locus-tag	class	description
RI02_RS00020	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
RI02_RS00025	COG3853	Toxic anion resistance protein (TelA)
RI02_RS00030	COG1982	Orn Lys Arg decarboxylase major
RI02_RS00035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RI02_RS00040	COG3870	Protein conserved in bacteria
RI02_RS00045	COG1728	Protein conserved in bacteria
RI02_RS00050	COG0470	DNA polymerase III
RI02_RS00055	COG1774	PSP1 C-terminal conserved region
RI02_RS00060	COG4467	Involved in initiation control of chromosome replication
RI02_RS00065	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
RI02_RS00070	COG2827	Endonuclease containing a URI domain
RI02_RS00075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RI02_RS00080	COG2002	toxin-antitoxin pair type II binding
RI02_RS00085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RI02_RS00085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RI02_RS00090	COG0084	hydrolase, TatD family'
RI02_RS00095	COG3583	domain protein
RI02_RS00095	COG3584	3D domain protein
RI02_RS00100	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
RI02_RS00105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RI02_RS00115	COG4466	Protein conserved in bacteria
RI02_RS00125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RI02_RS00130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RI02_RS00135	COG0251	oxidation-reduction process
RI02_RS00140	COG2088	sporulation resulting in formation of a cellular spore
RI02_RS00150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RI02_RS00155	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RI02_RS00160	COG0193	aminoacyl-tRNA hydrolase activity
RI02_RS00170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RI02_RS00175	COG2002	toxin-antitoxin pair type II binding
RI02_RS00180	COG2244	polysaccharide biosynthetic process
RI02_RS00185	COG3956	TIGRFAM MazG family protein
RI02_RS00190	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RI02_RS00205	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RI02_RS00210	COG1098	S1 RNA binding domain
RI02_RS00225	COG2208	phosphoserine phosphatase activity
RI02_RS00230	COG2304	oxidoreductase activity
RI02_RS00235	COG0515	serine threonine protein kinase
RI02_RS00240	COG0037	tRNA processing
RI02_RS00245	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RI02_RS00250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RI02_RS00255	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RI02_RS00260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RI02_RS00265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RI02_RS00270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RI02_RS00275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RI02_RS00280	COG0512	Glutamine amidotransferase of anthranilate synthase
RI02_RS00285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RI02_RS00290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RI02_RS00295	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RI02_RS00300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RI02_RS00305	COG1396	sequence-specific DNA binding
RI02_RS00310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RI02_RS00315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RI02_RS00395	COG4463	regulation of RNA biosynthetic process
RI02_RS00400	COG3880	PFAM UvrB UvrC protein
RI02_RS00405	COG3869	Catalyzes the specific phosphorylation of arginine residues in
RI02_RS00410	COG0542	response to heat
RI02_RS00415	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RI02_RS00420	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
RI02_RS00425	COG4956	integral membrane protein (PIN domain superfamily)
RI02_RS00430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RI02_RS00435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RI02_RS00440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RI02_RS00445	COG1045	serine acetyltransferase
RI02_RS00450	COG0215	cysteine-tRNA ligase activity
RI02_RS00455	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
RI02_RS00460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RI02_RS00465	COG3688	RNA-binding protein containing a PIN domain
RI02_RS00470	COG1595	DNA-templated transcription, initiation
RI02_RS00475	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RI02_RS00480	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RI02_RS00485	COG0250	Participates in transcription elongation, termination and antitermination
RI02_RS00495	COG0081	regulation of translation
RI02_RS00500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RI02_RS00505	COG0222	ribosome binding
RI02_RS00510	COG2813	Specifically methylates the guanine in position
RI02_RS00515	COG0085	RNA polymerase activity
RI02_RS00520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RI02_RS00525	COG1358	cellular component organization or biogenesis
RI02_RS00530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RI02_RS00535	COG0049	tRNA binding
RI02_RS00540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RI02_RS00545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RI02_RS00550	COG0596	Alpha beta hydrolase
RI02_RS00560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RI02_RS00565	COG0088	Forms part of the polypeptide exit tunnel
RI02_RS00570	COG0089	rRNA binding
RI02_RS00575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RI02_RS00580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RI02_RS00585	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RI02_RS00590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RI02_RS00595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RI02_RS00600	COG0255	Belongs to the universal ribosomal protein uL29 family
RI02_RS00605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RI02_RS00610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RI02_RS00615	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RI02_RS00620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RI02_RS00625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RI02_RS00630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RI02_RS00635	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RI02_RS00640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RI02_RS00645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RI02_RS00650	COG1841	ribosomal large subunit assembly
RI02_RS00655	COG0200	Binds to the 23S rRNA
RI02_RS00660	COG0201	protein transport
RI02_RS00665	COG0563	adenylate kinase activity
RI02_RS00670	COG0024	Methionine aminopeptidase
RI02_RS00675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RI02_RS00680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RI02_RS00685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RI02_RS00690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RI02_RS00695	COG0202	RNA polymerase activity
RI02_RS00700	COG0203	ribosomal protein L17
RI02_RS00705	COG1122	ATPase activity
RI02_RS00710	COG1122	ATPase activity
RI02_RS00715	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RI02_RS00720	COG0101	tRNA pseudouridine synthase activity
RI02_RS00725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RI02_RS00730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RI02_RS00735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RI02_RS00760	COG1136	(ABC) transporter
RI02_RS00780	COG0860	N-Acetylmuramoyl-L-alanine amidase
RI02_RS00785	COG0489	protein tyrosine kinase activity
RI02_RS00795	COG2194	sulfuric ester hydrolase activity
RI02_RS00800	COG0726	polysaccharide deacetylase
RI02_RS00830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RI02_RS00835	COG0659	secondary active sulfate transmembrane transporter activity
RI02_RS00840	COG0385	Bile acid
RI02_RS00845	COG3876	Protein conserved in bacteria
RI02_RS00850	COG1472	Belongs to the glycosyl hydrolase 3 family
RI02_RS00855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RI02_RS00860	COG1263	PTS System
RI02_RS00860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RI02_RS00865	COG1737	Transcriptional regulator
RI02_RS00870	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
RI02_RS00905	COG1595	DNA-templated transcription, initiation
RI02_RS00910	COG5662	AntiSigma factor
RI02_RS00915	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
RI02_RS00920	COG4856	YbbR-like protein
RI02_RS00925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RI02_RS00930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RI02_RS00950	COG1131	(ABC) transporter
RI02_RS00960	COG1136	(ABC) transporter
RI02_RS00970	COG1695	Transcriptional regulator
RI02_RS00985	COG0535	radical SAM domain protein
RI02_RS00990	COG1266	CAAX protease self-immunity
RI02_RS00995	COG1131	(ABC) transporter
RI02_RS01005	COG1413	lyase activity
RI02_RS01010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RI02_RS01020	COG2311	Membrane
RI02_RS01040	COG1476	TRANSCRIPTIONal
RI02_RS01050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RI02_RS01055	COG2207	Transcriptional regulator
RI02_RS01070	COG1131	(ABC) transporter
RI02_RS01085	COG1113	amino acid transport
RI02_RS01090	COG0584	glycerophosphoryl diester phosphodiesterase
RI02_RS01095	COG2271	Major facilitator Superfamily
RI02_RS01105	COG1331	Highly conserved protein containing a thioredoxin domain
RI02_RS01110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RI02_RS01125	COG0640	Transcriptional regulator
RI02_RS01140	COG1937	Protein conserved in bacteria
RI02_RS01145	COG2210	Belongs to the sulfur carrier protein TusA family
RI02_RS01155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RI02_RS01155	COG0425	Belongs to the sulfur carrier protein TusA family
RI02_RS01160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RI02_RS01160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RI02_RS01165	COG0425	Belongs to the sulfur carrier protein TusA family
RI02_RS01170	COG0730	response to heat
RI02_RS01180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RI02_RS01185	COG2814	Major facilitator Superfamily
RI02_RS01200	COG1846	Transcriptional regulator
RI02_RS01205	COG1683	Conserved Protein
RI02_RS01215	COG0656	L-ascorbic acid biosynthetic process
RI02_RS01220	COG0371	Dehydrogenase
RI02_RS01225	COG1054	Belongs to the UPF0176 family
RI02_RS01230	COG0531	amino acid
RI02_RS01240	COG3711	transcriptional antiterminator
RI02_RS01245	COG2190	(PTS) system
RI02_RS01245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RI02_RS01245	COG1263	PTS System
RI02_RS01250	COG2723	6-phospho-beta-galactosidase activity
RI02_RS01265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RI02_RS01265	COG3711	transcriptional antiterminator
RI02_RS01270	COG1940	carbohydrate kinase activity
RI02_RS01275	COG0383	alpha-mannosidase activity
RI02_RS01280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RI02_RS01285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RI02_RS01295	COG1404	Belongs to the peptidase S8 family
RI02_RS01310	COG0833	amino acid
RI02_RS01315	COG2040	homocysteine
RI02_RS01320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RI02_RS01340	COG2814	Major facilitator Superfamily
RI02_RS01345	COG0456	acetyltransferase
RI02_RS01360	COG1404	Belongs to the peptidase S8 family
RI02_RS01370	COG1309	transcriptional regulator
RI02_RS01375	COG1917	Cupin 2, conserved barrel domain protein
RI02_RS01380	COG1846	Transcriptional regulator
RI02_RS01385	COG0318	PFAM AMP-dependent synthetase and ligase
RI02_RS01390	COG0531	amino acid
RI02_RS01400	COG0596	Alpha beta hydrolase
RI02_RS01405	COG1115	amino acid carrier protein
RI02_RS01410	COG2066	Belongs to the glutaminase family
RI02_RS01415	COG4191	Histidine kinase
RI02_RS01420	COG0784	Response regulator, receiver
RI02_RS01425	COG3012	SEC-C Motif Domain Protein
RI02_RS01425	COG1405	negative regulation of cell septum assembly
RI02_RS01435	COG0667	Aldo Keto reductase
RI02_RS01440	COG3290	protein histidine kinase activity
RI02_RS01445	COG3279	Response regulator of the LytR AlgR family
RI02_RS01450	COG4555	ABC transporter
RI02_RS01455	COG1668	transmembrane transport
RI02_RS01475	COG3773	Cell wall hydrolase
RI02_RS01480	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS01490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RI02_RS01495	COG2310	stress, protein
RI02_RS01500	COG2310	stress, protein
RI02_RS01505	COG2310	stress, protein
RI02_RS01510	COG0861	Integral membrane protein TerC family
RI02_RS01540	COG3853	Toxic anion resistance protein (TelA)
RI02_RS01545	COG4175	Glycine betaine
RI02_RS01545	COG0517	IMP dehydrogenase activity
RI02_RS01550	COG4176	ABC-type proline glycine betaine transport system permease component
RI02_RS01555	COG2113	Glycine betaine
RI02_RS01570	COG1473	amidohydrolase
RI02_RS01575	COG1288	antiporter activity
RI02_RS01580	COG0039	L-malate dehydrogenase activity
RI02_RS01585	COG1620	l-lactate permease
RI02_RS01590	COG1609	Transcriptional regulator
RI02_RS01595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RI02_RS01600	COG0561	phosphatase activity
RI02_RS01605	COG0673	inositol 2-dehydrogenase activity
RI02_RS01610	COG0738	Major facilitator superfamily
RI02_RS01615	COG1280	lysine exporter protein (LysE YggA)
RI02_RS01630	COG3403	YqcI/YcgG family
RI02_RS01635	COG1113	amino acid transport
RI02_RS01640	COG3665	Urea carboxylase-associated protein
RI02_RS01645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RI02_RS01655	COG1012	belongs to the aldehyde dehydrogenase family
RI02_RS01660	COG0710	3-dehydroquinate dehydratase activity
RI02_RS01665	COG0028	Belongs to the TPP enzyme family
RI02_RS01675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RI02_RS01680	COG2271	Major facilitator Superfamily
RI02_RS01695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RI02_RS01700	COG2226	methyltransferase
RI02_RS01705	COG0583	DNA-binding transcription factor activity
RI02_RS01710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RI02_RS01715	COG3458	cephalosporin-C deacetylase activity
RI02_RS01725	COG3541	Predicted nucleotidyltransferase
RI02_RS01730	COG0506	proline dehydrogenase activity
RI02_RS01735	COG1012	belongs to the aldehyde dehydrogenase family
RI02_RS01740	COG2508	Transcriptional regulator
RI02_RS01745	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RI02_RS01750	COG0765	amino acid transport
RI02_RS01755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RI02_RS01765	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RI02_RS01770	COG1522	sequence-specific DNA binding
RI02_RS01775	COG2746	aminoglycoside 3-N-acetyltransferase activity
RI02_RS01785	COG3290	protein histidine kinase activity
RI02_RS01785	COG0840	transmembrane signaling receptor activity
RI02_RS01790	COG3209	COG3209 Rhs family protein
RI02_RS01810	COG3842	ATPase activity
RI02_RS01815	COG1176	ABC-type spermidine putrescine transport system, permease component I
RI02_RS01825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RI02_RS01830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RI02_RS01835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RI02_RS01850	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
RI02_RS01855	COG0697	spore germination
RI02_RS01860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RI02_RS01870	COG3708	Transcriptional regulator
RI02_RS01870	COG2207	Transcriptional regulator
RI02_RS01880	COG2364	Membrane
RI02_RS01885	COG1126	abc transporter atp-binding protein
RI02_RS01890	COG0765	amino acid transport
RI02_RS01895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RI02_RS01900	COG0412	Dienelactone hydrolase
RI02_RS01905	COG0833	amino acid
RI02_RS01910	COG3104	oligopeptide transport
RI02_RS01915	COG5434	Belongs to the glycosyl hydrolase 28 family
RI02_RS01920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RI02_RS01925	COG0456	acetyltransferase
RI02_RS01930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RI02_RS01935	COG0765	amino acid transport
RI02_RS01940	COG1126	abc transporter atp-binding protein
RI02_RS01945	COG1473	amidohydrolase
RI02_RS01950	COG2079	MmgE PrpD family protein
RI02_RS01960	COG0745	RESPONSE REGULATOR receiver
RI02_RS01965	COG3850	Histidine kinase
RI02_RS01965	COG5002	protein histidine kinase activity
RI02_RS01970	COG1366	Belongs to the anti-sigma-factor antagonist family
RI02_RS01975	COG0527	aspartate kinase activity
RI02_RS01980	COG2814	Major facilitator Superfamily
RI02_RS01985	COG1309	transcriptional regulator
RI02_RS01995	COG0640	Transcriptional regulator
RI02_RS02005	COG0583	DNA-binding transcription factor activity
RI02_RS02010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RI02_RS02015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RI02_RS02020	COG0531	amino acid
RI02_RS02025	COG1012	belongs to the aldehyde dehydrogenase family
RI02_RS02030	COG2249	NAD(P)H dehydrogenase (quinone) activity
RI02_RS02035	COG4549	nuclear export factor GLE1
RI02_RS02040	COG2372	response to copper ion
RI02_RS02040	COG1276	copper resistance
RI02_RS02045	COG2213	PTS system mannitol-specific
RI02_RS02050	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RI02_RS02055	COG0246	Mannitol dehydrogenase
RI02_RS02060	COG0840	transmembrane signaling receptor activity
RI02_RS02095	COG0346	lactoylglutathione lyase activity
RI02_RS02105	COG0561	phosphatase activity
RI02_RS02110	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RI02_RS02115	COG1914	H( )-stimulated, divalent metal cation uptake system
RI02_RS02120	COG4336	lyase activity
RI02_RS02125	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RI02_RS02130	COG1984	allophanate hydrolase subunit 2
RI02_RS02135	COG1414	Transcriptional regulator
RI02_RS02140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RI02_RS02145	COG2755	lipolytic protein G-D-S-L family
RI02_RS02155	COG3711	transcriptional antiterminator
RI02_RS02160	COG2226	methyltransferase
RI02_RS02165	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS02170	COG3871	stress protein (general stress protein 26)
RI02_RS02190	COG2814	Major facilitator Superfamily
RI02_RS02195	COG1802	Transcriptional regulator
RI02_RS02200	COG2207	Transcriptional regulator
RI02_RS02200	COG1917	Cupin 2, conserved barrel domain protein
RI02_RS02205	COG0697	spore germination
RI02_RS02210	COG0473	3-isopropylmalate dehydrogenase activity
RI02_RS02215	COG0551	DNA topoisomerase type I activity
RI02_RS02215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RI02_RS02220	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
RI02_RS02225	COG3706	GGDEF domain
RI02_RS02230	COG5298	Protein conserved in bacteria
RI02_RS02235	COG1215	transferase activity, transferring glycosyl groups
RI02_RS02245	COG0531	amino acid
RI02_RS02250	COG0028	Belongs to the TPP enzyme family
RI02_RS02255	COG5444	nuclease activity
RI02_RS02285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RI02_RS02290	COG1914	H( )-stimulated, divalent metal cation uptake system
RI02_RS02295	COG2261	transglycosylase associated protein
RI02_RS02300	COG2217	Heavy metal translocating P-type atpase
RI02_RS02305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RI02_RS02310	COG3290	protein histidine kinase activity
RI02_RS02315	COG4565	transcriptional regulatory protein
RI02_RS02320	COG1301	dicarboxylic acid transport
RI02_RS02325	COG0628	permease
RI02_RS02330	COG1301	dicarboxylic acid transport
RI02_RS02335	COG1131	(ABC) transporter
RI02_RS02340	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
RI02_RS02355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RI02_RS02360	COG1181	Belongs to the D-alanine--D-alanine ligase family
RI02_RS02365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RI02_RS02380	COG0513	Belongs to the DEAD box helicase family
RI02_RS02385	COG3402	PFAM membrane-flanked domain
RI02_RS02390	COG3428	Bacterial PH domain
RI02_RS02395	COG0705	Rhomboid family
RI02_RS02400	COG0736	holo-[acyl-carrier-protein] synthase activity
RI02_RS02405	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RI02_RS02410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RI02_RS02415	COG0864	Transcriptional regulator
RI02_RS02420	COG2337	Toxic component of a toxin-antitoxin (TA) module
RI02_RS02425	COG1366	Belongs to the anti-sigma-factor antagonist family
RI02_RS02430	COG1366	Belongs to the anti-sigma-factor antagonist family
RI02_RS02435	COG2172	sigma factor antagonist activity
RI02_RS02440	COG2208	phosphoserine phosphatase activity
RI02_RS02445	COG1366	Belongs to the anti-sigma-factor antagonist family
RI02_RS02450	COG2172	sigma factor antagonist activity
RI02_RS02455	COG1191	sigma factor activity
RI02_RS02460	COG2208	phosphoserine phosphatase activity
RI02_RS02465	COG2183	response to ionizing radiation
RI02_RS02475	COG3091	SprT-like family
RI02_RS02480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RI02_RS02485	COG0022	dehydrogenase e1 component
RI02_RS02490	COG0508	dehydrogenase complex catalyzes the overall conversion of
RI02_RS02495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RI02_RS02500	COG3284	Transcriptional regulator
RI02_RS02545	COG1278	Cold shock
RI02_RS02550	COG2190	(PTS) system
RI02_RS02550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RI02_RS02550	COG1263	PTS System
RI02_RS02555	COG3394	polysaccharide catabolic process
RI02_RS02560	COG3711	transcriptional antiterminator
RI02_RS02565	COG1064	alcohol dehydrogenase
RI02_RS02570	COG0789	Transcriptional regulator
RI02_RS02590	COG0477	Major facilitator Superfamily
RI02_RS02595	COG0657	acetylesterase activity
RI02_RS02605	COG4221	oxidoreductase activity
RI02_RS02615	COG0252	asparaginase activity
RI02_RS02620	COG2267	carboxylic ester hydrolase activity
RI02_RS02635	COG2814	Major facilitator Superfamily
RI02_RS02640	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
RI02_RS02645	COG2409	Drug exporters of the RND superfamily
RI02_RS02650	COG4585	Histidine kinase
RI02_RS02655	COG2197	response regulator
RI02_RS02700	COG1309	transcriptional regulator
RI02_RS02705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RI02_RS02710	COG1846	Transcriptional regulator
RI02_RS02715	COG0778	Nitroreductase
RI02_RS02730	COG1396	sequence-specific DNA binding
RI02_RS02740	COG0456	acetyltransferase
RI02_RS02755	COG4122	O-methyltransferase activity
RI02_RS02765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
RI02_RS02770	COG0697	spore germination
RI02_RS02780	COG1301	dicarboxylic acid transport
RI02_RS02820	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RI02_RS02825	COG0802	atpase or kinase
RI02_RS02830	COG1214	PFAM Peptidase M22, glycoprotease
RI02_RS02835	COG0456	acetyltransferase
RI02_RS02840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RI02_RS02845	COG0488	(ABC) transporter
RI02_RS02850	COG0315	cyclic pyranopterin monophosphate synthase activity
RI02_RS02855	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
RI02_RS02860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RI02_RS02865	COG0805	protein transport
RI02_RS02880	COG1266	CAAX protease self-immunity
RI02_RS02885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RI02_RS02890	COG0459	protein refolding
RI02_RS02895	COG1846	Transcriptional regulator
RI02_RS02900	COG0456	acetyltransferase
RI02_RS02905	COG2808	Putative FMN-binding domain
RI02_RS02910	COG1876	peptidase activity
RI02_RS02935	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RI02_RS02940	COG0823	Involved in the tonB-independent uptake of proteins
RI02_RS02950	COG2132	Multicopper oxidase
RI02_RS02955	COG1113	amino acid transport
RI02_RS02960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RI02_RS02965	COG0714	Associated with various cellular activities
RI02_RS02970	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
RI02_RS02975	COG1305	Transglutaminase-like
RI02_RS02980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RI02_RS02980	COG0519	Catalyzes the synthesis of GMP from XMP
RI02_RS03005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RI02_RS03015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RI02_RS03045	COG3279	Response regulator of the LytR AlgR family
RI02_RS03065	COG1595	DNA-templated transcription, initiation
RI02_RS03075	COG2814	Major facilitator Superfamily
RI02_RS03080	COG0583	DNA-binding transcription factor activity
RI02_RS03085	COG2252	PERMEase
RI02_RS03095	COG5583	Uncharacterized small protein (DUF2292)
RI02_RS03100	COG3064	Membrane
RI02_RS03105	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
RI02_RS03115	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RI02_RS03120	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RI02_RS03125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RI02_RS03130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RI02_RS03135	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RI02_RS03140	COG0047	phosphoribosylformylglycinamidine synthase activity
RI02_RS03145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RI02_RS03150	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RI02_RS03155	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RI02_RS03160	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RI02_RS03165	COG0138	bifunctional purine biosynthesis protein purh
RI02_RS03170	COG0151	Belongs to the GarS family
RI02_RS03190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RI02_RS03195	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RI02_RS03200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RI02_RS03205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RI02_RS03215	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RI02_RS03220	COG4496	protein, YerC YecD
RI02_RS03230	COG0069	glutamate synthase activity
RI02_RS03245	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
RI02_RS03250	COG0210	DNA helicase
RI02_RS03255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RI02_RS03260	COG4851	CamS sex pheromone cAM373 precursor
RI02_RS03265	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RI02_RS03270	COG1285	pathogenesis
RI02_RS03275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RI02_RS03280	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RI02_RS03285	COG0154	amidase activity
RI02_RS03290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RI02_RS03295	COG1309	transcriptional regulator
RI02_RS03300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RI02_RS03305	COG1957	nucleoside hydrolase
RI02_RS03310	COG1597	lipid kinase activity
RI02_RS03315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RI02_RS03340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RI02_RS03355	COG1959	2 iron, 2 sulfur cluster binding
RI02_RS03360	COG0492	ferredoxin-NADP+ reductase activity
RI02_RS03375	COG1486	melibiose metabolic process
RI02_RS03385	COG2211	Major facilitator Superfamily
RI02_RS03415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RI02_RS03420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RI02_RS03425	COG1442	glycosyl transferase family 8
RI02_RS03430	COG1216	Glycosyl transferase, family 2
RI02_RS03435	COG1442	glycosyl transferase family 8
RI02_RS03440	COG2223	nitrite transmembrane transporter activity
RI02_RS03450	COG0471	metal ion transport
RI02_RS03465	COG0071	Belongs to the small heat shock protein (HSP20) family
RI02_RS03480	COG0531	amino acid
RI02_RS03485	COG0457	Tetratricopeptide repeat
RI02_RS03485	COG0463	Glycosyl transferase, family 2
RI02_RS03490	COG0488	(ABC) transporter
RI02_RS03495	COG1469	GTP cyclohydrolase I activity
RI02_RS03500	COG0789	Transcriptional regulator
RI02_RS03505	COG2814	Major facilitator Superfamily
RI02_RS03510	COG0488	(ABC) transporter
RI02_RS03515	COG0513	Belongs to the DEAD box helicase family
RI02_RS03520	COG2130	NADP-dependent
RI02_RS03540	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RI02_RS03540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RI02_RS03545	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RI02_RS03555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RI02_RS03555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RI02_RS03565	COG3290	protein histidine kinase activity
RI02_RS03570	COG4565	transcriptional regulatory protein
RI02_RS03575	COG3181	Tripartite tricarboxylate transporter family receptor
RI02_RS03580	COG2851	Citrate transporter
RI02_RS03590	COG3479	Phenolic acid decarboxylase
RI02_RS03595	COG1695	Transcriptional regulator
RI02_RS03600	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
RI02_RS03610	COG1254	Belongs to the acylphosphatase family
RI02_RS03615	COG2258	MOSC domain
RI02_RS03630	COG0024	Methionine aminopeptidase
RI02_RS03635	COG1263	PTS System
RI02_RS03635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RI02_RS03640	COG3739	integral membrane protein
RI02_RS03655	COG1368	sulfuric ester hydrolase activity
RI02_RS03660	COG0076	glutamate decarboxylase activity
RI02_RS03675	COG1263	PTS System
RI02_RS03675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RI02_RS03680	COG0366	Alpha amylase catalytic
RI02_RS03685	COG2188	Transcriptional regulator
RI02_RS03695	COG0737	Belongs to the 5'-nucleotidase family
RI02_RS03700	COG0693	protein deglycase activity
RI02_RS03705	COG4840	Belongs to the UPF0435 family
RI02_RS03710	COG1115	amino acid carrier protein
RI02_RS03715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RI02_RS03720	COG4980	gas vesicle protein
RI02_RS03725	COG1295	ribonuclease BN
RI02_RS03730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RI02_RS03735	COG0477	Major facilitator Superfamily
RI02_RS03745	COG0387	Pfam Sodium calcium exchanger
RI02_RS03755	COG0217	transcriptional regulatory protein
RI02_RS03765	COG0668	transmembrane transport
RI02_RS03770	COG0535	radical SAM domain protein
RI02_RS03780	COG0726	polysaccharide deacetylase
RI02_RS03790	COG0598	Magnesium transport protein CorA
RI02_RS03800	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
RI02_RS03805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RI02_RS03825	COG0789	Transcriptional regulator
RI02_RS03830	COG2814	Major facilitator Superfamily
RI02_RS03880	COG2076	Multidrug Resistance protein
RI02_RS03885	COG2076	Multidrug Resistance protein
RI02_RS03890	COG1309	transcriptional regulator
RI02_RS03900	COG4637	Psort location Cytoplasmic, score
RI02_RS03905	COG2755	lipolytic protein G-D-S-L family
RI02_RS03910	COG0492	ferredoxin-NADP+ reductase activity
RI02_RS03915	COG2169	Transcriptional regulator
RI02_RS03920	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RI02_RS03925	COG1132	(ABC) transporter
RI02_RS03930	COG1742	UPF0060 membrane protein
RI02_RS03935	COG1595	DNA-templated transcription, initiation
RI02_RS03955	COG2318	DinB family
RI02_RS03965	COG1846	Transcriptional regulator
RI02_RS03970	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
RI02_RS03970	COG0392	lysyltransferase activity
RI02_RS03990	COG0778	Nitroreductase
RI02_RS04005	COG1090	epimerase
RI02_RS04010	COG2137	regulation of response to DNA damage stimulus
RI02_RS04035	COG0463	Glycosyl transferase, family 2
RI02_RS04040	COG4485	Bacterial membrane protein, YfhO
RI02_RS04045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RI02_RS04060	COG2140	Oxalate decarboxylase
RI02_RS04070	COG1191	sigma factor activity
RI02_RS04080	COG1988	membrane-bound metal-dependent
RI02_RS04085	COG1194	a g-specific adenine glycosylase
RI02_RS04095	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS04110	COG3557	Belongs to the UPF0374 family
RI02_RS04115	COG1132	(ABC) transporter
RI02_RS04120	COG0444	Belongs to the ABC transporter superfamily
RI02_RS04125	COG4608	Belongs to the ABC transporter superfamily
RI02_RS04130	COG0747	negative chemotaxis
RI02_RS04135	COG0601	transmembrane transport
RI02_RS04140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RI02_RS04145	COG4129	membrane
RI02_RS04150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RI02_RS04155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RI02_RS04160	COG0735	belongs to the Fur family
RI02_RS04305	COG1368	sulfuric ester hydrolase activity
RI02_RS04310	COG0681	Belongs to the peptidase S26 family
RI02_RS04315	COG2873	o-acetylhomoserine
RI02_RS04325	COG1116	anion transmembrane transporter activity
RI02_RS04330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RI02_RS04335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RI02_RS04350	COG1131	(ABC) transporter
RI02_RS04380	COG3382	B3 4 domain protein
RI02_RS04385	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RI02_RS04395	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RI02_RS04400	COG2766	serine protein kinase
RI02_RS04405	COG2718	Belongs to the UPF0229 family
RI02_RS04410	COG1566	PFAM secretion protein HlyD family protein
RI02_RS04415	COG2814	Major facilitator Superfamily
RI02_RS04420	COG0655	NAD(P)H dehydrogenase (quinone) activity
RI02_RS04430	COG1278	Cold shock
RI02_RS04435	COG3706	GGDEF domain
RI02_RS04460	COG5577	PFAM Coat F domain
RI02_RS04465	COG5002	protein histidine kinase activity
RI02_RS04470	COG4085	toxin activity
RI02_RS04470	COG0737	Belongs to the 5'-nucleotidase family
RI02_RS04470	COG1525	nuclease
RI02_RS04475	COG3764	Sortase (surface protein transpeptidase)
RI02_RS04480	COG0564	pseudouridine synthase activity
RI02_RS04490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RI02_RS04495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RI02_RS04495	COG3153	acetyltransferase
RI02_RS04515	COG3835	regulator
RI02_RS04520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RI02_RS04525	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
RI02_RS04530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RI02_RS04535	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RI02_RS04540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RI02_RS04545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RI02_RS04550	COG4585	Histidine kinase
RI02_RS04550	COG2203	Gaf domain
RI02_RS04555	COG2197	response regulator
RI02_RS04570	COG0753	catalase activity
RI02_RS04575	COG1959	2 iron, 2 sulfur cluster binding
RI02_RS04580	COG1017	nitric oxide dioxygenase activity
RI02_RS04580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RI02_RS04585	COG2719	SpoVR family
RI02_RS04590	COG1785	Belongs to the alkaline phosphatase family
RI02_RS04595	COG0791	NLP P60 protein
RI02_RS04595	COG1388	LysM domain
RI02_RS04600	COG0531	amino acid
RI02_RS04615	COG1595	DNA-templated transcription, initiation
RI02_RS04620	COG0204	Acyl-transferase
RI02_RS04625	COG1253	flavin adenine dinucleotide binding
RI02_RS04630	COG0789	Transcriptional regulator
RI02_RS04635	COG1253	flavin adenine dinucleotide binding
RI02_RS04650	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RI02_RS04655	COG0584	glycerophosphoryl diester phosphodiesterase
RI02_RS04665	COG0668	transmembrane transport
RI02_RS04670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RI02_RS04675	COG0726	polysaccharide deacetylase
RI02_RS04680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RI02_RS04685	COG0589	response to stress
RI02_RS04690	COG1132	(ABC) transporter
RI02_RS04695	COG1132	(ABC) transporter
RI02_RS04700	COG0702	epimerase
RI02_RS04710	COG3842	ATPase activity
RI02_RS04715	COG2508	Transcriptional regulator
RI02_RS04725	COG0189	ligase activity
RI02_RS04730	COG0189	ligase activity
RI02_RS04735	COG4399	Belongs to the UPF0754 family
RI02_RS04740	COG3679	Belongs to the UPF0342 family
RI02_RS04745	COG0561	phosphatase activity
RI02_RS04750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RI02_RS04760	COG0475	glutathione-regulated potassium exporter activity
RI02_RS04765	COG0490	domain, Protein
RI02_RS04775	COG1024	Enoyl-CoA hydratase
RI02_RS04785	COG0420	3'-5' exonuclease activity
RI02_RS04790	COG4717	serine-type aminopeptidase activity
RI02_RS04795	COG3481	metal-dependent phosphohydrolase, HD sub domain
RI02_RS04805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RI02_RS04830	COG1846	Transcriptional regulator
RI02_RS04835	COG4980	gas vesicle protein
RI02_RS04850	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RI02_RS04855	COG0537	adenosine 5'-monophosphoramidase activity
RI02_RS04860	COG1131	(ABC) transporter
RI02_RS04865	COG4473	ABC transporter
RI02_RS04875	COG1473	amidohydrolase
RI02_RS04885	COG2329	Antibiotic biosynthesis monooxygenase
RI02_RS04890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RI02_RS04895	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RI02_RS04900	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RI02_RS04905	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
RI02_RS04910	COG1309	transcriptional regulator
RI02_RS04915	COG1511	domain protein
RI02_RS04920	COG1363	Peptidase, m42
RI02_RS04925	COG1301	dicarboxylic acid transport
RI02_RS04935	COG1234	tRNA 3'-trailer cleavage
RI02_RS04940	COG0095	Lipoate-protein ligase
RI02_RS04945	COG0318	PFAM AMP-dependent synthetase and ligase
RI02_RS04955	COG0501	Belongs to the peptidase M48B family
RI02_RS04960	COG1404	Belongs to the peptidase S8 family
RI02_RS04965	COG0406	alpha-ribazole phosphatase activity
RI02_RS04970	COG0840	transmembrane signaling receptor activity
RI02_RS04975	COG0723	plastoquinol--plastocyanin reductase activity
RI02_RS04975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RI02_RS04980	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS04990	COG4903	ComK protein
RI02_RS05005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RI02_RS05010	COG2814	Major facilitator Superfamily
RI02_RS05015	COG2732	(Barnase) inhibitor
RI02_RS05020	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RI02_RS05025	COG4605	iron ion homeostasis
RI02_RS05030	COG4604	ABC transporter, ATP-binding protein
RI02_RS05035	COG4607	ABC-type enterochelin transport system periplasmic component
RI02_RS05040	COG1316	TRANSCRIPTIONal
RI02_RS05055	COG0398	Pfam SNARE associated Golgi protein
RI02_RS05060	COG0681	Belongs to the peptidase S26 family
RI02_RS05070	COG3180	Ammonia monooxygenase
RI02_RS05085	COG2259	Doxx family
RI02_RS05090	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
RI02_RS05095	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
RI02_RS05100	COG1074	ATP-dependent DNA helicase activity
RI02_RS05105	COG0420	3'-5' exonuclease activity
RI02_RS05110	COG0419	ATPase involved in DNA repair
RI02_RS05115	COG1403	HNH endonuclease
RI02_RS05155	COG5337	Spore coat protein CotH
RI02_RS05165	COG0179	Fumarylacetoacetate (FAA) hydrolase
RI02_RS05180	COG0367	asparagine synthase
RI02_RS05195	COG1562	ergosterol biosynthetic process
RI02_RS05200	COG0534	Mate efflux family protein
RI02_RS05205	COG1917	Cupin 2, conserved barrel domain protein
RI02_RS05205	COG2207	Transcriptional regulator
RI02_RS05230	COG0076	glutamate decarboxylase activity
RI02_RS05265	COG0646	methionine synthase
RI02_RS05265	COG1410	methionine synthase
RI02_RS05270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RI02_RS05270	COG0646	methionine synthase
RI02_RS05275	COG1666	GTP binding
RI02_RS05280	COG2996	Protein conserved in bacteria
RI02_RS05285	COG1744	ABC transporter substrate-binding protein PnrA-like
RI02_RS05290	COG0840	transmembrane signaling receptor activity
RI02_RS05295	COG1307	EDD domain protein, DegV family
RI02_RS05300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RI02_RS05320	COG0561	phosphatase activity
RI02_RS05325	COG1073	alpha beta
RI02_RS05330	COG2151	metal-sulfur cluster biosynthetic enzyme
RI02_RS05335	COG0277	FAD linked oxidase domain protein
RI02_RS05340	COG2271	Major facilitator Superfamily
RI02_RS05345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RI02_RS05350	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RI02_RS05355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RI02_RS05360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RI02_RS05365	COG0505	Belongs to the CarA family
RI02_RS05370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RI02_RS05375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RI02_RS05385	COG2814	Major facilitator Superfamily
RI02_RS05395	COG2267	carboxylic ester hydrolase activity
RI02_RS05405	COG1744	ABC transporter substrate-binding protein PnrA-like
RI02_RS05420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RI02_RS05425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RI02_RS05430	COG5504	Zn-dependent protease
RI02_RS05435	COG0444	Belongs to the ABC transporter superfamily
RI02_RS05440	COG4608	Belongs to the ABC transporter superfamily
RI02_RS05450	COG0601	transmembrane transport
RI02_RS05455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RI02_RS05465	COG0180	Tryptophanyl-tRNA synthetase
RI02_RS05470	COG4166	transmembrane transport
RI02_RS05475	COG0601	transmembrane transport
RI02_RS05480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RI02_RS05485	COG0444	Belongs to the ABC transporter superfamily
RI02_RS05490	COG4608	Belongs to the ABC transporter superfamily
RI02_RS05500	COG0456	acetyltransferase
RI02_RS05505	COG1393	Belongs to the ArsC family
RI02_RS05510	COG0861	Integral membrane protein TerC family
RI02_RS05515	COG4862	establishment of competence for transformation
RI02_RS05520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RI02_RS05530	COG1164	Oligoendopeptidase f
RI02_RS05540	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
RI02_RS05545	COG2346	COG2346, Truncated hemoglobins
RI02_RS05550	COG0741	lytic transglycosylase activity
RI02_RS05555	COG4116	CYTH
RI02_RS05565	COG2357	RelA SpoT domain protein
RI02_RS05570	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RI02_RS05575	COG0564	pseudouridine synthase activity
RI02_RS05580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RI02_RS05585	COG0569	domain protein
RI02_RS05585	COG0475	glutathione-regulated potassium exporter activity
RI02_RS05590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RI02_RS05595	COG0352	thiamine-phosphate diphosphorylase activity
RI02_RS05605	COG2104	thiamine diphosphate biosynthetic process
RI02_RS05610	COG2022	thiamine diphosphate biosynthetic process
RI02_RS05615	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RI02_RS05620	COG0351	phosphomethylpyrimidine kinase
RI02_RS05625	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RI02_RS05680	COG0210	DNA helicase
RI02_RS05690	COG2153	protein acetylation
RI02_RS05695	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
RI02_RS05700	COG2382	esterase
RI02_RS05705	COG0626	cystathionine gamma-synthase activity
RI02_RS05710	COG0626	cystathionine gamma-synthase activity
RI02_RS05720	COG3620	sequence-specific DNA binding
RI02_RS05735	COG0825	malonyl-CoA metabolic process
RI02_RS05750	COG0457	Tetratricopeptide repeat
RI02_RS05760	COG1280	lysine exporter protein (LysE YggA)
RI02_RS05770	COG2364	Membrane
RI02_RS05805	COG3173	Aminoglycoside phosphotransferase
RI02_RS05810	COG0583	DNA-binding transcription factor activity
RI02_RS05830	COG0583	DNA-binding transcription factor activity
RI02_RS05835	COG2807	transmembrane transport
RI02_RS05865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RI02_RS05875	COG1309	transcriptional regulator
RI02_RS05885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RI02_RS05890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RI02_RS05895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RI02_RS05900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RI02_RS05920	COG4195	phage-related replication protein
RI02_RS05925	COG2856	Zn peptidase
RI02_RS05930	COG5632	N-Acetylmuramoyl-L-alanine amidase
RI02_RS05930	COG3409	Peptidoglycan-binding domain 1 protein
RI02_RS05945	COG0306	phosphate transporter
RI02_RS05950	COG1392	Phosphate transport regulator
RI02_RS05960	COG0405	Gamma-glutamyltransferase
RI02_RS05965	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RI02_RS05975	COG4208	sulfate ABC transporter
RI02_RS05980	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RI02_RS05990	COG3775	system Galactitol-specific IIC component
RI02_RS06005	COG1063	alcohol dehydrogenase
RI02_RS06010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RI02_RS06015	COG0508	dehydrogenase complex catalyzes the overall conversion of
RI02_RS06015	COG0022	dehydrogenase e1 component
RI02_RS06020	COG0508	dehydrogenase complex catalyzes the overall conversion of
RI02_RS06025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RI02_RS06030	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS06035	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS06040	COG2390	Transcriptional regulator
RI02_RS06050	COG0531	amino acid
RI02_RS06055	COG0346	lactoylglutathione lyase activity
RI02_RS06060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RI02_RS06065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RI02_RS06070	COG2362	D-Aminopeptidase
RI02_RS06075	COG0601	transmembrane transport
RI02_RS06080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RI02_RS06085	COG0444	Belongs to the ABC transporter superfamily
RI02_RS06090	COG4166	transmembrane transport
RI02_RS06095	COG1619	proteins homologs of microcin C7 resistance protein MccF
RI02_RS06100	COG4948	Mandelate Racemase Muconate Lactonizing
RI02_RS06105	COG0791	NLP P60 protein
RI02_RS06110	COG4608	Belongs to the ABC transporter superfamily
RI02_RS06115	COG1834	amidinotransferase
RI02_RS06120	COG1607	acyl-coa hydrolase
RI02_RS06125	COG1695	Transcriptional regulator
RI02_RS06140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RI02_RS06150	COG2076	Multidrug Resistance protein
RI02_RS06155	COG2076	Multidrug Resistance protein
RI02_RS06165	COG0788	formyltetrahydrofolate deformylase activity
RI02_RS06170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RI02_RS06175	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RI02_RS06180	COG0457	Tetratricopeptide repeat
RI02_RS06190	COG1764	response to oxidative stress
RI02_RS06195	COG1846	Transcriptional regulator
RI02_RS06200	COG1764	response to oxidative stress
RI02_RS06205	COG0590	tRNA wobble adenosine to inosine editing
RI02_RS06210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RI02_RS06215	COG1404	Belongs to the peptidase S8 family
RI02_RS06230	COG0745	RESPONSE REGULATOR receiver
RI02_RS06235	COG5002	protein histidine kinase activity
RI02_RS06235	COG3850	Histidine kinase
RI02_RS06240	COG3212	peptidase
RI02_RS06245	COG3212	peptidase
RI02_RS06255	COG2239	Acts as a magnesium transporter
RI02_RS06265	COG0583	DNA-binding transcription factor activity
RI02_RS06275	COG0789	Transcriptional regulator
RI02_RS06290	COG1846	Transcriptional regulator
RI02_RS06295	COG3300	MHYT domain
RI02_RS06295	COG5001	Diguanylate cyclase
RI02_RS06300	COG0586	Pfam SNARE associated Golgi protein
RI02_RS06305	COG0861	Integral membrane protein TerC family
RI02_RS06310	COG1191	sigma factor activity
RI02_RS06330	COG0501	Belongs to the peptidase M48B family
RI02_RS06335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RI02_RS06340	COG2323	membrane
RI02_RS06355	COG3594	Acyltransferase
RI02_RS06360	COG5002	protein histidine kinase activity
RI02_RS06365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RI02_RS06370	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
RI02_RS06375	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
RI02_RS06380	COG0436	Aminotransferase
RI02_RS06385	COG1850	ribulose-bisphosphate carboxylase activity
RI02_RS06390	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
RI02_RS06395	COG0235	Class ii aldolase
RI02_RS06400	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
RI02_RS06410	COG3852	Histidine kinase
RI02_RS06415	COG1846	Transcriptional regulator
RI02_RS06420	COG1360	Flagellar Motor Protein
RI02_RS06425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RI02_RS06430	COG0542	response to heat
RI02_RS06440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RI02_RS06445	COG0720	synthase
RI02_RS06450	COG0602	queuosine metabolic process
RI02_RS06455	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RI02_RS06465	COG4873	Protein conserved in bacteria
RI02_RS06475	COG3773	Cell wall hydrolase
RI02_RS06480	COG2244	polysaccharide biosynthetic process
RI02_RS06485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RI02_RS06490	COG2217	Heavy metal translocating P-type atpase
RI02_RS06495	COG0006	proline dipeptidase activity
RI02_RS06500	COG1609	Transcriptional regulator
RI02_RS06505	COG3711	transcriptional antiterminator
RI02_RS06510	COG1263	PTS System
RI02_RS06510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RI02_RS06510	COG2190	(PTS) system
RI02_RS06515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RI02_RS06520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RI02_RS06530	COG1533	DNA photolyase activity
RI02_RS06535	COG0840	transmembrane signaling receptor activity
RI02_RS06545	COG2084	Dehydrogenase
RI02_RS06550	COG2340	Cysteine-rich secretory protein family
RI02_RS06555	COG0768	penicillin binding
RI02_RS06565	COG0436	Aminotransferase
RI02_RS06570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RI02_RS06580	COG1714	RDD family
RI02_RS06590	COG0835	chemotaxis
RI02_RS06590	COG0784	Response regulator, receiver
RI02_RS06600	COG2207	Transcriptional regulator
RI02_RS06600	COG1917	Cupin 2, conserved barrel domain protein
RI02_RS06605	COG0697	spore germination
RI02_RS06620	COG2814	Major facilitator Superfamily
RI02_RS06625	COG1376	ErfK ybiS ycfS ynhG family protein
RI02_RS06630	COG1408	metallophosphoesterase
RI02_RS06635	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS06640	COG2200	EAL domain
RI02_RS06645	COG3546	catalase activity
RI02_RS06650	COG4703	Protein of unknown function (DUF1797)
RI02_RS06655	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
RI02_RS06665	COG0517	IMP dehydrogenase activity
RI02_RS06670	COG0583	DNA-binding transcription factor activity
RI02_RS06680	COG0716	FMN binding
RI02_RS06690	COG0716	FMN binding
RI02_RS06695	COG2171	N-acyltransferase activity
RI02_RS06700	COG1473	amidohydrolase
RI02_RS06710	COG0668	transmembrane transport
RI02_RS06715	COG0450	alkyl hydroperoxide reductase
RI02_RS06720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RI02_RS06735	COG0746	molybdenum cofactor guanylyltransferase activity
RI02_RS06740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RI02_RS06745	COG0303	'Molybdopterin
RI02_RS06750	COG1763	Mo-molybdopterin cofactor biosynthetic process
RI02_RS06755	COG0314	molybdopterin synthase activity
RI02_RS06760	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RI02_RS06775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RI02_RS06780	COG1136	(ABC) transporter
RI02_RS06785	COG0577	efflux transmembrane transporter activity
RI02_RS06790	COG1349	DNA-binding transcription factor activity
RI02_RS06795	COG1105	Belongs to the carbohydrate kinase PfkB family
RI02_RS06800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RI02_RS06800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RI02_RS06800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RI02_RS06805	COG0681	Belongs to the peptidase S26 family
RI02_RS06815	COG0488	(ABC) transporter
RI02_RS06825	COG2309	aminopeptidase activity
RI02_RS06835	COG1077	Cell shape determining protein MreB Mrl
RI02_RS06840	COG2002	toxin-antitoxin pair type II binding
RI02_RS06845	COG3852	Histidine kinase
RI02_RS06850	COG2105	PFAM AIG2 family protein
RI02_RS06850	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
RI02_RS06855	COG0569	domain protein
RI02_RS06860	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RI02_RS06865	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RI02_RS06870	COG5503	Protein of unknown function (DUF1447)
RI02_RS06875	COG0561	phosphatase activity
RI02_RS06880	COG0242	peptide deformylase activity
RI02_RS06895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RI02_RS06900	COG0022	dehydrogenase e1 component
RI02_RS06905	COG0508	dehydrogenase complex catalyzes the overall conversion of
RI02_RS06910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RI02_RS06915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RI02_RS06925	COG1982	Orn Lys Arg decarboxylase major
RI02_RS06930	COG4476	Belongs to the UPF0223 family
RI02_RS06935	COG4493	Belongs to the UPF0637 family
RI02_RS06945	COG0483	inositol monophosphate 1-phosphatase activity
RI02_RS06960	COG1595	DNA-templated transcription, initiation
RI02_RS06980	COG1217	gtp-binding protein TYPA
RI02_RS06990	COG4896	Protein conserved in bacteria
RI02_RS07000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RI02_RS07005	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RI02_RS07010	COG2066	Belongs to the glutaminase family
RI02_RS07015	COG4838	Belongs to the UPF0358 family
RI02_RS07020	COG0772	Belongs to the SEDS family
RI02_RS07025	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
RI02_RS07030	COG0415	Belongs to the DNA photolyase family
RI02_RS07035	COG1612	heme a metabolic process
RI02_RS07040	COG0109	protoheme IX farnesyltransferase activity
RI02_RS07045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RI02_RS07045	COG2010	Cytochrome c
RI02_RS07050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RI02_RS07055	COG1845	cytochrome c oxidase, subunit III
RI02_RS07060	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RI02_RS07065	COG3336	cytochrome c oxidase
RI02_RS07075	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
RI02_RS07080	COG2340	Cysteine-rich secretory protein family
RI02_RS07100	COG3679	Belongs to the UPF0342 family
RI02_RS07105	COG4471	UPF0298 protein
RI02_RS07110	COG0742	ribosomal rna small subunit methyltransferase
RI02_RS07115	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RI02_RS07120	COG3314	Sporulation integral membrane protein YlbJ
RI02_RS07125	COG1752	Esterase of the alpha-beta hydrolase superfamily
RI02_RS07130	COG3480	Lon protease (S16) C-terminal proteolytic domain
RI02_RS07140	COG1399	metal-binding, possibly nucleic acid-binding protein
RI02_RS07145	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RI02_RS07155	COG0454	-acetyltransferase
RI02_RS07160	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RI02_RS07165	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
RI02_RS07170	COG2001	Belongs to the MraZ family
RI02_RS07175	COG0275	rRNA processing
RI02_RS07180	COG4839	cell division protein FtsL
RI02_RS07185	COG0768	penicillin binding
RI02_RS07190	COG0768	penicillin binding
RI02_RS07195	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RI02_RS07200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RI02_RS07205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RI02_RS07210	COG0772	Belongs to the SEDS family
RI02_RS07215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RI02_RS07220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RI02_RS07225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RI02_RS07230	COG3879	Bacterial protein of unknown function (DUF881)
RI02_RS07235	COG3879	Bacterial protein of unknown function (DUF881)
RI02_RS07240	COG3856	small basic protein
RI02_RS07245	COG0849	cell division
RI02_RS07250	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RI02_RS07255	COG4412	M6 family metalloprotease domain protein
RI02_RS07255	COG1404	Belongs to the peptidase S8 family
RI02_RS07265	COG1191	sigma factor activity
RI02_RS07270	COG1191	sigma factor activity
RI02_RS07275	COG2390	Transcriptional regulator
RI02_RS07290	COG3730	PTS system glucitol sorbitol-specific
RI02_RS07295	COG3732	PTS system glucitol sorbitol-specific
RI02_RS07305	COG1119	ATPase activity
RI02_RS07310	COG1873	PFAM PRC-barrel domain
RI02_RS07315	COG1496	oxidoreductase activity
RI02_RS07320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RI02_RS07325	COG1799	cell septum assembly
RI02_RS07330	COG0762	integral membrane protein
RI02_RS07335	COG2302	S4 RNA-binding domain
RI02_RS07340	COG3599	regulation of cell shape
RI02_RS07345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RI02_RS07350	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RI02_RS07355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RI02_RS07360	COG0564	pseudouridine synthase activity
RI02_RS07365	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RI02_RS07370	COG2233	PERMEase
RI02_RS07375	COG0540	Belongs to the ATCase OTCase family
RI02_RS07380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RI02_RS07385	COG0505	Belongs to the CarA family
RI02_RS07390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RI02_RS07395	COG0543	2 iron, 2 sulfur cluster binding
RI02_RS07400	COG0167	dihydroorotate dehydrogenase activity
RI02_RS07405	COG0284	orotidine-5'-phosphate decarboxylase activity
RI02_RS07410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RI02_RS07420	COG0175	sulfate reduction
RI02_RS07425	COG0306	phosphate transporter
RI02_RS07430	COG2046	Belongs to the sulfate adenylyltransferase family
RI02_RS07435	COG0529	Catalyzes the synthesis of activated sulfate
RI02_RS07440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RI02_RS07445	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
RI02_RS07450	COG1648	precorrin-2 dehydrogenase activity
RI02_RS07460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RI02_RS07465	COG1561	YicC-like family, N-terminal region
RI02_RS07470	COG2052	Domain of unknown function (DUF370)
RI02_RS07475	COG0194	GDP metabolic process
RI02_RS07480	COG1758	RNA polymerase activity
RI02_RS07485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RI02_RS07490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RI02_RS07495	COG0242	peptide deformylase activity
RI02_RS07500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RI02_RS07505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RI02_RS07505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RI02_RS07510	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RI02_RS07515	COG0631	protein serine/threonine phosphatase activity
RI02_RS07520	COG2815	serine threonine protein kinase
RI02_RS07520	COG0515	serine threonine protein kinase
RI02_RS07525	COG1162	GTPase activity
RI02_RS07530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RI02_RS07535	COG1564	THIamine pyrophosphokinase
RI02_RS07545	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RI02_RS07550	COG1302	Protein conserved in bacteria
RI02_RS07555	COG1461	Dihydroxyacetone kinase
RI02_RS07560	COG1760	l-serine dehydratase
RI02_RS07565	COG1760	l-serine dehydratase
RI02_RS07570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RI02_RS07575	COG1349	DNA-binding transcription factor activity
RI02_RS07580	COG0416	fatty acid biosynthetic process
RI02_RS07585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RI02_RS07590	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS07595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RI02_RS07605	COG1196	nuclear chromosome segregation
RI02_RS07610	COG0552	protein localization to endoplasmic reticulum
RI02_RS07615	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
RI02_RS07620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RI02_RS07625	COG0228	four-way junction DNA binding
RI02_RS07630	COG1837	Belongs to the UPF0109 family
RI02_RS07640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RI02_RS07645	COG0336	Belongs to the RNA methyltransferase TrmD family
RI02_RS07650	COG0335	large ribosomal subunit rRNA binding
RI02_RS07655	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RI02_RS07660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RI02_RS07670	COG2257	FlhB HrpN YscU SpaS Family
RI02_RS07675	COG0045	succinate-CoA ligase (ADP-forming) activity
RI02_RS07680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RI02_RS07685	COG0758	DNA mediated transformation
RI02_RS07690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RI02_RS07695	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
RI02_RS07700	COG4974	Belongs to the 'phage' integrase family
RI02_RS07705	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RI02_RS07710	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RI02_RS07715	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
RI02_RS07720	COG1815	bacterial-type flagellum-dependent cell motility
RI02_RS07725	COG1558	bacterial-type flagellum-dependent cell motility
RI02_RS07730	COG1677	Flagellar hook-basal body complex protein FliE
RI02_RS07735	COG1766	The M ring may be actively involved in energy transduction
RI02_RS07740	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RI02_RS07745	COG1317	bacterial-type flagellum organization
RI02_RS07750	COG1157	protein secretion by the type III secretion system
RI02_RS07755	COG2882	bacterial-type flagellum organization
RI02_RS07760	COG3334	PFAM MgtE intracellular
RI02_RS07765	COG3144	bacterial-type flagellum assembly
RI02_RS07770	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RI02_RS07775	COG4786	Flagellar basal body rod
RI02_RS07780	COG1582	Flagellar protein (FlbD)
RI02_RS07785	COG1580	Controls the rotational direction of flagella during chemotaxis
RI02_RS07790	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RI02_RS07795	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RI02_RS07795	COG1776	CheC inhibitor of MCP methylation
RI02_RS07800	COG2201	protein-glutamate methylesterase activity
RI02_RS07805	COG3190	flagellar
RI02_RS07810	COG1338	Plays a role in the flagellum-specific transport system
RI02_RS07815	COG1987	bacterial-type flagellum assembly
RI02_RS07820	COG1684	flagellar biosynthetic protein fliR
RI02_RS07825	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RI02_RS07830	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RI02_RS07835	COG1419	protein localization to endoplasmic reticulum
RI02_RS07840	COG0455	bacterial-type flagellum organization
RI02_RS07845	COG2201	protein-glutamate methylesterase activity
RI02_RS07850	COG0643	Histidine kinase
RI02_RS07850	COG2198	Histidine kinase
RI02_RS07855	COG0835	chemotaxis
RI02_RS07860	COG1776	CheC inhibitor of MCP methylation
RI02_RS07870	COG1191	sigma factor activity
RI02_RS07885	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RI02_RS07890	COG0528	UMP kinase activity
RI02_RS07895	COG0233	cytoplasmic translational termination
RI02_RS07900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RI02_RS07905	COG4589	Belongs to the CDS family
RI02_RS07910	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RI02_RS07915	COG0750	zinc metalloprotease
RI02_RS07920	COG0442	prolyl-tRNA aminoacylation
RI02_RS07925	COG2176	DNA-directed DNA polymerase activity
RI02_RS07940	COG3693	PFAM glycoside hydrolase, family 10
RI02_RS07950	COG0779	Required for maturation of 30S ribosomal subunits
RI02_RS07955	COG0195	Participates in both transcription termination and antitermination
RI02_RS07960	COG2740	Nucleic-acid-binding protein implicated in transcription termination
RI02_RS07965	COG1358	cellular component organization or biogenesis
RI02_RS07970	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RI02_RS07975	COG1550	Protein conserved in bacteria
RI02_RS07980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RI02_RS07985	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RI02_RS07990	COG0196	riboflavin kinase activity
RI02_RS07995	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RI02_RS08000	COG1185	polyribonucleotide nucleotidyltransferase activity
RI02_RS08005	COG0726	polysaccharide deacetylase
RI02_RS08010	COG0612	Peptidase, M16
RI02_RS08020	COG1873	PFAM PRC-barrel domain
RI02_RS08025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RI02_RS08030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RI02_RS08035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RI02_RS08040	COG0527	aspartate kinase activity
RI02_RS08050	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RI02_RS08055	COG0740	serine-type endopeptidase activity
RI02_RS08065	COG4980	gas vesicle protein
RI02_RS08065	COG1674	ftsk spoiiie
RI02_RS08070	COG2188	Transcriptional regulator
RI02_RS08075	COG2814	Major facilitator Superfamily
RI02_RS08080	COG2409	Drug exporters of the RND superfamily
RI02_RS08080	COG1033	growth of symbiont in host cell
RI02_RS08085	COG0612	Peptidase, M16
RI02_RS08090	COG0612	Peptidase, M16
RI02_RS08100	COG2409	Drug exporters of the RND superfamily
RI02_RS08100	COG1033	growth of symbiont in host cell
RI02_RS08105	COG0300	oxidoreductase activity
RI02_RS08120	COG1426	Protein conserved in bacteria
RI02_RS08125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RI02_RS08130	COG1058	Belongs to the CinA family
RI02_RS08130	COG1546	Belongs to the CinA family
RI02_RS08135	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RI02_RS08140	COG1418	mRNA catabolic process
RI02_RS08145	COG1692	metallophosphoesterase
RI02_RS08150	COG2359	stage V sporulation protein S
RI02_RS08155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RI02_RS08160	COG1063	alcohol dehydrogenase
RI02_RS08165	COG0156	8-amino-7-oxononanoate synthase activity
RI02_RS08170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RI02_RS08175	COG4550	Control of competence regulator ComK, YlbF/YmcA
RI02_RS08185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RI02_RS08190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RI02_RS08210	COG1329	Transcriptional regulator
RI02_RS08215	COG4195	phage-related replication protein
RI02_RS08220	COG0457	Tetratricopeptide repeat
RI02_RS08225	COG1404	Belongs to the peptidase S8 family
RI02_RS08230	COG4195	phage-related replication protein
RI02_RS08235	COG1764	response to oxidative stress
RI02_RS08265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RI02_RS08270	COG1923	regulation of RNA biosynthetic process
RI02_RS08285	COG1780	Probably involved in ribonucleotide reductase function
RI02_RS08290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RI02_RS08295	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RI02_RS08300	COG4112	unkown
RI02_RS08310	COG0464	growth
RI02_RS08315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RI02_RS08320	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
RI02_RS08325	COG0789	Transcriptional regulator
RI02_RS08330	COG0174	glutamine synthetase
RI02_RS08350	COG0457	Tetratricopeptide repeat
RI02_RS08370	COG5444	nuclease activity
RI02_RS08395	COG5646	InterPro IPR014922
RI02_RS08415	COG0457	Tetratricopeptide repeat
RI02_RS08425	COG3619	membrane
RI02_RS08430	COG1793	dna ligase
RI02_RS08430	COG3285	dna ligase
RI02_RS08435	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
RI02_RS08440	COG4876	unkown
RI02_RS08450	COG1959	2 iron, 2 sulfur cluster binding
RI02_RS08455	COG0702	epimerase
RI02_RS08465	COG0247	lactate metabolic process
RI02_RS08470	COG1139	Iron-sulfur cluster binding protein
RI02_RS08475	COG1556	Lactate utilization protein
RI02_RS08495	COG2323	membrane
RI02_RS08500	COG1309	transcriptional regulator
RI02_RS08505	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RI02_RS08505	COG2124	cytochrome p450
RI02_RS08510	COG3591	Belongs to the peptidase S1B family
RI02_RS08515	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RI02_RS08520	COG3209	COG3209 Rhs family protein
RI02_RS08525	COG1366	Belongs to the anti-sigma-factor antagonist family
RI02_RS08540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RI02_RS08545	COG1388	LysM domain
RI02_RS08550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RI02_RS08555	COG4224	UPF0291 protein
RI02_RS08560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RI02_RS08570	COG3763	UPF0154 protein
RI02_RS08580	COG0785	Cytochrome C biogenesis protein
RI02_RS08585	COG4846	Membrane protein involved in cytochrome C biogenesis
RI02_RS08595	COG0071	Belongs to the small heat shock protein (HSP20) family
RI02_RS08610	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RI02_RS08615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RI02_RS08635	COG0824	Thioesterase
RI02_RS08645	COG4841	protein insertion into membrane
RI02_RS08650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RI02_RS08655	COG1832	CoA-binding protein
RI02_RS08660	COG0187	DNA topoisomerase II activity
RI02_RS08665	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RI02_RS08675	COG0738	Major facilitator superfamily
RI02_RS08680	COG0473	3-isopropylmalate dehydrogenase activity
RI02_RS08690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RI02_RS08695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RI02_RS08700	COG0640	Transcriptional regulator
RI02_RS08710	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
RI02_RS08725	COG1309	transcriptional regulator
RI02_RS08730	COG2249	NAD(P)H dehydrogenase (quinone) activity
RI02_RS08735	COG1733	regulation of RNA biosynthetic process
RI02_RS08740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RI02_RS08745	COG0251	oxidation-reduction process
RI02_RS08785	COG0657	acetylesterase activity
RI02_RS08795	COG2723	6-phospho-beta-galactosidase activity
RI02_RS08800	COG1263	PTS System
RI02_RS08800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RI02_RS08800	COG2190	(PTS) system
RI02_RS08815	COG2205	protein histidine kinase activity
RI02_RS08820	COG0745	RESPONSE REGULATOR receiver
RI02_RS08830	COG3507	Belongs to the glycosyl hydrolase 43 family
RI02_RS08835	COG1012	belongs to the aldehyde dehydrogenase family
RI02_RS08840	COG1486	melibiose metabolic process
RI02_RS08845	COG0395	ABC-type sugar transport system, permease component
RI02_RS08850	COG1175	transmembrane transport
RI02_RS08855	COG1653	transport
RI02_RS08860	COG1609	Transcriptional regulator
RI02_RS08865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RI02_RS08880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RI02_RS08915	COG5444	nuclease activity
RI02_RS08920	COG1846	Transcriptional regulator
RI02_RS08925	COG2814	Major facilitator Superfamily
RI02_RS08935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RI02_RS08935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RI02_RS08935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RI02_RS08940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RI02_RS08940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RI02_RS08940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RI02_RS08945	COG1105	Belongs to the carbohydrate kinase PfkB family
RI02_RS08955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RI02_RS08975	COG1012	belongs to the aldehyde dehydrogenase family
RI02_RS08980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RI02_RS08985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RI02_RS08990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RI02_RS08995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RI02_RS09000	COG1024	Enoyl-CoA hydratase
RI02_RS09005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RI02_RS09010	COG0511	ligase activity, forming carbon-carbon bonds
RI02_RS09015	COG0439	Biotin carboxylase
RI02_RS09020	COG0318	PFAM AMP-dependent synthetase and ligase
RI02_RS09025	COG1960	acyl-CoA dehydrogenase activity
RI02_RS09030	COG1649	PFAM Uncharacterised BCR, COG1649
RI02_RS09035	COG2365	Tyrosine phosphatase family
RI02_RS09040	COG1349	DNA-binding transcription factor activity
RI02_RS09045	COG1942	4-Oxalocrotonate Tautomerase
RI02_RS09055	COG3835	regulator
RI02_RS09060	COG0277	FAD linked oxidase domain protein
RI02_RS09065	COG0247	lactate metabolic process
RI02_RS09085	COG0166	Belongs to the GPI family
RI02_RS09090	COG2246	polysaccharide biosynthetic process
RI02_RS09095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RI02_RS09100	COG0586	Pfam SNARE associated Golgi protein
RI02_RS09105	COG1587	Uroporphyrinogen-III synthase
RI02_RS09115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RI02_RS09130	COG0534	Mate efflux family protein
RI02_RS09135	COG2027	D-alanyl-D-alanine carboxypeptidase
RI02_RS09140	COG4677	pectinesterase activity
RI02_RS09145	COG2323	membrane
RI02_RS09150	COG2146	nitrite reductase [NAD(P)H] activity
RI02_RS09155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RI02_RS09160	COG0243	molybdopterin cofactor binding
RI02_RS09165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RI02_RS09170	COG2223	nitrite transmembrane transporter activity
RI02_RS09175	COG0493	'glutamate synthase
RI02_RS09180	COG0069	glutamate synthase activity
RI02_RS09180	COG0067	glutamate synthase
RI02_RS09180	COG0070	glutamate synthase
RI02_RS09185	COG0583	DNA-binding transcription factor activity
RI02_RS09195	COG1132	(ABC) transporter
RI02_RS09200	COG0789	Transcriptional regulator
RI02_RS09200	COG4978	Transcriptional regulator
RI02_RS09205	COG0454	-acetyltransferase
RI02_RS09210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RI02_RS09215	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RI02_RS09220	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RI02_RS09230	COG0243	molybdopterin cofactor binding
RI02_RS09240	COG1070	Carbohydrate kinase
RI02_RS09245	COG2115	Belongs to the xylose isomerase family
RI02_RS09250	COG1940	carbohydrate kinase activity
RI02_RS09260	COG2211	Major facilitator Superfamily
RI02_RS09265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RI02_RS09270	COG1994	Peptidase M50
RI02_RS09290	COG1309	transcriptional regulator
RI02_RS09295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RI02_RS09300	COG3708	Transcriptional regulator
RI02_RS09305	COG2378	regulation of single-species biofilm formation
RI02_RS09315	COG0640	Transcriptional regulator
RI02_RS09320	COG0531	amino acid
RI02_RS09325	COG0741	lytic transglycosylase activity
RI02_RS09330	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RI02_RS09335	COG2079	MmgE PrpD family protein
RI02_RS09340	COG0372	Belongs to the citrate synthase family
RI02_RS09345	COG2322	membrane
RI02_RS09355	COG3584	3D domain protein
RI02_RS09355	COG1388	LysM domain
RI02_RS09360	COG0514	ATP-dependent DNA helicase (RecQ)
RI02_RS09370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RI02_RS09395	COG1012	belongs to the aldehyde dehydrogenase family
RI02_RS09400	COG1657	PFAM Prenyltransferase squalene oxidase
RI02_RS09405	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RI02_RS09410	COG0385	Bile acid
RI02_RS09415	COG0508	dehydrogenase complex catalyzes the overall conversion of
RI02_RS09420	COG0567	Dehydrogenase, E1 component
RI02_RS09425	COG4548	von Willebrand factor, type A
RI02_RS09430	COG0714	Associated with various cellular activities
RI02_RS09435	COG2032	superoxide dismutase activity
RI02_RS09440	COG0791	NLP P60 protein
RI02_RS09440	COG1388	LysM domain
RI02_RS09445	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
RI02_RS09450	COG0534	Mate efflux family protein
RI02_RS09455	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RI02_RS09460	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RI02_RS09470	COG2962	Rard protein
RI02_RS09485	COG1733	regulation of RNA biosynthetic process
RI02_RS09490	COG0778	Nitroreductase
RI02_RS09500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RI02_RS09505	COG0793	Belongs to the peptidase S41A family
RI02_RS09505	COG3409	Peptidoglycan-binding domain 1 protein
RI02_RS09510	COG2226	methyltransferase
RI02_RS09525	COG1876	peptidase activity
RI02_RS09530	COG0813	purine-nucleoside phosphorylase activity
RI02_RS09540	COG0671	phosphoesterase, PA-phosphatase related
RI02_RS09555	COG4479	Belongs to the UPF0346 family
RI02_RS09565	COG1509	lysine 2,3-aminomutase activity
RI02_RS09570	COG3829	transcription factor binding
RI02_RS09575	COG0463	Glycosyl transferase, family 2
RI02_RS09590	COG4641	Protein conserved in bacteria
RI02_RS09600	COG1086	Polysaccharide biosynthesis protein
RI02_RS09605	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RI02_RS09610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RI02_RS09615	COG1846	Transcriptional regulator
RI02_RS09635	COG4698	Protein conserved in bacteria
RI02_RS09640	COG2755	lipolytic protein G-D-S-L family
RI02_RS09645	COG1999	signal sequence binding
RI02_RS09660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RI02_RS09665	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
RI02_RS09670	COG1272	protein, Hemolysin III
RI02_RS09675	COG0204	Acyl-transferase
RI02_RS09680	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RI02_RS09685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RI02_RS09690	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RI02_RS09700	COG2521	methyltransferase
RI02_RS09700	COG2136	Putative SAM-dependent methyltransferase
RI02_RS09710	COG0129	dihydroxy-acid dehydratase activity
RI02_RS09715	COG1413	lyase activity
RI02_RS09720	COG1418	mRNA catabolic process
RI02_RS09725	COG0386	Belongs to the glutathione peroxidase family
RI02_RS09730	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RI02_RS09735	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
RI02_RS09740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RI02_RS09750	COG1278	Cold shock
RI02_RS09765	COG0328	RNA-DNA hybrid ribonuclease activity
RI02_RS09770	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RI02_RS09775	COG0328	RNA-DNA hybrid ribonuclease activity
RI02_RS09785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RI02_RS09795	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
RI02_RS09805	COG1755	Isoprenylcysteine carboxyl methyltransferase
RI02_RS09810	COG3424	synthase
RI02_RS09815	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
RI02_RS09815	COG0456	acetyltransferase
RI02_RS09820	COG0726	polysaccharide deacetylase
RI02_RS09825	COG2233	PERMEase
RI02_RS09830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RI02_RS09835	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
RI02_RS09840	COG1199	ATP-dependent helicase activity
RI02_RS09850	COG0116	Belongs to the methyltransferase superfamily
RI02_RS09860	COG3599	regulation of cell shape
RI02_RS09865	COG4474	Belongs to the UPF0398 family
RI02_RS09875	COG3359	exonuclease
RI02_RS09880	COG1205	dead DEAH box helicase
RI02_RS09880	COG1111	helicase
RI02_RS09885	COG1902	pentaerythritol trinitrate reductase activity
RI02_RS09890	COG2190	(PTS) system
RI02_RS09895	COG0071	Belongs to the small heat shock protein (HSP20) family
RI02_RS09925	COG3331	DNA recombination
RI02_RS09930	COG4499	WXG100 protein secretion system (Wss), protein YukC
RI02_RS09930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RI02_RS09940	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RI02_RS09945	COG3935	DnaD domain protein
RI02_RS09950	COG0017	Asparaginyl-tRNA synthetase
RI02_RS09955	COG5353	protein conserved in bacteria
RI02_RS09965	COG1199	ATP-dependent helicase activity
RI02_RS09965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RI02_RS09970	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
RI02_RS09975	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RI02_RS09980	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RI02_RS09990	COG0617	tRNA 3'-terminal CCA addition
RI02_RS09995	COG0438	transferase activity, transferring glycosyl groups
RI02_RS10000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RI02_RS10005	COG1803	Methylglyoxal synthase
RI02_RS10010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RI02_RS10015	COG1694	Mazg nucleotide pyrophosphohydrolase
RI02_RS10020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RI02_RS10030	COG4347	Protein of unknown function (DUF1405)
RI02_RS10035	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RI02_RS10035	COG2010	Cytochrome c
RI02_RS10040	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RI02_RS10045	COG0723	plastoquinol--plastocyanin reductase activity
RI02_RS10055	COG5582	Belongs to the UPF0302 family
RI02_RS10060	COG0457	Tetratricopeptide repeat
RI02_RS10065	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RI02_RS10070	COG0287	Prephenate dehydrogenase
RI02_RS10075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RI02_RS10080	COG0159	tryptophan synthase activity
RI02_RS10085	COG0133	tryptophan synthase activity
RI02_RS10090	COG0135	phosphoribosylanthranilate isomerase activity
RI02_RS10095	COG0134	indole-3-glycerol-phosphate synthase activity
RI02_RS10100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RI02_RS10110	COG4401	Chorismate mutase type I
RI02_RS10115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RI02_RS10120	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RI02_RS10125	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RI02_RS10130	COG0105	UTP biosynthetic process
RI02_RS10135	COG0142	geranyltranstransferase activity
RI02_RS10140	COG2226	methyltransferase
RI02_RS10145	COG0142	geranyltranstransferase activity
RI02_RS10155	COG0302	gtp cyclohydrolase
RI02_RS10160	COG0776	regulation of translation
RI02_RS10165	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
RI02_RS10180	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RI02_RS10185	COG1160	GTP binding
RI02_RS10210	COG1304	FMN binding
RI02_RS10215	COG0539	negative regulation of cytoplasmic translation
RI02_RS10220	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RI02_RS10230	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
RI02_RS10235	COG2959	enzyme of heme biosynthesis
RI02_RS10240	COG3773	Cell wall hydrolase
RI02_RS10240	COG3409	Peptidoglycan-binding domain 1 protein
RI02_RS10245	COG2339	peptidase activity
RI02_RS10250	COG0492	ferredoxin-NADP+ reductase activity
RI02_RS10255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RI02_RS10260	COG4862	establishment of competence for transformation
RI02_RS10265	COG1408	metallophosphoesterase
RI02_RS10275	COG1388	LysM domain
RI02_RS10280	COG1266	CAAX protease self-immunity
RI02_RS10285	COG0514	ATP-dependent DNA helicase (RecQ)
RI02_RS10290	COG4955	Helix-turn-helix domain
RI02_RS10295	COG1141	Ferredoxin
RI02_RS10300	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
RI02_RS10305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RI02_RS10320	COG1595	DNA-templated transcription, initiation
RI02_RS10325	COG5002	protein histidine kinase activity
RI02_RS10330	COG0745	RESPONSE REGULATOR receiver
RI02_RS10335	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RI02_RS10340	COG1333	cytochrome c biogenesis protein
RI02_RS10345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RI02_RS10350	COG1187	pseudouridine synthase activity
RI02_RS10355	COG0700	Nucleoside recognition
RI02_RS10360	COG2715	membrane protein required for spore maturation
RI02_RS10365	COG1686	Belongs to the peptidase S11 family
RI02_RS10375	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RI02_RS10380	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RI02_RS10390	COG1547	Domain of unknown function (DUF309)
RI02_RS10395	COG0456	acetyltransferase
RI02_RS10400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RI02_RS10405	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RI02_RS10405	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RI02_RS10410	COG0307	riboflavin synthase, alpha
RI02_RS10430	COG2814	Major facilitator Superfamily
RI02_RS10435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RI02_RS10440	COG4086	secreted protein
RI02_RS10445	COG0019	diaminopimelate decarboxylase activity
RI02_RS10450	COG0697	spore germination
RI02_RS10465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RI02_RS10485	COG1191	sigma factor activity
RI02_RS10490	COG2172	sigma factor antagonist activity
RI02_RS10500	COG1686	Belongs to the peptidase S11 family
RI02_RS10505	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RI02_RS10510	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RI02_RS10515	COG4974	Belongs to the 'phage' integrase family
RI02_RS10525	COG0735	belongs to the Fur family
RI02_RS10530	COG1300	Membrane
RI02_RS10535	COG1404	Belongs to the peptidase S8 family
RI02_RS10545	COG2153	protein acetylation
RI02_RS10550	COG1379	DNA repair
RI02_RS10555	COG0494	nUDIX hydrolase
RI02_RS10560	COG0667	Aldo Keto reductase
RI02_RS10570	COG1073	alpha beta
RI02_RS10575	COG0457	Tetratricopeptide repeat
RI02_RS10585	COG4918	Iron-sulphur cluster biosynthesis
RI02_RS10590	COG4305	rare lipoprotein A
RI02_RS10595	COG0456	acetyltransferase
RI02_RS10595	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
RI02_RS10600	COG0456	acetyltransferase
RI02_RS10610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RI02_RS10620	COG2211	Major facilitator Superfamily
RI02_RS10625	COG1072	(Pantothenic acid kinase))
RI02_RS10630	COG0446	pyridine nucleotide-disulphide oxidoreductase
RI02_RS10640	COG0300	oxidoreductase activity
RI02_RS10645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RI02_RS10650	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RI02_RS10670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RI02_RS10675	COG4187	Peptidase family M20/M25/M40
RI02_RS10680	COG1902	pentaerythritol trinitrate reductase activity
RI02_RS10685	COG0596	Alpha beta hydrolase
RI02_RS10690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RI02_RS10700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RI02_RS10705	COG2188	Transcriptional regulator
RI02_RS10710	COG2723	6-phospho-beta-galactosidase activity
RI02_RS10715	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RI02_RS10720	COG1447	Phosphotransferase system cellobiose-specific component IIA
RI02_RS10725	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RI02_RS10735	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS10745	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RI02_RS10750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RI02_RS10760	COG0706	membrane insertase activity
RI02_RS10765	COG0835	chemotaxis
RI02_RS10770	COG2195	Cleaves the N-terminal amino acid of tripeptides
RI02_RS10775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RI02_RS10780	COG0346	lactoylglutathione lyase activity
RI02_RS10790	COG1376	ErfK ybiS ycfS ynhG family protein
RI02_RS10795	COG4129	membrane
RI02_RS10800	COG1126	abc transporter atp-binding protein
RI02_RS10805	COG0765	amino acid transport
RI02_RS10810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RI02_RS10820	COG1597	lipid kinase activity
RI02_RS10830	COG0508	dehydrogenase complex catalyzes the overall conversion of
RI02_RS10835	COG0022	dehydrogenase e1 component
RI02_RS10840	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RI02_RS10845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RI02_RS10850	COG3426	butyrate kinase activity
RI02_RS10855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RI02_RS10860	COG0280	phosphate acetyltransferase
RI02_RS10865	COG3829	transcription factor binding
RI02_RS10865	COG3290	protein histidine kinase activity
RI02_RS10875	COG0584	glycerophosphoryl diester phosphodiesterase
RI02_RS10880	COG0457	Tetratricopeptide repeat
RI02_RS10885	COG0745	RESPONSE REGULATOR receiver
RI02_RS10890	COG0750	zinc metalloprotease
RI02_RS10895	COG0497	DNA recombination
RI02_RS10900	COG1438	arginine binding
RI02_RS10905	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
RI02_RS10910	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RI02_RS10915	COG0142	geranyltranstransferase activity
RI02_RS10920	COG1722	exodeoxyribonuclease VII activity
RI02_RS10925	COG1570	exodeoxyribonuclease VII activity
RI02_RS10930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RI02_RS10935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RI02_RS10940	COG1302	Protein conserved in bacteria
RI02_RS10945	COG0439	Biotin carboxylase
RI02_RS10950	COG0511	ligase activity, forming carbon-carbon bonds
RI02_RS10990	COG3854	ATPases associated with a variety of cellular activities
RI02_RS11000	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RI02_RS11005	COG0006	proline dipeptidase activity
RI02_RS11010	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RI02_RS11020	COG3872	metal-dependent enzyme
RI02_RS11030	COG1752	Esterase of the alpha-beta hydrolase superfamily
RI02_RS11035	COG1321	iron dependent repressor
RI02_RS11040	COG0095	Lipoate-protein ligase
RI02_RS11045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RI02_RS11050	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RI02_RS11055	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RI02_RS11060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RI02_RS11065	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RI02_RS11090	COG0681	Belongs to the peptidase S26 family
RI02_RS11125	COG4970	Tfp pilus assembly protein FimT
RI02_RS11130	COG4537	Required for transformation and DNA binding
RI02_RS11135	COG1459	type II secretion system
RI02_RS11140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RI02_RS11145	COG1366	Belongs to the anti-sigma-factor antagonist family
RI02_RS11155	COG1393	Belongs to the ArsC family
RI02_RS11165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RI02_RS11175	COG0011	TIGRFAM Protein of
RI02_RS11180	COG2814	Major facilitator Superfamily
RI02_RS11185	COG2866	Carboxypeptidase
RI02_RS11190	COG1368	sulfuric ester hydrolase activity
RI02_RS11195	COG1940	carbohydrate kinase activity
RI02_RS11200	COG4483	Protein conserved in bacteria
RI02_RS11205	COG0457	Tetratricopeptide repeat
RI02_RS11205	COG0705	Rhomboid family
RI02_RS11220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RI02_RS11225	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RI02_RS11235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RI02_RS11240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RI02_RS11245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RI02_RS11250	COG0581	inorganic phosphate transmembrane transporter activity
RI02_RS11255	COG0573	inorganic phosphate transmembrane transporter activity
RI02_RS11260	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RI02_RS11265	COG0768	penicillin binding
RI02_RS11270	COG0477	Major facilitator Superfamily
RI02_RS11275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RI02_RS11280	COG2839	Protein conserved in bacteria
RI02_RS11285	COG5521	maltodextrose utilization protein MalA
RI02_RS11290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RI02_RS11295	COG1388	LysM domain
RI02_RS11300	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RI02_RS11305	COG4709	membrane
RI02_RS11310	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
RI02_RS11315	COG1940	carbohydrate kinase activity
RI02_RS11320	COG0735	belongs to the Fur family
RI02_RS11325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RI02_RS11330	COG1121	(ABC) transporter
RI02_RS11335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RI02_RS11350	COG0513	Belongs to the DEAD box helicase family
RI02_RS11360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RI02_RS11365	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RI02_RS11370	COG2384	SAM-dependent methyltransferase
RI02_RS11375	COG2010	Cytochrome c
RI02_RS11380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RI02_RS11385	COG0358	DNA primase activity
RI02_RS11390	COG1671	Belongs to the UPF0178 family
RI02_RS11395	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RI02_RS11400	COG0517	IMP dehydrogenase activity
RI02_RS11405	COG0751	glycine-tRNA ligase activity
RI02_RS11410	COG0752	glycyl-tRNA synthetase alpha subunit
RI02_RS11415	COG1381	Involved in DNA repair and RecF pathway recombination
RI02_RS11425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RI02_RS11430	COG0295	cytidine deaminase activity
RI02_RS11435	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RI02_RS11440	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RI02_RS11445	COG1480	7TM receptor with intracellular HD hydrolase
RI02_RS11450	COG1702	phosphate starvation-inducible protein PhoH
RI02_RS11455	COG0561	phosphatase activity
RI02_RS11470	COG4864	UPF0365 protein
RI02_RS11475	COG1030	water channel activity
RI02_RS11480	COG1610	YqeY-like protein
RI02_RS11490	COG1283	sodium-dependent phosphate transmembrane transporter activity
RI02_RS11495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RI02_RS11500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RI02_RS11505	COG2264	protein methyltransferase activity
RI02_RS11510	COG0484	heat shock protein binding
RI02_RS11515	COG0443	Heat shock 70 kDa protein
RI02_RS11520	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RI02_RS11525	COG1420	regulation of RNA biosynthetic process
RI02_RS11530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RI02_RS11535	COG0481	GTPase activity
RI02_RS11545	COG0860	N-Acetylmuramoyl-L-alanine amidase
RI02_RS11550	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RI02_RS11555	COG0268	Binds directly to 16S ribosomal RNA
RI02_RS11560	COG1466	dna polymerase III delta subunit
RI02_RS11570	COG0658	competence protein
RI02_RS11570	COG2333	competence protein COMEC
RI02_RS11575	COG2131	deaminase
RI02_RS11580	COG1596	polysaccharide export
RI02_RS11580	COG1555	photosystem II stabilization
RI02_RS11585	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RI02_RS11590	COG2226	methyltransferase
RI02_RS11595	COG0799	negative regulation of ribosome biogenesis
RI02_RS11600	COG1713	HD superfamily hydrolase involved in NAD metabolism
RI02_RS11605	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RI02_RS11610	COG1534	Rna-binding protein
RI02_RS11615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RI02_RS11620	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RI02_RS11625	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
RI02_RS11640	COG2755	lipolytic protein G-D-S-L family
RI02_RS11650	COG0457	Tetratricopeptide repeat
RI02_RS11680	COG0726	polysaccharide deacetylase
RI02_RS11715	COG1131	(ABC) transporter
RI02_RS11740	COG2160	L-arabinose isomerase activity
RI02_RS11755	COG1609	Transcriptional regulator
RI02_RS11765	COG1846	Transcriptional regulator
RI02_RS11775	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RI02_RS11780	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
RI02_RS11785	COG1733	regulation of RNA biosynthetic process
RI02_RS11790	COG0657	acetylesterase activity
RI02_RS11855	COG2602	Beta-lactamase
RI02_RS11860	COG1960	acyl-CoA dehydrogenase activity
RI02_RS11865	COG1126	abc transporter atp-binding protein
RI02_RS11870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RI02_RS11875	COG0765	amino acid transport
RI02_RS11885	COG3546	catalase activity
RI02_RS11890	COG1063	alcohol dehydrogenase
RI02_RS11900	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS11910	COG1115	amino acid carrier protein
RI02_RS11915	COG0583	DNA-binding transcription factor activity
RI02_RS11920	COG0842	Transport permease protein
RI02_RS11925	COG0842	Transport permease protein
RI02_RS11925	COG1511	domain protein
RI02_RS11930	COG1131	(ABC) transporter
RI02_RS11935	COG1063	alcohol dehydrogenase
RI02_RS11940	COG2226	methyltransferase
RI02_RS11965	COG0626	cystathionine gamma-synthase activity
RI02_RS11970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RI02_RS11975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RI02_RS11980	COG2226	methyltransferase
RI02_RS11995	COG0768	penicillin binding
RI02_RS12000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RI02_RS12005	COG0572	uridine kinase
RI02_RS12010	COG0826	peptidase U32
RI02_RS12015	COG0826	peptidase U32
RI02_RS12020	COG4122	O-methyltransferase activity
RI02_RS12025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RI02_RS12030	COG0183	Belongs to the thiolase family
RI02_RS12035	COG0318	PFAM AMP-dependent synthetase and ligase
RI02_RS12040	COG1268	BioY protein
RI02_RS12045	COG3906	Belongs to the UPF0473 family
RI02_RS12050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RI02_RS12055	COG4472	Bacterial protein of unknown function (DUF965)
RI02_RS12060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RI02_RS12065	COG0628	permease
RI02_RS12070	COG1126	abc transporter atp-binding protein
RI02_RS12075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RI02_RS12080	COG0765	amino acid transport
RI02_RS12085	COG0765	amino acid transport
RI02_RS12100	COG3881	PFAM PRC-barrel domain
RI02_RS12105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RI02_RS12110	COG0457	Tetratricopeptide repeat
RI02_RS12115	COG0482	sulfurtransferase activity
RI02_RS12120	COG1104	cysteine desulfurase activity
RI02_RS12125	COG1959	2 iron, 2 sulfur cluster binding
RI02_RS12130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RI02_RS12135	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RI02_RS12150	COG0124	histidyl-tRNA synthetase
RI02_RS12160	COG4991	sh3 domain protein
RI02_RS12160	COG0860	N-Acetylmuramoyl-L-alanine amidase
RI02_RS12160	COG3103	Sh3 type 3 domain protein
RI02_RS12165	COG1490	D-aminoacyl-tRNA deacylase activity
RI02_RS12170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RI02_RS12175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RI02_RS12180	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RI02_RS12180	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
RI02_RS12185	COG5416	Lipopolysaccharide assembly protein A domain
RI02_RS12190	COG0490	domain, Protein
RI02_RS12195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RI02_RS12195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RI02_RS12205	COG2244	polysaccharide biosynthetic process
RI02_RS12210	COG2323	membrane
RI02_RS12220	COG1862	Preprotein translocase
RI02_RS12225	COG0343	queuine tRNA-ribosyltransferase activity
RI02_RS12230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RI02_RS12240	COG2255	four-way junction helicase activity
RI02_RS12245	COG0632	four-way junction helicase activity
RI02_RS12255	COG2112	serine threonine protein kinase
RI02_RS12270	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RI02_RS12285	COG1388	LysM domain
RI02_RS12290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RI02_RS12295	COG0157	Belongs to the NadC ModD family
RI02_RS12300	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RI02_RS12305	COG1104	cysteine desulfurase activity
RI02_RS12310	COG1827	regulation of RNA biosynthetic process
RI02_RS12315	COG0077	Prephenate dehydratase
RI02_RS12320	COG4492	Belongs to the UPF0735 family
RI02_RS12325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RI02_RS12330	COG3290	protein histidine kinase activity
RI02_RS12335	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RI02_RS12340	COG2868	ribosomal protein
RI02_RS12345	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RI02_RS12350	COG1994	Peptidase M50
RI02_RS12355	COG0739	heme binding
RI02_RS12360	COG2894	cell division
RI02_RS12365	COG0850	regulation of cytokinetic process
RI02_RS12370	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
RI02_RS12380	COG1077	Cell shape determining protein MreB Mrl
RI02_RS12385	COG2003	Belongs to the UPF0758 family
RI02_RS12390	COG0424	maF-like protein
RI02_RS12400	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RI02_RS12405	COG0285	dihydrofolate synthase activity
RI02_RS12410	COG0525	valine-tRNA ligase activity
RI02_RS12420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RI02_RS12425	COG1388	LysM domain
RI02_RS12430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RI02_RS12435	COG0113	porphobilinogen synthase activity
RI02_RS12440	COG1587	Uroporphyrinogen-III synthase
RI02_RS12445	COG0181	hydroxymethylbilane synthase activity
RI02_RS12450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RI02_RS12455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RI02_RS12480	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RI02_RS12485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RI02_RS12490	COG1067	ATP-dependent peptidase activity
RI02_RS12490	COG0470	DNA polymerase III
RI02_RS12495	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RI02_RS12500	COG0544	peptidyl-prolyl cis-trans isomerase activity
RI02_RS12505	COG1477	protein flavinylation
RI02_RS12505	COG0457	Tetratricopeptide repeat
RI02_RS12510	COG0066	3-isopropylmalate dehydratase activity
RI02_RS12515	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RI02_RS12520	COG0473	3-isopropylmalate dehydrogenase activity
RI02_RS12525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RI02_RS12530	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RI02_RS12535	COG0440	acetolactate synthase activity
RI02_RS12540	COG0028	Belongs to the TPP enzyme family
RI02_RS12545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RI02_RS12550	COG2706	6-phosphogluconolactonase activity
RI02_RS12555	COG3339	Conserved Protein
RI02_RS12560	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
RI02_RS12565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RI02_RS12570	COG1696	Membrane protein involved in D-alanine export
RI02_RS12575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RI02_RS12610	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
RI02_RS12615	COG5444	nuclease activity
RI02_RS12630	COG0622	Phosphoesterase
RI02_RS12635	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RI02_RS12640	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RI02_RS12645	COG5401	PFAM Sporulation and spore germination
RI02_RS12650	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RI02_RS12655	COG1846	Transcriptional regulator
RI02_RS12660	COG2197	response regulator
RI02_RS12685	COG3409	Peptidoglycan-binding domain 1 protein
RI02_RS12685	COG5632	N-Acetylmuramoyl-L-alanine amidase
RI02_RS12690	COG4824	toxin secretion phage lysis holin
RI02_RS12720	COG1705	Flagellar rod assembly protein muramidase FlgJ
RI02_RS12795	COG1802	Transcriptional regulator
RI02_RS12795	COG4626	Terminase
RI02_RS12835	COG0582	viral genome integration into host DNA
RI02_RS12840	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RI02_RS12940	COG2197	response regulator
RI02_RS12945	COG2851	Citrate transporter
RI02_RS12950	COG0583	DNA-binding transcription factor activity
RI02_RS12955	COG2828	Protein conserved in bacteria
RI02_RS12965	COG0824	Thioesterase
RI02_RS12970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RI02_RS12975	COG1053	succinate dehydrogenase
RI02_RS12980	COG2009	succinate dehydrogenase
RI02_RS12985	COG1719	4-vinyl reductase, 4VR
RI02_RS12990	COG0527	aspartate kinase activity
RI02_RS12995	COG0322	excinuclease ABC activity
RI02_RS13000	COG3118	belongs to the thioredoxin family
RI02_RS13005	COG3534	alpha-L-arabinofuranosidase
RI02_RS13010	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RI02_RS13015	COG2086	electron transfer activity
RI02_RS13020	COG1024	Enoyl-CoA hydratase
RI02_RS13025	COG1309	transcriptional regulator
RI02_RS13030	COG0318	PFAM AMP-dependent synthetase and ligase
RI02_RS13040	COG3766	membrane
RI02_RS13045	COG1193	negative regulation of DNA recombination
RI02_RS13050	COG1796	DNA polymerase
RI02_RS13050	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RI02_RS13055	COG1286	toxin biosynthetic process
RI02_RS13060	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
RI02_RS13065	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RI02_RS13070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RI02_RS13070	COG0072	phenylalanine-tRNA ligase activity
RI02_RS13075	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RI02_RS13080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RI02_RS13090	COG1966	Carbon starvation protein
RI02_RS13095	COG1363	Peptidase, m42
RI02_RS13105	COG3326	Membrane
RI02_RS13110	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RI02_RS13115	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RI02_RS13120	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RI02_RS13130	COG1011	Hydrolase
RI02_RS13140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RI02_RS13150	COG0398	Pfam SNARE associated Golgi protein
RI02_RS13155	COG1484	DNA-dependent DNA replication
RI02_RS13160	COG3611	Membrane attachment protein
RI02_RS13165	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RI02_RS13175	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
RI02_RS13180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RI02_RS13185	COG0237	dephospho-CoA kinase activity
RI02_RS13190	COG1971	Probably functions as a manganese efflux pump
RI02_RS13195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RI02_RS13200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RI02_RS13200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RI02_RS13205	COG5002	protein histidine kinase activity
RI02_RS13210	COG0745	RESPONSE REGULATOR receiver
RI02_RS13215	COG0039	L-malate dehydrogenase activity
RI02_RS13220	COG0538	isocitrate dehydrogenase activity
RI02_RS13225	COG0372	Belongs to the citrate synthase family
RI02_RS13230	COG2707	UPF0756 membrane protein
RI02_RS13235	COG0628	permease
RI02_RS13240	COG3030	protein affecting phage T7 exclusion by the F plasmid
RI02_RS13250	COG0205	6-phosphofructokinase activity
RI02_RS13255	COG0825	malonyl-CoA metabolic process
RI02_RS13260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RI02_RS13265	COG0281	malic enzyme
RI02_RS13270	COG0587	DNA-directed DNA polymerase activity
RI02_RS13290	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RI02_RS13300	COG4109	DRTGG domain
RI02_RS13305	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RI02_RS13310	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS13320	COG0165	Argininosuccinate lyase
RI02_RS13325	COG0137	argininosuccinate synthase activity
RI02_RS13330	COG0521	Mo-molybdopterin cofactor biosynthetic process
RI02_RS13335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RI02_RS13340	COG0827	DNA restriction-modification system
RI02_RS13345	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RI02_RS13350	COG3874	Sporulation protein YtfJ
RI02_RS13360	COG1714	RDD family
RI02_RS13365	COG0616	signal peptide processing
RI02_RS13370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RI02_RS13380	COG3239	Fatty acid desaturase
RI02_RS13385	COG4585	Histidine kinase
RI02_RS13390	COG2197	response regulator
RI02_RS13395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RI02_RS13400	COG0745	RESPONSE REGULATOR receiver
RI02_RS13405	COG2205	protein histidine kinase activity
RI02_RS13410	COG1136	(ABC) transporter
RI02_RS13415	COG0577	efflux transmembrane transporter activity
RI02_RS13420	COG0402	S-adenosylhomocysteine deaminase activity
RI02_RS13425	COG2249	NAD(P)H dehydrogenase (quinone) activity
RI02_RS13440	COG1279	arginine transmembrane transporter activity
RI02_RS13445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RI02_RS13455	COG0301	tRNA thio-modification
RI02_RS13460	COG1104	cysteine desulfurase activity
RI02_RS13465	COG1114	Component of the transport system for branched-chain amino acids
RI02_RS13470	COG1114	Component of the transport system for branched-chain amino acids
RI02_RS13475	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
RI02_RS13480	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RI02_RS13485	COG1309	transcriptional regulator
RI02_RS13490	COG1956	GAF domain-containing protein
RI02_RS13495	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RI02_RS13505	COG1335	isochorismatase
RI02_RS13515	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
RI02_RS13520	COG2329	Antibiotic biosynthesis monooxygenase
RI02_RS13525	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RI02_RS13530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RI02_RS13535	COG0454	-acetyltransferase
RI02_RS13540	COG0517	IMP dehydrogenase activity
RI02_RS13545	COG0123	including yeast histone deacetylase and acetoin utilization protein
RI02_RS13550	COG1609	Transcriptional regulator
RI02_RS13555	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
RI02_RS13555	COG1605	Chorismate mutase
RI02_RS13560	COG3118	belongs to the thioredoxin family
RI02_RS13565	COG4980	gas vesicle protein
RI02_RS13570	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
RI02_RS13575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RI02_RS13580	COG1674	ftsk spoiiie
RI02_RS13585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RI02_RS13590	COG4848	Belongs to the UPF0354 family
RI02_RS13595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RI02_RS13610	COG1363	Peptidase, m42
RI02_RS13615	COG5584	Small secreted protein
RI02_RS13620	COG0281	malic enzyme
RI02_RS13625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RI02_RS13630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RI02_RS13640	COG0510	thiamine kinase activity
RI02_RS13645	COG1597	lipid kinase activity
RI02_RS13655	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
RI02_RS13660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RI02_RS13665	COG3340	Belongs to the peptidase S51 family
RI02_RS13670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RI02_RS13675	COG2252	PERMEase
RI02_RS13680	COG1349	DNA-binding transcription factor activity
RI02_RS13685	COG1187	pseudouridine synthase activity
RI02_RS13690	COG2244	polysaccharide biosynthetic process
RI02_RS13695	COG2081	HI0933 family
RI02_RS13705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RI02_RS13710	COG3196	Protein conserved in bacteria
RI02_RS13720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RI02_RS13725	COG5578	integral membrane protein
RI02_RS13730	COG0673	inositol 2-dehydrogenase activity
RI02_RS13735	COG1653	transport
RI02_RS13740	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
RI02_RS13745	COG4209	transmembrane transport
RI02_RS13750	COG2207	Transcriptional regulator
RI02_RS13755	COG1733	regulation of RNA biosynthetic process
RI02_RS13760	COG2814	Major facilitator Superfamily
RI02_RS13765	COG0656	L-ascorbic acid biosynthetic process
RI02_RS13770	COG1653	transport
RI02_RS13775	COG0395	ABC-type sugar transport system, permease component
RI02_RS13780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RI02_RS13785	COG1073	alpha beta
RI02_RS13790	COG0495	leucyl-tRNA aminoacylation
RI02_RS13800	COG1366	Belongs to the anti-sigma-factor antagonist family
RI02_RS13800	COG2202	Pas domain
RI02_RS13805	COG2433	Pfam Transposase IS66
RI02_RS13810	COG0577	efflux transmembrane transporter activity
RI02_RS13815	COG1136	(ABC) transporter
RI02_RS13825	COG1131	(ABC) transporter
RI02_RS13830	COG1725	Transcriptional regulator
RI02_RS13850	COG1242	4 iron, 4 sulfur cluster binding
RI02_RS13855	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
RI02_RS13860	COG4326	sporulation control protein
RI02_RS13870	COG2267	carboxylic ester hydrolase activity
RI02_RS13875	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RI02_RS13880	COG0367	asparagine synthase
RI02_RS13885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RI02_RS13890	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
RI02_RS13900	COG1506	peptidase
RI02_RS13905	COG1233	COG1233 Phytoene dehydrogenase and related
RI02_RS13925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RI02_RS13930	COG1116	anion transmembrane transporter activity
RI02_RS13935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RI02_RS13940	COG0494	nUDIX hydrolase
RI02_RS13945	COG2310	stress, protein
RI02_RS13960	COG4824	toxin secretion phage lysis holin
RI02_RS13970	COG0783	Belongs to the Dps family
RI02_RS13985	COG1854	S-ribosylhomocysteine lyase activity
RI02_RS13990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RI02_RS13995	COG0288	reversible hydration of carbon dioxide
RI02_RS14000	COG0803	Belongs to the bacterial solute-binding protein 9 family
RI02_RS14000	COG3443	Belongs to the bacterial solute-binding protein 9 family
RI02_RS14010	COG1271	oxidase subunit
RI02_RS14015	COG1294	oxidase, subunit
RI02_RS14030	COG4948	Mandelate Racemase Muconate Lactonizing
RI02_RS14035	COG0318	PFAM AMP-dependent synthetase and ligase
RI02_RS14040	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RI02_RS14045	COG0596	Alpha beta hydrolase
RI02_RS14050	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
RI02_RS14055	COG1169	isochorismate synthase
RI02_RS14060	COG1575	Belongs to the MenA family. Type 1 subfamily
RI02_RS14065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RI02_RS14195	COG3859	Proton-coupled thiamine transporter YuaJ
RI02_RS14200	COG1247	-acetyltransferase
RI02_RS14205	COG3339	Conserved Protein
RI02_RS14210	COG0772	Belongs to the SEDS family
RI02_RS14215	COG0772	Belongs to the SEDS family
RI02_RS14220	COG2268	Band 7 protein
RI02_RS14225	COG1585	Membrane protein implicated in regulation of membrane protease activity
RI02_RS14230	COG2318	DinB family
RI02_RS14235	COG1454	alcohol dehydrogenase
RI02_RS14240	COG1012	belongs to the aldehyde dehydrogenase family
RI02_RS14245	COG1510	regulation of RNA biosynthetic process
RI02_RS14260	COG5632	N-Acetylmuramoyl-L-alanine amidase
RI02_RS14260	COG3409	Peptidoglycan-binding domain 1 protein
RI02_RS14315	COG3778	Protein conserved in bacteria
RI02_RS14320	COG3299	homolog of phage Mu protein gp47
RI02_RS14325	COG3628	GPW Gp25 family protein
RI02_RS14335	COG4193	domain, Protein
RI02_RS14340	COG1652	LysM domain
RI02_RS14345	COG5280	Phage tail tape measure protein TP901
RI02_RS14345	COG3953	SLT domain
RI02_RS14345	COG3953	SLT domain
RI02_RS14345	COG5280	Phage tail tape measure protein TP901
RI02_RS14400	COG4653	Phage capsid family
RI02_RS14405	COG0338	D12 class N6 adenine-specific DNA methyltransferase
RI02_RS14410	COG5518	Phage portal protein
RI02_RS14415	COG1783	phage Terminase large subunit
RI02_RS14420	COG5484	DNA packaging
RI02_RS14425	COG1595	DNA-templated transcription, initiation
RI02_RS14435	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
RI02_RS14455	COG1396	sequence-specific DNA binding
RI02_RS14465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RI02_RS14480	COG0628	permease
RI02_RS14490	COG0673	inositol 2-dehydrogenase activity
RI02_RS14495	COG0693	protein deglycase activity
RI02_RS14500	COG0840	transmembrane signaling receptor activity
RI02_RS14505	COG0840	transmembrane signaling receptor activity
RI02_RS14510	COG0840	transmembrane signaling receptor activity
RI02_RS14515	COG0840	transmembrane signaling receptor activity
RI02_RS14530	COG2070	2-Nitropropane dioxygenase
RI02_RS14535	COG0432	Pfam Uncharacterised protein family UPF0047
RI02_RS14540	COG1253	flavin adenine dinucleotide binding
RI02_RS14545	COG2738	Putative neutral zinc metallopeptidase
RI02_RS14555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RI02_RS14570	COG0166	Belongs to the GPI family
RI02_RS14575	COG1979	alcohol dehydrogenase
RI02_RS14580	COG1979	alcohol dehydrogenase
RI02_RS14585	COG2155	Conserved Protein
RI02_RS14590	COG1098	S1 RNA binding domain
RI02_RS14595	COG0436	Aminotransferase
RI02_RS14600	COG1522	sequence-specific DNA binding
RI02_RS14605	COG2267	carboxylic ester hydrolase activity
RI02_RS14615	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RI02_RS14620	COG2205	protein histidine kinase activity
RI02_RS14635	COG5018	Exonuclease
RI02_RS14640	COG2814	Major facilitator Superfamily
RI02_RS14645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RI02_RS14650	COG3011	Protein conserved in bacteria
RI02_RS14660	COG3290	protein histidine kinase activity
RI02_RS14665	COG4565	transcriptional regulatory protein
RI02_RS14670	COG1744	ABC transporter substrate-binding protein PnrA-like
RI02_RS14675	COG3845	ABC transporter
RI02_RS14680	COG4603	Belongs to the binding-protein-dependent transport system permease family
RI02_RS14685	COG1079	Belongs to the binding-protein-dependent transport system permease family
RI02_RS14690	COG3493	citrate carrier protein
RI02_RS14700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RI02_RS14700	COG2111	Na H antiporter
RI02_RS14705	COG2111	Na H antiporter
RI02_RS14710	COG1006	Multisubunit Na H antiporter MnhC subunit
RI02_RS14715	COG0651	ATP synthesis coupled electron transport
RI02_RS14720	COG1863	multisubunit Na H antiporter MnhE subunit
RI02_RS14725	COG2212	antiporter activity
RI02_RS14730	COG1320	monovalent cation:proton antiporter activity
RI02_RS14735	COG2050	protein possibly involved in aromatic compounds catabolism
RI02_RS14740	COG2197	response regulator
RI02_RS14745	COG4585	Histidine kinase
RI02_RS14755	COG0142	geranyltranstransferase activity
RI02_RS14770	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
RI02_RS14775	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RI02_RS14780	COG1335	isochorismatase
RI02_RS14785	COG5506	Protein of unknown function (DUF1694)
RI02_RS14805	COG0628	permease
RI02_RS14820	COG1418	mRNA catabolic process
RI02_RS14825	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS14835	COG1511	domain protein
RI02_RS14840	COG1674	ftsk spoiiie
RI02_RS14840	COG0433	COG0433 Predicted ATPase
RI02_RS14845	COG4499	WXG100 protein secretion system (Wss), protein YukC
RI02_RS14850	COG5417	Belongs to the EsaB family
RI02_RS14855	COG4842	Belongs to the WXG100 family
RI02_RS14860	COG2508	Transcriptional regulator
RI02_RS14860	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
RI02_RS14865	COG0686	Belongs to the AlaDH PNT family
RI02_RS14870	COG1268	BioY protein
RI02_RS14875	COG2056	Na+-H+ antiporter family
RI02_RS14880	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RI02_RS14885	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
RI02_RS14890	COG3584	3D domain protein
RI02_RS14905	COG1252	NADH dehydrogenase
RI02_RS14910	COG0492	ferredoxin-NADP+ reductase activity
RI02_RS14925	COG0789	Transcriptional regulator
RI02_RS14930	COG5504	Zn-dependent protease
RI02_RS14935	COG0316	Belongs to the HesB IscA family
RI02_RS14940	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RI02_RS14945	COG4844	belongs to the
RI02_RS14950	COG1252	NADH dehydrogenase
RI02_RS14960	COG4837	Protein of unknown function (DUF1462)
RI02_RS14965	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
RI02_RS14970	COG1506	peptidase
RI02_RS14970	COG0823	Involved in the tonB-independent uptake of proteins
RI02_RS14970	COG4946	Tricorn protease homolog
RI02_RS14975	COG0083	homoserine kinase activity
RI02_RS14980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RI02_RS14985	COG0460	homoserine dehydrogenase
RI02_RS14990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RI02_RS14995	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RI02_RS15000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RI02_RS15020	COG0647	UMP catabolic process
RI02_RS15025	COG2445	Protein of unknown function DUF86
RI02_RS15030	COG4470	Protein conserved in bacteria
RI02_RS15040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RI02_RS15045	COG0739	heme binding
RI02_RS15065	COG3377	Domain of unknown function (DUF1805)
RI02_RS15070	COG0737	Belongs to the 5'-nucleotidase family
RI02_RS15075	COG1801	Protein of unknown function DUF72
RI02_RS15080	COG2508	Transcriptional regulator
RI02_RS15085	COG2140	Oxalate decarboxylase
RI02_RS15090	COG2814	Major facilitator Superfamily
RI02_RS15095	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RI02_RS15100	COG2356	endonuclease I
RI02_RS15110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RI02_RS15115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RI02_RS15120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RI02_RS15140	COG5002	protein histidine kinase activity
RI02_RS15140	COG0642	Histidine kinase
RI02_RS15145	COG0745	RESPONSE REGULATOR receiver
RI02_RS15150	COG2311	Membrane
RI02_RS15160	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RI02_RS15170	COG1309	transcriptional regulator
RI02_RS15180	COG0719	Fe-S assembly protein
RI02_RS15185	COG0822	iron-sulfur transferase activity
RI02_RS15190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RI02_RS15195	COG0719	Fe-S assembly protein
RI02_RS15200	COG0396	ATPase activity
RI02_RS15210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RI02_RS15215	COG1464	Belongs to the NlpA lipoprotein family
RI02_RS15220	COG2011	ABC-type metal ion transport system permease component
RI02_RS15225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RI02_RS15235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RI02_RS15240	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
RI02_RS15250	COG0509	glycine decarboxylation via glycine cleavage system
RI02_RS15255	COG1393	Belongs to the ArsC family
RI02_RS15260	COG1960	acyl-CoA dehydrogenase activity
RI02_RS15265	COG0183	Belongs to the thiolase family
RI02_RS15270	COG1024	Enoyl-CoA hydratase
RI02_RS15270	COG1250	3-hydroxyacyl-CoA dehydrogenase
RI02_RS15285	COG5577	PFAM Coat F domain
RI02_RS15295	COG1120	ATPase activity
RI02_RS15305	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS15310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RI02_RS15315	COG0745	RESPONSE REGULATOR receiver
RI02_RS15320	COG2205	protein histidine kinase activity
RI02_RS15320	COG2770	Histidine kinase
RI02_RS15330	COG1309	transcriptional regulator
RI02_RS15335	COG0114	fumarate hydratase activity
RI02_RS15345	COG0697	spore germination
RI02_RS15350	COG0814	amino acid
RI02_RS15365	COG2197	response regulator
RI02_RS15370	COG4585	Histidine kinase
RI02_RS15375	COG4758	membrane
RI02_RS15385	COG1842	Phage shock protein A
RI02_RS15390	COG4758	membrane
RI02_RS15395	COG2096	Adenosyltransferase
RI02_RS15400	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS15405	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RI02_RS15430	COG1454	alcohol dehydrogenase
RI02_RS15435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RI02_RS15440	COG1120	ATPase activity
RI02_RS15445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RI02_RS15450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RI02_RS15460	COG2721	sulfolactate sulfo-lyase activity
RI02_RS15465	COG0246	Mannitol dehydrogenase
RI02_RS15470	COG1609	Transcriptional regulator
RI02_RS15475	COG1904	glucuronate isomerase
RI02_RS15480	COG2205	protein histidine kinase activity
RI02_RS15485	COG0745	RESPONSE REGULATOR receiver
RI02_RS15490	COG1120	ATPase activity
RI02_RS15495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RI02_RS15500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RI02_RS15505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RI02_RS15510	COG0531	amino acid
RI02_RS15525	COG1988	membrane-bound metal-dependent
RI02_RS15530	COG1368	sulfuric ester hydrolase activity
RI02_RS15535	COG0725	ABC transporter, periplasmic molybdate-binding protein
RI02_RS15540	COG4149	molybdate abc transporter
RI02_RS15545	COG0656	L-ascorbic acid biosynthetic process
RI02_RS15550	COG1940	carbohydrate kinase activity
RI02_RS15555	COG0025	NhaP-type Na H and K H
RI02_RS15560	COG2860	membrane
RI02_RS15565	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RI02_RS15570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RI02_RS15575	COG2217	Heavy metal translocating P-type atpase
RI02_RS15580	COG1121	(ABC) transporter
RI02_RS15585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RI02_RS15590	COG0803	Belongs to the bacterial solute-binding protein 9 family
RI02_RS15600	COG3226	Transcriptional regulator
RI02_RS15605	COG0784	Response regulator, receiver
RI02_RS15610	COG4191	Histidine kinase
RI02_RS15615	COG1027	Aspartate ammonia-lyase
RI02_RS15630	COG2217	Heavy metal translocating P-type atpase
RI02_RS15635	COG2608	mercury ion transmembrane transporter activity
RI02_RS15640	COG1937	Protein conserved in bacteria
RI02_RS15675	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RI02_RS15680	COG0557	exoribonuclease II activity
RI02_RS15685	COG1647	Serine aminopeptidase, S33
RI02_RS15690	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RI02_RS15695	COG2002	toxin-antitoxin pair type II binding
RI02_RS15700	COG1476	TRANSCRIPTIONal
RI02_RS15705	COG1396	sequence-specific DNA binding
RI02_RS15710	COG1396	sequence-specific DNA binding
RI02_RS15715	COG1733	regulation of RNA biosynthetic process
RI02_RS15720	COG1174	glycine betaine transport
RI02_RS15725	COG1732	Glycine betaine
RI02_RS15730	COG1174	glycine betaine transport
RI02_RS15735	COG1125	glycine betaine transport
RI02_RS15735	COG0517	IMP dehydrogenase activity
RI02_RS15740	COG1510	regulation of RNA biosynthetic process
RI02_RS15745	COG2095	MarC family integral membrane protein
RI02_RS15755	COG0456	acetyltransferase
RI02_RS15775	COG1131	(ABC) transporter
RI02_RS15785	COG0148	phosphopyruvate hydratase activity
RI02_RS15790	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
RI02_RS15795	COG0149	triose-phosphate isomerase activity
RI02_RS15800	COG0126	phosphoglycerate kinase activity
RI02_RS15805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RI02_RS15810	COG2390	Transcriptional regulator
RI02_RS15815	COG0833	amino acid
RI02_RS15820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RI02_RS15825	COG3829	transcription factor binding
RI02_RS15830	COG2186	Transcriptional regulator
RI02_RS15835	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RI02_RS15845	COG0534	Mate efflux family protein
RI02_RS15850	COG4608	Belongs to the ABC transporter superfamily
RI02_RS15855	COG0444	Belongs to the ABC transporter superfamily
RI02_RS15860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RI02_RS15865	COG0601	transmembrane transport
RI02_RS15870	COG0747	negative chemotaxis
RI02_RS15875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RI02_RS15880	COG0110	maltose O-acetyltransferase activity
RI02_RS15885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RI02_RS15890	COG2244	polysaccharide biosynthetic process
RI02_RS15895	COG5039	Polysaccharide pyruvyl transferase
RI02_RS15900	COG1216	Glycosyl transferase, family 2
RI02_RS15910	COG0438	transferase activity, transferring glycosyl groups
RI02_RS15915	COG1215	transferase activity, transferring glycosyl groups
RI02_RS15920	COG0438	transferase activity, transferring glycosyl groups
RI02_RS15925	COG1086	Polysaccharide biosynthesis protein
RI02_RS15930	COG0489	protein tyrosine kinase activity
RI02_RS15935	COG3944	biosynthesis protein
RI02_RS15940	COG1396	sequence-specific DNA binding
RI02_RS15950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RI02_RS15955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RI02_RS15960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RI02_RS15965	COG0726	polysaccharide deacetylase
RI02_RS15970	COG0488	(ABC) transporter
RI02_RS15975	COG4608	Belongs to the ABC transporter superfamily
RI02_RS15990	COG0601	transmembrane transport
RI02_RS15995	COG0747	negative chemotaxis
RI02_RS16000	COG1819	glycosyl
RI02_RS16015	COG0740	serine-type endopeptidase activity
RI02_RS16020	COG1611	Belongs to the LOG family
RI02_RS16025	COG1694	Mazg nucleotide pyrophosphohydrolase
RI02_RS16030	COG0659	secondary active sulfate transmembrane transporter activity
RI02_RS16035	COG0288	reversible hydration of carbon dioxide
RI02_RS16040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RI02_RS16055	COG2162	N-hydroxyarylamine O-acetyltransferase activity
RI02_RS16060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RI02_RS16065	COG1481	regulation of sporulation
RI02_RS16070	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RI02_RS16075	COG1660	Displays ATPase and GTPase activities
RI02_RS16080	COG1051	belongs to the nudix hydrolase family
RI02_RS16085	COG0492	ferredoxin-NADP+ reductase activity
RI02_RS16090	COG0791	NLP P60 protein
RI02_RS16090	COG3883	PFAM NLP P60 protein
RI02_RS16095	COG0457	Tetratricopeptide repeat
RI02_RS16100	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RI02_RS16100	COG0140	phosphoribosyl-ATP diphosphatase activity
RI02_RS16105	COG0107	imidazoleglycerol-phosphate synthase activity
RI02_RS16110	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RI02_RS16115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RI02_RS16120	COG0131	Imidazoleglycerol-phosphate dehydratase
RI02_RS16125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RI02_RS16130	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RI02_RS16135	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RI02_RS16140	COG4990	cell redox homeostasis
RI02_RS16150	COG2910	NAD(P)H-binding
RI02_RS16155	COG1959	2 iron, 2 sulfur cluster binding
RI02_RS16160	COG0110	maltose O-acetyltransferase activity
RI02_RS16165	COG0546	phosphoglycolate phosphatase activity
RI02_RS16170	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
RI02_RS16180	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RI02_RS16185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RI02_RS16190	COG0363	glucosamine-6-phosphate deaminase activity
RI02_RS16195	COG2188	Transcriptional regulator
RI02_RS16200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RI02_RS16205	COG1950	PFAM Membrane protein of
RI02_RS16210	COG1983	PspC domain protein
RI02_RS16215	COG3595	metallopeptidase activity
RI02_RS16230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RI02_RS16240	COG4897	Protein conserved in bacteria
RI02_RS16245	COG0574	Belongs to the PEP-utilizing enzyme family
RI02_RS16245	COG3848	Pyruvate phosphate dikinase
RI02_RS16250	COG1309	transcriptional regulator
RI02_RS16255	COG2814	Major facilitator Superfamily
RI02_RS16265	COG0745	RESPONSE REGULATOR receiver
RI02_RS16270	COG5002	protein histidine kinase activity
RI02_RS16275	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RI02_RS16280	COG0463	Glycosyl transferase, family 2
RI02_RS16285	COG1113	amino acid transport
RI02_RS16290	COG0778	Nitroreductase
RI02_RS16295	COG1733	regulation of RNA biosynthetic process
RI02_RS16300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RI02_RS16310	COG3409	Peptidoglycan-binding domain 1 protein
RI02_RS16310	COG0793	Belongs to the peptidase S41A family
RI02_RS16315	COG0730	response to heat
RI02_RS16320	COG0791	NLP P60 protein
RI02_RS16320	COG3883	PFAM NLP P60 protein
RI02_RS16325	COG2177	Part of the ABC transporter FtsEX involved in
RI02_RS16330	COG2884	Cell division ATP-binding protein ftsE
RI02_RS16335	COG2010	Cytochrome c
RI02_RS16340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RI02_RS16360	COG0653	protein targeting
RI02_RS16365	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RI02_RS16370	COG0840	transmembrane signaling receptor activity
RI02_RS16385	COG1516	flagellar protein fliS
RI02_RS16390	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RI02_RS16395	COG1334	flagellar protein FlaG
RI02_RS16400	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
RI02_RS16405	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
RI02_RS16415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RI02_RS16420	COG4786	Flagellar basal body rod
RI02_RS16420	COG1256	bacterial-type flagellum assembly
RI02_RS16425	COG3418	PFAM FlgN family protein
RI02_RS16440	COG1040	competence protein
RI02_RS16450	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
RI02_RS16455	COG1307	EDD domain protein, DegV family
RI02_RS16460	COG2197	response regulator
RI02_RS16465	COG4585	Histidine kinase
RI02_RS16470	COG1739	Uncharacterized protein family UPF0029
RI02_RS16475	COG1316	TRANSCRIPTIONal
RI02_RS16480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RI02_RS16485	COG0438	transferase activity, transferring glycosyl groups
RI02_RS16490	COG1215	transferase activity, transferring glycosyl groups
RI02_RS16495	COG3206	protein involved in exopolysaccharide biosynthesis
RI02_RS16500	COG3307	-O-antigen
RI02_RS16505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RI02_RS16510	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RI02_RS16515	COG0297	glycogen (starch) synthase activity
RI02_RS16515	COG0438	transferase activity, transferring glycosyl groups
RI02_RS16520	COG2244	polysaccharide biosynthetic process
RI02_RS16535	COG0860	N-Acetylmuramoyl-L-alanine amidase
RI02_RS16535	COG2247	cell wall binding repeat
RI02_RS16540	COG2247	cell wall binding repeat
RI02_RS16540	COG0860	N-Acetylmuramoyl-L-alanine amidase
RI02_RS16545	COG2247	cell wall binding repeat
RI02_RS16545	COG2385	sporulation resulting in formation of a cellular spore
RI02_RS16555	COG1316	TRANSCRIPTIONal
RI02_RS16560	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RI02_RS16565	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RI02_RS16570	COG1134	teichoic acid transport
RI02_RS16575	COG1682	transport, permease protein
RI02_RS16580	COG0463	Glycosyl transferase, family 2
RI02_RS16580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RI02_RS16585	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RI02_RS16595	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RI02_RS16600	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
RI02_RS16605	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RI02_RS16610	COG4193	domain, Protein
RI02_RS16615	COG1482	cell wall glycoprotein biosynthetic process
RI02_RS16625	COG1175	transmembrane transport
RI02_RS16630	COG1653	transport
RI02_RS16635	COG2197	response regulator
RI02_RS16640	COG2972	Histidine kinase
RI02_RS16650	COG0454	-acetyltransferase
RI02_RS16655	COG0800	Aldolase
RI02_RS16660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RI02_RS16665	COG1609	Transcriptional regulator
RI02_RS16670	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
RI02_RS16675	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS16680	COG0697	spore germination
RI02_RS16685	COG0814	amino acid
RI02_RS16700	COG2814	Major facilitator Superfamily
RI02_RS16705	COG1316	TRANSCRIPTIONal
RI02_RS16710	COG0561	phosphatase activity
RI02_RS16715	COG0791	NLP P60 protein
RI02_RS16725	COG2843	Capsule synthesis protein
RI02_RS16735	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RI02_RS16740	COG0697	spore germination
RI02_RS16755	COG1609	Transcriptional regulator
RI02_RS16760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RI02_RS16765	COG1869	D-ribose catabolic process
RI02_RS16770	COG1129	ABC transporter
RI02_RS16775	COG1172	Belongs to the binding-protein-dependent transport system permease family
RI02_RS16780	COG1879	ABC-type sugar transport system periplasmic component
RI02_RS16785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RI02_RS16790	COG0583	DNA-binding transcription factor activity
RI02_RS16795	COG0028	Belongs to the TPP enzyme family
RI02_RS16800	COG3527	Alpha-acetolactate decarboxylase
RI02_RS16805	COG1522	sequence-specific DNA binding
RI02_RS16810	COG2059	Chromate
RI02_RS16815	COG2059	Chromate
RI02_RS16820	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RI02_RS16830	COG4715	Zinc finger, swim domain protein
RI02_RS16835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RI02_RS16840	COG1366	Belongs to the anti-sigma-factor antagonist family
RI02_RS16840	COG2202	Pas domain
RI02_RS16845	COG0561	phosphatase activity
RI02_RS16860	COG1970	mechanosensitive ion channel activity
RI02_RS16865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RI02_RS16870	COG0457	Tetratricopeptide repeat
RI02_RS16875	COG4786	Flagellar basal body rod
RI02_RS16880	COG4786	Flagellar basal body rod
RI02_RS16885	COG1077	Cell shape determining protein MreB Mrl
RI02_RS16890	COG1609	Transcriptional regulator
RI02_RS16895	COG1846	Transcriptional regulator
RI02_RS16900	COG2814	Major facilitator Superfamily
RI02_RS16905	COG0671	phosphoesterase, PA-phosphatase related
RI02_RS16910	COG0477	Major facilitator Superfamily
RI02_RS16915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RI02_RS16920	COG0765	amino acid transport
RI02_RS16925	COG1126	abc transporter atp-binding protein
RI02_RS16930	COG0004	ammonium transporteR
RI02_RS16935	COG0347	Belongs to the P(II) protein family
RI02_RS16940	COG0739	heme binding
RI02_RS16945	COG1247	-acetyltransferase
RI02_RS16980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RI02_RS16985	COG0523	cobalamin synthesis protein
RI02_RS16990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RI02_RS16995	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RI02_RS17000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RI02_RS17005	COG2223	nitrite transmembrane transporter activity
RI02_RS17015	COG2304	oxidoreductase activity
RI02_RS17020	COG2304	oxidoreductase activity
RI02_RS17025	COG2385	sporulation resulting in formation of a cellular spore
RI02_RS17030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RI02_RS17040	COG4836	Membrane
RI02_RS17050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RI02_RS17055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RI02_RS17060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RI02_RS17065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RI02_RS17070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RI02_RS17075	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RI02_RS17080	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RI02_RS17085	COG0356	it plays a direct role in the translocation of protons across the membrane
RI02_RS17095	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RI02_RS17100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RI02_RS17105	COG4475	Protein of unknown function (DUF436)
RI02_RS17110	COG0698	ribose 5-phosphate isomerase
RI02_RS17115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RI02_RS17120	COG1971	Probably functions as a manganese efflux pump
RI02_RS17125	COG0009	L-threonylcarbamoyladenylate synthase
RI02_RS17130	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RI02_RS17145	COG2890	protein-(glutamine-N5) methyltransferase activity
RI02_RS17150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RI02_RS17155	COG0789	Transcriptional regulator
RI02_RS17160	COG0679	Auxin Efflux Carrier
RI02_RS17165	COG0281	malic enzyme
RI02_RS17170	COG1435	thymidine kinase activity
RI02_RS17175	COG0254	rRNA binding
RI02_RS17180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RI02_RS17185	COG1494	fructose-1,6-bisphosphatase
RI02_RS17190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RI02_RS17195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RI02_RS17200	COG0191	fructose-bisphosphate aldolase activity
RI02_RS17205	COG2204	response regulator
RI02_RS17210	COG4821	SIS domain
RI02_RS17215	COG0504	CTP synthase activity
RI02_RS17220	COG3343	RNA polymerase activity
RI02_RS17235	COG1960	acyl-CoA dehydrogenase activity
RI02_RS17240	COG1960	acyl-CoA dehydrogenase activity
RI02_RS17245	COG1250	3-hydroxyacyl-CoA dehydrogenase
RI02_RS17250	COG0183	Belongs to the thiolase family
RI02_RS17255	COG0247	lactate metabolic process
RI02_RS17255	COG2181	nitrate reductase activity
RI02_RS17260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RI02_RS17265	COG4294	response to UV
RI02_RS17275	COG1619	proteins homologs of microcin C7 resistance protein MccF
RI02_RS17285	COG1132	(ABC) transporter
RI02_RS17290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RI02_RS17295	COG1619	proteins homologs of microcin C7 resistance protein MccF
RI02_RS17300	COG0018	arginyl-trna synthetase
RI02_RS17305	COG4506	Protein conserved in bacteria
RI02_RS17315	COG0010	Belongs to the arginase family
RI02_RS17320	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
RI02_RS17325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RI02_RS17335	COG1994	Peptidase M50
RI02_RS17340	COG1942	4-Oxalocrotonate Tautomerase
RI02_RS17350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RI02_RS17355	COG0583	DNA-binding transcription factor activity
RI02_RS17360	COG0431	NADPH-dependent FMN reductase
RI02_RS17365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RI02_RS17370	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RI02_RS17375	COG0454	-acetyltransferase
RI02_RS17380	COG0765	amino acid transport
RI02_RS17390	COG0765	amino acid transport
RI02_RS17395	COG1126	abc transporter atp-binding protein
RI02_RS17400	COG3465	dGTPase activity
RI02_RS17405	COG1078	dGTPase activity
RI02_RS17410	COG4844	belongs to the
RI02_RS17460	COG5444	nuclease activity
RI02_RS17490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RI02_RS17500	COG0280	phosphate acetyltransferase
RI02_RS17510	COG2814	Major facilitator Superfamily
RI02_RS17515	COG1522	sequence-specific DNA binding
RI02_RS17520	COG2814	Major facilitator Superfamily
RI02_RS17525	COG0077	Prephenate dehydratase
RI02_RS17530	COG1917	Cupin 2, conserved barrel domain protein
RI02_RS17535	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS17540	COG0151	Belongs to the GarS family
RI02_RS17545	COG0436	Aminotransferase
RI02_RS17550	COG1028	Short-chain dehydrogenase reductase Sdr
RI02_RS17555	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
RI02_RS17560	COG1091	dTDP-4-dehydrorhamnose reductase activity
RI02_RS17565	COG1088	dTDP-glucose 4,6-dehydratase activity
RI02_RS17570	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RI02_RS17575	COG3980	spore coat polysaccharide biosynthesis protein
RI02_RS17580	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
RI02_RS17585	COG2089	acid synthase
RI02_RS17590	COG0456	acetyltransferase
RI02_RS17595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RI02_RS17600	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RI02_RS17605	COG0463	Glycosyl transferase, family 2
RI02_RS17625	COG2363	Small membrane protein
RI02_RS17630	COG2233	PERMEase
RI02_RS17640	COG1012	belongs to the aldehyde dehydrogenase family
RI02_RS17645	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RI02_RS17650	COG1216	Glycosyl transferase, family 2
RI02_RS17660	COG0351	phosphomethylpyrimidine kinase
RI02_RS17675	COG1621	beta-fructofuranosidase activity
RI02_RS17680	COG1263	PTS System
RI02_RS17680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RI02_RS17685	COG3711	transcriptional antiterminator
RI02_RS17695	COG1404	Belongs to the peptidase S8 family
RI02_RS17705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RI02_RS17710	COG0778	Nitroreductase
RI02_RS17715	COG0772	Belongs to the SEDS family
RI02_RS17725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RI02_RS17730	COG1845	cytochrome c oxidase, subunit III
RI02_RS17735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RI02_RS17740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RI02_RS17750	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
RI02_RS17755	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RI02_RS17760	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RI02_RS17775	COG2246	polysaccharide biosynthetic process
RI02_RS17800	COG0457	Tetratricopeptide repeat
RI02_RS17815	COG3162	membrane
RI02_RS17820	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RI02_RS17835	COG0352	thiamine-phosphate diphosphorylase activity
RI02_RS17840	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
RI02_RS17845	COG0583	DNA-binding transcription factor activity
RI02_RS17850	COG1380	Effector of murein hydrolase LrgA
RI02_RS17855	COG1346	cytolysis
RI02_RS17860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RI02_RS17865	COG0346	lactoylglutathione lyase activity
RI02_RS17875	COG0765	amino acid transport
RI02_RS17880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RI02_RS17885	COG0457	Tetratricopeptide repeat
RI02_RS17895	COG2357	RelA SpoT domain protein
RI02_RS17900	COG1172	Belongs to the binding-protein-dependent transport system permease family
RI02_RS17905	COG1129	ABC transporter
RI02_RS17915	COG3420	alginic acid biosynthetic process
RI02_RS17920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RI02_RS17930	COG1486	melibiose metabolic process
RI02_RS17935	COG1447	Phosphotransferase system cellobiose-specific component IIA
RI02_RS17940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RI02_RS17945	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RI02_RS17950	COG3711	transcriptional antiterminator
RI02_RS17950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RI02_RS17965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RI02_RS17980	COG1595	DNA-templated transcription, initiation
RI02_RS17990	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RI02_RS17995	COG4988	ABC transporter
RI02_RS18000	COG1294	oxidase, subunit
RI02_RS18005	COG1271	oxidase subunit
RI02_RS18010	COG1120	ATPase activity
RI02_RS18015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RI02_RS18020	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RI02_RS18025	COG4509	Sortase family
RI02_RS18050	COG5386	Cell surface protein
RI02_RS18055	COG5386	Cell surface protein
RI02_RS18060	COG1733	regulation of RNA biosynthetic process
RI02_RS18065	COG2514	catechol 2,3-dioxygenase activity
RI02_RS18070	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RI02_RS18070	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RI02_RS18075	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RI02_RS18075	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RI02_RS18085	COG0726	polysaccharide deacetylase
RI02_RS18090	COG1447	Phosphotransferase system cellobiose-specific component IIA
RI02_RS18095	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RI02_RS18100	COG2723	6-phospho-beta-galactosidase activity
RI02_RS18110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RI02_RS18115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RI02_RS18115	COG3711	transcriptional antiterminator
RI02_RS18140	COG1757	Na H antiporter
RI02_RS18145	COG1027	Aspartate ammonia-lyase
RI02_RS18150	COG0252	asparaginase activity
RI02_RS18155	COG1396	sequence-specific DNA binding
RI02_RS18180	COG4842	Belongs to the WXG100 family
RI02_RS18185	COG2195	Cleaves the N-terminal amino acid of tripeptides
RI02_RS18200	COG1737	Transcriptional regulator
RI02_RS18205	COG2084	Dehydrogenase
RI02_RS18215	COG2610	gluconate transmembrane transporter activity
RI02_RS18220	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RI02_RS18245	COG2723	6-phospho-beta-galactosidase activity
RI02_RS18250	COG1263	PTS System
RI02_RS18250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RI02_RS18250	COG2190	(PTS) system
RI02_RS18255	COG3711	transcriptional antiterminator
RI02_RS18260	COG3878	Protein conserved in bacteria
RI02_RS18270	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RI02_RS18275	COG1122	ATPase activity
RI02_RS18280	COG4721	ABC-type cobalt transport system, permease component
RI02_RS18285	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RI02_RS18320	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
RI02_RS18325	COG0778	Nitroreductase
RI02_RS18330	COG1846	Transcriptional regulator
RI02_RS18335	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RI02_RS18340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RI02_RS18345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RI02_RS18350	COG2390	Transcriptional regulator
RI02_RS18360	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RI02_RS18360	COG2755	lipolytic protein G-D-S-L family
RI02_RS18365	COG0477	Major facilitator Superfamily
RI02_RS18370	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RI02_RS18375	COG2226	methyltransferase
RI02_RS18385	COG0561	phosphatase activity
RI02_RS18390	COG0789	Transcriptional regulator
RI02_RS18395	COG0673	inositol 2-dehydrogenase activity
RI02_RS18400	COG0840	transmembrane signaling receptor activity
RI02_RS18405	COG1113	amino acid transport
RI02_RS18410	COG4335	DNA alkylation repair
RI02_RS18420	COG1070	Carbohydrate kinase
RI02_RS18425	COG1737	Transcriptional regulator
RI02_RS18465	COG0583	DNA-binding transcription factor activity
RI02_RS18470	COG1609	Transcriptional regulator
RI02_RS18475	COG2182	Extracellular solute-binding protein
RI02_RS18480	COG1175	transmembrane transport
RI02_RS18485	COG3833	ABC-type maltose transport systems, permease component
RI02_RS18495	COG1874	Beta-galactosidase
RI02_RS18500	COG2851	Citrate transporter
RI02_RS18510	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
RI02_RS18515	COG1131	(ABC) transporter
RI02_RS18520	COG2824	Alkylphosphonate utilization operon protein PhnA
RI02_RS18525	COG1929	Belongs to the glycerate kinase type-1 family
RI02_RS18530	COG2610	gluconate transmembrane transporter activity
RI02_RS18535	COG3835	regulator
RI02_RS18540	COG1309	transcriptional regulator
RI02_RS18555	COG1136	(ABC) transporter
RI02_RS18560	COG0457	Tetratricopeptide repeat
RI02_RS18565	COG3711	transcriptional antiterminator
RI02_RS18570	COG2723	6-phospho-beta-galactosidase activity
RI02_RS18575	COG1263	PTS System
RI02_RS18575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RI02_RS18575	COG2190	(PTS) system
RI02_RS18600	COG0494	nUDIX hydrolase
RI02_RS18615	COG1113	amino acid transport
RI02_RS18620	COG1609	Transcriptional regulator
RI02_RS18625	COG2814	Major facilitator Superfamily
RI02_RS18630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RI02_RS18635	COG2814	Major facilitator Superfamily
RI02_RS18660	COG5444	nuclease activity
RI02_RS18680	COG2723	6-phospho-beta-galactosidase activity
RI02_RS18690	COG2188	Transcriptional regulator
RI02_RS18705	COG0384	phenazine biosynthesis protein PhzF
RI02_RS18710	COG0583	DNA-binding transcription factor activity
RI02_RS18730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RI02_RS18735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RI02_RS18760	COG0210	DNA helicase
RI02_RS18765	COG0210	DNA helicase
RI02_RS18775	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RI02_RS18785	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RI02_RS18795	COG4720	Psort location CytoplasmicMembrane, score
RI02_RS18815	COG0456	acetyltransferase
RI02_RS18820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RI02_RS18825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RI02_RS18830	COG4853	Protein conserved in bacteria
RI02_RS18835	COG4863	YycH protein
RI02_RS18840	COG5002	protein histidine kinase activity
RI02_RS18845	COG0745	RESPONSE REGULATOR receiver
RI02_RS18870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RI02_RS18880	COG2311	Membrane
RI02_RS18885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RI02_RS18890	COG1309	transcriptional regulator
RI02_RS18895	COG2124	cytochrome p450
RI02_RS18900	COG0346	lactoylglutathione lyase activity
RI02_RS18905	COG0305	Participates in initiation and elongation during chromosome replication
RI02_RS18920	COG2819	hydrolase of the alpha beta superfamily
RI02_RS18925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RI02_RS18925	COG2207	Transcriptional regulator
RI02_RS18930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RI02_RS18935	COG2819	hydrolase of the alpha beta superfamily
RI02_RS18940	COG3093	addiction module antidote protein HigA
RI02_RS18945	COG2807	transmembrane transport
RI02_RS18950	COG0359	binds to the 23S rRNA
RI02_RS18955	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
RI02_RS18960	COG4241	membrane
RI02_RS18965	COG1227	inorganic diphosphatase activity
RI02_RS18975	COG1595	DNA-templated transcription, initiation
RI02_RS18985	COG0753	catalase activity
RI02_RS18990	COG0655	NAD(P)H dehydrogenase (quinone) activity
RI02_RS18995	COG0400	carboxylic ester hydrolase activity
RI02_RS19000	COG0346	lactoylglutathione lyase activity
RI02_RS19005	COG1174	glycine betaine transport
RI02_RS19010	COG0517	IMP dehydrogenase activity
RI02_RS19010	COG1125	glycine betaine transport
RI02_RS19015	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RI02_RS19020	COG0629	single-stranded DNA binding
RI02_RS19025	COG0360	Binds together with S18 to 16S ribosomal RNA
RI02_RS19030	COG0012	GTP binding
RI02_RS19035	COG4481	Protein conserved in bacteria
RI02_RS19050	COG3949	Membrane
RI02_RS19060	COG1475	DNA binding
RI02_RS19065	COG1192	Involved in chromosome partitioning
RI02_RS19075	COG1475	DNA binding
RI02_RS19080	COG0357	Ribosomal RNA small subunit methyltransferase G
RI02_RS19085	COG0445	tRNA wobble uridine modification
RI02_RS19090	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RI02_RS19095	COG1847	R3H domain protein
RI02_RS19100	COG0706	membrane insertase activity
RI02_RS19105	COG0594	ribonuclease P activity
RI02_RS19110	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RI02_RS19115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RI02_RS19120	COG0592	DNA-directed DNA polymerase activity
RI02_RS19125	COG2501	S4 domain
RI02_RS19130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RI02_RS19140	COG0187	DNA topoisomerase II activity
RI02_RS19145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RI02_RS19180	COG0516	GMP reductase activity
RI02_RS19180	COG0517	IMP dehydrogenase activity
RI02_RS19185	COG1686	Belongs to the peptidase S11 family
RI02_RS19190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RI02_RS19195	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
RI02_RS19200	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
RI02_RS19205	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RI02_RS19210	COG0840	transmembrane signaling receptor activity
RI02_RS19220	COG1428	Deoxynucleoside kinase
RI02_RS19225	COG1428	Deoxynucleoside kinase
RI02_RS19230	COG1388	LysM domain
RI02_RS19230	COG3858	chitin binding
RI02_RS19235	COG1335	isochorismatase
RI02_RS19240	COG0590	tRNA wobble adenosine to inosine editing
RI02_RS19250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RI02_RS19255	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RI02_RS19260	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO