locus-tag	class	description
AVCA_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AVCA_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AVCA_RS00040	COG2837	iron assimilation
AVCA_RS00055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AVCA_RS00060	COG0751	glycine-tRNA ligase activity
AVCA_RS00070	COG2818	Glycosylase
AVCA_RS00075	COG0737	Belongs to the 5'-nucleotidase family
AVCA_RS00075	COG1525	nuclease
AVCA_RS00075	COG4085	toxin activity
AVCA_RS00080	COG0569	domain protein
AVCA_RS00085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AVCA_RS00095	COG0242	peptide deformylase activity
AVCA_RS00105	COG0758	DNA mediated transformation
AVCA_RS00110	COG0009	L-threonylcarbamoyladenylate synthase
AVCA_RS00120	COG0408	coproporphyrinogen oxidase activity
AVCA_RS00125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVCA_RS00140	COG2132	Multicopper oxidase
AVCA_RS00150	COG1285	pathogenesis
AVCA_RS00195	COG0655	NAD(P)H dehydrogenase (quinone) activity
AVCA_RS00200	COG0700	Nucleoside recognition
AVCA_RS00215	COG3706	GGDEF domain
AVCA_RS00245	COG1126	abc transporter atp-binding protein
AVCA_RS00260	COG0210	DNA helicase
AVCA_RS00270	COG0826	peptidase U32
AVCA_RS00285	COG0842	Transport permease protein
AVCA_RS00290	COG0842	Transport permease protein
AVCA_RS00295	COG1131	(ABC) transporter
AVCA_RS00305	COG1309	transcriptional regulator
AVCA_RS00325	COG2945	thiolester hydrolase activity
AVCA_RS00325	COG0596	Alpha beta hydrolase
AVCA_RS00360	COG0675	Transposase, IS605 OrfB family
AVCA_RS00380	COG1335	isochorismatase
AVCA_RS00395	COG1305	Transglutaminase-like
AVCA_RS00400	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AVCA_RS00405	COG0735	belongs to the Fur family
AVCA_RS00410	COG1121	(ABC) transporter
AVCA_RS00415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AVCA_RS00455	COG0109	protoheme IX farnesyltransferase activity
AVCA_RS00460	COG1612	heme a metabolic process
AVCA_RS00485	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AVCA_RS00490	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVCA_RS00505	COG0659	secondary active sulfate transmembrane transporter activity
AVCA_RS00535	COG3712	iron ion homeostasis
AVCA_RS00545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AVCA_RS00570	COG0252	asparaginase activity
AVCA_RS00590	COG1686	Belongs to the peptidase S11 family
AVCA_RS00605	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AVCA_RS00630	COG2814	Major facilitator Superfamily
AVCA_RS00635	COG0318	PFAM AMP-dependent synthetase and ligase
AVCA_RS00635	COG0204	Acyl-transferase
AVCA_RS00715	COG3411	Ferredoxin
AVCA_RS00815	COG0523	cobalamin synthesis protein
AVCA_RS00825	COG1607	acyl-coa hydrolase
AVCA_RS00835	COG1283	sodium-dependent phosphate transmembrane transporter activity
AVCA_RS00845	COG1764	response to oxidative stress
AVCA_RS00905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVCA_RS00950	COG3023	N-Acetylmuramoyl-L-alanine amidase
AVCA_RS00970	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AVCA_RS00975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AVCA_RS00985	COG0583	DNA-binding transcription factor activity
AVCA_RS00990	COG0439	Biotin carboxylase
AVCA_RS00995	COG5016	pyruvate
AVCA_RS00995	COG0511	ligase activity, forming carbon-carbon bonds
AVCA_RS01000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA_RS01020	COG0133	tryptophan synthase activity
AVCA_RS01025	COG0159	tryptophan synthase activity
AVCA_RS01045	COG0484	heat shock protein binding
AVCA_RS01050	COG0789	Transcriptional regulator
AVCA_RS01055	COG0730	response to heat
AVCA_RS01080	COG1595	DNA-templated transcription, initiation
AVCA_RS01105	COG2356	endonuclease I
AVCA_RS01115	COG3237	CsbD-like
AVCA_RS01125	COG0789	Transcriptional regulator
AVCA_RS01140	COG2982	Protein involved in outer membrane biogenesis
AVCA_RS01150	COG0778	Nitroreductase
AVCA_RS01155	COG0577	efflux transmembrane transporter activity
AVCA_RS01155	COG1136	(ABC) transporter
AVCA_RS01180	COG0366	Alpha amylase catalytic
AVCA_RS01200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AVCA_RS01205	COG2841	Protein conserved in bacteria
AVCA_RS01220	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AVCA_RS01225	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AVCA_RS01275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AVCA_RS01320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AVCA_RS01325	COG1758	RNA polymerase activity
AVCA_RS01335	COG1561	YicC-like family, N-terminal region
AVCA_RS01340	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AVCA_RS01350	COG0708	Exodeoxyribonuclease III
AVCA_RS01355	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AVCA_RS01365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AVCA_RS01375	COG0756	dUTP diphosphatase activity
AVCA_RS01380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AVCA_RS01385	COG2003	Belongs to the UPF0758 family
AVCA_RS01390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AVCA_RS01395	COG2363	Small membrane protein
AVCA_RS01405	COG2022	thiamine diphosphate biosynthetic process
AVCA_RS01410	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AVCA_RS01415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AVCA_RS01430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVCA_RS01430	COG2813	Specifically methylates the guanine in position
AVCA_RS01435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVCA_RS01440	COG1872	DUF167
AVCA_RS01475	COG0540	Belongs to the ATCase OTCase family
AVCA_RS01485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AVCA_RS01510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AVCA_RS01530	COG3038	cytochrome b561
AVCA_RS01535	COG2353	YceI-like domain
AVCA_RS01545	COG2205	protein histidine kinase activity
AVCA_RS01560	COG0129	dihydroxy-acid dehydratase activity
AVCA_RS01575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AVCA_RS01580	COG0842	Transport permease protein
AVCA_RS01585	COG1131	(ABC) transporter
AVCA_RS01590	COG0840	transmembrane signaling receptor activity
AVCA_RS01595	COG0693	protein deglycase activity
AVCA_RS01600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AVCA_RS01630	COG0247	lactate metabolic process
AVCA_RS01640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AVCA_RS01645	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AVCA_RS01650	COG0429	hydrolase of the alpha beta-hydrolase fold
AVCA_RS01655	COG0742	ribosomal rna small subunit methyltransferase
AVCA_RS01660	COG0612	Peptidase, M16
AVCA_RS01665	COG0612	Peptidase, M16
AVCA_RS01670	COG0513	Belongs to the DEAD box helicase family
AVCA_RS01675	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AVCA_RS01690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AVCA_RS01695	COG0738	Major facilitator superfamily
AVCA_RS01705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVCA_RS01765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA_RS01770	COG2814	Major facilitator Superfamily
AVCA_RS01775	COG1902	pentaerythritol trinitrate reductase activity
AVCA_RS01780	COG0583	DNA-binding transcription factor activity
AVCA_RS01785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AVCA_RS01790	COG3383	formate dehydrogenase (NAD+) activity
AVCA_RS01790	COG0243	molybdopterin cofactor binding
AVCA_RS01795	COG0437	4 iron, 4 sulfur cluster binding
AVCA_RS01800	COG2864	formate dehydrogenase
AVCA_RS01815	COG1595	DNA-templated transcription, initiation
AVCA_RS01875	COG0583	DNA-binding transcription factor activity
AVCA_RS01930	COG0346	lactoylglutathione lyase activity
AVCA_RS01960	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
AVCA_RS02035	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVCA_RS02050	COG2194	sulfuric ester hydrolase activity
AVCA_RS02080	COG1151	hydroxylamine reductase activity
AVCA_RS02100	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AVCA_RS02105	COG1194	a g-specific adenine glycosylase
AVCA_RS02120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AVCA_RS02130	COG0131	Imidazoleglycerol-phosphate dehydratase
AVCA_RS02135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AVCA_RS02145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AVCA_RS02150	COG0107	imidazoleglycerol-phosphate synthase activity
AVCA_RS02155	COG0793	Belongs to the peptidase S41A family
AVCA_RS02160	COG4942	peptidase
AVCA_RS02165	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AVCA_RS02180	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AVCA_RS02185	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AVCA_RS02195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVCA_RS02210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AVCA_RS02210	COG3218	ABC-type transport auxiliary lipoprotein component
AVCA_RS02215	COG1127	ABC transporter
AVCA_RS02220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AVCA_RS02225	COG3132	Protein of unknown function, DUF480
AVCA_RS02240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AVCA_RS02260	COG0306	phosphate transporter
AVCA_RS02275	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AVCA_RS02275	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AVCA_RS02285	COG5001	Diguanylate cyclase
AVCA_RS02285	COG5002	protein histidine kinase activity
AVCA_RS02285	COG3447	MASE1 domain protein
AVCA_RS02320	COG2918	glutathione biosynthetic process
AVCA_RS02330	COG2183	response to ionizing radiation
AVCA_RS02335	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AVCA_RS02345	COG0457	Tetratricopeptide repeat
AVCA_RS02375	COG0189	ligase activity
AVCA_RS02380	COG4067	protein conserved in archaea
AVCA_RS02380	COG0189	ligase activity
AVCA_RS02385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AVCA_RS02400	COG1012	belongs to the aldehyde dehydrogenase family
AVCA_RS02405	COG2186	Transcriptional regulator
AVCA_RS02410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVCA_RS02415	COG2271	Major facilitator Superfamily
AVCA_RS02420	COG2721	sulfolactate sulfo-lyase activity
AVCA_RS02425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVCA_RS02510	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AVCA_RS02530	COG1011	Hydrolase
AVCA_RS02535	COG0494	nUDIX hydrolase
AVCA_RS02540	COG1218	3'(2'),5'-bisphosphate nucleotidase
AVCA_RS02550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AVCA_RS02555	COG2226	methyltransferase
AVCA_RS02570	COG0126	phosphoglycerate kinase activity
AVCA_RS02580	COG4702	Belongs to the UPF0303 family
AVCA_RS02585	COG0673	inositol 2-dehydrogenase activity
AVCA_RS02590	COG1349	DNA-binding transcription factor activity
AVCA_RS02595	COG1451	nucleotide metabolic process
AVCA_RS02605	COG2354	Protein conserved in bacteria
AVCA_RS02620	COG1289	transmembrane transporter activity
AVCA_RS02630	COG0330	HflC and HflK could
AVCA_RS02635	COG0686	Belongs to the AlaDH PNT family
AVCA_RS02640	COG1309	transcriptional regulator
AVCA_RS02650	COG0625	glutathione transferase activity
AVCA_RS02660	COG2814	Major facilitator Superfamily
AVCA_RS02685	COG0204	Acyl-transferase
AVCA_RS02695	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AVCA_RS02735	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AVCA_RS02740	COG1040	competence protein
AVCA_RS02745	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AVCA_RS02750	COG0156	8-amino-7-oxononanoate synthase activity
AVCA_RS02755	COG2226	methyltransferase
AVCA_RS02755	COG1073	alpha beta
AVCA_RS02765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AVCA_RS02775	COG4589	Belongs to the CDS family
AVCA_RS02780	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AVCA_RS02780	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AVCA_RS02785	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AVCA_RS02830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AVCA_RS02835	COG0081	regulation of translation
AVCA_RS02840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AVCA_RS02845	COG0222	ribosome binding
AVCA_RS02850	COG0085	RNA polymerase activity
AVCA_RS02855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AVCA_RS02860	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AVCA_RS02865	COG0049	tRNA binding
AVCA_RS02880	COG0051	transcription antitermination factor activity, RNA binding
AVCA_RS02885	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AVCA_RS02890	COG0088	Forms part of the polypeptide exit tunnel
AVCA_RS02895	COG0089	rRNA binding
AVCA_RS02900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AVCA_RS02905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AVCA_RS02910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AVCA_RS02915	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AVCA_RS02920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AVCA_RS02925	COG0255	Belongs to the universal ribosomal protein uL29 family
AVCA_RS02930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AVCA_RS02935	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AVCA_RS02940	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AVCA_RS02945	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AVCA_RS02950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AVCA_RS02955	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AVCA_RS02960	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AVCA_RS02965	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AVCA_RS02970	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AVCA_RS02975	COG1841	ribosomal large subunit assembly
AVCA_RS02980	COG0200	Binds to the 23S rRNA
AVCA_RS02990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AVCA_RS02995	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AVCA_RS03005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AVCA_RS03010	COG0202	RNA polymerase activity
AVCA_RS03015	COG0203	ribosomal protein L17
AVCA_RS03025	COG2814	Major facilitator Superfamily
AVCA_RS03035	COG0583	DNA-binding transcription factor activity
AVCA_RS03040	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS03050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVCA_RS03055	COG3047	cAMP biosynthetic process
AVCA_RS03060	COG3047	cAMP biosynthetic process
AVCA_RS03075	COG4181	ATPase activity
AVCA_RS03090	COG3118	belongs to the thioredoxin family
AVCA_RS03095	COG2264	protein methyltransferase activity
AVCA_RS03105	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AVCA_RS03110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVCA_RS03110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVCA_RS03125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AVCA_RS03135	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AVCA_RS03140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AVCA_RS03150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVCA_RS03155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVCA_RS03165	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AVCA_RS03175	COG0443	Heat shock 70 kDa protein
AVCA_RS03190	COG0138	bifunctional purine biosynthesis protein purh
AVCA_RS03210	COG2264	protein methyltransferase activity
AVCA_RS03245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVCA_RS03260	COG0023	Translation Initiation Factor
AVCA_RS03265	COG1166	arginine decarboxylase activity
AVCA_RS03270	COG0534	Mate efflux family protein
AVCA_RS03280	COG0589	response to stress
AVCA_RS03290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AVCA_RS03345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVCA_RS03360	COG1126	abc transporter atp-binding protein
AVCA_RS03365	COG0765	amino acid transport
AVCA_RS03370	COG0765	amino acid transport
AVCA_RS03380	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AVCA_RS03385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AVCA_RS03410	COG3830	Belongs to the UPF0237 family
AVCA_RS03410	COG0560	Phosphoserine phosphatase
AVCA_RS03415	COG1063	alcohol dehydrogenase
AVCA_RS03420	COG0688	phosphatidylethanolamine metabolic process
AVCA_RS03430	COG1162	GTPase activity
AVCA_RS03435	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AVCA_RS03445	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AVCA_RS03445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AVCA_RS03450	COG0802	atpase or kinase
AVCA_RS03455	COG0860	N-Acetylmuramoyl-L-alanine amidase
AVCA_RS03460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AVCA_RS03465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AVCA_RS03470	COG1923	regulation of RNA biosynthetic process
AVCA_RS03475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AVCA_RS03480	COG0330	HflC and HflK could
AVCA_RS03485	COG0330	HflC and HflK could
AVCA_RS03495	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AVCA_RS03500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AVCA_RS03515	COG0557	exoribonuclease II activity
AVCA_RS03520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVCA_RS03525	COG0360	Binds together with S18 to 16S ribosomal RNA
AVCA_RS03530	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AVCA_RS03540	COG0359	binds to the 23S rRNA
AVCA_RS03545	COG0305	Participates in initiation and elongation during chromosome replication
AVCA_RS03560	COG2813	Specifically methylates the guanine in position
AVCA_RS03570	COG1946	Acyl-CoA thioesterase
AVCA_RS03575	COG0546	phosphoglycolate phosphatase activity
AVCA_RS03580	COG2321	neutral zinc metallopeptidase
AVCA_RS03595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AVCA_RS03600	COG2252	PERMEase
AVCA_RS03605	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AVCA_RS03620	COG4206	TonB-dependent receptor
AVCA_RS03625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AVCA_RS03630	COG0142	geranyltranstransferase activity
AVCA_RS03635	COG1722	exodeoxyribonuclease VII activity
AVCA_RS03640	COG3300	MHYT domain
AVCA_RS03640	COG5001	Diguanylate cyclase
AVCA_RS03655	COG3228	Belongs to the MtfA family
AVCA_RS03670	COG1454	alcohol dehydrogenase
AVCA_RS03680	COG3284	Transcriptional regulator
AVCA_RS03685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AVCA_RS03720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVCA_RS03725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA_RS03735	COG4771	TonB-dependent receptor
AVCA_RS03745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA_RS03755	COG4771	TonB-dependent receptor
AVCA_RS03790	COG0702	epimerase
AVCA_RS03800	COG1346	cytolysis
AVCA_RS03810	COG0366	Alpha amylase catalytic
AVCA_RS03815	COG0586	Pfam SNARE associated Golgi protein
AVCA_RS03820	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AVCA_RS03825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AVCA_RS03835	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AVCA_RS03840	COG0768	penicillin binding
AVCA_RS03845	COG0772	Belongs to the SEDS family
AVCA_RS03850	COG2951	lytic endotransglycosylase activity
AVCA_RS03860	COG1686	Belongs to the peptidase S11 family
AVCA_RS03865	COG2921	Belongs to the UPF0250 family
AVCA_RS03870	COG0321	lipoyl(octanoyl) transferase activity
AVCA_RS03875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AVCA_RS03880	COG0028	Belongs to the TPP enzyme family
AVCA_RS03885	COG2951	lytic endotransglycosylase activity
AVCA_RS03900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVCA_RS03940	COG2814	Major facilitator Superfamily
AVCA_RS03965	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AVCA_RS03985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVCA_RS04095	COG0495	leucyl-tRNA aminoacylation
AVCA_RS04105	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AVCA_RS04110	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AVCA_RS04120	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AVCA_RS04125	COG1702	phosphate starvation-inducible protein PhoH
AVCA_RS04135	COG2801	Transposase and inactivated derivatives
AVCA_RS04135	COG3415	Transposase
AVCA_RS04150	COG3254	rhamnose metabolic process
AVCA_RS04170	COG4580	involved in the transport of maltose and maltodextrins
AVCA_RS04175	COG2271	Major facilitator Superfamily
AVCA_RS04180	COG4948	Mandelate Racemase Muconate Lactonizing
AVCA_RS04190	COG1012	belongs to the aldehyde dehydrogenase family
AVCA_RS04200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AVCA_RS04205	COG0352	thiamine-phosphate diphosphorylase activity
AVCA_RS04210	COG0351	phosphomethylpyrimidine kinase
AVCA_RS04215	COG1960	acyl-CoA dehydrogenase activity
AVCA_RS04220	COG0019	diaminopimelate decarboxylase activity
AVCA_RS04230	COG2814	Major facilitator Superfamily
AVCA_RS04235	COG4264	IucA IucC family
AVCA_RS04245	COG4772	TonB-dependent receptor
AVCA_RS04255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AVCA_RS04260	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AVCA_RS04265	COG0830	nickel cation binding
AVCA_RS04270	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AVCA_RS04275	COG0673	inositol 2-dehydrogenase activity
AVCA_RS04285	COG1301	dicarboxylic acid transport
AVCA_RS04290	COG0596	Alpha beta hydrolase
AVCA_RS04295	COG0583	DNA-binding transcription factor activity
AVCA_RS04330	COG3293	Transposase
AVCA_RS04365	COG1021	2,3-dihydroxybenzoate-AMP ligase
AVCA_RS04370	COG3433	isochorismatase activity
AVCA_RS04370	COG1535	isochorismatase
AVCA_RS04390	COG2801	Transposase and inactivated derivatives
AVCA_RS04410	COG0066	3-isopropylmalate dehydratase activity
AVCA_RS04415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AVCA_RS04440	COG0804	urea catabolic process
AVCA_RS04445	COG0832	Belongs to the urease beta subunit family
AVCA_RS04450	COG0831	urea catabolic process
AVCA_RS04455	COG0829	nickel cation binding
AVCA_RS04460	COG4303	Ethanolamine ammonia lyase large subunit
AVCA_RS04465	COG4302	ethanolamine ammonia-lyase activity
AVCA_RS04480	COG1522	sequence-specific DNA binding
AVCA_RS04485	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AVCA_RS04495	COG1643	Atp-dependent helicase
AVCA_RS04505	COG0513	Belongs to the DEAD box helicase family
AVCA_RS04510	COG0493	'glutamate synthase
AVCA_RS04510	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AVCA_RS04515	COG0123	including yeast histone deacetylase and acetoin utilization protein
AVCA_RS04540	COG1309	transcriptional regulator
AVCA_RS04545	COG2814	Major facilitator Superfamily
AVCA_RS04575	COG0628	permease
AVCA_RS04590	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AVCA_RS04605	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AVCA_RS04610	COG1858	cytochrome C peroxidase
AVCA_RS04625	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AVCA_RS04640	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AVCA_RS04645	COG3052	prosthetic group binding
AVCA_RS04665	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AVCA_RS04695	COG1368	sulfuric ester hydrolase activity
AVCA_RS04700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AVCA_RS04705	COG4774	siderophore transport
AVCA_RS04720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AVCA_RS04720	COG4651	solute:proton antiporter activity
AVCA_RS04760	COG0745	RESPONSE REGULATOR receiver
AVCA_RS04765	COG2205	protein histidine kinase activity
AVCA_RS04770	COG0306	phosphate transporter
AVCA_RS04780	COG0848	biopolymer transport protein
AVCA_RS04800	COG0583	DNA-binding transcription factor activity
AVCA_RS04805	COG1960	acyl-CoA dehydrogenase activity
AVCA_RS04810	COG1024	Enoyl-CoA hydratase
AVCA_RS04820	COG1024	Enoyl-CoA hydratase
AVCA_RS04830	COG0583	DNA-binding transcription factor activity
AVCA_RS04835	COG3719	Belongs to the RNase T2 family
AVCA_RS04870	COG3223	Belongs to the PsiE family
AVCA_RS04875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AVCA_RS04880	COG3293	Transposase
AVCA_RS04960	COG0628	permease
AVCA_RS04975	COG1294	oxidase, subunit
AVCA_RS04980	COG1271	oxidase subunit
AVCA_RS04985	COG2323	membrane
AVCA_RS04995	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS05000	COG3685	Protein conserved in bacteria
AVCA_RS05010	COG2204	response regulator
AVCA_RS05030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AVCA_RS05030	COG2010	Cytochrome c
AVCA_RS05035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVCA_RS05055	COG3022	response to hydroperoxide
AVCA_RS05065	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AVCA_RS05070	COG0315	cyclic pyranopterin monophosphate synthase activity
AVCA_RS05075	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AVCA_RS05095	COG2801	Transposase and inactivated derivatives
AVCA_RS05095	COG3415	Transposase
AVCA_RS05105	COG2827	Endonuclease containing a URI domain
AVCA_RS05125	COG0145	ligase activity
AVCA_RS05130	COG4647	ligase activity
AVCA_RS05135	COG0145	ligase activity
AVCA_RS05145	COG0523	cobalamin synthesis protein
AVCA_RS05155	COG3081	Nucleoid-associated protein
AVCA_RS05165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVCA_RS05175	COG0583	DNA-binding transcription factor activity
AVCA_RS05185	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS05200	COG0420	3'-5' exonuclease activity
AVCA_RS05205	COG0419	ATPase involved in DNA repair
AVCA_RS05215	COG1253	flavin adenine dinucleotide binding
AVCA_RS05225	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AVCA_RS05250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AVCA_RS05255	COG0795	lipopolysaccharide-transporting ATPase activity
AVCA_RS05260	COG0795	lipopolysaccharide-transporting ATPase activity
AVCA_RS05270	COG1278	Cold shock
AVCA_RS05285	COG0728	peptidoglycan biosynthetic process
AVCA_RS05290	COG0196	riboflavin kinase activity
AVCA_RS05295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AVCA_RS05300	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AVCA_RS05305	COG1047	Peptidyl-prolyl cis-trans
AVCA_RS05310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AVCA_RS05345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVCA_RS05400	COG1132	(ABC) transporter
AVCA_RS05410	COG1252	NADH dehydrogenase
AVCA_RS05435	COG0237	dephospho-CoA kinase activity
AVCA_RS05440	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AVCA_RS05465	COG3023	N-Acetylmuramoyl-L-alanine amidase
AVCA_RS05475	COG0084	hydrolase, TatD family'
AVCA_RS05495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVCA_RS05495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVCA_RS05500	COG1105	Belongs to the carbohydrate kinase PfkB family
AVCA_RS05505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AVCA_RS05505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AVCA_RS05505	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AVCA_RS05525	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AVCA_RS05530	COG2831	hemolysin activation secretion protein
AVCA_RS05545	COG0019	diaminopimelate decarboxylase activity
AVCA_RS05550	COG4774	siderophore transport
AVCA_RS05555	COG3128	pkhd-type hydroxylase
AVCA_RS05590	COG3128	pkhd-type hydroxylase
AVCA_RS05595	COG4774	siderophore transport
AVCA_RS05610	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AVCA_RS05615	COG1984	allophanate hydrolase subunit 2
AVCA_RS05620	COG4608	Belongs to the ABC transporter superfamily
AVCA_RS05625	COG0444	Belongs to the ABC transporter superfamily
AVCA_RS05630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVCA_RS05635	COG0601	transmembrane transport
AVCA_RS05640	COG0747	negative chemotaxis
AVCA_RS05655	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AVCA_RS05675	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AVCA_RS05680	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AVCA_RS05685	COG0154	amidase activity
AVCA_RS05690	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AVCA_RS05695	COG1077	Cell shape determining protein MreB Mrl
AVCA_RS05700	COG1792	Involved in formation and maintenance of cell shape
AVCA_RS05705	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AVCA_RS05710	COG0424	maF-like protein
AVCA_RS05715	COG1530	ribonuclease E activity
AVCA_RS05725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVCA_RS05735	COG3028	Belongs to the UPF0307 family
AVCA_RS05740	COG0312	modulator of DNA gyrase
AVCA_RS05750	COG1660	Displays ATPase and GTPase activities
AVCA_RS05770	COG1137	ATPase activity
AVCA_RS05775	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AVCA_RS05785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AVCA_RS05795	COG1127	ABC transporter
AVCA_RS05800	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AVCA_RS05805	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AVCA_RS05820	COG5007	Belongs to the BolA IbaG family
AVCA_RS05825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AVCA_RS05830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AVCA_RS05835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AVCA_RS05840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVCA_RS05845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVCA_RS05855	COG0175	sulfate reduction
AVCA_RS05880	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AVCA_RS05885	COG1515	deoxyribonuclease V activity
AVCA_RS05890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AVCA_RS05895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AVCA_RS05900	COG0723	plastoquinol--plastocyanin reductase activity
AVCA_RS05905	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AVCA_RS05910	COG2857	Cytochrome c1
AVCA_RS05915	COG0625	glutathione transferase activity
AVCA_RS05920	COG2969	positive regulation of protein catabolic process
AVCA_RS05925	COG2823	Periplasmic or secreted lipoprotein
AVCA_RS05930	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AVCA_RS05935	COG0792	nuclease activity
AVCA_RS05950	COG2001	Belongs to the MraZ family
AVCA_RS05955	COG0275	rRNA processing
AVCA_RS05970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVCA_RS05975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AVCA_RS05980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AVCA_RS05985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AVCA_RS05990	COG0772	Belongs to the SEDS family
AVCA_RS05995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AVCA_RS06000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AVCA_RS06005	COG1181	Belongs to the D-alanine--D-alanine ligase family
AVCA_RS06025	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AVCA_RS06035	COG0653	protein targeting
AVCA_RS06050	COG0494	nUDIX hydrolase
AVCA_RS06055	COG2096	Adenosyltransferase
AVCA_RS06070	COG1666	GTP binding
AVCA_RS06085	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS06090	COG0748	coenzyme F420 binding
AVCA_RS06095	COG3030	protein affecting phage T7 exclusion by the F plasmid
AVCA_RS06100	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AVCA_RS06140	COG1024	Enoyl-CoA hydratase
AVCA_RS06165	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AVCA_RS06205	COG3086	response to oxidative stress
AVCA_RS06210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVCA_RS06215	COG0481	GTPase activity
AVCA_RS06230	COG0571	ribonuclease III activity
AVCA_RS06235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AVCA_RS06245	COG1381	Involved in DNA repair and RecF pathway recombination
AVCA_RS06250	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AVCA_RS06260	COG0500	methyltransferase
AVCA_RS06265	COG2226	methyltransferase
AVCA_RS06275	COG1414	Transcriptional regulator
AVCA_RS06285	COG1454	alcohol dehydrogenase
AVCA_RS06290	COG2610	gluconate transmembrane transporter activity
AVCA_RS06295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AVCA_RS06315	COG0583	DNA-binding transcription factor activity
AVCA_RS06340	COG3842	ATPase activity
AVCA_RS06350	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AVCA_RS06360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AVCA_RS06365	COG0418	dihydroorotase activity
AVCA_RS06370	COG0137	argininosuccinate synthase activity
AVCA_RS06410	COG0521	Mo-molybdopterin cofactor biosynthetic process
AVCA_RS06415	COG0303	'Molybdopterin
AVCA_RS06430	COG0488	(ABC) transporter
AVCA_RS06435	COG0589	response to stress
AVCA_RS06440	COG2814	Major facilitator Superfamily
AVCA_RS06455	COG1024	Enoyl-CoA hydratase
AVCA_RS06460	COG1012	belongs to the aldehyde dehydrogenase family
AVCA_RS06465	COG3320	Male sterility
AVCA_RS06465	COG1022	Amp-dependent synthetase and ligase
AVCA_RS06475	COG1960	acyl-CoA dehydrogenase activity
AVCA_RS06495	COG0745	RESPONSE REGULATOR receiver
AVCA_RS06500	COG2205	protein histidine kinase activity
AVCA_RS06505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVCA_RS06510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVCA_RS06550	COG1024	Enoyl-CoA hydratase
AVCA_RS06550	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVCA_RS06555	COG0183	Belongs to the thiolase family
AVCA_RS06585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AVCA_RS06605	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AVCA_RS06615	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AVCA_RS06630	COG1805	sodium ion transport
AVCA_RS06645	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AVCA_RS06655	COG1477	protein flavinylation
AVCA_RS06665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVCA_RS06670	COG0584	glycerophosphoryl diester phosphodiesterase
AVCA_RS06680	COG1136	(ABC) transporter
AVCA_RS06685	COG4591	ABC-type transport system involved in lipoprotein release permease component
AVCA_RS06695	COG0658	competence protein
AVCA_RS06695	COG2333	competence protein COMEC
AVCA_RS06700	COG0811	peptide transport
AVCA_RS06705	COG0848	biopolymer transport protein
AVCA_RS06710	COG1663	tetraacyldisaccharide 4'-kinase activity
AVCA_RS06715	COG2835	tetraacyldisaccharide 4'-kinase activity
AVCA_RS06725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AVCA_RS06730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AVCA_RS06735	COG1530	ribonuclease E activity
AVCA_RS06745	COG0546	phosphoglycolate phosphatase activity
AVCA_RS06750	COG0616	signal peptide processing
AVCA_RS06750	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AVCA_RS06755	COG0424	maF-like protein
AVCA_RS06765	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AVCA_RS06770	COG0416	fatty acid biosynthetic process
AVCA_RS06785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVCA_RS06790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVCA_RS06800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AVCA_RS06820	COG0084	hydrolase, TatD family'
AVCA_RS06830	COG3293	Transposase
AVCA_RS06835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVCA_RS06845	COG1355	regulation of microtubule-based process
AVCA_RS06850	COG1960	acyl-CoA dehydrogenase activity
AVCA_RS06855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVCA_RS06860	COG2267	carboxylic ester hydrolase activity
AVCA_RS06865	COG1414	Transcriptional regulator
AVCA_RS06870	COG3971	2-oxopent-4-enoate hydratase activity
AVCA_RS06875	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AVCA_RS06880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVCA_RS06885	COG2814	Major facilitator Superfamily
AVCA_RS06945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AVCA_RS06950	COG1764	response to oxidative stress
AVCA_RS06955	COG1846	Transcriptional regulator
AVCA_RS06965	COG0730	response to heat
AVCA_RS06980	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AVCA_RS06990	COG0500	methyltransferase
AVCA_RS07000	COG0501	Belongs to the peptidase M48B family
AVCA_RS07005	COG0436	Aminotransferase
AVCA_RS07010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVCA_RS07015	COG0386	Belongs to the glutathione peroxidase family
AVCA_RS07020	COG2205	protein histidine kinase activity
AVCA_RS07020	COG3850	Histidine kinase
AVCA_RS07020	COG4999	Histidine kinase
AVCA_RS07020	COG3437	response regulator, receiver
AVCA_RS07050	COG1960	acyl-CoA dehydrogenase activity
AVCA_RS07055	COG1131	(ABC) transporter
AVCA_RS07060	COG0842	Transport permease protein
AVCA_RS07075	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AVCA_RS07075	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AVCA_RS07080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AVCA_RS07085	COG0727	PFAM Uncharacterised protein family (UPF0153)
AVCA_RS07090	COG0778	Nitroreductase
AVCA_RS07095	COG0642	Histidine kinase
AVCA_RS07105	COG0745	RESPONSE REGULATOR receiver
AVCA_RS07110	COG2350	Protein conserved in bacteria
AVCA_RS07115	COG2917	probably involved in intracellular septation
AVCA_RS07120	COG0613	PHP domain protein
AVCA_RS07125	COG0009	L-threonylcarbamoyladenylate synthase
AVCA_RS07130	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AVCA_RS07135	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AVCA_RS07160	COG0800	Aldolase
AVCA_RS07170	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS07175	COG0546	phosphoglycolate phosphatase activity
AVCA_RS07180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVCA_RS07185	COG0402	S-adenosylhomocysteine deaminase activity
AVCA_RS07190	COG0675	Transposase, IS605 OrfB family
AVCA_RS07195	COG3415	Transposase
AVCA_RS07195	COG2801	Transposase and inactivated derivatives
AVCA_RS07200	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AVCA_RS07210	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AVCA_RS07225	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AVCA_RS07230	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AVCA_RS07240	COG0776	regulation of translation
AVCA_RS07250	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AVCA_RS07260	COG1088	dTDP-glucose 4,6-dehydratase activity
AVCA_RS07280	COG1682	transport, permease protein
AVCA_RS07345	COG1450	Type ii and iii secretion system protein
AVCA_RS07390	COG1459	type II secretion system
AVCA_RS07395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AVCA_RS07420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AVCA_RS07430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVCA_RS07440	COG1643	Atp-dependent helicase
AVCA_RS07445	COG2161	toxin-antitoxin pair type II binding
AVCA_RS07480	COG2814	Major facilitator Superfamily
AVCA_RS07490	COG0183	Belongs to the thiolase family
AVCA_RS07495	COG1024	Enoyl-CoA hydratase
AVCA_RS07495	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVCA_RS07500	COG1960	acyl-CoA dehydrogenase activity
AVCA_RS07520	COG0427	acetyl-CoA hydrolase
AVCA_RS07525	COG2801	Transposase and inactivated derivatives
AVCA_RS07550	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS07575	COG2801	Transposase and inactivated derivatives
AVCA_RS07590	COG1063	alcohol dehydrogenase
AVCA_RS07610	COG0166	Belongs to the GPI family
AVCA_RS07620	COG4580	involved in the transport of maltose and maltodextrins
AVCA_RS07635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVCA_RS07640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVCA_RS07645	COG0427	acetyl-CoA hydrolase
AVCA_RS07650	COG0583	DNA-binding transcription factor activity
AVCA_RS07655	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS07665	COG0842	Transport permease protein
AVCA_RS07670	COG1129	ABC transporter
AVCA_RS07670	COG0842	Transport permease protein
AVCA_RS07675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVCA_RS07680	COG0675	Transposase, IS605 OrfB family
AVCA_RS07685	COG0167	dihydroorotate dehydrogenase activity
AVCA_RS07690	COG3321	synthase
AVCA_RS07690	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS07690	COG0604	alcohol dehydrogenase
AVCA_RS07710	COG4221	oxidoreductase activity
AVCA_RS07720	COG2133	pyrroloquinoline quinone binding
AVCA_RS07810	COG0583	DNA-binding transcription factor activity
AVCA_RS07825	COG2851	Citrate transporter
AVCA_RS07860	COG1857	crispr-associated protein
AVCA_RS07880	COG4680	protein conserved in bacteria
AVCA_RS07900	COG0438	transferase activity, transferring glycosyl groups
AVCA_RS07905	COG2814	Major facilitator Superfamily
AVCA_RS07920	COG2197	response regulator
AVCA_RS07925	COG4585	Histidine kinase
AVCA_RS07930	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVCA_RS07930	COG1024	Enoyl-CoA hydratase
AVCA_RS07935	COG0183	Belongs to the thiolase family
AVCA_RS07940	COG0318	PFAM AMP-dependent synthetase and ligase
AVCA_RS07945	COG1960	acyl-CoA dehydrogenase activity
AVCA_RS07965	COG0003	Pfam Anion-transporting ATPase
AVCA_RS07975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AVCA_RS08000	COG3639	organic phosphonate transmembrane transporter activity
AVCA_RS08005	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AVCA_RS08020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVCA_RS08025	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AVCA_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS08040	COG2610	gluconate transmembrane transporter activity
AVCA_RS08045	COG3604	Transcriptional regulator
AVCA_RS08065	COG0166	Belongs to the GPI family
AVCA_RS08070	COG0738	Major facilitator superfamily
AVCA_RS08105	COG2814	Major facilitator Superfamily
AVCA_RS08115	COG0583	DNA-binding transcription factor activity
AVCA_RS08120	COG3642	lipopolysaccharide core region biosynthetic process
AVCA_RS08130	COG3850	Histidine kinase
AVCA_RS08130	COG5002	protein histidine kinase activity
AVCA_RS08145	COG4067	protein conserved in archaea
AVCA_RS08145	COG0189	ligase activity
AVCA_RS08160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVCA_RS08160	COG0574	Belongs to the PEP-utilizing enzyme family
AVCA_RS08170	COG3002	Belongs to the UPF0753 family
AVCA_RS08205	COG1278	Cold shock
AVCA_RS08225	COG1403	HNH endonuclease
AVCA_RS08230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AVCA_RS08235	COG4191	Histidine kinase
AVCA_RS08245	COG0477	Major facilitator Superfamily
AVCA_RS08260	COG3416	Protein conserved in bacteria
AVCA_RS08265	COG2824	Alkylphosphonate utilization operon protein PhnA
AVCA_RS08300	COG0217	transcriptional regulatory protein
AVCA_RS08325	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AVCA_RS08330	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AVCA_RS08345	COG0826	peptidase U32
AVCA_RS08400	COG1902	pentaerythritol trinitrate reductase activity
AVCA_RS08410	COG1309	transcriptional regulator
AVCA_RS08415	COG0604	alcohol dehydrogenase
AVCA_RS08490	COG0642	Histidine kinase
AVCA_RS08500	COG2900	Belongs to the SlyX family
AVCA_RS08505	COG0747	negative chemotaxis
AVCA_RS08510	COG0601	transmembrane transport
AVCA_RS08515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVCA_RS08525	COG3139	Protein of unknown function (DUF1315)
AVCA_RS08535	COG0308	aminopeptidase N
AVCA_RS08540	COG0427	acetyl-CoA hydrolase
AVCA_RS08545	COG3344	reverse transcriptase
AVCA_RS08580	COG0714	Associated with various cellular activities
AVCA_RS08590	COG0392	lysyltransferase activity
AVCA_RS08590	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AVCA_RS08615	COG0167	dihydroorotate dehydrogenase activity
AVCA_RS08620	COG3130	regulation of translation
AVCA_RS08625	COG0116	Belongs to the methyltransferase superfamily
AVCA_RS08625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AVCA_RS08630	COG2027	D-alanyl-D-alanine carboxypeptidase
AVCA_RS08665	COG1525	nuclease
AVCA_RS08705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AVCA_RS08710	COG0513	Belongs to the DEAD box helicase family
AVCA_RS08715	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AVCA_RS08720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AVCA_RS08725	COG5265	(ABC) transporter
AVCA_RS08730	COG0583	DNA-binding transcription factor activity
AVCA_RS08775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AVCA_RS08785	COG4659	FMN binding
AVCA_RS08790	COG4658	electron transport chain
AVCA_RS08800	COG2878	Part of a membrane complex involved in electron transport
AVCA_RS08805	COG4657	Part of a membrane complex involved in electron transport
AVCA_RS08810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVCA_RS08810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVCA_RS08815	COG0489	protein tyrosine kinase activity
AVCA_RS08820	COG0717	Belongs to the dCTP deaminase family
AVCA_RS08865	COG3012	SEC-C Motif Domain Protein
AVCA_RS08885	COG1199	ATP-dependent helicase activity
AVCA_RS08905	COG0259	pyridoxamine-phosphate oxidase activity
AVCA_RS08915	COG3133	Outer membrane lipoprotein
AVCA_RS08920	COG2111	Na H antiporter
AVCA_RS08920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AVCA_RS08925	COG1006	Multisubunit Na H antiporter MnhC subunit
AVCA_RS08930	COG0651	ATP synthesis coupled electron transport
AVCA_RS08935	COG1863	multisubunit Na H antiporter MnhE subunit
AVCA_RS08940	COG2212	antiporter activity
AVCA_RS08945	COG1320	monovalent cation:proton antiporter activity
AVCA_RS08990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AVCA_RS08995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AVCA_RS09010	COG0356	it plays a direct role in the translocation of protons across the membrane
AVCA_RS09020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AVCA_RS09020	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AVCA_RS09025	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AVCA_RS09035	COG3639	organic phosphonate transmembrane transporter activity
AVCA_RS09040	COG3639	organic phosphonate transmembrane transporter activity
AVCA_RS09050	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AVCA_RS09060	COG3622	Belongs to the hyi family
AVCA_RS09065	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AVCA_RS09070	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AVCA_RS09075	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AVCA_RS09090	COG1294	oxidase, subunit
AVCA_RS09105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVCA_RS09135	COG0348	domain, Protein
AVCA_RS09140	COG2010	Cytochrome c
AVCA_RS09155	COG3278	Belongs to the heme-copper respiratory oxidase family
AVCA_RS09175	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AVCA_RS09205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVCA_RS09210	COG0668	transmembrane transport
AVCA_RS09215	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AVCA_RS09225	COG0564	pseudouridine synthase activity
AVCA_RS09230	COG0071	Belongs to the small heat shock protein (HSP20) family
AVCA_RS09245	COG1414	Transcriptional regulator
AVCA_RS09250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVCA_RS09255	COG1053	succinate dehydrogenase
AVCA_RS09265	COG1053	succinate dehydrogenase
AVCA_RS09285	COG1063	alcohol dehydrogenase
AVCA_RS09305	COG1053	succinate dehydrogenase
AVCA_RS09325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVCA_RS09345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AVCA_RS09355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AVCA_RS09360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AVCA_RS09365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AVCA_RS09370	COG0072	phenylalanine-tRNA ligase activity
AVCA_RS09375	COG0776	regulation of translation
AVCA_RS09415	COG2801	Transposase and inactivated derivatives
AVCA_RS09425	COG2853	Lipoprotein
AVCA_RS09430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AVCA_RS09435	COG0142	geranyltranstransferase activity
AVCA_RS09440	COG1722	exodeoxyribonuclease VII activity
AVCA_RS09450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AVCA_RS09455	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AVCA_RS09495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVCA_RS09510	COG1657	PFAM Prenyltransferase squalene oxidase
AVCA_RS09530	COG0583	DNA-binding transcription factor activity
AVCA_RS09540	COG1902	pentaerythritol trinitrate reductase activity
AVCA_RS09545	COG2814	Major facilitator Superfamily
AVCA_RS09555	COG4396	Host-nuclease inhibitor protein Gam
AVCA_RS09570	COG0145	ligase activity
AVCA_RS09575	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AVCA_RS09580	COG4647	ligase activity
AVCA_RS09585	COG3284	Transcriptional regulator
AVCA_RS09600	COG1045	serine acetyltransferase
AVCA_RS09605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVCA_RS09610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVCA_RS09620	COG2801	Transposase and inactivated derivatives
AVCA_RS09620	COG3415	Transposase
AVCA_RS09630	COG1024	Enoyl-CoA hydratase
AVCA_RS09645	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AVCA_RS09650	COG4266	Belongs to the allantoicase family
AVCA_RS09680	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS09685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVCA_RS09690	COG3433	isochorismatase activity
AVCA_RS09690	COG1535	isochorismatase
AVCA_RS09695	COG1021	2,3-dihydroxybenzoate-AMP ligase
AVCA_RS09700	COG1169	isochorismate synthase
AVCA_RS09715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AVCA_RS09740	COG3842	ATPase activity
AVCA_RS09750	COG1053	succinate dehydrogenase
AVCA_RS09760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA_RS09775	COG0583	DNA-binding transcription factor activity
AVCA_RS09785	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AVCA_RS09790	COG0277	FAD linked oxidase domain protein
AVCA_RS09795	COG0436	Aminotransferase
AVCA_RS09800	COG0765	amino acid transport
AVCA_RS09805	COG0765	amino acid transport
AVCA_RS09810	COG1126	abc transporter atp-binding protein
AVCA_RS09820	COG0625	glutathione transferase activity
AVCA_RS09840	COG3712	iron ion homeostasis
AVCA_RS09845	COG1595	DNA-templated transcription, initiation
AVCA_RS09855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVCA_RS09860	COG0235	Class ii aldolase
AVCA_RS09865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVCA_RS09870	COG1116	anion transmembrane transporter activity
AVCA_RS09875	COG4206	TonB-dependent receptor
AVCA_RS09885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA_RS09890	COG0583	DNA-binding transcription factor activity
AVCA_RS09910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA_RS09915	COG0667	Aldo Keto reductase
AVCA_RS09920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA_RS09940	COG4771	TonB-dependent receptor
AVCA_RS09945	COG1609	Transcriptional regulator
AVCA_RS09950	COG5642	Protein of unknown function (DUF2384)
AVCA_RS09955	COG5654	RES domain protein
AVCA_RS09975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA_RS09985	COG2175	clavaminate synthase activity
AVCA_RS09995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA_RS10000	COG1902	pentaerythritol trinitrate reductase activity
AVCA_RS10015	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AVCA_RS10025	COG0596	Alpha beta hydrolase
AVCA_RS10030	COG2175	clavaminate synthase activity
AVCA_RS10050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVCA_RS10060	COG1063	alcohol dehydrogenase
AVCA_RS10075	COG2376	Dihydroxyacetone kinase
AVCA_RS10080	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS10085	COG1879	ABC-type sugar transport system periplasmic component
AVCA_RS10090	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVCA_RS10095	COG1129	ABC transporter
AVCA_RS10100	COG0698	ribose 5-phosphate isomerase
AVCA_RS10105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVCA_RS10115	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AVCA_RS10135	COG0148	phosphopyruvate hydratase activity
AVCA_RS10140	COG4566	intracellular signal transduction
AVCA_RS10150	COG0318	PFAM AMP-dependent synthetase and ligase
AVCA_RS10155	COG0402	S-adenosylhomocysteine deaminase activity
AVCA_RS10165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVCA_RS10175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AVCA_RS10180	COG2801	Transposase and inactivated derivatives
AVCA_RS10180	COG3415	Transposase
AVCA_RS10200	COG0667	Aldo Keto reductase
AVCA_RS10205	COG0625	glutathione transferase activity
AVCA_RS10210	COG2175	clavaminate synthase activity
AVCA_RS10215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA_RS10245	COG3265	gluconokinase activity
AVCA_RS10260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVCA_RS10265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVCA_RS10270	COG1116	anion transmembrane transporter activity
AVCA_RS10270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA_RS10295	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AVCA_RS10300	COG0625	glutathione transferase activity
AVCA_RS10305	COG4774	siderophore transport
AVCA_RS10310	COG3712	iron ion homeostasis
AVCA_RS10315	COG1595	DNA-templated transcription, initiation
AVCA_RS10345	COG2217	Heavy metal translocating P-type atpase
AVCA_RS10370	COG0783	Belongs to the Dps family
AVCA_RS10405	COG3204	pilus organization
AVCA_RS10425	COG3409	Peptidoglycan-binding domain 1 protein
AVCA_RS10425	COG3267	Type II secretory pathway component ExeA
AVCA_RS10470	COG0084	hydrolase, TatD family'
AVCA_RS10475	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AVCA_RS10490	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AVCA_RS10495	COG4181	ATPase activity
AVCA_RS10545	COG0189	ligase activity
AVCA_RS10560	COG1802	Transcriptional regulator
AVCA_RS10585	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AVCA_RS10595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AVCA_RS10605	COG0668	transmembrane transport
AVCA_RS10625	COG0243	molybdopterin cofactor binding
AVCA_RS10630	COG2146	nitrite reductase [NAD(P)H] activity
AVCA_RS10635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AVCA_RS10640	COG2815	serine threonine protein kinase
AVCA_RS10640	COG0515	serine threonine protein kinase
AVCA_RS10645	COG2223	nitrite transmembrane transporter activity
AVCA_RS10665	COG0436	Aminotransferase
AVCA_RS10680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA_RS10680	COG1116	anion transmembrane transporter activity
AVCA_RS10700	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVCA_RS10710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVCA_RS10715	COG0215	cysteine-tRNA ligase activity
AVCA_RS10720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AVCA_RS10740	COG0544	peptidyl-prolyl cis-trans isomerase activity
AVCA_RS10750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AVCA_RS10755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AVCA_RS10770	COG3243	poly(R)-hydroxyalkanoic acid synthase
AVCA_RS10780	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS10795	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AVCA_RS10800	COG0302	gtp cyclohydrolase
AVCA_RS10815	COG1335	isochorismatase
AVCA_RS10830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AVCA_RS10840	COG0235	Class ii aldolase
AVCA_RS10850	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AVCA_RS10860	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AVCA_RS10880	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AVCA_RS10920	COG3293	Transposase
AVCA_RS10945	COG1815	bacterial-type flagellum-dependent cell motility
AVCA_RS10950	COG1558	bacterial-type flagellum-dependent cell motility
AVCA_RS10955	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AVCA_RS10965	COG4787	bacterial-type flagellum-dependent cell motility
AVCA_RS10975	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AVCA_RS10980	COG1706	bacterial-type flagellum-dependent cell motility
AVCA_RS10985	COG3951	Flagellar rod assembly protein muramidase FlgJ
AVCA_RS10985	COG1705	Flagellar rod assembly protein muramidase FlgJ
AVCA_RS11025	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AVCA_RS11060	COG1766	The M ring may be actively involved in energy transduction
AVCA_RS11065	COG1677	Flagellar hook-basal body complex protein FliE
AVCA_RS11090	COG2257	FlhB HrpN YscU SpaS Family
AVCA_RS11110	COG1360	Flagellar Motor Protein
AVCA_RS11115	COG2198	Histidine kinase
AVCA_RS11115	COG0643	Histidine kinase
AVCA_RS11120	COG0835	chemotaxis
AVCA_RS11125	COG0840	transmembrane signaling receptor activity
AVCA_RS11130	COG0840	transmembrane signaling receptor activity
AVCA_RS11135	COG0840	transmembrane signaling receptor activity
AVCA_RS11150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVCA_RS11160	COG0747	negative chemotaxis
AVCA_RS11190	COG2205	protein histidine kinase activity
AVCA_RS11195	COG0745	RESPONSE REGULATOR receiver
AVCA_RS11200	COG3158	transport of potassium into the cell
AVCA_RS11225	COG3344	reverse transcriptase
AVCA_RS11260	COG2814	Major facilitator Superfamily
AVCA_RS11280	COG3344	reverse transcriptase
AVCA_RS11295	COG0604	alcohol dehydrogenase
AVCA_RS11305	COG0392	lysyltransferase activity
AVCA_RS11310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AVCA_RS11315	COG3568	Endonuclease Exonuclease Phosphatase
AVCA_RS11350	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AVCA_RS11355	COG0297	glycogen (starch) synthase activity
AVCA_RS11360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVCA_RS11365	COG1960	acyl-CoA dehydrogenase activity
AVCA_RS11370	COG0477	Major facilitator Superfamily
AVCA_RS11375	COG0583	DNA-binding transcription factor activity
AVCA_RS11380	COG0659	secondary active sulfate transmembrane transporter activity
AVCA_RS11420	COG0322	excinuclease ABC activity
AVCA_RS11440	COG1309	transcriptional regulator
AVCA_RS11495	COG0784	Response regulator, receiver
AVCA_RS11495	COG2205	protein histidine kinase activity
AVCA_RS11495	COG2198	Histidine kinase
AVCA_RS11505	COG2200	EAL domain
AVCA_RS11505	COG2199	diguanylate cyclase activity
AVCA_RS11505	COG2202	Pas domain
AVCA_RS11525	COG1960	acyl-CoA dehydrogenase activity
AVCA_RS11530	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVCA_RS11535	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVCA_RS11545	COG0318	PFAM AMP-dependent synthetase and ligase
AVCA_RS11550	COG4191	Histidine kinase
AVCA_RS11585	COG4566	intracellular signal transduction
AVCA_RS11590	COG1309	transcriptional regulator
AVCA_RS11595	COG1752	Esterase of the alpha-beta hydrolase superfamily
AVCA_RS11730	COG0069	glutamate synthase activity
AVCA_RS11765	COG0543	2 iron, 2 sulfur cluster binding
AVCA_RS11765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVCA_RS11770	COG0071	Belongs to the small heat shock protein (HSP20) family
AVCA_RS11775	COG0459	protein refolding
AVCA_RS11780	COG0589	response to stress
AVCA_RS11795	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AVCA_RS11800	COG2010	Cytochrome c
AVCA_RS11800	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVCA_RS11810	COG0667	Aldo Keto reductase
AVCA_RS11815	COG0583	DNA-binding transcription factor activity
AVCA_RS11820	COG1368	sulfuric ester hydrolase activity
AVCA_RS11825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AVCA_RS11830	COG1742	UPF0060 membrane protein
AVCA_RS11835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AVCA_RS11840	COG0640	Transcriptional regulator
AVCA_RS11860	COG2271	Major facilitator Superfamily
AVCA_RS11865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVCA_RS11870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVCA_RS11885	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVCA_RS11885	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVCA_RS11890	COG1760	l-serine dehydratase
AVCA_RS11895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AVCA_RS11945	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AVCA_RS11950	COG1609	Transcriptional regulator
AVCA_RS11955	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS11985	COG5642	Protein of unknown function (DUF2384)
AVCA_RS11995	COG2986	histidine ammonia-lyase
AVCA_RS12000	COG0402	S-adenosylhomocysteine deaminase activity
AVCA_RS12050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVCA_RS12055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVCA_RS12060	COG1120	ATPase activity
AVCA_RS12075	COG2267	carboxylic ester hydrolase activity
AVCA_RS12180	COG0515	serine threonine protein kinase
AVCA_RS12240	COG0477	Major facilitator Superfamily
AVCA_RS12245	COG0579	oxidoreductase
AVCA_RS12255	COG0579	oxidoreductase
AVCA_RS12260	COG2186	Transcriptional regulator
AVCA_RS12265	COG1609	Transcriptional regulator
AVCA_RS12275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVCA_RS12295	COG4580	involved in the transport of maltose and maltodextrins
AVCA_RS12330	COG0483	inositol monophosphate 1-phosphatase activity
AVCA_RS12335	COG0612	Peptidase, M16
AVCA_RS12355	COG1611	Belongs to the LOG family
AVCA_RS12365	COG2814	Major facilitator Superfamily
AVCA_RS12390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AVCA_RS12395	COG4580	involved in the transport of maltose and maltodextrins
AVCA_RS12405	COG0148	phosphopyruvate hydratase activity
AVCA_RS12415	COG0800	Aldolase
AVCA_RS12425	COG1737	Transcriptional regulator
AVCA_RS12435	COG1609	Transcriptional regulator
AVCA_RS12440	COG3265	gluconokinase activity
AVCA_RS12445	COG1070	Carbohydrate kinase
AVCA_RS12450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AVCA_RS12460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVCA_RS12475	COG0395	ABC-type sugar transport system, permease component
AVCA_RS12480	COG1175	transmembrane transport
AVCA_RS12490	COG1917	Cupin 2, conserved barrel domain protein
AVCA_RS12490	COG4977	sequence-specific DNA binding
AVCA_RS12495	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AVCA_RS12500	COG2706	6-phosphogluconolactonase activity
AVCA_RS12520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AVCA_RS12540	COG3344	reverse transcriptase
AVCA_RS12545	COG0616	signal peptide processing
AVCA_RS12560	COG2816	NAD+ diphosphatase activity
AVCA_RS12625	COG1215	transferase activity, transferring glycosyl groups
AVCA_RS12655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AVCA_RS12680	COG1334	flagellar protein FlaG
AVCA_RS12685	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AVCA_RS12690	COG1191	sigma factor activity
AVCA_RS12710	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AVCA_RS12715	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AVCA_RS12720	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AVCA_RS12725	COG0745	RESPONSE REGULATOR receiver
AVCA_RS12730	COG0840	transmembrane signaling receptor activity
AVCA_RS12735	COG0840	transmembrane signaling receptor activity
AVCA_RS12740	COG2201	protein-glutamate methylesterase activity
AVCA_RS12745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AVCA_RS12750	COG0366	Alpha amylase catalytic
AVCA_RS12760	COG1944	ATP diphosphatase activity
AVCA_RS12765	COG2081	HI0933 family
AVCA_RS12825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AVCA_RS12830	COG1648	precorrin-2 dehydrogenase activity
AVCA_RS12830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AVCA_RS12835	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AVCA_RS12840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AVCA_RS12845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AVCA_RS12850	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AVCA_RS12860	COG0492	ferredoxin-NADP+ reductase activity
AVCA_RS12865	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AVCA_RS12870	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AVCA_RS12875	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AVCA_RS12880	COG0542	response to heat
AVCA_RS12885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AVCA_RS12890	COG1278	Cold shock
AVCA_RS12915	COG0482	sulfurtransferase activity
AVCA_RS12920	COG2915	High frequency lysogenization protein hflD homolog
AVCA_RS12930	COG2850	peptidyl-arginine hydroxylation
AVCA_RS12935	COG2153	protein acetylation
AVCA_RS12955	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVCA_RS12960	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVCA_RS12965	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVCA_RS12965	COG0649	NAD binding
AVCA_RS12985	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AVCA_RS12990	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVCA_RS13000	COG0713	ATP synthesis coupled electron transport
AVCA_RS13015	COG1007	ATP synthesis coupled electron transport
AVCA_RS13030	COG3212	peptidase
AVCA_RS13035	COG0720	synthase
AVCA_RS13040	COG0741	lytic transglycosylase activity
AVCA_RS13050	COG1459	type II secretion system
AVCA_RS13065	COG2135	peptidase activity
AVCA_RS13075	COG0488	(ABC) transporter
AVCA_RS13080	COG1968	undecaprenyl-diphosphatase activity
AVCA_RS13090	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AVCA_RS13090	COG0316	Belongs to the HesB IscA family
AVCA_RS13100	COG1538	Outer membrane efflux protein
AVCA_RS13125	COG1115	amino acid carrier protein
AVCA_RS13130	COG2911	Protein conserved in bacteria
AVCA_RS13135	COG0729	surface antigen
AVCA_RS13165	COG0300	oxidoreductase activity
AVCA_RS13180	COG0300	oxidoreductase activity
AVCA_RS13190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVCA_RS13205	COG4191	Histidine kinase
AVCA_RS13215	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AVCA_RS13220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AVCA_RS13275	COG0745	RESPONSE REGULATOR receiver
AVCA_RS13290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AVCA_RS13300	COG1469	GTP cyclohydrolase I activity
AVCA_RS13325	COG1653	transport
AVCA_RS13330	COG5002	protein histidine kinase activity
AVCA_RS13330	COG0784	Response regulator, receiver
AVCA_RS13330	COG2205	protein histidine kinase activity
AVCA_RS13340	COG0322	excinuclease ABC activity
AVCA_RS13345	COG4702	Belongs to the UPF0303 family
AVCA_RS13360	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AVCA_RS13385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVCA_RS13390	COG1116	anion transmembrane transporter activity
AVCA_RS13395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA_RS13405	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AVCA_RS13425	COG0577	efflux transmembrane transporter activity
AVCA_RS13465	COG0328	RNA-DNA hybrid ribonuclease activity
AVCA_RS13480	COG0741	lytic transglycosylase activity
AVCA_RS13480	COG1388	LysM domain
AVCA_RS13490	COG4166	transmembrane transport
AVCA_RS13495	COG4174	ABC transporter (Permease)
AVCA_RS13500	COG4239	(ABC) transporter, permease
AVCA_RS13505	COG4172	Belongs to the ABC transporter superfamily
AVCA_RS13515	COG2233	PERMEase
AVCA_RS13535	COG0045	succinate-CoA ligase (ADP-forming) activity
AVCA_RS13560	COG1053	succinate dehydrogenase
AVCA_RS13565	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AVCA_RS13570	COG2009	succinate dehydrogenase
AVCA_RS13595	COG3123	guanosine phosphorylase activity
AVCA_RS13605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVCA_RS13620	COG0489	protein tyrosine kinase activity
AVCA_RS13620	COG3206	protein involved in exopolysaccharide biosynthesis
AVCA_RS13625	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AVCA_RS13630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVCA_RS13635	COG1132	(ABC) transporter
AVCA_RS13640	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AVCA_RS13655	COG0463	Glycosyl transferase, family 2
AVCA_RS13665	COG0438	transferase activity, transferring glycosyl groups
AVCA_RS13670	COG0438	transferase activity, transferring glycosyl groups
AVCA_RS13675	COG0438	transferase activity, transferring glycosyl groups
AVCA_RS13690	COG0438	transferase activity, transferring glycosyl groups
AVCA_RS13695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AVCA_RS13705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AVCA_RS13720	COG1216	Glycosyl transferase, family 2
AVCA_RS13725	COG1216	Glycosyl transferase, family 2
AVCA_RS13725	COG1442	glycosyl transferase family 8
AVCA_RS13735	COG0318	PFAM AMP-dependent synthetase and ligase
AVCA_RS13740	COG2030	dehydratase
AVCA_RS13745	COG0402	S-adenosylhomocysteine deaminase activity
AVCA_RS13760	COG0673	inositol 2-dehydrogenase activity
AVCA_RS13780	COG1053	succinate dehydrogenase
AVCA_RS13790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AVCA_RS13795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AVCA_RS13800	COG3115	cell septum assembly
AVCA_RS13805	COG1196	nuclear chromosome segregation
AVCA_RS13810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AVCA_RS13845	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AVCA_RS13900	COG1116	anion transmembrane transporter activity
AVCA_RS13905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVCA_RS13910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA_RS13915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA_RS13920	COG0431	NADPH-dependent FMN reductase
AVCA_RS13925	COG0450	alkyl hydroperoxide reductase
AVCA_RS13930	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AVCA_RS13945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVCA_RS13950	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AVCA_RS13980	COG3550	peptidyl-serine autophosphorylation
AVCA_RS14000	COG0798	PFAM Bile acid sodium symporter
AVCA_RS14015	COG2871	sodium ion transport
AVCA_RS14085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVCA_RS14095	COG4221	oxidoreductase activity
AVCA_RS14100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVCA_RS14105	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AVCA_RS14115	COG2175	clavaminate synthase activity
AVCA_RS14125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVCA_RS14145	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS14185	COG1960	acyl-CoA dehydrogenase activity
AVCA_RS14200	COG1116	anion transmembrane transporter activity
AVCA_RS14205	COG2205	protein histidine kinase activity
AVCA_RS14210	COG0745	RESPONSE REGULATOR receiver
AVCA_RS14225	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AVCA_RS14235	COG1301	dicarboxylic acid transport
AVCA_RS14240	COG0583	DNA-binding transcription factor activity
AVCA_RS14255	COG3384	dioxygenase
AVCA_RS14260	COG0583	DNA-binding transcription factor activity
AVCA_RS14265	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AVCA_RS14270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AVCA_RS14275	COG2828	Protein conserved in bacteria
AVCA_RS14290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA_RS14310	COG0235	Class ii aldolase
AVCA_RS14315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA_RS14325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA_RS14335	COG0673	inositol 2-dehydrogenase activity
AVCA_RS14345	COG1335	isochorismatase
AVCA_RS14375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AVCA_RS14380	COG2011	ABC-type metal ion transport system permease component
AVCA_RS14395	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AVCA_RS14400	COG1518	maintenance of DNA repeat elements
AVCA_RS14440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA_RS14460	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AVCA_RS14465	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AVCA_RS14470	COG4208	sulfate ABC transporter
AVCA_RS14480	COG3781	membrane
AVCA_RS14520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AVCA_RS14530	COG4118	positive regulation of growth
AVCA_RS14545	COG4680	protein conserved in bacteria
AVCA_RS14575	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
AVCA_RS14615	COG3385	transposase activity
AVCA_RS14645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVCA_RS14650	COG1960	acyl-CoA dehydrogenase activity
AVCA_RS14655	COG3039	Transposase
AVCA_RS14680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA_RS14700	COG1073	alpha beta
AVCA_RS14715	COG2814	Major facilitator Superfamily
AVCA_RS14720	COG1064	alcohol dehydrogenase
AVCA_RS14745	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS14750	COG2207	Transcriptional regulator
AVCA_RS14765	COG0667	Aldo Keto reductase
AVCA_RS14775	COG0300	oxidoreductase activity
AVCA_RS14780	COG0667	Aldo Keto reductase
AVCA_RS14790	COG0667	Aldo Keto reductase
AVCA_RS14830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AVCA_RS14835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AVCA_RS14845	COG0745	RESPONSE REGULATOR receiver
AVCA_RS14850	COG2853	Lipoprotein
AVCA_RS14885	COG0514	ATP-dependent DNA helicase (RecQ)
AVCA_RS14895	COG2832	Protein of unknown function (DUF454)
AVCA_RS14905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AVCA_RS14920	COG0121	glutamine amidotransferase
AVCA_RS14935	COG1295	ribonuclease BN
AVCA_RS14945	COG2983	Belongs to the UPF0260 family
AVCA_RS14955	COG3100	YcgL domain-containing protein
AVCA_RS14985	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AVCA_RS14990	COG0406	alpha-ribazole phosphatase activity
AVCA_RS14995	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AVCA_RS15005	COG1492	cobalamin metabolic process
AVCA_RS15015	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AVCA_RS15020	COG0778	Nitroreductase
AVCA_RS15025	COG1797	cobyrinic acid a,c-diamide synthase activity
AVCA_RS15040	COG4206	TonB-dependent receptor
AVCA_RS15045	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AVCA_RS15050	COG0505	Belongs to the CarA family
AVCA_RS15055	COG0791	NLP P60 protein
AVCA_RS15060	COG0791	NLP P60 protein
AVCA_RS15075	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AVCA_RS15080	COG0037	tRNA processing
AVCA_RS15090	COG3091	SprT-like family
AVCA_RS15110	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AVCA_RS15110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AVCA_RS15115	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AVCA_RS15125	COG3293	Transposase
AVCA_RS15140	COG1943	Transposase
AVCA_RS15145	COG2226	methyltransferase
AVCA_RS15190	COG0861	Integral membrane protein TerC family
AVCA_RS15225	COG2801	Transposase and inactivated derivatives
AVCA_RS15225	COG3415	Transposase
AVCA_RS15250	COG4580	involved in the transport of maltose and maltodextrins
AVCA_RS15270	COG1609	Transcriptional regulator
AVCA_RS15280	COG2814	Major facilitator Superfamily
AVCA_RS15280	COG0477	Major facilitator Superfamily
AVCA_RS15285	COG1082	Xylose isomerase domain protein TIM barrel
AVCA_RS15310	COG0583	DNA-binding transcription factor activity
AVCA_RS15320	COG2031	fatty acid transporter
AVCA_RS15325	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVCA_RS15335	COG1785	Belongs to the alkaline phosphatase family
AVCA_RS15345	COG0604	alcohol dehydrogenase
AVCA_RS15370	COG2084	Dehydrogenase
AVCA_RS15385	COG1609	Transcriptional regulator
AVCA_RS15425	COG0705	Rhomboid family
AVCA_RS15430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AVCA_RS15435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AVCA_RS15485	COG1286	toxin biosynthetic process
AVCA_RS15495	COG0285	dihydrofolate synthase activity
AVCA_RS15500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AVCA_RS15505	COG0135	phosphoribosylanthranilate isomerase activity
AVCA_RS15530	COG0473	3-isopropylmalate dehydrogenase activity
AVCA_RS15540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AVCA_RS15560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AVCA_RS15570	COG0800	Aldolase
AVCA_RS15580	COG0745	RESPONSE REGULATOR receiver
AVCA_RS15615	COG2239	Acts as a magnesium transporter
AVCA_RS15640	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AVCA_RS15650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AVCA_RS15670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVCA_RS15680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVCA_RS15690	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AVCA_RS15695	COG2301	Belongs to the HpcH HpaI aldolase family
AVCA_RS15730	COG2154	pterin-4-alpha-carbinolamine dehydratase
AVCA_RS15810	COG0271	Belongs to the BolA IbaG family
AVCA_RS15820	COG0114	fumarate hydratase activity
AVCA_RS15845	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AVCA_RS15845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVCA_RS15850	COG1846	Transcriptional regulator
AVCA_RS15855	COG0367	asparagine synthase
AVCA_RS15860	COG0189	ligase activity
AVCA_RS15860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVCA_RS15865	COG1363	Peptidase, m42
AVCA_RS15875	COG3089	Belongs to the UPF0270 family
AVCA_RS15885	COG1253	flavin adenine dinucleotide binding
AVCA_RS15890	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVCA_RS15895	COG3162	membrane
AVCA_RS15920	COG2853	Lipoprotein
AVCA_RS15925	COG1560	Kdo2-lipid A biosynthetic process
AVCA_RS15930	COG0850	regulation of cytokinetic process
AVCA_RS15935	COG2894	cell division
AVCA_RS15940	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AVCA_RS15945	COG0564	pseudouridine synthase activity
AVCA_RS15950	COG1362	aminopeptidase activity
AVCA_RS15955	COG0604	alcohol dehydrogenase
AVCA_RS15955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVCA_RS15955	COG3321	synthase
AVCA_RS15955	COG4221	oxidoreductase activity
AVCA_RS15975	COG3339	Conserved Protein
AVCA_RS15980	COG0545	Peptidyl-prolyl cis-trans isomerase
AVCA_RS16000	COG2205	protein histidine kinase activity
AVCA_RS16005	COG3174	membrane
AVCA_RS16045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AVCA_RS16050	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AVCA_RS16055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVCA_RS16065	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AVCA_RS16070	COG0425	Belongs to the sulfur carrier protein TusA family
AVCA_RS16075	COG4783	chaperone-mediated protein folding
AVCA_RS16080	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AVCA_RS16090	COG0471	metal ion transport
AVCA_RS16105	COG1064	alcohol dehydrogenase
AVCA_RS16130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AVCA_RS16190	COG3846	protein secretion by the type IV secretion system
AVCA_RS16205	COG3451	type IV secretory pathway VirB4
AVCA_RS16215	COG3838	Conjugal transfer protein Trbc
AVCA_RS16220	COG4962	Type ii secretion system protein e
AVCA_RS16240	COG0583	DNA-binding transcription factor activity
AVCA_RS16265	COG1309	transcriptional regulator
AVCA_RS16270	COG2249	NAD(P)H dehydrogenase (quinone) activity
AVCA_RS16285	COG0583	DNA-binding transcription factor activity
AVCA_RS16290	COG2814	Major facilitator Superfamily
AVCA_RS16305	COG0583	DNA-binding transcription factor activity
AVCA_RS16310	COG2814	Major facilitator Superfamily
AVCA_RS16325	COG4959	Type IV secretory pathway protease TraF
AVCA_RS16370	COG2003	Belongs to the UPF0758 family
AVCA_RS16405	COG3657	addiction module killer protein
AVCA_RS16425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVCA_RS16435	COG3293	Transposase
AVCA_RS16515	COG2963	transposase activity
AVCA_RS16600	COG2801	Transposase and inactivated derivatives
AVCA_RS16645	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AVCA_RS16655	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AVCA_RS16660	COG0602	queuosine metabolic process
AVCA_RS16665	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AVCA_RS16695	COG0824	Thioesterase
AVCA_RS16700	COG2255	four-way junction helicase activity
AVCA_RS16710	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AVCA_RS16720	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AVCA_RS16730	COG0442	prolyl-tRNA aminoacylation
AVCA_RS16750	COG1295	ribonuclease BN
AVCA_RS16770	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AVCA_RS16775	COG0628	permease
AVCA_RS16790	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AVCA_RS16795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AVCA_RS16805	COG3077	Addiction module antitoxin, RelB DinJ family
AVCA_RS16815	COG3122	Protein conserved in bacteria
AVCA_RS16820	COG3956	TIGRFAM MazG family protein
AVCA_RS16840	COG2819	hydrolase of the alpha beta superfamily
AVCA_RS16845	COG0500	methyltransferase
AVCA_RS16870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AVCA_RS16875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AVCA_RS16885	COG0784	Response regulator, receiver
AVCA_RS16885	COG5002	protein histidine kinase activity
AVCA_RS16885	COG2205	protein histidine kinase activity
AVCA_RS16890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AVCA_RS16940	COG3561	AntA/AntB antirepressor
AVCA_RS17120	COG4695	Portal protein
AVCA_RS17130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AVCA_RS17145	COG2308	Evidence 4 Homologs of previously reported genes of
AVCA_RS17150	COG0693	protein deglycase activity
AVCA_RS17155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AVCA_RS17185	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AVCA_RS17195	COG1902	pentaerythritol trinitrate reductase activity
AVCA_RS17210	COG5001	Diguanylate cyclase
AVCA_RS17210	COG3300	MHYT domain
AVCA_RS17235	COG2831	hemolysin activation secretion protein
AVCA_RS17255	COG0583	DNA-binding transcription factor activity
AVCA_RS17260	COG3321	synthase
AVCA_RS17260	COG0604	alcohol dehydrogenase
AVCA_RS17260	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS17275	COG2814	Major facilitator Superfamily
AVCA_RS17290	COG0667	Aldo Keto reductase
AVCA_RS17295	COG0667	Aldo Keto reductase
AVCA_RS17310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AVCA_RS17315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVCA_RS17320	COG1309	transcriptional regulator
AVCA_RS17325	COG1082	Xylose isomerase domain protein TIM barrel
AVCA_RS17325	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AVCA_RS17340	COG0656	L-ascorbic acid biosynthetic process
AVCA_RS17350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVCA_RS17355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVCA_RS17370	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AVCA_RS17375	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AVCA_RS17380	COG1414	Transcriptional regulator
AVCA_RS17385	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AVCA_RS17390	COG3485	protocatechuate 3,4-dioxygenase
AVCA_RS17395	COG3485	protocatechuate 3,4-dioxygenase
AVCA_RS17400	COG0583	DNA-binding transcription factor activity
AVCA_RS17405	COG0788	formyltetrahydrofolate deformylase activity
AVCA_RS17415	COG2925	Exonuclease
AVCA_RS17440	COG0714	Associated with various cellular activities
AVCA_RS17455	COG0589	response to stress
AVCA_RS17465	COG3706	GGDEF domain
AVCA_RS17470	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AVCA_RS17470	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AVCA_RS17490	COG0583	DNA-binding transcription factor activity
AVCA_RS17500	COG3148	PFAM DTW domain containing protein
AVCA_RS17510	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AVCA_RS17515	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AVCA_RS17525	COG2137	regulation of response to DNA damage stimulus
AVCA_RS17530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AVCA_RS17535	COG1546	Belongs to the CinA family
AVCA_RS17570	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AVCA_RS17580	COG0840	transmembrane signaling receptor activity
AVCA_RS17585	COG0840	transmembrane signaling receptor activity
AVCA_RS17600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AVCA_RS17605	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AVCA_RS17610	COG0585	pseudouridine synthase activity
AVCA_RS17615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AVCA_RS17620	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AVCA_RS17625	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AVCA_RS17630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AVCA_RS17645	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AVCA_RS17650	COG0504	CTP synthase activity
AVCA_RS17660	COG0825	malonyl-CoA metabolic process
AVCA_RS17670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AVCA_RS17675	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVCA_RS17680	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVCA_RS17685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AVCA_RS17710	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AVCA_RS17720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AVCA_RS17725	COG0233	cytoplasmic translational termination
AVCA_RS17730	COG0528	UMP kinase activity
AVCA_RS17735	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AVCA_RS17740	COG0052	Belongs to the universal ribosomal protein uS2 family
AVCA_RS17745	COG0024	Methionine aminopeptidase
AVCA_RS17750	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AVCA_RS17755	COG0436	Aminotransferase
AVCA_RS17760	COG0025	NhaP-type Na H and K H
AVCA_RS17785	COG1393	Belongs to the ArsC family
AVCA_RS17790	COG2171	N-acyltransferase activity
AVCA_RS17810	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AVCA_RS17825	COG2226	methyltransferase
AVCA_RS17850	COG1131	(ABC) transporter
AVCA_RS17860	COG0742	ribosomal rna small subunit methyltransferase
AVCA_RS17870	COG1801	Protein of unknown function DUF72
AVCA_RS17875	COG1214	PFAM Peptidase M22, glycoprotease
AVCA_RS17880	COG0563	adenylate kinase activity
AVCA_RS17885	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AVCA_RS17905	COG1073	alpha beta
AVCA_RS17930	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AVCA_RS17935	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AVCA_RS17945	COG1902	pentaerythritol trinitrate reductase activity
AVCA_RS17990	COG1607	acyl-coa hydrolase
AVCA_RS17995	COG0335	large ribosomal subunit rRNA binding
AVCA_RS18000	COG0336	Belongs to the RNA methyltransferase TrmD family
AVCA_RS18005	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AVCA_RS18010	COG0228	four-way junction DNA binding
AVCA_RS18015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AVCA_RS18025	COG4536	flavin adenine dinucleotide binding
AVCA_RS18030	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AVCA_RS18035	COG0494	nUDIX hydrolase
AVCA_RS18045	COG1388	LysM domain
AVCA_RS18045	COG1376	ErfK ybiS ycfS ynhG family protein
AVCA_RS18060	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AVCA_RS18070	COG2132	Multicopper oxidase
AVCA_RS18095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVCA_RS18105	COG1570	exodeoxyribonuclease VII activity
AVCA_RS18115	COG0739	heme binding
AVCA_RS18165	COG0583	DNA-binding transcription factor activity
AVCA_RS18170	COG0402	S-adenosylhomocysteine deaminase activity
AVCA_RS18190	COG0477	Major facilitator Superfamily
AVCA_RS18200	COG2909	trisaccharide binding
AVCA_RS18205	COG0371	Dehydrogenase
AVCA_RS18215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVCA_RS18225	COG4993	Dehydrogenase
AVCA_RS18235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA_RS18250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVCA_RS18255	COG2356	endonuclease I
AVCA_RS18260	COG3647	Membrane
AVCA_RS18275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVCA_RS18280	COG0436	Aminotransferase
AVCA_RS18300	COG1160	GTP binding
AVCA_RS18310	COG2976	Protein conserved in bacteria
AVCA_RS18315	COG0124	histidyl-tRNA synthetase
AVCA_RS18320	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AVCA_RS18340	COG0105	UTP biosynthetic process
AVCA_RS18355	COG0443	Heat shock 70 kDa protein
AVCA_RS18360	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AVCA_RS18365	COG0316	Belongs to the HesB IscA family
AVCA_RS18375	COG1104	cysteine desulfurase activity
AVCA_RS18410	COG1862	Preprotein translocase
AVCA_RS18415	COG0343	queuine tRNA-ribosyltransferase activity
AVCA_RS18420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AVCA_RS18430	COG0582	viral genome integration into host DNA
AVCA_RS18435	COG2801	Transposase and inactivated derivatives
AVCA_RS18475	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AVCA_RS18480	COG3657	addiction module killer protein
AVCA_RS18525	COG0268	Binds directly to 16S ribosomal RNA
AVCA_RS18535	COG3045	CreA protein
AVCA_RS18540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AVCA_RS18545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AVCA_RS18550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AVCA_RS18555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AVCA_RS18560	COG0142	geranyltranstransferase activity
AVCA_RS18565	COG0545	Peptidyl-prolyl cis-trans isomerase
AVCA_RS18570	COG2862	Uncharacterized protein family, UPF0114
AVCA_RS18580	COG1067	ATP-dependent peptidase activity
AVCA_RS18620	COG1595	DNA-templated transcription, initiation
AVCA_RS18625	COG0488	(ABC) transporter
AVCA_RS18630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AVCA_RS18635	COG0523	cobalamin synthesis protein
AVCA_RS18640	COG2879	small protein
AVCA_RS18645	COG1966	Carbon starvation protein
AVCA_RS18660	COG2020	methyltransferase activity
AVCA_RS18675	COG1970	mechanosensitive ion channel activity
AVCA_RS18680	COG0386	Belongs to the glutathione peroxidase family
AVCA_RS18690	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AVCA_RS18705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVCA_RS18720	COG1525	nuclease
AVCA_RS18725	COG2205	protein histidine kinase activity
AVCA_RS18725	COG2198	Histidine kinase
AVCA_RS18725	COG0784	Response regulator, receiver
AVCA_RS18735	COG2989	Protein conserved in bacteria
AVCA_RS18745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVCA_RS18750	COG2813	Specifically methylates the guanine in position
AVCA_RS18755	COG2119	membrane
AVCA_RS18760	COG2119	membrane
AVCA_RS18765	COG0501	Belongs to the peptidase M48B family
AVCA_RS18770	COG2135	peptidase activity
AVCA_RS18805	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AVCA_RS18810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AVCA_RS18815	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVCA_RS18820	COG1090	epimerase
AVCA_RS18825	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AVCA_RS18835	COG0789	Transcriptional regulator
AVCA_RS18840	COG0415	Belongs to the DNA photolyase family
AVCA_RS18845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AVCA_RS18850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AVCA_RS18860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AVCA_RS18865	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AVCA_RS18880	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AVCA_RS18895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AVCA_RS18900	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AVCA_RS18905	COG0193	aminoacyl-tRNA hydrolase activity
AVCA_RS18940	COG1025	Belongs to the peptidase M16 family
AVCA_RS18950	COG0535	radical SAM domain protein
AVCA_RS18960	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AVCA_RS18965	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AVCA_RS18970	COG3284	Transcriptional regulator
AVCA_RS18975	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS18980	COG3199	ATP-NAD kinase
AVCA_RS18985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AVCA_RS18990	COG0022	dehydrogenase e1 component
AVCA_RS19000	COG1063	alcohol dehydrogenase
AVCA_RS19015	COG1509	lysine 2,3-aminomutase activity
AVCA_RS19025	COG2801	Transposase and inactivated derivatives
AVCA_RS19045	COG2814	Major facilitator Superfamily
AVCA_RS19065	COG0659	secondary active sulfate transmembrane transporter activity
AVCA_RS19070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVCA_RS19090	COG3093	addiction module antidote protein HigA
AVCA_RS19105	COG0583	DNA-binding transcription factor activity
AVCA_RS19110	COG3135	benzoate transporter
AVCA_RS19120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVCA_RS19120	COG0543	2 iron, 2 sulfur cluster binding
AVCA_RS19125	COG2814	Major facilitator Superfamily
AVCA_RS19130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVCA_RS19135	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AVCA_RS19145	COG3971	2-oxopent-4-enoate hydratase activity
AVCA_RS19175	COG3384	dioxygenase
AVCA_RS19225	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AVCA_RS19235	COG1335	isochorismatase
AVCA_RS19245	COG0675	Transposase, IS605 OrfB family
AVCA_RS19255	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AVCA_RS19280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVCA_RS19285	COG3008	intermembrane lipid transfer
AVCA_RS19290	COG2995	paraquat-inducible protein a
AVCA_RS19295	COG2995	paraquat-inducible protein a
AVCA_RS19325	COG1183	phosphatidylcholine synthase activity
AVCA_RS19330	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AVCA_RS19340	COG0028	Belongs to the TPP enzyme family
AVCA_RS19350	COG3098	single-species biofilm formation
AVCA_RS19360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AVCA_RS19380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVCA_RS19390	COG1489	DNA binding
AVCA_RS19395	COG0436	Aminotransferase
AVCA_RS19400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AVCA_RS19405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVCA_RS19415	COG3852	Histidine kinase
AVCA_RS19425	COG0617	tRNA 3'-terminal CCA addition
AVCA_RS19440	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AVCA_RS19445	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AVCA_RS19450	COG0166	Belongs to the GPI family
AVCA_RS19470	COG1185	polyribonucleotide nucleotidyltransferase activity
AVCA_RS19475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AVCA_RS19485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AVCA_RS19490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AVCA_RS19495	COG0195	Participates in both transcription termination and antitermination
AVCA_RS19500	COG0779	Required for maturation of 30S ribosomal subunits
AVCA_RS19515	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AVCA_RS19520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AVCA_RS19525	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AVCA_RS19530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVCA_RS19535	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AVCA_RS19560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AVCA_RS19565	COG0484	heat shock protein binding
AVCA_RS19570	COG0443	Heat shock 70 kDa protein
AVCA_RS19575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AVCA_RS19580	COG0497	DNA recombination
AVCA_RS19590	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVCA_RS19595	COG2914	Belongs to the UPF0125 (RnfH) family
AVCA_RS19605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AVCA_RS19610	COG2186	Transcriptional regulator
AVCA_RS19615	COG1620	l-lactate permease
AVCA_RS19620	COG0247	lactate metabolic process
AVCA_RS19625	COG1139	Iron-sulfur cluster binding protein
AVCA_RS19640	COG2205	protein histidine kinase activity
AVCA_RS19675	COG0528	UMP kinase activity
AVCA_RS19680	COG0528	UMP kinase activity
AVCA_RS19685	COG3960	tartronate-semialdehyde synthase activity
AVCA_RS19690	COG0583	DNA-binding transcription factor activity
AVCA_RS19695	COG0281	malic enzyme
AVCA_RS19700	COG1620	l-lactate permease
AVCA_RS19705	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AVCA_RS19710	COG3193	protein, possibly involved in utilization of glycolate and propanediol
AVCA_RS19715	COG0247	lactate metabolic process
AVCA_RS19720	COG0277	FAD linked oxidase domain protein
AVCA_RS19725	COG0277	FAD linked oxidase domain protein
AVCA_RS19730	COG2186	Transcriptional regulator
AVCA_RS19735	COG0148	phosphopyruvate hydratase activity
AVCA_RS19745	COG3835	regulator
AVCA_RS19750	COG1929	Belongs to the glycerate kinase type-1 family
AVCA_RS19755	COG3960	tartronate-semialdehyde synthase activity
AVCA_RS19760	COG3622	Belongs to the hyi family
AVCA_RS19765	COG2084	Dehydrogenase
AVCA_RS19770	COG1741	Belongs to the pirin family
AVCA_RS19795	COG3150	esterase
AVCA_RS19800	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AVCA_RS19810	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVCA_RS19850	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVCA_RS19855	COG1129	ABC transporter
AVCA_RS19870	COG1960	acyl-CoA dehydrogenase activity
AVCA_RS19880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVCA_RS19890	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVCA_RS19890	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVCA_RS19955	COG0626	cystathionine gamma-synthase activity
AVCA_RS19965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA_RS19975	COG3829	transcription factor binding
AVCA_RS19990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA_RS20000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA_RS20045	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AVCA_RS20060	COG2995	paraquat-inducible protein a
AVCA_RS20065	COG2995	paraquat-inducible protein a
AVCA_RS20070	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AVCA_RS20070	COG3008	intermembrane lipid transfer
AVCA_RS20075	COG2963	transposase activity
AVCA_RS20095	COG1595	DNA-templated transcription, initiation
AVCA_RS20105	COG0628	permease
AVCA_RS20135	COG1132	(ABC) transporter
AVCA_RS20140	COG0156	8-amino-7-oxononanoate synthase activity
AVCA_RS20145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVCA_RS20160	COG0456	acetyltransferase
AVCA_RS20170	COG1213	nucleotidyl transferase
AVCA_RS20185	COG1183	phosphatidylcholine synthase activity
AVCA_RS20235	COG1216	Glycosyl transferase, family 2
AVCA_RS20235	COG0463	Glycosyl transferase, family 2
AVCA_RS20255	COG0583	DNA-binding transcription factor activity
AVCA_RS20270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVCA_RS20290	COG0494	nUDIX hydrolase
AVCA_RS20300	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AVCA_RS20305	COG1519	Transferase
AVCA_RS20315	COG0667	Aldo Keto reductase
AVCA_RS20340	COG2755	lipolytic protein G-D-S-L family
AVCA_RS20340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AVCA_RS20345	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AVCA_RS20345	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AVCA_RS20360	COG1132	(ABC) transporter
AVCA_RS20375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AVCA_RS20380	COG1442	glycosyl transferase family 8
AVCA_RS20395	COG0438	transferase activity, transferring glycosyl groups
AVCA_RS20400	COG2192	nodulation
AVCA_RS20420	COG0438	transferase activity, transferring glycosyl groups
AVCA_RS20425	COG0859	PFAM glycosyl transferase family 9
AVCA_RS20430	COG0859	PFAM glycosyl transferase family 9
AVCA_RS20465	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVCA_RS20485	COG2026	Addiction module toxin, RelE StbE family
AVCA_RS20505	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AVCA_RS20510	COG0583	DNA-binding transcription factor activity
AVCA_RS20520	COG1942	4-Oxalocrotonate Tautomerase
AVCA_RS20525	COG3263	regulation of cellular component size
AVCA_RS20530	COG1196	nuclear chromosome segregation
AVCA_RS20530	COG3264	Mechanosensitive ion channel
AVCA_RS20535	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AVCA_RS20545	COG0730	response to heat
AVCA_RS20550	COG3118	belongs to the thioredoxin family
AVCA_RS20560	COG1192	Involved in chromosome partitioning
AVCA_RS20565	COG0583	DNA-binding transcription factor activity
AVCA_RS20570	COG2814	Major facilitator Superfamily
AVCA_RS20575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AVCA_RS20580	COG0493	'glutamate synthase
AVCA_RS20585	COG0070	glutamate synthase
AVCA_RS20585	COG0069	glutamate synthase activity
AVCA_RS20585	COG0067	glutamate synthase
AVCA_RS20595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AVCA_RS20600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AVCA_RS20640	COG0281	malic enzyme
AVCA_RS20645	COG0254	rRNA binding
AVCA_RS20650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AVCA_RS20655	COG0018	arginyl-trna synthetase
AVCA_RS20665	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AVCA_RS20670	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AVCA_RS20680	COG2226	methyltransferase
AVCA_RS20690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AVCA_RS20695	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AVCA_RS20700	COG0140	phosphoribosyl-ATP diphosphatase activity
AVCA_RS20705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVCA_RS20710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVCA_RS20750	COG1490	D-aminoacyl-tRNA deacylase activity
AVCA_RS20765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AVCA_RS20790	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AVCA_RS20795	COG0058	SHG alpha-glucan phosphorylase activity
AVCA_RS20825	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AVCA_RS20845	COG0148	phosphopyruvate hydratase activity
AVCA_RS20850	COG0149	triose-phosphate isomerase activity
AVCA_RS20875	COG3344	reverse transcriptase
AVCA_RS20880	COG1217	gtp-binding protein TYPA
AVCA_RS20885	COG0301	tRNA thio-modification
AVCA_RS20885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVCA_RS20905	COG3852	Histidine kinase
AVCA_RS20915	COG0450	alkyl hydroperoxide reductase
AVCA_RS20920	COG1960	acyl-CoA dehydrogenase activity
AVCA_RS20930	COG0778	Nitroreductase
AVCA_RS20935	COG0716	FMN binding
AVCA_RS20970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AVCA_RS20975	COG0739	heme binding
AVCA_RS20980	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AVCA_RS20985	COG3344	reverse transcriptase
AVCA_RS20990	COG0316	Belongs to the HesB IscA family
AVCA_RS20995	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AVCA_RS21000	COG1981	membrane
AVCA_RS21005	COG0537	adenosine 5'-monophosphoramidase activity
AVCA_RS21010	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AVCA_RS21015	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AVCA_RS21020	COG1765	OsmC-like protein
AVCA_RS21040	COG0134	indole-3-glycerol-phosphate synthase activity
AVCA_RS21045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AVCA_RS21050	COG0512	Glutamine amidotransferase of anthranilate synthase
AVCA_RS21060	COG0586	Pfam SNARE associated Golgi protein
AVCA_RS21070	COG0022	dehydrogenase e1 component
AVCA_RS21070	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVCA_RS21075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AVCA_RS21085	COG0789	Transcriptional regulator
AVCA_RS21100	COG1335	isochorismatase
AVCA_RS21115	COG2249	NAD(P)H dehydrogenase (quinone) activity
AVCA_RS21125	COG2169	Transcriptional regulator
AVCA_RS21125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AVCA_RS21140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVCA_RS21150	COG4935	Belongs to the peptidase S8 family
AVCA_RS21150	COG1404	Belongs to the peptidase S8 family
AVCA_RS21165	COG0477	Major facilitator Superfamily
AVCA_RS21175	COG1538	Outer membrane efflux protein
AVCA_RS21185	COG0384	phenazine biosynthesis protein PhzF
AVCA_RS21195	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AVCA_RS21210	COG0583	DNA-binding transcription factor activity
AVCA_RS21285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AVCA_RS21290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AVCA_RS21295	COG0583	DNA-binding transcription factor activity
AVCA_RS21305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVCA_RS21310	COG0477	Major facilitator Superfamily
AVCA_RS21325	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA_RS21330	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AVCA_RS21335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AVCA_RS21345	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AVCA_RS21365	COG2967	ApaG domain
AVCA_RS21370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AVCA_RS21375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVCA_RS21380	COG2766	serine protein kinase
AVCA_RS21385	COG2718	Belongs to the UPF0229 family
AVCA_RS21390	COG2719	SpoVR family
AVCA_RS21395	COG0617	tRNA 3'-terminal CCA addition
AVCA_RS21410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVCA_RS21420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AVCA_RS21425	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AVCA_RS21430	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AVCA_RS21440	COG0358	DNA primase activity
AVCA_RS21445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AVCA_RS21450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVCA_RS21470	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AVCA_RS21485	COG1058	Belongs to the CinA family
AVCA_RS21485	COG1546	Belongs to the CinA family
AVCA_RS21490	COG3546	catalase activity
AVCA_RS21525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVCA_RS21530	COG1120	ATPase activity
AVCA_RS21535	COG1595	DNA-templated transcription, initiation
AVCA_RS21540	COG3712	iron ion homeostasis
AVCA_RS21545	COG4772	TonB-dependent receptor
AVCA_RS21555	COG2267	carboxylic ester hydrolase activity
AVCA_RS21580	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVCA_RS21580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVCA_RS21595	COG1178	ABC-type Fe3 transport system permease component
AVCA_RS21605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVCA_RS21610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVCA_RS21615	COG0006	proline dipeptidase activity
AVCA_RS21620	COG3079	Belongs to the UPF0149 family
AVCA_RS21635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AVCA_RS21650	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AVCA_RS21665	COG0248	Ppx GppA phosphatase
AVCA_RS21670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AVCA_RS21680	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AVCA_RS21685	COG1671	Belongs to the UPF0178 family
AVCA_RS21700	COG0861	Integral membrane protein TerC family
AVCA_RS21705	COG0488	(ABC) transporter
AVCA_RS21755	COG0165	Argininosuccinate lyase
AVCA_RS21775	COG1965	Belongs to the frataxin family
AVCA_RS21790	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AVCA_RS21800	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AVCA_RS21820	COG0432	Pfam Uncharacterised protein family UPF0047
AVCA_RS21825	COG0004	ammonium transporteR
AVCA_RS21830	COG0347	Belongs to the P(II) protein family
AVCA_RS21835	COG2960	long-chain fatty acid transporting porin activity
AVCA_RS21840	COG0606	chelatase, subunit chli
AVCA_RS21850	COG0583	DNA-binding transcription factor activity
AVCA_RS21860	COG1741	Belongs to the pirin family
AVCA_RS21895	COG0753	catalase activity
AVCA_RS21900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AVCA_RS21925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVCA_RS21935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVCA_RS21945	COG1012	belongs to the aldehyde dehydrogenase family
AVCA_RS21950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AVCA_RS21955	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AVCA_RS21960	COG0747	negative chemotaxis
AVCA_RS21970	COG2177	Part of the ABC transporter FtsEX involved in
AVCA_RS21975	COG2884	Cell division ATP-binding protein ftsE
AVCA_RS21980	COG0552	protein localization to endoplasmic reticulum
AVCA_RS21990	COG0584	glycerophosphoryl diester phosphodiesterase
AVCA_RS22000	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AVCA_RS22005	COG0697	spore germination
AVCA_RS22010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVCA_RS22015	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AVCA_RS22020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AVCA_RS22025	COG0730	response to heat
AVCA_RS22040	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
AVCA_RS22045	COG0494	nUDIX hydrolase
AVCA_RS22060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AVCA_RS22065	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AVCA_RS22075	COG0179	Fumarylacetoacetate (FAA) hydrolase
AVCA_RS22080	COG0277	FAD linked oxidase domain protein
AVCA_RS22085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVCA_RS22090	COG0679	Auxin Efflux Carrier
AVCA_RS22095	COG3180	Ammonia monooxygenase
AVCA_RS22130	COG0583	DNA-binding transcription factor activity
AVCA_RS22135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AVCA_RS22165	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AVCA_RS22180	COG1253	flavin adenine dinucleotide binding
AVCA_RS22185	COG0739	heme binding
AVCA_RS22200	COG0581	inorganic phosphate transmembrane transporter activity
AVCA_RS22205	COG0573	inorganic phosphate transmembrane transporter activity
AVCA_RS22215	COG1607	acyl-coa hydrolase
AVCA_RS22220	COG0676	glucose-6-phosphate 1-epimerase activity
AVCA_RS22255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVCA_RS22275	COG1177	transmembrane transport
AVCA_RS22280	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVCA_RS22285	COG3842	ATPase activity
AVCA_RS22300	COG3547	Transposase (IS116 IS110 IS902 family)
AVCA_RS22305	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AVCA_RS22315	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
AVCA_RS22325	COG0174	glutamine synthetase
AVCA_RS22330	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AVCA_RS22335	COG0174	glutamine synthetase
AVCA_RS22345	COG2957	Belongs to the agmatine deiminase family
AVCA_RS22350	COG0640	Transcriptional regulator
AVCA_RS22360	COG3706	GGDEF domain
AVCA_RS22430	COG3909	cytochrome
AVCA_RS22445	COG0667	Aldo Keto reductase
AVCA_RS22475	COG0596	Alpha beta hydrolase
AVCA_RS22515	COG1012	belongs to the aldehyde dehydrogenase family
AVCA_RS22530	COG0165	Argininosuccinate lyase
AVCA_RS22535	COG1301	dicarboxylic acid transport
AVCA_RS22540	COG0583	DNA-binding transcription factor activity
AVCA_RS22610	COG3180	Ammonia monooxygenase
AVCA_RS22625	COG1024	Enoyl-CoA hydratase
AVCA_RS22630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AVCA_RS22635	COG1960	acyl-CoA dehydrogenase activity
AVCA_RS22640	COG0789	Transcriptional regulator
AVCA_RS22650	COG2851	Citrate transporter
AVCA_RS22655	COG0861	Integral membrane protein TerC family
AVCA_RS22785	COG3293	Transposase
AVCA_RS22800	COG0679	Auxin Efflux Carrier
AVCA_RS22805	COG0149	triose-phosphate isomerase activity
AVCA_RS22820	COG0697	spore germination
AVCA_RS22830	COG0149	triose-phosphate isomerase activity
AVCA_RS22835	COG0148	phosphopyruvate hydratase activity
AVCA_RS22860	COG3718	enzyme involved in inositol metabolism
AVCA_RS22865	COG0477	Major facilitator Superfamily
AVCA_RS22865	COG2814	Major facilitator Superfamily
AVCA_RS22880	COG3962	Belongs to the TPP enzyme family
AVCA_RS22885	COG0673	inositol 2-dehydrogenase activity
AVCA_RS22890	COG1082	Xylose isomerase domain protein TIM barrel
AVCA_RS22895	COG1879	ABC-type sugar transport system periplasmic component
AVCA_RS22930	COG0625	glutathione transferase activity
AVCA_RS22940	COG1609	Transcriptional regulator
AVCA_RS22960	COG0673	inositol 2-dehydrogenase activity
AVCA_RS22965	COG4580	involved in the transport of maltose and maltodextrins
AVCA_RS22975	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVCA_RS22980	COG1129	ABC transporter
AVCA_RS22990	COG1120	ATPase activity
AVCA_RS22995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVCA_RS23115	COG2801	Transposase and inactivated derivatives
AVCA_RS23115	COG3415	Transposase
AVCA_RS23125	COG2205	protein histidine kinase activity
AVCA_RS23125	COG0784	Response regulator, receiver
AVCA_RS23125	COG5002	protein histidine kinase activity
AVCA_RS23130	COG3437	response regulator, receiver
AVCA_RS23170	COG4149	molybdate abc transporter
AVCA_RS23270	COG2914	Belongs to the UPF0125 (RnfH) family
AVCA_RS23275	COG4660	Part of a membrane complex involved in electron transport
AVCA_RS23290	COG4656	Part of a membrane complex involved in electron transport
AVCA_RS23295	COG2878	Part of a membrane complex involved in electron transport
AVCA_RS23300	COG4657	Part of a membrane complex involved in electron transport
AVCA_RS23340	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AVCA_RS23350	COG3604	Transcriptional regulator
AVCA_RS23360	COG1125	glycine betaine transport
AVCA_RS23360	COG0517	IMP dehydrogenase activity
AVCA_RS23365	COG2116	formate transmembrane transporter activity
AVCA_RS23370	COG2271	Major facilitator Superfamily
AVCA_RS23420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVCA_RS23430	COG2271	Major facilitator Superfamily
AVCA_RS23435	COG4948	Mandelate Racemase Muconate Lactonizing
AVCA_RS23440	COG0800	Aldolase
AVCA_RS23450	COG1414	Transcriptional regulator
AVCA_RS23460	COG4580	involved in the transport of maltose and maltodextrins
AVCA_RS23465	COG2207	Transcriptional regulator
AVCA_RS23475	COG1486	melibiose metabolic process
AVCA_RS23480	COG2211	Major facilitator Superfamily
AVCA_RS23490	COG3386	PFAM SMP-30 Gluconolaconase
AVCA_RS23500	COG0366	Alpha amylase catalytic
AVCA_RS23505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AVCA_RS23520	COG0667	Aldo Keto reductase
AVCA_RS23535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVCA_RS23540	COG1538	Outer membrane efflux protein
AVCA_RS23545	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVCA_RS23560	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AVCA_RS23590	COG0840	transmembrane signaling receptor activity
AVCA_RS23600	COG2852	Protein conserved in bacteria
AVCA_RS23605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AVCA_RS23610	COG1074	ATP-dependent DNA helicase activity
AVCA_RS23615	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AVCA_RS23630	COG1272	protein, Hemolysin III
AVCA_RS23635	COG1082	Xylose isomerase domain protein TIM barrel
AVCA_RS23680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AVCA_RS23685	COG1349	DNA-binding transcription factor activity
AVCA_RS23695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AVCA_RS23710	COG0601	transmembrane transport
AVCA_RS23715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVCA_RS23720	COG4172	Belongs to the ABC transporter superfamily
AVCA_RS23745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AVCA_RS23785	COG4771	TonB-dependent receptor
AVCA_RS23800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AVCA_RS23805	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AVCA_RS23810	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AVCA_RS23815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AVCA_RS23820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AVCA_RS23825	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AVCA_RS23835	COG0356	it plays a direct role in the translocation of protons across the membrane
AVCA_RS23840	COG3312	ion transport
AVCA_RS23845	COG1475	DNA binding
AVCA_RS23850	COG1192	Involved in chromosome partitioning
AVCA_RS23855	COG0357	Ribosomal RNA small subunit methyltransferase G
AVCA_RS23860	COG0445	tRNA wobble uridine modification
AVCA_RS23890	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AVCA_RS23910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AVCA_RS23935	COG0706	membrane insertase activity
AVCA_RS23940	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AVCA_RS23945	COG0594	ribonuclease P activity
AVCA_RS23950	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AVCA_RS23970	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AVCA_RS24050	COG0583	DNA-binding transcription factor activity