locus-tag	class	description
I4W80_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I4W80_RS00010	COG0592	DNA-directed DNA polymerase activity
I4W80_RS00015	COG2501	S4 domain
I4W80_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I4W80_RS00030	COG0187	DNA topoisomerase II activity
I4W80_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I4W80_RS00070	COG0516	GMP reductase activity
I4W80_RS00070	COG0517	IMP dehydrogenase activity
I4W80_RS00075	COG1686	Belongs to the peptidase S11 family
I4W80_RS00080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I4W80_RS00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I4W80_RS00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I4W80_RS00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I4W80_RS00100	COG0840	transmembrane signaling receptor activity
I4W80_RS00110	COG1428	Deoxynucleoside kinase
I4W80_RS00115	COG1428	Deoxynucleoside kinase
I4W80_RS00120	COG1388	LysM domain
I4W80_RS00120	COG3858	chitin binding
I4W80_RS00125	COG1335	isochorismatase
I4W80_RS00130	COG0590	tRNA wobble adenosine to inosine editing
I4W80_RS00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I4W80_RS00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I4W80_RS00150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I4W80_RS00195	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I4W80_RS00200	COG3853	Toxic anion resistance protein (TelA)
I4W80_RS00205	COG1982	Orn Lys Arg decarboxylase major
I4W80_RS00210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I4W80_RS00215	COG3870	Protein conserved in bacteria
I4W80_RS00220	COG1728	Protein conserved in bacteria
I4W80_RS00225	COG0470	DNA polymerase III
I4W80_RS00230	COG1774	PSP1 C-terminal conserved region
I4W80_RS00235	COG4467	Involved in initiation control of chromosome replication
I4W80_RS00240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I4W80_RS00245	COG2827	Endonuclease containing a URI domain
I4W80_RS00250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I4W80_RS00255	COG2002	toxin-antitoxin pair type II binding
I4W80_RS00260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4W80_RS00260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4W80_RS00265	COG0084	hydrolase, TatD family'
I4W80_RS00270	COG3584	3D domain protein
I4W80_RS00270	COG3583	domain protein
I4W80_RS00275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I4W80_RS00280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I4W80_RS00290	COG4466	Protein conserved in bacteria
I4W80_RS00300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I4W80_RS00305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I4W80_RS00310	COG0251	oxidation-reduction process
I4W80_RS00315	COG2088	sporulation resulting in formation of a cellular spore
I4W80_RS00325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I4W80_RS00330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I4W80_RS00335	COG0193	aminoacyl-tRNA hydrolase activity
I4W80_RS00345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I4W80_RS00350	COG2002	toxin-antitoxin pair type II binding
I4W80_RS00355	COG2244	polysaccharide biosynthetic process
I4W80_RS00360	COG3956	TIGRFAM MazG family protein
I4W80_RS00365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I4W80_RS00380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I4W80_RS00385	COG1098	S1 RNA binding domain
I4W80_RS00400	COG2208	phosphoserine phosphatase activity
I4W80_RS00405	COG2304	oxidoreductase activity
I4W80_RS00410	COG0515	serine threonine protein kinase
I4W80_RS00415	COG0037	tRNA processing
I4W80_RS00420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I4W80_RS00425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I4W80_RS00430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I4W80_RS00435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I4W80_RS00440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I4W80_RS00445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I4W80_RS00450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I4W80_RS00455	COG0512	Glutamine amidotransferase of anthranilate synthase
I4W80_RS00460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I4W80_RS00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I4W80_RS00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I4W80_RS00475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I4W80_RS00480	COG1396	sequence-specific DNA binding
I4W80_RS00485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I4W80_RS00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I4W80_RS00570	COG4463	regulation of RNA biosynthetic process
I4W80_RS00575	COG3880	PFAM UvrB UvrC protein
I4W80_RS00580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I4W80_RS00585	COG0542	response to heat
I4W80_RS00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I4W80_RS00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I4W80_RS00600	COG4956	integral membrane protein (PIN domain superfamily)
I4W80_RS00605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I4W80_RS00610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I4W80_RS00615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I4W80_RS00620	COG1045	serine acetyltransferase
I4W80_RS00625	COG0215	cysteine-tRNA ligase activity
I4W80_RS00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I4W80_RS00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I4W80_RS00640	COG3688	RNA-binding protein containing a PIN domain
I4W80_RS00645	COG1595	DNA-templated transcription, initiation
I4W80_RS00650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I4W80_RS00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I4W80_RS00660	COG0250	Participates in transcription elongation, termination and antitermination
I4W80_RS00670	COG0081	regulation of translation
I4W80_RS00675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I4W80_RS00680	COG0222	ribosome binding
I4W80_RS00685	COG2813	Specifically methylates the guanine in position
I4W80_RS00690	COG0085	RNA polymerase activity
I4W80_RS00695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I4W80_RS00700	COG1358	cellular component organization or biogenesis
I4W80_RS00705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I4W80_RS00710	COG0049	tRNA binding
I4W80_RS00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I4W80_RS00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I4W80_RS00725	COG0596	Alpha beta hydrolase
I4W80_RS00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I4W80_RS00740	COG0088	Forms part of the polypeptide exit tunnel
I4W80_RS00745	COG0089	rRNA binding
I4W80_RS00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I4W80_RS00755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I4W80_RS00760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I4W80_RS00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I4W80_RS00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I4W80_RS00775	COG0255	Belongs to the universal ribosomal protein uL29 family
I4W80_RS00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I4W80_RS00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I4W80_RS00790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I4W80_RS00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I4W80_RS00800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I4W80_RS00805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I4W80_RS00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I4W80_RS00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I4W80_RS00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I4W80_RS00825	COG1841	ribosomal large subunit assembly
I4W80_RS00830	COG0200	Binds to the 23S rRNA
I4W80_RS00835	COG0201	protein transport
I4W80_RS00840	COG0563	adenylate kinase activity
I4W80_RS00845	COG0024	Methionine aminopeptidase
I4W80_RS00850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I4W80_RS00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I4W80_RS00860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I4W80_RS00865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I4W80_RS00870	COG0202	RNA polymerase activity
I4W80_RS00875	COG0203	ribosomal protein L17
I4W80_RS00880	COG1122	ATPase activity
I4W80_RS00885	COG1122	ATPase activity
I4W80_RS00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I4W80_RS00895	COG0101	tRNA pseudouridine synthase activity
I4W80_RS00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I4W80_RS00905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I4W80_RS00910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I4W80_RS00935	COG0860	N-Acetylmuramoyl-L-alanine amidase
I4W80_RS00940	COG0489	protein tyrosine kinase activity
I4W80_RS00950	COG2194	sulfuric ester hydrolase activity
I4W80_RS00955	COG0726	polysaccharide deacetylase
I4W80_RS00985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I4W80_RS00990	COG0659	secondary active sulfate transmembrane transporter activity
I4W80_RS00995	COG0385	Bile acid
I4W80_RS01000	COG3876	Protein conserved in bacteria
I4W80_RS01005	COG1472	Belongs to the glycosyl hydrolase 3 family
I4W80_RS01010	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I4W80_RS01015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_RS01015	COG1263	PTS System
I4W80_RS01020	COG1737	Transcriptional regulator
I4W80_RS01025	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I4W80_RS01060	COG1595	DNA-templated transcription, initiation
I4W80_RS01065	COG5662	AntiSigma factor
I4W80_RS01070	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I4W80_RS01075	COG4856	YbbR-like protein
I4W80_RS01080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I4W80_RS01085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I4W80_RS01100	COG1131	(ABC) transporter
I4W80_RS01110	COG0577	efflux transmembrane transporter activity
I4W80_RS01110	COG1136	(ABC) transporter
I4W80_RS01120	COG1695	Transcriptional regulator
I4W80_RS01145	COG1131	(ABC) transporter
I4W80_RS01195	COG2311	Membrane
I4W80_RS01215	COG1476	TRANSCRIPTIONal
I4W80_RS01225	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I4W80_RS01230	COG2207	Transcriptional regulator
I4W80_RS01235	COG1309	transcriptional regulator
I4W80_RS01250	COG1113	amino acid transport
I4W80_RS01255	COG0584	glycerophosphoryl diester phosphodiesterase
I4W80_RS01260	COG2271	Major facilitator Superfamily
I4W80_RS01270	COG1331	Highly conserved protein containing a thioredoxin domain
I4W80_RS01280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I4W80_RS01295	COG1131	(ABC) transporter
I4W80_RS01325	COG1937	Protein conserved in bacteria
I4W80_RS01330	COG2210	Belongs to the sulfur carrier protein TusA family
I4W80_RS01340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I4W80_RS01340	COG0425	Belongs to the sulfur carrier protein TusA family
I4W80_RS01345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I4W80_RS01345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I4W80_RS01350	COG0425	Belongs to the sulfur carrier protein TusA family
I4W80_RS01355	COG0730	response to heat
I4W80_RS01370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I4W80_RS01375	COG2814	Major facilitator Superfamily
I4W80_RS01390	COG1846	Transcriptional regulator
I4W80_RS01395	COG1683	Conserved Protein
I4W80_RS01405	COG0656	L-ascorbic acid biosynthetic process
I4W80_RS01410	COG0371	Dehydrogenase
I4W80_RS01415	COG1054	Belongs to the UPF0176 family
I4W80_RS01420	COG0531	amino acid
I4W80_RS01430	COG3711	transcriptional antiterminator
I4W80_RS01435	COG1263	PTS System
I4W80_RS01435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_RS01435	COG2190	(PTS) system
I4W80_RS01440	COG2723	6-phospho-beta-galactosidase activity
I4W80_RS01455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_RS01455	COG3711	transcriptional antiterminator
I4W80_RS01460	COG1940	carbohydrate kinase activity
I4W80_RS01465	COG0383	alpha-mannosidase activity
I4W80_RS01470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4W80_RS01475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4W80_RS01485	COG1404	Belongs to the peptidase S8 family
I4W80_RS01500	COG0833	amino acid
I4W80_RS01505	COG2040	homocysteine
I4W80_RS01510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4W80_RS01515	COG1695	Transcriptional regulator
I4W80_RS01530	COG2814	Major facilitator Superfamily
I4W80_RS01535	COG0456	acetyltransferase
I4W80_RS01550	COG1404	Belongs to the peptidase S8 family
I4W80_RS01560	COG1309	transcriptional regulator
I4W80_RS01565	COG1917	Cupin 2, conserved barrel domain protein
I4W80_RS01570	COG1063	alcohol dehydrogenase
I4W80_RS01575	COG1846	Transcriptional regulator
I4W80_RS01580	COG0318	PFAM AMP-dependent synthetase and ligase
I4W80_RS01585	COG0531	amino acid
I4W80_RS01595	COG0596	Alpha beta hydrolase
I4W80_RS01600	COG1115	amino acid carrier protein
I4W80_RS01605	COG2066	Belongs to the glutaminase family
I4W80_RS01610	COG4191	Histidine kinase
I4W80_RS01615	COG0784	Response regulator, receiver
I4W80_RS01620	COG3012	SEC-C Motif Domain Protein
I4W80_RS01620	COG1405	negative regulation of cell septum assembly
I4W80_RS01630	COG0667	Aldo Keto reductase
I4W80_RS01635	COG3290	protein histidine kinase activity
I4W80_RS01640	COG3279	Response regulator of the LytR AlgR family
I4W80_RS01645	COG4555	ABC transporter
I4W80_RS01650	COG1668	transmembrane transport
I4W80_RS01665	COG3773	Cell wall hydrolase
I4W80_RS01670	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS01680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I4W80_RS01685	COG2310	stress, protein
I4W80_RS01690	COG2310	stress, protein
I4W80_RS01695	COG2310	stress, protein
I4W80_RS01700	COG0861	Integral membrane protein TerC family
I4W80_RS01730	COG3853	Toxic anion resistance protein (TelA)
I4W80_RS01735	COG0517	IMP dehydrogenase activity
I4W80_RS01735	COG4175	Glycine betaine
I4W80_RS01740	COG4176	ABC-type proline glycine betaine transport system permease component
I4W80_RS01745	COG2113	Glycine betaine
I4W80_RS01760	COG1473	amidohydrolase
I4W80_RS01765	COG1288	antiporter activity
I4W80_RS01770	COG0039	L-malate dehydrogenase activity
I4W80_RS01775	COG1620	l-lactate permease
I4W80_RS01780	COG1609	Transcriptional regulator
I4W80_RS01785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I4W80_RS01790	COG0561	phosphatase activity
I4W80_RS01795	COG0673	inositol 2-dehydrogenase activity
I4W80_RS01800	COG0738	Major facilitator superfamily
I4W80_RS01805	COG1280	lysine exporter protein (LysE YggA)
I4W80_RS01820	COG3403	YqcI/YcgG family
I4W80_RS01825	COG1113	amino acid transport
I4W80_RS01830	COG3665	Urea carboxylase-associated protein
I4W80_RS01835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I4W80_RS01845	COG1012	belongs to the aldehyde dehydrogenase family
I4W80_RS01850	COG0710	3-dehydroquinate dehydratase activity
I4W80_RS01855	COG0028	Belongs to the TPP enzyme family
I4W80_RS01865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I4W80_RS01870	COG2271	Major facilitator Superfamily
I4W80_RS01885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I4W80_RS01890	COG2226	methyltransferase
I4W80_RS01895	COG0583	DNA-binding transcription factor activity
I4W80_RS01900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I4W80_RS01905	COG3458	cephalosporin-C deacetylase activity
I4W80_RS01915	COG3541	Predicted nucleotidyltransferase
I4W80_RS01920	COG0506	proline dehydrogenase activity
I4W80_RS01925	COG1012	belongs to the aldehyde dehydrogenase family
I4W80_RS01930	COG2508	Transcriptional regulator
I4W80_RS01935	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I4W80_RS01940	COG0765	amino acid transport
I4W80_RS01945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4W80_RS01955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I4W80_RS01960	COG1522	sequence-specific DNA binding
I4W80_RS01965	COG2746	aminoglycoside 3-N-acetyltransferase activity
I4W80_RS01975	COG3290	protein histidine kinase activity
I4W80_RS01975	COG0840	transmembrane signaling receptor activity
I4W80_RS01980	COG3209	COG3209 Rhs family protein
I4W80_RS02000	COG3842	ATPase activity
I4W80_RS02005	COG1176	ABC-type spermidine putrescine transport system, permease component I
I4W80_RS02015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I4W80_RS02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I4W80_RS02025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I4W80_RS02040	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I4W80_RS02045	COG4555	ABC transporter
I4W80_RS02055	COG0697	spore germination
I4W80_RS02060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I4W80_RS02070	COG2207	Transcriptional regulator
I4W80_RS02070	COG3708	Transcriptional regulator
I4W80_RS02080	COG2364	Membrane
I4W80_RS02085	COG1126	abc transporter atp-binding protein
I4W80_RS02090	COG0765	amino acid transport
I4W80_RS02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4W80_RS02100	COG0833	amino acid
I4W80_RS02105	COG3104	oligopeptide transport
I4W80_RS02110	COG5434	Belongs to the glycosyl hydrolase 28 family
I4W80_RS02115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I4W80_RS02120	COG0456	acetyltransferase
I4W80_RS02125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4W80_RS02130	COG0765	amino acid transport
I4W80_RS02135	COG1126	abc transporter atp-binding protein
I4W80_RS02140	COG1473	amidohydrolase
I4W80_RS02145	COG2079	MmgE PrpD family protein
I4W80_RS02150	COG0745	RESPONSE REGULATOR receiver
I4W80_RS02155	COG5002	protein histidine kinase activity
I4W80_RS02155	COG3850	Histidine kinase
I4W80_RS02160	COG1366	Belongs to the anti-sigma-factor antagonist family
I4W80_RS02165	COG0527	aspartate kinase activity
I4W80_RS02170	COG2814	Major facilitator Superfamily
I4W80_RS02175	COG1309	transcriptional regulator
I4W80_RS02185	COG0640	Transcriptional regulator
I4W80_RS02195	COG0583	DNA-binding transcription factor activity
I4W80_RS02200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I4W80_RS02205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I4W80_RS02210	COG0531	amino acid
I4W80_RS02215	COG1012	belongs to the aldehyde dehydrogenase family
I4W80_RS02220	COG2249	NAD(P)H dehydrogenase (quinone) activity
I4W80_RS02225	COG4549	nuclear export factor GLE1
I4W80_RS02230	COG2372	response to copper ion
I4W80_RS02230	COG1276	copper resistance
I4W80_RS02235	COG2213	PTS system mannitol-specific
I4W80_RS02240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_RS02245	COG0246	Mannitol dehydrogenase
I4W80_RS02250	COG0840	transmembrane signaling receptor activity
I4W80_RS02285	COG0346	lactoylglutathione lyase activity
I4W80_RS02295	COG0561	phosphatase activity
I4W80_RS02345	COG0457	Tetratricopeptide repeat
I4W80_RS02350	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I4W80_RS02355	COG1914	H( )-stimulated, divalent metal cation uptake system
I4W80_RS02360	COG4336	lyase activity
I4W80_RS02365	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I4W80_RS02370	COG1984	allophanate hydrolase subunit 2
I4W80_RS02375	COG1414	Transcriptional regulator
I4W80_RS02380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I4W80_RS02385	COG2755	lipolytic protein G-D-S-L family
I4W80_RS02395	COG3711	transcriptional antiterminator
I4W80_RS02400	COG2226	methyltransferase
I4W80_RS02405	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS02410	COG3871	stress protein (general stress protein 26)
I4W80_RS02430	COG2814	Major facilitator Superfamily
I4W80_RS02435	COG1802	Transcriptional regulator
I4W80_RS02440	COG2207	Transcriptional regulator
I4W80_RS02440	COG1917	Cupin 2, conserved barrel domain protein
I4W80_RS02445	COG0697	spore germination
I4W80_RS02450	COG0473	3-isopropylmalate dehydrogenase activity
I4W80_RS02460	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I4W80_RS02465	COG3706	GGDEF domain
I4W80_RS02470	COG5298	Protein conserved in bacteria
I4W80_RS02475	COG1215	transferase activity, transferring glycosyl groups
I4W80_RS02485	COG0531	amino acid
I4W80_RS02490	COG0028	Belongs to the TPP enzyme family
I4W80_RS02495	COG5444	nuclease activity
I4W80_RS02515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I4W80_RS02520	COG1914	H( )-stimulated, divalent metal cation uptake system
I4W80_RS02525	COG2261	transglycosylase associated protein
I4W80_RS02530	COG2217	Heavy metal translocating P-type atpase
I4W80_RS02535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I4W80_RS02540	COG3290	protein histidine kinase activity
I4W80_RS02545	COG4565	transcriptional regulatory protein
I4W80_RS02550	COG1301	dicarboxylic acid transport
I4W80_RS02555	COG0628	permease
I4W80_RS02560	COG1301	dicarboxylic acid transport
I4W80_RS02565	COG1131	(ABC) transporter
I4W80_RS02570	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I4W80_RS02585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4W80_RS02590	COG1181	Belongs to the D-alanine--D-alanine ligase family
I4W80_RS02595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I4W80_RS02610	COG0513	Belongs to the DEAD box helicase family
I4W80_RS02615	COG3402	PFAM membrane-flanked domain
I4W80_RS02620	COG3428	Bacterial PH domain
I4W80_RS02625	COG0705	Rhomboid family
I4W80_RS02630	COG0736	holo-[acyl-carrier-protein] synthase activity
I4W80_RS02635	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I4W80_RS02640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I4W80_RS02645	COG0864	Transcriptional regulator
I4W80_RS02650	COG2337	Toxic component of a toxin-antitoxin (TA) module
I4W80_RS02655	COG1366	Belongs to the anti-sigma-factor antagonist family
I4W80_RS02660	COG1366	Belongs to the anti-sigma-factor antagonist family
I4W80_RS02665	COG2172	sigma factor antagonist activity
I4W80_RS02670	COG2208	phosphoserine phosphatase activity
I4W80_RS02675	COG1366	Belongs to the anti-sigma-factor antagonist family
I4W80_RS02680	COG2172	sigma factor antagonist activity
I4W80_RS02685	COG1191	sigma factor activity
I4W80_RS02690	COG2208	phosphoserine phosphatase activity
I4W80_RS02695	COG2183	response to ionizing radiation
I4W80_RS02705	COG3091	SprT-like family
I4W80_RS02710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I4W80_RS02715	COG0022	dehydrogenase e1 component
I4W80_RS02720	COG0508	dehydrogenase complex catalyzes the overall conversion of
I4W80_RS02725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I4W80_RS02730	COG3284	Transcriptional regulator
I4W80_RS02775	COG1278	Cold shock
I4W80_RS02790	COG2190	(PTS) system
I4W80_RS02790	COG1263	PTS System
I4W80_RS02790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_RS02795	COG3394	polysaccharide catabolic process
I4W80_RS02800	COG3711	transcriptional antiterminator
I4W80_RS02805	COG1064	alcohol dehydrogenase
I4W80_RS02810	COG0789	Transcriptional regulator
I4W80_RS02830	COG0477	Major facilitator Superfamily
I4W80_RS02835	COG0657	acetylesterase activity
I4W80_RS02845	COG4221	oxidoreductase activity
I4W80_RS02855	COG0252	asparaginase activity
I4W80_RS02875	COG2814	Major facilitator Superfamily
I4W80_RS02920	COG1309	transcriptional regulator
I4W80_RS02925	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I4W80_RS02930	COG1846	Transcriptional regulator
I4W80_RS02935	COG0778	Nitroreductase
I4W80_RS02950	COG1396	sequence-specific DNA binding
I4W80_RS02960	COG0456	acetyltransferase
I4W80_RS02970	COG4122	O-methyltransferase activity
I4W80_RS02980	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I4W80_RS02985	COG0697	spore germination
I4W80_RS02995	COG1301	dicarboxylic acid transport
I4W80_RS03035	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I4W80_RS03040	COG0802	atpase or kinase
I4W80_RS03045	COG1214	PFAM Peptidase M22, glycoprotease
I4W80_RS03050	COG0456	acetyltransferase
I4W80_RS03055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I4W80_RS03060	COG0488	(ABC) transporter
I4W80_RS03065	COG0315	cyclic pyranopterin monophosphate synthase activity
I4W80_RS03070	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I4W80_RS03075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I4W80_RS03080	COG0805	protein transport
I4W80_RS03095	COG1266	CAAX protease self-immunity
I4W80_RS03100	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I4W80_RS03105	COG0459	protein refolding
I4W80_RS03110	COG1846	Transcriptional regulator
I4W80_RS03115	COG2808	Putative FMN-binding domain
I4W80_RS03120	COG1876	peptidase activity
I4W80_RS03145	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I4W80_RS03150	COG0823	Involved in the tonB-independent uptake of proteins
I4W80_RS03160	COG2132	Multicopper oxidase
I4W80_RS03165	COG1113	amino acid transport
I4W80_RS03170	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I4W80_RS03175	COG0714	Associated with various cellular activities
I4W80_RS03180	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I4W80_RS03185	COG1305	Transglutaminase-like
I4W80_RS03190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I4W80_RS03190	COG0519	Catalyzes the synthesis of GMP from XMP
I4W80_RS03195	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I4W80_RS03205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I4W80_RS03230	COG1595	DNA-templated transcription, initiation
I4W80_RS03245	COG2814	Major facilitator Superfamily
I4W80_RS03250	COG0583	DNA-binding transcription factor activity
I4W80_RS03255	COG2252	PERMEase
I4W80_RS03265	COG5583	Uncharacterized small protein (DUF2292)
I4W80_RS03270	COG3064	Membrane
I4W80_RS03275	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I4W80_RS03285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I4W80_RS03290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I4W80_RS03295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I4W80_RS03300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I4W80_RS03305	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I4W80_RS03310	COG0047	phosphoribosylformylglycinamidine synthase activity
I4W80_RS03315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I4W80_RS03320	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I4W80_RS03325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I4W80_RS03330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I4W80_RS03335	COG0138	bifunctional purine biosynthesis protein purh
I4W80_RS03340	COG0151	Belongs to the GarS family
I4W80_RS03360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I4W80_RS03365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I4W80_RS03370	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I4W80_RS03375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I4W80_RS03385	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I4W80_RS03390	COG4496	protein, YerC YecD
I4W80_RS03400	COG0069	glutamate synthase activity
I4W80_RS03415	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I4W80_RS03420	COG0210	DNA helicase
I4W80_RS03425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I4W80_RS03430	COG4851	CamS sex pheromone cAM373 precursor
I4W80_RS03435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I4W80_RS03440	COG1285	pathogenesis
I4W80_RS03445	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I4W80_RS03450	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I4W80_RS03455	COG0154	amidase activity
I4W80_RS03460	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I4W80_RS03465	COG1309	transcriptional regulator
I4W80_RS03470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I4W80_RS03480	COG1597	lipid kinase activity
I4W80_RS03485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I4W80_RS03490	COG1106	Psort location Cytoplasmic, score
I4W80_RS03510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I4W80_RS03525	COG1959	2 iron, 2 sulfur cluster binding
I4W80_RS03530	COG0492	ferredoxin-NADP+ reductase activity
I4W80_RS03545	COG1486	melibiose metabolic process
I4W80_RS03555	COG2211	Major facilitator Superfamily
I4W80_RS03585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I4W80_RS03590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I4W80_RS03595	COG1442	glycosyl transferase family 8
I4W80_RS03600	COG1216	Glycosyl transferase, family 2
I4W80_RS03605	COG1442	glycosyl transferase family 8
I4W80_RS03610	COG2223	nitrite transmembrane transporter activity
I4W80_RS03620	COG0471	metal ion transport
I4W80_RS03635	COG0071	Belongs to the small heat shock protein (HSP20) family
I4W80_RS03650	COG0531	amino acid
I4W80_RS03655	COG0457	Tetratricopeptide repeat
I4W80_RS03655	COG0463	Glycosyl transferase, family 2
I4W80_RS03660	COG0488	(ABC) transporter
I4W80_RS03665	COG1469	GTP cyclohydrolase I activity
I4W80_RS03670	COG0789	Transcriptional regulator
I4W80_RS03675	COG2814	Major facilitator Superfamily
I4W80_RS03680	COG0488	(ABC) transporter
I4W80_RS03685	COG0513	Belongs to the DEAD box helicase family
I4W80_RS03690	COG2130	NADP-dependent
I4W80_RS03710	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I4W80_RS03710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I4W80_RS03715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I4W80_RS03725	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I4W80_RS03725	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I4W80_RS03735	COG3290	protein histidine kinase activity
I4W80_RS03740	COG4565	transcriptional regulatory protein
I4W80_RS03745	COG3181	Tripartite tricarboxylate transporter family receptor
I4W80_RS03750	COG2851	Citrate transporter
I4W80_RS03760	COG3479	Phenolic acid decarboxylase
I4W80_RS03765	COG1695	Transcriptional regulator
I4W80_RS03770	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I4W80_RS03780	COG1254	Belongs to the acylphosphatase family
I4W80_RS03785	COG2258	MOSC domain
I4W80_RS03800	COG0024	Methionine aminopeptidase
I4W80_RS03805	COG1263	PTS System
I4W80_RS03805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_RS03830	COG1368	sulfuric ester hydrolase activity
I4W80_RS03835	COG0076	glutamate decarboxylase activity
I4W80_RS03840	COG0840	transmembrane signaling receptor activity
I4W80_RS03850	COG1263	PTS System
I4W80_RS03850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_RS03855	COG0366	Alpha amylase catalytic
I4W80_RS03860	COG2188	Transcriptional regulator
I4W80_RS03870	COG0737	Belongs to the 5'-nucleotidase family
I4W80_RS03875	COG0693	protein deglycase activity
I4W80_RS03880	COG4840	Belongs to the UPF0435 family
I4W80_RS03885	COG1115	amino acid carrier protein
I4W80_RS03890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I4W80_RS03895	COG4980	gas vesicle protein
I4W80_RS03900	COG1295	ribonuclease BN
I4W80_RS03910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I4W80_RS03915	COG0477	Major facilitator Superfamily
I4W80_RS03925	COG0387	Pfam Sodium calcium exchanger
I4W80_RS03935	COG0217	transcriptional regulatory protein
I4W80_RS03945	COG0668	transmembrane transport
I4W80_RS03950	COG0535	radical SAM domain protein
I4W80_RS03960	COG0726	polysaccharide deacetylase
I4W80_RS03970	COG0598	Magnesium transport protein CorA
I4W80_RS03980	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I4W80_RS03985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I4W80_RS04015	COG0789	Transcriptional regulator
I4W80_RS04020	COG2814	Major facilitator Superfamily
I4W80_RS04035	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I4W80_RS04080	COG2076	Multidrug Resistance protein
I4W80_RS04085	COG2076	Multidrug Resistance protein
I4W80_RS04090	COG1309	transcriptional regulator
I4W80_RS04100	COG4637	Psort location Cytoplasmic, score
I4W80_RS04105	COG2755	lipolytic protein G-D-S-L family
I4W80_RS04110	COG0492	ferredoxin-NADP+ reductase activity
I4W80_RS04115	COG2169	Transcriptional regulator
I4W80_RS04120	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I4W80_RS04125	COG1132	(ABC) transporter
I4W80_RS04130	COG1742	UPF0060 membrane protein
I4W80_RS04135	COG1595	DNA-templated transcription, initiation
I4W80_RS04155	COG2318	DinB family
I4W80_RS04165	COG1846	Transcriptional regulator
I4W80_RS04170	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I4W80_RS04170	COG0392	lysyltransferase activity
I4W80_RS04190	COG0778	Nitroreductase
I4W80_RS04205	COG1090	epimerase
I4W80_RS04210	COG2137	regulation of response to DNA damage stimulus
I4W80_RS04235	COG0463	Glycosyl transferase, family 2
I4W80_RS04240	COG4485	Bacterial membrane protein, YfhO
I4W80_RS04245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I4W80_RS04260	COG2140	Oxalate decarboxylase
I4W80_RS04270	COG1191	sigma factor activity
I4W80_RS04280	COG1988	membrane-bound metal-dependent
I4W80_RS04285	COG1194	a g-specific adenine glycosylase
I4W80_RS04295	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS04310	COG3557	Belongs to the UPF0374 family
I4W80_RS04315	COG1132	(ABC) transporter
I4W80_RS04320	COG0444	Belongs to the ABC transporter superfamily
I4W80_RS04325	COG4608	Belongs to the ABC transporter superfamily
I4W80_RS04330	COG0747	negative chemotaxis
I4W80_RS04335	COG0601	transmembrane transport
I4W80_RS04340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I4W80_RS04345	COG4129	membrane
I4W80_RS04350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I4W80_RS04355	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I4W80_RS04360	COG0735	belongs to the Fur family
I4W80_RS04505	COG1368	sulfuric ester hydrolase activity
I4W80_RS04510	COG0681	Belongs to the peptidase S26 family
I4W80_RS04515	COG2873	o-acetylhomoserine
I4W80_RS04525	COG1116	anion transmembrane transporter activity
I4W80_RS04530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I4W80_RS04535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I4W80_RS04540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I4W80_RS04555	COG1131	(ABC) transporter
I4W80_RS04585	COG3382	B3 4 domain protein
I4W80_RS04590	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I4W80_RS04600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I4W80_RS04605	COG2766	serine protein kinase
I4W80_RS04610	COG2718	Belongs to the UPF0229 family
I4W80_RS04615	COG1566	PFAM secretion protein HlyD family protein
I4W80_RS04620	COG2814	Major facilitator Superfamily
I4W80_RS04625	COG0655	NAD(P)H dehydrogenase (quinone) activity
I4W80_RS04635	COG1278	Cold shock
I4W80_RS04640	COG3706	GGDEF domain
I4W80_RS04665	COG5577	PFAM Coat F domain
I4W80_RS04670	COG5002	protein histidine kinase activity
I4W80_RS04675	COG0737	Belongs to the 5'-nucleotidase family
I4W80_RS04675	COG1525	nuclease
I4W80_RS04675	COG4085	toxin activity
I4W80_RS04680	COG3764	Sortase (surface protein transpeptidase)
I4W80_RS04690	COG0564	pseudouridine synthase activity
I4W80_RS04700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I4W80_RS04705	COG3153	acetyltransferase
I4W80_RS04705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I4W80_RS04725	COG3835	regulator
I4W80_RS04730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I4W80_RS04735	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I4W80_RS04740	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I4W80_RS04745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I4W80_RS04750	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I4W80_RS04755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I4W80_RS04760	COG2203	Gaf domain
I4W80_RS04760	COG4585	Histidine kinase
I4W80_RS04765	COG2197	response regulator
I4W80_RS04780	COG0753	catalase activity
I4W80_RS04785	COG1959	2 iron, 2 sulfur cluster binding
I4W80_RS04790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I4W80_RS04790	COG1017	nitric oxide dioxygenase activity
I4W80_RS04795	COG2719	SpoVR family
I4W80_RS04800	COG1785	Belongs to the alkaline phosphatase family
I4W80_RS04805	COG0791	NLP P60 protein
I4W80_RS04805	COG1388	LysM domain
I4W80_RS04810	COG0531	amino acid
I4W80_RS04825	COG1595	DNA-templated transcription, initiation
I4W80_RS04830	COG0204	Acyl-transferase
I4W80_RS04835	COG1253	flavin adenine dinucleotide binding
I4W80_RS04840	COG0789	Transcriptional regulator
I4W80_RS04845	COG1253	flavin adenine dinucleotide binding
I4W80_RS04860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I4W80_RS04865	COG0584	glycerophosphoryl diester phosphodiesterase
I4W80_RS04875	COG0668	transmembrane transport
I4W80_RS04880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I4W80_RS04885	COG0726	polysaccharide deacetylase
I4W80_RS04890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I4W80_RS04895	COG0589	response to stress
I4W80_RS04900	COG1132	(ABC) transporter
I4W80_RS04905	COG1132	(ABC) transporter
I4W80_RS04910	COG0702	epimerase
I4W80_RS04920	COG3842	ATPase activity
I4W80_RS04925	COG2508	Transcriptional regulator
I4W80_RS04935	COG0189	ligase activity
I4W80_RS04940	COG0189	ligase activity
I4W80_RS04945	COG4399	Belongs to the UPF0754 family
I4W80_RS04950	COG3679	Belongs to the UPF0342 family
I4W80_RS04955	COG0561	phosphatase activity
I4W80_RS04960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I4W80_RS04970	COG0475	glutathione-regulated potassium exporter activity
I4W80_RS04975	COG0490	domain, Protein
I4W80_RS04985	COG1024	Enoyl-CoA hydratase
I4W80_RS04995	COG0420	3'-5' exonuclease activity
I4W80_RS05000	COG4717	serine-type aminopeptidase activity
I4W80_RS05005	COG3481	metal-dependent phosphohydrolase, HD sub domain
I4W80_RS05015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I4W80_RS05040	COG1846	Transcriptional regulator
I4W80_RS05045	COG4980	gas vesicle protein
I4W80_RS05060	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I4W80_RS05065	COG0537	adenosine 5'-monophosphoramidase activity
I4W80_RS05070	COG1131	(ABC) transporter
I4W80_RS05075	COG4473	ABC transporter
I4W80_RS05085	COG1473	amidohydrolase
I4W80_RS05090	COG2329	Antibiotic biosynthesis monooxygenase
I4W80_RS05095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I4W80_RS05100	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I4W80_RS05105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I4W80_RS05110	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I4W80_RS05115	COG1309	transcriptional regulator
I4W80_RS05120	COG1511	domain protein
I4W80_RS05125	COG1363	Peptidase, m42
I4W80_RS05130	COG1301	dicarboxylic acid transport
I4W80_RS05140	COG1234	tRNA 3'-trailer cleavage
I4W80_RS05145	COG0095	Lipoate-protein ligase
I4W80_RS05150	COG0318	PFAM AMP-dependent synthetase and ligase
I4W80_RS05160	COG0501	Belongs to the peptidase M48B family
I4W80_RS05165	COG1404	Belongs to the peptidase S8 family
I4W80_RS05170	COG0406	alpha-ribazole phosphatase activity
I4W80_RS05175	COG0840	transmembrane signaling receptor activity
I4W80_RS05180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I4W80_RS05180	COG0723	plastoquinol--plastocyanin reductase activity
I4W80_RS05185	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS05195	COG4903	ComK protein
I4W80_RS05210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I4W80_RS05215	COG2814	Major facilitator Superfamily
I4W80_RS05220	COG2732	(Barnase) inhibitor
I4W80_RS05225	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_RS05230	COG4605	iron ion homeostasis
I4W80_RS05235	COG4604	ABC transporter, ATP-binding protein
I4W80_RS05240	COG4607	ABC-type enterochelin transport system periplasmic component
I4W80_RS05245	COG1316	TRANSCRIPTIONal
I4W80_RS05260	COG0398	Pfam SNARE associated Golgi protein
I4W80_RS05265	COG0681	Belongs to the peptidase S26 family
I4W80_RS05270	COG3180	Ammonia monooxygenase
I4W80_RS05285	COG2259	Doxx family
I4W80_RS05290	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I4W80_RS05295	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I4W80_RS05300	COG1074	ATP-dependent DNA helicase activity
I4W80_RS05305	COG0420	3'-5' exonuclease activity
I4W80_RS05310	COG0419	ATPase involved in DNA repair
I4W80_RS05315	COG1403	HNH endonuclease
I4W80_RS05355	COG5337	Spore coat protein CotH
I4W80_RS05365	COG0179	Fumarylacetoacetate (FAA) hydrolase
I4W80_RS05380	COG0367	asparagine synthase
I4W80_RS05395	COG1562	ergosterol biosynthetic process
I4W80_RS05400	COG0534	Mate efflux family protein
I4W80_RS05405	COG1917	Cupin 2, conserved barrel domain protein
I4W80_RS05405	COG2207	Transcriptional regulator
I4W80_RS05430	COG0076	glutamate decarboxylase activity
I4W80_RS05465	COG0646	methionine synthase
I4W80_RS05465	COG1410	methionine synthase
I4W80_RS05470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I4W80_RS05470	COG0646	methionine synthase
I4W80_RS05475	COG1666	GTP binding
I4W80_RS05480	COG2996	Protein conserved in bacteria
I4W80_RS05485	COG1744	ABC transporter substrate-binding protein PnrA-like
I4W80_RS05490	COG0840	transmembrane signaling receptor activity
I4W80_RS05495	COG1307	EDD domain protein, DegV family
I4W80_RS05500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4W80_RS05520	COG0561	phosphatase activity
I4W80_RS05525	COG1073	alpha beta
I4W80_RS05530	COG2151	metal-sulfur cluster biosynthetic enzyme
I4W80_RS05535	COG0277	FAD linked oxidase domain protein
I4W80_RS05540	COG2271	Major facilitator Superfamily
I4W80_RS05545	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I4W80_RS05550	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I4W80_RS05555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I4W80_RS05560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I4W80_RS05565	COG0505	Belongs to the CarA family
I4W80_RS05570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I4W80_RS05575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I4W80_RS05585	COG2814	Major facilitator Superfamily
I4W80_RS05595	COG2267	carboxylic ester hydrolase activity
I4W80_RS05605	COG1744	ABC transporter substrate-binding protein PnrA-like
I4W80_RS05620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I4W80_RS05625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I4W80_RS05630	COG5504	Zn-dependent protease
I4W80_RS05635	COG0444	Belongs to the ABC transporter superfamily
I4W80_RS05640	COG4608	Belongs to the ABC transporter superfamily
I4W80_RS05650	COG0601	transmembrane transport
I4W80_RS05655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I4W80_RS05665	COG0180	Tryptophanyl-tRNA synthetase
I4W80_RS05670	COG4166	transmembrane transport
I4W80_RS05675	COG0601	transmembrane transport
I4W80_RS05680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I4W80_RS05685	COG0444	Belongs to the ABC transporter superfamily
I4W80_RS05690	COG4608	Belongs to the ABC transporter superfamily
I4W80_RS05700	COG0456	acetyltransferase
I4W80_RS05705	COG1393	Belongs to the ArsC family
I4W80_RS05710	COG0861	Integral membrane protein TerC family
I4W80_RS05715	COG4862	establishment of competence for transformation
I4W80_RS05720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I4W80_RS05730	COG1164	Oligoendopeptidase f
I4W80_RS05740	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I4W80_RS05745	COG2346	COG2346, Truncated hemoglobins
I4W80_RS05750	COG0741	lytic transglycosylase activity
I4W80_RS05755	COG4116	CYTH
I4W80_RS05765	COG2357	RelA SpoT domain protein
I4W80_RS05770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I4W80_RS05775	COG0564	pseudouridine synthase activity
I4W80_RS05780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I4W80_RS05785	COG0569	domain protein
I4W80_RS05785	COG0475	glutathione-regulated potassium exporter activity
I4W80_RS05790	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I4W80_RS05795	COG0352	thiamine-phosphate diphosphorylase activity
I4W80_RS05805	COG2104	thiamine diphosphate biosynthetic process
I4W80_RS05810	COG2022	thiamine diphosphate biosynthetic process
I4W80_RS05815	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I4W80_RS05820	COG0351	phosphomethylpyrimidine kinase
I4W80_RS05825	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I4W80_RS05880	COG0210	DNA helicase
I4W80_RS05890	COG2153	protein acetylation
I4W80_RS05895	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I4W80_RS05900	COG2382	esterase
I4W80_RS05905	COG0626	cystathionine gamma-synthase activity
I4W80_RS05910	COG0626	cystathionine gamma-synthase activity
I4W80_RS05920	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I4W80_RS05940	COG0604	alcohol dehydrogenase
I4W80_RS05955	COG0825	malonyl-CoA metabolic process
I4W80_RS05970	COG0457	Tetratricopeptide repeat
I4W80_RS05980	COG2153	protein acetylation
I4W80_RS05985	COG2364	Membrane
I4W80_RS06000	COG0300	oxidoreductase activity
I4W80_RS06015	COG3173	Aminoglycoside phosphotransferase
I4W80_RS06020	COG0583	DNA-binding transcription factor activity
I4W80_RS06040	COG0583	DNA-binding transcription factor activity
I4W80_RS06045	COG2807	transmembrane transport
I4W80_RS06070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I4W80_RS06080	COG1309	transcriptional regulator
I4W80_RS06090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I4W80_RS06095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I4W80_RS06100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I4W80_RS06105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I4W80_RS06125	COG4195	phage-related replication protein
I4W80_RS06130	COG2856	Zn peptidase
I4W80_RS06135	COG5632	N-Acetylmuramoyl-L-alanine amidase
I4W80_RS06135	COG3409	Peptidoglycan-binding domain 1 protein
I4W80_RS06150	COG0306	phosphate transporter
I4W80_RS06155	COG1392	Phosphate transport regulator
I4W80_RS06165	COG0405	Gamma-glutamyltransferase
I4W80_RS06170	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I4W80_RS06180	COG4208	sulfate ABC transporter
I4W80_RS06185	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I4W80_RS06195	COG3775	system Galactitol-specific IIC component
I4W80_RS06210	COG1063	alcohol dehydrogenase
I4W80_RS06215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I4W80_RS06220	COG0022	dehydrogenase e1 component
I4W80_RS06220	COG0508	dehydrogenase complex catalyzes the overall conversion of
I4W80_RS06225	COG0508	dehydrogenase complex catalyzes the overall conversion of
I4W80_RS06230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I4W80_RS06235	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS06240	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS06245	COG2390	Transcriptional regulator
I4W80_RS06255	COG0531	amino acid
I4W80_RS06260	COG0346	lactoylglutathione lyase activity
I4W80_RS06265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I4W80_RS06270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I4W80_RS06275	COG2362	D-Aminopeptidase
I4W80_RS06280	COG0601	transmembrane transport
I4W80_RS06285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I4W80_RS06290	COG0444	Belongs to the ABC transporter superfamily
I4W80_RS06295	COG4166	transmembrane transport
I4W80_RS06300	COG1619	proteins homologs of microcin C7 resistance protein MccF
I4W80_RS06305	COG4948	Mandelate Racemase Muconate Lactonizing
I4W80_RS06310	COG0791	NLP P60 protein
I4W80_RS06315	COG4608	Belongs to the ABC transporter superfamily
I4W80_RS06320	COG1834	amidinotransferase
I4W80_RS06325	COG1607	acyl-coa hydrolase
I4W80_RS06330	COG1695	Transcriptional regulator
I4W80_RS06345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I4W80_RS06355	COG2076	Multidrug Resistance protein
I4W80_RS06360	COG2076	Multidrug Resistance protein
I4W80_RS06370	COG0788	formyltetrahydrofolate deformylase activity
I4W80_RS06375	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I4W80_RS06380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I4W80_RS06385	COG0457	Tetratricopeptide repeat
I4W80_RS06395	COG1764	response to oxidative stress
I4W80_RS06400	COG1846	Transcriptional regulator
I4W80_RS06405	COG1764	response to oxidative stress
I4W80_RS06410	COG0590	tRNA wobble adenosine to inosine editing
I4W80_RS06415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I4W80_RS06420	COG1404	Belongs to the peptidase S8 family
I4W80_RS06435	COG0745	RESPONSE REGULATOR receiver
I4W80_RS06440	COG5002	protein histidine kinase activity
I4W80_RS06440	COG3850	Histidine kinase
I4W80_RS06445	COG3212	peptidase
I4W80_RS06450	COG3212	peptidase
I4W80_RS06460	COG2239	Acts as a magnesium transporter
I4W80_RS06470	COG0583	DNA-binding transcription factor activity
I4W80_RS06480	COG0789	Transcriptional regulator
I4W80_RS06495	COG1846	Transcriptional regulator
I4W80_RS06500	COG5001	Diguanylate cyclase
I4W80_RS06500	COG3300	MHYT domain
I4W80_RS06505	COG0586	Pfam SNARE associated Golgi protein
I4W80_RS06510	COG0861	Integral membrane protein TerC family
I4W80_RS06515	COG1191	sigma factor activity
I4W80_RS06535	COG0501	Belongs to the peptidase M48B family
I4W80_RS06540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I4W80_RS06545	COG2323	membrane
I4W80_RS06560	COG3594	Acyltransferase
I4W80_RS06565	COG5002	protein histidine kinase activity
I4W80_RS06570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I4W80_RS06575	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I4W80_RS06580	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
I4W80_RS06585	COG0436	Aminotransferase
I4W80_RS06590	COG1850	ribulose-bisphosphate carboxylase activity
I4W80_RS06595	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
I4W80_RS06600	COG0235	Class ii aldolase
I4W80_RS06605	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I4W80_RS06615	COG3852	Histidine kinase
I4W80_RS06620	COG1846	Transcriptional regulator
I4W80_RS06625	COG1360	Flagellar Motor Protein
I4W80_RS06630	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I4W80_RS06640	COG0542	response to heat
I4W80_RS06645	COG3949	Membrane
I4W80_RS06650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I4W80_RS06655	COG0720	synthase
I4W80_RS06660	COG0602	queuosine metabolic process
I4W80_RS06665	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I4W80_RS06675	COG4873	Protein conserved in bacteria
I4W80_RS06685	COG3773	Cell wall hydrolase
I4W80_RS06690	COG2244	polysaccharide biosynthetic process
I4W80_RS06695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4W80_RS06700	COG2217	Heavy metal translocating P-type atpase
I4W80_RS06705	COG0006	proline dipeptidase activity
I4W80_RS06710	COG1609	Transcriptional regulator
I4W80_RS06715	COG3711	transcriptional antiterminator
I4W80_RS06720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_RS06720	COG1263	PTS System
I4W80_RS06720	COG2190	(PTS) system
I4W80_RS06725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_RS06730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I4W80_RS06740	COG1533	DNA photolyase activity
I4W80_RS06745	COG0840	transmembrane signaling receptor activity
I4W80_RS06755	COG2084	Dehydrogenase
I4W80_RS06760	COG2340	Cysteine-rich secretory protein family
I4W80_RS06765	COG0768	penicillin binding
I4W80_RS06770	COG4191	Histidine kinase
I4W80_RS06775	COG0436	Aminotransferase
I4W80_RS06780	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I4W80_RS06790	COG1714	RDD family
I4W80_RS06800	COG0784	Response regulator, receiver
I4W80_RS06800	COG0835	chemotaxis
I4W80_RS06820	COG2814	Major facilitator Superfamily
I4W80_RS06825	COG1376	ErfK ybiS ycfS ynhG family protein
I4W80_RS06830	COG1408	metallophosphoesterase
I4W80_RS06835	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS06840	COG2200	EAL domain
I4W80_RS06845	COG3546	catalase activity
I4W80_RS06850	COG4703	Protein of unknown function (DUF1797)
I4W80_RS06855	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I4W80_RS06865	COG0517	IMP dehydrogenase activity
I4W80_RS06870	COG0583	DNA-binding transcription factor activity
I4W80_RS06880	COG0716	FMN binding
I4W80_RS06890	COG0716	FMN binding
I4W80_RS06895	COG2171	N-acyltransferase activity
I4W80_RS06900	COG1473	amidohydrolase
I4W80_RS06910	COG0668	transmembrane transport
I4W80_RS06915	COG0450	alkyl hydroperoxide reductase
I4W80_RS06920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4W80_RS06935	COG0746	molybdenum cofactor guanylyltransferase activity
I4W80_RS06940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I4W80_RS06945	COG0303	'Molybdopterin
I4W80_RS06950	COG1763	Mo-molybdopterin cofactor biosynthetic process
I4W80_RS06955	COG0314	molybdopterin synthase activity
I4W80_RS06960	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I4W80_RS06975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I4W80_RS06980	COG1136	(ABC) transporter
I4W80_RS06985	COG0577	efflux transmembrane transporter activity
I4W80_RS06990	COG1349	DNA-binding transcription factor activity
I4W80_RS06995	COG1105	Belongs to the carbohydrate kinase PfkB family
I4W80_RS07000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4W80_RS07000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_RS07000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4W80_RS07005	COG0681	Belongs to the peptidase S26 family
I4W80_RS07015	COG0488	(ABC) transporter
I4W80_RS07020	COG2309	aminopeptidase activity
I4W80_RS07030	COG1077	Cell shape determining protein MreB Mrl
I4W80_RS07035	COG2002	toxin-antitoxin pair type II binding
I4W80_RS07040	COG3852	Histidine kinase
I4W80_RS07045	COG2105	PFAM AIG2 family protein
I4W80_RS07045	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I4W80_RS07050	COG0569	domain protein
I4W80_RS07055	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I4W80_RS07060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I4W80_RS07065	COG5503	Protein of unknown function (DUF1447)
I4W80_RS07070	COG0561	phosphatase activity
I4W80_RS07075	COG0242	peptide deformylase activity
I4W80_RS07090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I4W80_RS07095	COG0022	dehydrogenase e1 component
I4W80_RS07100	COG0508	dehydrogenase complex catalyzes the overall conversion of
I4W80_RS07105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I4W80_RS07110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4W80_RS07120	COG1982	Orn Lys Arg decarboxylase major
I4W80_RS07125	COG4476	Belongs to the UPF0223 family
I4W80_RS07130	COG4493	Belongs to the UPF0637 family
I4W80_RS07140	COG0483	inositol monophosphate 1-phosphatase activity
I4W80_RS07155	COG1595	DNA-templated transcription, initiation
I4W80_RS07175	COG1217	gtp-binding protein TYPA
I4W80_RS07185	COG4896	Protein conserved in bacteria
I4W80_RS07195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I4W80_RS07200	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I4W80_RS07205	COG2066	Belongs to the glutaminase family
I4W80_RS07210	COG4838	Belongs to the UPF0358 family
I4W80_RS07215	COG0772	Belongs to the SEDS family
I4W80_RS07220	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I4W80_RS07225	COG0415	Belongs to the DNA photolyase family
I4W80_RS07230	COG1612	heme a metabolic process
I4W80_RS07235	COG0109	protoheme IX farnesyltransferase activity
I4W80_RS07240	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I4W80_RS07240	COG2010	Cytochrome c
I4W80_RS07245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I4W80_RS07250	COG1845	cytochrome c oxidase, subunit III
I4W80_RS07255	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I4W80_RS07260	COG3336	cytochrome c oxidase
I4W80_RS07270	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I4W80_RS07275	COG2340	Cysteine-rich secretory protein family
I4W80_RS07295	COG3679	Belongs to the UPF0342 family
I4W80_RS07300	COG4471	UPF0298 protein
I4W80_RS07305	COG0742	ribosomal rna small subunit methyltransferase
I4W80_RS07310	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I4W80_RS07315	COG3314	Sporulation integral membrane protein YlbJ
I4W80_RS07320	COG1752	Esterase of the alpha-beta hydrolase superfamily
I4W80_RS07325	COG3480	Lon protease (S16) C-terminal proteolytic domain
I4W80_RS07335	COG1399	metal-binding, possibly nucleic acid-binding protein
I4W80_RS07340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I4W80_RS07350	COG0454	-acetyltransferase
I4W80_RS07355	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I4W80_RS07360	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I4W80_RS07365	COG2001	Belongs to the MraZ family
I4W80_RS07370	COG0275	rRNA processing
I4W80_RS07375	COG4839	cell division protein FtsL
I4W80_RS07380	COG0768	penicillin binding
I4W80_RS07385	COG0768	penicillin binding
I4W80_RS07390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I4W80_RS07395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I4W80_RS07400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I4W80_RS07405	COG0772	Belongs to the SEDS family
I4W80_RS07410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I4W80_RS07415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I4W80_RS07420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I4W80_RS07425	COG3879	Bacterial protein of unknown function (DUF881)
I4W80_RS07430	COG3879	Bacterial protein of unknown function (DUF881)
I4W80_RS07435	COG3856	small basic protein
I4W80_RS07440	COG0849	cell division
I4W80_RS07445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I4W80_RS07450	COG1404	Belongs to the peptidase S8 family
I4W80_RS07450	COG4412	M6 family metalloprotease domain protein
I4W80_RS07460	COG1191	sigma factor activity
I4W80_RS07465	COG1191	sigma factor activity
I4W80_RS07470	COG2390	Transcriptional regulator
I4W80_RS07485	COG3730	PTS system glucitol sorbitol-specific
I4W80_RS07490	COG3732	PTS system glucitol sorbitol-specific
I4W80_RS07500	COG1119	ATPase activity
I4W80_RS07505	COG1873	PFAM PRC-barrel domain
I4W80_RS07510	COG1496	oxidoreductase activity
I4W80_RS07515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I4W80_RS07520	COG1799	cell septum assembly
I4W80_RS07525	COG0762	integral membrane protein
I4W80_RS07530	COG2302	S4 RNA-binding domain
I4W80_RS07535	COG3599	regulation of cell shape
I4W80_RS07540	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I4W80_RS07545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I4W80_RS07550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I4W80_RS07555	COG0564	pseudouridine synthase activity
I4W80_RS07560	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I4W80_RS07565	COG2233	PERMEase
I4W80_RS07570	COG0540	Belongs to the ATCase OTCase family
I4W80_RS07575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I4W80_RS07580	COG0505	Belongs to the CarA family
I4W80_RS07585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I4W80_RS07590	COG0543	2 iron, 2 sulfur cluster binding
I4W80_RS07595	COG0167	dihydroorotate dehydrogenase activity
I4W80_RS07600	COG0284	orotidine-5'-phosphate decarboxylase activity
I4W80_RS07605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I4W80_RS07615	COG0175	sulfate reduction
I4W80_RS07620	COG0306	phosphate transporter
I4W80_RS07625	COG2046	Belongs to the sulfate adenylyltransferase family
I4W80_RS07630	COG0529	Catalyzes the synthesis of activated sulfate
I4W80_RS07635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I4W80_RS07640	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
I4W80_RS07645	COG1648	precorrin-2 dehydrogenase activity
I4W80_RS07655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I4W80_RS07660	COG1561	YicC-like family, N-terminal region
I4W80_RS07665	COG2052	Domain of unknown function (DUF370)
I4W80_RS07670	COG0194	GDP metabolic process
I4W80_RS07675	COG1758	RNA polymerase activity
I4W80_RS07680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I4W80_RS07685	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I4W80_RS07690	COG0242	peptide deformylase activity
I4W80_RS07695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I4W80_RS07700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I4W80_RS07700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I4W80_RS07705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I4W80_RS07710	COG0631	protein serine/threonine phosphatase activity
I4W80_RS07715	COG2815	serine threonine protein kinase
I4W80_RS07715	COG0515	serine threonine protein kinase
I4W80_RS07720	COG1162	GTPase activity
I4W80_RS07725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I4W80_RS07730	COG1564	THIamine pyrophosphokinase
I4W80_RS07740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I4W80_RS07745	COG1302	Protein conserved in bacteria
I4W80_RS07750	COG1461	Dihydroxyacetone kinase
I4W80_RS07755	COG1760	l-serine dehydratase
I4W80_RS07760	COG1760	l-serine dehydratase
I4W80_RS07765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I4W80_RS07770	COG1349	DNA-binding transcription factor activity
I4W80_RS07775	COG0416	fatty acid biosynthetic process
I4W80_RS07780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I4W80_RS07785	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS07790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I4W80_RS07800	COG1196	nuclear chromosome segregation
I4W80_RS07805	COG0552	protein localization to endoplasmic reticulum
I4W80_RS07810	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I4W80_RS07815	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I4W80_RS07820	COG0228	four-way junction DNA binding
I4W80_RS07825	COG1837	Belongs to the UPF0109 family
I4W80_RS07835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I4W80_RS07840	COG0336	Belongs to the RNA methyltransferase TrmD family
I4W80_RS07845	COG0335	large ribosomal subunit rRNA binding
I4W80_RS07850	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I4W80_RS07855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I4W80_RS07865	COG2257	FlhB HrpN YscU SpaS Family
I4W80_RS07870	COG0045	succinate-CoA ligase (ADP-forming) activity
I4W80_RS07875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I4W80_RS07880	COG0758	DNA mediated transformation
I4W80_RS07885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I4W80_RS07890	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I4W80_RS07895	COG4974	Belongs to the 'phage' integrase family
I4W80_RS07900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I4W80_RS07905	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I4W80_RS07910	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I4W80_RS07915	COG1815	bacterial-type flagellum-dependent cell motility
I4W80_RS07920	COG1558	bacterial-type flagellum-dependent cell motility
I4W80_RS07925	COG1677	Flagellar hook-basal body complex protein FliE
I4W80_RS07930	COG1766	The M ring may be actively involved in energy transduction
I4W80_RS07935	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I4W80_RS07940	COG1317	bacterial-type flagellum organization
I4W80_RS07945	COG1157	protein secretion by the type III secretion system
I4W80_RS07950	COG2882	bacterial-type flagellum organization
I4W80_RS07955	COG3334	PFAM MgtE intracellular
I4W80_RS07960	COG3144	bacterial-type flagellum assembly
I4W80_RS07965	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I4W80_RS07970	COG4786	Flagellar basal body rod
I4W80_RS07975	COG1582	Flagellar protein (FlbD)
I4W80_RS07980	COG1580	Controls the rotational direction of flagella during chemotaxis
I4W80_RS07985	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I4W80_RS07990	COG1776	CheC inhibitor of MCP methylation
I4W80_RS07990	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I4W80_RS07995	COG2201	protein-glutamate methylesterase activity
I4W80_RS08000	COG3190	flagellar
I4W80_RS08005	COG1338	Plays a role in the flagellum-specific transport system
I4W80_RS08010	COG1987	bacterial-type flagellum assembly
I4W80_RS08015	COG1684	flagellar biosynthetic protein fliR
I4W80_RS08020	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I4W80_RS08025	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I4W80_RS08030	COG1419	protein localization to endoplasmic reticulum
I4W80_RS08035	COG0455	bacterial-type flagellum organization
I4W80_RS08040	COG2201	protein-glutamate methylesterase activity
I4W80_RS08045	COG0643	Histidine kinase
I4W80_RS08045	COG2198	Histidine kinase
I4W80_RS08050	COG0835	chemotaxis
I4W80_RS08055	COG1776	CheC inhibitor of MCP methylation
I4W80_RS08065	COG1191	sigma factor activity
I4W80_RS08080	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I4W80_RS08085	COG0528	UMP kinase activity
I4W80_RS08090	COG0233	cytoplasmic translational termination
I4W80_RS08095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I4W80_RS08100	COG4589	Belongs to the CDS family
I4W80_RS08105	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I4W80_RS08110	COG0750	zinc metalloprotease
I4W80_RS08115	COG0442	prolyl-tRNA aminoacylation
I4W80_RS08120	COG2176	DNA-directed DNA polymerase activity
I4W80_RS08135	COG3693	PFAM glycoside hydrolase, family 10
I4W80_RS08145	COG0779	Required for maturation of 30S ribosomal subunits
I4W80_RS08150	COG0195	Participates in both transcription termination and antitermination
I4W80_RS08155	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I4W80_RS08160	COG1358	cellular component organization or biogenesis
I4W80_RS08165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I4W80_RS08170	COG1550	Protein conserved in bacteria
I4W80_RS08175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I4W80_RS08180	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I4W80_RS08185	COG0196	riboflavin kinase activity
I4W80_RS08190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I4W80_RS08195	COG1185	polyribonucleotide nucleotidyltransferase activity
I4W80_RS08200	COG0726	polysaccharide deacetylase
I4W80_RS08205	COG0612	Peptidase, M16
I4W80_RS08215	COG1873	PFAM PRC-barrel domain
I4W80_RS08220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I4W80_RS08225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I4W80_RS08230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I4W80_RS08235	COG0527	aspartate kinase activity
I4W80_RS08245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I4W80_RS08250	COG0740	serine-type endopeptidase activity
I4W80_RS08260	COG1674	ftsk spoiiie
I4W80_RS08260	COG4980	gas vesicle protein
I4W80_RS08265	COG2188	Transcriptional regulator
I4W80_RS08270	COG2814	Major facilitator Superfamily
I4W80_RS08275	COG2409	Drug exporters of the RND superfamily
I4W80_RS08275	COG1033	growth of symbiont in host cell
I4W80_RS08280	COG0612	Peptidase, M16
I4W80_RS08285	COG0612	Peptidase, M16
I4W80_RS08295	COG1033	growth of symbiont in host cell
I4W80_RS08295	COG2409	Drug exporters of the RND superfamily
I4W80_RS08300	COG0300	oxidoreductase activity
I4W80_RS08315	COG1426	Protein conserved in bacteria
I4W80_RS08320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I4W80_RS08325	COG1546	Belongs to the CinA family
I4W80_RS08325	COG1058	Belongs to the CinA family
I4W80_RS08330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I4W80_RS08335	COG1418	mRNA catabolic process
I4W80_RS08340	COG1692	metallophosphoesterase
I4W80_RS08345	COG2359	stage V sporulation protein S
I4W80_RS08350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I4W80_RS08355	COG1063	alcohol dehydrogenase
I4W80_RS08360	COG0156	8-amino-7-oxononanoate synthase activity
I4W80_RS08365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I4W80_RS08370	COG4550	Control of competence regulator ComK, YlbF/YmcA
I4W80_RS08380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I4W80_RS08385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I4W80_RS08405	COG1329	Transcriptional regulator
I4W80_RS08410	COG4195	phage-related replication protein
I4W80_RS08415	COG0457	Tetratricopeptide repeat
I4W80_RS08420	COG1404	Belongs to the peptidase S8 family
I4W80_RS08425	COG4195	phage-related replication protein
I4W80_RS08430	COG1764	response to oxidative stress
I4W80_RS08460	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I4W80_RS08465	COG1923	regulation of RNA biosynthetic process
I4W80_RS08480	COG1780	Probably involved in ribonucleotide reductase function
I4W80_RS08485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I4W80_RS08490	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I4W80_RS08495	COG4112	unkown
I4W80_RS08505	COG0464	growth
I4W80_RS08510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I4W80_RS08515	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I4W80_RS08520	COG0789	Transcriptional regulator
I4W80_RS08525	COG0174	glutamine synthetase
I4W80_RS08545	COG0494	nUDIX hydrolase
I4W80_RS08550	COG0457	Tetratricopeptide repeat
I4W80_RS08565	COG5444	nuclease activity
I4W80_RS08590	COG5646	InterPro IPR014922
I4W80_RS08610	COG0457	Tetratricopeptide repeat
I4W80_RS08620	COG3619	membrane
I4W80_RS08625	COG3285	dna ligase
I4W80_RS08625	COG1793	dna ligase
I4W80_RS08630	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I4W80_RS08635	COG4876	unkown
I4W80_RS08645	COG1959	2 iron, 2 sulfur cluster binding
I4W80_RS08650	COG0702	epimerase
I4W80_RS08660	COG0247	lactate metabolic process
I4W80_RS08665	COG1139	Iron-sulfur cluster binding protein
I4W80_RS08670	COG1556	Lactate utilization protein
I4W80_RS08690	COG2323	membrane
I4W80_RS08695	COG1309	transcriptional regulator
I4W80_RS08700	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I4W80_RS08700	COG2124	cytochrome p450
I4W80_RS08705	COG3591	Belongs to the peptidase S1B family
I4W80_RS08710	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I4W80_RS08715	COG3209	COG3209 Rhs family protein
I4W80_RS08720	COG1366	Belongs to the anti-sigma-factor antagonist family
I4W80_RS08735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I4W80_RS08740	COG1388	LysM domain
I4W80_RS08745	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I4W80_RS08750	COG4224	UPF0291 protein
I4W80_RS08755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I4W80_RS08765	COG3763	UPF0154 protein
I4W80_RS08775	COG0785	Cytochrome C biogenesis protein
I4W80_RS08780	COG4846	Membrane protein involved in cytochrome C biogenesis
I4W80_RS08790	COG0071	Belongs to the small heat shock protein (HSP20) family
I4W80_RS08805	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I4W80_RS08810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4W80_RS08830	COG0824	Thioesterase
I4W80_RS08840	COG4841	protein insertion into membrane
I4W80_RS08845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I4W80_RS08850	COG1832	CoA-binding protein
I4W80_RS08855	COG0187	DNA topoisomerase II activity
I4W80_RS08860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I4W80_RS08870	COG0738	Major facilitator superfamily
I4W80_RS08875	COG0473	3-isopropylmalate dehydrogenase activity
I4W80_RS08880	COG0110	maltose O-acetyltransferase activity
I4W80_RS08885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I4W80_RS08890	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I4W80_RS08895	COG0640	Transcriptional regulator
I4W80_RS08905	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I4W80_RS08910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I4W80_RS08920	COG1309	transcriptional regulator
I4W80_RS08925	COG2249	NAD(P)H dehydrogenase (quinone) activity
I4W80_RS08930	COG1733	regulation of RNA biosynthetic process
I4W80_RS08935	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I4W80_RS08940	COG0251	oxidation-reduction process
I4W80_RS08965	COG0657	acetylesterase activity
I4W80_RS08975	COG2723	6-phospho-beta-galactosidase activity
I4W80_RS08980	COG1263	PTS System
I4W80_RS08980	COG2190	(PTS) system
I4W80_RS08980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_RS08995	COG2205	protein histidine kinase activity
I4W80_RS09000	COG0745	RESPONSE REGULATOR receiver
I4W80_RS09010	COG3507	Belongs to the glycosyl hydrolase 43 family
I4W80_RS09015	COG1012	belongs to the aldehyde dehydrogenase family
I4W80_RS09020	COG1486	melibiose metabolic process
I4W80_RS09025	COG0395	ABC-type sugar transport system, permease component
I4W80_RS09030	COG1175	transmembrane transport
I4W80_RS09035	COG1653	transport
I4W80_RS09040	COG1609	Transcriptional regulator
I4W80_RS09045	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I4W80_RS09060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_RS09070	COG0456	acetyltransferase
I4W80_RS09075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I4W80_RS09090	COG5444	nuclease activity
I4W80_RS09095	COG1846	Transcriptional regulator
I4W80_RS09100	COG2814	Major facilitator Superfamily
I4W80_RS09110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4W80_RS09110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_RS09110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4W80_RS09115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4W80_RS09115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4W80_RS09115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_RS09120	COG1105	Belongs to the carbohydrate kinase PfkB family
I4W80_RS09130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I4W80_RS09150	COG1012	belongs to the aldehyde dehydrogenase family
I4W80_RS09155	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I4W80_RS09160	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I4W80_RS09165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I4W80_RS09170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I4W80_RS09175	COG1024	Enoyl-CoA hydratase
I4W80_RS09180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I4W80_RS09185	COG0511	ligase activity, forming carbon-carbon bonds
I4W80_RS09190	COG0439	Biotin carboxylase
I4W80_RS09195	COG0318	PFAM AMP-dependent synthetase and ligase
I4W80_RS09200	COG1960	acyl-CoA dehydrogenase activity
I4W80_RS09205	COG1649	PFAM Uncharacterised BCR, COG1649
I4W80_RS09210	COG2365	Tyrosine phosphatase family
I4W80_RS09215	COG1349	DNA-binding transcription factor activity
I4W80_RS09220	COG1942	4-Oxalocrotonate Tautomerase
I4W80_RS09230	COG3835	regulator
I4W80_RS09235	COG0277	FAD linked oxidase domain protein
I4W80_RS09240	COG0247	lactate metabolic process
I4W80_RS09260	COG0166	Belongs to the GPI family
I4W80_RS09265	COG2246	polysaccharide biosynthetic process
I4W80_RS09270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I4W80_RS09275	COG0586	Pfam SNARE associated Golgi protein
I4W80_RS09280	COG1587	Uroporphyrinogen-III synthase
I4W80_RS09290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I4W80_RS09305	COG0534	Mate efflux family protein
I4W80_RS09310	COG2027	D-alanyl-D-alanine carboxypeptidase
I4W80_RS09315	COG4677	pectinesterase activity
I4W80_RS09320	COG2323	membrane
I4W80_RS09325	COG2146	nitrite reductase [NAD(P)H] activity
I4W80_RS09330	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I4W80_RS09335	COG0243	molybdopterin cofactor binding
I4W80_RS09340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I4W80_RS09345	COG2223	nitrite transmembrane transporter activity
I4W80_RS09350	COG0493	'glutamate synthase
I4W80_RS09355	COG0067	glutamate synthase
I4W80_RS09355	COG0070	glutamate synthase
I4W80_RS09355	COG0069	glutamate synthase activity
I4W80_RS09360	COG0583	DNA-binding transcription factor activity
I4W80_RS09370	COG1132	(ABC) transporter
I4W80_RS09375	COG4978	Transcriptional regulator
I4W80_RS09375	COG0789	Transcriptional regulator
I4W80_RS09380	COG0454	-acetyltransferase
I4W80_RS09385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I4W80_RS09390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I4W80_RS09395	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I4W80_RS09405	COG0243	molybdopterin cofactor binding
I4W80_RS09415	COG1070	Carbohydrate kinase
I4W80_RS09420	COG2115	Belongs to the xylose isomerase family
I4W80_RS09425	COG1940	carbohydrate kinase activity
I4W80_RS09435	COG2211	Major facilitator Superfamily
I4W80_RS09440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4W80_RS09445	COG1994	Peptidase M50
I4W80_RS09465	COG1309	transcriptional regulator
I4W80_RS09470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I4W80_RS09475	COG3708	Transcriptional regulator
I4W80_RS09480	COG2378	regulation of single-species biofilm formation
I4W80_RS09490	COG0640	Transcriptional regulator
I4W80_RS09495	COG0531	amino acid
I4W80_RS09500	COG0741	lytic transglycosylase activity
I4W80_RS09505	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I4W80_RS09510	COG2079	MmgE PrpD family protein
I4W80_RS09515	COG0372	Belongs to the citrate synthase family
I4W80_RS09520	COG2322	membrane
I4W80_RS09530	COG3584	3D domain protein
I4W80_RS09530	COG1388	LysM domain
I4W80_RS09535	COG0514	ATP-dependent DNA helicase (RecQ)
I4W80_RS09545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I4W80_RS09570	COG1012	belongs to the aldehyde dehydrogenase family
I4W80_RS09575	COG1657	PFAM Prenyltransferase squalene oxidase
I4W80_RS09580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I4W80_RS09585	COG0385	Bile acid
I4W80_RS09590	COG0508	dehydrogenase complex catalyzes the overall conversion of
I4W80_RS09595	COG0567	Dehydrogenase, E1 component
I4W80_RS09600	COG4548	von Willebrand factor, type A
I4W80_RS09605	COG0714	Associated with various cellular activities
I4W80_RS09610	COG2032	superoxide dismutase activity
I4W80_RS09615	COG0791	NLP P60 protein
I4W80_RS09615	COG1388	LysM domain
I4W80_RS09620	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I4W80_RS09625	COG0534	Mate efflux family protein
I4W80_RS09630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I4W80_RS09635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I4W80_RS09645	COG2962	Rard protein
I4W80_RS09660	COG1733	regulation of RNA biosynthetic process
I4W80_RS09665	COG0778	Nitroreductase
I4W80_RS09675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I4W80_RS09680	COG0793	Belongs to the peptidase S41A family
I4W80_RS09680	COG3409	Peptidoglycan-binding domain 1 protein
I4W80_RS09685	COG2226	methyltransferase
I4W80_RS09695	COG1876	peptidase activity
I4W80_RS09700	COG0813	purine-nucleoside phosphorylase activity
I4W80_RS09710	COG0671	phosphoesterase, PA-phosphatase related
I4W80_RS09730	COG4479	Belongs to the UPF0346 family
I4W80_RS09740	COG1509	lysine 2,3-aminomutase activity
I4W80_RS09745	COG3829	transcription factor binding
I4W80_RS09750	COG0463	Glycosyl transferase, family 2
I4W80_RS09765	COG4641	Protein conserved in bacteria
I4W80_RS09775	COG1086	Polysaccharide biosynthesis protein
I4W80_RS09780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I4W80_RS09785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I4W80_RS09790	COG1846	Transcriptional regulator
I4W80_RS09810	COG4698	Protein conserved in bacteria
I4W80_RS09815	COG2755	lipolytic protein G-D-S-L family
I4W80_RS09820	COG1999	signal sequence binding
I4W80_RS09835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I4W80_RS09840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I4W80_RS09845	COG1272	protein, Hemolysin III
I4W80_RS09850	COG0204	Acyl-transferase
I4W80_RS09855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I4W80_RS09860	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I4W80_RS09865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I4W80_RS09875	COG2136	Putative SAM-dependent methyltransferase
I4W80_RS09875	COG2521	methyltransferase
I4W80_RS09885	COG0129	dihydroxy-acid dehydratase activity
I4W80_RS09890	COG1413	lyase activity
I4W80_RS09895	COG1418	mRNA catabolic process
I4W80_RS09900	COG0386	Belongs to the glutathione peroxidase family
I4W80_RS09905	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I4W80_RS09910	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I4W80_RS09915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I4W80_RS09925	COG1278	Cold shock
I4W80_RS09940	COG0328	RNA-DNA hybrid ribonuclease activity
I4W80_RS09945	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I4W80_RS09950	COG0328	RNA-DNA hybrid ribonuclease activity
I4W80_RS09960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I4W80_RS09970	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I4W80_RS09980	COG1755	Isoprenylcysteine carboxyl methyltransferase
I4W80_RS09985	COG3424	synthase
I4W80_RS09990	COG0456	acetyltransferase
I4W80_RS09990	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I4W80_RS09995	COG0726	polysaccharide deacetylase
I4W80_RS10000	COG2233	PERMEase
I4W80_RS10005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I4W80_RS10010	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I4W80_RS10015	COG1199	ATP-dependent helicase activity
I4W80_RS10025	COG0116	Belongs to the methyltransferase superfamily
I4W80_RS10035	COG3599	regulation of cell shape
I4W80_RS10040	COG4474	Belongs to the UPF0398 family
I4W80_RS10050	COG3359	exonuclease
I4W80_RS10055	COG1205	dead DEAH box helicase
I4W80_RS10055	COG1111	helicase
I4W80_RS10060	COG1902	pentaerythritol trinitrate reductase activity
I4W80_RS10065	COG2190	(PTS) system
I4W80_RS10070	COG0071	Belongs to the small heat shock protein (HSP20) family
I4W80_RS10100	COG3331	DNA recombination
I4W80_RS10105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I4W80_RS10105	COG4499	WXG100 protein secretion system (Wss), protein YukC
I4W80_RS10115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I4W80_RS10120	COG3935	DnaD domain protein
I4W80_RS10125	COG0017	Asparaginyl-tRNA synthetase
I4W80_RS10130	COG5353	protein conserved in bacteria
I4W80_RS10140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I4W80_RS10140	COG1199	ATP-dependent helicase activity
I4W80_RS10145	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I4W80_RS10150	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I4W80_RS10155	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I4W80_RS10165	COG0617	tRNA 3'-terminal CCA addition
I4W80_RS10170	COG0438	transferase activity, transferring glycosyl groups
I4W80_RS10175	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I4W80_RS10180	COG1803	Methylglyoxal synthase
I4W80_RS10185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I4W80_RS10190	COG1694	Mazg nucleotide pyrophosphohydrolase
I4W80_RS10195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4W80_RS10205	COG4347	Protein of unknown function (DUF1405)
I4W80_RS10210	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I4W80_RS10210	COG2010	Cytochrome c
I4W80_RS10215	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I4W80_RS10220	COG0723	plastoquinol--plastocyanin reductase activity
I4W80_RS10230	COG5582	Belongs to the UPF0302 family
I4W80_RS10235	COG0457	Tetratricopeptide repeat
I4W80_RS10240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I4W80_RS10245	COG0287	Prephenate dehydrogenase
I4W80_RS10250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I4W80_RS10255	COG0159	tryptophan synthase activity
I4W80_RS10260	COG0133	tryptophan synthase activity
I4W80_RS10265	COG0135	phosphoribosylanthranilate isomerase activity
I4W80_RS10270	COG0134	indole-3-glycerol-phosphate synthase activity
I4W80_RS10275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I4W80_RS10285	COG4401	Chorismate mutase type I
I4W80_RS10290	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I4W80_RS10295	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I4W80_RS10300	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I4W80_RS10305	COG0105	UTP biosynthetic process
I4W80_RS10310	COG0142	geranyltranstransferase activity
I4W80_RS10315	COG2226	methyltransferase
I4W80_RS10320	COG0142	geranyltranstransferase activity
I4W80_RS10330	COG0302	gtp cyclohydrolase
I4W80_RS10335	COG0776	regulation of translation
I4W80_RS10340	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I4W80_RS10355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I4W80_RS10360	COG1160	GTP binding
I4W80_RS10385	COG1304	FMN binding
I4W80_RS10390	COG0539	negative regulation of cytoplasmic translation
I4W80_RS10395	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I4W80_RS10405	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I4W80_RS10410	COG2959	enzyme of heme biosynthesis
I4W80_RS10415	COG3773	Cell wall hydrolase
I4W80_RS10415	COG3409	Peptidoglycan-binding domain 1 protein
I4W80_RS10420	COG2339	peptidase activity
I4W80_RS10425	COG0492	ferredoxin-NADP+ reductase activity
I4W80_RS10430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I4W80_RS10435	COG4862	establishment of competence for transformation
I4W80_RS10440	COG1408	metallophosphoesterase
I4W80_RS10450	COG1388	LysM domain
I4W80_RS10455	COG1266	CAAX protease self-immunity
I4W80_RS10460	COG0514	ATP-dependent DNA helicase (RecQ)
I4W80_RS10465	COG4955	Helix-turn-helix domain
I4W80_RS10470	COG1141	Ferredoxin
I4W80_RS10475	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I4W80_RS10480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I4W80_RS10495	COG1595	DNA-templated transcription, initiation
I4W80_RS10500	COG5002	protein histidine kinase activity
I4W80_RS10505	COG0745	RESPONSE REGULATOR receiver
I4W80_RS10510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I4W80_RS10515	COG1333	cytochrome c biogenesis protein
I4W80_RS10520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4W80_RS10525	COG1187	pseudouridine synthase activity
I4W80_RS10530	COG0700	Nucleoside recognition
I4W80_RS10535	COG2715	membrane protein required for spore maturation
I4W80_RS10540	COG1686	Belongs to the peptidase S11 family
I4W80_RS10550	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I4W80_RS10555	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I4W80_RS10565	COG1547	Domain of unknown function (DUF309)
I4W80_RS10570	COG0456	acetyltransferase
I4W80_RS10575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I4W80_RS10580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I4W80_RS10580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I4W80_RS10585	COG0307	riboflavin synthase, alpha
I4W80_RS10605	COG2814	Major facilitator Superfamily
I4W80_RS10610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I4W80_RS10615	COG4086	secreted protein
I4W80_RS10620	COG0019	diaminopimelate decarboxylase activity
I4W80_RS10625	COG0697	spore germination
I4W80_RS10640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I4W80_RS10660	COG1191	sigma factor activity
I4W80_RS10665	COG2172	sigma factor antagonist activity
I4W80_RS10675	COG1686	Belongs to the peptidase S11 family
I4W80_RS10680	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I4W80_RS10685	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I4W80_RS10690	COG4974	Belongs to the 'phage' integrase family
I4W80_RS10700	COG0735	belongs to the Fur family
I4W80_RS10705	COG1300	Membrane
I4W80_RS10710	COG1404	Belongs to the peptidase S8 family
I4W80_RS10720	COG2153	protein acetylation
I4W80_RS10725	COG1379	DNA repair
I4W80_RS10730	COG0494	nUDIX hydrolase
I4W80_RS10735	COG0667	Aldo Keto reductase
I4W80_RS10745	COG1073	alpha beta
I4W80_RS10750	COG0457	Tetratricopeptide repeat
I4W80_RS10760	COG4918	Iron-sulphur cluster biosynthesis
I4W80_RS10765	COG4305	rare lipoprotein A
I4W80_RS10770	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I4W80_RS10770	COG0456	acetyltransferase
I4W80_RS10775	COG0456	acetyltransferase
I4W80_RS10785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I4W80_RS10795	COG2211	Major facilitator Superfamily
I4W80_RS10800	COG1072	(Pantothenic acid kinase))
I4W80_RS10805	COG0446	pyridine nucleotide-disulphide oxidoreductase
I4W80_RS10815	COG0300	oxidoreductase activity
I4W80_RS10820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I4W80_RS10825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I4W80_RS10835	COG4187	Peptidase family M20/M25/M40
I4W80_RS10840	COG1902	pentaerythritol trinitrate reductase activity
I4W80_RS10845	COG0596	Alpha beta hydrolase
I4W80_RS10850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I4W80_RS10860	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I4W80_RS10865	COG2188	Transcriptional regulator
I4W80_RS10870	COG2723	6-phospho-beta-galactosidase activity
I4W80_RS10875	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4W80_RS10880	COG1447	Phosphotransferase system cellobiose-specific component IIA
I4W80_RS10885	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4W80_RS10895	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS10905	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I4W80_RS10910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I4W80_RS10920	COG0706	membrane insertase activity
I4W80_RS10925	COG0835	chemotaxis
I4W80_RS10930	COG2195	Cleaves the N-terminal amino acid of tripeptides
I4W80_RS10935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I4W80_RS10940	COG0346	lactoylglutathione lyase activity
I4W80_RS10950	COG1376	ErfK ybiS ycfS ynhG family protein
I4W80_RS10955	COG4129	membrane
I4W80_RS10960	COG1126	abc transporter atp-binding protein
I4W80_RS10965	COG0765	amino acid transport
I4W80_RS10970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4W80_RS10980	COG1597	lipid kinase activity
I4W80_RS10990	COG0508	dehydrogenase complex catalyzes the overall conversion of
I4W80_RS10995	COG0022	dehydrogenase e1 component
I4W80_RS11000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I4W80_RS11005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I4W80_RS11010	COG3426	butyrate kinase activity
I4W80_RS11015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I4W80_RS11020	COG0280	phosphate acetyltransferase
I4W80_RS11025	COG3290	protein histidine kinase activity
I4W80_RS11025	COG3829	transcription factor binding
I4W80_RS11035	COG0584	glycerophosphoryl diester phosphodiesterase
I4W80_RS11040	COG0457	Tetratricopeptide repeat
I4W80_RS11045	COG0745	RESPONSE REGULATOR receiver
I4W80_RS11050	COG0750	zinc metalloprotease
I4W80_RS11055	COG0497	DNA recombination
I4W80_RS11060	COG1438	arginine binding
I4W80_RS11065	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I4W80_RS11070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I4W80_RS11075	COG0142	geranyltranstransferase activity
I4W80_RS11080	COG1722	exodeoxyribonuclease VII activity
I4W80_RS11085	COG1570	exodeoxyribonuclease VII activity
I4W80_RS11090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I4W80_RS11095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I4W80_RS11100	COG1302	Protein conserved in bacteria
I4W80_RS11105	COG0439	Biotin carboxylase
I4W80_RS11110	COG0511	ligase activity, forming carbon-carbon bonds
I4W80_RS11150	COG3854	ATPases associated with a variety of cellular activities
I4W80_RS11160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I4W80_RS11165	COG0006	proline dipeptidase activity
I4W80_RS11170	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I4W80_RS11180	COG3872	metal-dependent enzyme
I4W80_RS11190	COG1752	Esterase of the alpha-beta hydrolase superfamily
I4W80_RS11195	COG1321	iron dependent repressor
I4W80_RS11200	COG0095	Lipoate-protein ligase
I4W80_RS11205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I4W80_RS11210	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I4W80_RS11215	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I4W80_RS11220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I4W80_RS11225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I4W80_RS11250	COG0681	Belongs to the peptidase S26 family
I4W80_RS11285	COG4970	Tfp pilus assembly protein FimT
I4W80_RS11290	COG4537	Required for transformation and DNA binding
I4W80_RS11295	COG1459	type II secretion system
I4W80_RS11300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I4W80_RS11305	COG1366	Belongs to the anti-sigma-factor antagonist family
I4W80_RS11315	COG1393	Belongs to the ArsC family
I4W80_RS11325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I4W80_RS11335	COG0011	TIGRFAM Protein of
I4W80_RS11340	COG2814	Major facilitator Superfamily
I4W80_RS11345	COG2866	Carboxypeptidase
I4W80_RS11350	COG1368	sulfuric ester hydrolase activity
I4W80_RS11355	COG1940	carbohydrate kinase activity
I4W80_RS11360	COG4483	Protein conserved in bacteria
I4W80_RS11365	COG0457	Tetratricopeptide repeat
I4W80_RS11365	COG0705	Rhomboid family
I4W80_RS11380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I4W80_RS11385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I4W80_RS11395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I4W80_RS11400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I4W80_RS11405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I4W80_RS11410	COG0581	inorganic phosphate transmembrane transporter activity
I4W80_RS11415	COG0573	inorganic phosphate transmembrane transporter activity
I4W80_RS11420	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I4W80_RS11425	COG0768	penicillin binding
I4W80_RS11430	COG0477	Major facilitator Superfamily
I4W80_RS11435	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I4W80_RS11440	COG2839	Protein conserved in bacteria
I4W80_RS11445	COG5521	maltodextrose utilization protein MalA
I4W80_RS11450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I4W80_RS11455	COG1388	LysM domain
I4W80_RS11460	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I4W80_RS11465	COG4709	membrane
I4W80_RS11470	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I4W80_RS11475	COG1940	carbohydrate kinase activity
I4W80_RS11480	COG0735	belongs to the Fur family
I4W80_RS11485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I4W80_RS11490	COG1121	(ABC) transporter
I4W80_RS11495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4W80_RS11510	COG0513	Belongs to the DEAD box helicase family
I4W80_RS11520	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I4W80_RS11525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I4W80_RS11530	COG2384	SAM-dependent methyltransferase
I4W80_RS11535	COG2010	Cytochrome c
I4W80_RS11540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I4W80_RS11545	COG0358	DNA primase activity
I4W80_RS11550	COG1671	Belongs to the UPF0178 family
I4W80_RS11555	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I4W80_RS11560	COG0517	IMP dehydrogenase activity
I4W80_RS11565	COG0751	glycine-tRNA ligase activity
I4W80_RS11570	COG0752	glycyl-tRNA synthetase alpha subunit
I4W80_RS11575	COG1381	Involved in DNA repair and RecF pathway recombination
I4W80_RS11585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I4W80_RS11590	COG0295	cytidine deaminase activity
I4W80_RS11595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I4W80_RS11600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I4W80_RS11605	COG1480	7TM receptor with intracellular HD hydrolase
I4W80_RS11610	COG1702	phosphate starvation-inducible protein PhoH
I4W80_RS11615	COG0561	phosphatase activity
I4W80_RS11630	COG4864	UPF0365 protein
I4W80_RS11635	COG1030	water channel activity
I4W80_RS11640	COG1610	YqeY-like protein
I4W80_RS11650	COG1283	sodium-dependent phosphate transmembrane transporter activity
I4W80_RS11655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I4W80_RS11660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I4W80_RS11665	COG2264	protein methyltransferase activity
I4W80_RS11670	COG0484	heat shock protein binding
I4W80_RS11675	COG0443	Heat shock 70 kDa protein
I4W80_RS11680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I4W80_RS11685	COG1420	regulation of RNA biosynthetic process
I4W80_RS11690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I4W80_RS11695	COG0481	GTPase activity
I4W80_RS11705	COG0860	N-Acetylmuramoyl-L-alanine amidase
I4W80_RS11710	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I4W80_RS11715	COG0268	Binds directly to 16S ribosomal RNA
I4W80_RS11720	COG1466	dna polymerase III delta subunit
I4W80_RS11730	COG0658	competence protein
I4W80_RS11730	COG2333	competence protein COMEC
I4W80_RS11735	COG2131	deaminase
I4W80_RS11740	COG1555	photosystem II stabilization
I4W80_RS11740	COG1596	polysaccharide export
I4W80_RS11745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I4W80_RS11750	COG2226	methyltransferase
I4W80_RS11755	COG0799	negative regulation of ribosome biogenesis
I4W80_RS11760	COG1713	HD superfamily hydrolase involved in NAD metabolism
I4W80_RS11765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I4W80_RS11770	COG1534	Rna-binding protein
I4W80_RS11775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I4W80_RS11780	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I4W80_RS11785	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I4W80_RS11800	COG2755	lipolytic protein G-D-S-L family
I4W80_RS11810	COG0457	Tetratricopeptide repeat
I4W80_RS11825	COG2186	Transcriptional regulator
I4W80_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS11845	COG3958	Transketolase
I4W80_RS11850	COG3959	Transketolase, thiamine diphosphate binding domain
I4W80_RS11870	COG0726	polysaccharide deacetylase
I4W80_RS11905	COG1122	ATPase activity
I4W80_RS11930	COG2160	L-arabinose isomerase activity
I4W80_RS11945	COG1609	Transcriptional regulator
I4W80_RS11955	COG1846	Transcriptional regulator
I4W80_RS11965	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I4W80_RS11970	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I4W80_RS11975	COG1733	regulation of RNA biosynthetic process
I4W80_RS11980	COG0657	acetylesterase activity
I4W80_RS12040	COG2602	Beta-lactamase
I4W80_RS12045	COG1960	acyl-CoA dehydrogenase activity
I4W80_RS12050	COG1126	abc transporter atp-binding protein
I4W80_RS12055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4W80_RS12060	COG0765	amino acid transport
I4W80_RS12070	COG3546	catalase activity
I4W80_RS12075	COG1063	alcohol dehydrogenase
I4W80_RS12085	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS12095	COG1115	amino acid carrier protein
I4W80_RS12100	COG0583	DNA-binding transcription factor activity
I4W80_RS12105	COG1063	alcohol dehydrogenase
I4W80_RS12110	COG2226	methyltransferase
I4W80_RS12135	COG0626	cystathionine gamma-synthase activity
I4W80_RS12140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I4W80_RS12145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I4W80_RS12150	COG2226	methyltransferase
I4W80_RS12165	COG0768	penicillin binding
I4W80_RS12170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I4W80_RS12175	COG0572	uridine kinase
I4W80_RS12180	COG0826	peptidase U32
I4W80_RS12185	COG0826	peptidase U32
I4W80_RS12190	COG4122	O-methyltransferase activity
I4W80_RS12195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I4W80_RS12200	COG0183	Belongs to the thiolase family
I4W80_RS12205	COG0318	PFAM AMP-dependent synthetase and ligase
I4W80_RS12210	COG1268	BioY protein
I4W80_RS12215	COG3906	Belongs to the UPF0473 family
I4W80_RS12220	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I4W80_RS12225	COG4472	Bacterial protein of unknown function (DUF965)
I4W80_RS12230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I4W80_RS12235	COG0628	permease
I4W80_RS12240	COG1126	abc transporter atp-binding protein
I4W80_RS12245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4W80_RS12250	COG0765	amino acid transport
I4W80_RS12255	COG0765	amino acid transport
I4W80_RS12270	COG3881	PFAM PRC-barrel domain
I4W80_RS12275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I4W80_RS12280	COG0457	Tetratricopeptide repeat
I4W80_RS12285	COG0482	sulfurtransferase activity
I4W80_RS12290	COG1104	cysteine desulfurase activity
I4W80_RS12295	COG1959	2 iron, 2 sulfur cluster binding
I4W80_RS12300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I4W80_RS12305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I4W80_RS12320	COG0124	histidyl-tRNA synthetase
I4W80_RS12330	COG4991	sh3 domain protein
I4W80_RS12330	COG0860	N-Acetylmuramoyl-L-alanine amidase
I4W80_RS12330	COG3103	Sh3 type 3 domain protein
I4W80_RS12335	COG1490	D-aminoacyl-tRNA deacylase activity
I4W80_RS12340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I4W80_RS12345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I4W80_RS12350	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I4W80_RS12350	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I4W80_RS12355	COG5416	Lipopolysaccharide assembly protein A domain
I4W80_RS12360	COG0490	domain, Protein
I4W80_RS12365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I4W80_RS12365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I4W80_RS12375	COG2244	polysaccharide biosynthetic process
I4W80_RS12380	COG2323	membrane
I4W80_RS12390	COG1862	Preprotein translocase
I4W80_RS12395	COG0343	queuine tRNA-ribosyltransferase activity
I4W80_RS12400	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I4W80_RS12410	COG2255	four-way junction helicase activity
I4W80_RS12415	COG0632	four-way junction helicase activity
I4W80_RS12425	COG2112	serine threonine protein kinase
I4W80_RS12440	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I4W80_RS12455	COG1388	LysM domain
I4W80_RS12460	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I4W80_RS12465	COG0157	Belongs to the NadC ModD family
I4W80_RS12470	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I4W80_RS12475	COG1104	cysteine desulfurase activity
I4W80_RS12480	COG1827	regulation of RNA biosynthetic process
I4W80_RS12485	COG0077	Prephenate dehydratase
I4W80_RS12490	COG4492	Belongs to the UPF0735 family
I4W80_RS12495	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I4W80_RS12500	COG3290	protein histidine kinase activity
I4W80_RS12505	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I4W80_RS12510	COG2868	ribosomal protein
I4W80_RS12515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I4W80_RS12520	COG1994	Peptidase M50
I4W80_RS12525	COG0739	heme binding
I4W80_RS12530	COG2894	cell division
I4W80_RS12535	COG0850	regulation of cytokinetic process
I4W80_RS12540	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I4W80_RS12550	COG1077	Cell shape determining protein MreB Mrl
I4W80_RS12555	COG2003	Belongs to the UPF0758 family
I4W80_RS12560	COG0424	maF-like protein
I4W80_RS12570	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I4W80_RS12575	COG0285	dihydrofolate synthase activity
I4W80_RS12580	COG0525	valine-tRNA ligase activity
I4W80_RS12590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I4W80_RS12595	COG1388	LysM domain
I4W80_RS12600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I4W80_RS12605	COG0113	porphobilinogen synthase activity
I4W80_RS12610	COG1587	Uroporphyrinogen-III synthase
I4W80_RS12615	COG0181	hydroxymethylbilane synthase activity
I4W80_RS12620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I4W80_RS12625	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I4W80_RS12635	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I4W80_RS12640	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I4W80_RS12645	COG0470	DNA polymerase III
I4W80_RS12645	COG1067	ATP-dependent peptidase activity
I4W80_RS12650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I4W80_RS12655	COG0544	peptidyl-prolyl cis-trans isomerase activity
I4W80_RS12660	COG0457	Tetratricopeptide repeat
I4W80_RS12660	COG1477	protein flavinylation
I4W80_RS12665	COG0066	3-isopropylmalate dehydratase activity
I4W80_RS12670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I4W80_RS12675	COG0473	3-isopropylmalate dehydrogenase activity
I4W80_RS12680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I4W80_RS12685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I4W80_RS12690	COG0440	acetolactate synthase activity
I4W80_RS12695	COG0028	Belongs to the TPP enzyme family
I4W80_RS12700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I4W80_RS12705	COG2706	6-phosphogluconolactonase activity
I4W80_RS12710	COG3339	Conserved Protein
I4W80_RS12715	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I4W80_RS12720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I4W80_RS12725	COG1696	Membrane protein involved in D-alanine export
I4W80_RS12730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I4W80_RS12765	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I4W80_RS12775	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS12795	COG0622	Phosphoesterase
I4W80_RS12800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I4W80_RS12805	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I4W80_RS12810	COG5401	PFAM Sporulation and spore germination
I4W80_RS12815	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I4W80_RS12820	COG1846	Transcriptional regulator
I4W80_RS12825	COG2197	response regulator
I4W80_RS12850	COG0860	N-Acetylmuramoyl-L-alanine amidase
I4W80_RS12855	COG4824	toxin secretion phage lysis holin
I4W80_RS12880	COG3942	CHAP domain
I4W80_RS12880	COG1705	Flagellar rod assembly protein muramidase FlgJ
I4W80_RS12890	COG3953	SLT domain
I4W80_RS12890	COG5412	phage tail tape measure protein
I4W80_RS12955	COG1802	Transcriptional regulator
I4W80_RS12955	COG4626	Terminase
I4W80_RS12990	COG0582	viral genome integration into host DNA
I4W80_RS12995	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I4W80_RS13080	COG2197	response regulator
I4W80_RS13085	COG2851	Citrate transporter
I4W80_RS13090	COG0583	DNA-binding transcription factor activity
I4W80_RS13095	COG2828	Protein conserved in bacteria
I4W80_RS13105	COG0824	Thioesterase
I4W80_RS13110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I4W80_RS13115	COG1053	succinate dehydrogenase
I4W80_RS13120	COG2009	succinate dehydrogenase
I4W80_RS13125	COG1719	4-vinyl reductase, 4VR
I4W80_RS13130	COG0527	aspartate kinase activity
I4W80_RS13135	COG0322	excinuclease ABC activity
I4W80_RS13140	COG3118	belongs to the thioredoxin family
I4W80_RS13145	COG3534	alpha-L-arabinofuranosidase
I4W80_RS13150	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I4W80_RS13155	COG2086	electron transfer activity
I4W80_RS13160	COG1024	Enoyl-CoA hydratase
I4W80_RS13165	COG1309	transcriptional regulator
I4W80_RS13170	COG0318	PFAM AMP-dependent synthetase and ligase
I4W80_RS13180	COG3766	membrane
I4W80_RS13185	COG1193	negative regulation of DNA recombination
I4W80_RS13190	COG1796	DNA polymerase
I4W80_RS13190	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I4W80_RS13195	COG1286	toxin biosynthetic process
I4W80_RS13200	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I4W80_RS13205	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I4W80_RS13210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4W80_RS13210	COG0072	phenylalanine-tRNA ligase activity
I4W80_RS13215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I4W80_RS13220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I4W80_RS13230	COG1966	Carbon starvation protein
I4W80_RS13235	COG1363	Peptidase, m42
I4W80_RS13245	COG3326	Membrane
I4W80_RS13250	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I4W80_RS13255	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I4W80_RS13260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I4W80_RS13270	COG1011	Hydrolase
I4W80_RS13280	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I4W80_RS13290	COG0398	Pfam SNARE associated Golgi protein
I4W80_RS13295	COG1484	DNA-dependent DNA replication
I4W80_RS13300	COG3611	Membrane attachment protein
I4W80_RS13305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I4W80_RS13315	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I4W80_RS13320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I4W80_RS13325	COG0237	dephospho-CoA kinase activity
I4W80_RS13330	COG1971	Probably functions as a manganese efflux pump
I4W80_RS13335	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I4W80_RS13340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I4W80_RS13340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I4W80_RS13345	COG5002	protein histidine kinase activity
I4W80_RS13350	COG0745	RESPONSE REGULATOR receiver
I4W80_RS13355	COG0039	L-malate dehydrogenase activity
I4W80_RS13360	COG0538	isocitrate dehydrogenase activity
I4W80_RS13365	COG0372	Belongs to the citrate synthase family
I4W80_RS13370	COG2707	UPF0756 membrane protein
I4W80_RS13375	COG0628	permease
I4W80_RS13380	COG3030	protein affecting phage T7 exclusion by the F plasmid
I4W80_RS13390	COG0205	6-phosphofructokinase activity
I4W80_RS13395	COG0825	malonyl-CoA metabolic process
I4W80_RS13400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I4W80_RS13405	COG0281	malic enzyme
I4W80_RS13410	COG0587	DNA-directed DNA polymerase activity
I4W80_RS13430	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I4W80_RS13440	COG4109	DRTGG domain
I4W80_RS13445	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I4W80_RS13450	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS13460	COG0165	Argininosuccinate lyase
I4W80_RS13465	COG0137	argininosuccinate synthase activity
I4W80_RS13470	COG0521	Mo-molybdopterin cofactor biosynthetic process
I4W80_RS13475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I4W80_RS13480	COG0827	DNA restriction-modification system
I4W80_RS13485	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I4W80_RS13490	COG3874	Sporulation protein YtfJ
I4W80_RS13500	COG1714	RDD family
I4W80_RS13505	COG0616	signal peptide processing
I4W80_RS13510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I4W80_RS13520	COG3239	Fatty acid desaturase
I4W80_RS13525	COG4585	Histidine kinase
I4W80_RS13530	COG2197	response regulator
I4W80_RS13535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I4W80_RS13540	COG0745	RESPONSE REGULATOR receiver
I4W80_RS13545	COG2205	protein histidine kinase activity
I4W80_RS13550	COG0772	Belongs to the SEDS family
I4W80_RS13555	COG1695	Transcriptional regulator
I4W80_RS13560	COG1136	(ABC) transporter
I4W80_RS13565	COG0577	efflux transmembrane transporter activity
I4W80_RS13570	COG0402	S-adenosylhomocysteine deaminase activity
I4W80_RS13575	COG2249	NAD(P)H dehydrogenase (quinone) activity
I4W80_RS13590	COG1279	arginine transmembrane transporter activity
I4W80_RS13595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I4W80_RS13605	COG0301	tRNA thio-modification
I4W80_RS13610	COG1104	cysteine desulfurase activity
I4W80_RS13615	COG1114	Component of the transport system for branched-chain amino acids
I4W80_RS13620	COG1114	Component of the transport system for branched-chain amino acids
I4W80_RS13625	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I4W80_RS13630	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I4W80_RS13635	COG1309	transcriptional regulator
I4W80_RS13640	COG1956	GAF domain-containing protein
I4W80_RS13645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I4W80_RS13655	COG1335	isochorismatase
I4W80_RS13665	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I4W80_RS13670	COG2329	Antibiotic biosynthesis monooxygenase
I4W80_RS13675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I4W80_RS13680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I4W80_RS13685	COG0454	-acetyltransferase
I4W80_RS13690	COG0517	IMP dehydrogenase activity
I4W80_RS13695	COG0123	including yeast histone deacetylase and acetoin utilization protein
I4W80_RS13700	COG1609	Transcriptional regulator
I4W80_RS13705	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I4W80_RS13705	COG1605	Chorismate mutase
I4W80_RS13710	COG3118	belongs to the thioredoxin family
I4W80_RS13715	COG4980	gas vesicle protein
I4W80_RS13720	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I4W80_RS13725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I4W80_RS13730	COG1674	ftsk spoiiie
I4W80_RS13735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4W80_RS13740	COG4848	Belongs to the UPF0354 family
I4W80_RS13745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4W80_RS13760	COG1363	Peptidase, m42
I4W80_RS13765	COG5584	Small secreted protein
I4W80_RS13770	COG0281	malic enzyme
I4W80_RS13775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I4W80_RS13780	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I4W80_RS13790	COG0510	thiamine kinase activity
I4W80_RS13795	COG1597	lipid kinase activity
I4W80_RS13805	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I4W80_RS13810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I4W80_RS13815	COG3340	Belongs to the peptidase S51 family
I4W80_RS13820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I4W80_RS13825	COG2252	PERMEase
I4W80_RS13830	COG1349	DNA-binding transcription factor activity
I4W80_RS13835	COG1187	pseudouridine synthase activity
I4W80_RS13840	COG2244	polysaccharide biosynthetic process
I4W80_RS13845	COG2081	HI0933 family
I4W80_RS13855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I4W80_RS13860	COG3196	Protein conserved in bacteria
I4W80_RS13870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I4W80_RS13875	COG5578	integral membrane protein
I4W80_RS13880	COG0673	inositol 2-dehydrogenase activity
I4W80_RS13885	COG1653	transport
I4W80_RS13890	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I4W80_RS13895	COG4209	transmembrane transport
I4W80_RS13900	COG2207	Transcriptional regulator
I4W80_RS13905	COG1733	regulation of RNA biosynthetic process
I4W80_RS13910	COG2814	Major facilitator Superfamily
I4W80_RS13915	COG0656	L-ascorbic acid biosynthetic process
I4W80_RS13920	COG1653	transport
I4W80_RS13925	COG0395	ABC-type sugar transport system, permease component
I4W80_RS13930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I4W80_RS13935	COG1073	alpha beta
I4W80_RS13940	COG0495	leucyl-tRNA aminoacylation
I4W80_RS13950	COG2202	Pas domain
I4W80_RS13950	COG1366	Belongs to the anti-sigma-factor antagonist family
I4W80_RS13955	COG2433	Pfam Transposase IS66
I4W80_RS13960	COG0577	efflux transmembrane transporter activity
I4W80_RS13965	COG1136	(ABC) transporter
I4W80_RS13975	COG1131	(ABC) transporter
I4W80_RS13980	COG1725	Transcriptional regulator
I4W80_RS14000	COG1242	4 iron, 4 sulfur cluster binding
I4W80_RS14005	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I4W80_RS14010	COG4326	sporulation control protein
I4W80_RS14020	COG2267	carboxylic ester hydrolase activity
I4W80_RS14025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I4W80_RS14030	COG0367	asparagine synthase
I4W80_RS14035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I4W80_RS14040	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I4W80_RS14050	COG1506	peptidase
I4W80_RS14055	COG1233	COG1233 Phytoene dehydrogenase and related
I4W80_RS14075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I4W80_RS14080	COG1116	anion transmembrane transporter activity
I4W80_RS14085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I4W80_RS14090	COG0494	nUDIX hydrolase
I4W80_RS14095	COG2310	stress, protein
I4W80_RS14110	COG4824	toxin secretion phage lysis holin
I4W80_RS14120	COG0783	Belongs to the Dps family
I4W80_RS14135	COG1854	S-ribosylhomocysteine lyase activity
I4W80_RS14140	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I4W80_RS14145	COG0288	reversible hydration of carbon dioxide
I4W80_RS14150	COG0803	Belongs to the bacterial solute-binding protein 9 family
I4W80_RS14150	COG3443	Belongs to the bacterial solute-binding protein 9 family
I4W80_RS14160	COG1271	oxidase subunit
I4W80_RS14165	COG1294	oxidase, subunit
I4W80_RS14180	COG4948	Mandelate Racemase Muconate Lactonizing
I4W80_RS14185	COG0318	PFAM AMP-dependent synthetase and ligase
I4W80_RS14190	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I4W80_RS14195	COG0596	Alpha beta hydrolase
I4W80_RS14200	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I4W80_RS14205	COG1169	isochorismate synthase
I4W80_RS14210	COG1575	Belongs to the MenA family. Type 1 subfamily
I4W80_RS14215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I4W80_RS14345	COG3859	Proton-coupled thiamine transporter YuaJ
I4W80_RS14350	COG1247	-acetyltransferase
I4W80_RS14355	COG3339	Conserved Protein
I4W80_RS14360	COG0772	Belongs to the SEDS family
I4W80_RS14365	COG0772	Belongs to the SEDS family
I4W80_RS14370	COG2268	Band 7 protein
I4W80_RS14375	COG1585	Membrane protein implicated in regulation of membrane protease activity
I4W80_RS14380	COG2318	DinB family
I4W80_RS14385	COG1454	alcohol dehydrogenase
I4W80_RS14390	COG1012	belongs to the aldehyde dehydrogenase family
I4W80_RS14395	COG1510	regulation of RNA biosynthetic process
I4W80_RS14410	COG3409	Peptidoglycan-binding domain 1 protein
I4W80_RS14410	COG5632	N-Acetylmuramoyl-L-alanine amidase
I4W80_RS14465	COG3778	Protein conserved in bacteria
I4W80_RS14470	COG3299	homolog of phage Mu protein gp47
I4W80_RS14475	COG3628	GPW Gp25 family protein
I4W80_RS14485	COG4193	domain, Protein
I4W80_RS14490	COG1652	LysM domain
I4W80_RS14495	COG3953	SLT domain
I4W80_RS14495	COG5280	Phage tail tape measure protein TP901
I4W80_RS14495	COG3953	SLT domain
I4W80_RS14495	COG5280	Phage tail tape measure protein TP901
I4W80_RS14550	COG4653	Phage capsid family
I4W80_RS14555	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I4W80_RS14560	COG5518	Phage portal protein
I4W80_RS14565	COG1783	phage Terminase large subunit
I4W80_RS14570	COG5484	DNA packaging
I4W80_RS14575	COG1595	DNA-templated transcription, initiation
I4W80_RS14585	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I4W80_RS14605	COG1396	sequence-specific DNA binding
I4W80_RS14615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I4W80_RS14630	COG0628	permease
I4W80_RS14640	COG0673	inositol 2-dehydrogenase activity
I4W80_RS14645	COG0693	protein deglycase activity
I4W80_RS14650	COG0840	transmembrane signaling receptor activity
I4W80_RS14655	COG0840	transmembrane signaling receptor activity
I4W80_RS14660	COG0840	transmembrane signaling receptor activity
I4W80_RS14665	COG0840	transmembrane signaling receptor activity
I4W80_RS14680	COG2070	2-Nitropropane dioxygenase
I4W80_RS14685	COG0432	Pfam Uncharacterised protein family UPF0047
I4W80_RS14690	COG1253	flavin adenine dinucleotide binding
I4W80_RS14695	COG2738	Putative neutral zinc metallopeptidase
I4W80_RS14705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I4W80_RS14720	COG0166	Belongs to the GPI family
I4W80_RS14725	COG1979	alcohol dehydrogenase
I4W80_RS14730	COG1979	alcohol dehydrogenase
I4W80_RS14735	COG2155	Conserved Protein
I4W80_RS14740	COG1098	S1 RNA binding domain
I4W80_RS14745	COG0436	Aminotransferase
I4W80_RS14750	COG1522	sequence-specific DNA binding
I4W80_RS14755	COG2267	carboxylic ester hydrolase activity
I4W80_RS14765	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I4W80_RS14770	COG2205	protein histidine kinase activity
I4W80_RS14785	COG5018	Exonuclease
I4W80_RS14790	COG2814	Major facilitator Superfamily
I4W80_RS14795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I4W80_RS14800	COG3011	Protein conserved in bacteria
I4W80_RS14810	COG3290	protein histidine kinase activity
I4W80_RS14815	COG4565	transcriptional regulatory protein
I4W80_RS14820	COG1744	ABC transporter substrate-binding protein PnrA-like
I4W80_RS14825	COG3845	ABC transporter
I4W80_RS14830	COG4603	Belongs to the binding-protein-dependent transport system permease family
I4W80_RS14835	COG1079	Belongs to the binding-protein-dependent transport system permease family
I4W80_RS14840	COG3493	citrate carrier protein
I4W80_RS14850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I4W80_RS14850	COG2111	Na H antiporter
I4W80_RS14855	COG2111	Na H antiporter
I4W80_RS14860	COG1006	Multisubunit Na H antiporter MnhC subunit
I4W80_RS14865	COG0651	ATP synthesis coupled electron transport
I4W80_RS14870	COG1863	multisubunit Na H antiporter MnhE subunit
I4W80_RS14875	COG2212	antiporter activity
I4W80_RS14880	COG1320	monovalent cation:proton antiporter activity
I4W80_RS14885	COG2050	protein possibly involved in aromatic compounds catabolism
I4W80_RS14890	COG2197	response regulator
I4W80_RS14895	COG4585	Histidine kinase
I4W80_RS14905	COG0142	geranyltranstransferase activity
I4W80_RS14920	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I4W80_RS14925	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I4W80_RS14930	COG1335	isochorismatase
I4W80_RS14935	COG5506	Protein of unknown function (DUF1694)
I4W80_RS14955	COG0628	permease
I4W80_RS14970	COG1418	mRNA catabolic process
I4W80_RS14975	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS14985	COG1511	domain protein
I4W80_RS14990	COG1674	ftsk spoiiie
I4W80_RS14990	COG0433	COG0433 Predicted ATPase
I4W80_RS14995	COG4499	WXG100 protein secretion system (Wss), protein YukC
I4W80_RS15000	COG5417	Belongs to the EsaB family
I4W80_RS15005	COG4842	Belongs to the WXG100 family
I4W80_RS15010	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I4W80_RS15010	COG2508	Transcriptional regulator
I4W80_RS15015	COG0686	Belongs to the AlaDH PNT family
I4W80_RS15020	COG1268	BioY protein
I4W80_RS15025	COG2056	Na+-H+ antiporter family
I4W80_RS15030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I4W80_RS15035	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I4W80_RS15040	COG3584	3D domain protein
I4W80_RS15055	COG1252	NADH dehydrogenase
I4W80_RS15060	COG0492	ferredoxin-NADP+ reductase activity
I4W80_RS15075	COG0316	Belongs to the HesB IscA family
I4W80_RS15080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I4W80_RS15085	COG4844	belongs to the
I4W80_RS15090	COG1252	NADH dehydrogenase
I4W80_RS15100	COG4837	Protein of unknown function (DUF1462)
I4W80_RS15105	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I4W80_RS15110	COG1506	peptidase
I4W80_RS15110	COG0823	Involved in the tonB-independent uptake of proteins
I4W80_RS15110	COG4946	Tricorn protease homolog
I4W80_RS15115	COG0083	homoserine kinase activity
I4W80_RS15120	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I4W80_RS15125	COG0460	homoserine dehydrogenase
I4W80_RS15130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I4W80_RS15135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I4W80_RS15140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I4W80_RS15145	COG0647	UMP catabolic process
I4W80_RS15150	COG2445	Protein of unknown function DUF86
I4W80_RS15155	COG4470	Protein conserved in bacteria
I4W80_RS15165	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I4W80_RS15170	COG0739	heme binding
I4W80_RS15190	COG3377	Domain of unknown function (DUF1805)
I4W80_RS15195	COG0737	Belongs to the 5'-nucleotidase family
I4W80_RS15200	COG1801	Protein of unknown function DUF72
I4W80_RS15205	COG2508	Transcriptional regulator
I4W80_RS15215	COG2814	Major facilitator Superfamily
I4W80_RS15220	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I4W80_RS15225	COG2356	endonuclease I
I4W80_RS15240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_RS15245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_RS15250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I4W80_RS15270	COG5002	protein histidine kinase activity
I4W80_RS15270	COG0642	Histidine kinase
I4W80_RS15275	COG0745	RESPONSE REGULATOR receiver
I4W80_RS15280	COG2311	Membrane
I4W80_RS15290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I4W80_RS15295	COG1090	epimerase
I4W80_RS15300	COG1309	transcriptional regulator
I4W80_RS15310	COG0719	Fe-S assembly protein
I4W80_RS15315	COG0822	iron-sulfur transferase activity
I4W80_RS15320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I4W80_RS15325	COG0719	Fe-S assembly protein
I4W80_RS15330	COG0396	ATPase activity
I4W80_RS15340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I4W80_RS15345	COG1464	Belongs to the NlpA lipoprotein family
I4W80_RS15350	COG2011	ABC-type metal ion transport system permease component
I4W80_RS15355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I4W80_RS15365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4W80_RS15370	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I4W80_RS15380	COG0509	glycine decarboxylation via glycine cleavage system
I4W80_RS15385	COG1393	Belongs to the ArsC family
I4W80_RS15390	COG1960	acyl-CoA dehydrogenase activity
I4W80_RS15395	COG0183	Belongs to the thiolase family
I4W80_RS15400	COG1024	Enoyl-CoA hydratase
I4W80_RS15400	COG1250	3-hydroxyacyl-CoA dehydrogenase
I4W80_RS15415	COG5577	PFAM Coat F domain
I4W80_RS15425	COG1120	ATPase activity
I4W80_RS15435	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS15440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I4W80_RS15445	COG0745	RESPONSE REGULATOR receiver
I4W80_RS15450	COG2205	protein histidine kinase activity
I4W80_RS15450	COG2770	Histidine kinase
I4W80_RS15460	COG1309	transcriptional regulator
I4W80_RS15465	COG0114	fumarate hydratase activity
I4W80_RS15475	COG0697	spore germination
I4W80_RS15480	COG0814	amino acid
I4W80_RS15495	COG2197	response regulator
I4W80_RS15500	COG4585	Histidine kinase
I4W80_RS15505	COG4758	membrane
I4W80_RS15515	COG1842	Phage shock protein A
I4W80_RS15520	COG4758	membrane
I4W80_RS15525	COG2096	Adenosyltransferase
I4W80_RS15530	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS15535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I4W80_RS15545	COG3604	Transcriptional regulator
I4W80_RS15560	COG1454	alcohol dehydrogenase
I4W80_RS15565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I4W80_RS15570	COG1120	ATPase activity
I4W80_RS15575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_RS15580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I4W80_RS15590	COG2721	sulfolactate sulfo-lyase activity
I4W80_RS15595	COG0246	Mannitol dehydrogenase
I4W80_RS15600	COG1609	Transcriptional regulator
I4W80_RS15605	COG1904	glucuronate isomerase
I4W80_RS15610	COG2205	protein histidine kinase activity
I4W80_RS15615	COG0745	RESPONSE REGULATOR receiver
I4W80_RS15620	COG1120	ATPase activity
I4W80_RS15625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_RS15630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_RS15635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I4W80_RS15640	COG0531	amino acid
I4W80_RS15655	COG1988	membrane-bound metal-dependent
I4W80_RS15660	COG1368	sulfuric ester hydrolase activity
I4W80_RS15665	COG0725	ABC transporter, periplasmic molybdate-binding protein
I4W80_RS15670	COG4149	molybdate abc transporter
I4W80_RS15675	COG0656	L-ascorbic acid biosynthetic process
I4W80_RS15680	COG1940	carbohydrate kinase activity
I4W80_RS15685	COG0025	NhaP-type Na H and K H
I4W80_RS15690	COG2860	membrane
I4W80_RS15695	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I4W80_RS15700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I4W80_RS15705	COG2217	Heavy metal translocating P-type atpase
I4W80_RS15710	COG1121	(ABC) transporter
I4W80_RS15715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I4W80_RS15720	COG0803	Belongs to the bacterial solute-binding protein 9 family
I4W80_RS15730	COG3226	Transcriptional regulator
I4W80_RS15735	COG0784	Response regulator, receiver
I4W80_RS15740	COG4191	Histidine kinase
I4W80_RS15745	COG1027	Aspartate ammonia-lyase
I4W80_RS15755	COG2217	Heavy metal translocating P-type atpase
I4W80_RS15760	COG2608	mercury ion transmembrane transporter activity
I4W80_RS15765	COG1937	Protein conserved in bacteria
I4W80_RS15800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I4W80_RS15805	COG0557	exoribonuclease II activity
I4W80_RS15810	COG1647	Serine aminopeptidase, S33
I4W80_RS15815	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I4W80_RS15820	COG2002	toxin-antitoxin pair type II binding
I4W80_RS15825	COG1476	TRANSCRIPTIONal
I4W80_RS15830	COG1396	sequence-specific DNA binding
I4W80_RS15835	COG1396	sequence-specific DNA binding
I4W80_RS15840	COG1733	regulation of RNA biosynthetic process
I4W80_RS15845	COG1174	glycine betaine transport
I4W80_RS15850	COG1732	Glycine betaine
I4W80_RS15855	COG1174	glycine betaine transport
I4W80_RS15860	COG1125	glycine betaine transport
I4W80_RS15860	COG0517	IMP dehydrogenase activity
I4W80_RS15865	COG1510	regulation of RNA biosynthetic process
I4W80_RS15870	COG2095	MarC family integral membrane protein
I4W80_RS15880	COG0456	acetyltransferase
I4W80_RS15900	COG1131	(ABC) transporter
I4W80_RS15910	COG0148	phosphopyruvate hydratase activity
I4W80_RS15915	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I4W80_RS15920	COG0149	triose-phosphate isomerase activity
I4W80_RS15925	COG0126	phosphoglycerate kinase activity
I4W80_RS15930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I4W80_RS15935	COG2390	Transcriptional regulator
I4W80_RS15940	COG0833	amino acid
I4W80_RS15945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I4W80_RS15950	COG3829	transcription factor binding
I4W80_RS15955	COG2186	Transcriptional regulator
I4W80_RS15960	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I4W80_RS15970	COG0534	Mate efflux family protein
I4W80_RS15975	COG4608	Belongs to the ABC transporter superfamily
I4W80_RS15980	COG0444	Belongs to the ABC transporter superfamily
I4W80_RS15985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I4W80_RS15990	COG0601	transmembrane transport
I4W80_RS15995	COG0747	negative chemotaxis
I4W80_RS16000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I4W80_RS16005	COG0110	maltose O-acetyltransferase activity
I4W80_RS16010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I4W80_RS16015	COG2244	polysaccharide biosynthetic process
I4W80_RS16020	COG5039	Polysaccharide pyruvyl transferase
I4W80_RS16025	COG1216	Glycosyl transferase, family 2
I4W80_RS16035	COG0438	transferase activity, transferring glycosyl groups
I4W80_RS16040	COG1215	transferase activity, transferring glycosyl groups
I4W80_RS16045	COG0438	transferase activity, transferring glycosyl groups
I4W80_RS16050	COG1086	Polysaccharide biosynthesis protein
I4W80_RS16055	COG0489	protein tyrosine kinase activity
I4W80_RS16060	COG3944	biosynthesis protein
I4W80_RS16065	COG1396	sequence-specific DNA binding
I4W80_RS16075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I4W80_RS16080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_RS16085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_RS16090	COG0726	polysaccharide deacetylase
I4W80_RS16095	COG0488	(ABC) transporter
I4W80_RS16115	COG0601	transmembrane transport
I4W80_RS16120	COG0747	negative chemotaxis
I4W80_RS16125	COG1819	glycosyl
I4W80_RS16140	COG0740	serine-type endopeptidase activity
I4W80_RS16145	COG1611	Belongs to the LOG family
I4W80_RS16150	COG1694	Mazg nucleotide pyrophosphohydrolase
I4W80_RS16155	COG0659	secondary active sulfate transmembrane transporter activity
I4W80_RS16160	COG0288	reversible hydration of carbon dioxide
I4W80_RS16165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I4W80_RS16175	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I4W80_RS16180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_RS16185	COG1481	regulation of sporulation
I4W80_RS16190	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I4W80_RS16195	COG1660	Displays ATPase and GTPase activities
I4W80_RS16200	COG1051	belongs to the nudix hydrolase family
I4W80_RS16205	COG0492	ferredoxin-NADP+ reductase activity
I4W80_RS16210	COG3883	PFAM NLP P60 protein
I4W80_RS16210	COG0791	NLP P60 protein
I4W80_RS16215	COG0457	Tetratricopeptide repeat
I4W80_RS16220	COG0140	phosphoribosyl-ATP diphosphatase activity
I4W80_RS16220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I4W80_RS16225	COG0107	imidazoleglycerol-phosphate synthase activity
I4W80_RS16230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I4W80_RS16235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I4W80_RS16240	COG0131	Imidazoleglycerol-phosphate dehydratase
I4W80_RS16245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I4W80_RS16250	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I4W80_RS16255	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I4W80_RS16260	COG4990	cell redox homeostasis
I4W80_RS16265	COG2910	NAD(P)H-binding
I4W80_RS16270	COG1959	2 iron, 2 sulfur cluster binding
I4W80_RS16275	COG0110	maltose O-acetyltransferase activity
I4W80_RS16280	COG0546	phosphoglycolate phosphatase activity
I4W80_RS16285	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I4W80_RS16295	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I4W80_RS16300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I4W80_RS16305	COG0363	glucosamine-6-phosphate deaminase activity
I4W80_RS16310	COG2188	Transcriptional regulator
I4W80_RS16315	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I4W80_RS16320	COG1950	PFAM Membrane protein of
I4W80_RS16325	COG1983	PspC domain protein
I4W80_RS16330	COG3595	metallopeptidase activity
I4W80_RS16345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I4W80_RS16355	COG4897	Protein conserved in bacteria
I4W80_RS16360	COG3848	Pyruvate phosphate dikinase
I4W80_RS16360	COG0574	Belongs to the PEP-utilizing enzyme family
I4W80_RS16365	COG1309	transcriptional regulator
I4W80_RS16370	COG2814	Major facilitator Superfamily
I4W80_RS16380	COG0745	RESPONSE REGULATOR receiver
I4W80_RS16385	COG5002	protein histidine kinase activity
I4W80_RS16390	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I4W80_RS16395	COG0463	Glycosyl transferase, family 2
I4W80_RS16400	COG1113	amino acid transport
I4W80_RS16405	COG0778	Nitroreductase
I4W80_RS16410	COG1733	regulation of RNA biosynthetic process
I4W80_RS16415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I4W80_RS16425	COG0793	Belongs to the peptidase S41A family
I4W80_RS16425	COG3409	Peptidoglycan-binding domain 1 protein
I4W80_RS16430	COG0730	response to heat
I4W80_RS16435	COG0791	NLP P60 protein
I4W80_RS16435	COG3883	PFAM NLP P60 protein
I4W80_RS16440	COG2177	Part of the ABC transporter FtsEX involved in
I4W80_RS16445	COG2884	Cell division ATP-binding protein ftsE
I4W80_RS16450	COG2010	Cytochrome c
I4W80_RS16455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4W80_RS16475	COG0653	protein targeting
I4W80_RS16480	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I4W80_RS16485	COG0840	transmembrane signaling receptor activity
I4W80_RS16500	COG1516	flagellar protein fliS
I4W80_RS16505	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I4W80_RS16510	COG1334	flagellar protein FlaG
I4W80_RS16515	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I4W80_RS16520	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
I4W80_RS16530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I4W80_RS16535	COG4786	Flagellar basal body rod
I4W80_RS16535	COG1256	bacterial-type flagellum assembly
I4W80_RS16540	COG3418	PFAM FlgN family protein
I4W80_RS16555	COG1040	competence protein
I4W80_RS16565	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I4W80_RS16570	COG1307	EDD domain protein, DegV family
I4W80_RS16575	COG2197	response regulator
I4W80_RS16580	COG4585	Histidine kinase
I4W80_RS16585	COG1739	Uncharacterized protein family UPF0029
I4W80_RS16590	COG1316	TRANSCRIPTIONal
I4W80_RS16595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I4W80_RS16600	COG0438	transferase activity, transferring glycosyl groups
I4W80_RS16605	COG1215	transferase activity, transferring glycosyl groups
I4W80_RS16610	COG3206	protein involved in exopolysaccharide biosynthesis
I4W80_RS16615	COG3307	-O-antigen
I4W80_RS16620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I4W80_RS16625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I4W80_RS16630	COG0438	transferase activity, transferring glycosyl groups
I4W80_RS16630	COG0297	glycogen (starch) synthase activity
I4W80_RS16635	COG2244	polysaccharide biosynthetic process
I4W80_RS16650	COG2247	cell wall binding repeat
I4W80_RS16650	COG0860	N-Acetylmuramoyl-L-alanine amidase
I4W80_RS16655	COG0860	N-Acetylmuramoyl-L-alanine amidase
I4W80_RS16655	COG2247	cell wall binding repeat
I4W80_RS16660	COG2385	sporulation resulting in formation of a cellular spore
I4W80_RS16660	COG2247	cell wall binding repeat
I4W80_RS16670	COG1316	TRANSCRIPTIONal
I4W80_RS16675	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I4W80_RS16680	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I4W80_RS16685	COG1134	teichoic acid transport
I4W80_RS16690	COG1682	transport, permease protein
I4W80_RS16700	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I4W80_RS16710	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I4W80_RS16715	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I4W80_RS16720	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I4W80_RS16725	COG4193	domain, Protein
I4W80_RS16730	COG1482	cell wall glycoprotein biosynthetic process
I4W80_RS16740	COG1175	transmembrane transport
I4W80_RS16745	COG1653	transport
I4W80_RS16750	COG2197	response regulator
I4W80_RS16755	COG2972	Histidine kinase
I4W80_RS16765	COG0454	-acetyltransferase
I4W80_RS16770	COG0800	Aldolase
I4W80_RS16775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I4W80_RS16780	COG1609	Transcriptional regulator
I4W80_RS16785	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I4W80_RS16790	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS16795	COG0697	spore germination
I4W80_RS16800	COG0814	amino acid
I4W80_RS16815	COG2814	Major facilitator Superfamily
I4W80_RS16820	COG1316	TRANSCRIPTIONal
I4W80_RS16825	COG0561	phosphatase activity
I4W80_RS16830	COG0791	NLP P60 protein
I4W80_RS16840	COG2843	Capsule synthesis protein
I4W80_RS16850	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I4W80_RS16855	COG0697	spore germination
I4W80_RS16870	COG1609	Transcriptional regulator
I4W80_RS16875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I4W80_RS16880	COG1869	D-ribose catabolic process
I4W80_RS16885	COG1129	ABC transporter
I4W80_RS16890	COG1172	Belongs to the binding-protein-dependent transport system permease family
I4W80_RS16895	COG1879	ABC-type sugar transport system periplasmic component
I4W80_RS16900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I4W80_RS16905	COG0583	DNA-binding transcription factor activity
I4W80_RS16910	COG0028	Belongs to the TPP enzyme family
I4W80_RS16915	COG3527	Alpha-acetolactate decarboxylase
I4W80_RS16920	COG1522	sequence-specific DNA binding
I4W80_RS16925	COG2059	Chromate
I4W80_RS16930	COG2059	Chromate
I4W80_RS16935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I4W80_RS16945	COG4715	Zinc finger, swim domain protein
I4W80_RS16950	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I4W80_RS16955	COG1366	Belongs to the anti-sigma-factor antagonist family
I4W80_RS16955	COG2202	Pas domain
I4W80_RS16960	COG0561	phosphatase activity
I4W80_RS16975	COG1970	mechanosensitive ion channel activity
I4W80_RS16980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I4W80_RS16985	COG0457	Tetratricopeptide repeat
I4W80_RS16990	COG4786	Flagellar basal body rod
I4W80_RS16995	COG4786	Flagellar basal body rod
I4W80_RS17000	COG1077	Cell shape determining protein MreB Mrl
I4W80_RS17005	COG1609	Transcriptional regulator
I4W80_RS17010	COG1846	Transcriptional regulator
I4W80_RS17015	COG2814	Major facilitator Superfamily
I4W80_RS17020	COG0671	phosphoesterase, PA-phosphatase related
I4W80_RS17025	COG0477	Major facilitator Superfamily
I4W80_RS17030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4W80_RS17035	COG0765	amino acid transport
I4W80_RS17040	COG1126	abc transporter atp-binding protein
I4W80_RS17045	COG0004	ammonium transporteR
I4W80_RS17050	COG0347	Belongs to the P(II) protein family
I4W80_RS17055	COG0739	heme binding
I4W80_RS17060	COG1247	-acetyltransferase
I4W80_RS17100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I4W80_RS17105	COG0523	cobalamin synthesis protein
I4W80_RS17110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I4W80_RS17115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I4W80_RS17120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I4W80_RS17125	COG2223	nitrite transmembrane transporter activity
I4W80_RS17135	COG2304	oxidoreductase activity
I4W80_RS17140	COG2304	oxidoreductase activity
I4W80_RS17145	COG2385	sporulation resulting in formation of a cellular spore
I4W80_RS17150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I4W80_RS17160	COG4836	Membrane
I4W80_RS17170	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I4W80_RS17175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I4W80_RS17180	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I4W80_RS17185	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I4W80_RS17190	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I4W80_RS17195	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I4W80_RS17200	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I4W80_RS17205	COG0356	it plays a direct role in the translocation of protons across the membrane
I4W80_RS17215	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I4W80_RS17220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I4W80_RS17225	COG4475	Protein of unknown function (DUF436)
I4W80_RS17230	COG0698	ribose 5-phosphate isomerase
I4W80_RS17235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I4W80_RS17240	COG1971	Probably functions as a manganese efflux pump
I4W80_RS17245	COG0009	L-threonylcarbamoyladenylate synthase
I4W80_RS17250	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I4W80_RS17265	COG2890	protein-(glutamine-N5) methyltransferase activity
I4W80_RS17270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I4W80_RS17275	COG0789	Transcriptional regulator
I4W80_RS17280	COG0679	Auxin Efflux Carrier
I4W80_RS17285	COG0281	malic enzyme
I4W80_RS17290	COG1435	thymidine kinase activity
I4W80_RS17295	COG0254	rRNA binding
I4W80_RS17300	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I4W80_RS17305	COG1494	fructose-1,6-bisphosphatase
I4W80_RS17310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I4W80_RS17315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I4W80_RS17320	COG0191	fructose-bisphosphate aldolase activity
I4W80_RS17325	COG2204	response regulator
I4W80_RS17330	COG4821	SIS domain
I4W80_RS17335	COG0504	CTP synthase activity
I4W80_RS17340	COG3343	RNA polymerase activity
I4W80_RS17355	COG1960	acyl-CoA dehydrogenase activity
I4W80_RS17360	COG1960	acyl-CoA dehydrogenase activity
I4W80_RS17365	COG1250	3-hydroxyacyl-CoA dehydrogenase
I4W80_RS17370	COG0183	Belongs to the thiolase family
I4W80_RS17375	COG2181	nitrate reductase activity
I4W80_RS17375	COG0247	lactate metabolic process
I4W80_RS17380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I4W80_RS17385	COG4294	response to UV
I4W80_RS17395	COG1619	proteins homologs of microcin C7 resistance protein MccF
I4W80_RS17405	COG1132	(ABC) transporter
I4W80_RS17410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I4W80_RS17420	COG0018	arginyl-trna synthetase
I4W80_RS17425	COG4506	Protein conserved in bacteria
I4W80_RS17435	COG0010	Belongs to the arginase family
I4W80_RS17440	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I4W80_RS17445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I4W80_RS17455	COG1994	Peptidase M50
I4W80_RS17460	COG1942	4-Oxalocrotonate Tautomerase
I4W80_RS17470	COG3465	dGTPase activity
I4W80_RS17475	COG1078	dGTPase activity
I4W80_RS17480	COG4844	belongs to the
I4W80_RS17530	COG5444	nuclease activity
I4W80_RS17560	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I4W80_RS17570	COG0280	phosphate acetyltransferase
I4W80_RS17580	COG2814	Major facilitator Superfamily
I4W80_RS17585	COG1522	sequence-specific DNA binding
I4W80_RS17590	COG2814	Major facilitator Superfamily
I4W80_RS17595	COG0077	Prephenate dehydratase
I4W80_RS17600	COG1917	Cupin 2, conserved barrel domain protein
I4W80_RS17605	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS17610	COG0151	Belongs to the GarS family
I4W80_RS17615	COG0436	Aminotransferase
I4W80_RS17620	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_RS17625	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I4W80_RS17630	COG1091	dTDP-4-dehydrorhamnose reductase activity
I4W80_RS17635	COG1088	dTDP-glucose 4,6-dehydratase activity
I4W80_RS17640	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I4W80_RS17645	COG3980	spore coat polysaccharide biosynthesis protein
I4W80_RS17650	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
I4W80_RS17655	COG2089	acid synthase
I4W80_RS17660	COG0456	acetyltransferase
I4W80_RS17665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I4W80_RS17670	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I4W80_RS17675	COG0463	Glycosyl transferase, family 2
I4W80_RS17695	COG2363	Small membrane protein
I4W80_RS17700	COG2233	PERMEase
I4W80_RS17710	COG1012	belongs to the aldehyde dehydrogenase family
I4W80_RS17715	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I4W80_RS17720	COG1216	Glycosyl transferase, family 2
I4W80_RS17730	COG0351	phosphomethylpyrimidine kinase
I4W80_RS17745	COG1621	beta-fructofuranosidase activity
I4W80_RS17750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_RS17750	COG1263	PTS System
I4W80_RS17755	COG3711	transcriptional antiterminator
I4W80_RS17765	COG1404	Belongs to the peptidase S8 family
I4W80_RS17775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I4W80_RS17780	COG0778	Nitroreductase
I4W80_RS17785	COG0772	Belongs to the SEDS family
I4W80_RS17795	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I4W80_RS17800	COG1845	cytochrome c oxidase, subunit III
I4W80_RS17805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I4W80_RS17810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I4W80_RS17820	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I4W80_RS17825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I4W80_RS17830	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I4W80_RS17845	COG2246	polysaccharide biosynthetic process
I4W80_RS17865	COG3162	membrane
I4W80_RS17870	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I4W80_RS17885	COG0352	thiamine-phosphate diphosphorylase activity
I4W80_RS17890	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I4W80_RS17895	COG0583	DNA-binding transcription factor activity
I4W80_RS17900	COG1380	Effector of murein hydrolase LrgA
I4W80_RS17905	COG1346	cytolysis
I4W80_RS17910	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I4W80_RS17915	COG0346	lactoylglutathione lyase activity
I4W80_RS17925	COG0765	amino acid transport
I4W80_RS17930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4W80_RS17935	COG0457	Tetratricopeptide repeat
I4W80_RS17945	COG2357	RelA SpoT domain protein
I4W80_RS17950	COG1172	Belongs to the binding-protein-dependent transport system permease family
I4W80_RS17955	COG1129	ABC transporter
I4W80_RS17965	COG3420	alginic acid biosynthetic process
I4W80_RS17970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I4W80_RS17980	COG1486	melibiose metabolic process
I4W80_RS17985	COG1447	Phosphotransferase system cellobiose-specific component IIA
I4W80_RS17990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4W80_RS17995	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4W80_RS18000	COG3711	transcriptional antiterminator
I4W80_RS18000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_RS18015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I4W80_RS18030	COG1595	DNA-templated transcription, initiation
I4W80_RS18040	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I4W80_RS18045	COG4988	ABC transporter
I4W80_RS18050	COG1294	oxidase, subunit
I4W80_RS18055	COG1271	oxidase subunit
I4W80_RS18060	COG1120	ATPase activity
I4W80_RS18065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_RS18070	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I4W80_RS18075	COG4509	Sortase family
I4W80_RS18100	COG5386	Cell surface protein
I4W80_RS18105	COG5386	Cell surface protein
I4W80_RS18110	COG1733	regulation of RNA biosynthetic process
I4W80_RS18115	COG2514	catechol 2,3-dioxygenase activity
I4W80_RS18120	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I4W80_RS18120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I4W80_RS18125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I4W80_RS18125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I4W80_RS18135	COG0726	polysaccharide deacetylase
I4W80_RS18140	COG1447	Phosphotransferase system cellobiose-specific component IIA
I4W80_RS18145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4W80_RS18150	COG2723	6-phospho-beta-galactosidase activity
I4W80_RS18155	COG1312	Catalyzes the dehydration of D-mannonate
I4W80_RS18160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4W80_RS18165	COG3711	transcriptional antiterminator
I4W80_RS18165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_RS18190	COG1757	Na H antiporter
I4W80_RS18195	COG1027	Aspartate ammonia-lyase
I4W80_RS18200	COG0252	asparaginase activity
I4W80_RS18205	COG1396	sequence-specific DNA binding
I4W80_RS18230	COG4842	Belongs to the WXG100 family
I4W80_RS18235	COG2195	Cleaves the N-terminal amino acid of tripeptides
I4W80_RS18250	COG1737	Transcriptional regulator
I4W80_RS18255	COG2084	Dehydrogenase
I4W80_RS18265	COG2610	gluconate transmembrane transporter activity
I4W80_RS18270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I4W80_RS18295	COG2723	6-phospho-beta-galactosidase activity
I4W80_RS18300	COG2190	(PTS) system
I4W80_RS18300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_RS18300	COG1263	PTS System
I4W80_RS18305	COG3711	transcriptional antiterminator
I4W80_RS18310	COG3878	Protein conserved in bacteria
I4W80_RS18320	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I4W80_RS18325	COG1122	ATPase activity
I4W80_RS18330	COG4721	ABC-type cobalt transport system, permease component
I4W80_RS18335	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I4W80_RS18370	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I4W80_RS18375	COG0778	Nitroreductase
I4W80_RS18380	COG1846	Transcriptional regulator
I4W80_RS18385	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I4W80_RS18390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I4W80_RS18395	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I4W80_RS18400	COG2390	Transcriptional regulator
I4W80_RS18410	COG2755	lipolytic protein G-D-S-L family
I4W80_RS18410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I4W80_RS18415	COG0477	Major facilitator Superfamily
I4W80_RS18420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I4W80_RS18425	COG2226	methyltransferase
I4W80_RS18435	COG0561	phosphatase activity
I4W80_RS18440	COG0789	Transcriptional regulator
I4W80_RS18445	COG0673	inositol 2-dehydrogenase activity
I4W80_RS18450	COG0840	transmembrane signaling receptor activity
I4W80_RS18455	COG1113	amino acid transport
I4W80_RS18460	COG4335	DNA alkylation repair
I4W80_RS18470	COG1070	Carbohydrate kinase
I4W80_RS18475	COG1737	Transcriptional regulator
I4W80_RS18505	COG0583	DNA-binding transcription factor activity
I4W80_RS18510	COG1609	Transcriptional regulator
I4W80_RS18515	COG2182	Extracellular solute-binding protein
I4W80_RS18520	COG1175	transmembrane transport
I4W80_RS18525	COG3833	ABC-type maltose transport systems, permease component
I4W80_RS18535	COG1874	Beta-galactosidase
I4W80_RS18540	COG2851	Citrate transporter
I4W80_RS18550	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I4W80_RS18555	COG1131	(ABC) transporter
I4W80_RS18560	COG2824	Alkylphosphonate utilization operon protein PhnA
I4W80_RS18565	COG1929	Belongs to the glycerate kinase type-1 family
I4W80_RS18570	COG2610	gluconate transmembrane transporter activity
I4W80_RS18575	COG3835	regulator
I4W80_RS18580	COG1309	transcriptional regulator
I4W80_RS18585	COG2814	Major facilitator Superfamily
I4W80_RS18595	COG1136	(ABC) transporter
I4W80_RS18600	COG0457	Tetratricopeptide repeat
I4W80_RS18605	COG3711	transcriptional antiterminator
I4W80_RS18610	COG2723	6-phospho-beta-galactosidase activity
I4W80_RS18615	COG2190	(PTS) system
I4W80_RS18615	COG1263	PTS System
I4W80_RS18615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_RS18640	COG0494	nUDIX hydrolase
I4W80_RS18655	COG1113	amino acid transport
I4W80_RS18660	COG1609	Transcriptional regulator
I4W80_RS18665	COG2814	Major facilitator Superfamily
I4W80_RS18670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I4W80_RS18675	COG2814	Major facilitator Superfamily
I4W80_RS18695	COG5444	nuclease activity
I4W80_RS18705	COG2723	6-phospho-beta-galactosidase activity
I4W80_RS18710	COG1263	PTS System
I4W80_RS18710	COG2190	(PTS) system
I4W80_RS18710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_RS18715	COG2188	Transcriptional regulator
I4W80_RS18725	COG0384	phenazine biosynthesis protein PhzF
I4W80_RS18730	COG0583	DNA-binding transcription factor activity
I4W80_RS18750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I4W80_RS18765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I4W80_RS18790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I4W80_RS18795	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I4W80_RS18805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I4W80_RS18815	COG4720	Psort location CytoplasmicMembrane, score
I4W80_RS18835	COG0456	acetyltransferase
I4W80_RS18840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I4W80_RS18845	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I4W80_RS18850	COG4853	Protein conserved in bacteria
I4W80_RS18855	COG4863	YycH protein
I4W80_RS18860	COG5002	protein histidine kinase activity
I4W80_RS18865	COG0745	RESPONSE REGULATOR receiver
I4W80_RS18890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I4W80_RS18900	COG2311	Membrane
I4W80_RS18905	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I4W80_RS18910	COG1309	transcriptional regulator
I4W80_RS18915	COG2124	cytochrome p450
I4W80_RS18920	COG0346	lactoylglutathione lyase activity
I4W80_RS18925	COG0305	Participates in initiation and elongation during chromosome replication
I4W80_RS18940	COG2819	hydrolase of the alpha beta superfamily
I4W80_RS18945	COG2207	Transcriptional regulator
I4W80_RS18945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I4W80_RS18950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I4W80_RS18955	COG2819	hydrolase of the alpha beta superfamily
I4W80_RS18960	COG3093	addiction module antidote protein HigA
I4W80_RS18965	COG2807	transmembrane transport
I4W80_RS18970	COG0359	binds to the 23S rRNA
I4W80_RS18975	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I4W80_RS18980	COG4241	membrane
I4W80_RS18985	COG1227	inorganic diphosphatase activity
I4W80_RS18995	COG1595	DNA-templated transcription, initiation
I4W80_RS19005	COG0753	catalase activity
I4W80_RS19010	COG0655	NAD(P)H dehydrogenase (quinone) activity
I4W80_RS19015	COG0400	carboxylic ester hydrolase activity
I4W80_RS19020	COG0346	lactoylglutathione lyase activity
I4W80_RS19025	COG1174	glycine betaine transport
I4W80_RS19030	COG0517	IMP dehydrogenase activity
I4W80_RS19030	COG1125	glycine betaine transport
I4W80_RS19035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I4W80_RS19040	COG0629	single-stranded DNA binding
I4W80_RS19045	COG0360	Binds together with S18 to 16S ribosomal RNA
I4W80_RS19050	COG0012	GTP binding
I4W80_RS19055	COG4481	Protein conserved in bacteria
I4W80_RS19070	COG3949	Membrane
I4W80_RS19080	COG1475	DNA binding
I4W80_RS19085	COG1192	Involved in chromosome partitioning
I4W80_RS19095	COG1475	DNA binding
I4W80_RS19100	COG0357	Ribosomal RNA small subunit methyltransferase G
I4W80_RS19105	COG0445	tRNA wobble uridine modification
I4W80_RS19110	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I4W80_RS19115	COG1847	R3H domain protein
I4W80_RS19120	COG0706	membrane insertase activity
I4W80_RS19125	COG0594	ribonuclease P activity
I4W80_RS19130	COG0230	Belongs to the bacterial ribosomal protein bL34 family