locus-tag	class	description
GCU53_RS00010	COG2944	sequence-specific DNA binding
GCU53_RS00080	COG2197	response regulator
GCU53_RS00115	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GCU53_RS00135	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GCU53_RS00145	COG1475	DNA binding
GCU53_RS00165	COG3039	Transposase
GCU53_RS00190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GCU53_RS00205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GCU53_RS00205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCU53_RS00210	COG2814	Major facilitator Superfamily
GCU53_RS00215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCU53_RS00220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GCU53_RS00235	COG3299	homolog of phage Mu protein gp47
GCU53_RS00310	COG1815	bacterial-type flagellum-dependent cell motility
GCU53_RS00315	COG1558	bacterial-type flagellum-dependent cell motility
GCU53_RS00320	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GCU53_RS00325	COG1749	Flagellar hook protein flgE
GCU53_RS00330	COG4787	bacterial-type flagellum-dependent cell motility
GCU53_RS00340	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GCU53_RS00345	COG1706	bacterial-type flagellum-dependent cell motility
GCU53_RS00390	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GCU53_RS00420	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GCU53_RS00430	COG1677	Flagellar hook-basal body complex protein FliE
GCU53_RS00435	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GCU53_RS00455	COG2257	FlhB HrpN YscU SpaS Family
GCU53_RS00480	COG2198	Histidine kinase
GCU53_RS00480	COG0643	Histidine kinase
GCU53_RS00485	COG0835	chemotaxis
GCU53_RS00490	COG0840	transmembrane signaling receptor activity
GCU53_RS00495	COG0840	transmembrane signaling receptor activity
GCU53_RS00500	COG0840	transmembrane signaling receptor activity
GCU53_RS00510	COG2201	protein-glutamate methylesterase activity
GCU53_RS00515	COG0840	transmembrane signaling receptor activity
GCU53_RS00520	COG0745	RESPONSE REGULATOR receiver
GCU53_RS00525	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GCU53_RS00530	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GCU53_RS00535	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GCU53_RS00555	COG1191	sigma factor activity
GCU53_RS00560	COG3437	response regulator, receiver
GCU53_RS00565	COG1334	flagellar protein FlaG
GCU53_RS00640	COG2816	NAD+ diphosphatase activity
GCU53_RS00655	COG0616	signal peptide processing
GCU53_RS00670	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GCU53_RS00680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GCU53_RS00700	COG2706	6-phosphogluconolactonase activity
GCU53_RS00705	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GCU53_RS00715	COG3265	gluconokinase activity
GCU53_RS00720	COG1609	Transcriptional regulator
GCU53_RS00730	COG1737	Transcriptional regulator
GCU53_RS00740	COG0800	Aldolase
GCU53_RS00745	COG0469	pyruvate kinase activity
GCU53_RS00750	COG0148	phosphopyruvate hydratase activity
GCU53_RS00765	COG4580	involved in the transport of maltose and maltodextrins
GCU53_RS00770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GCU53_RS00785	COG1136	(ABC) transporter
GCU53_RS00785	COG0577	efflux transmembrane transporter activity
GCU53_RS00840	COG1611	Belongs to the LOG family
GCU53_RS00865	COG0492	ferredoxin-NADP+ reductase activity
GCU53_RS00895	COG0483	inositol monophosphate 1-phosphatase activity
GCU53_RS00915	COG3039	Transposase
GCU53_RS00945	COG1012	belongs to the aldehyde dehydrogenase family
GCU53_RS00950	COG2721	sulfolactate sulfo-lyase activity
GCU53_RS01010	COG1454	alcohol dehydrogenase
GCU53_RS01075	COG0523	cobalamin synthesis protein
GCU53_RS01090	COG3284	Transcriptional regulator
GCU53_RS01100	COG3039	Transposase
GCU53_RS01105	COG0145	ligase activity
GCU53_RS01110	COG4647	ligase activity
GCU53_RS01115	COG0145	ligase activity
GCU53_RS01120	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
GCU53_RS01130	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GCU53_RS01150	COG0183	Belongs to the thiolase family
GCU53_RS01165	COG0583	DNA-binding transcription factor activity
GCU53_RS01175	COG2271	Major facilitator Superfamily
GCU53_RS01180	COG0679	Auxin Efflux Carrier
GCU53_RS01190	COG0583	DNA-binding transcription factor activity
GCU53_RS01225	COG0246	Mannitol dehydrogenase
GCU53_RS01230	COG4977	sequence-specific DNA binding
GCU53_RS01230	COG1917	Cupin 2, conserved barrel domain protein
GCU53_RS01235	COG3604	Transcriptional regulator
GCU53_RS01245	COG1012	belongs to the aldehyde dehydrogenase family
GCU53_RS01280	COG0149	triose-phosphate isomerase activity
GCU53_RS01285	COG0469	pyruvate kinase activity
GCU53_RS01290	COG3039	Transposase
GCU53_RS01315	COG3622	Belongs to the hyi family
GCU53_RS01320	COG0235	Class ii aldolase
GCU53_RS01325	COG3395	kinase activity
GCU53_RS01330	COG2084	Dehydrogenase
GCU53_RS01335	COG2186	Transcriptional regulator
GCU53_RS01340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCU53_RS01360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GCU53_RS01370	COG1609	Transcriptional regulator
GCU53_RS01400	COG1064	alcohol dehydrogenase
GCU53_RS01410	COG2814	Major facilitator Superfamily
GCU53_RS01425	COG0402	S-adenosylhomocysteine deaminase activity
GCU53_RS01430	COG2986	histidine ammonia-lyase
GCU53_RS01485	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GCU53_RS01535	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GCU53_RS01540	COG1760	l-serine dehydratase
GCU53_RS01545	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GCU53_RS01545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GCU53_RS01560	COG0701	Predicted permease
GCU53_RS01570	COG0798	PFAM Bile acid sodium symporter
GCU53_RS01575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GCU53_RS01580	COG0640	Transcriptional regulator
GCU53_RS01585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GCU53_RS01590	COG0431	NADPH-dependent FMN reductase
GCU53_RS01600	COG1742	UPF0060 membrane protein
GCU53_RS01605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GCU53_RS01615	COG2217	Heavy metal translocating P-type atpase
GCU53_RS01650	COG1368	sulfuric ester hydrolase activity
GCU53_RS01660	COG0583	DNA-binding transcription factor activity
GCU53_RS01665	COG0667	Aldo Keto reductase
GCU53_RS01675	COG2010	Cytochrome c
GCU53_RS01675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GCU53_RS01700	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GCU53_RS01705	COG0589	response to stress
GCU53_RS01710	COG0459	protein refolding
GCU53_RS01715	COG0071	Belongs to the small heat shock protein (HSP20) family
GCU53_RS01720	COG0543	2 iron, 2 sulfur cluster binding
GCU53_RS01720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GCU53_RS01740	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GCU53_RS01760	COG0183	Belongs to the thiolase family
GCU53_RS01765	COG1960	acyl-CoA dehydrogenase activity
GCU53_RS01775	COG0069	glutamate synthase activity
GCU53_RS01790	COG1752	Esterase of the alpha-beta hydrolase superfamily
GCU53_RS01790	COG1752	Esterase of the alpha-beta hydrolase superfamily
GCU53_RS01795	COG1309	transcriptional regulator
GCU53_RS01800	COG4566	intracellular signal transduction
GCU53_RS01805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GCU53_RS01820	COG1309	transcriptional regulator
GCU53_RS01850	COG2226	methyltransferase
GCU53_RS01860	COG0573	inorganic phosphate transmembrane transporter activity
GCU53_RS01865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GCU53_RS01900	COG4191	Histidine kinase
GCU53_RS01905	COG0318	PFAM AMP-dependent synthetase and ligase
GCU53_RS01915	COG1250	3-hydroxyacyl-CoA dehydrogenase
GCU53_RS01920	COG1960	acyl-CoA dehydrogenase activity
GCU53_RS01955	COG0322	excinuclease ABC activity
GCU53_RS01970	COG2847	Copper chaperone PCu(A)C
GCU53_RS01980	COG0659	secondary active sulfate transmembrane transporter activity
GCU53_RS01990	COG0297	glycogen (starch) synthase activity
GCU53_RS01995	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GCU53_RS02000	COG1640	4-alpha-glucanotransferase
GCU53_RS02020	COG0517	IMP dehydrogenase activity
GCU53_RS02035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GCU53_RS02040	COG0392	lysyltransferase activity
GCU53_RS02050	COG0604	alcohol dehydrogenase
GCU53_RS02055	COG0583	DNA-binding transcription factor activity
GCU53_RS02070	COG3158	transport of potassium into the cell
GCU53_RS02080	COG3046	protein related to deoxyribodipyrimidine photolyase
GCU53_RS02110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GCU53_RS02115	COG0366	Alpha amylase catalytic
GCU53_RS02145	COG2920	part of a sulfur-relay system
GCU53_RS02150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GCU53_RS02155	COG1648	precorrin-2 dehydrogenase activity
GCU53_RS02155	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GCU53_RS02160	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GCU53_RS02165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GCU53_RS02170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GCU53_RS02175	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GCU53_RS02185	COG0492	ferredoxin-NADP+ reductase activity
GCU53_RS02190	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GCU53_RS02195	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GCU53_RS02200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GCU53_RS02205	COG0542	response to heat
GCU53_RS02210	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GCU53_RS02215	COG1278	Cold shock
GCU53_RS02230	COG0482	sulfurtransferase activity
GCU53_RS02235	COG2915	High frequency lysogenization protein hflD homolog
GCU53_RS02245	COG2850	peptidyl-arginine hydroxylation
GCU53_RS02250	COG2153	protein acetylation
GCU53_RS02270	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCU53_RS02275	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCU53_RS02280	COG0649	NAD binding
GCU53_RS02280	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCU53_RS02300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GCU53_RS02305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCU53_RS02315	COG0713	ATP synthesis coupled electron transport
GCU53_RS02330	COG1007	ATP synthesis coupled electron transport
GCU53_RS02350	COG0720	synthase
GCU53_RS02355	COG0741	lytic transglycosylase activity
GCU53_RS02365	COG1459	type II secretion system
GCU53_RS02380	COG2135	peptidase activity
GCU53_RS02390	COG0488	(ABC) transporter
GCU53_RS02400	COG1278	Cold shock
GCU53_RS02405	COG1968	undecaprenyl-diphosphatase activity
GCU53_RS02420	COG0316	Belongs to the HesB IscA family
GCU53_RS02420	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GCU53_RS02430	COG1538	Outer membrane efflux protein
GCU53_RS02450	COG1115	amino acid carrier protein
GCU53_RS02455	COG2911	Protein conserved in bacteria
GCU53_RS02460	COG0729	surface antigen
GCU53_RS02485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GCU53_RS02505	COG3039	Transposase
GCU53_RS02510	COG3039	Transposase
GCU53_RS02515	COG3039	Transposase
GCU53_RS02520	COG1621	beta-fructofuranosidase activity
GCU53_RS02525	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GCU53_RS02530	COG1028	Short-chain dehydrogenase reductase Sdr
GCU53_RS02560	COG0784	Response regulator, receiver
GCU53_RS02560	COG2205	protein histidine kinase activity
GCU53_RS02560	COG5002	protein histidine kinase activity
GCU53_RS02565	COG3039	Transposase
GCU53_RS02575	COG3039	Transposase
GCU53_RS02585	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GCU53_RS02595	COG4191	Histidine kinase
GCU53_RS02605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GCU53_RS02615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GCU53_RS02630	COG2165	general secretion pathway protein
GCU53_RS02670	COG0745	RESPONSE REGULATOR receiver
GCU53_RS02685	COG1234	tRNA 3'-trailer cleavage
GCU53_RS02745	COG0322	excinuclease ABC activity
GCU53_RS02750	COG4702	Belongs to the UPF0303 family
GCU53_RS02770	COG2999	glutathione oxidoreductase activity
GCU53_RS02780	COG0513	Belongs to the DEAD box helicase family
GCU53_RS02795	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GCU53_RS02810	COG0500	methyltransferase
GCU53_RS02820	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GCU53_RS02825	COG0297	glycogen (starch) synthase activity
GCU53_RS02845	COG0577	efflux transmembrane transporter activity
GCU53_RS02845	COG1136	(ABC) transporter
GCU53_RS02880	COG0328	RNA-DNA hybrid ribonuclease activity
GCU53_RS02895	COG1388	LysM domain
GCU53_RS02895	COG0741	lytic transglycosylase activity
GCU53_RS02910	COG4174	ABC transporter (Permease)
GCU53_RS02915	COG4239	(ABC) transporter, permease
GCU53_RS02920	COG4172	Belongs to the ABC transporter superfamily
GCU53_RS02930	COG0697	spore germination
GCU53_RS02945	COG0045	succinate-CoA ligase (ADP-forming) activity
GCU53_RS02975	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GCU53_RS02980	COG2009	succinate dehydrogenase
GCU53_RS03005	COG3123	guanosine phosphorylase activity
GCU53_RS03015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GCU53_RS03025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GCU53_RS03035	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GCU53_RS03040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCU53_RS03045	COG1132	(ABC) transporter
GCU53_RS03050	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GCU53_RS03075	COG0438	transferase activity, transferring glycosyl groups
GCU53_RS03080	COG0438	transferase activity, transferring glycosyl groups
GCU53_RS03100	COG0438	transferase activity, transferring glycosyl groups
GCU53_RS03105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GCU53_RS03120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GCU53_RS03125	COG0463	Glycosyl transferase, family 2
GCU53_RS03175	COG1216	Glycosyl transferase, family 2
GCU53_RS03180	COG1442	glycosyl transferase family 8
GCU53_RS03180	COG1216	Glycosyl transferase, family 2
GCU53_RS03185	COG1442	glycosyl transferase family 8
GCU53_RS03185	COG1216	Glycosyl transferase, family 2
GCU53_RS03200	COG2186	Transcriptional regulator
GCU53_RS03205	COG0277	FAD linked oxidase domain protein
GCU53_RS03210	COG0277	FAD linked oxidase domain protein
GCU53_RS03215	COG0247	lactate metabolic process
GCU53_RS03220	COG3193	protein, possibly involved in utilization of glycolate and propanediol
GCU53_RS03225	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GCU53_RS03230	COG0318	PFAM AMP-dependent synthetase and ligase
GCU53_RS03240	COG2030	dehydratase
GCU53_RS03245	COG0402	S-adenosylhomocysteine deaminase activity
GCU53_RS03255	COG0673	inositol 2-dehydrogenase activity
GCU53_RS03285	COG3181	Tripartite tricarboxylate transporter family receptor
GCU53_RS03295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GCU53_RS03300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GCU53_RS03305	COG3115	cell septum assembly
GCU53_RS03320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GCU53_RS03325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GCU53_RS03355	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GCU53_RS03425	COG1116	anion transmembrane transporter activity
GCU53_RS03430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GCU53_RS03435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GCU53_RS03440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GCU53_RS03445	COG0431	NADPH-dependent FMN reductase
GCU53_RS03450	COG0450	alkyl hydroperoxide reductase
GCU53_RS03455	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GCU53_RS03490	COG4221	oxidoreductase activity
GCU53_RS03495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GCU53_RS03500	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GCU53_RS03510	COG2175	clavaminate synthase activity
GCU53_RS03520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCU53_RS03530	COG0583	DNA-binding transcription factor activity
GCU53_RS03575	COG1960	acyl-CoA dehydrogenase activity
GCU53_RS03590	COG1116	anion transmembrane transporter activity
GCU53_RS03590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GCU53_RS03595	COG1929	Belongs to the glycerate kinase type-1 family
GCU53_RS03640	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GCU53_RS03655	COG1028	Short-chain dehydrogenase reductase Sdr
GCU53_RS03665	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GCU53_RS03710	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GCU53_RS03745	COG1136	(ABC) transporter
GCU53_RS03745	COG0577	efflux transmembrane transporter activity
GCU53_RS03750	COG0778	Nitroreductase
GCU53_RS03765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GCU53_RS03780	COG0235	Class ii aldolase
GCU53_RS03790	COG3293	Transposase
GCU53_RS03810	COG1902	pentaerythritol trinitrate reductase activity
GCU53_RS03815	COG0640	Transcriptional regulator
GCU53_RS03825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GCU53_RS03830	COG2814	Major facilitator Superfamily
GCU53_RS03835	COG0583	DNA-binding transcription factor activity
GCU53_RS03840	COG1335	isochorismatase
GCU53_RS03870	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GCU53_RS03875	COG2011	ABC-type metal ion transport system permease component
GCU53_RS03890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GCU53_RS03910	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GCU53_RS03920	COG4208	sulfate ABC transporter
GCU53_RS03930	COG3781	membrane
GCU53_RS03965	COG2433	Pfam Transposase IS66
GCU53_RS03970	COG3436	PFAM IS66 Orf2 family protein
GCU53_RS04030	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
GCU53_RS04095	COG4118	positive regulation of growth
GCU53_RS04200	COG3039	Transposase
GCU53_RS04230	COG2026	Addiction module toxin, RelE StbE family
GCU53_RS04250	COG3941	tape measure
GCU53_RS04280	COG0616	signal peptide processing
GCU53_RS04340	COG4197	protein conserved in bacteria, prophage-related
GCU53_RS04415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GCU53_RS04420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GCU53_RS04430	COG0745	RESPONSE REGULATOR receiver
GCU53_RS04435	COG2853	Lipoprotein
GCU53_RS04470	COG0514	ATP-dependent DNA helicase (RecQ)
GCU53_RS04480	COG2832	Protein of unknown function (DUF454)
GCU53_RS04490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GCU53_RS04505	COG0121	glutamine amidotransferase
GCU53_RS04520	COG1295	ribonuclease BN
GCU53_RS04535	COG2983	Belongs to the UPF0260 family
GCU53_RS04565	COG3100	YcgL domain-containing protein
GCU53_RS04595	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GCU53_RS04605	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GCU53_RS04620	COG1492	cobalamin metabolic process
GCU53_RS04630	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GCU53_RS04635	COG0778	Nitroreductase
GCU53_RS04640	COG1797	cobyrinic acid a,c-diamide synthase activity
GCU53_RS04655	COG4206	TonB-dependent receptor
GCU53_RS04660	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GCU53_RS04665	COG0505	Belongs to the CarA family
GCU53_RS04670	COG2258	MOSC domain
GCU53_RS04675	COG0791	NLP P60 protein
GCU53_RS04680	COG0791	NLP P60 protein
GCU53_RS04695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GCU53_RS04705	COG0037	tRNA processing
GCU53_RS04720	COG3091	SprT-like family
GCU53_RS04735	COG2977	Belongs to the P-Pant transferase superfamily
GCU53_RS04745	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GCU53_RS04755	COG3039	Transposase
GCU53_RS04760	COG1943	Transposase
GCU53_RS04765	COG2226	methyltransferase
GCU53_RS04815	COG0826	peptidase U32
GCU53_RS04830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GCU53_RS04835	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GCU53_RS04900	COG2274	protein secretion by the type I secretion system
GCU53_RS04905	COG0217	transcriptional regulatory protein
GCU53_RS04940	COG2824	Alkylphosphonate utilization operon protein PhnA
GCU53_RS04945	COG3416	Protein conserved in bacteria
GCU53_RS04975	COG2358	TRAP transporter, solute receptor (TAXI family
GCU53_RS04980	COG0477	Major facilitator Superfamily
GCU53_RS04990	COG4191	Histidine kinase
GCU53_RS04995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GCU53_RS05000	COG1403	HNH endonuclease
GCU53_RS05050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GCU53_RS05055	COG3002	Belongs to the UPF0753 family
GCU53_RS05065	COG4067	protein conserved in archaea
GCU53_RS05065	COG0189	ligase activity
GCU53_RS05090	COG0745	RESPONSE REGULATOR receiver
GCU53_RS05100	COG0642	Histidine kinase
GCU53_RS05110	COG3642	lipopolysaccharide core region biosynthetic process
GCU53_RS05130	COG0738	Major facilitator superfamily
GCU53_RS05135	COG0166	Belongs to the GPI family
GCU53_RS05160	COG2610	gluconate transmembrane transporter activity
GCU53_RS05165	COG1028	Short-chain dehydrogenase reductase Sdr
GCU53_RS05170	COG2031	fatty acid transporter
GCU53_RS05185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GCU53_RS05210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GCU53_RS05215	COG0438	transferase activity, transferring glycosyl groups
GCU53_RS05260	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GCU53_RS05275	COG2133	pyrroloquinoline quinone binding
GCU53_RS05295	COG1621	beta-fructofuranosidase activity
GCU53_RS05310	COG4221	oxidoreductase activity
GCU53_RS05340	COG0167	dihydroorotate dehydrogenase activity
GCU53_RS05345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCU53_RS05350	COG1129	ABC transporter
GCU53_RS05350	COG0842	Transport permease protein
GCU53_RS05355	COG0842	Transport permease protein
GCU53_RS05375	COG0583	DNA-binding transcription factor activity
GCU53_RS05380	COG0427	acetyl-CoA hydrolase
GCU53_RS05385	COG0427	acetyl-CoA hydrolase
GCU53_RS05405	COG1960	acyl-CoA dehydrogenase activity
GCU53_RS05410	COG1250	3-hydroxyacyl-CoA dehydrogenase
GCU53_RS05410	COG1024	Enoyl-CoA hydratase
GCU53_RS05415	COG0183	Belongs to the thiolase family
GCU53_RS05425	COG2814	Major facilitator Superfamily
GCU53_RS05460	COG3039	Transposase
GCU53_RS05475	COG1643	Atp-dependent helicase
GCU53_RS05480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GCU53_RS05485	COG0438	transferase activity, transferring glycosyl groups
GCU53_RS05510	COG1216	Glycosyl transferase, family 2
GCU53_RS05510	COG0438	transferase activity, transferring glycosyl groups
GCU53_RS05545	COG3039	Transposase
GCU53_RS05610	COG1091	dTDP-4-dehydrorhamnose reductase activity
GCU53_RS05640	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GCU53_RS05665	COG0463	Glycosyl transferase, family 2
GCU53_RS05670	COG0438	transferase activity, transferring glycosyl groups
GCU53_RS05710	COG0438	transferase activity, transferring glycosyl groups
GCU53_RS05725	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GCU53_RS05735	COG0776	regulation of translation
GCU53_RS05745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GCU53_RS05750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GCU53_RS05765	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GCU53_RS05775	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GCU53_RS05780	COG0402	S-adenosylhomocysteine deaminase activity
GCU53_RS05785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GCU53_RS05790	COG0546	phosphoglycolate phosphatase activity
GCU53_RS05795	COG1028	Short-chain dehydrogenase reductase Sdr
GCU53_RS05805	COG0800	Aldolase
GCU53_RS05830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GCU53_RS05835	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GCU53_RS05840	COG0009	L-threonylcarbamoyladenylate synthase
GCU53_RS05845	COG0613	PHP domain protein
GCU53_RS05850	COG2917	probably involved in intracellular septation
GCU53_RS05855	COG2350	Protein conserved in bacteria
GCU53_RS05860	COG0745	RESPONSE REGULATOR receiver
GCU53_RS05870	COG0642	Histidine kinase
GCU53_RS05875	COG0778	Nitroreductase
GCU53_RS05880	COG0727	PFAM Uncharacterised protein family (UPF0153)
GCU53_RS05885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GCU53_RS05890	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GCU53_RS05890	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GCU53_RS05905	COG0842	Transport permease protein
GCU53_RS05910	COG1131	(ABC) transporter
GCU53_RS05925	COG0582	viral genome integration into host DNA
GCU53_RS06020	COG4999	Histidine kinase
GCU53_RS06020	COG3850	Histidine kinase
GCU53_RS06020	COG3437	response regulator, receiver
GCU53_RS06020	COG2205	protein histidine kinase activity
GCU53_RS06025	COG0386	Belongs to the glutathione peroxidase family
GCU53_RS06030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GCU53_RS06035	COG0436	Aminotransferase
GCU53_RS06045	COG0501	Belongs to the peptidase M48B family
GCU53_RS06055	COG0500	methyltransferase
GCU53_RS06080	COG0625	glutathione transferase activity
GCU53_RS06110	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GCU53_RS06120	COG0730	response to heat
GCU53_RS06130	COG1846	Transcriptional regulator
GCU53_RS06135	COG1764	response to oxidative stress
GCU53_RS06160	COG3135	benzoate transporter
GCU53_RS06220	COG2814	Major facilitator Superfamily
GCU53_RS06225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GCU53_RS06230	COG4569	acetaldehyde dehydrogenase (acetylating) activity
GCU53_RS06235	COG3971	2-oxopent-4-enoate hydratase activity
GCU53_RS06240	COG1414	Transcriptional regulator
GCU53_RS06245	COG2267	carboxylic ester hydrolase activity
GCU53_RS06250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GCU53_RS06260	COG1355	regulation of microtubule-based process
GCU53_RS06275	COG0084	hydrolase, TatD family'
GCU53_RS06290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GCU53_RS06295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GCU53_RS06305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GCU53_RS06310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GCU53_RS06325	COG0416	fatty acid biosynthetic process
GCU53_RS06330	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GCU53_RS06340	COG0424	maF-like protein
GCU53_RS06345	COG0616	signal peptide processing
GCU53_RS06345	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GCU53_RS06350	COG0546	phosphoglycolate phosphatase activity
GCU53_RS06365	COG1530	ribonuclease E activity
GCU53_RS06370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GCU53_RS06375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GCU53_RS06380	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GCU53_RS06385	COG2835	tetraacyldisaccharide 4'-kinase activity
GCU53_RS06390	COG1663	tetraacyldisaccharide 4'-kinase activity
GCU53_RS06395	COG0848	biopolymer transport protein
GCU53_RS06400	COG0811	peptide transport
GCU53_RS06405	COG2333	competence protein COMEC
GCU53_RS06405	COG0658	competence protein
GCU53_RS06415	COG4591	ABC-type transport system involved in lipoprotein release permease component
GCU53_RS06420	COG1136	(ABC) transporter
GCU53_RS06425	COG4591	ABC-type transport system involved in lipoprotein release permease component
GCU53_RS06430	COG0584	glycerophosphoryl diester phosphodiesterase
GCU53_RS06435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GCU53_RS06445	COG1477	protein flavinylation
GCU53_RS06470	COG1805	sodium ion transport
GCU53_RS06485	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GCU53_RS06495	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GCU53_RS06515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GCU53_RS06545	COG0183	Belongs to the thiolase family
GCU53_RS06550	COG1024	Enoyl-CoA hydratase
GCU53_RS06550	COG1250	3-hydroxyacyl-CoA dehydrogenase
GCU53_RS06595	COG0281	malic enzyme
GCU53_RS06605	COG0589	response to stress
GCU53_RS06615	COG0488	(ABC) transporter
GCU53_RS06630	COG0303	'Molybdopterin
GCU53_RS06635	COG0521	Mo-molybdopterin cofactor biosynthetic process
GCU53_RS06665	COG3436	PFAM IS66 Orf2 family protein
GCU53_RS06670	COG2433	Pfam Transposase IS66
GCU53_RS06715	COG0137	argininosuccinate synthase activity
GCU53_RS06720	COG0418	dihydroorotase activity
GCU53_RS06725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GCU53_RS06740	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GCU53_RS06750	COG3842	ATPase activity
GCU53_RS06765	COG2267	carboxylic ester hydrolase activity
GCU53_RS06775	COG0583	DNA-binding transcription factor activity
GCU53_RS06795	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GCU53_RS06800	COG1454	alcohol dehydrogenase
GCU53_RS06805	COG1414	Transcriptional regulator
GCU53_RS06815	COG2226	methyltransferase
GCU53_RS06820	COG0500	methyltransferase
GCU53_RS06830	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GCU53_RS06835	COG1381	Involved in DNA repair and RecF pathway recombination
GCU53_RS06845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GCU53_RS06850	COG0571	ribonuclease III activity
GCU53_RS06865	COG0481	GTPase activity
GCU53_RS06870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GCU53_RS06895	COG3039	Transposase
GCU53_RS06920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GCU53_RS06930	COG1024	Enoyl-CoA hydratase
GCU53_RS06960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GCU53_RS06965	COG3030	protein affecting phage T7 exclusion by the F plasmid
GCU53_RS06975	COG1028	Short-chain dehydrogenase reductase Sdr
GCU53_RS06990	COG1666	GTP binding
GCU53_RS07005	COG2096	Adenosyltransferase
GCU53_RS07010	COG0494	nUDIX hydrolase
GCU53_RS07025	COG0653	protein targeting
GCU53_RS07040	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GCU53_RS07060	COG1181	Belongs to the D-alanine--D-alanine ligase family
GCU53_RS07065	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GCU53_RS07070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GCU53_RS07075	COG0772	Belongs to the SEDS family
GCU53_RS07080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GCU53_RS07085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GCU53_RS07090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GCU53_RS07095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GCU53_RS07110	COG0275	rRNA processing
GCU53_RS07115	COG2001	Belongs to the MraZ family
GCU53_RS07135	COG0792	nuclease activity
GCU53_RS07140	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GCU53_RS07145	COG2823	Periplasmic or secreted lipoprotein
GCU53_RS07150	COG2969	positive regulation of protein catabolic process
GCU53_RS07155	COG0625	glutathione transferase activity
GCU53_RS07160	COG2857	Cytochrome c1
GCU53_RS07165	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GCU53_RS07170	COG0723	plastoquinol--plastocyanin reductase activity
GCU53_RS07175	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GCU53_RS07180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GCU53_RS07185	COG1515	deoxyribonuclease V activity
GCU53_RS07190	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GCU53_RS07215	COG0175	sulfate reduction
GCU53_RS07225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GCU53_RS07230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GCU53_RS07240	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GCU53_RS07245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GCU53_RS07265	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GCU53_RS07270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GCU53_RS07275	COG1127	ABC transporter
GCU53_RS07285	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GCU53_RS07295	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GCU53_RS07300	COG1137	ATPase activity
GCU53_RS07320	COG1660	Displays ATPase and GTPase activities
GCU53_RS07330	COG0312	modulator of DNA gyrase
GCU53_RS07335	COG3028	Belongs to the UPF0307 family
GCU53_RS07340	COG0312	modulator of DNA gyrase
GCU53_RS07345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GCU53_RS07355	COG1530	ribonuclease E activity
GCU53_RS07360	COG0424	maF-like protein
GCU53_RS07365	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GCU53_RS07370	COG1792	Involved in formation and maintenance of cell shape
GCU53_RS07375	COG1077	Cell shape determining protein MreB Mrl
GCU53_RS07380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GCU53_RS07385	COG0154	amidase activity
GCU53_RS07390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GCU53_RS07410	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
GCU53_RS07430	COG0747	negative chemotaxis
GCU53_RS07435	COG0601	transmembrane transport
GCU53_RS07440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GCU53_RS07445	COG0444	Belongs to the ABC transporter superfamily
GCU53_RS07450	COG4608	Belongs to the ABC transporter superfamily
GCU53_RS07460	COG1984	allophanate hydrolase subunit 2
GCU53_RS07480	COG4774	siderophore transport
GCU53_RS07485	COG3128	pkhd-type hydroxylase
GCU53_RS07510	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GCU53_RS07520	COG0019	diaminopimelate decarboxylase activity
GCU53_RS07525	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GCU53_RS07540	COG1105	Belongs to the carbohydrate kinase PfkB family
GCU53_RS07565	COG0084	hydrolase, TatD family'
GCU53_RS07575	COG3023	N-Acetylmuramoyl-L-alanine amidase
GCU53_RS07590	COG4969	Belongs to the N-Me-Phe pilin family
GCU53_RS07605	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GCU53_RS07610	COG0237	dephospho-CoA kinase activity
GCU53_RS07640	COG1252	NADH dehydrogenase
GCU53_RS07705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GCU53_RS07735	COG4969	Belongs to the N-Me-Phe pilin family
GCU53_RS07745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GCU53_RS07750	COG1047	Peptidyl-prolyl cis-trans
GCU53_RS07755	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GCU53_RS07760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GCU53_RS07765	COG0196	riboflavin kinase activity
GCU53_RS07770	COG0728	peptidoglycan biosynthetic process
GCU53_RS07775	COG0268	Binds directly to 16S ribosomal RNA
GCU53_RS07780	COG3045	CreA protein
GCU53_RS07785	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GCU53_RS07790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GCU53_RS07795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GCU53_RS07800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GCU53_RS07805	COG0142	geranyltranstransferase activity
GCU53_RS07810	COG0545	Peptidyl-prolyl cis-trans isomerase
GCU53_RS07815	COG2862	Uncharacterized protein family, UPF0114
GCU53_RS07825	COG1067	ATP-dependent peptidase activity
GCU53_RS07865	COG0488	(ABC) transporter
GCU53_RS07870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GCU53_RS07880	COG0523	cobalamin synthesis protein
GCU53_RS07885	COG2879	small protein
GCU53_RS07890	COG1966	Carbon starvation protein
GCU53_RS07905	COG2020	methyltransferase activity
GCU53_RS07925	COG2203	Gaf domain
GCU53_RS07925	COG2199	diguanylate cyclase activity
GCU53_RS07925	COG2200	EAL domain
GCU53_RS07930	COG1970	mechanosensitive ion channel activity
GCU53_RS07935	COG0386	Belongs to the glutathione peroxidase family
GCU53_RS07950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GCU53_RS07965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GCU53_RS07975	COG2989	Protein conserved in bacteria
GCU53_RS07985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GCU53_RS07990	COG2813	Specifically methylates the guanine in position
GCU53_RS07995	COG2119	membrane
GCU53_RS08000	COG2119	membrane
GCU53_RS08005	COG0501	Belongs to the peptidase M48B family
GCU53_RS08010	COG2135	peptidase activity
GCU53_RS08045	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GCU53_RS08050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GCU53_RS08055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GCU53_RS08060	COG1090	epimerase
GCU53_RS08065	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
GCU53_RS08075	COG0789	Transcriptional regulator
GCU53_RS08080	COG0415	Belongs to the DNA photolyase family
GCU53_RS08085	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GCU53_RS08090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GCU53_RS08100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GCU53_RS08105	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GCU53_RS08120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GCU53_RS08135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GCU53_RS08140	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GCU53_RS08145	COG0193	aminoacyl-tRNA hydrolase activity
GCU53_RS08165	COG1025	Belongs to the peptidase M16 family
GCU53_RS08175	COG0535	radical SAM domain protein
GCU53_RS08185	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
GCU53_RS08190	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GCU53_RS08200	COG3284	Transcriptional regulator
GCU53_RS08205	COG1028	Short-chain dehydrogenase reductase Sdr
GCU53_RS08210	COG3199	ATP-NAD kinase
GCU53_RS08215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GCU53_RS08220	COG0022	dehydrogenase e1 component
GCU53_RS08230	COG1063	alcohol dehydrogenase
GCU53_RS08250	COG0659	secondary active sulfate transmembrane transporter activity
GCU53_RS08260	COG3093	addiction module antidote protein HigA
GCU53_RS08270	COG0583	DNA-binding transcription factor activity
GCU53_RS08275	COG3135	benzoate transporter
GCU53_RS08300	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GCU53_RS08315	COG0456	acetyltransferase
GCU53_RS08325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GCU53_RS08330	COG3008	intermembrane lipid transfer
GCU53_RS08335	COG2995	paraquat-inducible protein a
GCU53_RS08340	COG2995	paraquat-inducible protein a
GCU53_RS08370	COG1183	phosphatidylcholine synthase activity
GCU53_RS08375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GCU53_RS08385	COG0028	Belongs to the TPP enzyme family
GCU53_RS08395	COG3098	single-species biofilm formation
GCU53_RS08405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GCU53_RS08425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GCU53_RS08435	COG1489	DNA binding
GCU53_RS08440	COG0436	Aminotransferase
GCU53_RS08445	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GCU53_RS08450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GCU53_RS08460	COG3852	Histidine kinase
GCU53_RS08470	COG0617	tRNA 3'-terminal CCA addition
GCU53_RS08480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GCU53_RS08485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GCU53_RS08490	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GCU53_RS08495	COG0166	Belongs to the GPI family
GCU53_RS08515	COG1185	polyribonucleotide nucleotidyltransferase activity
GCU53_RS08520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GCU53_RS08530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GCU53_RS08535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GCU53_RS08540	COG0195	Participates in both transcription termination and antitermination
GCU53_RS08545	COG0779	Required for maturation of 30S ribosomal subunits
GCU53_RS08560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GCU53_RS08570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GCU53_RS08575	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GCU53_RS08580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GCU53_RS08585	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GCU53_RS08610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GCU53_RS08615	COG0484	heat shock protein binding
GCU53_RS08620	COG0443	Heat shock 70 kDa protein
GCU53_RS08625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GCU53_RS08630	COG0497	DNA recombination
GCU53_RS08640	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GCU53_RS08645	COG2914	Belongs to the UPF0125 (RnfH) family
GCU53_RS08655	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GCU53_RS08665	COG1620	l-lactate permease
GCU53_RS08670	COG0247	lactate metabolic process
GCU53_RS08675	COG1139	Iron-sulfur cluster binding protein
GCU53_RS08690	COG2205	protein histidine kinase activity
GCU53_RS08705	COG1741	Belongs to the pirin family
GCU53_RS08730	COG3150	esterase
GCU53_RS08735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GCU53_RS08745	COG0626	cystathionine gamma-synthase activity
GCU53_RS08755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GCU53_RS08765	COG3829	transcription factor binding
GCU53_RS08775	COG1309	transcriptional regulator
GCU53_RS08805	COG3436	PFAM IS66 Orf2 family protein
GCU53_RS08855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GCU53_RS08860	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GCU53_RS08880	COG2995	paraquat-inducible protein a
GCU53_RS08885	COG3008	intermembrane lipid transfer
GCU53_RS08885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GCU53_RS08895	COG0628	permease
GCU53_RS08915	COG1132	(ABC) transporter
GCU53_RS08920	COG0156	8-amino-7-oxononanoate synthase activity
GCU53_RS08925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GCU53_RS08935	COG0318	PFAM AMP-dependent synthetase and ligase
GCU53_RS08945	COG0456	acetyltransferase
GCU53_RS08960	COG0795	lipopolysaccharide-transporting ATPase activity
GCU53_RS08970	COG1183	phosphatidylcholine synthase activity
GCU53_RS08975	COG1597	lipid kinase activity
GCU53_RS09025	COG0463	Glycosyl transferase, family 2
GCU53_RS09050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GCU53_RS09070	COG0494	nUDIX hydrolase
GCU53_RS09080	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GCU53_RS09085	COG1519	Transferase
GCU53_RS09095	COG0667	Aldo Keto reductase
GCU53_RS09105	COG2755	lipolytic protein G-D-S-L family
GCU53_RS09105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GCU53_RS09110	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GCU53_RS09110	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GCU53_RS09130	COG1132	(ABC) transporter
GCU53_RS09145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GCU53_RS09150	COG1442	glycosyl transferase family 8
GCU53_RS09155	COG3562	capsule polysaccharide
GCU53_RS09170	COG0438	transferase activity, transferring glycosyl groups
GCU53_RS09175	COG2192	nodulation
GCU53_RS09195	COG0438	transferase activity, transferring glycosyl groups
GCU53_RS09200	COG0859	PFAM glycosyl transferase family 9
GCU53_RS09205	COG0859	PFAM glycosyl transferase family 9
GCU53_RS09230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GCU53_RS09235	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GCU53_RS09240	COG0583	DNA-binding transcription factor activity
GCU53_RS09250	COG1942	4-Oxalocrotonate Tautomerase
GCU53_RS09255	COG3263	regulation of cellular component size
GCU53_RS09260	COG1196	nuclear chromosome segregation
GCU53_RS09260	COG3264	Mechanosensitive ion channel
GCU53_RS09265	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GCU53_RS09275	COG0730	response to heat
GCU53_RS09280	COG3118	belongs to the thioredoxin family
GCU53_RS09290	COG1192	Involved in chromosome partitioning
GCU53_RS09295	COG0583	DNA-binding transcription factor activity
GCU53_RS09300	COG2814	Major facilitator Superfamily
GCU53_RS09310	COG0493	'glutamate synthase
GCU53_RS09315	COG0067	glutamate synthase
GCU53_RS09315	COG0070	glutamate synthase
GCU53_RS09315	COG0069	glutamate synthase activity
GCU53_RS09325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GCU53_RS09330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GCU53_RS09370	COG0281	malic enzyme
GCU53_RS09375	COG1525	nuclease
GCU53_RS09375	COG0737	Belongs to the 5'-nucleotidase family
GCU53_RS09375	COG4085	toxin activity
GCU53_RS09380	COG0254	rRNA binding
GCU53_RS09385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GCU53_RS09390	COG0018	arginyl-trna synthetase
GCU53_RS09400	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GCU53_RS09405	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GCU53_RS09415	COG2226	methyltransferase
GCU53_RS09425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GCU53_RS09440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GCU53_RS09445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GCU53_RS09490	COG1490	D-aminoacyl-tRNA deacylase activity
GCU53_RS09505	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GCU53_RS09530	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GCU53_RS09535	COG0058	SHG alpha-glucan phosphorylase activity
GCU53_RS09545	COG1007	ATP synthesis coupled electron transport
GCU53_RS09550	COG0651	ATP synthesis coupled electron transport
GCU53_RS09630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GCU53_RS09650	COG1217	gtp-binding protein TYPA
GCU53_RS09655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCU53_RS09655	COG0301	tRNA thio-modification
GCU53_RS09675	COG3852	Histidine kinase
GCU53_RS09690	COG1960	acyl-CoA dehydrogenase activity
GCU53_RS09715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GCU53_RS09720	COG0716	FMN binding
GCU53_RS09770	COG0537	adenosine 5'-monophosphoramidase activity
GCU53_RS09775	COG4589	Belongs to the CDS family
GCU53_RS09780	COG0204	Acyl-transferase
GCU53_RS09785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GCU53_RS09795	COG0596	Alpha beta hydrolase
GCU53_RS09800	COG0156	8-amino-7-oxononanoate synthase activity
GCU53_RS09810	COG1040	competence protein
GCU53_RS09815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GCU53_RS09825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GCU53_RS09845	COG1125	glycine betaine transport
GCU53_RS09845	COG0517	IMP dehydrogenase activity
GCU53_RS09850	COG2176	DNA-directed DNA polymerase activity
GCU53_RS09855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GCU53_RS09865	COG0204	Acyl-transferase
GCU53_RS09885	COG2814	Major facilitator Superfamily
GCU53_RS09895	COG0625	glutathione transferase activity
GCU53_RS09905	COG1309	transcriptional regulator
GCU53_RS09915	COG2610	gluconate transmembrane transporter activity
GCU53_RS09935	COG0686	Belongs to the AlaDH PNT family
GCU53_RS09940	COG0330	HflC and HflK could
GCU53_RS09950	COG1289	transmembrane transporter activity
GCU53_RS09960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GCU53_RS09965	COG2354	Protein conserved in bacteria
GCU53_RS09975	COG1451	nucleotide metabolic process
GCU53_RS09980	COG1349	DNA-binding transcription factor activity
GCU53_RS09985	COG0673	inositol 2-dehydrogenase activity
GCU53_RS09990	COG4702	Belongs to the UPF0303 family
GCU53_RS10000	COG0126	phosphoglycerate kinase activity
GCU53_RS10010	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GCU53_RS10015	COG2226	methyltransferase
GCU53_RS10020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GCU53_RS10030	COG1218	3'(2'),5'-bisphosphate nucleotidase
GCU53_RS10035	COG0494	nUDIX hydrolase
GCU53_RS10040	COG1011	Hydrolase
GCU53_RS10055	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GCU53_RS10060	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GCU53_RS10080	COG0489	protein tyrosine kinase activity
GCU53_RS10110	COG1215	transferase activity, transferring glycosyl groups
GCU53_RS10155	COG2271	Major facilitator Superfamily
GCU53_RS10165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCU53_RS10175	COG2721	sulfolactate sulfo-lyase activity
GCU53_RS10180	COG2271	Major facilitator Superfamily
GCU53_RS10185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GCU53_RS10190	COG2186	Transcriptional regulator
GCU53_RS10195	COG1012	belongs to the aldehyde dehydrogenase family
GCU53_RS10205	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GCU53_RS10210	COG4067	protein conserved in archaea
GCU53_RS10210	COG0189	ligase activity
GCU53_RS10215	COG0189	ligase activity
GCU53_RS10245	COG0457	Tetratricopeptide repeat
GCU53_RS10255	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GCU53_RS10260	COG2183	response to ionizing radiation
GCU53_RS10270	COG2918	glutathione biosynthetic process
GCU53_RS10275	COG5263	repeat protein
GCU53_RS10275	COG0366	Alpha amylase catalytic
GCU53_RS10325	COG1450	Type ii and iii secretion system protein
GCU53_RS10330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GCU53_RS10335	COG1459	type II secretion system
GCU53_RS10340	COG2165	general secretion pathway protein
GCU53_RS10355	COG4795	General secretion pathway protein
GCU53_RS10375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GCU53_RS10375	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GCU53_RS10385	COG0306	phosphate transporter
GCU53_RS10390	COG1392	Phosphate transport regulator
GCU53_RS10395	COG3025	triphosphatase activity
GCU53_RS10405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GCU53_RS10420	COG3132	Protein of unknown function, DUF480
GCU53_RS10425	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GCU53_RS10430	COG1127	ABC transporter
GCU53_RS10435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GCU53_RS10435	COG3218	ABC-type transport auxiliary lipoprotein component
GCU53_RS10450	COG2204	response regulator
GCU53_RS10455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GCU53_RS10460	COG0583	DNA-binding transcription factor activity
GCU53_RS10465	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GCU53_RS10470	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GCU53_RS10485	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GCU53_RS10490	COG4942	peptidase
GCU53_RS10495	COG0793	Belongs to the peptidase S41A family
GCU53_RS10500	COG0107	imidazoleglycerol-phosphate synthase activity
GCU53_RS10510	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GCU53_RS10515	COG0131	Imidazoleglycerol-phosphate dehydratase
GCU53_RS10530	COG1194	a g-specific adenine glycosylase
GCU53_RS10535	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GCU53_RS10555	COG1151	hydroxylamine reductase activity
GCU53_RS10585	COG2194	sulfuric ester hydrolase activity
GCU53_RS10600	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCU53_RS10610	COG0543	2 iron, 2 sulfur cluster binding
GCU53_RS10660	COG0366	Alpha amylase catalytic
GCU53_RS10670	COG3039	Transposase
GCU53_RS10755	COG0346	lactoylglutathione lyase activity
GCU53_RS10795	COG1396	sequence-specific DNA binding
GCU53_RS10840	COG0583	DNA-binding transcription factor activity
GCU53_RS10905	COG2864	formate dehydrogenase
GCU53_RS10910	COG0437	4 iron, 4 sulfur cluster binding
GCU53_RS10915	COG3383	formate dehydrogenase (NAD+) activity
GCU53_RS10915	COG0243	molybdopterin cofactor binding
GCU53_RS10920	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GCU53_RS10925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GCU53_RS10955	COG0583	DNA-binding transcription factor activity
GCU53_RS10990	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GCU53_RS11000	COG0738	Major facilitator superfamily
GCU53_RS11005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GCU53_RS11025	COG0513	Belongs to the DEAD box helicase family
GCU53_RS11055	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GCU53_RS11135	COG2353	YceI-like domain
GCU53_RS11140	COG3038	cytochrome b561
GCU53_RS11160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GCU53_RS11175	COG2198	Histidine kinase
GCU53_RS11175	COG0784	Response regulator, receiver
GCU53_RS11175	COG0643	Histidine kinase
GCU53_RS11175	COG0643	Histidine kinase
GCU53_RS11175	COG0784	Response regulator, receiver
GCU53_RS11175	COG2198	Histidine kinase
GCU53_RS11180	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GCU53_RS11220	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GCU53_RS11230	COG0540	Belongs to the ATCase OTCase family
GCU53_RS11270	COG1872	DUF167
GCU53_RS11275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GCU53_RS11280	COG2813	Specifically methylates the guanine in position
GCU53_RS11280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GCU53_RS11295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GCU53_RS11305	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GCU53_RS11310	COG2022	thiamine diphosphate biosynthetic process
GCU53_RS11320	COG2363	Small membrane protein
GCU53_RS11325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GCU53_RS11330	COG2003	Belongs to the UPF0758 family
GCU53_RS11335	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GCU53_RS11340	COG0756	dUTP diphosphatase activity
GCU53_RS11350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GCU53_RS11360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GCU53_RS11365	COG0708	Exodeoxyribonuclease III
GCU53_RS11375	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GCU53_RS11380	COG1561	YicC-like family, N-terminal region
GCU53_RS11395	COG1758	RNA polymerase activity
GCU53_RS11400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GCU53_RS11420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GCU53_RS11435	COG2841	Protein conserved in bacteria
GCU53_RS11440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GCU53_RS11445	COG3039	Transposase
GCU53_RS11460	COG3039	Transposase
GCU53_RS11465	COG3039	Transposase
GCU53_RS11485	COG0366	Alpha amylase catalytic
GCU53_RS11495	COG2982	Protein involved in outer membrane biogenesis
GCU53_RS11505	COG3237	CsbD-like
GCU53_RS11520	COG2356	endonuclease I
GCU53_RS11570	COG0789	Transcriptional regulator
GCU53_RS11575	COG0484	heat shock protein binding
GCU53_RS11620	COG0159	tryptophan synthase activity
GCU53_RS11625	COG0133	tryptophan synthase activity
GCU53_RS11635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GCU53_RS11655	COG1132	(ABC) transporter
GCU53_RS11665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GCU53_RS11670	COG5016	pyruvate
GCU53_RS11670	COG0511	ligase activity, forming carbon-carbon bonds
GCU53_RS11675	COG0439	Biotin carboxylase
GCU53_RS11680	COG0583	DNA-binding transcription factor activity
GCU53_RS11690	COG1737	Transcriptional regulator
GCU53_RS11695	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GCU53_RS11700	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GCU53_RS11720	COG3023	N-Acetylmuramoyl-L-alanine amidase
GCU53_RS11725	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GCU53_RS11750	COG1858	cytochrome C peroxidase
GCU53_RS11775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCU53_RS11780	COG3293	Transposase
GCU53_RS11810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GCU53_RS11845	COG1764	response to oxidative stress
GCU53_RS11855	COG1283	sodium-dependent phosphate transmembrane transporter activity
GCU53_RS11865	COG1607	acyl-coa hydrolase
GCU53_RS11880	COG0523	cobalamin synthesis protein
GCU53_RS11995	COG3411	Ferredoxin
GCU53_RS12080	COG0318	PFAM AMP-dependent synthetase and ligase
GCU53_RS12080	COG0204	Acyl-transferase
GCU53_RS12110	COG1686	Belongs to the peptidase S11 family
GCU53_RS12115	COG2261	transglycosylase associated protein
GCU53_RS12130	COG0252	asparaginase activity
GCU53_RS12155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GCU53_RS12165	COG3712	iron ion homeostasis
GCU53_RS12200	COG0659	secondary active sulfate transmembrane transporter activity
GCU53_RS12220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GCU53_RS12250	COG1612	heme a metabolic process
GCU53_RS12255	COG0109	protoheme IX farnesyltransferase activity
GCU53_RS12270	COG0737	Belongs to the 5'-nucleotidase family
GCU53_RS12270	COG1525	nuclease
GCU53_RS12270	COG4085	toxin activity
GCU53_RS12280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GCU53_RS12285	COG1121	(ABC) transporter
GCU53_RS12290	COG0735	belongs to the Fur family
GCU53_RS12295	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GCU53_RS12300	COG1305	Transglutaminase-like
GCU53_RS12355	COG3039	Transposase
GCU53_RS12380	COG0596	Alpha beta hydrolase
GCU53_RS12415	COG0826	peptidase U32
GCU53_RS12440	COG3706	GGDEF domain
GCU53_RS12455	COG0700	Nucleoside recognition
GCU53_RS12460	COG0655	NAD(P)H dehydrogenase (quinone) activity
GCU53_RS12465	COG3706	GGDEF domain
GCU53_RS12515	COG1285	pathogenesis
GCU53_RS12535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GCU53_RS12540	COG0408	coproporphyrinogen oxidase activity
GCU53_RS12550	COG0009	L-threonylcarbamoyladenylate synthase
GCU53_RS12555	COG0758	DNA mediated transformation
GCU53_RS12565	COG0242	peptide deformylase activity
GCU53_RS12575	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GCU53_RS12580	COG0569	domain protein
GCU53_RS12590	COG2818	Glycosylase
GCU53_RS12600	COG0751	glycine-tRNA ligase activity
GCU53_RS12605	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GCU53_RS12625	COG3436	PFAM IS66 Orf2 family protein
GCU53_RS12635	COG2837	iron assimilation
GCU53_RS12650	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GCU53_RS12660	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GCU53_RS12670	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GCU53_RS12675	COG0594	ribonuclease P activity
GCU53_RS12680	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GCU53_RS12685	COG0706	membrane insertase activity
GCU53_RS12700	COG0357	Ribosomal RNA small subunit methyltransferase G
GCU53_RS12705	COG1192	Involved in chromosome partitioning
GCU53_RS12710	COG1475	DNA binding
GCU53_RS12715	COG3312	ion transport
GCU53_RS12720	COG0356	it plays a direct role in the translocation of protons across the membrane
GCU53_RS12730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GCU53_RS12735	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GCU53_RS12740	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GCU53_RS12745	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GCU53_RS12750	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GCU53_RS12755	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GCU53_RS12800	COG1136	(ABC) transporter
GCU53_RS12800	COG0577	efflux transmembrane transporter activity
GCU53_RS12810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GCU53_RS12830	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GCU53_RS12835	COG1349	DNA-binding transcription factor activity
GCU53_RS12840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GCU53_RS12855	COG1621	beta-fructofuranosidase activity
GCU53_RS12885	COG0366	Alpha amylase catalytic
GCU53_RS12915	COG1082	Xylose isomerase domain protein TIM barrel
GCU53_RS12920	COG1272	protein, Hemolysin III
GCU53_RS12935	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GCU53_RS12940	COG1074	ATP-dependent DNA helicase activity
GCU53_RS12945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GCU53_RS12970	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GCU53_RS13010	COG3766	membrane
GCU53_RS13020	COG0754	glutathionylspermidine amidase activity
GCU53_RS13030	COG3039	Transposase
GCU53_RS13040	COG0840	transmembrane signaling receptor activity
GCU53_RS13065	COG0583	DNA-binding transcription factor activity
GCU53_RS13070	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GCU53_RS13085	COG1250	3-hydroxyacyl-CoA dehydrogenase
GCU53_RS13090	COG1538	Outer membrane efflux protein
GCU53_RS13110	COG0667	Aldo Keto reductase
GCU53_RS13125	COG0366	Alpha amylase catalytic
GCU53_RS13130	COG3039	Transposase
GCU53_RS13140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GCU53_RS13145	COG0366	Alpha amylase catalytic
GCU53_RS13165	COG2211	Major facilitator Superfamily
GCU53_RS13170	COG1486	melibiose metabolic process
GCU53_RS13180	COG2207	Transcriptional regulator
GCU53_RS13190	COG4580	involved in the transport of maltose and maltodextrins
GCU53_RS13200	COG1414	Transcriptional regulator
GCU53_RS13210	COG0800	Aldolase
GCU53_RS13215	COG4948	Mandelate Racemase Muconate Lactonizing
GCU53_RS13220	COG2271	Major facilitator Superfamily
GCU53_RS13275	COG2271	Major facilitator Superfamily
GCU53_RS13280	COG2116	formate transmembrane transporter activity
GCU53_RS13285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GCU53_RS13285	COG1017	nitric oxide dioxygenase activity
GCU53_RS13290	COG0517	IMP dehydrogenase activity
GCU53_RS13290	COG0516	GMP reductase activity
GCU53_RS13300	COG3604	Transcriptional regulator
GCU53_RS13305	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GCU53_RS13345	COG4657	Part of a membrane complex involved in electron transport
GCU53_RS13350	COG2878	Part of a membrane complex involved in electron transport
GCU53_RS13355	COG4656	Part of a membrane complex involved in electron transport
GCU53_RS13370	COG4660	Part of a membrane complex involved in electron transport
GCU53_RS13375	COG2914	Belongs to the UPF0125 (RnfH) family
GCU53_RS13390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GCU53_RS13395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GCU53_RS13405	COG4149	molybdate abc transporter
GCU53_RS13430	COG3842	ATPase activity
GCU53_RS13470	COG5002	protein histidine kinase activity
GCU53_RS13470	COG0784	Response regulator, receiver
GCU53_RS13470	COG2205	protein histidine kinase activity
GCU53_RS13600	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GCU53_RS13630	COG3251	PFAM MbtH domain protein
GCU53_RS13660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GCU53_RS13690	COG2366	antibiotic biosynthetic process
GCU53_RS13705	COG1120	ATPase activity
GCU53_RS13815	COG3039	Transposase
GCU53_RS13835	COG0149	triose-phosphate isomerase activity
GCU53_RS13855	COG2132	Multicopper oxidase
GCU53_RS13865	COG0861	Integral membrane protein TerC family
GCU53_RS13870	COG2851	Citrate transporter
GCU53_RS13895	COG0673	inositol 2-dehydrogenase activity
GCU53_RS13920	COG1960	acyl-CoA dehydrogenase activity
GCU53_RS13925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GCU53_RS13945	COG3180	Ammonia monooxygenase
GCU53_RS14010	COG1136	(ABC) transporter
GCU53_RS14035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GCU53_RS14040	COG0596	Alpha beta hydrolase
GCU53_RS14120	COG0667	Aldo Keto reductase
GCU53_RS14140	COG3909	cytochrome
GCU53_RS14165	COG3706	GGDEF domain
GCU53_RS14175	COG0640	Transcriptional regulator
GCU53_RS14180	COG2957	Belongs to the agmatine deiminase family
GCU53_RS14190	COG0174	glutamine synthetase
GCU53_RS14195	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GCU53_RS14200	COG0174	glutamine synthetase
GCU53_RS14230	COG3039	Transposase
GCU53_RS14240	COG3842	ATPase activity
GCU53_RS14245	COG1176	ABC-type spermidine putrescine transport system, permease component I
GCU53_RS14250	COG1177	transmembrane transport
GCU53_RS14255	COG0625	glutathione transferase activity
GCU53_RS14270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCU53_RS14305	COG0676	glucose-6-phosphate 1-epimerase activity
GCU53_RS14310	COG1607	acyl-coa hydrolase
GCU53_RS14325	COG0573	inorganic phosphate transmembrane transporter activity
GCU53_RS14330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GCU53_RS14340	COG0739	heme binding
GCU53_RS14345	COG1253	flavin adenine dinucleotide binding
GCU53_RS14360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GCU53_RS14385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GCU53_RS14390	COG0583	DNA-binding transcription factor activity
GCU53_RS14435	COG3180	Ammonia monooxygenase
GCU53_RS14440	COG0679	Auxin Efflux Carrier
GCU53_RS14445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GCU53_RS14450	COG0277	FAD linked oxidase domain protein
GCU53_RS14455	COG0179	Fumarylacetoacetate (FAA) hydrolase
GCU53_RS14460	COG3204	pilus organization
GCU53_RS14470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GCU53_RS14495	COG0494	nUDIX hydrolase
GCU53_RS14500	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GCU53_RS14515	COG0730	response to heat
GCU53_RS14520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GCU53_RS14525	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GCU53_RS14535	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GCU53_RS14545	COG0584	glycerophosphoryl diester phosphodiesterase
GCU53_RS14570	COG2205	protein histidine kinase activity
GCU53_RS14610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GCU53_RS14615	COG0842	Transport permease protein
GCU53_RS14620	COG1131	(ABC) transporter
GCU53_RS14625	COG0840	transmembrane signaling receptor activity
GCU53_RS14630	COG0693	protein deglycase activity
GCU53_RS14635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GCU53_RS14655	COG0210	DNA helicase
GCU53_RS14665	COG0247	lactate metabolic process
GCU53_RS14675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GCU53_RS14680	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GCU53_RS14685	COG0429	hydrolase of the alpha beta-hydrolase fold
GCU53_RS14690	COG0742	ribosomal rna small subunit methyltransferase
GCU53_RS14695	COG0612	Peptidase, M16
GCU53_RS14700	COG0612	Peptidase, M16
GCU53_RS14705	COG0552	protein localization to endoplasmic reticulum
GCU53_RS14710	COG2884	Cell division ATP-binding protein ftsE
GCU53_RS14715	COG2177	Part of the ABC transporter FtsEX involved in
GCU53_RS14725	COG0747	negative chemotaxis
GCU53_RS14730	COG0235	Class ii aldolase
GCU53_RS14735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GCU53_RS14740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GCU53_RS14745	COG1012	belongs to the aldehyde dehydrogenase family
GCU53_RS14755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GCU53_RS14760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GCU53_RS14770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GCU53_RS14775	COG0251	oxidation-reduction process
GCU53_RS14795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GCU53_RS14810	COG0753	catalase activity
GCU53_RS14825	COG0437	4 iron, 4 sulfur cluster binding
GCU53_RS14870	COG1741	Belongs to the pirin family
GCU53_RS14880	COG0583	DNA-binding transcription factor activity
GCU53_RS14895	COG0606	chelatase, subunit chli
GCU53_RS14905	COG0347	Belongs to the P(II) protein family
GCU53_RS14910	COG0004	ammonium transporteR
GCU53_RS14915	COG0432	Pfam Uncharacterised protein family UPF0047
GCU53_RS14935	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GCU53_RS14945	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GCU53_RS14960	COG1965	Belongs to the frataxin family
GCU53_RS14975	COG0598	Magnesium transport protein CorA
GCU53_RS14980	COG0165	Argininosuccinate lyase
GCU53_RS15030	COG0488	(ABC) transporter
GCU53_RS15050	COG1671	Belongs to the UPF0178 family
GCU53_RS15055	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GCU53_RS15065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GCU53_RS15070	COG0248	Ppx GppA phosphatase
GCU53_RS15085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GCU53_RS15100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GCU53_RS15120	COG3079	Belongs to the UPF0149 family
GCU53_RS15125	COG0006	proline dipeptidase activity
GCU53_RS15130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GCU53_RS15135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GCU53_RS15145	COG1178	ABC-type Fe3 transport system permease component
GCU53_RS15160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GCU53_RS15160	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GCU53_RS15185	COG4772	TonB-dependent receptor
GCU53_RS15190	COG3712	iron ion homeostasis
GCU53_RS15195	COG1595	DNA-templated transcription, initiation
GCU53_RS15210	COG3387	PFAM Glycoside hydrolase 15-related
GCU53_RS15215	COG2323	membrane
GCU53_RS15225	COG0300	oxidoreductase activity
GCU53_RS15230	COG3546	catalase activity
GCU53_RS15235	COG1546	Belongs to the CinA family
GCU53_RS15250	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GCU53_RS15270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GCU53_RS15275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GCU53_RS15280	COG0358	DNA primase activity
GCU53_RS15290	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GCU53_RS15295	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GCU53_RS15300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GCU53_RS15330	COG0617	tRNA 3'-terminal CCA addition
GCU53_RS15335	COG2719	SpoVR family
GCU53_RS15340	COG2718	Belongs to the UPF0229 family
GCU53_RS15345	COG2766	serine protein kinase
GCU53_RS15350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCU53_RS15355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GCU53_RS15360	COG2967	ApaG domain
GCU53_RS15380	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GCU53_RS15390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GCU53_RS15395	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GCU53_RS15400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GCU53_RS15405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GCU53_RS15420	COG2249	NAD(P)H dehydrogenase (quinone) activity
GCU53_RS15445	COG0366	Alpha amylase catalytic
GCU53_RS15460	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
GCU53_RS15470	COG0583	DNA-binding transcription factor activity
GCU53_RS15475	COG4319	ketosteroid isomerase
GCU53_RS15480	COG3039	Transposase
GCU53_RS15495	COG2433	Pfam Transposase IS66
GCU53_RS15500	COG3436	PFAM IS66 Orf2 family protein
GCU53_RS15530	COG1404	Belongs to the peptidase S8 family
GCU53_RS15530	COG4935	Belongs to the peptidase S8 family
GCU53_RS15540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GCU53_RS15545	COG2267	carboxylic ester hydrolase activity
GCU53_RS15570	COG2169	Transcriptional regulator
GCU53_RS15570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GCU53_RS15590	COG2249	NAD(P)H dehydrogenase (quinone) activity
GCU53_RS15605	COG1335	isochorismatase
GCU53_RS15620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GCU53_RS15625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GCU53_RS15630	COG0022	dehydrogenase e1 component
GCU53_RS15630	COG0508	dehydrogenase complex catalyzes the overall conversion of
GCU53_RS15660	COG0512	Glutamine amidotransferase of anthranilate synthase
GCU53_RS15665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GCU53_RS15670	COG0134	indole-3-glycerol-phosphate synthase activity
GCU53_RS15680	COG1765	OsmC-like protein
GCU53_RS15685	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GCU53_RS15690	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GCU53_RS15695	COG0537	adenosine 5'-monophosphoramidase activity
GCU53_RS15700	COG1981	membrane
GCU53_RS15705	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GCU53_RS15710	COG0316	Belongs to the HesB IscA family
GCU53_RS15715	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GCU53_RS15720	COG0739	heme binding
GCU53_RS15725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GCU53_RS15740	COG2433	Pfam Transposase IS66
GCU53_RS15745	COG3436	PFAM IS66 Orf2 family protein
GCU53_RS15760	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GCU53_RS15760	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GCU53_RS15765	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GCU53_RS15810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GCU53_RS15815	COG0081	regulation of translation
GCU53_RS15820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GCU53_RS15825	COG0222	ribosome binding
GCU53_RS15830	COG0085	RNA polymerase activity
GCU53_RS15835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GCU53_RS15840	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GCU53_RS15845	COG0049	tRNA binding
GCU53_RS15860	COG0051	transcription antitermination factor activity, RNA binding
GCU53_RS15865	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GCU53_RS15870	COG0088	Forms part of the polypeptide exit tunnel
GCU53_RS15875	COG0089	rRNA binding
GCU53_RS15880	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GCU53_RS15885	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GCU53_RS15890	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GCU53_RS15895	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GCU53_RS15900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GCU53_RS15905	COG0255	Belongs to the universal ribosomal protein uL29 family
GCU53_RS15910	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GCU53_RS15915	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GCU53_RS15920	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GCU53_RS15930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GCU53_RS15935	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GCU53_RS15940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GCU53_RS15950	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GCU53_RS15960	COG0200	Binds to the 23S rRNA
GCU53_RS15970	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GCU53_RS15975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GCU53_RS15985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GCU53_RS15990	COG0202	RNA polymerase activity
GCU53_RS15995	COG0203	ribosomal protein L17
GCU53_RS16005	COG2814	Major facilitator Superfamily
GCU53_RS16020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCU53_RS16035	COG3047	cAMP biosynthetic process
GCU53_RS16040	COG3047	cAMP biosynthetic process
GCU53_RS16050	COG0811	peptide transport
GCU53_RS16055	COG0811	peptide transport
GCU53_RS16060	COG0848	biopolymer transport protein
GCU53_RS16090	COG4181	ATPase activity
GCU53_RS16105	COG3118	belongs to the thioredoxin family
GCU53_RS16110	COG2264	protein methyltransferase activity
GCU53_RS16120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GCU53_RS16125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GCU53_RS16125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GCU53_RS16140	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GCU53_RS16155	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GCU53_RS16165	COG3577	Aspartyl protease
GCU53_RS16170	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GCU53_RS16180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GCU53_RS16200	COG0443	Heat shock 70 kDa protein
GCU53_RS16215	COG0138	bifunctional purine biosynthesis protein purh
GCU53_RS16240	COG2264	protein methyltransferase activity
GCU53_RS16275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GCU53_RS16275	COG0546	phosphoglycolate phosphatase activity
GCU53_RS16300	COG3039	Transposase
GCU53_RS16305	COG4372	Transposase
GCU53_RS16310	COG3436	PFAM IS66 Orf2 family protein
GCU53_RS16320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GCU53_RS16325	COG0023	Translation Initiation Factor
GCU53_RS16330	COG1166	arginine decarboxylase activity
GCU53_RS16335	COG0534	Mate efflux family protein
GCU53_RS16345	COG0589	response to stress
GCU53_RS16350	COG0659	secondary active sulfate transmembrane transporter activity
GCU53_RS16385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GCU53_RS16415	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GCU53_RS16450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GCU53_RS16470	COG1126	abc transporter atp-binding protein
GCU53_RS16475	COG0765	amino acid transport
GCU53_RS16480	COG0765	amino acid transport
GCU53_RS16495	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GCU53_RS16505	COG1595	DNA-templated transcription, initiation
GCU53_RS16520	COG3220	belongs to the UPF0276 family
GCU53_RS16535	COG0183	Belongs to the thiolase family
GCU53_RS16555	COG3766	membrane
GCU53_RS16565	COG0560	Phosphoserine phosphatase
GCU53_RS16565	COG3830	Belongs to the UPF0237 family
GCU53_RS16570	COG1063	alcohol dehydrogenase
GCU53_RS16575	COG5001	Diguanylate cyclase
GCU53_RS16575	COG5002	protein histidine kinase activity
GCU53_RS16580	COG0688	phosphatidylethanolamine metabolic process
GCU53_RS16590	COG1162	GTPase activity
GCU53_RS16595	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GCU53_RS16605	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GCU53_RS16605	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GCU53_RS16610	COG0802	atpase or kinase
GCU53_RS16615	COG0860	N-Acetylmuramoyl-L-alanine amidase
GCU53_RS16620	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GCU53_RS16625	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GCU53_RS16630	COG1923	regulation of RNA biosynthetic process
GCU53_RS16635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GCU53_RS16640	COG0330	HflC and HflK could
GCU53_RS16645	COG0330	HflC and HflK could
GCU53_RS16655	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GCU53_RS16660	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GCU53_RS16675	COG0557	exoribonuclease II activity
GCU53_RS16685	COG0360	Binds together with S18 to 16S ribosomal RNA
GCU53_RS16690	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GCU53_RS16700	COG0359	binds to the 23S rRNA
GCU53_RS16705	COG0305	Participates in initiation and elongation during chromosome replication
GCU53_RS16735	COG2813	Specifically methylates the guanine in position
GCU53_RS16745	COG1946	Acyl-CoA thioesterase
GCU53_RS16750	COG0546	phosphoglycolate phosphatase activity
GCU53_RS16755	COG2321	neutral zinc metallopeptidase
GCU53_RS16770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GCU53_RS16775	COG2252	PERMEase
GCU53_RS16780	COG4771	TonB-dependent receptor
GCU53_RS16785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GCU53_RS16790	COG0142	geranyltranstransferase activity
GCU53_RS16795	COG1722	exodeoxyribonuclease VII activity
GCU53_RS16800	COG5001	Diguanylate cyclase
GCU53_RS16815	COG3228	Belongs to the MtfA family
GCU53_RS16825	COG1454	alcohol dehydrogenase
GCU53_RS16850	COG3284	Transcriptional regulator
GCU53_RS16855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GCU53_RS16890	COG0702	epimerase
GCU53_RS16900	COG1346	cytolysis
GCU53_RS16910	COG0366	Alpha amylase catalytic
GCU53_RS16915	COG0586	Pfam SNARE associated Golgi protein
GCU53_RS16920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GCU53_RS16925	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GCU53_RS16935	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GCU53_RS16940	COG0768	penicillin binding
GCU53_RS16945	COG0772	Belongs to the SEDS family
GCU53_RS16950	COG2951	lytic endotransglycosylase activity
GCU53_RS16960	COG1686	Belongs to the peptidase S11 family
GCU53_RS16965	COG2921	Belongs to the UPF0250 family
GCU53_RS16970	COG0321	lipoyl(octanoyl) transferase activity
GCU53_RS16975	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GCU53_RS16980	COG0028	Belongs to the TPP enzyme family
GCU53_RS17010	COG2951	lytic endotransglycosylase activity
GCU53_RS17085	COG2814	Major facilitator Superfamily
GCU53_RS17115	COG4569	acetaldehyde dehydrogenase (acetylating) activity
GCU53_RS17135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GCU53_RS17175	COG0495	leucyl-tRNA aminoacylation
GCU53_RS17185	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GCU53_RS17190	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GCU53_RS17200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GCU53_RS17205	COG1702	phosphate starvation-inducible protein PhoH
GCU53_RS17225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GCU53_RS17230	COG0352	thiamine-phosphate diphosphorylase activity
GCU53_RS17235	COG0351	phosphomethylpyrimidine kinase
GCU53_RS17240	COG1960	acyl-CoA dehydrogenase activity
GCU53_RS17245	COG0019	diaminopimelate decarboxylase activity
GCU53_RS17255	COG2814	Major facilitator Superfamily
GCU53_RS17260	COG4264	IucA IucC family
GCU53_RS17270	COG4772	TonB-dependent receptor
GCU53_RS17280	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GCU53_RS17285	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GCU53_RS17290	COG0830	nickel cation binding
GCU53_RS17295	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GCU53_RS17315	COG0804	urea catabolic process
GCU53_RS17320	COG0832	Belongs to the urease beta subunit family
GCU53_RS17325	COG0831	urea catabolic process
GCU53_RS17330	COG0829	nickel cation binding
GCU53_RS17340	COG4303	Ethanolamine ammonia lyase large subunit
GCU53_RS17345	COG4302	ethanolamine ammonia-lyase activity
GCU53_RS17360	COG1522	sequence-specific DNA binding
GCU53_RS17365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GCU53_RS17375	COG1643	Atp-dependent helicase
GCU53_RS17380	COG0501	Belongs to the peptidase M48B family
GCU53_RS17385	COG4269	membrane
GCU53_RS17400	COG0513	Belongs to the DEAD box helicase family
GCU53_RS17410	COG0045	succinate-CoA ligase (ADP-forming) activity
GCU53_RS17430	COG0123	including yeast histone deacetylase and acetoin utilization protein
GCU53_RS17460	COG2814	Major facilitator Superfamily
GCU53_RS17490	COG0628	permease
GCU53_RS17505	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GCU53_RS17520	COG2080	2 iron, 2 sulfur cluster binding
GCU53_RS17525	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GCU53_RS17530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GCU53_RS17535	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GCU53_RS17545	COG1858	cytochrome C peroxidase
GCU53_RS17560	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GCU53_RS17575	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GCU53_RS17580	COG3052	prosthetic group binding
GCU53_RS17600	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GCU53_RS17640	COG0745	RESPONSE REGULATOR receiver
GCU53_RS17660	COG2205	protein histidine kinase activity
GCU53_RS17675	COG1960	acyl-CoA dehydrogenase activity
GCU53_RS17680	COG1024	Enoyl-CoA hydratase
GCU53_RS17690	COG1024	Enoyl-CoA hydratase
GCU53_RS17700	COG0583	DNA-binding transcription factor activity
GCU53_RS17705	COG3719	Belongs to the RNase T2 family
GCU53_RS17710	COG3338	carbonate dehydratase activity
GCU53_RS17765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GCU53_RS17840	COG3039	Transposase
GCU53_RS17855	COG0628	permease
GCU53_RS17875	COG1294	oxidase, subunit
GCU53_RS17880	COG1271	oxidase subunit
GCU53_RS17885	COG2323	membrane
GCU53_RS17895	COG1028	Short-chain dehydrogenase reductase Sdr
GCU53_RS17900	COG3685	Protein conserved in bacteria
GCU53_RS17910	COG2204	response regulator
GCU53_RS17930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GCU53_RS17930	COG2010	Cytochrome c
GCU53_RS17935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GCU53_RS17950	COG3022	response to hydroperoxide
GCU53_RS17960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GCU53_RS17965	COG0315	cyclic pyranopterin monophosphate synthase activity
GCU53_RS17970	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GCU53_RS18000	COG2827	Endonuclease containing a URI domain
GCU53_RS18010	COG3081	Nucleoid-associated protein
GCU53_RS18020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GCU53_RS18030	COG0583	DNA-binding transcription factor activity
GCU53_RS18040	COG1028	Short-chain dehydrogenase reductase Sdr
GCU53_RS18050	COG0420	3'-5' exonuclease activity
GCU53_RS18055	COG0419	ATPase involved in DNA repair
GCU53_RS18070	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GCU53_RS18105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GCU53_RS18115	COG0795	lipopolysaccharide-transporting ATPase activity
GCU53_RS18120	COG0795	lipopolysaccharide-transporting ATPase activity
GCU53_RS18130	COG1278	Cold shock
GCU53_RS18150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GCU53_RS18155	COG0343	queuine tRNA-ribosyltransferase activity
GCU53_RS18160	COG1862	Preprotein translocase
GCU53_RS18200	COG1104	cysteine desulfurase activity
GCU53_RS18210	COG0316	Belongs to the HesB IscA family
GCU53_RS18215	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GCU53_RS18220	COG0443	Heat shock 70 kDa protein
GCU53_RS18235	COG0105	UTP biosynthetic process
GCU53_RS18255	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GCU53_RS18260	COG0124	histidyl-tRNA synthetase
GCU53_RS18265	COG2976	Protein conserved in bacteria
GCU53_RS18275	COG1160	GTP binding
GCU53_RS18285	COG0436	Aminotransferase
GCU53_RS18290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GCU53_RS18300	COG3293	Transposase
GCU53_RS18315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GCU53_RS18330	COG2356	endonuclease I
GCU53_RS18335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GCU53_RS18355	COG4993	Dehydrogenase
GCU53_RS18380	COG0371	Dehydrogenase
GCU53_RS18385	COG2909	trisaccharide binding
GCU53_RS18445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCU53_RS18450	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCU53_RS18465	COG0739	heme binding
GCU53_RS18475	COG1570	exodeoxyribonuclease VII activity
GCU53_RS18485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GCU53_RS18510	COG2132	Multicopper oxidase
GCU53_RS18520	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GCU53_RS18535	COG3034	peptidoglycan biosynthetic process
GCU53_RS18540	COG2816	NAD+ diphosphatase activity
GCU53_RS18545	COG0494	nUDIX hydrolase
GCU53_RS18555	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GCU53_RS18560	COG4536	flavin adenine dinucleotide binding
GCU53_RS18570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GCU53_RS18575	COG0228	four-way junction DNA binding
GCU53_RS18580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GCU53_RS18585	COG0336	Belongs to the RNA methyltransferase TrmD family
GCU53_RS18590	COG0335	large ribosomal subunit rRNA binding
GCU53_RS18595	COG1607	acyl-coa hydrolase
GCU53_RS18605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCU53_RS18625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GCU53_RS18630	COG3706	GGDEF domain
GCU53_RS18645	COG1902	pentaerythritol trinitrate reductase activity
GCU53_RS18660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GCU53_RS18685	COG1073	alpha beta
GCU53_RS18705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GCU53_RS18710	COG0563	adenylate kinase activity
GCU53_RS18715	COG1214	PFAM Peptidase M22, glycoprotease
GCU53_RS18720	COG1801	Protein of unknown function DUF72
GCU53_RS18730	COG0742	ribosomal rna small subunit methyltransferase
GCU53_RS18740	COG1131	(ABC) transporter
GCU53_RS18770	COG2226	methyltransferase
GCU53_RS18775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GCU53_RS18785	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GCU53_RS18795	COG2166	iron-sulfur cluster assembly
GCU53_RS18805	COG2171	N-acyltransferase activity
GCU53_RS18810	COG1393	Belongs to the ArsC family
GCU53_RS18815	COG3706	GGDEF domain
GCU53_RS18840	COG0025	NhaP-type Na H and K H
GCU53_RS18845	COG0436	Aminotransferase
GCU53_RS18850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GCU53_RS18855	COG0024	Methionine aminopeptidase
GCU53_RS18860	COG0052	Belongs to the universal ribosomal protein uS2 family
GCU53_RS18865	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GCU53_RS18870	COG0528	UMP kinase activity
GCU53_RS18875	COG0233	cytoplasmic translational termination
GCU53_RS18880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GCU53_RS18890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GCU53_RS18915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GCU53_RS18920	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GCU53_RS18925	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GCU53_RS18930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GCU53_RS18940	COG0825	malonyl-CoA metabolic process
GCU53_RS18950	COG0504	CTP synthase activity
GCU53_RS18955	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GCU53_RS18970	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GCU53_RS18975	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GCU53_RS18980	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GCU53_RS18985	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GCU53_RS18990	COG0585	pseudouridine synthase activity
GCU53_RS18995	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GCU53_RS19000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GCU53_RS19020	COG0840	transmembrane signaling receptor activity
GCU53_RS19030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GCU53_RS19035	COG1546	Belongs to the CinA family
GCU53_RS19040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GCU53_RS19045	COG2137	regulation of response to DNA damage stimulus
GCU53_RS19055	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GCU53_RS19060	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GCU53_RS19070	COG3148	PFAM DTW domain containing protein
GCU53_RS19080	COG0583	DNA-binding transcription factor activity
GCU53_RS19100	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GCU53_RS19100	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GCU53_RS19105	COG3706	GGDEF domain
GCU53_RS19115	COG0589	response to stress
GCU53_RS19130	COG0714	Associated with various cellular activities
GCU53_RS19155	COG2925	Exonuclease
GCU53_RS19170	COG0788	formyltetrahydrofolate deformylase activity
GCU53_RS19175	COG0583	DNA-binding transcription factor activity
GCU53_RS19180	COG3485	protocatechuate 3,4-dioxygenase
GCU53_RS19185	COG3485	protocatechuate 3,4-dioxygenase
GCU53_RS19190	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GCU53_RS19195	COG1414	Transcriptional regulator
GCU53_RS19200	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GCU53_RS19205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GCU53_RS19220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GCU53_RS19225	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GCU53_RS19230	COG0656	L-ascorbic acid biosynthetic process
GCU53_RS19235	COG1053	succinate dehydrogenase
GCU53_RS19250	COG1082	Xylose isomerase domain protein TIM barrel
GCU53_RS19250	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GCU53_RS19255	COG1309	transcriptional regulator
GCU53_RS19260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GCU53_RS19265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GCU53_RS19275	COG0582	viral genome integration into host DNA
GCU53_RS19305	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GCU53_RS19310	COG3657	addiction module killer protein
GCU53_RS19375	COG2831	hemolysin activation secretion protein
GCU53_RS19415	COG1902	pentaerythritol trinitrate reductase activity
GCU53_RS19425	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GCU53_RS19455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GCU53_RS19460	COG0693	protein deglycase activity
GCU53_RS19465	COG2308	Evidence 4 Homologs of previously reported genes of
GCU53_RS19480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GCU53_RS19510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GCU53_RS19515	COG0784	Response regulator, receiver
GCU53_RS19515	COG2205	protein histidine kinase activity
GCU53_RS19515	COG5002	protein histidine kinase activity
GCU53_RS19525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GCU53_RS19530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GCU53_RS19570	COG3956	TIGRFAM MazG family protein
GCU53_RS19580	COG3122	Protein conserved in bacteria
GCU53_RS19590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GCU53_RS19595	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GCU53_RS19605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GCU53_RS19610	COG0628	permease
GCU53_RS19615	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GCU53_RS19635	COG1295	ribonuclease BN
GCU53_RS19640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GCU53_RS19645	COG1254	Belongs to the acylphosphatase family
GCU53_RS19660	COG0442	prolyl-tRNA aminoacylation
GCU53_RS19670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GCU53_RS19680	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GCU53_RS19685	COG0632	four-way junction helicase activity
GCU53_RS19690	COG2255	four-way junction helicase activity
GCU53_RS19695	COG0824	Thioesterase
GCU53_RS19725	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GCU53_RS19730	COG0602	queuosine metabolic process
GCU53_RS19735	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GCU53_RS19755	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GCU53_RS19760	COG4783	chaperone-mediated protein folding
GCU53_RS19765	COG0425	Belongs to the sulfur carrier protein TusA family
GCU53_RS19770	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GCU53_RS19785	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GCU53_RS19790	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GCU53_RS19805	COG2226	methyltransferase
GCU53_RS19830	COG3174	membrane
GCU53_RS19835	COG2205	protein histidine kinase activity
GCU53_RS19860	COG0545	Peptidyl-prolyl cis-trans isomerase
GCU53_RS19865	COG3339	Conserved Protein
GCU53_RS19885	COG0604	alcohol dehydrogenase
GCU53_RS19885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GCU53_RS19885	COG3321	synthase
GCU53_RS19885	COG4221	oxidoreductase activity
GCU53_RS19890	COG1362	aminopeptidase activity
GCU53_RS19895	COG0564	pseudouridine synthase activity
GCU53_RS19900	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GCU53_RS19905	COG2894	cell division
GCU53_RS19910	COG0850	regulation of cytokinetic process
GCU53_RS19915	COG1560	Kdo2-lipid A biosynthetic process
GCU53_RS19920	COG2853	Lipoprotein
GCU53_RS19945	COG3162	membrane
GCU53_RS19950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GCU53_RS19960	COG3089	Belongs to the UPF0270 family
GCU53_RS19970	COG1363	Peptidase, m42
GCU53_RS19975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GCU53_RS19975	COG0189	ligase activity
GCU53_RS19980	COG0367	asparagine synthase
GCU53_RS19985	COG1846	Transcriptional regulator
GCU53_RS19990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GCU53_RS19990	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GCU53_RS20025	COG0271	Belongs to the BolA IbaG family
GCU53_RS20080	COG3039	Transposase
GCU53_RS20130	COG2154	pterin-4-alpha-carbinolamine dehydratase
GCU53_RS20170	COG2301	Belongs to the HpcH HpaI aldolase family
GCU53_RS20175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GCU53_RS20190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GCU53_RS20210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GCU53_RS20220	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GCU53_RS20245	COG2239	Acts as a magnesium transporter
GCU53_RS20280	COG0745	RESPONSE REGULATOR receiver
GCU53_RS20290	COG0800	Aldolase
GCU53_RS20300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GCU53_RS20320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GCU53_RS20355	COG0135	phosphoribosylanthranilate isomerase activity
GCU53_RS20360	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GCU53_RS20365	COG0285	dihydrofolate synthase activity
GCU53_RS20375	COG1286	toxin biosynthetic process
GCU53_RS20425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GCU53_RS20430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GCU53_RS20435	COG0705	Rhomboid family
GCU53_RS20475	COG0642	Histidine kinase
GCU53_RS20485	COG2900	Belongs to the SlyX family
GCU53_RS20490	COG1278	Cold shock
GCU53_RS20495	COG3139	Protein of unknown function (DUF1315)
GCU53_RS20505	COG0308	aminopeptidase N
GCU53_RS20510	COG0427	acetyl-CoA hydrolase
GCU53_RS20540	COG0714	Associated with various cellular activities
GCU53_RS20570	COG0167	dihydroorotate dehydrogenase activity
GCU53_RS20575	COG3130	regulation of translation
GCU53_RS20585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GCU53_RS20585	COG0116	Belongs to the methyltransferase superfamily
GCU53_RS20590	COG2027	D-alanyl-D-alanine carboxypeptidase
GCU53_RS20625	COG1525	nuclease
GCU53_RS20655	COG1857	crispr-associated protein
GCU53_RS20700	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GCU53_RS20710	COG0513	Belongs to the DEAD box helicase family
GCU53_RS20715	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GCU53_RS20720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GCU53_RS20725	COG5265	(ABC) transporter
GCU53_RS20820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GCU53_RS20830	COG4659	FMN binding
GCU53_RS20835	COG4658	electron transport chain
GCU53_RS20845	COG2878	Part of a membrane complex involved in electron transport
GCU53_RS20850	COG4657	Part of a membrane complex involved in electron transport
GCU53_RS20855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCU53_RS20855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCU53_RS20860	COG0489	protein tyrosine kinase activity
GCU53_RS20900	COG0717	Belongs to the dCTP deaminase family
GCU53_RS20955	COG3436	PFAM IS66 Orf2 family protein
GCU53_RS20960	COG2433	Pfam Transposase IS66
GCU53_RS20970	COG3012	SEC-C Motif Domain Protein
GCU53_RS20990	COG1199	ATP-dependent helicase activity
GCU53_RS20995	COG1320	monovalent cation:proton antiporter activity
GCU53_RS21000	COG2212	antiporter activity
GCU53_RS21005	COG1863	multisubunit Na H antiporter MnhE subunit
GCU53_RS21010	COG0651	ATP synthesis coupled electron transport
GCU53_RS21015	COG1006	Multisubunit Na H antiporter MnhC subunit
GCU53_RS21020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GCU53_RS21020	COG2111	Na H antiporter
GCU53_RS21030	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GCU53_RS21035	COG2885	chlorophyll binding
GCU53_RS21040	COG0259	pyridoxamine-phosphate oxidase activity
GCU53_RS21050	COG3133	Outer membrane lipoprotein
GCU53_RS21055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GCU53_RS21055	COG2111	Na H antiporter
GCU53_RS21060	COG1006	Multisubunit Na H antiporter MnhC subunit
GCU53_RS21065	COG0651	ATP synthesis coupled electron transport
GCU53_RS21075	COG2212	antiporter activity
GCU53_RS21080	COG1320	monovalent cation:proton antiporter activity
GCU53_RS21130	COG3639	organic phosphonate transmembrane transporter activity
GCU53_RS21140	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GCU53_RS21150	COG3622	Belongs to the hyi family
GCU53_RS21170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GCU53_RS21175	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GCU53_RS21180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GCU53_RS21195	COG1294	oxidase, subunit
GCU53_RS21210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GCU53_RS21240	COG0348	domain, Protein
GCU53_RS21245	COG2010	Cytochrome c
GCU53_RS21260	COG3278	Belongs to the heme-copper respiratory oxidase family
GCU53_RS21280	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GCU53_RS21290	COG1555	photosystem II stabilization
GCU53_RS21310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GCU53_RS21315	COG0668	transmembrane transport
GCU53_RS21320	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GCU53_RS21330	COG0564	pseudouridine synthase activity
GCU53_RS21335	COG0071	Belongs to the small heat shock protein (HSP20) family
GCU53_RS21355	COG1028	Short-chain dehydrogenase reductase Sdr
GCU53_RS21360	COG1414	Transcriptional regulator
GCU53_RS21365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GCU53_RS21370	COG1053	succinate dehydrogenase
GCU53_RS21380	COG1053	succinate dehydrogenase
GCU53_RS21405	COG1063	alcohol dehydrogenase
GCU53_RS21425	COG1028	Short-chain dehydrogenase reductase Sdr
GCU53_RS21430	COG1053	succinate dehydrogenase
GCU53_RS21440	COG2814	Major facilitator Superfamily
GCU53_RS21465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GCU53_RS21485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GCU53_RS21495	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GCU53_RS21500	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GCU53_RS21505	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GCU53_RS21510	COG0072	phenylalanine-tRNA ligase activity
GCU53_RS21515	COG0776	regulation of translation
GCU53_RS21680	COG1475	DNA binding
GCU53_RS21740	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
GCU53_RS21755	COG1598	PFAM Uncharacterised protein family UPF0150
GCU53_RS21760	COG1724	mRNA binding
GCU53_RS21930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GCU53_RS21935	COG4396	Host-nuclease inhibitor protein Gam
GCU53_RS21950	COG0145	ligase activity
GCU53_RS21955	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
GCU53_RS21960	COG4647	ligase activity
GCU53_RS21975	COG0515	serine threonine protein kinase
GCU53_RS21995	COG1045	serine acetyltransferase
GCU53_RS22000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GCU53_RS22005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GCU53_RS22020	COG1024	Enoyl-CoA hydratase
GCU53_RS22030	COG1012	belongs to the aldehyde dehydrogenase family
GCU53_RS22045	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
GCU53_RS22050	COG4266	Belongs to the allantoicase family
GCU53_RS22075	COG4566	intracellular signal transduction
GCU53_RS22090	COG0318	PFAM AMP-dependent synthetase and ligase
GCU53_RS22095	COG0402	S-adenosylhomocysteine deaminase activity
GCU53_RS22105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GCU53_RS22115	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GCU53_RS22135	COG0667	Aldo Keto reductase
GCU53_RS22140	COG0625	glutathione transferase activity
GCU53_RS22145	COG2175	clavaminate synthase activity
GCU53_RS22150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GCU53_RS22160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GCU53_RS22185	COG3265	gluconokinase activity
GCU53_RS22200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GCU53_RS22205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GCU53_RS22210	COG1116	anion transmembrane transporter activity
GCU53_RS22210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GCU53_RS22230	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GCU53_RS22235	COG0625	glutathione transferase activity
GCU53_RS22265	COG2217	Heavy metal translocating P-type atpase
GCU53_RS22275	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GCU53_RS22295	COG0783	Belongs to the Dps family
GCU53_RS22340	COG3409	Peptidoglycan-binding domain 1 protein
GCU53_RS22340	COG3267	Type II secretory pathway component ExeA
GCU53_RS22360	COG0714	Associated with various cellular activities
GCU53_RS22395	COG1469	GTP cyclohydrolase I activity
GCU53_RS22415	COG0084	hydrolase, TatD family'
GCU53_RS22420	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GCU53_RS22435	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GCU53_RS22440	COG4181	ATPase activity
GCU53_RS22490	COG0189	ligase activity
GCU53_RS22505	COG1802	Transcriptional regulator
GCU53_RS22530	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GCU53_RS22540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GCU53_RS22550	COG0668	transmembrane transport
GCU53_RS22570	COG0243	molybdopterin cofactor binding
GCU53_RS22575	COG2146	nitrite reductase [NAD(P)H] activity
GCU53_RS22580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GCU53_RS22585	COG2815	serine threonine protein kinase
GCU53_RS22585	COG0515	serine threonine protein kinase
GCU53_RS22590	COG2223	nitrite transmembrane transporter activity
GCU53_RS22610	COG0436	Aminotransferase
GCU53_RS22625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GCU53_RS22645	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GCU53_RS22650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GCU53_RS22655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GCU53_RS22660	COG0215	cysteine-tRNA ligase activity
GCU53_RS22665	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GCU53_RS22685	COG4974	Belongs to the 'phage' integrase family
GCU53_RS22730	COG2433	Pfam Transposase IS66
GCU53_RS22735	COG3436	PFAM IS66 Orf2 family protein
GCU53_RS22765	COG2026	Addiction module toxin, RelE StbE family
GCU53_RS22800	COG2932	Transcriptional regulator
GCU53_RS22825	COG3756	Protein conserved in bacteria
GCU53_RS22915	COG4386	tail sheath protein
GCU53_RS22960	COG3299	homolog of phage Mu protein gp47
GCU53_RS23025	COG0544	peptidyl-prolyl cis-trans isomerase activity
GCU53_RS23035	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GCU53_RS23040	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GCU53_RS23050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GCU53_RS23055	COG3243	poly(R)-hydroxyalkanoic acid synthase
GCU53_RS23065	COG1028	Short-chain dehydrogenase reductase Sdr
GCU53_RS23080	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
GCU53_RS23085	COG0302	gtp cyclohydrolase
GCU53_RS23100	COG1335	isochorismatase
GCU53_RS23115	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GCU53_RS23125	COG0235	Class ii aldolase
GCU53_RS23135	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
GCU53_RS23150	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GCU53_RS23170	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GCU53_RS23190	COG0582	viral genome integration into host DNA
GCU53_RS23245	COG0419	ATPase involved in DNA repair
GCU53_RS23365	COG0305	Participates in initiation and elongation during chromosome replication
GCU53_RS23370	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
GCU53_RS23480	COG4386	tail sheath protein
GCU53_RS23590	COG2184	nucleotidyltransferase activity
GCU53_RS23655	COG0582	viral genome integration into host DNA
GCU53_RS23690	COG3293	Transposase
GCU53_RS23700	COG1741	Belongs to the pirin family
GCU53_RS23740	COG3077	Addiction module antitoxin, RelB DinJ family
GCU53_RS23750	COG2337	Toxic component of a toxin-antitoxin (TA) module
GCU53_RS23755	COG2336	PFAM SpoVT AbrB
GCU53_RS23775	COG5654	RES domain protein
GCU53_RS23780	COG5642	Protein of unknown function (DUF2384)
GCU53_RS23790	COG0488	(ABC) transporter
GCU53_RS23850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GCU53_RS23865	COG2433	Pfam Transposase IS66
GCU53_RS23870	COG3436	PFAM IS66 Orf2 family protein
GCU53_RS23880	COG0583	DNA-binding transcription factor activity
GCU53_RS23885	COG1028	Short-chain dehydrogenase reductase Sdr
GCU53_RS23925	COG4453	Protein conserved in bacteria
GCU53_RS23930	COG0583	DNA-binding transcription factor activity
GCU53_RS23940	COG2814	Major facilitator Superfamily
GCU53_RS23975	COG5642	Protein of unknown function (DUF2384)
GCU53_RS23980	COG5654	RES domain protein
GCU53_RS24050	COG2176	DNA-directed DNA polymerase activity
GCU53_RS24070	COG4680	protein conserved in bacteria
GCU53_RS24085	COG1475	DNA binding
GCU53_RS24090	COG1192	Involved in chromosome partitioning
GCU53_RS24155	COG3293	Transposase
GCU53_RS24170	COG3039	Transposase
GCU53_RS24195	COG1061	Type III restriction enzyme res subunit
GCU53_RS24200	COG0210	DNA helicase
GCU53_RS24225	COG1028	Short-chain dehydrogenase reductase Sdr
GCU53_RS24230	COG1082	Xylose isomerase domain protein TIM barrel
GCU53_RS24235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GCU53_RS24240	COG3959	Transketolase, thiamine diphosphate binding domain
GCU53_RS24255	COG1028	Short-chain dehydrogenase reductase Sdr
GCU53_RS24410	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GCU53_RS24520	COG3039	Transposase
GCU53_RS24525	COG3039	Transposase
GCU53_RS24580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GCU53_RS24585	COG3436	PFAM IS66 Orf2 family protein
GCU53_RS24595	COG3344	reverse transcriptase
GCU53_RS24610	COG3344	reverse transcriptase
GCU53_RS24625	COG2356	endonuclease I
GCU53_RS24640	COG0210	DNA helicase
GCU53_RS24680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GCU53_RS24685	COG0475	glutathione-regulated potassium exporter activity
GCU53_RS24695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GCU53_RS24700	COG3293	Transposase
GCU53_RS24745	COG2169	Transcriptional regulator
GCU53_RS24745	COG1917	Cupin 2, conserved barrel domain protein
GCU53_RS24840	COG0183	Belongs to the thiolase family
GCU53_RS24870	COG0318	PFAM AMP-dependent synthetase and ligase
GCU53_RS24875	COG1028	Short-chain dehydrogenase reductase Sdr
GCU53_RS24925	COG1335	isochorismatase
GCU53_RS24935	COG0667	Aldo Keto reductase
GCU53_RS24940	COG1902	pentaerythritol trinitrate reductase activity
GCU53_RS24965	COG1028	Short-chain dehydrogenase reductase Sdr
GCU53_RS24975	COG0583	DNA-binding transcription factor activity
GCU53_RS25115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GCU53_RS25120	COG0667	Aldo Keto reductase
GCU53_RS25125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GCU53_RS25150	COG3039	Transposase
GCU53_RS25180	COG3293	Transposase
GCU53_RS25185	COG3311	Transcriptional regulator
GCU53_RS25190	COG1569	PIN domain
GCU53_RS25245	COG2026	Addiction module toxin, RelE StbE family
GCU53_RS25260	COG1741	Belongs to the pirin family
GCU53_RS25275	COG2176	DNA-directed DNA polymerase activity
GCU53_RS25335	COG3321	synthase
GCU53_RS25335	COG0604	alcohol dehydrogenase