locus-tag	class	description
E6C72_RS00035	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E6C72_RS00050	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E6C72_RS00060	COG2910	NAD(P)H-binding
E6C72_RS00085	COG0742	ribosomal rna small subunit methyltransferase
E6C72_RS00090	COG1187	pseudouridine synthase activity
E6C72_RS00095	COG0590	tRNA wobble adenosine to inosine editing
E6C72_RS00115	COG1570	exodeoxyribonuclease VII activity
E6C72_RS00130	COG0418	dihydroorotase activity
E6C72_RS00150	COG1404	Belongs to the peptidase S8 family
E6C72_RS00160	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E6C72_RS00165	COG0193	aminoacyl-tRNA hydrolase activity
E6C72_RS00170	COG0012	GTP binding
E6C72_RS00175	COG1283	sodium-dependent phosphate transmembrane transporter activity
E6C72_RS00180	COG5001	Diguanylate cyclase
E6C72_RS00180	COG3300	MHYT domain
E6C72_RS00190	COG1454	alcohol dehydrogenase
E6C72_RS00210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E6C72_RS00225	COG2945	thiolester hydrolase activity
E6C72_RS00230	COG1045	serine acetyltransferase
E6C72_RS00240	COG1104	cysteine desulfurase activity
E6C72_RS00245	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E6C72_RS00255	COG0482	sulfurtransferase activity
E6C72_RS00270	COG3284	Transcriptional regulator
E6C72_RS00295	COG0488	(ABC) transporter
E6C72_RS00315	COG2001	Belongs to the MraZ family
E6C72_RS00335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E6C72_RS00345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E6C72_RS00350	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E6C72_RS00360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E6C72_RS00370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E6C72_RS00375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E6C72_RS00380	COG1181	Belongs to the D-alanine--D-alanine ligase family
E6C72_RS00385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E6C72_RS00390	COG0849	cell division
E6C72_RS00395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E6C72_RS00410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E6C72_RS00430	COG0248	Ppx GppA phosphatase
E6C72_RS00440	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E6C72_RS00445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E6C72_RS00460	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E6C72_RS00520	COG4603	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS00525	COG3845	ABC transporter
E6C72_RS00530	COG0354	folic acid binding
E6C72_RS00545	COG0546	phosphoglycolate phosphatase activity
E6C72_RS00550	COG0564	pseudouridine synthase activity
E6C72_RS00555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E6C72_RS00560	COG1335	isochorismatase
E6C72_RS00570	COG1136	(ABC) transporter
E6C72_RS00580	COG0442	prolyl-tRNA aminoacylation
E6C72_RS00595	COG0519	Catalyzes the synthesis of GMP from XMP
E6C72_RS00605	COG0346	lactoylglutathione lyase activity
E6C72_RS00625	COG1007	ATP synthesis coupled electron transport
E6C72_RS00640	COG0713	ATP synthesis coupled electron transport
E6C72_RS00655	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E6C72_RS00660	COG1034	ATP synthesis coupled electron transport
E6C72_RS00670	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E6C72_RS00675	COG0649	NAD binding
E6C72_RS00680	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E6C72_RS00685	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E6C72_RS00690	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E6C72_RS00770	COG0500	methyltransferase
E6C72_RS00775	COG0140	phosphoribosyl-ATP diphosphatase activity
E6C72_RS00785	COG2862	Uncharacterized protein family, UPF0114
E6C72_RS00805	COG0768	penicillin binding
E6C72_RS00810	COG1215	transferase activity, transferring glycosyl groups
E6C72_RS00820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E6C72_RS00830	COG0028	Belongs to the TPP enzyme family
E6C72_RS00835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C72_RS00840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E6C72_RS00845	COG3830	Belongs to the UPF0237 family
E6C72_RS00845	COG0560	Phosphoserine phosphatase
E6C72_RS00855	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E6C72_RS00870	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E6C72_RS00875	COG0830	nickel cation binding
E6C72_RS00880	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
E6C72_RS00885	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E6C72_RS00890	COG0804	urea catabolic process
E6C72_RS00895	COG0832	Belongs to the urease beta subunit family
E6C72_RS00900	COG0831	urea catabolic process
E6C72_RS00905	COG0829	nickel cation binding
E6C72_RS00910	COG2197	response regulator
E6C72_RS00915	COG2197	response regulator
E6C72_RS00920	COG0693	protein deglycase activity
E6C72_RS00935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E6C72_RS00940	COG0717	Belongs to the dCTP deaminase family
E6C72_RS00960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E6C72_RS00995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E6C72_RS01005	COG0557	exoribonuclease II activity
E6C72_RS01010	COG0793	Belongs to the peptidase S41A family
E6C72_RS01015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E6C72_RS01020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E6C72_RS01035	COG1380	Effector of murein hydrolase LrgA
E6C72_RS01040	COG1346	cytolysis
E6C72_RS01065	COG1496	oxidoreductase activity
E6C72_RS01070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E6C72_RS01100	COG0784	Response regulator, receiver
E6C72_RS01100	COG4191	Histidine kinase
E6C72_RS01120	COG1131	(ABC) transporter
E6C72_RS01130	COG1309	transcriptional regulator
E6C72_RS01150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E6C72_RS01165	COG5554	nitrogen fixation
E6C72_RS01190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E6C72_RS01225	COG0745	RESPONSE REGULATOR receiver
E6C72_RS01230	COG2176	DNA-directed DNA polymerase activity
E6C72_RS01230	COG5002	protein histidine kinase activity
E6C72_RS01240	COG5002	protein histidine kinase activity
E6C72_RS01245	COG2204	response regulator
E6C72_RS01250	COG3852	Histidine kinase
E6C72_RS01260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E6C72_RS01305	COG0752	glycyl-tRNA synthetase alpha subunit
E6C72_RS01310	COG0751	glycine-tRNA ligase activity
E6C72_RS01340	COG3437	response regulator, receiver
E6C72_RS01340	COG2770	Histidine kinase
E6C72_RS01345	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E6C72_RS01350	COG1234	tRNA 3'-trailer cleavage
E6C72_RS01355	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E6C72_RS01360	COG0047	phosphoribosylformylglycinamidine synthase activity
E6C72_RS01365	COG0004	ammonium transporteR
E6C72_RS01370	COG0312	modulator of DNA gyrase
E6C72_RS01390	COG1846	Transcriptional regulator
E6C72_RS01400	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E6C72_RS01440	COG0463	Glycosyl transferase, family 2
E6C72_RS01465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E6C72_RS01475	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
E6C72_RS01480	COG3118	belongs to the thioredoxin family
E6C72_RS01490	COG2835	tetraacyldisaccharide 4'-kinase activity
E6C72_RS01500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E6C72_RS01515	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS01520	COG0183	Belongs to the thiolase family
E6C72_RS01525	COG3243	poly(R)-hydroxyalkanoic acid synthase
E6C72_RS01530	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
E6C72_RS01565	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
E6C72_RS01570	COG0842	Transport permease protein
E6C72_RS01575	COG1132	(ABC) transporter
E6C72_RS01580	COG0254	rRNA binding
E6C72_RS01590	COG0071	Belongs to the small heat shock protein (HSP20) family
E6C72_RS01605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E6C72_RS01610	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E6C72_RS01615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E6C72_RS01625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E6C72_RS01640	COG0793	Belongs to the peptidase S41A family
E6C72_RS01645	COG4942	peptidase
E6C72_RS01650	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E6C72_RS01655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E6C72_RS01660	COG0799	negative regulation of ribosome biogenesis
E6C72_RS01680	COG1051	belongs to the nudix hydrolase family
E6C72_RS01690	COG0745	RESPONSE REGULATOR receiver
E6C72_RS01695	COG2198	Histidine kinase
E6C72_RS01695	COG0643	Histidine kinase
E6C72_RS01700	COG0835	chemotaxis
E6C72_RS01705	COG0840	transmembrane signaling receptor activity
E6C72_RS01715	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E6C72_RS01720	COG2201	protein-glutamate methylesterase activity
E6C72_RS01730	COG1366	Belongs to the anti-sigma-factor antagonist family
E6C72_RS01745	COG0745	RESPONSE REGULATOR receiver
E6C72_RS01750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E6C72_RS01755	COG0579	oxidoreductase
E6C72_RS01760	COG0071	Belongs to the small heat shock protein (HSP20) family
E6C72_RS01790	COG1322	Protein conserved in bacteria
E6C72_RS01805	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS01810	COG0436	Aminotransferase
E6C72_RS01855	COG1278	Cold shock
E6C72_RS01860	COG1902	pentaerythritol trinitrate reductase activity
E6C72_RS01870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E6C72_RS01890	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E6C72_RS01900	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E6C72_RS01905	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E6C72_RS01920	COG2193	ferroxidase activity
E6C72_RS01930	COG1192	Involved in chromosome partitioning
E6C72_RS01935	COG0009	L-threonylcarbamoyladenylate synthase
E6C72_RS01940	COG0277	FAD linked oxidase domain protein
E6C72_RS01945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E6C72_RS01950	COG0431	NADPH-dependent FMN reductase
E6C72_RS01960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E6C72_RS01965	COG0747	negative chemotaxis
E6C72_RS01980	COG0101	tRNA pseudouridine synthase activity
E6C72_RS01985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E6C72_RS01990	COG0242	peptide deformylase activity
E6C72_RS01995	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E6C72_RS02010	COG0513	Belongs to the DEAD box helicase family
E6C72_RS02020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E6C72_RS02025	COG1199	ATP-dependent helicase activity
E6C72_RS02025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E6C72_RS02040	COG0679	Auxin Efflux Carrier
E6C72_RS02050	COG2084	Dehydrogenase
E6C72_RS02060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E6C72_RS02075	COG1595	DNA-templated transcription, initiation
E6C72_RS02090	COG2203	Gaf domain
E6C72_RS02090	COG3706	GGDEF domain
E6C72_RS02090	COG4251	negative regulation of phosphorylation
E6C72_RS02090	COG5001	Diguanylate cyclase
E6C72_RS02110	COG3279	Response regulator of the LytR AlgR family
E6C72_RS02120	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E6C72_RS02135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C72_RS02150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C72_RS02165	COG2350	Protein conserved in bacteria
E6C72_RS02185	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E6C72_RS02190	COG2205	protein histidine kinase activity
E6C72_RS02200	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E6C72_RS02210	COG2885	chlorophyll binding
E6C72_RS02220	COG0586	Pfam SNARE associated Golgi protein
E6C72_RS02240	COG1278	Cold shock
E6C72_RS02285	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS02300	COG3327	negative regulation of DNA-templated transcription, initiation
E6C72_RS02315	COG0840	transmembrane signaling receptor activity
E6C72_RS02325	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E6C72_RS02340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E6C72_RS02355	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E6C72_RS02360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E6C72_RS02370	COG0167	dihydroorotate dehydrogenase activity
E6C72_RS02435	COG2032	superoxide dismutase activity
E6C72_RS02440	COG0513	Belongs to the DEAD box helicase family
E6C72_RS02465	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E6C72_RS02475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E6C72_RS02495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E6C72_RS02505	COG4974	Belongs to the 'phage' integrase family
E6C72_RS02510	COG0840	transmembrane signaling receptor activity
E6C72_RS02520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E6C72_RS02540	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS02545	COG0534	Mate efflux family protein
E6C72_RS02550	COG1309	transcriptional regulator
E6C72_RS02570	COG4191	Histidine kinase
E6C72_RS02580	COG4106	trans-aconitate 2-methyltransferase activity
E6C72_RS02595	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E6C72_RS02605	COG0181	hydroxymethylbilane synthase activity
E6C72_RS02635	COG1442	glycosyl transferase family 8
E6C72_RS02635	COG1216	Glycosyl transferase, family 2
E6C72_RS02660	COG1842	Phage shock protein A
E6C72_RS02665	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E6C72_RS02670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E6C72_RS02680	COG0825	malonyl-CoA metabolic process
E6C72_RS02685	COG2239	Acts as a magnesium transporter
E6C72_RS02700	COG0671	phosphoesterase, PA-phosphatase related
E6C72_RS02725	COG1254	Belongs to the acylphosphatase family
E6C72_RS02730	COG0318	PFAM AMP-dependent synthetase and ligase
E6C72_RS02745	COG2719	SpoVR family
E6C72_RS02750	COG2718	Belongs to the UPF0229 family
E6C72_RS02755	COG2766	serine protein kinase
E6C72_RS02770	COG3474	cytochrome
E6C72_RS02775	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E6C72_RS02780	COG0077	Prephenate dehydratase
E6C72_RS02805	COG4166	transmembrane transport
E6C72_RS02810	COG4166	transmembrane transport
E6C72_RS02815	COG4174	ABC transporter (Permease)
E6C72_RS02820	COG4239	(ABC) transporter, permease
E6C72_RS02825	COG4172	Belongs to the ABC transporter superfamily
E6C72_RS02830	COG1703	isobutyryl-CoA mutase activity
E6C72_RS02840	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E6C72_RS02845	COG2137	regulation of response to DNA damage stimulus
E6C72_RS02850	COG0842	Transport permease protein
E6C72_RS02855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E6C72_RS02860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E6C72_RS02890	COG3158	transport of potassium into the cell
E6C72_RS02915	COG0587	DNA-directed DNA polymerase activity
E6C72_RS02940	COG0126	phosphoglycerate kinase activity
E6C72_RS02955	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E6C72_RS02960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E6C72_RS02980	COG1177	transmembrane transport
E6C72_RS03000	COG0156	8-amino-7-oxononanoate synthase activity
E6C72_RS03010	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E6C72_RS03020	COG0135	phosphoribosylanthranilate isomerase activity
E6C72_RS03040	COG0840	transmembrane signaling receptor activity
E6C72_RS03045	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS03060	COG1793	dna ligase
E6C72_RS03070	COG2313	pseudouridylate synthase activity
E6C72_RS03085	COG0753	catalase activity
E6C72_RS03095	COG1741	Belongs to the pirin family
E6C72_RS03100	COG0004	ammonium transporteR
E6C72_RS03105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E6C72_RS03110	COG0297	glycogen (starch) synthase activity
E6C72_RS03130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C72_RS03130	COG0574	Belongs to the PEP-utilizing enzyme family
E6C72_RS03140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E6C72_RS03150	COG0539	negative regulation of cytoplasmic translation
E6C72_RS03210	COG1238	metal cluster binding
E6C72_RS03215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E6C72_RS03225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E6C72_RS03235	COG1674	ftsk spoiiie
E6C72_RS03240	COG2318	DinB family
E6C72_RS03250	COG5002	protein histidine kinase activity
E6C72_RS03275	COG0243	molybdopterin cofactor binding
E6C72_RS03285	COG3005	denitrification pathway
E6C72_RS03310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E6C72_RS03315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E6C72_RS03330	COG1522	sequence-specific DNA binding
E6C72_RS03335	COG3660	Nucleoside-diphosphate-sugar epimerase
E6C72_RS03380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E6C72_RS03390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E6C72_RS03395	COG0861	Integral membrane protein TerC family
E6C72_RS03410	COG0583	DNA-binding transcription factor activity
E6C72_RS03435	COG0138	bifunctional purine biosynthesis protein purh
E6C72_RS03445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E6C72_RS03445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E6C72_RS03455	COG1024	Enoyl-CoA hydratase
E6C72_RS03465	COG0477	Major facilitator Superfamily
E6C72_RS03470	COG0583	DNA-binding transcription factor activity
E6C72_RS03490	COG1272	protein, Hemolysin III
E6C72_RS03515	COG0137	argininosuccinate synthase activity
E6C72_RS03520	COG0840	transmembrane signaling receptor activity
E6C72_RS03525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E6C72_RS03530	COG0840	transmembrane signaling receptor activity
E6C72_RS03540	COG0783	Belongs to the Dps family
E6C72_RS03565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C72_RS03580	COG0776	regulation of translation
E6C72_RS03590	COG2423	ornithine cyclodeaminase activity
E6C72_RS03595	COG3920	Histidine kinase
E6C72_RS03690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E6C72_RS03700	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E6C72_RS03725	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E6C72_RS03740	COG2770	Histidine kinase
E6C72_RS03740	COG3437	response regulator, receiver
E6C72_RS03745	COG3813	Protein conserved in bacteria
E6C72_RS03750	COG0625	glutathione transferase activity
E6C72_RS03755	COG1473	amidohydrolase
E6C72_RS03765	COG5001	Diguanylate cyclase
E6C72_RS03785	COG4106	trans-aconitate 2-methyltransferase activity
E6C72_RS03805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E6C72_RS03815	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
E6C72_RS03825	COG3162	membrane
E6C72_RS03850	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E6C72_RS03860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E6C72_RS03865	COG0542	response to heat
E6C72_RS03885	COG2890	protein-(glutamine-N5) methyltransferase activity
E6C72_RS03895	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E6C72_RS03900	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E6C72_RS03940	COG0739	heme binding
E6C72_RS03960	COG0386	Belongs to the glutathione peroxidase family
E6C72_RS03965	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E6C72_RS03970	COG4133	protoheme IX ABC transporter activity
E6C72_RS04005	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E6C72_RS04010	COG0792	nuclease activity
E6C72_RS04025	COG0180	Tryptophanyl-tRNA synthetase
E6C72_RS04030	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E6C72_RS04045	COG0606	chelatase, subunit chli
E6C72_RS04090	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E6C72_RS04105	COG0730	response to heat
E6C72_RS04120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E6C72_RS04135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E6C72_RS04155	COG0668	transmembrane transport
E6C72_RS04160	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E6C72_RS04170	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E6C72_RS04175	COG0302	gtp cyclohydrolase
E6C72_RS04180	COG2967	ApaG domain
E6C72_RS04190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E6C72_RS04195	COG1702	phosphate starvation-inducible protein PhoH
E6C72_RS04205	COG1253	flavin adenine dinucleotide binding
E6C72_RS04210	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E6C72_RS04215	COG1396	sequence-specific DNA binding
E6C72_RS04220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E6C72_RS04225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E6C72_RS04230	COG2329	Antibiotic biosynthesis monooxygenase
E6C72_RS04235	COG0779	Required for maturation of 30S ribosomal subunits
E6C72_RS04260	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E6C72_RS04265	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E6C72_RS04270	COG1185	polyribonucleotide nucleotidyltransferase activity
E6C72_RS04275	COG2378	regulation of single-species biofilm formation
E6C72_RS04290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E6C72_RS04300	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E6C72_RS04305	COG1138	Cytochrome C-type biogenesis protein
E6C72_RS04310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E6C72_RS04315	COG3088	subunit of a heme lyase
E6C72_RS04320	COG4235	cytochrome complex assembly
E6C72_RS04325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E6C72_RS04385	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E6C72_RS04390	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E6C72_RS04395	COG4395	Tim44
E6C72_RS04405	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E6C72_RS04410	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E6C72_RS04415	COG1981	membrane
E6C72_RS04445	COG0237	dephospho-CoA kinase activity
E6C72_RS04450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E6C72_RS04465	COG1331	Highly conserved protein containing a thioredoxin domain
E6C72_RS04485	COG0445	tRNA wobble uridine modification
E6C72_RS04490	COG0357	Ribosomal RNA small subunit methyltransferase G
E6C72_RS04505	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E6C72_RS04510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E6C72_RS04515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E6C72_RS04520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E6C72_RS04525	COG2814	Major facilitator Superfamily
E6C72_RS04530	COG0280	phosphate acetyltransferase
E6C72_RS04530	COG0281	malic enzyme
E6C72_RS04555	COG5002	protein histidine kinase activity
E6C72_RS04560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E6C72_RS04565	COG0573	inorganic phosphate transmembrane transporter activity
E6C72_RS04575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E6C72_RS04580	COG0745	RESPONSE REGULATOR receiver
E6C72_RS04590	COG0670	Belongs to the BI1 family
E6C72_RS04605	COG4181	ATPase activity
E6C72_RS04620	COG0667	Aldo Keto reductase
E6C72_RS04625	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E6C72_RS04630	COG3706	GGDEF domain
E6C72_RS04635	COG0484	heat shock protein binding
E6C72_RS04640	COG0443	Heat shock 70 kDa protein
E6C72_RS04660	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E6C72_RS04670	COG0456	acetyltransferase
E6C72_RS04725	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E6C72_RS04735	COG0745	RESPONSE REGULATOR receiver
E6C72_RS04740	COG0642	Histidine kinase
E6C72_RS04760	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C72_RS04760	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E6C72_RS04770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C72_RS04785	COG0501	Belongs to the peptidase M48B family
E6C72_RS04790	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E6C72_RS04810	COG0271	Belongs to the BolA IbaG family
E6C72_RS04835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E6C72_RS04855	COG4974	Belongs to the 'phage' integrase family
E6C72_RS04865	COG2154	pterin-4-alpha-carbinolamine dehydratase
E6C72_RS04875	COG1573	uracil-dna glycosylase
E6C72_RS04885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E6C72_RS04890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C72_RS04905	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C72_RS04910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E6C72_RS04970	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E6C72_RS04970	COG0517	IMP dehydrogenase activity
E6C72_RS04985	COG1137	ATPase activity
E6C72_RS04990	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E6C72_RS04995	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E6C72_RS05000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C72_RS05005	COG4636	protein conserved in cyanobacteria
E6C72_RS05010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E6C72_RS05020	COG2070	2-Nitropropane dioxygenase
E6C72_RS05030	COG1733	regulation of RNA biosynthetic process
E6C72_RS05035	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
E6C72_RS05045	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E6C72_RS05070	COG3118	belongs to the thioredoxin family
E6C72_RS05075	COG1074	ATP-dependent DNA helicase activity
E6C72_RS05080	COG2887	Belongs to the helicase family. UvrD subfamily
E6C72_RS05085	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E6C72_RS05090	COG3178	'Phosphotransferase
E6C72_RS05095	COG0802	atpase or kinase
E6C72_RS05110	COG2205	protein histidine kinase activity
E6C72_RS05115	COG5002	protein histidine kinase activity
E6C72_RS05115	COG2205	protein histidine kinase activity
E6C72_RS05115	COG0784	Response regulator, receiver
E6C72_RS05125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E6C72_RS05130	COG2204	response regulator
E6C72_RS05135	COG1278	Cold shock
E6C72_RS05140	COG2205	protein histidine kinase activity
E6C72_RS05140	COG0784	Response regulator, receiver
E6C72_RS05145	COG0133	tryptophan synthase activity
E6C72_RS05155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E6C72_RS05160	COG0285	dihydrofolate synthase activity
E6C72_RS05175	COG1872	DUF167
E6C72_RS05180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E6C72_RS05185	COG0598	Magnesium transport protein CorA
E6C72_RS05205	COG0039	L-malate dehydrogenase activity
E6C72_RS05230	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E6C72_RS05235	COG4166	transmembrane transport
E6C72_RS05240	COG0747	negative chemotaxis
E6C72_RS05250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C72_RS05260	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E6C72_RS05285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E6C72_RS05295	COG1024	Enoyl-CoA hydratase
E6C72_RS05300	COG0268	Binds directly to 16S ribosomal RNA
E6C72_RS05305	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E6C72_RS05310	COG3706	GGDEF domain
E6C72_RS05315	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E6C72_RS05320	COG3842	ATPase activity
E6C72_RS05330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E6C72_RS05350	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E6C72_RS05380	COG2264	protein methyltransferase activity
E6C72_RS05410	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E6C72_RS05480	COG0406	alpha-ribazole phosphatase activity
E6C72_RS05500	COG0745	RESPONSE REGULATOR receiver
E6C72_RS05580	COG1509	lysine 2,3-aminomutase activity
E6C72_RS05585	COG0584	glycerophosphoryl diester phosphodiesterase
E6C72_RS05610	COG2202	Pas domain
E6C72_RS05610	COG2205	protein histidine kinase activity
E6C72_RS05620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E6C72_RS05625	COG3162	membrane
E6C72_RS05640	COG0318	PFAM AMP-dependent synthetase and ligase
E6C72_RS05655	COG1960	acyl-CoA dehydrogenase activity
E6C72_RS05660	COG1187	pseudouridine synthase activity
E6C72_RS05670	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E6C72_RS05680	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E6C72_RS05685	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E6C72_RS05690	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E6C72_RS05705	COG0784	Response regulator, receiver
E6C72_RS05705	COG3437	response regulator, receiver
E6C72_RS05715	COG0583	DNA-binding transcription factor activity
E6C72_RS05725	COG0252	asparaginase activity
E6C72_RS05750	COG1643	Atp-dependent helicase
E6C72_RS05785	COG4191	Histidine kinase
E6C72_RS05800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E6C72_RS05805	COG0045	succinate-CoA ligase (ADP-forming) activity
E6C72_RS05810	COG0039	L-malate dehydrogenase activity
E6C72_RS05840	COG0640	Transcriptional regulator
E6C72_RS05855	COG1970	mechanosensitive ion channel activity
E6C72_RS05860	COG0653	protein targeting
E6C72_RS05865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E6C72_RS05870	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E6C72_RS05875	COG0494	nUDIX hydrolase
E6C72_RS05885	COG0514	ATP-dependent DNA helicase (RecQ)
E6C72_RS05895	COG0024	Methionine aminopeptidase
E6C72_RS05900	COG1489	DNA binding
E6C72_RS05905	COG1058	Belongs to the CinA family
E6C72_RS05905	COG1546	Belongs to the CinA family
E6C72_RS05925	COG0745	RESPONSE REGULATOR receiver
E6C72_RS05950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E6C72_RS05955	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E6C72_RS05965	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E6C72_RS05970	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E6C72_RS05980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E6C72_RS05990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E6C72_RS06005	COG3278	Belongs to the heme-copper respiratory oxidase family
E6C72_RS06040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C72_RS06045	COG1612	heme a metabolic process
E6C72_RS06050	COG3772	lysozyme
E6C72_RS06060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E6C72_RS06065	COG0459	protein refolding
E6C72_RS06080	COG4566	intracellular signal transduction
E6C72_RS06100	COG0583	DNA-binding transcription factor activity
E6C72_RS06120	COG4608	Belongs to the ABC transporter superfamily
E6C72_RS06125	COG0444	Belongs to the ABC transporter superfamily
E6C72_RS06130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C72_RS06135	COG0601	transmembrane transport
E6C72_RS06140	COG0492	ferredoxin-NADP+ reductase activity
E6C72_RS06150	COG1695	Transcriptional regulator
E6C72_RS06165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E6C72_RS06175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E6C72_RS06190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E6C72_RS06195	COG1595	DNA-templated transcription, initiation
E6C72_RS06205	COG3830	Belongs to the UPF0237 family
E6C72_RS06205	COG0560	Phosphoserine phosphatase
E6C72_RS06220	COG2202	Pas domain
E6C72_RS06220	COG2205	protein histidine kinase activity
E6C72_RS06240	COG0454	-acetyltransferase
E6C72_RS06240	COG0456	acetyltransferase
E6C72_RS06265	COG0840	transmembrane signaling receptor activity
E6C72_RS06265	COG3290	protein histidine kinase activity
E6C72_RS06270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C72_RS06270	COG2022	thiamine diphosphate biosynthetic process
E6C72_RS06280	COG2022	thiamine diphosphate biosynthetic process
E6C72_RS06365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E6C72_RS06370	COG3108	Peptidase M15
E6C72_RS06380	COG3038	cytochrome b561
E6C72_RS06390	COG2205	protein histidine kinase activity
E6C72_RS06395	COG0745	RESPONSE REGULATOR receiver
E6C72_RS06400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E6C72_RS06420	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E6C72_RS06425	COG0277	FAD linked oxidase domain protein
E6C72_RS06430	COG0277	FAD linked oxidase domain protein
E6C72_RS06435	COG0247	lactate metabolic process
E6C72_RS06460	COG1454	alcohol dehydrogenase
E6C72_RS06465	COG1960	acyl-CoA dehydrogenase activity
E6C72_RS06485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E6C72_RS06490	COG2171	N-acyltransferase activity
E6C72_RS06525	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E6C72_RS06530	COG0228	four-way junction DNA binding
E6C72_RS06535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E6C72_RS06540	COG0336	Belongs to the RNA methyltransferase TrmD family
E6C72_RS06545	COG0335	large ribosomal subunit rRNA binding
E6C72_RS06550	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E6C72_RS06560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E6C72_RS06565	COG0706	membrane insertase activity
E6C72_RS06570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E6C72_RS06580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E6C72_RS06595	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E6C72_RS06605	COG1530	ribonuclease E activity
E6C72_RS06610	COG0860	N-Acetylmuramoyl-L-alanine amidase
E6C72_RS06660	COG1940	carbohydrate kinase activity
E6C72_RS06690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C72_RS06695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C72_RS06795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E6C72_RS06815	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E6C72_RS06820	COG0081	regulation of translation
E6C72_RS06825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E6C72_RS06830	COG0222	ribosome binding
E6C72_RS06835	COG0085	RNA polymerase activity
E6C72_RS06840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E6C72_RS06850	COG0049	tRNA binding
E6C72_RS06860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E6C72_RS06865	COG0051	transcription antitermination factor activity, RNA binding
E6C72_RS06875	COG0088	Forms part of the polypeptide exit tunnel
E6C72_RS06880	COG0089	rRNA binding
E6C72_RS06885	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E6C72_RS06890	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E6C72_RS06895	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E6C72_RS06900	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E6C72_RS06905	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E6C72_RS06910	COG0255	Belongs to the universal ribosomal protein uL29 family
E6C72_RS06915	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E6C72_RS06925	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E6C72_RS06935	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E6C72_RS06940	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E6C72_RS06945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E6C72_RS06955	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E6C72_RS06960	COG1841	ribosomal large subunit assembly
E6C72_RS06965	COG0200	Binds to the 23S rRNA
E6C72_RS06975	COG0563	adenylate kinase activity
E6C72_RS06985	COG0697	spore germination
E6C72_RS07000	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E6C72_RS07005	COG3842	ATPase activity
E6C72_RS07025	COG2267	carboxylic ester hydrolase activity
E6C72_RS07035	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E6C72_RS07080	COG1285	pathogenesis
E6C72_RS07090	COG0196	riboflavin kinase activity
E6C72_RS07095	COG2030	dehydratase
E6C72_RS07100	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E6C72_RS07105	COG2267	carboxylic ester hydrolase activity
E6C72_RS07115	COG0628	permease
E6C72_RS07145	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E6C72_RS07150	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E6C72_RS07160	COG1597	lipid kinase activity
E6C72_RS07175	COG1280	lysine exporter protein (LysE YggA)
E6C72_RS07180	COG3706	GGDEF domain
E6C72_RS07180	COG2203	Gaf domain
E6C72_RS07180	COG5001	Diguanylate cyclase
E6C72_RS07180	COG4251	negative regulation of phosphorylation
E6C72_RS07185	COG1519	Transferase
E6C72_RS07185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E6C72_RS07190	COG1663	tetraacyldisaccharide 4'-kinase activity
E6C72_RS07200	COG1280	lysine exporter protein (LysE YggA)
E6C72_RS07210	COG2205	protein histidine kinase activity
E6C72_RS07210	COG5002	protein histidine kinase activity
E6C72_RS07210	COG0784	Response regulator, receiver
E6C72_RS07220	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E6C72_RS07225	COG0644	oxidoreductase
E6C72_RS07280	COG1902	pentaerythritol trinitrate reductase activity
E6C72_RS07290	COG2962	Rard protein
E6C72_RS07295	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E6C72_RS07305	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E6C72_RS07320	COG2205	protein histidine kinase activity
E6C72_RS07335	COG0395	ABC-type sugar transport system, permease component
E6C72_RS07340	COG3842	ATPase activity
E6C72_RS07345	COG5508	conserved small protein
E6C72_RS07350	COG0501	Belongs to the peptidase M48B family
E6C72_RS07400	COG1366	Belongs to the anti-sigma-factor antagonist family
E6C72_RS07425	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E6C72_RS07450	COG1686	Belongs to the peptidase S11 family
E6C72_RS07465	COG2205	protein histidine kinase activity
E6C72_RS07465	COG2202	Pas domain
E6C72_RS07470	COG5002	protein histidine kinase activity
E6C72_RS07475	COG2205	protein histidine kinase activity
E6C72_RS07485	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E6C72_RS07500	COG0166	Belongs to the GPI family
E6C72_RS07505	COG0612	Peptidase, M16
E6C72_RS07510	COG0612	Peptidase, M16
E6C72_RS07520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E6C72_RS07555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E6C72_RS07560	COG2703	oxygen carrier activity
E6C72_RS07565	COG0840	transmembrane signaling receptor activity
E6C72_RS07575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E6C72_RS07590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C72_RS07620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E6C72_RS07625	COG0746	molybdenum cofactor guanylyltransferase activity
E6C72_RS07650	COG3383	formate dehydrogenase (NAD+) activity
E6C72_RS07655	COG0437	4 iron, 4 sulfur cluster binding
E6C72_RS07670	COG0235	Class ii aldolase
E6C72_RS07675	COG5002	protein histidine kinase activity
E6C72_RS07675	COG0784	Response regulator, receiver
E6C72_RS07680	COG3384	dioxygenase
E6C72_RS07685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E6C72_RS07690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E6C72_RS07695	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E6C72_RS07700	COG0356	it plays a direct role in the translocation of protons across the membrane
E6C72_RS07710	COG1999	signal sequence binding
E6C72_RS07720	COG1702	phosphate starvation-inducible protein PhoH
E6C72_RS07725	COG0850	regulation of cytokinetic process
E6C72_RS07730	COG2894	cell division
E6C72_RS07735	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E6C72_RS07760	COG4948	Mandelate Racemase Muconate Lactonizing
E6C72_RS07765	COG2154	pterin-4-alpha-carbinolamine dehydratase
E6C72_RS07770	COG1573	uracil-dna glycosylase
E6C72_RS07795	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E6C72_RS07805	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
E6C72_RS07810	COG5420	small protein containing a coiled-coil domain
E6C72_RS07825	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
E6C72_RS07830	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
E6C72_RS07880	COG0121	glutamine amidotransferase
E6C72_RS07890	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E6C72_RS07895	COG0552	protein localization to endoplasmic reticulum
E6C72_RS07900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E6C72_RS07905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E6C72_RS07925	COG0583	DNA-binding transcription factor activity
E6C72_RS07960	COG2301	Belongs to the HpcH HpaI aldolase family
E6C72_RS07965	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E6C72_RS07970	COG2205	protein histidine kinase activity
E6C72_RS07970	COG2202	Pas domain
E6C72_RS07975	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E6C72_RS07985	COG2972	Histidine kinase
E6C72_RS07985	COG0840	transmembrane signaling receptor activity
E6C72_RS07995	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E6C72_RS08000	COG1063	alcohol dehydrogenase
E6C72_RS08010	COG0596	Alpha beta hydrolase
E6C72_RS08010	COG0508	dehydrogenase complex catalyzes the overall conversion of
E6C72_RS08015	COG0022	dehydrogenase e1 component
E6C72_RS08020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E6C72_RS08025	COG3199	ATP-NAD kinase
E6C72_RS08030	COG0277	FAD linked oxidase domain protein
E6C72_RS08040	COG1671	Belongs to the UPF0178 family
E6C72_RS08045	COG0488	(ABC) transporter
E6C72_RS08075	COG2853	Lipoprotein
E6C72_RS08085	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E6C72_RS08095	COG0646	methionine synthase
E6C72_RS08095	COG1410	methionine synthase
E6C72_RS08120	COG3706	GGDEF domain
E6C72_RS08125	COG2070	2-Nitropropane dioxygenase
E6C72_RS08130	COG0488	(ABC) transporter
E6C72_RS08135	COG0583	DNA-binding transcription factor activity
E6C72_RS08140	COG2814	Major facilitator Superfamily
E6C72_RS08165	COG0175	sulfate reduction
E6C72_RS08170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E6C72_RS08170	COG1648	precorrin-2 dehydrogenase activity
E6C72_RS08180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E6C72_RS08190	COG3108	Peptidase M15
E6C72_RS08200	COG2205	protein histidine kinase activity
E6C72_RS08200	COG2202	Pas domain
E6C72_RS08205	COG4566	intracellular signal transduction
E6C72_RS08235	COG0243	molybdopterin cofactor binding
E6C72_RS08240	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E6C72_RS08240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E6C72_RS08250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E6C72_RS08260	COG0612	Peptidase, M16
E6C72_RS08290	COG0483	inositol monophosphate 1-phosphatase activity
E6C72_RS08295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E6C72_RS08310	COG0730	response to heat
E6C72_RS08315	COG0352	thiamine-phosphate diphosphorylase activity
E6C72_RS08320	COG1830	Aldolase
E6C72_RS08370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E6C72_RS08375	COG1692	metallophosphoesterase
E6C72_RS08380	COG0217	transcriptional regulatory protein
E6C72_RS08390	COG0632	four-way junction helicase activity
E6C72_RS08395	COG2255	four-way junction helicase activity
E6C72_RS08400	COG0824	Thioesterase
E6C72_RS08410	COG0848	biopolymer transport protein
E6C72_RS08425	COG2885	chlorophyll binding
E6C72_RS08435	COG0037	tRNA processing
E6C72_RS08440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E6C72_RS08450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E6C72_RS08455	COG1295	ribonuclease BN
E6C72_RS08470	COG4520	surface antigen
E6C72_RS08475	COG0259	pyridoxamine-phosphate oxidase activity
E6C72_RS08505	COG2153	protein acetylation
E6C72_RS08520	COG3685	Protein conserved in bacteria
E6C72_RS08535	COG4957	zinc ion binding
E6C72_RS08540	COG0698	ribose 5-phosphate isomerase
E6C72_RS08545	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E6C72_RS08550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E6C72_RS08555	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E6C72_RS08570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E6C72_RS08580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E6C72_RS08580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E6C72_RS08590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E6C72_RS08590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E6C72_RS08610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E6C72_RS08615	COG0416	fatty acid biosynthetic process
E6C72_RS08620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E6C72_RS08640	COG1764	response to oxidative stress
E6C72_RS08645	COG1846	Transcriptional regulator
E6C72_RS08650	COG0456	acetyltransferase
E6C72_RS08660	COG2890	protein-(glutamine-N5) methyltransferase activity
E6C72_RS08665	COG1393	Belongs to the ArsC family
E6C72_RS08670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E6C72_RS08680	COG1403	HNH endonuclease
E6C72_RS08705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E6C72_RS08750	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E6C72_RS08775	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E6C72_RS08785	COG3108	Peptidase M15
E6C72_RS08810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E6C72_RS08815	COG0511	ligase activity, forming carbon-carbon bonds
E6C72_RS08820	COG0439	Biotin carboxylase
E6C72_RS08825	COG0840	transmembrane signaling receptor activity
E6C72_RS08830	COG4251	negative regulation of phosphorylation
E6C72_RS08835	COG4251	negative regulation of phosphorylation
E6C72_RS08840	COG0784	Response regulator, receiver
E6C72_RS08855	COG0745	RESPONSE REGULATOR receiver
E6C72_RS08875	COG0432	Pfam Uncharacterised protein family UPF0047
E6C72_RS08880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C72_RS08890	COG2205	protein histidine kinase activity
E6C72_RS08895	COG0628	permease
E6C72_RS08905	COG0616	signal peptide processing
E6C72_RS08915	COG0745	RESPONSE REGULATOR receiver
E6C72_RS08925	COG0436	Aminotransferase
E6C72_RS08935	COG1494	fructose-1,6-bisphosphatase
E6C72_RS08955	COG1324	tolerance protein
E6C72_RS08960	COG0303	'Molybdopterin
E6C72_RS08965	COG0583	DNA-binding transcription factor activity
E6C72_RS08980	COG2373	Large extracellular alpha-helical protein
E6C72_RS08985	COG4953	penicillin-binding protein 1C
E6C72_RS09000	COG2132	Multicopper oxidase
E6C72_RS09010	COG1914	H( )-stimulated, divalent metal cation uptake system
E6C72_RS09050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E6C72_RS09050	COG0519	Catalyzes the synthesis of GMP from XMP
E6C72_RS09055	COG1247	-acetyltransferase
E6C72_RS09065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E6C72_RS09080	COG1758	RNA polymerase activity
E6C72_RS09095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E6C72_RS09100	COG0736	holo-[acyl-carrier-protein] synthase activity
E6C72_RS09105	COG0681	Belongs to the peptidase S26 family
E6C72_RS09110	COG0571	ribonuclease III activity
E6C72_RS09115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E6C72_RS09130	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E6C72_RS09140	COG1752	Esterase of the alpha-beta hydrolase superfamily
E6C72_RS09165	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E6C72_RS09175	COG1338	Plays a role in the flagellum-specific transport system
E6C72_RS09190	COG2257	FlhB HrpN YscU SpaS Family
E6C72_RS09195	COG1815	bacterial-type flagellum-dependent cell motility
E6C72_RS09200	COG1558	bacterial-type flagellum-dependent cell motility
E6C72_RS09205	COG1677	Flagellar hook-basal body complex protein FliE
E6C72_RS09220	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E6C72_RS09255	COG2010	Cytochrome c
E6C72_RS09270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E6C72_RS09280	COG2076	Multidrug Resistance protein
E6C72_RS09285	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E6C72_RS09300	COG0312	modulator of DNA gyrase
E6C72_RS09310	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E6C72_RS09315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E6C72_RS09320	COG0109	protoheme IX farnesyltransferase activity
E6C72_RS09330	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E6C72_RS09335	COG1845	cytochrome c oxidase, subunit III
E6C72_RS09345	COG3346	SURF1 family
E6C72_RS09355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E6C72_RS09360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E6C72_RS09365	COG3237	CsbD-like
E6C72_RS09380	COG1742	UPF0060 membrane protein
E6C72_RS09390	COG5001	Diguanylate cyclase
E6C72_RS09395	COG1840	ABC-type Fe3 transport system, periplasmic component
E6C72_RS09400	COG3842	ATPase activity
E6C72_RS09405	COG1132	(ABC) transporter
E6C72_RS09410	COG1752	Esterase of the alpha-beta hydrolase superfamily
E6C72_RS09430	COG1178	ABC-type Fe3 transport system permease component
E6C72_RS09435	COG1217	gtp-binding protein TYPA
E6C72_RS09450	COG2226	methyltransferase
E6C72_RS09465	COG1196	nuclear chromosome segregation
E6C72_RS09465	COG0741	lytic transglycosylase activity
E6C72_RS09465	COG0739	heme binding
E6C72_RS09475	COG5487	UPF0391 membrane protein
E6C72_RS09485	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E6C72_RS09490	COG1765	OsmC-like protein
E6C72_RS09510	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E6C72_RS09515	COG0728	peptidoglycan biosynthetic process
E6C72_RS09520	COG2205	protein histidine kinase activity
E6C72_RS09540	COG2086	electron transfer activity
E6C72_RS09550	COG0789	Transcriptional regulator
E6C72_RS09555	COG0318	PFAM AMP-dependent synthetase and ligase
E6C72_RS09575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E6C72_RS09580	COG1360	Flagellar Motor Protein
E6C72_RS09585	COG2308	Evidence 4 Homologs of previously reported genes of
E6C72_RS09605	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E6C72_RS09605	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C72_RS09625	COG0626	cystathionine gamma-synthase activity
E6C72_RS09630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C72_RS09635	COG4597	amino acid ABC transporter
E6C72_RS09640	COG0765	amino acid transport
E6C72_RS09645	COG1126	abc transporter atp-binding protein
E6C72_RS09650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E6C72_RS09665	COG0456	acetyltransferase
E6C72_RS09665	COG0454	-acetyltransferase
E6C72_RS09670	COG2897	thiosulfate sulfurtransferase activity
E6C72_RS09685	COG0494	nUDIX hydrolase
E6C72_RS09690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C72_RS09720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E6C72_RS09730	COG1538	Outer membrane efflux protein
E6C72_RS09740	COG0525	valine-tRNA ligase activity
E6C72_RS09750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E6C72_RS09755	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E6C72_RS09765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E6C72_RS09770	COG0628	permease
E6C72_RS09780	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS09785	COG1846	Transcriptional regulator
E6C72_RS09825	COG1396	sequence-specific DNA binding
E6C72_RS09910	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E6C72_RS09915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E6C72_RS09950	COG1366	Belongs to the anti-sigma-factor antagonist family
E6C72_RS09955	COG2208	phosphoserine phosphatase activity
E6C72_RS09965	COG5002	protein histidine kinase activity
E6C72_RS09965	COG2205	protein histidine kinase activity
E6C72_RS09965	COG0784	Response regulator, receiver
E6C72_RS09970	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E6C72_RS09995	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS10000	COG0443	Heat shock 70 kDa protein
E6C72_RS10005	COG0489	protein tyrosine kinase activity
E6C72_RS10010	COG0330	HflC and HflK could
E6C72_RS10015	COG0330	HflC and HflK could
E6C72_RS10020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C72_RS10030	COG2197	response regulator
E6C72_RS10040	COG0745	RESPONSE REGULATOR receiver
E6C72_RS10050	COG1846	Transcriptional regulator
E6C72_RS10060	COG0149	triose-phosphate isomerase activity
E6C72_RS10095	COG1566	PFAM secretion protein HlyD family protein
E6C72_RS10100	COG1136	(ABC) transporter
E6C72_RS10105	COG1136	(ABC) transporter
E6C72_RS10105	COG0577	efflux transmembrane transporter activity
E6C72_RS10135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E6C72_RS10140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E6C72_RS10145	COG0534	Mate efflux family protein
E6C72_RS10160	COG0741	lytic transglycosylase activity
E6C72_RS10165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E6C72_RS10170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E6C72_RS10175	COG2813	Specifically methylates the guanine in position
E6C72_RS10180	COG0667	Aldo Keto reductase
E6C72_RS10195	COG1881	PFAM PEBP family protein
E6C72_RS10200	COG0113	porphobilinogen synthase activity
E6C72_RS10210	COG1597	lipid kinase activity
E6C72_RS10215	COG1024	Enoyl-CoA hydratase
E6C72_RS10220	COG1846	Transcriptional regulator
E6C72_RS10235	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS10250	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E6C72_RS10260	COG2226	methyltransferase
E6C72_RS10275	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS10280	COG0840	transmembrane signaling receptor activity
E6C72_RS10280	COG2972	Histidine kinase
E6C72_RS10290	COG0456	acetyltransferase
E6C72_RS10295	COG0058	SHG alpha-glucan phosphorylase activity
E6C72_RS10300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E6C72_RS10310	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E6C72_RS10320	COG0745	RESPONSE REGULATOR receiver
E6C72_RS10330	COG2307	Protein conserved in bacteria
E6C72_RS10330	COG2308	Evidence 4 Homologs of previously reported genes of
E6C72_RS10390	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E6C72_RS10405	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
E6C72_RS10410	COG2814	Major facilitator Superfamily
E6C72_RS10415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E6C72_RS10425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E6C72_RS10440	COG1862	Preprotein translocase
E6C72_RS10445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E6C72_RS10455	COG3737	Protein of unknown function (DUF498/DUF598)
E6C72_RS10470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E6C72_RS10475	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
E6C72_RS10480	COG1562	ergosterol biosynthetic process
E6C72_RS10485	COG1562	ergosterol biosynthetic process
E6C72_RS10505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E6C72_RS10515	COG2062	phosphohistidine phosphatase, SixA
E6C72_RS10520	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E6C72_RS10525	COG0248	Ppx GppA phosphatase
E6C72_RS10530	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS10540	COG0617	tRNA 3'-terminal CCA addition
E6C72_RS10555	COG0714	Associated with various cellular activities
E6C72_RS10585	COG2226	methyltransferase
E6C72_RS10590	COG2814	Major facilitator Superfamily
E6C72_RS10595	COG0583	DNA-binding transcription factor activity
E6C72_RS10600	COG0629	single-stranded DNA binding
E6C72_RS10630	COG0123	including yeast histone deacetylase and acetoin utilization protein
E6C72_RS10635	COG1116	anion transmembrane transporter activity
E6C72_RS10640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C72_RS10645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E6C72_RS10655	COG0483	inositol monophosphate 1-phosphatase activity
E6C72_RS10670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E6C72_RS10675	COG1923	regulation of RNA biosynthetic process
E6C72_RS10695	COG2204	response regulator
E6C72_RS10735	COG1942	4-Oxalocrotonate Tautomerase
E6C72_RS10740	COG2867	negative regulation of translational initiation
E6C72_RS10745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E6C72_RS10755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E6C72_RS10765	COG0508	dehydrogenase complex catalyzes the overall conversion of
E6C72_RS10770	COG0508	dehydrogenase complex catalyzes the overall conversion of
E6C72_RS10770	COG0022	dehydrogenase e1 component
E6C72_RS10775	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E6C72_RS10795	COG4149	molybdate abc transporter
E6C72_RS10800	COG0725	ABC transporter, periplasmic molybdate-binding protein
E6C72_RS10805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E6C72_RS10810	COG2261	transglycosylase associated protein
E6C72_RS10825	COG2135	peptidase activity
E6C72_RS10835	COG2200	EAL domain
E6C72_RS10835	COG2199	diguanylate cyclase activity
E6C72_RS10835	COG3287	FIST C domain
E6C72_RS10845	COG1218	3'(2'),5'-bisphosphate nucleotidase
E6C72_RS10850	COG2833	Protein of unknown function (DUF455)
E6C72_RS10855	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E6C72_RS10860	COG0328	RNA-DNA hybrid ribonuclease activity
E6C72_RS10865	COG0678	peroxiredoxin activity
E6C72_RS10870	COG2824	Alkylphosphonate utilization operon protein PhnA
E6C72_RS10875	COG4232	protein-disulfide reductase activity
E6C72_RS10880	COG1678	Uncharacterized ACR, COG1678
E6C72_RS10885	COG0314	molybdopterin synthase activity
E6C72_RS10890	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E6C72_RS10900	COG0546	phosphoglycolate phosphatase activity
E6C72_RS10905	COG1763	Mo-molybdopterin cofactor biosynthetic process
E6C72_RS10910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E6C72_RS10920	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS10945	COG4120	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS10960	COG0672	)-iron permease
E6C72_RS10985	COG0583	DNA-binding transcription factor activity
E6C72_RS10990	COG0540	Belongs to the ATCase OTCase family
E6C72_RS10995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E6C72_RS11005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C72_RS11020	COG0776	regulation of translation
E6C72_RS11025	COG4957	zinc ion binding
E6C72_RS11065	COG0741	lytic transglycosylase activity
E6C72_RS11070	COG0556	nucleotide-excision repair
E6C72_RS11075	COG2203	Gaf domain
E6C72_RS11075	COG2199	diguanylate cyclase activity
E6C72_RS11100	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E6C72_RS11105	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E6C72_RS11130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E6C72_RS11135	COG1492	cobalamin metabolic process
E6C72_RS11200	COG0315	cyclic pyranopterin monophosphate synthase activity
E6C72_RS11205	COG0303	'Molybdopterin
E6C72_RS11210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E6C72_RS11215	COG2333	competence protein COMEC
E6C72_RS11215	COG0658	competence protein
E6C72_RS11220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E6C72_RS11235	COG4977	sequence-specific DNA binding
E6C72_RS11245	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E6C72_RS11250	COG3494	Protein of unknown function (DUF1009)
E6C72_RS11275	COG0750	zinc metalloprotease
E6C72_RS11280	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E6C72_RS11290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E6C72_RS11295	COG0233	cytoplasmic translational termination
E6C72_RS11300	COG0528	UMP kinase activity
E6C72_RS11305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E6C72_RS11310	COG0052	Belongs to the universal ribosomal protein uS2 family
E6C72_RS11315	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E6C72_RS11320	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E6C72_RS11330	COG4221	oxidoreductase activity
E6C72_RS11335	COG1561	YicC-like family, N-terminal region
E6C72_RS11370	COG0513	Belongs to the DEAD box helicase family
E6C72_RS11395	COG0187	DNA topoisomerase II activity
E6C72_RS11400	COG1607	acyl-coa hydrolase
E6C72_RS11410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E6C72_RS11415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C72_RS11445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C72_RS11445	COG4191	Histidine kinase
E6C72_RS11460	COG3437	response regulator, receiver
E6C72_RS11460	COG0784	Response regulator, receiver
E6C72_RS11470	COG0140	phosphoribosyl-ATP diphosphatase activity
E6C72_RS11500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E6C72_RS11505	COG2198	Histidine kinase
E6C72_RS11505	COG0643	Histidine kinase
E6C72_RS11510	COG2201	protein-glutamate methylesterase activity
E6C72_RS11515	COG2201	protein-glutamate methylesterase activity
E6C72_RS11530	COG0840	transmembrane signaling receptor activity
E6C72_RS11535	COG0840	transmembrane signaling receptor activity
E6C72_RS11550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E6C72_RS11555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E6C72_RS11570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E6C72_RS11580	COG0360	Binds together with S18 to 16S ribosomal RNA
E6C72_RS11585	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E6C72_RS11595	COG0359	binds to the 23S rRNA
E6C72_RS11605	COG0538	isocitrate dehydrogenase activity
E6C72_RS11615	COG0330	HflC and HflK could
E6C72_RS11635	COG1595	DNA-templated transcription, initiation
E6C72_RS11640	COG0473	3-isopropylmalate dehydrogenase activity
E6C72_RS11670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E6C72_RS11705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E6C72_RS11710	COG4221	oxidoreductase activity
E6C72_RS11715	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E6C72_RS11735	COG0024	Methionine aminopeptidase
E6C72_RS11745	COG4636	protein conserved in cyanobacteria
E6C72_RS11755	COG1160	GTP binding
E6C72_RS11770	COG2197	response regulator
E6C72_RS11780	COG0840	transmembrane signaling receptor activity
E6C72_RS11785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E6C72_RS11840	COG0604	alcohol dehydrogenase
E6C72_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS11840	COG3321	synthase
E6C72_RS11850	COG0163	prenyltransferase activity
E6C72_RS11855	COG0288	reversible hydration of carbon dioxide
E6C72_RS11880	COG0205	6-phosphofructokinase activity
E6C72_RS11895	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E6C72_RS11900	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E6C72_RS11905	COG5001	Diguanylate cyclase
E6C72_RS11925	COG0114	fumarate hydratase activity
E6C72_RS11950	COG2951	lytic endotransglycosylase activity
E6C72_RS11960	COG2197	response regulator
E6C72_RS11975	COG0784	Response regulator, receiver
E6C72_RS11975	COG4191	Histidine kinase
E6C72_RS11985	COG4191	Histidine kinase
E6C72_RS12000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C72_RS12030	COG1366	Belongs to the anti-sigma-factor antagonist family
E6C72_RS12070	COG0745	RESPONSE REGULATOR receiver
E6C72_RS12090	COG0105	UTP biosynthetic process
E6C72_RS12100	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E6C72_RS12110	COG0488	(ABC) transporter
E6C72_RS12115	COG3932	Exopolysaccharide synthesis, ExoD
E6C72_RS12120	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E6C72_RS12140	COG1686	Belongs to the peptidase S11 family
E6C72_RS12145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E6C72_RS12150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E6C72_RS12155	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E6C72_RS12160	COG0084	hydrolase, TatD family'
E6C72_RS12165	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E6C72_RS12165	COG0321	lipoyl(octanoyl) transferase activity
E6C72_RS12170	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E6C72_RS12200	COG1381	Involved in DNA repair and RecF pathway recombination
E6C72_RS12205	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E6C72_RS12230	COG4786	Flagellar basal body rod
E6C72_RS12235	COG4786	Flagellar basal body rod
E6C72_RS12245	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E6C72_RS12315	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E6C72_RS12325	COG1024	Enoyl-CoA hydratase
E6C72_RS12335	COG0758	DNA mediated transformation
E6C72_RS12340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E6C72_RS12375	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E6C72_RS12390	COG1024	Enoyl-CoA hydratase
E6C72_RS12395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E6C72_RS12415	COG3447	MASE1 domain protein
E6C72_RS12415	COG5001	Diguanylate cyclase
E6C72_RS12415	COG5002	protein histidine kinase activity
E6C72_RS12445	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E6C72_RS12460	COG1238	metal cluster binding
E6C72_RS12465	COG0203	ribosomal protein L17
E6C72_RS12480	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E6C72_RS12495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E6C72_RS12500	COG0251	oxidation-reduction process
E6C72_RS12535	COG0840	transmembrane signaling receptor activity
E6C72_RS12535	COG2972	Histidine kinase
E6C72_RS12565	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E6C72_RS12565	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E6C72_RS12595	COG0154	amidase activity
E6C72_RS12600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E6C72_RS12615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E6C72_RS12625	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E6C72_RS12655	COG0242	peptide deformylase activity
E6C72_RS12660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E6C72_RS12665	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E6C72_RS12670	COG1201	RNA secondary structure unwinding
E6C72_RS12680	COG0415	Belongs to the DNA photolyase family
E6C72_RS12685	COG0735	belongs to the Fur family
E6C72_RS12690	COG0523	cobalamin synthesis protein
E6C72_RS12700	COG0840	transmembrane signaling receptor activity
E6C72_RS12705	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E6C72_RS12720	COG2205	protein histidine kinase activity
E6C72_RS12725	COG2927	DNA polymerase III (CHI subunit)
E6C72_RS12730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E6C72_RS12735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E6C72_RS12735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E6C72_RS12750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E6C72_RS12750	COG0357	Ribosomal RNA small subunit methyltransferase G
E6C72_RS12755	COG4251	negative regulation of phosphorylation
E6C72_RS12760	COG0494	nUDIX hydrolase
E6C72_RS12765	COG0583	DNA-binding transcription factor activity
E6C72_RS12770	COG0497	DNA recombination
E6C72_RS12775	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E6C72_RS12795	COG0006	proline dipeptidase activity
E6C72_RS12805	COG2264	protein methyltransferase activity
E6C72_RS12815	COG0210	DNA helicase
E6C72_RS12820	COG2197	response regulator
E6C72_RS12825	COG2197	response regulator
E6C72_RS12840	COG1749	Flagellar hook protein flgE
E6C72_RS12840	COG1749	Flagellar hook protein flgE
E6C72_RS12855	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E6C72_RS12860	COG0366	Alpha amylase catalytic
E6C72_RS12870	COG0631	protein serine/threonine phosphatase activity
E6C72_RS12875	COG1558	bacterial-type flagellum-dependent cell motility
E6C72_RS12900	COG0859	PFAM glycosyl transferase family 9
E6C72_RS12900	COG0457	Tetratricopeptide repeat
E6C72_RS12915	COG0859	PFAM glycosyl transferase family 9
E6C72_RS12915	COG0457	Tetratricopeptide repeat
E6C72_RS12930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E6C72_RS12960	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
E6C72_RS12965	COG2089	acid synthase
E6C72_RS12985	COG5002	protein histidine kinase activity
E6C72_RS13000	COG0588	phosphoglycerate mutase activity
E6C72_RS13020	COG3693	PFAM glycoside hydrolase, family 10
E6C72_RS13030	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
E6C72_RS13035	COG1045	serine acetyltransferase
E6C72_RS13050	COG3307	-O-antigen
E6C72_RS13055	COG1216	Glycosyl transferase, family 2
E6C72_RS13060	COG0438	transferase activity, transferring glycosyl groups
E6C72_RS13065	COG0438	transferase activity, transferring glycosyl groups
E6C72_RS13080	COG0318	PFAM AMP-dependent synthetase and ligase
E6C72_RS13085	COG0367	asparagine synthase
E6C72_RS13090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E6C72_RS13115	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E6C72_RS13120	COG4208	sulfate ABC transporter
E6C72_RS13130	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E6C72_RS13150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E6C72_RS13180	COG2226	methyltransferase
E6C72_RS13195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C72_RS13205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E6C72_RS13210	COG1846	Transcriptional regulator
E6C72_RS13220	COG3707	response regulator
E6C72_RS13260	COG3833	ABC-type maltose transport systems, permease component
E6C72_RS13265	COG1840	ABC-type Fe3 transport system, periplasmic component
E6C72_RS13280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E6C72_RS13285	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E6C72_RS13290	COG2080	2 iron, 2 sulfur cluster binding
E6C72_RS13295	COG3791	Glutathione-dependent formaldehyde-activating
E6C72_RS13310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C72_RS13315	COG0367	asparagine synthase
E6C72_RS13320	COG1181	Belongs to the D-alanine--D-alanine ligase family
E6C72_RS13320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E6C72_RS13330	COG1363	Peptidase, m42
E6C72_RS13335	COG5002	protein histidine kinase activity
E6C72_RS13335	COG0784	Response regulator, receiver
E6C72_RS13340	COG0745	RESPONSE REGULATOR receiver
E6C72_RS13355	COG0840	transmembrane signaling receptor activity
E6C72_RS13365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E6C72_RS13375	COG2030	dehydratase
E6C72_RS13375	COG1012	belongs to the aldehyde dehydrogenase family
E6C72_RS13390	COG5002	protein histidine kinase activity
E6C72_RS13390	COG2198	Histidine kinase
E6C72_RS13390	COG0784	Response regulator, receiver
E6C72_RS13405	COG1253	flavin adenine dinucleotide binding
E6C72_RS13420	COG2205	protein histidine kinase activity
E6C72_RS13420	COG2198	Histidine kinase
E6C72_RS13420	COG0784	Response regulator, receiver
E6C72_RS13430	COG1396	sequence-specific DNA binding
E6C72_RS13435	COG1766	The M ring may be actively involved in energy transduction
E6C72_RS13445	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C72_RS13450	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E6C72_RS13455	COG2204	response regulator
E6C72_RS13460	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E6C72_RS13540	COG0469	pyruvate kinase activity
E6C72_RS13545	COG0784	Response regulator, receiver
E6C72_RS13545	COG3437	response regulator, receiver
E6C72_RS13550	COG5001	Diguanylate cyclase
E6C72_RS13560	COG1609	Transcriptional regulator
E6C72_RS13565	COG3842	ATPase activity
E6C72_RS13580	COG1177	transmembrane transport
E6C72_RS13585	COG1234	tRNA 3'-trailer cleavage
E6C72_RS13590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E6C72_RS13595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E6C72_RS13600	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E6C72_RS13605	COG0583	DNA-binding transcription factor activity
E6C72_RS13615	COG3842	ATPase activity
E6C72_RS13620	COG1840	ABC-type Fe3 transport system, periplasmic component
E6C72_RS13630	COG1609	Transcriptional regulator
E6C72_RS13640	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C72_RS13645	COG1177	transmembrane transport
E6C72_RS13650	COG3842	ATPase activity
E6C72_RS13655	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E6C72_RS13660	COG1840	ABC-type Fe3 transport system, periplasmic component
E6C72_RS13665	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C72_RS13670	COG0673	inositol 2-dehydrogenase activity
E6C72_RS13680	COG1175	transmembrane transport
E6C72_RS13685	COG0395	ABC-type sugar transport system, permease component
E6C72_RS13720	COG1063	alcohol dehydrogenase
E6C72_RS13725	COG2133	pyrroloquinoline quinone binding
E6C72_RS13755	COG0798	PFAM Bile acid sodium symporter
E6C72_RS13760	COG1012	belongs to the aldehyde dehydrogenase family
E6C72_RS13760	COG1454	alcohol dehydrogenase
E6C72_RS13785	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS13790	COG1129	ABC transporter
E6C72_RS13795	COG3718	enzyme involved in inositol metabolism
E6C72_RS13805	COG1737	Transcriptional regulator
E6C72_RS13825	COG3962	Belongs to the TPP enzyme family
E6C72_RS13830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E6C72_RS13835	COG1082	Xylose isomerase domain protein TIM barrel
E6C72_RS13845	COG0673	inositol 2-dehydrogenase activity
E6C72_RS13850	COG1609	Transcriptional regulator
E6C72_RS13855	COG2814	Major facilitator Superfamily
E6C72_RS13870	COG3300	MHYT domain
E6C72_RS13870	COG5001	Diguanylate cyclase
E6C72_RS13875	COG5383	Protein conserved in bacteria
E6C72_RS13890	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
E6C72_RS13920	COG0601	transmembrane transport
E6C72_RS13930	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E6C72_RS13945	COG0444	Belongs to the ABC transporter superfamily
E6C72_RS13975	COG1446	asparaginase
E6C72_RS13980	COG2362	D-Aminopeptidase
E6C72_RS13990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C72_RS14005	COG0747	negative chemotaxis
E6C72_RS14010	COG4172	Belongs to the ABC transporter superfamily
E6C72_RS14025	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C72_RS14040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C72_RS14045	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E6C72_RS14050	COG1984	allophanate hydrolase subunit 2
E6C72_RS14065	COG0246	Mannitol dehydrogenase
E6C72_RS14070	COG1312	Catalyzes the dehydration of D-mannonate
E6C72_RS14095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E6C72_RS14110	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C72_RS14120	COG0728	peptidoglycan biosynthetic process
E6C72_RS14125	COG0596	Alpha beta hydrolase
E6C72_RS14130	COG0148	phosphopyruvate hydratase activity
E6C72_RS14145	COG0678	peroxiredoxin activity
E6C72_RS14155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C72_RS14165	COG3243	poly(R)-hydroxyalkanoic acid synthase
E6C72_RS14170	COG4991	sh3 domain protein
E6C72_RS14170	COG0515	serine threonine protein kinase
E6C72_RS14170	COG3064	Membrane
E6C72_RS14235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C72_RS14240	COG1309	transcriptional regulator
E6C72_RS14245	COG0840	transmembrane signaling receptor activity
E6C72_RS14255	COG2205	protein histidine kinase activity
E6C72_RS14275	COG4770	biotin carboxylase activity
E6C72_RS14280	COG1024	Enoyl-CoA hydratase
E6C72_RS14285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E6C72_RS14290	COG1960	acyl-CoA dehydrogenase activity
E6C72_RS14295	COG0183	Belongs to the thiolase family
E6C72_RS14300	COG1960	acyl-CoA dehydrogenase activity
E6C72_RS14325	COG3135	benzoate transporter
E6C72_RS14330	COG1802	Transcriptional regulator
E6C72_RS14335	COG2205	protein histidine kinase activity
E6C72_RS14335	COG0784	Response regulator, receiver
E6C72_RS14360	COG4585	Histidine kinase
E6C72_RS14365	COG2197	response regulator
E6C72_RS14400	COG2814	Major facilitator Superfamily
E6C72_RS14425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E6C72_RS14435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C72_RS14450	COG0583	DNA-binding transcription factor activity
E6C72_RS14455	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
E6C72_RS14475	COG3254	rhamnose metabolic process
E6C72_RS14485	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS14490	COG1129	ABC transporter
E6C72_RS14505	COG3347	Dehydrogenase
E6C72_RS14505	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS14510	COG4952	isomerase
E6C72_RS14565	COG2205	protein histidine kinase activity
E6C72_RS14565	COG0784	Response regulator, receiver
E6C72_RS14575	COG3012	SEC-C Motif Domain Protein
E6C72_RS14585	COG1749	Flagellar hook protein flgE
E6C72_RS14585	COG1749	Flagellar hook protein flgE
E6C72_RS14590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E6C72_RS14600	COG2076	Multidrug Resistance protein
E6C72_RS14605	COG1022	Amp-dependent synthetase and ligase
E6C72_RS14605	COG3320	Male sterility
E6C72_RS14615	COG2814	Major facilitator Superfamily
E6C72_RS14625	COG1609	Transcriptional regulator
E6C72_RS14650	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E6C72_RS14655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E6C72_RS14680	COG0671	phosphoesterase, PA-phosphatase related
E6C72_RS14685	COG2204	response regulator
E6C72_RS14690	COG4191	Histidine kinase
E6C72_RS14715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E6C72_RS14765	COG0235	Class ii aldolase
E6C72_RS14775	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E6C72_RS14790	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C72_RS14805	COG3384	dioxygenase
E6C72_RS14815	COG3971	2-oxopent-4-enoate hydratase activity
E6C72_RS14825	COG1846	Transcriptional regulator
E6C72_RS14830	COG1012	belongs to the aldehyde dehydrogenase family
E6C72_RS14845	COG2205	protein histidine kinase activity
E6C72_RS14850	COG0745	RESPONSE REGULATOR receiver
E6C72_RS14860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C72_RS14870	COG0745	RESPONSE REGULATOR receiver
E6C72_RS14875	COG2205	protein histidine kinase activity
E6C72_RS14895	COG1116	anion transmembrane transporter activity
E6C72_RS14920	COG1760	l-serine dehydratase
E6C72_RS14925	COG0814	amino acid
E6C72_RS14930	COG3275	phosphorelay sensor kinase activity
E6C72_RS14935	COG3279	Response regulator of the LytR AlgR family
E6C72_RS14945	COG0583	DNA-binding transcription factor activity
E6C72_RS14950	COG0375	protein maturation
E6C72_RS14955	COG3383	formate dehydrogenase (NAD+) activity
E6C72_RS14960	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E6C72_RS14965	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E6C72_RS14970	COG0651	ATP synthesis coupled electron transport
E6C72_RS14975	COG0650	Formate hydrogenlyase subunit 4
E6C72_RS14980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E6C72_RS14985	COG4237	Hydrogenase 4 membrane
E6C72_RS14990	COG0651	ATP synthesis coupled electron transport
E6C72_RS14995	COG3261	NADH dehydrogenase
E6C72_RS14995	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E6C72_RS15005	COG3260	NADH ubiquinone oxidoreductase 20
E6C72_RS15015	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E6C72_RS15020	COG2116	formate transmembrane transporter activity
E6C72_RS15030	COG0375	protein maturation
E6C72_RS15090	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
E6C72_RS15175	COG4974	Belongs to the 'phage' integrase family
E6C72_RS15185	COG1640	4-alpha-glucanotransferase
E6C72_RS15200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E6C72_RS15205	COG0366	Alpha amylase catalytic
E6C72_RS15225	COG2885	chlorophyll binding
E6C72_RS15225	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E6C72_RS15230	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E6C72_RS15235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E6C72_RS15240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E6C72_RS15245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E6C72_RS15265	COG0515	serine threonine protein kinase
E6C72_RS15265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E6C72_RS15275	COG0583	DNA-binding transcription factor activity
E6C72_RS15280	COG0625	glutathione transferase activity
E6C72_RS15295	COG0411	ABC transporter
E6C72_RS15330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E6C72_RS15335	COG3383	formate dehydrogenase (NAD+) activity
E6C72_RS15350	COG0583	DNA-binding transcription factor activity
E6C72_RS15385	COG0784	Response regulator, receiver
E6C72_RS15385	COG2205	protein histidine kinase activity
E6C72_RS15385	COG5002	protein histidine kinase activity
E6C72_RS15395	COG0747	negative chemotaxis
E6C72_RS15400	COG1475	DNA binding
E6C72_RS15405	COG1192	Involved in chromosome partitioning
E6C72_RS15440	COG2902	Dehydrogenase
E6C72_RS15455	COG2814	Major facilitator Superfamily
E6C72_RS15465	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS15515	COG0667	Aldo Keto reductase
E6C72_RS15525	COG4221	oxidoreductase activity
E6C72_RS15530	COG2814	Major facilitator Superfamily
E6C72_RS15535	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS15565	COG2995	paraquat-inducible protein a
E6C72_RS15585	COG2205	protein histidine kinase activity
E6C72_RS15595	COG2186	Transcriptional regulator
E6C72_RS15600	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS15605	COG4948	Mandelate Racemase Muconate Lactonizing
E6C72_RS15610	COG1063	alcohol dehydrogenase
E6C72_RS15635	COG1120	ATPase activity
E6C72_RS15640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E6C72_RS15645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E6C72_RS15650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E6C72_RS15670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C72_RS15675	COG4172	Belongs to the ABC transporter superfamily
E6C72_RS15690	COG0165	Argininosuccinate lyase
E6C72_RS15710	COG2079	MmgE PrpD family protein
E6C72_RS15715	COG0726	polysaccharide deacetylase
E6C72_RS15725	COG0028	Belongs to the TPP enzyme family
E6C72_RS15735	COG1126	abc transporter atp-binding protein
E6C72_RS15740	COG0765	amino acid transport
E6C72_RS15755	COG0583	DNA-binding transcription factor activity
E6C72_RS15760	COG0842	Transport permease protein
E6C72_RS15765	COG1131	(ABC) transporter
E6C72_RS15770	COG5002	protein histidine kinase activity
E6C72_RS15770	COG5000	phosphorelay sensor kinase activity
E6C72_RS15775	COG0745	RESPONSE REGULATOR receiver
E6C72_RS15790	COG3845	ABC transporter
E6C72_RS15800	COG1079	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS15805	COG4603	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS15840	COG1116	anion transmembrane transporter activity
E6C72_RS15865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E6C72_RS15870	COG4221	oxidoreductase activity
E6C72_RS15880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C72_RS15890	COG4521	taurine ABC transporter
E6C72_RS15895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C72_RS15900	COG0583	DNA-binding transcription factor activity
E6C72_RS15920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E6C72_RS15925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C72_RS15930	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E6C72_RS15950	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E6C72_RS15960	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
E6C72_RS15965	COG2814	Major facilitator Superfamily
E6C72_RS15985	COG4566	intracellular signal transduction
E6C72_RS15990	COG4566	intracellular signal transduction
E6C72_RS16005	COG0583	DNA-binding transcription factor activity
E6C72_RS16010	COG2828	Protein conserved in bacteria
E6C72_RS16020	COG3384	dioxygenase
E6C72_RS16025	COG2159	amidohydrolase
E6C72_RS16040	COG0668	transmembrane transport
E6C72_RS16060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E6C72_RS16075	COG4166	transmembrane transport
E6C72_RS16080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E6C72_RS16085	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E6C72_RS16090	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E6C72_RS16095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C72_RS16125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E6C72_RS16135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E6C72_RS16140	COG1116	anion transmembrane transporter activity
E6C72_RS16145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C72_RS16150	COG0583	DNA-binding transcription factor activity
E6C72_RS16170	COG1116	anion transmembrane transporter activity
E6C72_RS16175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C72_RS16185	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E6C72_RS16225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E6C72_RS16230	COG2188	Transcriptional regulator
E6C72_RS16235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E6C72_RS16335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E6C72_RS16355	COG0582	viral genome integration into host DNA
E6C72_RS16360	COG4396	Host-nuclease inhibitor protein Gam
E6C72_RS16395	COG0740	serine-type endopeptidase activity
E6C72_RS16485	COG0546	phosphoglycolate phosphatase activity
E6C72_RS16525	COG0352	thiamine-phosphate diphosphorylase activity
E6C72_RS16530	COG1802	Transcriptional regulator
E6C72_RS16535	COG0469	pyruvate kinase activity
E6C72_RS16545	COG2084	Dehydrogenase
E6C72_RS16560	COG0517	IMP dehydrogenase activity
E6C72_RS16585	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E6C72_RS16610	COG3195	allantoin biosynthetic process
E6C72_RS16610	COG3648	Uricase
E6C72_RS16620	COG2351	hydroxyisourate hydrolase activity
E6C72_RS16625	COG3960	tartronate-semialdehyde synthase activity
E6C72_RS16635	COG1414	Transcriptional regulator
E6C72_RS16640	COG1802	Transcriptional regulator
E6C72_RS16645	COG0028	Belongs to the TPP enzyme family
E6C72_RS16650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C72_RS16655	COG0045	succinate-CoA ligase (ADP-forming) activity
E6C72_RS16660	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E6C72_RS16665	COG1414	Transcriptional regulator
E6C72_RS16670	COG0604	alcohol dehydrogenase
E6C72_RS16670	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS16670	COG3321	synthase
E6C72_RS16685	COG0860	N-Acetylmuramoyl-L-alanine amidase
E6C72_RS16700	COG0784	Response regulator, receiver
E6C72_RS16720	COG0697	spore germination
E6C72_RS16725	COG0747	negative chemotaxis
E6C72_RS16730	COG0601	transmembrane transport
E6C72_RS16735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C72_RS16740	COG0444	Belongs to the ABC transporter superfamily
E6C72_RS16745	COG4608	Belongs to the ABC transporter superfamily
E6C72_RS16755	COG1666	GTP binding
E6C72_RS16780	COG2890	protein-(glutamine-N5) methyltransferase activity
E6C72_RS16790	COG0142	geranyltranstransferase activity
E6C72_RS16810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E6C72_RS16820	COG2860	membrane
E6C72_RS16830	COG2217	Heavy metal translocating P-type atpase
E6C72_RS16835	COG0789	Transcriptional regulator
E6C72_RS16850	COG2814	Major facilitator Superfamily
E6C72_RS16870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E6C72_RS16880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E6C72_RS16890	COG0402	S-adenosylhomocysteine deaminase activity
E6C72_RS16895	COG1079	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS16900	COG4603	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS16905	COG3845	ABC transporter
E6C72_RS16920	COG1414	Transcriptional regulator
E6C72_RS16925	COG3842	ATPase activity
E6C72_RS16930	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C72_RS16935	COG1177	transmembrane transport
E6C72_RS16950	COG0579	oxidoreductase
E6C72_RS16960	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E6C72_RS16965	COG2223	nitrite transmembrane transporter activity
E6C72_RS16970	COG3546	catalase activity
E6C72_RS16995	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E6C72_RS17000	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E6C72_RS17005	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E6C72_RS17010	COG0295	cytidine deaminase activity
E6C72_RS17015	COG1079	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS17020	COG4603	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS17025	COG3411	Ferredoxin
E6C72_RS17040	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS17080	COG0740	serine-type endopeptidase activity
E6C72_RS17085	COG0463	Glycosyl transferase, family 2
E6C72_RS17100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C72_RS17115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E6C72_RS17135	COG0308	aminopeptidase N
E6C72_RS17160	COG0316	Belongs to the HesB IscA family
E6C72_RS17165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E6C72_RS17180	COG1472	Belongs to the glycosyl hydrolase 3 family
E6C72_RS17185	COG1994	Peptidase M50
E6C72_RS17190	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E6C72_RS17195	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E6C72_RS17200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E6C72_RS17205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E6C72_RS17210	COG0805	protein transport
E6C72_RS17235	COG0420	3'-5' exonuclease activity
E6C72_RS17270	COG0028	Belongs to the TPP enzyme family
E6C72_RS17275	COG0745	RESPONSE REGULATOR receiver
E6C72_RS17285	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E6C72_RS17290	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E6C72_RS17295	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E6C72_RS17310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C72_RS17315	COG2342	PFAM TM1410 hypothetical-related protein
E6C72_RS17350	COG0297	glycogen (starch) synthase activity
E6C72_RS17370	COG3106	COG3106 Predicted ATPase
E6C72_RS17375	COG3768	UPF0283 membrane protein
E6C72_RS17385	COG1741	Belongs to the pirin family
E6C72_RS17390	COG2205	protein histidine kinase activity
E6C72_RS17395	COG0564	pseudouridine synthase activity
E6C72_RS17410	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E6C72_RS17410	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E6C72_RS17430	COG2271	Major facilitator Superfamily
E6C72_RS17435	COG1522	sequence-specific DNA binding
E6C72_RS17480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E6C72_RS17480	COG2169	Transcriptional regulator
E6C72_RS17495	COG1131	(ABC) transporter
E6C72_RS17555	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS17565	COG2273	Hydrolase Family 16
E6C72_RS17570	COG0772	Belongs to the SEDS family
E6C72_RS17575	COG3706	GGDEF domain
E6C72_RS17580	COG1309	transcriptional regulator
E6C72_RS17600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E6C72_RS17605	COG0393	Putative heavy-metal-binding
E6C72_RS17635	COG1280	lysine exporter protein (LysE YggA)
E6C72_RS17640	COG2183	response to ionizing radiation
E6C72_RS17665	COG4251	negative regulation of phosphorylation
E6C72_RS17670	COG0784	Response regulator, receiver
E6C72_RS17680	COG0784	Response regulator, receiver
E6C72_RS17695	COG2847	Copper chaperone PCu(A)C
E6C72_RS17730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C72_RS17735	COG4520	surface antigen
E6C72_RS17765	COG0280	phosphate acetyltransferase
E6C72_RS17765	COG0281	malic enzyme
E6C72_RS17770	COG1301	dicarboxylic acid transport
E6C72_RS17775	COG4191	Histidine kinase
E6C72_RS17780	COG2204	response regulator
E6C72_RS17810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C72_RS17820	COG0765	amino acid transport
E6C72_RS17825	COG1126	abc transporter atp-binding protein
E6C72_RS17830	COG2079	MmgE PrpD family protein
E6C72_RS17835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E6C72_RS17840	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E6C72_RS17870	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E6C72_RS17880	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS17895	COG1012	belongs to the aldehyde dehydrogenase family
E6C72_RS17900	COG0583	DNA-binding transcription factor activity
E6C72_RS17905	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS17915	COG3181	Tripartite tricarboxylate transporter family receptor
E6C72_RS17945	COG1064	alcohol dehydrogenase
E6C72_RS17990	COG0583	DNA-binding transcription factor activity
E6C72_RS17995	COG0583	DNA-binding transcription factor activity
E6C72_RS18000	COG0473	3-isopropylmalate dehydrogenase activity
E6C72_RS18025	COG1320	monovalent cation:proton antiporter activity
E6C72_RS18030	COG2212	antiporter activity
E6C72_RS18035	COG1863	multisubunit Na H antiporter MnhE subunit
E6C72_RS18040	COG0651	ATP synthesis coupled electron transport
E6C72_RS18045	COG1006	Multisubunit Na H antiporter MnhC subunit
E6C72_RS18050	COG2111	Na H antiporter
E6C72_RS18050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E6C72_RS18055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C72_RS18065	COG4191	Histidine kinase
E6C72_RS18070	COG4566	intracellular signal transduction
E6C72_RS18080	COG1760	l-serine dehydratase
E6C72_RS18085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E6C72_RS18095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E6C72_RS18095	COG0446	pyridine nucleotide-disulphide oxidoreductase
E6C72_RS18135	COG4175	Glycine betaine
E6C72_RS18140	COG2113	Glycine betaine
E6C72_RS18160	COG0446	pyridine nucleotide-disulphide oxidoreductase
E6C72_RS18160	COG1902	pentaerythritol trinitrate reductase activity
E6C72_RS18165	COG0247	lactate metabolic process
E6C72_RS18165	COG2181	nitrate reductase activity
E6C72_RS18180	COG4175	Glycine betaine
E6C72_RS18185	COG4176	ABC-type proline glycine betaine transport system permease component
E6C72_RS18205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E6C72_RS18220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E6C72_RS18225	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
E6C72_RS18235	COG0189	ligase activity
E6C72_RS18240	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
E6C72_RS18250	COG0702	epimerase
E6C72_RS18260	COG1029	Formylmethanofuran dehydrogenase, subunit B
E6C72_RS18265	COG1229	Formylmethanofuran dehydrogenase subunit A
E6C72_RS18270	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
E6C72_RS18310	COG1891	lyase activity
E6C72_RS18315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C72_RS18325	COG2807	transmembrane transport
E6C72_RS18330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C72_RS18335	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E6C72_RS18345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C72_RS18350	COG1609	Transcriptional regulator
E6C72_RS18355	COG0583	DNA-binding transcription factor activity
E6C72_RS18360	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS18365	COG3959	Transketolase, thiamine diphosphate binding domain
E6C72_RS18370	COG3958	Transketolase
E6C72_RS18375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C72_RS18385	COG2084	Dehydrogenase
E6C72_RS18395	COG1840	ABC-type Fe3 transport system, periplasmic component
E6C72_RS18410	COG0784	Response regulator, receiver
E6C72_RS18410	COG4191	Histidine kinase
E6C72_RS18425	COG0183	Belongs to the thiolase family
E6C72_RS18430	COG2031	fatty acid transporter
E6C72_RS18435	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E6C72_RS18440	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E6C72_RS18445	COG2204	response regulator
E6C72_RS18450	COG3852	Histidine kinase
E6C72_RS18495	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E6C72_RS18505	COG1737	Transcriptional regulator
E6C72_RS18535	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
E6C72_RS18555	COG1335	isochorismatase
E6C72_RS18560	COG1732	Glycine betaine
E6C72_RS18565	COG1174	glycine betaine transport
E6C72_RS18570	COG1125	glycine betaine transport
E6C72_RS18575	COG1174	glycine betaine transport
E6C72_RS18590	COG3008	intermembrane lipid transfer
E6C72_RS18595	COG2995	paraquat-inducible protein a
E6C72_RS18600	COG2188	Transcriptional regulator
E6C72_RS18610	COG0765	amino acid transport
E6C72_RS18615	COG0765	amino acid transport
E6C72_RS18620	COG1126	abc transporter atp-binding protein
E6C72_RS18625	COG2226	methyltransferase
E6C72_RS18630	COG1122	ATPase activity
E6C72_RS18635	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E6C72_RS18640	COG1268	BioY protein
E6C72_RS18645	COG0318	PFAM AMP-dependent synthetase and ligase
E6C72_RS18665	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E6C72_RS18695	COG0784	Response regulator, receiver
E6C72_RS18695	COG5002	protein histidine kinase activity
E6C72_RS18705	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E6C72_RS18710	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E6C72_RS18730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C72_RS18735	COG0765	amino acid transport
E6C72_RS18740	COG1126	abc transporter atp-binding protein
E6C72_RS18755	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E6C72_RS18765	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E6C72_RS18780	COG0123	including yeast histone deacetylase and acetoin utilization protein
E6C72_RS18795	COG0640	Transcriptional regulator
E6C72_RS18800	COG2363	Small membrane protein
E6C72_RS18845	COG0697	spore germination
E6C72_RS18860	COG0028	Belongs to the TPP enzyme family
E6C72_RS18865	COG1012	belongs to the aldehyde dehydrogenase family
E6C72_RS18890	COG1755	Isoprenylcysteine carboxyl methyltransferase
E6C72_RS18895	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E6C72_RS18915	COG0356	it plays a direct role in the translocation of protons across the membrane
E6C72_RS18925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E6C72_RS18930	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E6C72_RS18935	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E6C72_RS18945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E6C72_RS18950	COG2080	2 iron, 2 sulfur cluster binding
E6C72_RS18960	COG1294	oxidase, subunit
E6C72_RS18965	COG1271	oxidase subunit
E6C72_RS18985	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E6C72_RS18985	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E6C72_RS18990	COG4770	biotin carboxylase activity
E6C72_RS18995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E6C72_RS19005	COG0643	Histidine kinase
E6C72_RS19005	COG2198	Histidine kinase
E6C72_RS19005	COG0784	Response regulator, receiver
E6C72_RS19030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E6C72_RS19035	COG0408	coproporphyrinogen oxidase activity
E6C72_RS19065	COG0435	Glutathione S-transferase
E6C72_RS19070	COG0655	NAD(P)H dehydrogenase (quinone) activity
E6C72_RS19075	COG0583	DNA-binding transcription factor activity
E6C72_RS19100	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS19105	COG0542	response to heat
E6C72_RS19170	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E6C72_RS19210	COG5002	protein histidine kinase activity
E6C72_RS19230	COG2863	cytochrome
E6C72_RS19265	COG1104	cysteine desulfurase activity
E6C72_RS19285	COG1984	allophanate hydrolase subunit 2
E6C72_RS19290	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E6C72_RS19300	COG4336	lyase activity
E6C72_RS19370	COG2986	histidine ammonia-lyase
E6C72_RS19375	COG0402	S-adenosylhomocysteine deaminase activity
E6C72_RS19380	COG1228	amidohydrolase
E6C72_RS19385	COG2188	Transcriptional regulator
E6C72_RS19395	COG2723	6-phospho-beta-galactosidase activity
E6C72_RS19405	COG1196	nuclear chromosome segregation
E6C72_RS19405	COG0739	heme binding
E6C72_RS19405	COG0741	lytic transglycosylase activity
E6C72_RS19420	COG0583	DNA-binding transcription factor activity
E6C72_RS19440	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E6C72_RS19445	COG3842	ATPase activity
E6C72_RS19455	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C72_RS19465	COG1396	sequence-specific DNA binding
E6C72_RS19465	COG1917	Cupin 2, conserved barrel domain protein
E6C72_RS19470	COG1012	belongs to the aldehyde dehydrogenase family
E6C72_RS19480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C72_RS19520	COG0471	metal ion transport
E6C72_RS19520	COG3273	potassium ion transport
E6C72_RS19550	COG2202	Pas domain
E6C72_RS19550	COG2205	protein histidine kinase activity
E6C72_RS19555	COG2373	Large extracellular alpha-helical protein
E6C72_RS19570	COG0183	Belongs to the thiolase family
E6C72_RS19575	COG1024	Enoyl-CoA hydratase
E6C72_RS19575	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C72_RS19580	COG1960	acyl-CoA dehydrogenase activity
E6C72_RS19585	COG2197	response regulator
E6C72_RS19590	COG0517	IMP dehydrogenase activity
E6C72_RS19590	COG0516	GMP reductase activity
E6C72_RS19595	COG3047	cAMP biosynthetic process
E6C72_RS19625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E6C72_RS19630	COG1196	nuclear chromosome segregation
E6C72_RS19640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C72_RS19645	COG0174	glutamine synthetase
E6C72_RS19655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C72_RS19660	COG0765	amino acid transport
E6C72_RS19665	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E6C72_RS19665	COG0546	phosphoglycolate phosphatase activity
E6C72_RS19670	COG2076	Multidrug Resistance protein
E6C72_RS19680	COG3842	ATPase activity
E6C72_RS19685	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C72_RS19690	COG1177	transmembrane transport
E6C72_RS19695	COG3119	arylsulfatase activity
E6C72_RS19720	COG2205	protein histidine kinase activity
E6C72_RS19750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E6C72_RS19750	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E6C72_RS19755	COG0243	molybdopterin cofactor binding
E6C72_RS19760	COG2201	protein-glutamate methylesterase activity
E6C72_RS19770	COG5002	protein histidine kinase activity
E6C72_RS19775	COG2197	response regulator
E6C72_RS19780	COG0827	DNA restriction-modification system
E6C72_RS19785	COG0827	DNA restriction-modification system
E6C72_RS19800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C72_RS19820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E6C72_RS19830	COG2271	Major facilitator Superfamily
E6C72_RS19835	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E6C72_RS19835	COG0674	pyruvate-flavodoxin oxidoreductase activity
E6C72_RS19835	COG1013	pyruvate-flavodoxin oxidoreductase activity
E6C72_RS19840	COG0246	Mannitol dehydrogenase
E6C72_RS19850	COG1609	Transcriptional regulator
E6C72_RS19865	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E6C72_RS19870	COG1882	Formate acetyltransferase
E6C72_RS19875	COG1737	Transcriptional regulator
E6C72_RS19875	COG0837	glucose binding
E6C72_RS19885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E6C72_RS19895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E6C72_RS19900	COG1755	Isoprenylcysteine carboxyl methyltransferase
E6C72_RS19905	COG0800	Aldolase
E6C72_RS19910	COG3734	2-keto-3-deoxy-galactonokinase
E6C72_RS19915	COG1414	Transcriptional regulator
E6C72_RS19935	COG1741	Belongs to the pirin family
E6C72_RS19940	COG0316	Belongs to the HesB IscA family
E6C72_RS19945	COG2151	metal-sulfur cluster biosynthetic enzyme
E6C72_RS19950	COG0822	iron-sulfur transferase activity
E6C72_RS19955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E6C72_RS19960	COG0719	Fe-S assembly protein
E6C72_RS19965	COG0396	ATPase activity
E6C72_RS19970	COG0719	Fe-S assembly protein
E6C72_RS20020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E6C72_RS20025	COG1959	2 iron, 2 sulfur cluster binding
E6C72_RS20030	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS20035	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E6C72_RS20040	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E6C72_RS20060	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E6C72_RS20110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C72_RS20165	COG3459	Glycosyltransferase 36 associated
E6C72_RS20170	COG3239	Fatty acid desaturase
E6C72_RS20250	COG2197	response regulator
E6C72_RS20275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C72_RS20290	COG2814	Major facilitator Superfamily
E6C72_RS20300	COG0583	DNA-binding transcription factor activity
E6C72_RS20305	COG2159	amidohydrolase
E6C72_RS20310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E6C72_RS20325	COG0179	Fumarylacetoacetate (FAA) hydrolase
E6C72_RS20365	COG0625	glutathione transferase activity
E6C72_RS20390	COG0179	Fumarylacetoacetate (FAA) hydrolase
E6C72_RS20395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E6C72_RS20405	COG2188	Transcriptional regulator
E6C72_RS20415	COG2267	carboxylic ester hydrolase activity
E6C72_RS20425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E6C72_RS20430	COG1012	belongs to the aldehyde dehydrogenase family
E6C72_RS20450	COG1177	transmembrane transport
E6C72_RS20455	COG3842	ATPase activity
E6C72_RS20470	COG2912	Transglutaminase-like superfamily
E6C72_RS20485	COG3493	citrate carrier protein
E6C72_RS20495	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E6C72_RS20515	COG3052	prosthetic group binding
E6C72_RS20520	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E6C72_RS20525	COG0281	malic enzyme
E6C72_RS20525	COG0280	phosphate acetyltransferase
E6C72_RS20545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C72_RS20550	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E6C72_RS20555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C72_RS20560	COG1982	Orn Lys Arg decarboxylase major
E6C72_RS20615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E6C72_RS20660	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C72_RS20660	COG1024	Enoyl-CoA hydratase
E6C72_RS20665	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS20675	COG3806	Anti-sigma factor
E6C72_RS20680	COG1595	DNA-templated transcription, initiation
E6C72_RS20690	COG1024	Enoyl-CoA hydratase
E6C72_RS20700	COG4176	ABC-type proline glycine betaine transport system permease component
E6C72_RS20705	COG1309	transcriptional regulator
E6C72_RS20720	COG0747	negative chemotaxis
E6C72_RS20725	COG0784	Response regulator, receiver
E6C72_RS20725	COG3437	response regulator, receiver
E6C72_RS20730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E6C72_RS20755	COG0737	Belongs to the 5'-nucleotidase family
E6C72_RS20760	COG0505	Belongs to the CarA family
E6C72_RS20765	COG2068	MobA-Related Protein
E6C72_RS20770	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E6C72_RS20805	COG2358	TRAP transporter, solute receptor (TAXI family
E6C72_RS20845	COG3437	response regulator, receiver
E6C72_RS20850	COG3012	SEC-C Motif Domain Protein
E6C72_RS20860	COG1448	Aminotransferase
E6C72_RS20870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E6C72_RS20875	COG0583	DNA-binding transcription factor activity
E6C72_RS20885	COG3483	tryptophan 2,3-dioxygenase activity
E6C72_RS20905	COG1845	cytochrome c oxidase, subunit III
E6C72_RS20915	COG3256	nitric oxide reductase
E6C72_RS20920	COG0714	Associated with various cellular activities
E6C72_RS20930	COG0521	Mo-molybdopterin cofactor biosynthetic process
E6C72_RS20940	COG4221	oxidoreductase activity
E6C72_RS20945	COG1755	Isoprenylcysteine carboxyl methyltransferase
E6C72_RS20950	COG3424	synthase
E6C72_RS20960	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E6C72_RS20965	COG2272	Belongs to the type-B carboxylesterase lipase family
E6C72_RS20980	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E6C72_RS20990	COG2204	response regulator
E6C72_RS20995	COG0375	protein maturation
E6C72_RS21050	COG1566	PFAM secretion protein HlyD family protein
E6C72_RS21065	COG3956	TIGRFAM MazG family protein
E6C72_RS21110	COG3180	Ammonia monooxygenase
E6C72_RS21125	COG2132	Multicopper oxidase
E6C72_RS21145	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E6C72_RS21150	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E6C72_RS21155	COG0583	DNA-binding transcription factor activity
E6C72_RS21165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E6C72_RS21165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E6C72_RS21170	COG1105	Belongs to the carbohydrate kinase PfkB family
E6C72_RS21175	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C72_RS21175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C72_RS21180	COG1609	Transcriptional regulator
E6C72_RS21200	COG0489	protein tyrosine kinase activity
E6C72_RS21200	COG3206	protein involved in exopolysaccharide biosynthesis
E6C72_RS21220	COG0438	transferase activity, transferring glycosyl groups
E6C72_RS21235	COG0438	transferase activity, transferring glycosyl groups
E6C72_RS21270	COG2116	formate transmembrane transporter activity
E6C72_RS21275	COG2815	serine threonine protein kinase
E6C72_RS21275	COG0515	serine threonine protein kinase
E6C72_RS21285	COG1131	(ABC) transporter
E6C72_RS21300	COG0366	Alpha amylase catalytic
E6C72_RS21310	COG0066	3-isopropylmalate dehydratase activity
E6C72_RS21315	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E6C72_RS21320	COG1053	succinate dehydrogenase
E6C72_RS21325	COG1335	isochorismatase
E6C72_RS21370	COG2188	Transcriptional regulator
E6C72_RS21375	COG0668	transmembrane transport
E6C72_RS21395	COG0583	DNA-binding transcription factor activity
E6C72_RS21400	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS21415	COG1064	alcohol dehydrogenase
E6C72_RS21435	COG0459	protein refolding
E6C72_RS21440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E6C72_RS21455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C72_RS21460	COG1116	anion transmembrane transporter activity
E6C72_RS21490	COG1464	Belongs to the NlpA lipoprotein family
E6C72_RS21495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E6C72_RS21500	COG2011	ABC-type metal ion transport system permease component
E6C72_RS21510	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E6C72_RS21515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C72_RS21520	COG1116	anion transmembrane transporter activity
E6C72_RS21535	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E6C72_RS21555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C72_RS21560	COG4597	amino acid ABC transporter
E6C72_RS21565	COG0765	amino acid transport
E6C72_RS21570	COG1396	sequence-specific DNA binding
E6C72_RS21580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C72_RS21585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E6C72_RS21595	COG1116	anion transmembrane transporter activity
E6C72_RS21605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E6C72_RS21615	COG3220	belongs to the UPF0276 family
E6C72_RS21635	COG5001	Diguanylate cyclase
E6C72_RS21640	COG0534	Mate efflux family protein
E6C72_RS21645	COG2205	protein histidine kinase activity
E6C72_RS21650	COG0745	RESPONSE REGULATOR receiver
E6C72_RS21655	COG1538	Outer membrane efflux protein
E6C72_RS21665	COG1136	(ABC) transporter
E6C72_RS21690	COG1192	Involved in chromosome partitioning
E6C72_RS21695	COG1475	DNA binding
E6C72_RS21700	COG3005	denitrification pathway
E6C72_RS21715	COG3062	negative regulation of establishment of protein localization
E6C72_RS21725	COG4459	periplasmic nitrate reductase
E6C72_RS21735	COG4263	nitrous-oxide reductase activity
E6C72_RS21750	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E6C72_RS21760	COG1477	protein flavinylation
E6C72_RS21765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E6C72_RS21795	COG0826	peptidase U32
E6C72_RS21810	COG1802	Transcriptional regulator
E6C72_RS21820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C72_RS21825	COG1116	anion transmembrane transporter activity
E6C72_RS21830	COG0402	S-adenosylhomocysteine deaminase activity
E6C72_RS21845	COG1802	Transcriptional regulator
E6C72_RS21850	COG0154	amidase activity
E6C72_RS21865	COG1177	transmembrane transport
E6C72_RS21875	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E6C72_RS21880	COG3842	ATPase activity
E6C72_RS21885	COG0154	amidase activity
E6C72_RS21890	COG1802	Transcriptional regulator
E6C72_RS21895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C72_RS21915	COG0318	PFAM AMP-dependent synthetase and ligase
E6C72_RS21930	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS21960	COG0400	carboxylic ester hydrolase activity
E6C72_RS21965	COG0435	Glutathione S-transferase
E6C72_RS21970	COG2353	YceI-like domain
E6C72_RS21990	COG1609	Transcriptional regulator
E6C72_RS21995	COG1070	Carbohydrate kinase
E6C72_RS22000	COG2115	Belongs to the xylose isomerase family
E6C72_RS22005	COG4213	ABC transporter substrate-binding protein
E6C72_RS22010	COG4214	carbohydrate transport
E6C72_RS22015	COG1129	ABC transporter
E6C72_RS22025	COG4916	TIR domain
E6C72_RS22045	COG4626	Terminase
E6C72_RS22045	COG1802	Transcriptional regulator
E6C72_RS22060	COG4191	Histidine kinase
E6C72_RS22065	COG4566	intracellular signal transduction
E6C72_RS22070	COG4566	intracellular signal transduction
E6C72_RS22075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C72_RS22080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E6C72_RS22095	COG1309	transcriptional regulator
E6C72_RS22110	COG0673	inositol 2-dehydrogenase activity
E6C72_RS22120	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E6C72_RS22130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C72_RS22135	COG1177	transmembrane transport
E6C72_RS22185	COG0251	oxidation-reduction process
E6C72_RS22190	COG0251	oxidation-reduction process
E6C72_RS22205	COG1850	ribulose-bisphosphate carboxylase activity
E6C72_RS22215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C72_RS22220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C72_RS22225	COG1609	Transcriptional regulator
E6C72_RS22245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C72_RS22275	COG2233	PERMEase
E6C72_RS22290	COG1069	ribulokinase activity
E6C72_RS22295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E6C72_RS22305	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS22310	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS22315	COG1129	ABC transporter
E6C72_RS22320	COG1879	ABC-type sugar transport system periplasmic component
E6C72_RS22325	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E6C72_RS22330	COG1349	DNA-binding transcription factor activity
E6C72_RS22340	COG3383	formate dehydrogenase (NAD+) activity
E6C72_RS22380	COG1131	(ABC) transporter
E6C72_RS22385	COG0189	ligase activity
E6C72_RS22385	COG0569	domain protein
E6C72_RS22400	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
E6C72_RS22425	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
E6C72_RS22430	COG1229	Formylmethanofuran dehydrogenase subunit A
E6C72_RS22435	COG1029	Formylmethanofuran dehydrogenase, subunit B
E6C72_RS22445	COG0702	epimerase
E6C72_RS22450	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
E6C72_RS22495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E6C72_RS22500	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E6C72_RS22535	COG0437	4 iron, 4 sulfur cluster binding
E6C72_RS22600	COG2186	Transcriptional regulator
E6C72_RS22605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E6C72_RS22610	COG2271	Major facilitator Superfamily
E6C72_RS22615	COG1312	Catalyzes the dehydration of D-mannonate
E6C72_RS22630	COG2721	sulfolactate sulfo-lyase activity
E6C72_RS22635	COG2706	6-phosphogluconolactonase activity
E6C72_RS22640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E6C72_RS22640	COG2010	Cytochrome c
E6C72_RS22645	COG2080	2 iron, 2 sulfur cluster binding
E6C72_RS22650	COG1846	Transcriptional regulator
E6C72_RS22655	COG2309	aminopeptidase activity
E6C72_RS22660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E6C72_RS22665	COG0596	Alpha beta hydrolase
E6C72_RS22670	COG3473	Maleate cis-trans isomerase
E6C72_RS22675	COG1335	isochorismatase
E6C72_RS22680	COG2271	Major facilitator Superfamily
E6C72_RS22700	COG1522	sequence-specific DNA binding
E6C72_RS22725	COG2855	membrane
E6C72_RS22740	COG0657	acetylesterase activity
E6C72_RS22755	COG0583	DNA-binding transcription factor activity
E6C72_RS22765	COG1522	sequence-specific DNA binding
E6C72_RS22770	COG4172	Belongs to the ABC transporter superfamily
E6C72_RS22775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C72_RS22780	COG0601	transmembrane transport
E6C72_RS22800	COG0454	-acetyltransferase
E6C72_RS22810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C72_RS22825	COG1012	belongs to the aldehyde dehydrogenase family
E6C72_RS22835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E6C72_RS22855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C72_RS22880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E6C72_RS22885	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E6C72_RS22890	COG1802	Transcriptional regulator
E6C72_RS22895	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C72_RS22920	COG1175	transmembrane transport
E6C72_RS22930	COG3842	ATPase activity
E6C72_RS22940	COG4154	Belongs to the RbsD FucU family
E6C72_RS22950	COG2721	sulfolactate sulfo-lyase activity
E6C72_RS22965	COG1879	ABC-type sugar transport system periplasmic component
E6C72_RS22970	COG4214	carbohydrate transport
E6C72_RS22975	COG1129	ABC transporter
E6C72_RS22980	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS23035	COG1136	(ABC) transporter
E6C72_RS23035	COG0577	efflux transmembrane transporter activity
E6C72_RS23115	COG3002	Belongs to the UPF0753 family
E6C72_RS23120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E6C72_RS23150	COG1132	(ABC) transporter
E6C72_RS23165	COG0641	radical SAM
E6C72_RS23195	COG3321	synthase
E6C72_RS23195	COG0604	alcohol dehydrogenase
E6C72_RS23200	COG2070	2-Nitropropane dioxygenase
E6C72_RS23200	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E6C72_RS23235	COG0251	oxidation-reduction process
E6C72_RS23280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E6C72_RS23290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C72_RS23325	COG3273	potassium ion transport
E6C72_RS23325	COG0471	metal ion transport
E6C72_RS23330	COG0517	IMP dehydrogenase activity
E6C72_RS23345	COG0784	Response regulator, receiver
E6C72_RS23345	COG2205	protein histidine kinase activity
E6C72_RS23350	COG3023	N-Acetylmuramoyl-L-alanine amidase
E6C72_RS23390	COG1914	H( )-stimulated, divalent metal cation uptake system
E6C72_RS23395	COG1321	iron dependent repressor
E6C72_RS23405	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E6C72_RS23405	COG1918	ferrous iron import across plasma membrane
E6C72_RS23415	COG2814	Major facilitator Superfamily
E6C72_RS23420	COG0596	Alpha beta hydrolase
E6C72_RS23420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E6C72_RS23435	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E6C72_RS23455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E6C72_RS23460	COG0375	protein maturation
E6C72_RS23465	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E6C72_RS23465	COG0493	'glutamate synthase
E6C72_RS23470	COG2414	aldehyde ferredoxin oxidoreductase
E6C72_RS23480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E6C72_RS23480	COG2111	Na H antiporter
E6C72_RS23485	COG0651	ATP synthesis coupled electron transport
E6C72_RS23490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E6C72_RS23495	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E6C72_RS23505	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E6C72_RS23510	COG0649	NAD binding
E6C72_RS23555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E6C72_RS23600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C72_RS23605	COG0348	domain, Protein
E6C72_RS23660	COG0010	Belongs to the arginase family
E6C72_RS23670	COG0025	NhaP-type Na H and K H
E6C72_RS23685	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E6C72_RS23695	COG1335	isochorismatase
E6C72_RS23705	COG0673	inositol 2-dehydrogenase activity
E6C72_RS23715	COG1879	ABC-type sugar transport system periplasmic component
E6C72_RS23720	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS23725	COG1129	ABC transporter
E6C72_RS23735	COG0840	transmembrane signaling receptor activity
E6C72_RS23755	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C72_RS23755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C72_RS23765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E6C72_RS23770	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E6C72_RS23775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E6C72_RS23780	COG2188	Transcriptional regulator
E6C72_RS23785	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E6C72_RS23790	COG2190	(PTS) system
E6C72_RS23790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E6C72_RS23790	COG1263	PTS System
E6C72_RS23795	COG0840	transmembrane signaling receptor activity
E6C72_RS23805	COG3842	ATPase activity
E6C72_RS23815	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C72_RS23820	COG0395	ABC-type sugar transport system, permease component
E6C72_RS23845	COG4191	Histidine kinase
E6C72_RS23850	COG1301	dicarboxylic acid transport
E6C72_RS23855	COG1027	Aspartate ammonia-lyase
E6C72_RS23860	COG2258	MOSC domain
E6C72_RS23875	COG0604	alcohol dehydrogenase
E6C72_RS23890	COG2205	protein histidine kinase activity
E6C72_RS23890	COG0784	Response regulator, receiver
E6C72_RS23895	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E6C72_RS23905	COG0583	DNA-binding transcription factor activity
E6C72_RS23910	COG0667	Aldo Keto reductase
E6C72_RS23915	COG2223	nitrite transmembrane transporter activity
E6C72_RS23925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C72_RS23935	COG4191	Histidine kinase
E6C72_RS23955	COG0346	lactoylglutathione lyase activity
E6C72_RS23960	COG3474	cytochrome
E6C72_RS23970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E6C72_RS23985	COG0459	protein refolding
E6C72_RS24015	COG0154	amidase activity
E6C72_RS24040	COG3119	arylsulfatase activity
E6C72_RS24050	COG0038	chloride channel
E6C72_RS24065	COG0765	amino acid transport
E6C72_RS24080	COG1802	Transcriptional regulator
E6C72_RS24085	COG0405	Gamma-glutamyltransferase
E6C72_RS24100	COG3842	ATPase activity
E6C72_RS24125	COG4615	Cyclic peptide transporter
E6C72_RS24135	COG0367	asparagine synthase
E6C72_RS24190	COG2186	Transcriptional regulator
E6C72_RS24195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C72_RS24200	COG0765	amino acid transport
E6C72_RS24205	COG1126	abc transporter atp-binding protein
E6C72_RS24215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E6C72_RS24230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E6C72_RS24235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E6C72_RS24240	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E6C72_RS24245	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C72_RS24250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C72_RS24255	COG1309	transcriptional regulator
E6C72_RS24305	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS24325	COG0022	dehydrogenase e1 component
E6C72_RS24330	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E6C72_RS24335	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS24355	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E6C72_RS24360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C72_RS24410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E6C72_RS24410	COG1116	anion transmembrane transporter activity
E6C72_RS24415	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS24425	COG0179	Fumarylacetoacetate (FAA) hydrolase
E6C72_RS24430	COG1802	Transcriptional regulator
E6C72_RS24440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E6C72_RS24440	COG1213	nucleotidyl transferase
E6C72_RS24450	COG4589	Belongs to the CDS family
E6C72_RS24455	COG0501	Belongs to the peptidase M48B family
E6C72_RS24470	COG4221	oxidoreductase activity
E6C72_RS24490	COG1301	dicarboxylic acid transport
E6C72_RS24495	COG2828	Protein conserved in bacteria
E6C72_RS24500	COG0583	DNA-binding transcription factor activity
E6C72_RS24510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E6C72_RS24510	COG1017	nitric oxide dioxygenase activity
E6C72_RS24515	COG0625	glutathione transferase activity
E6C72_RS24525	COG1869	D-ribose catabolic process
E6C72_RS24530	COG1129	ABC transporter
E6C72_RS24535	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS24540	COG1879	ABC-type sugar transport system periplasmic component
E6C72_RS24545	COG1609	Transcriptional regulator
E6C72_RS24550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E6C72_RS24555	COG0659	secondary active sulfate transmembrane transporter activity
E6C72_RS24565	COG1473	amidohydrolase
E6C72_RS24570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C72_RS24585	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS24620	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS24625	COG0583	DNA-binding transcription factor activity
E6C72_RS24640	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS24645	COG1309	transcriptional regulator
E6C72_RS24650	COG2226	methyltransferase
E6C72_RS24655	COG2814	Major facilitator Superfamily
E6C72_RS24660	COG0583	DNA-binding transcription factor activity
E6C72_RS24665	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E6C72_RS24670	COG2186	Transcriptional regulator
E6C72_RS24680	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E6C72_RS24685	COG1454	alcohol dehydrogenase
E6C72_RS24690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E6C72_RS24715	COG4221	oxidoreductase activity
E6C72_RS24725	COG0697	spore germination
E6C72_RS24730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C72_RS24740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E6C72_RS24745	COG0235	Class ii aldolase
E6C72_RS24755	COG0601	transmembrane transport
E6C72_RS24760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C72_RS24770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E6C72_RS24790	COG0604	alcohol dehydrogenase
E6C72_RS24790	COG3321	synthase
E6C72_RS24815	COG3052	prosthetic group binding
E6C72_RS24835	COG1802	Transcriptional regulator
E6C72_RS24840	COG5001	Diguanylate cyclase
E6C72_RS24845	COG2116	formate transmembrane transporter activity
E6C72_RS24850	COG0148	phosphopyruvate hydratase activity
E6C72_RS24860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E6C72_RS24870	COG0126	phosphoglycerate kinase activity
E6C72_RS24905	COG0252	asparaginase activity
E6C72_RS24925	COG0840	transmembrane signaling receptor activity
E6C72_RS24925	COG3290	protein histidine kinase activity
E6C72_RS24930	COG4566	intracellular signal transduction
E6C72_RS24940	COG2815	serine threonine protein kinase
E6C72_RS24940	COG0515	serine threonine protein kinase
E6C72_RS24945	COG4977	sequence-specific DNA binding
E6C72_RS24960	COG3842	ATPase activity
E6C72_RS24965	COG0395	ABC-type sugar transport system, permease component
E6C72_RS24970	COG1175	transmembrane transport
E6C72_RS24980	COG1609	Transcriptional regulator
E6C72_RS25005	COG2814	Major facilitator Superfamily
E6C72_RS25015	COG1024	Enoyl-CoA hydratase
E6C72_RS25020	COG1012	belongs to the aldehyde dehydrogenase family
E6C72_RS25025	COG2203	Gaf domain
E6C72_RS25025	COG0840	transmembrane signaling receptor activity
E6C72_RS25035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E6C72_RS25050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C72_RS25065	COG1012	belongs to the aldehyde dehydrogenase family
E6C72_RS25075	COG2814	Major facilitator Superfamily
E6C72_RS25090	COG2188	Transcriptional regulator
E6C72_RS25105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E6C72_RS25120	COG0431	NADPH-dependent FMN reductase
E6C72_RS25130	COG0411	ABC transporter
E6C72_RS25150	COG0410	ABC transporter
E6C72_RS25160	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E6C72_RS25185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E6C72_RS25185	COG0438	transferase activity, transferring glycosyl groups
E6C72_RS25220	COG0463	Glycosyl transferase, family 2
E6C72_RS25235	COG3206	protein involved in exopolysaccharide biosynthesis
E6C72_RS25235	COG0489	protein tyrosine kinase activity
E6C72_RS25240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E6C72_RS25245	COG0438	transferase activity, transferring glycosyl groups
E6C72_RS25250	COG0438	transferase activity, transferring glycosyl groups
E6C72_RS25300	COG0242	peptide deformylase activity
E6C72_RS25330	COG4638	Rieske (2fe-2S)
E6C72_RS25335	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E6C72_RS25340	COG2146	nitrite reductase [NAD(P)H] activity
E6C72_RS25360	COG1079	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS25365	COG1137	ATPase activity
E6C72_RS25375	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS25400	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS25405	COG1879	ABC-type sugar transport system periplasmic component
E6C72_RS25455	COG0564	pseudouridine synthase activity
E6C72_RS25465	COG0454	-acetyltransferase
E6C72_RS25470	COG1280	lysine exporter protein (LysE YggA)
E6C72_RS25505	COG2814	Major facilitator Superfamily
E6C72_RS25515	COG0667	Aldo Keto reductase
E6C72_RS25520	COG1902	pentaerythritol trinitrate reductase activity
E6C72_RS25530	COG1192	Involved in chromosome partitioning
E6C72_RS25545	COG1960	acyl-CoA dehydrogenase activity
E6C72_RS25575	COG3210	domain, Protein
E6C72_RS25580	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E6C72_RS25605	COG0601	transmembrane transport
E6C72_RS25610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C72_RS25625	COG0438	transferase activity, transferring glycosyl groups
E6C72_RS25630	COG0588	phosphoglycerate mutase activity
E6C72_RS25650	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
E6C72_RS25665	COG1126	abc transporter atp-binding protein
E6C72_RS25670	COG0765	amino acid transport
E6C72_RS25675	COG0765	amino acid transport
E6C72_RS25680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C72_RS25720	COG0667	Aldo Keto reductase
E6C72_RS25725	COG2814	Major facilitator Superfamily
E6C72_RS25735	COG0583	DNA-binding transcription factor activity
E6C72_RS25750	COG0626	cystathionine gamma-synthase activity
E6C72_RS25760	COG0583	DNA-binding transcription factor activity
E6C72_RS25800	COG0318	PFAM AMP-dependent synthetase and ligase
E6C72_RS25800	COG0204	Acyl-transferase
E6C72_RS25805	COG2884	Cell division ATP-binding protein ftsE
E6C72_RS25825	COG2217	Heavy metal translocating P-type atpase
E6C72_RS25830	COG2610	gluconate transmembrane transporter activity
E6C72_RS25835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E6C72_RS25840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E6C72_RS25845	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS25880	COG1672	PFAM Archaeal ATPase
E6C72_RS25880	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E6C72_RS25885	COG0129	dihydroxy-acid dehydratase activity
E6C72_RS25895	COG1566	PFAM secretion protein HlyD family protein
E6C72_RS25950	COG0564	pseudouridine synthase activity
E6C72_RS25960	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E6C72_RS25970	COG0842	Transport permease protein
E6C72_RS25975	COG0842	Transport permease protein
E6C72_RS25975	COG1129	ABC transporter
E6C72_RS25980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C72_RS25985	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E6C72_RS25990	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E6C72_RS25995	COG1609	Transcriptional regulator
E6C72_RS26000	COG3265	gluconokinase activity
E6C72_RS26010	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C72_RS26015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C72_RS26020	COG0840	transmembrane signaling receptor activity
E6C72_RS26025	COG3485	protocatechuate 3,4-dioxygenase
E6C72_RS26030	COG3485	protocatechuate 3,4-dioxygenase
E6C72_RS26040	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E6C72_RS26045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E6C72_RS26050	COG0183	Belongs to the thiolase family
E6C72_RS26055	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E6C72_RS26060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E6C72_RS26065	COG0683	leucine binding
E6C72_RS26095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C72_RS26110	COG1126	abc transporter atp-binding protein
E6C72_RS26115	COG0765	amino acid transport
E6C72_RS26120	COG4597	amino acid ABC transporter
E6C72_RS26125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C72_RS26140	COG2814	Major facilitator Superfamily
E6C72_RS26155	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E6C72_RS26170	COG3634	alkyl hydroperoxide reductase activity
E6C72_RS26180	COG0583	DNA-binding transcription factor activity
E6C72_RS26185	COG0287	Prephenate dehydrogenase
E6C72_RS26195	COG0693	protein deglycase activity
E6C72_RS26200	COG2224	Isocitrate lyase
E6C72_RS26205	COG3800	Transcriptional regulator
E6C72_RS26205	COG1396	sequence-specific DNA binding
E6C72_RS26230	COG0306	phosphate transporter
E6C72_RS26240	COG2205	protein histidine kinase activity
E6C72_RS26275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C72_RS26280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C72_RS26285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C72_RS26290	COG4774	siderophore transport
E6C72_RS26315	COG0668	transmembrane transport
E6C72_RS26325	COG1181	Belongs to the D-alanine--D-alanine ligase family
E6C72_RS26325	COG2918	glutathione biosynthetic process
E6C72_RS26335	COG1960	acyl-CoA dehydrogenase activity
E6C72_RS26340	COG0840	transmembrane signaling receptor activity
E6C72_RS26375	COG0686	Belongs to the AlaDH PNT family
E6C72_RS26380	COG1522	sequence-specific DNA binding
E6C72_RS26385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E6C72_RS26390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E6C72_RS26400	COG0784	Response regulator, receiver
E6C72_RS26400	COG2198	Histidine kinase
E6C72_RS26400	COG2205	protein histidine kinase activity
E6C72_RS26420	COG1280	lysine exporter protein (LysE YggA)
E6C72_RS26425	COG3437	response regulator, receiver
E6C72_RS26425	COG0784	Response regulator, receiver
E6C72_RS26430	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E6C72_RS26440	COG1121	(ABC) transporter
E6C72_RS26445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E6C72_RS26455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E6C72_RS26465	COG0347	Belongs to the P(II) protein family
E6C72_RS26470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E6C72_RS26515	COG1045	serine acetyltransferase
E6C72_RS26550	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E6C72_RS26600	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E6C72_RS26605	COG1530	ribonuclease E activity
E6C72_RS26635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E6C72_RS26645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E6C72_RS26665	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E6C72_RS26670	COG2011	ABC-type metal ion transport system permease component
E6C72_RS26675	COG1464	Belongs to the NlpA lipoprotein family
E6C72_RS26680	COG0457	Tetratricopeptide repeat
E6C72_RS26680	COG0859	PFAM glycosyl transferase family 9
E6C72_RS26685	COG2201	protein-glutamate methylesterase activity
E6C72_RS26690	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C72_RS26690	COG1776	CheC inhibitor of MCP methylation
E6C72_RS26695	COG0840	transmembrane signaling receptor activity
E6C72_RS26700	COG0835	chemotaxis
E6C72_RS26705	COG2201	protein-glutamate methylesterase activity
E6C72_RS26715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E6C72_RS26725	COG0643	Histidine kinase
E6C72_RS26725	COG2198	Histidine kinase
E6C72_RS26735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C72_RS26740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C72_RS26745	COG1309	transcriptional regulator
E6C72_RS26755	COG0402	S-adenosylhomocysteine deaminase activity
E6C72_RS26760	COG1971	Probably functions as a manganese efflux pump
E6C72_RS26765	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E6C72_RS26775	COG1131	(ABC) transporter
E6C72_RS26785	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E6C72_RS26800	COG3206	protein involved in exopolysaccharide biosynthesis
E6C72_RS26800	COG0489	protein tyrosine kinase activity
E6C72_RS26810	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E6C72_RS26815	COG1088	dTDP-glucose 4,6-dehydratase activity
E6C72_RS26820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C72_RS26835	COG0438	transferase activity, transferring glycosyl groups
E6C72_RS26840	COG1522	sequence-specific DNA binding
E6C72_RS26870	COG0784	Response regulator, receiver
E6C72_RS26880	COG3214	Protein conserved in bacteria
E6C72_RS26890	COG4608	Belongs to the ABC transporter superfamily
E6C72_RS26925	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E6C72_RS26930	COG0583	DNA-binding transcription factor activity
E6C72_RS26940	COG3845	ABC transporter
E6C72_RS26945	COG1744	ABC transporter substrate-binding protein PnrA-like
E6C72_RS26980	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS27045	COG2099	Precorrin-6x reductase
E6C72_RS27075	COG1797	cobyrinic acid a,c-diamide synthase activity
E6C72_RS27080	COG0778	Nitroreductase
E6C72_RS27085	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS27090	COG1129	ABC transporter
E6C72_RS27095	COG1879	ABC-type sugar transport system periplasmic component
E6C72_RS27100	COG1984	allophanate hydrolase subunit 2
E6C72_RS27110	COG0439	Biotin carboxylase
E6C72_RS27115	COG0511	ligase activity, forming carbon-carbon bonds
E6C72_RS27120	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E6C72_RS27180	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E6C72_RS27190	COG3012	SEC-C Motif Domain Protein
E6C72_RS27195	COG1278	Cold shock
E6C72_RS27200	COG1522	sequence-specific DNA binding
E6C72_RS27205	COG0586	Pfam SNARE associated Golgi protein
E6C72_RS27220	COG0427	acetyl-CoA hydrolase
E6C72_RS27240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E6C72_RS27245	COG2205	protein histidine kinase activity
E6C72_RS27245	COG2202	Pas domain
E6C72_RS27260	COG1012	belongs to the aldehyde dehydrogenase family
E6C72_RS27265	COG2864	formate dehydrogenase
E6C72_RS27270	COG0437	4 iron, 4 sulfur cluster binding
E6C72_RS27275	COG3383	formate dehydrogenase (NAD+) activity
E6C72_RS27275	COG0243	molybdopterin cofactor binding
E6C72_RS27300	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E6C72_RS27320	COG4948	Mandelate Racemase Muconate Lactonizing
E6C72_RS27325	COG0583	DNA-binding transcription factor activity
E6C72_RS27350	COG0745	RESPONSE REGULATOR receiver
E6C72_RS27355	COG1278	Cold shock
E6C72_RS27380	COG0745	RESPONSE REGULATOR receiver
E6C72_RS27385	COG0835	chemotaxis
E6C72_RS27390	COG0784	Response regulator, receiver
E6C72_RS27390	COG2198	Histidine kinase
E6C72_RS27390	COG0643	Histidine kinase
E6C72_RS27405	COG2205	protein histidine kinase activity
E6C72_RS27420	COG3920	Histidine kinase
E6C72_RS27430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E6C72_RS27445	COG0531	amino acid
E6C72_RS27455	COG4303	Ethanolamine ammonia lyase large subunit
E6C72_RS27475	COG1280	lysine exporter protein (LysE YggA)
E6C72_RS27490	COG2233	PERMEase
E6C72_RS27500	COG2723	6-phospho-beta-galactosidase activity
E6C72_RS27520	COG1295	ribonuclease BN
E6C72_RS27560	COG0793	Belongs to the peptidase S41A family
E6C72_RS27565	COG0736	holo-[acyl-carrier-protein] synthase activity
E6C72_RS27570	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E6C72_RS27575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E6C72_RS27580	COG0671	phosphoesterase, PA-phosphatase related
E6C72_RS27600	COG0848	biopolymer transport protein
E6C72_RS27615	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS27630	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E6C72_RS27645	COG1595	DNA-templated transcription, initiation
E6C72_RS27650	COG3806	Anti-sigma factor
E6C72_RS27695	COG0405	Gamma-glutamyltransferase
E6C72_RS27745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E6C72_RS27765	COG1764	response to oxidative stress
E6C72_RS27785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C72_RS27790	COG3396	Phenylacetate-CoA oxygenase
E6C72_RS27795	COG3460	Phenylacetate-CoA oxygenase
E6C72_RS27800	COG3396	Phenylacetate-CoA oxygenase
E6C72_RS27805	COG2151	metal-sulfur cluster biosynthetic enzyme
E6C72_RS27810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E6C72_RS27820	COG1024	Enoyl-CoA hydratase
E6C72_RS27825	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C72_RS27830	COG2050	protein possibly involved in aromatic compounds catabolism
E6C72_RS27835	COG0183	Belongs to the thiolase family
E6C72_RS27855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C72_RS27860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C72_RS27870	COG1802	Transcriptional regulator
E6C72_RS27875	COG1803	Methylglyoxal synthase
E6C72_RS27880	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
E6C72_RS27885	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS27890	COG1917	Cupin 2, conserved barrel domain protein
E6C72_RS27895	COG1802	Transcriptional regulator
E6C72_RS27900	COG1904	glucuronate isomerase
E6C72_RS27905	COG2721	sulfolactate sulfo-lyase activity
E6C72_RS27915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E6C72_RS27920	COG1309	transcriptional regulator
E6C72_RS27925	COG1028	Short-chain dehydrogenase reductase Sdr
E6C72_RS27955	COG1309	transcriptional regulator
E6C72_RS27970	COG0604	alcohol dehydrogenase
E6C72_RS27975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C72_RS27985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C72_RS27990	COG0861	Integral membrane protein TerC family
E6C72_RS27995	COG0673	inositol 2-dehydrogenase activity
E6C72_RS28000	COG1802	Transcriptional regulator
E6C72_RS28005	COG1902	pentaerythritol trinitrate reductase activity
E6C72_RS28005	COG0446	pyridine nucleotide-disulphide oxidoreductase
E6C72_RS28010	COG3622	Belongs to the hyi family
E6C72_RS28015	COG2084	Dehydrogenase
E6C72_RS28025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C72_RS28025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E6C72_RS28030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E6C72_RS28050	COG2972	Histidine kinase
E6C72_RS28050	COG0840	transmembrane signaling receptor activity
E6C72_RS28055	COG0300	oxidoreductase activity
E6C72_RS28060	COG0116	Belongs to the methyltransferase superfamily
E6C72_RS28060	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E6C72_RS28080	COG4178	(ABC) transporter
E6C72_RS28115	COG1988	membrane-bound metal-dependent
E6C72_RS28155	COG0477	Major facilitator Superfamily
E6C72_RS28160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E6C72_RS28165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E6C72_RS28170	COG1845	cytochrome c oxidase, subunit III
E6C72_RS28175	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E6C72_RS28190	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E6C72_RS28195	COG0351	phosphomethylpyrimidine kinase
E6C72_RS28200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E6C72_RS28215	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E6C72_RS28225	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E6C72_RS28250	COG1677	Flagellar hook-basal body complex protein FliE
E6C72_RS28255	COG1558	bacterial-type flagellum-dependent cell motility
E6C72_RS28260	COG1815	bacterial-type flagellum-dependent cell motility
E6C72_RS28305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E6C72_RS28310	COG0745	RESPONSE REGULATOR receiver
E6C72_RS28345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E6C72_RS28350	COG2017	converts alpha-aldose to the beta-anomer
E6C72_RS28355	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS28360	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C72_RS28365	COG1129	ABC transporter
E6C72_RS28370	COG1879	ABC-type sugar transport system periplasmic component
E6C72_RS28405	COG1129	ABC transporter
E6C72_RS28410	COG4214	carbohydrate transport
E6C72_RS28425	COG0129	dihydroxy-acid dehydratase activity
E6C72_RS28435	COG0251	oxidation-reduction process
E6C72_RS28445	COG1966	Carbon starvation protein
E6C72_RS28460	COG1295	ribonuclease BN
E6C72_RS28465	COG3279	Response regulator of the LytR AlgR family
E6C72_RS28470	COG3275	phosphorelay sensor kinase activity
E6C72_RS28475	COG2853	Lipoprotein
E6C72_RS28500	COG4615	Cyclic peptide transporter
E6C72_RS28560	COG0318	PFAM AMP-dependent synthetase and ligase
E6C72_RS28570	COG0644	oxidoreductase
E6C72_RS28575	COG0583	DNA-binding transcription factor activity
E6C72_RS28590	COG1192	Involved in chromosome partitioning
E6C72_RS28610	COG4221	oxidoreductase activity
E6C72_RS28610	COG3321	synthase
E6C72_RS28610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E6C72_RS28610	COG0604	alcohol dehydrogenase
E6C72_RS28625	COG1686	Belongs to the peptidase S11 family
E6C72_RS28635	COG1609	Transcriptional regulator
E6C72_RS28640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E6C72_RS28645	COG1126	abc transporter atp-binding protein
E6C72_RS28650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C72_RS28655	COG0765	amino acid transport
E6C72_RS28660	COG0765	amino acid transport
E6C72_RS28665	COG2814	Major facilitator Superfamily
E6C72_RS28670	COG2271	Major facilitator Superfamily
E6C72_RS28685	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E6C72_RS28725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C72_RS28730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C72_RS28745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E6C72_RS28795	COG1706	bacterial-type flagellum-dependent cell motility
E6C72_RS28805	COG1256	bacterial-type flagellum assembly
E6C72_RS28810	COG1749	Flagellar hook protein flgE
E6C72_RS28820	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E6C72_RS28830	COG4786	Flagellar basal body rod
E6C72_RS28835	COG4786	Flagellar basal body rod
E6C72_RS28840	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E6C72_RS28845	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E6C72_RS28885	COG1766	The M ring may be actively involved in energy transduction
E6C72_RS28895	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C72_RS28900	COG1338	Plays a role in the flagellum-specific transport system
E6C72_RS28910	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C72_RS28920	COG0656	L-ascorbic acid biosynthetic process
E6C72_RS28925	COG1116	anion transmembrane transporter activity
E6C72_RS28935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E6C72_RS28935	COG1116	anion transmembrane transporter activity
E6C72_RS28940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E6C72_RS28950	COG0243	molybdopterin cofactor binding
E6C72_RS28955	COG1648	precorrin-2 dehydrogenase activity
E6C72_RS28955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E6C72_RS28960	COG0791	NLP P60 protein
E6C72_RS28985	COG0406	alpha-ribazole phosphatase activity
E6C72_RS29000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C72_RS29005	COG1032	radical SAM domain protein
E6C72_RS29030	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C72_RS29035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E6C72_RS29040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C72_RS29045	COG1116	anion transmembrane transporter activity
E6C72_RS29050	COG0583	DNA-binding transcription factor activity
E6C72_RS29065	COG3663	DNA glycosylase
E6C72_RS29095	COG0697	spore germination
E6C72_RS29145	COG0516	GMP reductase activity
E6C72_RS29150	COG1349	DNA-binding transcription factor activity
E6C72_RS29170	COG3842	ATPase activity
E6C72_RS29175	COG3842	ATPase activity
E6C72_RS29200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E6C72_RS29205	COG0318	PFAM AMP-dependent synthetase and ligase
E6C72_RS29210	COG0789	Transcriptional regulator
E6C72_RS29230	COG4191	Histidine kinase
E6C72_RS29255	COG1238	metal cluster binding
E6C72_RS29260	COG3852	Histidine kinase
E6C72_RS29265	COG0583	DNA-binding transcription factor activity
E6C72_RS29300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C72_RS29305	COG0463	Glycosyl transferase, family 2
E6C72_RS29325	COG1940	carbohydrate kinase activity
E6C72_RS29380	COG2885	chlorophyll binding
E6C72_RS29380	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E6C72_RS29385	COG2197	response regulator
E6C72_RS29395	COG1538	Outer membrane efflux protein
E6C72_RS29400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C72_RS29425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E6C72_RS29435	COG1744	ABC transporter substrate-binding protein PnrA-like
E6C72_RS29440	COG2814	Major facilitator Superfamily
E6C72_RS29475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E6C72_RS29480	COG0625	glutathione transferase activity
E6C72_RS29490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E6C72_RS29495	COG0573	inorganic phosphate transmembrane transporter activity
E6C72_RS29500	COG0581	inorganic phosphate transmembrane transporter activity
E6C72_RS29505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E6C72_RS29510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C72_RS29510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C72_RS29515	COG1280	lysine exporter protein (LysE YggA)
E6C72_RS29530	COG1032	radical SAM domain protein
E6C72_RS29535	COG5265	(ABC) transporter
E6C72_RS29540	COG0300	oxidoreductase activity
E6C72_RS29550	COG3920	Histidine kinase
E6C72_RS29560	COG3416	Protein conserved in bacteria
E6C72_RS29575	COG0784	Response regulator, receiver
E6C72_RS29575	COG5002	protein histidine kinase activity
E6C72_RS29575	COG2205	protein histidine kinase activity
E6C72_RS29595	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E6C72_RS29610	COG3842	ATPase activity
E6C72_RS29620	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C72_RS29625	COG1802	Transcriptional regulator
E6C72_RS29630	COG0246	Mannitol dehydrogenase
E6C72_RS29635	COG1063	alcohol dehydrogenase
E6C72_RS29640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C72_RS29650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C72_RS29655	COG1312	Catalyzes the dehydration of D-mannonate
E6C72_RS29660	COG3829	transcription factor binding
E6C72_RS29660	COG3290	protein histidine kinase activity
E6C72_RS29670	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E6C72_RS29685	COG3604	Transcriptional regulator
E6C72_RS29700	COG1737	Transcriptional regulator
E6C72_RS29715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C72_RS29730	COG2205	protein histidine kinase activity
E6C72_RS29730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C72_RS29735	COG0528	UMP kinase activity
E6C72_RS29740	COG0528	UMP kinase activity
E6C72_RS29755	COG0372	Belongs to the citrate synthase family
E6C72_RS29775	COG0784	Response regulator, receiver
E6C72_RS29775	COG2205	protein histidine kinase activity
E6C72_RS29775	COG5002	protein histidine kinase activity
E6C72_RS29780	COG2204	response regulator
E6C72_RS29785	COG2186	Transcriptional regulator
E6C72_RS29790	COG1620	l-lactate permease
E6C72_RS29800	COG0247	lactate metabolic process
E6C72_RS29805	COG1139	Iron-sulfur cluster binding protein
E6C72_RS29820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C72_RS29840	COG1573	uracil-dna glycosylase
E6C72_RS29845	COG0741	lytic transglycosylase activity
E6C72_RS29850	COG0521	Mo-molybdopterin cofactor biosynthetic process
E6C72_RS29865	COG2703	oxygen carrier activity
E6C72_RS29880	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E6C72_RS29890	COG2202	Pas domain
E6C72_RS29890	COG2205	protein histidine kinase activity
E6C72_RS29910	COG3218	ABC-type transport auxiliary lipoprotein component
E6C72_RS29910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E6C72_RS29915	COG1127	ABC transporter
E6C72_RS29920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E6C72_RS29925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E6C72_RS29945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E6C72_RS29955	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E6C72_RS29960	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
E6C72_RS29975	COG0640	Transcriptional regulator
E6C72_RS30005	COG0598	Magnesium transport protein CorA
E6C72_RS30035	COG0305	Participates in initiation and elongation during chromosome replication
E6C72_RS30040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E6C72_RS30055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E6C72_RS30060	COG1127	ABC transporter
E6C72_RS30065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E6C72_RS30090	COG2723	6-phospho-beta-galactosidase activity
E6C72_RS30105	COG2086	electron transfer activity
E6C72_RS30115	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C72_RS30125	COG4993	Dehydrogenase
E6C72_RS30170	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E6C72_RS30180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E6C72_RS30195	COG0175	sulfate reduction
E6C72_RS30215	COG0438	transferase activity, transferring glycosyl groups
E6C72_RS30215	COG1216	Glycosyl transferase, family 2
E6C72_RS30220	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
E6C72_RS30230	COG1091	dTDP-4-dehydrorhamnose reductase activity
E6C72_RS30240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C72_RS30255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C72_RS30260	COG2274	protein secretion by the type I secretion system
E6C72_RS30275	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E6C72_RS30275	COG0662	Cupin 2, conserved barrel domain protein
E6C72_RS30315	COG1086	Polysaccharide biosynthesis protein
E6C72_RS30385	COG0189	ligase activity
E6C72_RS30390	COG0438	transferase activity, transferring glycosyl groups
E6C72_RS30415	COG2818	Glycosylase
E6C72_RS30430	COG1733	regulation of RNA biosynthetic process
E6C72_RS30450	COG0463	Glycosyl transferase, family 2
E6C72_RS30505	COG4638	Rieske (2fe-2S)
E6C72_RS30520	COG3622	Belongs to the hyi family
E6C72_RS30545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E6C72_RS30580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E6C72_RS30585	COG4520	surface antigen
E6C72_RS30630	COG3206	protein involved in exopolysaccharide biosynthesis
E6C72_RS30630	COG0489	protein tyrosine kinase activity
E6C72_RS30635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E6C72_RS30665	COG0438	transferase activity, transferring glycosyl groups
E6C72_RS30675	COG1215	transferase activity, transferring glycosyl groups
E6C72_RS30725	COG2850	peptidyl-arginine hydroxylation
E6C72_RS30770	COG1132	(ABC) transporter
E6C72_RS30805	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E6C72_RS30855	COG0494	nUDIX hydrolase
E6C72_RS30920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C72_RS30945	COG0438	transferase activity, transferring glycosyl groups
E6C72_RS30965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E6C72_RS30970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E6C72_RS30980	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E6C72_RS31010	COG1216	Glycosyl transferase, family 2
E6C72_RS31010	COG0438	transferase activity, transferring glycosyl groups
E6C72_RS31015	COG1216	Glycosyl transferase, family 2
E6C72_RS31035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C72_RS31055	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E6C72_RS31060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E6C72_RS31075	COG0463	Glycosyl transferase, family 2
E6C72_RS31110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E6C72_RS31115	COG2264	protein methyltransferase activity
E6C72_RS31145	COG0297	glycogen (starch) synthase activity
E6C72_RS31145	COG0438	transferase activity, transferring glycosyl groups
E6C72_RS31170	COG1192	Involved in chromosome partitioning
E6C72_RS31195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E6C72_RS31200	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E6C72_RS31215	COG1937	Protein conserved in bacteria
E6C72_RS31225	COG2217	Heavy metal translocating P-type atpase
E6C72_RS31235	COG0789	Transcriptional regulator
E6C72_RS31250	COG1686	Belongs to the peptidase S11 family
E6C72_RS31260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E6C72_RS31270	COG2321	neutral zinc metallopeptidase
E6C72_RS31280	COG3416	Protein conserved in bacteria
E6C72_RS31285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E6C72_RS31310	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E6C72_RS31485	COG3916	Acyl-homoserine-lactone synthase
E6C72_RS31570	COG1192	Involved in chromosome partitioning