locus-tag	class	description
G4D59_RS00020	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
G4D59_RS00025	COG3853	Toxic anion resistance protein (TelA)
G4D59_RS00030	COG1982	Orn Lys Arg decarboxylase major
G4D59_RS00035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4D59_RS00040	COG3870	Protein conserved in bacteria
G4D59_RS00045	COG1728	Protein conserved in bacteria
G4D59_RS00050	COG0470	DNA polymerase III
G4D59_RS00055	COG1774	PSP1 C-terminal conserved region
G4D59_RS00060	COG4467	Involved in initiation control of chromosome replication
G4D59_RS00065	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
G4D59_RS00070	COG2827	Endonuclease containing a URI domain
G4D59_RS00075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G4D59_RS00080	COG2002	toxin-antitoxin pair type II binding
G4D59_RS00085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4D59_RS00085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4D59_RS00090	COG0084	hydrolase, TatD family'
G4D59_RS00095	COG3583	domain protein
G4D59_RS00095	COG3584	3D domain protein
G4D59_RS00100	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
G4D59_RS00105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G4D59_RS00115	COG4466	Protein conserved in bacteria
G4D59_RS00125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G4D59_RS00130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G4D59_RS00135	COG0251	oxidation-reduction process
G4D59_RS00140	COG2088	sporulation resulting in formation of a cellular spore
G4D59_RS00150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G4D59_RS00155	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G4D59_RS00160	COG0193	aminoacyl-tRNA hydrolase activity
G4D59_RS00170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G4D59_RS00175	COG2002	toxin-antitoxin pair type II binding
G4D59_RS00180	COG2244	polysaccharide biosynthetic process
G4D59_RS00185	COG3956	TIGRFAM MazG family protein
G4D59_RS00190	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G4D59_RS00205	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G4D59_RS00210	COG1098	S1 RNA binding domain
G4D59_RS00225	COG2208	phosphoserine phosphatase activity
G4D59_RS00230	COG2304	oxidoreductase activity
G4D59_RS00235	COG0515	serine threonine protein kinase
G4D59_RS00240	COG0037	tRNA processing
G4D59_RS00245	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
G4D59_RS00250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4D59_RS00255	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G4D59_RS00260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G4D59_RS00265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4D59_RS00270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4D59_RS00275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G4D59_RS00280	COG0512	Glutamine amidotransferase of anthranilate synthase
G4D59_RS00285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4D59_RS00290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G4D59_RS00295	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G4D59_RS00300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G4D59_RS00305	COG1396	sequence-specific DNA binding
G4D59_RS00310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4D59_RS00315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G4D59_RS00395	COG4463	regulation of RNA biosynthetic process
G4D59_RS00400	COG3880	PFAM UvrB UvrC protein
G4D59_RS00405	COG3869	Catalyzes the specific phosphorylation of arginine residues in
G4D59_RS00410	COG0542	response to heat
G4D59_RS00415	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
G4D59_RS00420	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
G4D59_RS00425	COG4956	integral membrane protein (PIN domain superfamily)
G4D59_RS00430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G4D59_RS00435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G4D59_RS00440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G4D59_RS00445	COG1045	serine acetyltransferase
G4D59_RS00450	COG0215	cysteine-tRNA ligase activity
G4D59_RS00455	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
G4D59_RS00460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4D59_RS00465	COG3688	RNA-binding protein containing a PIN domain
G4D59_RS00470	COG1595	DNA-templated transcription, initiation
G4D59_RS00475	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G4D59_RS00480	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G4D59_RS00485	COG0250	Participates in transcription elongation, termination and antitermination
G4D59_RS00495	COG0081	regulation of translation
G4D59_RS00500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G4D59_RS00505	COG0222	ribosome binding
G4D59_RS00510	COG2813	Specifically methylates the guanine in position
G4D59_RS00515	COG0085	RNA polymerase activity
G4D59_RS00520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G4D59_RS00525	COG1358	cellular component organization or biogenesis
G4D59_RS00530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G4D59_RS00535	COG0049	tRNA binding
G4D59_RS00540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G4D59_RS00545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G4D59_RS00550	COG0596	Alpha beta hydrolase
G4D59_RS00560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G4D59_RS00565	COG0088	Forms part of the polypeptide exit tunnel
G4D59_RS00570	COG0089	rRNA binding
G4D59_RS00575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G4D59_RS00580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G4D59_RS00585	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G4D59_RS00590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G4D59_RS00595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G4D59_RS00600	COG0255	Belongs to the universal ribosomal protein uL29 family
G4D59_RS00605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G4D59_RS00610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G4D59_RS00615	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G4D59_RS00620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G4D59_RS00625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G4D59_RS00630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G4D59_RS00635	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G4D59_RS00640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G4D59_RS00645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G4D59_RS00650	COG1841	ribosomal large subunit assembly
G4D59_RS00655	COG0200	Binds to the 23S rRNA
G4D59_RS00660	COG0201	protein transport
G4D59_RS00665	COG0563	adenylate kinase activity
G4D59_RS00670	COG0024	Methionine aminopeptidase
G4D59_RS00675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G4D59_RS00680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G4D59_RS00685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G4D59_RS00690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G4D59_RS00695	COG0202	RNA polymerase activity
G4D59_RS00700	COG0203	ribosomal protein L17
G4D59_RS00705	COG1122	ATPase activity
G4D59_RS00710	COG1122	ATPase activity
G4D59_RS00715	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G4D59_RS00720	COG0101	tRNA pseudouridine synthase activity
G4D59_RS00725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G4D59_RS00730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G4D59_RS00735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4D59_RS00760	COG1136	(ABC) transporter
G4D59_RS00780	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4D59_RS00785	COG0489	protein tyrosine kinase activity
G4D59_RS00795	COG2194	sulfuric ester hydrolase activity
G4D59_RS00800	COG0726	polysaccharide deacetylase
G4D59_RS00830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G4D59_RS00835	COG0659	secondary active sulfate transmembrane transporter activity
G4D59_RS00840	COG0385	Bile acid
G4D59_RS00845	COG3876	Protein conserved in bacteria
G4D59_RS00850	COG1472	Belongs to the glycosyl hydrolase 3 family
G4D59_RS00855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G4D59_RS00860	COG1263	PTS System
G4D59_RS00860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4D59_RS00865	COG1737	Transcriptional regulator
G4D59_RS00870	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
G4D59_RS00905	COG1595	DNA-templated transcription, initiation
G4D59_RS00910	COG5662	AntiSigma factor
G4D59_RS00915	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
G4D59_RS00920	COG4856	YbbR-like protein
G4D59_RS00925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4D59_RS00930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4D59_RS00950	COG1131	(ABC) transporter
G4D59_RS00960	COG1136	(ABC) transporter
G4D59_RS00970	COG1695	Transcriptional regulator
G4D59_RS00985	COG0535	radical SAM domain protein
G4D59_RS00990	COG1266	CAAX protease self-immunity
G4D59_RS00995	COG1131	(ABC) transporter
G4D59_RS01005	COG1413	lyase activity
G4D59_RS01010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4D59_RS01020	COG2311	Membrane
G4D59_RS01040	COG1476	TRANSCRIPTIONal
G4D59_RS01050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G4D59_RS01055	COG2207	Transcriptional regulator
G4D59_RS01070	COG1131	(ABC) transporter
G4D59_RS01085	COG1113	amino acid transport
G4D59_RS01090	COG0584	glycerophosphoryl diester phosphodiesterase
G4D59_RS01095	COG2271	Major facilitator Superfamily
G4D59_RS01110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4D59_RS01125	COG0640	Transcriptional regulator
G4D59_RS01140	COG1937	Protein conserved in bacteria
G4D59_RS01145	COG2210	Belongs to the sulfur carrier protein TusA family
G4D59_RS01155	COG0425	Belongs to the sulfur carrier protein TusA family
G4D59_RS01155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4D59_RS01160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4D59_RS01160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4D59_RS01165	COG0425	Belongs to the sulfur carrier protein TusA family
G4D59_RS01170	COG0730	response to heat
G4D59_RS01180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G4D59_RS01185	COG2814	Major facilitator Superfamily
G4D59_RS01200	COG1846	Transcriptional regulator
G4D59_RS01205	COG1683	Conserved Protein
G4D59_RS01215	COG0656	L-ascorbic acid biosynthetic process
G4D59_RS01220	COG0371	Dehydrogenase
G4D59_RS01225	COG1054	Belongs to the UPF0176 family
G4D59_RS01230	COG0531	amino acid
G4D59_RS01240	COG3711	transcriptional antiterminator
G4D59_RS01245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4D59_RS01245	COG1263	PTS System
G4D59_RS01245	COG2190	(PTS) system
G4D59_RS01250	COG2723	6-phospho-beta-galactosidase activity
G4D59_RS01265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4D59_RS01265	COG3711	transcriptional antiterminator
G4D59_RS01270	COG1940	carbohydrate kinase activity
G4D59_RS01275	COG0383	alpha-mannosidase activity
G4D59_RS01280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4D59_RS01285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4D59_RS01295	COG1404	Belongs to the peptidase S8 family
G4D59_RS01310	COG0833	amino acid
G4D59_RS01315	COG2040	homocysteine
G4D59_RS01320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4D59_RS01340	COG2814	Major facilitator Superfamily
G4D59_RS01345	COG0456	acetyltransferase
G4D59_RS01360	COG1404	Belongs to the peptidase S8 family
G4D59_RS01370	COG1309	transcriptional regulator
G4D59_RS01375	COG1917	Cupin 2, conserved barrel domain protein
G4D59_RS01380	COG1846	Transcriptional regulator
G4D59_RS01385	COG0318	PFAM AMP-dependent synthetase and ligase
G4D59_RS01390	COG0531	amino acid
G4D59_RS01400	COG0596	Alpha beta hydrolase
G4D59_RS01405	COG1115	amino acid carrier protein
G4D59_RS01410	COG2066	Belongs to the glutaminase family
G4D59_RS01415	COG4191	Histidine kinase
G4D59_RS01420	COG0784	Response regulator, receiver
G4D59_RS01425	COG1405	negative regulation of cell septum assembly
G4D59_RS01425	COG3012	SEC-C Motif Domain Protein
G4D59_RS01435	COG0667	Aldo Keto reductase
G4D59_RS01440	COG3290	protein histidine kinase activity
G4D59_RS01445	COG3279	Response regulator of the LytR AlgR family
G4D59_RS01450	COG4555	ABC transporter
G4D59_RS01455	COG1668	transmembrane transport
G4D59_RS01475	COG3773	Cell wall hydrolase
G4D59_RS01480	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS01490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4D59_RS01495	COG2310	stress, protein
G4D59_RS01500	COG2310	stress, protein
G4D59_RS01505	COG2310	stress, protein
G4D59_RS01510	COG0861	Integral membrane protein TerC family
G4D59_RS01540	COG3853	Toxic anion resistance protein (TelA)
G4D59_RS01545	COG0517	IMP dehydrogenase activity
G4D59_RS01545	COG4175	Glycine betaine
G4D59_RS01550	COG4176	ABC-type proline glycine betaine transport system permease component
G4D59_RS01555	COG2113	Glycine betaine
G4D59_RS01570	COG1473	amidohydrolase
G4D59_RS01575	COG1288	antiporter activity
G4D59_RS01580	COG0039	L-malate dehydrogenase activity
G4D59_RS01585	COG1620	l-lactate permease
G4D59_RS01590	COG1609	Transcriptional regulator
G4D59_RS01595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G4D59_RS01600	COG0561	phosphatase activity
G4D59_RS01605	COG0673	inositol 2-dehydrogenase activity
G4D59_RS01610	COG0738	Major facilitator superfamily
G4D59_RS01615	COG1280	lysine exporter protein (LysE YggA)
G4D59_RS01630	COG3403	YqcI/YcgG family
G4D59_RS01635	COG1113	amino acid transport
G4D59_RS01640	COG3665	Urea carboxylase-associated protein
G4D59_RS01645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G4D59_RS01655	COG1012	belongs to the aldehyde dehydrogenase family
G4D59_RS01660	COG0710	3-dehydroquinate dehydratase activity
G4D59_RS01665	COG0028	Belongs to the TPP enzyme family
G4D59_RS01675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4D59_RS01680	COG2271	Major facilitator Superfamily
G4D59_RS01695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G4D59_RS01700	COG2226	methyltransferase
G4D59_RS01705	COG0583	DNA-binding transcription factor activity
G4D59_RS01710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4D59_RS01715	COG3458	cephalosporin-C deacetylase activity
G4D59_RS01725	COG3541	Predicted nucleotidyltransferase
G4D59_RS01730	COG0506	proline dehydrogenase activity
G4D59_RS01735	COG1012	belongs to the aldehyde dehydrogenase family
G4D59_RS01740	COG2508	Transcriptional regulator
G4D59_RS01745	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G4D59_RS01750	COG0765	amino acid transport
G4D59_RS01755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4D59_RS01765	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G4D59_RS01770	COG1522	sequence-specific DNA binding
G4D59_RS01775	COG2746	aminoglycoside 3-N-acetyltransferase activity
G4D59_RS01785	COG0840	transmembrane signaling receptor activity
G4D59_RS01785	COG3290	protein histidine kinase activity
G4D59_RS01790	COG3209	COG3209 Rhs family protein
G4D59_RS01810	COG3842	ATPase activity
G4D59_RS01815	COG1176	ABC-type spermidine putrescine transport system, permease component I
G4D59_RS01830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4D59_RS01835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4D59_RS01850	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
G4D59_RS01855	COG0697	spore germination
G4D59_RS01860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4D59_RS01870	COG2207	Transcriptional regulator
G4D59_RS01870	COG3708	Transcriptional regulator
G4D59_RS01880	COG2364	Membrane
G4D59_RS01885	COG1126	abc transporter atp-binding protein
G4D59_RS01890	COG0765	amino acid transport
G4D59_RS01895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4D59_RS01900	COG0412	Dienelactone hydrolase
G4D59_RS01905	COG0833	amino acid
G4D59_RS01910	COG3104	oligopeptide transport
G4D59_RS01915	COG5434	Belongs to the glycosyl hydrolase 28 family
G4D59_RS01920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4D59_RS01925	COG0456	acetyltransferase
G4D59_RS01930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4D59_RS01935	COG0765	amino acid transport
G4D59_RS01940	COG1126	abc transporter atp-binding protein
G4D59_RS01945	COG1473	amidohydrolase
G4D59_RS01950	COG2079	MmgE PrpD family protein
G4D59_RS01960	COG0745	RESPONSE REGULATOR receiver
G4D59_RS01965	COG3850	Histidine kinase
G4D59_RS01965	COG5002	protein histidine kinase activity
G4D59_RS01970	COG1366	Belongs to the anti-sigma-factor antagonist family
G4D59_RS01975	COG0527	aspartate kinase activity
G4D59_RS01980	COG2814	Major facilitator Superfamily
G4D59_RS01985	COG1309	transcriptional regulator
G4D59_RS01995	COG0640	Transcriptional regulator
G4D59_RS02005	COG0583	DNA-binding transcription factor activity
G4D59_RS02010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4D59_RS02015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G4D59_RS02020	COG0531	amino acid
G4D59_RS02025	COG1012	belongs to the aldehyde dehydrogenase family
G4D59_RS02030	COG2249	NAD(P)H dehydrogenase (quinone) activity
G4D59_RS02035	COG4549	nuclear export factor GLE1
G4D59_RS02040	COG1276	copper resistance
G4D59_RS02040	COG2372	response to copper ion
G4D59_RS02045	COG2213	PTS system mannitol-specific
G4D59_RS02050	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4D59_RS02055	COG0246	Mannitol dehydrogenase
G4D59_RS02060	COG0840	transmembrane signaling receptor activity
G4D59_RS02095	COG0346	lactoylglutathione lyase activity
G4D59_RS02105	COG0561	phosphatase activity
G4D59_RS02110	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G4D59_RS02115	COG1914	H( )-stimulated, divalent metal cation uptake system
G4D59_RS02120	COG4336	lyase activity
G4D59_RS02125	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G4D59_RS02130	COG1984	allophanate hydrolase subunit 2
G4D59_RS02135	COG1414	Transcriptional regulator
G4D59_RS02140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G4D59_RS02145	COG2755	lipolytic protein G-D-S-L family
G4D59_RS02155	COG3711	transcriptional antiterminator
G4D59_RS02160	COG2226	methyltransferase
G4D59_RS02165	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS02170	COG3871	stress protein (general stress protein 26)
G4D59_RS02190	COG2814	Major facilitator Superfamily
G4D59_RS02195	COG1802	Transcriptional regulator
G4D59_RS02200	COG2207	Transcriptional regulator
G4D59_RS02200	COG1917	Cupin 2, conserved barrel domain protein
G4D59_RS02205	COG0697	spore germination
G4D59_RS02210	COG0473	3-isopropylmalate dehydrogenase activity
G4D59_RS02215	COG0551	DNA topoisomerase type I activity
G4D59_RS02215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4D59_RS02220	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
G4D59_RS02225	COG3706	GGDEF domain
G4D59_RS02230	COG5298	Protein conserved in bacteria
G4D59_RS02235	COG1215	transferase activity, transferring glycosyl groups
G4D59_RS02245	COG0531	amino acid
G4D59_RS02250	COG0028	Belongs to the TPP enzyme family
G4D59_RS02255	COG5444	nuclease activity
G4D59_RS02285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4D59_RS02290	COG1914	H( )-stimulated, divalent metal cation uptake system
G4D59_RS02295	COG2261	transglycosylase associated protein
G4D59_RS02300	COG2217	Heavy metal translocating P-type atpase
G4D59_RS02305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G4D59_RS02310	COG3290	protein histidine kinase activity
G4D59_RS02315	COG4565	transcriptional regulatory protein
G4D59_RS02320	COG1301	dicarboxylic acid transport
G4D59_RS02325	COG0628	permease
G4D59_RS02330	COG1301	dicarboxylic acid transport
G4D59_RS02335	COG1131	(ABC) transporter
G4D59_RS02340	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
G4D59_RS02355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4D59_RS02360	COG1181	Belongs to the D-alanine--D-alanine ligase family
G4D59_RS02365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G4D59_RS02380	COG0513	Belongs to the DEAD box helicase family
G4D59_RS02385	COG3402	PFAM membrane-flanked domain
G4D59_RS02390	COG3428	Bacterial PH domain
G4D59_RS02395	COG0705	Rhomboid family
G4D59_RS02400	COG0736	holo-[acyl-carrier-protein] synthase activity
G4D59_RS02405	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G4D59_RS02410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G4D59_RS02415	COG0864	Transcriptional regulator
G4D59_RS02420	COG2337	Toxic component of a toxin-antitoxin (TA) module
G4D59_RS02425	COG1366	Belongs to the anti-sigma-factor antagonist family
G4D59_RS02430	COG1366	Belongs to the anti-sigma-factor antagonist family
G4D59_RS02435	COG2172	sigma factor antagonist activity
G4D59_RS02440	COG2208	phosphoserine phosphatase activity
G4D59_RS02445	COG1366	Belongs to the anti-sigma-factor antagonist family
G4D59_RS02450	COG2172	sigma factor antagonist activity
G4D59_RS02455	COG1191	sigma factor activity
G4D59_RS02460	COG2208	phosphoserine phosphatase activity
G4D59_RS02465	COG2183	response to ionizing radiation
G4D59_RS02475	COG3091	SprT-like family
G4D59_RS02480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G4D59_RS02485	COG0022	dehydrogenase e1 component
G4D59_RS02490	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4D59_RS02495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4D59_RS02500	COG3284	Transcriptional regulator
G4D59_RS02545	COG1278	Cold shock
G4D59_RS02550	COG1263	PTS System
G4D59_RS02550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4D59_RS02550	COG2190	(PTS) system
G4D59_RS02555	COG3394	polysaccharide catabolic process
G4D59_RS02560	COG3711	transcriptional antiterminator
G4D59_RS02565	COG1064	alcohol dehydrogenase
G4D59_RS02570	COG0789	Transcriptional regulator
G4D59_RS02590	COG0477	Major facilitator Superfamily
G4D59_RS02595	COG0657	acetylesterase activity
G4D59_RS02605	COG4221	oxidoreductase activity
G4D59_RS02615	COG0252	asparaginase activity
G4D59_RS02620	COG2267	carboxylic ester hydrolase activity
G4D59_RS02635	COG2814	Major facilitator Superfamily
G4D59_RS02640	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
G4D59_RS02645	COG2409	Drug exporters of the RND superfamily
G4D59_RS02650	COG4585	Histidine kinase
G4D59_RS02655	COG2197	response regulator
G4D59_RS02700	COG1309	transcriptional regulator
G4D59_RS02705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G4D59_RS02710	COG1846	Transcriptional regulator
G4D59_RS02715	COG0778	Nitroreductase
G4D59_RS02730	COG1396	sequence-specific DNA binding
G4D59_RS02740	COG0456	acetyltransferase
G4D59_RS02755	COG4122	O-methyltransferase activity
G4D59_RS02765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
G4D59_RS02770	COG0697	spore germination
G4D59_RS02780	COG1301	dicarboxylic acid transport
G4D59_RS02820	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G4D59_RS02825	COG0802	atpase or kinase
G4D59_RS02830	COG1214	PFAM Peptidase M22, glycoprotease
G4D59_RS02835	COG0456	acetyltransferase
G4D59_RS02840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G4D59_RS02845	COG0488	(ABC) transporter
G4D59_RS02850	COG0315	cyclic pyranopterin monophosphate synthase activity
G4D59_RS02855	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
G4D59_RS02860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4D59_RS02865	COG0805	protein transport
G4D59_RS02880	COG1266	CAAX protease self-immunity
G4D59_RS02885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G4D59_RS02890	COG0459	protein refolding
G4D59_RS02895	COG1846	Transcriptional regulator
G4D59_RS02900	COG0456	acetyltransferase
G4D59_RS02905	COG2808	Putative FMN-binding domain
G4D59_RS02910	COG1876	peptidase activity
G4D59_RS02935	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G4D59_RS02940	COG0823	Involved in the tonB-independent uptake of proteins
G4D59_RS02950	COG2132	Multicopper oxidase
G4D59_RS02955	COG1113	amino acid transport
G4D59_RS02960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G4D59_RS02965	COG0714	Associated with various cellular activities
G4D59_RS02970	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
G4D59_RS02975	COG1305	Transglutaminase-like
G4D59_RS02980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G4D59_RS02980	COG0519	Catalyzes the synthesis of GMP from XMP
G4D59_RS03005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G4D59_RS03015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4D59_RS03045	COG3279	Response regulator of the LytR AlgR family
G4D59_RS03065	COG1595	DNA-templated transcription, initiation
G4D59_RS03075	COG2814	Major facilitator Superfamily
G4D59_RS03080	COG0583	DNA-binding transcription factor activity
G4D59_RS03085	COG2252	PERMEase
G4D59_RS03095	COG5583	Uncharacterized small protein (DUF2292)
G4D59_RS03100	COG3064	Membrane
G4D59_RS03105	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
G4D59_RS03115	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G4D59_RS03120	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G4D59_RS03125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G4D59_RS03130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G4D59_RS03135	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G4D59_RS03140	COG0047	phosphoribosylformylglycinamidine synthase activity
G4D59_RS03145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G4D59_RS03150	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
G4D59_RS03155	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G4D59_RS03160	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G4D59_RS03165	COG0138	bifunctional purine biosynthesis protein purh
G4D59_RS03170	COG0151	Belongs to the GarS family
G4D59_RS03190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G4D59_RS03195	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G4D59_RS03200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G4D59_RS03205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4D59_RS03215	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G4D59_RS03220	COG4496	protein, YerC YecD
G4D59_RS03230	COG0069	glutamate synthase activity
G4D59_RS03245	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
G4D59_RS03250	COG0210	DNA helicase
G4D59_RS03255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G4D59_RS03260	COG4851	CamS sex pheromone cAM373 precursor
G4D59_RS03265	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G4D59_RS03270	COG1285	pathogenesis
G4D59_RS03275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4D59_RS03280	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G4D59_RS03285	COG0154	amidase activity
G4D59_RS03290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G4D59_RS03295	COG1309	transcriptional regulator
G4D59_RS03300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4D59_RS03305	COG1957	nucleoside hydrolase
G4D59_RS03310	COG1597	lipid kinase activity
G4D59_RS03315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4D59_RS03340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4D59_RS03355	COG1959	2 iron, 2 sulfur cluster binding
G4D59_RS03360	COG0492	ferredoxin-NADP+ reductase activity
G4D59_RS03375	COG1486	melibiose metabolic process
G4D59_RS03385	COG2211	Major facilitator Superfamily
G4D59_RS03415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G4D59_RS03420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4D59_RS03425	COG1442	glycosyl transferase family 8
G4D59_RS03430	COG1216	Glycosyl transferase, family 2
G4D59_RS03435	COG1442	glycosyl transferase family 8
G4D59_RS03440	COG2223	nitrite transmembrane transporter activity
G4D59_RS03450	COG0471	metal ion transport
G4D59_RS03465	COG0071	Belongs to the small heat shock protein (HSP20) family
G4D59_RS03480	COG0531	amino acid
G4D59_RS03485	COG0457	Tetratricopeptide repeat
G4D59_RS03485	COG0463	Glycosyl transferase, family 2
G4D59_RS03490	COG0488	(ABC) transporter
G4D59_RS03495	COG1469	GTP cyclohydrolase I activity
G4D59_RS03500	COG0789	Transcriptional regulator
G4D59_RS03505	COG2814	Major facilitator Superfamily
G4D59_RS03510	COG0488	(ABC) transporter
G4D59_RS03515	COG0513	Belongs to the DEAD box helicase family
G4D59_RS03520	COG2130	NADP-dependent
G4D59_RS03540	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4D59_RS03540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4D59_RS03545	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G4D59_RS03555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4D59_RS03555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4D59_RS03565	COG3290	protein histidine kinase activity
G4D59_RS03570	COG4565	transcriptional regulatory protein
G4D59_RS03575	COG3181	Tripartite tricarboxylate transporter family receptor
G4D59_RS03580	COG2851	Citrate transporter
G4D59_RS03590	COG3479	Phenolic acid decarboxylase
G4D59_RS03595	COG1695	Transcriptional regulator
G4D59_RS03600	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
G4D59_RS03610	COG1254	Belongs to the acylphosphatase family
G4D59_RS03615	COG2258	MOSC domain
G4D59_RS03630	COG0024	Methionine aminopeptidase
G4D59_RS03635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4D59_RS03635	COG1263	PTS System
G4D59_RS03640	COG3739	integral membrane protein
G4D59_RS03655	COG1368	sulfuric ester hydrolase activity
G4D59_RS03660	COG0076	glutamate decarboxylase activity
G4D59_RS03675	COG1263	PTS System
G4D59_RS03675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4D59_RS03680	COG0366	Alpha amylase catalytic
G4D59_RS03685	COG2188	Transcriptional regulator
G4D59_RS03695	COG0737	Belongs to the 5'-nucleotidase family
G4D59_RS03700	COG0693	protein deglycase activity
G4D59_RS03705	COG4840	Belongs to the UPF0435 family
G4D59_RS03710	COG1115	amino acid carrier protein
G4D59_RS03715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4D59_RS03720	COG4980	gas vesicle protein
G4D59_RS03725	COG1295	ribonuclease BN
G4D59_RS03730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4D59_RS03735	COG0477	Major facilitator Superfamily
G4D59_RS03745	COG0387	Pfam Sodium calcium exchanger
G4D59_RS03755	COG0217	transcriptional regulatory protein
G4D59_RS03765	COG0668	transmembrane transport
G4D59_RS03770	COG0535	radical SAM domain protein
G4D59_RS03780	COG0726	polysaccharide deacetylase
G4D59_RS03790	COG0598	Magnesium transport protein CorA
G4D59_RS03800	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
G4D59_RS03805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4D59_RS03825	COG0789	Transcriptional regulator
G4D59_RS03830	COG2814	Major facilitator Superfamily
G4D59_RS03880	COG2076	Multidrug Resistance protein
G4D59_RS03885	COG2076	Multidrug Resistance protein
G4D59_RS03890	COG1309	transcriptional regulator
G4D59_RS03900	COG4637	Psort location Cytoplasmic, score
G4D59_RS03905	COG2755	lipolytic protein G-D-S-L family
G4D59_RS03910	COG0492	ferredoxin-NADP+ reductase activity
G4D59_RS03915	COG2169	Transcriptional regulator
G4D59_RS03920	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
G4D59_RS03925	COG1132	(ABC) transporter
G4D59_RS03930	COG1742	UPF0060 membrane protein
G4D59_RS03935	COG1595	DNA-templated transcription, initiation
G4D59_RS03955	COG2318	DinB family
G4D59_RS03965	COG1846	Transcriptional regulator
G4D59_RS03970	COG0392	lysyltransferase activity
G4D59_RS03970	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
G4D59_RS03990	COG0778	Nitroreductase
G4D59_RS04005	COG1090	epimerase
G4D59_RS04010	COG2137	regulation of response to DNA damage stimulus
G4D59_RS04035	COG0463	Glycosyl transferase, family 2
G4D59_RS04040	COG4485	Bacterial membrane protein, YfhO
G4D59_RS04045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4D59_RS04060	COG2140	Oxalate decarboxylase
G4D59_RS04070	COG1191	sigma factor activity
G4D59_RS04080	COG1988	membrane-bound metal-dependent
G4D59_RS04085	COG1194	a g-specific adenine glycosylase
G4D59_RS04095	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS04110	COG3557	Belongs to the UPF0374 family
G4D59_RS04115	COG1132	(ABC) transporter
G4D59_RS04120	COG0444	Belongs to the ABC transporter superfamily
G4D59_RS04125	COG4608	Belongs to the ABC transporter superfamily
G4D59_RS04130	COG0747	negative chemotaxis
G4D59_RS04135	COG0601	transmembrane transport
G4D59_RS04140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4D59_RS04145	COG4129	membrane
G4D59_RS04150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G4D59_RS04155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G4D59_RS04160	COG0735	belongs to the Fur family
G4D59_RS04305	COG1368	sulfuric ester hydrolase activity
G4D59_RS04310	COG0681	Belongs to the peptidase S26 family
G4D59_RS04315	COG2873	o-acetylhomoserine
G4D59_RS04325	COG1116	anion transmembrane transporter activity
G4D59_RS04330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G4D59_RS04335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4D59_RS04350	COG1131	(ABC) transporter
G4D59_RS04380	COG3382	B3 4 domain protein
G4D59_RS04385	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G4D59_RS04395	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G4D59_RS04400	COG2766	serine protein kinase
G4D59_RS04405	COG2718	Belongs to the UPF0229 family
G4D59_RS04410	COG1566	PFAM secretion protein HlyD family protein
G4D59_RS04415	COG2814	Major facilitator Superfamily
G4D59_RS04420	COG0655	NAD(P)H dehydrogenase (quinone) activity
G4D59_RS04430	COG1278	Cold shock
G4D59_RS04435	COG3706	GGDEF domain
G4D59_RS04460	COG5577	PFAM Coat F domain
G4D59_RS04465	COG5002	protein histidine kinase activity
G4D59_RS04470	COG1525	nuclease
G4D59_RS04470	COG4085	toxin activity
G4D59_RS04470	COG0737	Belongs to the 5'-nucleotidase family
G4D59_RS04475	COG3764	Sortase (surface protein transpeptidase)
G4D59_RS04480	COG0564	pseudouridine synthase activity
G4D59_RS04490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4D59_RS04495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4D59_RS04495	COG3153	acetyltransferase
G4D59_RS04515	COG3835	regulator
G4D59_RS04520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G4D59_RS04525	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
G4D59_RS04530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G4D59_RS04535	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G4D59_RS04540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G4D59_RS04545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4D59_RS04550	COG4585	Histidine kinase
G4D59_RS04550	COG2203	Gaf domain
G4D59_RS04555	COG2197	response regulator
G4D59_RS04570	COG0753	catalase activity
G4D59_RS04575	COG1959	2 iron, 2 sulfur cluster binding
G4D59_RS04580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G4D59_RS04580	COG1017	nitric oxide dioxygenase activity
G4D59_RS04585	COG2719	SpoVR family
G4D59_RS04590	COG1785	Belongs to the alkaline phosphatase family
G4D59_RS04595	COG1388	LysM domain
G4D59_RS04595	COG0791	NLP P60 protein
G4D59_RS04600	COG0531	amino acid
G4D59_RS04615	COG1595	DNA-templated transcription, initiation
G4D59_RS04620	COG0204	Acyl-transferase
G4D59_RS04625	COG1253	flavin adenine dinucleotide binding
G4D59_RS04630	COG0789	Transcriptional regulator
G4D59_RS04635	COG1253	flavin adenine dinucleotide binding
G4D59_RS04650	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G4D59_RS04655	COG0584	glycerophosphoryl diester phosphodiesterase
G4D59_RS04665	COG0668	transmembrane transport
G4D59_RS04670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G4D59_RS04675	COG0726	polysaccharide deacetylase
G4D59_RS04680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4D59_RS04685	COG0589	response to stress
G4D59_RS04690	COG1132	(ABC) transporter
G4D59_RS04695	COG1132	(ABC) transporter
G4D59_RS04700	COG0702	epimerase
G4D59_RS04710	COG3842	ATPase activity
G4D59_RS04715	COG2508	Transcriptional regulator
G4D59_RS04725	COG0189	ligase activity
G4D59_RS04730	COG0189	ligase activity
G4D59_RS04735	COG4399	Belongs to the UPF0754 family
G4D59_RS04740	COG3679	Belongs to the UPF0342 family
G4D59_RS04745	COG0561	phosphatase activity
G4D59_RS04750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4D59_RS04760	COG0475	glutathione-regulated potassium exporter activity
G4D59_RS04765	COG0490	domain, Protein
G4D59_RS04775	COG1024	Enoyl-CoA hydratase
G4D59_RS04785	COG0420	3'-5' exonuclease activity
G4D59_RS04790	COG4717	serine-type aminopeptidase activity
G4D59_RS04795	COG3481	metal-dependent phosphohydrolase, HD sub domain
G4D59_RS04805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4D59_RS04830	COG1846	Transcriptional regulator
G4D59_RS04835	COG4980	gas vesicle protein
G4D59_RS04850	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G4D59_RS04855	COG0537	adenosine 5'-monophosphoramidase activity
G4D59_RS04860	COG1131	(ABC) transporter
G4D59_RS04865	COG4473	ABC transporter
G4D59_RS04875	COG1473	amidohydrolase
G4D59_RS04885	COG2329	Antibiotic biosynthesis monooxygenase
G4D59_RS04890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4D59_RS04895	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G4D59_RS04900	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G4D59_RS04905	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
G4D59_RS04910	COG1309	transcriptional regulator
G4D59_RS04915	COG1511	domain protein
G4D59_RS04920	COG1363	Peptidase, m42
G4D59_RS04925	COG1301	dicarboxylic acid transport
G4D59_RS04935	COG1234	tRNA 3'-trailer cleavage
G4D59_RS04940	COG0095	Lipoate-protein ligase
G4D59_RS04945	COG0318	PFAM AMP-dependent synthetase and ligase
G4D59_RS04955	COG0501	Belongs to the peptidase M48B family
G4D59_RS04960	COG1404	Belongs to the peptidase S8 family
G4D59_RS04965	COG0406	alpha-ribazole phosphatase activity
G4D59_RS04970	COG0840	transmembrane signaling receptor activity
G4D59_RS04975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4D59_RS04975	COG0723	plastoquinol--plastocyanin reductase activity
G4D59_RS04980	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS04990	COG4903	ComK protein
G4D59_RS05005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4D59_RS05010	COG2814	Major facilitator Superfamily
G4D59_RS05015	COG2732	(Barnase) inhibitor
G4D59_RS05020	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4D59_RS05025	COG4605	iron ion homeostasis
G4D59_RS05030	COG4604	ABC transporter, ATP-binding protein
G4D59_RS05035	COG4607	ABC-type enterochelin transport system periplasmic component
G4D59_RS05040	COG1316	TRANSCRIPTIONal
G4D59_RS05055	COG0398	Pfam SNARE associated Golgi protein
G4D59_RS05060	COG0681	Belongs to the peptidase S26 family
G4D59_RS05070	COG3180	Ammonia monooxygenase
G4D59_RS05085	COG2259	Doxx family
G4D59_RS05090	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
G4D59_RS05095	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
G4D59_RS05100	COG1074	ATP-dependent DNA helicase activity
G4D59_RS05105	COG0420	3'-5' exonuclease activity
G4D59_RS05110	COG0419	ATPase involved in DNA repair
G4D59_RS05115	COG1403	HNH endonuclease
G4D59_RS05155	COG5337	Spore coat protein CotH
G4D59_RS05165	COG0179	Fumarylacetoacetate (FAA) hydrolase
G4D59_RS05180	COG0367	asparagine synthase
G4D59_RS05195	COG1562	ergosterol biosynthetic process
G4D59_RS05200	COG0534	Mate efflux family protein
G4D59_RS05205	COG2207	Transcriptional regulator
G4D59_RS05205	COG1917	Cupin 2, conserved barrel domain protein
G4D59_RS05230	COG0076	glutamate decarboxylase activity
G4D59_RS05265	COG0646	methionine synthase
G4D59_RS05265	COG1410	methionine synthase
G4D59_RS05270	COG0646	methionine synthase
G4D59_RS05270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G4D59_RS05275	COG1666	GTP binding
G4D59_RS05280	COG2996	Protein conserved in bacteria
G4D59_RS05285	COG1744	ABC transporter substrate-binding protein PnrA-like
G4D59_RS05290	COG0840	transmembrane signaling receptor activity
G4D59_RS05295	COG1307	EDD domain protein, DegV family
G4D59_RS05300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4D59_RS05320	COG0561	phosphatase activity
G4D59_RS05325	COG1073	alpha beta
G4D59_RS05330	COG2151	metal-sulfur cluster biosynthetic enzyme
G4D59_RS05335	COG0277	FAD linked oxidase domain protein
G4D59_RS05340	COG2271	Major facilitator Superfamily
G4D59_RS05345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G4D59_RS05350	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G4D59_RS05355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G4D59_RS05360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4D59_RS05365	COG0505	Belongs to the CarA family
G4D59_RS05370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G4D59_RS05375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4D59_RS05385	COG2814	Major facilitator Superfamily
G4D59_RS05395	COG2267	carboxylic ester hydrolase activity
G4D59_RS05405	COG1744	ABC transporter substrate-binding protein PnrA-like
G4D59_RS05420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4D59_RS05425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4D59_RS05430	COG5504	Zn-dependent protease
G4D59_RS05435	COG0444	Belongs to the ABC transporter superfamily
G4D59_RS05440	COG4608	Belongs to the ABC transporter superfamily
G4D59_RS05450	COG0601	transmembrane transport
G4D59_RS05455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4D59_RS05465	COG0180	Tryptophanyl-tRNA synthetase
G4D59_RS05470	COG4166	transmembrane transport
G4D59_RS05475	COG0601	transmembrane transport
G4D59_RS05480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4D59_RS05485	COG0444	Belongs to the ABC transporter superfamily
G4D59_RS05490	COG4608	Belongs to the ABC transporter superfamily
G4D59_RS05500	COG0456	acetyltransferase
G4D59_RS05505	COG1393	Belongs to the ArsC family
G4D59_RS05510	COG0861	Integral membrane protein TerC family
G4D59_RS05515	COG4862	establishment of competence for transformation
G4D59_RS05520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4D59_RS05530	COG1164	Oligoendopeptidase f
G4D59_RS05540	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G4D59_RS05545	COG2346	COG2346, Truncated hemoglobins
G4D59_RS05550	COG0741	lytic transglycosylase activity
G4D59_RS05555	COG4116	CYTH
G4D59_RS05565	COG2357	RelA SpoT domain protein
G4D59_RS05570	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G4D59_RS05575	COG0564	pseudouridine synthase activity
G4D59_RS05580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G4D59_RS05585	COG0475	glutathione-regulated potassium exporter activity
G4D59_RS05585	COG0569	domain protein
G4D59_RS05590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G4D59_RS05595	COG0352	thiamine-phosphate diphosphorylase activity
G4D59_RS05605	COG2104	thiamine diphosphate biosynthetic process
G4D59_RS05610	COG2022	thiamine diphosphate biosynthetic process
G4D59_RS05615	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G4D59_RS05620	COG0351	phosphomethylpyrimidine kinase
G4D59_RS05625	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G4D59_RS05680	COG0210	DNA helicase
G4D59_RS05690	COG2153	protein acetylation
G4D59_RS05695	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
G4D59_RS05700	COG2382	esterase
G4D59_RS05705	COG0626	cystathionine gamma-synthase activity
G4D59_RS05710	COG0626	cystathionine gamma-synthase activity
G4D59_RS05735	COG0825	malonyl-CoA metabolic process
G4D59_RS05750	COG0457	Tetratricopeptide repeat
G4D59_RS05760	COG1280	lysine exporter protein (LysE YggA)
G4D59_RS05770	COG2364	Membrane
G4D59_RS05805	COG3173	Aminoglycoside phosphotransferase
G4D59_RS05810	COG0583	DNA-binding transcription factor activity
G4D59_RS05830	COG0583	DNA-binding transcription factor activity
G4D59_RS05835	COG2807	transmembrane transport
G4D59_RS05865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G4D59_RS05875	COG1309	transcriptional regulator
G4D59_RS05885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G4D59_RS05890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G4D59_RS05895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G4D59_RS05900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G4D59_RS05920	COG4195	phage-related replication protein
G4D59_RS05925	COG2856	Zn peptidase
G4D59_RS05930	COG3409	Peptidoglycan-binding domain 1 protein
G4D59_RS05930	COG5632	N-Acetylmuramoyl-L-alanine amidase
G4D59_RS05945	COG0306	phosphate transporter
G4D59_RS05950	COG1392	Phosphate transport regulator
G4D59_RS05960	COG0405	Gamma-glutamyltransferase
G4D59_RS05965	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G4D59_RS05975	COG4208	sulfate ABC transporter
G4D59_RS05990	COG3775	system Galactitol-specific IIC component
G4D59_RS06005	COG1063	alcohol dehydrogenase
G4D59_RS06010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G4D59_RS06015	COG0022	dehydrogenase e1 component
G4D59_RS06015	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4D59_RS06020	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4D59_RS06025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4D59_RS06030	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS06035	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS06040	COG2390	Transcriptional regulator
G4D59_RS06050	COG0531	amino acid
G4D59_RS06055	COG0346	lactoylglutathione lyase activity
G4D59_RS06060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4D59_RS06065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G4D59_RS06070	COG2362	D-Aminopeptidase
G4D59_RS06075	COG0601	transmembrane transport
G4D59_RS06080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4D59_RS06085	COG0444	Belongs to the ABC transporter superfamily
G4D59_RS06090	COG4166	transmembrane transport
G4D59_RS06095	COG1619	proteins homologs of microcin C7 resistance protein MccF
G4D59_RS06100	COG4948	Mandelate Racemase Muconate Lactonizing
G4D59_RS06105	COG0791	NLP P60 protein
G4D59_RS06110	COG4608	Belongs to the ABC transporter superfamily
G4D59_RS06115	COG1834	amidinotransferase
G4D59_RS06120	COG1607	acyl-coa hydrolase
G4D59_RS06125	COG1695	Transcriptional regulator
G4D59_RS06140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4D59_RS06150	COG2076	Multidrug Resistance protein
G4D59_RS06155	COG2076	Multidrug Resistance protein
G4D59_RS06165	COG0788	formyltetrahydrofolate deformylase activity
G4D59_RS06170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G4D59_RS06175	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G4D59_RS06180	COG0457	Tetratricopeptide repeat
G4D59_RS06190	COG1764	response to oxidative stress
G4D59_RS06195	COG1846	Transcriptional regulator
G4D59_RS06200	COG1764	response to oxidative stress
G4D59_RS06205	COG0590	tRNA wobble adenosine to inosine editing
G4D59_RS06210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G4D59_RS06215	COG1404	Belongs to the peptidase S8 family
G4D59_RS06230	COG0745	RESPONSE REGULATOR receiver
G4D59_RS06235	COG3850	Histidine kinase
G4D59_RS06235	COG5002	protein histidine kinase activity
G4D59_RS06240	COG3212	peptidase
G4D59_RS06245	COG3212	peptidase
G4D59_RS06255	COG2239	Acts as a magnesium transporter
G4D59_RS06265	COG0583	DNA-binding transcription factor activity
G4D59_RS06275	COG0789	Transcriptional regulator
G4D59_RS06290	COG1846	Transcriptional regulator
G4D59_RS06295	COG3300	MHYT domain
G4D59_RS06295	COG5001	Diguanylate cyclase
G4D59_RS06300	COG0586	Pfam SNARE associated Golgi protein
G4D59_RS06305	COG0861	Integral membrane protein TerC family
G4D59_RS06310	COG1191	sigma factor activity
G4D59_RS06330	COG0501	Belongs to the peptidase M48B family
G4D59_RS06335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G4D59_RS06340	COG2323	membrane
G4D59_RS06355	COG3594	Acyltransferase
G4D59_RS06360	COG5002	protein histidine kinase activity
G4D59_RS06365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G4D59_RS06370	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
G4D59_RS06375	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
G4D59_RS06380	COG0436	Aminotransferase
G4D59_RS06385	COG1850	ribulose-bisphosphate carboxylase activity
G4D59_RS06390	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
G4D59_RS06395	COG0235	Class ii aldolase
G4D59_RS06400	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
G4D59_RS06410	COG3852	Histidine kinase
G4D59_RS06415	COG1846	Transcriptional regulator
G4D59_RS06420	COG1360	Flagellar Motor Protein
G4D59_RS06425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G4D59_RS06435	COG0542	response to heat
G4D59_RS06440	COG3949	Membrane
G4D59_RS06445	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G4D59_RS06450	COG0720	synthase
G4D59_RS06455	COG0602	queuosine metabolic process
G4D59_RS06460	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G4D59_RS06470	COG4873	Protein conserved in bacteria
G4D59_RS06480	COG3773	Cell wall hydrolase
G4D59_RS06485	COG2244	polysaccharide biosynthetic process
G4D59_RS06490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4D59_RS06495	COG2217	Heavy metal translocating P-type atpase
G4D59_RS06500	COG0006	proline dipeptidase activity
G4D59_RS06505	COG1609	Transcriptional regulator
G4D59_RS06510	COG3711	transcriptional antiterminator
G4D59_RS06515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4D59_RS06515	COG2190	(PTS) system
G4D59_RS06515	COG1263	PTS System
G4D59_RS06520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4D59_RS06525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4D59_RS06535	COG1533	DNA photolyase activity
G4D59_RS06540	COG0840	transmembrane signaling receptor activity
G4D59_RS06550	COG2084	Dehydrogenase
G4D59_RS06555	COG2340	Cysteine-rich secretory protein family
G4D59_RS06560	COG0768	penicillin binding
G4D59_RS06565	COG4191	Histidine kinase
G4D59_RS06570	COG0436	Aminotransferase
G4D59_RS06575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G4D59_RS06585	COG1714	RDD family
G4D59_RS06595	COG0784	Response regulator, receiver
G4D59_RS06595	COG0835	chemotaxis
G4D59_RS06605	COG2207	Transcriptional regulator
G4D59_RS06605	COG1917	Cupin 2, conserved barrel domain protein
G4D59_RS06610	COG0697	spore germination
G4D59_RS06625	COG2814	Major facilitator Superfamily
G4D59_RS06630	COG1376	ErfK ybiS ycfS ynhG family protein
G4D59_RS06635	COG1408	metallophosphoesterase
G4D59_RS06640	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS06645	COG2200	EAL domain
G4D59_RS06650	COG3546	catalase activity
G4D59_RS06655	COG4703	Protein of unknown function (DUF1797)
G4D59_RS06660	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
G4D59_RS06670	COG0517	IMP dehydrogenase activity
G4D59_RS06675	COG0583	DNA-binding transcription factor activity
G4D59_RS06685	COG0716	FMN binding
G4D59_RS06695	COG0716	FMN binding
G4D59_RS06700	COG2171	N-acyltransferase activity
G4D59_RS06705	COG1473	amidohydrolase
G4D59_RS06715	COG0668	transmembrane transport
G4D59_RS06720	COG0450	alkyl hydroperoxide reductase
G4D59_RS06725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4D59_RS06740	COG0746	molybdenum cofactor guanylyltransferase activity
G4D59_RS06745	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G4D59_RS06750	COG0303	'Molybdopterin
G4D59_RS06755	COG1763	Mo-molybdopterin cofactor biosynthetic process
G4D59_RS06760	COG0314	molybdopterin synthase activity
G4D59_RS06765	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
G4D59_RS06780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4D59_RS06785	COG1136	(ABC) transporter
G4D59_RS06790	COG0577	efflux transmembrane transporter activity
G4D59_RS06795	COG1349	DNA-binding transcription factor activity
G4D59_RS06800	COG1105	Belongs to the carbohydrate kinase PfkB family
G4D59_RS06805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4D59_RS06805	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4D59_RS06805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4D59_RS06810	COG0681	Belongs to the peptidase S26 family
G4D59_RS06820	COG0488	(ABC) transporter
G4D59_RS06830	COG2309	aminopeptidase activity
G4D59_RS06840	COG1077	Cell shape determining protein MreB Mrl
G4D59_RS06845	COG2002	toxin-antitoxin pair type II binding
G4D59_RS06850	COG3852	Histidine kinase
G4D59_RS06855	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
G4D59_RS06855	COG2105	PFAM AIG2 family protein
G4D59_RS06860	COG0569	domain protein
G4D59_RS06865	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G4D59_RS06870	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
G4D59_RS06875	COG5503	Protein of unknown function (DUF1447)
G4D59_RS06880	COG0561	phosphatase activity
G4D59_RS06885	COG0242	peptide deformylase activity
G4D59_RS06900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G4D59_RS06905	COG0022	dehydrogenase e1 component
G4D59_RS06910	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4D59_RS06915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4D59_RS06920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4D59_RS06930	COG1982	Orn Lys Arg decarboxylase major
G4D59_RS06935	COG4476	Belongs to the UPF0223 family
G4D59_RS06940	COG4493	Belongs to the UPF0637 family
G4D59_RS06950	COG0483	inositol monophosphate 1-phosphatase activity
G4D59_RS06965	COG1595	DNA-templated transcription, initiation
G4D59_RS06985	COG1217	gtp-binding protein TYPA
G4D59_RS06995	COG4896	Protein conserved in bacteria
G4D59_RS07005	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G4D59_RS07010	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G4D59_RS07015	COG2066	Belongs to the glutaminase family
G4D59_RS07020	COG4838	Belongs to the UPF0358 family
G4D59_RS07025	COG0772	Belongs to the SEDS family
G4D59_RS07030	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G4D59_RS07035	COG0415	Belongs to the DNA photolyase family
G4D59_RS07040	COG1612	heme a metabolic process
G4D59_RS07045	COG0109	protoheme IX farnesyltransferase activity
G4D59_RS07050	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G4D59_RS07050	COG2010	Cytochrome c
G4D59_RS07055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G4D59_RS07060	COG1845	cytochrome c oxidase, subunit III
G4D59_RS07065	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G4D59_RS07070	COG3336	cytochrome c oxidase
G4D59_RS07080	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
G4D59_RS07085	COG2340	Cysteine-rich secretory protein family
G4D59_RS07105	COG3679	Belongs to the UPF0342 family
G4D59_RS07110	COG4471	UPF0298 protein
G4D59_RS07115	COG0742	ribosomal rna small subunit methyltransferase
G4D59_RS07120	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G4D59_RS07125	COG3314	Sporulation integral membrane protein YlbJ
G4D59_RS07130	COG1752	Esterase of the alpha-beta hydrolase superfamily
G4D59_RS07135	COG3480	Lon protease (S16) C-terminal proteolytic domain
G4D59_RS07145	COG1399	metal-binding, possibly nucleic acid-binding protein
G4D59_RS07150	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G4D59_RS07160	COG0454	-acetyltransferase
G4D59_RS07165	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G4D59_RS07170	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
G4D59_RS07175	COG2001	Belongs to the MraZ family
G4D59_RS07180	COG0275	rRNA processing
G4D59_RS07185	COG4839	cell division protein FtsL
G4D59_RS07190	COG0768	penicillin binding
G4D59_RS07195	COG0768	penicillin binding
G4D59_RS07200	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G4D59_RS07205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G4D59_RS07210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G4D59_RS07215	COG0772	Belongs to the SEDS family
G4D59_RS07220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G4D59_RS07225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G4D59_RS07230	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G4D59_RS07235	COG3879	Bacterial protein of unknown function (DUF881)
G4D59_RS07240	COG3879	Bacterial protein of unknown function (DUF881)
G4D59_RS07245	COG3856	small basic protein
G4D59_RS07250	COG0849	cell division
G4D59_RS07255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G4D59_RS07260	COG1404	Belongs to the peptidase S8 family
G4D59_RS07260	COG4412	M6 family metalloprotease domain protein
G4D59_RS07270	COG1191	sigma factor activity
G4D59_RS07275	COG1191	sigma factor activity
G4D59_RS07280	COG2390	Transcriptional regulator
G4D59_RS07295	COG3730	PTS system glucitol sorbitol-specific
G4D59_RS07300	COG3732	PTS system glucitol sorbitol-specific
G4D59_RS07310	COG1119	ATPase activity
G4D59_RS07315	COG1873	PFAM PRC-barrel domain
G4D59_RS07320	COG1496	oxidoreductase activity
G4D59_RS07325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G4D59_RS07330	COG1799	cell septum assembly
G4D59_RS07335	COG0762	integral membrane protein
G4D59_RS07340	COG2302	S4 RNA-binding domain
G4D59_RS07345	COG3599	regulation of cell shape
G4D59_RS07350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G4D59_RS07355	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G4D59_RS07360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G4D59_RS07365	COG0564	pseudouridine synthase activity
G4D59_RS07370	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
G4D59_RS07375	COG2233	PERMEase
G4D59_RS07380	COG0540	Belongs to the ATCase OTCase family
G4D59_RS07385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G4D59_RS07390	COG0505	Belongs to the CarA family
G4D59_RS07395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G4D59_RS07400	COG0543	2 iron, 2 sulfur cluster binding
G4D59_RS07405	COG0167	dihydroorotate dehydrogenase activity
G4D59_RS07410	COG0284	orotidine-5'-phosphate decarboxylase activity
G4D59_RS07415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G4D59_RS07425	COG0175	sulfate reduction
G4D59_RS07430	COG0306	phosphate transporter
G4D59_RS07435	COG2046	Belongs to the sulfate adenylyltransferase family
G4D59_RS07440	COG0529	Catalyzes the synthesis of activated sulfate
G4D59_RS07445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G4D59_RS07450	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
G4D59_RS07455	COG1648	precorrin-2 dehydrogenase activity
G4D59_RS07465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G4D59_RS07470	COG1561	YicC-like family, N-terminal region
G4D59_RS07475	COG2052	Domain of unknown function (DUF370)
G4D59_RS07480	COG0194	GDP metabolic process
G4D59_RS07485	COG1758	RNA polymerase activity
G4D59_RS07490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G4D59_RS07495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G4D59_RS07500	COG0242	peptide deformylase activity
G4D59_RS07505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G4D59_RS07510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G4D59_RS07510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4D59_RS07515	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G4D59_RS07520	COG0631	protein serine/threonine phosphatase activity
G4D59_RS07525	COG0515	serine threonine protein kinase
G4D59_RS07525	COG2815	serine threonine protein kinase
G4D59_RS07530	COG1162	GTPase activity
G4D59_RS07535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G4D59_RS07540	COG1564	THIamine pyrophosphokinase
G4D59_RS07550	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G4D59_RS07555	COG1302	Protein conserved in bacteria
G4D59_RS07560	COG1461	Dihydroxyacetone kinase
G4D59_RS07565	COG1760	l-serine dehydratase
G4D59_RS07570	COG1760	l-serine dehydratase
G4D59_RS07575	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G4D59_RS07580	COG1349	DNA-binding transcription factor activity
G4D59_RS07585	COG0416	fatty acid biosynthetic process
G4D59_RS07590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G4D59_RS07595	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS07600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4D59_RS07610	COG1196	nuclear chromosome segregation
G4D59_RS07615	COG0552	protein localization to endoplasmic reticulum
G4D59_RS07620	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
G4D59_RS07625	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G4D59_RS07630	COG0228	four-way junction DNA binding
G4D59_RS07635	COG1837	Belongs to the UPF0109 family
G4D59_RS07645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G4D59_RS07650	COG0336	Belongs to the RNA methyltransferase TrmD family
G4D59_RS07655	COG0335	large ribosomal subunit rRNA binding
G4D59_RS07660	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
G4D59_RS07665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G4D59_RS07675	COG2257	FlhB HrpN YscU SpaS Family
G4D59_RS07680	COG0045	succinate-CoA ligase (ADP-forming) activity
G4D59_RS07685	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G4D59_RS07690	COG0758	DNA mediated transformation
G4D59_RS07695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4D59_RS07700	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
G4D59_RS07705	COG4974	Belongs to the 'phage' integrase family
G4D59_RS07710	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G4D59_RS07715	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G4D59_RS07720	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
G4D59_RS07725	COG1815	bacterial-type flagellum-dependent cell motility
G4D59_RS07730	COG1558	bacterial-type flagellum-dependent cell motility
G4D59_RS07735	COG1677	Flagellar hook-basal body complex protein FliE
G4D59_RS07740	COG1766	The M ring may be actively involved in energy transduction
G4D59_RS07745	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G4D59_RS07750	COG1317	bacterial-type flagellum organization
G4D59_RS07755	COG1157	protein secretion by the type III secretion system
G4D59_RS07760	COG2882	bacterial-type flagellum organization
G4D59_RS07765	COG3334	PFAM MgtE intracellular
G4D59_RS07770	COG3144	bacterial-type flagellum assembly
G4D59_RS07775	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G4D59_RS07780	COG4786	Flagellar basal body rod
G4D59_RS07785	COG1582	Flagellar protein (FlbD)
G4D59_RS07790	COG1580	Controls the rotational direction of flagella during chemotaxis
G4D59_RS07795	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G4D59_RS07800	COG1776	CheC inhibitor of MCP methylation
G4D59_RS07800	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G4D59_RS07805	COG2201	protein-glutamate methylesterase activity
G4D59_RS07810	COG3190	flagellar
G4D59_RS07815	COG1338	Plays a role in the flagellum-specific transport system
G4D59_RS07820	COG1987	bacterial-type flagellum assembly
G4D59_RS07825	COG1684	flagellar biosynthetic protein fliR
G4D59_RS07830	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G4D59_RS07835	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G4D59_RS07840	COG1419	protein localization to endoplasmic reticulum
G4D59_RS07845	COG0455	bacterial-type flagellum organization
G4D59_RS07850	COG2201	protein-glutamate methylesterase activity
G4D59_RS07855	COG0643	Histidine kinase
G4D59_RS07855	COG2198	Histidine kinase
G4D59_RS07860	COG0835	chemotaxis
G4D59_RS07865	COG1776	CheC inhibitor of MCP methylation
G4D59_RS07875	COG1191	sigma factor activity
G4D59_RS07890	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G4D59_RS07895	COG0528	UMP kinase activity
G4D59_RS07900	COG0233	cytoplasmic translational termination
G4D59_RS07905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G4D59_RS07910	COG4589	Belongs to the CDS family
G4D59_RS07915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G4D59_RS07920	COG0750	zinc metalloprotease
G4D59_RS07925	COG0442	prolyl-tRNA aminoacylation
G4D59_RS07930	COG2176	DNA-directed DNA polymerase activity
G4D59_RS07945	COG3693	PFAM glycoside hydrolase, family 10
G4D59_RS07955	COG0779	Required for maturation of 30S ribosomal subunits
G4D59_RS07960	COG0195	Participates in both transcription termination and antitermination
G4D59_RS07965	COG2740	Nucleic-acid-binding protein implicated in transcription termination
G4D59_RS07970	COG1358	cellular component organization or biogenesis
G4D59_RS07975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G4D59_RS07980	COG1550	Protein conserved in bacteria
G4D59_RS07985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G4D59_RS07990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G4D59_RS07995	COG0196	riboflavin kinase activity
G4D59_RS08000	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G4D59_RS08005	COG1185	polyribonucleotide nucleotidyltransferase activity
G4D59_RS08010	COG0726	polysaccharide deacetylase
G4D59_RS08015	COG0612	Peptidase, M16
G4D59_RS08025	COG1873	PFAM PRC-barrel domain
G4D59_RS08030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4D59_RS08035	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G4D59_RS08040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G4D59_RS08045	COG0527	aspartate kinase activity
G4D59_RS08055	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
G4D59_RS08060	COG0740	serine-type endopeptidase activity
G4D59_RS08070	COG1674	ftsk spoiiie
G4D59_RS08070	COG4980	gas vesicle protein
G4D59_RS08075	COG2188	Transcriptional regulator
G4D59_RS08080	COG2814	Major facilitator Superfamily
G4D59_RS08085	COG2409	Drug exporters of the RND superfamily
G4D59_RS08085	COG1033	growth of symbiont in host cell
G4D59_RS08090	COG0612	Peptidase, M16
G4D59_RS08095	COG0612	Peptidase, M16
G4D59_RS08105	COG1033	growth of symbiont in host cell
G4D59_RS08105	COG2409	Drug exporters of the RND superfamily
G4D59_RS08110	COG0300	oxidoreductase activity
G4D59_RS08125	COG1426	Protein conserved in bacteria
G4D59_RS08130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G4D59_RS08135	COG1058	Belongs to the CinA family
G4D59_RS08135	COG1546	Belongs to the CinA family
G4D59_RS08140	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G4D59_RS08145	COG1418	mRNA catabolic process
G4D59_RS08150	COG1692	metallophosphoesterase
G4D59_RS08155	COG2359	stage V sporulation protein S
G4D59_RS08160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4D59_RS08165	COG1063	alcohol dehydrogenase
G4D59_RS08170	COG0156	8-amino-7-oxononanoate synthase activity
G4D59_RS08175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G4D59_RS08180	COG4550	Control of competence regulator ComK, YlbF/YmcA
G4D59_RS08190	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G4D59_RS08195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G4D59_RS08215	COG1329	Transcriptional regulator
G4D59_RS08220	COG4195	phage-related replication protein
G4D59_RS08225	COG0457	Tetratricopeptide repeat
G4D59_RS08230	COG1404	Belongs to the peptidase S8 family
G4D59_RS08235	COG4195	phage-related replication protein
G4D59_RS08240	COG1764	response to oxidative stress
G4D59_RS08270	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G4D59_RS08275	COG1923	regulation of RNA biosynthetic process
G4D59_RS08290	COG1780	Probably involved in ribonucleotide reductase function
G4D59_RS08295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4D59_RS08300	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4D59_RS08305	COG4112	unkown
G4D59_RS08315	COG0464	growth
G4D59_RS08320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G4D59_RS08325	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
G4D59_RS08330	COG0789	Transcriptional regulator
G4D59_RS08335	COG0174	glutamine synthetase
G4D59_RS08355	COG0457	Tetratricopeptide repeat
G4D59_RS08375	COG5444	nuclease activity
G4D59_RS08400	COG5646	InterPro IPR014922
G4D59_RS08420	COG0457	Tetratricopeptide repeat
G4D59_RS08430	COG3619	membrane
G4D59_RS08435	COG1793	dna ligase
G4D59_RS08435	COG3285	dna ligase
G4D59_RS08440	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
G4D59_RS08445	COG4876	unkown
G4D59_RS08455	COG1959	2 iron, 2 sulfur cluster binding
G4D59_RS08460	COG0702	epimerase
G4D59_RS08470	COG0247	lactate metabolic process
G4D59_RS08475	COG1139	Iron-sulfur cluster binding protein
G4D59_RS08480	COG1556	Lactate utilization protein
G4D59_RS08500	COG2323	membrane
G4D59_RS08505	COG1309	transcriptional regulator
G4D59_RS08510	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G4D59_RS08510	COG2124	cytochrome p450
G4D59_RS08515	COG3591	Belongs to the peptidase S1B family
G4D59_RS08520	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G4D59_RS08525	COG3209	COG3209 Rhs family protein
G4D59_RS08530	COG1366	Belongs to the anti-sigma-factor antagonist family
G4D59_RS08545	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G4D59_RS08550	COG1388	LysM domain
G4D59_RS08555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G4D59_RS08560	COG4224	UPF0291 protein
G4D59_RS08565	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G4D59_RS08575	COG3763	UPF0154 protein
G4D59_RS08585	COG0785	Cytochrome C biogenesis protein
G4D59_RS08590	COG4846	Membrane protein involved in cytochrome C biogenesis
G4D59_RS08600	COG0071	Belongs to the small heat shock protein (HSP20) family
G4D59_RS08615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G4D59_RS08620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4D59_RS08640	COG0824	Thioesterase
G4D59_RS08650	COG4841	protein insertion into membrane
G4D59_RS08655	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G4D59_RS08660	COG1832	CoA-binding protein
G4D59_RS08665	COG0187	DNA topoisomerase II activity
G4D59_RS08670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G4D59_RS08680	COG0738	Major facilitator superfamily
G4D59_RS08685	COG0473	3-isopropylmalate dehydrogenase activity
G4D59_RS08695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4D59_RS08700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G4D59_RS08705	COG0640	Transcriptional regulator
G4D59_RS08715	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G4D59_RS08720	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G4D59_RS08730	COG1309	transcriptional regulator
G4D59_RS08735	COG2249	NAD(P)H dehydrogenase (quinone) activity
G4D59_RS08740	COG1733	regulation of RNA biosynthetic process
G4D59_RS08745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4D59_RS08750	COG0251	oxidation-reduction process
G4D59_RS08790	COG0657	acetylesterase activity
G4D59_RS08800	COG2723	6-phospho-beta-galactosidase activity
G4D59_RS08805	COG1263	PTS System
G4D59_RS08805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4D59_RS08805	COG2190	(PTS) system
G4D59_RS08820	COG2205	protein histidine kinase activity
G4D59_RS08825	COG0745	RESPONSE REGULATOR receiver
G4D59_RS08835	COG3507	Belongs to the glycosyl hydrolase 43 family
G4D59_RS08840	COG1012	belongs to the aldehyde dehydrogenase family
G4D59_RS08845	COG1486	melibiose metabolic process
G4D59_RS08850	COG0395	ABC-type sugar transport system, permease component
G4D59_RS08855	COG1175	transmembrane transport
G4D59_RS08860	COG1653	transport
G4D59_RS08865	COG1609	Transcriptional regulator
G4D59_RS08870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G4D59_RS08885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4D59_RS08920	COG5444	nuclease activity
G4D59_RS08925	COG1846	Transcriptional regulator
G4D59_RS08930	COG2814	Major facilitator Superfamily
G4D59_RS08940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4D59_RS08940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4D59_RS08940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4D59_RS08945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4D59_RS08945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4D59_RS08945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4D59_RS08950	COG1105	Belongs to the carbohydrate kinase PfkB family
G4D59_RS08960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4D59_RS08980	COG1012	belongs to the aldehyde dehydrogenase family
G4D59_RS08985	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G4D59_RS08990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4D59_RS08995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4D59_RS09000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4D59_RS09005	COG1024	Enoyl-CoA hydratase
G4D59_RS09010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4D59_RS09015	COG0511	ligase activity, forming carbon-carbon bonds
G4D59_RS09020	COG0439	Biotin carboxylase
G4D59_RS09025	COG0318	PFAM AMP-dependent synthetase and ligase
G4D59_RS09030	COG1960	acyl-CoA dehydrogenase activity
G4D59_RS09035	COG1649	PFAM Uncharacterised BCR, COG1649
G4D59_RS09040	COG2365	Tyrosine phosphatase family
G4D59_RS09045	COG1349	DNA-binding transcription factor activity
G4D59_RS09050	COG1942	4-Oxalocrotonate Tautomerase
G4D59_RS09060	COG3835	regulator
G4D59_RS09065	COG0277	FAD linked oxidase domain protein
G4D59_RS09070	COG0247	lactate metabolic process
G4D59_RS09090	COG0166	Belongs to the GPI family
G4D59_RS09095	COG2246	polysaccharide biosynthetic process
G4D59_RS09100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G4D59_RS09105	COG0586	Pfam SNARE associated Golgi protein
G4D59_RS09110	COG1587	Uroporphyrinogen-III synthase
G4D59_RS09120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4D59_RS09135	COG0534	Mate efflux family protein
G4D59_RS09140	COG2027	D-alanyl-D-alanine carboxypeptidase
G4D59_RS09145	COG4677	pectinesterase activity
G4D59_RS09150	COG2323	membrane
G4D59_RS09155	COG2146	nitrite reductase [NAD(P)H] activity
G4D59_RS09160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4D59_RS09165	COG0243	molybdopterin cofactor binding
G4D59_RS09170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4D59_RS09175	COG2223	nitrite transmembrane transporter activity
G4D59_RS09180	COG0493	'glutamate synthase
G4D59_RS09185	COG0070	glutamate synthase
G4D59_RS09185	COG0069	glutamate synthase activity
G4D59_RS09185	COG0067	glutamate synthase
G4D59_RS09190	COG0583	DNA-binding transcription factor activity
G4D59_RS09200	COG1132	(ABC) transporter
G4D59_RS09205	COG0789	Transcriptional regulator
G4D59_RS09205	COG4978	Transcriptional regulator
G4D59_RS09210	COG0454	-acetyltransferase
G4D59_RS09215	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G4D59_RS09220	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G4D59_RS09225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G4D59_RS09235	COG0243	molybdopterin cofactor binding
G4D59_RS09245	COG1070	Carbohydrate kinase
G4D59_RS09250	COG2115	Belongs to the xylose isomerase family
G4D59_RS09255	COG1940	carbohydrate kinase activity
G4D59_RS09265	COG2211	Major facilitator Superfamily
G4D59_RS09270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4D59_RS09275	COG1994	Peptidase M50
G4D59_RS09295	COG1309	transcriptional regulator
G4D59_RS09300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4D59_RS09305	COG3708	Transcriptional regulator
G4D59_RS09310	COG2378	regulation of single-species biofilm formation
G4D59_RS09320	COG0640	Transcriptional regulator
G4D59_RS09325	COG0531	amino acid
G4D59_RS09330	COG0741	lytic transglycosylase activity
G4D59_RS09335	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
G4D59_RS09340	COG2079	MmgE PrpD family protein
G4D59_RS09345	COG0372	Belongs to the citrate synthase family
G4D59_RS09350	COG2322	membrane
G4D59_RS09360	COG1388	LysM domain
G4D59_RS09360	COG3584	3D domain protein
G4D59_RS09365	COG0514	ATP-dependent DNA helicase (RecQ)
G4D59_RS09375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G4D59_RS09400	COG1012	belongs to the aldehyde dehydrogenase family
G4D59_RS09405	COG1657	PFAM Prenyltransferase squalene oxidase
G4D59_RS09410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G4D59_RS09415	COG0385	Bile acid
G4D59_RS09420	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4D59_RS09425	COG0567	Dehydrogenase, E1 component
G4D59_RS09430	COG4548	von Willebrand factor, type A
G4D59_RS09435	COG0714	Associated with various cellular activities
G4D59_RS09440	COG2032	superoxide dismutase activity
G4D59_RS09445	COG0791	NLP P60 protein
G4D59_RS09445	COG1388	LysM domain
G4D59_RS09450	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
G4D59_RS09455	COG0534	Mate efflux family protein
G4D59_RS09460	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4D59_RS09465	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4D59_RS09475	COG2962	Rard protein
G4D59_RS09490	COG1733	regulation of RNA biosynthetic process
G4D59_RS09495	COG0778	Nitroreductase
G4D59_RS09505	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4D59_RS09510	COG0793	Belongs to the peptidase S41A family
G4D59_RS09510	COG3409	Peptidoglycan-binding domain 1 protein
G4D59_RS09515	COG2226	methyltransferase
G4D59_RS09530	COG1876	peptidase activity
G4D59_RS09535	COG0813	purine-nucleoside phosphorylase activity
G4D59_RS09545	COG0671	phosphoesterase, PA-phosphatase related
G4D59_RS09565	COG4479	Belongs to the UPF0346 family
G4D59_RS09575	COG1509	lysine 2,3-aminomutase activity
G4D59_RS09580	COG3829	transcription factor binding
G4D59_RS09585	COG0463	Glycosyl transferase, family 2
G4D59_RS09600	COG4641	Protein conserved in bacteria
G4D59_RS09610	COG1086	Polysaccharide biosynthesis protein
G4D59_RS09615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G4D59_RS09620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G4D59_RS09625	COG1846	Transcriptional regulator
G4D59_RS09645	COG4698	Protein conserved in bacteria
G4D59_RS09650	COG2755	lipolytic protein G-D-S-L family
G4D59_RS09655	COG1999	signal sequence binding
G4D59_RS09670	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G4D59_RS09675	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
G4D59_RS09680	COG1272	protein, Hemolysin III
G4D59_RS09685	COG0204	Acyl-transferase
G4D59_RS09690	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G4D59_RS09695	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G4D59_RS09700	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G4D59_RS09710	COG2136	Putative SAM-dependent methyltransferase
G4D59_RS09710	COG2521	methyltransferase
G4D59_RS09720	COG0129	dihydroxy-acid dehydratase activity
G4D59_RS09725	COG1413	lyase activity
G4D59_RS09730	COG1418	mRNA catabolic process
G4D59_RS09735	COG0386	Belongs to the glutathione peroxidase family
G4D59_RS09740	COG2759	Belongs to the formate--tetrahydrofolate ligase family
G4D59_RS09745	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
G4D59_RS09750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G4D59_RS09760	COG1278	Cold shock
G4D59_RS09775	COG0328	RNA-DNA hybrid ribonuclease activity
G4D59_RS09780	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G4D59_RS09785	COG0328	RNA-DNA hybrid ribonuclease activity
G4D59_RS09795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4D59_RS09805	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
G4D59_RS09815	COG1755	Isoprenylcysteine carboxyl methyltransferase
G4D59_RS09820	COG3424	synthase
G4D59_RS09825	COG0456	acetyltransferase
G4D59_RS09825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
G4D59_RS09830	COG0726	polysaccharide deacetylase
G4D59_RS09835	COG2233	PERMEase
G4D59_RS09840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G4D59_RS09845	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
G4D59_RS09850	COG1199	ATP-dependent helicase activity
G4D59_RS09860	COG0116	Belongs to the methyltransferase superfamily
G4D59_RS09870	COG3599	regulation of cell shape
G4D59_RS09875	COG4474	Belongs to the UPF0398 family
G4D59_RS09885	COG3359	exonuclease
G4D59_RS09890	COG1111	helicase
G4D59_RS09890	COG1205	dead DEAH box helicase
G4D59_RS09895	COG1902	pentaerythritol trinitrate reductase activity
G4D59_RS09900	COG2190	(PTS) system
G4D59_RS09905	COG0071	Belongs to the small heat shock protein (HSP20) family
G4D59_RS09935	COG3331	DNA recombination
G4D59_RS09940	COG4499	WXG100 protein secretion system (Wss), protein YukC
G4D59_RS09940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4D59_RS09950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G4D59_RS09955	COG3935	DnaD domain protein
G4D59_RS09960	COG0017	Asparaginyl-tRNA synthetase
G4D59_RS09965	COG5353	protein conserved in bacteria
G4D59_RS09975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G4D59_RS09975	COG1199	ATP-dependent helicase activity
G4D59_RS09980	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G4D59_RS09985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G4D59_RS09990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G4D59_RS10000	COG0617	tRNA 3'-terminal CCA addition
G4D59_RS10005	COG0438	transferase activity, transferring glycosyl groups
G4D59_RS10010	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4D59_RS10015	COG1803	Methylglyoxal synthase
G4D59_RS10020	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G4D59_RS10025	COG1694	Mazg nucleotide pyrophosphohydrolase
G4D59_RS10030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4D59_RS10040	COG4347	Protein of unknown function (DUF1405)
G4D59_RS10045	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G4D59_RS10045	COG2010	Cytochrome c
G4D59_RS10050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G4D59_RS10055	COG0723	plastoquinol--plastocyanin reductase activity
G4D59_RS10065	COG5582	Belongs to the UPF0302 family
G4D59_RS10070	COG0457	Tetratricopeptide repeat
G4D59_RS10075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G4D59_RS10080	COG0287	Prephenate dehydrogenase
G4D59_RS10085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G4D59_RS10090	COG0159	tryptophan synthase activity
G4D59_RS10095	COG0133	tryptophan synthase activity
G4D59_RS10100	COG0135	phosphoribosylanthranilate isomerase activity
G4D59_RS10105	COG0134	indole-3-glycerol-phosphate synthase activity
G4D59_RS10110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G4D59_RS10120	COG4401	Chorismate mutase type I
G4D59_RS10125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G4D59_RS10130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G4D59_RS10135	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G4D59_RS10140	COG0105	UTP biosynthetic process
G4D59_RS10145	COG0142	geranyltranstransferase activity
G4D59_RS10150	COG2226	methyltransferase
G4D59_RS10155	COG0142	geranyltranstransferase activity
G4D59_RS10165	COG0302	gtp cyclohydrolase
G4D59_RS10170	COG0776	regulation of translation
G4D59_RS10175	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
G4D59_RS10190	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G4D59_RS10195	COG1160	GTP binding
G4D59_RS10220	COG1304	FMN binding
G4D59_RS10225	COG0539	negative regulation of cytoplasmic translation
G4D59_RS10230	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G4D59_RS10240	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
G4D59_RS10245	COG2959	enzyme of heme biosynthesis
G4D59_RS10250	COG3409	Peptidoglycan-binding domain 1 protein
G4D59_RS10250	COG3773	Cell wall hydrolase
G4D59_RS10255	COG2339	peptidase activity
G4D59_RS10260	COG0492	ferredoxin-NADP+ reductase activity
G4D59_RS10265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G4D59_RS10270	COG4862	establishment of competence for transformation
G4D59_RS10275	COG1408	metallophosphoesterase
G4D59_RS10285	COG1388	LysM domain
G4D59_RS10290	COG1266	CAAX protease self-immunity
G4D59_RS10295	COG0514	ATP-dependent DNA helicase (RecQ)
G4D59_RS10300	COG4955	Helix-turn-helix domain
G4D59_RS10305	COG1141	Ferredoxin
G4D59_RS10310	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
G4D59_RS10315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G4D59_RS10330	COG1595	DNA-templated transcription, initiation
G4D59_RS10335	COG5002	protein histidine kinase activity
G4D59_RS10340	COG0745	RESPONSE REGULATOR receiver
G4D59_RS10345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G4D59_RS10350	COG1333	cytochrome c biogenesis protein
G4D59_RS10355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4D59_RS10360	COG1187	pseudouridine synthase activity
G4D59_RS10365	COG0700	Nucleoside recognition
G4D59_RS10370	COG2715	membrane protein required for spore maturation
G4D59_RS10375	COG1686	Belongs to the peptidase S11 family
G4D59_RS10385	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G4D59_RS10390	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G4D59_RS10400	COG1547	Domain of unknown function (DUF309)
G4D59_RS10405	COG0456	acetyltransferase
G4D59_RS10410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G4D59_RS10420	COG0307	riboflavin synthase, alpha
G4D59_RS10440	COG2814	Major facilitator Superfamily
G4D59_RS10445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G4D59_RS10450	COG4086	secreted protein
G4D59_RS10455	COG0019	diaminopimelate decarboxylase activity
G4D59_RS10460	COG0697	spore germination
G4D59_RS10475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4D59_RS10495	COG1191	sigma factor activity
G4D59_RS10500	COG2172	sigma factor antagonist activity
G4D59_RS10510	COG1686	Belongs to the peptidase S11 family
G4D59_RS10515	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
G4D59_RS10520	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
G4D59_RS10525	COG4974	Belongs to the 'phage' integrase family
G4D59_RS10535	COG0735	belongs to the Fur family
G4D59_RS10540	COG1300	Membrane
G4D59_RS10545	COG1404	Belongs to the peptidase S8 family
G4D59_RS10555	COG2153	protein acetylation
G4D59_RS10560	COG1379	DNA repair
G4D59_RS10565	COG0494	nUDIX hydrolase
G4D59_RS10570	COG0667	Aldo Keto reductase
G4D59_RS10580	COG1073	alpha beta
G4D59_RS10585	COG0457	Tetratricopeptide repeat
G4D59_RS10595	COG4918	Iron-sulphur cluster biosynthesis
G4D59_RS10600	COG4305	rare lipoprotein A
G4D59_RS10605	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
G4D59_RS10605	COG0456	acetyltransferase
G4D59_RS10610	COG0456	acetyltransferase
G4D59_RS10620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4D59_RS10630	COG2211	Major facilitator Superfamily
G4D59_RS10635	COG1072	(Pantothenic acid kinase))
G4D59_RS10640	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4D59_RS10650	COG0300	oxidoreductase activity
G4D59_RS10655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4D59_RS10660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G4D59_RS10680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4D59_RS10685	COG4187	Peptidase family M20/M25/M40
G4D59_RS10690	COG1902	pentaerythritol trinitrate reductase activity
G4D59_RS10695	COG0596	Alpha beta hydrolase
G4D59_RS10700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4D59_RS10710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G4D59_RS10715	COG2188	Transcriptional regulator
G4D59_RS10720	COG2723	6-phospho-beta-galactosidase activity
G4D59_RS10725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4D59_RS10730	COG1447	Phosphotransferase system cellobiose-specific component IIA
G4D59_RS10735	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4D59_RS10745	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS10755	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G4D59_RS10760	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4D59_RS10770	COG0706	membrane insertase activity
G4D59_RS10775	COG0835	chemotaxis
G4D59_RS10780	COG2195	Cleaves the N-terminal amino acid of tripeptides
G4D59_RS10785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4D59_RS10790	COG0346	lactoylglutathione lyase activity
G4D59_RS10800	COG1376	ErfK ybiS ycfS ynhG family protein
G4D59_RS10805	COG4129	membrane
G4D59_RS10810	COG1126	abc transporter atp-binding protein
G4D59_RS10815	COG0765	amino acid transport
G4D59_RS10820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4D59_RS10830	COG1597	lipid kinase activity
G4D59_RS10840	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4D59_RS10845	COG0022	dehydrogenase e1 component
G4D59_RS10850	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G4D59_RS10855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4D59_RS10860	COG3426	butyrate kinase activity
G4D59_RS10865	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G4D59_RS10870	COG0280	phosphate acetyltransferase
G4D59_RS10875	COG3290	protein histidine kinase activity
G4D59_RS10875	COG3829	transcription factor binding
G4D59_RS10885	COG0584	glycerophosphoryl diester phosphodiesterase
G4D59_RS10890	COG0457	Tetratricopeptide repeat
G4D59_RS10895	COG0745	RESPONSE REGULATOR receiver
G4D59_RS10900	COG0750	zinc metalloprotease
G4D59_RS10905	COG0497	DNA recombination
G4D59_RS10910	COG1438	arginine binding
G4D59_RS10915	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
G4D59_RS10920	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G4D59_RS10925	COG0142	geranyltranstransferase activity
G4D59_RS10930	COG1722	exodeoxyribonuclease VII activity
G4D59_RS10935	COG1570	exodeoxyribonuclease VII activity
G4D59_RS10940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G4D59_RS10945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4D59_RS10950	COG1302	Protein conserved in bacteria
G4D59_RS10955	COG0439	Biotin carboxylase
G4D59_RS10960	COG0511	ligase activity, forming carbon-carbon bonds
G4D59_RS11000	COG3854	ATPases associated with a variety of cellular activities
G4D59_RS11010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G4D59_RS11015	COG0006	proline dipeptidase activity
G4D59_RS11020	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G4D59_RS11030	COG3872	metal-dependent enzyme
G4D59_RS11040	COG1752	Esterase of the alpha-beta hydrolase superfamily
G4D59_RS11045	COG1321	iron dependent repressor
G4D59_RS11050	COG0095	Lipoate-protein ligase
G4D59_RS11055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4D59_RS11060	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G4D59_RS11065	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G4D59_RS11070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G4D59_RS11075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G4D59_RS11100	COG0681	Belongs to the peptidase S26 family
G4D59_RS11135	COG4970	Tfp pilus assembly protein FimT
G4D59_RS11140	COG4537	Required for transformation and DNA binding
G4D59_RS11145	COG1459	type II secretion system
G4D59_RS11150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G4D59_RS11155	COG1366	Belongs to the anti-sigma-factor antagonist family
G4D59_RS11165	COG1393	Belongs to the ArsC family
G4D59_RS11175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4D59_RS11185	COG0011	TIGRFAM Protein of
G4D59_RS11190	COG2814	Major facilitator Superfamily
G4D59_RS11195	COG2866	Carboxypeptidase
G4D59_RS11200	COG1368	sulfuric ester hydrolase activity
G4D59_RS11205	COG1940	carbohydrate kinase activity
G4D59_RS11210	COG4483	Protein conserved in bacteria
G4D59_RS11215	COG0457	Tetratricopeptide repeat
G4D59_RS11215	COG0705	Rhomboid family
G4D59_RS11230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G4D59_RS11235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G4D59_RS11245	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G4D59_RS11250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G4D59_RS11255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G4D59_RS11260	COG0581	inorganic phosphate transmembrane transporter activity
G4D59_RS11265	COG0573	inorganic phosphate transmembrane transporter activity
G4D59_RS11270	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G4D59_RS11275	COG0768	penicillin binding
G4D59_RS11280	COG0477	Major facilitator Superfamily
G4D59_RS11285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G4D59_RS11290	COG2839	Protein conserved in bacteria
G4D59_RS11295	COG5521	maltodextrose utilization protein MalA
G4D59_RS11300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4D59_RS11305	COG1388	LysM domain
G4D59_RS11310	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G4D59_RS11315	COG4709	membrane
G4D59_RS11320	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
G4D59_RS11325	COG1940	carbohydrate kinase activity
G4D59_RS11330	COG0735	belongs to the Fur family
G4D59_RS11335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4D59_RS11340	COG1121	(ABC) transporter
G4D59_RS11345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4D59_RS11360	COG0513	Belongs to the DEAD box helicase family
G4D59_RS11370	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G4D59_RS11375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G4D59_RS11380	COG2384	SAM-dependent methyltransferase
G4D59_RS11385	COG2010	Cytochrome c
G4D59_RS11390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4D59_RS11395	COG0358	DNA primase activity
G4D59_RS11400	COG1671	Belongs to the UPF0178 family
G4D59_RS11405	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G4D59_RS11410	COG0517	IMP dehydrogenase activity
G4D59_RS11415	COG0751	glycine-tRNA ligase activity
G4D59_RS11420	COG0752	glycyl-tRNA synthetase alpha subunit
G4D59_RS11425	COG1381	Involved in DNA repair and RecF pathway recombination
G4D59_RS11435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G4D59_RS11440	COG0295	cytidine deaminase activity
G4D59_RS11445	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G4D59_RS11450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G4D59_RS11455	COG1480	7TM receptor with intracellular HD hydrolase
G4D59_RS11460	COG1702	phosphate starvation-inducible protein PhoH
G4D59_RS11465	COG0561	phosphatase activity
G4D59_RS11480	COG4864	UPF0365 protein
G4D59_RS11485	COG1030	water channel activity
G4D59_RS11490	COG1610	YqeY-like protein
G4D59_RS11500	COG1283	sodium-dependent phosphate transmembrane transporter activity
G4D59_RS11505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G4D59_RS11510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G4D59_RS11515	COG2264	protein methyltransferase activity
G4D59_RS11520	COG0484	heat shock protein binding
G4D59_RS11525	COG0443	Heat shock 70 kDa protein
G4D59_RS11530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G4D59_RS11535	COG1420	regulation of RNA biosynthetic process
G4D59_RS11540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4D59_RS11545	COG0481	GTPase activity
G4D59_RS11555	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4D59_RS11560	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
G4D59_RS11565	COG0268	Binds directly to 16S ribosomal RNA
G4D59_RS11570	COG1466	dna polymerase III delta subunit
G4D59_RS11580	COG0658	competence protein
G4D59_RS11580	COG2333	competence protein COMEC
G4D59_RS11585	COG2131	deaminase
G4D59_RS11590	COG1555	photosystem II stabilization
G4D59_RS11590	COG1596	polysaccharide export
G4D59_RS11595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G4D59_RS11600	COG2226	methyltransferase
G4D59_RS11605	COG0799	negative regulation of ribosome biogenesis
G4D59_RS11610	COG1713	HD superfamily hydrolase involved in NAD metabolism
G4D59_RS11615	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G4D59_RS11620	COG1534	Rna-binding protein
G4D59_RS11625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G4D59_RS11630	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
G4D59_RS11635	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
G4D59_RS11650	COG2755	lipolytic protein G-D-S-L family
G4D59_RS11660	COG0457	Tetratricopeptide repeat
G4D59_RS11690	COG0726	polysaccharide deacetylase
G4D59_RS11725	COG1131	(ABC) transporter
G4D59_RS11750	COG2160	L-arabinose isomerase activity
G4D59_RS11765	COG1609	Transcriptional regulator
G4D59_RS11775	COG1846	Transcriptional regulator
G4D59_RS11785	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
G4D59_RS11790	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
G4D59_RS11795	COG1733	regulation of RNA biosynthetic process
G4D59_RS11800	COG0657	acetylesterase activity
G4D59_RS11865	COG2602	Beta-lactamase
G4D59_RS11870	COG1960	acyl-CoA dehydrogenase activity
G4D59_RS11875	COG1126	abc transporter atp-binding protein
G4D59_RS11880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4D59_RS11885	COG0765	amino acid transport
G4D59_RS11895	COG3546	catalase activity
G4D59_RS11900	COG1063	alcohol dehydrogenase
G4D59_RS11910	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS11920	COG1115	amino acid carrier protein
G4D59_RS11925	COG0583	DNA-binding transcription factor activity
G4D59_RS11930	COG0842	Transport permease protein
G4D59_RS11935	COG1511	domain protein
G4D59_RS11935	COG0842	Transport permease protein
G4D59_RS11940	COG1131	(ABC) transporter
G4D59_RS11945	COG1063	alcohol dehydrogenase
G4D59_RS11950	COG2226	methyltransferase
G4D59_RS11975	COG0626	cystathionine gamma-synthase activity
G4D59_RS11980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4D59_RS11985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G4D59_RS11990	COG2226	methyltransferase
G4D59_RS12005	COG0768	penicillin binding
G4D59_RS12010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4D59_RS12015	COG0572	uridine kinase
G4D59_RS12020	COG0826	peptidase U32
G4D59_RS12025	COG0826	peptidase U32
G4D59_RS12030	COG4122	O-methyltransferase activity
G4D59_RS12035	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G4D59_RS12040	COG0183	Belongs to the thiolase family
G4D59_RS12045	COG0318	PFAM AMP-dependent synthetase and ligase
G4D59_RS12050	COG1268	BioY protein
G4D59_RS12055	COG3906	Belongs to the UPF0473 family
G4D59_RS12060	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G4D59_RS12065	COG4472	Bacterial protein of unknown function (DUF965)
G4D59_RS12070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G4D59_RS12075	COG0628	permease
G4D59_RS12080	COG1126	abc transporter atp-binding protein
G4D59_RS12085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4D59_RS12090	COG0765	amino acid transport
G4D59_RS12095	COG0765	amino acid transport
G4D59_RS12110	COG3881	PFAM PRC-barrel domain
G4D59_RS12115	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G4D59_RS12120	COG0457	Tetratricopeptide repeat
G4D59_RS12125	COG0482	sulfurtransferase activity
G4D59_RS12130	COG1104	cysteine desulfurase activity
G4D59_RS12135	COG1959	2 iron, 2 sulfur cluster binding
G4D59_RS12140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G4D59_RS12145	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G4D59_RS12160	COG0124	histidyl-tRNA synthetase
G4D59_RS12170	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4D59_RS12170	COG3103	Sh3 type 3 domain protein
G4D59_RS12170	COG4991	sh3 domain protein
G4D59_RS12175	COG1490	D-aminoacyl-tRNA deacylase activity
G4D59_RS12180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4D59_RS12185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G4D59_RS12190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G4D59_RS12190	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
G4D59_RS12195	COG5416	Lipopolysaccharide assembly protein A domain
G4D59_RS12200	COG0490	domain, Protein
G4D59_RS12205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4D59_RS12205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4D59_RS12215	COG2244	polysaccharide biosynthetic process
G4D59_RS12220	COG2323	membrane
G4D59_RS12230	COG1862	Preprotein translocase
G4D59_RS12235	COG0343	queuine tRNA-ribosyltransferase activity
G4D59_RS12240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G4D59_RS12250	COG2255	four-way junction helicase activity
G4D59_RS12255	COG0632	four-way junction helicase activity
G4D59_RS12265	COG2112	serine threonine protein kinase
G4D59_RS12280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G4D59_RS12300	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G4D59_RS12305	COG0157	Belongs to the NadC ModD family
G4D59_RS12310	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G4D59_RS12315	COG1104	cysteine desulfurase activity
G4D59_RS12320	COG1827	regulation of RNA biosynthetic process
G4D59_RS12325	COG0077	Prephenate dehydratase
G4D59_RS12330	COG4492	Belongs to the UPF0735 family
G4D59_RS12335	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G4D59_RS12340	COG3290	protein histidine kinase activity
G4D59_RS12345	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G4D59_RS12350	COG2868	ribosomal protein
G4D59_RS12355	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G4D59_RS12360	COG1994	Peptidase M50
G4D59_RS12365	COG0739	heme binding
G4D59_RS12370	COG2894	cell division
G4D59_RS12375	COG0850	regulation of cytokinetic process
G4D59_RS12380	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
G4D59_RS12390	COG1077	Cell shape determining protein MreB Mrl
G4D59_RS12395	COG2003	Belongs to the UPF0758 family
G4D59_RS12400	COG0424	maF-like protein
G4D59_RS12410	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G4D59_RS12415	COG0285	dihydrofolate synthase activity
G4D59_RS12420	COG0525	valine-tRNA ligase activity
G4D59_RS12430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G4D59_RS12435	COG1388	LysM domain
G4D59_RS12440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G4D59_RS12445	COG0113	porphobilinogen synthase activity
G4D59_RS12450	COG1587	Uroporphyrinogen-III synthase
G4D59_RS12455	COG0181	hydroxymethylbilane synthase activity
G4D59_RS12460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G4D59_RS12465	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G4D59_RS12490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G4D59_RS12495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G4D59_RS12500	COG1067	ATP-dependent peptidase activity
G4D59_RS12500	COG0470	DNA polymerase III
G4D59_RS12505	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G4D59_RS12510	COG0544	peptidyl-prolyl cis-trans isomerase activity
G4D59_RS12515	COG0457	Tetratricopeptide repeat
G4D59_RS12515	COG1477	protein flavinylation
G4D59_RS12520	COG0066	3-isopropylmalate dehydratase activity
G4D59_RS12525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G4D59_RS12530	COG0473	3-isopropylmalate dehydrogenase activity
G4D59_RS12535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4D59_RS12540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G4D59_RS12545	COG0440	acetolactate synthase activity
G4D59_RS12550	COG0028	Belongs to the TPP enzyme family
G4D59_RS12555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4D59_RS12560	COG2706	6-phosphogluconolactonase activity
G4D59_RS12565	COG3339	Conserved Protein
G4D59_RS12570	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
G4D59_RS12575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4D59_RS12580	COG1696	Membrane protein involved in D-alanine export
G4D59_RS12585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4D59_RS12620	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
G4D59_RS12625	COG5444	nuclease activity
G4D59_RS12640	COG0622	Phosphoesterase
G4D59_RS12645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G4D59_RS12650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G4D59_RS12655	COG5401	PFAM Sporulation and spore germination
G4D59_RS12660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G4D59_RS12665	COG1846	Transcriptional regulator
G4D59_RS12695	COG3409	Peptidoglycan-binding domain 1 protein
G4D59_RS12695	COG5632	N-Acetylmuramoyl-L-alanine amidase
G4D59_RS12700	COG4824	toxin secretion phage lysis holin
G4D59_RS12730	COG1705	Flagellar rod assembly protein muramidase FlgJ
G4D59_RS12805	COG1802	Transcriptional regulator
G4D59_RS12805	COG4626	Terminase
G4D59_RS12845	COG0582	viral genome integration into host DNA
G4D59_RS12850	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G4D59_RS12950	COG2197	response regulator
G4D59_RS12955	COG2851	Citrate transporter
G4D59_RS12960	COG0583	DNA-binding transcription factor activity
G4D59_RS12965	COG2828	Protein conserved in bacteria
G4D59_RS12975	COG0824	Thioesterase
G4D59_RS12980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G4D59_RS12985	COG1053	succinate dehydrogenase
G4D59_RS12990	COG2009	succinate dehydrogenase
G4D59_RS12995	COG1719	4-vinyl reductase, 4VR
G4D59_RS13000	COG0527	aspartate kinase activity
G4D59_RS13005	COG0322	excinuclease ABC activity
G4D59_RS13010	COG3118	belongs to the thioredoxin family
G4D59_RS13015	COG3534	alpha-L-arabinofuranosidase
G4D59_RS13020	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G4D59_RS13025	COG2086	electron transfer activity
G4D59_RS13030	COG1024	Enoyl-CoA hydratase
G4D59_RS13035	COG1309	transcriptional regulator
G4D59_RS13040	COG0318	PFAM AMP-dependent synthetase and ligase
G4D59_RS13050	COG3766	membrane
G4D59_RS13055	COG1193	negative regulation of DNA recombination
G4D59_RS13060	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
G4D59_RS13060	COG1796	DNA polymerase
G4D59_RS13065	COG1286	toxin biosynthetic process
G4D59_RS13070	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
G4D59_RS13075	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G4D59_RS13080	COG0072	phenylalanine-tRNA ligase activity
G4D59_RS13080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4D59_RS13085	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G4D59_RS13090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4D59_RS13100	COG1966	Carbon starvation protein
G4D59_RS13105	COG1363	Peptidase, m42
G4D59_RS13115	COG3326	Membrane
G4D59_RS13120	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G4D59_RS13125	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G4D59_RS13130	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G4D59_RS13140	COG1011	Hydrolase
G4D59_RS13150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G4D59_RS13160	COG0398	Pfam SNARE associated Golgi protein
G4D59_RS13165	COG1484	DNA-dependent DNA replication
G4D59_RS13170	COG3611	Membrane attachment protein
G4D59_RS13175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G4D59_RS13185	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
G4D59_RS13190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4D59_RS13195	COG0237	dephospho-CoA kinase activity
G4D59_RS13200	COG1971	Probably functions as a manganese efflux pump
G4D59_RS13205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G4D59_RS13210	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4D59_RS13210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4D59_RS13215	COG5002	protein histidine kinase activity
G4D59_RS13220	COG0745	RESPONSE REGULATOR receiver
G4D59_RS13225	COG0039	L-malate dehydrogenase activity
G4D59_RS13230	COG0538	isocitrate dehydrogenase activity
G4D59_RS13235	COG0372	Belongs to the citrate synthase family
G4D59_RS13240	COG2707	UPF0756 membrane protein
G4D59_RS13245	COG0628	permease
G4D59_RS13250	COG3030	protein affecting phage T7 exclusion by the F plasmid
G4D59_RS13260	COG0205	6-phosphofructokinase activity
G4D59_RS13265	COG0825	malonyl-CoA metabolic process
G4D59_RS13270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G4D59_RS13275	COG0281	malic enzyme
G4D59_RS13280	COG0587	DNA-directed DNA polymerase activity
G4D59_RS13300	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G4D59_RS13310	COG4109	DRTGG domain
G4D59_RS13315	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G4D59_RS13320	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS13330	COG0165	Argininosuccinate lyase
G4D59_RS13335	COG0137	argininosuccinate synthase activity
G4D59_RS13340	COG0521	Mo-molybdopterin cofactor biosynthetic process
G4D59_RS13345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G4D59_RS13350	COG0827	DNA restriction-modification system
G4D59_RS13355	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
G4D59_RS13360	COG3874	Sporulation protein YtfJ
G4D59_RS13370	COG1714	RDD family
G4D59_RS13375	COG0616	signal peptide processing
G4D59_RS13380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G4D59_RS13390	COG3239	Fatty acid desaturase
G4D59_RS13395	COG4585	Histidine kinase
G4D59_RS13400	COG2197	response regulator
G4D59_RS13405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4D59_RS13410	COG0745	RESPONSE REGULATOR receiver
G4D59_RS13415	COG2205	protein histidine kinase activity
G4D59_RS13420	COG1136	(ABC) transporter
G4D59_RS13425	COG0577	efflux transmembrane transporter activity
G4D59_RS13430	COG0402	S-adenosylhomocysteine deaminase activity
G4D59_RS13435	COG2249	NAD(P)H dehydrogenase (quinone) activity
G4D59_RS13450	COG1279	arginine transmembrane transporter activity
G4D59_RS13455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4D59_RS13465	COG0301	tRNA thio-modification
G4D59_RS13470	COG1104	cysteine desulfurase activity
G4D59_RS13475	COG1114	Component of the transport system for branched-chain amino acids
G4D59_RS13480	COG1114	Component of the transport system for branched-chain amino acids
G4D59_RS13485	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
G4D59_RS13490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
G4D59_RS13495	COG1309	transcriptional regulator
G4D59_RS13500	COG1956	GAF domain-containing protein
G4D59_RS13505	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G4D59_RS13515	COG1335	isochorismatase
G4D59_RS13525	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
G4D59_RS13530	COG2329	Antibiotic biosynthesis monooxygenase
G4D59_RS13535	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G4D59_RS13540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4D59_RS13545	COG0454	-acetyltransferase
G4D59_RS13550	COG0517	IMP dehydrogenase activity
G4D59_RS13555	COG0123	including yeast histone deacetylase and acetoin utilization protein
G4D59_RS13560	COG1609	Transcriptional regulator
G4D59_RS13565	COG1605	Chorismate mutase
G4D59_RS13565	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
G4D59_RS13570	COG3118	belongs to the thioredoxin family
G4D59_RS13575	COG4980	gas vesicle protein
G4D59_RS13580	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
G4D59_RS13585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G4D59_RS13590	COG1674	ftsk spoiiie
G4D59_RS13595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4D59_RS13600	COG4848	Belongs to the UPF0354 family
G4D59_RS13605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4D59_RS13620	COG1363	Peptidase, m42
G4D59_RS13625	COG5584	Small secreted protein
G4D59_RS13630	COG0281	malic enzyme
G4D59_RS13635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4D59_RS13640	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G4D59_RS13650	COG0510	thiamine kinase activity
G4D59_RS13655	COG1597	lipid kinase activity
G4D59_RS13665	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
G4D59_RS13670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4D59_RS13675	COG3340	Belongs to the peptidase S51 family
G4D59_RS13680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4D59_RS13685	COG2252	PERMEase
G4D59_RS13690	COG1349	DNA-binding transcription factor activity
G4D59_RS13695	COG1187	pseudouridine synthase activity
G4D59_RS13700	COG2244	polysaccharide biosynthetic process
G4D59_RS13705	COG2081	HI0933 family
G4D59_RS13715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G4D59_RS13720	COG3196	Protein conserved in bacteria
G4D59_RS13730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4D59_RS13735	COG5578	integral membrane protein
G4D59_RS13740	COG0673	inositol 2-dehydrogenase activity
G4D59_RS13745	COG1653	transport
G4D59_RS13750	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
G4D59_RS13755	COG4209	transmembrane transport
G4D59_RS13760	COG2207	Transcriptional regulator
G4D59_RS13765	COG1733	regulation of RNA biosynthetic process
G4D59_RS13770	COG2814	Major facilitator Superfamily
G4D59_RS13775	COG0656	L-ascorbic acid biosynthetic process
G4D59_RS13780	COG1653	transport
G4D59_RS13785	COG0395	ABC-type sugar transport system, permease component
G4D59_RS13790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4D59_RS13795	COG1073	alpha beta
G4D59_RS13800	COG0495	leucyl-tRNA aminoacylation
G4D59_RS13810	COG2202	Pas domain
G4D59_RS13810	COG1366	Belongs to the anti-sigma-factor antagonist family
G4D59_RS13815	COG2433	Pfam Transposase IS66
G4D59_RS13820	COG0577	efflux transmembrane transporter activity
G4D59_RS13825	COG1136	(ABC) transporter
G4D59_RS13835	COG1131	(ABC) transporter
G4D59_RS13840	COG1725	Transcriptional regulator
G4D59_RS13860	COG1242	4 iron, 4 sulfur cluster binding
G4D59_RS13865	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
G4D59_RS13870	COG4326	sporulation control protein
G4D59_RS13880	COG2267	carboxylic ester hydrolase activity
G4D59_RS13885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G4D59_RS13890	COG0367	asparagine synthase
G4D59_RS13895	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G4D59_RS13900	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
G4D59_RS13910	COG1506	peptidase
G4D59_RS13915	COG1233	COG1233 Phytoene dehydrogenase and related
G4D59_RS13935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G4D59_RS13940	COG1116	anion transmembrane transporter activity
G4D59_RS13945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4D59_RS13950	COG0494	nUDIX hydrolase
G4D59_RS13955	COG2310	stress, protein
G4D59_RS13970	COG4824	toxin secretion phage lysis holin
G4D59_RS13980	COG0783	Belongs to the Dps family
G4D59_RS13995	COG1854	S-ribosylhomocysteine lyase activity
G4D59_RS14000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G4D59_RS14005	COG0288	reversible hydration of carbon dioxide
G4D59_RS14010	COG3443	Belongs to the bacterial solute-binding protein 9 family
G4D59_RS14010	COG0803	Belongs to the bacterial solute-binding protein 9 family
G4D59_RS14020	COG1271	oxidase subunit
G4D59_RS14025	COG1294	oxidase, subunit
G4D59_RS14040	COG4948	Mandelate Racemase Muconate Lactonizing
G4D59_RS14045	COG0318	PFAM AMP-dependent synthetase and ligase
G4D59_RS14050	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G4D59_RS14055	COG0596	Alpha beta hydrolase
G4D59_RS14060	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
G4D59_RS14065	COG1169	isochorismate synthase
G4D59_RS14070	COG1575	Belongs to the MenA family. Type 1 subfamily
G4D59_RS14075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G4D59_RS14205	COG3859	Proton-coupled thiamine transporter YuaJ
G4D59_RS14210	COG1247	-acetyltransferase
G4D59_RS14215	COG3339	Conserved Protein
G4D59_RS14220	COG0772	Belongs to the SEDS family
G4D59_RS14225	COG0772	Belongs to the SEDS family
G4D59_RS14230	COG2268	Band 7 protein
G4D59_RS14235	COG1585	Membrane protein implicated in regulation of membrane protease activity
G4D59_RS14240	COG2318	DinB family
G4D59_RS14245	COG1454	alcohol dehydrogenase
G4D59_RS14250	COG1012	belongs to the aldehyde dehydrogenase family
G4D59_RS14255	COG1510	regulation of RNA biosynthetic process
G4D59_RS14270	COG3409	Peptidoglycan-binding domain 1 protein
G4D59_RS14270	COG5632	N-Acetylmuramoyl-L-alanine amidase
G4D59_RS14325	COG3778	Protein conserved in bacteria
G4D59_RS14330	COG3299	homolog of phage Mu protein gp47
G4D59_RS14335	COG3628	GPW Gp25 family protein
G4D59_RS14345	COG4193	domain, Protein
G4D59_RS14350	COG1652	LysM domain
G4D59_RS14355	COG3953	SLT domain
G4D59_RS14355	COG5280	Phage tail tape measure protein TP901
G4D59_RS14355	COG3953	SLT domain
G4D59_RS14355	COG5280	Phage tail tape measure protein TP901
G4D59_RS14410	COG4653	Phage capsid family
G4D59_RS14415	COG0338	D12 class N6 adenine-specific DNA methyltransferase
G4D59_RS14420	COG5518	Phage portal protein
G4D59_RS14425	COG1783	phage Terminase large subunit
G4D59_RS14430	COG5484	DNA packaging
G4D59_RS14435	COG1595	DNA-templated transcription, initiation
G4D59_RS14445	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
G4D59_RS14465	COG1396	sequence-specific DNA binding
G4D59_RS14475	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G4D59_RS14490	COG0628	permease
G4D59_RS14500	COG0673	inositol 2-dehydrogenase activity
G4D59_RS14505	COG0693	protein deglycase activity
G4D59_RS14510	COG0840	transmembrane signaling receptor activity
G4D59_RS14515	COG0840	transmembrane signaling receptor activity
G4D59_RS14520	COG0840	transmembrane signaling receptor activity
G4D59_RS14525	COG0840	transmembrane signaling receptor activity
G4D59_RS14540	COG2070	2-Nitropropane dioxygenase
G4D59_RS14545	COG0432	Pfam Uncharacterised protein family UPF0047
G4D59_RS14550	COG1253	flavin adenine dinucleotide binding
G4D59_RS14555	COG2738	Putative neutral zinc metallopeptidase
G4D59_RS14565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4D59_RS14580	COG0166	Belongs to the GPI family
G4D59_RS14585	COG1979	alcohol dehydrogenase
G4D59_RS14590	COG1979	alcohol dehydrogenase
G4D59_RS14595	COG2155	Conserved Protein
G4D59_RS14600	COG1098	S1 RNA binding domain
G4D59_RS14605	COG0436	Aminotransferase
G4D59_RS14610	COG1522	sequence-specific DNA binding
G4D59_RS14615	COG2267	carboxylic ester hydrolase activity
G4D59_RS14625	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
G4D59_RS14630	COG2205	protein histidine kinase activity
G4D59_RS14645	COG5018	Exonuclease
G4D59_RS14650	COG2814	Major facilitator Superfamily
G4D59_RS14655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4D59_RS14660	COG3011	Protein conserved in bacteria
G4D59_RS14670	COG3290	protein histidine kinase activity
G4D59_RS14675	COG4565	transcriptional regulatory protein
G4D59_RS14680	COG1744	ABC transporter substrate-binding protein PnrA-like
G4D59_RS14685	COG3845	ABC transporter
G4D59_RS14690	COG4603	Belongs to the binding-protein-dependent transport system permease family
G4D59_RS14695	COG1079	Belongs to the binding-protein-dependent transport system permease family
G4D59_RS14700	COG3493	citrate carrier protein
G4D59_RS14710	COG2111	Na H antiporter
G4D59_RS14710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G4D59_RS14715	COG2111	Na H antiporter
G4D59_RS14720	COG1006	Multisubunit Na H antiporter MnhC subunit
G4D59_RS14725	COG0651	ATP synthesis coupled electron transport
G4D59_RS14730	COG1863	multisubunit Na H antiporter MnhE subunit
G4D59_RS14735	COG2212	antiporter activity
G4D59_RS14740	COG1320	monovalent cation:proton antiporter activity
G4D59_RS14745	COG2050	protein possibly involved in aromatic compounds catabolism
G4D59_RS14750	COG2197	response regulator
G4D59_RS14755	COG4585	Histidine kinase
G4D59_RS14765	COG0142	geranyltranstransferase activity
G4D59_RS14780	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
G4D59_RS14785	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G4D59_RS14790	COG1335	isochorismatase
G4D59_RS14795	COG5506	Protein of unknown function (DUF1694)
G4D59_RS14815	COG0628	permease
G4D59_RS14830	COG1418	mRNA catabolic process
G4D59_RS14835	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS14845	COG1511	domain protein
G4D59_RS14850	COG0433	COG0433 Predicted ATPase
G4D59_RS14850	COG1674	ftsk spoiiie
G4D59_RS14855	COG4499	WXG100 protein secretion system (Wss), protein YukC
G4D59_RS14860	COG5417	Belongs to the EsaB family
G4D59_RS14865	COG4842	Belongs to the WXG100 family
G4D59_RS14870	COG2508	Transcriptional regulator
G4D59_RS14870	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
G4D59_RS14875	COG0686	Belongs to the AlaDH PNT family
G4D59_RS14880	COG1268	BioY protein
G4D59_RS14885	COG2056	Na+-H+ antiporter family
G4D59_RS14890	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G4D59_RS14895	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
G4D59_RS14900	COG3584	3D domain protein
G4D59_RS14915	COG1252	NADH dehydrogenase
G4D59_RS14920	COG0492	ferredoxin-NADP+ reductase activity
G4D59_RS14935	COG0789	Transcriptional regulator
G4D59_RS14940	COG5504	Zn-dependent protease
G4D59_RS14945	COG0316	Belongs to the HesB IscA family
G4D59_RS14950	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G4D59_RS14955	COG4844	belongs to the
G4D59_RS14960	COG1252	NADH dehydrogenase
G4D59_RS14970	COG4837	Protein of unknown function (DUF1462)
G4D59_RS14980	COG4946	Tricorn protease homolog
G4D59_RS14980	COG1506	peptidase
G4D59_RS14980	COG0823	Involved in the tonB-independent uptake of proteins
G4D59_RS14985	COG0083	homoserine kinase activity
G4D59_RS14990	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G4D59_RS14995	COG0460	homoserine dehydrogenase
G4D59_RS15000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4D59_RS15005	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G4D59_RS15010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G4D59_RS15030	COG0647	UMP catabolic process
G4D59_RS15035	COG2445	Protein of unknown function DUF86
G4D59_RS15040	COG4470	Protein conserved in bacteria
G4D59_RS15050	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G4D59_RS15055	COG0739	heme binding
G4D59_RS15075	COG3377	Domain of unknown function (DUF1805)
G4D59_RS15080	COG0737	Belongs to the 5'-nucleotidase family
G4D59_RS15085	COG1801	Protein of unknown function DUF72
G4D59_RS15090	COG2508	Transcriptional regulator
G4D59_RS15095	COG2140	Oxalate decarboxylase
G4D59_RS15100	COG2814	Major facilitator Superfamily
G4D59_RS15105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
G4D59_RS15110	COG2356	endonuclease I
G4D59_RS15120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4D59_RS15125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4D59_RS15130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4D59_RS15150	COG5002	protein histidine kinase activity
G4D59_RS15150	COG0642	Histidine kinase
G4D59_RS15155	COG0745	RESPONSE REGULATOR receiver
G4D59_RS15160	COG2311	Membrane
G4D59_RS15170	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G4D59_RS15180	COG1309	transcriptional regulator
G4D59_RS15190	COG0719	Fe-S assembly protein
G4D59_RS15195	COG0822	iron-sulfur transferase activity
G4D59_RS15200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4D59_RS15205	COG0719	Fe-S assembly protein
G4D59_RS15210	COG0396	ATPase activity
G4D59_RS15220	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4D59_RS15225	COG1464	Belongs to the NlpA lipoprotein family
G4D59_RS15230	COG2011	ABC-type metal ion transport system permease component
G4D59_RS15235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G4D59_RS15245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4D59_RS15250	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
G4D59_RS15260	COG0509	glycine decarboxylation via glycine cleavage system
G4D59_RS15265	COG1393	Belongs to the ArsC family
G4D59_RS15270	COG1960	acyl-CoA dehydrogenase activity
G4D59_RS15275	COG0183	Belongs to the thiolase family
G4D59_RS15280	COG1024	Enoyl-CoA hydratase
G4D59_RS15280	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4D59_RS15295	COG5577	PFAM Coat F domain
G4D59_RS15305	COG1120	ATPase activity
G4D59_RS15315	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS15320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4D59_RS15325	COG0745	RESPONSE REGULATOR receiver
G4D59_RS15330	COG2205	protein histidine kinase activity
G4D59_RS15330	COG2770	Histidine kinase
G4D59_RS15340	COG1309	transcriptional regulator
G4D59_RS15345	COG0114	fumarate hydratase activity
G4D59_RS15355	COG0697	spore germination
G4D59_RS15360	COG0814	amino acid
G4D59_RS15375	COG2197	response regulator
G4D59_RS15380	COG4585	Histidine kinase
G4D59_RS15385	COG4758	membrane
G4D59_RS15395	COG1842	Phage shock protein A
G4D59_RS15400	COG4758	membrane
G4D59_RS15405	COG2096	Adenosyltransferase
G4D59_RS15410	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS15415	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G4D59_RS15440	COG1454	alcohol dehydrogenase
G4D59_RS15445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4D59_RS15450	COG1120	ATPase activity
G4D59_RS15455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4D59_RS15460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4D59_RS15470	COG2721	sulfolactate sulfo-lyase activity
G4D59_RS15475	COG0246	Mannitol dehydrogenase
G4D59_RS15480	COG1609	Transcriptional regulator
G4D59_RS15485	COG1904	glucuronate isomerase
G4D59_RS15490	COG2205	protein histidine kinase activity
G4D59_RS15495	COG0745	RESPONSE REGULATOR receiver
G4D59_RS15500	COG1120	ATPase activity
G4D59_RS15505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4D59_RS15510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4D59_RS15515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4D59_RS15520	COG0531	amino acid
G4D59_RS15535	COG1988	membrane-bound metal-dependent
G4D59_RS15540	COG1368	sulfuric ester hydrolase activity
G4D59_RS15545	COG0725	ABC transporter, periplasmic molybdate-binding protein
G4D59_RS15550	COG4149	molybdate abc transporter
G4D59_RS15555	COG0656	L-ascorbic acid biosynthetic process
G4D59_RS15560	COG1940	carbohydrate kinase activity
G4D59_RS15565	COG0025	NhaP-type Na H and K H
G4D59_RS15570	COG2860	membrane
G4D59_RS15575	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G4D59_RS15580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4D59_RS15585	COG2217	Heavy metal translocating P-type atpase
G4D59_RS15590	COG1121	(ABC) transporter
G4D59_RS15595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4D59_RS15600	COG0803	Belongs to the bacterial solute-binding protein 9 family
G4D59_RS15610	COG3226	Transcriptional regulator
G4D59_RS15615	COG0784	Response regulator, receiver
G4D59_RS15620	COG4191	Histidine kinase
G4D59_RS15625	COG1027	Aspartate ammonia-lyase
G4D59_RS15640	COG2217	Heavy metal translocating P-type atpase
G4D59_RS15645	COG2608	mercury ion transmembrane transporter activity
G4D59_RS15650	COG1937	Protein conserved in bacteria
G4D59_RS15685	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G4D59_RS15690	COG0557	exoribonuclease II activity
G4D59_RS15695	COG1647	Serine aminopeptidase, S33
G4D59_RS15700	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G4D59_RS15705	COG2002	toxin-antitoxin pair type II binding
G4D59_RS15710	COG1476	TRANSCRIPTIONal
G4D59_RS15715	COG1396	sequence-specific DNA binding
G4D59_RS15720	COG1396	sequence-specific DNA binding
G4D59_RS15725	COG1733	regulation of RNA biosynthetic process
G4D59_RS15730	COG1174	glycine betaine transport
G4D59_RS15735	COG1732	Glycine betaine
G4D59_RS15740	COG1174	glycine betaine transport
G4D59_RS15745	COG0517	IMP dehydrogenase activity
G4D59_RS15745	COG1125	glycine betaine transport
G4D59_RS15750	COG1510	regulation of RNA biosynthetic process
G4D59_RS15755	COG2095	MarC family integral membrane protein
G4D59_RS15765	COG0456	acetyltransferase
G4D59_RS15785	COG1131	(ABC) transporter
G4D59_RS15795	COG0148	phosphopyruvate hydratase activity
G4D59_RS15800	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
G4D59_RS15805	COG0149	triose-phosphate isomerase activity
G4D59_RS15810	COG0126	phosphoglycerate kinase activity
G4D59_RS15815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4D59_RS15820	COG2390	Transcriptional regulator
G4D59_RS15825	COG0833	amino acid
G4D59_RS15830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4D59_RS15835	COG3829	transcription factor binding
G4D59_RS15840	COG2186	Transcriptional regulator
G4D59_RS15845	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G4D59_RS15855	COG0534	Mate efflux family protein
G4D59_RS15860	COG4608	Belongs to the ABC transporter superfamily
G4D59_RS15865	COG0444	Belongs to the ABC transporter superfamily
G4D59_RS15870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4D59_RS15875	COG0601	transmembrane transport
G4D59_RS15880	COG0747	negative chemotaxis
G4D59_RS15885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G4D59_RS15890	COG0110	maltose O-acetyltransferase activity
G4D59_RS15895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G4D59_RS15900	COG2244	polysaccharide biosynthetic process
G4D59_RS15905	COG5039	Polysaccharide pyruvyl transferase
G4D59_RS15910	COG1216	Glycosyl transferase, family 2
G4D59_RS15920	COG0438	transferase activity, transferring glycosyl groups
G4D59_RS15925	COG1215	transferase activity, transferring glycosyl groups
G4D59_RS15930	COG0438	transferase activity, transferring glycosyl groups
G4D59_RS15935	COG1086	Polysaccharide biosynthesis protein
G4D59_RS15940	COG0489	protein tyrosine kinase activity
G4D59_RS15945	COG3944	biosynthesis protein
G4D59_RS15950	COG1396	sequence-specific DNA binding
G4D59_RS15960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4D59_RS15965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4D59_RS15970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4D59_RS15975	COG0726	polysaccharide deacetylase
G4D59_RS15980	COG0488	(ABC) transporter
G4D59_RS15985	COG4608	Belongs to the ABC transporter superfamily
G4D59_RS16000	COG0601	transmembrane transport
G4D59_RS16005	COG0747	negative chemotaxis
G4D59_RS16010	COG1819	glycosyl
G4D59_RS16025	COG0740	serine-type endopeptidase activity
G4D59_RS16030	COG1611	Belongs to the LOG family
G4D59_RS16035	COG1694	Mazg nucleotide pyrophosphohydrolase
G4D59_RS16040	COG0659	secondary active sulfate transmembrane transporter activity
G4D59_RS16045	COG0288	reversible hydration of carbon dioxide
G4D59_RS16050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4D59_RS16065	COG2162	N-hydroxyarylamine O-acetyltransferase activity
G4D59_RS16070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4D59_RS16075	COG1481	regulation of sporulation
G4D59_RS16080	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G4D59_RS16085	COG1660	Displays ATPase and GTPase activities
G4D59_RS16090	COG1051	belongs to the nudix hydrolase family
G4D59_RS16095	COG0492	ferredoxin-NADP+ reductase activity
G4D59_RS16100	COG0791	NLP P60 protein
G4D59_RS16100	COG3883	PFAM NLP P60 protein
G4D59_RS16105	COG0457	Tetratricopeptide repeat
G4D59_RS16110	COG0140	phosphoribosyl-ATP diphosphatase activity
G4D59_RS16110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G4D59_RS16115	COG0107	imidazoleglycerol-phosphate synthase activity
G4D59_RS16120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G4D59_RS16125	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G4D59_RS16130	COG0131	Imidazoleglycerol-phosphate dehydratase
G4D59_RS16135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G4D59_RS16140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G4D59_RS16145	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G4D59_RS16150	COG4990	cell redox homeostasis
G4D59_RS16160	COG2910	NAD(P)H-binding
G4D59_RS16165	COG1959	2 iron, 2 sulfur cluster binding
G4D59_RS16170	COG0110	maltose O-acetyltransferase activity
G4D59_RS16175	COG0546	phosphoglycolate phosphatase activity
G4D59_RS16180	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
G4D59_RS16190	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G4D59_RS16195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G4D59_RS16200	COG0363	glucosamine-6-phosphate deaminase activity
G4D59_RS16205	COG2188	Transcriptional regulator
G4D59_RS16210	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G4D59_RS16215	COG1950	PFAM Membrane protein of
G4D59_RS16220	COG1983	PspC domain protein
G4D59_RS16225	COG3595	metallopeptidase activity
G4D59_RS16240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G4D59_RS16250	COG4897	Protein conserved in bacteria
G4D59_RS16255	COG3848	Pyruvate phosphate dikinase
G4D59_RS16255	COG0574	Belongs to the PEP-utilizing enzyme family
G4D59_RS16260	COG1309	transcriptional regulator
G4D59_RS16265	COG2814	Major facilitator Superfamily
G4D59_RS16275	COG0745	RESPONSE REGULATOR receiver
G4D59_RS16280	COG5002	protein histidine kinase activity
G4D59_RS16285	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G4D59_RS16290	COG0463	Glycosyl transferase, family 2
G4D59_RS16295	COG1113	amino acid transport
G4D59_RS16300	COG0778	Nitroreductase
G4D59_RS16305	COG1733	regulation of RNA biosynthetic process
G4D59_RS16310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4D59_RS16320	COG3409	Peptidoglycan-binding domain 1 protein
G4D59_RS16320	COG0793	Belongs to the peptidase S41A family
G4D59_RS16325	COG0730	response to heat
G4D59_RS16330	COG3883	PFAM NLP P60 protein
G4D59_RS16330	COG0791	NLP P60 protein
G4D59_RS16335	COG2177	Part of the ABC transporter FtsEX involved in
G4D59_RS16340	COG2884	Cell division ATP-binding protein ftsE
G4D59_RS16345	COG2010	Cytochrome c
G4D59_RS16350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4D59_RS16370	COG0653	protein targeting
G4D59_RS16375	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G4D59_RS16380	COG0840	transmembrane signaling receptor activity
G4D59_RS16395	COG1516	flagellar protein fliS
G4D59_RS16400	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
G4D59_RS16405	COG1334	flagellar protein FlaG
G4D59_RS16410	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
G4D59_RS16415	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
G4D59_RS16425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G4D59_RS16430	COG1256	bacterial-type flagellum assembly
G4D59_RS16430	COG4786	Flagellar basal body rod
G4D59_RS16435	COG3418	PFAM FlgN family protein
G4D59_RS16450	COG1040	competence protein
G4D59_RS16460	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
G4D59_RS16465	COG1307	EDD domain protein, DegV family
G4D59_RS16470	COG2197	response regulator
G4D59_RS16475	COG4585	Histidine kinase
G4D59_RS16480	COG1739	Uncharacterized protein family UPF0029
G4D59_RS16485	COG1316	TRANSCRIPTIONal
G4D59_RS16490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G4D59_RS16495	COG0438	transferase activity, transferring glycosyl groups
G4D59_RS16500	COG1215	transferase activity, transferring glycosyl groups
G4D59_RS16505	COG3206	protein involved in exopolysaccharide biosynthesis
G4D59_RS16510	COG3307	-O-antigen
G4D59_RS16515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4D59_RS16520	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G4D59_RS16525	COG0297	glycogen (starch) synthase activity
G4D59_RS16525	COG0438	transferase activity, transferring glycosyl groups
G4D59_RS16530	COG2244	polysaccharide biosynthetic process
G4D59_RS16545	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4D59_RS16545	COG2247	cell wall binding repeat
G4D59_RS16550	COG2247	cell wall binding repeat
G4D59_RS16550	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4D59_RS16555	COG2247	cell wall binding repeat
G4D59_RS16555	COG2385	sporulation resulting in formation of a cellular spore
G4D59_RS16565	COG1316	TRANSCRIPTIONal
G4D59_RS16570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G4D59_RS16575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G4D59_RS16580	COG1134	teichoic acid transport
G4D59_RS16585	COG1682	transport, permease protein
G4D59_RS16590	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
G4D59_RS16590	COG0463	Glycosyl transferase, family 2
G4D59_RS16595	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
G4D59_RS16605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G4D59_RS16610	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
G4D59_RS16615	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
G4D59_RS16620	COG4193	domain, Protein
G4D59_RS16625	COG1482	cell wall glycoprotein biosynthetic process
G4D59_RS16635	COG1175	transmembrane transport
G4D59_RS16640	COG1653	transport
G4D59_RS16645	COG2197	response regulator
G4D59_RS16650	COG2972	Histidine kinase
G4D59_RS16660	COG0454	-acetyltransferase
G4D59_RS16665	COG0800	Aldolase
G4D59_RS16670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4D59_RS16675	COG1609	Transcriptional regulator
G4D59_RS16680	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
G4D59_RS16685	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS16690	COG0697	spore germination
G4D59_RS16695	COG0814	amino acid
G4D59_RS16710	COG2814	Major facilitator Superfamily
G4D59_RS16715	COG1316	TRANSCRIPTIONal
G4D59_RS16720	COG0561	phosphatase activity
G4D59_RS16725	COG0791	NLP P60 protein
G4D59_RS16735	COG2843	Capsule synthesis protein
G4D59_RS16745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G4D59_RS16750	COG0697	spore germination
G4D59_RS16765	COG1609	Transcriptional regulator
G4D59_RS16770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4D59_RS16775	COG1869	D-ribose catabolic process
G4D59_RS16780	COG1129	ABC transporter
G4D59_RS16785	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4D59_RS16790	COG1879	ABC-type sugar transport system periplasmic component
G4D59_RS16795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G4D59_RS16800	COG0583	DNA-binding transcription factor activity
G4D59_RS16805	COG0028	Belongs to the TPP enzyme family
G4D59_RS16810	COG3527	Alpha-acetolactate decarboxylase
G4D59_RS16815	COG1522	sequence-specific DNA binding
G4D59_RS16820	COG2059	Chromate
G4D59_RS16825	COG2059	Chromate
G4D59_RS16830	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G4D59_RS16840	COG4715	Zinc finger, swim domain protein
G4D59_RS16845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G4D59_RS16850	COG1366	Belongs to the anti-sigma-factor antagonist family
G4D59_RS16850	COG2202	Pas domain
G4D59_RS16855	COG0561	phosphatase activity
G4D59_RS16870	COG1970	mechanosensitive ion channel activity
G4D59_RS16875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G4D59_RS16880	COG0457	Tetratricopeptide repeat
G4D59_RS16885	COG4786	Flagellar basal body rod
G4D59_RS16890	COG4786	Flagellar basal body rod
G4D59_RS16895	COG1077	Cell shape determining protein MreB Mrl
G4D59_RS16900	COG1609	Transcriptional regulator
G4D59_RS16905	COG1846	Transcriptional regulator
G4D59_RS16910	COG2814	Major facilitator Superfamily
G4D59_RS16915	COG0671	phosphoesterase, PA-phosphatase related
G4D59_RS16920	COG0477	Major facilitator Superfamily
G4D59_RS16925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4D59_RS16930	COG0765	amino acid transport
G4D59_RS16935	COG1126	abc transporter atp-binding protein
G4D59_RS16940	COG0004	ammonium transporteR
G4D59_RS16945	COG0347	Belongs to the P(II) protein family
G4D59_RS16950	COG0739	heme binding
G4D59_RS16955	COG1247	-acetyltransferase
G4D59_RS16990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G4D59_RS16995	COG0523	cobalamin synthesis protein
G4D59_RS17000	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G4D59_RS17005	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G4D59_RS17010	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G4D59_RS17015	COG2223	nitrite transmembrane transporter activity
G4D59_RS17025	COG2304	oxidoreductase activity
G4D59_RS17030	COG2304	oxidoreductase activity
G4D59_RS17035	COG2385	sporulation resulting in formation of a cellular spore
G4D59_RS17040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G4D59_RS17050	COG4836	Membrane
G4D59_RS17060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G4D59_RS17065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G4D59_RS17070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G4D59_RS17075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G4D59_RS17080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G4D59_RS17085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G4D59_RS17090	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G4D59_RS17095	COG0356	it plays a direct role in the translocation of protons across the membrane
G4D59_RS17105	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G4D59_RS17110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G4D59_RS17115	COG4475	Protein of unknown function (DUF436)
G4D59_RS17120	COG0698	ribose 5-phosphate isomerase
G4D59_RS17125	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4D59_RS17130	COG1971	Probably functions as a manganese efflux pump
G4D59_RS17135	COG0009	L-threonylcarbamoyladenylate synthase
G4D59_RS17140	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G4D59_RS17155	COG2890	protein-(glutamine-N5) methyltransferase activity
G4D59_RS17160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G4D59_RS17165	COG0789	Transcriptional regulator
G4D59_RS17170	COG0679	Auxin Efflux Carrier
G4D59_RS17175	COG0281	malic enzyme
G4D59_RS17180	COG1435	thymidine kinase activity
G4D59_RS17185	COG0254	rRNA binding
G4D59_RS17190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G4D59_RS17195	COG1494	fructose-1,6-bisphosphatase
G4D59_RS17200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G4D59_RS17205	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4D59_RS17210	COG0191	fructose-bisphosphate aldolase activity
G4D59_RS17215	COG2204	response regulator
G4D59_RS17220	COG4821	SIS domain
G4D59_RS17225	COG0504	CTP synthase activity
G4D59_RS17230	COG3343	RNA polymerase activity
G4D59_RS17245	COG1960	acyl-CoA dehydrogenase activity
G4D59_RS17250	COG1960	acyl-CoA dehydrogenase activity
G4D59_RS17255	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4D59_RS17260	COG0183	Belongs to the thiolase family
G4D59_RS17265	COG0247	lactate metabolic process
G4D59_RS17265	COG2181	nitrate reductase activity
G4D59_RS17270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4D59_RS17275	COG4294	response to UV
G4D59_RS17285	COG1619	proteins homologs of microcin C7 resistance protein MccF
G4D59_RS17295	COG1132	(ABC) transporter
G4D59_RS17300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4D59_RS17305	COG1619	proteins homologs of microcin C7 resistance protein MccF
G4D59_RS17310	COG0018	arginyl-trna synthetase
G4D59_RS17315	COG4506	Protein conserved in bacteria
G4D59_RS17325	COG0010	Belongs to the arginase family
G4D59_RS17330	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G4D59_RS17335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4D59_RS17345	COG1994	Peptidase M50
G4D59_RS17350	COG1942	4-Oxalocrotonate Tautomerase
G4D59_RS17360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4D59_RS17365	COG0583	DNA-binding transcription factor activity
G4D59_RS17370	COG0431	NADPH-dependent FMN reductase
G4D59_RS17375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4D59_RS17380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G4D59_RS17385	COG0454	-acetyltransferase
G4D59_RS17390	COG0765	amino acid transport
G4D59_RS17400	COG0765	amino acid transport
G4D59_RS17405	COG1126	abc transporter atp-binding protein
G4D59_RS17410	COG3465	dGTPase activity
G4D59_RS17415	COG1078	dGTPase activity
G4D59_RS17420	COG4844	belongs to the
G4D59_RS17470	COG5444	nuclease activity
G4D59_RS17500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G4D59_RS17510	COG0280	phosphate acetyltransferase
G4D59_RS17520	COG2814	Major facilitator Superfamily
G4D59_RS17525	COG1522	sequence-specific DNA binding
G4D59_RS17530	COG2814	Major facilitator Superfamily
G4D59_RS17535	COG0077	Prephenate dehydratase
G4D59_RS17540	COG1917	Cupin 2, conserved barrel domain protein
G4D59_RS17545	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS17550	COG0151	Belongs to the GarS family
G4D59_RS17555	COG0436	Aminotransferase
G4D59_RS17560	COG1028	Short-chain dehydrogenase reductase Sdr
G4D59_RS17565	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
G4D59_RS17570	COG1091	dTDP-4-dehydrorhamnose reductase activity
G4D59_RS17575	COG1088	dTDP-glucose 4,6-dehydratase activity
G4D59_RS17580	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G4D59_RS17585	COG3980	spore coat polysaccharide biosynthesis protein
G4D59_RS17590	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
G4D59_RS17595	COG2089	acid synthase
G4D59_RS17600	COG0456	acetyltransferase
G4D59_RS17605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G4D59_RS17610	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
G4D59_RS17615	COG0463	Glycosyl transferase, family 2
G4D59_RS17635	COG2363	Small membrane protein
G4D59_RS17640	COG2233	PERMEase
G4D59_RS17650	COG1012	belongs to the aldehyde dehydrogenase family
G4D59_RS17655	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G4D59_RS17660	COG1216	Glycosyl transferase, family 2
G4D59_RS17670	COG0351	phosphomethylpyrimidine kinase
G4D59_RS17685	COG1621	beta-fructofuranosidase activity
G4D59_RS17690	COG1263	PTS System
G4D59_RS17690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4D59_RS17695	COG3711	transcriptional antiterminator
G4D59_RS17705	COG1404	Belongs to the peptidase S8 family
G4D59_RS17715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4D59_RS17720	COG0778	Nitroreductase
G4D59_RS17725	COG0772	Belongs to the SEDS family
G4D59_RS17735	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G4D59_RS17740	COG1845	cytochrome c oxidase, subunit III
G4D59_RS17745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G4D59_RS17750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G4D59_RS17760	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
G4D59_RS17765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G4D59_RS17770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
G4D59_RS17785	COG2246	polysaccharide biosynthetic process
G4D59_RS17810	COG0457	Tetratricopeptide repeat
G4D59_RS17825	COG3162	membrane
G4D59_RS17830	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4D59_RS17845	COG0352	thiamine-phosphate diphosphorylase activity
G4D59_RS17850	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
G4D59_RS17855	COG0583	DNA-binding transcription factor activity
G4D59_RS17860	COG1380	Effector of murein hydrolase LrgA
G4D59_RS17865	COG1346	cytolysis
G4D59_RS17870	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G4D59_RS17875	COG0346	lactoylglutathione lyase activity
G4D59_RS17885	COG0765	amino acid transport
G4D59_RS17890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4D59_RS17895	COG0457	Tetratricopeptide repeat
G4D59_RS17905	COG2357	RelA SpoT domain protein
G4D59_RS17910	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4D59_RS17915	COG1129	ABC transporter
G4D59_RS17925	COG3420	alginic acid biosynthetic process
G4D59_RS17930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4D59_RS17940	COG1486	melibiose metabolic process
G4D59_RS17945	COG1447	Phosphotransferase system cellobiose-specific component IIA
G4D59_RS17950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4D59_RS17955	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4D59_RS17960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4D59_RS17960	COG3711	transcriptional antiterminator
G4D59_RS17975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G4D59_RS17990	COG1595	DNA-templated transcription, initiation
G4D59_RS18000	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G4D59_RS18005	COG4988	ABC transporter
G4D59_RS18010	COG1294	oxidase, subunit
G4D59_RS18015	COG1271	oxidase subunit
G4D59_RS18025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4D59_RS18030	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
G4D59_RS18035	COG4509	Sortase family
G4D59_RS18060	COG5386	Cell surface protein
G4D59_RS18065	COG5386	Cell surface protein
G4D59_RS18070	COG1733	regulation of RNA biosynthetic process
G4D59_RS18075	COG2514	catechol 2,3-dioxygenase activity
G4D59_RS18080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4D59_RS18080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4D59_RS18085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4D59_RS18085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4D59_RS18095	COG0726	polysaccharide deacetylase
G4D59_RS18100	COG1447	Phosphotransferase system cellobiose-specific component IIA
G4D59_RS18105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4D59_RS18110	COG2723	6-phospho-beta-galactosidase activity
G4D59_RS18120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4D59_RS18125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4D59_RS18125	COG3711	transcriptional antiterminator
G4D59_RS18150	COG1757	Na H antiporter
G4D59_RS18155	COG1027	Aspartate ammonia-lyase
G4D59_RS18160	COG0252	asparaginase activity
G4D59_RS18165	COG1396	sequence-specific DNA binding
G4D59_RS18190	COG4842	Belongs to the WXG100 family
G4D59_RS18195	COG2195	Cleaves the N-terminal amino acid of tripeptides
G4D59_RS18210	COG1737	Transcriptional regulator
G4D59_RS18215	COG2084	Dehydrogenase
G4D59_RS18225	COG2610	gluconate transmembrane transporter activity
G4D59_RS18230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G4D59_RS18235	COG2850	peptidyl-arginine hydroxylation
G4D59_RS18255	COG2723	6-phospho-beta-galactosidase activity
G4D59_RS18260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4D59_RS18260	COG2190	(PTS) system
G4D59_RS18260	COG1263	PTS System
G4D59_RS18265	COG3711	transcriptional antiterminator
G4D59_RS18270	COG3878	Protein conserved in bacteria
G4D59_RS18280	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G4D59_RS18285	COG1122	ATPase activity
G4D59_RS18290	COG4721	ABC-type cobalt transport system, permease component
G4D59_RS18295	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G4D59_RS18330	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
G4D59_RS18335	COG0778	Nitroreductase
G4D59_RS18340	COG1846	Transcriptional regulator
G4D59_RS18345	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
G4D59_RS18350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G4D59_RS18355	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
G4D59_RS18360	COG2390	Transcriptional regulator
G4D59_RS18370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G4D59_RS18370	COG2755	lipolytic protein G-D-S-L family
G4D59_RS18375	COG0477	Major facilitator Superfamily
G4D59_RS18380	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G4D59_RS18385	COG2226	methyltransferase
G4D59_RS18395	COG0561	phosphatase activity
G4D59_RS18400	COG0789	Transcriptional regulator
G4D59_RS18405	COG0673	inositol 2-dehydrogenase activity
G4D59_RS18410	COG0840	transmembrane signaling receptor activity
G4D59_RS18415	COG1113	amino acid transport
G4D59_RS18420	COG4335	DNA alkylation repair
G4D59_RS18430	COG1070	Carbohydrate kinase
G4D59_RS18435	COG1737	Transcriptional regulator
G4D59_RS18475	COG0583	DNA-binding transcription factor activity
G4D59_RS18480	COG1609	Transcriptional regulator
G4D59_RS18485	COG2182	Extracellular solute-binding protein
G4D59_RS18490	COG1175	transmembrane transport
G4D59_RS18495	COG3833	ABC-type maltose transport systems, permease component
G4D59_RS18505	COG1874	Beta-galactosidase
G4D59_RS18510	COG2851	Citrate transporter
G4D59_RS18520	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
G4D59_RS18525	COG1131	(ABC) transporter
G4D59_RS18530	COG2824	Alkylphosphonate utilization operon protein PhnA
G4D59_RS18535	COG1929	Belongs to the glycerate kinase type-1 family
G4D59_RS18540	COG2610	gluconate transmembrane transporter activity
G4D59_RS18545	COG3835	regulator
G4D59_RS18550	COG1309	transcriptional regulator
G4D59_RS18565	COG1136	(ABC) transporter
G4D59_RS18570	COG0457	Tetratricopeptide repeat
G4D59_RS18575	COG3711	transcriptional antiterminator
G4D59_RS18580	COG2723	6-phospho-beta-galactosidase activity
G4D59_RS18585	COG1263	PTS System
G4D59_RS18585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4D59_RS18585	COG2190	(PTS) system
G4D59_RS18610	COG0494	nUDIX hydrolase
G4D59_RS18625	COG1113	amino acid transport
G4D59_RS18630	COG1609	Transcriptional regulator
G4D59_RS18635	COG2814	Major facilitator Superfamily
G4D59_RS18640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G4D59_RS18645	COG2814	Major facilitator Superfamily
G4D59_RS18670	COG5444	nuclease activity
G4D59_RS18690	COG2723	6-phospho-beta-galactosidase activity
G4D59_RS18700	COG2188	Transcriptional regulator
G4D59_RS18715	COG0384	phenazine biosynthesis protein PhzF
G4D59_RS18720	COG0583	DNA-binding transcription factor activity
G4D59_RS18740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4D59_RS18745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4D59_RS18770	COG0210	DNA helicase
G4D59_RS18775	COG0210	DNA helicase
G4D59_RS18785	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G4D59_RS18795	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G4D59_RS18805	COG4720	Psort location CytoplasmicMembrane, score
G4D59_RS18825	COG0456	acetyltransferase
G4D59_RS18830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4D59_RS18835	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G4D59_RS18840	COG4853	Protein conserved in bacteria
G4D59_RS18845	COG4863	YycH protein
G4D59_RS18850	COG5002	protein histidine kinase activity
G4D59_RS18855	COG0745	RESPONSE REGULATOR receiver
G4D59_RS18880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G4D59_RS18890	COG2311	Membrane
G4D59_RS18895	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G4D59_RS18900	COG1309	transcriptional regulator
G4D59_RS18905	COG2124	cytochrome p450
G4D59_RS18910	COG0346	lactoylglutathione lyase activity
G4D59_RS18915	COG0305	Participates in initiation and elongation during chromosome replication
G4D59_RS18930	COG2819	hydrolase of the alpha beta superfamily
G4D59_RS18935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4D59_RS18935	COG2207	Transcriptional regulator
G4D59_RS18940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4D59_RS18945	COG2819	hydrolase of the alpha beta superfamily
G4D59_RS18950	COG3093	addiction module antidote protein HigA
G4D59_RS18955	COG2807	transmembrane transport
G4D59_RS18960	COG0359	binds to the 23S rRNA
G4D59_RS18965	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
G4D59_RS18970	COG4241	membrane
G4D59_RS18975	COG1227	inorganic diphosphatase activity
G4D59_RS18985	COG1595	DNA-templated transcription, initiation
G4D59_RS18995	COG0753	catalase activity
G4D59_RS19000	COG0655	NAD(P)H dehydrogenase (quinone) activity
G4D59_RS19005	COG0400	carboxylic ester hydrolase activity
G4D59_RS19010	COG0346	lactoylglutathione lyase activity
G4D59_RS19015	COG1174	glycine betaine transport
G4D59_RS19020	COG0517	IMP dehydrogenase activity
G4D59_RS19020	COG1125	glycine betaine transport
G4D59_RS19025	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G4D59_RS19030	COG0629	single-stranded DNA binding
G4D59_RS19035	COG0360	Binds together with S18 to 16S ribosomal RNA
G4D59_RS19040	COG0012	GTP binding
G4D59_RS19045	COG4481	Protein conserved in bacteria
G4D59_RS19060	COG3949	Membrane
G4D59_RS19070	COG1475	DNA binding
G4D59_RS19075	COG1192	Involved in chromosome partitioning
G4D59_RS19085	COG1475	DNA binding
G4D59_RS19090	COG0357	Ribosomal RNA small subunit methyltransferase G
G4D59_RS19095	COG0445	tRNA wobble uridine modification
G4D59_RS19100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G4D59_RS19105	COG1847	R3H domain protein
G4D59_RS19110	COG0706	membrane insertase activity
G4D59_RS19115	COG0594	ribonuclease P activity
G4D59_RS19120	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G4D59_RS19125	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G4D59_RS19130	COG0592	DNA-directed DNA polymerase activity
G4D59_RS19135	COG2501	S4 domain
G4D59_RS19140	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G4D59_RS19150	COG0187	DNA topoisomerase II activity
G4D59_RS19155	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G4D59_RS19190	COG0516	GMP reductase activity
G4D59_RS19190	COG0517	IMP dehydrogenase activity
G4D59_RS19195	COG1686	Belongs to the peptidase S11 family
G4D59_RS19200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4D59_RS19205	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
G4D59_RS19210	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
G4D59_RS19215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G4D59_RS19230	COG1428	Deoxynucleoside kinase
G4D59_RS19235	COG1428	Deoxynucleoside kinase
G4D59_RS19240	COG1388	LysM domain
G4D59_RS19240	COG3858	chitin binding
G4D59_RS19245	COG1335	isochorismatase
G4D59_RS19250	COG0590	tRNA wobble adenosine to inosine editing
G4D59_RS19260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G4D59_RS19265	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G4D59_RS19270	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G4D59_RS19305	COG1331	Highly conserved protein containing a thioredoxin domain
G4D59_RS19370	COG1312	Catalyzes the dehydration of D-mannonate