	COG0737	Belongs to the 5'-nucleotidase family
E6C67_RS06480	COG2188	Transcriptional regulator
E6C67_RS06485	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS06490	COG0583	DNA-binding transcription factor activity
E6C67_RS06515	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS06520	COG1309	transcriptional regulator
E6C67_RS06525	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS06535	COG1414	Transcriptional regulator
E6C67_RS06540	COG1234	tRNA 3'-trailer cleavage
E6C67_RS06550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E6C67_RS06555	COG0066	3-isopropylmalate dehydratase activity
E6C67_RS06590	COG0277	FAD linked oxidase domain protein
E6C67_RS06595	COG2226	methyltransferase
E6C67_RS06600	COG2814	Major facilitator Superfamily
E6C67_RS06610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E6C67_RS06620	COG4221	oxidoreductase activity
E6C67_RS06640	COG0697	spore germination
E6C67_RS06645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C67_RS06660	COG1295	ribonuclease BN
E6C67_RS06670	COG0583	DNA-binding transcription factor activity
E6C67_RS06675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E6C67_RS06680	COG0235	Class ii aldolase
E6C67_RS06695	COG0601	transmembrane transport
E6C67_RS06700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C67_RS06710	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E6C67_RS06760	COG3052	prosthetic group binding
E6C67_RS06780	COG1802	Transcriptional regulator
E6C67_RS06785	COG5001	Diguanylate cyclase
E6C67_RS06790	COG2116	formate transmembrane transporter activity
E6C67_RS06795	COG0148	phosphopyruvate hydratase activity
E6C67_RS06810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E6C67_RS06820	COG0126	phosphoglycerate kinase activity
E6C67_RS06845	COG0583	DNA-binding transcription factor activity
E6C67_RS06850	COG0300	oxidoreductase activity
E6C67_RS06865	COG4566	intracellular signal transduction
E6C67_RS06875	COG0515	serine threonine protein kinase
E6C67_RS06875	COG2815	serine threonine protein kinase
E6C67_RS06885	COG4977	sequence-specific DNA binding
E6C67_RS06900	COG2855	membrane
E6C67_RS06925	COG1522	sequence-specific DNA binding
E6C67_RS06935	COG2706	6-phosphogluconolactonase activity
E6C67_RS06940	COG2721	sulfolactate sulfo-lyase activity
E6C67_RS06955	COG1312	Catalyzes the dehydration of D-mannonate
E6C67_RS06960	COG2271	Major facilitator Superfamily
E6C67_RS06965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E6C67_RS06970	COG2186	Transcriptional regulator
E6C67_RS06995	COG3976	FMN-binding domain protein
E6C67_RS06995	COG1053	succinate dehydrogenase
E6C67_RS06995	COG0431	NADPH-dependent FMN reductase
E6C67_RS07020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E6C67_RS07040	COG0784	Response regulator, receiver
E6C67_RS07040	COG2205	protein histidine kinase activity
E6C67_RS07040	COG2198	Histidine kinase
E6C67_RS07050	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E6C67_RS07065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C67_RS07090	COG0437	4 iron, 4 sulfur cluster binding
E6C67_RS07125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E6C67_RS07130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E6C67_RS07135	COG1845	cytochrome c oxidase, subunit III
E6C67_RS07175	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
E6C67_RS07180	COG0702	epimerase
E6C67_RS07195	COG1229	Formylmethanofuran dehydrogenase subunit A
E6C67_RS07200	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
E6C67_RS07225	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
E6C67_RS07240	COG0189	ligase activity
E6C67_RS07240	COG4067	protein conserved in archaea
E6C67_RS07250	COG1131	(ABC) transporter
E6C67_RS07305	COG3383	formate dehydrogenase (NAD+) activity
E6C67_RS07315	COG0546	phosphoglycolate phosphatase activity
E6C67_RS07320	COG0191	fructose-bisphosphate aldolase activity
E6C67_RS07325	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E6C67_RS07330	COG3954	Phosphoribulokinase
E6C67_RS07335	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E6C67_RS07345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E6C67_RS07355	COG1850	ribulose-bisphosphate carboxylase activity
E6C67_RS07360	COG0583	DNA-binding transcription factor activity
E6C67_RS07365	COG1349	DNA-binding transcription factor activity
E6C67_RS07370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E6C67_RS07375	COG1879	ABC-type sugar transport system periplasmic component
E6C67_RS07380	COG1129	ABC transporter
E6C67_RS07385	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS07390	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS07400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E6C67_RS07405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E6C67_RS07420	COG2233	PERMEase
E6C67_RS07465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_RS07480	COG1609	Transcriptional regulator
E6C67_RS07485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_RS07490	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_RS07500	COG1850	ribulose-bisphosphate carboxylase activity
E6C67_RS07515	COG0251	oxidation-reduction process
E6C67_RS07525	COG0251	oxidation-reduction process
E6C67_RS07570	COG1177	transmembrane transport
E6C67_RS07580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_RS07590	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E6C67_RS07600	COG0673	inositol 2-dehydrogenase activity
E6C67_RS07615	COG1309	transcriptional regulator
E6C67_RS07620	COG3387	PFAM Glycoside hydrolase 15-related
E6C67_RS07630	COG0277	FAD linked oxidase domain protein
E6C67_RS07630	COG0247	lactate metabolic process
E6C67_RS07635	COG4948	Mandelate Racemase Muconate Lactonizing
E6C67_RS07640	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_RS07640	COG1454	alcohol dehydrogenase
E6C67_RS07645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C67_RS07650	COG4566	intracellular signal transduction
E6C67_RS07655	COG4566	intracellular signal transduction
E6C67_RS07660	COG4191	Histidine kinase
E6C67_RS07675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E6C67_RS07720	COG1706	bacterial-type flagellum-dependent cell motility
E6C67_RS07730	COG1256	bacterial-type flagellum assembly
E6C67_RS07735	COG1749	Flagellar hook protein flgE
E6C67_RS07750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E6C67_RS07760	COG4786	Flagellar basal body rod
E6C67_RS07765	COG4786	Flagellar basal body rod
E6C67_RS07770	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E6C67_RS07775	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E6C67_RS07820	COG1766	The M ring may be actively involved in energy transduction
E6C67_RS07830	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C67_RS07840	COG1338	Plays a role in the flagellum-specific transport system
E6C67_RS07850	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C67_RS07865	COG0745	RESPONSE REGULATOR receiver
E6C67_RS07870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E6C67_RS07875	COG5442	Flagellar protein FlaF
E6C67_RS07880	COG5443	negative regulation of bacterial-type flagellum assembly
E6C67_RS07895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E6C67_RS07925	COG1558	bacterial-type flagellum-dependent cell motility
E6C67_RS07930	COG1677	Flagellar hook-basal body complex protein FliE
E6C67_RS07945	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E6C67_RS07955	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E6C67_RS07965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E6C67_RS07970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E6C67_RS07975	COG0351	phosphomethylpyrimidine kinase
E6C67_RS07980	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E6C67_RS07995	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E6C67_RS08000	COG1845	cytochrome c oxidase, subunit III
E6C67_RS08005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E6C67_RS08010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E6C67_RS08015	COG0477	Major facilitator Superfamily
E6C67_RS08065	COG1988	membrane-bound metal-dependent
E6C67_RS08085	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E6C67_RS08175	COG3561	AntA/AntB antirepressor
E6C67_RS08255	COG3756	Protein conserved in bacteria
E6C67_RS08550	COG0675	Transposase, IS605 OrfB family
E6C67_RS08575	COG2814	Major facilitator Superfamily
E6C67_RS08590	COG4178	(ABC) transporter
E6C67_RS08605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E6C67_RS08615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E6C67_RS08665	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS08670	COG0583	DNA-binding transcription factor activity
E6C67_RS08680	COG4993	Dehydrogenase
E6C67_RS08685	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C67_RS08695	COG2086	electron transfer activity
E6C67_RS08710	COG2723	6-phospho-beta-galactosidase activity
E6C67_RS08735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E6C67_RS08740	COG1127	ABC transporter
E6C67_RS08745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E6C67_RS08750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E6C67_RS08755	COG0305	Participates in initiation and elongation during chromosome replication
E6C67_RS08785	COG0598	Magnesium transport protein CorA
E6C67_RS08825	COG2184	nucleotidyltransferase activity
E6C67_RS08855	COG1484	DNA-dependent DNA replication
E6C67_RS08860	COG4584	PFAM Integrase catalytic
E6C67_RS08890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E6C67_RS08910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E6C67_RS08915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E6C67_RS08925	COG3218	ABC-type transport auxiliary lipoprotein component
E6C67_RS08925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E6C67_RS08955	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E6C67_RS08970	COG2703	oxygen carrier activity
E6C67_RS08985	COG0521	Mo-molybdopterin cofactor biosynthetic process
E6C67_RS08990	COG0741	lytic transglycosylase activity
E6C67_RS08995	COG1573	uracil-dna glycosylase
E6C67_RS09015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_RS09030	COG1139	Iron-sulfur cluster binding protein
E6C67_RS09035	COG0247	lactate metabolic process
E6C67_RS09045	COG1620	l-lactate permease
E6C67_RS09050	COG2186	Transcriptional regulator
E6C67_RS09055	COG2204	response regulator
E6C67_RS09070	COG0372	Belongs to the citrate synthase family
E6C67_RS09085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_RS09085	COG2205	protein histidine kinase activity
E6C67_RS09100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_RS09115	COG1737	Transcriptional regulator
E6C67_RS09130	COG3604	Transcriptional regulator
E6C67_RS09140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_RS09145	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E6C67_RS09155	COG3290	protein histidine kinase activity
E6C67_RS09155	COG3829	transcription factor binding
E6C67_RS09165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_RS09175	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_RS09180	COG1063	alcohol dehydrogenase
E6C67_RS09185	COG0246	Mannitol dehydrogenase
E6C67_RS09190	COG1802	Transcriptional regulator
E6C67_RS09195	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C67_RS09205	COG3842	ATPase activity
E6C67_RS09215	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E6C67_RS09235	COG5002	protein histidine kinase activity
E6C67_RS09235	COG2205	protein histidine kinase activity
E6C67_RS09235	COG0784	Response regulator, receiver
E6C67_RS09240	COG3437	response regulator, receiver
E6C67_RS09245	COG3416	Protein conserved in bacteria
E6C67_RS09255	COG3920	Histidine kinase
E6C67_RS09265	COG0300	oxidoreductase activity
E6C67_RS09270	COG5265	(ABC) transporter
E6C67_RS09275	COG3385	transposase activity
E6C67_RS09280	COG1032	radical SAM domain protein
E6C67_RS09300	COG0583	DNA-binding transcription factor activity
E6C67_RS09310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E6C67_RS09320	COG0573	inorganic phosphate transmembrane transporter activity
E6C67_RS09325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E6C67_RS09335	COG0625	glutathione transferase activity
E6C67_RS09340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E6C67_RS09375	COG2814	Major facilitator Superfamily
E6C67_RS09380	COG1744	ABC transporter substrate-binding protein PnrA-like
E6C67_RS09390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E6C67_RS09410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C67_RS09425	COG2885	chlorophyll binding
E6C67_RS09425	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E6C67_RS09480	COG1940	carbohydrate kinase activity
E6C67_RS09500	COG0463	Glycosyl transferase, family 2
E6C67_RS09520	COG4191	Histidine kinase
E6C67_RS09520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_RS09545	COG1858	cytochrome C peroxidase
E6C67_RS09560	COG4191	Histidine kinase
E6C67_RS09590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E6C67_RS09615	COG3842	ATPase activity
E6C67_RS09620	COG3842	ATPase activity
E6C67_RS09635	COG1349	DNA-binding transcription factor activity
E6C67_RS09690	COG0697	spore germination
E6C67_RS09700	COG0569	domain protein
E6C67_RS09705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E6C67_RS09750	COG1116	anion transmembrane transporter activity
E6C67_RS09755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_RS09760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E6C67_RS09765	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C67_RS09790	COG1032	radical SAM domain protein
E6C67_RS09795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C67_RS09810	COG0406	alpha-ribazole phosphatase activity
E6C67_RS09830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E6C67_RS09845	COG1648	precorrin-2 dehydrogenase activity
E6C67_RS09845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E6C67_RS09855	COG0243	molybdopterin cofactor binding
E6C67_RS09865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E6C67_RS09870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E6C67_RS09880	COG1116	anion transmembrane transporter activity
E6C67_RS09885	COG0656	L-ascorbic acid biosynthetic process
E6C67_RS09920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E6C67_RS09925	COG2017	converts alpha-aldose to the beta-anomer
E6C67_RS09930	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS09935	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS09940	COG1129	ABC transporter
E6C67_RS09950	COG1879	ABC-type sugar transport system periplasmic component
E6C67_RS09985	COG1129	ABC transporter
E6C67_RS09990	COG4214	carbohydrate transport
E6C67_RS10000	COG0840	transmembrane signaling receptor activity
E6C67_RS10005	COG0129	dihydroxy-acid dehydratase activity
E6C67_RS10025	COG1966	Carbon starvation protein
E6C67_RS10030	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS10055	COG1794	racemase activity, acting on amino acids and derivatives
E6C67_RS10060	COG3279	Response regulator of the LytR AlgR family
E6C67_RS10065	COG3275	phosphorelay sensor kinase activity
E6C67_RS10075	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS10085	COG0644	oxidoreductase
E6C67_RS10090	COG0583	DNA-binding transcription factor activity
E6C67_RS10105	COG1192	Involved in chromosome partitioning
E6C67_RS10130	COG4221	oxidoreductase activity
E6C67_RS10130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E6C67_RS10130	COG3321	synthase
E6C67_RS10130	COG0604	alcohol dehydrogenase
E6C67_RS10145	COG1686	Belongs to the peptidase S11 family
E6C67_RS10155	COG1609	Transcriptional regulator
E6C67_RS10160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E6C67_RS10165	COG1126	abc transporter atp-binding protein
E6C67_RS10170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_RS10175	COG0765	amino acid transport
E6C67_RS10180	COG0765	amino acid transport
E6C67_RS10185	COG2814	Major facilitator Superfamily
E6C67_RS10195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_RS10200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C67_RS10235	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E6C67_RS10250	COG0277	FAD linked oxidase domain protein
E6C67_RS10250	COG0247	lactate metabolic process
E6C67_RS10255	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E6C67_RS10260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_RS10270	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E6C67_RS10270	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_RS10275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_RS10285	COG0583	DNA-binding transcription factor activity
E6C67_RS10295	COG0747	negative chemotaxis
E6C67_RS10300	COG0601	transmembrane transport
E6C67_RS10305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C67_RS10350	COG0596	Alpha beta hydrolase
E6C67_RS10365	COG1960	acyl-CoA dehydrogenase activity
E6C67_RS10370	COG0583	DNA-binding transcription factor activity
E6C67_RS10375	COG0183	Belongs to the thiolase family
E6C67_RS10385	COG2086	electron transfer activity
E6C67_RS10400	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS10415	COG0372	Belongs to the citrate synthase family
E6C67_RS10425	COG1053	succinate dehydrogenase
E6C67_RS10425	COG3976	FMN-binding domain protein
E6C67_RS10430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_RS10440	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_RS10445	COG1414	Transcriptional regulator
E6C67_RS10460	COG0583	DNA-binding transcription factor activity
E6C67_RS10470	COG0246	Mannitol dehydrogenase
E6C67_RS10475	COG1312	Catalyzes the dehydration of D-mannonate
E6C67_RS10480	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C67_RS10490	COG2814	Major facilitator Superfamily
E6C67_RS10500	COG4221	oxidoreductase activity
E6C67_RS10505	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS10515	COG0583	DNA-binding transcription factor activity
E6C67_RS10520	COG0702	epimerase
E6C67_RS10550	COG0513	Belongs to the DEAD box helicase family
E6C67_RS10570	COG0784	Response regulator, receiver
E6C67_RS10570	COG4191	Histidine kinase
E6C67_RS10645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E6C67_RS10670	COG2207	Transcriptional regulator
E6C67_RS10695	COG0523	cobalamin synthesis protein
E6C67_RS10745	COG0655	NAD(P)H dehydrogenase (quinone) activity
E6C67_RS10750	COG0583	DNA-binding transcription factor activity
E6C67_RS10765	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E6C67_RS10775	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_RS10795	COG0587	DNA-directed DNA polymerase activity
E6C67_RS10805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E6C67_RS10810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E6C67_RS10825	COG1522	sequence-specific DNA binding
E6C67_RS10835	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E6C67_RS10860	COG1396	sequence-specific DNA binding
E6C67_RS10890	COG1484	DNA-dependent DNA replication
E6C67_RS10895	COG4584	PFAM Integrase catalytic
E6C67_RS10925	COG1396	sequence-specific DNA binding
E6C67_RS10930	COG3550	peptidyl-serine autophosphorylation
E6C67_RS10970	COG3547	Transposase (IS116 IS110 IS902 family)
E6C67_RS10975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_RS11005	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E6C67_RS11010	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E6C67_RS11015	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E6C67_RS11020	COG2205	protein histidine kinase activity
E6C67_RS11025	COG0745	RESPONSE REGULATOR receiver
E6C67_RS11075	COG3093	addiction module antidote protein HigA
E6C67_RS11135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_RS11145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E6C67_RS11155	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E6C67_RS11165	COG4584	PFAM Integrase catalytic
E6C67_RS11170	COG1484	DNA-dependent DNA replication
E6C67_RS11200	COG2390	Transcriptional regulator
E6C67_RS11200	COG4584	PFAM Integrase catalytic
E6C67_RS11205	COG1484	DNA-dependent DNA replication
E6C67_RS11245	COG2948	multi-organism process
E6C67_RS11265	COG2948	multi-organism process
E6C67_RS11295	COG1802	Transcriptional regulator
E6C67_RS11295	COG4626	Terminase
E6C67_RS11300	COG3328	transposase activity
E6C67_RS11350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E6C67_RS11405	COG2197	response regulator
E6C67_RS11425	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E6C67_RS11445	COG4191	Histidine kinase
E6C67_RS11445	COG0784	Response regulator, receiver
E6C67_RS11465	COG0583	DNA-binding transcription factor activity
E6C67_RS11470	COG1733	regulation of RNA biosynthetic process
E6C67_RS11475	COG0604	alcohol dehydrogenase
E6C67_RS11485	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS11490	COG4948	Mandelate Racemase Muconate Lactonizing
E6C67_RS11500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_RS11505	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_RS11515	COG0395	ABC-type sugar transport system, permease component
E6C67_RS11520	COG1175	transmembrane transport
E6C67_RS11525	COG1653	transport
E6C67_RS11530	COG3842	ATPase activity
E6C67_RS11545	COG4670	ketone body catabolic process
E6C67_RS11550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E6C67_RS11580	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS11595	COG1802	Transcriptional regulator
E6C67_RS11600	COG0179	Fumarylacetoacetate (FAA) hydrolase
E6C67_RS11630	COG4584	PFAM Integrase catalytic
E6C67_RS11635	COG1484	DNA-dependent DNA replication
E6C67_RS11645	COG3436	PFAM IS66 Orf2 family protein
E6C67_RS11665	COG0726	polysaccharide deacetylase
E6C67_RS11670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_RS11690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_RS11700	COG1414	Transcriptional regulator
E6C67_RS11710	COG4584	PFAM Integrase catalytic
E6C67_RS11710	COG2390	Transcriptional regulator
E6C67_RS11715	COG1484	DNA-dependent DNA replication
E6C67_RS11755	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C67_RS11760	COG1177	transmembrane transport
E6C67_RS11765	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS11770	COG1802	Transcriptional regulator
E6C67_RS11780	COG3958	Transketolase
E6C67_RS11785	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E6C67_RS11790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E6C67_RS11800	COG3842	ATPase activity
E6C67_RS11820	COG1454	alcohol dehydrogenase
E6C67_RS11830	COG0183	Belongs to the thiolase family
E6C67_RS11835	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS11845	COG1309	transcriptional regulator
E6C67_RS11850	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS11855	COG1024	Enoyl-CoA hydratase
E6C67_RS11875	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS11895	COG0601	transmembrane transport
E6C67_RS11905	COG0747	negative chemotaxis
E6C67_RS11910	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E6C67_RS11915	COG0583	DNA-binding transcription factor activity
E6C67_RS11935	COG2814	Major facilitator Superfamily
E6C67_RS11950	COG4670	ketone body catabolic process
E6C67_RS11960	COG1053	succinate dehydrogenase
E6C67_RS11960	COG3976	FMN-binding domain protein
E6C67_RS11970	COG0583	DNA-binding transcription factor activity
E6C67_RS11985	COG0747	negative chemotaxis
E6C67_RS11990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C67_RS12005	COG1473	amidohydrolase
E6C67_RS12010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E6C67_RS12030	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS12035	COG0583	DNA-binding transcription factor activity
E6C67_RS12045	COG0583	DNA-binding transcription factor activity
E6C67_RS12050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_RS12055	COG1522	sequence-specific DNA binding
E6C67_RS12060	COG4172	Belongs to the ABC transporter superfamily
E6C67_RS12065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C67_RS12070	COG0601	transmembrane transport
E6C67_RS12075	COG0747	negative chemotaxis
E6C67_RS12090	COG0454	-acetyltransferase
E6C67_RS12100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_RS12115	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_RS12125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E6C67_RS12145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_RS12170	COG0583	DNA-binding transcription factor activity
E6C67_RS12175	COG1902	pentaerythritol trinitrate reductase activity
E6C67_RS12175	COG0446	pyridine nucleotide-disulphide oxidoreductase
E6C67_RS12190	COG0655	NAD(P)H dehydrogenase (quinone) activity
E6C67_RS12245	COG4584	PFAM Integrase catalytic
E6C67_RS12245	COG2390	Transcriptional regulator
E6C67_RS12250	COG1484	DNA-dependent DNA replication
E6C67_RS12260	COG2186	Transcriptional regulator
E6C67_RS12265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_RS12270	COG0765	amino acid transport
E6C67_RS12285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E6C67_RS12295	COG2807	transmembrane transport
E6C67_RS12320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_RS12335	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS12350	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS12355	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS12375	COG1024	Enoyl-CoA hydratase
E6C67_RS12410	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS12425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E6C67_RS12435	COG3829	transcription factor binding
E6C67_RS12445	COG1960	acyl-CoA dehydrogenase activity
E6C67_RS12450	COG5285	phytanoyl-CoA dioxygenase
E6C67_RS12495	COG2084	Dehydrogenase
E6C67_RS12560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E6C67_RS12590	COG4615	Cyclic peptide transporter
E6C67_RS12665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E6C67_RS12670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E6C67_RS12675	COG0583	DNA-binding transcription factor activity
E6C67_RS12685	COG3842	ATPase activity
E6C67_RS12690	COG1840	ABC-type Fe3 transport system, periplasmic component
E6C67_RS12705	COG1595	DNA-templated transcription, initiation
E6C67_RS12740	COG0411	ABC transporter
E6C67_RS12745	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS12755	COG0683	leucine binding
E6C67_RS12765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E6C67_RS12825	COG0649	NAD binding
E6C67_RS12830	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E6C67_RS12840	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E6C67_RS12845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E6C67_RS12850	COG0651	ATP synthesis coupled electron transport
E6C67_RS12855	COG2111	Na H antiporter
E6C67_RS12855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E6C67_RS12865	COG2414	aldehyde ferredoxin oxidoreductase
E6C67_RS12885	COG1136	(ABC) transporter
E6C67_RS12885	COG0577	efflux transmembrane transporter activity
E6C67_RS12890	COG0577	efflux transmembrane transporter activity
E6C67_RS12890	COG1136	(ABC) transporter
E6C67_RS12895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_RS12915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E6C67_RS12930	COG4176	ABC-type proline glycine betaine transport system permease component
E6C67_RS12935	COG4175	Glycine betaine
E6C67_RS12950	COG0247	lactate metabolic process
E6C67_RS12950	COG2181	nitrate reductase activity
E6C67_RS12955	COG0446	pyridine nucleotide-disulphide oxidoreductase
E6C67_RS12955	COG1902	pentaerythritol trinitrate reductase activity
E6C67_RS12990	COG2223	nitrite transmembrane transporter activity
E6C67_RS13010	COG0577	efflux transmembrane transporter activity
E6C67_RS13010	COG1136	(ABC) transporter
E6C67_RS13015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E6C67_RS13035	COG1522	sequence-specific DNA binding
E6C67_RS13060	COG0683	leucine binding
E6C67_RS13075	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E6C67_RS13095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E6C67_RS13115	COG2188	Transcriptional regulator
E6C67_RS13125	COG0405	Gamma-glutamyltransferase
E6C67_RS13130	COG2186	Transcriptional regulator
E6C67_RS13135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E6C67_RS13140	COG2204	response regulator
E6C67_RS13145	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C67_RS13150	COG3246	L-lysine catabolic process to acetate
E6C67_RS13155	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS13185	COG1960	acyl-CoA dehydrogenase activity
E6C67_RS13200	COG2010	Cytochrome c
E6C67_RS13200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E6C67_RS13205	COG2080	2 iron, 2 sulfur cluster binding
E6C67_RS13210	COG1846	Transcriptional regulator
E6C67_RS13215	COG2309	aminopeptidase activity
E6C67_RS13220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E6C67_RS13225	COG0596	Alpha beta hydrolase
E6C67_RS13230	COG3473	Maleate cis-trans isomerase
E6C67_RS13235	COG1335	isochorismatase
E6C67_RS13240	COG2271	Major facilitator Superfamily
E6C67_RS13275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E6C67_RS13285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E6C67_RS13300	COG0405	Gamma-glutamyltransferase
E6C67_RS13305	COG0583	DNA-binding transcription factor activity
E6C67_RS13310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E6C67_RS13315	COG4948	Mandelate Racemase Muconate Lactonizing
E6C67_RS13325	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_RS13330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_RS13355	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
E6C67_RS13360	COG0277	FAD linked oxidase domain protein
E6C67_RS13370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E6C67_RS13385	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E6C67_RS13390	COG0567	Dehydrogenase, E1 component
E6C67_RS13410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_RS13415	COG3328	transposase activity
E6C67_RS13420	COG3328	transposase activity
E6C67_RS13425	COG4584	PFAM Integrase catalytic
E6C67_RS13440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E6C67_RS13460	COG2801	Transposase and inactivated derivatives
E6C67_RS13470	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_RS13475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E6C67_RS13480	COG0596	Alpha beta hydrolase
E6C67_RS13500	COG4176	ABC-type proline glycine betaine transport system permease component
E6C67_RS13505	COG2113	Glycine betaine
E6C67_RS13535	COG3842	ATPase activity
E6C67_RS13550	COG2204	response regulator
E6C67_RS13555	COG4191	Histidine kinase
E6C67_RS13570	COG1846	Transcriptional regulator
E6C67_RS13575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E6C67_RS13575	COG0785	Cytochrome C biogenesis protein
E6C67_RS13590	COG2205	protein histidine kinase activity
E6C67_RS13600	COG0488	(ABC) transporter
E6C67_RS13605	COG0596	Alpha beta hydrolase
E6C67_RS13610	COG1959	2 iron, 2 sulfur cluster binding
E6C67_RS13625	COG0583	DNA-binding transcription factor activity
E6C67_RS13640	COG1959	2 iron, 2 sulfur cluster binding
E6C67_RS13650	COG1051	belongs to the nudix hydrolase family
E6C67_RS13650	COG1056	cytidyltransferase-related domain
E6C67_RS13660	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E6C67_RS13670	COG0754	glutathionylspermidine amidase activity
E6C67_RS13695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E6C67_RS13695	COG1213	nucleotidyl transferase
E6C67_RS13705	COG4589	Belongs to the CDS family
E6C67_RS13720	COG3712	iron ion homeostasis
E6C67_RS13745	COG4172	Belongs to the ABC transporter superfamily
E6C67_RS13750	COG0747	negative chemotaxis
E6C67_RS13760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C67_RS13790	COG3119	arylsulfatase activity
E6C67_RS13815	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS13825	COG1024	Enoyl-CoA hydratase
E6C67_RS13850	COG1917	Cupin 2, conserved barrel domain protein
E6C67_RS13850	COG2207	Transcriptional regulator
E6C67_RS13920	COG3597	protein domain associated with
E6C67_RS13930	COG4615	Cyclic peptide transporter
E6C67_RS14000	COG0784	Response regulator, receiver
E6C67_RS14000	COG2205	protein histidine kinase activity
E6C67_RS14005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_RS14010	COG0765	amino acid transport
E6C67_RS14015	COG1126	abc transporter atp-binding protein
E6C67_RS14035	COG0714	Associated with various cellular activities
E6C67_RS14050	COG0626	cystathionine gamma-synthase activity
E6C67_RS14065	COG4191	Histidine kinase
E6C67_RS14080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_RS14110	COG3772	lysozyme
E6C67_RS14230	COG5484	DNA packaging
E6C67_RS14230	COG3728	DNA packaging
E6C67_RS14240	COG0250	Participates in transcription elongation, termination and antitermination
E6C67_RS14260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E6C67_RS14320	COG2197	response regulator
E6C67_RS14420	COG3723	Recombinational DNA repair protein, rece pathway
E6C67_RS14460	COG0028	Belongs to the TPP enzyme family
E6C67_RS14465	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_RS14475	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E6C67_RS14485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E6C67_RS14505	COG0356	it plays a direct role in the translocation of protons across the membrane
E6C67_RS14515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E6C67_RS14520	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E6C67_RS14525	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E6C67_RS14540	COG2080	2 iron, 2 sulfur cluster binding
E6C67_RS14550	COG1294	oxidase, subunit
E6C67_RS14555	COG1271	oxidase subunit
E6C67_RS14560	COG2095	MarC family integral membrane protein
E6C67_RS14570	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E6C67_RS14570	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E6C67_RS14575	COG4770	biotin carboxylase activity
E6C67_RS14580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E6C67_RS14595	COG2198	Histidine kinase
E6C67_RS14595	COG0784	Response regulator, receiver
E6C67_RS14595	COG0643	Histidine kinase
E6C67_RS14620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E6C67_RS14625	COG0408	coproporphyrinogen oxidase activity
E6C67_RS14655	COG0435	Glutathione S-transferase
E6C67_RS14660	COG0655	NAD(P)H dehydrogenase (quinone) activity
E6C67_RS14665	COG0583	DNA-binding transcription factor activity
E6C67_RS14675	COG2267	carboxylic ester hydrolase activity
E6C67_RS14710	COG1360	Flagellar Motor Protein
E6C67_RS14745	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS14755	COG0542	response to heat
E6C67_RS14785	COG0697	spore germination
E6C67_RS14815	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E6C67_RS14845	COG0745	RESPONSE REGULATOR receiver
E6C67_RS14850	COG2172	sigma factor antagonist activity
E6C67_RS14855	COG5002	protein histidine kinase activity
E6C67_RS14880	COG0795	lipopolysaccharide-transporting ATPase activity
E6C67_RS14895	COG1104	cysteine desulfurase activity
E6C67_RS14920	COG1984	allophanate hydrolase subunit 2
E6C67_RS14925	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E6C67_RS14935	COG4336	lyase activity
E6C67_RS15010	COG2986	histidine ammonia-lyase
E6C67_RS15015	COG0402	S-adenosylhomocysteine deaminase activity
E6C67_RS15020	COG1228	amidohydrolase
E6C67_RS15025	COG2188	Transcriptional regulator
E6C67_RS15035	COG2723	6-phospho-beta-galactosidase activity
E6C67_RS15055	COG1196	nuclear chromosome segregation
E6C67_RS15055	COG0741	lytic transglycosylase activity
E6C67_RS15055	COG0739	heme binding
E6C67_RS15080	COG0583	DNA-binding transcription factor activity
E6C67_RS15100	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E6C67_RS15105	COG3842	ATPase activity
E6C67_RS15110	COG2182	Extracellular solute-binding protein
E6C67_RS15120	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C67_RS15130	COG1917	Cupin 2, conserved barrel domain protein
E6C67_RS15130	COG1396	sequence-specific DNA binding
E6C67_RS15135	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_RS15140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E6C67_RS15145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_RS15185	COG0471	metal ion transport
E6C67_RS15185	COG3273	potassium ion transport
E6C67_RS15215	COG2373	Large extracellular alpha-helical protein
E6C67_RS15230	COG0183	Belongs to the thiolase family
E6C67_RS15235	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C67_RS15235	COG1024	Enoyl-CoA hydratase
E6C67_RS15240	COG1960	acyl-CoA dehydrogenase activity
E6C67_RS15245	COG2197	response regulator
E6C67_RS15250	COG0516	GMP reductase activity
E6C67_RS15250	COG0517	IMP dehydrogenase activity
E6C67_RS15255	COG3047	cAMP biosynthetic process
E6C67_RS15290	COG1196	nuclear chromosome segregation
E6C67_RS15300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E6C67_RS15305	COG2084	Dehydrogenase
E6C67_RS15315	COG0679	Auxin Efflux Carrier
E6C67_RS15325	COG1199	ATP-dependent helicase activity
E6C67_RS15325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E6C67_RS15330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E6C67_RS15340	COG0513	Belongs to the DEAD box helicase family
E6C67_RS15350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_RS15355	COG0174	glutamine synthetase
E6C67_RS15365	COG0546	phosphoglycolate phosphatase activity
E6C67_RS15365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E6C67_RS15370	COG2076	Multidrug Resistance protein
E6C67_RS15390	COG0535	radical SAM domain protein
E6C67_RS15400	COG3842	ATPase activity
E6C67_RS15405	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C67_RS15410	COG1177	transmembrane transport
E6C67_RS15440	COG5002	protein histidine kinase activity
E6C67_RS15470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E6C67_RS15470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E6C67_RS15480	COG0243	molybdopterin cofactor binding
E6C67_RS15495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_RS15515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E6C67_RS15525	COG2271	Major facilitator Superfamily
E6C67_RS15530	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E6C67_RS15530	COG1013	pyruvate-flavodoxin oxidoreductase activity
E6C67_RS15530	COG0674	pyruvate-flavodoxin oxidoreductase activity
E6C67_RS15535	COG0246	Mannitol dehydrogenase
E6C67_RS15545	COG1609	Transcriptional regulator
E6C67_RS15555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E6C67_RS15560	COG1882	Formate acetyltransferase
E6C67_RS15565	COG0837	glucose binding
E6C67_RS15565	COG1737	Transcriptional regulator
E6C67_RS15575	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E6C67_RS15595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E6C67_RS15600	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS15620	COG0800	Aldolase
E6C67_RS15625	COG3734	2-keto-3-deoxy-galactonokinase
E6C67_RS15630	COG1414	Transcriptional regulator
E6C67_RS15645	COG2329	Antibiotic biosynthesis monooxygenase
E6C67_RS15650	COG1741	Belongs to the pirin family
E6C67_RS15660	COG0316	Belongs to the HesB IscA family
E6C67_RS15665	COG2151	metal-sulfur cluster biosynthetic enzyme
E6C67_RS15670	COG0822	iron-sulfur transferase activity
E6C67_RS15675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E6C67_RS15680	COG0719	Fe-S assembly protein
E6C67_RS15685	COG0396	ATPase activity
E6C67_RS15690	COG2827	Endonuclease containing a URI domain
E6C67_RS15695	COG0719	Fe-S assembly protein
E6C67_RS15745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E6C67_RS15750	COG0840	transmembrane signaling receptor activity
E6C67_RS15755	COG1475	DNA binding
E6C67_RS15760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E6C67_RS15765	COG1959	2 iron, 2 sulfur cluster binding
E6C67_RS15770	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS15775	COG3385	transposase activity
E6C67_RS15780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E6C67_RS15785	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E6C67_RS15800	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E6C67_RS15850	COG2207	Transcriptional regulator
E6C67_RS15865	COG1566	PFAM secretion protein HlyD family protein
E6C67_RS15870	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS15885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E6C67_RS15890	COG1024	Enoyl-CoA hydratase
E6C67_RS15915	COG2814	Major facilitator Superfamily
E6C67_RS15920	COG2207	Transcriptional regulator
E6C67_RS15925	COG1522	sequence-specific DNA binding
E6C67_RS15940	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E6C67_RS15965	COG2610	gluconate transmembrane transporter activity
E6C67_RS16000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_RS16005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_RS16010	COG0765	amino acid transport
E6C67_RS16015	COG4584	PFAM Integrase catalytic
E6C67_RS16015	COG2390	Transcriptional regulator
E6C67_RS16020	COG1484	DNA-dependent DNA replication
E6C67_RS16045	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E6C67_RS16050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E6C67_RS16095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E6C67_RS16100	COG1657	PFAM Prenyltransferase squalene oxidase
E6C67_RS16105	COG1562	ergosterol biosynthetic process
E6C67_RS16110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C67_RS16150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E6C67_RS16180	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
E6C67_RS16190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_RS16195	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E6C67_RS16225	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E6C67_RS16235	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
E6C67_RS16240	COG2814	Major facilitator Superfamily
E6C67_RS16260	COG4566	intracellular signal transduction
E6C67_RS16265	COG4566	intracellular signal transduction
E6C67_RS16330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_RS16340	COG3384	dioxygenase
E6C67_RS16360	COG0411	ABC transporter
E6C67_RS16375	COG0683	leucine binding
E6C67_RS16385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E6C67_RS16400	COG4191	Histidine kinase
E6C67_RS16405	COG4566	intracellular signal transduction
E6C67_RS16410	COG4566	intracellular signal transduction
E6C67_RS16440	COG0668	transmembrane transport
E6C67_RS16450	COG0583	DNA-binding transcription factor activity
E6C67_RS16455	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS16460	COG3959	Transketolase, thiamine diphosphate binding domain
E6C67_RS16465	COG3958	Transketolase
E6C67_RS16470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_RS16475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_RS16480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_RS16485	COG2084	Dehydrogenase
E6C67_RS16490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E6C67_RS16510	COG0346	lactoylglutathione lyase activity
E6C67_RS16515	COG3474	cytochrome
E6C67_RS16520	COG3385	transposase activity
E6C67_RS16560	COG0459	protein refolding
E6C67_RS16575	COG2188	Transcriptional regulator
E6C67_RS16625	COG3976	FMN-binding domain protein
E6C67_RS16625	COG1053	succinate dehydrogenase
E6C67_RS16630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E6C67_RS16635	COG0066	3-isopropylmalate dehydratase activity
E6C67_RS16645	COG0366	Alpha amylase catalytic
E6C67_RS16665	COG1131	(ABC) transporter
E6C67_RS16675	COG0515	serine threonine protein kinase
E6C67_RS16675	COG2815	serine threonine protein kinase
E6C67_RS16680	COG2116	formate transmembrane transporter activity
E6C67_RS16700	COG0438	transferase activity, transferring glycosyl groups
E6C67_RS16715	COG0438	transferase activity, transferring glycosyl groups
E6C67_RS16735	COG0489	protein tyrosine kinase activity
E6C67_RS16735	COG3206	protein involved in exopolysaccharide biosynthesis
E6C67_RS16755	COG1609	Transcriptional regulator
E6C67_RS16760	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C67_RS16760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C67_RS16765	COG1105	Belongs to the carbohydrate kinase PfkB family
E6C67_RS16770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E6C67_RS16770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E6C67_RS16805	COG0583	DNA-binding transcription factor activity
E6C67_RS16810	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E6C67_RS16815	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E6C67_RS16840	COG2132	Multicopper oxidase
E6C67_RS16855	COG4191	Histidine kinase
E6C67_RS16855	COG0784	Response regulator, receiver
E6C67_RS16860	COG3180	Ammonia monooxygenase
E6C67_RS16875	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS16880	COG1960	acyl-CoA dehydrogenase activity
E6C67_RS16890	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_RS16900	COG1233	COG1233 Phytoene dehydrogenase and related
E6C67_RS16920	COG3956	TIGRFAM MazG family protein
E6C67_RS16935	COG1566	PFAM secretion protein HlyD family protein
E6C67_RS16990	COG0375	protein maturation
E6C67_RS16995	COG2204	response regulator
E6C67_RS17005	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E6C67_RS17015	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
E6C67_RS17025	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E6C67_RS17035	COG0659	secondary active sulfate transmembrane transporter activity
E6C67_RS17045	COG1755	Isoprenylcysteine carboxyl methyltransferase
E6C67_RS17050	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS17055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_RS17065	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_RS17065	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E6C67_RS17075	COG0028	Belongs to the TPP enzyme family
E6C67_RS17095	COG4566	intracellular signal transduction
E6C67_RS17135	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E6C67_RS17140	COG1522	sequence-specific DNA binding
E6C67_RS17145	COG2271	Major facilitator Superfamily
E6C67_RS17150	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS17160	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E6C67_RS17160	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E6C67_RS17175	COG0564	pseudouridine synthase activity
E6C67_RS17180	COG0784	Response regulator, receiver
E6C67_RS17180	COG2205	protein histidine kinase activity
E6C67_RS17185	COG1741	Belongs to the pirin family
E6C67_RS17190	COG3768	UPF0283 membrane protein
E6C67_RS17195	COG3106	COG3106 Predicted ATPase
E6C67_RS17220	COG0297	glycogen (starch) synthase activity
E6C67_RS17260	COG2342	PFAM TM1410 hypothetical-related protein
E6C67_RS17265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C67_RS17280	COG0521	Mo-molybdopterin cofactor biosynthetic process
E6C67_RS17290	COG0714	Associated with various cellular activities
E6C67_RS17295	COG3256	nitric oxide reductase
E6C67_RS17305	COG1845	cytochrome c oxidase, subunit III
E6C67_RS17320	COG3483	tryptophan 2,3-dioxygenase activity
E6C67_RS17330	COG1448	Aminotransferase
E6C67_RS17340	COG3012	SEC-C Motif Domain Protein
E6C67_RS17345	COG2770	Histidine kinase
E6C67_RS17345	COG3437	response regulator, receiver
E6C67_RS17395	COG2358	TRAP transporter, solute receptor (TAXI family
E6C67_RS17430	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E6C67_RS17435	COG2068	MobA-Related Protein
E6C67_RS17440	COG0505	Belongs to the CarA family
E6C67_RS17445	COG0737	Belongs to the 5'-nucleotidase family
E6C67_RS17470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E6C67_RS17475	COG3437	response regulator, receiver
E6C67_RS17475	COG0784	Response regulator, receiver
E6C67_RS17480	COG0747	negative chemotaxis
E6C67_RS17500	COG4176	ABC-type proline glycine betaine transport system permease component
E6C67_RS17505	COG4175	Glycine betaine
E6C67_RS17510	COG0183	Belongs to the thiolase family
E6C67_RS17515	COG1024	Enoyl-CoA hydratase
E6C67_RS17520	COG0477	Major facilitator Superfamily
E6C67_RS17525	COG1595	DNA-templated transcription, initiation
E6C67_RS17530	COG3806	Anti-sigma factor
E6C67_RS17540	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS17545	COG1024	Enoyl-CoA hydratase
E6C67_RS17545	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C67_RS17585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E6C67_RS17655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E6C67_RS17665	COG1737	Transcriptional regulator
E6C67_RS17695	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
E6C67_RS17715	COG1335	isochorismatase
E6C67_RS17720	COG1732	Glycine betaine
E6C67_RS17725	COG1174	glycine betaine transport
E6C67_RS17730	COG1125	glycine betaine transport
E6C67_RS17735	COG1174	glycine betaine transport
E6C67_RS17740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E6C67_RS17745	COG0022	dehydrogenase e1 component
E6C67_RS17755	COG3008	intermembrane lipid transfer
E6C67_RS17760	COG2995	paraquat-inducible protein a
E6C67_RS17765	COG2188	Transcriptional regulator
E6C67_RS17775	COG0765	amino acid transport
E6C67_RS17780	COG0765	amino acid transport
E6C67_RS17785	COG1126	abc transporter atp-binding protein
E6C67_RS17790	COG4115	mRNA cleavage
E6C67_RS17795	COG2161	toxin-antitoxin pair type II binding
E6C67_RS17800	COG1122	ATPase activity
E6C67_RS17805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E6C67_RS17810	COG1268	BioY protein
E6C67_RS17815	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS17820	COG0183	Belongs to the thiolase family
E6C67_RS17835	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E6C67_RS17865	COG5002	protein histidine kinase activity
E6C67_RS17865	COG0784	Response regulator, receiver
E6C67_RS17870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E6C67_RS17875	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E6C67_RS17890	COG0659	secondary active sulfate transmembrane transporter activity
E6C67_RS17920	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E6C67_RS17925	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E6C67_RS17935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E6C67_RS17940	COG0142	geranyltranstransferase activity
E6C67_RS17950	COG0123	including yeast histone deacetylase and acetoin utilization protein
E6C67_RS17960	COG0640	Transcriptional regulator
E6C67_RS17965	COG2363	Small membrane protein
E6C67_RS17980	COG5001	Diguanylate cyclase
E6C67_RS17980	COG5002	protein histidine kinase activity
E6C67_RS18010	COG0154	amidase activity
E6C67_RS18015	COG4178	(ABC) transporter
E6C67_RS18045	COG5489	Protein of unknown function (DUF736)
E6C67_RS18135	COG3451	type IV secretory pathway VirB4
E6C67_RS18195	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E6C67_RS18250	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E6C67_RS18260	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS18270	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS18285	COG1309	transcriptional regulator
E6C67_RS18295	COG4447	cellulose binding
E6C67_RS18330	COG1024	Enoyl-CoA hydratase
E6C67_RS18335	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C67_RS18340	COG0183	Belongs to the thiolase family
E6C67_RS18385	COG0589	response to stress
E6C67_RS18390	COG0386	Belongs to the glutathione peroxidase family
E6C67_RS18395	COG1733	regulation of RNA biosynthetic process
E6C67_RS18400	COG0702	epimerase
E6C67_RS18425	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS18455	COG0179	Fumarylacetoacetate (FAA) hydrolase
E6C67_RS18475	COG0604	alcohol dehydrogenase
E6C67_RS18570	COG0508	dehydrogenase complex catalyzes the overall conversion of
E6C67_RS18575	COG0022	dehydrogenase e1 component
E6C67_RS18575	COG0508	dehydrogenase complex catalyzes the overall conversion of
E6C67_RS18580	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E6C67_RS18585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C67_RS18595	COG0071	Belongs to the small heat shock protein (HSP20) family
E6C67_RS18625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E6C67_RS18660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C67_RS18660	COG0574	Belongs to the PEP-utilizing enzyme family
E6C67_RS18665	COG2249	NAD(P)H dehydrogenase (quinone) activity
E6C67_RS18680	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS18685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E6C67_RS18715	COG1984	allophanate hydrolase subunit 2
E6C67_RS18720	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E6C67_RS18725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_RS18740	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C67_RS18760	COG4172	Belongs to the ABC transporter superfamily
E6C67_RS18765	COG0747	negative chemotaxis
E6C67_RS18775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C67_RS18785	COG2362	D-Aminopeptidase
E6C67_RS18790	COG1446	asparaginase
E6C67_RS18815	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E6C67_RS18840	COG3385	transposase activity
E6C67_RS18845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_RS18855	COG5383	Protein conserved in bacteria
E6C67_RS18860	COG3706	GGDEF domain
E6C67_RS18860	COG5001	Diguanylate cyclase
E6C67_RS18860	COG2203	Gaf domain
E6C67_RS18860	COG4251	negative regulation of phosphorylation
E6C67_RS18880	COG2814	Major facilitator Superfamily
E6C67_RS18885	COG0798	PFAM Bile acid sodium symporter
E6C67_RS18925	COG2133	pyrroloquinoline quinone binding
E6C67_RS18935	COG0459	protein refolding
E6C67_RS18940	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E6C67_RS18955	COG1063	alcohol dehydrogenase
E6C67_RS18995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E6C67_RS19000	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E6C67_RS19005	COG2080	2 iron, 2 sulfur cluster binding
E6C67_RS19015	COG0395	ABC-type sugar transport system, permease component
E6C67_RS19020	COG1175	transmembrane transport
E6C67_RS19025	COG0363	glucosamine-6-phosphate deaminase activity
E6C67_RS19030	COG0673	inositol 2-dehydrogenase activity
E6C67_RS19035	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C67_RS19040	COG1840	ABC-type Fe3 transport system, periplasmic component
E6C67_RS19045	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E6C67_RS19050	COG3842	ATPase activity
E6C67_RS19055	COG1177	transmembrane transport
E6C67_RS19060	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C67_RS19070	COG1609	Transcriptional regulator
E6C67_RS19090	COG2153	protein acetylation
E6C67_RS19100	COG2116	formate transmembrane transporter activity
E6C67_RS19110	COG5001	Diguanylate cyclase
E6C67_RS19115	COG0784	Response regulator, receiver
E6C67_RS19115	COG3437	response regulator, receiver
E6C67_RS19120	COG0469	pyruvate kinase activity
E6C67_RS19190	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E6C67_RS19195	COG2204	response regulator
E6C67_RS19200	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E6C67_RS19205	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C67_RS19215	COG1766	The M ring may be actively involved in energy transduction
E6C67_RS19220	COG1396	sequence-specific DNA binding
E6C67_RS19245	COG1253	flavin adenine dinucleotide binding
E6C67_RS19265	COG0784	Response regulator, receiver
E6C67_RS19265	COG2198	Histidine kinase
E6C67_RS19265	COG5002	protein histidine kinase activity
E6C67_RS19275	COG2030	dehydratase
E6C67_RS19275	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_RS19285	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E6C67_RS19295	COG0840	transmembrane signaling receptor activity
E6C67_RS19315	COG0745	RESPONSE REGULATOR receiver
E6C67_RS19320	COG5002	protein histidine kinase activity
E6C67_RS19320	COG0784	Response regulator, receiver
E6C67_RS19325	COG1363	Peptidase, m42
E6C67_RS19330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E6C67_RS19330	COG0189	ligase activity
E6C67_RS19335	COG0367	asparagine synthase
E6C67_RS19340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C67_RS19350	COG3791	Glutathione-dependent formaldehyde-activating
E6C67_RS19355	COG2080	2 iron, 2 sulfur cluster binding
E6C67_RS19360	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E6C67_RS19365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E6C67_RS19370	COG3385	transposase activity
E6C67_RS19385	COG1840	ABC-type Fe3 transport system, periplasmic component
E6C67_RS19400	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E6C67_RS19435	COG3707	response regulator
E6C67_RS19445	COG1846	Transcriptional regulator
E6C67_RS19450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E6C67_RS19460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_RS19475	COG2226	methyltransferase
E6C67_RS19530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E6C67_RS19540	COG4208	sulfate ABC transporter
E6C67_RS19545	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E6C67_RS19570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E6C67_RS19575	COG0367	asparagine synthase
E6C67_RS19580	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS19595	COG0438	transferase activity, transferring glycosyl groups
E6C67_RS19600	COG0438	transferase activity, transferring glycosyl groups
E6C67_RS19605	COG1216	Glycosyl transferase, family 2
E6C67_RS19625	COG1045	serine acetyltransferase
E6C67_RS19630	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
E6C67_RS19645	COG3206	protein involved in exopolysaccharide biosynthesis
E6C67_RS19645	COG0489	protein tyrosine kinase activity
E6C67_RS19655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E6C67_RS19660	COG0588	phosphoglycerate mutase activity
E6C67_RS19675	COG5002	protein histidine kinase activity
E6C67_RS19690	COG2089	acid synthase
E6C67_RS19695	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
E6C67_RS19715	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS19720	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS19725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E6C67_RS19740	COG0457	Tetratricopeptide repeat
E6C67_RS19740	COG0859	PFAM glycosyl transferase family 9
E6C67_RS19755	COG0457	Tetratricopeptide repeat
E6C67_RS19755	COG0859	PFAM glycosyl transferase family 9
E6C67_RS19760	COG2226	methyltransferase
E6C67_RS19785	COG1558	bacterial-type flagellum-dependent cell motility
E6C67_RS19800	COG0366	Alpha amylase catalytic
E6C67_RS19805	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E6C67_RS19820	COG1749	Flagellar hook protein flgE
E6C67_RS19820	COG1749	Flagellar hook protein flgE
E6C67_RS19845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_RS19845	COG4191	Histidine kinase
E6C67_RS19850	COG0737	Belongs to the 5'-nucleotidase family
E6C67_RS19860	COG3385	transposase activity
E6C67_RS19875	COG0625	glutathione transferase activity
E6C67_RS19885	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS19920	COG1024	Enoyl-CoA hydratase
E6C67_RS19945	COG1640	4-alpha-glucanotransferase
E6C67_RS19965	COG4191	Histidine kinase
E6C67_RS19970	COG1301	dicarboxylic acid transport
E6C67_RS19975	COG0280	phosphate acetyltransferase
E6C67_RS19975	COG0281	malic enzyme
E6C67_RS19985	COG0859	PFAM glycosyl transferase family 9
E6C67_RS19985	COG0457	Tetratricopeptide repeat
E6C67_RS20000	COG4520	surface antigen
E6C67_RS20005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C67_RS20040	COG2847	Copper chaperone PCu(A)C
E6C67_RS20055	COG0784	Response regulator, receiver
E6C67_RS20060	COG3920	Histidine kinase
E6C67_RS20060	COG2202	Pas domain
E6C67_RS20065	COG0784	Response regulator, receiver
E6C67_RS20070	COG4251	negative regulation of phosphorylation
E6C67_RS20095	COG2183	response to ionizing radiation
E6C67_RS20100	COG1280	lysine exporter protein (LysE YggA)
E6C67_RS20130	COG0393	Putative heavy-metal-binding
E6C67_RS20135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E6C67_RS20155	COG1309	transcriptional regulator
E6C67_RS20160	COG3706	GGDEF domain
E6C67_RS20165	COG0772	Belongs to the SEDS family
E6C67_RS20170	COG2273	Hydrolase Family 16
E6C67_RS20225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_RS20240	COG1131	(ABC) transporter
E6C67_RS20255	COG2169	Transcriptional regulator
E6C67_RS20255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E6C67_RS20285	COG0420	3'-5' exonuclease activity
E6C67_RS20310	COG0805	protein transport
E6C67_RS20315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E6C67_RS20320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E6C67_RS20325	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E6C67_RS20330	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E6C67_RS20335	COG1994	Peptidase M50
E6C67_RS20355	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E6C67_RS20360	COG0316	Belongs to the HesB IscA family
E6C67_RS20395	COG0308	aminopeptidase N
E6C67_RS20415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E6C67_RS20430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C67_RS20445	COG0463	Glycosyl transferase, family 2
E6C67_RS20450	COG0740	serine-type endopeptidase activity
E6C67_RS20500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E6C67_RS20505	COG2010	Cytochrome c
E6C67_RS20505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E6C67_RS20540	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS20550	COG0697	spore germination
E6C67_RS20560	COG3411	Ferredoxin
E6C67_RS20565	COG4603	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS20570	COG1079	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS20575	COG0295	cytidine deaminase activity
E6C67_RS20580	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E6C67_RS20585	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E6C67_RS20590	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E6C67_RS20615	COG3546	catalase activity
E6C67_RS20620	COG2223	nitrite transmembrane transporter activity
E6C67_RS20625	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E6C67_RS20650	COG1177	transmembrane transport
E6C67_RS20655	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C67_RS20660	COG3842	ATPase activity
E6C67_RS20665	COG1414	Transcriptional regulator
E6C67_RS20680	COG3845	ABC transporter
E6C67_RS20685	COG4603	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS20690	COG1079	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS20695	COG0402	S-adenosylhomocysteine deaminase activity
E6C67_RS20700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E6C67_RS20710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E6C67_RS20730	COG2814	Major facilitator Superfamily
E6C67_RS20750	COG2217	Heavy metal translocating P-type atpase
E6C67_RS20760	COG2860	membrane
E6C67_RS20780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E6C67_RS20800	COG0142	geranyltranstransferase activity
E6C67_RS20810	COG2890	protein-(glutamine-N5) methyltransferase activity
E6C67_RS20835	COG1666	GTP binding
E6C67_RS20840	COG4608	Belongs to the ABC transporter superfamily
E6C67_RS20845	COG0444	Belongs to the ABC transporter superfamily
E6C67_RS20850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C67_RS20855	COG0601	transmembrane transport
E6C67_RS20860	COG0747	negative chemotaxis
E6C67_RS20865	COG0697	spore germination
E6C67_RS20885	COG0784	Response regulator, receiver
E6C67_RS20900	COG0860	N-Acetylmuramoyl-L-alanine amidase
E6C67_RS20915	COG0604	alcohol dehydrogenase
E6C67_RS20915	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS20915	COG3321	synthase
E6C67_RS20920	COG1414	Transcriptional regulator
E6C67_RS20925	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E6C67_RS20930	COG0045	succinate-CoA ligase (ADP-forming) activity
E6C67_RS20935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_RS20945	COG1802	Transcriptional regulator
E6C67_RS20950	COG1414	Transcriptional regulator
E6C67_RS20960	COG4221	oxidoreductase activity
E6C67_RS20970	COG3960	tartronate-semialdehyde synthase activity
E6C67_RS20975	COG2351	hydroxyisourate hydrolase activity
E6C67_RS21010	COG0517	IMP dehydrogenase activity
E6C67_RS21015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E6C67_RS21040	COG0517	IMP dehydrogenase activity
E6C67_RS21050	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C67_RS21050	COG0574	Belongs to the PEP-utilizing enzyme family
E6C67_RS21070	COG1802	Transcriptional regulator
E6C67_RS21075	COG0352	thiamine-phosphate diphosphorylase activity
E6C67_RS21115	COG0546	phosphoglycolate phosphatase activity
E6C67_RS21135	COG3547	Transposase (IS116 IS110 IS902 family)
E6C67_RS21145	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_RS21160	COG4584	PFAM Integrase catalytic
E6C67_RS21165	COG1484	DNA-dependent DNA replication
E6C67_RS21220	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E6C67_RS21235	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C67_RS21245	COG0728	peptidoglycan biosynthetic process
E6C67_RS21250	COG0596	Alpha beta hydrolase
E6C67_RS21255	COG0148	phosphopyruvate hydratase activity
E6C67_RS21270	COG0678	peroxiredoxin activity
E6C67_RS21295	COG3243	poly(R)-hydroxyalkanoic acid synthase
E6C67_RS21300	COG0515	serine threonine protein kinase
E6C67_RS21300	COG4991	sh3 domain protein
E6C67_RS21300	COG3064	Membrane
E6C67_RS21310	COG1902	pentaerythritol trinitrate reductase activity
E6C67_RS21340	COG0640	Transcriptional regulator
E6C67_RS21355	COG0640	Transcriptional regulator
E6C67_RS21365	COG0446	pyridine nucleotide-disulphide oxidoreductase
E6C67_RS21375	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS21390	COG0683	leucine binding
E6C67_RS21415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C67_RS21420	COG1309	transcriptional regulator
E6C67_RS21425	COG0840	transmembrane signaling receptor activity
E6C67_RS21435	COG2205	protein histidine kinase activity
E6C67_RS21450	COG2264	protein methyltransferase activity
E6C67_RS21490	COG4770	biotin carboxylase activity
E6C67_RS21495	COG1024	Enoyl-CoA hydratase
E6C67_RS21500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E6C67_RS21505	COG1960	acyl-CoA dehydrogenase activity
E6C67_RS21510	COG0183	Belongs to the thiolase family
E6C67_RS21515	COG1960	acyl-CoA dehydrogenase activity
E6C67_RS21540	COG0784	Response regulator, receiver
E6C67_RS21540	COG2205	protein histidine kinase activity
E6C67_RS21575	COG2902	Dehydrogenase
E6C67_RS21605	COG1192	Involved in chromosome partitioning
E6C67_RS21610	COG1475	DNA binding
E6C67_RS21615	COG3385	transposase activity
E6C67_RS21620	COG0747	negative chemotaxis
E6C67_RS21630	COG2205	protein histidine kinase activity
E6C67_RS21630	COG2198	Histidine kinase
E6C67_RS21630	COG0784	Response regulator, receiver
E6C67_RS21635	COG2202	Pas domain
E6C67_RS21635	COG2205	protein histidine kinase activity
E6C67_RS21690	COG0583	DNA-binding transcription factor activity
E6C67_RS21705	COG3383	formate dehydrogenase (NAD+) activity
E6C67_RS21710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E6C67_RS21755	COG0411	ABC transporter
E6C67_RS21780	COG0625	glutathione transferase activity
E6C67_RS21785	COG0583	DNA-binding transcription factor activity
E6C67_RS21790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E6C67_RS21810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E6C67_RS21815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E6C67_RS21820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E6C67_RS21825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E6C67_RS21830	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E6C67_RS21830	COG2885	chlorophyll binding
E6C67_RS21850	COG0366	Alpha amylase catalytic
E6C67_RS21855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E6C67_RS21875	COG0745	RESPONSE REGULATOR receiver
E6C67_RS21880	COG1640	4-alpha-glucanotransferase
E6C67_RS21905	COG4453	Protein conserved in bacteria
E6C67_RS21920	COG4227	nucleotidyltransferase activity
E6C67_RS21975	COG1247	-acetyltransferase
E6C67_RS21980	COG0519	Catalyzes the synthesis of GMP from XMP
E6C67_RS21980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E6C67_RS22020	COG1914	H( )-stimulated, divalent metal cation uptake system
E6C67_RS22025	COG2900	Belongs to the SlyX family
E6C67_RS22030	COG1160	GTP binding
E6C67_RS22045	COG2197	response regulator
E6C67_RS22055	COG0840	transmembrane signaling receptor activity
E6C67_RS22055	COG3290	protein histidine kinase activity
E6C67_RS22060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E6C67_RS22115	COG0604	alcohol dehydrogenase
E6C67_RS22115	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS22115	COG3321	synthase
E6C67_RS22125	COG0163	prenyltransferase activity
E6C67_RS22130	COG0288	reversible hydration of carbon dioxide
E6C67_RS22155	COG0205	6-phosphofructokinase activity
E6C67_RS22170	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E6C67_RS22175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E6C67_RS22190	COG5001	Diguanylate cyclase
E6C67_RS22210	COG0114	fumarate hydratase activity
E6C67_RS22235	COG2951	lytic endotransglycosylase activity
E6C67_RS22275	COG4191	Histidine kinase
E6C67_RS22285	COG3385	transposase activity
E6C67_RS22290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C67_RS22295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_RS22315	COG1366	Belongs to the anti-sigma-factor antagonist family
E6C67_RS22320	COG2208	phosphoserine phosphatase activity
E6C67_RS22320	COG2770	Histidine kinase
E6C67_RS22445	COG0500	methyltransferase
E6C67_RS22470	COG2815	serine threonine protein kinase
E6C67_RS22470	COG0515	serine threonine protein kinase
E6C67_RS22490	COG0745	RESPONSE REGULATOR receiver
E6C67_RS22510	COG0105	UTP biosynthetic process
E6C67_RS22520	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E6C67_RS22525	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_RS22530	COG0488	(ABC) transporter
E6C67_RS22535	COG3932	Exopolysaccharide synthesis, ExoD
E6C67_RS22560	COG1686	Belongs to the peptidase S11 family
E6C67_RS22565	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E6C67_RS22570	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E6C67_RS22575	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E6C67_RS22580	COG0084	hydrolase, TatD family'
E6C67_RS22585	COG0321	lipoyl(octanoyl) transferase activity
E6C67_RS22585	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E6C67_RS22590	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E6C67_RS22620	COG1381	Involved in DNA repair and RecF pathway recombination
E6C67_RS22625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E6C67_RS22650	COG4786	Flagellar basal body rod
E6C67_RS22655	COG4786	Flagellar basal body rod
E6C67_RS22665	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E6C67_RS22690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E6C67_RS22690	COG4651	solute:proton antiporter activity
E6C67_RS22745	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E6C67_RS22755	COG1024	Enoyl-CoA hydratase
E6C67_RS22760	COG0758	DNA mediated transformation
E6C67_RS22765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E6C67_RS22770	COG1024	Enoyl-CoA hydratase
E6C67_RS22775	COG1832	CoA-binding protein
E6C67_RS22780	COG2873	o-acetylhomoserine
E6C67_RS22810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E6C67_RS22840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E6C67_RS22860	COG5001	Diguanylate cyclase
E6C67_RS22860	COG3447	MASE1 domain protein
E6C67_RS22860	COG5002	protein histidine kinase activity
E6C67_RS22880	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E6C67_RS22895	COG1238	metal cluster binding
E6C67_RS22900	COG0203	ribosomal protein L17
E6C67_RS22915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E6C67_RS22930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E6C67_RS22935	COG0251	oxidation-reduction process
E6C67_RS22995	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E6C67_RS22995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E6C67_RS23030	COG0154	amidase activity
E6C67_RS23035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E6C67_RS23045	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E6C67_RS23055	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E6C67_RS23080	COG0242	peptide deformylase activity
E6C67_RS23085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E6C67_RS23090	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E6C67_RS23095	COG1201	RNA secondary structure unwinding
E6C67_RS23105	COG0415	Belongs to the DNA photolyase family
E6C67_RS23110	COG0735	belongs to the Fur family
E6C67_RS23115	COG0523	cobalamin synthesis protein
E6C67_RS23130	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E6C67_RS23145	COG2205	protein histidine kinase activity
E6C67_RS23155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E6C67_RS23160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E6C67_RS23160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E6C67_RS23175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E6C67_RS23175	COG0357	Ribosomal RNA small subunit methyltransferase G
E6C67_RS23180	COG4251	negative regulation of phosphorylation
E6C67_RS23185	COG0494	nUDIX hydrolase
E6C67_RS23195	COG0497	DNA recombination
E6C67_RS23200	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E6C67_RS23220	COG0006	proline dipeptidase activity
E6C67_RS23230	COG2264	protein methyltransferase activity
E6C67_RS23240	COG0210	DNA helicase
E6C67_RS23245	COG2197	response regulator
E6C67_RS23250	COG2197	response regulator
E6C67_RS23280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E6C67_RS23295	COG2910	NAD(P)H-binding
E6C67_RS23305	COG0366	Alpha amylase catalytic
E6C67_RS23320	COG0742	ribosomal rna small subunit methyltransferase
E6C67_RS23325	COG1187	pseudouridine synthase activity
E6C67_RS23330	COG0590	tRNA wobble adenosine to inosine editing
E6C67_RS23340	COG1895	HEPN domain
E6C67_RS23355	COG1570	exodeoxyribonuclease VII activity
E6C67_RS23360	COG0418	dihydroorotase activity
E6C67_RS23410	COG3300	MHYT domain
E6C67_RS23410	COG5001	Diguanylate cyclase
E6C67_RS23415	COG1283	sodium-dependent phosphate transmembrane transporter activity
E6C67_RS23420	COG0012	GTP binding
E6C67_RS23425	COG0193	aminoacyl-tRNA hydrolase activity
E6C67_RS23430	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E6C67_RS23455	COG2945	thiolester hydrolase activity
E6C67_RS23460	COG1045	serine acetyltransferase
E6C67_RS23475	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E6C67_RS23485	COG0482	sulfurtransferase activity
E6C67_RS23505	COG3284	Transcriptional regulator
E6C67_RS23515	COG0456	acetyltransferase
E6C67_RS23530	COG0488	(ABC) transporter
E6C67_RS23535	COG0697	spore germination
E6C67_RS23540	COG3023	N-Acetylmuramoyl-L-alanine amidase
E6C67_RS23550	COG2001	Belongs to the MraZ family
E6C67_RS23570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E6C67_RS23580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E6C67_RS23585	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E6C67_RS23595	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E6C67_RS23605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E6C67_RS23610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E6C67_RS23615	COG1181	Belongs to the D-alanine--D-alanine ligase family
E6C67_RS23620	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E6C67_RS23625	COG0849	cell division
E6C67_RS23630	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E6C67_RS23670	COG0248	Ppx GppA phosphatase
E6C67_RS23680	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E6C67_RS23690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E6C67_RS23705	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E6C67_RS23765	COG1079	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS23770	COG4603	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS23775	COG3845	ABC transporter
E6C67_RS23795	COG0546	phosphoglycolate phosphatase activity
E6C67_RS23800	COG0564	pseudouridine synthase activity
E6C67_RS23805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E6C67_RS23810	COG1335	isochorismatase
E6C67_RS23825	COG1136	(ABC) transporter
E6C67_RS23835	COG0442	prolyl-tRNA aminoacylation
E6C67_RS23850	COG0519	Catalyzes the synthesis of GMP from XMP
E6C67_RS23860	COG0346	lactoylglutathione lyase activity
E6C67_RS23880	COG1007	ATP synthesis coupled electron transport
E6C67_RS23895	COG0713	ATP synthesis coupled electron transport
E6C67_RS23910	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E6C67_RS23915	COG1034	ATP synthesis coupled electron transport
E6C67_RS23920	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E6C67_RS23925	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E6C67_RS23930	COG0649	NAD binding
E6C67_RS23935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E6C67_RS23940	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E6C67_RS23945	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E6C67_RS24000	COG0492	ferredoxin-NADP+ reductase activity
E6C67_RS24030	COG1484	DNA-dependent DNA replication
E6C67_RS24035	COG4584	PFAM Integrase catalytic
E6C67_RS24035	COG2390	Transcriptional regulator
E6C67_RS24055	COG0500	methyltransferase
E6C67_RS24060	COG0140	phosphoribosyl-ATP diphosphatase activity
E6C67_RS24070	COG2862	Uncharacterized protein family, UPF0114
E6C67_RS24090	COG0768	penicillin binding
E6C67_RS24105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E6C67_RS24115	COG0028	Belongs to the TPP enzyme family
E6C67_RS24120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C67_RS24125	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E6C67_RS24140	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E6C67_RS24155	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E6C67_RS24160	COG0830	nickel cation binding
E6C67_RS24170	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
E6C67_RS24175	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E6C67_RS24180	COG0804	urea catabolic process
E6C67_RS24185	COG0832	Belongs to the urease beta subunit family
E6C67_RS24190	COG0831	urea catabolic process
E6C67_RS24195	COG0829	nickel cation binding
E6C67_RS24200	COG2197	response regulator
E6C67_RS24205	COG2197	response regulator
E6C67_RS24210	COG0693	protein deglycase activity
E6C67_RS24225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E6C67_RS24230	COG0717	Belongs to the dCTP deaminase family
E6C67_RS24250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E6C67_RS24285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E6C67_RS24295	COG0557	exoribonuclease II activity
E6C67_RS24300	COG0793	Belongs to the peptidase S41A family
E6C67_RS24305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E6C67_RS24310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E6C67_RS24330	COG1380	Effector of murein hydrolase LrgA
E6C67_RS24335	COG1346	cytolysis
E6C67_RS24340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E6C67_RS24365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E6C67_RS24395	COG4191	Histidine kinase
E6C67_RS24395	COG0784	Response regulator, receiver
E6C67_RS24415	COG1131	(ABC) transporter
E6C67_RS24425	COG1309	transcriptional regulator
E6C67_RS24445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E6C67_RS24460	COG5554	nitrogen fixation
E6C67_RS24470	COG1104	cysteine desulfurase activity
E6C67_RS24485	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E6C67_RS24515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E6C67_RS24525	COG0745	RESPONSE REGULATOR receiver
E6C67_RS24530	COG2176	DNA-directed DNA polymerase activity
E6C67_RS24530	COG5002	protein histidine kinase activity
E6C67_RS24540	COG5002	protein histidine kinase activity
E6C67_RS24545	COG2204	response regulator
E6C67_RS24550	COG3852	Histidine kinase
E6C67_RS24555	COG2204	response regulator
E6C67_RS24585	COG0519	Catalyzes the synthesis of GMP from XMP
E6C67_RS24600	COG0752	glycyl-tRNA synthetase alpha subunit
E6C67_RS24605	COG0751	glycine-tRNA ligase activity
E6C67_RS24640	COG3437	response regulator, receiver
E6C67_RS24640	COG2770	Histidine kinase
E6C67_RS24645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E6C67_RS24650	COG1234	tRNA 3'-trailer cleavage
E6C67_RS24655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E6C67_RS24660	COG0047	phosphoribosylformylglycinamidine synthase activity
E6C67_RS24665	COG0004	ammonium transporteR
E6C67_RS24670	COG0312	modulator of DNA gyrase
E6C67_RS24690	COG1846	Transcriptional regulator
E6C67_RS24700	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E6C67_RS24730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E6C67_RS24740	COG0463	Glycosyl transferase, family 2
E6C67_RS24760	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
E6C67_RS24765	COG3118	belongs to the thioredoxin family
E6C67_RS24775	COG2835	tetraacyldisaccharide 4'-kinase activity
E6C67_RS24785	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E6C67_RS24800	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS24805	COG0183	Belongs to the thiolase family
E6C67_RS24810	COG3243	poly(R)-hydroxyalkanoic acid synthase
E6C67_RS24815	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
E6C67_RS24850	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
E6C67_RS24860	COG0842	Transport permease protein
E6C67_RS24865	COG1132	(ABC) transporter
E6C67_RS24870	COG0254	rRNA binding
E6C67_RS24880	COG0071	Belongs to the small heat shock protein (HSP20) family
E6C67_RS24895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E6C67_RS24900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E6C67_RS24905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E6C67_RS24915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E6C67_RS24930	COG0793	Belongs to the peptidase S41A family
E6C67_RS24935	COG4942	peptidase
E6C67_RS24940	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E6C67_RS24945	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E6C67_RS24950	COG0799	negative regulation of ribosome biogenesis
E6C67_RS24955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E6C67_RS24970	COG1051	belongs to the nudix hydrolase family
E6C67_RS24980	COG0745	RESPONSE REGULATOR receiver
E6C67_RS24985	COG0643	Histidine kinase
E6C67_RS24985	COG2198	Histidine kinase
E6C67_RS24990	COG0835	chemotaxis
E6C67_RS24995	COG0840	transmembrane signaling receptor activity
E6C67_RS25005	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E6C67_RS25010	COG2201	protein-glutamate methylesterase activity
E6C67_RS25015	COG0840	transmembrane signaling receptor activity
E6C67_RS25020	COG1366	Belongs to the anti-sigma-factor antagonist family
E6C67_RS25040	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E6C67_RS25045	COG0579	oxidoreductase
E6C67_RS25050	COG0071	Belongs to the small heat shock protein (HSP20) family
E6C67_RS25080	COG1322	Protein conserved in bacteria
E6C67_RS25095	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS25100	COG0436	Aminotransferase
E6C67_RS25145	COG1278	Cold shock
E6C67_RS25150	COG1902	pentaerythritol trinitrate reductase activity
E6C67_RS25160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E6C67_RS25180	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E6C67_RS25190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E6C67_RS25195	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E6C67_RS25210	COG0277	FAD linked oxidase domain protein
E6C67_RS25215	COG0009	L-threonylcarbamoyladenylate synthase
E6C67_RS25220	COG1192	Involved in chromosome partitioning
E6C67_RS25230	COG2193	ferroxidase activity
E6C67_RS25245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E6C67_RS25250	COG0747	negative chemotaxis
E6C67_RS25265	COG4191	Histidine kinase
E6C67_RS25270	COG0101	tRNA pseudouridine synthase activity
E6C67_RS25275	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E6C67_RS25280	COG0242	peptide deformylase activity
E6C67_RS25285	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E6C67_RS25305	COG1595	DNA-templated transcription, initiation
E6C67_RS25345	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E6C67_RS25360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_RS25375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C67_RS25390	COG2350	Protein conserved in bacteria
E6C67_RS25410	COG0681	Belongs to the peptidase S26 family
E6C67_RS25415	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E6C67_RS25425	COG2205	protein histidine kinase activity
E6C67_RS25435	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E6C67_RS25460	COG0586	Pfam SNARE associated Golgi protein
E6C67_RS25480	COG1278	Cold shock
E6C67_RS25535	COG3327	negative regulation of DNA-templated transcription, initiation
E6C67_RS25560	COG0840	transmembrane signaling receptor activity
E6C67_RS25570	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E6C67_RS25590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E6C67_RS25610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E6C67_RS25615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E6C67_RS25630	COG0167	dihydroorotate dehydrogenase activity
E6C67_RS25690	COG3385	transposase activity
E6C67_RS25705	COG2032	superoxide dismutase activity
E6C67_RS25715	COG0625	glutathione transferase activity
E6C67_RS25725	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E6C67_RS25735	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E6C67_RS25745	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E6C67_RS25765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E6C67_RS25775	COG4974	Belongs to the 'phage' integrase family
E6C67_RS25780	COG0840	transmembrane signaling receptor activity
E6C67_RS25810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E6C67_RS25830	COG1278	Cold shock
E6C67_RS25840	COG4191	Histidine kinase
E6C67_RS25850	COG4106	trans-aconitate 2-methyltransferase activity
E6C67_RS25865	COG0126	phosphoglycerate kinase activity
E6C67_RS25880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E6C67_RS25885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E6C67_RS25895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E6C67_RS25900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E6C67_RS25910	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E6C67_RS25915	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E6C67_RS25955	COG1546	Belongs to the CinA family
E6C67_RS25955	COG1058	Belongs to the CinA family
E6C67_RS25960	COG1489	DNA binding
E6C67_RS25965	COG0024	Methionine aminopeptidase
E6C67_RS25980	COG0514	ATP-dependent DNA helicase (RecQ)
E6C67_RS25985	COG0494	nUDIX hydrolase
E6C67_RS25990	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E6C67_RS25995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E6C67_RS26000	COG0653	protein targeting
E6C67_RS26005	COG1970	mechanosensitive ion channel activity
E6C67_RS26020	COG0640	Transcriptional regulator
E6C67_RS26025	COG2076	Multidrug Resistance protein
E6C67_RS26045	COG0039	L-malate dehydrogenase activity
E6C67_RS26050	COG0045	succinate-CoA ligase (ADP-forming) activity
E6C67_RS26080	COG4191	Histidine kinase
E6C67_RS26115	COG1643	Atp-dependent helicase
E6C67_RS26135	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E6C67_RS26150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C67_RS26150	COG0574	Belongs to the PEP-utilizing enzyme family
E6C67_RS26155	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
E6C67_RS26160	COG1396	sequence-specific DNA binding
E6C67_RS26165	COG0574	Belongs to the PEP-utilizing enzyme family
E6C67_RS26165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C67_RS26175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E6C67_RS26185	COG0539	negative regulation of cytoplasmic translation
E6C67_RS26240	COG1238	metal cluster binding
E6C67_RS26245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E6C67_RS26255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E6C67_RS26265	COG1674	ftsk spoiiie
E6C67_RS26270	COG2318	DinB family
E6C67_RS26300	COG0243	molybdopterin cofactor binding
E6C67_RS26310	COG3005	denitrification pathway
E6C67_RS26325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E6C67_RS26330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E6C67_RS26345	COG1522	sequence-specific DNA binding
E6C67_RS26350	COG3660	Nucleoside-diphosphate-sugar epimerase
E6C67_RS26395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E6C67_RS26405	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E6C67_RS26415	COG1253	flavin adenine dinucleotide binding
E6C67_RS26430	COG0583	DNA-binding transcription factor activity
E6C67_RS26435	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E6C67_RS26455	COG0138	bifunctional purine biosynthesis protein purh
E6C67_RS26465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E6C67_RS26465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E6C67_RS26475	COG1024	Enoyl-CoA hydratase
E6C67_RS26480	COG0477	Major facilitator Superfamily
E6C67_RS26485	COG0583	DNA-binding transcription factor activity
E6C67_RS26505	COG1272	protein, Hemolysin III
E6C67_RS26540	COG0137	argininosuccinate synthase activity
E6C67_RS26545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E6C67_RS26550	COG0840	transmembrane signaling receptor activity
E6C67_RS26560	COG0783	Belongs to the Dps family
E6C67_RS26590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C67_RS26605	COG0776	regulation of translation
E6C67_RS26615	COG2423	ornithine cyclodeaminase activity
E6C67_RS26795	COG0741	lytic transglycosylase activity
E6C67_RS26945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E6C67_RS26985	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E6C67_RS27000	COG3813	Protein conserved in bacteria
E6C67_RS27005	COG1473	amidohydrolase
E6C67_RS27015	COG5001	Diguanylate cyclase
E6C67_RS27035	COG4106	trans-aconitate 2-methyltransferase activity
E6C67_RS27055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E6C67_RS27075	COG3162	membrane
E6C67_RS27105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E6C67_RS27110	COG0542	response to heat
E6C67_RS27130	COG2890	protein-(glutamine-N5) methyltransferase activity
E6C67_RS27135	COG2852	Protein conserved in bacteria
E6C67_RS27145	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E6C67_RS27150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E6C67_RS27200	COG0739	heme binding
E6C67_RS27220	COG0386	Belongs to the glutathione peroxidase family
E6C67_RS27225	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E6C67_RS27235	COG0569	domain protein
E6C67_RS27235	COG2985	domain, Protein
E6C67_RS27265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E6C67_RS27270	COG0792	nuclease activity
E6C67_RS27285	COG0180	Tryptophanyl-tRNA synthetase
E6C67_RS27290	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E6C67_RS27310	COG0606	chelatase, subunit chli
E6C67_RS27335	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E6C67_RS27345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E6C67_RS27360	COG0730	response to heat
E6C67_RS27375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E6C67_RS27385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E6C67_RS27400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E6C67_RS27420	COG0668	transmembrane transport
E6C67_RS27425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E6C67_RS27435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E6C67_RS27440	COG0302	gtp cyclohydrolase
E6C67_RS27445	COG2967	ApaG domain
E6C67_RS27455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E6C67_RS27460	COG1702	phosphate starvation-inducible protein PhoH
E6C67_RS27470	COG1253	flavin adenine dinucleotide binding
E6C67_RS27475	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E6C67_RS27480	COG1396	sequence-specific DNA binding
E6C67_RS27485	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E6C67_RS27490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E6C67_RS27495	COG0779	Required for maturation of 30S ribosomal subunits
E6C67_RS27520	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E6C67_RS27525	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E6C67_RS27530	COG1185	polyribonucleotide nucleotidyltransferase activity
E6C67_RS27535	COG2378	regulation of single-species biofilm formation
E6C67_RS27550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E6C67_RS27560	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E6C67_RS27565	COG1138	Cytochrome C-type biogenesis protein
E6C67_RS27570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E6C67_RS27575	COG3088	subunit of a heme lyase
E6C67_RS27580	COG4235	cytochrome complex assembly
E6C67_RS27640	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E6C67_RS27645	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E6C67_RS27650	COG4395	Tim44
E6C67_RS27660	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E6C67_RS27665	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E6C67_RS27670	COG1981	membrane
E6C67_RS27705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E6C67_RS27725	COG1331	Highly conserved protein containing a thioredoxin domain
E6C67_RS27745	COG0445	tRNA wobble uridine modification
E6C67_RS27750	COG0357	Ribosomal RNA small subunit methyltransferase G
E6C67_RS27765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E6C67_RS27770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E6C67_RS27775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E6C67_RS27780	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E6C67_RS27785	COG2814	Major facilitator Superfamily
E6C67_RS27790	COG0281	malic enzyme
E6C67_RS27790	COG0280	phosphate acetyltransferase
E6C67_RS27805	COG5002	protein histidine kinase activity
E6C67_RS27810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E6C67_RS27815	COG0573	inorganic phosphate transmembrane transporter activity
E6C67_RS27825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E6C67_RS27830	COG0745	RESPONSE REGULATOR receiver
E6C67_RS27840	COG0670	Belongs to the BI1 family
E6C67_RS27850	COG4181	ATPase activity
E6C67_RS27865	COG0667	Aldo Keto reductase
E6C67_RS27870	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E6C67_RS27875	COG3706	GGDEF domain
E6C67_RS27880	COG0484	heat shock protein binding
E6C67_RS27885	COG0443	Heat shock 70 kDa protein
E6C67_RS27905	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E6C67_RS27925	COG4957	zinc ion binding
E6C67_RS27975	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E6C67_RS27985	COG0745	RESPONSE REGULATOR receiver
E6C67_RS27990	COG0642	Histidine kinase
E6C67_RS28010	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C67_RS28010	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E6C67_RS28020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C67_RS28040	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E6C67_RS28070	COG0271	Belongs to the BolA IbaG family
E6C67_RS28095	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E6C67_RS28115	COG4974	Belongs to the 'phage' integrase family
E6C67_RS28125	COG2154	pterin-4-alpha-carbinolamine dehydratase
E6C67_RS28135	COG1573	uracil-dna glycosylase
E6C67_RS28145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E6C67_RS28150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C67_RS28165	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C67_RS28170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E6C67_RS28175	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E6C67_RS28205	COG2223	nitrite transmembrane transporter activity
E6C67_RS28235	COG0517	IMP dehydrogenase activity
E6C67_RS28235	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E6C67_RS28250	COG1137	ATPase activity
E6C67_RS28255	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E6C67_RS28260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E6C67_RS28265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C67_RS28270	COG4636	protein conserved in cyanobacteria
E6C67_RS28280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E6C67_RS28285	COG0527	aspartate kinase activity
E6C67_RS28290	COG2070	2-Nitropropane dioxygenase
E6C67_RS28335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E6C67_RS28360	COG0501	Belongs to the peptidase M48B family
E6C67_RS28365	COG3258	Cytochrome c
E6C67_RS28375	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E6C67_RS28400	COG3118	belongs to the thioredoxin family
E6C67_RS28405	COG1074	ATP-dependent DNA helicase activity
E6C67_RS28420	COG2887	Belongs to the helicase family. UvrD subfamily
E6C67_RS28425	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E6C67_RS28435	COG0802	atpase or kinase
E6C67_RS28450	COG2205	protein histidine kinase activity
E6C67_RS28465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E6C67_RS28470	COG2204	response regulator
E6C67_RS28475	COG1278	Cold shock
E6C67_RS28480	COG0784	Response regulator, receiver
E6C67_RS28480	COG2205	protein histidine kinase activity
E6C67_RS28485	COG0133	tryptophan synthase activity
E6C67_RS28495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E6C67_RS28500	COG0285	dihydrofolate synthase activity
E6C67_RS28505	COG1715	Restriction endonuclease
E6C67_RS28520	COG1872	DUF167
E6C67_RS28525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E6C67_RS28530	COG0598	Magnesium transport protein CorA
E6C67_RS28540	COG0039	L-malate dehydrogenase activity
E6C67_RS28555	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E6C67_RS28560	COG4166	transmembrane transport
E6C67_RS28565	COG0747	negative chemotaxis
E6C67_RS28575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C67_RS28590	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E6C67_RS28625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E6C67_RS28635	COG1024	Enoyl-CoA hydratase
E6C67_RS28640	COG0268	Binds directly to 16S ribosomal RNA
E6C67_RS28645	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E6C67_RS28650	COG3706	GGDEF domain
E6C67_RS28655	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E6C67_RS28660	COG3842	ATPase activity
E6C67_RS28670	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E6C67_RS28680	COG3385	transposase activity
E6C67_RS28700	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E6C67_RS28720	COG2270	Major facilitator Superfamily
E6C67_RS28725	COG2264	protein methyltransferase activity
E6C67_RS28730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E6C67_RS28765	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E6C67_RS28855	COG0406	alpha-ribazole phosphatase activity
E6C67_RS28875	COG0745	RESPONSE REGULATOR receiver
E6C67_RS28955	COG1509	lysine 2,3-aminomutase activity
E6C67_RS28960	COG0584	glycerophosphoryl diester phosphodiesterase
E6C67_RS28985	COG2202	Pas domain
E6C67_RS28985	COG2205	protein histidine kinase activity
E6C67_RS29000	COG3162	membrane
E6C67_RS29015	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS29030	COG1960	acyl-CoA dehydrogenase activity
E6C67_RS29035	COG1187	pseudouridine synthase activity
E6C67_RS29045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E6C67_RS29055	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E6C67_RS29060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E6C67_RS29065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E6C67_RS29090	COG0784	Response regulator, receiver
E6C67_RS29090	COG3437	response regulator, receiver
E6C67_RS29100	COG0583	DNA-binding transcription factor activity
E6C67_RS29110	COG0252	asparaginase activity
E6C67_RS29130	COG0297	glycogen (starch) synthase activity
E6C67_RS29140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E6C67_RS29145	COG0004	ammonium transporteR
E6C67_RS29150	COG1741	Belongs to the pirin family
E6C67_RS29160	COG0753	catalase activity
E6C67_RS29175	COG2313	pseudouridylate synthase activity
E6C67_RS29185	COG1793	dna ligase
E6C67_RS29205	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS29215	COG0840	transmembrane signaling receptor activity
E6C67_RS29235	COG0135	phosphoribosylanthranilate isomerase activity
E6C67_RS29250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E6C67_RS29260	COG0156	8-amino-7-oxononanoate synthase activity
E6C67_RS29280	COG1177	transmembrane transport
E6C67_RS29300	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E6C67_RS29310	COG3278	Belongs to the heme-copper respiratory oxidase family
E6C67_RS29345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C67_RS29350	COG1612	heme a metabolic process
E6C67_RS29355	COG3772	lysozyme
E6C67_RS29360	COG5425	PFAM Usg family protein
E6C67_RS29365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E6C67_RS29370	COG0459	protein refolding
E6C67_RS29385	COG4566	intracellular signal transduction
E6C67_RS29400	COG0604	alcohol dehydrogenase
E6C67_RS29405	COG0583	DNA-binding transcription factor activity
E6C67_RS29425	COG4608	Belongs to the ABC transporter superfamily
E6C67_RS29430	COG0444	Belongs to the ABC transporter superfamily
E6C67_RS29435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C67_RS29440	COG0601	transmembrane transport
E6C67_RS29450	COG0492	ferredoxin-NADP+ reductase activity
E6C67_RS29460	COG1695	Transcriptional regulator
E6C67_RS29475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E6C67_RS29485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E6C67_RS29500	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E6C67_RS29505	COG1595	DNA-templated transcription, initiation
E6C67_RS29530	COG2202	Pas domain
E6C67_RS29530	COG2205	protein histidine kinase activity
E6C67_RS29555	COG2358	TRAP transporter, solute receptor (TAXI family
E6C67_RS29575	COG0825	malonyl-CoA metabolic process
E6C67_RS29585	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E6C67_RS29590	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E6C67_RS29595	COG1842	Phage shock protein A
E6C67_RS29615	COG1216	Glycosyl transferase, family 2
E6C67_RS29615	COG1442	glycosyl transferase family 8
E6C67_RS29645	COG0181	hydroxymethylbilane synthase activity
E6C67_RS29655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E6C67_RS29680	COG0587	DNA-directed DNA polymerase activity
E6C67_RS29700	COG3437	response regulator, receiver
E6C67_RS29700	COG0784	Response regulator, receiver
E6C67_RS29705	COG3158	transport of potassium into the cell
E6C67_RS29725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E6C67_RS29730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E6C67_RS29735	COG0842	Transport permease protein
E6C67_RS29740	COG2137	regulation of response to DNA damage stimulus
E6C67_RS29745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E6C67_RS29755	COG1703	isobutyryl-CoA mutase activity
E6C67_RS29760	COG4172	Belongs to the ABC transporter superfamily
E6C67_RS29770	COG4239	(ABC) transporter, permease
E6C67_RS29775	COG4174	ABC transporter (Permease)
E6C67_RS29780	COG4166	transmembrane transport
E6C67_RS29785	COG4166	transmembrane transport
E6C67_RS29810	COG0077	Prephenate dehydratase
E6C67_RS29820	COG3474	cytochrome
E6C67_RS29835	COG2766	serine protein kinase
E6C67_RS29840	COG2718	Belongs to the UPF0229 family
E6C67_RS29850	COG2719	SpoVR family
E6C67_RS29870	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS29875	COG1254	Belongs to the acylphosphatase family
E6C67_RS29900	COG0671	phosphoesterase, PA-phosphatase related
E6C67_RS29910	COG2239	Acts as a magnesium transporter
E6C67_RS29915	COG2022	thiamine diphosphate biosynthetic process
E6C67_RS29915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_RS29925	COG2022	thiamine diphosphate biosynthetic process
E6C67_RS30010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E6C67_RS30015	COG3108	Peptidase M15
E6C67_RS30025	COG3038	cytochrome b561
E6C67_RS30035	COG0642	Histidine kinase
E6C67_RS30040	COG0745	RESPONSE REGULATOR receiver
E6C67_RS30050	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E6C67_RS30055	COG0277	FAD linked oxidase domain protein
E6C67_RS30060	COG0277	FAD linked oxidase domain protein
E6C67_RS30065	COG0247	lactate metabolic process
E6C67_RS30090	COG1454	alcohol dehydrogenase
E6C67_RS30105	COG1960	acyl-CoA dehydrogenase activity
E6C67_RS30125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E6C67_RS30130	COG2171	N-acyltransferase activity
E6C67_RS30165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E6C67_RS30170	COG0228	four-way junction DNA binding
E6C67_RS30175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E6C67_RS30180	COG0336	Belongs to the RNA methyltransferase TrmD family
E6C67_RS30185	COG0335	large ribosomal subunit rRNA binding
E6C67_RS30190	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E6C67_RS30200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E6C67_RS30205	COG0706	membrane insertase activity
E6C67_RS30210	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E6C67_RS30220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E6C67_RS30235	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E6C67_RS30245	COG1530	ribonuclease E activity
E6C67_RS30250	COG0860	N-Acetylmuramoyl-L-alanine amidase
E6C67_RS30285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E6C67_RS30285	COG0561	phosphatase activity
E6C67_RS30320	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E6C67_RS30325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_RS30330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_RS30415	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E6C67_RS30435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E6C67_RS30440	COG0081	regulation of translation
E6C67_RS30445	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E6C67_RS30450	COG0222	ribosome binding
E6C67_RS30455	COG0085	RNA polymerase activity
E6C67_RS30460	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E6C67_RS30470	COG0049	tRNA binding
E6C67_RS30480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E6C67_RS30485	COG0051	transcription antitermination factor activity, RNA binding
E6C67_RS30495	COG0088	Forms part of the polypeptide exit tunnel
E6C67_RS30500	COG0089	rRNA binding
E6C67_RS30505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E6C67_RS30510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E6C67_RS30515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E6C67_RS30520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E6C67_RS30525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E6C67_RS30530	COG0255	Belongs to the universal ribosomal protein uL29 family
E6C67_RS30535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E6C67_RS30545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E6C67_RS30555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E6C67_RS30560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E6C67_RS30565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E6C67_RS30575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E6C67_RS30580	COG1841	ribosomal large subunit assembly
E6C67_RS30585	COG0200	Binds to the 23S rRNA
E6C67_RS30595	COG0563	adenylate kinase activity
E6C67_RS30605	COG0697	spore germination
E6C67_RS30620	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E6C67_RS30625	COG2873	o-acetylhomoserine
E6C67_RS30630	COG2267	carboxylic ester hydrolase activity
E6C67_RS30640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E6C67_RS30670	COG1285	pathogenesis
E6C67_RS30675	COG2814	Major facilitator Superfamily
E6C67_RS30680	COG0196	riboflavin kinase activity
E6C67_RS30685	COG2030	dehydratase
E6C67_RS30690	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E6C67_RS30705	COG0628	permease
E6C67_RS30735	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E6C67_RS30740	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E6C67_RS30750	COG1597	lipid kinase activity
E6C67_RS30760	COG0438	transferase activity, transferring glycosyl groups
E6C67_RS30765	COG1280	lysine exporter protein (LysE YggA)
E6C67_RS30770	COG1519	Transferase
E6C67_RS30775	COG1663	tetraacyldisaccharide 4'-kinase activity
E6C67_RS30795	COG2205	protein histidine kinase activity
E6C67_RS30795	COG0784	Response regulator, receiver
E6C67_RS30795	COG5002	protein histidine kinase activity
E6C67_RS30805	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E6C67_RS30810	COG0644	oxidoreductase
E6C67_RS30865	COG1902	pentaerythritol trinitrate reductase activity
E6C67_RS30875	COG2962	Rard protein
E6C67_RS30890	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E6C67_RS30900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E6C67_RS30915	COG2205	protein histidine kinase activity
E6C67_RS30930	COG0395	ABC-type sugar transport system, permease component
E6C67_RS30940	COG5508	conserved small protein
E6C67_RS30950	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E6C67_RS30980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E6C67_RS30990	COG4584	PFAM Integrase catalytic
E6C67_RS30995	COG1484	DNA-dependent DNA replication
E6C67_RS31000	COG2390	Transcriptional regulator
E6C67_RS31000	COG4584	PFAM Integrase catalytic
E6C67_RS31005	COG1484	DNA-dependent DNA replication
E6C67_RS31010	COG2433	Pfam Transposase IS66
E6C67_RS31015	COG3436	PFAM IS66 Orf2 family protein
E6C67_RS31090	COG3852	Histidine kinase
E6C67_RS31095	COG1366	Belongs to the anti-sigma-factor antagonist family
E6C67_RS31120	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E6C67_RS31145	COG1686	Belongs to the peptidase S11 family
E6C67_RS31160	COG2205	protein histidine kinase activity
E6C67_RS31160	COG2202	Pas domain
E6C67_RS31165	COG5002	protein histidine kinase activity
E6C67_RS31170	COG2205	protein histidine kinase activity
E6C67_RS31180	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E6C67_RS31200	COG0166	Belongs to the GPI family
E6C67_RS31210	COG0612	Peptidase, M16
E6C67_RS31250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E6C67_RS31255	COG2703	oxygen carrier activity
E6C67_RS31270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E6C67_RS31285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_RS31295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E6C67_RS31315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E6C67_RS31320	COG0746	molybdenum cofactor guanylyltransferase activity
E6C67_RS31345	COG0243	molybdopterin cofactor binding
E6C67_RS31345	COG3383	formate dehydrogenase (NAD+) activity
E6C67_RS31350	COG0437	4 iron, 4 sulfur cluster binding
E6C67_RS31365	COG0235	Class ii aldolase
E6C67_RS31370	COG5002	protein histidine kinase activity
E6C67_RS31370	COG0784	Response regulator, receiver
E6C67_RS31375	COG3384	dioxygenase
E6C67_RS31385	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E6C67_RS31390	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E6C67_RS31395	COG0356	it plays a direct role in the translocation of protons across the membrane
E6C67_RS31405	COG1999	signal sequence binding
E6C67_RS31415	COG1702	phosphate starvation-inducible protein PhoH
E6C67_RS31420	COG0850	regulation of cytokinetic process
E6C67_RS31425	COG2894	cell division
E6C67_RS31430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E6C67_RS31455	COG4948	Mandelate Racemase Muconate Lactonizing
E6C67_RS31460	COG2154	pterin-4-alpha-carbinolamine dehydratase
E6C67_RS31465	COG1573	uracil-dna glycosylase
E6C67_RS31470	COG2264	protein methyltransferase activity
E6C67_RS31495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E6C67_RS31505	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
E6C67_RS31510	COG5420	small protein containing a coiled-coil domain
E6C67_RS31525	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
E6C67_RS31530	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
E6C67_RS31575	COG0121	glutamine amidotransferase
E6C67_RS31585	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E6C67_RS31590	COG0552	protein localization to endoplasmic reticulum
E6C67_RS31595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E6C67_RS31600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E6C67_RS31635	COG2301	Belongs to the HpcH HpaI aldolase family
E6C67_RS31640	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E6C67_RS31645	COG2205	protein histidine kinase activity
E6C67_RS31650	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E6C67_RS31655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E6C67_RS31670	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E6C67_RS31675	COG1063	alcohol dehydrogenase
E6C67_RS31685	COG0596	Alpha beta hydrolase
E6C67_RS31685	COG0508	dehydrogenase complex catalyzes the overall conversion of
E6C67_RS31690	COG0022	dehydrogenase e1 component
E6C67_RS31695	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E6C67_RS31700	COG3199	ATP-NAD kinase
E6C67_RS31705	COG0277	FAD linked oxidase domain protein
E6C67_RS31710	COG1671	Belongs to the UPF0178 family
E6C67_RS31715	COG0488	(ABC) transporter
E6C67_RS31740	COG2853	Lipoprotein
E6C67_RS31765	COG0646	methionine synthase
E6C67_RS31765	COG1410	methionine synthase
E6C67_RS31795	COG3706	GGDEF domain
E6C67_RS31800	COG2070	2-Nitropropane dioxygenase
E6C67_RS31815	COG0488	(ABC) transporter
E6C67_RS31820	COG2814	Major facilitator Superfamily
E6C67_RS31835	COG0175	sulfate reduction
E6C67_RS31840	COG1648	precorrin-2 dehydrogenase activity
E6C67_RS31840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E6C67_RS31850	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E6C67_RS31865	COG3108	Peptidase M15
E6C67_RS31875	COG2202	Pas domain
E6C67_RS31875	COG2205	protein histidine kinase activity
E6C67_RS31880	COG4566	intracellular signal transduction
E6C67_RS31905	COG0243	molybdopterin cofactor binding
E6C67_RS31915	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E6C67_RS31915	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E6C67_RS31930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E6C67_RS31940	COG0612	Peptidase, M16
E6C67_RS31945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E6C67_RS31970	COG0483	inositol monophosphate 1-phosphatase activity
E6C67_RS31975	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E6C67_RS31990	COG0730	response to heat
E6C67_RS31995	COG0352	thiamine-phosphate diphosphorylase activity
E6C67_RS32000	COG1830	Aldolase
E6C67_RS32050	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E6C67_RS32055	COG1692	metallophosphoesterase
E6C67_RS32060	COG0217	transcriptional regulatory protein
E6C67_RS32070	COG0632	four-way junction helicase activity
E6C67_RS32075	COG2255	four-way junction helicase activity
E6C67_RS32080	COG0824	Thioesterase
E6C67_RS32090	COG0848	biopolymer transport protein
E6C67_RS32105	COG2885	chlorophyll binding
E6C67_RS32120	COG0037	tRNA processing
E6C67_RS32125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E6C67_RS32145	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E6C67_RS32150	COG1295	ribonuclease BN
E6C67_RS32155	COG3385	transposase activity
E6C67_RS32165	COG4520	surface antigen
E6C67_RS32170	COG0259	pyridoxamine-phosphate oxidase activity
E6C67_RS32180	COG0840	transmembrane signaling receptor activity
E6C67_RS32200	COG2153	protein acetylation
E6C67_RS32215	COG3685	Protein conserved in bacteria
E6C67_RS32230	COG4957	zinc ion binding
E6C67_RS32235	COG0698	ribose 5-phosphate isomerase
E6C67_RS32240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E6C67_RS32245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E6C67_RS32250	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E6C67_RS32265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E6C67_RS32275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E6C67_RS32275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E6C67_RS32285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E6C67_RS32285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E6C67_RS32305	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E6C67_RS32310	COG0416	fatty acid biosynthetic process
E6C67_RS32315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E6C67_RS32365	COG0811	peptide transport
E6C67_RS32370	COG0848	biopolymer transport protein
E6C67_RS32385	COG4774	siderophore transport
E6C67_RS32390	COG1764	response to oxidative stress
E6C67_RS32395	COG1846	Transcriptional regulator
E6C67_RS32400	COG0456	acetyltransferase
E6C67_RS32410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E6C67_RS32415	COG1393	Belongs to the ArsC family
E6C67_RS32420	COG2890	protein-(glutamine-N5) methyltransferase activity
E6C67_RS32430	COG1403	HNH endonuclease
E6C67_RS32460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E6C67_RS32480	COG1136	(ABC) transporter
E6C67_RS32480	COG4591	ABC-type transport system involved in lipoprotein release permease component
E6C67_RS32520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E6C67_RS32545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E6C67_RS32555	COG3108	Peptidase M15
E6C67_RS32580	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E6C67_RS32585	COG0511	ligase activity, forming carbon-carbon bonds
E6C67_RS32590	COG0439	Biotin carboxylase
E6C67_RS32595	COG0840	transmembrane signaling receptor activity
E6C67_RS32600	COG4251	negative regulation of phosphorylation
E6C67_RS32605	COG4251	negative regulation of phosphorylation
E6C67_RS32610	COG0784	Response regulator, receiver
E6C67_RS32625	COG0745	RESPONSE REGULATOR receiver
E6C67_RS32645	COG0432	Pfam Uncharacterised protein family UPF0047
E6C67_RS32660	COG2205	protein histidine kinase activity
E6C67_RS32665	COG0628	permease
E6C67_RS32675	COG3385	transposase activity
E6C67_RS32680	COG0616	signal peptide processing
E6C67_RS32690	COG0745	RESPONSE REGULATOR receiver
E6C67_RS32705	COG0840	transmembrane signaling receptor activity
E6C67_RS32710	COG0436	Aminotransferase
E6C67_RS32720	COG1494	fructose-1,6-bisphosphatase
E6C67_RS32740	COG1324	tolerance protein
E6C67_RS32745	COG0303	'Molybdopterin
E6C67_RS32750	COG0583	DNA-binding transcription factor activity
E6C67_RS32755	COG2373	Large extracellular alpha-helical protein
E6C67_RS32760	COG4953	penicillin-binding protein 1C
E6C67_RS32775	COG2132	Multicopper oxidase
E6C67_RS32785	COG4636	protein conserved in cyanobacteria
E6C67_RS32790	COG0494	nUDIX hydrolase
E6C67_RS32795	COG0024	Methionine aminopeptidase
E6C67_RS32815	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E6C67_RS32820	COG4221	oxidoreductase activity
E6C67_RS32825	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E6C67_RS32850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E6C67_RS32885	COG0473	3-isopropylmalate dehydrogenase activity
E6C67_RS32910	COG0330	HflC and HflK could
E6C67_RS32920	COG0538	isocitrate dehydrogenase activity
E6C67_RS32925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E6C67_RS32930	COG0359	binds to the 23S rRNA
E6C67_RS32940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E6C67_RS32945	COG0360	Binds together with S18 to 16S ribosomal RNA
E6C67_RS32955	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E6C67_RS32970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E6C67_RS32975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E6C67_RS32990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E6C67_RS33035	COG0784	Response regulator, receiver
E6C67_RS33035	COG3437	response regulator, receiver
E6C67_RS33050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_RS33050	COG4191	Histidine kinase
E6C67_RS33080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_RS33085	COG2358	TRAP transporter, solute receptor (TAXI family
E6C67_RS33090	COG1607	acyl-coa hydrolase
E6C67_RS33095	COG0187	DNA topoisomerase II activity
E6C67_RS33130	COG0513	Belongs to the DEAD box helicase family
E6C67_RS33165	COG1561	YicC-like family, N-terminal region
E6C67_RS33180	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E6C67_RS33185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E6C67_RS33190	COG0052	Belongs to the universal ribosomal protein uS2 family
E6C67_RS33195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E6C67_RS33200	COG0528	UMP kinase activity
E6C67_RS33205	COG0233	cytoplasmic translational termination
E6C67_RS33210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E6C67_RS33220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E6C67_RS33225	COG0750	zinc metalloprotease
E6C67_RS33250	COG3494	Protein of unknown function (DUF1009)
E6C67_RS33255	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E6C67_RS33265	COG4977	sequence-specific DNA binding
E6C67_RS33270	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E6C67_RS33280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E6C67_RS33285	COG0658	competence protein
E6C67_RS33285	COG2333	competence protein COMEC
E6C67_RS33290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E6C67_RS33295	COG0303	'Molybdopterin
E6C67_RS33300	COG0315	cyclic pyranopterin monophosphate synthase activity
E6C67_RS33365	COG1492	cobalamin metabolic process
E6C67_RS33380	COG2897	thiosulfate sulfurtransferase activity
E6C67_RS33395	COG0494	nUDIX hydrolase
E6C67_RS33400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C67_RS33430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E6C67_RS33440	COG1538	Outer membrane efflux protein
E6C67_RS33450	COG0525	valine-tRNA ligase activity
E6C67_RS33455	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E6C67_RS33460	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E6C67_RS33470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E6C67_RS33475	COG0628	permease
E6C67_RS33485	COG0300	oxidoreductase activity
E6C67_RS33490	COG1846	Transcriptional regulator
E6C67_RS33495	COG0124	histidyl-tRNA synthetase
E6C67_RS33530	COG1396	sequence-specific DNA binding
E6C67_RS33615	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E6C67_RS33620	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E6C67_RS33655	COG1366	Belongs to the anti-sigma-factor antagonist family
E6C67_RS33660	COG2208	phosphoserine phosphatase activity
E6C67_RS33670	COG5002	protein histidine kinase activity
E6C67_RS33670	COG2205	protein histidine kinase activity
E6C67_RS33670	COG0784	Response regulator, receiver
E6C67_RS33675	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E6C67_RS33700	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS33705	COG0443	Heat shock 70 kDa protein
E6C67_RS33710	COG0489	protein tyrosine kinase activity
E6C67_RS33715	COG0330	HflC and HflK could
E6C67_RS33720	COG0330	HflC and HflK could
E6C67_RS33725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C67_RS33730	COG2197	response regulator
E6C67_RS33740	COG0745	RESPONSE REGULATOR receiver
E6C67_RS33750	COG1846	Transcriptional regulator
E6C67_RS33760	COG0149	triose-phosphate isomerase activity
E6C67_RS33785	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E6C67_RS33795	COG1566	PFAM secretion protein HlyD family protein
E6C67_RS33800	COG1136	(ABC) transporter
E6C67_RS33805	COG1136	(ABC) transporter
E6C67_RS33805	COG0577	efflux transmembrane transporter activity
E6C67_RS33835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E6C67_RS33840	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E6C67_RS33845	COG0534	Mate efflux family protein
E6C67_RS33865	COG0741	lytic transglycosylase activity
E6C67_RS33870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E6C67_RS33875	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E6C67_RS33880	COG2813	Specifically methylates the guanine in position
E6C67_RS33885	COG0667	Aldo Keto reductase
E6C67_RS33900	COG1881	PFAM PEBP family protein
E6C67_RS33905	COG0113	porphobilinogen synthase activity
E6C67_RS33915	COG1597	lipid kinase activity
E6C67_RS33920	COG1024	Enoyl-CoA hydratase
E6C67_RS33925	COG1846	Transcriptional regulator
E6C67_RS33940	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS33955	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E6C67_RS33965	COG2264	protein methyltransferase activity
E6C67_RS33980	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS33990	COG0456	acetyltransferase
E6C67_RS33995	COG0058	SHG alpha-glucan phosphorylase activity
E6C67_RS34000	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E6C67_RS34005	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E6C67_RS34020	COG1305	Transglutaminase-like
E6C67_RS34025	COG2307	Protein conserved in bacteria
E6C67_RS34025	COG2308	Evidence 4 Homologs of previously reported genes of
E6C67_RS34030	COG2010	Cytochrome c
E6C67_RS34050	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS34060	COG0583	DNA-binding transcription factor activity
E6C67_RS34090	COG3784	Protein of unknown function (DUF1318)
E6C67_RS34120	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
E6C67_RS34125	COG2814	Major facilitator Superfamily
E6C67_RS34130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E6C67_RS34140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E6C67_RS34155	COG1862	Preprotein translocase
E6C67_RS34160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E6C67_RS34170	COG3737	Protein of unknown function (DUF498/DUF598)
E6C67_RS34175	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E6C67_RS34180	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
E6C67_RS34185	COG1562	ergosterol biosynthetic process
E6C67_RS34190	COG1562	ergosterol biosynthetic process
E6C67_RS34220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E6C67_RS34235	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E6C67_RS34240	COG0248	Ppx GppA phosphatase
E6C67_RS34255	COG0617	tRNA 3'-terminal CCA addition
E6C67_RS34270	COG0714	Associated with various cellular activities
E6C67_RS34310	COG4584	PFAM Integrase catalytic
E6C67_RS34310	COG2390	Transcriptional regulator
E6C67_RS34315	COG1484	DNA-dependent DNA replication
E6C67_RS34320	COG1484	DNA-dependent DNA replication
E6C67_RS34325	COG4584	PFAM Integrase catalytic
E6C67_RS34365	COG2226	methyltransferase
E6C67_RS34370	COG2814	Major facilitator Superfamily
E6C67_RS34375	COG0583	DNA-binding transcription factor activity
E6C67_RS34380	COG0629	single-stranded DNA binding
E6C67_RS34410	COG0123	including yeast histone deacetylase and acetoin utilization protein
E6C67_RS34415	COG1116	anion transmembrane transporter activity
E6C67_RS34420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_RS34425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E6C67_RS34435	COG0483	inositol monophosphate 1-phosphatase activity
E6C67_RS34450	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E6C67_RS34455	COG1923	regulation of RNA biosynthetic process
E6C67_RS34465	COG2204	response regulator
E6C67_RS34495	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E6C67_RS34495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E6C67_RS34505	COG1942	4-Oxalocrotonate Tautomerase
E6C67_RS34510	COG2867	negative regulation of translational initiation
E6C67_RS34515	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E6C67_RS34525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E6C67_RS34535	COG0508	dehydrogenase complex catalyzes the overall conversion of
E6C67_RS34540	COG0508	dehydrogenase complex catalyzes the overall conversion of
E6C67_RS34540	COG0022	dehydrogenase e1 component
E6C67_RS34545	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E6C67_RS34565	COG4149	molybdate abc transporter
E6C67_RS34570	COG0725	ABC transporter, periplasmic molybdate-binding protein
E6C67_RS34575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E6C67_RS34585	COG2261	transglycosylase associated protein
E6C67_RS34600	COG2135	peptidase activity
E6C67_RS34610	COG2200	EAL domain
E6C67_RS34610	COG3287	FIST C domain
E6C67_RS34610	COG2199	diguanylate cyclase activity
E6C67_RS34620	COG1218	3'(2'),5'-bisphosphate nucleotidase
E6C67_RS34625	COG2833	Protein of unknown function (DUF455)
E6C67_RS34630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E6C67_RS34635	COG0328	RNA-DNA hybrid ribonuclease activity
E6C67_RS34640	COG0678	peroxiredoxin activity
E6C67_RS34645	COG2824	Alkylphosphonate utilization operon protein PhnA
E6C67_RS34650	COG4232	protein-disulfide reductase activity
E6C67_RS34655	COG1678	Uncharacterized ACR, COG1678
E6C67_RS34660	COG0314	molybdopterin synthase activity
E6C67_RS34665	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E6C67_RS34675	COG0546	phosphoglycolate phosphatase activity
E6C67_RS34680	COG1763	Mo-molybdopterin cofactor biosynthetic process
E6C67_RS34685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E6C67_RS34695	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_RS34720	COG4120	Belongs to the binding-protein-dependent transport system permease family
E6C67_RS34735	COG0672	)-iron permease
E6C67_RS34750	COG0640	Transcriptional regulator
E6C67_RS34770	COG0583	DNA-binding transcription factor activity
E6C67_RS34775	COG0540	Belongs to the ATCase OTCase family
E6C67_RS34780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E6C67_RS34790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C67_RS34810	COG0776	regulation of translation
E6C67_RS34815	COG4957	zinc ion binding
E6C67_RS34850	COG0741	lytic transglycosylase activity
E6C67_RS34855	COG0556	nucleotide-excision repair
E6C67_RS34880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E6C67_RS34885	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E6C67_RS34905	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E6C67_RS34915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E6C67_RS34920	COG1126	abc transporter atp-binding protein
E6C67_RS34925	COG0765	amino acid transport
E6C67_RS34930	COG4597	amino acid ABC transporter
E6C67_RS34935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_RS34940	COG0626	cystathionine gamma-synthase activity
E6C67_RS34960	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_RS34960	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E6C67_RS34995	COG2308	Evidence 4 Homologs of previously reported genes of
E6C67_RS35000	COG1360	Flagellar Motor Protein
E6C67_RS35005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E6C67_RS35025	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_RS35030	COG0789	Transcriptional regulator
E6C67_RS35040	COG2086	electron transfer activity
E6C67_RS35060	COG2205	protein histidine kinase activity
E6C67_RS35065	COG0728	peptidoglycan biosynthetic process
E6C67_RS35070	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E6C67_RS35090	COG1765	OsmC-like protein
E6C67_RS35095	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E6C67_RS35105	COG5487	UPF0391 membrane protein
E6C67_RS35115	COG0739	heme binding
E6C67_RS35115	COG0741	lytic transglycosylase activity
E6C67_RS35115	COG1196	nuclear chromosome segregation
E6C67_RS35130	COG2226	methyltransferase
E6C67_RS35145	COG1217	gtp-binding protein TYPA
E6C67_RS35150	COG1178	ABC-type Fe3 transport system permease component
E6C67_RS35170	COG1752	Esterase of the alpha-beta hydrolase superfamily
E6C67_RS35175	COG1132	(ABC) transporter
E6C67_RS35180	COG3842	ATPase activity
E6C67_RS35185	COG1840	ABC-type Fe3 transport system, periplasmic component
E6C67_RS35190	COG5001	Diguanylate cyclase
E6C67_RS35200	COG1742	UPF0060 membrane protein
E6C67_RS35210	COG3237	CsbD-like
E6C67_RS35215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E6C67_RS35220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E6C67_RS35230	COG3346	SURF1 family
E6C67_RS35240	COG1845	cytochrome c oxidase, subunit III
E6C67_RS35245	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E6C67_RS35255	COG0109	protoheme IX farnesyltransferase activity
E6C67_RS35260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E6C67_RS35265	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E6C67_RS35275	COG0312	modulator of DNA gyrase
E6C67_RS35295	COG2076	Multidrug Resistance protein
E6C67_RS35305	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E6C67_RS35345	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E6C67_RS35355	COG1987	bacterial-type flagellum assembly
E6C67_RS35360	COG1677	Flagellar hook-basal body complex protein FliE
E6C67_RS35365	COG1558	bacterial-type flagellum-dependent cell motility
E6C67_RS35370	COG1815	bacterial-type flagellum-dependent cell motility
E6C67_RS35375	COG2257	FlhB HrpN YscU SpaS Family
E6C67_RS35390	COG1338	Plays a role in the flagellum-specific transport system
E6C67_RS35400	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E6C67_RS35410	COG1360	Flagellar Motor Protein
E6C67_RS35425	COG1752	Esterase of the alpha-beta hydrolase superfamily
E6C67_RS35435	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E6C67_RS35450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E6C67_RS35460	COG0571	ribonuclease III activity
E6C67_RS35465	COG0681	Belongs to the peptidase S26 family
E6C67_RS35470	COG0736	holo-[acyl-carrier-protein] synthase activity
E6C67_RS35475	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E6C67_RS35485	COG1758	RNA polymerase activity
E6C67_RS35500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E6C67_RS35550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E6C67_RS35580	COG0640	Transcriptional regulator
E6C67_RS35590	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_RS35635	COG4372	Transposase
E6C67_RS35640	COG3436	PFAM IS66 Orf2 family protein
E6C67_RS35665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C67_RS35680	COG0583	DNA-binding transcription factor activity
E6C67_RS35710	COG3436	PFAM IS66 Orf2 family protein
E6C67_RS35735	COG1475	DNA binding
E6C67_RS35755	COG1396	sequence-specific DNA binding
E6C67_RS35800	COG1475	DNA binding
E6C67_RS35915	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_RS35985	COG0681	Belongs to the peptidase S26 family
E6C67_RS36100	COG0501	Belongs to the peptidase M48B family
E6C67_RS36190	COG0583	DNA-binding transcription factor activity
E6C67_RS36195	COG1063	alcohol dehydrogenase
E6C67_RS36310	COG3437	response regulator, receiver
E6C67_RS36310	COG2770	Histidine kinase
E6C67_RS36325	COG1484	DNA-dependent DNA replication
E6C67_RS36330	COG4584	PFAM Integrase catalytic
E6C67_RS36500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E6C67_RS36505	COG4957	zinc ion binding
E6C67_RS36535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E6C67_RS36620	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E6C67_RS36625	COG1116	anion transmembrane transporter activity
E6C67_RS36630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_RS36660	COG1937	Protein conserved in bacteria
E6C67_RS36665	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_RS36675	COG5002	protein histidine kinase activity
E6C67_RS36680	COG0586	Pfam SNARE associated Golgi protein
E6C67_RS36685	COG0671	phosphoesterase, PA-phosphatase related
E6C67_RS36690	COG0586	Pfam SNARE associated Golgi protein
E6C67_RS36740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E6C67_RS36750	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E6C67_RS36750	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_RS36760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_RS36775	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E6C67_RS36780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E6C67_RS36785	COG0583	DNA-binding transcription factor activity
E6C67_RS36810	COG0745	RESPONSE REGULATOR receiver
E6C67_RS36810	COG4566	intracellular signal transduction
E6C67_RS36815	COG2203	Gaf domain
E6C67_RS36815	COG2199	diguanylate cyclase activity
E6C67_RS36855	COG3901	Regulator of nitric oxide reductase transcription
E6C67_RS36855	COG0348	domain, Protein
E6C67_RS36880	COG0671	phosphoesterase, PA-phosphatase related
E6C67_RS36900	COG3436	PFAM IS66 Orf2 family protein
E6C67_RS36905	COG2433	Pfam Transposase IS66
E6C67_RS36910	COG4372	Transposase
E6C67_RS36940	COG2204	response regulator
E6C67_RS37065	COG0586	Pfam SNARE associated Golgi protein
E6C67_RS37070	COG0671	phosphoesterase, PA-phosphatase related
E6C67_RS37075	COG0586	Pfam SNARE associated Golgi protein
E6C67_RS37080	COG5002	protein histidine kinase activity
E6C67_RS37095	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E6C67_RS37120	COG1937	Protein conserved in bacteria
E6C67_RS37135	COG0586	Pfam SNARE associated Golgi protein
E6C67_RS37140	COG0671	phosphoesterase, PA-phosphatase related
E6C67_RS37205	COG3258	Cytochrome c
E6C67_RS37230	COG2132	Multicopper oxidase