locus-tag	class	description
TSH58p_RS00025	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS00050	COG5002	protein histidine kinase activity
TSH58p_RS00050	COG0784	Response regulator, receiver
TSH58p_RS00050	COG2205	protein histidine kinase activity
TSH58p_RS00060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_RS00100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TSH58p_RS00105	COG4191	Histidine kinase
TSH58p_RS00110	COG4566	intracellular signal transduction
TSH58p_RS00120	COG0848	biopolymer transport protein
TSH58p_RS00160	COG3275	phosphorelay sensor kinase activity
TSH58p_RS00175	COG1966	Carbon starvation protein
TSH58p_RS00190	COG1363	Peptidase, m42
TSH58p_RS00195	COG2918	glutathione biosynthetic process
TSH58p_RS00195	COG1181	Belongs to the D-alanine--D-alanine ligase family
TSH58p_RS00200	COG0367	asparagine synthase
TSH58p_RS00245	COG1802	Transcriptional regulator
TSH58p_RS00250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TSH58p_RS00250	COG0617	tRNA 3'-terminal CCA addition
TSH58p_RS00250	COG0517	IMP dehydrogenase activity
TSH58p_RS00260	COG0861	Integral membrane protein TerC family
TSH58p_RS00330	COG2226	methyltransferase
TSH58p_RS00350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSH58p_RS00365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TSH58p_RS00370	COG1846	Transcriptional regulator
TSH58p_RS00380	COG1309	transcriptional regulator
TSH58p_RS00385	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_RS00390	COG2186	Transcriptional regulator
TSH58p_RS00395	COG1960	acyl-CoA dehydrogenase activity
TSH58p_RS00410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TSH58p_RS00450	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_RS00460	COG1960	acyl-CoA dehydrogenase activity
TSH58p_RS00465	COG0183	Belongs to the thiolase family
TSH58p_RS00470	COG1960	acyl-CoA dehydrogenase activity
TSH58p_RS00475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TSH58p_RS00480	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TSH58p_RS00485	COG4770	biotin carboxylase activity
TSH58p_RS00515	COG2819	hydrolase of the alpha beta superfamily
TSH58p_RS00535	COG2723	6-phospho-beta-galactosidase activity
TSH58p_RS00540	COG2723	6-phospho-beta-galactosidase activity
TSH58p_RS00545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TSH58p_RS00555	COG4178	(ABC) transporter
TSH58p_RS00565	COG1216	Glycosyl transferase, family 2
TSH58p_RS00565	COG1442	glycosyl transferase family 8
TSH58p_RS00590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TSH58p_RS00610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSH58p_RS00625	COG2197	response regulator
TSH58p_RS00635	COG0643	Histidine kinase
TSH58p_RS00635	COG2198	Histidine kinase
TSH58p_RS00645	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TSH58p_RS00655	COG2201	protein-glutamate methylesterase activity
TSH58p_RS00660	COG0835	chemotaxis
TSH58p_RS00665	COG0840	transmembrane signaling receptor activity
TSH58p_RS00680	COG2095	MarC family integral membrane protein
TSH58p_RS00705	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS00710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TSH58p_RS00725	COG0395	ABC-type sugar transport system, permease component
TSH58p_RS00735	COG3842	ATPase activity
TSH58p_RS00750	COG0586	Pfam SNARE associated Golgi protein
TSH58p_RS00770	COG4615	Cyclic peptide transporter
TSH58p_RS00835	COG5002	protein histidine kinase activity
TSH58p_RS00835	COG0784	Response regulator, receiver
TSH58p_RS00840	COG4191	Histidine kinase
TSH58p_RS00840	COG0784	Response regulator, receiver
TSH58p_RS00890	COG0668	transmembrane transport
TSH58p_RS00960	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TSH58p_RS00965	COG1960	acyl-CoA dehydrogenase activity
TSH58p_RS00970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TSH58p_RS00975	COG1764	response to oxidative stress
TSH58p_RS01025	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS01050	COG0583	DNA-binding transcription factor activity
TSH58p_RS01090	COG1573	uracil-dna glycosylase
TSH58p_RS01115	COG2010	Cytochrome c
TSH58p_RS01155	COG1891	lyase activity
TSH58p_RS01175	COG1131	(ABC) transporter
TSH58p_RS01195	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
TSH58p_RS01200	COG1229	Formylmethanofuran dehydrogenase subunit A
TSH58p_RS01210	COG2154	pterin-4-alpha-carbinolamine dehydratase
TSH58p_RS01220	COG0702	epimerase
TSH58p_RS01235	COG0189	ligase activity
TSH58p_RS01245	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
TSH58p_RS01345	COG4566	intracellular signal transduction
TSH58p_RS01350	COG4191	Histidine kinase
TSH58p_RS01360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TSH58p_RS01405	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_RS01415	COG1024	Enoyl-CoA hydratase
TSH58p_RS01435	COG0183	Belongs to the thiolase family
TSH58p_RS01470	COG0683	leucine binding
TSH58p_RS01475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TSH58p_RS01480	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSH58p_RS01480	COG0022	dehydrogenase e1 component
TSH58p_RS01485	COG1024	Enoyl-CoA hydratase
TSH58p_RS01490	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSH58p_RS01515	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
TSH58p_RS01520	COG1595	DNA-templated transcription, initiation
TSH58p_RS01525	COG3712	iron ion homeostasis
TSH58p_RS01535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSH58p_RS01540	COG0577	efflux transmembrane transporter activity
TSH58p_RS01540	COG1136	(ABC) transporter
TSH58p_RS01555	COG1121	(ABC) transporter
TSH58p_RS01590	COG1126	abc transporter atp-binding protein
TSH58p_RS01615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_RS01620	COG4948	Mandelate Racemase Muconate Lactonizing
TSH58p_RS01625	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TSH58p_RS01630	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_RS01635	COG1802	Transcriptional regulator
TSH58p_RS01680	COG1595	DNA-templated transcription, initiation
TSH58p_RS01685	COG0110	maltose O-acetyltransferase activity
TSH58p_RS01690	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TSH58p_RS01710	COG2610	gluconate transmembrane transporter activity
TSH58p_RS01730	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TSH58p_RS01735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TSH58p_RS01740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TSH58p_RS01745	COG3411	Ferredoxin
TSH58p_RS01765	COG3328	transposase activity
TSH58p_RS01830	COG1024	Enoyl-CoA hydratase
TSH58p_RS01840	COG3842	ATPase activity
TSH58p_RS01845	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_RS01850	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_RS01865	COG0427	acetyl-CoA hydrolase
TSH58p_RS01895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_RS01900	COG0765	amino acid transport
TSH58p_RS01955	COG4178	(ABC) transporter
TSH58p_RS01965	COG1475	DNA binding
TSH58p_RS01970	COG1192	Involved in chromosome partitioning
TSH58p_RS01975	COG4783	chaperone-mediated protein folding
TSH58p_RS01995	COG3622	Belongs to the hyi family
TSH58p_RS02005	COG1215	transferase activity, transferring glycosyl groups
TSH58p_RS02020	COG3307	-O-antigen
TSH58p_RS02025	COG3206	protein involved in exopolysaccharide biosynthesis
TSH58p_RS02025	COG0489	protein tyrosine kinase activity
TSH58p_RS02055	COG1216	Glycosyl transferase, family 2
TSH58p_RS02125	COG0640	Transcriptional regulator
TSH58p_RS02130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TSH58p_RS02155	COG4566	intracellular signal transduction
TSH58p_RS02170	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS02190	COG1994	Peptidase M50
TSH58p_RS02190	COG0517	IMP dehydrogenase activity
TSH58p_RS02215	COG0583	DNA-binding transcription factor activity
TSH58p_RS02220	COG2271	Major facilitator Superfamily
TSH58p_RS02225	COG1802	Transcriptional regulator
TSH58p_RS02230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_RS02240	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_RS02240	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TSH58p_RS02245	COG2354	Protein conserved in bacteria
TSH58p_RS02275	COG1418	mRNA catabolic process
TSH58p_RS02280	COG1131	(ABC) transporter
TSH58p_RS02285	COG0842	Transport permease protein
TSH58p_RS02290	COG3791	Glutathione-dependent formaldehyde-activating
TSH58p_RS02295	COG0154	amidase activity
TSH58p_RS02300	COG0154	amidase activity
TSH58p_RS02305	COG1335	isochorismatase
TSH58p_RS02310	COG0747	negative chemotaxis
TSH58p_RS02315	COG0601	transmembrane transport
TSH58p_RS02320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_RS02330	COG4608	Belongs to the ABC transporter superfamily
TSH58p_RS02335	COG1335	isochorismatase
TSH58p_RS02340	COG3180	Ammonia monooxygenase
TSH58p_RS02345	COG1802	Transcriptional regulator
TSH58p_RS02355	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TSH58p_RS02360	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TSH58p_RS02365	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TSH58p_RS02370	COG2205	protein histidine kinase activity
TSH58p_RS02380	COG0861	Integral membrane protein TerC family
TSH58p_RS02395	COG2353	YceI-like domain
TSH58p_RS02405	COG1196	nuclear chromosome segregation
TSH58p_RS02415	COG4566	intracellular signal transduction
TSH58p_RS02420	COG4566	intracellular signal transduction
TSH58p_RS02425	COG4191	Histidine kinase
TSH58p_RS02440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TSH58p_RS02445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TSH58p_RS02465	COG0339	signal peptide processing
TSH58p_RS02470	COG4175	Glycine betaine
TSH58p_RS02475	COG4176	ABC-type proline glycine betaine transport system permease component
TSH58p_RS02480	COG2113	Glycine betaine
TSH58p_RS02500	COG1764	response to oxidative stress
TSH58p_RS02505	COG1846	Transcriptional regulator
TSH58p_RS02525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_RS02530	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TSH58p_RS02550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TSH58p_RS02600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TSH58p_RS02605	COG0392	lysyltransferase activity
TSH58p_RS02620	COG5001	Diguanylate cyclase
TSH58p_RS02635	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TSH58p_RS02650	COG0477	Major facilitator Superfamily
TSH58p_RS02655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TSH58p_RS02660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TSH58p_RS02665	COG1845	cytochrome c oxidase, subunit III
TSH58p_RS02670	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TSH58p_RS02685	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TSH58p_RS02700	COG3005	denitrification pathway
TSH58p_RS02725	COG4459	periplasmic nitrate reductase
TSH58p_RS02740	COG0670	Belongs to the BI1 family
TSH58p_RS02765	COG2204	response regulator
TSH58p_RS02770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_RS02780	COG1850	ribulose-bisphosphate carboxylase activity
TSH58p_RS02790	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_RS02795	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_RS02810	COG3246	L-lysine catabolic process to acetate
TSH58p_RS02815	COG0028	Belongs to the TPP enzyme family
TSH58p_RS02840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_RS02855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSH58p_RS02860	COG0583	DNA-binding transcription factor activity
TSH58p_RS02875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TSH58p_RS02890	COG0438	transferase activity, transferring glycosyl groups
TSH58p_RS02910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_RS02930	COG0438	transferase activity, transferring glycosyl groups
TSH58p_RS02935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_RS02940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_RS02945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TSH58p_RS02960	COG2197	response regulator
TSH58p_RS02965	COG2197	response regulator
TSH58p_RS02975	COG3387	PFAM Glycoside hydrolase 15-related
TSH58p_RS03005	COG2226	methyltransferase
TSH58p_RS03020	COG0784	Response regulator, receiver
TSH58p_RS03020	COG5002	protein histidine kinase activity
TSH58p_RS03025	COG0154	amidase activity
TSH58p_RS03035	COG2351	hydroxyisourate hydrolase activity
TSH58p_RS03045	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_RS03055	COG3842	ATPase activity
TSH58p_RS03095	COG0402	S-adenosylhomocysteine deaminase activity
TSH58p_RS03100	COG1116	anion transmembrane transporter activity
TSH58p_RS03105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_RS03130	COG0243	molybdopterin cofactor binding
TSH58p_RS03150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TSH58p_RS03160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TSH58p_RS03210	COG1653	transport
TSH58p_RS03225	COG3842	ATPase activity
TSH58p_RS03245	COG0840	transmembrane signaling receptor activity
TSH58p_RS03245	COG0840	transmembrane signaling receptor activity
TSH58p_RS03285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSH58p_RS03290	COG1473	amidohydrolase
TSH58p_RS03305	COG4122	O-methyltransferase activity
TSH58p_RS03335	COG1971	Probably functions as a manganese efflux pump
TSH58p_RS03340	COG0840	transmembrane signaling receptor activity
TSH58p_RS03340	COG3290	protein histidine kinase activity
TSH58p_RS03365	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS03370	COG0366	Alpha amylase catalytic
TSH58p_RS03375	COG2388	GCN5-related N-acetyl-transferase
TSH58p_RS03390	COG1139	Iron-sulfur cluster binding protein
TSH58p_RS03395	COG0247	lactate metabolic process
TSH58p_RS03400	COG0277	FAD linked oxidase domain protein
TSH58p_RS03405	COG1620	l-lactate permease
TSH58p_RS03420	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TSH58p_RS03425	COG0542	response to heat
TSH58p_RS03430	COG1414	Transcriptional regulator
TSH58p_RS03435	COG3734	2-keto-3-deoxy-galactonokinase
TSH58p_RS03440	COG0800	Aldolase
TSH58p_RS03465	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS03490	COG0784	Response regulator, receiver
TSH58p_RS03490	COG2205	protein histidine kinase activity
TSH58p_RS03490	COG5002	protein histidine kinase activity
TSH58p_RS03670	COG0741	lytic transglycosylase activity
TSH58p_RS03730	COG2204	response regulator
TSH58p_RS03800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TSH58p_RS03805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TSH58p_RS03820	COG3547	Transposase (IS116 IS110 IS902 family)
TSH58p_RS03850	COG4651	solute:proton antiporter activity
TSH58p_RS03850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TSH58p_RS03865	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TSH58p_RS03880	COG1648	precorrin-2 dehydrogenase activity
TSH58p_RS03880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TSH58p_RS03885	COG0175	sulfate reduction
TSH58p_RS03890	COG0175	sulfate reduction
TSH58p_RS03900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TSH58p_RS03900	COG1116	anion transmembrane transporter activity
TSH58p_RS03910	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TSH58p_RS03930	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_RS03935	COG0789	Transcriptional regulator
TSH58p_RS03950	COG2814	Major facilitator Superfamily
TSH58p_RS03955	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TSH58p_RS03990	COG0840	transmembrane signaling receptor activity
TSH58p_RS04020	COG2197	response regulator
TSH58p_RS04030	COG2197	response regulator
TSH58p_RS04050	COG1160	GTP binding
TSH58p_RS04055	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS04060	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TSH58p_RS04075	COG0024	Methionine aminopeptidase
TSH58p_RS04090	COG1127	ABC transporter
TSH58p_RS04095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TSH58p_RS04100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TSH58p_RS04105	COG0305	Participates in initiation and elongation during chromosome replication
TSH58p_RS04110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TSH58p_RS04115	COG0359	binds to the 23S rRNA
TSH58p_RS04125	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TSH58p_RS04130	COG0360	Binds together with S18 to 16S ribosomal RNA
TSH58p_RS04135	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TSH58p_RS04150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TSH58p_RS04155	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TSH58p_RS04165	COG0741	lytic transglycosylase activity
TSH58p_RS04170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSH58p_RS04175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TSH58p_RS04180	COG2813	Specifically methylates the guanine in position
TSH58p_RS04185	COG0113	porphobilinogen synthase activity
TSH58p_RS04190	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TSH58p_RS04195	COG1597	lipid kinase activity
TSH58p_RS04200	COG1024	Enoyl-CoA hydratase
TSH58p_RS04205	COG1846	Transcriptional regulator
TSH58p_RS04225	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_RS04240	COG0686	Belongs to the AlaDH PNT family
TSH58p_RS04250	COG0737	Belongs to the 5'-nucleotidase family
TSH58p_RS04255	COG0512	Glutamine amidotransferase of anthranilate synthase
TSH58p_RS04260	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TSH58p_RS04265	COG3608	succinylglutamate desuccinylase aspartoacylase
TSH58p_RS04265	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TSH58p_RS04300	COG2358	TRAP transporter, solute receptor (TAXI family
TSH58p_RS04335	COG0123	including yeast histone deacetylase and acetoin utilization protein
TSH58p_RS04380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TSH58p_RS04385	COG0626	cystathionine gamma-synthase activity
TSH58p_RS04390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_RS04395	COG4597	amino acid ABC transporter
TSH58p_RS04400	COG0765	amino acid transport
TSH58p_RS04405	COG1126	abc transporter atp-binding protein
TSH58p_RS04410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TSH58p_RS04430	COG2897	thiosulfate sulfurtransferase activity
TSH58p_RS04445	COG0494	nUDIX hydrolase
TSH58p_RS04450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSH58p_RS04560	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TSH58p_RS04570	COG1538	Outer membrane efflux protein
TSH58p_RS04580	COG0525	valine-tRNA ligase activity
TSH58p_RS04585	COG0840	transmembrane signaling receptor activity
TSH58p_RS04600	COG1686	Belongs to the peptidase S11 family
TSH58p_RS04605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TSH58p_RS04610	COG0470	DNA polymerase III
TSH58p_RS04620	COG0084	hydrolase, TatD family'
TSH58p_RS04625	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TSH58p_RS04625	COG0321	lipoyl(octanoyl) transferase activity
TSH58p_RS04640	COG0631	protein serine/threonine phosphatase activity
TSH58p_RS04650	COG2957	Belongs to the agmatine deiminase family
TSH58p_RS04655	COG1177	transmembrane transport
TSH58p_RS04660	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_RS04665	COG3842	ATPase activity
TSH58p_RS04675	COG0174	glutamine synthetase
TSH58p_RS04680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSH58p_RS04710	COG0861	Integral membrane protein TerC family
TSH58p_RS04720	COG4957	zinc ion binding
TSH58p_RS04755	COG1280	lysine exporter protein (LysE YggA)
TSH58p_RS04765	COG0314	molybdopterin synthase activity
TSH58p_RS04770	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TSH58p_RS04780	COG1763	Mo-molybdopterin cofactor biosynthetic process
TSH58p_RS04785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TSH58p_RS04795	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS04840	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TSH58p_RS04840	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TSH58p_RS04850	COG0564	pseudouridine synthase activity
TSH58p_RS04865	COG0784	Response regulator, receiver
TSH58p_RS04865	COG2205	protein histidine kinase activity
TSH58p_RS04865	COG2198	Histidine kinase
TSH58p_RS04870	COG2197	response regulator
TSH58p_RS04875	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TSH58p_RS04875	COG2885	chlorophyll binding
TSH58p_RS04925	COG1940	carbohydrate kinase activity
TSH58p_RS04945	COG0463	Glycosyl transferase, family 2
TSH58p_RS04975	COG1846	Transcriptional regulator
TSH58p_RS05000	COG1396	sequence-specific DNA binding
TSH58p_RS05030	COG0640	Transcriptional regulator
TSH58p_RS05045	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TSH58p_RS05055	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
TSH58p_RS05060	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TSH58p_RS05065	COG0830	nickel cation binding
TSH58p_RS05070	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
TSH58p_RS05075	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TSH58p_RS05080	COG0804	urea catabolic process
TSH58p_RS05085	COG0832	Belongs to the urease beta subunit family
TSH58p_RS05090	COG0831	urea catabolic process
TSH58p_RS05095	COG1819	glycosyl
TSH58p_RS05100	COG0829	nickel cation binding
TSH58p_RS05105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TSH58p_RS05115	COG2197	response regulator
TSH58p_RS05120	COG2197	response regulator
TSH58p_RS05125	COG0693	protein deglycase activity
TSH58p_RS05135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSH58p_RS05165	COG0574	Belongs to the PEP-utilizing enzyme family
TSH58p_RS05165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSH58p_RS05175	COG0469	pyruvate kinase activity
TSH58p_RS05180	COG1802	Transcriptional regulator
TSH58p_RS05185	COG0352	thiamine-phosphate diphosphorylase activity
TSH58p_RS05190	COG3960	tartronate-semialdehyde synthase activity
TSH58p_RS05195	COG3622	Belongs to the hyi family
TSH58p_RS05200	COG2084	Dehydrogenase
TSH58p_RS05220	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TSH58p_RS05240	COG0045	succinate-CoA ligase (ADP-forming) activity
TSH58p_RS05245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSH58p_RS05280	COG0517	IMP dehydrogenase activity
TSH58p_RS05285	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TSH58p_RS05295	COG0123	including yeast histone deacetylase and acetoin utilization protein
TSH58p_RS05310	COG0656	L-ascorbic acid biosynthetic process
TSH58p_RS05320	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TSH58p_RS05320	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TSH58p_RS05325	COG0371	Dehydrogenase
TSH58p_RS05330	COG1494	fructose-1,6-bisphosphatase
TSH58p_RS05340	COG0436	Aminotransferase
TSH58p_RS05345	COG2814	Major facilitator Superfamily
TSH58p_RS05360	COG3243	poly(R)-hydroxyalkanoic acid synthase
TSH58p_RS05365	COG2885	chlorophyll binding
TSH58p_RS05365	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TSH58p_RS05370	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TSH58p_RS05375	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TSH58p_RS05380	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TSH58p_RS05385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TSH58p_RS05395	COG1024	Enoyl-CoA hydratase
TSH58p_RS05400	COG1832	CoA-binding protein
TSH58p_RS05435	COG2205	protein histidine kinase activity
TSH58p_RS05470	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS05480	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS05495	COG2358	TRAP transporter, solute receptor (TAXI family
TSH58p_RS05500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_RS05520	COG0436	Aminotransferase
TSH58p_RS05535	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TSH58p_RS05550	COG0728	peptidoglycan biosynthetic process
TSH58p_RS05555	COG0596	Alpha beta hydrolase
TSH58p_RS05585	COG2986	histidine ammonia-lyase
TSH58p_RS05610	COG0037	tRNA processing
TSH58p_RS05620	COG0148	phosphopyruvate hydratase activity
TSH58p_RS05630	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TSH58p_RS05635	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
TSH58p_RS05640	COG0535	radical SAM domain protein
TSH58p_RS05645	COG0535	radical SAM domain protein
TSH58p_RS05680	COG0149	triose-phosphate isomerase activity
TSH58p_RS05690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TSH58p_RS05735	COG0315	cyclic pyranopterin monophosphate synthase activity
TSH58p_RS05740	COG0303	'Molybdopterin
TSH58p_RS05745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TSH58p_RS05750	COG0658	competence protein
TSH58p_RS05750	COG2333	competence protein COMEC
TSH58p_RS05755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TSH58p_RS05760	COG0372	Belongs to the citrate synthase family
TSH58p_RS05775	COG0583	DNA-binding transcription factor activity
TSH58p_RS05790	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TSH58p_RS05795	COG3494	Protein of unknown function (DUF1009)
TSH58p_RS05800	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TSH58p_RS05820	COG0750	zinc metalloprotease
TSH58p_RS05825	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TSH58p_RS05835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TSH58p_RS05840	COG0233	cytoplasmic translational termination
TSH58p_RS05845	COG0528	UMP kinase activity
TSH58p_RS05850	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TSH58p_RS05855	COG0052	Belongs to the universal ribosomal protein uS2 family
TSH58p_RS05890	COG0442	prolyl-tRNA aminoacylation
TSH58p_RS05905	COG0519	Catalyzes the synthesis of GMP from XMP
TSH58p_RS05915	COG0346	lactoylglutathione lyase activity
TSH58p_RS05935	COG1007	ATP synthesis coupled electron transport
TSH58p_RS05950	COG0713	ATP synthesis coupled electron transport
TSH58p_RS05960	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSH58p_RS05965	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TSH58p_RS05970	COG1034	ATP synthesis coupled electron transport
TSH58p_RS05985	COG0649	NAD binding
TSH58p_RS05995	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSH58p_RS06000	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSH58p_RS06050	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TSH58p_RS06050	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TSH58p_RS06075	COG0443	Heat shock 70 kDa protein
TSH58p_RS06080	COG2030	dehydratase
TSH58p_RS06080	COG1012	belongs to the aldehyde dehydrogenase family
TSH58p_RS06100	COG0670	Belongs to the BI1 family
TSH58p_RS06115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSH58p_RS06120	COG0351	phosphomethylpyrimidine kinase
TSH58p_RS06120	COG0352	thiamine-phosphate diphosphorylase activity
TSH58p_RS06125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TSH58p_RS06130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TSH58p_RS06140	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TSH58p_RS06145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TSH58p_RS06160	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TSH58p_RS06165	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TSH58p_RS06205	COG1079	Belongs to the binding-protein-dependent transport system permease family
TSH58p_RS06210	COG4603	Belongs to the binding-protein-dependent transport system permease family
TSH58p_RS06215	COG3845	ABC transporter
TSH58p_RS06220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TSH58p_RS06245	COG0546	phosphoglycolate phosphatase activity
TSH58p_RS06250	COG3135	benzoate transporter
TSH58p_RS06255	COG1802	Transcriptional regulator
TSH58p_RS06260	COG0564	pseudouridine synthase activity
TSH58p_RS06265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TSH58p_RS06280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TSH58p_RS06295	COG1238	metal cluster binding
TSH58p_RS06300	COG0203	ribosomal protein L17
TSH58p_RS06315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TSH58p_RS06320	COG0469	pyruvate kinase activity
TSH58p_RS06330	COG1238	metal cluster binding
TSH58p_RS06335	COG2832	Protein of unknown function (DUF454)
TSH58p_RS06345	COG0521	Mo-molybdopterin cofactor biosynthetic process
TSH58p_RS06360	COG0546	phosphoglycolate phosphatase activity
TSH58p_RS06375	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS06380	COG2084	Dehydrogenase
TSH58p_RS06395	COG1733	regulation of RNA biosynthetic process
TSH58p_RS06410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TSH58p_RS06415	COG2261	transglycosylase associated protein
TSH58p_RS06420	COG0784	Response regulator, receiver
TSH58p_RS06430	COG2135	peptidase activity
TSH58p_RS06440	COG2199	diguanylate cyclase activity
TSH58p_RS06440	COG2200	EAL domain
TSH58p_RS06440	COG2203	Gaf domain
TSH58p_RS06450	COG0366	Alpha amylase catalytic
TSH58p_RS06455	COG2326	polyphosphate kinase activity
TSH58p_RS06465	COG0038	chloride channel
TSH58p_RS06480	COG0411	ABC transporter
TSH58p_RS06500	COG0697	spore germination
TSH58p_RS06515	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TSH58p_RS06520	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TSH58p_RS06525	COG0295	cytidine deaminase activity
TSH58p_RS06530	COG1079	Belongs to the binding-protein-dependent transport system permease family
TSH58p_RS06535	COG4603	Belongs to the binding-protein-dependent transport system permease family
TSH58p_RS06540	COG3845	ABC transporter
TSH58p_RS06545	COG1744	ABC transporter substrate-binding protein PnrA-like
TSH58p_RS06560	COG0840	transmembrane signaling receptor activity
TSH58p_RS06565	COG0768	penicillin binding
TSH58p_RS06585	COG2862	Uncharacterized protein family, UPF0114
TSH58p_RS06590	COG0704	Plays a role in the regulation of phosphate uptake
TSH58p_RS06605	COG0028	Belongs to the TPP enzyme family
TSH58p_RS06610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSH58p_RS06615	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TSH58p_RS06640	COG0330	HflC and HflK could
TSH58p_RS06645	COG0330	HflC and HflK could
TSH58p_RS06650	COG0489	protein tyrosine kinase activity
TSH58p_RS06665	COG4120	Belongs to the binding-protein-dependent transport system permease family
TSH58p_RS06690	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TSH58p_RS06705	COG3070	regulator of competence-specific genes
TSH58p_RS06715	COG0242	peptide deformylase activity
TSH58p_RS06720	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TSH58p_RS06725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TSH58p_RS06850	COG0840	transmembrane signaling receptor activity
TSH58p_RS06855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TSH58p_RS06860	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TSH58p_RS06865	COG0343	queuine tRNA-ribosyltransferase activity
TSH58p_RS06870	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TSH58p_RS06875	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TSH58p_RS06895	COG0840	transmembrane signaling receptor activity
TSH58p_RS06905	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_RS06950	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS06950	COG3321	synthase
TSH58p_RS06950	COG0604	alcohol dehydrogenase
TSH58p_RS06965	COG0288	reversible hydration of carbon dioxide
TSH58p_RS06995	COG0205	6-phosphofructokinase activity
TSH58p_RS07010	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TSH58p_RS07015	COG5001	Diguanylate cyclase
TSH58p_RS07030	COG0114	fumarate hydratase activity
TSH58p_RS07045	COG0456	acetyltransferase
TSH58p_RS07055	COG0438	transferase activity, transferring glycosyl groups
TSH58p_RS07080	COG1454	alcohol dehydrogenase
TSH58p_RS07100	COG2951	lytic endotransglycosylase activity
TSH58p_RS07110	COG0432	Pfam Uncharacterised protein family UPF0047
TSH58p_RS07135	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS07145	COG5002	protein histidine kinase activity
TSH58p_RS07150	COG2010	Cytochrome c
TSH58p_RS07150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TSH58p_RS07155	COG2080	2 iron, 2 sulfur cluster binding
TSH58p_RS07160	COG2010	Cytochrome c
TSH58p_RS07160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TSH58p_RS07170	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TSH58p_RS07180	COG4221	oxidoreductase activity
TSH58p_RS07205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSH58p_RS07375	COG0456	acetyltransferase
TSH58p_RS07450	COG0482	sulfurtransferase activity
TSH58p_RS07455	COG0633	Ferredoxin
TSH58p_RS07460	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TSH58p_RS07475	COG1045	serine acetyltransferase
TSH58p_RS07480	COG2945	thiolester hydrolase activity
TSH58p_RS07485	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TSH58p_RS07505	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TSH58p_RS07510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TSH58p_RS07515	COG1192	Involved in chromosome partitioning
TSH58p_RS07520	COG0009	L-threonylcarbamoyladenylate synthase
TSH58p_RS07535	COG0277	FAD linked oxidase domain protein
TSH58p_RS07550	COG1960	acyl-CoA dehydrogenase activity
TSH58p_RS07570	COG0247	lactate metabolic process
TSH58p_RS07575	COG0277	FAD linked oxidase domain protein
TSH58p_RS07580	COG0277	FAD linked oxidase domain protein
TSH58p_RS07590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TSH58p_RS07600	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
TSH58p_RS07605	COG0842	Transport permease protein
TSH58p_RS07615	COG1131	(ABC) transporter
TSH58p_RS07625	COG1309	transcriptional regulator
TSH58p_RS07645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TSH58p_RS07660	COG5554	nitrogen fixation
TSH58p_RS07685	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TSH58p_RS07700	COG0121	glutamine amidotransferase
TSH58p_RS07755	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
TSH58p_RS07760	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
TSH58p_RS07775	COG5420	small protein containing a coiled-coil domain
TSH58p_RS07835	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TSH58p_RS07860	COG5002	protein histidine kinase activity
TSH58p_RS07860	COG2205	protein histidine kinase activity
TSH58p_RS07860	COG0784	Response regulator, receiver
TSH58p_RS07870	COG1278	Cold shock
TSH58p_RS07875	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TSH58p_RS07880	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TSH58p_RS07890	COG0840	transmembrane signaling receptor activity
TSH58p_RS07905	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TSH58p_RS07920	COG2154	pterin-4-alpha-carbinolamine dehydratase
TSH58p_RS07930	COG1104	cysteine desulfurase activity
TSH58p_RS07940	COG4948	Mandelate Racemase Muconate Lactonizing
TSH58p_RS07965	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TSH58p_RS07970	COG2894	cell division
TSH58p_RS07975	COG0850	regulation of cytokinetic process
TSH58p_RS07980	COG1702	phosphate starvation-inducible protein PhoH
TSH58p_RS07995	COG1999	signal sequence binding
TSH58p_RS08005	COG0356	it plays a direct role in the translocation of protons across the membrane
TSH58p_RS08010	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TSH58p_RS08015	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TSH58p_RS08025	COG3384	dioxygenase
TSH58p_RS08035	COG0235	Class ii aldolase
TSH58p_RS08060	COG0437	4 iron, 4 sulfur cluster binding
TSH58p_RS08065	COG0243	molybdopterin cofactor binding
TSH58p_RS08065	COG3383	formate dehydrogenase (NAD+) activity
TSH58p_RS08090	COG0746	molybdenum cofactor guanylyltransferase activity
TSH58p_RS08095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TSH58p_RS08110	COG1686	Belongs to the peptidase S11 family
TSH58p_RS08135	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TSH58p_RS08150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSH58p_RS08160	COG0590	tRNA wobble adenosine to inosine editing
TSH58p_RS08185	COG2703	oxygen carrier activity
TSH58p_RS08190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TSH58p_RS08225	COG2030	dehydratase
TSH58p_RS08230	COG0196	riboflavin kinase activity
TSH58p_RS08240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TSH58p_RS08245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TSH58p_RS08250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TSH58p_RS08260	COG0612	Peptidase, M16
TSH58p_RS08265	COG0612	Peptidase, M16
TSH58p_RS08275	COG0166	Belongs to the GPI family
TSH58p_RS08295	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TSH58p_RS08305	COG0596	Alpha beta hydrolase
TSH58p_RS08305	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSH58p_RS08310	COG0022	dehydrogenase e1 component
TSH58p_RS08315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TSH58p_RS08320	COG3199	ATP-NAD kinase
TSH58p_RS08325	COG3284	Transcriptional regulator
TSH58p_RS08335	COG0604	alcohol dehydrogenase
TSH58p_RS08340	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_RS08390	COG1609	Transcriptional regulator
TSH58p_RS08395	COG3608	succinylglutamate desuccinylase aspartoacylase
TSH58p_RS08400	COG0251	oxidation-reduction process
TSH58p_RS08415	COG4597	amino acid ABC transporter
TSH58p_RS08420	COG0765	amino acid transport
TSH58p_RS08450	COG1116	anion transmembrane transporter activity
TSH58p_RS08460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TSH58p_RS08470	COG0628	permease
TSH58p_RS08480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TSH58p_RS08495	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TSH58p_RS08565	COG0667	Aldo Keto reductase
TSH58p_RS08575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_RS08585	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TSH58p_RS08590	COG1749	Flagellar hook protein flgE
TSH58p_RS08615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TSH58p_RS08665	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TSH58p_RS08680	COG0742	ribosomal rna small subunit methyltransferase
TSH58p_RS08685	COG1187	pseudouridine synthase activity
TSH58p_RS08690	COG3360	Dodecin
TSH58p_RS08695	COG0590	tRNA wobble adenosine to inosine editing
TSH58p_RS08710	COG1570	exodeoxyribonuclease VII activity
TSH58p_RS08715	COG0418	dihydroorotase activity
TSH58p_RS08720	COG0124	histidyl-tRNA synthetase
TSH58p_RS08765	COG1546	Belongs to the CinA family
TSH58p_RS08765	COG1058	Belongs to the CinA family
TSH58p_RS08770	COG1489	DNA binding
TSH58p_RS08775	COG0024	Methionine aminopeptidase
TSH58p_RS08780	COG2003	Belongs to the UPF0758 family
TSH58p_RS08795	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TSH58p_RS08810	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TSH58p_RS08815	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TSH58p_RS08825	COG2258	MOSC domain
TSH58p_RS08835	COG0583	DNA-binding transcription factor activity
TSH58p_RS08840	COG0047	phosphoribosylformylglycinamidine synthase activity
TSH58p_RS08845	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TSH58p_RS08855	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TSH58p_RS08865	COG2962	Rard protein
TSH58p_RS08875	COG1902	pentaerythritol trinitrate reductase activity
TSH58p_RS08890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TSH58p_RS08910	COG3279	Response regulator of the LytR AlgR family
TSH58p_RS08920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TSH58p_RS08930	COG5002	protein histidine kinase activity
TSH58p_RS08950	COG2205	protein histidine kinase activity
TSH58p_RS08950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_RS08965	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
TSH58p_RS08990	COG1012	belongs to the aldehyde dehydrogenase family
TSH58p_RS09010	COG1238	metal cluster binding
TSH58p_RS09015	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS09020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TSH58p_RS09030	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TSH58p_RS09050	COG1674	ftsk spoiiie
TSH58p_RS09075	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TSH58p_RS09080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TSH58p_RS09090	COG1522	sequence-specific DNA binding
TSH58p_RS09095	COG3660	Nucleoside-diphosphate-sugar epimerase
TSH58p_RS09110	COG0492	ferredoxin-NADP+ reductase activity
TSH58p_RS09120	COG0783	Belongs to the Dps family
TSH58p_RS09130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TSH58p_RS09135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TSH58p_RS09190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_RS09195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_RS09200	COG1116	anion transmembrane transporter activity
TSH58p_RS09210	COG2081	HI0933 family
TSH58p_RS09220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TSH58p_RS09225	COG2814	Major facilitator Superfamily
TSH58p_RS09230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TSH58p_RS09280	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TSH58p_RS09285	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TSH58p_RS09290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TSH58p_RS09300	COG0167	dihydroorotate dehydrogenase activity
TSH58p_RS09415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TSH58p_RS09450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TSH58p_RS09460	COG2084	Dehydrogenase
TSH58p_RS09475	COG0840	transmembrane signaling receptor activity
TSH58p_RS09475	COG2972	Histidine kinase
TSH58p_RS09480	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TSH58p_RS09490	COG0840	transmembrane signaling receptor activity
TSH58p_RS09500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TSH58p_RS09510	COG2076	Multidrug Resistance protein
TSH58p_RS09515	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TSH58p_RS09530	COG0039	L-malate dehydrogenase activity
TSH58p_RS09535	COG0045	succinate-CoA ligase (ADP-forming) activity
TSH58p_RS09550	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSH58p_RS09555	COG2205	protein histidine kinase activity
TSH58p_RS09560	COG3706	GGDEF domain
TSH58p_RS09565	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TSH58p_RS09580	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
TSH58p_RS09630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TSH58p_RS09635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSH58p_RS09640	COG0552	protein localization to endoplasmic reticulum
TSH58p_RS09645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TSH58p_RS09655	COG2917	probably involved in intracellular septation
TSH58p_RS09670	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS09675	COG2176	DNA-directed DNA polymerase activity
TSH58p_RS09675	COG5002	protein histidine kinase activity
TSH58p_RS09685	COG5002	protein histidine kinase activity
TSH58p_RS09695	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS09700	COG0643	Histidine kinase
TSH58p_RS09700	COG2198	Histidine kinase
TSH58p_RS09705	COG0835	chemotaxis
TSH58p_RS09715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TSH58p_RS09720	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TSH58p_RS09725	COG2201	protein-glutamate methylesterase activity
TSH58p_RS09735	COG1366	Belongs to the anti-sigma-factor antagonist family
TSH58p_RS09750	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS09770	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS09790	COG2205	protein histidine kinase activity
TSH58p_RS09790	COG0784	Response regulator, receiver
TSH58p_RS09790	COG5002	protein histidine kinase activity
TSH58p_RS09810	COG0513	Belongs to the DEAD box helicase family
TSH58p_RS09825	COG0625	glutathione transferase activity
TSH58p_RS09830	COG3842	ATPase activity
TSH58p_RS09835	COG0395	ABC-type sugar transport system, permease component
TSH58p_RS09855	COG2205	protein histidine kinase activity
TSH58p_RS09855	COG0784	Response regulator, receiver
TSH58p_RS09865	COG2814	Major facilitator Superfamily
TSH58p_RS09870	COG1285	pathogenesis
TSH58p_RS09905	COG2835	tetraacyldisaccharide 4'-kinase activity
TSH58p_RS09910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TSH58p_RS09915	COG3118	belongs to the thioredoxin family
TSH58p_RS09920	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
TSH58p_RS09930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TSH58p_RS09955	COG2770	Histidine kinase
TSH58p_RS09955	COG3437	response regulator, receiver
TSH58p_RS09960	COG2902	Dehydrogenase
TSH58p_RS09965	COG2264	protein methyltransferase activity
TSH58p_RS09990	COG0138	bifunctional purine biosynthesis protein purh
TSH58p_RS10000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TSH58p_RS10000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TSH58p_RS10015	COG0501	Belongs to the peptidase M48B family
TSH58p_RS10020	COG5508	conserved small protein
TSH58p_RS10035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TSH58p_RS10050	COG2350	Protein conserved in bacteria
TSH58p_RS10055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TSH58p_RS10070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TSH58p_RS10075	COG0181	hydroxymethylbilane synthase activity
TSH58p_RS10105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSH58p_RS10135	COG2885	chlorophyll binding
TSH58p_RS10145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TSH58p_RS10155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_RS10155	COG4191	Histidine kinase
TSH58p_RS10160	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TSH58p_RS10185	COG5002	protein histidine kinase activity
TSH58p_RS10200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_RS10230	COG2967	ApaG domain
TSH58p_RS10235	COG0302	gtp cyclohydrolase
TSH58p_RS10245	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TSH58p_RS10265	COG0444	Belongs to the ABC transporter superfamily
TSH58p_RS10270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_RS10275	COG0601	transmembrane transport
TSH58p_RS10285	COG0747	negative chemotaxis
TSH58p_RS10345	COG0671	phosphoesterase, PA-phosphatase related
TSH58p_RS10355	COG0784	Response regulator, receiver
TSH58p_RS10355	COG3437	response regulator, receiver
TSH58p_RS10370	COG1983	PspC domain protein
TSH58p_RS10380	COG1842	Phage shock protein A
TSH58p_RS10385	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TSH58p_RS10395	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TSH58p_RS10410	COG3005	denitrification pathway
TSH58p_RS10415	COG1858	cytochrome C peroxidase
TSH58p_RS10420	COG0753	catalase activity
TSH58p_RS10425	COG0459	protein refolding
TSH58p_RS10430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TSH58p_RS10435	COG5425	PFAM Usg family protein
TSH58p_RS10440	COG3772	lysozyme
TSH58p_RS10445	COG0493	'glutamate synthase
TSH58p_RS10445	COG0543	2 iron, 2 sulfur cluster binding
TSH58p_RS10450	COG1612	heme a metabolic process
TSH58p_RS10475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_RS10480	COG4608	Belongs to the ABC transporter superfamily
TSH58p_RS10485	COG0668	transmembrane transport
TSH58p_RS10490	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TSH58p_RS10495	COG4181	ATPase activity
TSH58p_RS10510	COG0667	Aldo Keto reductase
TSH58p_RS10515	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TSH58p_RS10520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TSH58p_RS10525	COG0347	Belongs to the P(II) protein family
TSH58p_RS10530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TSH58p_RS10550	COG0606	chelatase, subunit chli
TSH58p_RS10560	COG0747	negative chemotaxis
TSH58p_RS10570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_RS10575	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TSH58p_RS10610	COG2304	oxidoreductase activity
TSH58p_RS10620	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSH58p_RS10625	COG0674	pyruvate-flavodoxin oxidoreductase activity
TSH58p_RS10625	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TSH58p_RS10630	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TSH58p_RS10640	COG2202	Pas domain
TSH58p_RS10640	COG2205	protein histidine kinase activity
TSH58p_RS10645	COG0693	protein deglycase activity
TSH58p_RS10650	COG2224	Isocitrate lyase
TSH58p_RS10655	COG1396	sequence-specific DNA binding
TSH58p_RS10655	COG3800	Transcriptional regulator
TSH58p_RS10670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TSH58p_RS10675	COG3437	response regulator, receiver
TSH58p_RS10675	COG0784	Response regulator, receiver
TSH58p_RS10680	COG3706	GGDEF domain
TSH58p_RS10685	COG0484	heat shock protein binding
TSH58p_RS10690	COG0443	Heat shock 70 kDa protein
TSH58p_RS10720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TSH58p_RS10725	COG1420	regulation of RNA biosynthetic process
TSH58p_RS10730	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TSH58p_RS10735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TSH58p_RS10740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TSH58p_RS10750	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TSH58p_RS10775	COG0792	nuclease activity
TSH58p_RS10780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TSH58p_RS10800	COG1366	Belongs to the anti-sigma-factor antagonist family
TSH58p_RS10810	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TSH58p_RS10865	COG0180	Tryptophanyl-tRNA synthetase
TSH58p_RS10870	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TSH58p_RS10880	COG3012	SEC-C Motif Domain Protein
TSH58p_RS10895	COG0110	maltose O-acetyltransferase activity
TSH58p_RS10900	COG1309	transcriptional regulator
TSH58p_RS10905	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS10920	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TSH58p_RS10925	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TSH58p_RS10930	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TSH58p_RS10950	COG0406	alpha-ribazole phosphatase activity
TSH58p_RS10955	COG0438	transferase activity, transferring glycosyl groups
TSH58p_RS10960	COG3706	GGDEF domain
TSH58p_RS10975	COG1132	(ABC) transporter
TSH58p_RS10980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_RS10980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TSH58p_RS11000	COG4172	Belongs to the ABC transporter superfamily
TSH58p_RS11010	COG0601	transmembrane transport
TSH58p_RS11015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_RS11025	COG1234	tRNA 3'-trailer cleavage
TSH58p_RS11045	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS11125	COG0357	Ribosomal RNA small subunit methyltransferase G
TSH58p_RS11130	COG0445	tRNA wobble uridine modification
TSH58p_RS11140	COG3411	Ferredoxin
TSH58p_RS11150	COG1331	Highly conserved protein containing a thioredoxin domain
TSH58p_RS11165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TSH58p_RS11170	COG0237	dephospho-CoA kinase activity
TSH58p_RS11195	COG1981	membrane
TSH58p_RS11205	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TSH58p_RS11210	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TSH58p_RS11220	COG4395	Tim44
TSH58p_RS11225	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
TSH58p_RS11280	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TSH58p_RS11285	COG0488	(ABC) transporter
TSH58p_RS11290	COG2205	protein histidine kinase activity
TSH58p_RS11310	COG1139	Iron-sulfur cluster binding protein
TSH58p_RS11315	COG0247	lactate metabolic process
TSH58p_RS11335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TSH58p_RS11340	COG1121	(ABC) transporter
TSH58p_RS11350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TSH58p_RS11355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TSH58p_RS11365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TSH58p_RS11380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TSH58p_RS11385	COG0730	response to heat
TSH58p_RS11410	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TSH58p_RS11420	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
TSH58p_RS11425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TSH58p_RS11455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSH58p_RS11460	COG1702	phosphate starvation-inducible protein PhoH
TSH58p_RS11470	COG1253	flavin adenine dinucleotide binding
TSH58p_RS11475	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TSH58p_RS11480	COG1396	sequence-specific DNA binding
TSH58p_RS11485	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TSH58p_RS11490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TSH58p_RS11495	COG2329	Antibiotic biosynthesis monooxygenase
TSH58p_RS11500	COG0779	Required for maturation of 30S ribosomal subunits
TSH58p_RS11525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TSH58p_RS11535	COG1185	polyribonucleotide nucleotidyltransferase activity
TSH58p_RS11550	COG2321	neutral zinc metallopeptidase
TSH58p_RS11560	COG1509	lysine 2,3-aminomutase activity
TSH58p_RS11565	COG0584	glycerophosphoryl diester phosphodiesterase
TSH58p_RS11580	COG1592	Rubrerythrin
TSH58p_RS11605	COG0039	L-malate dehydrogenase activity
TSH58p_RS11610	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TSH58p_RS11615	COG4166	transmembrane transport
TSH58p_RS11625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TSH58p_RS11630	COG2226	methyltransferase
TSH58p_RS11635	COG0859	PFAM glycosyl transferase family 9
TSH58p_RS11635	COG0457	Tetratricopeptide repeat
TSH58p_RS11640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TSH58p_RS11650	COG1024	Enoyl-CoA hydratase
TSH58p_RS11655	COG0268	Binds directly to 16S ribosomal RNA
TSH58p_RS11660	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TSH58p_RS11670	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TSH58p_RS11675	COG3842	ATPase activity
TSH58p_RS11695	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_RS11700	COG1177	transmembrane transport
TSH58p_RS11715	COG2132	Multicopper oxidase
TSH58p_RS11735	COG3278	Belongs to the heme-copper respiratory oxidase family
TSH58p_RS11765	COG2217	Heavy metal translocating P-type atpase
TSH58p_RS11775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_RS11780	COG0281	malic enzyme
TSH58p_RS11780	COG0280	phosphate acetyltransferase
TSH58p_RS11785	COG5002	protein histidine kinase activity
TSH58p_RS11790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TSH58p_RS11795	COG0573	inorganic phosphate transmembrane transporter activity
TSH58p_RS11805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TSH58p_RS11815	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS11830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TSH58p_RS11840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TSH58p_RS11850	COG0756	dUTP diphosphatase activity
TSH58p_RS11855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TSH58p_RS11860	COG2204	response regulator
TSH58p_RS11865	COG1278	Cold shock
TSH58p_RS11870	COG0784	Response regulator, receiver
TSH58p_RS11870	COG5002	protein histidine kinase activity
TSH58p_RS11870	COG2205	protein histidine kinase activity
TSH58p_RS11875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TSH58p_RS11880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TSH58p_RS11880	COG1321	iron dependent repressor
TSH58p_RS11885	COG1121	(ABC) transporter
TSH58p_RS11890	COG0803	Belongs to the bacterial solute-binding protein 9 family
TSH58p_RS11950	COG1253	flavin adenine dinucleotide binding
TSH58p_RS11965	COG0477	Major facilitator Superfamily
TSH58p_RS11970	COG0583	DNA-binding transcription factor activity
TSH58p_RS11975	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TSH58p_RS11995	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TSH58p_RS12015	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TSH58p_RS12020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TSH58p_RS12025	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TSH58p_RS12040	COG3437	response regulator, receiver
TSH58p_RS12040	COG0784	Response regulator, receiver
TSH58p_RS12050	COG0583	DNA-binding transcription factor activity
TSH58p_RS12060	COG0481	GTPase activity
TSH58p_RS12070	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TSH58p_RS12075	COG0297	glycogen (starch) synthase activity
TSH58p_RS12080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TSH58p_RS12085	COG0004	ammonium transporteR
TSH58p_RS12115	COG3806	Anti-sigma factor
TSH58p_RS12120	COG1595	DNA-templated transcription, initiation
TSH58p_RS12130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TSH58p_RS12145	COG0137	argininosuccinate synthase activity
TSH58p_RS12165	COG3339	Conserved Protein
TSH58p_RS12170	COG0697	spore germination
TSH58p_RS12175	COG4235	cytochrome complex assembly
TSH58p_RS12180	COG3088	subunit of a heme lyase
TSH58p_RS12185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TSH58p_RS12190	COG1138	Cytochrome C-type biogenesis protein
TSH58p_RS12195	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TSH58p_RS12205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TSH58p_RS12235	COG2985	domain, Protein
TSH58p_RS12240	COG2985	domain, Protein
TSH58p_RS12245	COG4133	protoheme IX ABC transporter activity
TSH58p_RS12250	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TSH58p_RS12255	COG1715	Restriction endonuclease
TSH58p_RS12270	COG1872	DUF167
TSH58p_RS12275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TSH58p_RS12280	COG0598	Magnesium transport protein CorA
TSH58p_RS12290	COG2154	pterin-4-alpha-carbinolamine dehydratase
TSH58p_RS12300	COG1573	uracil-dna glycosylase
TSH58p_RS12305	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TSH58p_RS12310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TSH58p_RS12315	COG3001	Fructosamine kinase
TSH58p_RS12325	COG0583	DNA-binding transcription factor activity
TSH58p_RS12335	COG1074	ATP-dependent DNA helicase activity
TSH58p_RS12340	COG2887	Belongs to the helicase family. UvrD subfamily
TSH58p_RS12345	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TSH58p_RS12355	COG0802	atpase or kinase
TSH58p_RS12385	COG1252	NADH dehydrogenase
TSH58p_RS12390	COG2205	protein histidine kinase activity
TSH58p_RS12395	COG2205	protein histidine kinase activity
TSH58p_RS12395	COG5002	protein histidine kinase activity
TSH58p_RS12395	COG0784	Response regulator, receiver
TSH58p_RS12400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_RS12405	COG0133	tryptophan synthase activity
TSH58p_RS12415	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TSH58p_RS12420	COG0285	dihydrofolate synthase activity
TSH58p_RS12450	COG2205	protein histidine kinase activity
TSH58p_RS12455	COG0302	gtp cyclohydrolase
TSH58p_RS12490	COG1278	Cold shock
TSH58p_RS12495	COG0033	Phosphoglucomutase
TSH58p_RS12500	COG0412	Dienelactone hydrolase
TSH58p_RS12510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TSH58p_RS12540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_RS12550	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TSH58p_RS12550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_RS12575	COG0514	ATP-dependent DNA helicase (RecQ)
TSH58p_RS12580	COG0494	nUDIX hydrolase
TSH58p_RS12590	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TSH58p_RS12595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TSH58p_RS12600	COG0653	protein targeting
TSH58p_RS12605	COG1970	mechanosensitive ion channel activity
TSH58p_RS12610	COG0513	Belongs to the DEAD box helicase family
TSH58p_RS12615	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TSH58p_RS12635	COG4106	trans-aconitate 2-methyltransferase activity
TSH58p_RS12640	COG1987	bacterial-type flagellum assembly
TSH58p_RS12645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TSH58p_RS12650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TSH58p_RS12655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TSH58p_RS12660	COG1971	Probably functions as a manganese efflux pump
TSH58p_RS12675	COG3162	membrane
TSH58p_RS12710	COG1012	belongs to the aldehyde dehydrogenase family
TSH58p_RS12760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TSH58p_RS12785	COG0071	Belongs to the small heat shock protein (HSP20) family
TSH58p_RS12795	COG0463	Glycosyl transferase, family 2
TSH58p_RS12805	COG2205	protein histidine kinase activity
TSH58p_RS12805	COG5002	protein histidine kinase activity
TSH58p_RS12805	COG0784	Response regulator, receiver
TSH58p_RS12825	COG1741	Belongs to the pirin family
TSH58p_RS12850	COG0405	Gamma-glutamyltransferase
TSH58p_RS12865	COG0539	negative regulation of cytoplasmic translation
TSH58p_RS12875	COG0776	regulation of translation
TSH58p_RS12885	COG2423	ornithine cyclodeaminase activity
TSH58p_RS12905	COG0135	phosphoribosylanthranilate isomerase activity
TSH58p_RS12915	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TSH58p_RS12920	COG1178	ABC-type Fe3 transport system permease component
TSH58p_RS12925	COG1741	Belongs to the pirin family
TSH58p_RS12930	COG1840	ABC-type Fe3 transport system, periplasmic component
TSH58p_RS12960	COG0271	Belongs to the BolA IbaG family
TSH58p_RS12975	COG0517	IMP dehydrogenase activity
TSH58p_RS12980	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TSH58p_RS13000	COG4974	Belongs to the 'phage' integrase family
TSH58p_RS13005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TSH58p_RS13015	COG0825	malonyl-CoA metabolic process
TSH58p_RS13030	COG0598	Magnesium transport protein CorA
TSH58p_RS13040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TSH58p_RS13055	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TSH58p_RS13060	COG0706	membrane insertase activity
TSH58p_RS13065	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TSH58p_RS13075	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TSH58p_RS13085	COG1215	transferase activity, transferring glycosyl groups
TSH58p_RS13115	COG0438	transferase activity, transferring glycosyl groups
TSH58p_RS13130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_RS13140	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TSH58p_RS13150	COG0489	protein tyrosine kinase activity
TSH58p_RS13150	COG3206	protein involved in exopolysaccharide biosynthesis
TSH58p_RS13170	COG0697	spore germination
TSH58p_RS13175	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TSH58p_RS13185	COG1131	(ABC) transporter
TSH58p_RS13195	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TSH58p_RS13210	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TSH58p_RS13225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSH58p_RS13265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TSH58p_RS13270	COG0228	four-way junction DNA binding
TSH58p_RS13275	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TSH58p_RS13285	COG0335	large ribosomal subunit rRNA binding
TSH58p_RS13300	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TSH58p_RS13305	COG2378	regulation of single-species biofilm formation
TSH58p_RS13325	COG0101	tRNA pseudouridine synthase activity
TSH58p_RS13330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TSH58p_RS13335	COG0242	peptide deformylase activity
TSH58p_RS13345	COG1278	Cold shock
TSH58p_RS13350	COG1322	Protein conserved in bacteria
TSH58p_RS13365	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS13380	COG0156	8-amino-7-oxononanoate synthase activity
TSH58p_RS13390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TSH58p_RS13405	COG5001	Diguanylate cyclase
TSH58p_RS13430	COG0583	DNA-binding transcription factor activity
TSH58p_RS13445	COG1024	Enoyl-CoA hydratase
TSH58p_RS13455	COG0601	transmembrane transport
TSH58p_RS13460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_RS13470	COG0625	glutathione transferase activity
TSH58p_RS13475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TSH58p_RS13510	COG0587	DNA-directed DNA polymerase activity
TSH58p_RS13530	COG2358	TRAP transporter, solute receptor (TAXI family
TSH58p_RS13540	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TSH58p_RS13545	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TSH58p_RS13565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TSH58p_RS13575	COG4172	Belongs to the ABC transporter superfamily
TSH58p_RS13580	COG4239	(ABC) transporter, permease
TSH58p_RS13585	COG4174	ABC transporter (Permease)
TSH58p_RS13590	COG4166	transmembrane transport
TSH58p_RS13600	COG4166	transmembrane transport
TSH58p_RS13640	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TSH58p_RS13645	COG3474	cytochrome
TSH58p_RS13660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TSH58p_RS13670	COG0126	phosphoglycerate kinase activity
TSH58p_RS13695	COG4106	trans-aconitate 2-methyltransferase activity
TSH58p_RS13705	COG4191	Histidine kinase
TSH58p_RS13725	COG0596	Alpha beta hydrolase
TSH58p_RS13735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TSH58p_RS13740	COG4974	Belongs to the 'phage' integrase family
TSH58p_RS13750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TSH58p_RS13770	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TSH58p_RS13780	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TSH58p_RS13800	COG1051	belongs to the nudix hydrolase family
TSH58p_RS13810	COG0793	Belongs to the peptidase S41A family
TSH58p_RS13820	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TSH58p_RS13825	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TSH58p_RS13830	COG0799	negative regulation of ribosome biogenesis
TSH58p_RS13845	COG2010	Cytochrome c
TSH58p_RS13845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TSH58p_RS13855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TSH58p_RS13865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TSH58p_RS13870	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TSH58p_RS13875	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TSH58p_RS13915	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TSH58p_RS13940	COG0463	Glycosyl transferase, family 2
TSH58p_RS13950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TSH58p_RS13965	COG0723	plastoquinol--plastocyanin reductase activity
TSH58p_RS13980	COG1131	(ABC) transporter
TSH58p_RS14030	COG1116	anion transmembrane transporter activity
TSH58p_RS14070	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TSH58p_RS14085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TSH58p_RS14090	COG2205	protein histidine kinase activity
TSH58p_RS14090	COG0784	Response regulator, receiver
TSH58p_RS14100	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS14105	COG2766	serine protein kinase
TSH58p_RS14110	COG2718	Belongs to the UPF0229 family
TSH58p_RS14115	COG2719	SpoVR family
TSH58p_RS14130	COG1643	Atp-dependent helicase
TSH58p_RS14135	COG1116	anion transmembrane transporter activity
TSH58p_RS14155	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS14180	COG0330	HflC and HflK could
TSH58p_RS14185	COG0628	permease
TSH58p_RS14200	COG3180	Ammonia monooxygenase
TSH58p_RS14205	COG2988	succinylglutamate desuccinylase activity
TSH58p_RS14245	COG2205	protein histidine kinase activity
TSH58p_RS14245	COG2202	Pas domain
TSH58p_RS14255	COG2205	protein histidine kinase activity
TSH58p_RS14265	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TSH58p_RS14305	COG2197	response regulator
TSH58p_RS14310	COG2197	response regulator
TSH58p_RS14315	COG0210	DNA helicase
TSH58p_RS14330	COG2264	protein methyltransferase activity
TSH58p_RS14340	COG0006	proline dipeptidase activity
TSH58p_RS14340	COG0006	proline dipeptidase activity
TSH58p_RS14345	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS14360	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TSH58p_RS14365	COG0497	DNA recombination
TSH58p_RS14390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TSH58p_RS14405	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TSH58p_RS14410	COG0849	cell division
TSH58p_RS14415	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TSH58p_RS14420	COG1181	Belongs to the D-alanine--D-alanine ligase family
TSH58p_RS14430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TSH58p_RS14435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TSH58p_RS14445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TSH58p_RS14460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TSH58p_RS14470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TSH58p_RS14490	COG2001	Belongs to the MraZ family
TSH58p_RS14505	COG0697	spore germination
TSH58p_RS14510	COG0488	(ABC) transporter
TSH58p_RS14515	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TSH58p_RS14530	COG0277	FAD linked oxidase domain protein
TSH58p_RS14535	COG2084	Dehydrogenase
TSH58p_RS14550	COG0784	Response regulator, receiver
TSH58p_RS14550	COG4191	Histidine kinase
TSH58p_RS14575	COG0142	geranyltranstransferase activity
TSH58p_RS14585	COG2890	protein-(glutamine-N5) methyltransferase activity
TSH58p_RS14605	COG0752	glycyl-tRNA synthetase alpha subunit
TSH58p_RS14610	COG0751	glycine-tRNA ligase activity
TSH58p_RS14615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TSH58p_RS14620	COG1346	cytolysis
TSH58p_RS14625	COG1380	Effector of murein hydrolase LrgA
TSH58p_RS14630	COG1073	alpha beta
TSH58p_RS14660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TSH58p_RS14670	COG2205	protein histidine kinase activity
TSH58p_RS14700	COG3409	Peptidoglycan-binding domain 1 protein
TSH58p_RS14700	COG0860	N-Acetylmuramoyl-L-alanine amidase
TSH58p_RS14705	COG3108	Peptidase M15
TSH58p_RS14720	COG0840	transmembrane signaling receptor activity
TSH58p_RS14735	COG1230	cation diffusion facilitator family transporter
TSH58p_RS14760	COG0511	ligase activity, forming carbon-carbon bonds
TSH58p_RS14765	COG0439	Biotin carboxylase
TSH58p_RS14770	COG3719	Belongs to the RNase T2 family
TSH58p_RS14775	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TSH58p_RS14800	COG1280	lysine exporter protein (LysE YggA)
TSH58p_RS14810	COG1663	tetraacyldisaccharide 4'-kinase activity
TSH58p_RS14815	COG1519	Transferase
TSH58p_RS14835	COG1597	lipid kinase activity
TSH58p_RS14855	COG0312	modulator of DNA gyrase
TSH58p_RS14870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TSH58p_RS14895	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TSH58p_RS14905	COG0436	Aminotransferase
TSH58p_RS14935	COG1530	ribonuclease E activity
TSH58p_RS14945	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TSH58p_RS14985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TSH58p_RS15005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TSH58p_RS15020	COG1309	transcriptional regulator
TSH58p_RS15025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_RS15035	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TSH58p_RS15045	COG0673	inositol 2-dehydrogenase activity
TSH58p_RS15075	COG0411	ABC transporter
TSH58p_RS15085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSH58p_RS15090	COG0840	transmembrane signaling receptor activity
TSH58p_RS15100	COG1940	carbohydrate kinase activity
TSH58p_RS15110	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TSH58p_RS15195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TSH58p_RS15230	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TSH58p_RS15235	COG0081	regulation of translation
TSH58p_RS15240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TSH58p_RS15245	COG0222	ribosome binding
TSH58p_RS15250	COG0085	RNA polymerase activity
TSH58p_RS15255	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TSH58p_RS15270	COG0049	tRNA binding
TSH58p_RS15285	COG0051	transcription antitermination factor activity, RNA binding
TSH58p_RS15295	COG0088	Forms part of the polypeptide exit tunnel
TSH58p_RS15300	COG0089	rRNA binding
TSH58p_RS15305	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TSH58p_RS15310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TSH58p_RS15315	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TSH58p_RS15320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TSH58p_RS15325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TSH58p_RS15330	COG0255	Belongs to the universal ribosomal protein uL29 family
TSH58p_RS15335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TSH58p_RS15345	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TSH58p_RS15355	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TSH58p_RS15360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TSH58p_RS15365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TSH58p_RS15380	COG1841	ribosomal large subunit assembly
TSH58p_RS15385	COG0200	Binds to the 23S rRNA
TSH58p_RS15390	COG0201	protein transport
TSH58p_RS15395	COG0563	adenylate kinase activity
TSH58p_RS15400	COG2186	Transcriptional regulator
TSH58p_RS15415	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TSH58p_RS15430	COG2205	protein histidine kinase activity
TSH58p_RS15435	COG0071	Belongs to the small heat shock protein (HSP20) family
TSH58p_RS15445	COG0254	rRNA binding
TSH58p_RS15450	COG1132	(ABC) transporter
TSH58p_RS15460	COG0500	methyltransferase
TSH58p_RS15485	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TSH58p_RS15520	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TSH58p_RS15530	COG4786	Flagellar basal body rod
TSH58p_RS15535	COG4786	Flagellar basal body rod
TSH58p_RS15575	COG1360	Flagellar Motor Protein
TSH58p_RS15590	COG1338	Plays a role in the flagellum-specific transport system
TSH58p_RS15605	COG2257	FlhB HrpN YscU SpaS Family
TSH58p_RS15610	COG1815	bacterial-type flagellum-dependent cell motility
TSH58p_RS15615	COG1558	bacterial-type flagellum-dependent cell motility
TSH58p_RS15620	COG1677	Flagellar hook-basal body complex protein FliE
TSH58p_RS15625	COG1987	bacterial-type flagellum assembly
TSH58p_RS15630	COG1684	flagellar biosynthetic protein fliR
TSH58p_RS15635	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TSH58p_RS15655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TSH58p_RS15670	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TSH58p_RS15690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TSH58p_RS15720	COG0473	3-isopropylmalate dehydrogenase activity
TSH58p_RS15740	COG3932	Exopolysaccharide synthesis, ExoD
TSH58p_RS15750	COG0538	isocitrate dehydrogenase activity
TSH58p_RS15790	COG0456	acetyltransferase
TSH58p_RS15795	COG2890	protein-(glutamine-N5) methyltransferase activity
TSH58p_RS15800	COG1393	Belongs to the ArsC family
TSH58p_RS15805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TSH58p_RS15815	COG1403	HNH endonuclease
TSH58p_RS15825	COG0505	Belongs to the CarA family
TSH58p_RS15840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TSH58p_RS15870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TSH58p_RS15880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TSH58p_RS15920	COG0251	oxidation-reduction process
TSH58p_RS15925	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TSH58p_RS15935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSH58p_RS15945	COG2205	protein histidine kinase activity
TSH58p_RS15950	COG0628	permease
TSH58p_RS15960	COG0577	efflux transmembrane transporter activity
TSH58p_RS15960	COG1136	(ABC) transporter
TSH58p_RS15965	COG0390	transport system, permease component
TSH58p_RS15975	COG0784	Response regulator, receiver
TSH58p_RS15975	COG5002	protein histidine kinase activity
TSH58p_RS15975	COG2198	Histidine kinase
TSH58p_RS15990	COG0616	signal peptide processing
TSH58p_RS16000	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS16010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TSH58p_RS16020	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TSH58p_RS16025	COG1295	ribonuclease BN
TSH58p_RS16030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TSH58p_RS16045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TSH58p_RS16055	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TSH58p_RS16060	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TSH58p_RS16065	COG0515	serine threonine protein kinase
TSH58p_RS16065	COG3266	domain, Protein
TSH58p_RS16080	COG0564	pseudouridine synthase activity
TSH58p_RS16110	COG0741	lytic transglycosylase activity
TSH58p_RS16120	COG5487	UPF0391 membrane protein
TSH58p_RS16130	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TSH58p_RS16140	COG0312	modulator of DNA gyrase
TSH58p_RS16150	COG1565	acr, cog1565
TSH58p_RS16150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TSH58p_RS16155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TSH58p_RS16160	COG0109	protoheme IX farnesyltransferase activity
TSH58p_RS16170	COG1845	cytochrome c oxidase, subunit III
TSH58p_RS16180	COG3346	SURF1 family
TSH58p_RS16185	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TSH58p_RS16190	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TSH58p_RS16200	COG0612	Peptidase, M16
TSH58p_RS16205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TSH58p_RS16215	COG1678	Uncharacterized ACR, COG1678
TSH58p_RS16225	COG0678	peroxiredoxin activity
TSH58p_RS16230	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_RS16240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TSH58p_RS16250	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TSH58p_RS16270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TSH58p_RS16275	COG0509	glycine decarboxylation via glycine cleavage system
TSH58p_RS16280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TSH58p_RS16285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TSH58p_RS16305	COG0483	inositol monophosphate 1-phosphatase activity
TSH58p_RS16310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TSH58p_RS16315	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TSH58p_RS16320	COG0604	alcohol dehydrogenase
TSH58p_RS16325	COG2067	long-chain fatty acid transport protein
TSH58p_RS16330	COG0730	response to heat
TSH58p_RS16335	COG0352	thiamine-phosphate diphosphorylase activity
TSH58p_RS16340	COG1830	Aldolase
TSH58p_RS16385	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TSH58p_RS16390	COG1692	metallophosphoesterase
TSH58p_RS16395	COG0217	transcriptional regulatory protein
TSH58p_RS16400	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TSH58p_RS16410	COG2255	four-way junction helicase activity
TSH58p_RS16415	COG0824	Thioesterase
TSH58p_RS16425	COG0848	biopolymer transport protein
TSH58p_RS16440	COG2885	chlorophyll binding
TSH58p_RS16455	COG1086	Polysaccharide biosynthesis protein
TSH58p_RS16465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TSH58p_RS16470	COG0438	transferase activity, transferring glycosyl groups
TSH58p_RS16485	COG0367	asparagine synthase
TSH58p_RS16490	COG0697	spore germination
TSH58p_RS16500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TSH58p_RS16510	COG1765	OsmC-like protein
TSH58p_RS16515	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS16520	COG2076	Multidrug Resistance protein
TSH58p_RS16545	COG3437	response regulator, receiver
TSH58p_RS16545	COG0784	Response regulator, receiver
TSH58p_RS16560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_RS16560	COG4191	Histidine kinase
TSH58p_RS16590	COG4520	surface antigen
TSH58p_RS16610	COG0840	transmembrane signaling receptor activity
TSH58p_RS16620	COG1234	tRNA 3'-trailer cleavage
TSH58p_RS16625	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TSH58p_RS16640	COG0523	cobalamin synthesis protein
TSH58p_RS16645	COG0735	belongs to the Fur family
TSH58p_RS16655	COG0415	Belongs to the DNA photolyase family
TSH58p_RS16660	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
TSH58p_RS16670	COG1201	RNA secondary structure unwinding
TSH58p_RS16675	COG2226	methyltransferase
TSH58p_RS16690	COG2267	carboxylic ester hydrolase activity
TSH58p_RS16695	COG1846	Transcriptional regulator
TSH58p_RS16705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_RS16750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TSH58p_RS16755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_RS16760	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_RS16765	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS16770	COG1960	acyl-CoA dehydrogenase activity
TSH58p_RS16785	COG2833	Protein of unknown function (DUF455)
TSH58p_RS16790	COG1218	3'(2'),5'-bisphosphate nucleotidase
TSH58p_RS16810	COG0366	Alpha amylase catalytic
TSH58p_RS16815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TSH58p_RS16825	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS16830	COG1640	4-alpha-glucanotransferase
TSH58p_RS16855	COG5002	protein histidine kinase activity
TSH58p_RS16855	COG2176	DNA-directed DNA polymerase activity
TSH58p_RS16860	COG1671	Belongs to the UPF0178 family
TSH58p_RS16865	COG0488	(ABC) transporter
TSH58p_RS16880	COG2853	Lipoprotein
TSH58p_RS16900	COG0646	methionine synthase
TSH58p_RS16900	COG1410	methionine synthase
TSH58p_RS16915	COG3706	GGDEF domain
TSH58p_RS16920	COG2070	2-Nitropropane dioxygenase
TSH58p_RS16925	COG0243	molybdopterin cofactor binding
TSH58p_RS16940	COG2824	Alkylphosphonate utilization operon protein PhnA
TSH58p_RS16970	COG2205	protein histidine kinase activity
TSH58p_RS16990	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
TSH58p_RS16995	COG1752	Esterase of the alpha-beta hydrolase superfamily
TSH58p_RS17010	COG1773	rubredoxin
TSH58p_RS17020	COG3108	Peptidase M15
TSH58p_RS17035	COG0546	phosphoglycolate phosphatase activity
TSH58p_RS17080	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TSH58p_RS17085	COG2814	Major facilitator Superfamily
TSH58p_RS17090	COG3546	catalase activity
TSH58p_RS17110	COG3411	Ferredoxin
TSH58p_RS17115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TSH58p_RS17125	COG1024	Enoyl-CoA hydratase
TSH58p_RS17135	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TSH58p_RS17195	COG1492	cobalamin metabolic process
TSH58p_RS17200	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TSH58p_RS17220	COG3424	synthase
TSH58p_RS17225	COG1755	Isoprenylcysteine carboxyl methyltransferase
TSH58p_RS17235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_RS17245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_RS17275	COG1217	gtp-binding protein TYPA
TSH58p_RS17295	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TSH58p_RS17305	COG2313	pseudouridylate synthase activity
TSH58p_RS17315	COG1793	dna ligase
TSH58p_RS17325	COG2153	protein acetylation
TSH58p_RS17345	COG3685	Protein conserved in bacteria
TSH58p_RS17365	COG0698	ribose 5-phosphate isomerase
TSH58p_RS17370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TSH58p_RS17375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TSH58p_RS17380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TSH58p_RS17380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TSH58p_RS17390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TSH58p_RS17390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TSH58p_RS17395	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TSH58p_RS17400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TSH58p_RS17405	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TSH58p_RS17415	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TSH58p_RS17435	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TSH58p_RS17440	COG0416	fatty acid biosynthetic process
TSH58p_RS17445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TSH58p_RS17530	COG3723	Recombinational DNA repair protein, rece pathway
TSH58p_RS17585	COG1396	sequence-specific DNA binding
TSH58p_RS17965	COG1216	Glycosyl transferase, family 2
TSH58p_RS17965	COG0438	transferase activity, transferring glycosyl groups
TSH58p_RS17990	COG0297	glycogen (starch) synthase activity
TSH58p_RS18000	COG1216	Glycosyl transferase, family 2
TSH58p_RS18040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_RS18055	COG0784	Response regulator, receiver
TSH58p_RS18055	COG4191	Histidine kinase
TSH58p_RS18090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TSH58p_RS18090	COG4651	solute:proton antiporter activity
TSH58p_RS18100	COG3243	poly(R)-hydroxyalkanoic acid synthase
TSH58p_RS18105	COG3932	Exopolysaccharide synthesis, ExoD
TSH58p_RS18160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TSH58p_RS18180	COG1192	Involved in chromosome partitioning
TSH58p_RS18185	COG1475	DNA binding
TSH58p_RS18195	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TSH58p_RS18210	COG1086	Polysaccharide biosynthesis protein
TSH58p_RS18220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TSH58p_RS18235	COG0494	nUDIX hydrolase
TSH58p_RS18255	COG0528	UMP kinase activity
TSH58p_RS18260	COG0528	UMP kinase activity
TSH58p_RS18285	COG1088	dTDP-glucose 4,6-dehydratase activity
TSH58p_RS18320	COG3436	PFAM IS66 Orf2 family protein
TSH58p_RS18365	COG3328	transposase activity
TSH58p_RS18405	COG0463	Glycosyl transferase, family 2
TSH58p_RS18440	COG0463	Glycosyl transferase, family 2
TSH58p_RS18475	COG0438	transferase activity, transferring glycosyl groups
TSH58p_RS18480	COG0500	methyltransferase
TSH58p_RS18485	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TSH58p_RS18490	COG0579	oxidoreductase
TSH58p_RS18500	COG0297	glycogen (starch) synthase activity
TSH58p_RS18505	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TSH58p_RS18510	COG1088	dTDP-glucose 4,6-dehydratase activity
TSH58p_RS18515	COG1091	dTDP-4-dehydrorhamnose reductase activity
TSH58p_RS18535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSH58p_RS18550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_RS18570	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TSH58p_RS18580	COG0562	UDP-galactopyranose mutase
TSH58p_RS18590	COG1216	Glycosyl transferase, family 2
TSH58p_RS18590	COG0438	transferase activity, transferring glycosyl groups
TSH58p_RS18610	COG0110	maltose O-acetyltransferase activity
TSH58p_RS18670	COG1802	Transcriptional regulator
TSH58p_RS18675	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS18680	COG1917	Cupin 2, conserved barrel domain protein
TSH58p_RS18700	COG0667	Aldo Keto reductase
TSH58p_RS18705	COG1802	Transcriptional regulator
TSH58p_RS18710	COG1803	Methylglyoxal synthase
TSH58p_RS18720	COG1904	glucuronate isomerase
TSH58p_RS18725	COG2721	sulfolactate sulfo-lyase activity
TSH58p_RS18760	COG0861	Integral membrane protein TerC family
TSH58p_RS18795	COG0191	fructose-bisphosphate aldolase activity
TSH58p_RS18800	COG3386	PFAM SMP-30 Gluconolaconase
TSH58p_RS18805	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TSH58p_RS18810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSH58p_RS18865	COG2022	thiamine diphosphate biosynthetic process
TSH58p_RS18875	COG2022	thiamine diphosphate biosynthetic process
TSH58p_RS18875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSH58p_RS18880	COG2239	Acts as a magnesium transporter
TSH58p_RS18905	COG1254	Belongs to the acylphosphatase family
TSH58p_RS18920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TSH58p_RS18925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TSH58p_RS18925	COG2010	Cytochrome c
TSH58p_RS18945	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_RS18950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TSH58p_RS18955	COG2011	ABC-type metal ion transport system permease component
TSH58p_RS18975	COG0246	Mannitol dehydrogenase
TSH58p_RS18980	COG0725	ABC transporter, periplasmic molybdate-binding protein
TSH58p_RS18995	COG5039	Polysaccharide pyruvyl transferase
TSH58p_RS19000	COG2132	Multicopper oxidase
TSH58p_RS19010	COG1309	transcriptional regulator
TSH58p_RS19015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSH58p_RS19020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TSH58p_RS19025	COG0702	epimerase
TSH58p_RS19030	COG1733	regulation of RNA biosynthetic process
TSH58p_RS19040	COG0583	DNA-binding transcription factor activity
TSH58p_RS19055	COG2133	pyrroloquinoline quinone binding
TSH58p_RS19095	COG1312	Catalyzes the dehydration of D-mannonate
TSH58p_RS19100	COG0246	Mannitol dehydrogenase
TSH58p_RS19125	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TSH58p_RS19135	COG0148	phosphopyruvate hydratase activity
TSH58p_RS19145	COG1882	Formate acetyltransferase
TSH58p_RS19150	COG0837	glucose binding
TSH58p_RS19150	COG1737	Transcriptional regulator
TSH58p_RS19165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TSH58p_RS19170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSH58p_RS19175	COG1309	transcriptional regulator
TSH58p_RS19190	COG4251	negative regulation of phosphorylation
TSH58p_RS19195	COG0469	pyruvate kinase activity
TSH58p_RS19200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TSH58p_RS19205	COG2116	formate transmembrane transporter activity
TSH58p_RS19210	COG0697	spore germination
TSH58p_RS19215	COG1802	Transcriptional regulator
TSH58p_RS19220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_RS19230	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_RS19235	COG0861	Integral membrane protein TerC family
TSH58p_RS19265	COG1749	Flagellar hook protein flgE
TSH58p_RS19280	COG1706	bacterial-type flagellum-dependent cell motility
TSH58p_RS19305	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TSH58p_RS19310	COG1684	flagellar biosynthetic protein fliR
TSH58p_RS19315	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TSH58p_RS19325	COG4794	Type iii secretion
TSH58p_RS19330	COG1677	Flagellar hook-basal body complex protein FliE
TSH58p_RS19335	COG1558	bacterial-type flagellum-dependent cell motility
TSH58p_RS19340	COG1815	bacterial-type flagellum-dependent cell motility
TSH58p_RS19360	COG2814	Major facilitator Superfamily
TSH58p_RS19380	COG5443	negative regulation of bacterial-type flagellum assembly
TSH58p_RS19390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TSH58p_RS19415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TSH58p_RS19420	COG1802	Transcriptional regulator
TSH58p_RS19435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TSH58p_RS19440	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TSH58p_RS19445	COG1120	ATPase activity
TSH58p_RS19450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TSH58p_RS19455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TSH58p_RS19465	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TSH58p_RS19475	COG1845	cytochrome c oxidase, subunit III
TSH58p_RS19480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSH58p_RS19490	COG0583	DNA-binding transcription factor activity
TSH58p_RS19500	COG0567	Dehydrogenase, E1 component
TSH58p_RS19505	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSH58p_RS19520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TSH58p_RS19535	COG0277	FAD linked oxidase domain protein
TSH58p_RS19565	COG0154	amidase activity
TSH58p_RS19620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TSH58p_RS19640	COG0683	leucine binding
TSH58p_RS19670	COG3473	Maleate cis-trans isomerase
TSH58p_RS19675	COG0596	Alpha beta hydrolase
TSH58p_RS19680	COG2309	aminopeptidase activity
TSH58p_RS19685	COG1335	isochorismatase
TSH58p_RS19695	COG1609	Transcriptional regulator
TSH58p_RS19700	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TSH58p_RS19700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSH58p_RS19705	COG1105	Belongs to the carbohydrate kinase PfkB family
TSH58p_RS19710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TSH58p_RS19710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TSH58p_RS19720	COG3920	Histidine kinase
TSH58p_RS19725	COG2197	response regulator
TSH58p_RS19755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSH58p_RS19760	COG1473	amidohydrolase
TSH58p_RS19800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TSH58p_RS19805	COG0251	oxidation-reduction process
TSH58p_RS19810	COG1522	sequence-specific DNA binding
TSH58p_RS19820	COG1414	Transcriptional regulator
TSH58p_RS19825	COG0280	phosphate acetyltransferase
TSH58p_RS19845	COG1012	belongs to the aldehyde dehydrogenase family
TSH58p_RS19855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TSH58p_RS19860	COG0243	molybdopterin cofactor binding
TSH58p_RS19865	COG0437	4 iron, 4 sulfur cluster binding
TSH58p_RS19880	COG0028	Belongs to the TPP enzyme family
TSH58p_RS19885	COG1475	DNA binding
TSH58p_RS19890	COG1192	Involved in chromosome partitioning
TSH58p_RS19910	COG0546	phosphoglycolate phosphatase activity
TSH58p_RS19915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TSH58p_RS19915	COG2169	Transcriptional regulator
TSH58p_RS19920	COG2855	membrane
TSH58p_RS19925	COG0583	DNA-binding transcription factor activity
TSH58p_RS19960	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TSH58p_RS19965	COG4191	Histidine kinase
TSH58p_RS19965	COG0784	Response regulator, receiver
TSH58p_RS19990	COG1012	belongs to the aldehyde dehydrogenase family
TSH58p_RS19995	COG0028	Belongs to the TPP enzyme family
TSH58p_RS20000	COG0583	DNA-binding transcription factor activity
TSH58p_RS20010	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS20015	COG0583	DNA-binding transcription factor activity
TSH58p_RS20020	COG0793	Belongs to the peptidase S41A family
TSH58p_RS20025	COG5487	UPF0391 membrane protein
TSH58p_RS20035	COG4191	Histidine kinase
TSH58p_RS20045	COG0028	Belongs to the TPP enzyme family
TSH58p_RS20055	COG1522	sequence-specific DNA binding
TSH58p_RS20080	COG3300	MHYT domain
TSH58p_RS20080	COG5001	Diguanylate cyclase
TSH58p_RS20105	COG2985	domain, Protein
TSH58p_RS20125	COG3842	ATPase activity
TSH58p_RS20135	COG0588	phosphoglycerate mutase activity
TSH58p_RS20150	COG1454	alcohol dehydrogenase
TSH58p_RS20150	COG1012	belongs to the aldehyde dehydrogenase family
TSH58p_RS20235	COG0583	DNA-binding transcription factor activity
TSH58p_RS20260	COG1360	Flagellar Motor Protein
TSH58p_RS20265	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TSH58p_RS20275	COG4786	Flagellar basal body rod
TSH58p_RS20280	COG4786	Flagellar basal body rod
TSH58p_RS20285	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
TSH58p_RS20290	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TSH58p_RS20310	COG0243	molybdopterin cofactor binding
TSH58p_RS20320	COG3005	denitrification pathway
TSH58p_RS20360	COG1766	The M ring may be actively involved in energy transduction
TSH58p_RS20370	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TSH58p_RS20375	COG1338	Plays a role in the flagellum-specific transport system
TSH58p_RS20385	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TSH58p_RS20440	COG3416	Protein conserved in bacteria
TSH58p_RS20445	COG0628	permease
TSH58p_RS20455	COG1597	lipid kinase activity
TSH58p_RS20460	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS20465	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TSH58p_RS20470	COG1802	Transcriptional regulator
TSH58p_RS20490	COG0668	transmembrane transport
TSH58p_RS20540	COG0596	Alpha beta hydrolase
TSH58p_RS20540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TSH58p_RS20540	COG2226	methyltransferase
TSH58p_RS20545	COG0183	Belongs to the thiolase family
TSH58p_RS20550	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS20560	COG2814	Major facilitator Superfamily
TSH58p_RS20565	COG0583	DNA-binding transcription factor activity
TSH58p_RS20575	COG2203	Gaf domain
TSH58p_RS20575	COG5001	Diguanylate cyclase
TSH58p_RS20575	COG3706	GGDEF domain
TSH58p_RS20575	COG4251	negative regulation of phosphorylation
TSH58p_RS20580	COG0012	GTP binding
TSH58p_RS20600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TSH58p_RS20600	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TSH58p_RS20625	COG1131	(ABC) transporter
TSH58p_RS20655	COG3383	formate dehydrogenase (NAD+) activity
TSH58p_RS20660	COG1414	Transcriptional regulator
TSH58p_RS20685	COG4191	Histidine kinase
TSH58p_RS20695	COG0402	S-adenosylhomocysteine deaminase activity
TSH58p_RS20700	COG1079	Belongs to the binding-protein-dependent transport system permease family
TSH58p_RS20705	COG4603	Belongs to the binding-protein-dependent transport system permease family
TSH58p_RS20710	COG3845	ABC transporter
TSH58p_RS20720	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TSH58p_RS20730	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TSH58p_RS20730	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TSH58p_RS20745	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TSH58p_RS20870	COG4964	Belongs to the GSP D family
TSH58p_RS20890	COG1858	cytochrome C peroxidase
TSH58p_RS20920	COG0405	Gamma-glutamyltransferase
TSH58p_RS20940	COG2203	Gaf domain
TSH58p_RS20940	COG2199	diguanylate cyclase activity
TSH58p_RS20950	COG0784	Response regulator, receiver
TSH58p_RS20950	COG4191	Histidine kinase
TSH58p_RS20955	COG1132	(ABC) transporter
TSH58p_RS21025	COG1595	DNA-templated transcription, initiation
TSH58p_RS21040	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS21045	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_RS21055	COG2301	Belongs to the HpcH HpaI aldolase family
TSH58p_RS21065	COG2079	MmgE PrpD family protein
TSH58p_RS21070	COG1960	acyl-CoA dehydrogenase activity
TSH58p_RS21075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSH58p_RS21090	COG0154	amidase activity
TSH58p_RS21105	COG2188	Transcriptional regulator
TSH58p_RS21120	COG0798	PFAM Bile acid sodium symporter
TSH58p_RS21125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_RS21135	COG4166	transmembrane transport
TSH58p_RS21160	COG4251	negative regulation of phosphorylation
TSH58p_RS21165	COG0784	Response regulator, receiver
TSH58p_RS21210	COG1595	DNA-templated transcription, initiation
TSH58p_RS21220	COG1045	serine acetyltransferase
TSH58p_RS21235	COG3842	ATPase activity
TSH58p_RS21240	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_RS21245	COG1178	ABC-type Fe3 transport system permease component
TSH58p_RS21255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TSH58p_RS21260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TSH58p_RS21265	COG2233	PERMEase
TSH58p_RS21275	COG0747	negative chemotaxis
TSH58p_RS21280	COG0601	transmembrane transport
TSH58p_RS21295	COG4608	Belongs to the ABC transporter superfamily
TSH58p_RS21300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSH58p_RS21310	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS21320	COG1744	ABC transporter substrate-binding protein PnrA-like
TSH58p_RS21355	COG0484	heat shock protein binding
TSH58p_RS21365	COG0564	pseudouridine synthase activity
TSH58p_RS21380	COG0156	8-amino-7-oxononanoate synthase activity
TSH58p_RS21390	COG4106	trans-aconitate 2-methyltransferase activity
TSH58p_RS21390	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TSH58p_RS21395	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TSH58p_RS21400	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TSH58p_RS21410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSH58p_RS21410	COG0574	Belongs to the PEP-utilizing enzyme family
TSH58p_RS21415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TSH58p_RS21420	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TSH58p_RS21425	COG1278	Cold shock
TSH58p_RS21430	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_RS21450	COG1496	oxidoreductase activity
TSH58p_RS21460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TSH58p_RS21465	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TSH58p_RS21475	COG1172	Belongs to the binding-protein-dependent transport system permease family
TSH58p_RS21480	COG1172	Belongs to the binding-protein-dependent transport system permease family
TSH58p_RS21485	COG1129	ABC transporter
TSH58p_RS21490	COG1879	ABC-type sugar transport system periplasmic component
TSH58p_RS21525	COG4214	carbohydrate transport
TSH58p_RS21535	COG0129	dihydroxy-acid dehydratase activity
TSH58p_RS21550	COG1802	Transcriptional regulator
TSH58p_RS21555	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS21560	COG1917	Cupin 2, conserved barrel domain protein
TSH58p_RS21565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_RS21580	COG0667	Aldo Keto reductase
TSH58p_RS21585	COG1802	Transcriptional regulator
TSH58p_RS21605	COG2721	sulfolactate sulfo-lyase activity
TSH58p_RS21650	COG2204	response regulator
TSH58p_RS21660	COG0569	domain protein
TSH58p_RS21675	COG1923	regulation of RNA biosynthetic process
TSH58p_RS21680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TSH58p_RS21695	COG0483	inositol monophosphate 1-phosphatase activity
TSH58p_RS21710	COG3956	TIGRFAM MazG family protein
TSH58p_RS21715	COG3260	NADH ubiquinone oxidoreductase 20
TSH58p_RS21720	COG0649	NAD binding
TSH58p_RS21725	COG0651	ATP synthesis coupled electron transport
TSH58p_RS21735	COG0650	Formate hydrogenlyase subunit 4
TSH58p_RS21740	COG0651	ATP synthesis coupled electron transport
TSH58p_RS21750	COG2183	response to ionizing radiation
TSH58p_RS21760	COG1280	lysine exporter protein (LysE YggA)
TSH58p_RS21790	COG0393	Putative heavy-metal-binding
TSH58p_RS21795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TSH58p_RS21810	COG4166	transmembrane transport
TSH58p_RS21815	COG0625	glutathione transferase activity
TSH58p_RS21820	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSH58p_RS21825	COG0366	Alpha amylase catalytic
TSH58p_RS21850	COG0840	transmembrane signaling receptor activity
TSH58p_RS21885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TSH58p_RS21895	COG0583	DNA-binding transcription factor activity
TSH58p_RS21900	COG4336	lyase activity
TSH58p_RS21925	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TSH58p_RS21930	COG1984	allophanate hydrolase subunit 2
TSH58p_RS21935	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TSH58p_RS21950	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TSH58p_RS21955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TSH58p_RS21960	COG0058	SHG alpha-glucan phosphorylase activity
TSH58p_RS21970	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TSH58p_RS22005	COG5002	protein histidine kinase activity
TSH58p_RS22010	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS22040	COG1959	2 iron, 2 sulfur cluster binding
TSH58p_RS22045	COG0719	Fe-S assembly protein
TSH58p_RS22050	COG0396	ATPase activity
TSH58p_RS22055	COG0719	Fe-S assembly protein
TSH58p_RS22060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TSH58p_RS22065	COG0822	iron-sulfur transferase activity
TSH58p_RS22070	COG0489	protein tyrosine kinase activity
TSH58p_RS22075	COG0316	Belongs to the HesB IscA family
TSH58p_RS22095	COG0308	aminopeptidase N
TSH58p_RS22115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TSH58p_RS22150	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TSH58p_RS22155	COG0697	spore germination
TSH58p_RS22165	COG2814	Major facilitator Superfamily
TSH58p_RS22170	COG0583	DNA-binding transcription factor activity
TSH58p_RS22185	COG3383	formate dehydrogenase (NAD+) activity
TSH58p_RS22190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TSH58p_RS22205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSH58p_RS22210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSH58p_RS22230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TSH58p_RS22240	COG0129	dihydroxy-acid dehydratase activity
TSH58p_RS22255	COG3920	Histidine kinase
TSH58p_RS22280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TSH58p_RS22285	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TSH58p_RS22290	COG0534	Mate efflux family protein
TSH58p_RS22335	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TSH58p_RS22375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TSH58p_RS22490	COG4974	Belongs to the 'phage' integrase family
TSH58p_RS22495	COG0629	single-stranded DNA binding
TSH58p_RS22500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TSH58p_RS22530	COG1562	ergosterol biosynthetic process
TSH58p_RS22535	COG1562	ergosterol biosynthetic process
TSH58p_RS22540	COG1233	COG1233 Phytoene dehydrogenase and related
TSH58p_RS22550	COG3737	Protein of unknown function (DUF498/DUF598)
TSH58p_RS22560	COG1862	Preprotein translocase
TSH58p_RS22580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TSH58p_RS22590	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TSH58p_RS22600	COG0805	protein transport
TSH58p_RS22605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TSH58p_RS22610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TSH58p_RS22615	COG3842	ATPase activity
TSH58p_RS22620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TSH58p_RS22625	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TSH58p_RS22630	COG1994	Peptidase M50
TSH58p_RS22635	COG1472	Belongs to the glycosyl hydrolase 3 family
TSH58p_RS22650	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TSH58p_RS22655	COG0316	Belongs to the HesB IscA family
TSH58p_RS22660	COG0708	Exodeoxyribonuclease III
TSH58p_RS22745	COG0464	growth
TSH58p_RS22760	COG3772	lysozyme
TSH58p_RS22955	COG0519	Catalyzes the synthesis of GMP from XMP
TSH58p_RS22960	COG1247	-acetyltransferase
TSH58p_RS22975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TSH58p_RS22975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TSH58p_RS22995	COG3813	Protein conserved in bacteria
TSH58p_RS23000	COG0357	Ribosomal RNA small subunit methyltransferase G
TSH58p_RS23000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TSH58p_RS23030	COG0066	3-isopropylmalate dehydratase activity
TSH58p_RS23035	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TSH58p_RS23040	COG1053	succinate dehydrogenase
TSH58p_RS23045	COG1335	isochorismatase
TSH58p_RS23090	COG0683	leucine binding
TSH58p_RS23095	COG2188	Transcriptional regulator
TSH58p_RS23140	COG0784	Response regulator, receiver
TSH58p_RS23140	COG5002	protein histidine kinase activity
TSH58p_RS23140	COG2198	Histidine kinase
TSH58p_RS23160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TSH58p_RS23165	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
TSH58p_RS23185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_RS23190	COG0601	transmembrane transport
TSH58p_RS23210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSH58p_RS23215	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
TSH58p_RS23220	COG1301	dicarboxylic acid transport
TSH58p_RS23225	COG2828	Protein conserved in bacteria
TSH58p_RS23230	COG0583	DNA-binding transcription factor activity
TSH58p_RS23240	COG1472	Belongs to the glycosyl hydrolase 3 family
TSH58p_RS23250	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS23255	COG5002	protein histidine kinase activity
TSH58p_RS23260	COG2204	response regulator
TSH58p_RS23265	COG3852	Histidine kinase
TSH58p_RS23270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_RS23315	COG0270	DNA (cytosine-5-)-methyltransferase activity
TSH58p_RS23340	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TSH58p_RS23395	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TSH58p_RS23555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TSH58p_RS23575	COG4771	TonB-dependent receptor
TSH58p_RS23580	COG0477	Major facilitator Superfamily
TSH58p_RS23595	COG1169	isochorismate synthase
TSH58p_RS23600	COG1021	2,3-dihydroxybenzoate-AMP ligase
TSH58p_RS23605	COG3433	isochorismatase activity
TSH58p_RS23605	COG1535	isochorismatase
TSH58p_RS23610	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS23620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TSH58p_RS23625	COG2382	esterase
TSH58p_RS23635	COG1595	DNA-templated transcription, initiation
TSH58p_RS23645	COG1882	Formate acetyltransferase
TSH58p_RS23655	COG3008	intermembrane lipid transfer
TSH58p_RS23655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TSH58p_RS23660	COG2995	paraquat-inducible protein a
TSH58p_RS23670	COG0457	Tetratricopeptide repeat
TSH58p_RS23670	COG0859	PFAM glycosyl transferase family 9
TSH58p_RS23675	COG0280	phosphate acetyltransferase
TSH58p_RS23675	COG0281	malic enzyme
TSH58p_RS23680	COG1301	dicarboxylic acid transport
TSH58p_RS23685	COG4191	Histidine kinase
TSH58p_RS23690	COG2204	response regulator
TSH58p_RS23700	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSH58p_RS23700	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSH58p_RS23705	COG1268	BioY protein
TSH58p_RS23710	COG4770	biotin carboxylase activity
TSH58p_RS23715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TSH58p_RS23725	COG1794	racemase activity, acting on amino acids and derivatives
TSH58p_RS23740	COG1012	belongs to the aldehyde dehydrogenase family
TSH58p_RS23750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSH58p_RS23755	COG0431	NADPH-dependent FMN reductase
TSH58p_RS23755	COG1053	succinate dehydrogenase
TSH58p_RS23755	COG3976	FMN-binding domain protein
TSH58p_RS23775	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_RS23790	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS23795	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS23800	COG4251	negative regulation of phosphorylation
TSH58p_RS23810	COG1733	regulation of RNA biosynthetic process
TSH58p_RS23835	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TSH58p_RS23845	COG1846	Transcriptional regulator
TSH58p_RS23875	COG0644	oxidoreductase
TSH58p_RS23900	COG3547	Transposase (IS116 IS110 IS902 family)
TSH58p_RS23930	COG3436	PFAM IS66 Orf2 family protein
TSH58p_RS23955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TSH58p_RS23990	COG3335	DDE superfamily endonuclease
TSH58p_RS23995	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TSH58p_RS24005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TSH58p_RS24025	COG0425	Belongs to the sulfur carrier protein TusA family
TSH58p_RS24035	COG0640	Transcriptional regulator
TSH58p_RS24055	COG2857	Cytochrome c1
TSH58p_RS24055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TSH58p_RS24070	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TSH58p_RS24075	COG0408	coproporphyrinogen oxidase activity
TSH58p_RS24080	COG0617	tRNA 3'-terminal CCA addition
TSH58p_RS24100	COG0714	Associated with various cellular activities
TSH58p_RS24145	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS24150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TSH58p_RS24210	COG2099	Precorrin-6x reductase
TSH58p_RS24240	COG1797	cobyrinic acid a,c-diamide synthase activity
TSH58p_RS24245	COG0778	Nitroreductase
TSH58p_RS24250	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS24255	COG1309	transcriptional regulator
TSH58p_RS24260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TSH58p_RS24265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSH58p_RS24270	COG0737	Belongs to the 5'-nucleotidase family
TSH58p_RS24295	COG1749	Flagellar hook protein flgE
TSH58p_RS24295	COG1749	Flagellar hook protein flgE
TSH58p_RS24320	COG0795	lipopolysaccharide-transporting ATPase activity
TSH58p_RS24325	COG0840	transmembrane signaling receptor activity
TSH58p_RS24330	COG1137	ATPase activity
TSH58p_RS24390	COG2723	6-phospho-beta-galactosidase activity
TSH58p_RS24405	COG2086	electron transfer activity
TSH58p_RS24415	COG1250	3-hydroxyacyl-CoA dehydrogenase
TSH58p_RS24425	COG1073	alpha beta
TSH58p_RS24430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TSH58p_RS24445	COG0019	diaminopimelate decarboxylase activity
TSH58p_RS24470	COG0772	Belongs to the SEDS family
TSH58p_RS24480	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS24500	COG1253	flavin adenine dinucleotide binding
TSH58p_RS24510	COG2205	protein histidine kinase activity
TSH58p_RS24525	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
TSH58p_RS24545	COG1657	PFAM Prenyltransferase squalene oxidase
TSH58p_RS24570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_RS24605	COG1741	Belongs to the pirin family
TSH58p_RS24610	COG2860	membrane
TSH58p_RS24620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TSH58p_RS24625	COG0789	Transcriptional regulator
TSH58p_RS24640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TSH58p_RS24645	COG4520	surface antigen
TSH58p_RS24685	COG1566	PFAM secretion protein HlyD family protein
TSH58p_RS24695	COG0583	DNA-binding transcription factor activity
TSH58p_RS24700	COG2814	Major facilitator Superfamily
TSH58p_RS24705	COG0656	L-ascorbic acid biosynthetic process
TSH58p_RS24710	COG0471	metal ion transport
TSH58p_RS24710	COG3273	potassium ion transport
TSH58p_RS24740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSH58p_RS24750	COG0583	DNA-binding transcription factor activity
TSH58p_RS24755	COG3842	ATPase activity
TSH58p_RS24760	COG2182	Extracellular solute-binding protein
TSH58p_RS24765	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_RS24775	COG1396	sequence-specific DNA binding
TSH58p_RS24775	COG1917	Cupin 2, conserved barrel domain protein
TSH58p_RS24785	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TSH58p_RS24795	COG5507	3-demethylubiquinone-9 3-methyltransferase
TSH58p_RS24810	COG1309	transcriptional regulator
TSH58p_RS24835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TSH58p_RS24845	COG1522	sequence-specific DNA binding
TSH58p_RS24850	COG1192	Involved in chromosome partitioning
TSH58p_RS24880	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
TSH58p_RS24885	COG1530	ribonuclease E activity
TSH58p_RS24895	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TSH58p_RS24910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TSH58p_RS24920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TSH58p_RS24965	COG0588	phosphoglycerate mutase activity
TSH58p_RS24975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TSH58p_RS24985	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
TSH58p_RS24995	COG3693	PFAM glycoside hydrolase, family 10
TSH58p_RS25005	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TSH58p_RS25025	COG1215	transferase activity, transferring glycosyl groups
TSH58p_RS25030	COG0438	transferase activity, transferring glycosyl groups
TSH58p_RS25035	COG0438	transferase activity, transferring glycosyl groups
TSH58p_RS25055	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_RS25060	COG0367	asparagine synthase
TSH58p_RS25065	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TSH58p_RS25110	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TSH58p_RS25115	COG4208	sulfate ABC transporter
TSH58p_RS25125	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TSH58p_RS25135	COG1959	2 iron, 2 sulfur cluster binding
TSH58p_RS25140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TSH58p_RS25165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_RS25190	COG1573	uracil-dna glycosylase
TSH58p_RS25195	COG0741	lytic transglycosylase activity
TSH58p_RS25200	COG0521	Mo-molybdopterin cofactor biosynthetic process
TSH58p_RS25235	COG0297	glycogen (starch) synthase activity
TSH58p_RS25275	COG1960	acyl-CoA dehydrogenase activity
TSH58p_RS25285	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
TSH58p_RS25295	COG0583	DNA-binding transcription factor activity
TSH58p_RS25300	COG2080	2 iron, 2 sulfur cluster binding
TSH58p_RS25305	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TSH58p_RS25310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TSH58p_RS25330	COG2900	Belongs to the SlyX family
TSH58p_RS25375	COG4520	surface antigen
TSH58p_RS25435	COG3328	transposase activity
TSH58p_RS25470	COG1201	RNA secondary structure unwinding
TSH58p_RS25525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TSH58p_RS25530	COG1063	alcohol dehydrogenase
TSH58p_RS25535	COG4948	Mandelate Racemase Muconate Lactonizing
TSH58p_RS25540	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS25560	COG0583	DNA-binding transcription factor activity
TSH58p_RS25650	COG0420	3'-5' exonuclease activity
TSH58p_RS25660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSH58p_RS25670	COG1192	Involved in chromosome partitioning
TSH58p_RS25675	COG1475	DNA binding
TSH58p_RS25690	COG3707	response regulator
TSH58p_RS25695	COG1116	anion transmembrane transporter activity
TSH58p_RS25705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TSH58p_RS25710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TSH58p_RS25715	COG2146	nitrite reductase [NAD(P)H] activity
TSH58p_RS25720	COG0243	molybdopterin cofactor binding
TSH58p_RS25725	COG1648	precorrin-2 dehydrogenase activity
TSH58p_RS25725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TSH58p_RS25740	COG1032	radical SAM domain protein
TSH58p_RS25790	COG1609	Transcriptional regulator
TSH58p_RS25795	COG0583	DNA-binding transcription factor activity
TSH58p_RS25810	COG3195	allantoin biosynthetic process
TSH58p_RS25810	COG3648	Uricase
TSH58p_RS25820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSH58p_RS25845	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TSH58p_RS25890	COG0243	molybdopterin cofactor binding
TSH58p_RS25890	COG3383	formate dehydrogenase (NAD+) activity
TSH58p_RS25895	COG0437	4 iron, 4 sulfur cluster binding
TSH58p_RS25900	COG2864	formate dehydrogenase
TSH58p_RS25905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSH58p_RS25930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_RS25940	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS25995	COG2223	nitrite transmembrane transporter activity
TSH58p_RS26030	COG1137	ATPase activity
TSH58p_RS26035	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TSH58p_RS26040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TSH58p_RS26045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TSH58p_RS26050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TSH58p_RS26055	COG0527	aspartate kinase activity
TSH58p_RS26075	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TSH58p_RS26080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TSH58p_RS26090	COG2852	Protein conserved in bacteria
TSH58p_RS26095	COG2890	protein-(glutamine-N5) methyltransferase activity
TSH58p_RS26115	COG0542	response to heat
TSH58p_RS26120	COG1272	protein, Hemolysin III
TSH58p_RS26130	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TSH58p_RS26145	COG0840	transmembrane signaling receptor activity
TSH58p_RS26150	COG5265	(ABC) transporter
TSH58p_RS26160	COG1703	isobutyryl-CoA mutase activity
TSH58p_RS26170	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TSH58p_RS26180	COG2137	regulation of response to DNA damage stimulus
TSH58p_RS26185	COG0842	Transport permease protein
TSH58p_RS26190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TSH58p_RS26195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TSH58p_RS26210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TSH58p_RS26215	COG0671	phosphoesterase, PA-phosphatase related
TSH58p_RS26230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TSH58p_RS26235	COG4774	siderophore transport
TSH58p_RS26240	COG3128	pkhd-type hydroxylase
TSH58p_RS26255	COG4604	ABC transporter, ATP-binding protein
TSH58p_RS26260	COG4605	iron ion homeostasis
TSH58p_RS26265	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TSH58p_RS26270	COG4607	ABC-type enterochelin transport system periplasmic component
TSH58p_RS26275	COG1695	Transcriptional regulator
TSH58p_RS26315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TSH58p_RS26315	COG1116	anion transmembrane transporter activity
TSH58p_RS26390	COG4206	TonB-dependent receptor
TSH58p_RS26430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TSH58p_RS26435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TSH58p_RS26435	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TSH58p_RS26440	COG1660	Displays ATPase and GTPase activities
TSH58p_RS26445	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TSH58p_RS26455	COG0642	Histidine kinase
TSH58p_RS26460	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS26475	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TSH58p_RS26490	COG0739	heme binding
TSH58p_RS26530	COG1942	4-Oxalocrotonate Tautomerase
TSH58p_RS26535	COG0235	Class ii aldolase
TSH58p_RS26555	COG0243	molybdopterin cofactor binding
TSH58p_RS26555	COG3383	formate dehydrogenase (NAD+) activity
TSH58p_RS26560	COG0437	4 iron, 4 sulfur cluster binding
TSH58p_RS26565	COG2864	formate dehydrogenase
TSH58p_RS26570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TSH58p_RS26580	COG2205	protein histidine kinase activity
TSH58p_RS26585	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS26600	COG0840	transmembrane signaling receptor activity
TSH58p_RS26610	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TSH58p_RS26620	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TSH58p_RS26640	COG1073	alpha beta
TSH58p_RS26640	COG2226	methyltransferase
TSH58p_RS26650	COG2027	D-alanyl-D-alanine carboxypeptidase
TSH58p_RS26660	COG2091	lysine biosynthetic process via aminoadipic acid
TSH58p_RS26665	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TSH58p_RS26670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TSH58p_RS26680	COG2111	Na H antiporter
TSH58p_RS26680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TSH58p_RS26685	COG1006	Multisubunit Na H antiporter MnhC subunit
TSH58p_RS26690	COG0651	ATP synthesis coupled electron transport
TSH58p_RS26695	COG1863	multisubunit Na H antiporter MnhE subunit
TSH58p_RS26700	COG2212	antiporter activity
TSH58p_RS26705	COG1320	monovalent cation:proton antiporter activity
TSH58p_RS26745	COG4615	Cyclic peptide transporter
TSH58p_RS26780	COG0683	leucine binding
TSH58p_RS26805	COG3842	ATPase activity
TSH58p_RS26815	COG1175	transmembrane transport
TSH58p_RS26835	COG1024	Enoyl-CoA hydratase
TSH58p_RS26850	COG4221	oxidoreductase activity
TSH58p_RS26855	COG1609	Transcriptional regulator
TSH58p_RS26885	COG1966	Carbon starvation protein
TSH58p_RS26890	COG2879	small protein
TSH58p_RS26905	COG4221	oxidoreductase activity
TSH58p_RS26915	COG2186	Transcriptional regulator
TSH58p_RS26925	COG0765	amino acid transport
TSH58p_RS26930	COG0765	amino acid transport
TSH58p_RS26965	COG0840	transmembrane signaling receptor activity
TSH58p_RS26970	COG2423	ornithine cyclodeaminase activity
TSH58p_RS26975	COG0657	acetylesterase activity
TSH58p_RS27010	COG2814	Major facilitator Superfamily
TSH58p_RS27015	COG0583	DNA-binding transcription factor activity
TSH58p_RS27020	COG0747	negative chemotaxis
TSH58p_RS27025	COG0601	transmembrane transport
TSH58p_RS27040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSH58p_RS27045	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_RS27050	COG3842	ATPase activity
TSH58p_RS27060	COG0277	FAD linked oxidase domain protein
TSH58p_RS27075	COG3685	Protein conserved in bacteria
TSH58p_RS27105	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TSH58p_RS27110	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSH58p_RS27130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TSH58p_RS27185	COG4566	intracellular signal transduction
TSH58p_RS27190	COG4191	Histidine kinase
TSH58p_RS27195	COG1335	isochorismatase
TSH58p_RS27260	COG0625	glutathione transferase activity
TSH58p_RS27265	COG0583	DNA-binding transcription factor activity
TSH58p_RS27270	COG4948	Mandelate Racemase Muconate Lactonizing
TSH58p_RS27285	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TSH58p_RS27300	COG0583	DNA-binding transcription factor activity
TSH58p_RS27310	COG1283	sodium-dependent phosphate transmembrane transporter activity
TSH58p_RS27370	COG0306	phosphate transporter
TSH58p_RS27375	COG1392	Phosphate transport regulator
TSH58p_RS27385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TSH58p_RS27390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TSH58p_RS27405	COG0716	FMN binding
TSH58p_RS27410	COG2223	nitrite transmembrane transporter activity
TSH58p_RS27440	COG0612	Peptidase, M16
TSH58p_RS27450	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
TSH58p_RS27465	COG0409	Hydrogenase expression formation protein
TSH58p_RS27470	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSH58p_RS27480	COG0488	(ABC) transporter
TSH58p_RS27495	COG2249	NAD(P)H dehydrogenase (quinone) activity
TSH58p_RS27510	COG0586	Pfam SNARE associated Golgi protein
TSH58p_RS27540	COG2884	Cell division ATP-binding protein ftsE
TSH58p_RS27575	COG5001	Diguanylate cyclase
TSH58p_RS27580	COG1381	Involved in DNA repair and RecF pathway recombination
TSH58p_RS27585	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TSH58p_RS27590	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSH58p_RS27595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_RS27595	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TSH58p_RS27615	COG2308	Evidence 4 Homologs of previously reported genes of
TSH58p_RS27620	COG1360	Flagellar Motor Protein
TSH58p_RS27630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TSH58p_RS27655	COG0643	Histidine kinase
TSH58p_RS27655	COG0784	Response regulator, receiver
TSH58p_RS27655	COG2198	Histidine kinase
TSH58p_RS27660	COG0835	chemotaxis
TSH58p_RS27665	COG2198	Histidine kinase
TSH58p_RS27665	COG0784	Response regulator, receiver
TSH58p_RS27665	COG0643	Histidine kinase
TSH58p_RS27680	COG0583	DNA-binding transcription factor activity
TSH58p_RS27690	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS27705	COG5001	Diguanylate cyclase
TSH58p_RS27705	COG3300	MHYT domain
TSH58p_RS27725	COG0552	protein localization to endoplasmic reticulum
TSH58p_RS27730	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TSH58p_RS27735	COG2204	response regulator
TSH58p_RS27740	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TSH58p_RS27745	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TSH58p_RS27755	COG1766	The M ring may be actively involved in energy transduction
TSH58p_RS27760	COG1396	sequence-specific DNA binding
TSH58p_RS27800	COG1686	Belongs to the peptidase S11 family
TSH58p_RS27815	COG1840	ABC-type Fe3 transport system, periplasmic component
TSH58p_RS27820	COG4149	molybdate abc transporter
TSH58p_RS27825	COG3842	ATPase activity
TSH58p_RS27840	COG2391	methyltransferase activity
TSH58p_RS27850	COG0583	DNA-binding transcription factor activity
TSH58p_RS27855	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
TSH58p_RS27860	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
TSH58p_RS27865	COG2358	TRAP transporter, solute receptor (TAXI family
TSH58p_RS27885	COG0246	Mannitol dehydrogenase
TSH58p_RS27890	COG2721	sulfolactate sulfo-lyase activity
TSH58p_RS27895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_RS27905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_RS27910	COG1063	alcohol dehydrogenase
TSH58p_RS27955	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
TSH58p_RS27955	COG3264	Mechanosensitive ion channel
TSH58p_RS27970	COG0386	Belongs to the glutathione peroxidase family
TSH58p_RS27990	COG0837	glucose binding
TSH58p_RS27990	COG1737	Transcriptional regulator
TSH58p_RS27995	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TSH58p_RS28000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_RS28005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_RS28015	COG0179	Fumarylacetoacetate (FAA) hydrolase
TSH58p_RS28030	COG0436	Aminotransferase
TSH58p_RS28035	COG2205	protein histidine kinase activity
TSH58p_RS28035	COG2202	Pas domain
TSH58p_RS28040	COG2373	Large extracellular alpha-helical protein
TSH58p_RS28060	COG1250	3-hydroxyacyl-CoA dehydrogenase
TSH58p_RS28060	COG1024	Enoyl-CoA hydratase
TSH58p_RS28065	COG1960	acyl-CoA dehydrogenase activity
TSH58p_RS28080	COG3047	cAMP biosynthetic process
TSH58p_RS28095	COG1196	nuclear chromosome segregation
TSH58p_RS28110	COG1194	a g-specific adenine glycosylase
TSH58p_RS28130	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TSH58p_RS28140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TSH58p_RS28140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_RS28145	COG3012	SEC-C Motif Domain Protein
TSH58p_RS28150	COG1278	Cold shock
TSH58p_RS28155	COG0793	Belongs to the peptidase S41A family
TSH58p_RS28175	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TSH58p_RS28185	COG0375	protein maturation
TSH58p_RS28200	COG0298	carbon dioxide binding
TSH58p_RS28225	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TSH58p_RS28230	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TSH58p_RS28235	COG5557	Pfam Polysulphide reductase, NrfD
TSH58p_RS28240	COG0437	4 iron, 4 sulfur cluster binding
TSH58p_RS28245	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
TSH58p_RS28260	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TSH58p_RS28285	COG4178	(ABC) transporter
TSH58p_RS28295	COG0625	glutathione transferase activity
TSH58p_RS28320	COG1640	4-alpha-glucanotransferase
TSH58p_RS28340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSH58p_RS28355	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS28360	COG2205	protein histidine kinase activity
TSH58p_RS28360	COG2198	Histidine kinase
TSH58p_RS28360	COG0784	Response regulator, receiver
TSH58p_RS28365	COG1278	Cold shock
TSH58p_RS28375	COG1846	Transcriptional regulator
TSH58p_RS28380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TSH58p_RS28385	COG0556	nucleotide-excision repair
TSH58p_RS28405	COG2205	protein histidine kinase activity
TSH58p_RS28410	COG2927	DNA polymerase III (CHI subunit)
TSH58p_RS28415	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TSH58p_RS28445	COG0741	lytic transglycosylase activity
TSH58p_RS28460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TSH58p_RS28470	COG1561	YicC-like family, N-terminal region
TSH58p_RS28475	COG0300	oxidoreductase activity
TSH58p_RS28480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TSH58p_RS28485	COG3932	Exopolysaccharide synthesis, ExoD
TSH58p_RS28490	COG0488	(ABC) transporter
TSH58p_RS28495	COG0105	UTP biosynthetic process
TSH58p_RS28510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TSH58p_RS28515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TSH58p_RS28525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TSH58p_RS28530	COG0628	permease
TSH58p_RS28540	COG0300	oxidoreductase activity
TSH58p_RS28545	COG3025	triphosphatase activity
TSH58p_RS28555	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TSH58p_RS28560	COG0248	Ppx GppA phosphatase
TSH58p_RS28570	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TSH58p_RS28575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TSH58p_RS28595	COG5001	Diguanylate cyclase
TSH58p_RS28595	COG5002	protein histidine kinase activity
TSH58p_RS28595	COG3447	MASE1 domain protein
TSH58p_RS28600	COG2202	Pas domain
TSH58p_RS28600	COG2205	protein histidine kinase activity
TSH58p_RS28605	COG0784	Response regulator, receiver
TSH58p_RS28615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TSH58p_RS28620	COG0793	Belongs to the peptidase S41A family
TSH58p_RS28625	COG0557	exoribonuclease II activity
TSH58p_RS28640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TSH58p_RS28645	COG0758	DNA mediated transformation
TSH58p_RS28665	COG2814	Major facilitator Superfamily
TSH58p_RS28700	COG2205	protein histidine kinase activity
TSH58p_RS28700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_RS28705	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS28740	COG0581	inorganic phosphate transmembrane transporter activity
TSH58p_RS28755	COG3842	ATPase activity
TSH58p_RS28765	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TSH58p_RS28770	COG1732	Glycine betaine
TSH58p_RS28775	COG1174	glycine betaine transport
TSH58p_RS28780	COG1125	glycine betaine transport
TSH58p_RS28785	COG1174	glycine betaine transport
TSH58p_RS28795	COG1652	LysM domain
TSH58p_RS28800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSH58p_RS28810	COG1024	Enoyl-CoA hydratase
TSH58p_RS28815	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TSH58p_RS28820	COG1609	Transcriptional regulator
TSH58p_RS28825	COG3265	gluconokinase activity
TSH58p_RS28835	COG3971	2-oxopent-4-enoate hydratase activity
TSH58p_RS28840	COG1609	Transcriptional regulator
TSH58p_RS28845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TSH58p_RS28850	COG1126	abc transporter atp-binding protein
TSH58p_RS28855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_RS28860	COG0765	amino acid transport
TSH58p_RS28865	COG0765	amino acid transport
TSH58p_RS28870	COG0303	'Molybdopterin
TSH58p_RS28890	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS28895	COG0730	response to heat
TSH58p_RS28910	COG0717	Belongs to the dCTP deaminase family
TSH58p_RS28920	COG0625	glutathione transferase activity
TSH58p_RS28925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TSH58p_RS28945	COG2813	Specifically methylates the guanine in position
TSH58p_RS28945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TSH58p_RS28950	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TSH58p_RS28960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TSH58p_RS28965	COG0287	Prephenate dehydrogenase
TSH58p_RS28970	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TSH58p_RS28980	COG0583	DNA-binding transcription factor activity
TSH58p_RS28990	COG3634	alkyl hydroperoxide reductase activity
TSH58p_RS28995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TSH58p_RS29000	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TSH58p_RS29005	COG2080	2 iron, 2 sulfur cluster binding
TSH58p_RS29015	COG1988	membrane-bound metal-dependent
TSH58p_RS29035	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS29045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TSH58p_RS29050	COG0540	Belongs to the ATCase OTCase family
TSH58p_RS29065	COG0583	DNA-binding transcription factor activity
TSH58p_RS29090	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TSH58p_RS29100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TSH58p_RS29105	COG0154	amidase activity
TSH58p_RS29110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TSH58p_RS29150	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TSH58p_RS29155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_RS29165	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
TSH58p_RS29170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TSH58p_RS29180	COG0657	acetylesterase activity
TSH58p_RS29195	COG0667	Aldo Keto reductase
TSH58p_RS29205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TSH58p_RS29255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TSH58p_RS29260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TSH58p_RS29265	COG1127	ABC transporter
TSH58p_RS29285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TSH58p_RS29290	COG1271	oxidase subunit
TSH58p_RS29295	COG1294	oxidase, subunit
TSH58p_RS29325	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS29350	COG2089	acid synthase
TSH58p_RS29355	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
TSH58p_RS29385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TSH58p_RS29390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TSH58p_RS29405	COG0457	Tetratricopeptide repeat
TSH58p_RS29405	COG0859	PFAM glycosyl transferase family 9
TSH58p_RS29415	COG0859	PFAM glycosyl transferase family 9
TSH58p_RS29415	COG0457	Tetratricopeptide repeat
TSH58p_RS29465	COG0784	Response regulator, receiver
TSH58p_RS29490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TSH58p_RS29500	COG1228	amidohydrolase
TSH58p_RS29505	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TSH58p_RS29520	COG2226	methyltransferase
TSH58p_RS29530	COG0747	negative chemotaxis
TSH58p_RS29535	COG0601	transmembrane transport
TSH58p_RS29540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_RS29545	COG0444	Belongs to the ABC transporter superfamily
TSH58p_RS29550	COG4608	Belongs to the ABC transporter superfamily
TSH58p_RS29585	COG1666	GTP binding
TSH58p_RS29610	COG5001	Diguanylate cyclase
TSH58p_RS29640	COG1752	Esterase of the alpha-beta hydrolase superfamily
TSH58p_RS29645	COG1132	(ABC) transporter
TSH58p_RS29650	COG4191	Histidine kinase
TSH58p_RS29675	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TSH58p_RS29685	COG2264	protein methyltransferase activity
TSH58p_RS29690	COG0583	DNA-binding transcription factor activity
TSH58p_RS29695	COG0655	NAD(P)H dehydrogenase (quinone) activity
TSH58p_RS29700	COG0435	Glutathione S-transferase
TSH58p_RS29710	COG2197	response regulator
TSH58p_RS29720	COG0492	ferredoxin-NADP+ reductase activity
TSH58p_RS29750	COG0484	heat shock protein binding
TSH58p_RS29755	COG0501	Belongs to the peptidase M48B family
TSH58p_RS29765	COG3038	cytochrome b561
TSH58p_RS29785	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TSH58p_RS29795	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TSH58p_RS29805	COG1846	Transcriptional regulator
TSH58p_RS29815	COG3920	Histidine kinase
TSH58p_RS29830	COG1758	RNA polymerase activity
TSH58p_RS29845	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TSH58p_RS29850	COG0736	holo-[acyl-carrier-protein] synthase activity
TSH58p_RS29855	COG0681	Belongs to the peptidase S26 family
TSH58p_RS29860	COG0571	ribonuclease III activity
TSH58p_RS29865	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TSH58p_RS29870	COG3106	COG3106 Predicted ATPase
TSH58p_RS29875	COG3768	UPF0283 membrane protein
TSH58p_RS29895	COG0740	serine-type endopeptidase activity
TSH58p_RS29900	COG1215	transferase activity, transferring glycosyl groups
TSH58p_RS29905	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TSH58p_RS29910	COG1566	PFAM secretion protein HlyD family protein
TSH58p_RS29915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TSH58p_RS29925	COG2307	Protein conserved in bacteria
TSH58p_RS29925	COG2308	Evidence 4 Homologs of previously reported genes of
TSH58p_RS29945	COG2017	converts alpha-aldose to the beta-anomer
TSH58p_RS29950	COG0515	serine threonine protein kinase
TSH58p_RS29950	COG2815	serine threonine protein kinase
TSH58p_RS29985	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TSH58p_RS29995	COG0513	Belongs to the DEAD box helicase family
TSH58p_RS30020	COG0187	DNA topoisomerase II activity
TSH58p_RS30025	COG1607	acyl-coa hydrolase
TSH58p_RS30030	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TSH58p_RS30035	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TSH58p_RS30040	COG0022	dehydrogenase e1 component
TSH58p_RS30040	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSH58p_RS30045	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSH58p_RS30050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TSH58p_RS30055	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TSH58p_RS30060	COG2867	negative regulation of translational initiation
TSH58p_RS30100	COG2204	response regulator
TSH58p_RS30255	COG0582	viral genome integration into host DNA
TSH58p_RS30365	COG1120	ATPase activity
TSH58p_RS30385	COG2271	Major facilitator Superfamily
TSH58p_RS30390	COG0583	DNA-binding transcription factor activity
TSH58p_RS30420	COG4774	siderophore transport
TSH58p_RS30425	COG1120	ATPase activity
TSH58p_RS30435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TSH58p_RS30440	COG1132	(ABC) transporter
TSH58p_RS30450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_RS30465	COG0826	peptidase U32
TSH58p_RS30490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TSH58p_RS30505	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
TSH58p_RS30520	COG4263	nitrous-oxide reductase activity
TSH58p_RS30540	COG0714	Associated with various cellular activities
TSH58p_RS30545	COG3256	nitric oxide reductase
TSH58p_RS30555	COG2897	thiosulfate sulfurtransferase activity
TSH58p_RS30620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSH58p_RS30630	COG0446	pyridine nucleotide-disulphide oxidoreductase
TSH58p_RS30630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TSH58p_RS30650	COG2072	flavoprotein involved in K transport
TSH58p_RS30655	COG2301	Belongs to the HpcH HpaI aldolase family
TSH58p_RS30665	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS30670	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TSH58p_RS30670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_RS30680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_RS30685	COG0022	dehydrogenase e1 component
TSH58p_RS30690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TSH58p_RS30695	COG1396	sequence-specific DNA binding
TSH58p_RS30700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_RS30705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TSH58p_RS30715	COG0459	protein refolding
TSH58p_RS30720	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TSH58p_RS30735	COG1464	Belongs to the NlpA lipoprotein family
TSH58p_RS30740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TSH58p_RS30745	COG2011	ABC-type metal ion transport system permease component
TSH58p_RS30755	COG1574	metal-dependent hydrolase with the TIM-barrel fold
TSH58p_RS30760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_RS30765	COG1116	anion transmembrane transporter activity
TSH58p_RS30780	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TSH58p_RS30805	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS30830	COG3842	ATPase activity
TSH58p_RS30835	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_RS30840	COG1177	transmembrane transport
TSH58p_RS30855	COG1396	sequence-specific DNA binding
TSH58p_RS30855	COG1917	Cupin 2, conserved barrel domain protein
TSH58p_RS30865	COG1335	isochorismatase
TSH58p_RS30870	COG0583	DNA-binding transcription factor activity
TSH58p_RS30875	COG1982	Orn Lys Arg decarboxylase major
TSH58p_RS30880	COG0697	spore germination
TSH58p_RS30885	COG4608	Belongs to the ABC transporter superfamily
TSH58p_RS30890	COG0444	Belongs to the ABC transporter superfamily
TSH58p_RS30895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_RS30900	COG0601	transmembrane transport
TSH58p_RS30910	COG0747	negative chemotaxis
TSH58p_RS30915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TSH58p_RS30920	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TSH58p_RS30930	COG4608	Belongs to the ABC transporter superfamily
TSH58p_RS30935	COG0444	Belongs to the ABC transporter superfamily
TSH58p_RS30940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_RS30950	COG4948	Mandelate Racemase Muconate Lactonizing
TSH58p_RS30955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TSH58p_RS30965	COG3181	Tripartite tricarboxylate transporter family receptor
TSH58p_RS30970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TSH58p_RS31010	COG0765	amino acid transport
TSH58p_RS31045	COG2175	clavaminate synthase activity
TSH58p_RS31050	COG1116	anion transmembrane transporter activity
TSH58p_RS31055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_RS31065	COG2175	clavaminate synthase activity
TSH58p_RS31075	COG4521	taurine ABC transporter
TSH58p_RS31080	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TSH58p_RS31085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_RS31090	COG3119	arylsulfatase activity
TSH58p_RS31095	COG2175	clavaminate synthase activity
TSH58p_RS31100	COG2084	Dehydrogenase
TSH58p_RS31110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_RS31115	COG3958	Transketolase
TSH58p_RS31120	COG3959	Transketolase, thiamine diphosphate binding domain
TSH58p_RS31125	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS31130	COG0583	DNA-binding transcription factor activity
TSH58p_RS31145	COG4772	TonB-dependent receptor
TSH58p_RS31160	COG2201	protein-glutamate methylesterase activity
TSH58p_RS31165	COG0784	Response regulator, receiver
TSH58p_RS31165	COG2205	protein histidine kinase activity
TSH58p_RS31165	COG5002	protein histidine kinase activity
TSH58p_RS31170	COG0747	negative chemotaxis
TSH58p_RS31175	COG2186	Transcriptional regulator
TSH58p_RS31180	COG1024	Enoyl-CoA hydratase
TSH58p_RS31185	COG1012	belongs to the aldehyde dehydrogenase family
TSH58p_RS31205	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_RS31210	COG1566	PFAM secretion protein HlyD family protein
TSH58p_RS31225	COG2207	Transcriptional regulator
TSH58p_RS31240	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS31250	COG3712	iron ion homeostasis
TSH58p_RS31275	COG0583	DNA-binding transcription factor activity
TSH58p_RS31285	COG0747	negative chemotaxis
TSH58p_RS31295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_RS31305	COG0251	oxidation-reduction process
TSH58p_RS31315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSH58p_RS31340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TSH58p_RS31370	COG3107	peptidoglycan biosynthetic process
TSH58p_RS31405	COG3920	Histidine kinase
TSH58p_RS31435	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_RS31440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TSH58p_RS31465	COG0071	Belongs to the small heat shock protein (HSP20) family
TSH58p_RS31475	COG2249	NAD(P)H dehydrogenase (quinone) activity
TSH58p_RS31480	COG0574	Belongs to the PEP-utilizing enzyme family
TSH58p_RS31480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSH58p_RS31490	COG1136	(ABC) transporter
TSH58p_RS31490	COG0577	efflux transmembrane transporter activity
TSH58p_RS31495	COG0577	efflux transmembrane transporter activity
TSH58p_RS31495	COG1136	(ABC) transporter
TSH58p_RS31515	COG0667	Aldo Keto reductase
TSH58p_RS31525	COG1192	Involved in chromosome partitioning
TSH58p_RS31530	COG1475	DNA binding
TSH58p_RS31540	COG4626	Terminase
TSH58p_RS31540	COG1802	Transcriptional regulator
TSH58p_RS31570	COG4774	siderophore transport
TSH58p_RS31580	COG1595	DNA-templated transcription, initiation
TSH58p_RS31600	COG0765	amino acid transport
TSH58p_RS31610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSH58p_RS31620	COG1126	abc transporter atp-binding protein
TSH58p_RS31630	COG1070	Carbohydrate kinase
TSH58p_RS31635	COG2115	Belongs to the xylose isomerase family
TSH58p_RS31640	COG0673	inositol 2-dehydrogenase activity
TSH58p_RS31650	COG1879	ABC-type sugar transport system periplasmic component
TSH58p_RS31655	COG1172	Belongs to the binding-protein-dependent transport system permease family
TSH58p_RS31665	COG1940	carbohydrate kinase activity
TSH58p_RS31670	COG0251	oxidation-reduction process
TSH58p_RS31675	COG0583	DNA-binding transcription factor activity
TSH58p_RS31720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TSH58p_RS31725	COG0402	S-adenosylhomocysteine deaminase activity
TSH58p_RS31740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TSH58p_RS31750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSH58p_RS31760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSH58p_RS31765	COG1129	ABC transporter
TSH58p_RS31765	COG0842	Transport permease protein
TSH58p_RS31770	COG0842	Transport permease protein
TSH58p_RS31780	COG3721	Heme iron utilization protein
TSH58p_RS31790	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS31795	COG1120	ATPase activity
TSH58p_RS31800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TSH58p_RS31810	COG3720	iron ion transport
TSH58p_RS31820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TSH58p_RS31845	COG0583	DNA-binding transcription factor activity
TSH58p_RS31855	COG1017	nitric oxide dioxygenase activity
TSH58p_RS31855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TSH58p_RS31860	COG0625	glutathione transferase activity
TSH58p_RS31865	COG1802	Transcriptional regulator
TSH58p_RS31870	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TSH58p_RS31875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TSH58p_RS31880	COG1234	tRNA 3'-trailer cleavage
TSH58p_RS31885	COG1177	transmembrane transport
TSH58p_RS31900	COG3842	ATPase activity
TSH58p_RS31920	COG2197	response regulator
TSH58p_RS31925	COG0840	transmembrane signaling receptor activity
TSH58p_RS31940	COG3842	ATPase activity
TSH58p_RS31945	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_RS31950	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_RS31955	COG3938	Belongs to the proline racemase family
TSH58p_RS31960	COG1802	Transcriptional regulator
TSH58p_RS31965	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TSH58p_RS31970	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TSH58p_RS31975	COG0066	3-isopropylmalate dehydratase activity
TSH58p_RS31990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_RS32050	COG3842	ATPase activity
TSH58p_RS32055	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
TSH58p_RS32060	COG1349	DNA-binding transcription factor activity
TSH58p_RS32075	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS32090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_RS32100	COG1024	Enoyl-CoA hydratase
TSH58p_RS32105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSH58p_RS32110	COG0154	amidase activity
TSH58p_RS32120	COG2188	Transcriptional regulator
TSH58p_RS32145	COG1757	Na H antiporter
TSH58p_RS32205	COG0714	Associated with various cellular activities
TSH58p_RS32240	COG2205	protein histidine kinase activity
TSH58p_RS32250	COG2205	protein histidine kinase activity
TSH58p_RS32250	COG0784	Response regulator, receiver
TSH58p_RS32270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TSH58p_RS32290	COG3328	transposase activity
TSH58p_RS32305	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TSH58p_RS32310	COG1454	alcohol dehydrogenase
TSH58p_RS32315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSH58p_RS32325	COG1116	anion transmembrane transporter activity
TSH58p_RS32330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_RS32360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TSH58p_RS32365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSH58p_RS32370	COG0697	spore germination
TSH58p_RS32380	COG1609	Transcriptional regulator
TSH58p_RS32390	COG2188	Transcriptional regulator
TSH58p_RS32415	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
TSH58p_RS32460	COG3250	beta-galactosidase activity
TSH58p_RS32465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_RS32470	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_RS32470	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TSH58p_RS32485	COG0861	Integral membrane protein TerC family
TSH58p_RS32490	COG0251	oxidation-reduction process
TSH58p_RS32500	COG0251	oxidation-reduction process
TSH58p_RS32505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSH58p_RS32525	COG1177	transmembrane transport
TSH58p_RS32530	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_RS32535	COG3842	ATPase activity
TSH58p_RS32550	COG1126	abc transporter atp-binding protein
TSH58p_RS32555	COG0765	amino acid transport
TSH58p_RS32570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSH58p_RS32580	COG0277	FAD linked oxidase domain protein
TSH58p_RS32585	COG1396	sequence-specific DNA binding
TSH58p_RS32635	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_RS32640	COG3246	L-lysine catabolic process to acetate
TSH58p_RS32645	COG1250	3-hydroxyacyl-CoA dehydrogenase
TSH58p_RS32650	COG2204	response regulator
TSH58p_RS32665	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TSH58p_RS32670	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TSH58p_RS32675	COG1278	Cold shock
TSH58p_RS32685	COG0745	RESPONSE REGULATOR receiver
TSH58p_RS32685	COG4566	intracellular signal transduction
TSH58p_RS32700	COG0411	ABC transporter
TSH58p_RS32715	COG0683	leucine binding
TSH58p_RS32720	COG2814	Major facilitator Superfamily
TSH58p_RS32730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TSH58p_RS32735	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TSH58p_RS32765	COG0633	Ferredoxin
TSH58p_RS32770	COG2124	cytochrome p450
TSH58p_RS32785	COG0583	DNA-binding transcription factor activity
TSH58p_RS32795	COG1595	DNA-templated transcription, initiation
TSH58p_RS32800	COG4774	siderophore transport
TSH58p_RS32815	COG4774	siderophore transport