locus-tag	class	description
NC3_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NC3_RS00010	COG0592	DNA-directed DNA polymerase activity
NC3_RS00015	COG2501	S4 domain
NC3_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NC3_RS00030	COG0187	DNA topoisomerase II activity
NC3_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NC3_RS00070	COG0516	GMP reductase activity
NC3_RS00070	COG0517	IMP dehydrogenase activity
NC3_RS00075	COG1686	Belongs to the peptidase S11 family
NC3_RS00080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NC3_RS00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NC3_RS00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NC3_RS00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NC3_RS00110	COG1428	Deoxynucleoside kinase
NC3_RS00115	COG1428	Deoxynucleoside kinase
NC3_RS00120	COG1388	LysM domain
NC3_RS00120	COG3858	chitin binding
NC3_RS00125	COG1335	isochorismatase
NC3_RS00130	COG0590	tRNA wobble adenosine to inosine editing
NC3_RS00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NC3_RS00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NC3_RS00150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NC3_RS00195	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
NC3_RS00200	COG3853	Toxic anion resistance protein (TelA)
NC3_RS00205	COG1982	Orn Lys Arg decarboxylase major
NC3_RS00210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NC3_RS00215	COG3870	Protein conserved in bacteria
NC3_RS00220	COG1728	Protein conserved in bacteria
NC3_RS00225	COG0470	DNA polymerase III
NC3_RS00230	COG1774	PSP1 C-terminal conserved region
NC3_RS00235	COG4467	Involved in initiation control of chromosome replication
NC3_RS00240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NC3_RS00245	COG2827	Endonuclease containing a URI domain
NC3_RS00250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NC3_RS00255	COG2002	toxin-antitoxin pair type II binding
NC3_RS00260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NC3_RS00260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NC3_RS00265	COG0084	hydrolase, TatD family'
NC3_RS00270	COG3583	domain protein
NC3_RS00270	COG3584	3D domain protein
NC3_RS00275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NC3_RS00280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NC3_RS00290	COG4466	Protein conserved in bacteria
NC3_RS00300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NC3_RS00305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NC3_RS00310	COG0251	oxidation-reduction process
NC3_RS00315	COG2088	sporulation resulting in formation of a cellular spore
NC3_RS00325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NC3_RS00330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NC3_RS00335	COG0193	aminoacyl-tRNA hydrolase activity
NC3_RS00345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NC3_RS00350	COG2002	toxin-antitoxin pair type II binding
NC3_RS00355	COG2244	polysaccharide biosynthetic process
NC3_RS00360	COG3956	TIGRFAM MazG family protein
NC3_RS00365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NC3_RS00380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NC3_RS00385	COG1098	S1 RNA binding domain
NC3_RS00400	COG2208	phosphoserine phosphatase activity
NC3_RS00405	COG2304	oxidoreductase activity
NC3_RS00410	COG0515	serine threonine protein kinase
NC3_RS00415	COG0037	tRNA processing
NC3_RS00420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NC3_RS00425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NC3_RS00430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NC3_RS00435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NC3_RS00440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NC3_RS00445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NC3_RS00450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NC3_RS00455	COG0512	Glutamine amidotransferase of anthranilate synthase
NC3_RS00460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NC3_RS00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NC3_RS00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NC3_RS00475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NC3_RS00480	COG1396	sequence-specific DNA binding
NC3_RS00485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NC3_RS00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NC3_RS00570	COG4463	regulation of RNA biosynthetic process
NC3_RS00575	COG3880	PFAM UvrB UvrC protein
NC3_RS00580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
NC3_RS00585	COG0542	response to heat
NC3_RS00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NC3_RS00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NC3_RS00600	COG4956	integral membrane protein (PIN domain superfamily)
NC3_RS00605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NC3_RS00610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NC3_RS00615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NC3_RS00620	COG1045	serine acetyltransferase
NC3_RS00625	COG0215	cysteine-tRNA ligase activity
NC3_RS00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NC3_RS00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NC3_RS00640	COG3688	RNA-binding protein containing a PIN domain
NC3_RS00645	COG1595	DNA-templated transcription, initiation
NC3_RS00650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NC3_RS00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NC3_RS00660	COG0250	Participates in transcription elongation, termination and antitermination
NC3_RS00670	COG0081	regulation of translation
NC3_RS00675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NC3_RS00680	COG0222	ribosome binding
NC3_RS00685	COG2813	Specifically methylates the guanine in position
NC3_RS00690	COG0085	RNA polymerase activity
NC3_RS00695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NC3_RS00700	COG1358	cellular component organization or biogenesis
NC3_RS00705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NC3_RS00710	COG0049	tRNA binding
NC3_RS00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NC3_RS00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NC3_RS00725	COG0596	Alpha beta hydrolase
NC3_RS00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NC3_RS00740	COG0088	Forms part of the polypeptide exit tunnel
NC3_RS00745	COG0089	rRNA binding
NC3_RS00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NC3_RS00755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NC3_RS00760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NC3_RS00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NC3_RS00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NC3_RS00775	COG0255	Belongs to the universal ribosomal protein uL29 family
NC3_RS00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NC3_RS00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NC3_RS00790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NC3_RS00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NC3_RS00800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NC3_RS00805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NC3_RS00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NC3_RS00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NC3_RS00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NC3_RS00825	COG1841	ribosomal large subunit assembly
NC3_RS00830	COG0200	Binds to the 23S rRNA
NC3_RS00835	COG0201	protein transport
NC3_RS00840	COG0563	adenylate kinase activity
NC3_RS00845	COG0024	Methionine aminopeptidase
NC3_RS00855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NC3_RS00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NC3_RS00865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NC3_RS00870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NC3_RS00875	COG0202	RNA polymerase activity
NC3_RS00880	COG0203	ribosomal protein L17
NC3_RS00885	COG1122	ATPase activity
NC3_RS00890	COG1122	ATPase activity
NC3_RS00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NC3_RS00900	COG0101	tRNA pseudouridine synthase activity
NC3_RS00905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NC3_RS00910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NC3_RS00935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NC3_RS00965	COG0860	N-Acetylmuramoyl-L-alanine amidase
NC3_RS00970	COG0489	protein tyrosine kinase activity
NC3_RS00980	COG2194	sulfuric ester hydrolase activity
NC3_RS00985	COG0726	polysaccharide deacetylase
NC3_RS01015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NC3_RS01020	COG0659	secondary active sulfate transmembrane transporter activity
NC3_RS01025	COG0385	Bile acid
NC3_RS01030	COG3876	Protein conserved in bacteria
NC3_RS01035	COG1472	Belongs to the glycosyl hydrolase 3 family
NC3_RS01040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NC3_RS01045	COG1263	PTS System
NC3_RS01045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC3_RS01050	COG1737	Transcriptional regulator
NC3_RS01055	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NC3_RS01090	COG1595	DNA-templated transcription, initiation
NC3_RS01095	COG5662	AntiSigma factor
NC3_RS01100	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NC3_RS01105	COG4856	YbbR-like protein
NC3_RS01110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NC3_RS01115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NC3_RS01150	COG1131	(ABC) transporter
NC3_RS01160	COG1136	(ABC) transporter
NC3_RS01170	COG1695	Transcriptional regulator
NC3_RS01180	COG1131	(ABC) transporter
NC3_RS01190	COG1413	lyase activity
NC3_RS01195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NC3_RS01205	COG2311	Membrane
NC3_RS01225	COG1476	TRANSCRIPTIONal
NC3_RS01235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NC3_RS01240	COG2207	Transcriptional regulator
NC3_RS01245	COG1309	transcriptional regulator
NC3_RS01260	COG1113	amino acid transport
NC3_RS01265	COG0584	glycerophosphoryl diester phosphodiesterase
NC3_RS01270	COG2271	Major facilitator Superfamily
NC3_RS01280	COG1331	Highly conserved protein containing a thioredoxin domain
NC3_RS01295	COG0640	Transcriptional regulator
NC3_RS01310	COG1937	Protein conserved in bacteria
NC3_RS01315	COG2210	Belongs to the sulfur carrier protein TusA family
NC3_RS01325	COG0425	Belongs to the sulfur carrier protein TusA family
NC3_RS01325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NC3_RS01330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NC3_RS01330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NC3_RS01335	COG0425	Belongs to the sulfur carrier protein TusA family
NC3_RS01340	COG0730	response to heat
NC3_RS01350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NC3_RS01355	COG2814	Major facilitator Superfamily
NC3_RS01370	COG1846	Transcriptional regulator
NC3_RS01375	COG1683	Conserved Protein
NC3_RS01385	COG0656	L-ascorbic acid biosynthetic process
NC3_RS01390	COG0371	Dehydrogenase
NC3_RS01395	COG1054	Belongs to the UPF0176 family
NC3_RS01400	COG0531	amino acid
NC3_RS01410	COG3711	transcriptional antiterminator
NC3_RS01415	COG2190	(PTS) system
NC3_RS01415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC3_RS01415	COG1263	PTS System
NC3_RS01420	COG2723	6-phospho-beta-galactosidase activity
NC3_RS01435	COG3711	transcriptional antiterminator
NC3_RS01435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC3_RS01440	COG1940	carbohydrate kinase activity
NC3_RS01445	COG0383	alpha-mannosidase activity
NC3_RS01450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NC3_RS01455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NC3_RS01465	COG1404	Belongs to the peptidase S8 family
NC3_RS01480	COG0833	amino acid
NC3_RS01485	COG2040	homocysteine
NC3_RS01490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NC3_RS01495	COG1695	Transcriptional regulator
NC3_RS01510	COG2814	Major facilitator Superfamily
NC3_RS01515	COG0456	acetyltransferase
NC3_RS01530	COG1404	Belongs to the peptidase S8 family
NC3_RS01540	COG1309	transcriptional regulator
NC3_RS01545	COG1917	Cupin 2, conserved barrel domain protein
NC3_RS01550	COG1063	alcohol dehydrogenase
NC3_RS01555	COG1846	Transcriptional regulator
NC3_RS01560	COG0318	PFAM AMP-dependent synthetase and ligase
NC3_RS01565	COG0531	amino acid
NC3_RS01575	COG0596	Alpha beta hydrolase
NC3_RS01580	COG1115	amino acid carrier protein
NC3_RS01585	COG2066	Belongs to the glutaminase family
NC3_RS01590	COG4191	Histidine kinase
NC3_RS01595	COG0784	Response regulator, receiver
NC3_RS01600	COG3012	SEC-C Motif Domain Protein
NC3_RS01600	COG1405	negative regulation of cell septum assembly
NC3_RS01610	COG0667	Aldo Keto reductase
NC3_RS01615	COG3290	protein histidine kinase activity
NC3_RS01620	COG3279	Response regulator of the LytR AlgR family
NC3_RS01625	COG4555	ABC transporter
NC3_RS01630	COG1668	transmembrane transport
NC3_RS01645	COG3773	Cell wall hydrolase
NC3_RS01650	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS01660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NC3_RS01665	COG2310	stress, protein
NC3_RS01670	COG2310	stress, protein
NC3_RS01675	COG2310	stress, protein
NC3_RS01680	COG0861	Integral membrane protein TerC family
NC3_RS01710	COG3853	Toxic anion resistance protein (TelA)
NC3_RS01715	COG0517	IMP dehydrogenase activity
NC3_RS01715	COG4175	Glycine betaine
NC3_RS01720	COG4176	ABC-type proline glycine betaine transport system permease component
NC3_RS01725	COG2113	Glycine betaine
NC3_RS01740	COG1473	amidohydrolase
NC3_RS01745	COG1288	antiporter activity
NC3_RS01750	COG0039	L-malate dehydrogenase activity
NC3_RS01755	COG1620	l-lactate permease
NC3_RS01760	COG1609	Transcriptional regulator
NC3_RS01765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NC3_RS01770	COG0561	phosphatase activity
NC3_RS01775	COG0673	inositol 2-dehydrogenase activity
NC3_RS01780	COG0738	Major facilitator superfamily
NC3_RS01785	COG1280	lysine exporter protein (LysE YggA)
NC3_RS01800	COG3403	YqcI/YcgG family
NC3_RS01805	COG1113	amino acid transport
NC3_RS01810	COG3665	Urea carboxylase-associated protein
NC3_RS01815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NC3_RS01825	COG1012	belongs to the aldehyde dehydrogenase family
NC3_RS01830	COG0710	3-dehydroquinate dehydratase activity
NC3_RS01835	COG0028	Belongs to the TPP enzyme family
NC3_RS01845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NC3_RS01850	COG2271	Major facilitator Superfamily
NC3_RS01865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NC3_RS01870	COG2226	methyltransferase
NC3_RS01875	COG0583	DNA-binding transcription factor activity
NC3_RS01880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NC3_RS01885	COG3458	cephalosporin-C deacetylase activity
NC3_RS01895	COG3541	Predicted nucleotidyltransferase
NC3_RS01900	COG0506	proline dehydrogenase activity
NC3_RS01905	COG1012	belongs to the aldehyde dehydrogenase family
NC3_RS01910	COG2508	Transcriptional regulator
NC3_RS01915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NC3_RS01920	COG0765	amino acid transport
NC3_RS01925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC3_RS01935	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NC3_RS01940	COG1522	sequence-specific DNA binding
NC3_RS01945	COG2746	aminoglycoside 3-N-acetyltransferase activity
NC3_RS01955	COG3290	protein histidine kinase activity
NC3_RS01955	COG0840	transmembrane signaling receptor activity
NC3_RS01960	COG3209	COG3209 Rhs family protein
NC3_RS01980	COG3842	ATPase activity
NC3_RS01985	COG1176	ABC-type spermidine putrescine transport system, permease component I
NC3_RS01995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NC3_RS02000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NC3_RS02005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NC3_RS02020	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NC3_RS02025	COG4555	ABC transporter
NC3_RS02035	COG0697	spore germination
NC3_RS02040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NC3_RS02050	COG2207	Transcriptional regulator
NC3_RS02050	COG3708	Transcriptional regulator
NC3_RS02060	COG2364	Membrane
NC3_RS02065	COG1126	abc transporter atp-binding protein
NC3_RS02070	COG0765	amino acid transport
NC3_RS02075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC3_RS02080	COG0412	Dienelactone hydrolase
NC3_RS02085	COG0833	amino acid
NC3_RS02090	COG3104	oligopeptide transport
NC3_RS02095	COG5434	Belongs to the glycosyl hydrolase 28 family
NC3_RS02100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NC3_RS02105	COG0456	acetyltransferase
NC3_RS02110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC3_RS02115	COG0765	amino acid transport
NC3_RS02120	COG1126	abc transporter atp-binding protein
NC3_RS02125	COG1473	amidohydrolase
NC3_RS02130	COG2079	MmgE PrpD family protein
NC3_RS02135	COG0745	RESPONSE REGULATOR receiver
NC3_RS02140	COG3850	Histidine kinase
NC3_RS02140	COG5002	protein histidine kinase activity
NC3_RS02145	COG1366	Belongs to the anti-sigma-factor antagonist family
NC3_RS02150	COG0527	aspartate kinase activity
NC3_RS02155	COG2814	Major facilitator Superfamily
NC3_RS02160	COG1309	transcriptional regulator
NC3_RS02170	COG0640	Transcriptional regulator
NC3_RS02180	COG0583	DNA-binding transcription factor activity
NC3_RS02185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NC3_RS02190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NC3_RS02195	COG0531	amino acid
NC3_RS02200	COG1012	belongs to the aldehyde dehydrogenase family
NC3_RS02205	COG2249	NAD(P)H dehydrogenase (quinone) activity
NC3_RS02210	COG4549	nuclear export factor GLE1
NC3_RS02215	COG2372	response to copper ion
NC3_RS02215	COG1276	copper resistance
NC3_RS02220	COG2213	PTS system mannitol-specific
NC3_RS02225	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC3_RS02230	COG0246	Mannitol dehydrogenase
NC3_RS02235	COG0840	transmembrane signaling receptor activity
NC3_RS02270	COG0346	lactoylglutathione lyase activity
NC3_RS02280	COG0561	phosphatase activity
NC3_RS02285	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NC3_RS02290	COG1914	H( )-stimulated, divalent metal cation uptake system
NC3_RS02295	COG4336	lyase activity
NC3_RS02300	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NC3_RS02305	COG1984	allophanate hydrolase subunit 2
NC3_RS02310	COG1414	Transcriptional regulator
NC3_RS02315	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NC3_RS02320	COG2755	lipolytic protein G-D-S-L family
NC3_RS02330	COG3711	transcriptional antiterminator
NC3_RS02335	COG2226	methyltransferase
NC3_RS02340	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS02345	COG3871	stress protein (general stress protein 26)
NC3_RS02365	COG2814	Major facilitator Superfamily
NC3_RS02370	COG1802	Transcriptional regulator
NC3_RS02375	COG1917	Cupin 2, conserved barrel domain protein
NC3_RS02375	COG2207	Transcriptional regulator
NC3_RS02380	COG0697	spore germination
NC3_RS02385	COG0473	3-isopropylmalate dehydrogenase activity
NC3_RS02390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NC3_RS02390	COG0551	DNA topoisomerase type I activity
NC3_RS02395	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
NC3_RS02400	COG3706	GGDEF domain
NC3_RS02405	COG5298	Protein conserved in bacteria
NC3_RS02410	COG1215	transferase activity, transferring glycosyl groups
NC3_RS02420	COG0531	amino acid
NC3_RS02425	COG0028	Belongs to the TPP enzyme family
NC3_RS02430	COG5444	nuclease activity
NC3_RS02450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NC3_RS02455	COG1914	H( )-stimulated, divalent metal cation uptake system
NC3_RS02460	COG2261	transglycosylase associated protein
NC3_RS02465	COG2217	Heavy metal translocating P-type atpase
NC3_RS02470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NC3_RS02475	COG3290	protein histidine kinase activity
NC3_RS02480	COG4565	transcriptional regulatory protein
NC3_RS02485	COG1301	dicarboxylic acid transport
NC3_RS02490	COG0628	permease
NC3_RS02495	COG1301	dicarboxylic acid transport
NC3_RS02500	COG1131	(ABC) transporter
NC3_RS02505	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NC3_RS02520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NC3_RS02525	COG1181	Belongs to the D-alanine--D-alanine ligase family
NC3_RS02530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NC3_RS02545	COG0513	Belongs to the DEAD box helicase family
NC3_RS02550	COG3402	PFAM membrane-flanked domain
NC3_RS02555	COG3428	Bacterial PH domain
NC3_RS02560	COG0705	Rhomboid family
NC3_RS02565	COG0736	holo-[acyl-carrier-protein] synthase activity
NC3_RS02570	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NC3_RS02575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NC3_RS02580	COG0864	Transcriptional regulator
NC3_RS02585	COG2337	Toxic component of a toxin-antitoxin (TA) module
NC3_RS02590	COG1366	Belongs to the anti-sigma-factor antagonist family
NC3_RS02595	COG1366	Belongs to the anti-sigma-factor antagonist family
NC3_RS02600	COG2172	sigma factor antagonist activity
NC3_RS02605	COG2208	phosphoserine phosphatase activity
NC3_RS02610	COG1366	Belongs to the anti-sigma-factor antagonist family
NC3_RS02615	COG2172	sigma factor antagonist activity
NC3_RS02620	COG1191	sigma factor activity
NC3_RS02625	COG2208	phosphoserine phosphatase activity
NC3_RS02630	COG2183	response to ionizing radiation
NC3_RS02640	COG3091	SprT-like family
NC3_RS02645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NC3_RS02650	COG0022	dehydrogenase e1 component
NC3_RS02655	COG0508	dehydrogenase complex catalyzes the overall conversion of
NC3_RS02660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NC3_RS02665	COG3284	Transcriptional regulator
NC3_RS02710	COG5644	endopeptidase inhibitor activity
NC3_RS02735	COG1278	Cold shock
NC3_RS02740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC3_RS02740	COG1263	PTS System
NC3_RS02740	COG2190	(PTS) system
NC3_RS02745	COG3394	polysaccharide catabolic process
NC3_RS02750	COG3711	transcriptional antiterminator
NC3_RS02755	COG1064	alcohol dehydrogenase
NC3_RS02760	COG0789	Transcriptional regulator
NC3_RS02780	COG0477	Major facilitator Superfamily
NC3_RS02785	COG0657	acetylesterase activity
NC3_RS02795	COG4221	oxidoreductase activity
NC3_RS02805	COG0252	asparaginase activity
NC3_RS02810	COG2267	carboxylic ester hydrolase activity
NC3_RS02830	COG2814	Major facilitator Superfamily
NC3_RS02845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NC3_RS02875	COG1309	transcriptional regulator
NC3_RS02880	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NC3_RS02885	COG1846	Transcriptional regulator
NC3_RS02890	COG0778	Nitroreductase
NC3_RS02905	COG1396	sequence-specific DNA binding
NC3_RS02915	COG0456	acetyltransferase
NC3_RS02925	COG4122	O-methyltransferase activity
NC3_RS02935	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NC3_RS02940	COG0697	spore germination
NC3_RS02950	COG1301	dicarboxylic acid transport
NC3_RS02990	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NC3_RS02995	COG0802	atpase or kinase
NC3_RS03000	COG1214	PFAM Peptidase M22, glycoprotease
NC3_RS03005	COG0456	acetyltransferase
NC3_RS03010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NC3_RS03015	COG0488	(ABC) transporter
NC3_RS03020	COG0315	cyclic pyranopterin monophosphate synthase activity
NC3_RS03025	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NC3_RS03030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NC3_RS03035	COG0805	protein transport
NC3_RS03050	COG1266	CAAX protease self-immunity
NC3_RS03055	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NC3_RS03060	COG0459	protein refolding
NC3_RS03065	COG1846	Transcriptional regulator
NC3_RS03070	COG2808	Putative FMN-binding domain
NC3_RS03075	COG1876	peptidase activity
NC3_RS03100	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NC3_RS03105	COG0823	Involved in the tonB-independent uptake of proteins
NC3_RS03115	COG2132	Multicopper oxidase
NC3_RS03120	COG1113	amino acid transport
NC3_RS03125	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NC3_RS03130	COG0714	Associated with various cellular activities
NC3_RS03135	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
NC3_RS03140	COG1305	Transglutaminase-like
NC3_RS03145	COG0519	Catalyzes the synthesis of GMP from XMP
NC3_RS03145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NC3_RS03150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NC3_RS03160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NC3_RS03165	COG2207	Transcriptional regulator
NC3_RS03180	COG0326	Molecular chaperone. Has ATPase activity
NC3_RS03205	COG1595	DNA-templated transcription, initiation
NC3_RS03220	COG2814	Major facilitator Superfamily
NC3_RS03225	COG0583	DNA-binding transcription factor activity
NC3_RS03230	COG2252	PERMEase
NC3_RS03240	COG5583	Uncharacterized small protein (DUF2292)
NC3_RS03245	COG3064	Membrane
NC3_RS03250	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
NC3_RS03260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NC3_RS03265	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NC3_RS03270	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NC3_RS03275	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NC3_RS03280	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NC3_RS03285	COG0047	phosphoribosylformylglycinamidine synthase activity
NC3_RS03290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NC3_RS03295	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NC3_RS03300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NC3_RS03305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NC3_RS03310	COG0138	bifunctional purine biosynthesis protein purh
NC3_RS03315	COG0151	Belongs to the GarS family
NC3_RS03335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NC3_RS03340	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NC3_RS03345	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NC3_RS03350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NC3_RS03360	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NC3_RS03365	COG4496	protein, YerC YecD
NC3_RS03380	COG0069	glutamate synthase activity
NC3_RS03395	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
NC3_RS03400	COG0210	DNA helicase
NC3_RS03405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NC3_RS03410	COG4851	CamS sex pheromone cAM373 precursor
NC3_RS03415	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NC3_RS03420	COG1285	pathogenesis
NC3_RS03425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NC3_RS03430	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NC3_RS03435	COG0154	amidase activity
NC3_RS03440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NC3_RS03445	COG1309	transcriptional regulator
NC3_RS03450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NC3_RS03455	COG1957	nucleoside hydrolase
NC3_RS03460	COG1597	lipid kinase activity
NC3_RS03465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NC3_RS03470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NC3_RS03485	COG1959	2 iron, 2 sulfur cluster binding
NC3_RS03490	COG0492	ferredoxin-NADP+ reductase activity
NC3_RS03505	COG1486	melibiose metabolic process
NC3_RS03515	COG2211	Major facilitator Superfamily
NC3_RS03545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NC3_RS03550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NC3_RS03555	COG1442	glycosyl transferase family 8
NC3_RS03560	COG1216	Glycosyl transferase, family 2
NC3_RS03565	COG1442	glycosyl transferase family 8
NC3_RS03570	COG2223	nitrite transmembrane transporter activity
NC3_RS03580	COG0471	metal ion transport
NC3_RS03595	COG0071	Belongs to the small heat shock protein (HSP20) family
NC3_RS03610	COG0531	amino acid
NC3_RS03615	COG0457	Tetratricopeptide repeat
NC3_RS03615	COG0463	Glycosyl transferase, family 2
NC3_RS03620	COG0488	(ABC) transporter
NC3_RS03625	COG1469	GTP cyclohydrolase I activity
NC3_RS03630	COG0789	Transcriptional regulator
NC3_RS03635	COG2814	Major facilitator Superfamily
NC3_RS03640	COG0488	(ABC) transporter
NC3_RS03645	COG0513	Belongs to the DEAD box helicase family
NC3_RS03650	COG2130	NADP-dependent
NC3_RS03670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NC3_RS03670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NC3_RS03675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NC3_RS03685	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NC3_RS03685	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NC3_RS03695	COG3290	protein histidine kinase activity
NC3_RS03700	COG4565	transcriptional regulatory protein
NC3_RS03705	COG3181	Tripartite tricarboxylate transporter family receptor
NC3_RS03710	COG2851	Citrate transporter
NC3_RS03720	COG3479	Phenolic acid decarboxylase
NC3_RS03725	COG1695	Transcriptional regulator
NC3_RS03730	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
NC3_RS03740	COG1254	Belongs to the acylphosphatase family
NC3_RS03745	COG2258	MOSC domain
NC3_RS03760	COG0024	Methionine aminopeptidase
NC3_RS03765	COG1263	PTS System
NC3_RS03765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC3_RS03770	COG3739	integral membrane protein
NC3_RS03790	COG1368	sulfuric ester hydrolase activity
NC3_RS03795	COG0076	glutamate decarboxylase activity
NC3_RS03810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC3_RS03810	COG1263	PTS System
NC3_RS03815	COG0366	Alpha amylase catalytic
NC3_RS03820	COG2188	Transcriptional regulator
NC3_RS03830	COG0737	Belongs to the 5'-nucleotidase family
NC3_RS03835	COG0693	protein deglycase activity
NC3_RS03840	COG4840	Belongs to the UPF0435 family
NC3_RS03845	COG1115	amino acid carrier protein
NC3_RS03850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NC3_RS03855	COG4980	gas vesicle protein
NC3_RS03860	COG1295	ribonuclease BN
NC3_RS03865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NC3_RS03870	COG0477	Major facilitator Superfamily
NC3_RS03880	COG0387	Pfam Sodium calcium exchanger
NC3_RS03890	COG0217	transcriptional regulatory protein
NC3_RS03900	COG0668	transmembrane transport
NC3_RS03905	COG0535	radical SAM domain protein
NC3_RS03915	COG0726	polysaccharide deacetylase
NC3_RS03925	COG0598	Magnesium transport protein CorA
NC3_RS03935	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NC3_RS03940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NC3_RS03955	COG0583	DNA-binding transcription factor activity
NC3_RS03960	COG1942	4-Oxalocrotonate Tautomerase
NC3_RS03965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NC3_RS03970	COG0789	Transcriptional regulator
NC3_RS03975	COG2814	Major facilitator Superfamily
NC3_RS03990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NC3_RS04040	COG2076	Multidrug Resistance protein
NC3_RS04045	COG2076	Multidrug Resistance protein
NC3_RS04050	COG1309	transcriptional regulator
NC3_RS04060	COG4637	Psort location Cytoplasmic, score
NC3_RS04065	COG2755	lipolytic protein G-D-S-L family
NC3_RS04070	COG0492	ferredoxin-NADP+ reductase activity
NC3_RS04075	COG2169	Transcriptional regulator
NC3_RS04080	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NC3_RS04085	COG1132	(ABC) transporter
NC3_RS04090	COG1742	UPF0060 membrane protein
NC3_RS04095	COG1595	DNA-templated transcription, initiation
NC3_RS04115	COG2318	DinB family
NC3_RS04125	COG1846	Transcriptional regulator
NC3_RS04130	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NC3_RS04130	COG0392	lysyltransferase activity
NC3_RS04150	COG0778	Nitroreductase
NC3_RS04165	COG1090	epimerase
NC3_RS04170	COG2137	regulation of response to DNA damage stimulus
NC3_RS04195	COG0463	Glycosyl transferase, family 2
NC3_RS04200	COG4485	Bacterial membrane protein, YfhO
NC3_RS04205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NC3_RS04220	COG2140	Oxalate decarboxylase
NC3_RS04230	COG1191	sigma factor activity
NC3_RS04240	COG1988	membrane-bound metal-dependent
NC3_RS04245	COG1194	a g-specific adenine glycosylase
NC3_RS04255	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS04270	COG3557	Belongs to the UPF0374 family
NC3_RS04275	COG1132	(ABC) transporter
NC3_RS04280	COG0444	Belongs to the ABC transporter superfamily
NC3_RS04285	COG4608	Belongs to the ABC transporter superfamily
NC3_RS04290	COG0747	negative chemotaxis
NC3_RS04295	COG0601	transmembrane transport
NC3_RS04300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC3_RS04305	COG4129	membrane
NC3_RS04310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NC3_RS04315	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NC3_RS04320	COG0735	belongs to the Fur family
NC3_RS04470	COG1368	sulfuric ester hydrolase activity
NC3_RS04475	COG0681	Belongs to the peptidase S26 family
NC3_RS04480	COG2873	o-acetylhomoserine
NC3_RS04490	COG1116	anion transmembrane transporter activity
NC3_RS04495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NC3_RS04500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NC3_RS04505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NC3_RS04515	COG1131	(ABC) transporter
NC3_RS04545	COG3382	B3 4 domain protein
NC3_RS04550	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NC3_RS04560	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NC3_RS04565	COG2766	serine protein kinase
NC3_RS04570	COG2718	Belongs to the UPF0229 family
NC3_RS04575	COG1566	PFAM secretion protein HlyD family protein
NC3_RS04580	COG2814	Major facilitator Superfamily
NC3_RS04585	COG0655	NAD(P)H dehydrogenase (quinone) activity
NC3_RS04595	COG1278	Cold shock
NC3_RS04600	COG3706	GGDEF domain
NC3_RS04625	COG5577	PFAM Coat F domain
NC3_RS04630	COG5002	protein histidine kinase activity
NC3_RS04635	COG0737	Belongs to the 5'-nucleotidase family
NC3_RS04635	COG1525	nuclease
NC3_RS04635	COG4085	toxin activity
NC3_RS04640	COG3764	Sortase (surface protein transpeptidase)
NC3_RS04645	COG0564	pseudouridine synthase activity
NC3_RS04655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NC3_RS04660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NC3_RS04660	COG3153	acetyltransferase
NC3_RS04680	COG3835	regulator
NC3_RS04685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NC3_RS04690	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
NC3_RS04695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NC3_RS04700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NC3_RS04705	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NC3_RS04710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NC3_RS04715	COG2203	Gaf domain
NC3_RS04715	COG4585	Histidine kinase
NC3_RS04720	COG2197	response regulator
NC3_RS04740	COG0753	catalase activity
NC3_RS04745	COG1959	2 iron, 2 sulfur cluster binding
NC3_RS04750	COG1017	nitric oxide dioxygenase activity
NC3_RS04750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NC3_RS04755	COG2719	SpoVR family
NC3_RS04760	COG1785	Belongs to the alkaline phosphatase family
NC3_RS04765	COG0791	NLP P60 protein
NC3_RS04765	COG1388	LysM domain
NC3_RS04770	COG0531	amino acid
NC3_RS04785	COG1595	DNA-templated transcription, initiation
NC3_RS04790	COG0204	Acyl-transferase
NC3_RS04795	COG1253	flavin adenine dinucleotide binding
NC3_RS04800	COG0789	Transcriptional regulator
NC3_RS04805	COG1253	flavin adenine dinucleotide binding
NC3_RS04820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NC3_RS04825	COG0584	glycerophosphoryl diester phosphodiesterase
NC3_RS04835	COG0668	transmembrane transport
NC3_RS04840	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NC3_RS04845	COG0726	polysaccharide deacetylase
NC3_RS04850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NC3_RS04855	COG0589	response to stress
NC3_RS04860	COG1132	(ABC) transporter
NC3_RS04865	COG1132	(ABC) transporter
NC3_RS04870	COG0702	epimerase
NC3_RS04880	COG3842	ATPase activity
NC3_RS04885	COG2508	Transcriptional regulator
NC3_RS04895	COG0189	ligase activity
NC3_RS04900	COG0189	ligase activity
NC3_RS04905	COG4399	Belongs to the UPF0754 family
NC3_RS04910	COG3679	Belongs to the UPF0342 family
NC3_RS04915	COG0561	phosphatase activity
NC3_RS04920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NC3_RS04930	COG0475	glutathione-regulated potassium exporter activity
NC3_RS04935	COG0490	domain, Protein
NC3_RS04945	COG1024	Enoyl-CoA hydratase
NC3_RS04955	COG0420	3'-5' exonuclease activity
NC3_RS04960	COG4717	serine-type aminopeptidase activity
NC3_RS04965	COG3481	metal-dependent phosphohydrolase, HD sub domain
NC3_RS04975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NC3_RS05005	COG1846	Transcriptional regulator
NC3_RS05010	COG4980	gas vesicle protein
NC3_RS05025	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NC3_RS05030	COG0537	adenosine 5'-monophosphoramidase activity
NC3_RS05035	COG1131	(ABC) transporter
NC3_RS05040	COG4473	ABC transporter
NC3_RS05050	COG1473	amidohydrolase
NC3_RS05060	COG2329	Antibiotic biosynthesis monooxygenase
NC3_RS05065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NC3_RS05070	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NC3_RS05075	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NC3_RS05080	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NC3_RS05085	COG1309	transcriptional regulator
NC3_RS05090	COG1511	domain protein
NC3_RS05095	COG1363	Peptidase, m42
NC3_RS05100	COG1301	dicarboxylic acid transport
NC3_RS05110	COG1234	tRNA 3'-trailer cleavage
NC3_RS05115	COG0095	Lipoate-protein ligase
NC3_RS05120	COG0318	PFAM AMP-dependent synthetase and ligase
NC3_RS05130	COG0501	Belongs to the peptidase M48B family
NC3_RS05135	COG1404	Belongs to the peptidase S8 family
NC3_RS05140	COG0406	alpha-ribazole phosphatase activity
NC3_RS05145	COG0840	transmembrane signaling receptor activity
NC3_RS05150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NC3_RS05150	COG0723	plastoquinol--plastocyanin reductase activity
NC3_RS05155	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS05165	COG4903	ComK protein
NC3_RS05180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NC3_RS05185	COG2814	Major facilitator Superfamily
NC3_RS05190	COG2732	(Barnase) inhibitor
NC3_RS05195	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC3_RS05200	COG4605	iron ion homeostasis
NC3_RS05205	COG4604	ABC transporter, ATP-binding protein
NC3_RS05210	COG4607	ABC-type enterochelin transport system periplasmic component
NC3_RS05215	COG1316	TRANSCRIPTIONal
NC3_RS05230	COG0398	Pfam SNARE associated Golgi protein
NC3_RS05235	COG0681	Belongs to the peptidase S26 family
NC3_RS05240	COG3180	Ammonia monooxygenase
NC3_RS05255	COG2259	Doxx family
NC3_RS05260	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NC3_RS05265	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
NC3_RS05270	COG1074	ATP-dependent DNA helicase activity
NC3_RS05275	COG0420	3'-5' exonuclease activity
NC3_RS05280	COG0419	ATPase involved in DNA repair
NC3_RS05285	COG1403	HNH endonuclease
NC3_RS05325	COG5337	Spore coat protein CotH
NC3_RS05340	COG0179	Fumarylacetoacetate (FAA) hydrolase
NC3_RS05355	COG0367	asparagine synthase
NC3_RS05370	COG1562	ergosterol biosynthetic process
NC3_RS05375	COG0534	Mate efflux family protein
NC3_RS05380	COG1917	Cupin 2, conserved barrel domain protein
NC3_RS05380	COG2207	Transcriptional regulator
NC3_RS05405	COG0076	glutamate decarboxylase activity
NC3_RS05440	COG0646	methionine synthase
NC3_RS05440	COG1410	methionine synthase
NC3_RS05445	COG0646	methionine synthase
NC3_RS05445	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NC3_RS05450	COG1666	GTP binding
NC3_RS05455	COG2996	Protein conserved in bacteria
NC3_RS05460	COG1744	ABC transporter substrate-binding protein PnrA-like
NC3_RS05465	COG0840	transmembrane signaling receptor activity
NC3_RS05470	COG1307	EDD domain protein, DegV family
NC3_RS05475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NC3_RS05495	COG0561	phosphatase activity
NC3_RS05500	COG1073	alpha beta
NC3_RS05505	COG2151	metal-sulfur cluster biosynthetic enzyme
NC3_RS05510	COG0277	FAD linked oxidase domain protein
NC3_RS05515	COG2271	Major facilitator Superfamily
NC3_RS05520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NC3_RS05525	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NC3_RS05530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NC3_RS05535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NC3_RS05540	COG0505	Belongs to the CarA family
NC3_RS05545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NC3_RS05550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NC3_RS05560	COG2814	Major facilitator Superfamily
NC3_RS05570	COG2267	carboxylic ester hydrolase activity
NC3_RS05580	COG1744	ABC transporter substrate-binding protein PnrA-like
NC3_RS05595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NC3_RS05600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NC3_RS05605	COG5504	Zn-dependent protease
NC3_RS05610	COG0444	Belongs to the ABC transporter superfamily
NC3_RS05615	COG4608	Belongs to the ABC transporter superfamily
NC3_RS05625	COG0601	transmembrane transport
NC3_RS05630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC3_RS05640	COG0180	Tryptophanyl-tRNA synthetase
NC3_RS05645	COG4166	transmembrane transport
NC3_RS05650	COG0601	transmembrane transport
NC3_RS05655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC3_RS05660	COG0444	Belongs to the ABC transporter superfamily
NC3_RS05665	COG4608	Belongs to the ABC transporter superfamily
NC3_RS05675	COG0456	acetyltransferase
NC3_RS05680	COG1393	Belongs to the ArsC family
NC3_RS05685	COG0861	Integral membrane protein TerC family
NC3_RS05690	COG4862	establishment of competence for transformation
NC3_RS05695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NC3_RS05705	COG1164	Oligoendopeptidase f
NC3_RS05715	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NC3_RS05720	COG2346	COG2346, Truncated hemoglobins
NC3_RS05725	COG0741	lytic transglycosylase activity
NC3_RS05730	COG4116	CYTH
NC3_RS05740	COG2357	RelA SpoT domain protein
NC3_RS05745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NC3_RS05750	COG0564	pseudouridine synthase activity
NC3_RS05755	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NC3_RS05760	COG0475	glutathione-regulated potassium exporter activity
NC3_RS05760	COG0569	domain protein
NC3_RS05765	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NC3_RS05770	COG0352	thiamine-phosphate diphosphorylase activity
NC3_RS05780	COG2104	thiamine diphosphate biosynthetic process
NC3_RS05785	COG2022	thiamine diphosphate biosynthetic process
NC3_RS05790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NC3_RS05795	COG0351	phosphomethylpyrimidine kinase
NC3_RS05800	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NC3_RS05855	COG0210	DNA helicase
NC3_RS05865	COG2153	protein acetylation
NC3_RS05870	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NC3_RS05875	COG2382	esterase
NC3_RS05880	COG0626	cystathionine gamma-synthase activity
NC3_RS05885	COG0626	cystathionine gamma-synthase activity
NC3_RS05955	COG0825	malonyl-CoA metabolic process
NC3_RS05970	COG0457	Tetratricopeptide repeat
NC3_RS05980	COG2153	protein acetylation
NC3_RS05985	COG2364	Membrane
NC3_RS06000	COG0300	oxidoreductase activity
NC3_RS06015	COG0583	DNA-binding transcription factor activity
NC3_RS06035	COG0583	DNA-binding transcription factor activity
NC3_RS06040	COG2807	transmembrane transport
NC3_RS06075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NC3_RS06085	COG1309	transcriptional regulator
NC3_RS06095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NC3_RS06100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NC3_RS06120	COG4195	phage-related replication protein
NC3_RS06125	COG2856	Zn peptidase
NC3_RS06130	COG3409	Peptidoglycan-binding domain 1 protein
NC3_RS06130	COG5632	N-Acetylmuramoyl-L-alanine amidase
NC3_RS06145	COG0306	phosphate transporter
NC3_RS06150	COG1392	Phosphate transport regulator
NC3_RS06160	COG0405	Gamma-glutamyltransferase
NC3_RS06165	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NC3_RS06175	COG4208	sulfate ABC transporter
NC3_RS06180	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NC3_RS06190	COG3775	system Galactitol-specific IIC component
NC3_RS06205	COG1063	alcohol dehydrogenase
NC3_RS06210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NC3_RS06215	COG0022	dehydrogenase e1 component
NC3_RS06215	COG0508	dehydrogenase complex catalyzes the overall conversion of
NC3_RS06220	COG0508	dehydrogenase complex catalyzes the overall conversion of
NC3_RS06225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NC3_RS06230	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS06235	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS06240	COG2390	Transcriptional regulator
NC3_RS06250	COG0531	amino acid
NC3_RS06255	COG0346	lactoylglutathione lyase activity
NC3_RS06260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NC3_RS06265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NC3_RS06270	COG2362	D-Aminopeptidase
NC3_RS06275	COG0601	transmembrane transport
NC3_RS06280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC3_RS06285	COG0444	Belongs to the ABC transporter superfamily
NC3_RS06290	COG4166	transmembrane transport
NC3_RS06295	COG1619	proteins homologs of microcin C7 resistance protein MccF
NC3_RS06300	COG4948	Mandelate Racemase Muconate Lactonizing
NC3_RS06305	COG0791	NLP P60 protein
NC3_RS06310	COG4608	Belongs to the ABC transporter superfamily
NC3_RS06315	COG1834	amidinotransferase
NC3_RS06320	COG1607	acyl-coa hydrolase
NC3_RS06325	COG1695	Transcriptional regulator
NC3_RS06340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NC3_RS06350	COG2076	Multidrug Resistance protein
NC3_RS06355	COG2076	Multidrug Resistance protein
NC3_RS06365	COG0788	formyltetrahydrofolate deformylase activity
NC3_RS06370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NC3_RS06375	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NC3_RS06380	COG0457	Tetratricopeptide repeat
NC3_RS06390	COG1764	response to oxidative stress
NC3_RS06395	COG1846	Transcriptional regulator
NC3_RS06400	COG1764	response to oxidative stress
NC3_RS06405	COG0590	tRNA wobble adenosine to inosine editing
NC3_RS06410	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NC3_RS06415	COG1404	Belongs to the peptidase S8 family
NC3_RS06430	COG0745	RESPONSE REGULATOR receiver
NC3_RS06435	COG3850	Histidine kinase
NC3_RS06435	COG5002	protein histidine kinase activity
NC3_RS06440	COG3212	peptidase
NC3_RS06445	COG3212	peptidase
NC3_RS06455	COG2239	Acts as a magnesium transporter
NC3_RS06465	COG0583	DNA-binding transcription factor activity
NC3_RS06475	COG0789	Transcriptional regulator
NC3_RS06490	COG1846	Transcriptional regulator
NC3_RS06495	COG3300	MHYT domain
NC3_RS06495	COG5001	Diguanylate cyclase
NC3_RS06500	COG0586	Pfam SNARE associated Golgi protein
NC3_RS06505	COG0861	Integral membrane protein TerC family
NC3_RS06510	COG1191	sigma factor activity
NC3_RS06530	COG0501	Belongs to the peptidase M48B family
NC3_RS06535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NC3_RS06540	COG2323	membrane
NC3_RS06555	COG3594	Acyltransferase
NC3_RS06560	COG5002	protein histidine kinase activity
NC3_RS06565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NC3_RS06570	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NC3_RS06575	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
NC3_RS06580	COG0436	Aminotransferase
NC3_RS06585	COG1850	ribulose-bisphosphate carboxylase activity
NC3_RS06590	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
NC3_RS06595	COG0235	Class ii aldolase
NC3_RS06600	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NC3_RS06610	COG3852	Histidine kinase
NC3_RS06615	COG1846	Transcriptional regulator
NC3_RS06620	COG1360	Flagellar Motor Protein
NC3_RS06625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NC3_RS06630	COG0542	response to heat
NC3_RS06635	COG3949	Membrane
NC3_RS06640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NC3_RS06645	COG0720	synthase
NC3_RS06650	COG0602	queuosine metabolic process
NC3_RS06655	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NC3_RS06660	COG1733	regulation of RNA biosynthetic process
NC3_RS06665	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS06675	COG4873	Protein conserved in bacteria
NC3_RS06685	COG3773	Cell wall hydrolase
NC3_RS06690	COG2244	polysaccharide biosynthetic process
NC3_RS06695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NC3_RS06700	COG2217	Heavy metal translocating P-type atpase
NC3_RS06705	COG0006	proline dipeptidase activity
NC3_RS06710	COG1609	Transcriptional regulator
NC3_RS06715	COG3711	transcriptional antiterminator
NC3_RS06720	COG1263	PTS System
NC3_RS06720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC3_RS06720	COG2190	(PTS) system
NC3_RS06725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC3_RS06730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NC3_RS06740	COG1533	DNA photolyase activity
NC3_RS06745	COG0840	transmembrane signaling receptor activity
NC3_RS06755	COG2084	Dehydrogenase
NC3_RS06760	COG2340	Cysteine-rich secretory protein family
NC3_RS06765	COG0768	penicillin binding
NC3_RS06770	COG4191	Histidine kinase
NC3_RS06775	COG0436	Aminotransferase
NC3_RS06780	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NC3_RS06790	COG1714	RDD family
NC3_RS06800	COG0784	Response regulator, receiver
NC3_RS06800	COG0835	chemotaxis
NC3_RS06810	COG1917	Cupin 2, conserved barrel domain protein
NC3_RS06810	COG2207	Transcriptional regulator
NC3_RS06830	COG2814	Major facilitator Superfamily
NC3_RS06835	COG1376	ErfK ybiS ycfS ynhG family protein
NC3_RS06840	COG1408	metallophosphoesterase
NC3_RS06845	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS06850	COG2200	EAL domain
NC3_RS06855	COG3546	catalase activity
NC3_RS06860	COG4703	Protein of unknown function (DUF1797)
NC3_RS06865	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NC3_RS06875	COG0517	IMP dehydrogenase activity
NC3_RS06880	COG0583	DNA-binding transcription factor activity
NC3_RS06890	COG0716	FMN binding
NC3_RS06900	COG0716	FMN binding
NC3_RS06905	COG2171	N-acyltransferase activity
NC3_RS06910	COG1473	amidohydrolase
NC3_RS06920	COG0668	transmembrane transport
NC3_RS06925	COG0450	alkyl hydroperoxide reductase
NC3_RS06930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NC3_RS06945	COG0746	molybdenum cofactor guanylyltransferase activity
NC3_RS06950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NC3_RS06955	COG0303	'Molybdopterin
NC3_RS06960	COG1763	Mo-molybdopterin cofactor biosynthetic process
NC3_RS06965	COG0314	molybdopterin synthase activity
NC3_RS06970	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NC3_RS06985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NC3_RS06990	COG1136	(ABC) transporter
NC3_RS06995	COG0577	efflux transmembrane transporter activity
NC3_RS07000	COG1349	DNA-binding transcription factor activity
NC3_RS07005	COG1105	Belongs to the carbohydrate kinase PfkB family
NC3_RS07010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NC3_RS07010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NC3_RS07010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC3_RS07015	COG0681	Belongs to the peptidase S26 family
NC3_RS07025	COG0488	(ABC) transporter
NC3_RS07030	COG2309	aminopeptidase activity
NC3_RS07040	COG1077	Cell shape determining protein MreB Mrl
NC3_RS07045	COG2002	toxin-antitoxin pair type II binding
NC3_RS07050	COG3852	Histidine kinase
NC3_RS07055	COG2105	PFAM AIG2 family protein
NC3_RS07055	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
NC3_RS07060	COG0569	domain protein
NC3_RS07065	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NC3_RS07070	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NC3_RS07075	COG5503	Protein of unknown function (DUF1447)
NC3_RS07080	COG0561	phosphatase activity
NC3_RS07085	COG0242	peptide deformylase activity
NC3_RS07100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NC3_RS07105	COG0022	dehydrogenase e1 component
NC3_RS07110	COG0508	dehydrogenase complex catalyzes the overall conversion of
NC3_RS07115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NC3_RS07120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NC3_RS07130	COG1982	Orn Lys Arg decarboxylase major
NC3_RS07135	COG4476	Belongs to the UPF0223 family
NC3_RS07140	COG4493	Belongs to the UPF0637 family
NC3_RS07150	COG0483	inositol monophosphate 1-phosphatase activity
NC3_RS07165	COG1595	DNA-templated transcription, initiation
NC3_RS07185	COG1217	gtp-binding protein TYPA
NC3_RS07195	COG4896	Protein conserved in bacteria
NC3_RS07205	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NC3_RS07210	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NC3_RS07215	COG2066	Belongs to the glutaminase family
NC3_RS07220	COG4838	Belongs to the UPF0358 family
NC3_RS07225	COG0772	Belongs to the SEDS family
NC3_RS07230	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NC3_RS07235	COG0415	Belongs to the DNA photolyase family
NC3_RS07240	COG1612	heme a metabolic process
NC3_RS07245	COG0109	protoheme IX farnesyltransferase activity
NC3_RS07250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NC3_RS07250	COG2010	Cytochrome c
NC3_RS07255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NC3_RS07260	COG1845	cytochrome c oxidase, subunit III
NC3_RS07265	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NC3_RS07270	COG3336	cytochrome c oxidase
NC3_RS07280	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
NC3_RS07285	COG2340	Cysteine-rich secretory protein family
NC3_RS07305	COG3679	Belongs to the UPF0342 family
NC3_RS07310	COG4471	UPF0298 protein
NC3_RS07315	COG0742	ribosomal rna small subunit methyltransferase
NC3_RS07320	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NC3_RS07325	COG3314	Sporulation integral membrane protein YlbJ
NC3_RS07330	COG1752	Esterase of the alpha-beta hydrolase superfamily
NC3_RS07335	COG3480	Lon protease (S16) C-terminal proteolytic domain
NC3_RS07345	COG1399	metal-binding, possibly nucleic acid-binding protein
NC3_RS07350	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NC3_RS07360	COG0454	-acetyltransferase
NC3_RS07365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NC3_RS07370	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
NC3_RS07375	COG2001	Belongs to the MraZ family
NC3_RS07380	COG0275	rRNA processing
NC3_RS07385	COG4839	cell division protein FtsL
NC3_RS07390	COG0768	penicillin binding
NC3_RS07395	COG0768	penicillin binding
NC3_RS07400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NC3_RS07405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NC3_RS07410	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NC3_RS07415	COG0772	Belongs to the SEDS family
NC3_RS07420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NC3_RS07425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NC3_RS07430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NC3_RS07435	COG3879	Bacterial protein of unknown function (DUF881)
NC3_RS07440	COG3879	Bacterial protein of unknown function (DUF881)
NC3_RS07445	COG3856	small basic protein
NC3_RS07450	COG0849	cell division
NC3_RS07455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NC3_RS07460	COG1404	Belongs to the peptidase S8 family
NC3_RS07460	COG4412	M6 family metalloprotease domain protein
NC3_RS07470	COG1191	sigma factor activity
NC3_RS07475	COG1191	sigma factor activity
NC3_RS07480	COG2390	Transcriptional regulator
NC3_RS07495	COG3730	PTS system glucitol sorbitol-specific
NC3_RS07500	COG3732	PTS system glucitol sorbitol-specific
NC3_RS07510	COG1119	ATPase activity
NC3_RS07515	COG1873	PFAM PRC-barrel domain
NC3_RS07520	COG1496	oxidoreductase activity
NC3_RS07525	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NC3_RS07530	COG1799	cell septum assembly
NC3_RS07535	COG0762	integral membrane protein
NC3_RS07540	COG2302	S4 RNA-binding domain
NC3_RS07545	COG3599	regulation of cell shape
NC3_RS07550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NC3_RS07555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NC3_RS07560	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NC3_RS07565	COG0564	pseudouridine synthase activity
NC3_RS07570	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NC3_RS07575	COG2233	PERMEase
NC3_RS07580	COG0540	Belongs to the ATCase OTCase family
NC3_RS07585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NC3_RS07590	COG0505	Belongs to the CarA family
NC3_RS07595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NC3_RS07600	COG0543	2 iron, 2 sulfur cluster binding
NC3_RS07605	COG0167	dihydroorotate dehydrogenase activity
NC3_RS07610	COG0284	orotidine-5'-phosphate decarboxylase activity
NC3_RS07615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NC3_RS07625	COG0175	sulfate reduction
NC3_RS07630	COG0306	phosphate transporter
NC3_RS07635	COG2046	Belongs to the sulfate adenylyltransferase family
NC3_RS07640	COG0529	Catalyzes the synthesis of activated sulfate
NC3_RS07645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NC3_RS07650	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
NC3_RS07655	COG1648	precorrin-2 dehydrogenase activity
NC3_RS07665	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NC3_RS07670	COG1561	YicC-like family, N-terminal region
NC3_RS07675	COG2052	Domain of unknown function (DUF370)
NC3_RS07680	COG0194	GDP metabolic process
NC3_RS07685	COG1758	RNA polymerase activity
NC3_RS07690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NC3_RS07695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NC3_RS07700	COG0242	peptide deformylase activity
NC3_RS07705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NC3_RS07710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NC3_RS07710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NC3_RS07715	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NC3_RS07720	COG0631	protein serine/threonine phosphatase activity
NC3_RS07725	COG2815	serine threonine protein kinase
NC3_RS07725	COG0515	serine threonine protein kinase
NC3_RS07730	COG1162	GTPase activity
NC3_RS07735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NC3_RS07740	COG1564	THIamine pyrophosphokinase
NC3_RS07750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NC3_RS07755	COG1302	Protein conserved in bacteria
NC3_RS07760	COG1461	Dihydroxyacetone kinase
NC3_RS07765	COG1760	l-serine dehydratase
NC3_RS07770	COG1760	l-serine dehydratase
NC3_RS07775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NC3_RS07780	COG1349	DNA-binding transcription factor activity
NC3_RS07785	COG0416	fatty acid biosynthetic process
NC3_RS07790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NC3_RS07795	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS07800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NC3_RS07810	COG1196	nuclear chromosome segregation
NC3_RS07815	COG0552	protein localization to endoplasmic reticulum
NC3_RS07820	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
NC3_RS07825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NC3_RS07830	COG0228	four-way junction DNA binding
NC3_RS07835	COG1837	Belongs to the UPF0109 family
NC3_RS07845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NC3_RS07850	COG0336	Belongs to the RNA methyltransferase TrmD family
NC3_RS07855	COG0335	large ribosomal subunit rRNA binding
NC3_RS07860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NC3_RS07865	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NC3_RS07875	COG2257	FlhB HrpN YscU SpaS Family
NC3_RS07880	COG0045	succinate-CoA ligase (ADP-forming) activity
NC3_RS07885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NC3_RS07890	COG0758	DNA mediated transformation
NC3_RS07895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NC3_RS07900	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NC3_RS07905	COG4974	Belongs to the 'phage' integrase family
NC3_RS07910	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NC3_RS07915	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NC3_RS07920	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NC3_RS07925	COG1815	bacterial-type flagellum-dependent cell motility
NC3_RS07930	COG1558	bacterial-type flagellum-dependent cell motility
NC3_RS07935	COG1677	Flagellar hook-basal body complex protein FliE
NC3_RS07940	COG1766	The M ring may be actively involved in energy transduction
NC3_RS07945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NC3_RS07950	COG1317	bacterial-type flagellum organization
NC3_RS07955	COG1157	protein secretion by the type III secretion system
NC3_RS07960	COG2882	bacterial-type flagellum organization
NC3_RS07965	COG3334	PFAM MgtE intracellular
NC3_RS07970	COG3144	bacterial-type flagellum assembly
NC3_RS07975	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NC3_RS07980	COG4786	Flagellar basal body rod
NC3_RS07985	COG1582	Flagellar protein (FlbD)
NC3_RS07990	COG1580	Controls the rotational direction of flagella during chemotaxis
NC3_RS07995	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NC3_RS08000	COG1776	CheC inhibitor of MCP methylation
NC3_RS08000	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NC3_RS08005	COG2201	protein-glutamate methylesterase activity
NC3_RS08010	COG3190	flagellar
NC3_RS08015	COG1338	Plays a role in the flagellum-specific transport system
NC3_RS08020	COG1987	bacterial-type flagellum assembly
NC3_RS08025	COG1684	flagellar biosynthetic protein fliR
NC3_RS08030	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NC3_RS08035	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NC3_RS08040	COG1419	protein localization to endoplasmic reticulum
NC3_RS08045	COG0455	bacterial-type flagellum organization
NC3_RS08050	COG2201	protein-glutamate methylesterase activity
NC3_RS08055	COG2198	Histidine kinase
NC3_RS08055	COG0643	Histidine kinase
NC3_RS08060	COG0835	chemotaxis
NC3_RS08065	COG1776	CheC inhibitor of MCP methylation
NC3_RS08075	COG1191	sigma factor activity
NC3_RS08090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NC3_RS08095	COG0528	UMP kinase activity
NC3_RS08100	COG0233	cytoplasmic translational termination
NC3_RS08105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NC3_RS08110	COG4589	Belongs to the CDS family
NC3_RS08115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NC3_RS08120	COG0750	zinc metalloprotease
NC3_RS08125	COG0442	prolyl-tRNA aminoacylation
NC3_RS08130	COG2176	DNA-directed DNA polymerase activity
NC3_RS08145	COG3693	PFAM glycoside hydrolase, family 10
NC3_RS08155	COG0779	Required for maturation of 30S ribosomal subunits
NC3_RS08160	COG0195	Participates in both transcription termination and antitermination
NC3_RS08165	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NC3_RS08170	COG1358	cellular component organization or biogenesis
NC3_RS08175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NC3_RS08180	COG1550	Protein conserved in bacteria
NC3_RS08185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NC3_RS08190	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NC3_RS08195	COG0196	riboflavin kinase activity
NC3_RS08200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NC3_RS08205	COG1185	polyribonucleotide nucleotidyltransferase activity
NC3_RS08210	COG0726	polysaccharide deacetylase
NC3_RS08215	COG0612	Peptidase, M16
NC3_RS08225	COG1873	PFAM PRC-barrel domain
NC3_RS08230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NC3_RS08235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NC3_RS08240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NC3_RS08245	COG0527	aspartate kinase activity
NC3_RS08255	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NC3_RS08260	COG0740	serine-type endopeptidase activity
NC3_RS08270	COG1674	ftsk spoiiie
NC3_RS08270	COG4980	gas vesicle protein
NC3_RS08275	COG2188	Transcriptional regulator
NC3_RS08280	COG2814	Major facilitator Superfamily
NC3_RS08285	COG1033	growth of symbiont in host cell
NC3_RS08285	COG2409	Drug exporters of the RND superfamily
NC3_RS08290	COG0612	Peptidase, M16
NC3_RS08295	COG0612	Peptidase, M16
NC3_RS08305	COG2409	Drug exporters of the RND superfamily
NC3_RS08305	COG1033	growth of symbiont in host cell
NC3_RS08310	COG0300	oxidoreductase activity
NC3_RS08325	COG1426	Protein conserved in bacteria
NC3_RS08330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NC3_RS08335	COG1058	Belongs to the CinA family
NC3_RS08335	COG1546	Belongs to the CinA family
NC3_RS08340	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NC3_RS08345	COG1418	mRNA catabolic process
NC3_RS08350	COG1692	metallophosphoesterase
NC3_RS08355	COG2359	stage V sporulation protein S
NC3_RS08360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NC3_RS08365	COG1063	alcohol dehydrogenase
NC3_RS08370	COG0156	8-amino-7-oxononanoate synthase activity
NC3_RS08375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NC3_RS08380	COG4550	Control of competence regulator ComK, YlbF/YmcA
NC3_RS08390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NC3_RS08395	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NC3_RS08415	COG1329	Transcriptional regulator
NC3_RS08420	COG4195	phage-related replication protein
NC3_RS08425	COG0457	Tetratricopeptide repeat
NC3_RS08430	COG1404	Belongs to the peptidase S8 family
NC3_RS08435	COG4195	phage-related replication protein
NC3_RS08440	COG1764	response to oxidative stress
NC3_RS08470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NC3_RS08475	COG1923	regulation of RNA biosynthetic process
NC3_RS08490	COG1780	Probably involved in ribonucleotide reductase function
NC3_RS08495	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NC3_RS08500	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NC3_RS08505	COG4112	unkown
NC3_RS08515	COG0464	growth
NC3_RS08520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NC3_RS08525	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NC3_RS08530	COG0789	Transcriptional regulator
NC3_RS08535	COG0174	glutamine synthetase
NC3_RS08570	COG0494	nUDIX hydrolase
NC3_RS08575	COG0457	Tetratricopeptide repeat
NC3_RS08590	COG5444	nuclease activity
NC3_RS08615	COG5646	InterPro IPR014922
NC3_RS08640	COG0457	Tetratricopeptide repeat
NC3_RS08650	COG3619	membrane
NC3_RS08655	COG3285	dna ligase
NC3_RS08655	COG1793	dna ligase
NC3_RS08660	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NC3_RS08665	COG4876	unkown
NC3_RS08675	COG1959	2 iron, 2 sulfur cluster binding
NC3_RS08680	COG0702	epimerase
NC3_RS08690	COG0247	lactate metabolic process
NC3_RS08695	COG1139	Iron-sulfur cluster binding protein
NC3_RS08700	COG1556	Lactate utilization protein
NC3_RS08720	COG2323	membrane
NC3_RS08725	COG1309	transcriptional regulator
NC3_RS08730	COG2124	cytochrome p450
NC3_RS08730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NC3_RS08735	COG3591	Belongs to the peptidase S1B family
NC3_RS08740	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NC3_RS08745	COG3209	COG3209 Rhs family protein
NC3_RS08750	COG1366	Belongs to the anti-sigma-factor antagonist family
NC3_RS08765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NC3_RS08770	COG1388	LysM domain
NC3_RS08775	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NC3_RS08780	COG4224	UPF0291 protein
NC3_RS08785	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NC3_RS08795	COG3763	UPF0154 protein
NC3_RS08805	COG0785	Cytochrome C biogenesis protein
NC3_RS08810	COG4846	Membrane protein involved in cytochrome C biogenesis
NC3_RS08820	COG0071	Belongs to the small heat shock protein (HSP20) family
NC3_RS08835	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NC3_RS08840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NC3_RS08860	COG0824	Thioesterase
NC3_RS08870	COG4841	protein insertion into membrane
NC3_RS08875	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NC3_RS08880	COG1832	CoA-binding protein
NC3_RS08885	COG0187	DNA topoisomerase II activity
NC3_RS08890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NC3_RS08900	COG0738	Major facilitator superfamily
NC3_RS08905	COG0473	3-isopropylmalate dehydrogenase activity
NC3_RS08910	COG0110	maltose O-acetyltransferase activity
NC3_RS08915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NC3_RS08920	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NC3_RS08925	COG0640	Transcriptional regulator
NC3_RS08940	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NC3_RS08945	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NC3_RS08955	COG1309	transcriptional regulator
NC3_RS08960	COG2249	NAD(P)H dehydrogenase (quinone) activity
NC3_RS08965	COG1733	regulation of RNA biosynthetic process
NC3_RS08970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NC3_RS08975	COG0251	oxidation-reduction process
NC3_RS09015	COG0657	acetylesterase activity
NC3_RS09025	COG2723	6-phospho-beta-galactosidase activity
NC3_RS09030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC3_RS09030	COG2190	(PTS) system
NC3_RS09030	COG1263	PTS System
NC3_RS09045	COG2205	protein histidine kinase activity
NC3_RS09050	COG0745	RESPONSE REGULATOR receiver
NC3_RS09060	COG3507	Belongs to the glycosyl hydrolase 43 family
NC3_RS09065	COG1012	belongs to the aldehyde dehydrogenase family
NC3_RS09070	COG1486	melibiose metabolic process
NC3_RS09075	COG0395	ABC-type sugar transport system, permease component
NC3_RS09080	COG1175	transmembrane transport
NC3_RS09085	COG1653	transport
NC3_RS09090	COG1609	Transcriptional regulator
NC3_RS09095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NC3_RS09110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC3_RS09120	COG0456	acetyltransferase
NC3_RS09125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NC3_RS09140	COG5444	nuclease activity
NC3_RS09155	COG1846	Transcriptional regulator
NC3_RS09160	COG2814	Major facilitator Superfamily
NC3_RS09170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NC3_RS09170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NC3_RS09170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC3_RS09175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC3_RS09175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NC3_RS09175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NC3_RS09180	COG1105	Belongs to the carbohydrate kinase PfkB family
NC3_RS09190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NC3_RS09210	COG1012	belongs to the aldehyde dehydrogenase family
NC3_RS09215	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NC3_RS09220	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NC3_RS09225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NC3_RS09230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NC3_RS09235	COG1024	Enoyl-CoA hydratase
NC3_RS09240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NC3_RS09245	COG0511	ligase activity, forming carbon-carbon bonds
NC3_RS09250	COG0439	Biotin carboxylase
NC3_RS09255	COG0318	PFAM AMP-dependent synthetase and ligase
NC3_RS09260	COG1960	acyl-CoA dehydrogenase activity
NC3_RS09265	COG1649	PFAM Uncharacterised BCR, COG1649
NC3_RS09270	COG2365	Tyrosine phosphatase family
NC3_RS09275	COG1349	DNA-binding transcription factor activity
NC3_RS09280	COG1942	4-Oxalocrotonate Tautomerase
NC3_RS09290	COG3835	regulator
NC3_RS09295	COG0277	FAD linked oxidase domain protein
NC3_RS09300	COG0247	lactate metabolic process
NC3_RS09320	COG0166	Belongs to the GPI family
NC3_RS09325	COG2246	polysaccharide biosynthetic process
NC3_RS09330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NC3_RS09335	COG0586	Pfam SNARE associated Golgi protein
NC3_RS09340	COG1587	Uroporphyrinogen-III synthase
NC3_RS09350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NC3_RS09370	COG0534	Mate efflux family protein
NC3_RS09375	COG2027	D-alanyl-D-alanine carboxypeptidase
NC3_RS09380	COG4677	pectinesterase activity
NC3_RS09385	COG2323	membrane
NC3_RS09390	COG2146	nitrite reductase [NAD(P)H] activity
NC3_RS09395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NC3_RS09400	COG0243	molybdopterin cofactor binding
NC3_RS09405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NC3_RS09410	COG2223	nitrite transmembrane transporter activity
NC3_RS09415	COG0493	'glutamate synthase
NC3_RS09420	COG0067	glutamate synthase
NC3_RS09420	COG0069	glutamate synthase activity
NC3_RS09420	COG0070	glutamate synthase
NC3_RS09425	COG0583	DNA-binding transcription factor activity
NC3_RS09435	COG1132	(ABC) transporter
NC3_RS09440	COG4978	Transcriptional regulator
NC3_RS09440	COG0789	Transcriptional regulator
NC3_RS09445	COG0454	-acetyltransferase
NC3_RS09450	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NC3_RS09455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NC3_RS09460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NC3_RS09470	COG0243	molybdopterin cofactor binding
NC3_RS09480	COG1070	Carbohydrate kinase
NC3_RS09485	COG2115	Belongs to the xylose isomerase family
NC3_RS09490	COG1940	carbohydrate kinase activity
NC3_RS09500	COG2211	Major facilitator Superfamily
NC3_RS09505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NC3_RS09510	COG1994	Peptidase M50
NC3_RS09530	COG1309	transcriptional regulator
NC3_RS09535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NC3_RS09540	COG3708	Transcriptional regulator
NC3_RS09545	COG2378	regulation of single-species biofilm formation
NC3_RS09555	COG0640	Transcriptional regulator
NC3_RS09560	COG0531	amino acid
NC3_RS09565	COG0741	lytic transglycosylase activity
NC3_RS09570	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NC3_RS09575	COG2079	MmgE PrpD family protein
NC3_RS09580	COG0372	Belongs to the citrate synthase family
NC3_RS09585	COG2322	membrane
NC3_RS09595	COG3584	3D domain protein
NC3_RS09595	COG1388	LysM domain
NC3_RS09600	COG0514	ATP-dependent DNA helicase (RecQ)
NC3_RS09610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NC3_RS09635	COG1012	belongs to the aldehyde dehydrogenase family
NC3_RS09640	COG1657	PFAM Prenyltransferase squalene oxidase
NC3_RS09645	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NC3_RS09650	COG0385	Bile acid
NC3_RS09655	COG0508	dehydrogenase complex catalyzes the overall conversion of
NC3_RS09660	COG0567	Dehydrogenase, E1 component
NC3_RS09665	COG4548	von Willebrand factor, type A
NC3_RS09670	COG0714	Associated with various cellular activities
NC3_RS09675	COG2032	superoxide dismutase activity
NC3_RS09680	COG0791	NLP P60 protein
NC3_RS09680	COG1388	LysM domain
NC3_RS09685	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NC3_RS09690	COG0534	Mate efflux family protein
NC3_RS09695	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NC3_RS09700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NC3_RS09710	COG2962	Rard protein
NC3_RS09725	COG1733	regulation of RNA biosynthetic process
NC3_RS09730	COG0778	Nitroreductase
NC3_RS09740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NC3_RS09745	COG0793	Belongs to the peptidase S41A family
NC3_RS09745	COG3409	Peptidoglycan-binding domain 1 protein
NC3_RS09750	COG2226	methyltransferase
NC3_RS09760	COG1876	peptidase activity
NC3_RS09765	COG0813	purine-nucleoside phosphorylase activity
NC3_RS09775	COG0671	phosphoesterase, PA-phosphatase related
NC3_RS09790	COG4479	Belongs to the UPF0346 family
NC3_RS09800	COG1509	lysine 2,3-aminomutase activity
NC3_RS09805	COG3829	transcription factor binding
NC3_RS09810	COG0463	Glycosyl transferase, family 2
NC3_RS09825	COG4641	Protein conserved in bacteria
NC3_RS09835	COG1086	Polysaccharide biosynthesis protein
NC3_RS09840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NC3_RS09845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NC3_RS09850	COG1846	Transcriptional regulator
NC3_RS09870	COG4698	Protein conserved in bacteria
NC3_RS09875	COG2755	lipolytic protein G-D-S-L family
NC3_RS09880	COG1999	signal sequence binding
NC3_RS09895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NC3_RS09900	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NC3_RS09905	COG1272	protein, Hemolysin III
NC3_RS09910	COG0204	Acyl-transferase
NC3_RS09915	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NC3_RS09920	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NC3_RS09925	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NC3_RS09935	COG2136	Putative SAM-dependent methyltransferase
NC3_RS09935	COG2521	methyltransferase
NC3_RS09945	COG0129	dihydroxy-acid dehydratase activity
NC3_RS09950	COG1413	lyase activity
NC3_RS09955	COG1418	mRNA catabolic process
NC3_RS09960	COG0386	Belongs to the glutathione peroxidase family
NC3_RS09965	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NC3_RS09970	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NC3_RS09975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NC3_RS09985	COG1278	Cold shock
NC3_RS10000	COG0328	RNA-DNA hybrid ribonuclease activity
NC3_RS10005	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NC3_RS10010	COG0328	RNA-DNA hybrid ribonuclease activity
NC3_RS10020	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NC3_RS10030	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NC3_RS10035	COG1755	Isoprenylcysteine carboxyl methyltransferase
NC3_RS10040	COG3424	synthase
NC3_RS10045	COG0456	acetyltransferase
NC3_RS10045	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NC3_RS10050	COG0726	polysaccharide deacetylase
NC3_RS10055	COG2233	PERMEase
NC3_RS10060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NC3_RS10065	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NC3_RS10070	COG1199	ATP-dependent helicase activity
NC3_RS10080	COG0116	Belongs to the methyltransferase superfamily
NC3_RS10090	COG3599	regulation of cell shape
NC3_RS10095	COG4474	Belongs to the UPF0398 family
NC3_RS10105	COG3359	exonuclease
NC3_RS10110	COG1205	dead DEAH box helicase
NC3_RS10110	COG1111	helicase
NC3_RS10115	COG1902	pentaerythritol trinitrate reductase activity
NC3_RS10120	COG2190	(PTS) system
NC3_RS10125	COG0071	Belongs to the small heat shock protein (HSP20) family
NC3_RS10155	COG3331	DNA recombination
NC3_RS10160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NC3_RS10160	COG4499	WXG100 protein secretion system (Wss), protein YukC
NC3_RS10170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NC3_RS10175	COG3935	DnaD domain protein
NC3_RS10180	COG0017	Asparaginyl-tRNA synthetase
NC3_RS10185	COG5353	protein conserved in bacteria
NC3_RS10195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NC3_RS10195	COG1199	ATP-dependent helicase activity
NC3_RS10200	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NC3_RS10205	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NC3_RS10210	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NC3_RS10220	COG0617	tRNA 3'-terminal CCA addition
NC3_RS10225	COG0438	transferase activity, transferring glycosyl groups
NC3_RS10230	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NC3_RS10235	COG1803	Methylglyoxal synthase
NC3_RS10240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NC3_RS10245	COG1694	Mazg nucleotide pyrophosphohydrolase
NC3_RS10250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NC3_RS10260	COG4347	Protein of unknown function (DUF1405)
NC3_RS10265	COG2010	Cytochrome c
NC3_RS10265	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NC3_RS10270	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NC3_RS10275	COG0723	plastoquinol--plastocyanin reductase activity
NC3_RS10285	COG5582	Belongs to the UPF0302 family
NC3_RS10290	COG0457	Tetratricopeptide repeat
NC3_RS10295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NC3_RS10300	COG0287	Prephenate dehydrogenase
NC3_RS10305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NC3_RS10310	COG0159	tryptophan synthase activity
NC3_RS10315	COG0133	tryptophan synthase activity
NC3_RS10320	COG0135	phosphoribosylanthranilate isomerase activity
NC3_RS10325	COG0134	indole-3-glycerol-phosphate synthase activity
NC3_RS10330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NC3_RS10340	COG4401	Chorismate mutase type I
NC3_RS10345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NC3_RS10350	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NC3_RS10355	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NC3_RS10360	COG0105	UTP biosynthetic process
NC3_RS10365	COG0142	geranyltranstransferase activity
NC3_RS10370	COG2226	methyltransferase
NC3_RS10375	COG0142	geranyltranstransferase activity
NC3_RS10385	COG0302	gtp cyclohydrolase
NC3_RS10390	COG0776	regulation of translation
NC3_RS10395	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NC3_RS10410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NC3_RS10415	COG1160	GTP binding
NC3_RS10440	COG1304	FMN binding
NC3_RS10445	COG0539	negative regulation of cytoplasmic translation
NC3_RS10450	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NC3_RS10460	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
NC3_RS10465	COG2959	enzyme of heme biosynthesis
NC3_RS10470	COG3409	Peptidoglycan-binding domain 1 protein
NC3_RS10470	COG3773	Cell wall hydrolase
NC3_RS10475	COG2339	peptidase activity
NC3_RS10480	COG0492	ferredoxin-NADP+ reductase activity
NC3_RS10485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NC3_RS10490	COG4862	establishment of competence for transformation
NC3_RS10495	COG1408	metallophosphoesterase
NC3_RS10505	COG1388	LysM domain
NC3_RS10510	COG1266	CAAX protease self-immunity
NC3_RS10515	COG0514	ATP-dependent DNA helicase (RecQ)
NC3_RS10520	COG4955	Helix-turn-helix domain
NC3_RS10525	COG1141	Ferredoxin
NC3_RS10530	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NC3_RS10535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NC3_RS10550	COG1595	DNA-templated transcription, initiation
NC3_RS10555	COG5002	protein histidine kinase activity
NC3_RS10560	COG0745	RESPONSE REGULATOR receiver
NC3_RS10565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NC3_RS10570	COG1333	cytochrome c biogenesis protein
NC3_RS10575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NC3_RS10580	COG1187	pseudouridine synthase activity
NC3_RS10585	COG0700	Nucleoside recognition
NC3_RS10590	COG2715	membrane protein required for spore maturation
NC3_RS10595	COG1686	Belongs to the peptidase S11 family
NC3_RS10605	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NC3_RS10610	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NC3_RS10620	COG1547	Domain of unknown function (DUF309)
NC3_RS10625	COG0456	acetyltransferase
NC3_RS10630	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NC3_RS10640	COG0307	riboflavin synthase, alpha
NC3_RS10660	COG2814	Major facilitator Superfamily
NC3_RS10665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NC3_RS10670	COG4086	secreted protein
NC3_RS10675	COG0019	diaminopimelate decarboxylase activity
NC3_RS10680	COG0697	spore germination
NC3_RS10695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NC3_RS10715	COG1191	sigma factor activity
NC3_RS10720	COG2172	sigma factor antagonist activity
NC3_RS10730	COG1686	Belongs to the peptidase S11 family
NC3_RS10735	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NC3_RS10740	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NC3_RS10745	COG4974	Belongs to the 'phage' integrase family
NC3_RS10755	COG0735	belongs to the Fur family
NC3_RS10760	COG1300	Membrane
NC3_RS10765	COG1404	Belongs to the peptidase S8 family
NC3_RS10775	COG2153	protein acetylation
NC3_RS10780	COG1379	DNA repair
NC3_RS10785	COG0494	nUDIX hydrolase
NC3_RS10790	COG0667	Aldo Keto reductase
NC3_RS10800	COG1073	alpha beta
NC3_RS10805	COG0457	Tetratricopeptide repeat
NC3_RS10815	COG4918	Iron-sulphur cluster biosynthesis
NC3_RS10820	COG4305	rare lipoprotein A
NC3_RS10825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NC3_RS10825	COG0456	acetyltransferase
NC3_RS10830	COG0456	acetyltransferase
NC3_RS10840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NC3_RS10850	COG2211	Major facilitator Superfamily
NC3_RS10855	COG1072	(Pantothenic acid kinase))
NC3_RS10860	COG0446	pyridine nucleotide-disulphide oxidoreductase
NC3_RS10870	COG0300	oxidoreductase activity
NC3_RS10875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NC3_RS10880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NC3_RS10890	COG4187	Peptidase family M20/M25/M40
NC3_RS10895	COG1902	pentaerythritol trinitrate reductase activity
NC3_RS10900	COG0596	Alpha beta hydrolase
NC3_RS10905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NC3_RS10915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NC3_RS10920	COG2188	Transcriptional regulator
NC3_RS10925	COG2723	6-phospho-beta-galactosidase activity
NC3_RS10930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NC3_RS10935	COG1447	Phosphotransferase system cellobiose-specific component IIA
NC3_RS10940	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NC3_RS10950	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS10960	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NC3_RS10965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NC3_RS10975	COG0706	membrane insertase activity
NC3_RS10980	COG0835	chemotaxis
NC3_RS10985	COG2195	Cleaves the N-terminal amino acid of tripeptides
NC3_RS10990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NC3_RS10995	COG0346	lactoylglutathione lyase activity
NC3_RS11005	COG1376	ErfK ybiS ycfS ynhG family protein
NC3_RS11010	COG4129	membrane
NC3_RS11015	COG1126	abc transporter atp-binding protein
NC3_RS11020	COG0765	amino acid transport
NC3_RS11025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC3_RS11035	COG1597	lipid kinase activity
NC3_RS11045	COG0508	dehydrogenase complex catalyzes the overall conversion of
NC3_RS11050	COG0022	dehydrogenase e1 component
NC3_RS11055	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NC3_RS11060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NC3_RS11065	COG3426	butyrate kinase activity
NC3_RS11070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NC3_RS11075	COG0280	phosphate acetyltransferase
NC3_RS11080	COG3829	transcription factor binding
NC3_RS11080	COG3290	protein histidine kinase activity
NC3_RS11090	COG0584	glycerophosphoryl diester phosphodiesterase
NC3_RS11095	COG0457	Tetratricopeptide repeat
NC3_RS11100	COG0745	RESPONSE REGULATOR receiver
NC3_RS11105	COG0750	zinc metalloprotease
NC3_RS11110	COG0497	DNA recombination
NC3_RS11115	COG1438	arginine binding
NC3_RS11120	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NC3_RS11125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NC3_RS11130	COG0142	geranyltranstransferase activity
NC3_RS11135	COG1722	exodeoxyribonuclease VII activity
NC3_RS11140	COG1570	exodeoxyribonuclease VII activity
NC3_RS11145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NC3_RS11150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NC3_RS11155	COG1302	Protein conserved in bacteria
NC3_RS11160	COG0439	Biotin carboxylase
NC3_RS11165	COG0511	ligase activity, forming carbon-carbon bonds
NC3_RS11205	COG3854	ATPases associated with a variety of cellular activities
NC3_RS11215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NC3_RS11220	COG0006	proline dipeptidase activity
NC3_RS11225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NC3_RS11235	COG3872	metal-dependent enzyme
NC3_RS11245	COG1752	Esterase of the alpha-beta hydrolase superfamily
NC3_RS11250	COG1321	iron dependent repressor
NC3_RS11255	COG0095	Lipoate-protein ligase
NC3_RS11260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NC3_RS11265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NC3_RS11270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NC3_RS11275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NC3_RS11280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NC3_RS11305	COG0681	Belongs to the peptidase S26 family
NC3_RS11340	COG4970	Tfp pilus assembly protein FimT
NC3_RS11345	COG4537	Required for transformation and DNA binding
NC3_RS11350	COG1459	type II secretion system
NC3_RS11355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NC3_RS11360	COG1366	Belongs to the anti-sigma-factor antagonist family
NC3_RS11370	COG1393	Belongs to the ArsC family
NC3_RS11380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NC3_RS11390	COG0011	TIGRFAM Protein of
NC3_RS11395	COG2814	Major facilitator Superfamily
NC3_RS11400	COG2866	Carboxypeptidase
NC3_RS11405	COG1368	sulfuric ester hydrolase activity
NC3_RS11410	COG1940	carbohydrate kinase activity
NC3_RS11415	COG4483	Protein conserved in bacteria
NC3_RS11420	COG0457	Tetratricopeptide repeat
NC3_RS11420	COG0705	Rhomboid family
NC3_RS11435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NC3_RS11440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NC3_RS11450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NC3_RS11455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NC3_RS11460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NC3_RS11465	COG0581	inorganic phosphate transmembrane transporter activity
NC3_RS11470	COG0573	inorganic phosphate transmembrane transporter activity
NC3_RS11475	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NC3_RS11480	COG0768	penicillin binding
NC3_RS11485	COG0477	Major facilitator Superfamily
NC3_RS11490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NC3_RS11495	COG2839	Protein conserved in bacteria
NC3_RS11500	COG5521	maltodextrose utilization protein MalA
NC3_RS11505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NC3_RS11510	COG1388	LysM domain
NC3_RS11515	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NC3_RS11520	COG4709	membrane
NC3_RS11525	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
NC3_RS11530	COG1940	carbohydrate kinase activity
NC3_RS11535	COG0735	belongs to the Fur family
NC3_RS11540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NC3_RS11545	COG1121	(ABC) transporter
NC3_RS11550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NC3_RS11565	COG0513	Belongs to the DEAD box helicase family
NC3_RS11575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NC3_RS11580	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NC3_RS11585	COG2384	SAM-dependent methyltransferase
NC3_RS11590	COG2010	Cytochrome c
NC3_RS11595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NC3_RS11600	COG0358	DNA primase activity
NC3_RS11605	COG1671	Belongs to the UPF0178 family
NC3_RS11610	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NC3_RS11615	COG0517	IMP dehydrogenase activity
NC3_RS11620	COG0751	glycine-tRNA ligase activity
NC3_RS11625	COG0752	glycyl-tRNA synthetase alpha subunit
NC3_RS11630	COG1381	Involved in DNA repair and RecF pathway recombination
NC3_RS11640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NC3_RS11645	COG0295	cytidine deaminase activity
NC3_RS11650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NC3_RS11655	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NC3_RS11660	COG1480	7TM receptor with intracellular HD hydrolase
NC3_RS11665	COG1702	phosphate starvation-inducible protein PhoH
NC3_RS11670	COG0561	phosphatase activity
NC3_RS11685	COG4864	UPF0365 protein
NC3_RS11690	COG1030	water channel activity
NC3_RS11695	COG1610	YqeY-like protein
NC3_RS11705	COG1283	sodium-dependent phosphate transmembrane transporter activity
NC3_RS11710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NC3_RS11715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NC3_RS11720	COG2264	protein methyltransferase activity
NC3_RS11725	COG0484	heat shock protein binding
NC3_RS11730	COG0443	Heat shock 70 kDa protein
NC3_RS11735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NC3_RS11740	COG1420	regulation of RNA biosynthetic process
NC3_RS11745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NC3_RS11750	COG0481	GTPase activity
NC3_RS11760	COG0860	N-Acetylmuramoyl-L-alanine amidase
NC3_RS11765	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NC3_RS11770	COG0268	Binds directly to 16S ribosomal RNA
NC3_RS11775	COG1466	dna polymerase III delta subunit
NC3_RS11785	COG0658	competence protein
NC3_RS11785	COG2333	competence protein COMEC
NC3_RS11790	COG2131	deaminase
NC3_RS11795	COG1555	photosystem II stabilization
NC3_RS11795	COG1596	polysaccharide export
NC3_RS11800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NC3_RS11805	COG2226	methyltransferase
NC3_RS11810	COG0799	negative regulation of ribosome biogenesis
NC3_RS11815	COG1713	HD superfamily hydrolase involved in NAD metabolism
NC3_RS11820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NC3_RS11825	COG1534	Rna-binding protein
NC3_RS11830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NC3_RS11835	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NC3_RS11840	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NC3_RS11855	COG2755	lipolytic protein G-D-S-L family
NC3_RS11865	COG0457	Tetratricopeptide repeat
NC3_RS11885	COG2186	Transcriptional regulator
NC3_RS11900	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS11905	COG3958	Transketolase
NC3_RS11910	COG3959	Transketolase, thiamine diphosphate binding domain
NC3_RS11930	COG0726	polysaccharide deacetylase
NC3_RS11965	COG1131	(ABC) transporter
NC3_RS11990	COG2160	L-arabinose isomerase activity
NC3_RS12005	COG1609	Transcriptional regulator
NC3_RS12015	COG1846	Transcriptional regulator
NC3_RS12025	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NC3_RS12030	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
NC3_RS12035	COG1733	regulation of RNA biosynthetic process
NC3_RS12040	COG0657	acetylesterase activity
NC3_RS12065	COG3209	COG3209 Rhs family protein
NC3_RS12070	COG2602	Beta-lactamase
NC3_RS12075	COG1960	acyl-CoA dehydrogenase activity
NC3_RS12080	COG1126	abc transporter atp-binding protein
NC3_RS12085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC3_RS12090	COG0765	amino acid transport
NC3_RS12100	COG3546	catalase activity
NC3_RS12105	COG1063	alcohol dehydrogenase
NC3_RS12115	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS12125	COG1115	amino acid carrier protein
NC3_RS12130	COG0583	DNA-binding transcription factor activity
NC3_RS12135	COG0842	Transport permease protein
NC3_RS12140	COG0842	Transport permease protein
NC3_RS12140	COG1511	domain protein
NC3_RS12145	COG1131	(ABC) transporter
NC3_RS12150	COG1063	alcohol dehydrogenase
NC3_RS12155	COG2226	methyltransferase
NC3_RS12180	COG0626	cystathionine gamma-synthase activity
NC3_RS12185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NC3_RS12190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NC3_RS12195	COG2226	methyltransferase
NC3_RS12210	COG0768	penicillin binding
NC3_RS12215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NC3_RS12220	COG0572	uridine kinase
NC3_RS12225	COG0826	peptidase U32
NC3_RS12230	COG0826	peptidase U32
NC3_RS12235	COG4122	O-methyltransferase activity
NC3_RS12240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NC3_RS12245	COG0183	Belongs to the thiolase family
NC3_RS12250	COG0318	PFAM AMP-dependent synthetase and ligase
NC3_RS12255	COG1268	BioY protein
NC3_RS12265	COG3906	Belongs to the UPF0473 family
NC3_RS12270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NC3_RS12275	COG4472	Bacterial protein of unknown function (DUF965)
NC3_RS12280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NC3_RS12285	COG0628	permease
NC3_RS12290	COG1126	abc transporter atp-binding protein
NC3_RS12295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC3_RS12300	COG0765	amino acid transport
NC3_RS12305	COG0765	amino acid transport
NC3_RS12320	COG3881	PFAM PRC-barrel domain
NC3_RS12325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NC3_RS12330	COG0457	Tetratricopeptide repeat
NC3_RS12335	COG0482	sulfurtransferase activity
NC3_RS12340	COG1104	cysteine desulfurase activity
NC3_RS12345	COG1959	2 iron, 2 sulfur cluster binding
NC3_RS12350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NC3_RS12355	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NC3_RS12370	COG0124	histidyl-tRNA synthetase
NC3_RS12380	COG3103	Sh3 type 3 domain protein
NC3_RS12380	COG0860	N-Acetylmuramoyl-L-alanine amidase
NC3_RS12380	COG4991	sh3 domain protein
NC3_RS12385	COG1490	D-aminoacyl-tRNA deacylase activity
NC3_RS12390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NC3_RS12395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NC3_RS12400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NC3_RS12400	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NC3_RS12405	COG5416	Lipopolysaccharide assembly protein A domain
NC3_RS12410	COG0490	domain, Protein
NC3_RS12415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NC3_RS12415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NC3_RS12425	COG2244	polysaccharide biosynthetic process
NC3_RS12430	COG2323	membrane
NC3_RS12440	COG1862	Preprotein translocase
NC3_RS12445	COG0343	queuine tRNA-ribosyltransferase activity
NC3_RS12450	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NC3_RS12460	COG2255	four-way junction helicase activity
NC3_RS12465	COG0632	four-way junction helicase activity
NC3_RS12475	COG2112	serine threonine protein kinase
NC3_RS12490	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NC3_RS12505	COG1388	LysM domain
NC3_RS12510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NC3_RS12515	COG0157	Belongs to the NadC ModD family
NC3_RS12520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NC3_RS12525	COG1104	cysteine desulfurase activity
NC3_RS12530	COG1827	regulation of RNA biosynthetic process
NC3_RS12535	COG0077	Prephenate dehydratase
NC3_RS12540	COG4492	Belongs to the UPF0735 family
NC3_RS12545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NC3_RS12550	COG3290	protein histidine kinase activity
NC3_RS12555	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NC3_RS12560	COG2868	ribosomal protein
NC3_RS12565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NC3_RS12570	COG1994	Peptidase M50
NC3_RS12575	COG0739	heme binding
NC3_RS12580	COG2894	cell division
NC3_RS12585	COG0850	regulation of cytokinetic process
NC3_RS12590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NC3_RS12600	COG1077	Cell shape determining protein MreB Mrl
NC3_RS12605	COG2003	Belongs to the UPF0758 family
NC3_RS12610	COG0424	maF-like protein
NC3_RS12625	COG0285	dihydrofolate synthase activity
NC3_RS12630	COG0525	valine-tRNA ligase activity
NC3_RS12640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NC3_RS12645	COG1388	LysM domain
NC3_RS12650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NC3_RS12655	COG0113	porphobilinogen synthase activity
NC3_RS12660	COG1587	Uroporphyrinogen-III synthase
NC3_RS12665	COG0181	hydroxymethylbilane synthase activity
NC3_RS12670	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NC3_RS12675	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NC3_RS12685	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NC3_RS12690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NC3_RS12695	COG0470	DNA polymerase III
NC3_RS12695	COG1067	ATP-dependent peptidase activity
NC3_RS12700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NC3_RS12705	COG0544	peptidyl-prolyl cis-trans isomerase activity
NC3_RS12710	COG1477	protein flavinylation
NC3_RS12710	COG0457	Tetratricopeptide repeat
NC3_RS12715	COG0066	3-isopropylmalate dehydratase activity
NC3_RS12720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NC3_RS12725	COG0473	3-isopropylmalate dehydrogenase activity
NC3_RS12730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NC3_RS12735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NC3_RS12740	COG0440	acetolactate synthase activity
NC3_RS12745	COG0028	Belongs to the TPP enzyme family
NC3_RS12750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NC3_RS12755	COG2706	6-phosphogluconolactonase activity
NC3_RS12760	COG3339	Conserved Protein
NC3_RS12765	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NC3_RS12770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NC3_RS12775	COG1696	Membrane protein involved in D-alanine export
NC3_RS12780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NC3_RS12830	COG0582	viral genome integration into host DNA
NC3_RS12840	COG0622	Phosphoesterase
NC3_RS12845	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NC3_RS12850	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NC3_RS12855	COG5401	PFAM Sporulation and spore germination
NC3_RS12860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NC3_RS12865	COG1846	Transcriptional regulator
NC3_RS12870	COG2197	response regulator
NC3_RS12875	COG2851	Citrate transporter
NC3_RS12880	COG0583	DNA-binding transcription factor activity
NC3_RS12885	COG2828	Protein conserved in bacteria
NC3_RS12895	COG0824	Thioesterase
NC3_RS12900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NC3_RS12905	COG1053	succinate dehydrogenase
NC3_RS12910	COG2009	succinate dehydrogenase
NC3_RS12915	COG1719	4-vinyl reductase, 4VR
NC3_RS12920	COG0527	aspartate kinase activity
NC3_RS12925	COG0322	excinuclease ABC activity
NC3_RS12930	COG3118	belongs to the thioredoxin family
NC3_RS12935	COG3534	alpha-L-arabinofuranosidase
NC3_RS12940	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NC3_RS12945	COG2086	electron transfer activity
NC3_RS12950	COG1024	Enoyl-CoA hydratase
NC3_RS12955	COG1309	transcriptional regulator
NC3_RS12960	COG0318	PFAM AMP-dependent synthetase and ligase
NC3_RS12970	COG3766	membrane
NC3_RS12975	COG1193	negative regulation of DNA recombination
NC3_RS12980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NC3_RS12980	COG1796	DNA polymerase
NC3_RS12985	COG1286	toxin biosynthetic process
NC3_RS12990	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
NC3_RS12995	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NC3_RS13000	COG0072	phenylalanine-tRNA ligase activity
NC3_RS13000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NC3_RS13005	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NC3_RS13010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NC3_RS13020	COG1966	Carbon starvation protein
NC3_RS13025	COG1363	Peptidase, m42
NC3_RS13035	COG3326	Membrane
NC3_RS13040	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NC3_RS13045	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NC3_RS13050	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NC3_RS13065	COG1011	Hydrolase
NC3_RS13075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NC3_RS13085	COG0398	Pfam SNARE associated Golgi protein
NC3_RS13090	COG1484	DNA-dependent DNA replication
NC3_RS13095	COG3611	Membrane attachment protein
NC3_RS13100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NC3_RS13110	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NC3_RS13115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NC3_RS13120	COG0237	dephospho-CoA kinase activity
NC3_RS13125	COG1971	Probably functions as a manganese efflux pump
NC3_RS13130	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NC3_RS13135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NC3_RS13135	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NC3_RS13140	COG5002	protein histidine kinase activity
NC3_RS13145	COG0745	RESPONSE REGULATOR receiver
NC3_RS13150	COG0039	L-malate dehydrogenase activity
NC3_RS13155	COG0538	isocitrate dehydrogenase activity
NC3_RS13160	COG0372	Belongs to the citrate synthase family
NC3_RS13165	COG2707	UPF0756 membrane protein
NC3_RS13170	COG0628	permease
NC3_RS13175	COG3030	protein affecting phage T7 exclusion by the F plasmid
NC3_RS13185	COG0205	6-phosphofructokinase activity
NC3_RS13190	COG0825	malonyl-CoA metabolic process
NC3_RS13195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NC3_RS13200	COG0281	malic enzyme
NC3_RS13205	COG0587	DNA-directed DNA polymerase activity
NC3_RS13225	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NC3_RS13235	COG4109	DRTGG domain
NC3_RS13240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NC3_RS13245	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS13255	COG0165	Argininosuccinate lyase
NC3_RS13260	COG0137	argininosuccinate synthase activity
NC3_RS13265	COG0521	Mo-molybdopterin cofactor biosynthetic process
NC3_RS13270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NC3_RS13275	COG0827	DNA restriction-modification system
NC3_RS13280	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NC3_RS13285	COG3874	Sporulation protein YtfJ
NC3_RS13295	COG1714	RDD family
NC3_RS13300	COG0616	signal peptide processing
NC3_RS13305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NC3_RS13315	COG3239	Fatty acid desaturase
NC3_RS13320	COG4585	Histidine kinase
NC3_RS13325	COG2197	response regulator
NC3_RS13330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NC3_RS13335	COG0745	RESPONSE REGULATOR receiver
NC3_RS13340	COG2205	protein histidine kinase activity
NC3_RS13345	COG0772	Belongs to the SEDS family
NC3_RS13350	COG1695	Transcriptional regulator
NC3_RS13355	COG1136	(ABC) transporter
NC3_RS13360	COG0577	efflux transmembrane transporter activity
NC3_RS13365	COG0402	S-adenosylhomocysteine deaminase activity
NC3_RS13370	COG2249	NAD(P)H dehydrogenase (quinone) activity
NC3_RS13385	COG1279	arginine transmembrane transporter activity
NC3_RS13390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NC3_RS13400	COG0301	tRNA thio-modification
NC3_RS13405	COG1104	cysteine desulfurase activity
NC3_RS13410	COG1114	Component of the transport system for branched-chain amino acids
NC3_RS13415	COG1114	Component of the transport system for branched-chain amino acids
NC3_RS13420	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
NC3_RS13425	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NC3_RS13430	COG1309	transcriptional regulator
NC3_RS13435	COG1956	GAF domain-containing protein
NC3_RS13440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NC3_RS13455	COG1335	isochorismatase
NC3_RS13465	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NC3_RS13470	COG2329	Antibiotic biosynthesis monooxygenase
NC3_RS13475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NC3_RS13480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NC3_RS13485	COG0454	-acetyltransferase
NC3_RS13490	COG0517	IMP dehydrogenase activity
NC3_RS13495	COG0123	including yeast histone deacetylase and acetoin utilization protein
NC3_RS13500	COG1609	Transcriptional regulator
NC3_RS13505	COG1605	Chorismate mutase
NC3_RS13505	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NC3_RS13510	COG3118	belongs to the thioredoxin family
NC3_RS13515	COG4980	gas vesicle protein
NC3_RS13520	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NC3_RS13525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NC3_RS13530	COG1674	ftsk spoiiie
NC3_RS13535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NC3_RS13540	COG4848	Belongs to the UPF0354 family
NC3_RS13545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NC3_RS13560	COG1363	Peptidase, m42
NC3_RS13565	COG5584	Small secreted protein
NC3_RS13570	COG0281	malic enzyme
NC3_RS13575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NC3_RS13580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NC3_RS13590	COG0510	thiamine kinase activity
NC3_RS13595	COG1597	lipid kinase activity
NC3_RS13605	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NC3_RS13610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NC3_RS13615	COG3340	Belongs to the peptidase S51 family
NC3_RS13620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NC3_RS13625	COG2252	PERMEase
NC3_RS13630	COG1349	DNA-binding transcription factor activity
NC3_RS13635	COG1187	pseudouridine synthase activity
NC3_RS13640	COG2244	polysaccharide biosynthetic process
NC3_RS13645	COG2081	HI0933 family
NC3_RS13655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NC3_RS13660	COG3196	Protein conserved in bacteria
NC3_RS13670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NC3_RS13675	COG5578	integral membrane protein
NC3_RS13680	COG0673	inositol 2-dehydrogenase activity
NC3_RS13685	COG1653	transport
NC3_RS13690	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NC3_RS13695	COG4209	transmembrane transport
NC3_RS13700	COG2207	Transcriptional regulator
NC3_RS13705	COG1733	regulation of RNA biosynthetic process
NC3_RS13710	COG2814	Major facilitator Superfamily
NC3_RS13715	COG0656	L-ascorbic acid biosynthetic process
NC3_RS13720	COG1653	transport
NC3_RS13725	COG0395	ABC-type sugar transport system, permease component
NC3_RS13730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NC3_RS13735	COG1073	alpha beta
NC3_RS13740	COG0495	leucyl-tRNA aminoacylation
NC3_RS13750	COG1366	Belongs to the anti-sigma-factor antagonist family
NC3_RS13750	COG2202	Pas domain
NC3_RS13755	COG2433	Pfam Transposase IS66
NC3_RS13760	COG0577	efflux transmembrane transporter activity
NC3_RS13765	COG1136	(ABC) transporter
NC3_RS13775	COG1131	(ABC) transporter
NC3_RS13780	COG1725	Transcriptional regulator
NC3_RS13800	COG1242	4 iron, 4 sulfur cluster binding
NC3_RS13805	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NC3_RS13810	COG4326	sporulation control protein
NC3_RS13820	COG2267	carboxylic ester hydrolase activity
NC3_RS13825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NC3_RS13830	COG0367	asparagine synthase
NC3_RS13835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NC3_RS13840	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NC3_RS13850	COG1506	peptidase
NC3_RS13855	COG1233	COG1233 Phytoene dehydrogenase and related
NC3_RS13875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NC3_RS13880	COG1116	anion transmembrane transporter activity
NC3_RS13885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NC3_RS13890	COG0494	nUDIX hydrolase
NC3_RS13895	COG2310	stress, protein
NC3_RS13910	COG4824	toxin secretion phage lysis holin
NC3_RS13920	COG0783	Belongs to the Dps family
NC3_RS13935	COG1854	S-ribosylhomocysteine lyase activity
NC3_RS13940	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NC3_RS13945	COG0288	reversible hydration of carbon dioxide
NC3_RS13950	COG0803	Belongs to the bacterial solute-binding protein 9 family
NC3_RS13950	COG3443	Belongs to the bacterial solute-binding protein 9 family
NC3_RS13960	COG1271	oxidase subunit
NC3_RS13965	COG1294	oxidase, subunit
NC3_RS13980	COG4948	Mandelate Racemase Muconate Lactonizing
NC3_RS13985	COG0318	PFAM AMP-dependent synthetase and ligase
NC3_RS13990	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NC3_RS13995	COG0596	Alpha beta hydrolase
NC3_RS14000	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NC3_RS14005	COG1169	isochorismate synthase
NC3_RS14010	COG1575	Belongs to the MenA family. Type 1 subfamily
NC3_RS14015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NC3_RS14145	COG3859	Proton-coupled thiamine transporter YuaJ
NC3_RS14150	COG1247	-acetyltransferase
NC3_RS14155	COG3339	Conserved Protein
NC3_RS14160	COG0772	Belongs to the SEDS family
NC3_RS14165	COG0772	Belongs to the SEDS family
NC3_RS14170	COG2268	Band 7 protein
NC3_RS14175	COG1585	Membrane protein implicated in regulation of membrane protease activity
NC3_RS14180	COG2318	DinB family
NC3_RS14185	COG1454	alcohol dehydrogenase
NC3_RS14190	COG1012	belongs to the aldehyde dehydrogenase family
NC3_RS14195	COG1510	regulation of RNA biosynthetic process
NC3_RS14210	COG3409	Peptidoglycan-binding domain 1 protein
NC3_RS14210	COG5632	N-Acetylmuramoyl-L-alanine amidase
NC3_RS14245	COG3778	Protein conserved in bacteria
NC3_RS14250	COG3299	homolog of phage Mu protein gp47
NC3_RS14255	COG3628	GPW Gp25 family protein
NC3_RS14265	COG4193	domain, Protein
NC3_RS14270	COG1652	LysM domain
NC3_RS14275	COG5280	Phage tail tape measure protein TP901
NC3_RS14275	COG3953	SLT domain
NC3_RS14330	COG4653	Phage capsid family
NC3_RS14335	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NC3_RS14340	COG5518	Phage portal protein
NC3_RS14345	COG1783	phage Terminase large subunit
NC3_RS14350	COG5484	DNA packaging
NC3_RS14355	COG1595	DNA-templated transcription, initiation
NC3_RS14365	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
NC3_RS14385	COG1396	sequence-specific DNA binding
NC3_RS14395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NC3_RS14410	COG0628	permease
NC3_RS14420	COG0673	inositol 2-dehydrogenase activity
NC3_RS14425	COG0693	protein deglycase activity
NC3_RS14430	COG0840	transmembrane signaling receptor activity
NC3_RS14435	COG0840	transmembrane signaling receptor activity
NC3_RS14440	COG0840	transmembrane signaling receptor activity
NC3_RS14445	COG0840	transmembrane signaling receptor activity
NC3_RS14460	COG2070	2-Nitropropane dioxygenase
NC3_RS14465	COG0432	Pfam Uncharacterised protein family UPF0047
NC3_RS14470	COG1253	flavin adenine dinucleotide binding
NC3_RS14475	COG2738	Putative neutral zinc metallopeptidase
NC3_RS14485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NC3_RS14500	COG0166	Belongs to the GPI family
NC3_RS14505	COG1979	alcohol dehydrogenase
NC3_RS14510	COG1979	alcohol dehydrogenase
NC3_RS14515	COG2155	Conserved Protein
NC3_RS14520	COG1098	S1 RNA binding domain
NC3_RS14525	COG0436	Aminotransferase
NC3_RS14530	COG1522	sequence-specific DNA binding
NC3_RS14535	COG2267	carboxylic ester hydrolase activity
NC3_RS14545	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NC3_RS14550	COG2205	protein histidine kinase activity
NC3_RS14565	COG5018	Exonuclease
NC3_RS14570	COG2814	Major facilitator Superfamily
NC3_RS14575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NC3_RS14580	COG3011	Protein conserved in bacteria
NC3_RS14590	COG3290	protein histidine kinase activity
NC3_RS14595	COG4565	transcriptional regulatory protein
NC3_RS14600	COG1744	ABC transporter substrate-binding protein PnrA-like
NC3_RS14605	COG3845	ABC transporter
NC3_RS14610	COG4603	Belongs to the binding-protein-dependent transport system permease family
NC3_RS14615	COG1079	Belongs to the binding-protein-dependent transport system permease family
NC3_RS14620	COG3493	citrate carrier protein
NC3_RS14630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NC3_RS14630	COG2111	Na H antiporter
NC3_RS14635	COG2111	Na H antiporter
NC3_RS14640	COG1006	Multisubunit Na H antiporter MnhC subunit
NC3_RS14645	COG0651	ATP synthesis coupled electron transport
NC3_RS14650	COG1863	multisubunit Na H antiporter MnhE subunit
NC3_RS14655	COG2212	antiporter activity
NC3_RS14660	COG1320	monovalent cation:proton antiporter activity
NC3_RS14665	COG2050	protein possibly involved in aromatic compounds catabolism
NC3_RS14670	COG2197	response regulator
NC3_RS14675	COG4585	Histidine kinase
NC3_RS14685	COG0142	geranyltranstransferase activity
NC3_RS14700	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NC3_RS14705	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NC3_RS14710	COG1335	isochorismatase
NC3_RS14715	COG5506	Protein of unknown function (DUF1694)
NC3_RS14735	COG0628	permease
NC3_RS14750	COG1418	mRNA catabolic process
NC3_RS14755	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS14765	COG1511	domain protein
NC3_RS14770	COG0433	COG0433 Predicted ATPase
NC3_RS14770	COG1674	ftsk spoiiie
NC3_RS14775	COG4499	WXG100 protein secretion system (Wss), protein YukC
NC3_RS14780	COG5417	Belongs to the EsaB family
NC3_RS14785	COG4842	Belongs to the WXG100 family
NC3_RS14790	COG2508	Transcriptional regulator
NC3_RS14790	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NC3_RS14795	COG0686	Belongs to the AlaDH PNT family
NC3_RS14800	COG1268	BioY protein
NC3_RS14805	COG2056	Na+-H+ antiporter family
NC3_RS14810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NC3_RS14820	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NC3_RS14825	COG3584	3D domain protein
NC3_RS14840	COG1252	NADH dehydrogenase
NC3_RS14845	COG0492	ferredoxin-NADP+ reductase activity
NC3_RS14860	COG0316	Belongs to the HesB IscA family
NC3_RS14865	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NC3_RS14870	COG4844	belongs to the
NC3_RS14875	COG1252	NADH dehydrogenase
NC3_RS14885	COG4837	Protein of unknown function (DUF1462)
NC3_RS14895	COG1506	peptidase
NC3_RS14895	COG4946	Tricorn protease homolog
NC3_RS14895	COG0823	Involved in the tonB-independent uptake of proteins
NC3_RS14900	COG0083	homoserine kinase activity
NC3_RS14905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NC3_RS14910	COG0460	homoserine dehydrogenase
NC3_RS14915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NC3_RS14920	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NC3_RS14925	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NC3_RS14930	COG0647	UMP catabolic process
NC3_RS14935	COG2445	Protein of unknown function DUF86
NC3_RS14940	COG4470	Protein conserved in bacteria
NC3_RS14950	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NC3_RS14955	COG0739	heme binding
NC3_RS14975	COG3377	Domain of unknown function (DUF1805)
NC3_RS14980	COG0737	Belongs to the 5'-nucleotidase family
NC3_RS14985	COG1801	Protein of unknown function DUF72
NC3_RS14990	COG2508	Transcriptional regulator
NC3_RS14995	COG2140	Oxalate decarboxylase
NC3_RS15000	COG2814	Major facilitator Superfamily
NC3_RS15005	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NC3_RS15010	COG2356	endonuclease I
NC3_RS15020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC3_RS15025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC3_RS15030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NC3_RS15045	COG0561	phosphatase activity
NC3_RS15055	COG0642	Histidine kinase
NC3_RS15055	COG5002	protein histidine kinase activity
NC3_RS15060	COG0745	RESPONSE REGULATOR receiver
NC3_RS15065	COG2311	Membrane
NC3_RS15075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NC3_RS15085	COG1309	transcriptional regulator
NC3_RS15105	COG0719	Fe-S assembly protein
NC3_RS15110	COG0822	iron-sulfur transferase activity
NC3_RS15115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NC3_RS15120	COG0719	Fe-S assembly protein
NC3_RS15125	COG0396	ATPase activity
NC3_RS15130	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NC3_RS15135	COG1464	Belongs to the NlpA lipoprotein family
NC3_RS15140	COG2011	ABC-type metal ion transport system permease component
NC3_RS15145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NC3_RS15155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NC3_RS15160	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NC3_RS15170	COG0509	glycine decarboxylation via glycine cleavage system
NC3_RS15175	COG1393	Belongs to the ArsC family
NC3_RS15180	COG1960	acyl-CoA dehydrogenase activity
NC3_RS15185	COG0183	Belongs to the thiolase family
NC3_RS15190	COG1024	Enoyl-CoA hydratase
NC3_RS15190	COG1250	3-hydroxyacyl-CoA dehydrogenase
NC3_RS15205	COG5577	PFAM Coat F domain
NC3_RS15215	COG1120	ATPase activity
NC3_RS15225	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS15230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NC3_RS15235	COG0745	RESPONSE REGULATOR receiver
NC3_RS15240	COG2205	protein histidine kinase activity
NC3_RS15240	COG2770	Histidine kinase
NC3_RS15250	COG1309	transcriptional regulator
NC3_RS15255	COG0114	fumarate hydratase activity
NC3_RS15265	COG0697	spore germination
NC3_RS15270	COG0814	amino acid
NC3_RS15285	COG2197	response regulator
NC3_RS15290	COG4585	Histidine kinase
NC3_RS15295	COG4758	membrane
NC3_RS15305	COG1842	Phage shock protein A
NC3_RS15310	COG4758	membrane
NC3_RS15315	COG2096	Adenosyltransferase
NC3_RS15320	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS15325	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NC3_RS15335	COG3604	Transcriptional regulator
NC3_RS15350	COG1454	alcohol dehydrogenase
NC3_RS15355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NC3_RS15360	COG1120	ATPase activity
NC3_RS15365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC3_RS15370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NC3_RS15380	COG2721	sulfolactate sulfo-lyase activity
NC3_RS15385	COG0246	Mannitol dehydrogenase
NC3_RS15390	COG1609	Transcriptional regulator
NC3_RS15395	COG1904	glucuronate isomerase
NC3_RS15400	COG2205	protein histidine kinase activity
NC3_RS15405	COG0745	RESPONSE REGULATOR receiver
NC3_RS15410	COG1120	ATPase activity
NC3_RS15415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC3_RS15420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC3_RS15425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NC3_RS15430	COG0531	amino acid
NC3_RS15445	COG1988	membrane-bound metal-dependent
NC3_RS15450	COG1368	sulfuric ester hydrolase activity
NC3_RS15455	COG0725	ABC transporter, periplasmic molybdate-binding protein
NC3_RS15460	COG4149	molybdate abc transporter
NC3_RS15465	COG0656	L-ascorbic acid biosynthetic process
NC3_RS15470	COG1940	carbohydrate kinase activity
NC3_RS15475	COG0025	NhaP-type Na H and K H
NC3_RS15480	COG2860	membrane
NC3_RS15485	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NC3_RS15490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NC3_RS15495	COG2217	Heavy metal translocating P-type atpase
NC3_RS15500	COG1121	(ABC) transporter
NC3_RS15505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NC3_RS15510	COG0803	Belongs to the bacterial solute-binding protein 9 family
NC3_RS15520	COG3226	Transcriptional regulator
NC3_RS15525	COG0784	Response regulator, receiver
NC3_RS15530	COG4191	Histidine kinase
NC3_RS15535	COG1027	Aspartate ammonia-lyase
NC3_RS15550	COG2217	Heavy metal translocating P-type atpase
NC3_RS15555	COG2608	mercury ion transmembrane transporter activity
NC3_RS15560	COG1937	Protein conserved in bacteria
NC3_RS15580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NC3_RS15590	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NC3_RS15595	COG0557	exoribonuclease II activity
NC3_RS15600	COG1647	Serine aminopeptidase, S33
NC3_RS15605	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NC3_RS15610	COG2002	toxin-antitoxin pair type II binding
NC3_RS15615	COG1476	TRANSCRIPTIONal
NC3_RS15620	COG1396	sequence-specific DNA binding
NC3_RS15625	COG1396	sequence-specific DNA binding
NC3_RS15630	COG1733	regulation of RNA biosynthetic process
NC3_RS15635	COG1174	glycine betaine transport
NC3_RS15640	COG1732	Glycine betaine
NC3_RS15645	COG1174	glycine betaine transport
NC3_RS15650	COG1125	glycine betaine transport
NC3_RS15650	COG0517	IMP dehydrogenase activity
NC3_RS15655	COG1510	regulation of RNA biosynthetic process
NC3_RS15660	COG2095	MarC family integral membrane protein
NC3_RS15670	COG0456	acetyltransferase
NC3_RS15690	COG1131	(ABC) transporter
NC3_RS15700	COG0148	phosphopyruvate hydratase activity
NC3_RS15705	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NC3_RS15710	COG0149	triose-phosphate isomerase activity
NC3_RS15715	COG0126	phosphoglycerate kinase activity
NC3_RS15720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NC3_RS15725	COG2390	Transcriptional regulator
NC3_RS15730	COG0833	amino acid
NC3_RS15735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NC3_RS15740	COG3829	transcription factor binding
NC3_RS15745	COG2186	Transcriptional regulator
NC3_RS15750	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NC3_RS15760	COG0534	Mate efflux family protein
NC3_RS15765	COG4608	Belongs to the ABC transporter superfamily
NC3_RS15770	COG0444	Belongs to the ABC transporter superfamily
NC3_RS15775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC3_RS15780	COG0601	transmembrane transport
NC3_RS15785	COG0747	negative chemotaxis
NC3_RS15790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NC3_RS15795	COG0110	maltose O-acetyltransferase activity
NC3_RS15800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NC3_RS15805	COG2244	polysaccharide biosynthetic process
NC3_RS15810	COG5039	Polysaccharide pyruvyl transferase
NC3_RS15815	COG1216	Glycosyl transferase, family 2
NC3_RS15825	COG0438	transferase activity, transferring glycosyl groups
NC3_RS15830	COG1215	transferase activity, transferring glycosyl groups
NC3_RS15835	COG0438	transferase activity, transferring glycosyl groups
NC3_RS15840	COG1086	Polysaccharide biosynthesis protein
NC3_RS15845	COG0489	protein tyrosine kinase activity
NC3_RS15850	COG3944	biosynthesis protein
NC3_RS15855	COG1396	sequence-specific DNA binding
NC3_RS15865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NC3_RS15870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC3_RS15875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC3_RS15880	COG0726	polysaccharide deacetylase
NC3_RS15885	COG0488	(ABC) transporter
NC3_RS15905	COG0601	transmembrane transport
NC3_RS15910	COG0747	negative chemotaxis
NC3_RS15915	COG1819	glycosyl
NC3_RS15930	COG0740	serine-type endopeptidase activity
NC3_RS15935	COG1611	Belongs to the LOG family
NC3_RS15940	COG1694	Mazg nucleotide pyrophosphohydrolase
NC3_RS15945	COG0659	secondary active sulfate transmembrane transporter activity
NC3_RS15950	COG0288	reversible hydration of carbon dioxide
NC3_RS15955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NC3_RS15965	COG2162	N-hydroxyarylamine O-acetyltransferase activity
NC3_RS15970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC3_RS15975	COG1481	regulation of sporulation
NC3_RS15980	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NC3_RS15985	COG1660	Displays ATPase and GTPase activities
NC3_RS15990	COG1051	belongs to the nudix hydrolase family
NC3_RS15995	COG0492	ferredoxin-NADP+ reductase activity
NC3_RS16000	COG0791	NLP P60 protein
NC3_RS16000	COG3883	PFAM NLP P60 protein
NC3_RS16005	COG0457	Tetratricopeptide repeat
NC3_RS16010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NC3_RS16010	COG0140	phosphoribosyl-ATP diphosphatase activity
NC3_RS16015	COG0107	imidazoleglycerol-phosphate synthase activity
NC3_RS16020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NC3_RS16025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NC3_RS16030	COG0131	Imidazoleglycerol-phosphate dehydratase
NC3_RS16035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NC3_RS16040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NC3_RS16045	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NC3_RS16050	COG4990	cell redox homeostasis
NC3_RS16065	COG2910	NAD(P)H-binding
NC3_RS16070	COG1959	2 iron, 2 sulfur cluster binding
NC3_RS16075	COG0110	maltose O-acetyltransferase activity
NC3_RS16080	COG0546	phosphoglycolate phosphatase activity
NC3_RS16085	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NC3_RS16095	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NC3_RS16100	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NC3_RS16105	COG0363	glucosamine-6-phosphate deaminase activity
NC3_RS16110	COG2188	Transcriptional regulator
NC3_RS16115	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NC3_RS16120	COG1950	PFAM Membrane protein of
NC3_RS16125	COG1983	PspC domain protein
NC3_RS16130	COG3595	metallopeptidase activity
NC3_RS16145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NC3_RS16155	COG4897	Protein conserved in bacteria
NC3_RS16160	COG0574	Belongs to the PEP-utilizing enzyme family
NC3_RS16160	COG3848	Pyruvate phosphate dikinase
NC3_RS16165	COG1309	transcriptional regulator
NC3_RS16170	COG2814	Major facilitator Superfamily
NC3_RS16180	COG0745	RESPONSE REGULATOR receiver
NC3_RS16185	COG5002	protein histidine kinase activity
NC3_RS16190	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NC3_RS16195	COG0463	Glycosyl transferase, family 2
NC3_RS16200	COG1113	amino acid transport
NC3_RS16205	COG0778	Nitroreductase
NC3_RS16210	COG1733	regulation of RNA biosynthetic process
NC3_RS16215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NC3_RS16225	COG0793	Belongs to the peptidase S41A family
NC3_RS16225	COG3409	Peptidoglycan-binding domain 1 protein
NC3_RS16230	COG0730	response to heat
NC3_RS16235	COG0791	NLP P60 protein
NC3_RS16235	COG3883	PFAM NLP P60 protein
NC3_RS16240	COG2177	Part of the ABC transporter FtsEX involved in
NC3_RS16245	COG2884	Cell division ATP-binding protein ftsE
NC3_RS16250	COG2010	Cytochrome c
NC3_RS16255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NC3_RS16275	COG0653	protein targeting
NC3_RS16280	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NC3_RS16285	COG0840	transmembrane signaling receptor activity
NC3_RS16300	COG1516	flagellar protein fliS
NC3_RS16305	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NC3_RS16310	COG1334	flagellar protein FlaG
NC3_RS16315	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NC3_RS16320	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
NC3_RS16330	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NC3_RS16335	COG1256	bacterial-type flagellum assembly
NC3_RS16335	COG4786	Flagellar basal body rod
NC3_RS16340	COG3418	PFAM FlgN family protein
NC3_RS16355	COG1040	competence protein
NC3_RS16365	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NC3_RS16370	COG1307	EDD domain protein, DegV family
NC3_RS16375	COG2197	response regulator
NC3_RS16380	COG4585	Histidine kinase
NC3_RS16385	COG1739	Uncharacterized protein family UPF0029
NC3_RS16390	COG1316	TRANSCRIPTIONal
NC3_RS16395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NC3_RS16400	COG0438	transferase activity, transferring glycosyl groups
NC3_RS16405	COG1215	transferase activity, transferring glycosyl groups
NC3_RS16410	COG3206	protein involved in exopolysaccharide biosynthesis
NC3_RS16415	COG3307	-O-antigen
NC3_RS16420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NC3_RS16425	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NC3_RS16430	COG0438	transferase activity, transferring glycosyl groups
NC3_RS16430	COG0297	glycogen (starch) synthase activity
NC3_RS16435	COG2244	polysaccharide biosynthetic process
NC3_RS16450	COG0860	N-Acetylmuramoyl-L-alanine amidase
NC3_RS16450	COG2247	cell wall binding repeat
NC3_RS16455	COG0860	N-Acetylmuramoyl-L-alanine amidase
NC3_RS16455	COG2247	cell wall binding repeat
NC3_RS16460	COG2247	cell wall binding repeat
NC3_RS16460	COG2385	sporulation resulting in formation of a cellular spore
NC3_RS16470	COG1316	TRANSCRIPTIONal
NC3_RS16495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NC3_RS16500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NC3_RS16505	COG1134	teichoic acid transport
NC3_RS16510	COG1682	transport, permease protein
NC3_RS16525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NC3_RS16530	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NC3_RS16535	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NC3_RS16540	COG4193	domain, Protein
NC3_RS16545	COG1482	cell wall glycoprotein biosynthetic process
NC3_RS16555	COG1175	transmembrane transport
NC3_RS16560	COG1653	transport
NC3_RS16565	COG2197	response regulator
NC3_RS16570	COG2972	Histidine kinase
NC3_RS16580	COG0454	-acetyltransferase
NC3_RS16585	COG0800	Aldolase
NC3_RS16590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NC3_RS16595	COG1609	Transcriptional regulator
NC3_RS16600	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NC3_RS16605	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS16610	COG0697	spore germination
NC3_RS16615	COG0814	amino acid
NC3_RS16630	COG2814	Major facilitator Superfamily
NC3_RS16635	COG1316	TRANSCRIPTIONal
NC3_RS16640	COG0561	phosphatase activity
NC3_RS16645	COG0791	NLP P60 protein
NC3_RS16655	COG2843	Capsule synthesis protein
NC3_RS16665	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NC3_RS16670	COG0697	spore germination
NC3_RS16685	COG1609	Transcriptional regulator
NC3_RS16690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NC3_RS16695	COG1869	D-ribose catabolic process
NC3_RS16700	COG1129	ABC transporter
NC3_RS16705	COG1172	Belongs to the binding-protein-dependent transport system permease family
NC3_RS16710	COG1879	ABC-type sugar transport system periplasmic component
NC3_RS16715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NC3_RS16720	COG0583	DNA-binding transcription factor activity
NC3_RS16725	COG0028	Belongs to the TPP enzyme family
NC3_RS16730	COG3527	Alpha-acetolactate decarboxylase
NC3_RS16735	COG1522	sequence-specific DNA binding
NC3_RS16740	COG2059	Chromate
NC3_RS16745	COG2059	Chromate
NC3_RS16750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NC3_RS16760	COG4715	Zinc finger, swim domain protein
NC3_RS16765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NC3_RS16770	COG2202	Pas domain
NC3_RS16770	COG1366	Belongs to the anti-sigma-factor antagonist family
NC3_RS16775	COG0561	phosphatase activity
NC3_RS16790	COG1970	mechanosensitive ion channel activity
NC3_RS16795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NC3_RS16800	COG0457	Tetratricopeptide repeat
NC3_RS16805	COG4786	Flagellar basal body rod
NC3_RS16810	COG4786	Flagellar basal body rod
NC3_RS16815	COG1077	Cell shape determining protein MreB Mrl
NC3_RS16820	COG1609	Transcriptional regulator
NC3_RS16825	COG1846	Transcriptional regulator
NC3_RS16830	COG2814	Major facilitator Superfamily
NC3_RS16835	COG0671	phosphoesterase, PA-phosphatase related
NC3_RS16840	COG0477	Major facilitator Superfamily
NC3_RS16845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC3_RS16850	COG0765	amino acid transport
NC3_RS16855	COG1126	abc transporter atp-binding protein
NC3_RS16860	COG0004	ammonium transporteR
NC3_RS16865	COG0347	Belongs to the P(II) protein family
NC3_RS16870	COG0739	heme binding
NC3_RS16875	COG1247	-acetyltransferase
NC3_RS16910	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NC3_RS16915	COG0523	cobalamin synthesis protein
NC3_RS16920	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NC3_RS16925	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NC3_RS16930	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NC3_RS16935	COG2223	nitrite transmembrane transporter activity
NC3_RS16945	COG2304	oxidoreductase activity
NC3_RS16950	COG2304	oxidoreductase activity
NC3_RS16955	COG2385	sporulation resulting in formation of a cellular spore
NC3_RS16960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NC3_RS16970	COG4836	Membrane
NC3_RS16980	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NC3_RS16985	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NC3_RS16990	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NC3_RS16995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NC3_RS17000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NC3_RS17005	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NC3_RS17010	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NC3_RS17015	COG0356	it plays a direct role in the translocation of protons across the membrane
NC3_RS17025	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NC3_RS17030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NC3_RS17035	COG4475	Protein of unknown function (DUF436)
NC3_RS17040	COG0698	ribose 5-phosphate isomerase
NC3_RS17045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NC3_RS17050	COG1971	Probably functions as a manganese efflux pump
NC3_RS17055	COG0009	L-threonylcarbamoyladenylate synthase
NC3_RS17060	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NC3_RS17075	COG2890	protein-(glutamine-N5) methyltransferase activity
NC3_RS17080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NC3_RS17085	COG0789	Transcriptional regulator
NC3_RS17090	COG0679	Auxin Efflux Carrier
NC3_RS17095	COG0281	malic enzyme
NC3_RS17100	COG1435	thymidine kinase activity
NC3_RS17105	COG0254	rRNA binding
NC3_RS17110	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NC3_RS17115	COG1494	fructose-1,6-bisphosphatase
NC3_RS17120	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NC3_RS17125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NC3_RS17130	COG0191	fructose-bisphosphate aldolase activity
NC3_RS17135	COG2204	response regulator
NC3_RS17140	COG4821	SIS domain
NC3_RS17145	COG0504	CTP synthase activity
NC3_RS17150	COG3343	RNA polymerase activity
NC3_RS17165	COG1960	acyl-CoA dehydrogenase activity
NC3_RS17170	COG1960	acyl-CoA dehydrogenase activity
NC3_RS17175	COG1250	3-hydroxyacyl-CoA dehydrogenase
NC3_RS17180	COG0183	Belongs to the thiolase family
NC3_RS17185	COG0247	lactate metabolic process
NC3_RS17185	COG2181	nitrate reductase activity
NC3_RS17190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NC3_RS17195	COG4294	response to UV
NC3_RS17205	COG1619	proteins homologs of microcin C7 resistance protein MccF
NC3_RS17215	COG1132	(ABC) transporter
NC3_RS17220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NC3_RS17225	COG1619	proteins homologs of microcin C7 resistance protein MccF
NC3_RS17230	COG0018	arginyl-trna synthetase
NC3_RS17235	COG4506	Protein conserved in bacteria
NC3_RS17245	COG0010	Belongs to the arginase family
NC3_RS17250	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NC3_RS17255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NC3_RS17265	COG1994	Peptidase M50
NC3_RS17270	COG1942	4-Oxalocrotonate Tautomerase
NC3_RS17280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NC3_RS17285	COG0583	DNA-binding transcription factor activity
NC3_RS17290	COG0431	NADPH-dependent FMN reductase
NC3_RS17295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NC3_RS17300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NC3_RS17305	COG0454	-acetyltransferase
NC3_RS17310	COG0765	amino acid transport
NC3_RS17320	COG0765	amino acid transport
NC3_RS17325	COG1126	abc transporter atp-binding protein
NC3_RS17330	COG3465	dGTPase activity
NC3_RS17335	COG1078	dGTPase activity
NC3_RS17340	COG4844	belongs to the
NC3_RS17400	COG5444	nuclease activity
NC3_RS17430	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NC3_RS17440	COG0280	phosphate acetyltransferase
NC3_RS17450	COG2814	Major facilitator Superfamily
NC3_RS17455	COG1522	sequence-specific DNA binding
NC3_RS17460	COG2814	Major facilitator Superfamily
NC3_RS17465	COG0077	Prephenate dehydratase
NC3_RS17470	COG1917	Cupin 2, conserved barrel domain protein
NC3_RS17475	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS17480	COG0151	Belongs to the GarS family
NC3_RS17485	COG0436	Aminotransferase
NC3_RS17490	COG1028	Short-chain dehydrogenase reductase Sdr
NC3_RS17495	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
NC3_RS17500	COG1091	dTDP-4-dehydrorhamnose reductase activity
NC3_RS17505	COG1088	dTDP-glucose 4,6-dehydratase activity
NC3_RS17510	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NC3_RS17515	COG3980	spore coat polysaccharide biosynthesis protein
NC3_RS17520	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
NC3_RS17525	COG2089	acid synthase
NC3_RS17530	COG0456	acetyltransferase
NC3_RS17535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NC3_RS17540	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NC3_RS17545	COG0463	Glycosyl transferase, family 2
NC3_RS17565	COG2363	Small membrane protein
NC3_RS17570	COG2233	PERMEase
NC3_RS17580	COG1012	belongs to the aldehyde dehydrogenase family
NC3_RS17585	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NC3_RS17590	COG1216	Glycosyl transferase, family 2
NC3_RS17600	COG0351	phosphomethylpyrimidine kinase
NC3_RS17635	COG1621	beta-fructofuranosidase activity
NC3_RS17640	COG1263	PTS System
NC3_RS17640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC3_RS17645	COG3711	transcriptional antiterminator
NC3_RS17655	COG1404	Belongs to the peptidase S8 family
NC3_RS17665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NC3_RS17670	COG0778	Nitroreductase
NC3_RS17675	COG0772	Belongs to the SEDS family
NC3_RS17685	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NC3_RS17690	COG1845	cytochrome c oxidase, subunit III
NC3_RS17695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NC3_RS17700	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NC3_RS17710	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
NC3_RS17715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NC3_RS17720	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NC3_RS17735	COG2246	polysaccharide biosynthetic process
NC3_RS17755	COG3162	membrane
NC3_RS17760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NC3_RS17775	COG0352	thiamine-phosphate diphosphorylase activity
NC3_RS17780	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NC3_RS17785	COG0583	DNA-binding transcription factor activity
NC3_RS17790	COG1380	Effector of murein hydrolase LrgA
NC3_RS17795	COG1346	cytolysis
NC3_RS17800	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NC3_RS17805	COG0346	lactoylglutathione lyase activity
NC3_RS17815	COG0765	amino acid transport
NC3_RS17820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC3_RS17825	COG0457	Tetratricopeptide repeat
NC3_RS17835	COG2357	RelA SpoT domain protein
NC3_RS17840	COG1172	Belongs to the binding-protein-dependent transport system permease family
NC3_RS17845	COG1129	ABC transporter
NC3_RS17855	COG3420	alginic acid biosynthetic process
NC3_RS17860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NC3_RS17870	COG1486	melibiose metabolic process
NC3_RS17875	COG1447	Phosphotransferase system cellobiose-specific component IIA
NC3_RS17880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NC3_RS17885	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NC3_RS17890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC3_RS17890	COG3711	transcriptional antiterminator
NC3_RS17910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NC3_RS17925	COG1595	DNA-templated transcription, initiation
NC3_RS17935	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NC3_RS17940	COG4988	ABC transporter
NC3_RS17945	COG1294	oxidase, subunit
NC3_RS17950	COG1271	oxidase subunit
NC3_RS17965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC3_RS17970	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NC3_RS17975	COG4509	Sortase family
NC3_RS18000	COG5386	Cell surface protein
NC3_RS18005	COG5386	Cell surface protein
NC3_RS18010	COG1733	regulation of RNA biosynthetic process
NC3_RS18015	COG2514	catechol 2,3-dioxygenase activity
NC3_RS18020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NC3_RS18020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NC3_RS18025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NC3_RS18025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NC3_RS18035	COG0726	polysaccharide deacetylase
NC3_RS18040	COG1447	Phosphotransferase system cellobiose-specific component IIA
NC3_RS18045	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NC3_RS18050	COG2723	6-phospho-beta-galactosidase activity
NC3_RS18055	COG1312	Catalyzes the dehydration of D-mannonate
NC3_RS18060	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NC3_RS18065	COG3711	transcriptional antiterminator
NC3_RS18065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC3_RS18090	COG1757	Na H antiporter
NC3_RS18095	COG1027	Aspartate ammonia-lyase
NC3_RS18100	COG0252	asparaginase activity
NC3_RS18105	COG1396	sequence-specific DNA binding
NC3_RS18130	COG4842	Belongs to the WXG100 family
NC3_RS18135	COG2195	Cleaves the N-terminal amino acid of tripeptides
NC3_RS18150	COG1737	Transcriptional regulator
NC3_RS18155	COG2084	Dehydrogenase
NC3_RS18165	COG2610	gluconate transmembrane transporter activity
NC3_RS18170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NC3_RS18180	COG1136	(ABC) transporter
NC3_RS18185	COG2723	6-phospho-beta-galactosidase activity
NC3_RS18190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC3_RS18190	COG1263	PTS System
NC3_RS18190	COG2190	(PTS) system
NC3_RS18195	COG3711	transcriptional antiterminator
NC3_RS18200	COG3878	Protein conserved in bacteria
NC3_RS18210	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NC3_RS18215	COG1122	ATPase activity
NC3_RS18220	COG4721	ABC-type cobalt transport system, permease component
NC3_RS18225	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NC3_RS18260	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NC3_RS18265	COG0778	Nitroreductase
NC3_RS18270	COG1846	Transcriptional regulator
NC3_RS18275	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NC3_RS18280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NC3_RS18285	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NC3_RS18290	COG2390	Transcriptional regulator
NC3_RS18300	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NC3_RS18300	COG2755	lipolytic protein G-D-S-L family
NC3_RS18305	COG0477	Major facilitator Superfamily
NC3_RS18310	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NC3_RS18315	COG2226	methyltransferase
NC3_RS18325	COG0561	phosphatase activity
NC3_RS18330	COG0789	Transcriptional regulator
NC3_RS18335	COG0673	inositol 2-dehydrogenase activity
NC3_RS18340	COG0840	transmembrane signaling receptor activity
NC3_RS18345	COG1113	amino acid transport
NC3_RS18350	COG4335	DNA alkylation repair
NC3_RS18360	COG1070	Carbohydrate kinase
NC3_RS18365	COG1737	Transcriptional regulator
NC3_RS18405	COG0583	DNA-binding transcription factor activity
NC3_RS18410	COG1609	Transcriptional regulator
NC3_RS18415	COG2182	Extracellular solute-binding protein
NC3_RS18420	COG1175	transmembrane transport
NC3_RS18425	COG3833	ABC-type maltose transport systems, permease component
NC3_RS18435	COG1874	Beta-galactosidase
NC3_RS18440	COG2851	Citrate transporter
NC3_RS18450	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NC3_RS18455	COG1131	(ABC) transporter
NC3_RS18460	COG2824	Alkylphosphonate utilization operon protein PhnA
NC3_RS18470	COG1929	Belongs to the glycerate kinase type-1 family
NC3_RS18475	COG2610	gluconate transmembrane transporter activity
NC3_RS18480	COG3835	regulator
NC3_RS18485	COG1309	transcriptional regulator
NC3_RS18490	COG2814	Major facilitator Superfamily
NC3_RS18500	COG1136	(ABC) transporter
NC3_RS18510	COG0457	Tetratricopeptide repeat
NC3_RS18515	COG3711	transcriptional antiterminator
NC3_RS18520	COG2723	6-phospho-beta-galactosidase activity
NC3_RS18525	COG2190	(PTS) system
NC3_RS18525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC3_RS18525	COG1263	PTS System
NC3_RS18550	COG0494	nUDIX hydrolase
NC3_RS18565	COG1113	amino acid transport
NC3_RS18570	COG1609	Transcriptional regulator
NC3_RS18575	COG2814	Major facilitator Superfamily
NC3_RS18580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NC3_RS18585	COG2814	Major facilitator Superfamily
NC3_RS18635	COG5444	nuclease activity
NC3_RS18650	COG2723	6-phospho-beta-galactosidase activity
NC3_RS18660	COG2188	Transcriptional regulator
NC3_RS18670	COG0384	phenazine biosynthesis protein PhzF
NC3_RS18675	COG0583	DNA-binding transcription factor activity
NC3_RS18695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NC3_RS18710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NC3_RS18730	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NC3_RS18740	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NC3_RS18750	COG4720	Psort location CytoplasmicMembrane, score
NC3_RS18770	COG0456	acetyltransferase
NC3_RS18775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NC3_RS18780	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NC3_RS18785	COG4853	Protein conserved in bacteria
NC3_RS18790	COG4863	YycH protein
NC3_RS18795	COG5002	protein histidine kinase activity
NC3_RS18800	COG0745	RESPONSE REGULATOR receiver
NC3_RS18825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NC3_RS18835	COG2311	Membrane
NC3_RS18840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NC3_RS18850	COG0346	lactoylglutathione lyase activity
NC3_RS18855	COG0305	Participates in initiation and elongation during chromosome replication
NC3_RS18870	COG2819	hydrolase of the alpha beta superfamily
NC3_RS18875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NC3_RS18875	COG2207	Transcriptional regulator
NC3_RS18880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NC3_RS18885	COG2819	hydrolase of the alpha beta superfamily
NC3_RS18890	COG3093	addiction module antidote protein HigA
NC3_RS18895	COG2807	transmembrane transport
NC3_RS18900	COG0359	binds to the 23S rRNA
NC3_RS18905	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
NC3_RS18910	COG4241	membrane
NC3_RS18915	COG1227	inorganic diphosphatase activity
NC3_RS18925	COG1595	DNA-templated transcription, initiation
NC3_RS18935	COG0753	catalase activity
NC3_RS18940	COG0655	NAD(P)H dehydrogenase (quinone) activity
NC3_RS18945	COG0400	carboxylic ester hydrolase activity
NC3_RS18950	COG0346	lactoylglutathione lyase activity
NC3_RS18955	COG1174	glycine betaine transport
NC3_RS18960	COG0517	IMP dehydrogenase activity
NC3_RS18960	COG1125	glycine betaine transport
NC3_RS18965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NC3_RS18970	COG0629	single-stranded DNA binding
NC3_RS18975	COG0360	Binds together with S18 to 16S ribosomal RNA
NC3_RS18980	COG0012	GTP binding
NC3_RS18985	COG4481	Protein conserved in bacteria
NC3_RS19000	COG3949	Membrane
NC3_RS19010	COG1475	DNA binding
NC3_RS19015	COG1192	Involved in chromosome partitioning
NC3_RS19025	COG1475	DNA binding
NC3_RS19030	COG0357	Ribosomal RNA small subunit methyltransferase G
NC3_RS19035	COG0445	tRNA wobble uridine modification
NC3_RS19040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NC3_RS19045	COG1847	R3H domain protein
NC3_RS19050	COG0706	membrane insertase activity
NC3_RS19055	COG0594	ribonuclease P activity
NC3_RS19060	COG0230	Belongs to the bacterial ribosomal protein bL34 family