locus-tag	class	description
AVCA6_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AVCA6_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AVCA6_RS00040	COG2837	iron assimilation
AVCA6_RS00055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AVCA6_RS00060	COG0751	glycine-tRNA ligase activity
AVCA6_RS00070	COG2818	Glycosylase
AVCA6_RS00075	COG1525	nuclease
AVCA6_RS00075	COG4085	toxin activity
AVCA6_RS00075	COG0737	Belongs to the 5'-nucleotidase family
AVCA6_RS00080	COG0569	domain protein
AVCA6_RS00085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AVCA6_RS00095	COG0242	peptide deformylase activity
AVCA6_RS00105	COG0758	DNA mediated transformation
AVCA6_RS00110	COG0009	L-threonylcarbamoyladenylate synthase
AVCA6_RS00120	COG0408	coproporphyrinogen oxidase activity
AVCA6_RS00125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVCA6_RS00140	COG2132	Multicopper oxidase
AVCA6_RS00150	COG1285	pathogenesis
AVCA6_RS00195	COG0655	NAD(P)H dehydrogenase (quinone) activity
AVCA6_RS00200	COG0700	Nucleoside recognition
AVCA6_RS00215	COG3706	GGDEF domain
AVCA6_RS00245	COG1126	abc transporter atp-binding protein
AVCA6_RS00260	COG0210	DNA helicase
AVCA6_RS00270	COG0826	peptidase U32
AVCA6_RS00285	COG0842	Transport permease protein
AVCA6_RS00290	COG0842	Transport permease protein
AVCA6_RS00295	COG1131	(ABC) transporter
AVCA6_RS00305	COG1309	transcriptional regulator
AVCA6_RS00325	COG2945	thiolester hydrolase activity
AVCA6_RS00325	COG0596	Alpha beta hydrolase
AVCA6_RS00360	COG0675	Transposase, IS605 OrfB family
AVCA6_RS00380	COG1335	isochorismatase
AVCA6_RS00395	COG1305	Transglutaminase-like
AVCA6_RS00400	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AVCA6_RS00405	COG0735	belongs to the Fur family
AVCA6_RS00410	COG1121	(ABC) transporter
AVCA6_RS00415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AVCA6_RS00455	COG0109	protoheme IX farnesyltransferase activity
AVCA6_RS00460	COG1612	heme a metabolic process
AVCA6_RS00485	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AVCA6_RS00490	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVCA6_RS00505	COG0659	secondary active sulfate transmembrane transporter activity
AVCA6_RS00535	COG3712	iron ion homeostasis
AVCA6_RS00545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AVCA6_RS00570	COG0252	asparaginase activity
AVCA6_RS00590	COG1686	Belongs to the peptidase S11 family
AVCA6_RS00605	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AVCA6_RS00630	COG2814	Major facilitator Superfamily
AVCA6_RS00635	COG0318	PFAM AMP-dependent synthetase and ligase
AVCA6_RS00635	COG0204	Acyl-transferase
AVCA6_RS00715	COG3411	Ferredoxin
AVCA6_RS00815	COG0523	cobalamin synthesis protein
AVCA6_RS00825	COG1607	acyl-coa hydrolase
AVCA6_RS00835	COG1283	sodium-dependent phosphate transmembrane transporter activity
AVCA6_RS00845	COG1764	response to oxidative stress
AVCA6_RS00905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVCA6_RS00950	COG3023	N-Acetylmuramoyl-L-alanine amidase
AVCA6_RS00970	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AVCA6_RS00975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AVCA6_RS00985	COG0583	DNA-binding transcription factor activity
AVCA6_RS00990	COG0439	Biotin carboxylase
AVCA6_RS00995	COG5016	pyruvate
AVCA6_RS00995	COG0511	ligase activity, forming carbon-carbon bonds
AVCA6_RS01000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA6_RS01020	COG0133	tryptophan synthase activity
AVCA6_RS01025	COG0159	tryptophan synthase activity
AVCA6_RS01045	COG0484	heat shock protein binding
AVCA6_RS01050	COG0789	Transcriptional regulator
AVCA6_RS01055	COG0730	response to heat
AVCA6_RS01080	COG1595	DNA-templated transcription, initiation
AVCA6_RS01105	COG2356	endonuclease I
AVCA6_RS01115	COG3237	CsbD-like
AVCA6_RS01125	COG0789	Transcriptional regulator
AVCA6_RS01140	COG2982	Protein involved in outer membrane biogenesis
AVCA6_RS01150	COG0778	Nitroreductase
AVCA6_RS01155	COG1136	(ABC) transporter
AVCA6_RS01155	COG0577	efflux transmembrane transporter activity
AVCA6_RS01180	COG0366	Alpha amylase catalytic
AVCA6_RS01200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AVCA6_RS01205	COG2841	Protein conserved in bacteria
AVCA6_RS01220	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AVCA6_RS01225	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AVCA6_RS01275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AVCA6_RS01320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AVCA6_RS01325	COG1758	RNA polymerase activity
AVCA6_RS01335	COG1561	YicC-like family, N-terminal region
AVCA6_RS01340	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AVCA6_RS01350	COG0708	Exodeoxyribonuclease III
AVCA6_RS01355	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AVCA6_RS01365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AVCA6_RS01375	COG0756	dUTP diphosphatase activity
AVCA6_RS01380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AVCA6_RS01385	COG2003	Belongs to the UPF0758 family
AVCA6_RS01390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AVCA6_RS01395	COG2363	Small membrane protein
AVCA6_RS01405	COG2022	thiamine diphosphate biosynthetic process
AVCA6_RS01410	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AVCA6_RS01415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AVCA6_RS01430	COG2813	Specifically methylates the guanine in position
AVCA6_RS01430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVCA6_RS01435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVCA6_RS01440	COG1872	DUF167
AVCA6_RS01475	COG0540	Belongs to the ATCase OTCase family
AVCA6_RS01485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AVCA6_RS01510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AVCA6_RS01530	COG3038	cytochrome b561
AVCA6_RS01535	COG2353	YceI-like domain
AVCA6_RS01545	COG2205	protein histidine kinase activity
AVCA6_RS01560	COG0129	dihydroxy-acid dehydratase activity
AVCA6_RS01575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AVCA6_RS01580	COG0842	Transport permease protein
AVCA6_RS01585	COG1131	(ABC) transporter
AVCA6_RS01590	COG0840	transmembrane signaling receptor activity
AVCA6_RS01595	COG0693	protein deglycase activity
AVCA6_RS01600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AVCA6_RS01630	COG0247	lactate metabolic process
AVCA6_RS01640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AVCA6_RS01645	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AVCA6_RS01650	COG0429	hydrolase of the alpha beta-hydrolase fold
AVCA6_RS01655	COG0742	ribosomal rna small subunit methyltransferase
AVCA6_RS01660	COG0612	Peptidase, M16
AVCA6_RS01665	COG0612	Peptidase, M16
AVCA6_RS01670	COG0513	Belongs to the DEAD box helicase family
AVCA6_RS01675	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AVCA6_RS01690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AVCA6_RS01695	COG0738	Major facilitator superfamily
AVCA6_RS01705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVCA6_RS01765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA6_RS01770	COG2814	Major facilitator Superfamily
AVCA6_RS01775	COG1902	pentaerythritol trinitrate reductase activity
AVCA6_RS01780	COG0583	DNA-binding transcription factor activity
AVCA6_RS01785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AVCA6_RS01790	COG0243	molybdopterin cofactor binding
AVCA6_RS01790	COG3383	formate dehydrogenase (NAD+) activity
AVCA6_RS01795	COG0437	4 iron, 4 sulfur cluster binding
AVCA6_RS01800	COG2864	formate dehydrogenase
AVCA6_RS01815	COG1595	DNA-templated transcription, initiation
AVCA6_RS01875	COG0583	DNA-binding transcription factor activity
AVCA6_RS01930	COG0346	lactoylglutathione lyase activity
AVCA6_RS01960	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
AVCA6_RS02035	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVCA6_RS02050	COG2194	sulfuric ester hydrolase activity
AVCA6_RS02080	COG1151	hydroxylamine reductase activity
AVCA6_RS02100	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AVCA6_RS02105	COG1194	a g-specific adenine glycosylase
AVCA6_RS02120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AVCA6_RS02130	COG0131	Imidazoleglycerol-phosphate dehydratase
AVCA6_RS02135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AVCA6_RS02145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AVCA6_RS02150	COG0107	imidazoleglycerol-phosphate synthase activity
AVCA6_RS02155	COG0793	Belongs to the peptidase S41A family
AVCA6_RS02160	COG4942	peptidase
AVCA6_RS02165	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AVCA6_RS02180	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AVCA6_RS02185	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AVCA6_RS02195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVCA6_RS02210	COG3218	ABC-type transport auxiliary lipoprotein component
AVCA6_RS02210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AVCA6_RS02215	COG1127	ABC transporter
AVCA6_RS02220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AVCA6_RS02225	COG3132	Protein of unknown function, DUF480
AVCA6_RS02240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AVCA6_RS02260	COG0306	phosphate transporter
AVCA6_RS02275	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AVCA6_RS02275	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AVCA6_RS02285	COG5001	Diguanylate cyclase
AVCA6_RS02285	COG5002	protein histidine kinase activity
AVCA6_RS02285	COG3447	MASE1 domain protein
AVCA6_RS02320	COG2918	glutathione biosynthetic process
AVCA6_RS02330	COG2183	response to ionizing radiation
AVCA6_RS02335	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AVCA6_RS02345	COG0457	Tetratricopeptide repeat
AVCA6_RS02375	COG0189	ligase activity
AVCA6_RS02380	COG0189	ligase activity
AVCA6_RS02380	COG4067	protein conserved in archaea
AVCA6_RS02385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AVCA6_RS02400	COG1012	belongs to the aldehyde dehydrogenase family
AVCA6_RS02405	COG2186	Transcriptional regulator
AVCA6_RS02410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVCA6_RS02415	COG2271	Major facilitator Superfamily
AVCA6_RS02420	COG2721	sulfolactate sulfo-lyase activity
AVCA6_RS02425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVCA6_RS02510	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AVCA6_RS02530	COG1011	Hydrolase
AVCA6_RS02535	COG0494	nUDIX hydrolase
AVCA6_RS02540	COG1218	3'(2'),5'-bisphosphate nucleotidase
AVCA6_RS02550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AVCA6_RS02555	COG2226	methyltransferase
AVCA6_RS02570	COG0126	phosphoglycerate kinase activity
AVCA6_RS02580	COG4702	Belongs to the UPF0303 family
AVCA6_RS02585	COG0673	inositol 2-dehydrogenase activity
AVCA6_RS02590	COG1349	DNA-binding transcription factor activity
AVCA6_RS02595	COG1451	nucleotide metabolic process
AVCA6_RS02605	COG2354	Protein conserved in bacteria
AVCA6_RS02620	COG1289	transmembrane transporter activity
AVCA6_RS02630	COG0330	HflC and HflK could
AVCA6_RS02635	COG0686	Belongs to the AlaDH PNT family
AVCA6_RS02640	COG1309	transcriptional regulator
AVCA6_RS02650	COG0625	glutathione transferase activity
AVCA6_RS02660	COG2814	Major facilitator Superfamily
AVCA6_RS02685	COG0204	Acyl-transferase
AVCA6_RS02695	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AVCA6_RS02735	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AVCA6_RS02740	COG1040	competence protein
AVCA6_RS02745	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AVCA6_RS02750	COG0156	8-amino-7-oxononanoate synthase activity
AVCA6_RS02755	COG2226	methyltransferase
AVCA6_RS02755	COG1073	alpha beta
AVCA6_RS02765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AVCA6_RS02775	COG4589	Belongs to the CDS family
AVCA6_RS02780	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AVCA6_RS02780	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AVCA6_RS02785	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AVCA6_RS02830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AVCA6_RS02835	COG0081	regulation of translation
AVCA6_RS02840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AVCA6_RS02845	COG0222	ribosome binding
AVCA6_RS02850	COG0085	RNA polymerase activity
AVCA6_RS02855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AVCA6_RS02860	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AVCA6_RS02865	COG0049	tRNA binding
AVCA6_RS02880	COG0051	transcription antitermination factor activity, RNA binding
AVCA6_RS02885	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AVCA6_RS02890	COG0088	Forms part of the polypeptide exit tunnel
AVCA6_RS02895	COG0089	rRNA binding
AVCA6_RS02900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AVCA6_RS02905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AVCA6_RS02910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AVCA6_RS02915	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AVCA6_RS02920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AVCA6_RS02925	COG0255	Belongs to the universal ribosomal protein uL29 family
AVCA6_RS02930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AVCA6_RS02935	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AVCA6_RS02940	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AVCA6_RS02945	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AVCA6_RS02950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AVCA6_RS02955	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AVCA6_RS02960	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AVCA6_RS02965	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AVCA6_RS02970	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AVCA6_RS02975	COG1841	ribosomal large subunit assembly
AVCA6_RS02980	COG0200	Binds to the 23S rRNA
AVCA6_RS02990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AVCA6_RS02995	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AVCA6_RS03005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AVCA6_RS03010	COG0202	RNA polymerase activity
AVCA6_RS03015	COG0203	ribosomal protein L17
AVCA6_RS03025	COG2814	Major facilitator Superfamily
AVCA6_RS03035	COG0583	DNA-binding transcription factor activity
AVCA6_RS03040	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS03050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVCA6_RS03055	COG3047	cAMP biosynthetic process
AVCA6_RS03060	COG3047	cAMP biosynthetic process
AVCA6_RS03075	COG4181	ATPase activity
AVCA6_RS03090	COG3118	belongs to the thioredoxin family
AVCA6_RS03095	COG2264	protein methyltransferase activity
AVCA6_RS03105	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AVCA6_RS03110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVCA6_RS03110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVCA6_RS03125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AVCA6_RS03135	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AVCA6_RS03140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AVCA6_RS03150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVCA6_RS03155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVCA6_RS03165	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AVCA6_RS03175	COG0443	Heat shock 70 kDa protein
AVCA6_RS03190	COG0138	bifunctional purine biosynthesis protein purh
AVCA6_RS03210	COG2264	protein methyltransferase activity
AVCA6_RS03245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVCA6_RS03260	COG0023	Translation Initiation Factor
AVCA6_RS03265	COG1166	arginine decarboxylase activity
AVCA6_RS03270	COG0534	Mate efflux family protein
AVCA6_RS03280	COG0589	response to stress
AVCA6_RS03290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AVCA6_RS03345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVCA6_RS03360	COG1126	abc transporter atp-binding protein
AVCA6_RS03365	COG0765	amino acid transport
AVCA6_RS03370	COG0765	amino acid transport
AVCA6_RS03380	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AVCA6_RS03385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AVCA6_RS03410	COG3830	Belongs to the UPF0237 family
AVCA6_RS03410	COG0560	Phosphoserine phosphatase
AVCA6_RS03415	COG1063	alcohol dehydrogenase
AVCA6_RS03420	COG0688	phosphatidylethanolamine metabolic process
AVCA6_RS03430	COG1162	GTPase activity
AVCA6_RS03435	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AVCA6_RS03445	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AVCA6_RS03445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AVCA6_RS03450	COG0802	atpase or kinase
AVCA6_RS03455	COG0860	N-Acetylmuramoyl-L-alanine amidase
AVCA6_RS03460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AVCA6_RS03465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AVCA6_RS03470	COG1923	regulation of RNA biosynthetic process
AVCA6_RS03475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AVCA6_RS03480	COG0330	HflC and HflK could
AVCA6_RS03485	COG0330	HflC and HflK could
AVCA6_RS03495	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AVCA6_RS03500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AVCA6_RS03515	COG0557	exoribonuclease II activity
AVCA6_RS03520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVCA6_RS03525	COG0360	Binds together with S18 to 16S ribosomal RNA
AVCA6_RS03530	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AVCA6_RS03540	COG0359	binds to the 23S rRNA
AVCA6_RS03545	COG0305	Participates in initiation and elongation during chromosome replication
AVCA6_RS03560	COG2813	Specifically methylates the guanine in position
AVCA6_RS03570	COG1946	Acyl-CoA thioesterase
AVCA6_RS03575	COG0546	phosphoglycolate phosphatase activity
AVCA6_RS03580	COG2321	neutral zinc metallopeptidase
AVCA6_RS03595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AVCA6_RS03600	COG2252	PERMEase
AVCA6_RS03605	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AVCA6_RS03620	COG4206	TonB-dependent receptor
AVCA6_RS03625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AVCA6_RS03630	COG0142	geranyltranstransferase activity
AVCA6_RS03635	COG1722	exodeoxyribonuclease VII activity
AVCA6_RS03640	COG5001	Diguanylate cyclase
AVCA6_RS03640	COG3300	MHYT domain
AVCA6_RS03655	COG3228	Belongs to the MtfA family
AVCA6_RS03670	COG1454	alcohol dehydrogenase
AVCA6_RS03680	COG3284	Transcriptional regulator
AVCA6_RS03685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AVCA6_RS03720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVCA6_RS03725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA6_RS03735	COG4771	TonB-dependent receptor
AVCA6_RS03745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA6_RS03755	COG4771	TonB-dependent receptor
AVCA6_RS03795	COG0702	epimerase
AVCA6_RS03805	COG1346	cytolysis
AVCA6_RS03815	COG0366	Alpha amylase catalytic
AVCA6_RS03820	COG0586	Pfam SNARE associated Golgi protein
AVCA6_RS03825	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AVCA6_RS03830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AVCA6_RS03840	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AVCA6_RS03845	COG0768	penicillin binding
AVCA6_RS03850	COG0772	Belongs to the SEDS family
AVCA6_RS03855	COG2951	lytic endotransglycosylase activity
AVCA6_RS03865	COG1686	Belongs to the peptidase S11 family
AVCA6_RS03870	COG2921	Belongs to the UPF0250 family
AVCA6_RS03875	COG0321	lipoyl(octanoyl) transferase activity
AVCA6_RS03880	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AVCA6_RS03885	COG0028	Belongs to the TPP enzyme family
AVCA6_RS03890	COG2951	lytic endotransglycosylase activity
AVCA6_RS03905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVCA6_RS03945	COG2814	Major facilitator Superfamily
AVCA6_RS03970	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AVCA6_RS03990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVCA6_RS04100	COG0495	leucyl-tRNA aminoacylation
AVCA6_RS04110	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AVCA6_RS04115	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AVCA6_RS04125	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AVCA6_RS04130	COG1702	phosphate starvation-inducible protein PhoH
AVCA6_RS04140	COG3415	Transposase
AVCA6_RS04140	COG2801	Transposase and inactivated derivatives
AVCA6_RS04155	COG3254	rhamnose metabolic process
AVCA6_RS04175	COG4580	involved in the transport of maltose and maltodextrins
AVCA6_RS04180	COG2271	Major facilitator Superfamily
AVCA6_RS04185	COG4948	Mandelate Racemase Muconate Lactonizing
AVCA6_RS04195	COG1012	belongs to the aldehyde dehydrogenase family
AVCA6_RS04205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AVCA6_RS04210	COG0352	thiamine-phosphate diphosphorylase activity
AVCA6_RS04215	COG0351	phosphomethylpyrimidine kinase
AVCA6_RS04220	COG1960	acyl-CoA dehydrogenase activity
AVCA6_RS04225	COG0019	diaminopimelate decarboxylase activity
AVCA6_RS04235	COG2814	Major facilitator Superfamily
AVCA6_RS04240	COG4264	IucA IucC family
AVCA6_RS04250	COG4772	TonB-dependent receptor
AVCA6_RS04260	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AVCA6_RS04265	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AVCA6_RS04270	COG0830	nickel cation binding
AVCA6_RS04275	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AVCA6_RS04280	COG0673	inositol 2-dehydrogenase activity
AVCA6_RS04290	COG1301	dicarboxylic acid transport
AVCA6_RS04295	COG0596	Alpha beta hydrolase
AVCA6_RS04300	COG0583	DNA-binding transcription factor activity
AVCA6_RS04335	COG3293	Transposase
AVCA6_RS04370	COG1021	2,3-dihydroxybenzoate-AMP ligase
AVCA6_RS04375	COG1535	isochorismatase
AVCA6_RS04375	COG3433	isochorismatase activity
AVCA6_RS04395	COG2801	Transposase and inactivated derivatives
AVCA6_RS04415	COG0066	3-isopropylmalate dehydratase activity
AVCA6_RS04420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AVCA6_RS04445	COG0804	urea catabolic process
AVCA6_RS04450	COG0832	Belongs to the urease beta subunit family
AVCA6_RS04455	COG0831	urea catabolic process
AVCA6_RS04460	COG0829	nickel cation binding
AVCA6_RS04465	COG4303	Ethanolamine ammonia lyase large subunit
AVCA6_RS04470	COG4302	ethanolamine ammonia-lyase activity
AVCA6_RS04485	COG1522	sequence-specific DNA binding
AVCA6_RS04490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AVCA6_RS04500	COG1643	Atp-dependent helicase
AVCA6_RS04510	COG0513	Belongs to the DEAD box helicase family
AVCA6_RS04515	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AVCA6_RS04515	COG0493	'glutamate synthase
AVCA6_RS04520	COG0123	including yeast histone deacetylase and acetoin utilization protein
AVCA6_RS04545	COG1309	transcriptional regulator
AVCA6_RS04550	COG2814	Major facilitator Superfamily
AVCA6_RS04580	COG0628	permease
AVCA6_RS04595	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AVCA6_RS04610	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AVCA6_RS04615	COG1858	cytochrome C peroxidase
AVCA6_RS04630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AVCA6_RS04645	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AVCA6_RS04650	COG3052	prosthetic group binding
AVCA6_RS04670	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AVCA6_RS04700	COG1368	sulfuric ester hydrolase activity
AVCA6_RS04705	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AVCA6_RS04710	COG4774	siderophore transport
AVCA6_RS04725	COG4651	solute:proton antiporter activity
AVCA6_RS04725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AVCA6_RS04765	COG0745	RESPONSE REGULATOR receiver
AVCA6_RS04770	COG2205	protein histidine kinase activity
AVCA6_RS04775	COG0306	phosphate transporter
AVCA6_RS04785	COG0848	biopolymer transport protein
AVCA6_RS04805	COG0583	DNA-binding transcription factor activity
AVCA6_RS04810	COG1960	acyl-CoA dehydrogenase activity
AVCA6_RS04815	COG1024	Enoyl-CoA hydratase
AVCA6_RS04825	COG1024	Enoyl-CoA hydratase
AVCA6_RS04835	COG0583	DNA-binding transcription factor activity
AVCA6_RS04840	COG3719	Belongs to the RNase T2 family
AVCA6_RS04875	COG3223	Belongs to the PsiE family
AVCA6_RS04880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AVCA6_RS04885	COG3293	Transposase
AVCA6_RS04965	COG0628	permease
AVCA6_RS04980	COG1294	oxidase, subunit
AVCA6_RS04985	COG1271	oxidase subunit
AVCA6_RS04990	COG2323	membrane
AVCA6_RS05000	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS05005	COG3685	Protein conserved in bacteria
AVCA6_RS05015	COG2204	response regulator
AVCA6_RS05035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AVCA6_RS05035	COG2010	Cytochrome c
AVCA6_RS05040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVCA6_RS05060	COG3022	response to hydroperoxide
AVCA6_RS05070	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AVCA6_RS05075	COG0315	cyclic pyranopterin monophosphate synthase activity
AVCA6_RS05080	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AVCA6_RS05100	COG2801	Transposase and inactivated derivatives
AVCA6_RS05100	COG3415	Transposase
AVCA6_RS05110	COG2827	Endonuclease containing a URI domain
AVCA6_RS05130	COG0145	ligase activity
AVCA6_RS05135	COG4647	ligase activity
AVCA6_RS05140	COG0145	ligase activity
AVCA6_RS05150	COG0523	cobalamin synthesis protein
AVCA6_RS05160	COG3081	Nucleoid-associated protein
AVCA6_RS05170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVCA6_RS05180	COG0583	DNA-binding transcription factor activity
AVCA6_RS05190	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS05205	COG0420	3'-5' exonuclease activity
AVCA6_RS05210	COG0419	ATPase involved in DNA repair
AVCA6_RS05220	COG1253	flavin adenine dinucleotide binding
AVCA6_RS05230	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AVCA6_RS05255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AVCA6_RS05260	COG0795	lipopolysaccharide-transporting ATPase activity
AVCA6_RS05265	COG0795	lipopolysaccharide-transporting ATPase activity
AVCA6_RS05275	COG1278	Cold shock
AVCA6_RS05290	COG0728	peptidoglycan biosynthetic process
AVCA6_RS05295	COG0196	riboflavin kinase activity
AVCA6_RS05300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AVCA6_RS05305	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AVCA6_RS05310	COG1047	Peptidyl-prolyl cis-trans
AVCA6_RS05315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AVCA6_RS05350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVCA6_RS05405	COG1132	(ABC) transporter
AVCA6_RS05415	COG1252	NADH dehydrogenase
AVCA6_RS05440	COG0237	dephospho-CoA kinase activity
AVCA6_RS05445	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AVCA6_RS05470	COG3023	N-Acetylmuramoyl-L-alanine amidase
AVCA6_RS05480	COG0084	hydrolase, TatD family'
AVCA6_RS05500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVCA6_RS05500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVCA6_RS05505	COG1105	Belongs to the carbohydrate kinase PfkB family
AVCA6_RS05510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AVCA6_RS05510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AVCA6_RS05510	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AVCA6_RS05530	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AVCA6_RS05535	COG2831	hemolysin activation secretion protein
AVCA6_RS05550	COG0019	diaminopimelate decarboxylase activity
AVCA6_RS05555	COG4774	siderophore transport
AVCA6_RS05560	COG3128	pkhd-type hydroxylase
AVCA6_RS05595	COG3128	pkhd-type hydroxylase
AVCA6_RS05600	COG4774	siderophore transport
AVCA6_RS05615	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AVCA6_RS05620	COG1984	allophanate hydrolase subunit 2
AVCA6_RS05625	COG4608	Belongs to the ABC transporter superfamily
AVCA6_RS05630	COG0444	Belongs to the ABC transporter superfamily
AVCA6_RS05635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVCA6_RS05640	COG0601	transmembrane transport
AVCA6_RS05645	COG0747	negative chemotaxis
AVCA6_RS05660	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AVCA6_RS05680	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AVCA6_RS05685	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AVCA6_RS05690	COG0154	amidase activity
AVCA6_RS05695	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AVCA6_RS05700	COG1077	Cell shape determining protein MreB Mrl
AVCA6_RS05705	COG1792	Involved in formation and maintenance of cell shape
AVCA6_RS05710	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AVCA6_RS05715	COG0424	maF-like protein
AVCA6_RS05720	COG1530	ribonuclease E activity
AVCA6_RS05730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVCA6_RS05735	COG0312	modulator of DNA gyrase
AVCA6_RS05740	COG3028	Belongs to the UPF0307 family
AVCA6_RS05745	COG0312	modulator of DNA gyrase
AVCA6_RS05755	COG1660	Displays ATPase and GTPase activities
AVCA6_RS05775	COG1137	ATPase activity
AVCA6_RS05780	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AVCA6_RS05790	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AVCA6_RS05800	COG1127	ABC transporter
AVCA6_RS05805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AVCA6_RS05810	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AVCA6_RS05825	COG5007	Belongs to the BolA IbaG family
AVCA6_RS05830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AVCA6_RS05835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AVCA6_RS05840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AVCA6_RS05845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVCA6_RS05850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVCA6_RS05860	COG0175	sulfate reduction
AVCA6_RS05885	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AVCA6_RS05890	COG1515	deoxyribonuclease V activity
AVCA6_RS05895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AVCA6_RS05900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AVCA6_RS05905	COG0723	plastoquinol--plastocyanin reductase activity
AVCA6_RS05910	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AVCA6_RS05915	COG2857	Cytochrome c1
AVCA6_RS05920	COG0625	glutathione transferase activity
AVCA6_RS05925	COG2969	positive regulation of protein catabolic process
AVCA6_RS05930	COG2823	Periplasmic or secreted lipoprotein
AVCA6_RS05935	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AVCA6_RS05940	COG0792	nuclease activity
AVCA6_RS05955	COG2001	Belongs to the MraZ family
AVCA6_RS05960	COG0275	rRNA processing
AVCA6_RS05975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVCA6_RS05980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AVCA6_RS05985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AVCA6_RS05990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AVCA6_RS05995	COG0772	Belongs to the SEDS family
AVCA6_RS06000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AVCA6_RS06005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AVCA6_RS06010	COG1181	Belongs to the D-alanine--D-alanine ligase family
AVCA6_RS06030	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AVCA6_RS06040	COG0653	protein targeting
AVCA6_RS06055	COG0494	nUDIX hydrolase
AVCA6_RS06060	COG2096	Adenosyltransferase
AVCA6_RS06075	COG1666	GTP binding
AVCA6_RS06090	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS06095	COG0748	coenzyme F420 binding
AVCA6_RS06100	COG3030	protein affecting phage T7 exclusion by the F plasmid
AVCA6_RS06105	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AVCA6_RS06145	COG1024	Enoyl-CoA hydratase
AVCA6_RS06170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AVCA6_RS06210	COG3086	response to oxidative stress
AVCA6_RS06215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVCA6_RS06220	COG0481	GTPase activity
AVCA6_RS06235	COG0571	ribonuclease III activity
AVCA6_RS06240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AVCA6_RS06250	COG1381	Involved in DNA repair and RecF pathway recombination
AVCA6_RS06255	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AVCA6_RS06265	COG0500	methyltransferase
AVCA6_RS06270	COG2226	methyltransferase
AVCA6_RS06280	COG1414	Transcriptional regulator
AVCA6_RS06290	COG1454	alcohol dehydrogenase
AVCA6_RS06295	COG2610	gluconate transmembrane transporter activity
AVCA6_RS06300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AVCA6_RS06320	COG0583	DNA-binding transcription factor activity
AVCA6_RS06345	COG3842	ATPase activity
AVCA6_RS06355	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AVCA6_RS06365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AVCA6_RS06370	COG0418	dihydroorotase activity
AVCA6_RS06375	COG0137	argininosuccinate synthase activity
AVCA6_RS06415	COG0521	Mo-molybdopterin cofactor biosynthetic process
AVCA6_RS06420	COG0303	'Molybdopterin
AVCA6_RS06435	COG0488	(ABC) transporter
AVCA6_RS06440	COG0589	response to stress
AVCA6_RS06445	COG2814	Major facilitator Superfamily
AVCA6_RS06460	COG1024	Enoyl-CoA hydratase
AVCA6_RS06465	COG1012	belongs to the aldehyde dehydrogenase family
AVCA6_RS06470	COG3320	Male sterility
AVCA6_RS06470	COG1022	Amp-dependent synthetase and ligase
AVCA6_RS06480	COG1960	acyl-CoA dehydrogenase activity
AVCA6_RS06500	COG0745	RESPONSE REGULATOR receiver
AVCA6_RS06505	COG2205	protein histidine kinase activity
AVCA6_RS06510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVCA6_RS06515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVCA6_RS06555	COG1024	Enoyl-CoA hydratase
AVCA6_RS06555	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVCA6_RS06560	COG0183	Belongs to the thiolase family
AVCA6_RS06590	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AVCA6_RS06610	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AVCA6_RS06620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AVCA6_RS06635	COG1805	sodium ion transport
AVCA6_RS06650	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AVCA6_RS06660	COG1477	protein flavinylation
AVCA6_RS06670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVCA6_RS06675	COG0584	glycerophosphoryl diester phosphodiesterase
AVCA6_RS06685	COG1136	(ABC) transporter
AVCA6_RS06690	COG4591	ABC-type transport system involved in lipoprotein release permease component
AVCA6_RS06700	COG0658	competence protein
AVCA6_RS06700	COG2333	competence protein COMEC
AVCA6_RS06705	COG0811	peptide transport
AVCA6_RS06710	COG0848	biopolymer transport protein
AVCA6_RS06715	COG1663	tetraacyldisaccharide 4'-kinase activity
AVCA6_RS06720	COG2835	tetraacyldisaccharide 4'-kinase activity
AVCA6_RS06730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AVCA6_RS06735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AVCA6_RS06740	COG1530	ribonuclease E activity
AVCA6_RS06750	COG0546	phosphoglycolate phosphatase activity
AVCA6_RS06755	COG0616	signal peptide processing
AVCA6_RS06755	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AVCA6_RS06760	COG0424	maF-like protein
AVCA6_RS06770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AVCA6_RS06775	COG0416	fatty acid biosynthetic process
AVCA6_RS06790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVCA6_RS06795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVCA6_RS06805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AVCA6_RS06825	COG0084	hydrolase, TatD family'
AVCA6_RS06835	COG3293	Transposase
AVCA6_RS06840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVCA6_RS06850	COG1355	regulation of microtubule-based process
AVCA6_RS06855	COG1960	acyl-CoA dehydrogenase activity
AVCA6_RS06860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVCA6_RS06865	COG2267	carboxylic ester hydrolase activity
AVCA6_RS06870	COG1414	Transcriptional regulator
AVCA6_RS06875	COG3971	2-oxopent-4-enoate hydratase activity
AVCA6_RS06880	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AVCA6_RS06885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVCA6_RS06890	COG2814	Major facilitator Superfamily
AVCA6_RS06950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AVCA6_RS06955	COG1764	response to oxidative stress
AVCA6_RS06960	COG1846	Transcriptional regulator
AVCA6_RS06970	COG0730	response to heat
AVCA6_RS06985	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AVCA6_RS06995	COG0500	methyltransferase
AVCA6_RS07005	COG0501	Belongs to the peptidase M48B family
AVCA6_RS07010	COG0436	Aminotransferase
AVCA6_RS07015	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVCA6_RS07020	COG0386	Belongs to the glutathione peroxidase family
AVCA6_RS07025	COG3437	response regulator, receiver
AVCA6_RS07025	COG4999	Histidine kinase
AVCA6_RS07025	COG2205	protein histidine kinase activity
AVCA6_RS07025	COG3850	Histidine kinase
AVCA6_RS07055	COG1960	acyl-CoA dehydrogenase activity
AVCA6_RS07060	COG1131	(ABC) transporter
AVCA6_RS07065	COG0842	Transport permease protein
AVCA6_RS07080	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AVCA6_RS07080	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AVCA6_RS07085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AVCA6_RS07090	COG0727	PFAM Uncharacterised protein family (UPF0153)
AVCA6_RS07095	COG0778	Nitroreductase
AVCA6_RS07100	COG0642	Histidine kinase
AVCA6_RS07110	COG0745	RESPONSE REGULATOR receiver
AVCA6_RS07115	COG2350	Protein conserved in bacteria
AVCA6_RS07120	COG2917	probably involved in intracellular septation
AVCA6_RS07125	COG0613	PHP domain protein
AVCA6_RS07130	COG0009	L-threonylcarbamoyladenylate synthase
AVCA6_RS07135	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AVCA6_RS07140	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AVCA6_RS07165	COG0800	Aldolase
AVCA6_RS07175	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS07180	COG0546	phosphoglycolate phosphatase activity
AVCA6_RS07185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVCA6_RS07190	COG0402	S-adenosylhomocysteine deaminase activity
AVCA6_RS07195	COG0675	Transposase, IS605 OrfB family
AVCA6_RS07200	COG3415	Transposase
AVCA6_RS07200	COG2801	Transposase and inactivated derivatives
AVCA6_RS07205	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AVCA6_RS07215	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AVCA6_RS07230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AVCA6_RS07235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AVCA6_RS07245	COG0776	regulation of translation
AVCA6_RS07255	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AVCA6_RS07265	COG1088	dTDP-glucose 4,6-dehydratase activity
AVCA6_RS07285	COG1682	transport, permease protein
AVCA6_RS07350	COG1450	Type ii and iii secretion system protein
AVCA6_RS07395	COG1459	type II secretion system
AVCA6_RS07400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AVCA6_RS07425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AVCA6_RS07435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVCA6_RS07445	COG1643	Atp-dependent helicase
AVCA6_RS07450	COG2161	toxin-antitoxin pair type II binding
AVCA6_RS07485	COG2814	Major facilitator Superfamily
AVCA6_RS07495	COG0183	Belongs to the thiolase family
AVCA6_RS07500	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVCA6_RS07500	COG1024	Enoyl-CoA hydratase
AVCA6_RS07505	COG1960	acyl-CoA dehydrogenase activity
AVCA6_RS07525	COG0427	acetyl-CoA hydrolase
AVCA6_RS07530	COG2801	Transposase and inactivated derivatives
AVCA6_RS07555	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS07580	COG2801	Transposase and inactivated derivatives
AVCA6_RS07595	COG1063	alcohol dehydrogenase
AVCA6_RS07615	COG0166	Belongs to the GPI family
AVCA6_RS07625	COG4580	involved in the transport of maltose and maltodextrins
AVCA6_RS07640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVCA6_RS07645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVCA6_RS07650	COG0427	acetyl-CoA hydrolase
AVCA6_RS07655	COG0583	DNA-binding transcription factor activity
AVCA6_RS07660	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS07670	COG0842	Transport permease protein
AVCA6_RS07675	COG0842	Transport permease protein
AVCA6_RS07675	COG1129	ABC transporter
AVCA6_RS07680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVCA6_RS07685	COG0675	Transposase, IS605 OrfB family
AVCA6_RS07690	COG0167	dihydroorotate dehydrogenase activity
AVCA6_RS07695	COG3321	synthase
AVCA6_RS07695	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS07695	COG0604	alcohol dehydrogenase
AVCA6_RS07715	COG4221	oxidoreductase activity
AVCA6_RS07725	COG2133	pyrroloquinoline quinone binding
AVCA6_RS07810	COG0583	DNA-binding transcription factor activity
AVCA6_RS07825	COG2851	Citrate transporter
AVCA6_RS07860	COG1857	crispr-associated protein
AVCA6_RS07880	COG4680	protein conserved in bacteria
AVCA6_RS07900	COG0438	transferase activity, transferring glycosyl groups
AVCA6_RS07905	COG2814	Major facilitator Superfamily
AVCA6_RS07920	COG2197	response regulator
AVCA6_RS07925	COG4585	Histidine kinase
AVCA6_RS07930	COG1024	Enoyl-CoA hydratase
AVCA6_RS07930	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVCA6_RS07935	COG0183	Belongs to the thiolase family
AVCA6_RS07940	COG0318	PFAM AMP-dependent synthetase and ligase
AVCA6_RS07945	COG1960	acyl-CoA dehydrogenase activity
AVCA6_RS07965	COG0003	Pfam Anion-transporting ATPase
AVCA6_RS07975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AVCA6_RS08000	COG3639	organic phosphonate transmembrane transporter activity
AVCA6_RS08005	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AVCA6_RS08020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVCA6_RS08025	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AVCA6_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS08040	COG2610	gluconate transmembrane transporter activity
AVCA6_RS08045	COG3604	Transcriptional regulator
AVCA6_RS08065	COG0166	Belongs to the GPI family
AVCA6_RS08070	COG0738	Major facilitator superfamily
AVCA6_RS08105	COG2814	Major facilitator Superfamily
AVCA6_RS08115	COG0583	DNA-binding transcription factor activity
AVCA6_RS08120	COG3642	lipopolysaccharide core region biosynthetic process
AVCA6_RS08130	COG3850	Histidine kinase
AVCA6_RS08130	COG5002	protein histidine kinase activity
AVCA6_RS08145	COG4067	protein conserved in archaea
AVCA6_RS08145	COG0189	ligase activity
AVCA6_RS08160	COG0574	Belongs to the PEP-utilizing enzyme family
AVCA6_RS08160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVCA6_RS08170	COG3002	Belongs to the UPF0753 family
AVCA6_RS08205	COG1278	Cold shock
AVCA6_RS08225	COG1403	HNH endonuclease
AVCA6_RS08230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AVCA6_RS08235	COG4191	Histidine kinase
AVCA6_RS08245	COG0477	Major facilitator Superfamily
AVCA6_RS08260	COG3416	Protein conserved in bacteria
AVCA6_RS08265	COG2824	Alkylphosphonate utilization operon protein PhnA
AVCA6_RS08300	COG0217	transcriptional regulatory protein
AVCA6_RS08325	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AVCA6_RS08330	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AVCA6_RS08345	COG0826	peptidase U32
AVCA6_RS08400	COG1902	pentaerythritol trinitrate reductase activity
AVCA6_RS08410	COG1309	transcriptional regulator
AVCA6_RS08415	COG0604	alcohol dehydrogenase
AVCA6_RS08495	COG0642	Histidine kinase
AVCA6_RS08505	COG2900	Belongs to the SlyX family
AVCA6_RS08510	COG0747	negative chemotaxis
AVCA6_RS08515	COG0601	transmembrane transport
AVCA6_RS08520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVCA6_RS08530	COG3139	Protein of unknown function (DUF1315)
AVCA6_RS08540	COG0308	aminopeptidase N
AVCA6_RS08545	COG0427	acetyl-CoA hydrolase
AVCA6_RS08550	COG3344	reverse transcriptase
AVCA6_RS08585	COG0714	Associated with various cellular activities
AVCA6_RS08595	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AVCA6_RS08595	COG0392	lysyltransferase activity
AVCA6_RS08620	COG0167	dihydroorotate dehydrogenase activity
AVCA6_RS08625	COG3130	regulation of translation
AVCA6_RS08630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AVCA6_RS08630	COG0116	Belongs to the methyltransferase superfamily
AVCA6_RS08635	COG2027	D-alanyl-D-alanine carboxypeptidase
AVCA6_RS08670	COG1525	nuclease
AVCA6_RS08710	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AVCA6_RS08715	COG0513	Belongs to the DEAD box helicase family
AVCA6_RS08720	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AVCA6_RS08725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AVCA6_RS08730	COG5265	(ABC) transporter
AVCA6_RS08735	COG0583	DNA-binding transcription factor activity
AVCA6_RS08780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AVCA6_RS08790	COG4659	FMN binding
AVCA6_RS08795	COG4658	electron transport chain
AVCA6_RS08805	COG2878	Part of a membrane complex involved in electron transport
AVCA6_RS08810	COG4657	Part of a membrane complex involved in electron transport
AVCA6_RS08815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVCA6_RS08815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVCA6_RS08820	COG0489	protein tyrosine kinase activity
AVCA6_RS08825	COG0717	Belongs to the dCTP deaminase family
AVCA6_RS08870	COG3012	SEC-C Motif Domain Protein
AVCA6_RS08890	COG1199	ATP-dependent helicase activity
AVCA6_RS08910	COG0259	pyridoxamine-phosphate oxidase activity
AVCA6_RS08920	COG3133	Outer membrane lipoprotein
AVCA6_RS08925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AVCA6_RS08925	COG2111	Na H antiporter
AVCA6_RS08930	COG1006	Multisubunit Na H antiporter MnhC subunit
AVCA6_RS08935	COG0651	ATP synthesis coupled electron transport
AVCA6_RS08940	COG1863	multisubunit Na H antiporter MnhE subunit
AVCA6_RS08945	COG2212	antiporter activity
AVCA6_RS08950	COG1320	monovalent cation:proton antiporter activity
AVCA6_RS08995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AVCA6_RS09000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AVCA6_RS09015	COG0356	it plays a direct role in the translocation of protons across the membrane
AVCA6_RS09025	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AVCA6_RS09025	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AVCA6_RS09030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AVCA6_RS09040	COG3639	organic phosphonate transmembrane transporter activity
AVCA6_RS09045	COG3639	organic phosphonate transmembrane transporter activity
AVCA6_RS09055	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AVCA6_RS09065	COG3622	Belongs to the hyi family
AVCA6_RS09070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AVCA6_RS09075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AVCA6_RS09080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AVCA6_RS09095	COG1294	oxidase, subunit
AVCA6_RS09110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVCA6_RS09140	COG0348	domain, Protein
AVCA6_RS09145	COG2010	Cytochrome c
AVCA6_RS09160	COG3278	Belongs to the heme-copper respiratory oxidase family
AVCA6_RS09180	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AVCA6_RS09210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVCA6_RS09215	COG0668	transmembrane transport
AVCA6_RS09220	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AVCA6_RS09230	COG0564	pseudouridine synthase activity
AVCA6_RS09235	COG0071	Belongs to the small heat shock protein (HSP20) family
AVCA6_RS09250	COG1414	Transcriptional regulator
AVCA6_RS09255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVCA6_RS09260	COG1053	succinate dehydrogenase
AVCA6_RS09270	COG1053	succinate dehydrogenase
AVCA6_RS09290	COG1063	alcohol dehydrogenase
AVCA6_RS09310	COG1053	succinate dehydrogenase
AVCA6_RS09330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVCA6_RS09350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AVCA6_RS09360	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AVCA6_RS09365	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AVCA6_RS09370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AVCA6_RS09375	COG0072	phenylalanine-tRNA ligase activity
AVCA6_RS09380	COG0776	regulation of translation
AVCA6_RS09420	COG2801	Transposase and inactivated derivatives
AVCA6_RS09430	COG2853	Lipoprotein
AVCA6_RS09435	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AVCA6_RS09440	COG0142	geranyltranstransferase activity
AVCA6_RS09445	COG1722	exodeoxyribonuclease VII activity
AVCA6_RS09455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AVCA6_RS09460	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AVCA6_RS09500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVCA6_RS09515	COG1657	PFAM Prenyltransferase squalene oxidase
AVCA6_RS09535	COG0583	DNA-binding transcription factor activity
AVCA6_RS09545	COG1902	pentaerythritol trinitrate reductase activity
AVCA6_RS09550	COG2814	Major facilitator Superfamily
AVCA6_RS09560	COG4396	Host-nuclease inhibitor protein Gam
AVCA6_RS09575	COG0145	ligase activity
AVCA6_RS09580	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AVCA6_RS09585	COG4647	ligase activity
AVCA6_RS09590	COG3284	Transcriptional regulator
AVCA6_RS09605	COG1045	serine acetyltransferase
AVCA6_RS09610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVCA6_RS09615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVCA6_RS09625	COG3415	Transposase
AVCA6_RS09625	COG2801	Transposase and inactivated derivatives
AVCA6_RS09635	COG1024	Enoyl-CoA hydratase
AVCA6_RS09650	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AVCA6_RS09655	COG4266	Belongs to the allantoicase family
AVCA6_RS09685	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS09690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVCA6_RS09695	COG1535	isochorismatase
AVCA6_RS09695	COG3433	isochorismatase activity
AVCA6_RS09700	COG1021	2,3-dihydroxybenzoate-AMP ligase
AVCA6_RS09705	COG1169	isochorismate synthase
AVCA6_RS09720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AVCA6_RS09745	COG3842	ATPase activity
AVCA6_RS09755	COG1053	succinate dehydrogenase
AVCA6_RS09765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA6_RS09780	COG0583	DNA-binding transcription factor activity
AVCA6_RS09790	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AVCA6_RS09795	COG0277	FAD linked oxidase domain protein
AVCA6_RS09800	COG0436	Aminotransferase
AVCA6_RS09805	COG0765	amino acid transport
AVCA6_RS09810	COG0765	amino acid transport
AVCA6_RS09815	COG1126	abc transporter atp-binding protein
AVCA6_RS09825	COG0625	glutathione transferase activity
AVCA6_RS09845	COG3712	iron ion homeostasis
AVCA6_RS09850	COG1595	DNA-templated transcription, initiation
AVCA6_RS09860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVCA6_RS09865	COG0235	Class ii aldolase
AVCA6_RS09870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVCA6_RS09875	COG1116	anion transmembrane transporter activity
AVCA6_RS09880	COG4206	TonB-dependent receptor
AVCA6_RS09890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA6_RS09895	COG0583	DNA-binding transcription factor activity
AVCA6_RS09915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA6_RS09920	COG0667	Aldo Keto reductase
AVCA6_RS09925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA6_RS09945	COG4771	TonB-dependent receptor
AVCA6_RS09950	COG1609	Transcriptional regulator
AVCA6_RS09955	COG5642	Protein of unknown function (DUF2384)
AVCA6_RS09960	COG5654	RES domain protein
AVCA6_RS09980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA6_RS09990	COG2175	clavaminate synthase activity
AVCA6_RS10000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA6_RS10005	COG1902	pentaerythritol trinitrate reductase activity
AVCA6_RS10020	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AVCA6_RS10030	COG0596	Alpha beta hydrolase
AVCA6_RS10035	COG2175	clavaminate synthase activity
AVCA6_RS10055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVCA6_RS10065	COG1063	alcohol dehydrogenase
AVCA6_RS10080	COG2376	Dihydroxyacetone kinase
AVCA6_RS10085	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS10090	COG1879	ABC-type sugar transport system periplasmic component
AVCA6_RS10095	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVCA6_RS10100	COG1129	ABC transporter
AVCA6_RS10105	COG0698	ribose 5-phosphate isomerase
AVCA6_RS10110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVCA6_RS10120	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AVCA6_RS10140	COG0148	phosphopyruvate hydratase activity
AVCA6_RS10145	COG4566	intracellular signal transduction
AVCA6_RS10155	COG0318	PFAM AMP-dependent synthetase and ligase
AVCA6_RS10160	COG0402	S-adenosylhomocysteine deaminase activity
AVCA6_RS10170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVCA6_RS10180	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AVCA6_RS10185	COG3415	Transposase
AVCA6_RS10185	COG2801	Transposase and inactivated derivatives
AVCA6_RS10205	COG0667	Aldo Keto reductase
AVCA6_RS10210	COG0625	glutathione transferase activity
AVCA6_RS10215	COG2175	clavaminate synthase activity
AVCA6_RS10220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA6_RS10250	COG3265	gluconokinase activity
AVCA6_RS10265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVCA6_RS10270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVCA6_RS10275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA6_RS10275	COG1116	anion transmembrane transporter activity
AVCA6_RS10300	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AVCA6_RS10305	COG0625	glutathione transferase activity
AVCA6_RS10310	COG4774	siderophore transport
AVCA6_RS10315	COG3712	iron ion homeostasis
AVCA6_RS10320	COG1595	DNA-templated transcription, initiation
AVCA6_RS10350	COG2217	Heavy metal translocating P-type atpase
AVCA6_RS10375	COG0783	Belongs to the Dps family
AVCA6_RS10410	COG3204	pilus organization
AVCA6_RS10430	COG3409	Peptidoglycan-binding domain 1 protein
AVCA6_RS10430	COG3267	Type II secretory pathway component ExeA
AVCA6_RS10475	COG0084	hydrolase, TatD family'
AVCA6_RS10480	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AVCA6_RS10495	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AVCA6_RS10500	COG4181	ATPase activity
AVCA6_RS10550	COG0189	ligase activity
AVCA6_RS10565	COG1802	Transcriptional regulator
AVCA6_RS10590	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AVCA6_RS10600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AVCA6_RS10610	COG0668	transmembrane transport
AVCA6_RS10630	COG0243	molybdopterin cofactor binding
AVCA6_RS10635	COG2146	nitrite reductase [NAD(P)H] activity
AVCA6_RS10640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AVCA6_RS10645	COG0515	serine threonine protein kinase
AVCA6_RS10645	COG2815	serine threonine protein kinase
AVCA6_RS10650	COG2223	nitrite transmembrane transporter activity
AVCA6_RS10670	COG0436	Aminotransferase
AVCA6_RS10685	COG1116	anion transmembrane transporter activity
AVCA6_RS10685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA6_RS10705	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVCA6_RS10715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVCA6_RS10720	COG0215	cysteine-tRNA ligase activity
AVCA6_RS10725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AVCA6_RS10745	COG0544	peptidyl-prolyl cis-trans isomerase activity
AVCA6_RS10755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AVCA6_RS10760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AVCA6_RS10775	COG3243	poly(R)-hydroxyalkanoic acid synthase
AVCA6_RS10785	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS10800	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AVCA6_RS10805	COG0302	gtp cyclohydrolase
AVCA6_RS10820	COG1335	isochorismatase
AVCA6_RS10835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AVCA6_RS10845	COG0235	Class ii aldolase
AVCA6_RS10855	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AVCA6_RS10865	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AVCA6_RS10885	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AVCA6_RS10925	COG3293	Transposase
AVCA6_RS10950	COG1815	bacterial-type flagellum-dependent cell motility
AVCA6_RS10955	COG1558	bacterial-type flagellum-dependent cell motility
AVCA6_RS10960	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AVCA6_RS10970	COG4787	bacterial-type flagellum-dependent cell motility
AVCA6_RS10980	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AVCA6_RS10985	COG1706	bacterial-type flagellum-dependent cell motility
AVCA6_RS10990	COG1705	Flagellar rod assembly protein muramidase FlgJ
AVCA6_RS10990	COG3951	Flagellar rod assembly protein muramidase FlgJ
AVCA6_RS11030	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AVCA6_RS11065	COG1766	The M ring may be actively involved in energy transduction
AVCA6_RS11070	COG1677	Flagellar hook-basal body complex protein FliE
AVCA6_RS11095	COG2257	FlhB HrpN YscU SpaS Family
AVCA6_RS11115	COG1360	Flagellar Motor Protein
AVCA6_RS11120	COG2198	Histidine kinase
AVCA6_RS11120	COG0643	Histidine kinase
AVCA6_RS11125	COG0835	chemotaxis
AVCA6_RS11130	COG0840	transmembrane signaling receptor activity
AVCA6_RS11135	COG0840	transmembrane signaling receptor activity
AVCA6_RS11140	COG0840	transmembrane signaling receptor activity
AVCA6_RS11155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVCA6_RS11165	COG0747	negative chemotaxis
AVCA6_RS11195	COG2205	protein histidine kinase activity
AVCA6_RS11200	COG0745	RESPONSE REGULATOR receiver
AVCA6_RS11205	COG3158	transport of potassium into the cell
AVCA6_RS11230	COG3344	reverse transcriptase
AVCA6_RS11265	COG2814	Major facilitator Superfamily
AVCA6_RS11285	COG3344	reverse transcriptase
AVCA6_RS11300	COG0604	alcohol dehydrogenase
AVCA6_RS11310	COG0392	lysyltransferase activity
AVCA6_RS11315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AVCA6_RS11320	COG3568	Endonuclease Exonuclease Phosphatase
AVCA6_RS11355	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AVCA6_RS11360	COG0297	glycogen (starch) synthase activity
AVCA6_RS11365	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVCA6_RS11370	COG1960	acyl-CoA dehydrogenase activity
AVCA6_RS11375	COG0477	Major facilitator Superfamily
AVCA6_RS11380	COG0583	DNA-binding transcription factor activity
AVCA6_RS11385	COG0659	secondary active sulfate transmembrane transporter activity
AVCA6_RS11425	COG0322	excinuclease ABC activity
AVCA6_RS11445	COG1309	transcriptional regulator
AVCA6_RS11500	COG0784	Response regulator, receiver
AVCA6_RS11500	COG2198	Histidine kinase
AVCA6_RS11500	COG2205	protein histidine kinase activity
AVCA6_RS11510	COG2199	diguanylate cyclase activity
AVCA6_RS11510	COG2202	Pas domain
AVCA6_RS11510	COG2200	EAL domain
AVCA6_RS11530	COG1960	acyl-CoA dehydrogenase activity
AVCA6_RS11535	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVCA6_RS11540	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVCA6_RS11550	COG0318	PFAM AMP-dependent synthetase and ligase
AVCA6_RS11555	COG4191	Histidine kinase
AVCA6_RS11590	COG4566	intracellular signal transduction
AVCA6_RS11595	COG1309	transcriptional regulator
AVCA6_RS11600	COG1752	Esterase of the alpha-beta hydrolase superfamily
AVCA6_RS11735	COG0069	glutamate synthase activity
AVCA6_RS11770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVCA6_RS11770	COG0543	2 iron, 2 sulfur cluster binding
AVCA6_RS11775	COG0071	Belongs to the small heat shock protein (HSP20) family
AVCA6_RS11780	COG0459	protein refolding
AVCA6_RS11785	COG0589	response to stress
AVCA6_RS11800	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AVCA6_RS11805	COG2010	Cytochrome c
AVCA6_RS11805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVCA6_RS11815	COG0667	Aldo Keto reductase
AVCA6_RS11820	COG0583	DNA-binding transcription factor activity
AVCA6_RS11825	COG1368	sulfuric ester hydrolase activity
AVCA6_RS11830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AVCA6_RS11835	COG1742	UPF0060 membrane protein
AVCA6_RS11840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AVCA6_RS11845	COG0640	Transcriptional regulator
AVCA6_RS11865	COG2271	Major facilitator Superfamily
AVCA6_RS11870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVCA6_RS11875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVCA6_RS11890	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVCA6_RS11890	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVCA6_RS11895	COG1760	l-serine dehydratase
AVCA6_RS11900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AVCA6_RS11950	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AVCA6_RS11955	COG1609	Transcriptional regulator
AVCA6_RS11960	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS11990	COG5642	Protein of unknown function (DUF2384)
AVCA6_RS12000	COG2986	histidine ammonia-lyase
AVCA6_RS12005	COG0402	S-adenosylhomocysteine deaminase activity
AVCA6_RS12055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVCA6_RS12060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVCA6_RS12065	COG1120	ATPase activity
AVCA6_RS12080	COG2267	carboxylic ester hydrolase activity
AVCA6_RS12185	COG0515	serine threonine protein kinase
AVCA6_RS12245	COG0477	Major facilitator Superfamily
AVCA6_RS12250	COG0579	oxidoreductase
AVCA6_RS12260	COG0579	oxidoreductase
AVCA6_RS12265	COG2186	Transcriptional regulator
AVCA6_RS12270	COG1609	Transcriptional regulator
AVCA6_RS12280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVCA6_RS12300	COG4580	involved in the transport of maltose and maltodextrins
AVCA6_RS12335	COG0483	inositol monophosphate 1-phosphatase activity
AVCA6_RS12340	COG0612	Peptidase, M16
AVCA6_RS12360	COG1611	Belongs to the LOG family
AVCA6_RS12370	COG2814	Major facilitator Superfamily
AVCA6_RS12395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AVCA6_RS12400	COG4580	involved in the transport of maltose and maltodextrins
AVCA6_RS12410	COG0148	phosphopyruvate hydratase activity
AVCA6_RS12420	COG0800	Aldolase
AVCA6_RS12430	COG1737	Transcriptional regulator
AVCA6_RS12440	COG1609	Transcriptional regulator
AVCA6_RS12445	COG3265	gluconokinase activity
AVCA6_RS12450	COG1070	Carbohydrate kinase
AVCA6_RS12455	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AVCA6_RS12465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVCA6_RS12480	COG0395	ABC-type sugar transport system, permease component
AVCA6_RS12485	COG1175	transmembrane transport
AVCA6_RS12495	COG4977	sequence-specific DNA binding
AVCA6_RS12495	COG1917	Cupin 2, conserved barrel domain protein
AVCA6_RS12500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AVCA6_RS12505	COG2706	6-phosphogluconolactonase activity
AVCA6_RS12525	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AVCA6_RS12545	COG3344	reverse transcriptase
AVCA6_RS12550	COG0616	signal peptide processing
AVCA6_RS12565	COG2816	NAD+ diphosphatase activity
AVCA6_RS12630	COG1215	transferase activity, transferring glycosyl groups
AVCA6_RS12660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AVCA6_RS12685	COG1334	flagellar protein FlaG
AVCA6_RS12690	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AVCA6_RS12695	COG1191	sigma factor activity
AVCA6_RS12720	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AVCA6_RS12725	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AVCA6_RS12730	COG0745	RESPONSE REGULATOR receiver
AVCA6_RS12735	COG0840	transmembrane signaling receptor activity
AVCA6_RS12740	COG0840	transmembrane signaling receptor activity
AVCA6_RS12745	COG2201	protein-glutamate methylesterase activity
AVCA6_RS12750	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AVCA6_RS12755	COG0366	Alpha amylase catalytic
AVCA6_RS12765	COG1944	ATP diphosphatase activity
AVCA6_RS12770	COG2081	HI0933 family
AVCA6_RS12830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AVCA6_RS12835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AVCA6_RS12835	COG1648	precorrin-2 dehydrogenase activity
AVCA6_RS12840	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AVCA6_RS12845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AVCA6_RS12850	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AVCA6_RS12855	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AVCA6_RS12865	COG0492	ferredoxin-NADP+ reductase activity
AVCA6_RS12870	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AVCA6_RS12875	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AVCA6_RS12880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AVCA6_RS12885	COG0542	response to heat
AVCA6_RS12890	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AVCA6_RS12895	COG1278	Cold shock
AVCA6_RS12920	COG0482	sulfurtransferase activity
AVCA6_RS12925	COG2915	High frequency lysogenization protein hflD homolog
AVCA6_RS12935	COG2850	peptidyl-arginine hydroxylation
AVCA6_RS12960	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVCA6_RS12965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVCA6_RS12970	COG0649	NAD binding
AVCA6_RS12970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVCA6_RS12990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AVCA6_RS12995	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVCA6_RS13005	COG0713	ATP synthesis coupled electron transport
AVCA6_RS13020	COG1007	ATP synthesis coupled electron transport
AVCA6_RS13035	COG3212	peptidase
AVCA6_RS13040	COG0720	synthase
AVCA6_RS13045	COG0741	lytic transglycosylase activity
AVCA6_RS13055	COG1459	type II secretion system
AVCA6_RS13070	COG2135	peptidase activity
AVCA6_RS13080	COG0488	(ABC) transporter
AVCA6_RS13085	COG1968	undecaprenyl-diphosphatase activity
AVCA6_RS13095	COG0316	Belongs to the HesB IscA family
AVCA6_RS13095	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AVCA6_RS13105	COG1538	Outer membrane efflux protein
AVCA6_RS13130	COG1115	amino acid carrier protein
AVCA6_RS13135	COG2911	Protein conserved in bacteria
AVCA6_RS13140	COG0729	surface antigen
AVCA6_RS13170	COG0300	oxidoreductase activity
AVCA6_RS13185	COG0300	oxidoreductase activity
AVCA6_RS13195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVCA6_RS13210	COG4191	Histidine kinase
AVCA6_RS13220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AVCA6_RS13225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AVCA6_RS13280	COG0745	RESPONSE REGULATOR receiver
AVCA6_RS13295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AVCA6_RS13305	COG1469	GTP cyclohydrolase I activity
AVCA6_RS13330	COG1653	transport
AVCA6_RS13335	COG5002	protein histidine kinase activity
AVCA6_RS13335	COG0784	Response regulator, receiver
AVCA6_RS13335	COG2205	protein histidine kinase activity
AVCA6_RS13345	COG0322	excinuclease ABC activity
AVCA6_RS13350	COG4702	Belongs to the UPF0303 family
AVCA6_RS13365	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AVCA6_RS13390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVCA6_RS13395	COG1116	anion transmembrane transporter activity
AVCA6_RS13400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA6_RS13410	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AVCA6_RS13430	COG0577	efflux transmembrane transporter activity
AVCA6_RS13470	COG0328	RNA-DNA hybrid ribonuclease activity
AVCA6_RS13485	COG1388	LysM domain
AVCA6_RS13485	COG0741	lytic transglycosylase activity
AVCA6_RS13495	COG4166	transmembrane transport
AVCA6_RS13500	COG4174	ABC transporter (Permease)
AVCA6_RS13505	COG4239	(ABC) transporter, permease
AVCA6_RS13510	COG4172	Belongs to the ABC transporter superfamily
AVCA6_RS13520	COG2233	PERMEase
AVCA6_RS13540	COG0045	succinate-CoA ligase (ADP-forming) activity
AVCA6_RS13565	COG1053	succinate dehydrogenase
AVCA6_RS13570	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AVCA6_RS13575	COG2009	succinate dehydrogenase
AVCA6_RS13600	COG3123	guanosine phosphorylase activity
AVCA6_RS13610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVCA6_RS13625	COG3206	protein involved in exopolysaccharide biosynthesis
AVCA6_RS13625	COG0489	protein tyrosine kinase activity
AVCA6_RS13630	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AVCA6_RS13635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVCA6_RS13640	COG1132	(ABC) transporter
AVCA6_RS13645	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AVCA6_RS13660	COG0463	Glycosyl transferase, family 2
AVCA6_RS13670	COG0438	transferase activity, transferring glycosyl groups
AVCA6_RS13675	COG0438	transferase activity, transferring glycosyl groups
AVCA6_RS13680	COG0438	transferase activity, transferring glycosyl groups
AVCA6_RS13695	COG0438	transferase activity, transferring glycosyl groups
AVCA6_RS13700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AVCA6_RS13710	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AVCA6_RS13725	COG1216	Glycosyl transferase, family 2
AVCA6_RS13730	COG1442	glycosyl transferase family 8
AVCA6_RS13730	COG1216	Glycosyl transferase, family 2
AVCA6_RS13740	COG0318	PFAM AMP-dependent synthetase and ligase
AVCA6_RS13745	COG2030	dehydratase
AVCA6_RS13750	COG0402	S-adenosylhomocysteine deaminase activity
AVCA6_RS13765	COG0673	inositol 2-dehydrogenase activity
AVCA6_RS13785	COG1053	succinate dehydrogenase
AVCA6_RS13795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AVCA6_RS13800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AVCA6_RS13805	COG3115	cell septum assembly
AVCA6_RS13810	COG1196	nuclear chromosome segregation
AVCA6_RS13815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AVCA6_RS13850	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AVCA6_RS13905	COG1116	anion transmembrane transporter activity
AVCA6_RS13910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVCA6_RS13915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA6_RS13920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA6_RS13925	COG0431	NADPH-dependent FMN reductase
AVCA6_RS13930	COG0450	alkyl hydroperoxide reductase
AVCA6_RS13935	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AVCA6_RS13950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVCA6_RS13955	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AVCA6_RS13985	COG3550	peptidyl-serine autophosphorylation
AVCA6_RS14005	COG0798	PFAM Bile acid sodium symporter
AVCA6_RS14020	COG2871	sodium ion transport
AVCA6_RS14090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVCA6_RS14100	COG4221	oxidoreductase activity
AVCA6_RS14105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVCA6_RS14110	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AVCA6_RS14120	COG2175	clavaminate synthase activity
AVCA6_RS14130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVCA6_RS14150	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS14190	COG1960	acyl-CoA dehydrogenase activity
AVCA6_RS14205	COG1116	anion transmembrane transporter activity
AVCA6_RS14210	COG2205	protein histidine kinase activity
AVCA6_RS14215	COG0745	RESPONSE REGULATOR receiver
AVCA6_RS14230	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AVCA6_RS14240	COG1301	dicarboxylic acid transport
AVCA6_RS14245	COG0583	DNA-binding transcription factor activity
AVCA6_RS14260	COG3384	dioxygenase
AVCA6_RS14265	COG0583	DNA-binding transcription factor activity
AVCA6_RS14270	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AVCA6_RS14275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AVCA6_RS14280	COG2828	Protein conserved in bacteria
AVCA6_RS14295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA6_RS14315	COG0235	Class ii aldolase
AVCA6_RS14320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA6_RS14330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA6_RS14340	COG0673	inositol 2-dehydrogenase activity
AVCA6_RS14350	COG1335	isochorismatase
AVCA6_RS14380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AVCA6_RS14385	COG2011	ABC-type metal ion transport system permease component
AVCA6_RS14400	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AVCA6_RS14405	COG1518	maintenance of DNA repeat elements
AVCA6_RS14445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA6_RS14465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AVCA6_RS14470	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AVCA6_RS14475	COG4208	sulfate ABC transporter
AVCA6_RS14485	COG3781	membrane
AVCA6_RS14525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AVCA6_RS14535	COG4118	positive regulation of growth
AVCA6_RS14550	COG4680	protein conserved in bacteria
AVCA6_RS14580	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
AVCA6_RS14620	COG3385	transposase activity
AVCA6_RS14650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVCA6_RS14655	COG1960	acyl-CoA dehydrogenase activity
AVCA6_RS14660	COG3039	Transposase
AVCA6_RS14685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA6_RS14705	COG1073	alpha beta
AVCA6_RS14720	COG2814	Major facilitator Superfamily
AVCA6_RS14725	COG1064	alcohol dehydrogenase
AVCA6_RS14750	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS14755	COG2207	Transcriptional regulator
AVCA6_RS14770	COG0667	Aldo Keto reductase
AVCA6_RS14780	COG0300	oxidoreductase activity
AVCA6_RS14785	COG0667	Aldo Keto reductase
AVCA6_RS14795	COG0667	Aldo Keto reductase
AVCA6_RS14835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AVCA6_RS14840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AVCA6_RS14850	COG0745	RESPONSE REGULATOR receiver
AVCA6_RS14855	COG2853	Lipoprotein
AVCA6_RS14890	COG0514	ATP-dependent DNA helicase (RecQ)
AVCA6_RS14900	COG2832	Protein of unknown function (DUF454)
AVCA6_RS14910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AVCA6_RS14925	COG0121	glutamine amidotransferase
AVCA6_RS14940	COG1295	ribonuclease BN
AVCA6_RS14950	COG2983	Belongs to the UPF0260 family
AVCA6_RS14960	COG3100	YcgL domain-containing protein
AVCA6_RS14990	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AVCA6_RS14995	COG0406	alpha-ribazole phosphatase activity
AVCA6_RS15000	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AVCA6_RS15010	COG1492	cobalamin metabolic process
AVCA6_RS15020	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AVCA6_RS15025	COG0778	Nitroreductase
AVCA6_RS15030	COG1797	cobyrinic acid a,c-diamide synthase activity
AVCA6_RS15045	COG4206	TonB-dependent receptor
AVCA6_RS15050	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AVCA6_RS15055	COG0505	Belongs to the CarA family
AVCA6_RS15060	COG0791	NLP P60 protein
AVCA6_RS15065	COG0791	NLP P60 protein
AVCA6_RS15080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AVCA6_RS15085	COG0037	tRNA processing
AVCA6_RS15095	COG3091	SprT-like family
AVCA6_RS15115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AVCA6_RS15115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AVCA6_RS15120	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AVCA6_RS15130	COG3293	Transposase
AVCA6_RS15145	COG1943	Transposase
AVCA6_RS15150	COG2226	methyltransferase
AVCA6_RS15195	COG0861	Integral membrane protein TerC family
AVCA6_RS15230	COG2801	Transposase and inactivated derivatives
AVCA6_RS15230	COG3415	Transposase
AVCA6_RS15255	COG4580	involved in the transport of maltose and maltodextrins
AVCA6_RS15275	COG1609	Transcriptional regulator
AVCA6_RS15285	COG0477	Major facilitator Superfamily
AVCA6_RS15285	COG2814	Major facilitator Superfamily
AVCA6_RS15290	COG1082	Xylose isomerase domain protein TIM barrel
AVCA6_RS15315	COG0583	DNA-binding transcription factor activity
AVCA6_RS15325	COG2031	fatty acid transporter
AVCA6_RS15330	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVCA6_RS15340	COG1785	Belongs to the alkaline phosphatase family
AVCA6_RS15350	COG0604	alcohol dehydrogenase
AVCA6_RS15375	COG2084	Dehydrogenase
AVCA6_RS15390	COG1609	Transcriptional regulator
AVCA6_RS15430	COG0705	Rhomboid family
AVCA6_RS15435	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AVCA6_RS15440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AVCA6_RS15490	COG1286	toxin biosynthetic process
AVCA6_RS15500	COG0285	dihydrofolate synthase activity
AVCA6_RS15505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AVCA6_RS15510	COG0135	phosphoribosylanthranilate isomerase activity
AVCA6_RS15535	COG0473	3-isopropylmalate dehydrogenase activity
AVCA6_RS15545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AVCA6_RS15565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AVCA6_RS15575	COG0800	Aldolase
AVCA6_RS15585	COG0745	RESPONSE REGULATOR receiver
AVCA6_RS15620	COG2239	Acts as a magnesium transporter
AVCA6_RS15645	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AVCA6_RS15655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AVCA6_RS15675	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVCA6_RS15685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVCA6_RS15695	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AVCA6_RS15700	COG2301	Belongs to the HpcH HpaI aldolase family
AVCA6_RS15735	COG2154	pterin-4-alpha-carbinolamine dehydratase
AVCA6_RS15815	COG0271	Belongs to the BolA IbaG family
AVCA6_RS15825	COG0114	fumarate hydratase activity
AVCA6_RS15850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVCA6_RS15850	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AVCA6_RS15855	COG1846	Transcriptional regulator
AVCA6_RS15860	COG0367	asparagine synthase
AVCA6_RS15865	COG0189	ligase activity
AVCA6_RS15865	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVCA6_RS15870	COG1363	Peptidase, m42
AVCA6_RS15880	COG3089	Belongs to the UPF0270 family
AVCA6_RS15890	COG1253	flavin adenine dinucleotide binding
AVCA6_RS15895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVCA6_RS15900	COG3162	membrane
AVCA6_RS15925	COG2853	Lipoprotein
AVCA6_RS15930	COG1560	Kdo2-lipid A biosynthetic process
AVCA6_RS15935	COG0850	regulation of cytokinetic process
AVCA6_RS15940	COG2894	cell division
AVCA6_RS15945	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AVCA6_RS15950	COG0564	pseudouridine synthase activity
AVCA6_RS15955	COG1362	aminopeptidase activity
AVCA6_RS15960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVCA6_RS15960	COG0604	alcohol dehydrogenase
AVCA6_RS15960	COG4221	oxidoreductase activity
AVCA6_RS15960	COG3321	synthase
AVCA6_RS15980	COG3339	Conserved Protein
AVCA6_RS15985	COG0545	Peptidyl-prolyl cis-trans isomerase
AVCA6_RS16005	COG2205	protein histidine kinase activity
AVCA6_RS16010	COG3174	membrane
AVCA6_RS16050	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AVCA6_RS16055	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AVCA6_RS16060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVCA6_RS16070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AVCA6_RS16075	COG0425	Belongs to the sulfur carrier protein TusA family
AVCA6_RS16080	COG4783	chaperone-mediated protein folding
AVCA6_RS16085	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AVCA6_RS16095	COG0471	metal ion transport
AVCA6_RS16110	COG1064	alcohol dehydrogenase
AVCA6_RS16135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AVCA6_RS16195	COG3846	protein secretion by the type IV secretion system
AVCA6_RS16210	COG3451	type IV secretory pathway VirB4
AVCA6_RS16220	COG3838	Conjugal transfer protein Trbc
AVCA6_RS16225	COG4962	Type ii secretion system protein e
AVCA6_RS16245	COG0583	DNA-binding transcription factor activity
AVCA6_RS16270	COG1309	transcriptional regulator
AVCA6_RS16275	COG2249	NAD(P)H dehydrogenase (quinone) activity
AVCA6_RS16290	COG0583	DNA-binding transcription factor activity
AVCA6_RS16295	COG2814	Major facilitator Superfamily
AVCA6_RS16310	COG0583	DNA-binding transcription factor activity
AVCA6_RS16315	COG2814	Major facilitator Superfamily
AVCA6_RS16330	COG4959	Type IV secretory pathway protease TraF
AVCA6_RS16375	COG2003	Belongs to the UPF0758 family
AVCA6_RS16410	COG3657	addiction module killer protein
AVCA6_RS16430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVCA6_RS16440	COG3293	Transposase
AVCA6_RS16520	COG2963	transposase activity
AVCA6_RS16605	COG2801	Transposase and inactivated derivatives
AVCA6_RS16650	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AVCA6_RS16660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AVCA6_RS16665	COG0602	queuosine metabolic process
AVCA6_RS16670	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AVCA6_RS16700	COG0824	Thioesterase
AVCA6_RS16705	COG2255	four-way junction helicase activity
AVCA6_RS16715	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AVCA6_RS16725	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AVCA6_RS16735	COG0442	prolyl-tRNA aminoacylation
AVCA6_RS16755	COG1295	ribonuclease BN
AVCA6_RS16775	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AVCA6_RS16780	COG0628	permease
AVCA6_RS16795	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AVCA6_RS16800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AVCA6_RS16810	COG3077	Addiction module antitoxin, RelB DinJ family
AVCA6_RS16820	COG3122	Protein conserved in bacteria
AVCA6_RS16825	COG3956	TIGRFAM MazG family protein
AVCA6_RS16845	COG2819	hydrolase of the alpha beta superfamily
AVCA6_RS16850	COG0500	methyltransferase
AVCA6_RS16875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AVCA6_RS16880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AVCA6_RS16890	COG5002	protein histidine kinase activity
AVCA6_RS16890	COG2205	protein histidine kinase activity
AVCA6_RS16890	COG0784	Response regulator, receiver
AVCA6_RS16895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AVCA6_RS16950	COG3561	AntA/AntB antirepressor
AVCA6_RS17130	COG4695	Portal protein
AVCA6_RS17140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AVCA6_RS17155	COG2308	Evidence 4 Homologs of previously reported genes of
AVCA6_RS17160	COG0693	protein deglycase activity
AVCA6_RS17165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AVCA6_RS17195	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AVCA6_RS17205	COG1902	pentaerythritol trinitrate reductase activity
AVCA6_RS17220	COG5001	Diguanylate cyclase
AVCA6_RS17220	COG3300	MHYT domain
AVCA6_RS17245	COG2831	hemolysin activation secretion protein
AVCA6_RS17265	COG0583	DNA-binding transcription factor activity
AVCA6_RS17270	COG0604	alcohol dehydrogenase
AVCA6_RS17270	COG3321	synthase
AVCA6_RS17270	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS17285	COG2814	Major facilitator Superfamily
AVCA6_RS17300	COG0667	Aldo Keto reductase
AVCA6_RS17305	COG0667	Aldo Keto reductase
AVCA6_RS17320	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AVCA6_RS17325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVCA6_RS17330	COG1309	transcriptional regulator
AVCA6_RS17335	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AVCA6_RS17335	COG1082	Xylose isomerase domain protein TIM barrel
AVCA6_RS17350	COG0656	L-ascorbic acid biosynthetic process
AVCA6_RS17360	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVCA6_RS17365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVCA6_RS17380	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AVCA6_RS17385	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AVCA6_RS17390	COG1414	Transcriptional regulator
AVCA6_RS17395	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AVCA6_RS17400	COG3485	protocatechuate 3,4-dioxygenase
AVCA6_RS17405	COG3485	protocatechuate 3,4-dioxygenase
AVCA6_RS17410	COG0583	DNA-binding transcription factor activity
AVCA6_RS17415	COG0788	formyltetrahydrofolate deformylase activity
AVCA6_RS17425	COG2925	Exonuclease
AVCA6_RS17450	COG0714	Associated with various cellular activities
AVCA6_RS17465	COG0589	response to stress
AVCA6_RS17475	COG3706	GGDEF domain
AVCA6_RS17480	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AVCA6_RS17480	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AVCA6_RS17500	COG0583	DNA-binding transcription factor activity
AVCA6_RS17510	COG3148	PFAM DTW domain containing protein
AVCA6_RS17520	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AVCA6_RS17525	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AVCA6_RS17535	COG2137	regulation of response to DNA damage stimulus
AVCA6_RS17540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AVCA6_RS17545	COG1546	Belongs to the CinA family
AVCA6_RS17580	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AVCA6_RS17590	COG0840	transmembrane signaling receptor activity
AVCA6_RS17595	COG0840	transmembrane signaling receptor activity
AVCA6_RS17610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AVCA6_RS17615	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AVCA6_RS17620	COG0585	pseudouridine synthase activity
AVCA6_RS17625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AVCA6_RS17630	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AVCA6_RS17635	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AVCA6_RS17640	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AVCA6_RS17655	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AVCA6_RS17660	COG0504	CTP synthase activity
AVCA6_RS17670	COG0825	malonyl-CoA metabolic process
AVCA6_RS17680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AVCA6_RS17685	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVCA6_RS17690	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVCA6_RS17695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AVCA6_RS17720	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AVCA6_RS17730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AVCA6_RS17735	COG0233	cytoplasmic translational termination
AVCA6_RS17740	COG0528	UMP kinase activity
AVCA6_RS17745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AVCA6_RS17750	COG0052	Belongs to the universal ribosomal protein uS2 family
AVCA6_RS17755	COG0024	Methionine aminopeptidase
AVCA6_RS17760	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AVCA6_RS17765	COG0436	Aminotransferase
AVCA6_RS17770	COG0025	NhaP-type Na H and K H
AVCA6_RS17795	COG1393	Belongs to the ArsC family
AVCA6_RS17800	COG2171	N-acyltransferase activity
AVCA6_RS17820	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AVCA6_RS17835	COG2226	methyltransferase
AVCA6_RS17860	COG1131	(ABC) transporter
AVCA6_RS17870	COG0742	ribosomal rna small subunit methyltransferase
AVCA6_RS17880	COG1801	Protein of unknown function DUF72
AVCA6_RS17885	COG1214	PFAM Peptidase M22, glycoprotease
AVCA6_RS17890	COG0563	adenylate kinase activity
AVCA6_RS17895	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AVCA6_RS17915	COG1073	alpha beta
AVCA6_RS17940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AVCA6_RS17945	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AVCA6_RS17955	COG1902	pentaerythritol trinitrate reductase activity
AVCA6_RS18000	COG1607	acyl-coa hydrolase
AVCA6_RS18005	COG0335	large ribosomal subunit rRNA binding
AVCA6_RS18010	COG0336	Belongs to the RNA methyltransferase TrmD family
AVCA6_RS18015	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AVCA6_RS18020	COG0228	four-way junction DNA binding
AVCA6_RS18025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AVCA6_RS18035	COG4536	flavin adenine dinucleotide binding
AVCA6_RS18040	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AVCA6_RS18045	COG0494	nUDIX hydrolase
AVCA6_RS18055	COG1388	LysM domain
AVCA6_RS18055	COG1376	ErfK ybiS ycfS ynhG family protein
AVCA6_RS18070	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AVCA6_RS18080	COG2132	Multicopper oxidase
AVCA6_RS18105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVCA6_RS18115	COG1570	exodeoxyribonuclease VII activity
AVCA6_RS18125	COG0739	heme binding
AVCA6_RS18175	COG0583	DNA-binding transcription factor activity
AVCA6_RS18180	COG0402	S-adenosylhomocysteine deaminase activity
AVCA6_RS18200	COG0477	Major facilitator Superfamily
AVCA6_RS18210	COG2909	trisaccharide binding
AVCA6_RS18215	COG0371	Dehydrogenase
AVCA6_RS18225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVCA6_RS18235	COG4993	Dehydrogenase
AVCA6_RS18245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVCA6_RS18260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVCA6_RS18265	COG2356	endonuclease I
AVCA6_RS18270	COG3647	Membrane
AVCA6_RS18285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVCA6_RS18290	COG0436	Aminotransferase
AVCA6_RS18310	COG1160	GTP binding
AVCA6_RS18320	COG2976	Protein conserved in bacteria
AVCA6_RS18325	COG0124	histidyl-tRNA synthetase
AVCA6_RS18330	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AVCA6_RS18350	COG0105	UTP biosynthetic process
AVCA6_RS18365	COG0443	Heat shock 70 kDa protein
AVCA6_RS18370	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AVCA6_RS18375	COG0316	Belongs to the HesB IscA family
AVCA6_RS18385	COG1104	cysteine desulfurase activity
AVCA6_RS18420	COG1862	Preprotein translocase
AVCA6_RS18425	COG0343	queuine tRNA-ribosyltransferase activity
AVCA6_RS18430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AVCA6_RS18440	COG0582	viral genome integration into host DNA
AVCA6_RS18445	COG2801	Transposase and inactivated derivatives
AVCA6_RS18485	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AVCA6_RS18490	COG3657	addiction module killer protein
AVCA6_RS18535	COG0268	Binds directly to 16S ribosomal RNA
AVCA6_RS18545	COG3045	CreA protein
AVCA6_RS18550	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AVCA6_RS18555	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AVCA6_RS18560	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AVCA6_RS18565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AVCA6_RS18570	COG0142	geranyltranstransferase activity
AVCA6_RS18575	COG0545	Peptidyl-prolyl cis-trans isomerase
AVCA6_RS18580	COG2862	Uncharacterized protein family, UPF0114
AVCA6_RS18590	COG1067	ATP-dependent peptidase activity
AVCA6_RS18630	COG1595	DNA-templated transcription, initiation
AVCA6_RS18635	COG0488	(ABC) transporter
AVCA6_RS18640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AVCA6_RS18645	COG0523	cobalamin synthesis protein
AVCA6_RS18650	COG2879	small protein
AVCA6_RS18655	COG1966	Carbon starvation protein
AVCA6_RS18670	COG2020	methyltransferase activity
AVCA6_RS18685	COG1970	mechanosensitive ion channel activity
AVCA6_RS18690	COG0386	Belongs to the glutathione peroxidase family
AVCA6_RS18700	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AVCA6_RS18715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVCA6_RS18730	COG1525	nuclease
AVCA6_RS18735	COG2198	Histidine kinase
AVCA6_RS18735	COG0784	Response regulator, receiver
AVCA6_RS18735	COG2205	protein histidine kinase activity
AVCA6_RS18745	COG2989	Protein conserved in bacteria
AVCA6_RS18755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVCA6_RS18760	COG2813	Specifically methylates the guanine in position
AVCA6_RS18765	COG2119	membrane
AVCA6_RS18770	COG2119	membrane
AVCA6_RS18775	COG0501	Belongs to the peptidase M48B family
AVCA6_RS18780	COG2135	peptidase activity
AVCA6_RS18815	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AVCA6_RS18820	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AVCA6_RS18825	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVCA6_RS18830	COG1090	epimerase
AVCA6_RS18835	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AVCA6_RS18845	COG0789	Transcriptional regulator
AVCA6_RS18850	COG0415	Belongs to the DNA photolyase family
AVCA6_RS18855	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AVCA6_RS18860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AVCA6_RS18870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AVCA6_RS18875	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AVCA6_RS18890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AVCA6_RS18905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AVCA6_RS18910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AVCA6_RS18915	COG0193	aminoacyl-tRNA hydrolase activity
AVCA6_RS18950	COG1025	Belongs to the peptidase M16 family
AVCA6_RS18960	COG0535	radical SAM domain protein
AVCA6_RS18970	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AVCA6_RS18975	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AVCA6_RS18980	COG3284	Transcriptional regulator
AVCA6_RS18985	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS18990	COG3199	ATP-NAD kinase
AVCA6_RS18995	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AVCA6_RS19000	COG0022	dehydrogenase e1 component
AVCA6_RS19010	COG1063	alcohol dehydrogenase
AVCA6_RS19025	COG1509	lysine 2,3-aminomutase activity
AVCA6_RS19035	COG2801	Transposase and inactivated derivatives
AVCA6_RS19055	COG2814	Major facilitator Superfamily
AVCA6_RS19075	COG0659	secondary active sulfate transmembrane transporter activity
AVCA6_RS19080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVCA6_RS19100	COG3093	addiction module antidote protein HigA
AVCA6_RS19115	COG0583	DNA-binding transcription factor activity
AVCA6_RS19120	COG3135	benzoate transporter
AVCA6_RS19130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVCA6_RS19130	COG0543	2 iron, 2 sulfur cluster binding
AVCA6_RS19135	COG2814	Major facilitator Superfamily
AVCA6_RS19140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVCA6_RS19145	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AVCA6_RS19155	COG3971	2-oxopent-4-enoate hydratase activity
AVCA6_RS19185	COG3384	dioxygenase
AVCA6_RS19235	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AVCA6_RS19245	COG1335	isochorismatase
AVCA6_RS19255	COG0675	Transposase, IS605 OrfB family
AVCA6_RS19265	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AVCA6_RS19290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVCA6_RS19295	COG3008	intermembrane lipid transfer
AVCA6_RS19300	COG2995	paraquat-inducible protein a
AVCA6_RS19305	COG2995	paraquat-inducible protein a
AVCA6_RS19335	COG1183	phosphatidylcholine synthase activity
AVCA6_RS19340	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AVCA6_RS19350	COG0028	Belongs to the TPP enzyme family
AVCA6_RS19360	COG3098	single-species biofilm formation
AVCA6_RS19370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AVCA6_RS19390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVCA6_RS19400	COG1489	DNA binding
AVCA6_RS19405	COG0436	Aminotransferase
AVCA6_RS19410	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AVCA6_RS19415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVCA6_RS19425	COG3852	Histidine kinase
AVCA6_RS19435	COG0617	tRNA 3'-terminal CCA addition
AVCA6_RS19450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AVCA6_RS19455	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AVCA6_RS19460	COG0166	Belongs to the GPI family
AVCA6_RS19480	COG1185	polyribonucleotide nucleotidyltransferase activity
AVCA6_RS19485	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AVCA6_RS19495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AVCA6_RS19500	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AVCA6_RS19505	COG0195	Participates in both transcription termination and antitermination
AVCA6_RS19510	COG0779	Required for maturation of 30S ribosomal subunits
AVCA6_RS19525	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AVCA6_RS19530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AVCA6_RS19535	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AVCA6_RS19540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVCA6_RS19545	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AVCA6_RS19570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AVCA6_RS19575	COG0484	heat shock protein binding
AVCA6_RS19580	COG0443	Heat shock 70 kDa protein
AVCA6_RS19585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AVCA6_RS19590	COG0497	DNA recombination
AVCA6_RS19600	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVCA6_RS19605	COG2914	Belongs to the UPF0125 (RnfH) family
AVCA6_RS19615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AVCA6_RS19620	COG2186	Transcriptional regulator
AVCA6_RS19625	COG1620	l-lactate permease
AVCA6_RS19630	COG0247	lactate metabolic process
AVCA6_RS19635	COG1139	Iron-sulfur cluster binding protein
AVCA6_RS19650	COG2205	protein histidine kinase activity
AVCA6_RS19685	COG0528	UMP kinase activity
AVCA6_RS19690	COG0528	UMP kinase activity
AVCA6_RS19695	COG3960	tartronate-semialdehyde synthase activity
AVCA6_RS19700	COG0583	DNA-binding transcription factor activity
AVCA6_RS19705	COG0281	malic enzyme
AVCA6_RS19710	COG1620	l-lactate permease
AVCA6_RS19715	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AVCA6_RS19720	COG3193	protein, possibly involved in utilization of glycolate and propanediol
AVCA6_RS19725	COG0247	lactate metabolic process
AVCA6_RS19730	COG0277	FAD linked oxidase domain protein
AVCA6_RS19735	COG0277	FAD linked oxidase domain protein
AVCA6_RS19740	COG2186	Transcriptional regulator
AVCA6_RS19745	COG0148	phosphopyruvate hydratase activity
AVCA6_RS19755	COG3835	regulator
AVCA6_RS19760	COG1929	Belongs to the glycerate kinase type-1 family
AVCA6_RS19765	COG3960	tartronate-semialdehyde synthase activity
AVCA6_RS19770	COG3622	Belongs to the hyi family
AVCA6_RS19775	COG2084	Dehydrogenase
AVCA6_RS19780	COG1741	Belongs to the pirin family
AVCA6_RS19805	COG3150	esterase
AVCA6_RS19810	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AVCA6_RS19820	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVCA6_RS19860	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVCA6_RS19865	COG1129	ABC transporter
AVCA6_RS19880	COG1960	acyl-CoA dehydrogenase activity
AVCA6_RS19890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVCA6_RS19900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVCA6_RS19900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVCA6_RS19965	COG0626	cystathionine gamma-synthase activity
AVCA6_RS19975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA6_RS19985	COG3829	transcription factor binding
AVCA6_RS20000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA6_RS20010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVCA6_RS20055	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AVCA6_RS20070	COG2995	paraquat-inducible protein a
AVCA6_RS20075	COG2995	paraquat-inducible protein a
AVCA6_RS20080	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AVCA6_RS20080	COG3008	intermembrane lipid transfer
AVCA6_RS20085	COG2963	transposase activity
AVCA6_RS20105	COG1595	DNA-templated transcription, initiation
AVCA6_RS20115	COG0628	permease
AVCA6_RS20145	COG1132	(ABC) transporter
AVCA6_RS20150	COG0156	8-amino-7-oxononanoate synthase activity
AVCA6_RS20155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVCA6_RS20170	COG0456	acetyltransferase
AVCA6_RS20180	COG1213	nucleotidyl transferase
AVCA6_RS20195	COG1183	phosphatidylcholine synthase activity
AVCA6_RS20245	COG1216	Glycosyl transferase, family 2
AVCA6_RS20245	COG0463	Glycosyl transferase, family 2
AVCA6_RS20265	COG0583	DNA-binding transcription factor activity
AVCA6_RS20280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVCA6_RS20300	COG0494	nUDIX hydrolase
AVCA6_RS20310	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AVCA6_RS20315	COG1519	Transferase
AVCA6_RS20325	COG0667	Aldo Keto reductase
AVCA6_RS20350	COG2755	lipolytic protein G-D-S-L family
AVCA6_RS20350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AVCA6_RS20355	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AVCA6_RS20355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AVCA6_RS20370	COG1132	(ABC) transporter
AVCA6_RS20385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AVCA6_RS20390	COG1442	glycosyl transferase family 8
AVCA6_RS20405	COG0438	transferase activity, transferring glycosyl groups
AVCA6_RS20410	COG2192	nodulation
AVCA6_RS20430	COG0438	transferase activity, transferring glycosyl groups
AVCA6_RS20435	COG0859	PFAM glycosyl transferase family 9
AVCA6_RS20440	COG0859	PFAM glycosyl transferase family 9
AVCA6_RS20475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVCA6_RS20495	COG2026	Addiction module toxin, RelE StbE family
AVCA6_RS20515	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AVCA6_RS20520	COG0583	DNA-binding transcription factor activity
AVCA6_RS20530	COG1942	4-Oxalocrotonate Tautomerase
AVCA6_RS20535	COG3263	regulation of cellular component size
AVCA6_RS20540	COG3264	Mechanosensitive ion channel
AVCA6_RS20540	COG1196	nuclear chromosome segregation
AVCA6_RS20545	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AVCA6_RS20555	COG0730	response to heat
AVCA6_RS20560	COG3118	belongs to the thioredoxin family
AVCA6_RS20570	COG1192	Involved in chromosome partitioning
AVCA6_RS20575	COG0583	DNA-binding transcription factor activity
AVCA6_RS20580	COG2814	Major facilitator Superfamily
AVCA6_RS20585	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AVCA6_RS20590	COG0493	'glutamate synthase
AVCA6_RS20595	COG0070	glutamate synthase
AVCA6_RS20595	COG0069	glutamate synthase activity
AVCA6_RS20595	COG0067	glutamate synthase
AVCA6_RS20605	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AVCA6_RS20610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AVCA6_RS20650	COG0281	malic enzyme
AVCA6_RS20655	COG0254	rRNA binding
AVCA6_RS20660	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AVCA6_RS20665	COG0018	arginyl-trna synthetase
AVCA6_RS20675	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AVCA6_RS20680	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AVCA6_RS20690	COG2226	methyltransferase
AVCA6_RS20700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AVCA6_RS20705	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AVCA6_RS20710	COG0140	phosphoribosyl-ATP diphosphatase activity
AVCA6_RS20715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVCA6_RS20720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVCA6_RS20760	COG1490	D-aminoacyl-tRNA deacylase activity
AVCA6_RS20775	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AVCA6_RS20800	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AVCA6_RS20805	COG0058	SHG alpha-glucan phosphorylase activity
AVCA6_RS20835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AVCA6_RS20855	COG0148	phosphopyruvate hydratase activity
AVCA6_RS20860	COG0149	triose-phosphate isomerase activity
AVCA6_RS20885	COG3344	reverse transcriptase
AVCA6_RS20890	COG1217	gtp-binding protein TYPA
AVCA6_RS20895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVCA6_RS20895	COG0301	tRNA thio-modification
AVCA6_RS20915	COG3852	Histidine kinase
AVCA6_RS20925	COG0450	alkyl hydroperoxide reductase
AVCA6_RS20930	COG1960	acyl-CoA dehydrogenase activity
AVCA6_RS20940	COG0778	Nitroreductase
AVCA6_RS20945	COG0716	FMN binding
AVCA6_RS20980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AVCA6_RS20985	COG0739	heme binding
AVCA6_RS20990	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AVCA6_RS20995	COG3344	reverse transcriptase
AVCA6_RS21000	COG0316	Belongs to the HesB IscA family
AVCA6_RS21005	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AVCA6_RS21010	COG1981	membrane
AVCA6_RS21015	COG0537	adenosine 5'-monophosphoramidase activity
AVCA6_RS21020	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AVCA6_RS21025	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AVCA6_RS21030	COG1765	OsmC-like protein
AVCA6_RS21040	COG0134	indole-3-glycerol-phosphate synthase activity
AVCA6_RS21045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AVCA6_RS21050	COG0512	Glutamine amidotransferase of anthranilate synthase
AVCA6_RS21060	COG0586	Pfam SNARE associated Golgi protein
AVCA6_RS21070	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVCA6_RS21070	COG0022	dehydrogenase e1 component
AVCA6_RS21075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AVCA6_RS21085	COG0789	Transcriptional regulator
AVCA6_RS21100	COG1335	isochorismatase
AVCA6_RS21115	COG2249	NAD(P)H dehydrogenase (quinone) activity
AVCA6_RS21125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AVCA6_RS21125	COG2169	Transcriptional regulator
AVCA6_RS21140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVCA6_RS21150	COG1404	Belongs to the peptidase S8 family
AVCA6_RS21150	COG4935	Belongs to the peptidase S8 family
AVCA6_RS21165	COG0477	Major facilitator Superfamily
AVCA6_RS21175	COG1538	Outer membrane efflux protein
AVCA6_RS21185	COG0384	phenazine biosynthesis protein PhzF
AVCA6_RS21195	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AVCA6_RS21210	COG0583	DNA-binding transcription factor activity
AVCA6_RS21285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AVCA6_RS21290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AVCA6_RS21295	COG0583	DNA-binding transcription factor activity
AVCA6_RS21305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVCA6_RS21310	COG0477	Major facilitator Superfamily
AVCA6_RS21325	COG1028	Short-chain dehydrogenase reductase Sdr
AVCA6_RS21330	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AVCA6_RS21335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AVCA6_RS21345	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AVCA6_RS21365	COG2967	ApaG domain
AVCA6_RS21370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AVCA6_RS21375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVCA6_RS21380	COG2766	serine protein kinase
AVCA6_RS21385	COG2718	Belongs to the UPF0229 family
AVCA6_RS21390	COG2719	SpoVR family
AVCA6_RS21395	COG0617	tRNA 3'-terminal CCA addition
AVCA6_RS21410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVCA6_RS21420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AVCA6_RS21425	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AVCA6_RS21430	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AVCA6_RS21440	COG0358	DNA primase activity
AVCA6_RS21445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AVCA6_RS21450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVCA6_RS21470	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AVCA6_RS21485	COG1546	Belongs to the CinA family
AVCA6_RS21485	COG1058	Belongs to the CinA family
AVCA6_RS21490	COG3546	catalase activity
AVCA6_RS21525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVCA6_RS21530	COG1120	ATPase activity
AVCA6_RS21535	COG1595	DNA-templated transcription, initiation
AVCA6_RS21540	COG3712	iron ion homeostasis
AVCA6_RS21545	COG4772	TonB-dependent receptor
AVCA6_RS21555	COG2267	carboxylic ester hydrolase activity
AVCA6_RS21580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVCA6_RS21580	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVCA6_RS21595	COG1178	ABC-type Fe3 transport system permease component
AVCA6_RS21605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVCA6_RS21610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVCA6_RS21615	COG0006	proline dipeptidase activity
AVCA6_RS21620	COG3079	Belongs to the UPF0149 family
AVCA6_RS21635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AVCA6_RS21650	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AVCA6_RS21665	COG0248	Ppx GppA phosphatase
AVCA6_RS21670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AVCA6_RS21680	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AVCA6_RS21685	COG1671	Belongs to the UPF0178 family
AVCA6_RS21700	COG0861	Integral membrane protein TerC family
AVCA6_RS21705	COG0488	(ABC) transporter
AVCA6_RS21755	COG0165	Argininosuccinate lyase
AVCA6_RS21775	COG1965	Belongs to the frataxin family
AVCA6_RS21790	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AVCA6_RS21800	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AVCA6_RS21820	COG0432	Pfam Uncharacterised protein family UPF0047
AVCA6_RS21825	COG0004	ammonium transporteR
AVCA6_RS21830	COG0347	Belongs to the P(II) protein family
AVCA6_RS21835	COG2960	long-chain fatty acid transporting porin activity
AVCA6_RS21840	COG0606	chelatase, subunit chli
AVCA6_RS21850	COG0583	DNA-binding transcription factor activity
AVCA6_RS21860	COG1741	Belongs to the pirin family
AVCA6_RS21895	COG0753	catalase activity
AVCA6_RS21900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AVCA6_RS21925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVCA6_RS21935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVCA6_RS21945	COG1012	belongs to the aldehyde dehydrogenase family
AVCA6_RS21950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AVCA6_RS21955	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AVCA6_RS21960	COG0747	negative chemotaxis
AVCA6_RS21970	COG2177	Part of the ABC transporter FtsEX involved in
AVCA6_RS21975	COG2884	Cell division ATP-binding protein ftsE
AVCA6_RS21980	COG0552	protein localization to endoplasmic reticulum
AVCA6_RS21990	COG0584	glycerophosphoryl diester phosphodiesterase
AVCA6_RS22000	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AVCA6_RS22005	COG0697	spore germination
AVCA6_RS22010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVCA6_RS22015	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AVCA6_RS22020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AVCA6_RS22025	COG0730	response to heat
AVCA6_RS22040	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
AVCA6_RS22045	COG0494	nUDIX hydrolase
AVCA6_RS22060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AVCA6_RS22065	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AVCA6_RS22075	COG0179	Fumarylacetoacetate (FAA) hydrolase
AVCA6_RS22080	COG0277	FAD linked oxidase domain protein
AVCA6_RS22085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVCA6_RS22090	COG0679	Auxin Efflux Carrier
AVCA6_RS22095	COG3180	Ammonia monooxygenase
AVCA6_RS22130	COG0583	DNA-binding transcription factor activity
AVCA6_RS22135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AVCA6_RS22165	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AVCA6_RS22180	COG1253	flavin adenine dinucleotide binding
AVCA6_RS22185	COG0739	heme binding
AVCA6_RS22200	COG0581	inorganic phosphate transmembrane transporter activity
AVCA6_RS22205	COG0573	inorganic phosphate transmembrane transporter activity
AVCA6_RS22215	COG1607	acyl-coa hydrolase
AVCA6_RS22220	COG0676	glucose-6-phosphate 1-epimerase activity
AVCA6_RS22255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVCA6_RS22275	COG1177	transmembrane transport
AVCA6_RS22280	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVCA6_RS22285	COG3842	ATPase activity
AVCA6_RS22300	COG3547	Transposase (IS116 IS110 IS902 family)
AVCA6_RS22305	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AVCA6_RS22315	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
AVCA6_RS22325	COG0174	glutamine synthetase
AVCA6_RS22330	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AVCA6_RS22335	COG0174	glutamine synthetase
AVCA6_RS22345	COG2957	Belongs to the agmatine deiminase family
AVCA6_RS22350	COG0640	Transcriptional regulator
AVCA6_RS22360	COG3706	GGDEF domain
AVCA6_RS22430	COG3909	cytochrome
AVCA6_RS22445	COG0667	Aldo Keto reductase
AVCA6_RS22475	COG0596	Alpha beta hydrolase
AVCA6_RS22515	COG1012	belongs to the aldehyde dehydrogenase family
AVCA6_RS22530	COG0165	Argininosuccinate lyase
AVCA6_RS22535	COG1301	dicarboxylic acid transport
AVCA6_RS22540	COG0583	DNA-binding transcription factor activity
AVCA6_RS22610	COG3180	Ammonia monooxygenase
AVCA6_RS22625	COG1024	Enoyl-CoA hydratase
AVCA6_RS22630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AVCA6_RS22635	COG1960	acyl-CoA dehydrogenase activity
AVCA6_RS22640	COG0789	Transcriptional regulator
AVCA6_RS22650	COG2851	Citrate transporter
AVCA6_RS22655	COG0861	Integral membrane protein TerC family
AVCA6_RS22785	COG3293	Transposase
AVCA6_RS22800	COG0679	Auxin Efflux Carrier
AVCA6_RS22805	COG0149	triose-phosphate isomerase activity
AVCA6_RS22820	COG0697	spore germination
AVCA6_RS22830	COG0149	triose-phosphate isomerase activity
AVCA6_RS22835	COG0148	phosphopyruvate hydratase activity
AVCA6_RS22860	COG3718	enzyme involved in inositol metabolism
AVCA6_RS22865	COG2814	Major facilitator Superfamily
AVCA6_RS22865	COG0477	Major facilitator Superfamily
AVCA6_RS22880	COG3962	Belongs to the TPP enzyme family
AVCA6_RS22885	COG0673	inositol 2-dehydrogenase activity
AVCA6_RS22890	COG1082	Xylose isomerase domain protein TIM barrel
AVCA6_RS22895	COG1879	ABC-type sugar transport system periplasmic component
AVCA6_RS22930	COG0625	glutathione transferase activity
AVCA6_RS22940	COG1609	Transcriptional regulator
AVCA6_RS22960	COG0673	inositol 2-dehydrogenase activity
AVCA6_RS22965	COG4580	involved in the transport of maltose and maltodextrins
AVCA6_RS22975	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVCA6_RS22980	COG1129	ABC transporter
AVCA6_RS23080	COG2914	Belongs to the UPF0125 (RnfH) family
AVCA6_RS23085	COG4660	Part of a membrane complex involved in electron transport
AVCA6_RS23100	COG4656	Part of a membrane complex involved in electron transport
AVCA6_RS23105	COG2878	Part of a membrane complex involved in electron transport
AVCA6_RS23110	COG4657	Part of a membrane complex involved in electron transport
AVCA6_RS23150	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AVCA6_RS23160	COG3604	Transcriptional regulator
AVCA6_RS23170	COG1125	glycine betaine transport
AVCA6_RS23170	COG0517	IMP dehydrogenase activity
AVCA6_RS23175	COG2116	formate transmembrane transporter activity
AVCA6_RS23180	COG2271	Major facilitator Superfamily
AVCA6_RS23230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVCA6_RS23240	COG2271	Major facilitator Superfamily
AVCA6_RS23245	COG4948	Mandelate Racemase Muconate Lactonizing
AVCA6_RS23250	COG0800	Aldolase
AVCA6_RS23260	COG1414	Transcriptional regulator
AVCA6_RS23270	COG4580	involved in the transport of maltose and maltodextrins
AVCA6_RS23275	COG2207	Transcriptional regulator
AVCA6_RS23285	COG1486	melibiose metabolic process
AVCA6_RS23290	COG2211	Major facilitator Superfamily
AVCA6_RS23300	COG3386	PFAM SMP-30 Gluconolaconase
AVCA6_RS23310	COG0366	Alpha amylase catalytic
AVCA6_RS23315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AVCA6_RS23330	COG0667	Aldo Keto reductase
AVCA6_RS23345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVCA6_RS23350	COG1538	Outer membrane efflux protein
AVCA6_RS23355	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVCA6_RS23370	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AVCA6_RS23400	COG0840	transmembrane signaling receptor activity
AVCA6_RS23410	COG2852	Protein conserved in bacteria
AVCA6_RS23415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AVCA6_RS23420	COG1074	ATP-dependent DNA helicase activity
AVCA6_RS23425	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AVCA6_RS23440	COG1272	protein, Hemolysin III
AVCA6_RS23445	COG1082	Xylose isomerase domain protein TIM barrel
AVCA6_RS23490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AVCA6_RS23495	COG1349	DNA-binding transcription factor activity
AVCA6_RS23505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AVCA6_RS23520	COG0601	transmembrane transport
AVCA6_RS23525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVCA6_RS23530	COG4172	Belongs to the ABC transporter superfamily
AVCA6_RS23550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AVCA6_RS23590	COG4771	TonB-dependent receptor
AVCA6_RS23605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AVCA6_RS23610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AVCA6_RS23615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AVCA6_RS23620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AVCA6_RS23625	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AVCA6_RS23630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AVCA6_RS23640	COG0356	it plays a direct role in the translocation of protons across the membrane
AVCA6_RS23645	COG3312	ion transport
AVCA6_RS23650	COG1475	DNA binding
AVCA6_RS23655	COG1192	Involved in chromosome partitioning
AVCA6_RS23660	COG0357	Ribosomal RNA small subunit methyltransferase G
AVCA6_RS23665	COG0445	tRNA wobble uridine modification
AVCA6_RS23695	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AVCA6_RS23715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AVCA6_RS23740	COG0706	membrane insertase activity
AVCA6_RS23745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AVCA6_RS23750	COG0594	ribonuclease P activity
AVCA6_RS23755	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AVCA6_RS23785	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AVCA6_RS23865	COG0583	DNA-binding transcription factor activity