locus-tag	class	description
I1A55_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I1A55_RS00010	COG0592	DNA-directed DNA polymerase activity
I1A55_RS00015	COG2501	S4 domain
I1A55_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I1A55_RS00030	COG0187	DNA topoisomerase II activity
I1A55_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I1A55_RS00070	COG0517	IMP dehydrogenase activity
I1A55_RS00070	COG0516	GMP reductase activity
I1A55_RS00075	COG1686	Belongs to the peptidase S11 family
I1A55_RS00080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I1A55_RS00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I1A55_RS00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I1A55_RS00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I1A55_RS00100	COG0840	transmembrane signaling receptor activity
I1A55_RS00110	COG1428	Deoxynucleoside kinase
I1A55_RS00115	COG1428	Deoxynucleoside kinase
I1A55_RS00120	COG1388	LysM domain
I1A55_RS00120	COG3858	chitin binding
I1A55_RS00125	COG1335	isochorismatase
I1A55_RS00130	COG0590	tRNA wobble adenosine to inosine editing
I1A55_RS00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I1A55_RS00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I1A55_RS00150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I1A55_RS00195	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I1A55_RS00200	COG3853	Toxic anion resistance protein (TelA)
I1A55_RS00205	COG1982	Orn Lys Arg decarboxylase major
I1A55_RS00210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I1A55_RS00215	COG3870	Protein conserved in bacteria
I1A55_RS00220	COG1728	Protein conserved in bacteria
I1A55_RS00225	COG0470	DNA polymerase III
I1A55_RS00230	COG1774	PSP1 C-terminal conserved region
I1A55_RS00235	COG4467	Involved in initiation control of chromosome replication
I1A55_RS00240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I1A55_RS00245	COG2827	Endonuclease containing a URI domain
I1A55_RS00250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I1A55_RS00255	COG2002	toxin-antitoxin pair type II binding
I1A55_RS00260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I1A55_RS00260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I1A55_RS00265	COG0084	hydrolase, TatD family'
I1A55_RS00270	COG3583	domain protein
I1A55_RS00270	COG3584	3D domain protein
I1A55_RS00275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I1A55_RS00280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I1A55_RS00290	COG4466	Protein conserved in bacteria
I1A55_RS00300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I1A55_RS00305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I1A55_RS00310	COG0251	oxidation-reduction process
I1A55_RS00315	COG2088	sporulation resulting in formation of a cellular spore
I1A55_RS00325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I1A55_RS00330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I1A55_RS00335	COG0193	aminoacyl-tRNA hydrolase activity
I1A55_RS00345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I1A55_RS00350	COG2002	toxin-antitoxin pair type II binding
I1A55_RS00355	COG2244	polysaccharide biosynthetic process
I1A55_RS00360	COG3956	TIGRFAM MazG family protein
I1A55_RS00365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I1A55_RS00380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I1A55_RS00385	COG1098	S1 RNA binding domain
I1A55_RS00400	COG2208	phosphoserine phosphatase activity
I1A55_RS00405	COG2304	oxidoreductase activity
I1A55_RS00410	COG0515	serine threonine protein kinase
I1A55_RS00415	COG0037	tRNA processing
I1A55_RS00420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I1A55_RS00425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1A55_RS00430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I1A55_RS00435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I1A55_RS00440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I1A55_RS00445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I1A55_RS00450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I1A55_RS00455	COG0512	Glutamine amidotransferase of anthranilate synthase
I1A55_RS00460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I1A55_RS00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I1A55_RS00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I1A55_RS00475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I1A55_RS00480	COG1396	sequence-specific DNA binding
I1A55_RS00485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I1A55_RS00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I1A55_RS00570	COG4463	regulation of RNA biosynthetic process
I1A55_RS00575	COG3880	PFAM UvrB UvrC protein
I1A55_RS00580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I1A55_RS00585	COG0542	response to heat
I1A55_RS00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I1A55_RS00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I1A55_RS00600	COG4956	integral membrane protein (PIN domain superfamily)
I1A55_RS00605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I1A55_RS00610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I1A55_RS00615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I1A55_RS00620	COG1045	serine acetyltransferase
I1A55_RS00625	COG0215	cysteine-tRNA ligase activity
I1A55_RS00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I1A55_RS00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I1A55_RS00640	COG3688	RNA-binding protein containing a PIN domain
I1A55_RS00645	COG1595	DNA-templated transcription, initiation
I1A55_RS00650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I1A55_RS00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I1A55_RS00660	COG0250	Participates in transcription elongation, termination and antitermination
I1A55_RS00670	COG0081	regulation of translation
I1A55_RS00675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I1A55_RS00680	COG0222	ribosome binding
I1A55_RS00685	COG2813	Specifically methylates the guanine in position
I1A55_RS00690	COG0085	RNA polymerase activity
I1A55_RS00695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I1A55_RS00700	COG1358	cellular component organization or biogenesis
I1A55_RS00705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I1A55_RS00710	COG0049	tRNA binding
I1A55_RS00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I1A55_RS00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I1A55_RS00725	COG0596	Alpha beta hydrolase
I1A55_RS00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I1A55_RS00740	COG0088	Forms part of the polypeptide exit tunnel
I1A55_RS00745	COG0089	rRNA binding
I1A55_RS00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I1A55_RS00755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I1A55_RS00760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I1A55_RS00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I1A55_RS00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I1A55_RS00775	COG0255	Belongs to the universal ribosomal protein uL29 family
I1A55_RS00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I1A55_RS00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I1A55_RS00790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I1A55_RS00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I1A55_RS00800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I1A55_RS00805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I1A55_RS00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I1A55_RS00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I1A55_RS00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I1A55_RS00825	COG1841	ribosomal large subunit assembly
I1A55_RS00830	COG0200	Binds to the 23S rRNA
I1A55_RS00835	COG0201	protein transport
I1A55_RS00840	COG0563	adenylate kinase activity
I1A55_RS00845	COG0024	Methionine aminopeptidase
I1A55_RS00850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I1A55_RS00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I1A55_RS00860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I1A55_RS00865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I1A55_RS00870	COG0202	RNA polymerase activity
I1A55_RS00875	COG0203	ribosomal protein L17
I1A55_RS00880	COG1122	ATPase activity
I1A55_RS00885	COG1122	ATPase activity
I1A55_RS00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I1A55_RS00895	COG0101	tRNA pseudouridine synthase activity
I1A55_RS00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I1A55_RS00905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I1A55_RS00910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I1A55_RS00935	COG1136	(ABC) transporter
I1A55_RS00955	COG0860	N-Acetylmuramoyl-L-alanine amidase
I1A55_RS00960	COG0489	protein tyrosine kinase activity
I1A55_RS00970	COG2194	sulfuric ester hydrolase activity
I1A55_RS00975	COG0726	polysaccharide deacetylase
I1A55_RS01005	COG0659	secondary active sulfate transmembrane transporter activity
I1A55_RS01010	COG0385	Bile acid
I1A55_RS01015	COG3876	Protein conserved in bacteria
I1A55_RS01020	COG1472	Belongs to the glycosyl hydrolase 3 family
I1A55_RS01025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I1A55_RS01030	COG1263	PTS System
I1A55_RS01030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A55_RS01035	COG1737	Transcriptional regulator
I1A55_RS01040	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I1A55_RS01080	COG1595	DNA-templated transcription, initiation
I1A55_RS01085	COG5662	AntiSigma factor
I1A55_RS01090	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I1A55_RS01095	COG4856	YbbR-like protein
I1A55_RS01100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I1A55_RS01105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I1A55_RS01125	COG1131	(ABC) transporter
I1A55_RS01135	COG1136	(ABC) transporter
I1A55_RS01145	COG1695	Transcriptional regulator
I1A55_RS01160	COG0535	radical SAM domain protein
I1A55_RS01165	COG1266	CAAX protease self-immunity
I1A55_RS01170	COG1131	(ABC) transporter
I1A55_RS01180	COG1413	lyase activity
I1A55_RS01185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1A55_RS01195	COG2311	Membrane
I1A55_RS01215	COG1476	TRANSCRIPTIONal
I1A55_RS01225	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I1A55_RS01230	COG2207	Transcriptional regulator
I1A55_RS01245	COG1131	(ABC) transporter
I1A55_RS01260	COG1113	amino acid transport
I1A55_RS01265	COG0584	glycerophosphoryl diester phosphodiesterase
I1A55_RS01270	COG2271	Major facilitator Superfamily
I1A55_RS01280	COG1331	Highly conserved protein containing a thioredoxin domain
I1A55_RS01285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1A55_RS01300	COG0640	Transcriptional regulator
I1A55_RS01315	COG1937	Protein conserved in bacteria
I1A55_RS01320	COG2210	Belongs to the sulfur carrier protein TusA family
I1A55_RS01330	COG0425	Belongs to the sulfur carrier protein TusA family
I1A55_RS01330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I1A55_RS01335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I1A55_RS01335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I1A55_RS01340	COG0425	Belongs to the sulfur carrier protein TusA family
I1A55_RS01345	COG0730	response to heat
I1A55_RS01355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I1A55_RS01360	COG2814	Major facilitator Superfamily
I1A55_RS01375	COG1846	Transcriptional regulator
I1A55_RS01380	COG1683	Conserved Protein
I1A55_RS01390	COG0656	L-ascorbic acid biosynthetic process
I1A55_RS01395	COG0371	Dehydrogenase
I1A55_RS01400	COG1054	Belongs to the UPF0176 family
I1A55_RS01405	COG0531	amino acid
I1A55_RS01415	COG3711	transcriptional antiterminator
I1A55_RS01420	COG2190	(PTS) system
I1A55_RS01420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A55_RS01420	COG1263	PTS System
I1A55_RS01425	COG2723	6-phospho-beta-galactosidase activity
I1A55_RS01450	COG3711	transcriptional antiterminator
I1A55_RS01450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A55_RS01455	COG1940	carbohydrate kinase activity
I1A55_RS01460	COG0383	alpha-mannosidase activity
I1A55_RS01465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I1A55_RS01470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I1A55_RS01480	COG1404	Belongs to the peptidase S8 family
I1A55_RS01495	COG0833	amino acid
I1A55_RS01500	COG2040	homocysteine
I1A55_RS01505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I1A55_RS01525	COG2814	Major facilitator Superfamily
I1A55_RS01530	COG0456	acetyltransferase
I1A55_RS01545	COG1404	Belongs to the peptidase S8 family
I1A55_RS01555	COG1309	transcriptional regulator
I1A55_RS01560	COG1917	Cupin 2, conserved barrel domain protein
I1A55_RS01565	COG1846	Transcriptional regulator
I1A55_RS01570	COG0318	PFAM AMP-dependent synthetase and ligase
I1A55_RS01575	COG0531	amino acid
I1A55_RS01585	COG0596	Alpha beta hydrolase
I1A55_RS01590	COG1115	amino acid carrier protein
I1A55_RS01595	COG2066	Belongs to the glutaminase family
I1A55_RS01600	COG4191	Histidine kinase
I1A55_RS01605	COG0784	Response regulator, receiver
I1A55_RS01610	COG1405	negative regulation of cell septum assembly
I1A55_RS01610	COG3012	SEC-C Motif Domain Protein
I1A55_RS01620	COG0667	Aldo Keto reductase
I1A55_RS01625	COG3290	protein histidine kinase activity
I1A55_RS01630	COG3279	Response regulator of the LytR AlgR family
I1A55_RS01635	COG4555	ABC transporter
I1A55_RS01640	COG1668	transmembrane transport
I1A55_RS01660	COG3773	Cell wall hydrolase
I1A55_RS01665	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS01675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A55_RS01680	COG2310	stress, protein
I1A55_RS01685	COG2310	stress, protein
I1A55_RS01690	COG2310	stress, protein
I1A55_RS01695	COG0861	Integral membrane protein TerC family
I1A55_RS01725	COG3853	Toxic anion resistance protein (TelA)
I1A55_RS01730	COG0517	IMP dehydrogenase activity
I1A55_RS01730	COG4175	Glycine betaine
I1A55_RS01735	COG4176	ABC-type proline glycine betaine transport system permease component
I1A55_RS01740	COG2113	Glycine betaine
I1A55_RS01755	COG1473	amidohydrolase
I1A55_RS01760	COG1288	antiporter activity
I1A55_RS01765	COG0039	L-malate dehydrogenase activity
I1A55_RS01770	COG1620	l-lactate permease
I1A55_RS01775	COG1609	Transcriptional regulator
I1A55_RS01780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I1A55_RS01785	COG0561	phosphatase activity
I1A55_RS01790	COG0673	inositol 2-dehydrogenase activity
I1A55_RS01795	COG0738	Major facilitator superfamily
I1A55_RS01800	COG1280	lysine exporter protein (LysE YggA)
I1A55_RS01815	COG3403	YqcI/YcgG family
I1A55_RS01820	COG1113	amino acid transport
I1A55_RS01825	COG3665	Urea carboxylase-associated protein
I1A55_RS01830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I1A55_RS01840	COG1012	belongs to the aldehyde dehydrogenase family
I1A55_RS01845	COG0710	3-dehydroquinate dehydratase activity
I1A55_RS01850	COG0028	Belongs to the TPP enzyme family
I1A55_RS01860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I1A55_RS01865	COG2271	Major facilitator Superfamily
I1A55_RS01880	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I1A55_RS01885	COG2226	methyltransferase
I1A55_RS01890	COG0583	DNA-binding transcription factor activity
I1A55_RS01895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1A55_RS01900	COG3458	cephalosporin-C deacetylase activity
I1A55_RS01910	COG3541	Predicted nucleotidyltransferase
I1A55_RS01915	COG0506	proline dehydrogenase activity
I1A55_RS01920	COG1012	belongs to the aldehyde dehydrogenase family
I1A55_RS01925	COG2508	Transcriptional regulator
I1A55_RS01930	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I1A55_RS01935	COG0765	amino acid transport
I1A55_RS01940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1A55_RS01950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I1A55_RS01955	COG1522	sequence-specific DNA binding
I1A55_RS01960	COG2746	aminoglycoside 3-N-acetyltransferase activity
I1A55_RS01970	COG3290	protein histidine kinase activity
I1A55_RS01970	COG0840	transmembrane signaling receptor activity
I1A55_RS01975	COG3209	COG3209 Rhs family protein
I1A55_RS01995	COG3842	ATPase activity
I1A55_RS02000	COG1176	ABC-type spermidine putrescine transport system, permease component I
I1A55_RS02010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A55_RS02015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A55_RS02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A55_RS02035	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I1A55_RS02040	COG0697	spore germination
I1A55_RS02045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I1A55_RS02055	COG2207	Transcriptional regulator
I1A55_RS02055	COG3708	Transcriptional regulator
I1A55_RS02065	COG2364	Membrane
I1A55_RS02070	COG1126	abc transporter atp-binding protein
I1A55_RS02075	COG0765	amino acid transport
I1A55_RS02080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1A55_RS02085	COG0833	amino acid
I1A55_RS02090	COG3104	oligopeptide transport
I1A55_RS02095	COG5434	Belongs to the glycosyl hydrolase 28 family
I1A55_RS02100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A55_RS02105	COG0456	acetyltransferase
I1A55_RS02110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1A55_RS02115	COG0765	amino acid transport
I1A55_RS02120	COG1126	abc transporter atp-binding protein
I1A55_RS02125	COG1473	amidohydrolase
I1A55_RS02130	COG2079	MmgE PrpD family protein
I1A55_RS02135	COG0745	RESPONSE REGULATOR receiver
I1A55_RS02140	COG3850	Histidine kinase
I1A55_RS02140	COG5002	protein histidine kinase activity
I1A55_RS02145	COG1366	Belongs to the anti-sigma-factor antagonist family
I1A55_RS02150	COG0527	aspartate kinase activity
I1A55_RS02155	COG2814	Major facilitator Superfamily
I1A55_RS02160	COG1309	transcriptional regulator
I1A55_RS02170	COG0640	Transcriptional regulator
I1A55_RS02180	COG0583	DNA-binding transcription factor activity
I1A55_RS02185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I1A55_RS02190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I1A55_RS02195	COG0531	amino acid
I1A55_RS02200	COG1012	belongs to the aldehyde dehydrogenase family
I1A55_RS02205	COG2249	NAD(P)H dehydrogenase (quinone) activity
I1A55_RS02210	COG4549	nuclear export factor GLE1
I1A55_RS02215	COG1276	copper resistance
I1A55_RS02215	COG2372	response to copper ion
I1A55_RS02220	COG2213	PTS system mannitol-specific
I1A55_RS02225	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A55_RS02230	COG0246	Mannitol dehydrogenase
I1A55_RS02235	COG0840	transmembrane signaling receptor activity
I1A55_RS02270	COG0346	lactoylglutathione lyase activity
I1A55_RS02280	COG0561	phosphatase activity
I1A55_RS02285	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I1A55_RS02290	COG1914	H( )-stimulated, divalent metal cation uptake system
I1A55_RS02295	COG4336	lyase activity
I1A55_RS02300	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I1A55_RS02305	COG1984	allophanate hydrolase subunit 2
I1A55_RS02310	COG1414	Transcriptional regulator
I1A55_RS02315	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I1A55_RS02320	COG2755	lipolytic protein G-D-S-L family
I1A55_RS02330	COG3711	transcriptional antiterminator
I1A55_RS02335	COG2226	methyltransferase
I1A55_RS02340	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS02345	COG3871	stress protein (general stress protein 26)
I1A55_RS02365	COG2814	Major facilitator Superfamily
I1A55_RS02370	COG1802	Transcriptional regulator
I1A55_RS02375	COG1917	Cupin 2, conserved barrel domain protein
I1A55_RS02375	COG2207	Transcriptional regulator
I1A55_RS02380	COG0697	spore germination
I1A55_RS02385	COG0473	3-isopropylmalate dehydrogenase activity
I1A55_RS02390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I1A55_RS02390	COG0551	DNA topoisomerase type I activity
I1A55_RS02395	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I1A55_RS02400	COG3706	GGDEF domain
I1A55_RS02405	COG5298	Protein conserved in bacteria
I1A55_RS02410	COG1215	transferase activity, transferring glycosyl groups
I1A55_RS02420	COG0531	amino acid
I1A55_RS02425	COG0028	Belongs to the TPP enzyme family
I1A55_RS02430	COG5444	nuclease activity
I1A55_RS02450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I1A55_RS02455	COG1914	H( )-stimulated, divalent metal cation uptake system
I1A55_RS02460	COG2261	transglycosylase associated protein
I1A55_RS02465	COG2217	Heavy metal translocating P-type atpase
I1A55_RS02470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I1A55_RS02475	COG3290	protein histidine kinase activity
I1A55_RS02480	COG4565	transcriptional regulatory protein
I1A55_RS02485	COG1301	dicarboxylic acid transport
I1A55_RS02490	COG0628	permease
I1A55_RS02495	COG1301	dicarboxylic acid transport
I1A55_RS02500	COG1131	(ABC) transporter
I1A55_RS02505	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I1A55_RS02520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1A55_RS02525	COG1181	Belongs to the D-alanine--D-alanine ligase family
I1A55_RS02530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I1A55_RS02545	COG0513	Belongs to the DEAD box helicase family
I1A55_RS02550	COG3402	PFAM membrane-flanked domain
I1A55_RS02555	COG3428	Bacterial PH domain
I1A55_RS02560	COG0705	Rhomboid family
I1A55_RS02565	COG0736	holo-[acyl-carrier-protein] synthase activity
I1A55_RS02570	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I1A55_RS02575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I1A55_RS02580	COG0864	Transcriptional regulator
I1A55_RS02585	COG2337	Toxic component of a toxin-antitoxin (TA) module
I1A55_RS02590	COG1366	Belongs to the anti-sigma-factor antagonist family
I1A55_RS02595	COG1366	Belongs to the anti-sigma-factor antagonist family
I1A55_RS02600	COG2172	sigma factor antagonist activity
I1A55_RS02605	COG2208	phosphoserine phosphatase activity
I1A55_RS02610	COG1366	Belongs to the anti-sigma-factor antagonist family
I1A55_RS02615	COG2172	sigma factor antagonist activity
I1A55_RS02620	COG1191	sigma factor activity
I1A55_RS02625	COG2208	phosphoserine phosphatase activity
I1A55_RS02630	COG2183	response to ionizing radiation
I1A55_RS02640	COG3091	SprT-like family
I1A55_RS02645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I1A55_RS02650	COG0022	dehydrogenase e1 component
I1A55_RS02655	COG0508	dehydrogenase complex catalyzes the overall conversion of
I1A55_RS02660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1A55_RS02710	COG1278	Cold shock
I1A55_RS02725	COG2190	(PTS) system
I1A55_RS02725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A55_RS02725	COG1263	PTS System
I1A55_RS02730	COG3394	polysaccharide catabolic process
I1A55_RS02735	COG3711	transcriptional antiterminator
I1A55_RS02740	COG1064	alcohol dehydrogenase
I1A55_RS02745	COG0789	Transcriptional regulator
I1A55_RS02765	COG0477	Major facilitator Superfamily
I1A55_RS02770	COG0657	acetylesterase activity
I1A55_RS02780	COG4221	oxidoreductase activity
I1A55_RS02790	COG0252	asparaginase activity
I1A55_RS02795	COG2267	carboxylic ester hydrolase activity
I1A55_RS02810	COG2814	Major facilitator Superfamily
I1A55_RS02815	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
I1A55_RS02820	COG2409	Drug exporters of the RND superfamily
I1A55_RS02825	COG4585	Histidine kinase
I1A55_RS02830	COG2197	response regulator
I1A55_RS02875	COG1309	transcriptional regulator
I1A55_RS02880	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I1A55_RS02885	COG1846	Transcriptional regulator
I1A55_RS02890	COG0778	Nitroreductase
I1A55_RS02905	COG1396	sequence-specific DNA binding
I1A55_RS02915	COG0456	acetyltransferase
I1A55_RS02925	COG4122	O-methyltransferase activity
I1A55_RS02935	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I1A55_RS02940	COG0697	spore germination
I1A55_RS02950	COG1301	dicarboxylic acid transport
I1A55_RS02990	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I1A55_RS02995	COG0802	atpase or kinase
I1A55_RS03000	COG1214	PFAM Peptidase M22, glycoprotease
I1A55_RS03005	COG0456	acetyltransferase
I1A55_RS03010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I1A55_RS03015	COG0488	(ABC) transporter
I1A55_RS03020	COG0315	cyclic pyranopterin monophosphate synthase activity
I1A55_RS03025	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I1A55_RS03030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I1A55_RS03035	COG0805	protein transport
I1A55_RS03050	COG1266	CAAX protease self-immunity
I1A55_RS03055	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I1A55_RS03060	COG0459	protein refolding
I1A55_RS03065	COG1846	Transcriptional regulator
I1A55_RS03070	COG2808	Putative FMN-binding domain
I1A55_RS03075	COG1876	peptidase activity
I1A55_RS03100	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I1A55_RS03105	COG0823	Involved in the tonB-independent uptake of proteins
I1A55_RS03115	COG2132	Multicopper oxidase
I1A55_RS03120	COG1113	amino acid transport
I1A55_RS03125	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I1A55_RS03130	COG0714	Associated with various cellular activities
I1A55_RS03135	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I1A55_RS03140	COG1305	Transglutaminase-like
I1A55_RS03145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I1A55_RS03145	COG0519	Catalyzes the synthesis of GMP from XMP
I1A55_RS03165	COG1674	ftsk spoiiie
I1A55_RS03190	COG3550	peptidyl-serine autophosphorylation
I1A55_RS03200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I1A55_RS03210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I1A55_RS03260	COG1595	DNA-templated transcription, initiation
I1A55_RS03270	COG2814	Major facilitator Superfamily
I1A55_RS03275	COG0583	DNA-binding transcription factor activity
I1A55_RS03280	COG2252	PERMEase
I1A55_RS03290	COG5583	Uncharacterized small protein (DUF2292)
I1A55_RS03295	COG3064	Membrane
I1A55_RS03300	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I1A55_RS03310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I1A55_RS03315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I1A55_RS03320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I1A55_RS03325	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I1A55_RS03330	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I1A55_RS03335	COG0047	phosphoribosylformylglycinamidine synthase activity
I1A55_RS03340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I1A55_RS03345	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I1A55_RS03350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I1A55_RS03355	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I1A55_RS03360	COG0138	bifunctional purine biosynthesis protein purh
I1A55_RS03365	COG0151	Belongs to the GarS family
I1A55_RS03385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I1A55_RS03390	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I1A55_RS03395	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I1A55_RS03400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I1A55_RS03410	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I1A55_RS03415	COG4496	protein, YerC YecD
I1A55_RS03425	COG0069	glutamate synthase activity
I1A55_RS03440	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I1A55_RS03445	COG0210	DNA helicase
I1A55_RS03450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I1A55_RS03455	COG4851	CamS sex pheromone cAM373 precursor
I1A55_RS03460	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I1A55_RS03465	COG1285	pathogenesis
I1A55_RS03470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I1A55_RS03475	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I1A55_RS03480	COG0154	amidase activity
I1A55_RS03485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I1A55_RS03490	COG1309	transcriptional regulator
I1A55_RS03495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I1A55_RS03500	COG1957	nucleoside hydrolase
I1A55_RS03505	COG1597	lipid kinase activity
I1A55_RS03510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I1A55_RS03535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I1A55_RS03550	COG1959	2 iron, 2 sulfur cluster binding
I1A55_RS03555	COG0492	ferredoxin-NADP+ reductase activity
I1A55_RS03570	COG1486	melibiose metabolic process
I1A55_RS03580	COG2211	Major facilitator Superfamily
I1A55_RS03610	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I1A55_RS03615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1A55_RS03620	COG1442	glycosyl transferase family 8
I1A55_RS03625	COG1216	Glycosyl transferase, family 2
I1A55_RS03630	COG1442	glycosyl transferase family 8
I1A55_RS03635	COG2223	nitrite transmembrane transporter activity
I1A55_RS03645	COG0471	metal ion transport
I1A55_RS03660	COG0071	Belongs to the small heat shock protein (HSP20) family
I1A55_RS03675	COG0531	amino acid
I1A55_RS03680	COG0457	Tetratricopeptide repeat
I1A55_RS03680	COG0463	Glycosyl transferase, family 2
I1A55_RS03685	COG0488	(ABC) transporter
I1A55_RS03690	COG1469	GTP cyclohydrolase I activity
I1A55_RS03695	COG0789	Transcriptional regulator
I1A55_RS03700	COG2814	Major facilitator Superfamily
I1A55_RS03705	COG0488	(ABC) transporter
I1A55_RS03710	COG0513	Belongs to the DEAD box helicase family
I1A55_RS03715	COG2130	NADP-dependent
I1A55_RS03735	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I1A55_RS03735	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I1A55_RS03740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I1A55_RS03750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I1A55_RS03750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I1A55_RS03760	COG3290	protein histidine kinase activity
I1A55_RS03765	COG4565	transcriptional regulatory protein
I1A55_RS03770	COG3181	Tripartite tricarboxylate transporter family receptor
I1A55_RS03775	COG2851	Citrate transporter
I1A55_RS03785	COG3479	Phenolic acid decarboxylase
I1A55_RS03790	COG1695	Transcriptional regulator
I1A55_RS03795	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I1A55_RS03805	COG1254	Belongs to the acylphosphatase family
I1A55_RS03810	COG2258	MOSC domain
I1A55_RS03825	COG0024	Methionine aminopeptidase
I1A55_RS03830	COG1263	PTS System
I1A55_RS03830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A55_RS03835	COG3739	integral membrane protein
I1A55_RS03850	COG1368	sulfuric ester hydrolase activity
I1A55_RS03855	COG0076	glutamate decarboxylase activity
I1A55_RS03870	COG1263	PTS System
I1A55_RS03870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A55_RS03875	COG0366	Alpha amylase catalytic
I1A55_RS03880	COG2188	Transcriptional regulator
I1A55_RS03890	COG0737	Belongs to the 5'-nucleotidase family
I1A55_RS03895	COG0693	protein deglycase activity
I1A55_RS03900	COG4840	Belongs to the UPF0435 family
I1A55_RS03905	COG1115	amino acid carrier protein
I1A55_RS03910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I1A55_RS03915	COG4980	gas vesicle protein
I1A55_RS03920	COG1295	ribonuclease BN
I1A55_RS03930	COG0477	Major facilitator Superfamily
I1A55_RS03940	COG0387	Pfam Sodium calcium exchanger
I1A55_RS03950	COG0217	transcriptional regulatory protein
I1A55_RS03960	COG0668	transmembrane transport
I1A55_RS03965	COG0535	radical SAM domain protein
I1A55_RS03975	COG0726	polysaccharide deacetylase
I1A55_RS03985	COG0598	Magnesium transport protein CorA
I1A55_RS03995	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I1A55_RS04000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I1A55_RS04020	COG0789	Transcriptional regulator
I1A55_RS04025	COG2814	Major facilitator Superfamily
I1A55_RS04075	COG2076	Multidrug Resistance protein
I1A55_RS04080	COG2076	Multidrug Resistance protein
I1A55_RS04085	COG1309	transcriptional regulator
I1A55_RS04095	COG4637	Psort location Cytoplasmic, score
I1A55_RS04100	COG2755	lipolytic protein G-D-S-L family
I1A55_RS04105	COG0492	ferredoxin-NADP+ reductase activity
I1A55_RS04110	COG2169	Transcriptional regulator
I1A55_RS04115	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I1A55_RS04120	COG1132	(ABC) transporter
I1A55_RS04125	COG1742	UPF0060 membrane protein
I1A55_RS04130	COG1595	DNA-templated transcription, initiation
I1A55_RS04150	COG2318	DinB family
I1A55_RS04160	COG1846	Transcriptional regulator
I1A55_RS04165	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I1A55_RS04165	COG0392	lysyltransferase activity
I1A55_RS04185	COG0778	Nitroreductase
I1A55_RS04200	COG1090	epimerase
I1A55_RS04205	COG2137	regulation of response to DNA damage stimulus
I1A55_RS04230	COG0463	Glycosyl transferase, family 2
I1A55_RS04235	COG4485	Bacterial membrane protein, YfhO
I1A55_RS04240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1A55_RS04255	COG2140	Oxalate decarboxylase
I1A55_RS04265	COG1191	sigma factor activity
I1A55_RS04275	COG1988	membrane-bound metal-dependent
I1A55_RS04280	COG1194	a g-specific adenine glycosylase
I1A55_RS04290	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS04305	COG3557	Belongs to the UPF0374 family
I1A55_RS04310	COG1132	(ABC) transporter
I1A55_RS04315	COG0444	Belongs to the ABC transporter superfamily
I1A55_RS04320	COG4608	Belongs to the ABC transporter superfamily
I1A55_RS04325	COG0747	negative chemotaxis
I1A55_RS04330	COG0601	transmembrane transport
I1A55_RS04335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A55_RS04340	COG4129	membrane
I1A55_RS04345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I1A55_RS04350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I1A55_RS04355	COG0735	belongs to the Fur family
I1A55_RS04500	COG1368	sulfuric ester hydrolase activity
I1A55_RS04505	COG0681	Belongs to the peptidase S26 family
I1A55_RS04510	COG2873	o-acetylhomoserine
I1A55_RS04520	COG1116	anion transmembrane transporter activity
I1A55_RS04525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1A55_RS04530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1A55_RS04545	COG1131	(ABC) transporter
I1A55_RS04575	COG3382	B3 4 domain protein
I1A55_RS04580	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I1A55_RS04590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I1A55_RS04595	COG2766	serine protein kinase
I1A55_RS04600	COG2718	Belongs to the UPF0229 family
I1A55_RS04605	COG1566	PFAM secretion protein HlyD family protein
I1A55_RS04610	COG2814	Major facilitator Superfamily
I1A55_RS04615	COG0655	NAD(P)H dehydrogenase (quinone) activity
I1A55_RS04625	COG1278	Cold shock
I1A55_RS04630	COG3706	GGDEF domain
I1A55_RS04655	COG5577	PFAM Coat F domain
I1A55_RS04660	COG5002	protein histidine kinase activity
I1A55_RS04665	COG4085	toxin activity
I1A55_RS04665	COG0737	Belongs to the 5'-nucleotidase family
I1A55_RS04665	COG1525	nuclease
I1A55_RS04670	COG3764	Sortase (surface protein transpeptidase)
I1A55_RS04675	COG0564	pseudouridine synthase activity
I1A55_RS04685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I1A55_RS04690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1A55_RS04690	COG3153	acetyltransferase
I1A55_RS04710	COG3835	regulator
I1A55_RS04715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I1A55_RS04720	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I1A55_RS04725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I1A55_RS04730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I1A55_RS04735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I1A55_RS04740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I1A55_RS04745	COG4585	Histidine kinase
I1A55_RS04745	COG2203	Gaf domain
I1A55_RS04750	COG2197	response regulator
I1A55_RS04765	COG0753	catalase activity
I1A55_RS04770	COG1959	2 iron, 2 sulfur cluster binding
I1A55_RS04775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I1A55_RS04775	COG1017	nitric oxide dioxygenase activity
I1A55_RS04780	COG2719	SpoVR family
I1A55_RS04785	COG1785	Belongs to the alkaline phosphatase family
I1A55_RS04790	COG1388	LysM domain
I1A55_RS04790	COG0791	NLP P60 protein
I1A55_RS04795	COG0531	amino acid
I1A55_RS04810	COG1595	DNA-templated transcription, initiation
I1A55_RS04815	COG0204	Acyl-transferase
I1A55_RS04820	COG1253	flavin adenine dinucleotide binding
I1A55_RS04825	COG0789	Transcriptional regulator
I1A55_RS04830	COG1253	flavin adenine dinucleotide binding
I1A55_RS04845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I1A55_RS04850	COG0584	glycerophosphoryl diester phosphodiesterase
I1A55_RS04860	COG0668	transmembrane transport
I1A55_RS04865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I1A55_RS04870	COG0726	polysaccharide deacetylase
I1A55_RS04875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I1A55_RS04880	COG0589	response to stress
I1A55_RS04885	COG1132	(ABC) transporter
I1A55_RS04890	COG1132	(ABC) transporter
I1A55_RS04895	COG0702	epimerase
I1A55_RS04905	COG3842	ATPase activity
I1A55_RS04910	COG2508	Transcriptional regulator
I1A55_RS04920	COG0189	ligase activity
I1A55_RS04925	COG0189	ligase activity
I1A55_RS04930	COG4399	Belongs to the UPF0754 family
I1A55_RS04935	COG3679	Belongs to the UPF0342 family
I1A55_RS04940	COG0561	phosphatase activity
I1A55_RS04945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I1A55_RS04955	COG0475	glutathione-regulated potassium exporter activity
I1A55_RS04960	COG0490	domain, Protein
I1A55_RS04965	COG1024	Enoyl-CoA hydratase
I1A55_RS04975	COG0420	3'-5' exonuclease activity
I1A55_RS04980	COG4717	serine-type aminopeptidase activity
I1A55_RS04985	COG3481	metal-dependent phosphohydrolase, HD sub domain
I1A55_RS04995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I1A55_RS05020	COG1846	Transcriptional regulator
I1A55_RS05025	COG4980	gas vesicle protein
I1A55_RS05040	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I1A55_RS05045	COG0537	adenosine 5'-monophosphoramidase activity
I1A55_RS05050	COG1131	(ABC) transporter
I1A55_RS05055	COG4473	ABC transporter
I1A55_RS05065	COG1473	amidohydrolase
I1A55_RS05075	COG2329	Antibiotic biosynthesis monooxygenase
I1A55_RS05080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1A55_RS05085	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I1A55_RS05090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1A55_RS05095	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I1A55_RS05100	COG1309	transcriptional regulator
I1A55_RS05105	COG1511	domain protein
I1A55_RS05110	COG1363	Peptidase, m42
I1A55_RS05115	COG1301	dicarboxylic acid transport
I1A55_RS05125	COG1234	tRNA 3'-trailer cleavage
I1A55_RS05130	COG0095	Lipoate-protein ligase
I1A55_RS05135	COG0318	PFAM AMP-dependent synthetase and ligase
I1A55_RS05145	COG0501	Belongs to the peptidase M48B family
I1A55_RS05150	COG1404	Belongs to the peptidase S8 family
I1A55_RS05155	COG0406	alpha-ribazole phosphatase activity
I1A55_RS05160	COG0840	transmembrane signaling receptor activity
I1A55_RS05165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I1A55_RS05165	COG0723	plastoquinol--plastocyanin reductase activity
I1A55_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS05180	COG4903	ComK protein
I1A55_RS05195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I1A55_RS05200	COG2814	Major facilitator Superfamily
I1A55_RS05205	COG2732	(Barnase) inhibitor
I1A55_RS05210	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A55_RS05215	COG4605	iron ion homeostasis
I1A55_RS05220	COG4604	ABC transporter, ATP-binding protein
I1A55_RS05225	COG4607	ABC-type enterochelin transport system periplasmic component
I1A55_RS05230	COG1316	TRANSCRIPTIONal
I1A55_RS05245	COG0398	Pfam SNARE associated Golgi protein
I1A55_RS05250	COG0681	Belongs to the peptidase S26 family
I1A55_RS05255	COG3180	Ammonia monooxygenase
I1A55_RS05270	COG2259	Doxx family
I1A55_RS05275	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I1A55_RS05280	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I1A55_RS05285	COG1074	ATP-dependent DNA helicase activity
I1A55_RS05290	COG0420	3'-5' exonuclease activity
I1A55_RS05295	COG0419	ATPase involved in DNA repair
I1A55_RS05300	COG1403	HNH endonuclease
I1A55_RS05340	COG5337	Spore coat protein CotH
I1A55_RS05350	COG0179	Fumarylacetoacetate (FAA) hydrolase
I1A55_RS05365	COG0367	asparagine synthase
I1A55_RS05380	COG1562	ergosterol biosynthetic process
I1A55_RS05385	COG0534	Mate efflux family protein
I1A55_RS05390	COG1917	Cupin 2, conserved barrel domain protein
I1A55_RS05390	COG2207	Transcriptional regulator
I1A55_RS05415	COG0076	glutamate decarboxylase activity
I1A55_RS05450	COG1410	methionine synthase
I1A55_RS05450	COG0646	methionine synthase
I1A55_RS05455	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I1A55_RS05455	COG0646	methionine synthase
I1A55_RS05460	COG1666	GTP binding
I1A55_RS05465	COG2996	Protein conserved in bacteria
I1A55_RS05470	COG1744	ABC transporter substrate-binding protein PnrA-like
I1A55_RS05475	COG0840	transmembrane signaling receptor activity
I1A55_RS05480	COG1307	EDD domain protein, DegV family
I1A55_RS05485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I1A55_RS05505	COG0561	phosphatase activity
I1A55_RS05510	COG1073	alpha beta
I1A55_RS05515	COG2151	metal-sulfur cluster biosynthetic enzyme
I1A55_RS05520	COG0277	FAD linked oxidase domain protein
I1A55_RS05525	COG2271	Major facilitator Superfamily
I1A55_RS05530	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I1A55_RS05535	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I1A55_RS05540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I1A55_RS05545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I1A55_RS05550	COG0505	Belongs to the CarA family
I1A55_RS05555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I1A55_RS05560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I1A55_RS05570	COG2814	Major facilitator Superfamily
I1A55_RS05580	COG2267	carboxylic ester hydrolase activity
I1A55_RS05590	COG1744	ABC transporter substrate-binding protein PnrA-like
I1A55_RS05605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I1A55_RS05610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1A55_RS05615	COG5504	Zn-dependent protease
I1A55_RS05620	COG0444	Belongs to the ABC transporter superfamily
I1A55_RS05625	COG4608	Belongs to the ABC transporter superfamily
I1A55_RS05635	COG0601	transmembrane transport
I1A55_RS05640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A55_RS05650	COG0180	Tryptophanyl-tRNA synthetase
I1A55_RS05655	COG4166	transmembrane transport
I1A55_RS05660	COG0601	transmembrane transport
I1A55_RS05665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A55_RS05670	COG0444	Belongs to the ABC transporter superfamily
I1A55_RS05675	COG4608	Belongs to the ABC transporter superfamily
I1A55_RS05685	COG0456	acetyltransferase
I1A55_RS05690	COG1393	Belongs to the ArsC family
I1A55_RS05695	COG0861	Integral membrane protein TerC family
I1A55_RS05700	COG4862	establishment of competence for transformation
I1A55_RS05705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I1A55_RS05715	COG1164	Oligoendopeptidase f
I1A55_RS05725	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I1A55_RS05730	COG2346	COG2346, Truncated hemoglobins
I1A55_RS05735	COG0741	lytic transglycosylase activity
I1A55_RS05740	COG4116	CYTH
I1A55_RS05750	COG2357	RelA SpoT domain protein
I1A55_RS05755	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I1A55_RS05760	COG0564	pseudouridine synthase activity
I1A55_RS05765	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I1A55_RS05770	COG0569	domain protein
I1A55_RS05770	COG0475	glutathione-regulated potassium exporter activity
I1A55_RS05775	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I1A55_RS05780	COG0352	thiamine-phosphate diphosphorylase activity
I1A55_RS05790	COG2104	thiamine diphosphate biosynthetic process
I1A55_RS05795	COG2022	thiamine diphosphate biosynthetic process
I1A55_RS05800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I1A55_RS05805	COG0351	phosphomethylpyrimidine kinase
I1A55_RS05810	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I1A55_RS05865	COG0210	DNA helicase
I1A55_RS05875	COG2153	protein acetylation
I1A55_RS05880	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I1A55_RS05885	COG2382	esterase
I1A55_RS05890	COG0626	cystathionine gamma-synthase activity
I1A55_RS05895	COG0626	cystathionine gamma-synthase activity
I1A55_RS05925	COG0825	malonyl-CoA metabolic process
I1A55_RS05940	COG0457	Tetratricopeptide repeat
I1A55_RS05950	COG2153	protein acetylation
I1A55_RS05955	COG2364	Membrane
I1A55_RS05990	COG3173	Aminoglycoside phosphotransferase
I1A55_RS05995	COG0583	DNA-binding transcription factor activity
I1A55_RS06015	COG0583	DNA-binding transcription factor activity
I1A55_RS06020	COG2807	transmembrane transport
I1A55_RS06055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I1A55_RS06065	COG1309	transcriptional regulator
I1A55_RS06075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I1A55_RS06080	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I1A55_RS06085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I1A55_RS06090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I1A55_RS06110	COG4195	phage-related replication protein
I1A55_RS06115	COG2856	Zn peptidase
I1A55_RS06120	COG5632	N-Acetylmuramoyl-L-alanine amidase
I1A55_RS06120	COG3409	Peptidoglycan-binding domain 1 protein
I1A55_RS06135	COG0306	phosphate transporter
I1A55_RS06140	COG1392	Phosphate transport regulator
I1A55_RS06150	COG0405	Gamma-glutamyltransferase
I1A55_RS06155	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I1A55_RS06165	COG4208	sulfate ABC transporter
I1A55_RS06170	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I1A55_RS06180	COG3775	system Galactitol-specific IIC component
I1A55_RS06195	COG1063	alcohol dehydrogenase
I1A55_RS06200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I1A55_RS06205	COG0022	dehydrogenase e1 component
I1A55_RS06205	COG0508	dehydrogenase complex catalyzes the overall conversion of
I1A55_RS06210	COG0508	dehydrogenase complex catalyzes the overall conversion of
I1A55_RS06215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1A55_RS06220	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS06225	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS06230	COG2390	Transcriptional regulator
I1A55_RS06240	COG0531	amino acid
I1A55_RS06245	COG0346	lactoylglutathione lyase activity
I1A55_RS06250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1A55_RS06255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I1A55_RS06260	COG2362	D-Aminopeptidase
I1A55_RS06265	COG0601	transmembrane transport
I1A55_RS06270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A55_RS06275	COG0444	Belongs to the ABC transporter superfamily
I1A55_RS06280	COG4166	transmembrane transport
I1A55_RS06285	COG1619	proteins homologs of microcin C7 resistance protein MccF
I1A55_RS06290	COG4948	Mandelate Racemase Muconate Lactonizing
I1A55_RS06295	COG0791	NLP P60 protein
I1A55_RS06300	COG4608	Belongs to the ABC transporter superfamily
I1A55_RS06305	COG1834	amidinotransferase
I1A55_RS06310	COG1607	acyl-coa hydrolase
I1A55_RS06315	COG1695	Transcriptional regulator
I1A55_RS06330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I1A55_RS06340	COG2076	Multidrug Resistance protein
I1A55_RS06345	COG2076	Multidrug Resistance protein
I1A55_RS06355	COG0788	formyltetrahydrofolate deformylase activity
I1A55_RS06360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I1A55_RS06365	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I1A55_RS06370	COG0457	Tetratricopeptide repeat
I1A55_RS06380	COG1764	response to oxidative stress
I1A55_RS06385	COG1846	Transcriptional regulator
I1A55_RS06390	COG1764	response to oxidative stress
I1A55_RS06395	COG0590	tRNA wobble adenosine to inosine editing
I1A55_RS06400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I1A55_RS06405	COG1404	Belongs to the peptidase S8 family
I1A55_RS06420	COG0745	RESPONSE REGULATOR receiver
I1A55_RS06425	COG3850	Histidine kinase
I1A55_RS06425	COG5002	protein histidine kinase activity
I1A55_RS06430	COG3212	peptidase
I1A55_RS06435	COG3212	peptidase
I1A55_RS06445	COG2239	Acts as a magnesium transporter
I1A55_RS06455	COG0583	DNA-binding transcription factor activity
I1A55_RS06465	COG0789	Transcriptional regulator
I1A55_RS06480	COG1846	Transcriptional regulator
I1A55_RS06485	COG3300	MHYT domain
I1A55_RS06485	COG5001	Diguanylate cyclase
I1A55_RS06490	COG0586	Pfam SNARE associated Golgi protein
I1A55_RS06495	COG0861	Integral membrane protein TerC family
I1A55_RS06500	COG1191	sigma factor activity
I1A55_RS06520	COG0501	Belongs to the peptidase M48B family
I1A55_RS06525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I1A55_RS06530	COG2323	membrane
I1A55_RS06545	COG3594	Acyltransferase
I1A55_RS06550	COG5002	protein histidine kinase activity
I1A55_RS06555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I1A55_RS06560	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I1A55_RS06565	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
I1A55_RS06570	COG0436	Aminotransferase
I1A55_RS06575	COG1850	ribulose-bisphosphate carboxylase activity
I1A55_RS06580	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
I1A55_RS06585	COG0235	Class ii aldolase
I1A55_RS06590	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I1A55_RS06600	COG3852	Histidine kinase
I1A55_RS06605	COG1846	Transcriptional regulator
I1A55_RS06610	COG1360	Flagellar Motor Protein
I1A55_RS06615	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I1A55_RS06625	COG0542	response to heat
I1A55_RS06630	COG3949	Membrane
I1A55_RS06635	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I1A55_RS06640	COG0720	synthase
I1A55_RS06645	COG0602	queuosine metabolic process
I1A55_RS06650	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I1A55_RS06660	COG4873	Protein conserved in bacteria
I1A55_RS06670	COG3773	Cell wall hydrolase
I1A55_RS06675	COG2244	polysaccharide biosynthetic process
I1A55_RS06680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1A55_RS06685	COG2217	Heavy metal translocating P-type atpase
I1A55_RS06690	COG0006	proline dipeptidase activity
I1A55_RS06695	COG1609	Transcriptional regulator
I1A55_RS06700	COG3711	transcriptional antiterminator
I1A55_RS06705	COG1263	PTS System
I1A55_RS06705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A55_RS06705	COG2190	(PTS) system
I1A55_RS06710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A55_RS06715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I1A55_RS06725	COG1533	DNA photolyase activity
I1A55_RS06730	COG0840	transmembrane signaling receptor activity
I1A55_RS06740	COG2084	Dehydrogenase
I1A55_RS06745	COG2340	Cysteine-rich secretory protein family
I1A55_RS06750	COG0768	penicillin binding
I1A55_RS06755	COG4191	Histidine kinase
I1A55_RS06760	COG0436	Aminotransferase
I1A55_RS06765	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I1A55_RS06775	COG1714	RDD family
I1A55_RS06785	COG0784	Response regulator, receiver
I1A55_RS06785	COG0835	chemotaxis
I1A55_RS06795	COG2207	Transcriptional regulator
I1A55_RS06795	COG1917	Cupin 2, conserved barrel domain protein
I1A55_RS06800	COG0697	spore germination
I1A55_RS06815	COG2814	Major facilitator Superfamily
I1A55_RS06820	COG1376	ErfK ybiS ycfS ynhG family protein
I1A55_RS06825	COG1408	metallophosphoesterase
I1A55_RS06830	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS06835	COG2200	EAL domain
I1A55_RS06840	COG3546	catalase activity
I1A55_RS06845	COG4703	Protein of unknown function (DUF1797)
I1A55_RS06850	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I1A55_RS06860	COG0517	IMP dehydrogenase activity
I1A55_RS06865	COG0583	DNA-binding transcription factor activity
I1A55_RS06875	COG0716	FMN binding
I1A55_RS06885	COG0716	FMN binding
I1A55_RS06890	COG2171	N-acyltransferase activity
I1A55_RS06895	COG1473	amidohydrolase
I1A55_RS06905	COG0668	transmembrane transport
I1A55_RS06910	COG0450	alkyl hydroperoxide reductase
I1A55_RS06915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1A55_RS06930	COG0746	molybdenum cofactor guanylyltransferase activity
I1A55_RS06935	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I1A55_RS06940	COG0303	'Molybdopterin
I1A55_RS06945	COG1763	Mo-molybdopterin cofactor biosynthetic process
I1A55_RS06950	COG0314	molybdopterin synthase activity
I1A55_RS06955	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I1A55_RS06970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I1A55_RS06975	COG1136	(ABC) transporter
I1A55_RS06980	COG0577	efflux transmembrane transporter activity
I1A55_RS06985	COG1349	DNA-binding transcription factor activity
I1A55_RS06990	COG1105	Belongs to the carbohydrate kinase PfkB family
I1A55_RS06995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A55_RS06995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I1A55_RS06995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I1A55_RS07000	COG0681	Belongs to the peptidase S26 family
I1A55_RS07010	COG0488	(ABC) transporter
I1A55_RS07020	COG2309	aminopeptidase activity
I1A55_RS07030	COG1077	Cell shape determining protein MreB Mrl
I1A55_RS07035	COG2002	toxin-antitoxin pair type II binding
I1A55_RS07040	COG3852	Histidine kinase
I1A55_RS07045	COG2105	PFAM AIG2 family protein
I1A55_RS07045	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I1A55_RS07050	COG0569	domain protein
I1A55_RS07055	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I1A55_RS07060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I1A55_RS07065	COG5503	Protein of unknown function (DUF1447)
I1A55_RS07070	COG0561	phosphatase activity
I1A55_RS07075	COG0242	peptide deformylase activity
I1A55_RS07090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I1A55_RS07095	COG0022	dehydrogenase e1 component
I1A55_RS07100	COG0508	dehydrogenase complex catalyzes the overall conversion of
I1A55_RS07105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1A55_RS07110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1A55_RS07120	COG1982	Orn Lys Arg decarboxylase major
I1A55_RS07125	COG4476	Belongs to the UPF0223 family
I1A55_RS07130	COG4493	Belongs to the UPF0637 family
I1A55_RS07140	COG0483	inositol monophosphate 1-phosphatase activity
I1A55_RS07155	COG1595	DNA-templated transcription, initiation
I1A55_RS07175	COG1217	gtp-binding protein TYPA
I1A55_RS07185	COG4896	Protein conserved in bacteria
I1A55_RS07195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I1A55_RS07200	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I1A55_RS07205	COG2066	Belongs to the glutaminase family
I1A55_RS07210	COG4838	Belongs to the UPF0358 family
I1A55_RS07215	COG0772	Belongs to the SEDS family
I1A55_RS07220	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I1A55_RS07225	COG0415	Belongs to the DNA photolyase family
I1A55_RS07230	COG1612	heme a metabolic process
I1A55_RS07235	COG0109	protoheme IX farnesyltransferase activity
I1A55_RS07240	COG2010	Cytochrome c
I1A55_RS07240	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I1A55_RS07245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I1A55_RS07250	COG1845	cytochrome c oxidase, subunit III
I1A55_RS07255	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I1A55_RS07260	COG3336	cytochrome c oxidase
I1A55_RS07270	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I1A55_RS07275	COG2340	Cysteine-rich secretory protein family
I1A55_RS07295	COG3679	Belongs to the UPF0342 family
I1A55_RS07300	COG4471	UPF0298 protein
I1A55_RS07305	COG0742	ribosomal rna small subunit methyltransferase
I1A55_RS07310	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I1A55_RS07315	COG3314	Sporulation integral membrane protein YlbJ
I1A55_RS07320	COG1752	Esterase of the alpha-beta hydrolase superfamily
I1A55_RS07325	COG3480	Lon protease (S16) C-terminal proteolytic domain
I1A55_RS07335	COG1399	metal-binding, possibly nucleic acid-binding protein
I1A55_RS07340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I1A55_RS07350	COG0454	-acetyltransferase
I1A55_RS07355	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I1A55_RS07360	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I1A55_RS07365	COG2001	Belongs to the MraZ family
I1A55_RS07370	COG0275	rRNA processing
I1A55_RS07375	COG4839	cell division protein FtsL
I1A55_RS07380	COG0768	penicillin binding
I1A55_RS07385	COG0768	penicillin binding
I1A55_RS07390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I1A55_RS07395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I1A55_RS07400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I1A55_RS07405	COG0772	Belongs to the SEDS family
I1A55_RS07410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I1A55_RS07415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I1A55_RS07420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I1A55_RS07425	COG3879	Bacterial protein of unknown function (DUF881)
I1A55_RS07430	COG3879	Bacterial protein of unknown function (DUF881)
I1A55_RS07435	COG3856	small basic protein
I1A55_RS07440	COG0849	cell division
I1A55_RS07445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I1A55_RS07450	COG1404	Belongs to the peptidase S8 family
I1A55_RS07450	COG4412	M6 family metalloprotease domain protein
I1A55_RS07460	COG1191	sigma factor activity
I1A55_RS07465	COG1191	sigma factor activity
I1A55_RS07470	COG2390	Transcriptional regulator
I1A55_RS07485	COG3730	PTS system glucitol sorbitol-specific
I1A55_RS07490	COG3732	PTS system glucitol sorbitol-specific
I1A55_RS07500	COG1119	ATPase activity
I1A55_RS07505	COG1873	PFAM PRC-barrel domain
I1A55_RS07510	COG1496	oxidoreductase activity
I1A55_RS07515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I1A55_RS07520	COG1799	cell septum assembly
I1A55_RS07525	COG0762	integral membrane protein
I1A55_RS07530	COG2302	S4 RNA-binding domain
I1A55_RS07535	COG3599	regulation of cell shape
I1A55_RS07540	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I1A55_RS07545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I1A55_RS07550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I1A55_RS07555	COG0564	pseudouridine synthase activity
I1A55_RS07560	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I1A55_RS07565	COG2233	PERMEase
I1A55_RS07570	COG0540	Belongs to the ATCase OTCase family
I1A55_RS07575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I1A55_RS07580	COG0505	Belongs to the CarA family
I1A55_RS07585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I1A55_RS07590	COG0543	2 iron, 2 sulfur cluster binding
I1A55_RS07595	COG0167	dihydroorotate dehydrogenase activity
I1A55_RS07600	COG0284	orotidine-5'-phosphate decarboxylase activity
I1A55_RS07605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I1A55_RS07615	COG0175	sulfate reduction
I1A55_RS07620	COG0306	phosphate transporter
I1A55_RS07625	COG2046	Belongs to the sulfate adenylyltransferase family
I1A55_RS07630	COG0529	Catalyzes the synthesis of activated sulfate
I1A55_RS07635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I1A55_RS07640	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
I1A55_RS07645	COG1648	precorrin-2 dehydrogenase activity
I1A55_RS07655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1A55_RS07660	COG1561	YicC-like family, N-terminal region
I1A55_RS07665	COG2052	Domain of unknown function (DUF370)
I1A55_RS07670	COG0194	GDP metabolic process
I1A55_RS07675	COG1758	RNA polymerase activity
I1A55_RS07680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I1A55_RS07685	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I1A55_RS07690	COG0242	peptide deformylase activity
I1A55_RS07695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I1A55_RS07700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I1A55_RS07700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I1A55_RS07705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I1A55_RS07710	COG0631	protein serine/threonine phosphatase activity
I1A55_RS07715	COG0515	serine threonine protein kinase
I1A55_RS07715	COG2815	serine threonine protein kinase
I1A55_RS07720	COG1162	GTPase activity
I1A55_RS07725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I1A55_RS07730	COG1564	THIamine pyrophosphokinase
I1A55_RS07740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I1A55_RS07745	COG1302	Protein conserved in bacteria
I1A55_RS07750	COG1461	Dihydroxyacetone kinase
I1A55_RS07755	COG1760	l-serine dehydratase
I1A55_RS07760	COG1760	l-serine dehydratase
I1A55_RS07765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I1A55_RS07770	COG1349	DNA-binding transcription factor activity
I1A55_RS07775	COG0416	fatty acid biosynthetic process
I1A55_RS07780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I1A55_RS07785	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS07790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1A55_RS07800	COG1196	nuclear chromosome segregation
I1A55_RS07805	COG0552	protein localization to endoplasmic reticulum
I1A55_RS07810	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I1A55_RS07815	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I1A55_RS07820	COG0228	four-way junction DNA binding
I1A55_RS07825	COG1837	Belongs to the UPF0109 family
I1A55_RS07835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I1A55_RS07840	COG0336	Belongs to the RNA methyltransferase TrmD family
I1A55_RS07845	COG0335	large ribosomal subunit rRNA binding
I1A55_RS07850	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I1A55_RS07855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I1A55_RS07865	COG2257	FlhB HrpN YscU SpaS Family
I1A55_RS07870	COG0045	succinate-CoA ligase (ADP-forming) activity
I1A55_RS07875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I1A55_RS07880	COG0758	DNA mediated transformation
I1A55_RS07885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I1A55_RS07890	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I1A55_RS07895	COG4974	Belongs to the 'phage' integrase family
I1A55_RS07900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I1A55_RS07905	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I1A55_RS07910	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I1A55_RS07915	COG1815	bacterial-type flagellum-dependent cell motility
I1A55_RS07920	COG1558	bacterial-type flagellum-dependent cell motility
I1A55_RS07925	COG1677	Flagellar hook-basal body complex protein FliE
I1A55_RS07930	COG1766	The M ring may be actively involved in energy transduction
I1A55_RS07935	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I1A55_RS07940	COG1317	bacterial-type flagellum organization
I1A55_RS07945	COG1157	protein secretion by the type III secretion system
I1A55_RS07950	COG2882	bacterial-type flagellum organization
I1A55_RS07955	COG3334	PFAM MgtE intracellular
I1A55_RS07960	COG3144	bacterial-type flagellum assembly
I1A55_RS07965	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I1A55_RS07970	COG4786	Flagellar basal body rod
I1A55_RS07975	COG1582	Flagellar protein (FlbD)
I1A55_RS07980	COG1580	Controls the rotational direction of flagella during chemotaxis
I1A55_RS07985	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I1A55_RS07990	COG1776	CheC inhibitor of MCP methylation
I1A55_RS07990	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I1A55_RS07995	COG2201	protein-glutamate methylesterase activity
I1A55_RS08000	COG3190	flagellar
I1A55_RS08005	COG1338	Plays a role in the flagellum-specific transport system
I1A55_RS08010	COG1987	bacterial-type flagellum assembly
I1A55_RS08015	COG1684	flagellar biosynthetic protein fliR
I1A55_RS08020	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I1A55_RS08025	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I1A55_RS08030	COG1419	protein localization to endoplasmic reticulum
I1A55_RS08035	COG0455	bacterial-type flagellum organization
I1A55_RS08040	COG2201	protein-glutamate methylesterase activity
I1A55_RS08045	COG2198	Histidine kinase
I1A55_RS08045	COG0643	Histidine kinase
I1A55_RS08050	COG0835	chemotaxis
I1A55_RS08055	COG1776	CheC inhibitor of MCP methylation
I1A55_RS08065	COG1191	sigma factor activity
I1A55_RS08080	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I1A55_RS08085	COG0528	UMP kinase activity
I1A55_RS08090	COG0233	cytoplasmic translational termination
I1A55_RS08095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I1A55_RS08100	COG4589	Belongs to the CDS family
I1A55_RS08105	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I1A55_RS08110	COG0750	zinc metalloprotease
I1A55_RS08115	COG0442	prolyl-tRNA aminoacylation
I1A55_RS08120	COG2176	DNA-directed DNA polymerase activity
I1A55_RS08135	COG3693	PFAM glycoside hydrolase, family 10
I1A55_RS08145	COG0779	Required for maturation of 30S ribosomal subunits
I1A55_RS08150	COG0195	Participates in both transcription termination and antitermination
I1A55_RS08155	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I1A55_RS08160	COG1358	cellular component organization or biogenesis
I1A55_RS08165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I1A55_RS08170	COG1550	Protein conserved in bacteria
I1A55_RS08175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I1A55_RS08180	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I1A55_RS08185	COG0196	riboflavin kinase activity
I1A55_RS08190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I1A55_RS08195	COG1185	polyribonucleotide nucleotidyltransferase activity
I1A55_RS08200	COG0726	polysaccharide deacetylase
I1A55_RS08205	COG0612	Peptidase, M16
I1A55_RS08215	COG1873	PFAM PRC-barrel domain
I1A55_RS08220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I1A55_RS08225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I1A55_RS08230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I1A55_RS08235	COG0527	aspartate kinase activity
I1A55_RS08245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I1A55_RS08250	COG0740	serine-type endopeptidase activity
I1A55_RS08260	COG1674	ftsk spoiiie
I1A55_RS08260	COG4980	gas vesicle protein
I1A55_RS08265	COG2188	Transcriptional regulator
I1A55_RS08270	COG2814	Major facilitator Superfamily
I1A55_RS08275	COG1033	growth of symbiont in host cell
I1A55_RS08275	COG2409	Drug exporters of the RND superfamily
I1A55_RS08280	COG0612	Peptidase, M16
I1A55_RS08285	COG0612	Peptidase, M16
I1A55_RS08295	COG1033	growth of symbiont in host cell
I1A55_RS08295	COG2409	Drug exporters of the RND superfamily
I1A55_RS08300	COG0300	oxidoreductase activity
I1A55_RS08315	COG1426	Protein conserved in bacteria
I1A55_RS08320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I1A55_RS08325	COG1546	Belongs to the CinA family
I1A55_RS08325	COG1058	Belongs to the CinA family
I1A55_RS08330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I1A55_RS08335	COG1418	mRNA catabolic process
I1A55_RS08340	COG1692	metallophosphoesterase
I1A55_RS08345	COG2359	stage V sporulation protein S
I1A55_RS08350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I1A55_RS08355	COG1063	alcohol dehydrogenase
I1A55_RS08360	COG0156	8-amino-7-oxononanoate synthase activity
I1A55_RS08365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I1A55_RS08370	COG4550	Control of competence regulator ComK, YlbF/YmcA
I1A55_RS08380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I1A55_RS08385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I1A55_RS08400	COG1329	Transcriptional regulator
I1A55_RS08405	COG4195	phage-related replication protein
I1A55_RS08410	COG0457	Tetratricopeptide repeat
I1A55_RS08415	COG1404	Belongs to the peptidase S8 family
I1A55_RS08420	COG4195	phage-related replication protein
I1A55_RS08425	COG1764	response to oxidative stress
I1A55_RS08430	COG2076	Multidrug Resistance protein
I1A55_RS08455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I1A55_RS08460	COG1923	regulation of RNA biosynthetic process
I1A55_RS08475	COG1780	Probably involved in ribonucleotide reductase function
I1A55_RS08480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I1A55_RS08485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I1A55_RS08490	COG4112	unkown
I1A55_RS08500	COG0464	growth
I1A55_RS08505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I1A55_RS08510	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I1A55_RS08515	COG0789	Transcriptional regulator
I1A55_RS08520	COG0174	glutamine synthetase
I1A55_RS08540	COG0457	Tetratricopeptide repeat
I1A55_RS08560	COG5444	nuclease activity
I1A55_RS08585	COG5646	InterPro IPR014922
I1A55_RS08605	COG0457	Tetratricopeptide repeat
I1A55_RS08615	COG3619	membrane
I1A55_RS08620	COG1793	dna ligase
I1A55_RS08620	COG3285	dna ligase
I1A55_RS08625	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I1A55_RS08630	COG4876	unkown
I1A55_RS08640	COG1959	2 iron, 2 sulfur cluster binding
I1A55_RS08645	COG0702	epimerase
I1A55_RS08655	COG0247	lactate metabolic process
I1A55_RS08660	COG1139	Iron-sulfur cluster binding protein
I1A55_RS08665	COG1556	Lactate utilization protein
I1A55_RS08685	COG2323	membrane
I1A55_RS08690	COG1309	transcriptional regulator
I1A55_RS08695	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I1A55_RS08695	COG2124	cytochrome p450
I1A55_RS08700	COG3591	Belongs to the peptidase S1B family
I1A55_RS08705	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I1A55_RS08710	COG3209	COG3209 Rhs family protein
I1A55_RS08715	COG1366	Belongs to the anti-sigma-factor antagonist family
I1A55_RS08730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I1A55_RS08735	COG1388	LysM domain
I1A55_RS08740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I1A55_RS08745	COG4224	UPF0291 protein
I1A55_RS08750	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I1A55_RS08760	COG3763	UPF0154 protein
I1A55_RS08770	COG0785	Cytochrome C biogenesis protein
I1A55_RS08775	COG4846	Membrane protein involved in cytochrome C biogenesis
I1A55_RS08785	COG0071	Belongs to the small heat shock protein (HSP20) family
I1A55_RS08800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I1A55_RS08805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1A55_RS08825	COG0824	Thioesterase
I1A55_RS08835	COG4841	protein insertion into membrane
I1A55_RS08840	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I1A55_RS08845	COG1832	CoA-binding protein
I1A55_RS08850	COG0187	DNA topoisomerase II activity
I1A55_RS08855	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I1A55_RS08865	COG0738	Major facilitator superfamily
I1A55_RS08870	COG0473	3-isopropylmalate dehydrogenase activity
I1A55_RS08880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I1A55_RS08885	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I1A55_RS08890	COG0640	Transcriptional regulator
I1A55_RS08900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I1A55_RS08905	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I1A55_RS08915	COG1309	transcriptional regulator
I1A55_RS08920	COG2249	NAD(P)H dehydrogenase (quinone) activity
I1A55_RS08925	COG1733	regulation of RNA biosynthetic process
I1A55_RS08930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I1A55_RS08935	COG0251	oxidation-reduction process
I1A55_RS08975	COG0657	acetylesterase activity
I1A55_RS08985	COG2723	6-phospho-beta-galactosidase activity
I1A55_RS08990	COG1263	PTS System
I1A55_RS08990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A55_RS08990	COG2190	(PTS) system
I1A55_RS09005	COG2205	protein histidine kinase activity
I1A55_RS09010	COG0745	RESPONSE REGULATOR receiver
I1A55_RS09020	COG3507	Belongs to the glycosyl hydrolase 43 family
I1A55_RS09025	COG1012	belongs to the aldehyde dehydrogenase family
I1A55_RS09030	COG1486	melibiose metabolic process
I1A55_RS09035	COG0395	ABC-type sugar transport system, permease component
I1A55_RS09040	COG1175	transmembrane transport
I1A55_RS09045	COG1653	transport
I1A55_RS09050	COG1609	Transcriptional regulator
I1A55_RS09055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I1A55_RS09070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A55_RS09095	COG0456	acetyltransferase
I1A55_RS09100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I1A55_RS09115	COG5444	nuclease activity
I1A55_RS09125	COG1846	Transcriptional regulator
I1A55_RS09130	COG2814	Major facilitator Superfamily
I1A55_RS09140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A55_RS09140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I1A55_RS09140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I1A55_RS09145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I1A55_RS09145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I1A55_RS09145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A55_RS09150	COG1105	Belongs to the carbohydrate kinase PfkB family
I1A55_RS09160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I1A55_RS09185	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I1A55_RS09190	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I1A55_RS09195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1A55_RS09200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I1A55_RS09205	COG1024	Enoyl-CoA hydratase
I1A55_RS09210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I1A55_RS09215	COG0511	ligase activity, forming carbon-carbon bonds
I1A55_RS09220	COG0439	Biotin carboxylase
I1A55_RS09225	COG0318	PFAM AMP-dependent synthetase and ligase
I1A55_RS09230	COG1960	acyl-CoA dehydrogenase activity
I1A55_RS09235	COG1649	PFAM Uncharacterised BCR, COG1649
I1A55_RS09240	COG2365	Tyrosine phosphatase family
I1A55_RS09245	COG1349	DNA-binding transcription factor activity
I1A55_RS09250	COG1942	4-Oxalocrotonate Tautomerase
I1A55_RS09260	COG3835	regulator
I1A55_RS09265	COG0277	FAD linked oxidase domain protein
I1A55_RS09270	COG0247	lactate metabolic process
I1A55_RS09290	COG0166	Belongs to the GPI family
I1A55_RS09295	COG2246	polysaccharide biosynthetic process
I1A55_RS09300	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I1A55_RS09305	COG0586	Pfam SNARE associated Golgi protein
I1A55_RS09310	COG1587	Uroporphyrinogen-III synthase
I1A55_RS09320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A55_RS09360	COG0534	Mate efflux family protein
I1A55_RS09365	COG2027	D-alanyl-D-alanine carboxypeptidase
I1A55_RS09370	COG4677	pectinesterase activity
I1A55_RS09375	COG2323	membrane
I1A55_RS09380	COG2146	nitrite reductase [NAD(P)H] activity
I1A55_RS09385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I1A55_RS09390	COG0243	molybdopterin cofactor binding
I1A55_RS09395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I1A55_RS09400	COG2223	nitrite transmembrane transporter activity
I1A55_RS09405	COG0493	'glutamate synthase
I1A55_RS09410	COG0069	glutamate synthase activity
I1A55_RS09410	COG0067	glutamate synthase
I1A55_RS09410	COG0070	glutamate synthase
I1A55_RS09415	COG0583	DNA-binding transcription factor activity
I1A55_RS09425	COG1132	(ABC) transporter
I1A55_RS09430	COG4978	Transcriptional regulator
I1A55_RS09430	COG0789	Transcriptional regulator
I1A55_RS09435	COG0454	-acetyltransferase
I1A55_RS09440	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I1A55_RS09445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I1A55_RS09450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I1A55_RS09460	COG0243	molybdopterin cofactor binding
I1A55_RS09470	COG1070	Carbohydrate kinase
I1A55_RS09475	COG2115	Belongs to the xylose isomerase family
I1A55_RS09480	COG1940	carbohydrate kinase activity
I1A55_RS09490	COG2211	Major facilitator Superfamily
I1A55_RS09495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I1A55_RS09500	COG1994	Peptidase M50
I1A55_RS09520	COG1309	transcriptional regulator
I1A55_RS09525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I1A55_RS09530	COG3708	Transcriptional regulator
I1A55_RS09535	COG2378	regulation of single-species biofilm formation
I1A55_RS09545	COG0640	Transcriptional regulator
I1A55_RS09550	COG0531	amino acid
I1A55_RS09555	COG0741	lytic transglycosylase activity
I1A55_RS09560	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I1A55_RS09565	COG2079	MmgE PrpD family protein
I1A55_RS09570	COG0372	Belongs to the citrate synthase family
I1A55_RS09575	COG2322	membrane
I1A55_RS09585	COG1388	LysM domain
I1A55_RS09585	COG3584	3D domain protein
I1A55_RS09590	COG0514	ATP-dependent DNA helicase (RecQ)
I1A55_RS09600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I1A55_RS09625	COG1012	belongs to the aldehyde dehydrogenase family
I1A55_RS09630	COG1657	PFAM Prenyltransferase squalene oxidase
I1A55_RS09635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I1A55_RS09640	COG0385	Bile acid
I1A55_RS09645	COG0508	dehydrogenase complex catalyzes the overall conversion of
I1A55_RS09650	COG0567	Dehydrogenase, E1 component
I1A55_RS09655	COG4548	von Willebrand factor, type A
I1A55_RS09660	COG0714	Associated with various cellular activities
I1A55_RS09665	COG2032	superoxide dismutase activity
I1A55_RS09670	COG1388	LysM domain
I1A55_RS09670	COG0791	NLP P60 protein
I1A55_RS09675	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I1A55_RS09680	COG0534	Mate efflux family protein
I1A55_RS09685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I1A55_RS09690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I1A55_RS09700	COG2962	Rard protein
I1A55_RS09715	COG1733	regulation of RNA biosynthetic process
I1A55_RS09720	COG0778	Nitroreductase
I1A55_RS09730	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I1A55_RS09735	COG3409	Peptidoglycan-binding domain 1 protein
I1A55_RS09735	COG0793	Belongs to the peptidase S41A family
I1A55_RS09740	COG2226	methyltransferase
I1A55_RS09755	COG1876	peptidase activity
I1A55_RS09760	COG0813	purine-nucleoside phosphorylase activity
I1A55_RS09770	COG0671	phosphoesterase, PA-phosphatase related
I1A55_RS09790	COG4479	Belongs to the UPF0346 family
I1A55_RS09800	COG1509	lysine 2,3-aminomutase activity
I1A55_RS09805	COG3829	transcription factor binding
I1A55_RS09810	COG0463	Glycosyl transferase, family 2
I1A55_RS09825	COG4641	Protein conserved in bacteria
I1A55_RS09835	COG1086	Polysaccharide biosynthesis protein
I1A55_RS09840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I1A55_RS09845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I1A55_RS09850	COG1846	Transcriptional regulator
I1A55_RS09870	COG4698	Protein conserved in bacteria
I1A55_RS09875	COG2755	lipolytic protein G-D-S-L family
I1A55_RS09880	COG1999	signal sequence binding
I1A55_RS09895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I1A55_RS09900	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I1A55_RS09905	COG1272	protein, Hemolysin III
I1A55_RS09910	COG0204	Acyl-transferase
I1A55_RS09915	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I1A55_RS09920	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I1A55_RS09925	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I1A55_RS09935	COG2521	methyltransferase
I1A55_RS09935	COG2136	Putative SAM-dependent methyltransferase
I1A55_RS09945	COG0129	dihydroxy-acid dehydratase activity
I1A55_RS09950	COG1413	lyase activity
I1A55_RS09955	COG1418	mRNA catabolic process
I1A55_RS09960	COG0386	Belongs to the glutathione peroxidase family
I1A55_RS09965	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I1A55_RS09970	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I1A55_RS09975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I1A55_RS09985	COG1278	Cold shock
I1A55_RS10000	COG0328	RNA-DNA hybrid ribonuclease activity
I1A55_RS10005	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I1A55_RS10010	COG0328	RNA-DNA hybrid ribonuclease activity
I1A55_RS10020	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1A55_RS10030	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I1A55_RS10040	COG1755	Isoprenylcysteine carboxyl methyltransferase
I1A55_RS10045	COG3424	synthase
I1A55_RS10050	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I1A55_RS10050	COG0456	acetyltransferase
I1A55_RS10055	COG0726	polysaccharide deacetylase
I1A55_RS10060	COG2233	PERMEase
I1A55_RS10065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I1A55_RS10070	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I1A55_RS10075	COG1199	ATP-dependent helicase activity
I1A55_RS10085	COG0116	Belongs to the methyltransferase superfamily
I1A55_RS10095	COG3599	regulation of cell shape
I1A55_RS10100	COG4474	Belongs to the UPF0398 family
I1A55_RS10110	COG3359	exonuclease
I1A55_RS10115	COG1111	helicase
I1A55_RS10115	COG1205	dead DEAH box helicase
I1A55_RS10120	COG1902	pentaerythritol trinitrate reductase activity
I1A55_RS10125	COG2190	(PTS) system
I1A55_RS10130	COG0071	Belongs to the small heat shock protein (HSP20) family
I1A55_RS10160	COG3331	DNA recombination
I1A55_RS10165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1A55_RS10165	COG4499	WXG100 protein secretion system (Wss), protein YukC
I1A55_RS10175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I1A55_RS10180	COG3935	DnaD domain protein
I1A55_RS10185	COG0017	Asparaginyl-tRNA synthetase
I1A55_RS10190	COG5353	protein conserved in bacteria
I1A55_RS10200	COG1199	ATP-dependent helicase activity
I1A55_RS10200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I1A55_RS10205	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I1A55_RS10210	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I1A55_RS10215	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I1A55_RS10225	COG0617	tRNA 3'-terminal CCA addition
I1A55_RS10230	COG0438	transferase activity, transferring glycosyl groups
I1A55_RS10235	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I1A55_RS10240	COG1803	Methylglyoxal synthase
I1A55_RS10245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I1A55_RS10250	COG1694	Mazg nucleotide pyrophosphohydrolase
I1A55_RS10255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I1A55_RS10265	COG4347	Protein of unknown function (DUF1405)
I1A55_RS10270	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I1A55_RS10270	COG2010	Cytochrome c
I1A55_RS10275	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I1A55_RS10280	COG0723	plastoquinol--plastocyanin reductase activity
I1A55_RS10290	COG5582	Belongs to the UPF0302 family
I1A55_RS10295	COG0457	Tetratricopeptide repeat
I1A55_RS10300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I1A55_RS10305	COG0287	Prephenate dehydrogenase
I1A55_RS10310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I1A55_RS10315	COG0159	tryptophan synthase activity
I1A55_RS10320	COG0133	tryptophan synthase activity
I1A55_RS10325	COG0135	phosphoribosylanthranilate isomerase activity
I1A55_RS10330	COG0134	indole-3-glycerol-phosphate synthase activity
I1A55_RS10335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I1A55_RS10345	COG4401	Chorismate mutase type I
I1A55_RS10350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I1A55_RS10355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I1A55_RS10360	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I1A55_RS10365	COG0105	UTP biosynthetic process
I1A55_RS10370	COG0142	geranyltranstransferase activity
I1A55_RS10375	COG2226	methyltransferase
I1A55_RS10380	COG0142	geranyltranstransferase activity
I1A55_RS10390	COG0302	gtp cyclohydrolase
I1A55_RS10395	COG0776	regulation of translation
I1A55_RS10400	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I1A55_RS10415	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I1A55_RS10420	COG1160	GTP binding
I1A55_RS10445	COG1304	FMN binding
I1A55_RS10450	COG0539	negative regulation of cytoplasmic translation
I1A55_RS10455	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I1A55_RS10465	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I1A55_RS10470	COG2959	enzyme of heme biosynthesis
I1A55_RS10475	COG3409	Peptidoglycan-binding domain 1 protein
I1A55_RS10475	COG3773	Cell wall hydrolase
I1A55_RS10480	COG2339	peptidase activity
I1A55_RS10485	COG0492	ferredoxin-NADP+ reductase activity
I1A55_RS10490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I1A55_RS10495	COG4862	establishment of competence for transformation
I1A55_RS10500	COG1408	metallophosphoesterase
I1A55_RS10510	COG1388	LysM domain
I1A55_RS10515	COG1266	CAAX protease self-immunity
I1A55_RS10520	COG0514	ATP-dependent DNA helicase (RecQ)
I1A55_RS10525	COG4955	Helix-turn-helix domain
I1A55_RS10530	COG1141	Ferredoxin
I1A55_RS10535	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I1A55_RS10540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I1A55_RS10555	COG1595	DNA-templated transcription, initiation
I1A55_RS10560	COG5002	protein histidine kinase activity
I1A55_RS10565	COG0745	RESPONSE REGULATOR receiver
I1A55_RS10570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I1A55_RS10575	COG1333	cytochrome c biogenesis protein
I1A55_RS10580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1A55_RS10585	COG1187	pseudouridine synthase activity
I1A55_RS10590	COG0700	Nucleoside recognition
I1A55_RS10595	COG2715	membrane protein required for spore maturation
I1A55_RS10600	COG1686	Belongs to the peptidase S11 family
I1A55_RS10610	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I1A55_RS10615	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I1A55_RS10625	COG1547	Domain of unknown function (DUF309)
I1A55_RS10630	COG0456	acetyltransferase
I1A55_RS10635	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I1A55_RS10640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I1A55_RS10640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I1A55_RS10645	COG0307	riboflavin synthase, alpha
I1A55_RS10665	COG2814	Major facilitator Superfamily
I1A55_RS10670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I1A55_RS10675	COG4086	secreted protein
I1A55_RS10680	COG0019	diaminopimelate decarboxylase activity
I1A55_RS10685	COG0697	spore germination
I1A55_RS10700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I1A55_RS10720	COG1191	sigma factor activity
I1A55_RS10725	COG2172	sigma factor antagonist activity
I1A55_RS10735	COG1686	Belongs to the peptidase S11 family
I1A55_RS10740	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I1A55_RS10745	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I1A55_RS10750	COG4974	Belongs to the 'phage' integrase family
I1A55_RS10760	COG0735	belongs to the Fur family
I1A55_RS10765	COG1300	Membrane
I1A55_RS10770	COG1404	Belongs to the peptidase S8 family
I1A55_RS10780	COG2153	protein acetylation
I1A55_RS10785	COG1379	DNA repair
I1A55_RS10790	COG0494	nUDIX hydrolase
I1A55_RS10795	COG0667	Aldo Keto reductase
I1A55_RS10805	COG1073	alpha beta
I1A55_RS10810	COG0457	Tetratricopeptide repeat
I1A55_RS10820	COG4918	Iron-sulphur cluster biosynthesis
I1A55_RS10825	COG4305	rare lipoprotein A
I1A55_RS10830	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I1A55_RS10830	COG0456	acetyltransferase
I1A55_RS10835	COG0456	acetyltransferase
I1A55_RS10845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I1A55_RS10855	COG2211	Major facilitator Superfamily
I1A55_RS10860	COG1072	(Pantothenic acid kinase))
I1A55_RS10865	COG0446	pyridine nucleotide-disulphide oxidoreductase
I1A55_RS10875	COG0300	oxidoreductase activity
I1A55_RS10880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I1A55_RS10885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I1A55_RS10905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I1A55_RS10910	COG4187	Peptidase family M20/M25/M40
I1A55_RS10915	COG1902	pentaerythritol trinitrate reductase activity
I1A55_RS10920	COG0596	Alpha beta hydrolase
I1A55_RS10925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I1A55_RS10935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I1A55_RS10940	COG2188	Transcriptional regulator
I1A55_RS10945	COG2723	6-phospho-beta-galactosidase activity
I1A55_RS10950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I1A55_RS10955	COG1447	Phosphotransferase system cellobiose-specific component IIA
I1A55_RS10960	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I1A55_RS10970	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS10980	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I1A55_RS10985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I1A55_RS10995	COG0706	membrane insertase activity
I1A55_RS11000	COG0835	chemotaxis
I1A55_RS11005	COG2195	Cleaves the N-terminal amino acid of tripeptides
I1A55_RS11010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I1A55_RS11015	COG0346	lactoylglutathione lyase activity
I1A55_RS11025	COG1376	ErfK ybiS ycfS ynhG family protein
I1A55_RS11030	COG4129	membrane
I1A55_RS11035	COG1126	abc transporter atp-binding protein
I1A55_RS11040	COG0765	amino acid transport
I1A55_RS11045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1A55_RS11055	COG1597	lipid kinase activity
I1A55_RS11065	COG0508	dehydrogenase complex catalyzes the overall conversion of
I1A55_RS11070	COG0022	dehydrogenase e1 component
I1A55_RS11075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I1A55_RS11080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1A55_RS11085	COG3426	butyrate kinase activity
I1A55_RS11090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I1A55_RS11095	COG0280	phosphate acetyltransferase
I1A55_RS11100	COG3829	transcription factor binding
I1A55_RS11100	COG3290	protein histidine kinase activity
I1A55_RS11110	COG0584	glycerophosphoryl diester phosphodiesterase
I1A55_RS11115	COG0457	Tetratricopeptide repeat
I1A55_RS11120	COG0745	RESPONSE REGULATOR receiver
I1A55_RS11125	COG0750	zinc metalloprotease
I1A55_RS11130	COG0497	DNA recombination
I1A55_RS11135	COG1438	arginine binding
I1A55_RS11140	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I1A55_RS11145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I1A55_RS11150	COG0142	geranyltranstransferase activity
I1A55_RS11155	COG1722	exodeoxyribonuclease VII activity
I1A55_RS11160	COG1570	exodeoxyribonuclease VII activity
I1A55_RS11165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I1A55_RS11170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I1A55_RS11175	COG1302	Protein conserved in bacteria
I1A55_RS11180	COG0439	Biotin carboxylase
I1A55_RS11185	COG0511	ligase activity, forming carbon-carbon bonds
I1A55_RS11225	COG3854	ATPases associated with a variety of cellular activities
I1A55_RS11235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I1A55_RS11240	COG0006	proline dipeptidase activity
I1A55_RS11245	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I1A55_RS11255	COG3872	metal-dependent enzyme
I1A55_RS11265	COG1752	Esterase of the alpha-beta hydrolase superfamily
I1A55_RS11270	COG1321	iron dependent repressor
I1A55_RS11275	COG0095	Lipoate-protein ligase
I1A55_RS11280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I1A55_RS11285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I1A55_RS11290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I1A55_RS11295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I1A55_RS11300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I1A55_RS11325	COG0681	Belongs to the peptidase S26 family
I1A55_RS11360	COG4970	Tfp pilus assembly protein FimT
I1A55_RS11365	COG4537	Required for transformation and DNA binding
I1A55_RS11370	COG1459	type II secretion system
I1A55_RS11375	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I1A55_RS11380	COG1366	Belongs to the anti-sigma-factor antagonist family
I1A55_RS11390	COG1393	Belongs to the ArsC family
I1A55_RS11400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I1A55_RS11410	COG0011	TIGRFAM Protein of
I1A55_RS11415	COG2814	Major facilitator Superfamily
I1A55_RS11420	COG2866	Carboxypeptidase
I1A55_RS11425	COG1368	sulfuric ester hydrolase activity
I1A55_RS11430	COG1940	carbohydrate kinase activity
I1A55_RS11435	COG4483	Protein conserved in bacteria
I1A55_RS11440	COG0705	Rhomboid family
I1A55_RS11440	COG0457	Tetratricopeptide repeat
I1A55_RS11455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I1A55_RS11460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I1A55_RS11470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I1A55_RS11475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I1A55_RS11480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I1A55_RS11485	COG0581	inorganic phosphate transmembrane transporter activity
I1A55_RS11490	COG0573	inorganic phosphate transmembrane transporter activity
I1A55_RS11495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I1A55_RS11500	COG0768	penicillin binding
I1A55_RS11505	COG0477	Major facilitator Superfamily
I1A55_RS11510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I1A55_RS11515	COG2839	Protein conserved in bacteria
I1A55_RS11520	COG5521	maltodextrose utilization protein MalA
I1A55_RS11525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I1A55_RS11530	COG1388	LysM domain
I1A55_RS11535	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I1A55_RS11540	COG4709	membrane
I1A55_RS11545	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I1A55_RS11550	COG1940	carbohydrate kinase activity
I1A55_RS11555	COG0735	belongs to the Fur family
I1A55_RS11560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I1A55_RS11565	COG1121	(ABC) transporter
I1A55_RS11570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I1A55_RS11585	COG0513	Belongs to the DEAD box helicase family
I1A55_RS11595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I1A55_RS11600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I1A55_RS11605	COG2384	SAM-dependent methyltransferase
I1A55_RS11610	COG2010	Cytochrome c
I1A55_RS11615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1A55_RS11620	COG0358	DNA primase activity
I1A55_RS11625	COG1671	Belongs to the UPF0178 family
I1A55_RS11630	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I1A55_RS11635	COG0517	IMP dehydrogenase activity
I1A55_RS11640	COG0751	glycine-tRNA ligase activity
I1A55_RS11645	COG0752	glycyl-tRNA synthetase alpha subunit
I1A55_RS11650	COG1381	Involved in DNA repair and RecF pathway recombination
I1A55_RS11660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I1A55_RS11665	COG0295	cytidine deaminase activity
I1A55_RS11670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I1A55_RS11675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I1A55_RS11680	COG1480	7TM receptor with intracellular HD hydrolase
I1A55_RS11685	COG1702	phosphate starvation-inducible protein PhoH
I1A55_RS11690	COG0561	phosphatase activity
I1A55_RS11705	COG4864	UPF0365 protein
I1A55_RS11710	COG1030	water channel activity
I1A55_RS11715	COG1610	YqeY-like protein
I1A55_RS11725	COG1283	sodium-dependent phosphate transmembrane transporter activity
I1A55_RS11730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I1A55_RS11735	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I1A55_RS11740	COG2264	protein methyltransferase activity
I1A55_RS11745	COG0484	heat shock protein binding
I1A55_RS11750	COG0443	Heat shock 70 kDa protein
I1A55_RS11755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I1A55_RS11760	COG1420	regulation of RNA biosynthetic process
I1A55_RS11765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I1A55_RS11770	COG0481	GTPase activity
I1A55_RS11780	COG0860	N-Acetylmuramoyl-L-alanine amidase
I1A55_RS11785	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I1A55_RS11790	COG0268	Binds directly to 16S ribosomal RNA
I1A55_RS11795	COG1466	dna polymerase III delta subunit
I1A55_RS11805	COG0658	competence protein
I1A55_RS11805	COG2333	competence protein COMEC
I1A55_RS11810	COG2131	deaminase
I1A55_RS11815	COG1555	photosystem II stabilization
I1A55_RS11815	COG1596	polysaccharide export
I1A55_RS11820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I1A55_RS11825	COG2226	methyltransferase
I1A55_RS11830	COG0799	negative regulation of ribosome biogenesis
I1A55_RS11835	COG1713	HD superfamily hydrolase involved in NAD metabolism
I1A55_RS11840	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I1A55_RS11845	COG1534	Rna-binding protein
I1A55_RS11850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I1A55_RS11855	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I1A55_RS11860	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I1A55_RS11875	COG2755	lipolytic protein G-D-S-L family
I1A55_RS11885	COG0457	Tetratricopeptide repeat
I1A55_RS11915	COG0726	polysaccharide deacetylase
I1A55_RS11950	COG1122	ATPase activity
I1A55_RS11975	COG2160	L-arabinose isomerase activity
I1A55_RS11990	COG1609	Transcriptional regulator
I1A55_RS12000	COG1846	Transcriptional regulator
I1A55_RS12010	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I1A55_RS12015	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I1A55_RS12020	COG1733	regulation of RNA biosynthetic process
I1A55_RS12025	COG0657	acetylesterase activity
I1A55_RS12090	COG2602	Beta-lactamase
I1A55_RS12095	COG1960	acyl-CoA dehydrogenase activity
I1A55_RS12100	COG1126	abc transporter atp-binding protein
I1A55_RS12105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1A55_RS12110	COG0765	amino acid transport
I1A55_RS12120	COG1063	alcohol dehydrogenase
I1A55_RS12130	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS12140	COG1115	amino acid carrier protein
I1A55_RS12145	COG0583	DNA-binding transcription factor activity
I1A55_RS12150	COG1063	alcohol dehydrogenase
I1A55_RS12155	COG2226	methyltransferase
I1A55_RS12180	COG0626	cystathionine gamma-synthase activity
I1A55_RS12185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I1A55_RS12190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I1A55_RS12195	COG2226	methyltransferase
I1A55_RS12210	COG0768	penicillin binding
I1A55_RS12215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I1A55_RS12220	COG0572	uridine kinase
I1A55_RS12225	COG0826	peptidase U32
I1A55_RS12230	COG0826	peptidase U32
I1A55_RS12235	COG4122	O-methyltransferase activity
I1A55_RS12240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I1A55_RS12245	COG0183	Belongs to the thiolase family
I1A55_RS12250	COG0318	PFAM AMP-dependent synthetase and ligase
I1A55_RS12255	COG1268	BioY protein
I1A55_RS12260	COG3906	Belongs to the UPF0473 family
I1A55_RS12265	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I1A55_RS12270	COG4472	Bacterial protein of unknown function (DUF965)
I1A55_RS12275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I1A55_RS12280	COG0628	permease
I1A55_RS12285	COG1126	abc transporter atp-binding protein
I1A55_RS12290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1A55_RS12295	COG0765	amino acid transport
I1A55_RS12300	COG0765	amino acid transport
I1A55_RS12315	COG3881	PFAM PRC-barrel domain
I1A55_RS12320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1A55_RS12325	COG0457	Tetratricopeptide repeat
I1A55_RS12330	COG0482	sulfurtransferase activity
I1A55_RS12335	COG1104	cysteine desulfurase activity
I1A55_RS12340	COG1959	2 iron, 2 sulfur cluster binding
I1A55_RS12345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I1A55_RS12350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I1A55_RS12365	COG0124	histidyl-tRNA synthetase
I1A55_RS12375	COG4991	sh3 domain protein
I1A55_RS12375	COG3103	Sh3 type 3 domain protein
I1A55_RS12375	COG0860	N-Acetylmuramoyl-L-alanine amidase
I1A55_RS12380	COG1490	D-aminoacyl-tRNA deacylase activity
I1A55_RS12385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I1A55_RS12390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I1A55_RS12395	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I1A55_RS12395	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I1A55_RS12400	COG5416	Lipopolysaccharide assembly protein A domain
I1A55_RS12405	COG0490	domain, Protein
I1A55_RS12410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I1A55_RS12410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I1A55_RS12420	COG2244	polysaccharide biosynthetic process
I1A55_RS12425	COG2323	membrane
I1A55_RS12435	COG1862	Preprotein translocase
I1A55_RS12440	COG0343	queuine tRNA-ribosyltransferase activity
I1A55_RS12445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I1A55_RS12455	COG2255	four-way junction helicase activity
I1A55_RS12460	COG0632	four-way junction helicase activity
I1A55_RS12470	COG2112	serine threonine protein kinase
I1A55_RS12485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I1A55_RS12500	COG1388	LysM domain
I1A55_RS12505	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I1A55_RS12510	COG0157	Belongs to the NadC ModD family
I1A55_RS12515	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I1A55_RS12520	COG1104	cysteine desulfurase activity
I1A55_RS12525	COG1827	regulation of RNA biosynthetic process
I1A55_RS12530	COG0077	Prephenate dehydratase
I1A55_RS12535	COG4492	Belongs to the UPF0735 family
I1A55_RS12540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I1A55_RS12545	COG3290	protein histidine kinase activity
I1A55_RS12550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I1A55_RS12555	COG2868	ribosomal protein
I1A55_RS12560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I1A55_RS12565	COG1994	Peptidase M50
I1A55_RS12570	COG0739	heme binding
I1A55_RS12575	COG2894	cell division
I1A55_RS12580	COG0850	regulation of cytokinetic process
I1A55_RS12585	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I1A55_RS12595	COG1077	Cell shape determining protein MreB Mrl
I1A55_RS12600	COG2003	Belongs to the UPF0758 family
I1A55_RS12605	COG0424	maF-like protein
I1A55_RS12615	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I1A55_RS12620	COG0285	dihydrofolate synthase activity
I1A55_RS12625	COG0525	valine-tRNA ligase activity
I1A55_RS12635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I1A55_RS12640	COG1388	LysM domain
I1A55_RS12645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I1A55_RS12650	COG0113	porphobilinogen synthase activity
I1A55_RS12655	COG1587	Uroporphyrinogen-III synthase
I1A55_RS12660	COG0181	hydroxymethylbilane synthase activity
I1A55_RS12665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I1A55_RS12670	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I1A55_RS12695	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I1A55_RS12700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I1A55_RS12705	COG0470	DNA polymerase III
I1A55_RS12705	COG1067	ATP-dependent peptidase activity
I1A55_RS12710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I1A55_RS12715	COG0544	peptidyl-prolyl cis-trans isomerase activity
I1A55_RS12720	COG0457	Tetratricopeptide repeat
I1A55_RS12720	COG1477	protein flavinylation
I1A55_RS12725	COG0066	3-isopropylmalate dehydratase activity
I1A55_RS12730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I1A55_RS12735	COG0473	3-isopropylmalate dehydrogenase activity
I1A55_RS12740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I1A55_RS12745	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I1A55_RS12750	COG0440	acetolactate synthase activity
I1A55_RS12755	COG0028	Belongs to the TPP enzyme family
I1A55_RS12760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I1A55_RS12765	COG2706	6-phosphogluconolactonase activity
I1A55_RS12770	COG3339	Conserved Protein
I1A55_RS12775	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I1A55_RS12780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1A55_RS12785	COG1696	Membrane protein involved in D-alanine export
I1A55_RS12790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A55_RS12825	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I1A55_RS12830	COG5444	nuclease activity
I1A55_RS12845	COG0622	Phosphoesterase
I1A55_RS12850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I1A55_RS12855	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I1A55_RS12860	COG5401	PFAM Sporulation and spore germination
I1A55_RS12865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I1A55_RS12870	COG1846	Transcriptional regulator
I1A55_RS12875	COG2197	response regulator
I1A55_RS12880	COG2851	Citrate transporter
I1A55_RS12885	COG0583	DNA-binding transcription factor activity
I1A55_RS12890	COG2828	Protein conserved in bacteria
I1A55_RS12900	COG0824	Thioesterase
I1A55_RS12905	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I1A55_RS12910	COG1053	succinate dehydrogenase
I1A55_RS12915	COG2009	succinate dehydrogenase
I1A55_RS12920	COG1719	4-vinyl reductase, 4VR
I1A55_RS12925	COG0527	aspartate kinase activity
I1A55_RS12930	COG0322	excinuclease ABC activity
I1A55_RS12935	COG3118	belongs to the thioredoxin family
I1A55_RS12940	COG3534	alpha-L-arabinofuranosidase
I1A55_RS12945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I1A55_RS12950	COG2086	electron transfer activity
I1A55_RS12955	COG1024	Enoyl-CoA hydratase
I1A55_RS12960	COG1309	transcriptional regulator
I1A55_RS12965	COG0318	PFAM AMP-dependent synthetase and ligase
I1A55_RS12975	COG3766	membrane
I1A55_RS12980	COG1193	negative regulation of DNA recombination
I1A55_RS12985	COG1796	DNA polymerase
I1A55_RS12985	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I1A55_RS12990	COG1286	toxin biosynthetic process
I1A55_RS12995	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I1A55_RS13000	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I1A55_RS13005	COG0072	phenylalanine-tRNA ligase activity
I1A55_RS13005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I1A55_RS13010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I1A55_RS13015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I1A55_RS13025	COG1966	Carbon starvation protein
I1A55_RS13030	COG1363	Peptidase, m42
I1A55_RS13040	COG3326	Membrane
I1A55_RS13045	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I1A55_RS13050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I1A55_RS13055	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I1A55_RS13065	COG1011	Hydrolase
I1A55_RS13075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I1A55_RS13085	COG0398	Pfam SNARE associated Golgi protein
I1A55_RS13090	COG1484	DNA-dependent DNA replication
I1A55_RS13095	COG3611	Membrane attachment protein
I1A55_RS13100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I1A55_RS13110	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I1A55_RS13115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I1A55_RS13120	COG0237	dephospho-CoA kinase activity
I1A55_RS13125	COG1971	Probably functions as a manganese efflux pump
I1A55_RS13130	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I1A55_RS13135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1A55_RS13135	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1A55_RS13140	COG5002	protein histidine kinase activity
I1A55_RS13145	COG0745	RESPONSE REGULATOR receiver
I1A55_RS13150	COG0039	L-malate dehydrogenase activity
I1A55_RS13155	COG0538	isocitrate dehydrogenase activity
I1A55_RS13160	COG0372	Belongs to the citrate synthase family
I1A55_RS13165	COG2707	UPF0756 membrane protein
I1A55_RS13170	COG0628	permease
I1A55_RS13175	COG3030	protein affecting phage T7 exclusion by the F plasmid
I1A55_RS13185	COG0205	6-phosphofructokinase activity
I1A55_RS13190	COG0825	malonyl-CoA metabolic process
I1A55_RS13195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I1A55_RS13200	COG0281	malic enzyme
I1A55_RS13205	COG0587	DNA-directed DNA polymerase activity
I1A55_RS13225	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I1A55_RS13235	COG4109	DRTGG domain
I1A55_RS13240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I1A55_RS13245	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS13255	COG0165	Argininosuccinate lyase
I1A55_RS13260	COG0137	argininosuccinate synthase activity
I1A55_RS13265	COG0521	Mo-molybdopterin cofactor biosynthetic process
I1A55_RS13270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I1A55_RS13275	COG0827	DNA restriction-modification system
I1A55_RS13280	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I1A55_RS13285	COG3874	Sporulation protein YtfJ
I1A55_RS13295	COG1714	RDD family
I1A55_RS13300	COG0616	signal peptide processing
I1A55_RS13305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I1A55_RS13315	COG3239	Fatty acid desaturase
I1A55_RS13320	COG4585	Histidine kinase
I1A55_RS13325	COG2197	response regulator
I1A55_RS13330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I1A55_RS13335	COG0745	RESPONSE REGULATOR receiver
I1A55_RS13340	COG2205	protein histidine kinase activity
I1A55_RS13345	COG1136	(ABC) transporter
I1A55_RS13350	COG0577	efflux transmembrane transporter activity
I1A55_RS13355	COG0402	S-adenosylhomocysteine deaminase activity
I1A55_RS13360	COG2249	NAD(P)H dehydrogenase (quinone) activity
I1A55_RS13375	COG1279	arginine transmembrane transporter activity
I1A55_RS13380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1A55_RS13390	COG0301	tRNA thio-modification
I1A55_RS13395	COG1104	cysteine desulfurase activity
I1A55_RS13400	COG1114	Component of the transport system for branched-chain amino acids
I1A55_RS13405	COG1114	Component of the transport system for branched-chain amino acids
I1A55_RS13410	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I1A55_RS13415	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I1A55_RS13420	COG1309	transcriptional regulator
I1A55_RS13425	COG1956	GAF domain-containing protein
I1A55_RS13430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I1A55_RS13445	COG1335	isochorismatase
I1A55_RS13455	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I1A55_RS13460	COG2329	Antibiotic biosynthesis monooxygenase
I1A55_RS13465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I1A55_RS13470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1A55_RS13475	COG0454	-acetyltransferase
I1A55_RS13480	COG0517	IMP dehydrogenase activity
I1A55_RS13485	COG0123	including yeast histone deacetylase and acetoin utilization protein
I1A55_RS13490	COG1609	Transcriptional regulator
I1A55_RS13495	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I1A55_RS13495	COG1605	Chorismate mutase
I1A55_RS13500	COG3118	belongs to the thioredoxin family
I1A55_RS13505	COG4980	gas vesicle protein
I1A55_RS13510	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I1A55_RS13515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I1A55_RS13520	COG1674	ftsk spoiiie
I1A55_RS13525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I1A55_RS13530	COG4848	Belongs to the UPF0354 family
I1A55_RS13535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1A55_RS13550	COG1363	Peptidase, m42
I1A55_RS13555	COG5584	Small secreted protein
I1A55_RS13560	COG0281	malic enzyme
I1A55_RS13565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I1A55_RS13570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I1A55_RS13580	COG0510	thiamine kinase activity
I1A55_RS13585	COG1597	lipid kinase activity
I1A55_RS13595	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I1A55_RS13600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I1A55_RS13605	COG3340	Belongs to the peptidase S51 family
I1A55_RS13610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I1A55_RS13615	COG2252	PERMEase
I1A55_RS13620	COG1349	DNA-binding transcription factor activity
I1A55_RS13625	COG1187	pseudouridine synthase activity
I1A55_RS13630	COG2244	polysaccharide biosynthetic process
I1A55_RS13635	COG2081	HI0933 family
I1A55_RS13645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I1A55_RS13650	COG3196	Protein conserved in bacteria
I1A55_RS13660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I1A55_RS13665	COG5578	integral membrane protein
I1A55_RS13670	COG0673	inositol 2-dehydrogenase activity
I1A55_RS13675	COG1653	transport
I1A55_RS13680	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I1A55_RS13685	COG4209	transmembrane transport
I1A55_RS13690	COG2207	Transcriptional regulator
I1A55_RS13695	COG1733	regulation of RNA biosynthetic process
I1A55_RS13700	COG2814	Major facilitator Superfamily
I1A55_RS13705	COG0656	L-ascorbic acid biosynthetic process
I1A55_RS13710	COG1653	transport
I1A55_RS13715	COG0395	ABC-type sugar transport system, permease component
I1A55_RS13720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1A55_RS13725	COG1073	alpha beta
I1A55_RS13730	COG0495	leucyl-tRNA aminoacylation
I1A55_RS13740	COG1366	Belongs to the anti-sigma-factor antagonist family
I1A55_RS13740	COG2202	Pas domain
I1A55_RS13745	COG2433	Pfam Transposase IS66
I1A55_RS13750	COG0577	efflux transmembrane transporter activity
I1A55_RS13755	COG1136	(ABC) transporter
I1A55_RS13765	COG1131	(ABC) transporter
I1A55_RS13770	COG1725	Transcriptional regulator
I1A55_RS13790	COG1242	4 iron, 4 sulfur cluster binding
I1A55_RS13795	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I1A55_RS13800	COG4326	sporulation control protein
I1A55_RS13810	COG2267	carboxylic ester hydrolase activity
I1A55_RS13815	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I1A55_RS13820	COG0367	asparagine synthase
I1A55_RS13825	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I1A55_RS13830	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I1A55_RS13840	COG1506	peptidase
I1A55_RS13845	COG1233	COG1233 Phytoene dehydrogenase and related
I1A55_RS13865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1A55_RS13870	COG1116	anion transmembrane transporter activity
I1A55_RS13875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1A55_RS13880	COG0494	nUDIX hydrolase
I1A55_RS13885	COG2310	stress, protein
I1A55_RS13900	COG4824	toxin secretion phage lysis holin
I1A55_RS13910	COG0783	Belongs to the Dps family
I1A55_RS13925	COG1854	S-ribosylhomocysteine lyase activity
I1A55_RS13930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I1A55_RS13935	COG0288	reversible hydration of carbon dioxide
I1A55_RS13940	COG0803	Belongs to the bacterial solute-binding protein 9 family
I1A55_RS13940	COG3443	Belongs to the bacterial solute-binding protein 9 family
I1A55_RS13950	COG1271	oxidase subunit
I1A55_RS13955	COG1294	oxidase, subunit
I1A55_RS13970	COG4948	Mandelate Racemase Muconate Lactonizing
I1A55_RS13975	COG0318	PFAM AMP-dependent synthetase and ligase
I1A55_RS13980	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I1A55_RS13985	COG0596	Alpha beta hydrolase
I1A55_RS13990	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I1A55_RS13995	COG1169	isochorismate synthase
I1A55_RS14000	COG1575	Belongs to the MenA family. Type 1 subfamily
I1A55_RS14005	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I1A55_RS14135	COG3859	Proton-coupled thiamine transporter YuaJ
I1A55_RS14140	COG1247	-acetyltransferase
I1A55_RS14145	COG3339	Conserved Protein
I1A55_RS14150	COG0772	Belongs to the SEDS family
I1A55_RS14155	COG0772	Belongs to the SEDS family
I1A55_RS14160	COG2268	Band 7 protein
I1A55_RS14165	COG1585	Membrane protein implicated in regulation of membrane protease activity
I1A55_RS14170	COG2318	DinB family
I1A55_RS14175	COG1454	alcohol dehydrogenase
I1A55_RS14180	COG1012	belongs to the aldehyde dehydrogenase family
I1A55_RS14185	COG1510	regulation of RNA biosynthetic process
I1A55_RS14200	COG3409	Peptidoglycan-binding domain 1 protein
I1A55_RS14200	COG5632	N-Acetylmuramoyl-L-alanine amidase
I1A55_RS14255	COG3778	Protein conserved in bacteria
I1A55_RS14260	COG3299	homolog of phage Mu protein gp47
I1A55_RS14265	COG3628	GPW Gp25 family protein
I1A55_RS14275	COG4193	domain, Protein
I1A55_RS14280	COG1652	LysM domain
I1A55_RS14285	COG3953	SLT domain
I1A55_RS14285	COG5280	Phage tail tape measure protein TP901
I1A55_RS14285	COG5280	Phage tail tape measure protein TP901
I1A55_RS14285	COG3953	SLT domain
I1A55_RS14340	COG4653	Phage capsid family
I1A55_RS14345	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I1A55_RS14350	COG5518	Phage portal protein
I1A55_RS14355	COG1783	phage Terminase large subunit
I1A55_RS14360	COG5484	DNA packaging
I1A55_RS14365	COG1595	DNA-templated transcription, initiation
I1A55_RS14375	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I1A55_RS14395	COG1396	sequence-specific DNA binding
I1A55_RS14405	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I1A55_RS14420	COG0628	permease
I1A55_RS14430	COG0673	inositol 2-dehydrogenase activity
I1A55_RS14435	COG0693	protein deglycase activity
I1A55_RS14440	COG0840	transmembrane signaling receptor activity
I1A55_RS14445	COG0840	transmembrane signaling receptor activity
I1A55_RS14450	COG0840	transmembrane signaling receptor activity
I1A55_RS14455	COG0840	transmembrane signaling receptor activity
I1A55_RS14470	COG2070	2-Nitropropane dioxygenase
I1A55_RS14475	COG0432	Pfam Uncharacterised protein family UPF0047
I1A55_RS14480	COG1253	flavin adenine dinucleotide binding
I1A55_RS14485	COG2738	Putative neutral zinc metallopeptidase
I1A55_RS14495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I1A55_RS14510	COG0166	Belongs to the GPI family
I1A55_RS14515	COG1979	alcohol dehydrogenase
I1A55_RS14520	COG1979	alcohol dehydrogenase
I1A55_RS14525	COG2155	Conserved Protein
I1A55_RS14530	COG1098	S1 RNA binding domain
I1A55_RS14535	COG0436	Aminotransferase
I1A55_RS14540	COG1522	sequence-specific DNA binding
I1A55_RS14545	COG2267	carboxylic ester hydrolase activity
I1A55_RS14555	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I1A55_RS14560	COG2205	protein histidine kinase activity
I1A55_RS14575	COG5018	Exonuclease
I1A55_RS14580	COG2814	Major facilitator Superfamily
I1A55_RS14585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1A55_RS14590	COG3011	Protein conserved in bacteria
I1A55_RS14600	COG3290	protein histidine kinase activity
I1A55_RS14605	COG4565	transcriptional regulatory protein
I1A55_RS14610	COG1744	ABC transporter substrate-binding protein PnrA-like
I1A55_RS14615	COG3845	ABC transporter
I1A55_RS14620	COG4603	Belongs to the binding-protein-dependent transport system permease family
I1A55_RS14625	COG1079	Belongs to the binding-protein-dependent transport system permease family
I1A55_RS14630	COG3493	citrate carrier protein
I1A55_RS14640	COG2111	Na H antiporter
I1A55_RS14640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I1A55_RS14645	COG2111	Na H antiporter
I1A55_RS14650	COG1006	Multisubunit Na H antiporter MnhC subunit
I1A55_RS14655	COG0651	ATP synthesis coupled electron transport
I1A55_RS14660	COG1863	multisubunit Na H antiporter MnhE subunit
I1A55_RS14665	COG2212	antiporter activity
I1A55_RS14670	COG1320	monovalent cation:proton antiporter activity
I1A55_RS14675	COG2050	protein possibly involved in aromatic compounds catabolism
I1A55_RS14680	COG2197	response regulator
I1A55_RS14685	COG4585	Histidine kinase
I1A55_RS14695	COG0142	geranyltranstransferase activity
I1A55_RS14710	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I1A55_RS14715	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I1A55_RS14720	COG1335	isochorismatase
I1A55_RS14725	COG5506	Protein of unknown function (DUF1694)
I1A55_RS14745	COG0628	permease
I1A55_RS14760	COG1418	mRNA catabolic process
I1A55_RS14765	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS14775	COG1511	domain protein
I1A55_RS14780	COG0433	COG0433 Predicted ATPase
I1A55_RS14780	COG1674	ftsk spoiiie
I1A55_RS14785	COG4499	WXG100 protein secretion system (Wss), protein YukC
I1A55_RS14790	COG5417	Belongs to the EsaB family
I1A55_RS14795	COG4842	Belongs to the WXG100 family
I1A55_RS14800	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I1A55_RS14800	COG2508	Transcriptional regulator
I1A55_RS14805	COG0686	Belongs to the AlaDH PNT family
I1A55_RS14810	COG1268	BioY protein
I1A55_RS14815	COG2056	Na+-H+ antiporter family
I1A55_RS14820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I1A55_RS14825	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I1A55_RS14830	COG3584	3D domain protein
I1A55_RS14845	COG1252	NADH dehydrogenase
I1A55_RS14850	COG0492	ferredoxin-NADP+ reductase activity
I1A55_RS14865	COG0789	Transcriptional regulator
I1A55_RS14870	COG5504	Zn-dependent protease
I1A55_RS14875	COG0316	Belongs to the HesB IscA family
I1A55_RS14880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I1A55_RS14885	COG4844	belongs to the
I1A55_RS14890	COG1252	NADH dehydrogenase
I1A55_RS14900	COG4837	Protein of unknown function (DUF1462)
I1A55_RS14905	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I1A55_RS14910	COG1506	peptidase
I1A55_RS14910	COG4946	Tricorn protease homolog
I1A55_RS14910	COG0823	Involved in the tonB-independent uptake of proteins
I1A55_RS14915	COG0083	homoserine kinase activity
I1A55_RS14920	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I1A55_RS14925	COG0460	homoserine dehydrogenase
I1A55_RS14930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I1A55_RS14935	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I1A55_RS14940	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I1A55_RS14945	COG0647	UMP catabolic process
I1A55_RS14950	COG2445	Protein of unknown function DUF86
I1A55_RS14955	COG4470	Protein conserved in bacteria
I1A55_RS14965	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I1A55_RS14970	COG0739	heme binding
I1A55_RS14990	COG3377	Domain of unknown function (DUF1805)
I1A55_RS14995	COG0737	Belongs to the 5'-nucleotidase family
I1A55_RS15000	COG1801	Protein of unknown function DUF72
I1A55_RS15005	COG2508	Transcriptional regulator
I1A55_RS15010	COG2140	Oxalate decarboxylase
I1A55_RS15015	COG2814	Major facilitator Superfamily
I1A55_RS15020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I1A55_RS15025	COG2356	endonuclease I
I1A55_RS15035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A55_RS15040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A55_RS15045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I1A55_RS15065	COG5002	protein histidine kinase activity
I1A55_RS15065	COG0642	Histidine kinase
I1A55_RS15070	COG0745	RESPONSE REGULATOR receiver
I1A55_RS15075	COG2311	Membrane
I1A55_RS15085	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I1A55_RS15090	COG1090	epimerase
I1A55_RS15095	COG1309	transcriptional regulator
I1A55_RS15105	COG0719	Fe-S assembly protein
I1A55_RS15110	COG0822	iron-sulfur transferase activity
I1A55_RS15115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I1A55_RS15120	COG0719	Fe-S assembly protein
I1A55_RS15125	COG0396	ATPase activity
I1A55_RS15135	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I1A55_RS15140	COG1464	Belongs to the NlpA lipoprotein family
I1A55_RS15145	COG2011	ABC-type metal ion transport system permease component
I1A55_RS15150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I1A55_RS15160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1A55_RS15165	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I1A55_RS15175	COG0509	glycine decarboxylation via glycine cleavage system
I1A55_RS15180	COG1393	Belongs to the ArsC family
I1A55_RS15185	COG1960	acyl-CoA dehydrogenase activity
I1A55_RS15190	COG0183	Belongs to the thiolase family
I1A55_RS15195	COG1250	3-hydroxyacyl-CoA dehydrogenase
I1A55_RS15195	COG1024	Enoyl-CoA hydratase
I1A55_RS15210	COG5577	PFAM Coat F domain
I1A55_RS15220	COG1120	ATPase activity
I1A55_RS15230	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS15235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1A55_RS15240	COG0745	RESPONSE REGULATOR receiver
I1A55_RS15245	COG2205	protein histidine kinase activity
I1A55_RS15245	COG2770	Histidine kinase
I1A55_RS15255	COG1309	transcriptional regulator
I1A55_RS15260	COG0114	fumarate hydratase activity
I1A55_RS15270	COG0697	spore germination
I1A55_RS15275	COG0814	amino acid
I1A55_RS15290	COG2197	response regulator
I1A55_RS15295	COG4585	Histidine kinase
I1A55_RS15300	COG4758	membrane
I1A55_RS15310	COG1842	Phage shock protein A
I1A55_RS15315	COG4758	membrane
I1A55_RS15320	COG2096	Adenosyltransferase
I1A55_RS15325	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS15330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I1A55_RS15340	COG3604	Transcriptional regulator
I1A55_RS15355	COG1454	alcohol dehydrogenase
I1A55_RS15360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I1A55_RS15365	COG1120	ATPase activity
I1A55_RS15370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A55_RS15375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I1A55_RS15385	COG2721	sulfolactate sulfo-lyase activity
I1A55_RS15390	COG0246	Mannitol dehydrogenase
I1A55_RS15395	COG1609	Transcriptional regulator
I1A55_RS15400	COG1904	glucuronate isomerase
I1A55_RS15405	COG2205	protein histidine kinase activity
I1A55_RS15410	COG0745	RESPONSE REGULATOR receiver
I1A55_RS15415	COG1120	ATPase activity
I1A55_RS15420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A55_RS15425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A55_RS15430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I1A55_RS15435	COG0531	amino acid
I1A55_RS15450	COG1988	membrane-bound metal-dependent
I1A55_RS15455	COG1368	sulfuric ester hydrolase activity
I1A55_RS15460	COG0725	ABC transporter, periplasmic molybdate-binding protein
I1A55_RS15465	COG4149	molybdate abc transporter
I1A55_RS15470	COG0656	L-ascorbic acid biosynthetic process
I1A55_RS15475	COG1940	carbohydrate kinase activity
I1A55_RS15480	COG0025	NhaP-type Na H and K H
I1A55_RS15485	COG2860	membrane
I1A55_RS15490	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I1A55_RS15495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I1A55_RS15500	COG2217	Heavy metal translocating P-type atpase
I1A55_RS15505	COG1121	(ABC) transporter
I1A55_RS15510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I1A55_RS15515	COG0803	Belongs to the bacterial solute-binding protein 9 family
I1A55_RS15525	COG3226	Transcriptional regulator
I1A55_RS15530	COG0784	Response regulator, receiver
I1A55_RS15535	COG4191	Histidine kinase
I1A55_RS15540	COG1027	Aspartate ammonia-lyase
I1A55_RS15555	COG2217	Heavy metal translocating P-type atpase
I1A55_RS15560	COG2608	mercury ion transmembrane transporter activity
I1A55_RS15565	COG1937	Protein conserved in bacteria
I1A55_RS15600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I1A55_RS15605	COG0557	exoribonuclease II activity
I1A55_RS15610	COG1647	Serine aminopeptidase, S33
I1A55_RS15615	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I1A55_RS15620	COG2002	toxin-antitoxin pair type II binding
I1A55_RS15625	COG1476	TRANSCRIPTIONal
I1A55_RS15630	COG1396	sequence-specific DNA binding
I1A55_RS15635	COG1396	sequence-specific DNA binding
I1A55_RS15640	COG1733	regulation of RNA biosynthetic process
I1A55_RS15645	COG1174	glycine betaine transport
I1A55_RS15650	COG1732	Glycine betaine
I1A55_RS15655	COG1174	glycine betaine transport
I1A55_RS15660	COG0517	IMP dehydrogenase activity
I1A55_RS15660	COG1125	glycine betaine transport
I1A55_RS15665	COG1510	regulation of RNA biosynthetic process
I1A55_RS15670	COG2095	MarC family integral membrane protein
I1A55_RS15680	COG0456	acetyltransferase
I1A55_RS15700	COG1131	(ABC) transporter
I1A55_RS15710	COG0148	phosphopyruvate hydratase activity
I1A55_RS15715	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I1A55_RS15720	COG0149	triose-phosphate isomerase activity
I1A55_RS15725	COG0126	phosphoglycerate kinase activity
I1A55_RS15730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I1A55_RS15735	COG2390	Transcriptional regulator
I1A55_RS15740	COG0833	amino acid
I1A55_RS15745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I1A55_RS15750	COG3829	transcription factor binding
I1A55_RS15755	COG2186	Transcriptional regulator
I1A55_RS15760	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I1A55_RS15770	COG0534	Mate efflux family protein
I1A55_RS15775	COG4608	Belongs to the ABC transporter superfamily
I1A55_RS15780	COG0444	Belongs to the ABC transporter superfamily
I1A55_RS15785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A55_RS15790	COG0601	transmembrane transport
I1A55_RS15795	COG0747	negative chemotaxis
I1A55_RS15800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I1A55_RS15805	COG0110	maltose O-acetyltransferase activity
I1A55_RS15810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I1A55_RS15815	COG2244	polysaccharide biosynthetic process
I1A55_RS15820	COG5039	Polysaccharide pyruvyl transferase
I1A55_RS15825	COG1216	Glycosyl transferase, family 2
I1A55_RS15835	COG0438	transferase activity, transferring glycosyl groups
I1A55_RS15840	COG1215	transferase activity, transferring glycosyl groups
I1A55_RS15845	COG0438	transferase activity, transferring glycosyl groups
I1A55_RS15850	COG1086	Polysaccharide biosynthesis protein
I1A55_RS15855	COG0489	protein tyrosine kinase activity
I1A55_RS15860	COG3944	biosynthesis protein
I1A55_RS15865	COG1396	sequence-specific DNA binding
I1A55_RS15875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I1A55_RS15880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A55_RS15885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A55_RS15890	COG0726	polysaccharide deacetylase
I1A55_RS15895	COG0488	(ABC) transporter
I1A55_RS15900	COG4608	Belongs to the ABC transporter superfamily
I1A55_RS15915	COG0601	transmembrane transport
I1A55_RS15920	COG0747	negative chemotaxis
I1A55_RS15925	COG1819	glycosyl
I1A55_RS15940	COG0740	serine-type endopeptidase activity
I1A55_RS15945	COG1611	Belongs to the LOG family
I1A55_RS15950	COG1694	Mazg nucleotide pyrophosphohydrolase
I1A55_RS15955	COG0659	secondary active sulfate transmembrane transporter activity
I1A55_RS15960	COG0288	reversible hydration of carbon dioxide
I1A55_RS15965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I1A55_RS15980	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I1A55_RS15985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A55_RS15990	COG1481	regulation of sporulation
I1A55_RS15995	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I1A55_RS16000	COG1660	Displays ATPase and GTPase activities
I1A55_RS16005	COG1051	belongs to the nudix hydrolase family
I1A55_RS16010	COG0492	ferredoxin-NADP+ reductase activity
I1A55_RS16015	COG3883	PFAM NLP P60 protein
I1A55_RS16015	COG0791	NLP P60 protein
I1A55_RS16020	COG0457	Tetratricopeptide repeat
I1A55_RS16025	COG0140	phosphoribosyl-ATP diphosphatase activity
I1A55_RS16025	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I1A55_RS16030	COG0107	imidazoleglycerol-phosphate synthase activity
I1A55_RS16035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I1A55_RS16040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I1A55_RS16045	COG0131	Imidazoleglycerol-phosphate dehydratase
I1A55_RS16050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I1A55_RS16055	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I1A55_RS16060	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I1A55_RS16065	COG4990	cell redox homeostasis
I1A55_RS16075	COG2910	NAD(P)H-binding
I1A55_RS16080	COG1959	2 iron, 2 sulfur cluster binding
I1A55_RS16085	COG0110	maltose O-acetyltransferase activity
I1A55_RS16090	COG0546	phosphoglycolate phosphatase activity
I1A55_RS16095	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I1A55_RS16105	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I1A55_RS16110	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I1A55_RS16115	COG0363	glucosamine-6-phosphate deaminase activity
I1A55_RS16120	COG2188	Transcriptional regulator
I1A55_RS16125	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I1A55_RS16130	COG1950	PFAM Membrane protein of
I1A55_RS16135	COG1983	PspC domain protein
I1A55_RS16140	COG3595	metallopeptidase activity
I1A55_RS16155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I1A55_RS16165	COG4897	Protein conserved in bacteria
I1A55_RS16170	COG0574	Belongs to the PEP-utilizing enzyme family
I1A55_RS16170	COG3848	Pyruvate phosphate dikinase
I1A55_RS16175	COG1309	transcriptional regulator
I1A55_RS16180	COG2814	Major facilitator Superfamily
I1A55_RS16190	COG0745	RESPONSE REGULATOR receiver
I1A55_RS16195	COG5002	protein histidine kinase activity
I1A55_RS16200	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I1A55_RS16205	COG0463	Glycosyl transferase, family 2
I1A55_RS16210	COG1113	amino acid transport
I1A55_RS16215	COG0778	Nitroreductase
I1A55_RS16220	COG1733	regulation of RNA biosynthetic process
I1A55_RS16225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1A55_RS16235	COG3409	Peptidoglycan-binding domain 1 protein
I1A55_RS16235	COG0793	Belongs to the peptidase S41A family
I1A55_RS16240	COG0730	response to heat
I1A55_RS16245	COG3883	PFAM NLP P60 protein
I1A55_RS16245	COG0791	NLP P60 protein
I1A55_RS16250	COG2177	Part of the ABC transporter FtsEX involved in
I1A55_RS16255	COG2884	Cell division ATP-binding protein ftsE
I1A55_RS16260	COG2010	Cytochrome c
I1A55_RS16265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I1A55_RS16285	COG0653	protein targeting
I1A55_RS16290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I1A55_RS16295	COG0840	transmembrane signaling receptor activity
I1A55_RS16310	COG1516	flagellar protein fliS
I1A55_RS16315	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I1A55_RS16320	COG1334	flagellar protein FlaG
I1A55_RS16325	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I1A55_RS16330	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
I1A55_RS16340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I1A55_RS16345	COG1256	bacterial-type flagellum assembly
I1A55_RS16345	COG4786	Flagellar basal body rod
I1A55_RS16350	COG3418	PFAM FlgN family protein
I1A55_RS16365	COG1040	competence protein
I1A55_RS16375	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I1A55_RS16380	COG1307	EDD domain protein, DegV family
I1A55_RS16385	COG2197	response regulator
I1A55_RS16390	COG4585	Histidine kinase
I1A55_RS16395	COG1739	Uncharacterized protein family UPF0029
I1A55_RS16400	COG1316	TRANSCRIPTIONal
I1A55_RS16405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I1A55_RS16410	COG0438	transferase activity, transferring glycosyl groups
I1A55_RS16415	COG1215	transferase activity, transferring glycosyl groups
I1A55_RS16420	COG3206	protein involved in exopolysaccharide biosynthesis
I1A55_RS16425	COG3307	-O-antigen
I1A55_RS16430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1A55_RS16435	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I1A55_RS16440	COG0438	transferase activity, transferring glycosyl groups
I1A55_RS16440	COG0297	glycogen (starch) synthase activity
I1A55_RS16445	COG2244	polysaccharide biosynthetic process
I1A55_RS16460	COG2247	cell wall binding repeat
I1A55_RS16460	COG0860	N-Acetylmuramoyl-L-alanine amidase
I1A55_RS16465	COG2247	cell wall binding repeat
I1A55_RS16465	COG0860	N-Acetylmuramoyl-L-alanine amidase
I1A55_RS16470	COG2385	sporulation resulting in formation of a cellular spore
I1A55_RS16470	COG2247	cell wall binding repeat
I1A55_RS16480	COG1316	TRANSCRIPTIONal
I1A55_RS16485	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I1A55_RS16490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I1A55_RS16495	COG1134	teichoic acid transport
I1A55_RS16500	COG1682	transport, permease protein
I1A55_RS16505	COG0463	Glycosyl transferase, family 2
I1A55_RS16505	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I1A55_RS16510	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I1A55_RS16520	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I1A55_RS16525	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I1A55_RS16530	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I1A55_RS16535	COG4193	domain, Protein
I1A55_RS16540	COG1482	cell wall glycoprotein biosynthetic process
I1A55_RS16550	COG1175	transmembrane transport
I1A55_RS16555	COG1653	transport
I1A55_RS16560	COG2197	response regulator
I1A55_RS16565	COG2972	Histidine kinase
I1A55_RS16575	COG0454	-acetyltransferase
I1A55_RS16580	COG0800	Aldolase
I1A55_RS16585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I1A55_RS16590	COG1609	Transcriptional regulator
I1A55_RS16595	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I1A55_RS16600	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS16605	COG0697	spore germination
I1A55_RS16610	COG0814	amino acid
I1A55_RS16625	COG2814	Major facilitator Superfamily
I1A55_RS16630	COG1316	TRANSCRIPTIONal
I1A55_RS16635	COG0561	phosphatase activity
I1A55_RS16640	COG0791	NLP P60 protein
I1A55_RS16650	COG2843	Capsule synthesis protein
I1A55_RS16660	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I1A55_RS16665	COG0697	spore germination
I1A55_RS16680	COG1609	Transcriptional regulator
I1A55_RS16685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I1A55_RS16690	COG1869	D-ribose catabolic process
I1A55_RS16695	COG1129	ABC transporter
I1A55_RS16700	COG1172	Belongs to the binding-protein-dependent transport system permease family
I1A55_RS16705	COG1879	ABC-type sugar transport system periplasmic component
I1A55_RS16710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1A55_RS16715	COG0583	DNA-binding transcription factor activity
I1A55_RS16720	COG0028	Belongs to the TPP enzyme family
I1A55_RS16725	COG3527	Alpha-acetolactate decarboxylase
I1A55_RS16730	COG1522	sequence-specific DNA binding
I1A55_RS16735	COG2059	Chromate
I1A55_RS16740	COG2059	Chromate
I1A55_RS16745	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I1A55_RS16755	COG4715	Zinc finger, swim domain protein
I1A55_RS16760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I1A55_RS16765	COG2202	Pas domain
I1A55_RS16765	COG1366	Belongs to the anti-sigma-factor antagonist family
I1A55_RS16770	COG0561	phosphatase activity
I1A55_RS16785	COG1970	mechanosensitive ion channel activity
I1A55_RS16790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I1A55_RS16795	COG0457	Tetratricopeptide repeat
I1A55_RS16800	COG4786	Flagellar basal body rod
I1A55_RS16805	COG4786	Flagellar basal body rod
I1A55_RS16810	COG1077	Cell shape determining protein MreB Mrl
I1A55_RS16815	COG1609	Transcriptional regulator
I1A55_RS16820	COG1846	Transcriptional regulator
I1A55_RS16825	COG2814	Major facilitator Superfamily
I1A55_RS16830	COG0671	phosphoesterase, PA-phosphatase related
I1A55_RS16835	COG0477	Major facilitator Superfamily
I1A55_RS16840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1A55_RS16845	COG0765	amino acid transport
I1A55_RS16850	COG1126	abc transporter atp-binding protein
I1A55_RS16855	COG0004	ammonium transporteR
I1A55_RS16860	COG0347	Belongs to the P(II) protein family
I1A55_RS16865	COG0739	heme binding
I1A55_RS16870	COG1247	-acetyltransferase
I1A55_RS16905	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I1A55_RS16910	COG0523	cobalamin synthesis protein
I1A55_RS16915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I1A55_RS16920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I1A55_RS16925	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I1A55_RS16930	COG2223	nitrite transmembrane transporter activity
I1A55_RS16940	COG2304	oxidoreductase activity
I1A55_RS16945	COG2304	oxidoreductase activity
I1A55_RS16950	COG2385	sporulation resulting in formation of a cellular spore
I1A55_RS16955	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I1A55_RS16965	COG4836	Membrane
I1A55_RS16975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I1A55_RS16980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I1A55_RS16985	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I1A55_RS16990	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I1A55_RS16995	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I1A55_RS17000	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I1A55_RS17005	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I1A55_RS17010	COG0356	it plays a direct role in the translocation of protons across the membrane
I1A55_RS17020	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I1A55_RS17025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I1A55_RS17030	COG4475	Protein of unknown function (DUF436)
I1A55_RS17035	COG0698	ribose 5-phosphate isomerase
I1A55_RS17040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I1A55_RS17045	COG1971	Probably functions as a manganese efflux pump
I1A55_RS17050	COG0009	L-threonylcarbamoyladenylate synthase
I1A55_RS17055	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I1A55_RS17070	COG2890	protein-(glutamine-N5) methyltransferase activity
I1A55_RS17075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I1A55_RS17080	COG0789	Transcriptional regulator
I1A55_RS17085	COG0679	Auxin Efflux Carrier
I1A55_RS17090	COG0281	malic enzyme
I1A55_RS17095	COG1435	thymidine kinase activity
I1A55_RS17100	COG0254	rRNA binding
I1A55_RS17105	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I1A55_RS17110	COG1494	fructose-1,6-bisphosphatase
I1A55_RS17115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I1A55_RS17120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I1A55_RS17125	COG0191	fructose-bisphosphate aldolase activity
I1A55_RS17130	COG2204	response regulator
I1A55_RS17135	COG4821	SIS domain
I1A55_RS17140	COG0504	CTP synthase activity
I1A55_RS17145	COG3343	RNA polymerase activity
I1A55_RS17160	COG1960	acyl-CoA dehydrogenase activity
I1A55_RS17165	COG1960	acyl-CoA dehydrogenase activity
I1A55_RS17170	COG1250	3-hydroxyacyl-CoA dehydrogenase
I1A55_RS17175	COG0183	Belongs to the thiolase family
I1A55_RS17180	COG0247	lactate metabolic process
I1A55_RS17180	COG2181	nitrate reductase activity
I1A55_RS17185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I1A55_RS17190	COG4294	response to UV
I1A55_RS17200	COG1619	proteins homologs of microcin C7 resistance protein MccF
I1A55_RS17210	COG1132	(ABC) transporter
I1A55_RS17215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I1A55_RS17220	COG1619	proteins homologs of microcin C7 resistance protein MccF
I1A55_RS17225	COG0018	arginyl-trna synthetase
I1A55_RS17230	COG4506	Protein conserved in bacteria
I1A55_RS17240	COG0010	Belongs to the arginase family
I1A55_RS17245	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I1A55_RS17250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1A55_RS17260	COG1994	Peptidase M50
I1A55_RS17265	COG1942	4-Oxalocrotonate Tautomerase
I1A55_RS17275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A55_RS17280	COG0583	DNA-binding transcription factor activity
I1A55_RS17285	COG0431	NADPH-dependent FMN reductase
I1A55_RS17290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A55_RS17295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I1A55_RS17300	COG0454	-acetyltransferase
I1A55_RS17305	COG0765	amino acid transport
I1A55_RS17315	COG0765	amino acid transport
I1A55_RS17320	COG1126	abc transporter atp-binding protein
I1A55_RS17325	COG3465	dGTPase activity
I1A55_RS17330	COG1078	dGTPase activity
I1A55_RS17335	COG4844	belongs to the
I1A55_RS17385	COG5444	nuclease activity
I1A55_RS17415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I1A55_RS17425	COG0280	phosphate acetyltransferase
I1A55_RS17435	COG2814	Major facilitator Superfamily
I1A55_RS17440	COG1522	sequence-specific DNA binding
I1A55_RS17445	COG2814	Major facilitator Superfamily
I1A55_RS17450	COG0077	Prephenate dehydratase
I1A55_RS17455	COG1917	Cupin 2, conserved barrel domain protein
I1A55_RS17460	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS17465	COG0151	Belongs to the GarS family
I1A55_RS17470	COG0436	Aminotransferase
I1A55_RS17475	COG1028	Short-chain dehydrogenase reductase Sdr
I1A55_RS17480	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I1A55_RS17485	COG1091	dTDP-4-dehydrorhamnose reductase activity
I1A55_RS17490	COG1088	dTDP-glucose 4,6-dehydratase activity
I1A55_RS17495	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I1A55_RS17500	COG3980	spore coat polysaccharide biosynthesis protein
I1A55_RS17505	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
I1A55_RS17510	COG2089	acid synthase
I1A55_RS17515	COG0456	acetyltransferase
I1A55_RS17520	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I1A55_RS17525	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I1A55_RS17530	COG0463	Glycosyl transferase, family 2
I1A55_RS17550	COG2363	Small membrane protein
I1A55_RS17555	COG2233	PERMEase
I1A55_RS17565	COG1012	belongs to the aldehyde dehydrogenase family
I1A55_RS17570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I1A55_RS17575	COG1216	Glycosyl transferase, family 2
I1A55_RS17585	COG0351	phosphomethylpyrimidine kinase
I1A55_RS17600	COG1621	beta-fructofuranosidase activity
I1A55_RS17605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A55_RS17605	COG1263	PTS System
I1A55_RS17610	COG3711	transcriptional antiterminator
I1A55_RS17620	COG1404	Belongs to the peptidase S8 family
I1A55_RS17630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A55_RS17635	COG0778	Nitroreductase
I1A55_RS17640	COG0772	Belongs to the SEDS family
I1A55_RS17650	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I1A55_RS17655	COG1845	cytochrome c oxidase, subunit III
I1A55_RS17660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I1A55_RS17665	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I1A55_RS17675	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I1A55_RS17680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I1A55_RS17685	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I1A55_RS17700	COG2246	polysaccharide biosynthetic process
I1A55_RS17725	COG0457	Tetratricopeptide repeat
I1A55_RS17735	COG3162	membrane
I1A55_RS17740	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I1A55_RS17755	COG0352	thiamine-phosphate diphosphorylase activity
I1A55_RS17760	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I1A55_RS17765	COG0583	DNA-binding transcription factor activity
I1A55_RS17770	COG1380	Effector of murein hydrolase LrgA
I1A55_RS17775	COG1346	cytolysis
I1A55_RS17780	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I1A55_RS17785	COG0346	lactoylglutathione lyase activity
I1A55_RS17795	COG0765	amino acid transport
I1A55_RS17800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1A55_RS17805	COG0457	Tetratricopeptide repeat
I1A55_RS17815	COG2357	RelA SpoT domain protein
I1A55_RS17820	COG1172	Belongs to the binding-protein-dependent transport system permease family
I1A55_RS17825	COG1129	ABC transporter
I1A55_RS17835	COG3420	alginic acid biosynthetic process
I1A55_RS17840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I1A55_RS17850	COG1486	melibiose metabolic process
I1A55_RS17855	COG1447	Phosphotransferase system cellobiose-specific component IIA
I1A55_RS17860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I1A55_RS17865	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I1A55_RS17870	COG3711	transcriptional antiterminator
I1A55_RS17870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A55_RS17885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I1A55_RS17900	COG1595	DNA-templated transcription, initiation
I1A55_RS17910	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I1A55_RS17915	COG4988	ABC transporter
I1A55_RS17920	COG1294	oxidase, subunit
I1A55_RS17925	COG1271	oxidase subunit
I1A55_RS17930	COG1120	ATPase activity
I1A55_RS17935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A55_RS17940	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I1A55_RS17945	COG4509	Sortase family
I1A55_RS17970	COG5386	Cell surface protein
I1A55_RS17975	COG5386	Cell surface protein
I1A55_RS17980	COG1733	regulation of RNA biosynthetic process
I1A55_RS17985	COG2514	catechol 2,3-dioxygenase activity
I1A55_RS17990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I1A55_RS17990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I1A55_RS17995	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I1A55_RS17995	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I1A55_RS18005	COG0726	polysaccharide deacetylase
I1A55_RS18010	COG1447	Phosphotransferase system cellobiose-specific component IIA
I1A55_RS18015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I1A55_RS18020	COG2723	6-phospho-beta-galactosidase activity
I1A55_RS18025	COG1312	Catalyzes the dehydration of D-mannonate
I1A55_RS18030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I1A55_RS18035	COG3711	transcriptional antiterminator
I1A55_RS18035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A55_RS18060	COG1757	Na H antiporter
I1A55_RS18065	COG1027	Aspartate ammonia-lyase
I1A55_RS18070	COG0252	asparaginase activity
I1A55_RS18075	COG1396	sequence-specific DNA binding
I1A55_RS18100	COG4842	Belongs to the WXG100 family
I1A55_RS18105	COG2195	Cleaves the N-terminal amino acid of tripeptides
I1A55_RS18120	COG1737	Transcriptional regulator
I1A55_RS18125	COG2084	Dehydrogenase
I1A55_RS18135	COG2610	gluconate transmembrane transporter activity
I1A55_RS18140	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I1A55_RS18165	COG2723	6-phospho-beta-galactosidase activity
I1A55_RS18170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A55_RS18170	COG2190	(PTS) system
I1A55_RS18170	COG1263	PTS System
I1A55_RS18175	COG3711	transcriptional antiterminator
I1A55_RS18180	COG3878	Protein conserved in bacteria
I1A55_RS18190	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I1A55_RS18195	COG1122	ATPase activity
I1A55_RS18200	COG4721	ABC-type cobalt transport system, permease component
I1A55_RS18205	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I1A55_RS18240	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I1A55_RS18245	COG0778	Nitroreductase
I1A55_RS18250	COG1846	Transcriptional regulator
I1A55_RS18255	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I1A55_RS18260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I1A55_RS18265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I1A55_RS18270	COG2390	Transcriptional regulator
I1A55_RS18280	COG2755	lipolytic protein G-D-S-L family
I1A55_RS18280	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I1A55_RS18285	COG0477	Major facilitator Superfamily
I1A55_RS18290	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I1A55_RS18295	COG2226	methyltransferase
I1A55_RS18305	COG0561	phosphatase activity
I1A55_RS18310	COG0789	Transcriptional regulator
I1A55_RS18315	COG0673	inositol 2-dehydrogenase activity
I1A55_RS18325	COG0840	transmembrane signaling receptor activity
I1A55_RS18330	COG1113	amino acid transport
I1A55_RS18335	COG4335	DNA alkylation repair
I1A55_RS18345	COG1070	Carbohydrate kinase
I1A55_RS18350	COG1737	Transcriptional regulator
I1A55_RS18395	COG0583	DNA-binding transcription factor activity
I1A55_RS18400	COG1609	Transcriptional regulator
I1A55_RS18405	COG2182	Extracellular solute-binding protein
I1A55_RS18410	COG1175	transmembrane transport
I1A55_RS18415	COG3833	ABC-type maltose transport systems, permease component
I1A55_RS18425	COG1874	Beta-galactosidase
I1A55_RS18430	COG2851	Citrate transporter
I1A55_RS18440	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I1A55_RS18445	COG1131	(ABC) transporter
I1A55_RS18450	COG2824	Alkylphosphonate utilization operon protein PhnA
I1A55_RS18455	COG1929	Belongs to the glycerate kinase type-1 family
I1A55_RS18460	COG2610	gluconate transmembrane transporter activity
I1A55_RS18465	COG3835	regulator
I1A55_RS18470	COG1309	transcriptional regulator
I1A55_RS18475	COG2814	Major facilitator Superfamily
I1A55_RS18485	COG1136	(ABC) transporter
I1A55_RS18490	COG0457	Tetratricopeptide repeat
I1A55_RS18495	COG3711	transcriptional antiterminator
I1A55_RS18500	COG2723	6-phospho-beta-galactosidase activity
I1A55_RS18505	COG1263	PTS System
I1A55_RS18505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A55_RS18505	COG2190	(PTS) system
I1A55_RS18530	COG0494	nUDIX hydrolase
I1A55_RS18545	COG1113	amino acid transport
I1A55_RS18550	COG1609	Transcriptional regulator
I1A55_RS18555	COG2814	Major facilitator Superfamily
I1A55_RS18560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I1A55_RS18565	COG2814	Major facilitator Superfamily
I1A55_RS18590	COG5444	nuclease activity
I1A55_RS18610	COG2723	6-phospho-beta-galactosidase activity
I1A55_RS18620	COG2188	Transcriptional regulator
I1A55_RS18635	COG0384	phenazine biosynthesis protein PhzF
I1A55_RS18640	COG0583	DNA-binding transcription factor activity
I1A55_RS18660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1A55_RS18665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I1A55_RS18690	COG0210	DNA helicase
I1A55_RS18695	COG0210	DNA helicase
I1A55_RS18700	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I1A55_RS18710	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I1A55_RS18720	COG4720	Psort location CytoplasmicMembrane, score
I1A55_RS18740	COG0456	acetyltransferase
I1A55_RS18745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1A55_RS18750	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I1A55_RS18755	COG4853	Protein conserved in bacteria
I1A55_RS18760	COG4863	YycH protein
I1A55_RS18765	COG5002	protein histidine kinase activity
I1A55_RS18770	COG0745	RESPONSE REGULATOR receiver
I1A55_RS18795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I1A55_RS18805	COG2311	Membrane
I1A55_RS18810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I1A55_RS18815	COG1309	transcriptional regulator
I1A55_RS18820	COG2124	cytochrome p450
I1A55_RS18825	COG0346	lactoylglutathione lyase activity
I1A55_RS18830	COG0305	Participates in initiation and elongation during chromosome replication
I1A55_RS18845	COG2819	hydrolase of the alpha beta superfamily
I1A55_RS18850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I1A55_RS18850	COG2207	Transcriptional regulator
I1A55_RS18855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I1A55_RS18860	COG2819	hydrolase of the alpha beta superfamily
I1A55_RS18865	COG3093	addiction module antidote protein HigA
I1A55_RS18870	COG2807	transmembrane transport
I1A55_RS18875	COG0359	binds to the 23S rRNA
I1A55_RS18880	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I1A55_RS18885	COG4241	membrane
I1A55_RS18890	COG1227	inorganic diphosphatase activity
I1A55_RS18900	COG1595	DNA-templated transcription, initiation
I1A55_RS18910	COG0753	catalase activity
I1A55_RS18915	COG0655	NAD(P)H dehydrogenase (quinone) activity
I1A55_RS18920	COG0400	carboxylic ester hydrolase activity
I1A55_RS18925	COG0346	lactoylglutathione lyase activity
I1A55_RS18930	COG1174	glycine betaine transport
I1A55_RS18935	COG0517	IMP dehydrogenase activity
I1A55_RS18935	COG1125	glycine betaine transport
I1A55_RS18940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I1A55_RS18945	COG0629	single-stranded DNA binding
I1A55_RS18950	COG0360	Binds together with S18 to 16S ribosomal RNA
I1A55_RS18955	COG0012	GTP binding
I1A55_RS18960	COG4481	Protein conserved in bacteria
I1A55_RS18975	COG3949	Membrane
I1A55_RS18985	COG1475	DNA binding
I1A55_RS18990	COG1192	Involved in chromosome partitioning
I1A55_RS19000	COG1475	DNA binding
I1A55_RS19005	COG0357	Ribosomal RNA small subunit methyltransferase G
I1A55_RS19010	COG0445	tRNA wobble uridine modification
I1A55_RS19015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I1A55_RS19020	COG1847	R3H domain protein
I1A55_RS19025	COG0706	membrane insertase activity
I1A55_RS19030	COG0594	ribonuclease P activity
I1A55_RS19035	COG0230	Belongs to the bacterial ribosomal protein bL34 family