locus-tag	class	description
HTY60_RS00010	COG0592	DNA-directed DNA polymerase activity
HTY60_RS00015	COG2501	S4 domain
HTY60_RS00030	COG0187	DNA topoisomerase II activity
HTY60_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HTY60_RS00070	COG0517	IMP dehydrogenase activity
HTY60_RS00070	COG0516	GMP reductase activity
HTY60_RS00075	COG1686	Belongs to the peptidase S11 family
HTY60_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
HTY60_RS00105	COG1428	Deoxynucleoside kinase
HTY60_RS00110	COG1428	Deoxynucleoside kinase
HTY60_RS00115	COG1388	LysM domain
HTY60_RS00115	COG3858	chitin binding
HTY60_RS00120	COG1335	isochorismatase
HTY60_RS00125	COG0590	tRNA wobble adenosine to inosine editing
HTY60_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HTY60_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HTY60_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HTY60_RS00195	COG3853	Toxic anion resistance protein (TelA)
HTY60_RS00200	COG1982	Orn Lys Arg decarboxylase major
HTY60_RS00210	COG3870	Protein conserved in bacteria
HTY60_RS00215	COG1728	Protein conserved in bacteria
HTY60_RS00220	COG0470	DNA polymerase III
HTY60_RS00225	COG1774	PSP1 C-terminal conserved region
HTY60_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HTY60_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HTY60_RS00250	COG2002	toxin-antitoxin pair type II binding
HTY60_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HTY60_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HTY60_RS00260	COG0084	hydrolase, TatD family'
HTY60_RS00265	COG3583	domain protein
HTY60_RS00265	COG3584	3D domain protein
HTY60_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HTY60_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HTY60_RS00285	COG4466	Protein conserved in bacteria
HTY60_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HTY60_RS00305	COG0251	oxidation-reduction process
HTY60_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HTY60_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HTY60_RS00345	COG2002	toxin-antitoxin pair type II binding
HTY60_RS00350	COG2244	polysaccharide biosynthetic process
HTY60_RS00355	COG3956	TIGRFAM MazG family protein
HTY60_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HTY60_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HTY60_RS00380	COG1098	S1 RNA binding domain
HTY60_RS00395	COG2208	phosphoserine phosphatase activity
HTY60_RS00400	COG2304	oxidoreductase activity
HTY60_RS00405	COG0515	serine threonine protein kinase
HTY60_RS00410	COG0037	tRNA processing
HTY60_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HTY60_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HTY60_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HTY60_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HTY60_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
HTY60_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HTY60_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HTY60_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HTY60_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HTY60_RS00475	COG1396	sequence-specific DNA binding
HTY60_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HTY60_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HTY60_RS00565	COG4463	regulation of RNA biosynthetic process
HTY60_RS00570	COG3880	PFAM UvrB UvrC protein
HTY60_RS00580	COG0542	response to heat
HTY60_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HTY60_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HTY60_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
HTY60_RS00615	COG1045	serine acetyltransferase
HTY60_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HTY60_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HTY60_RS00635	COG3688	RNA-binding protein containing a PIN domain
HTY60_RS00640	COG1595	DNA-templated transcription, initiation
HTY60_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HTY60_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
HTY60_RS00680	COG2813	Specifically methylates the guanine in position
HTY60_RS00695	COG1358	cellular component organization or biogenesis
HTY60_RS00720	COG0596	Alpha beta hydrolase
HTY60_RS00830	COG0201	protein transport
HTY60_RS00840	COG0024	Methionine aminopeptidase
HTY60_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HTY60_RS00875	COG1122	ATPase activity
HTY60_RS00880	COG1122	ATPase activity
HTY60_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HTY60_RS00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HTY60_RS00905	COG2226	methyltransferase
HTY60_RS00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
HTY60_RS00920	COG0489	protein tyrosine kinase activity
HTY60_RS00930	COG2194	sulfuric ester hydrolase activity
HTY60_RS00935	COG0726	polysaccharide deacetylase
HTY60_RS00995	COG0738	Major facilitator superfamily
HTY60_RS01015	COG0659	secondary active sulfate transmembrane transporter activity
HTY60_RS01020	COG0385	Bile acid
HTY60_RS01025	COG2819	hydrolase of the alpha beta superfamily
HTY60_RS01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTY60_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTY60_RS01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HTY60_RS01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HTY60_RS01045	COG2207	Transcriptional regulator
HTY60_RS01050	COG3876	Protein conserved in bacteria
HTY60_RS01055	COG1472	Belongs to the glycosyl hydrolase 3 family
HTY60_RS01060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HTY60_RS01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HTY60_RS01065	COG1263	PTS System
HTY60_RS01080	COG1683	Conserved Protein
HTY60_RS01110	COG1595	DNA-templated transcription, initiation
HTY60_RS01115	COG5662	AntiSigma factor
HTY60_RS01120	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HTY60_RS01125	COG4856	YbbR-like protein
HTY60_RS01170	COG1346	cytolysis
HTY60_RS01175	COG1380	Effector of murein hydrolase LrgA
HTY60_RS01180	COG1846	Transcriptional regulator
HTY60_RS01185	COG1113	amino acid transport
HTY60_RS01190	COG1011	Hydrolase
HTY60_RS01195	COG4585	Histidine kinase
HTY60_RS01200	COG2197	response regulator
HTY60_RS01205	COG1131	(ABC) transporter
HTY60_RS01215	COG1511	domain protein
HTY60_RS01215	COG0842	Transport permease protein
HTY60_RS01245	COG0531	amino acid
HTY60_RS01255	COG0584	glycerophosphoryl diester phosphodiesterase
HTY60_RS01260	COG2271	Major facilitator Superfamily
HTY60_RS01270	COG2368	4-hydroxyphenylacetate
HTY60_RS01280	COG0371	Dehydrogenase
HTY60_RS01290	COG1183	phosphatidylcholine synthase activity
HTY60_RS01295	COG0586	Pfam SNARE associated Golgi protein
HTY60_RS01300	COG0688	phosphatidylethanolamine metabolic process
HTY60_RS01315	COG1301	dicarboxylic acid transport
HTY60_RS01320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HTY60_RS01325	COG0833	amino acid
HTY60_RS01330	COG2040	homocysteine
HTY60_RS01335	COG1115	amino acid carrier protein
HTY60_RS01345	COG4191	Histidine kinase
HTY60_RS01350	COG0784	Response regulator, receiver
HTY60_RS01355	COG3173	Aminoglycoside phosphotransferase
HTY60_RS01365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HTY60_RS01375	COG0346	lactoylglutathione lyase activity
HTY60_RS01380	COG2259	Doxx family
HTY60_RS01385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTY60_RS01400	COG3773	Cell wall hydrolase
HTY60_RS01405	COG3540	Alkaline phosphatase
HTY60_RS01410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HTY60_RS01415	COG0805	protein transport
HTY60_RS01420	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HTY60_RS01425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HTY60_RS01430	COG0477	Major facilitator Superfamily
HTY60_RS01435	COG1309	transcriptional regulator
HTY60_RS01445	COG3012	SEC-C Motif Domain Protein
HTY60_RS01445	COG1405	negative regulation of cell septum assembly
HTY60_RS01450	COG0667	Aldo Keto reductase
HTY60_RS01460	COG1595	DNA-templated transcription, initiation
HTY60_RS01465	COG1595	DNA-templated transcription, initiation
HTY60_RS01470	COG1876	peptidase activity
HTY60_RS01475	COG0457	Tetratricopeptide repeat
HTY60_RS01480	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS01485	COG0366	Alpha amylase catalytic
HTY60_RS01495	COG1695	Transcriptional regulator
HTY60_RS01500	COG0803	Belongs to the bacterial solute-binding protein 9 family
HTY60_RS01505	COG1121	(ABC) transporter
HTY60_RS01510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HTY60_RS01515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HTY60_RS01520	COG2310	stress, protein
HTY60_RS01525	COG2310	stress, protein
HTY60_RS01530	COG2310	stress, protein
HTY60_RS01535	COG0861	Integral membrane protein TerC family
HTY60_RS01545	COG3853	Toxic anion resistance protein (TelA)
HTY60_RS01550	COG0477	Major facilitator Superfamily
HTY60_RS01555	COG0517	IMP dehydrogenase activity
HTY60_RS01555	COG4175	Glycine betaine
HTY60_RS01560	COG4176	ABC-type proline glycine betaine transport system permease component
HTY60_RS01565	COG2113	Glycine betaine
HTY60_RS01570	COG1473	amidohydrolase
HTY60_RS01585	COG1714	RDD family
HTY60_RS01595	COG2814	Major facilitator Superfamily
HTY60_RS01600	COG1846	Transcriptional regulator
HTY60_RS01615	COG3403	YqcI/YcgG family
HTY60_RS01620	COG1113	amino acid transport
HTY60_RS01625	COG3665	Urea carboxylase-associated protein
HTY60_RS01635	COG1082	Xylose isomerase domain protein TIM barrel
HTY60_RS01645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HTY60_RS01650	COG3458	cephalosporin-C deacetylase activity
HTY60_RS01655	COG3541	Predicted nucleotidyltransferase
HTY60_RS01660	COG0506	proline dehydrogenase activity
HTY60_RS01665	COG1012	belongs to the aldehyde dehydrogenase family
HTY60_RS01675	COG2508	Transcriptional regulator
HTY60_RS01685	COG1587	Uroporphyrinogen-III synthase
HTY60_RS01685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HTY60_RS01690	COG2146	nitrite reductase [NAD(P)H] activity
HTY60_RS01695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HTY60_RS01705	COG0523	cobalamin synthesis protein
HTY60_RS01710	COG1063	alcohol dehydrogenase
HTY60_RS01715	COG1714	RDD family
HTY60_RS01725	COG2723	6-phospho-beta-galactosidase activity
HTY60_RS01735	COG3209	COG3209 Rhs family protein
HTY60_RS01740	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HTY60_RS01745	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HTY60_RS01750	COG1733	regulation of RNA biosynthetic process
HTY60_RS01755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HTY60_RS01760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HTY60_RS01765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HTY60_RS01770	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HTY60_RS01785	COG2364	Membrane
HTY60_RS01790	COG1126	abc transporter atp-binding protein
HTY60_RS01795	COG0765	amino acid transport
HTY60_RS01800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HTY60_RS01805	COG0583	DNA-binding transcription factor activity
HTY60_RS01810	COG0163	prenyltransferase activity
HTY60_RS01815	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HTY60_RS01830	COG3104	oligopeptide transport
HTY60_RS01835	COG5434	Belongs to the glycosyl hydrolase 28 family
HTY60_RS01845	COG0697	spore germination
HTY60_RS01855	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HTY60_RS01860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HTY60_RS01865	COG0456	acetyltransferase
HTY60_RS01870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HTY60_RS01875	COG0765	amino acid transport
HTY60_RS01880	COG1126	abc transporter atp-binding protein
HTY60_RS01885	COG1473	amidohydrolase
HTY60_RS01890	COG2079	MmgE PrpD family protein
HTY60_RS01895	COG1136	(ABC) transporter
HTY60_RS01900	COG0577	efflux transmembrane transporter activity
HTY60_RS01905	COG0745	RESPONSE REGULATOR receiver
HTY60_RS01910	COG5002	protein histidine kinase activity
HTY60_RS01910	COG3850	Histidine kinase
HTY60_RS01915	COG0457	Tetratricopeptide repeat
HTY60_RS01930	COG0527	aspartate kinase activity
HTY60_RS01935	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTY60_RS01940	COG4605	iron ion homeostasis
HTY60_RS01945	COG4604	ABC transporter, ATP-binding protein
HTY60_RS01950	COG4607	ABC-type enterochelin transport system periplasmic component
HTY60_RS01955	COG2814	Major facilitator Superfamily
HTY60_RS01960	COG1309	transcriptional regulator
HTY60_RS01965	COG0778	Nitroreductase
HTY60_RS01970	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HTY60_RS01975	COG0640	Transcriptional regulator
HTY60_RS01980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HTY60_RS01985	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HTY60_RS01990	COG1012	belongs to the aldehyde dehydrogenase family
HTY60_RS01995	COG4975	Glucose uptake
HTY60_RS02000	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS02005	COG4549	nuclear export factor GLE1
HTY60_RS02010	COG1276	copper resistance
HTY60_RS02010	COG2372	response to copper ion
HTY60_RS02015	COG1349	DNA-binding transcription factor activity
HTY60_RS02025	COG2213	PTS system mannitol-specific
HTY60_RS02030	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HTY60_RS02040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HTY60_RS02050	COG0561	phosphatase activity
HTY60_RS02060	COG1914	H( )-stimulated, divalent metal cation uptake system
HTY60_RS02070	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HTY60_RS02075	COG1984	allophanate hydrolase subunit 2
HTY60_RS02080	COG1414	Transcriptional regulator
HTY60_RS02085	COG2755	lipolytic protein G-D-S-L family
HTY60_RS02095	COG2329	Antibiotic biosynthesis monooxygenase
HTY60_RS02100	COG0768	penicillin binding
HTY60_RS02105	COG4989	oxidoreductase activity
HTY60_RS02110	COG3711	transcriptional antiterminator
HTY60_RS02115	COG0318	PFAM AMP-dependent synthetase and ligase
HTY60_RS02120	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS02125	COG1917	Cupin 2, conserved barrel domain protein
HTY60_RS02130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HTY60_RS02135	COG3871	stress protein (general stress protein 26)
HTY60_RS02145	COG2814	Major facilitator Superfamily
HTY60_RS02150	COG1522	sequence-specific DNA binding
HTY60_RS02155	COG0551	DNA topoisomerase type I activity
HTY60_RS02155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HTY60_RS02160	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HTY60_RS02165	COG3706	GGDEF domain
HTY60_RS02170	COG5298	Protein conserved in bacteria
HTY60_RS02175	COG1215	transferase activity, transferring glycosyl groups
HTY60_RS02185	COG0531	amino acid
HTY60_RS02190	COG0028	Belongs to the TPP enzyme family
HTY60_RS02225	COG0457	Tetratricopeptide repeat
HTY60_RS02240	COG1914	H( )-stimulated, divalent metal cation uptake system
HTY60_RS02250	COG4876	unkown
HTY60_RS02260	COG2076	Multidrug Resistance protein
HTY60_RS02265	COG2217	Heavy metal translocating P-type atpase
HTY60_RS02270	COG3729	General stress protein
HTY60_RS02275	COG0662	Cupin 2, conserved barrel domain protein
HTY60_RS02280	COG2329	Antibiotic biosynthesis monooxygenase
HTY60_RS02285	COG3546	catalase activity
HTY60_RS02295	COG3290	protein histidine kinase activity
HTY60_RS02300	COG4565	transcriptional regulatory protein
HTY60_RS02305	COG1301	dicarboxylic acid transport
HTY60_RS02310	COG0628	permease
HTY60_RS02315	COG1131	(ABC) transporter
HTY60_RS02320	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HTY60_RS02330	COG1960	acyl-CoA dehydrogenase activity
HTY60_RS02345	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HTY60_RS02350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTY60_RS02360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HTY60_RS02365	COG0513	Belongs to the DEAD box helicase family
HTY60_RS02370	COG3402	PFAM membrane-flanked domain
HTY60_RS02375	COG3428	Bacterial PH domain
HTY60_RS02380	COG0705	Rhomboid family
HTY60_RS02390	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HTY60_RS02395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HTY60_RS02400	COG0864	Transcriptional regulator
HTY60_RS02405	COG2337	Toxic component of a toxin-antitoxin (TA) module
HTY60_RS02410	COG1366	Belongs to the anti-sigma-factor antagonist family
HTY60_RS02415	COG1366	Belongs to the anti-sigma-factor antagonist family
HTY60_RS02420	COG2172	sigma factor antagonist activity
HTY60_RS02425	COG2208	phosphoserine phosphatase activity
HTY60_RS02430	COG1366	Belongs to the anti-sigma-factor antagonist family
HTY60_RS02440	COG1191	sigma factor activity
HTY60_RS02445	COG2208	phosphoserine phosphatase activity
HTY60_RS02450	COG2183	response to ionizing radiation
HTY60_RS02505	COG0860	N-Acetylmuramoyl-L-alanine amidase
HTY60_RS02525	COG1191	sigma factor activity
HTY60_RS02545	COG0582	viral genome integration into host DNA
HTY60_RS02550	COG2856	Zn peptidase
HTY60_RS02555	COG1396	sequence-specific DNA binding
HTY60_RS02575	COG1674	ftsk spoiiie
HTY60_RS02580	COG2946	Replication initiation factor
HTY60_RS02635	COG0433	COG0433 Predicted ATPase
HTY60_RS02645	COG5644	endopeptidase inhibitor activity
HTY60_RS02650	COG0741	lytic transglycosylase activity
HTY60_RS02650	COG0791	NLP P60 protein
HTY60_RS02685	COG0457	Tetratricopeptide repeat
HTY60_RS02695	COG5444	nuclease activity
HTY60_RS02710	COG1959	2 iron, 2 sulfur cluster binding
HTY60_RS02720	COG1278	Cold shock
HTY60_RS02725	COG1794	racemase activity, acting on amino acids and derivatives
HTY60_RS02740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HTY60_RS02745	COG0477	Major facilitator Superfamily
HTY60_RS02760	COG0277	FAD linked oxidase domain protein
HTY60_RS02780	COG0662	Cupin 2, conserved barrel domain protein
HTY60_RS02785	COG0456	acetyltransferase
HTY60_RS02790	COG3708	Transcriptional regulator
HTY60_RS02790	COG2207	Transcriptional regulator
HTY60_RS02810	COG1064	alcohol dehydrogenase
HTY60_RS02815	COG0789	Transcriptional regulator
HTY60_RS02825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HTY60_RS02830	COG2808	Putative FMN-binding domain
HTY60_RS02835	COG2814	Major facilitator Superfamily
HTY60_RS02840	COG1309	transcriptional regulator
HTY60_RS02845	COG0697	spore germination
HTY60_RS02850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HTY60_RS02855	COG5577	PFAM Coat F domain
HTY60_RS02865	COG1063	alcohol dehydrogenase
HTY60_RS02870	COG5577	PFAM Coat F domain
HTY60_RS02880	COG2409	Drug exporters of the RND superfamily
HTY60_RS02885	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HTY60_RS02895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HTY60_RS02900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HTY60_RS02910	COG2814	Major facilitator Superfamily
HTY60_RS02915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HTY60_RS02925	COG0730	response to heat
HTY60_RS02930	COG0456	acetyltransferase
HTY60_RS02935	COG4978	Transcriptional regulator
HTY60_RS02935	COG0789	Transcriptional regulator
HTY60_RS02940	COG0697	spore germination
HTY60_RS02945	COG1051	belongs to the nudix hydrolase family
HTY60_RS02950	COG0596	Alpha beta hydrolase
HTY60_RS02955	COG0473	3-isopropylmalate dehydrogenase activity
HTY60_RS02960	COG1802	Transcriptional regulator
HTY60_RS02975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HTY60_RS02985	COG1388	LysM domain
HTY60_RS02990	COG2814	Major facilitator Superfamily
HTY60_RS02995	COG2188	Transcriptional regulator
HTY60_RS03000	COG2186	Transcriptional regulator
HTY60_RS03005	COG2807	transmembrane transport
HTY60_RS03010	COG2076	Multidrug Resistance protein
HTY60_RS03015	COG2076	Multidrug Resistance protein
HTY60_RS03020	COG1309	transcriptional regulator
HTY60_RS03025	COG0531	amino acid
HTY60_RS03035	COG3832	glyoxalase III activity
HTY60_RS03040	COG0604	alcohol dehydrogenase
HTY60_RS03045	COG2814	Major facilitator Superfamily
HTY60_RS03090	COG0802	atpase or kinase
HTY60_RS03095	COG1214	PFAM Peptidase M22, glycoprotease
HTY60_RS03100	COG0456	acetyltransferase
HTY60_RS03105	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HTY60_RS03110	COG0488	(ABC) transporter
HTY60_RS03125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HTY60_RS03130	COG0805	protein transport
HTY60_RS03140	COG1266	CAAX protease self-immunity
HTY60_RS03160	COG2856	Zn peptidase
HTY60_RS03175	COG1396	sequence-specific DNA binding
HTY60_RS03220	COG3723	Recombinational DNA repair protein, rece pathway
HTY60_RS03225	COG3935	DnaD domain protein
HTY60_RS03230	COG1484	DNA-dependent DNA replication
HTY60_RS03335	COG1595	DNA-templated transcription, initiation
HTY60_RS03360	COG5484	DNA packaging
HTY60_RS03365	COG1783	phage Terminase large subunit
HTY60_RS03490	COG3409	Peptidoglycan-binding domain 1 protein
HTY60_RS03490	COG1388	LysM domain
HTY60_RS03490	COG5632	N-Acetylmuramoyl-L-alanine amidase
HTY60_RS03500	COG3409	Peptidoglycan-binding domain 1 protein
HTY60_RS03515	COG0457	Tetratricopeptide repeat
HTY60_RS03520	COG1063	alcohol dehydrogenase
HTY60_RS03525	COG2211	Major facilitator Superfamily
HTY60_RS03530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HTY60_RS03540	COG1842	Phage shock protein A
HTY60_RS03545	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HTY60_RS03550	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HTY60_RS03555	COG4260	virion core protein, lumpy skin disease virus
HTY60_RS03560	COG2755	lipolytic protein G-D-S-L family
HTY60_RS03560	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HTY60_RS03570	COG1595	DNA-templated transcription, initiation
HTY60_RS03575	COG1063	alcohol dehydrogenase
HTY60_RS03580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HTY60_RS03585	COG0823	Involved in the tonB-independent uptake of proteins
HTY60_RS03600	COG2132	Multicopper oxidase
HTY60_RS03605	COG1113	amino acid transport
HTY60_RS03615	COG0714	Associated with various cellular activities
HTY60_RS03620	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HTY60_RS03625	COG1305	Transglutaminase-like
HTY60_RS03645	COG2252	PERMEase
HTY60_RS03650	COG3064	Membrane
HTY60_RS03670	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HTY60_RS03675	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HTY60_RS03680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HTY60_RS03685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HTY60_RS03690	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HTY60_RS03705	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HTY60_RS03715	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HTY60_RS03720	COG0138	bifunctional purine biosynthesis protein purh
HTY60_RS03725	COG0151	Belongs to the GarS family
HTY60_RS03730	COG1522	sequence-specific DNA binding
HTY60_RS03735	COG0531	amino acid
HTY60_RS03745	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HTY60_RS03750	COG1470	cell adhesion involved in biofilm formation
HTY60_RS03755	COG4496	protein, YerC YecD
HTY60_RS03760	COG0069	glutamate synthase activity
HTY60_RS03770	COG0210	DNA helicase
HTY60_RS03780	COG4851	CamS sex pheromone cAM373 precursor
HTY60_RS03785	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HTY60_RS03790	COG1285	pathogenesis
HTY60_RS03795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HTY60_RS03815	COG1309	transcriptional regulator
HTY60_RS03820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HTY60_RS03825	COG1597	lipid kinase activity
HTY60_RS03830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HTY60_RS03845	COG1131	(ABC) transporter
HTY60_RS03875	COG5444	nuclease activity
HTY60_RS03880	COG5444	nuclease activity
HTY60_RS03910	COG3546	catalase activity
HTY60_RS03915	COG0454	-acetyltransferase
HTY60_RS03925	COG2323	membrane
HTY60_RS03930	COG2329	Antibiotic biosynthesis monooxygenase
HTY60_RS03935	COG0346	lactoylglutathione lyase activity
HTY60_RS03940	COG1366	Belongs to the anti-sigma-factor antagonist family
HTY60_RS03945	COG5583	Uncharacterized small protein (DUF2292)
HTY60_RS03950	COG0196	riboflavin kinase activity
HTY60_RS03955	COG0670	Belongs to the BI1 family
HTY60_RS03960	COG1846	Transcriptional regulator
HTY60_RS03965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HTY60_RS03975	COG2124	cytochrome p450
HTY60_RS03975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HTY60_RS03985	COG1368	sulfuric ester hydrolase activity
HTY60_RS03990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HTY60_RS03995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HTY60_RS04000	COG1442	glycosyl transferase family 8
HTY60_RS04005	COG1216	Glycosyl transferase, family 2
HTY60_RS04010	COG1442	glycosyl transferase family 8
HTY60_RS04015	COG2223	nitrite transmembrane transporter activity
HTY60_RS04020	COG0531	amino acid
HTY60_RS04025	COG1012	belongs to the aldehyde dehydrogenase family
HTY60_RS04030	COG0840	transmembrane signaling receptor activity
HTY60_RS04035	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS04040	COG0457	Tetratricopeptide repeat
HTY60_RS04040	COG0463	Glycosyl transferase, family 2
HTY60_RS04045	COG0488	(ABC) transporter
HTY60_RS04050	COG0789	Transcriptional regulator
HTY60_RS04055	COG2814	Major facilitator Superfamily
HTY60_RS04060	COG0488	(ABC) transporter
HTY60_RS04065	COG0513	Belongs to the DEAD box helicase family
HTY60_RS04085	COG3866	Pectate lyase
HTY60_RS04090	COG0471	metal ion transport
HTY60_RS04110	COG2972	Histidine kinase
HTY60_RS04110	COG0745	RESPONSE REGULATOR receiver
HTY60_RS04125	COG3764	Sortase (surface protein transpeptidase)
HTY60_RS04130	COG3290	protein histidine kinase activity
HTY60_RS04135	COG4565	transcriptional regulatory protein
HTY60_RS04140	COG3181	Tripartite tricarboxylate transporter family receptor
HTY60_RS04145	COG2851	Citrate transporter
HTY60_RS04155	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HTY60_RS04165	COG2258	MOSC domain
HTY60_RS04185	COG0024	Methionine aminopeptidase
HTY60_RS04190	COG1263	PTS System
HTY60_RS04190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HTY60_RS04200	COG1368	sulfuric ester hydrolase activity
HTY60_RS04210	COG0071	Belongs to the small heat shock protein (HSP20) family
HTY60_RS04230	COG0366	Alpha amylase catalytic
HTY60_RS04235	COG2188	Transcriptional regulator
HTY60_RS04240	COG0778	Nitroreductase
HTY60_RS04255	COG0737	Belongs to the 5'-nucleotidase family
HTY60_RS04260	COG0693	protein deglycase activity
HTY60_RS04265	COG1609	Transcriptional regulator
HTY60_RS04280	COG2814	Major facilitator Superfamily
HTY60_RS04290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HTY60_RS04295	COG4980	gas vesicle protein
HTY60_RS04300	COG1295	ribonuclease BN
HTY60_RS04305	COG0477	Major facilitator Superfamily
HTY60_RS04310	COG0387	Pfam Sodium calcium exchanger
HTY60_RS04320	COG0668	transmembrane transport
HTY60_RS04325	COG0535	radical SAM domain protein
HTY60_RS04335	COG0726	polysaccharide deacetylase
HTY60_RS04350	COG0598	Magnesium transport protein CorA
HTY60_RS04355	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HTY60_RS04360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HTY60_RS04370	COG1132	(ABC) transporter
HTY60_RS04375	COG0515	serine threonine protein kinase
HTY60_RS04385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HTY60_RS04390	COG4637	Psort location Cytoplasmic, score
HTY60_RS04395	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HTY60_RS04400	COG0022	dehydrogenase e1 component
HTY60_RS04405	COG0508	dehydrogenase complex catalyzes the overall conversion of
HTY60_RS04410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HTY60_RS04415	COG3284	Transcriptional regulator
HTY60_RS04425	COG1486	melibiose metabolic process
HTY60_RS04430	COG1737	Transcriptional regulator
HTY60_RS04435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HTY60_RS04435	COG1263	PTS System
HTY60_RS04440	COG5434	Belongs to the glycosyl hydrolase 28 family
HTY60_RS04445	COG1132	(ABC) transporter
HTY60_RS04450	COG1132	(ABC) transporter
HTY60_RS04455	COG2259	Doxx family
HTY60_RS04460	COG2514	catechol 2,3-dioxygenase activity
HTY60_RS04470	COG1695	Transcriptional regulator
HTY60_RS04475	COG2249	NAD(P)H dehydrogenase (quinone) activity
HTY60_RS04480	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HTY60_RS04485	COG2732	(Barnase) inhibitor
HTY60_RS04490	COG2318	DinB family
HTY60_RS04495	COG2814	Major facilitator Superfamily
HTY60_RS04500	COG1846	Transcriptional regulator
HTY60_RS04505	COG0392	lysyltransferase activity
HTY60_RS04505	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HTY60_RS04510	COG0384	phenazine biosynthesis protein PhzF
HTY60_RS04515	COG0778	Nitroreductase
HTY60_RS04530	COG1090	epimerase
HTY60_RS04555	COG3591	Belongs to the peptidase S1B family
HTY60_RS04570	COG3103	Sh3 type 3 domain protein
HTY60_RS04590	COG0463	Glycosyl transferase, family 2
HTY60_RS04595	COG4485	Bacterial membrane protein, YfhO
HTY60_RS04600	COG1988	membrane-bound metal-dependent
HTY60_RS04605	COG0582	viral genome integration into host DNA
HTY60_RS04645	COG3645	SOS response
HTY60_RS04645	COG3646	Phage regulatory protein
HTY60_RS04670	COG0305	Participates in initiation and elongation during chromosome replication
HTY60_RS04690	COG1595	DNA-templated transcription, initiation
HTY60_RS04735	COG0740	serine-type endopeptidase activity
HTY60_RS04850	COG1194	a g-specific adenine glycosylase
HTY60_RS04860	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS04880	COG1132	(ABC) transporter
HTY60_RS04885	COG4129	membrane
HTY60_RS04895	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HTY60_RS04900	COG0735	belongs to the Fur family
HTY60_RS05005	COG4974	Belongs to the 'phage' integrase family
HTY60_RS05065	COG1484	DNA-dependent DNA replication
HTY60_RS05090	COG3655	Transcriptional regulator
HTY60_RS05130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HTY60_RS05130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HTY60_RS05170	COG1780	Probably involved in ribonucleotide reductase function
HTY60_RS05175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HTY60_RS05190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HTY60_RS05200	COG0756	dUTP diphosphatase activity
HTY60_RS05205	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HTY60_RS05240	COG1595	DNA-templated transcription, initiation
HTY60_RS05260	COG1793	dna ligase
HTY60_RS05315	COG0582	viral genome integration into host DNA
HTY60_RS05400	COG1705	Flagellar rod assembly protein muramidase FlgJ
HTY60_RS05410	COG5434	Belongs to the glycosyl hydrolase 28 family
HTY60_RS05435	COG5632	N-Acetylmuramoyl-L-alanine amidase
HTY60_RS05435	COG3409	Peptidoglycan-binding domain 1 protein
HTY60_RS05435	COG1388	LysM domain
HTY60_RS05475	COG3340	Belongs to the peptidase S51 family
HTY60_RS05485	COG0277	FAD linked oxidase domain protein
HTY60_RS05495	COG0747	negative chemotaxis
HTY60_RS05500	COG0601	transmembrane transport
HTY60_RS05505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HTY60_RS05510	COG0444	Belongs to the ABC transporter superfamily
HTY60_RS05520	COG0753	catalase activity
HTY60_RS05530	COG1116	anion transmembrane transporter activity
HTY60_RS05535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HTY60_RS05540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HTY60_RS05565	COG1476	TRANSCRIPTIONal
HTY60_RS05575	COG3382	B3 4 domain protein
HTY60_RS05580	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HTY60_RS05590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HTY60_RS05595	COG0789	Transcriptional regulator
HTY60_RS05600	COG1664	Polymer-forming cytoskeletal
HTY60_RS05605	COG1664	Polymer-forming cytoskeletal
HTY60_RS05610	COG2766	serine protein kinase
HTY60_RS05620	COG1846	Transcriptional regulator
HTY60_RS05625	COG1566	PFAM secretion protein HlyD family protein
HTY60_RS05630	COG2814	Major facilitator Superfamily
HTY60_RS05635	COG0655	NAD(P)H dehydrogenase (quinone) activity
HTY60_RS05650	COG1725	Transcriptional regulator
HTY60_RS05655	COG1131	(ABC) transporter
HTY60_RS05660	COG1131	(ABC) transporter
HTY60_RS05665	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HTY60_RS05670	COG1278	Cold shock
HTY60_RS05675	COG1464	Belongs to the NlpA lipoprotein family
HTY60_RS05680	COG3706	GGDEF domain
HTY60_RS05685	COG1823	symporter activity
HTY60_RS05690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HTY60_RS05710	COG5577	PFAM Coat F domain
HTY60_RS05715	COG1525	nuclease
HTY60_RS05715	COG0737	Belongs to the 5'-nucleotidase family
HTY60_RS05715	COG4085	toxin activity
HTY60_RS05720	COG3764	Sortase (surface protein transpeptidase)
HTY60_RS05725	COG0564	pseudouridine synthase activity
HTY60_RS05735	COG0517	IMP dehydrogenase activity
HTY60_RS05740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HTY60_RS05745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HTY60_RS05745	COG3153	acetyltransferase
HTY60_RS05750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HTY60_RS05755	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HTY60_RS05760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HTY60_RS05770	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HTY60_RS05775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HTY60_RS05780	COG2203	Gaf domain
HTY60_RS05780	COG4585	Histidine kinase
HTY60_RS05785	COG2197	response regulator
HTY60_RS05790	COG0431	NADPH-dependent FMN reductase
HTY60_RS05805	COG1388	LysM domain
HTY60_RS05805	COG0791	NLP P60 protein
HTY60_RS05810	COG1959	2 iron, 2 sulfur cluster binding
HTY60_RS05815	COG0668	transmembrane transport
HTY60_RS05820	COG2719	SpoVR family
HTY60_RS05825	COG1785	Belongs to the alkaline phosphatase family
HTY60_RS05830	COG1388	LysM domain
HTY60_RS05830	COG0791	NLP P60 protein
HTY60_RS05835	COG0583	DNA-binding transcription factor activity
HTY60_RS05840	COG0372	Belongs to the citrate synthase family
HTY60_RS05845	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS05850	COG0531	amino acid
HTY60_RS05855	COG0733	neurotransmitter:sodium symporter activity
HTY60_RS05870	COG1595	DNA-templated transcription, initiation
HTY60_RS05875	COG0204	Acyl-transferase
HTY60_RS05880	COG1253	flavin adenine dinucleotide binding
HTY60_RS05885	COG0789	Transcriptional regulator
HTY60_RS05890	COG0436	Aminotransferase
HTY60_RS05895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HTY60_RS05900	COG1253	flavin adenine dinucleotide binding
HTY60_RS05905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HTY60_RS05910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HTY60_RS05915	COG0584	glycerophosphoryl diester phosphodiesterase
HTY60_RS05925	COG0668	transmembrane transport
HTY60_RS05930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HTY60_RS05935	COG0726	polysaccharide deacetylase
HTY60_RS05940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HTY60_RS05945	COG3226	Transcriptional regulator
HTY60_RS05955	COG0589	response to stress
HTY60_RS05960	COG1132	(ABC) transporter
HTY60_RS05965	COG1132	(ABC) transporter
HTY60_RS05970	COG0702	epimerase
HTY60_RS05985	COG0189	ligase activity
HTY60_RS05990	COG0189	ligase activity
HTY60_RS06005	COG0561	phosphatase activity
HTY60_RS06010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HTY60_RS06020	COG0475	glutathione-regulated potassium exporter activity
HTY60_RS06025	COG0490	domain, Protein
HTY60_RS06035	COG1024	Enoyl-CoA hydratase
HTY60_RS06045	COG4152	abc transporter atp-binding protein
HTY60_RS06050	COG1668	transmembrane transport
HTY60_RS06055	COG0420	3'-5' exonuclease activity
HTY60_RS06075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HTY60_RS06110	COG4980	gas vesicle protein
HTY60_RS06125	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HTY60_RS06130	COG0537	adenosine 5'-monophosphoramidase activity
HTY60_RS06135	COG1131	(ABC) transporter
HTY60_RS06140	COG4473	ABC transporter
HTY60_RS06150	COG1473	amidohydrolase
HTY60_RS06155	COG3069	C4-dicarboxylate transmembrane transporter activity
HTY60_RS06160	COG2329	Antibiotic biosynthesis monooxygenase
HTY60_RS06165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HTY60_RS06185	COG1309	transcriptional regulator
HTY60_RS06190	COG1511	domain protein
HTY60_RS06195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HTY60_RS06205	COG1363	Peptidase, m42
HTY60_RS06210	COG1301	dicarboxylic acid transport
HTY60_RS06220	COG1234	tRNA 3'-trailer cleavage
HTY60_RS06225	COG0095	Lipoate-protein ligase
HTY60_RS06230	COG0702	epimerase
HTY60_RS06235	COG0318	PFAM AMP-dependent synthetase and ligase
HTY60_RS06245	COG0501	Belongs to the peptidase M48B family
HTY60_RS06250	COG1404	Belongs to the peptidase S8 family
HTY60_RS06255	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HTY60_RS06260	COG0406	alpha-ribazole phosphatase activity
HTY60_RS06265	COG0183	Belongs to the thiolase family
HTY60_RS06275	COG1268	BioY protein
HTY60_RS06290	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS06300	COG4903	ComK protein
HTY60_RS06305	COG5646	InterPro IPR014922
HTY60_RS06330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HTY60_RS06345	COG0398	Pfam SNARE associated Golgi protein
HTY60_RS06350	COG0681	Belongs to the peptidase S26 family
HTY60_RS06355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HTY60_RS06360	COG1846	Transcriptional regulator
HTY60_RS06365	COG3180	Ammonia monooxygenase
HTY60_RS06370	COG2814	Major facilitator Superfamily
HTY60_RS06380	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HTY60_RS06385	COG2323	membrane
HTY60_RS06400	COG0420	3'-5' exonuclease activity
HTY60_RS06405	COG0419	ATPase involved in DNA repair
HTY60_RS06410	COG1403	HNH endonuclease
HTY60_RS06450	COG0179	Fumarylacetoacetate (FAA) hydrolase
HTY60_RS06460	COG1404	Belongs to the peptidase S8 family
HTY60_RS06470	COG0367	asparagine synthase
HTY60_RS06475	COG1562	ergosterol biosynthetic process
HTY60_RS06480	COG0534	Mate efflux family protein
HTY60_RS06485	COG2207	Transcriptional regulator
HTY60_RS06485	COG1917	Cupin 2, conserved barrel domain protein
HTY60_RS06490	COG1609	Transcriptional regulator
HTY60_RS06495	COG0673	inositol 2-dehydrogenase activity
HTY60_RS06500	COG2318	DinB family
HTY60_RS06505	COG1279	arginine transmembrane transporter activity
HTY60_RS06510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HTY60_RS06515	COG1357	PFAM Pentapeptide repeats (8 copies)
HTY60_RS06520	COG2153	protein acetylation
HTY60_RS06525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HTY60_RS06525	COG0646	methionine synthase
HTY60_RS06535	COG2996	Protein conserved in bacteria
HTY60_RS06545	COG0840	transmembrane signaling receptor activity
HTY60_RS06555	COG1307	EDD domain protein, DegV family
HTY60_RS06560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HTY60_RS06580	COG0561	phosphatase activity
HTY60_RS06585	COG1073	alpha beta
HTY60_RS06590	COG2151	metal-sulfur cluster biosynthetic enzyme
HTY60_RS06600	COG0277	FAD linked oxidase domain protein
HTY60_RS06605	COG2271	Major facilitator Superfamily
HTY60_RS06615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HTY60_RS06625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HTY60_RS06630	COG0505	Belongs to the CarA family
HTY60_RS06635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HTY60_RS06640	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HTY60_RS06655	COG2267	carboxylic ester hydrolase activity
HTY60_RS06665	COG1744	ABC transporter substrate-binding protein PnrA-like
HTY60_RS06680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HTY60_RS06685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HTY60_RS06690	COG5504	Zn-dependent protease
HTY60_RS06695	COG0444	Belongs to the ABC transporter superfamily
HTY60_RS06700	COG4608	Belongs to the ABC transporter superfamily
HTY60_RS06710	COG0601	transmembrane transport
HTY60_RS06715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HTY60_RS06725	COG0180	Tryptophanyl-tRNA synthetase
HTY60_RS06730	COG4166	transmembrane transport
HTY60_RS06735	COG0601	transmembrane transport
HTY60_RS06740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HTY60_RS06745	COG0444	Belongs to the ABC transporter superfamily
HTY60_RS06750	COG4608	Belongs to the ABC transporter superfamily
HTY60_RS06760	COG0456	acetyltransferase
HTY60_RS06765	COG1393	Belongs to the ArsC family
HTY60_RS06770	COG0861	Integral membrane protein TerC family
HTY60_RS06780	COG4862	establishment of competence for transformation
HTY60_RS06785	COG4469	Competence protein
HTY60_RS06790	COG1164	Oligoendopeptidase f
HTY60_RS06805	COG2346	COG2346, Truncated hemoglobins
HTY60_RS06810	COG0741	lytic transglycosylase activity
HTY60_RS06815	COG4116	CYTH
HTY60_RS06825	COG2357	RelA SpoT domain protein
HTY60_RS06830	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HTY60_RS06835	COG0564	pseudouridine synthase activity
HTY60_RS06850	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HTY60_RS06855	COG0352	thiamine-phosphate diphosphorylase activity
HTY60_RS06860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HTY60_RS06865	COG2104	thiamine diphosphate biosynthetic process
HTY60_RS06875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HTY60_RS06880	COG0351	phosphomethylpyrimidine kinase
HTY60_RS06885	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HTY60_RS06940	COG0210	DNA helicase
HTY60_RS06950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HTY60_RS06960	COG1131	(ABC) transporter
HTY60_RS06970	COG2153	protein acetylation
HTY60_RS06980	COG2382	esterase
HTY60_RS06985	COG0626	cystathionine gamma-synthase activity
HTY60_RS06990	COG0626	cystathionine gamma-synthase activity
HTY60_RS07015	COG4282	regulation of fungal-type cell wall biogenesis
HTY60_RS07045	COG5290	Psort location Cytoplasmic, score
HTY60_RS07065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HTY60_RS07105	COG2367	Beta-lactamase
HTY60_RS07110	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HTY60_RS07115	COG0477	Major facilitator Superfamily
HTY60_RS07120	COG1846	Transcriptional regulator
HTY60_RS07130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HTY60_RS07130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HTY60_RS07135	COG1447	Phosphotransferase system cellobiose-specific component IIA
HTY60_RS07140	COG2723	6-phospho-beta-galactosidase activity
HTY60_RS07145	COG1349	DNA-binding transcription factor activity
HTY60_RS07165	COG1285	pathogenesis
HTY60_RS07175	COG2205	protein histidine kinase activity
HTY60_RS07195	COG0390	transport system, permease component
HTY60_RS07200	COG1587	Uroporphyrinogen-III synthase
HTY60_RS07210	COG1819	glycosyl
HTY60_RS07215	COG2124	cytochrome p450
HTY60_RS07220	COG2427	Protein of unknown function (DUF1641)
HTY60_RS07235	COG0697	spore germination
HTY60_RS07240	COG4297	protein containing double-stranded beta helix domain
HTY60_RS07250	COG1252	NADH dehydrogenase
HTY60_RS07260	COG1609	Transcriptional regulator
HTY60_RS07270	COG0745	RESPONSE REGULATOR receiver
HTY60_RS07275	COG5002	protein histidine kinase activity
HTY60_RS07290	COG0730	response to heat
HTY60_RS07295	COG2318	DinB family
HTY60_RS07300	COG0457	Tetratricopeptide repeat
HTY60_RS07310	COG1388	LysM domain
HTY60_RS07310	COG3409	Peptidoglycan-binding domain 1 protein
HTY60_RS07310	COG5632	N-Acetylmuramoyl-L-alanine amidase
HTY60_RS07320	COG4195	phage-related replication protein
HTY60_RS07325	COG2856	Zn peptidase
HTY60_RS07330	COG1396	sequence-specific DNA binding
HTY60_RS07340	COG1522	sequence-specific DNA binding
HTY60_RS07345	COG1484	DNA-dependent DNA replication
HTY60_RS07365	COG1595	DNA-templated transcription, initiation
HTY60_RS07370	COG5484	DNA packaging
HTY60_RS07370	COG3728	DNA packaging
HTY60_RS07375	COG1783	phage Terminase large subunit
HTY60_RS07380	COG5518	Phage portal protein
HTY60_RS07385	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HTY60_RS07390	COG4653	Phage capsid family
HTY60_RS07440	COG5412	phage tail tape measure protein
HTY60_RS07440	COG3953	SLT domain
HTY60_RS07440	COG3953	SLT domain
HTY60_RS07440	COG5412	phage tail tape measure protein
HTY60_RS07440	COG3953	SLT domain
HTY60_RS07440	COG5412	phage tail tape measure protein
HTY60_RS07445	COG1652	LysM domain
HTY60_RS07450	COG4193	domain, Protein
HTY60_RS07460	COG3628	GPW Gp25 family protein
HTY60_RS07465	COG3299	homolog of phage Mu protein gp47
HTY60_RS07470	COG3778	Protein conserved in bacteria
HTY60_RS07520	COG3409	Peptidoglycan-binding domain 1 protein
HTY60_RS07520	COG5632	N-Acetylmuramoyl-L-alanine amidase
HTY60_RS07535	COG0306	phosphate transporter
HTY60_RS07540	COG1392	Phosphate transport regulator
HTY60_RS07545	COG0531	amino acid
HTY60_RS07550	COG0346	lactoylglutathione lyase activity
HTY60_RS07555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HTY60_RS07560	COG0463	Glycosyl transferase, family 2
HTY60_RS07570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HTY60_RS07575	COG0477	Major facilitator Superfamily
HTY60_RS07580	COG2362	D-Aminopeptidase
HTY60_RS07585	COG0601	transmembrane transport
HTY60_RS07590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HTY60_RS07595	COG0444	Belongs to the ABC transporter superfamily
HTY60_RS07600	COG4166	transmembrane transport
HTY60_RS07605	COG1619	proteins homologs of microcin C7 resistance protein MccF
HTY60_RS07610	COG4948	Mandelate Racemase Muconate Lactonizing
HTY60_RS07615	COG0791	NLP P60 protein
HTY60_RS07620	COG4608	Belongs to the ABC transporter superfamily
HTY60_RS07625	COG2706	6-phosphogluconolactonase activity
HTY60_RS07630	COG1834	amidinotransferase
HTY60_RS07635	COG1607	acyl-coa hydrolase
HTY60_RS07640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HTY60_RS07645	COG2076	Multidrug Resistance protein
HTY60_RS07650	COG2076	Multidrug Resistance protein
HTY60_RS07655	COG0788	formyltetrahydrofolate deformylase activity
HTY60_RS07660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HTY60_RS07670	COG1764	response to oxidative stress
HTY60_RS07675	COG1846	Transcriptional regulator
HTY60_RS07680	COG1764	response to oxidative stress
HTY60_RS07695	COG0463	Glycosyl transferase, family 2
HTY60_RS07695	COG0457	Tetratricopeptide repeat
HTY60_RS07710	COG2814	Major facilitator Superfamily
HTY60_RS07715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HTY60_RS07725	COG1404	Belongs to the peptidase S8 family
HTY60_RS07730	COG1366	Belongs to the anti-sigma-factor antagonist family
HTY60_RS07735	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HTY60_RS07740	COG1122	ATPase activity
HTY60_RS07745	COG4721	ABC-type cobalt transport system, permease component
HTY60_RS07750	COG3858	chitin binding
HTY60_RS07750	COG1388	LysM domain
HTY60_RS07760	COG2239	Acts as a magnesium transporter
HTY60_RS07765	COG0789	Transcriptional regulator
HTY60_RS07780	COG1846	Transcriptional regulator
HTY60_RS07785	COG0726	polysaccharide deacetylase
HTY60_RS07790	COG3285	dna ligase
HTY60_RS07790	COG1793	dna ligase
HTY60_RS07795	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HTY60_RS07800	COG3300	MHYT domain
HTY60_RS07800	COG5001	Diguanylate cyclase
HTY60_RS07805	COG0586	Pfam SNARE associated Golgi protein
HTY60_RS07810	COG0861	Integral membrane protein TerC family
HTY60_RS07815	COG1191	sigma factor activity
HTY60_RS07840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HTY60_RS07845	COG2323	membrane
HTY60_RS07855	COG3594	Acyltransferase
HTY60_RS07860	COG5002	protein histidine kinase activity
HTY60_RS07865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HTY60_RS07880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HTY60_RS07885	COG0436	Aminotransferase
HTY60_RS07915	COG3852	Histidine kinase
HTY60_RS07920	COG1846	Transcriptional regulator
HTY60_RS07925	COG1360	Flagellar Motor Protein
HTY60_RS07930	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HTY60_RS07935	COG0542	response to heat
HTY60_RS07940	COG3949	Membrane
HTY60_RS07960	COG0720	synthase
HTY60_RS07965	COG0602	queuosine metabolic process
HTY60_RS07980	COG4873	Protein conserved in bacteria
HTY60_RS07990	COG3773	Cell wall hydrolase
HTY60_RS07995	COG2244	polysaccharide biosynthetic process
HTY60_RS08000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTY60_RS08005	COG2217	Heavy metal translocating P-type atpase
HTY60_RS08010	COG0006	proline dipeptidase activity
HTY60_RS08015	COG1609	Transcriptional regulator
HTY60_RS08025	COG2190	(PTS) system
HTY60_RS08025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HTY60_RS08025	COG1263	PTS System
HTY60_RS08030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HTY60_RS08035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HTY60_RS08045	COG1533	DNA photolyase activity
HTY60_RS08050	COG0840	transmembrane signaling receptor activity
HTY60_RS08055	COG2084	Dehydrogenase
HTY60_RS08065	COG2340	Cysteine-rich secretory protein family
HTY60_RS08070	COG0768	penicillin binding
HTY60_RS08075	COG4191	Histidine kinase
HTY60_RS08080	COG0436	Aminotransferase
HTY60_RS08090	COG0835	chemotaxis
HTY60_RS08090	COG0784	Response regulator, receiver
HTY60_RS08100	COG2814	Major facilitator Superfamily
HTY60_RS08105	COG1376	ErfK ybiS ycfS ynhG family protein
HTY60_RS08110	COG1408	metallophosphoesterase
HTY60_RS08115	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS08125	COG2200	EAL domain
HTY60_RS08130	COG4703	Protein of unknown function (DUF1797)
HTY60_RS08135	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HTY60_RS08145	COG0517	IMP dehydrogenase activity
HTY60_RS08150	COG0583	DNA-binding transcription factor activity
HTY60_RS08155	COG0716	FMN binding
HTY60_RS08165	COG0716	FMN binding
HTY60_RS08185	COG0668	transmembrane transport
HTY60_RS08215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HTY60_RS08220	COG0303	'Molybdopterin
HTY60_RS08225	COG1763	Mo-molybdopterin cofactor biosynthetic process
HTY60_RS08230	COG0314	molybdopterin synthase activity
HTY60_RS08235	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HTY60_RS08245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HTY60_RS08250	COG1136	(ABC) transporter
HTY60_RS08255	COG0577	efflux transmembrane transporter activity
HTY60_RS08260	COG1349	DNA-binding transcription factor activity
HTY60_RS08265	COG1105	Belongs to the carbohydrate kinase PfkB family
HTY60_RS08270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HTY60_RS08270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HTY60_RS08270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HTY60_RS08275	COG0681	Belongs to the peptidase S26 family
HTY60_RS08285	COG0488	(ABC) transporter
HTY60_RS08290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HTY60_RS08295	COG2309	aminopeptidase activity
HTY60_RS08305	COG1077	Cell shape determining protein MreB Mrl
HTY60_RS08310	COG2002	toxin-antitoxin pair type II binding
HTY60_RS08315	COG3852	Histidine kinase
HTY60_RS08320	COG2105	PFAM AIG2 family protein
HTY60_RS08320	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HTY60_RS08325	COG0569	domain protein
HTY60_RS08335	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HTY60_RS08345	COG0561	phosphatase activity
HTY60_RS08350	COG0242	peptide deformylase activity
HTY60_RS08360	COG0497	DNA recombination
HTY60_RS08365	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HTY60_RS08370	COG0022	dehydrogenase e1 component
HTY60_RS08375	COG0508	dehydrogenase complex catalyzes the overall conversion of
HTY60_RS08380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HTY60_RS08385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTY60_RS08400	COG1982	Orn Lys Arg decarboxylase major
HTY60_RS08420	COG0483	inositol monophosphate 1-phosphatase activity
HTY60_RS08430	COG3227	Zinc metalloprotease (Elastase)
HTY60_RS08460	COG4896	Protein conserved in bacteria
HTY60_RS08470	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HTY60_RS08475	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HTY60_RS08480	COG2066	Belongs to the glutaminase family
HTY60_RS08490	COG0772	Belongs to the SEDS family
HTY60_RS08495	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HTY60_RS08510	COG2010	Cytochrome c
HTY60_RS08510	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HTY60_RS08515	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HTY60_RS08520	COG1845	cytochrome c oxidase, subunit III
HTY60_RS08525	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HTY60_RS08530	COG3336	cytochrome c oxidase
HTY60_RS08540	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HTY60_RS08545	COG2340	Cysteine-rich secretory protein family
HTY60_RS08560	COG3679	Belongs to the UPF0342 family
HTY60_RS08570	COG0742	ribosomal rna small subunit methyltransferase
HTY60_RS08580	COG3314	Sporulation integral membrane protein YlbJ
HTY60_RS08585	COG1752	Esterase of the alpha-beta hydrolase superfamily
HTY60_RS08590	COG3480	Lon protease (S16) C-terminal proteolytic domain
HTY60_RS08600	COG1399	metal-binding, possibly nucleic acid-binding protein
HTY60_RS08640	COG4839	cell division protein FtsL
HTY60_RS08650	COG0768	penicillin binding
HTY60_RS08670	COG0772	Belongs to the SEDS family
HTY60_RS08685	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HTY60_RS08690	COG0849	cell division
HTY60_RS08695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HTY60_RS08700	COG4412	M6 family metalloprotease domain protein
HTY60_RS08700	COG1404	Belongs to the peptidase S8 family
HTY60_RS08710	COG1191	sigma factor activity
HTY60_RS08715	COG1191	sigma factor activity
HTY60_RS08720	COG1119	ATPase activity
HTY60_RS08725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HTY60_RS08730	COG1873	PFAM PRC-barrel domain
HTY60_RS08740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HTY60_RS08750	COG0762	integral membrane protein
HTY60_RS08755	COG2302	S4 RNA-binding domain
HTY60_RS08760	COG3599	regulation of cell shape
HTY60_RS08765	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HTY60_RS08770	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HTY60_RS08780	COG0564	pseudouridine synthase activity
HTY60_RS08790	COG2233	PERMEase
HTY60_RS08800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HTY60_RS08805	COG0505	Belongs to the CarA family
HTY60_RS08810	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HTY60_RS08825	COG0284	orotidine-5'-phosphate decarboxylase activity
HTY60_RS08830	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HTY60_RS08840	COG0306	phosphate transporter
HTY60_RS08855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HTY60_RS08860	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HTY60_RS08865	COG1648	precorrin-2 dehydrogenase activity
HTY60_RS08875	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HTY60_RS08880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HTY60_RS08885	COG1561	YicC-like family, N-terminal region
HTY60_RS08895	COG0194	GDP metabolic process
HTY60_RS08905	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HTY60_RS08910	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HTY60_RS08915	COG0242	peptide deformylase activity
HTY60_RS08925	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HTY60_RS08925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HTY60_RS08935	COG0631	protein serine/threonine phosphatase activity
HTY60_RS08940	COG2815	serine threonine protein kinase
HTY60_RS08940	COG0515	serine threonine protein kinase
HTY60_RS08950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HTY60_RS08955	COG1564	THIamine pyrophosphokinase
HTY60_RS08970	COG1302	Protein conserved in bacteria
HTY60_RS08975	COG1461	Dihydroxyacetone kinase
HTY60_RS08980	COG1760	l-serine dehydratase
HTY60_RS08985	COG1760	l-serine dehydratase
HTY60_RS08990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HTY60_RS09005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HTY60_RS09010	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS09025	COG1196	nuclear chromosome segregation
HTY60_RS09030	COG0552	protein localization to endoplasmic reticulum
HTY60_RS09040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HTY60_RS09050	COG1837	Belongs to the UPF0109 family
HTY60_RS09075	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HTY60_RS09090	COG2257	FlhB HrpN YscU SpaS Family
HTY60_RS09100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HTY60_RS09105	COG0758	DNA mediated transformation
HTY60_RS09110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HTY60_RS09120	COG4974	Belongs to the 'phage' integrase family
HTY60_RS09140	COG1815	bacterial-type flagellum-dependent cell motility
HTY60_RS09145	COG1558	bacterial-type flagellum-dependent cell motility
HTY60_RS09150	COG1677	Flagellar hook-basal body complex protein FliE
HTY60_RS09155	COG1766	The M ring may be actively involved in energy transduction
HTY60_RS09160	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HTY60_RS09165	COG1317	bacterial-type flagellum organization
HTY60_RS09170	COG1157	protein secretion by the type III secretion system
HTY60_RS09175	COG2882	bacterial-type flagellum organization
HTY60_RS09180	COG3334	PFAM MgtE intracellular
HTY60_RS09185	COG3144	bacterial-type flagellum assembly
HTY60_RS09190	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HTY60_RS09195	COG4786	Flagellar basal body rod
HTY60_RS09200	COG1582	Flagellar protein (FlbD)
HTY60_RS09205	COG1580	Controls the rotational direction of flagella during chemotaxis
HTY60_RS09210	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HTY60_RS09215	COG1776	CheC inhibitor of MCP methylation
HTY60_RS09215	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HTY60_RS09220	COG2201	protein-glutamate methylesterase activity
HTY60_RS09225	COG3190	flagellar
HTY60_RS09230	COG1338	Plays a role in the flagellum-specific transport system
HTY60_RS09235	COG1987	bacterial-type flagellum assembly
HTY60_RS09240	COG1684	flagellar biosynthetic protein fliR
HTY60_RS09245	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HTY60_RS09250	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HTY60_RS09255	COG1419	protein localization to endoplasmic reticulum
HTY60_RS09260	COG0455	bacterial-type flagellum organization
HTY60_RS09270	COG2198	Histidine kinase
HTY60_RS09270	COG0643	Histidine kinase
HTY60_RS09275	COG0835	chemotaxis
HTY60_RS09280	COG1776	CheC inhibitor of MCP methylation
HTY60_RS09290	COG1191	sigma factor activity
HTY60_RS09320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HTY60_RS09325	COG4589	Belongs to the CDS family
HTY60_RS09335	COG0750	zinc metalloprotease
HTY60_RS09345	COG2176	DNA-directed DNA polymerase activity
HTY60_RS09355	COG0195	Participates in both transcription termination and antitermination
HTY60_RS09360	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HTY60_RS09365	COG1358	cellular component organization or biogenesis
HTY60_RS09375	COG1550	Protein conserved in bacteria
HTY60_RS09390	COG0196	riboflavin kinase activity
HTY60_RS09405	COG0726	polysaccharide deacetylase
HTY60_RS09410	COG0612	Peptidase, M16
HTY60_RS09415	COG1873	PFAM PRC-barrel domain
HTY60_RS09420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HTY60_RS09425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HTY60_RS09430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HTY60_RS09435	COG0527	aspartate kinase activity
HTY60_RS09445	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HTY60_RS09450	COG0740	serine-type endopeptidase activity
HTY60_RS09460	COG4980	gas vesicle protein
HTY60_RS09460	COG1674	ftsk spoiiie
HTY60_RS09465	COG2188	Transcriptional regulator
HTY60_RS09470	COG2814	Major facilitator Superfamily
HTY60_RS09475	COG1846	Transcriptional regulator
HTY60_RS09480	COG2409	Drug exporters of the RND superfamily
HTY60_RS09480	COG1033	growth of symbiont in host cell
HTY60_RS09485	COG0612	Peptidase, M16
HTY60_RS09490	COG0612	Peptidase, M16
HTY60_RS09495	COG0300	oxidoreductase activity
HTY60_RS09510	COG1426	Protein conserved in bacteria
HTY60_RS09515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HTY60_RS09530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HTY60_RS09540	COG1692	metallophosphoesterase
HTY60_RS09545	COG2359	stage V sporulation protein S
HTY60_RS09565	COG4550	Control of competence regulator ComK, YlbF/YmcA
HTY60_RS09605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HTY60_RS09610	COG3425	synthase
HTY60_RS09615	COG1024	Enoyl-CoA hydratase
HTY60_RS09620	COG1024	Enoyl-CoA hydratase
HTY60_RS09625	COG0318	PFAM AMP-dependent synthetase and ligase
HTY60_RS09625	COG3321	synthase
HTY60_RS09625	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS09625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HTY60_RS09625	COG0300	oxidoreductase activity
HTY60_RS09630	COG4221	oxidoreductase activity
HTY60_RS09630	COG0300	oxidoreductase activity
HTY60_RS09630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HTY60_RS09630	COG3321	synthase
HTY60_RS09640	COG4221	oxidoreductase activity
HTY60_RS09640	COG3321	synthase
HTY60_RS09640	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS09640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HTY60_RS09645	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HTY60_RS09645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HTY60_RS09645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HTY60_RS09645	COG3321	synthase
HTY60_RS09650	COG2124	cytochrome p450
HTY60_RS09655	COG3209	COG3209 Rhs family protein
HTY60_RS09660	COG3619	membrane
HTY60_RS09670	COG1404	Belongs to the peptidase S8 family
HTY60_RS09680	COG4195	phage-related replication protein
HTY60_RS09685	COG1764	response to oxidative stress
HTY60_RS09695	COG2076	Multidrug Resistance protein
HTY60_RS09735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HTY60_RS09740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HTY60_RS09745	COG4112	unkown
HTY60_RS09755	COG0464	growth
HTY60_RS09760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HTY60_RS09765	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HTY60_RS09770	COG0789	Transcriptional regulator
HTY60_RS09775	COG0174	glutamine synthetase
HTY60_RS09780	COG0582	viral genome integration into host DNA
HTY60_RS09790	COG1525	nuclease
HTY60_RS09795	COG4282	regulation of fungal-type cell wall biogenesis
HTY60_RS09805	COG5444	nuclease activity
HTY60_RS09835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HTY60_RS09845	COG2226	methyltransferase
HTY60_RS09865	COG3848	Pyruvate phosphate dikinase
HTY60_RS09865	COG0574	Belongs to the PEP-utilizing enzyme family
HTY60_RS09875	COG1063	alcohol dehydrogenase
HTY60_RS09885	COG0457	Tetratricopeptide repeat
HTY60_RS09925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HTY60_RS09940	COG2323	membrane
HTY60_RS09950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HTY60_RS09955	COG2323	membrane
HTY60_RS09965	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HTY60_RS09970	COG0300	oxidoreductase activity
HTY60_RS09985	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HTY60_RS09990	COG0583	DNA-binding transcription factor activity
HTY60_RS09995	COG0067	glutamate synthase
HTY60_RS09995	COG0069	glutamate synthase activity
HTY60_RS09995	COG0070	glutamate synthase
HTY60_RS10000	COG0493	'glutamate synthase
HTY60_RS10005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HTY60_RS10010	COG0640	Transcriptional regulator
HTY60_RS10015	COG2814	Major facilitator Superfamily
HTY60_RS10020	COG0405	Gamma-glutamyltransferase
HTY60_RS10025	COG0166	Belongs to the GPI family
HTY60_RS10030	COG0582	viral genome integration into host DNA
HTY60_RS10045	COG0534	Mate efflux family protein
HTY60_RS10050	COG2017	converts alpha-aldose to the beta-anomer
HTY60_RS10055	COG2027	D-alanyl-D-alanine carboxypeptidase
HTY60_RS10060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HTY60_RS10065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HTY60_RS10065	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HTY60_RS10075	COG1649	PFAM Uncharacterised BCR, COG1649
HTY60_RS10080	COG1960	acyl-CoA dehydrogenase activity
HTY60_RS10090	COG0439	Biotin carboxylase
HTY60_RS10095	COG0511	ligase activity, forming carbon-carbon bonds
HTY60_RS10100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HTY60_RS10105	COG1024	Enoyl-CoA hydratase
HTY60_RS10110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HTY60_RS10115	COG0586	Pfam SNARE associated Golgi protein
HTY60_RS10120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HTY60_RS10125	COG2246	polysaccharide biosynthetic process
HTY60_RS10135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HTY60_RS10160	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HTY60_RS10165	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HTY60_RS10170	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS10195	COG3507	Belongs to the glycosyl hydrolase 43 family
HTY60_RS10205	COG0745	RESPONSE REGULATOR receiver
HTY60_RS10210	COG2205	protein histidine kinase activity
HTY60_RS10240	COG1115	amino acid carrier protein
HTY60_RS10250	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HTY60_RS10255	COG0187	DNA topoisomerase II activity
HTY60_RS10260	COG1832	CoA-binding protein
HTY60_RS10270	COG4841	protein insertion into membrane
HTY60_RS10280	COG0824	Thioesterase
HTY60_RS10300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTY60_RS10305	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HTY60_RS10320	COG0071	Belongs to the small heat shock protein (HSP20) family
HTY60_RS10330	COG4846	Membrane protein involved in cytochrome C biogenesis
HTY60_RS10335	COG2201	protein-glutamate methylesterase activity
HTY60_RS10340	COG0785	Cytochrome C biogenesis protein
HTY60_RS10360	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HTY60_RS10370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HTY60_RS10405	COG4195	phage-related replication protein
HTY60_RS10415	COG0756	dUTP diphosphatase activity
HTY60_RS10420	COG2314	TM2 domain
HTY60_RS10425	COG5434	Belongs to the glycosyl hydrolase 28 family
HTY60_RS10445	COG3397	chitin binding
HTY60_RS10480	COG0456	acetyltransferase
HTY60_RS10500	COG1064	alcohol dehydrogenase
HTY60_RS10505	COG2318	DinB family
HTY60_RS10515	COG2323	membrane
HTY60_RS10520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HTY60_RS10530	COG2323	membrane
HTY60_RS10545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HTY60_RS10585	COG2814	Major facilitator Superfamily
HTY60_RS10590	COG1070	Carbohydrate kinase
HTY60_RS10600	COG0243	molybdopterin cofactor binding
HTY60_RS10630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HTY60_RS10635	COG0662	Cupin 2, conserved barrel domain protein
HTY60_RS10635	COG2207	Transcriptional regulator
HTY60_RS10640	COG1309	transcriptional regulator
HTY60_RS10645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HTY60_RS10655	COG0640	Transcriptional regulator
HTY60_RS10660	COG0741	lytic transglycosylase activity
HTY60_RS10665	COG2322	membrane
HTY60_RS10680	COG1619	proteins homologs of microcin C7 resistance protein MccF
HTY60_RS10690	COG1388	LysM domain
HTY60_RS10690	COG3584	3D domain protein
HTY60_RS10695	COG0514	ATP-dependent DNA helicase (RecQ)
HTY60_RS10705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HTY60_RS10710	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HTY60_RS10725	COG0071	Belongs to the small heat shock protein (HSP20) family
HTY60_RS10755	COG1012	belongs to the aldehyde dehydrogenase family
HTY60_RS10760	COG1657	PFAM Prenyltransferase squalene oxidase
HTY60_RS10765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HTY60_RS10770	COG0733	neurotransmitter:sodium symporter activity
HTY60_RS10775	COG0385	Bile acid
HTY60_RS10780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HTY60_RS10785	COG0508	dehydrogenase complex catalyzes the overall conversion of
HTY60_RS10795	COG4548	von Willebrand factor, type A
HTY60_RS10800	COG0714	Associated with various cellular activities
HTY60_RS10805	COG2032	superoxide dismutase activity
HTY60_RS10815	COG1819	glycosyl
HTY60_RS10820	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HTY60_RS10825	COG0534	Mate efflux family protein
HTY60_RS10830	COG1366	Belongs to the anti-sigma-factor antagonist family
HTY60_RS10835	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HTY60_RS10840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HTY60_RS10850	COG2962	Rard protein
HTY60_RS10865	COG1942	4-Oxalocrotonate Tautomerase
HTY60_RS10870	COG1733	regulation of RNA biosynthetic process
HTY60_RS10875	COG0778	Nitroreductase
HTY60_RS10885	COG0346	lactoylglutathione lyase activity
HTY60_RS10895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HTY60_RS10905	COG2723	6-phospho-beta-galactosidase activity
HTY60_RS10910	COG2188	Transcriptional regulator
HTY60_RS10915	COG0793	Belongs to the peptidase S41A family
HTY60_RS10915	COG3409	Peptidoglycan-binding domain 1 protein
HTY60_RS10930	COG1876	peptidase activity
HTY60_RS10950	COG0671	phosphoesterase, PA-phosphatase related
HTY60_RS10970	COG0346	lactoylglutathione lyase activity
HTY60_RS10985	COG1509	lysine 2,3-aminomutase activity
HTY60_RS10990	COG0456	acetyltransferase
HTY60_RS10995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HTY60_RS11000	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HTY60_RS11005	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HTY60_RS11010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HTY60_RS11015	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HTY60_RS11025	COG0456	acetyltransferase
HTY60_RS11030	COG0463	Glycosyl transferase, family 2
HTY60_RS11045	COG4641	Protein conserved in bacteria
HTY60_RS11055	COG1086	Polysaccharide biosynthesis protein
HTY60_RS11080	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HTY60_RS11085	COG1086	Polysaccharide biosynthesis protein
HTY60_RS11100	COG1846	Transcriptional regulator
HTY60_RS11105	COG4698	Protein conserved in bacteria
HTY60_RS11110	COG2755	lipolytic protein G-D-S-L family
HTY60_RS11115	COG1999	signal sequence binding
HTY60_RS11125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HTY60_RS11130	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HTY60_RS11135	COG1272	protein, Hemolysin III
HTY60_RS11140	COG0204	Acyl-transferase
HTY60_RS11145	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HTY60_RS11150	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HTY60_RS11160	COG2136	Putative SAM-dependent methyltransferase
HTY60_RS11160	COG2521	methyltransferase
HTY60_RS11175	COG1413	lyase activity
HTY60_RS11180	COG1418	mRNA catabolic process
HTY60_RS11185	COG0386	Belongs to the glutathione peroxidase family
HTY60_RS11195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HTY60_RS11205	COG1278	Cold shock
HTY60_RS11225	COG0328	RNA-DNA hybrid ribonuclease activity
HTY60_RS11230	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HTY60_RS11235	COG0328	RNA-DNA hybrid ribonuclease activity
HTY60_RS11245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HTY60_RS11260	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HTY60_RS11270	COG1755	Isoprenylcysteine carboxyl methyltransferase
HTY60_RS11275	COG3424	synthase
HTY60_RS11295	COG2233	PERMEase
HTY60_RS11310	COG1199	ATP-dependent helicase activity
HTY60_RS11330	COG0116	Belongs to the methyltransferase superfamily
HTY60_RS11360	COG3359	exonuclease
HTY60_RS11365	COG1205	dead DEAH box helicase
HTY60_RS11365	COG1111	helicase
HTY60_RS11370	COG2190	(PTS) system
HTY60_RS11375	COG0071	Belongs to the small heat shock protein (HSP20) family
HTY60_RS11415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HTY60_RS11415	COG4499	WXG100 protein secretion system (Wss), protein YukC
HTY60_RS11425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HTY60_RS11430	COG3935	DnaD domain protein
HTY60_RS11440	COG0436	Aminotransferase
HTY60_RS11445	COG5353	protein conserved in bacteria
HTY60_RS11455	COG1199	ATP-dependent helicase activity
HTY60_RS11455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HTY60_RS11485	COG0438	transferase activity, transferring glycosyl groups
HTY60_RS11490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HTY60_RS11505	COG1694	Mazg nucleotide pyrophosphohydrolase
HTY60_RS11510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HTY60_RS11515	COG2140	Oxalate decarboxylase
HTY60_RS11525	COG4347	Protein of unknown function (DUF1405)
HTY60_RS11530	COG2010	Cytochrome c
HTY60_RS11530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HTY60_RS11535	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HTY60_RS11540	COG0723	plastoquinol--plastocyanin reductase activity
HTY60_RS11555	COG0457	Tetratricopeptide repeat
HTY60_RS11565	COG0287	Prephenate dehydrogenase
HTY60_RS11600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HTY60_RS11605	COG4401	Chorismate mutase type I
HTY60_RS11620	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HTY60_RS11625	COG0105	UTP biosynthetic process
HTY60_RS11630	COG0142	geranyltranstransferase activity
HTY60_RS11640	COG0142	geranyltranstransferase activity
HTY60_RS11655	COG0776	regulation of translation
HTY60_RS11660	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HTY60_RS11700	COG0539	negative regulation of cytoplasmic translation
HTY60_RS11715	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HTY60_RS11720	COG2959	enzyme of heme biosynthesis
HTY60_RS11725	COG3409	Peptidoglycan-binding domain 1 protein
HTY60_RS11725	COG3773	Cell wall hydrolase
HTY60_RS11730	COG2339	peptidase activity
HTY60_RS11735	COG0492	ferredoxin-NADP+ reductase activity
HTY60_RS11740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HTY60_RS11745	COG4862	establishment of competence for transformation
HTY60_RS11750	COG1408	metallophosphoesterase
HTY60_RS11760	COG1388	LysM domain
HTY60_RS11765	COG1266	CAAX protease self-immunity
HTY60_RS11770	COG0514	ATP-dependent DNA helicase (RecQ)
HTY60_RS11775	COG4955	Helix-turn-helix domain
HTY60_RS11780	COG1141	Ferredoxin
HTY60_RS11785	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HTY60_RS11790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HTY60_RS11800	COG1595	DNA-templated transcription, initiation
HTY60_RS11805	COG5002	protein histidine kinase activity
HTY60_RS11810	COG0745	RESPONSE REGULATOR receiver
HTY60_RS11815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HTY60_RS11820	COG1333	cytochrome c biogenesis protein
HTY60_RS11825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTY60_RS11830	COG1187	pseudouridine synthase activity
HTY60_RS11835	COG0700	Nucleoside recognition
HTY60_RS11840	COG2715	membrane protein required for spore maturation
HTY60_RS11845	COG1686	Belongs to the peptidase S11 family
HTY60_RS11870	COG1547	Domain of unknown function (DUF309)
HTY60_RS11875	COG0456	acetyltransferase
HTY60_RS11880	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HTY60_RS11885	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HTY60_RS11885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HTY60_RS11890	COG0307	riboflavin synthase, alpha
HTY60_RS11895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HTY60_RS11895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HTY60_RS11905	COG0681	Belongs to the peptidase S26 family
HTY60_RS11915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HTY60_RS11920	COG4086	secreted protein
HTY60_RS11925	COG0019	diaminopimelate decarboxylase activity
HTY60_RS11930	COG0697	spore germination
HTY60_RS11945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HTY60_RS11965	COG1191	sigma factor activity
HTY60_RS11975	COG1366	Belongs to the anti-sigma-factor antagonist family
HTY60_RS11980	COG1686	Belongs to the peptidase S11 family
HTY60_RS11985	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HTY60_RS11990	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HTY60_RS11995	COG4974	Belongs to the 'phage' integrase family
HTY60_RS12005	COG0735	belongs to the Fur family
HTY60_RS12010	COG1300	Membrane
HTY60_RS12025	COG0281	malic enzyme
HTY60_RS12030	COG1757	Na H antiporter
HTY60_RS12035	COG1027	Aspartate ammonia-lyase
HTY60_RS12040	COG0252	asparaginase activity
HTY60_RS12045	COG1396	sequence-specific DNA binding
HTY60_RS12050	COG1379	DNA repair
HTY60_RS12055	COG0494	nUDIX hydrolase
HTY60_RS12065	COG0667	Aldo Keto reductase
HTY60_RS12085	COG4918	Iron-sulphur cluster biosynthesis
HTY60_RS12090	COG0456	acetyltransferase
HTY60_RS12090	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HTY60_RS12095	COG0456	acetyltransferase
HTY60_RS12100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HTY60_RS12115	COG0628	permease
HTY60_RS12130	COG3048	D-serine ammonia-lyase activity
HTY60_RS12135	COG0300	oxidoreductase activity
HTY60_RS12140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HTY60_RS12145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HTY60_RS12165	COG0596	Alpha beta hydrolase
HTY60_RS12180	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HTY60_RS12185	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HTY60_RS12200	COG0706	membrane insertase activity
HTY60_RS12205	COG2195	Cleaves the N-terminal amino acid of tripeptides
HTY60_RS12215	COG0346	lactoylglutathione lyase activity
HTY60_RS12225	COG1376	ErfK ybiS ycfS ynhG family protein
HTY60_RS12230	COG4129	membrane
HTY60_RS12235	COG1126	abc transporter atp-binding protein
HTY60_RS12240	COG0765	amino acid transport
HTY60_RS12245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HTY60_RS12255	COG1597	lipid kinase activity
HTY60_RS12260	COG0508	dehydrogenase complex catalyzes the overall conversion of
HTY60_RS12265	COG0022	dehydrogenase e1 component
HTY60_RS12270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HTY60_RS12275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HTY60_RS12280	COG3426	butyrate kinase activity
HTY60_RS12285	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HTY60_RS12290	COG0280	phosphate acetyltransferase
HTY60_RS12295	COG3290	protein histidine kinase activity
HTY60_RS12295	COG3829	transcription factor binding
HTY60_RS12305	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HTY60_RS12310	COG2079	MmgE PrpD family protein
HTY60_RS12315	COG0372	Belongs to the citrate synthase family
HTY60_RS12320	COG1960	acyl-CoA dehydrogenase activity
HTY60_RS12330	COG0183	Belongs to the thiolase family
HTY60_RS12335	COG0584	glycerophosphoryl diester phosphodiesterase
HTY60_RS12340	COG0860	N-Acetylmuramoyl-L-alanine amidase
HTY60_RS12365	COG1902	pentaerythritol trinitrate reductase activity
HTY60_RS12380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HTY60_RS12385	COG0745	RESPONSE REGULATOR receiver
HTY60_RS12390	COG0750	zinc metalloprotease
HTY60_RS12395	COG0497	DNA recombination
HTY60_RS12405	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HTY60_RS12415	COG0142	geranyltranstransferase activity
HTY60_RS12425	COG1570	exodeoxyribonuclease VII activity
HTY60_RS12440	COG1302	Protein conserved in bacteria
HTY60_RS12445	COG0439	Biotin carboxylase
HTY60_RS12450	COG0511	ligase activity, forming carbon-carbon bonds
HTY60_RS12490	COG3854	ATPases associated with a variety of cellular activities
HTY60_RS12505	COG0006	proline dipeptidase activity
HTY60_RS12515	COG3872	metal-dependent enzyme
HTY60_RS12525	COG1752	Esterase of the alpha-beta hydrolase superfamily
HTY60_RS12540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HTY60_RS12560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HTY60_RS12575	COG1396	sequence-specific DNA binding
HTY60_RS12585	COG0681	Belongs to the peptidase S26 family
HTY60_RS12610	COG4940	Competence protein ComGF
HTY60_RS12620	COG4970	Tfp pilus assembly protein FimT
HTY60_RS12625	COG4537	Required for transformation and DNA binding
HTY60_RS12630	COG1459	type II secretion system
HTY60_RS12635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HTY60_RS12640	COG0598	Magnesium transport protein CorA
HTY60_RS12645	COG1253	flavin adenine dinucleotide binding
HTY60_RS12650	COG1366	Belongs to the anti-sigma-factor antagonist family
HTY60_RS12660	COG1393	Belongs to the ArsC family
HTY60_RS12670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HTY60_RS12680	COG0011	TIGRFAM Protein of
HTY60_RS12690	COG2866	Carboxypeptidase
HTY60_RS12695	COG1940	carbohydrate kinase activity
HTY60_RS12700	COG4483	Protein conserved in bacteria
HTY60_RS12705	COG1757	Na H antiporter
HTY60_RS12715	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HTY60_RS12730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HTY60_RS12735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HTY60_RS12740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HTY60_RS12745	COG0581	inorganic phosphate transmembrane transporter activity
HTY60_RS12750	COG0573	inorganic phosphate transmembrane transporter activity
HTY60_RS12755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HTY60_RS12765	COG0477	Major facilitator Superfamily
HTY60_RS12770	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HTY60_RS12775	COG2839	Protein conserved in bacteria
HTY60_RS12780	COG5521	maltodextrose utilization protein MalA
HTY60_RS12785	COG1388	LysM domain
HTY60_RS12795	COG4709	membrane
HTY60_RS12800	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HTY60_RS12805	COG0735	belongs to the Fur family
HTY60_RS12810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HTY60_RS12825	COG0513	Belongs to the DEAD box helicase family
HTY60_RS12840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HTY60_RS12845	COG2384	SAM-dependent methyltransferase
HTY60_RS12850	COG2010	Cytochrome c
HTY60_RS12855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HTY60_RS12860	COG0358	DNA primase activity
HTY60_RS12875	COG0517	IMP dehydrogenase activity
HTY60_RS12880	COG0751	glycine-tRNA ligase activity
HTY60_RS12900	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HTY60_RS12905	COG0295	cytidine deaminase activity
HTY60_RS12910	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HTY60_RS12925	COG1702	phosphate starvation-inducible protein PhoH
HTY60_RS12930	COG0561	phosphatase activity
HTY60_RS12945	COG4864	UPF0365 protein
HTY60_RS12950	COG1030	water channel activity
HTY60_RS12955	COG1610	YqeY-like protein
HTY60_RS12965	COG1283	sodium-dependent phosphate transmembrane transporter activity
HTY60_RS12970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HTY60_RS12975	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HTY60_RS13005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HTY60_RS13020	COG0860	N-Acetylmuramoyl-L-alanine amidase
HTY60_RS13035	COG1466	dna polymerase III delta subunit
HTY60_RS13050	COG2333	competence protein COMEC
HTY60_RS13050	COG0658	competence protein
HTY60_RS13055	COG2131	deaminase
HTY60_RS13060	COG1555	photosystem II stabilization
HTY60_RS13060	COG1596	polysaccharide export
HTY60_RS13065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HTY60_RS13070	COG2226	methyltransferase
HTY60_RS13075	COG0799	negative regulation of ribosome biogenesis
HTY60_RS13080	COG1713	HD superfamily hydrolase involved in NAD metabolism
HTY60_RS13090	COG1534	Rna-binding protein
HTY60_RS13095	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HTY60_RS13100	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HTY60_RS13105	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HTY60_RS13115	COG2755	lipolytic protein G-D-S-L family
HTY60_RS13125	COG0398	Pfam SNARE associated Golgi protein
HTY60_RS13175	COG0512	Glutamine amidotransferase of anthranilate synthase
HTY60_RS13200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HTY60_RS13215	COG2378	regulation of single-species biofilm formation
HTY60_RS13220	COG0693	protein deglycase activity
HTY60_RS13260	COG1794	racemase activity, acting on amino acids and derivatives
HTY60_RS13275	COG1733	regulation of RNA biosynthetic process
HTY60_RS13280	COG0656	L-ascorbic acid biosynthetic process
HTY60_RS13315	COG0563	adenylate kinase activity
HTY60_RS13320	COG2814	Major facilitator Superfamily
HTY60_RS13330	COG0456	acetyltransferase
HTY60_RS13335	COG2318	DinB family
HTY60_RS13345	COG0561	phosphatase activity
HTY60_RS13360	COG1482	cell wall glycoprotein biosynthetic process
HTY60_RS13365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HTY60_RS13365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HTY60_RS13365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HTY60_RS13370	COG3711	transcriptional antiterminator
HTY60_RS13370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HTY60_RS13380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HTY60_RS13385	COG0583	DNA-binding transcription factor activity
HTY60_RS13390	COG2814	Major facilitator Superfamily
HTY60_RS13395	COG2124	cytochrome p450
HTY60_RS13395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HTY60_RS13400	COG1309	transcriptional regulator
HTY60_RS13405	COG2226	methyltransferase
HTY60_RS13420	COG2116	formate transmembrane transporter activity
HTY60_RS13425	COG5609	conserved protein (DUF2294)
HTY60_RS13430	COG3383	formate dehydrogenase (NAD+) activity
HTY60_RS13435	COG2427	Protein of unknown function (DUF1641)
HTY60_RS13445	COG0626	cystathionine gamma-synthase activity
HTY60_RS13450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HTY60_RS13475	COG0768	penicillin binding
HTY60_RS13500	COG4122	O-methyltransferase activity
HTY60_RS13505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HTY60_RS13530	COG0628	permease
HTY60_RS13535	COG1126	abc transporter atp-binding protein
HTY60_RS13540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HTY60_RS13545	COG0765	amino acid transport
HTY60_RS13550	COG0765	amino acid transport
HTY60_RS13565	COG3881	PFAM PRC-barrel domain
HTY60_RS13570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HTY60_RS13575	COG0457	Tetratricopeptide repeat
HTY60_RS13585	COG1104	cysteine desulfurase activity
HTY60_RS13590	COG1959	2 iron, 2 sulfur cluster binding
HTY60_RS13595	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HTY60_RS13600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HTY60_RS13625	COG0860	N-Acetylmuramoyl-L-alanine amidase
HTY60_RS13625	COG3103	Sh3 type 3 domain protein
HTY60_RS13625	COG4991	sh3 domain protein
HTY60_RS13630	COG1490	D-aminoacyl-tRNA deacylase activity
HTY60_RS13635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HTY60_RS13645	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HTY60_RS13645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HTY60_RS13650	COG5416	Lipopolysaccharide assembly protein A domain
HTY60_RS13655	COG0490	domain, Protein
HTY60_RS13660	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HTY60_RS13660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HTY60_RS13670	COG2244	polysaccharide biosynthetic process
HTY60_RS13675	COG2323	membrane
HTY60_RS13685	COG1862	Preprotein translocase
HTY60_RS13725	COG1388	LysM domain
HTY60_RS13735	COG0157	Belongs to the NadC ModD family
HTY60_RS13740	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HTY60_RS13745	COG1104	cysteine desulfurase activity
HTY60_RS13750	COG1827	regulation of RNA biosynthetic process
HTY60_RS13755	COG0077	Prephenate dehydratase
HTY60_RS13770	COG3290	protein histidine kinase activity
HTY60_RS13775	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HTY60_RS13780	COG2868	ribosomal protein
HTY60_RS13790	COG1994	Peptidase M50
HTY60_RS13795	COG0739	heme binding
HTY60_RS13800	COG2894	cell division
HTY60_RS13805	COG0850	regulation of cytokinetic process
HTY60_RS13810	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HTY60_RS13820	COG1077	Cell shape determining protein MreB Mrl
HTY60_RS13840	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HTY60_RS13845	COG0285	dihydrofolate synthase activity
HTY60_RS13850	COG0525	valine-tRNA ligase activity
HTY60_RS13860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HTY60_RS13865	COG1388	LysM domain
HTY60_RS13875	COG0113	porphobilinogen synthase activity
HTY60_RS13880	COG1587	Uroporphyrinogen-III synthase
HTY60_RS13890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HTY60_RS13910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HTY60_RS13915	COG1067	ATP-dependent peptidase activity
HTY60_RS13915	COG0470	DNA polymerase III
HTY60_RS13930	COG0457	Tetratricopeptide repeat
HTY60_RS13930	COG1477	protein flavinylation
HTY60_RS13945	COG0473	3-isopropylmalate dehydrogenase activity
HTY60_RS13960	COG0440	acetolactate synthase activity
HTY60_RS13965	COG0028	Belongs to the TPP enzyme family
HTY60_RS13990	COG0622	Phosphoesterase
HTY60_RS13995	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HTY60_RS14005	COG5401	PFAM Sporulation and spore germination
HTY60_RS14015	COG1846	Transcriptional regulator
HTY60_RS14020	COG2197	response regulator
HTY60_RS14025	COG0824	Thioesterase
HTY60_RS14030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HTY60_RS14035	COG1053	succinate dehydrogenase
HTY60_RS14040	COG2009	succinate dehydrogenase
HTY60_RS14045	COG1719	4-vinyl reductase, 4VR
HTY60_RS14050	COG0527	aspartate kinase activity
HTY60_RS14060	COG3118	belongs to the thioredoxin family
HTY60_RS14065	COG3534	alpha-L-arabinofuranosidase
HTY60_RS14070	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HTY60_RS14075	COG2086	electron transfer activity
HTY60_RS14080	COG1024	Enoyl-CoA hydratase
HTY60_RS14085	COG1309	transcriptional regulator
HTY60_RS14090	COG0318	PFAM AMP-dependent synthetase and ligase
HTY60_RS14100	COG3766	membrane
HTY60_RS14110	COG1796	DNA polymerase
HTY60_RS14110	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HTY60_RS14115	COG1286	toxin biosynthetic process
HTY60_RS14130	COG0072	phenylalanine-tRNA ligase activity
HTY60_RS14130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HTY60_RS14135	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HTY60_RS14140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HTY60_RS14150	COG3835	regulator
HTY60_RS14155	COG0277	FAD linked oxidase domain protein
HTY60_RS14160	COG0247	lactate metabolic process
HTY60_RS14165	COG1966	Carbon starvation protein
HTY60_RS14170	COG3534	alpha-L-arabinofuranosidase
HTY60_RS14175	COG0395	ABC-type sugar transport system, permease component
HTY60_RS14180	COG1175	transmembrane transport
HTY60_RS14185	COG1653	transport
HTY60_RS14195	COG0647	UMP catabolic process
HTY60_RS14200	COG0235	Class ii aldolase
HTY60_RS14205	COG1069	ribulokinase activity
HTY60_RS14210	COG2160	L-arabinose isomerase activity
HTY60_RS14215	COG3507	Belongs to the glycosyl hydrolase 43 family
HTY60_RS14220	COG1363	Peptidase, m42
HTY60_RS14230	COG3326	Membrane
HTY60_RS14235	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HTY60_RS14245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HTY60_RS14250	COG1346	cytolysis
HTY60_RS14255	COG1380	Effector of murein hydrolase LrgA
HTY60_RS14260	COG3279	Response regulator of the LytR AlgR family
HTY60_RS14265	COG3275	phosphorelay sensor kinase activity
HTY60_RS14270	COG1011	Hydrolase
HTY60_RS14285	COG0398	Pfam SNARE associated Golgi protein
HTY60_RS14290	COG1484	DNA-dependent DNA replication
HTY60_RS14295	COG3611	Membrane attachment protein
HTY60_RS14310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HTY60_RS14315	COG1733	regulation of RNA biosynthetic process
HTY60_RS14320	COG2814	Major facilitator Superfamily
HTY60_RS14325	COG0656	L-ascorbic acid biosynthetic process
HTY60_RS14330	COG0237	dephospho-CoA kinase activity
HTY60_RS14335	COG1971	Probably functions as a manganese efflux pump
HTY60_RS14340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HTY60_RS14345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HTY60_RS14345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HTY60_RS14350	COG5002	protein histidine kinase activity
HTY60_RS14355	COG0745	RESPONSE REGULATOR receiver
HTY60_RS14365	COG0538	isocitrate dehydrogenase activity
HTY60_RS14370	COG0372	Belongs to the citrate synthase family
HTY60_RS14380	COG0628	permease
HTY60_RS14385	COG3030	protein affecting phage T7 exclusion by the F plasmid
HTY60_RS14390	COG0469	pyruvate kinase activity
HTY60_RS14410	COG0281	malic enzyme
HTY60_RS14415	COG0587	DNA-directed DNA polymerase activity
HTY60_RS14435	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HTY60_RS14445	COG4109	DRTGG domain
HTY60_RS14455	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS14470	COG0521	Mo-molybdopterin cofactor biosynthetic process
HTY60_RS14480	COG0827	DNA restriction-modification system
HTY60_RS14485	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HTY60_RS14490	COG3874	Sporulation protein YtfJ
HTY60_RS14500	COG1714	RDD family
HTY60_RS14505	COG0616	signal peptide processing
HTY60_RS14510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HTY60_RS14515	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HTY60_RS14520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HTY60_RS14535	COG1104	cysteine desulfurase activity
HTY60_RS14540	COG1114	Component of the transport system for branched-chain amino acids
HTY60_RS14550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HTY60_RS14555	COG1309	transcriptional regulator
HTY60_RS14560	COG1956	GAF domain-containing protein
HTY60_RS14565	COG2203	Gaf domain
HTY60_RS14565	COG2199	diguanylate cyclase activity
HTY60_RS14575	COG1017	nitric oxide dioxygenase activity
HTY60_RS14575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HTY60_RS14600	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HTY60_RS14605	COG1378	Sugar-specific transcriptional regulator TrmB
HTY60_RS14610	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HTY60_RS14625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HTY60_RS14630	COG0454	-acetyltransferase
HTY60_RS14635	COG0517	IMP dehydrogenase activity
HTY60_RS14640	COG0123	including yeast histone deacetylase and acetoin utilization protein
HTY60_RS14645	COG1360	Flagellar Motor Protein
HTY60_RS14650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HTY60_RS14655	COG1609	Transcriptional regulator
HTY60_RS14660	COG1605	Chorismate mutase
HTY60_RS14660	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HTY60_RS14665	COG3118	belongs to the thioredoxin family
HTY60_RS14670	COG4980	gas vesicle protein
HTY60_RS14675	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HTY60_RS14685	COG1674	ftsk spoiiie
HTY60_RS14690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HTY60_RS14700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTY60_RS14710	COG1363	Peptidase, m42
HTY60_RS14715	COG5584	Small secreted protein
HTY60_RS14725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HTY60_RS14740	COG0510	thiamine kinase activity
HTY60_RS14745	COG1597	lipid kinase activity
HTY60_RS14755	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HTY60_RS14760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HTY60_RS14765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HTY60_RS14770	COG2252	PERMEase
HTY60_RS14775	COG4473	ABC transporter
HTY60_RS14780	COG1131	(ABC) transporter
HTY60_RS14785	COG1349	DNA-binding transcription factor activity
HTY60_RS14790	COG1187	pseudouridine synthase activity
HTY60_RS14795	COG2244	polysaccharide biosynthetic process
HTY60_RS14800	COG2081	HI0933 family
HTY60_RS14805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HTY60_RS14815	COG1609	Transcriptional regulator
HTY60_RS14820	COG1653	transport
HTY60_RS14825	COG1175	transmembrane transport
HTY60_RS14830	COG0395	ABC-type sugar transport system, permease component
HTY60_RS14835	COG1486	melibiose metabolic process
HTY60_RS14845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HTY60_RS14860	COG2202	Pas domain
HTY60_RS14860	COG1366	Belongs to the anti-sigma-factor antagonist family
HTY60_RS14865	COG2814	Major facilitator Superfamily
HTY60_RS14875	COG0577	efflux transmembrane transporter activity
HTY60_RS14880	COG1136	(ABC) transporter
HTY60_RS14885	COG2205	protein histidine kinase activity
HTY60_RS14890	COG0745	RESPONSE REGULATOR receiver
HTY60_RS14895	COG0577	efflux transmembrane transporter activity
HTY60_RS14900	COG1136	(ABC) transporter
HTY60_RS14920	COG1131	(ABC) transporter
HTY60_RS14940	COG1242	4 iron, 4 sulfur cluster binding
HTY60_RS14945	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HTY60_RS14960	COG2267	carboxylic ester hydrolase activity
HTY60_RS14965	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HTY60_RS14970	COG1113	amino acid transport
HTY60_RS14975	COG0367	asparagine synthase
HTY60_RS14995	COG1506	peptidase
HTY60_RS15000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HTY60_RS15005	COG1116	anion transmembrane transporter activity
HTY60_RS15010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HTY60_RS15015	COG0494	nUDIX hydrolase
HTY60_RS15020	COG4824	toxin secretion phage lysis holin
HTY60_RS15025	COG0783	Belongs to the Dps family
HTY60_RS15050	COG0288	reversible hydration of carbon dioxide
HTY60_RS15060	COG1271	oxidase subunit
HTY60_RS15065	COG1294	oxidase, subunit
HTY60_RS15075	COG4948	Mandelate Racemase Muconate Lactonizing
HTY60_RS15085	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HTY60_RS15090	COG0596	Alpha beta hydrolase
HTY60_RS15100	COG1169	isochorismate synthase
HTY60_RS15105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HTY60_RS15110	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HTY60_RS15235	COG3859	Proton-coupled thiamine transporter YuaJ
HTY60_RS15240	COG2268	Band 7 protein
HTY60_RS15245	COG1585	Membrane protein implicated in regulation of membrane protease activity
HTY60_RS15250	COG2318	DinB family
HTY60_RS15260	COG1454	alcohol dehydrogenase
HTY60_RS15265	COG1012	belongs to the aldehyde dehydrogenase family
HTY60_RS15270	COG1510	regulation of RNA biosynthetic process
HTY60_RS15280	COG0569	domain protein
HTY60_RS15285	COG1705	Flagellar rod assembly protein muramidase FlgJ
HTY60_RS15290	COG1017	nitric oxide dioxygenase activity
HTY60_RS15290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HTY60_RS15305	COG0457	Tetratricopeptide repeat
HTY60_RS15355	COG5632	N-Acetylmuramoyl-L-alanine amidase
HTY60_RS15360	COG4824	toxin secretion phage lysis holin
HTY60_RS15380	COG5434	Belongs to the glycosyl hydrolase 28 family
HTY60_RS15395	COG5412	phage tail tape measure protein
HTY60_RS15395	COG3953	SLT domain
HTY60_RS15535	COG0582	viral genome integration into host DNA
HTY60_RS15550	COG0628	permease
HTY60_RS15555	COG0673	inositol 2-dehydrogenase activity
HTY60_RS15560	COG0693	protein deglycase activity
HTY60_RS15570	COG0840	transmembrane signaling receptor activity
HTY60_RS15575	COG0840	transmembrane signaling receptor activity
HTY60_RS15580	COG0840	transmembrane signaling receptor activity
HTY60_RS15595	COG2070	2-Nitropropane dioxygenase
HTY60_RS15605	COG0366	Alpha amylase catalytic
HTY60_RS15610	COG1253	flavin adenine dinucleotide binding
HTY60_RS15615	COG2738	Putative neutral zinc metallopeptidase
HTY60_RS15630	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HTY60_RS15650	COG1979	alcohol dehydrogenase
HTY60_RS15655	COG1979	alcohol dehydrogenase
HTY60_RS15660	COG2155	Conserved Protein
HTY60_RS15665	COG1098	S1 RNA binding domain
HTY60_RS15670	COG0436	Aminotransferase
HTY60_RS15675	COG1522	sequence-specific DNA binding
HTY60_RS15680	COG2267	carboxylic ester hydrolase activity
HTY60_RS15690	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HTY60_RS15695	COG2205	protein histidine kinase activity
HTY60_RS15705	COG5018	Exonuclease
HTY60_RS15710	COG2814	Major facilitator Superfamily
HTY60_RS15715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HTY60_RS15720	COG3011	Protein conserved in bacteria
HTY60_RS15730	COG3290	protein histidine kinase activity
HTY60_RS15735	COG4565	transcriptional regulatory protein
HTY60_RS15765	COG2111	Na H antiporter
HTY60_RS15765	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HTY60_RS15770	COG2111	Na H antiporter
HTY60_RS15775	COG1006	Multisubunit Na H antiporter MnhC subunit
HTY60_RS15780	COG0651	ATP synthesis coupled electron transport
HTY60_RS15785	COG1863	multisubunit Na H antiporter MnhE subunit
HTY60_RS15790	COG2212	antiporter activity
HTY60_RS15795	COG1320	monovalent cation:proton antiporter activity
HTY60_RS15800	COG2050	protein possibly involved in aromatic compounds catabolism
HTY60_RS15805	COG2197	response regulator
HTY60_RS15810	COG4585	Histidine kinase
HTY60_RS15820	COG0142	geranyltranstransferase activity
HTY60_RS15835	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HTY60_RS15840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HTY60_RS15845	COG1335	isochorismatase
HTY60_RS15850	COG5506	Protein of unknown function (DUF1694)
HTY60_RS15865	COG0628	permease
HTY60_RS15875	COG1418	mRNA catabolic process
HTY60_RS15880	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS15890	COG1511	domain protein
HTY60_RS15895	COG1674	ftsk spoiiie
HTY60_RS15895	COG0433	COG0433 Predicted ATPase
HTY60_RS15900	COG4499	WXG100 protein secretion system (Wss), protein YukC
HTY60_RS15905	COG5417	Belongs to the EsaB family
HTY60_RS15910	COG4842	Belongs to the WXG100 family
HTY60_RS15915	COG2508	Transcriptional regulator
HTY60_RS15915	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HTY60_RS15920	COG0686	Belongs to the AlaDH PNT family
HTY60_RS15925	COG5634	Uncharacterized conserved protein (DUF2278)
HTY60_RS15930	COG3251	PFAM MbtH domain protein
HTY60_RS15940	COG3433	isochorismatase activity
HTY60_RS15940	COG1535	isochorismatase
HTY60_RS15945	COG1021	2,3-dihydroxybenzoate-AMP ligase
HTY60_RS15950	COG1169	isochorismate synthase
HTY60_RS15955	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS15960	COG2819	hydrolase of the alpha beta superfamily
HTY60_RS15965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HTY60_RS15970	COG1268	BioY protein
HTY60_RS15975	COG2056	Na+-H+ antiporter family
HTY60_RS15985	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HTY60_RS16005	COG1252	NADH dehydrogenase
HTY60_RS16035	COG1131	(ABC) transporter
HTY60_RS16060	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HTY60_RS16065	COG0316	Belongs to the HesB IscA family
HTY60_RS16075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HTY60_RS16085	COG1252	NADH dehydrogenase
HTY60_RS16090	COG4837	Protein of unknown function (DUF1462)
HTY60_RS16095	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HTY60_RS16110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HTY60_RS16115	COG0460	homoserine dehydrogenase
HTY60_RS16120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HTY60_RS16125	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HTY60_RS16130	COG0647	UMP catabolic process
HTY60_RS16135	COG2445	Protein of unknown function DUF86
HTY60_RS16140	COG4470	Protein conserved in bacteria
HTY60_RS16150	COG0739	heme binding
HTY60_RS16160	COG0737	Belongs to the 5'-nucleotidase family
HTY60_RS16165	COG0730	response to heat
HTY60_RS16170	COG1801	Protein of unknown function DUF72
HTY60_RS16185	COG2508	Transcriptional regulator
HTY60_RS16195	COG3648	Uricase
HTY60_RS16195	COG3195	allantoin biosynthetic process
HTY60_RS16205	COG2814	Major facilitator Superfamily
HTY60_RS16210	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HTY60_RS16215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HTY60_RS16220	COG2356	endonuclease I
HTY60_RS16225	COG3842	ATPase activity
HTY60_RS16230	COG2188	Transcriptional regulator
HTY60_RS16235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HTY60_RS16240	COG0395	ABC-type sugar transport system, permease component
HTY60_RS16245	COG1175	transmembrane transport
HTY60_RS16250	COG1653	transport
HTY60_RS16255	COG2222	sugar isomerase
HTY60_RS16260	COG0789	Transcriptional regulator
HTY60_RS16285	COG0322	excinuclease ABC activity
HTY60_RS16290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HTY60_RS16305	COG3409	Peptidoglycan-binding domain 1 protein
HTY60_RS16325	COG3409	Peptidoglycan-binding domain 1 protein
HTY60_RS16325	COG5632	N-Acetylmuramoyl-L-alanine amidase
HTY60_RS16330	COG4824	toxin secretion phage lysis holin
HTY60_RS16350	COG5434	Belongs to the glycosyl hydrolase 28 family
HTY60_RS16355	COG1705	Flagellar rod assembly protein muramidase FlgJ
HTY60_RS16365	COG3953	SLT domain
HTY60_RS16365	COG5412	phage tail tape measure protein
HTY60_RS16465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HTY60_RS16465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HTY60_RS16515	COG1396	sequence-specific DNA binding
HTY60_RS16530	COG0719	Fe-S assembly protein
HTY60_RS16535	COG0822	iron-sulfur transferase activity
HTY60_RS16540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HTY60_RS16545	COG0719	Fe-S assembly protein
HTY60_RS16550	COG0396	ATPase activity
HTY60_RS16560	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HTY60_RS16565	COG1464	Belongs to the NlpA lipoprotein family
HTY60_RS16570	COG2011	ABC-type metal ion transport system permease component
HTY60_RS16575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HTY60_RS16585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTY60_RS16605	COG1393	Belongs to the ArsC family
HTY60_RS16610	COG1960	acyl-CoA dehydrogenase activity
HTY60_RS16615	COG0183	Belongs to the thiolase family
HTY60_RS16620	COG1250	3-hydroxyacyl-CoA dehydrogenase
HTY60_RS16620	COG1024	Enoyl-CoA hydratase
HTY60_RS16640	COG5577	PFAM Coat F domain
HTY60_RS16645	COG1846	Transcriptional regulator
HTY60_RS16650	COG0477	Major facilitator Superfamily
HTY60_RS16675	COG1120	ATPase activity
HTY60_RS16690	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS16695	COG0783	Belongs to the Dps family
HTY60_RS16700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HTY60_RS16705	COG0745	RESPONSE REGULATOR receiver
HTY60_RS16710	COG2770	Histidine kinase
HTY60_RS16710	COG2205	protein histidine kinase activity
HTY60_RS16720	COG1309	transcriptional regulator
HTY60_RS16725	COG0114	fumarate hydratase activity
HTY60_RS16735	COG0697	spore germination
HTY60_RS16740	COG0814	amino acid
HTY60_RS16750	COG2197	response regulator
HTY60_RS16755	COG4585	Histidine kinase
HTY60_RS16760	COG4758	membrane
HTY60_RS16765	COG3595	metallopeptidase activity
HTY60_RS16770	COG1842	Phage shock protein A
HTY60_RS16775	COG4758	membrane
HTY60_RS16780	COG2814	Major facilitator Superfamily
HTY60_RS16785	COG2096	Adenosyltransferase
HTY60_RS16790	COG1120	ATPase activity
HTY60_RS16795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTY60_RS16800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HTY60_RS16805	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS16810	COG3386	PFAM SMP-30 Gluconolaconase
HTY60_RS16815	COG2205	protein histidine kinase activity
HTY60_RS16820	COG0745	RESPONSE REGULATOR receiver
HTY60_RS16830	COG1191	sigma factor activity
HTY60_RS16840	COG2140	Oxalate decarboxylase
HTY60_RS16850	COG1120	ATPase activity
HTY60_RS16855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTY60_RS16860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTY60_RS16865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HTY60_RS16870	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HTY60_RS16875	COG0531	amino acid
HTY60_RS16885	COG1988	membrane-bound metal-dependent
HTY60_RS16895	COG1910	domain protein
HTY60_RS16900	COG0725	ABC transporter, periplasmic molybdate-binding protein
HTY60_RS16905	COG4149	molybdate abc transporter
HTY60_RS16910	COG2197	response regulator
HTY60_RS16920	COG1131	(ABC) transporter
HTY60_RS16930	COG0842	Transport permease protein
HTY60_RS16935	COG0656	L-ascorbic acid biosynthetic process
HTY60_RS16955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HTY60_RS16965	COG2860	membrane
HTY60_RS16975	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HTY60_RS16980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HTY60_RS16985	COG2217	Heavy metal translocating P-type atpase
HTY60_RS16990	COG2217	Heavy metal translocating P-type atpase
HTY60_RS16995	COG2608	mercury ion transmembrane transporter activity
HTY60_RS17000	COG1937	Protein conserved in bacteria
HTY60_RS17005	COG0673	inositol 2-dehydrogenase activity
HTY60_RS17015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HTY60_RS17020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HTY60_RS17025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HTY60_RS17030	COG1126	abc transporter atp-binding protein
HTY60_RS17035	COG0765	amino acid transport
HTY60_RS17040	COG0765	amino acid transport
HTY60_RS17045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HTY60_RS17050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HTY60_RS17055	COG0454	-acetyltransferase
HTY60_RS17060	COG0583	DNA-binding transcription factor activity
HTY60_RS17065	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS17070	COG2732	(Barnase) inhibitor
HTY60_RS17085	COG0557	exoribonuclease II activity
HTY60_RS17090	COG1647	Serine aminopeptidase, S33
HTY60_RS17095	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HTY60_RS17100	COG1476	TRANSCRIPTIONal
HTY60_RS17105	COG1396	sequence-specific DNA binding
HTY60_RS17110	COG1396	sequence-specific DNA binding
HTY60_RS17115	COG1733	regulation of RNA biosynthetic process
HTY60_RS17140	COG1131	(ABC) transporter
HTY60_RS17145	COG1174	glycine betaine transport
HTY60_RS17150	COG1732	Glycine betaine
HTY60_RS17155	COG1174	glycine betaine transport
HTY60_RS17160	COG1125	glycine betaine transport
HTY60_RS17160	COG0517	IMP dehydrogenase activity
HTY60_RS17165	COG1510	regulation of RNA biosynthetic process
HTY60_RS17170	COG1174	glycine betaine transport
HTY60_RS17175	COG1732	Glycine betaine
HTY60_RS17180	COG1174	glycine betaine transport
HTY60_RS17185	COG1125	glycine betaine transport
HTY60_RS17185	COG0517	IMP dehydrogenase activity
HTY60_RS17190	COG1510	regulation of RNA biosynthetic process
HTY60_RS17195	COG2095	MarC family integral membrane protein
HTY60_RS17200	COG3064	Membrane
HTY60_RS17205	COG4640	response to antibiotic
HTY60_RS17210	COG0456	acetyltransferase
HTY60_RS17225	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HTY60_RS17245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HTY60_RS17250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HTY60_RS17260	COG2234	aminopeptidase activity
HTY60_RS17280	COG0126	phosphoglycerate kinase activity
HTY60_RS17285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HTY60_RS17290	COG2390	Transcriptional regulator
HTY60_RS17300	COG1609	Transcriptional regulator
HTY60_RS17305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HTY60_RS17315	COG0697	spore germination
HTY60_RS17320	COG1113	amino acid transport
HTY60_RS17330	COG1737	Transcriptional regulator
HTY60_RS17335	COG1070	Carbohydrate kinase
HTY60_RS17360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HTY60_RS17365	COG2186	Transcriptional regulator
HTY60_RS17370	COG1620	l-lactate permease
HTY60_RS17375	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HTY60_RS17395	COG0110	maltose O-acetyltransferase activity
HTY60_RS17400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HTY60_RS17405	COG2244	polysaccharide biosynthetic process
HTY60_RS17410	COG1216	Glycosyl transferase, family 2
HTY60_RS17415	COG5039	Polysaccharide pyruvyl transferase
HTY60_RS17420	COG1216	Glycosyl transferase, family 2
HTY60_RS17430	COG0438	transferase activity, transferring glycosyl groups
HTY60_RS17435	COG1215	transferase activity, transferring glycosyl groups
HTY60_RS17440	COG0438	transferase activity, transferring glycosyl groups
HTY60_RS17445	COG1086	Polysaccharide biosynthesis protein
HTY60_RS17450	COG0489	protein tyrosine kinase activity
HTY60_RS17455	COG3944	biosynthesis protein
HTY60_RS17460	COG1396	sequence-specific DNA binding
HTY60_RS17465	COG2272	Belongs to the type-B carboxylesterase lipase family
HTY60_RS17475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HTY60_RS17490	COG2364	Membrane
HTY60_RS17495	COG0456	acetyltransferase
HTY60_RS17500	COG3479	Phenolic acid decarboxylase
HTY60_RS17545	COG2223	nitrite transmembrane transporter activity
HTY60_RS17550	COG1609	Transcriptional regulator
HTY60_RS17560	COG0583	DNA-binding transcription factor activity
HTY60_RS17565	COG2828	Protein conserved in bacteria
HTY60_RS17570	COG2814	Major facilitator Superfamily
HTY60_RS17570	COG0477	Major facilitator Superfamily
HTY60_RS17580	COG1611	Belongs to the LOG family
HTY60_RS17585	COG1694	Mazg nucleotide pyrophosphohydrolase
HTY60_RS17590	COG0659	secondary active sulfate transmembrane transporter activity
HTY60_RS17595	COG0288	reversible hydration of carbon dioxide
HTY60_RS17600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HTY60_RS17605	COG4290	ribonuclease
HTY60_RS17610	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HTY60_RS17615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HTY60_RS17625	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HTY60_RS17635	COG1051	belongs to the nudix hydrolase family
HTY60_RS17640	COG0492	ferredoxin-NADP+ reductase activity
HTY60_RS17645	COG0791	NLP P60 protein
HTY60_RS17645	COG3883	PFAM NLP P60 protein
HTY60_RS17650	COG0457	Tetratricopeptide repeat
HTY60_RS17655	COG5002	protein histidine kinase activity
HTY60_RS17660	COG0745	RESPONSE REGULATOR receiver
HTY60_RS17665	COG1132	(ABC) transporter
HTY60_RS17670	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HTY60_RS17670	COG0140	phosphoribosyl-ATP diphosphatase activity
HTY60_RS17695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HTY60_RS17710	COG4990	cell redox homeostasis
HTY60_RS17715	COG0110	maltose O-acetyltransferase activity
HTY60_RS17735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HTY60_RS17745	COG2188	Transcriptional regulator
HTY60_RS17750	COG1309	transcriptional regulator
HTY60_RS17755	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HTY60_RS17760	COG1950	PFAM Membrane protein of
HTY60_RS17765	COG1983	PspC domain protein
HTY60_RS17770	COG3595	metallopeptidase activity
HTY60_RS17785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HTY60_RS17795	COG4897	Protein conserved in bacteria
HTY60_RS17800	COG0574	Belongs to the PEP-utilizing enzyme family
HTY60_RS17800	COG3848	Pyruvate phosphate dikinase
HTY60_RS17805	COG1309	transcriptional regulator
HTY60_RS17810	COG2814	Major facilitator Superfamily
HTY60_RS17825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HTY60_RS17835	COG0793	Belongs to the peptidase S41A family
HTY60_RS17835	COG3409	Peptidoglycan-binding domain 1 protein
HTY60_RS17840	COG3420	alginic acid biosynthetic process
HTY60_RS17845	COG2177	Part of the ABC transporter FtsEX involved in
HTY60_RS17850	COG2884	Cell division ATP-binding protein ftsE
HTY60_RS17855	COG2010	Cytochrome c
HTY60_RS17860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HTY60_RS17875	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HTY60_RS17890	COG1516	flagellar protein fliS
HTY60_RS17895	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HTY60_RS17900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HTY60_RS17920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HTY60_RS17930	COG3418	PFAM FlgN family protein
HTY60_RS17935	COG2747	anti-sigma28 factor FlgM
HTY60_RS17945	COG1040	competence protein
HTY60_RS17955	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HTY60_RS17960	COG1307	EDD domain protein, DegV family
HTY60_RS17965	COG2197	response regulator
HTY60_RS17970	COG4585	Histidine kinase
HTY60_RS17975	COG1739	Uncharacterized protein family UPF0029
HTY60_RS17980	COG1316	TRANSCRIPTIONal
HTY60_RS17985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HTY60_RS17990	COG0438	transferase activity, transferring glycosyl groups
HTY60_RS17995	COG1215	transferase activity, transferring glycosyl groups
HTY60_RS18000	COG3206	protein involved in exopolysaccharide biosynthesis
HTY60_RS18005	COG3307	-O-antigen
HTY60_RS18010	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HTY60_RS18015	COG0297	glycogen (starch) synthase activity
HTY60_RS18015	COG0438	transferase activity, transferring glycosyl groups
HTY60_RS18020	COG2244	polysaccharide biosynthetic process
HTY60_RS18030	COG0860	N-Acetylmuramoyl-L-alanine amidase
HTY60_RS18030	COG2247	cell wall binding repeat
HTY60_RS18035	COG2385	sporulation resulting in formation of a cellular spore
HTY60_RS18035	COG2247	cell wall binding repeat
HTY60_RS18045	COG1316	TRANSCRIPTIONal
HTY60_RS18050	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HTY60_RS18055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HTY60_RS18060	COG1134	teichoic acid transport
HTY60_RS18065	COG1682	transport, permease protein
HTY60_RS18070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HTY60_RS18075	COG0438	transferase activity, transferring glycosyl groups
HTY60_RS18080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HTY60_RS18085	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HTY60_RS18090	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HTY60_RS18095	COG4193	domain, Protein
HTY60_RS18100	COG1482	cell wall glycoprotein biosynthetic process
HTY60_RS18105	COG0697	spore germination
HTY60_RS18110	COG0814	amino acid
HTY60_RS18125	COG1215	transferase activity, transferring glycosyl groups
HTY60_RS18130	COG2814	Major facilitator Superfamily
HTY60_RS18135	COG1316	TRANSCRIPTIONal
HTY60_RS18140	COG0561	phosphatase activity
HTY60_RS18145	COG2433	Pfam Transposase IS66
HTY60_RS18150	COG0791	NLP P60 protein
HTY60_RS18160	COG2843	Capsule synthesis protein
HTY60_RS18170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HTY60_RS18175	COG0697	spore germination
HTY60_RS18180	COG0814	amino acid
HTY60_RS18190	COG1609	Transcriptional regulator
HTY60_RS18195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HTY60_RS18205	COG1129	ABC transporter
HTY60_RS18210	COG1172	Belongs to the binding-protein-dependent transport system permease family
HTY60_RS18215	COG1879	ABC-type sugar transport system periplasmic component
HTY60_RS18220	COG3103	Sh3 type 3 domain protein
HTY60_RS18225	COG2249	NAD(P)H dehydrogenase (quinone) activity
HTY60_RS18230	COG3527	Alpha-acetolactate decarboxylase
HTY60_RS18235	COG0028	Belongs to the TPP enzyme family
HTY60_RS18240	COG0583	DNA-binding transcription factor activity
HTY60_RS18245	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HTY60_RS18260	COG5337	Spore coat protein CotH
HTY60_RS18270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HTY60_RS18280	COG0405	Gamma-glutamyltransferase
HTY60_RS18285	COG1522	sequence-specific DNA binding
HTY60_RS18290	COG2059	Chromate
HTY60_RS18295	COG2059	Chromate
HTY60_RS18330	COG5444	nuclease activity
HTY60_RS18345	COG3878	Protein conserved in bacteria
HTY60_RS18350	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HTY60_RS18355	COG4464	protein tyrosine phosphatase activity
HTY60_RS18360	COG0489	protein tyrosine kinase activity
HTY60_RS18365	COG3944	biosynthesis protein
HTY60_RS18375	COG4715	Zinc finger, swim domain protein
HTY60_RS18380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HTY60_RS18385	COG0561	phosphatase activity
HTY60_RS18390	COG1349	DNA-binding transcription factor activity
HTY60_RS18395	COG0629	single-stranded DNA binding
HTY60_RS18420	COG0457	Tetratricopeptide repeat
HTY60_RS18425	COG4786	Flagellar basal body rod
HTY60_RS18430	COG4786	Flagellar basal body rod
HTY60_RS18435	COG1077	Cell shape determining protein MreB Mrl
HTY60_RS18440	COG1609	Transcriptional regulator
HTY60_RS18445	COG1846	Transcriptional regulator
HTY60_RS18455	COG1953	Uracil, thiamine, allantoin
HTY60_RS18460	COG0477	Major facilitator Superfamily
HTY60_RS18465	COG1335	isochorismatase
HTY60_RS18470	COG0004	ammonium transporteR
HTY60_RS18475	COG0347	Belongs to the P(II) protein family
HTY60_RS18480	COG0772	Belongs to the SEDS family
HTY60_RS18485	COG0671	phosphoesterase, PA-phosphatase related
HTY60_RS18495	COG0739	heme binding
HTY60_RS18500	COG1247	-acetyltransferase
HTY60_RS18515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HTY60_RS18530	COG2910	NAD(P)H-binding
HTY60_RS18535	COG1959	2 iron, 2 sulfur cluster binding
HTY60_RS18550	COG0831	urea catabolic process
HTY60_RS18555	COG3237	CsbD-like
HTY60_RS18560	COG1994	Peptidase M50
HTY60_RS18575	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HTY60_RS18585	COG2304	oxidoreductase activity
HTY60_RS18590	COG2304	oxidoreductase activity
HTY60_RS18595	COG2385	sporulation resulting in formation of a cellular spore
HTY60_RS18600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HTY60_RS18610	COG4836	Membrane
HTY60_RS18680	COG0698	ribose 5-phosphate isomerase
HTY60_RS18685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HTY60_RS18695	COG0009	L-threonylcarbamoyladenylate synthase
HTY60_RS18700	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HTY60_RS18720	COG2890	protein-(glutamine-N5) methyltransferase activity
HTY60_RS18725	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HTY60_RS18730	COG0346	lactoylglutathione lyase activity
HTY60_RS18735	COG0789	Transcriptional regulator
HTY60_RS18740	COG0679	Auxin Efflux Carrier
HTY60_RS18745	COG0281	malic enzyme
HTY60_RS18760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HTY60_RS18765	COG1494	fructose-1,6-bisphosphatase
HTY60_RS18770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HTY60_RS18780	COG0191	fructose-bisphosphate aldolase activity
HTY60_RS18785	COG2204	response regulator
HTY60_RS18790	COG4821	SIS domain
HTY60_RS18805	COG0247	lactate metabolic process
HTY60_RS18805	COG2181	nitrate reductase activity
HTY60_RS18810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HTY60_RS18825	COG1132	(ABC) transporter
HTY60_RS18830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HTY60_RS18835	COG2181	nitrate reductase activity
HTY60_RS18840	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HTY60_RS18845	COG1140	nitrate reductase beta subunit
HTY60_RS18850	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HTY60_RS18855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HTY60_RS18865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HTY60_RS18870	COG2223	nitrite transmembrane transporter activity
HTY60_RS18880	COG4506	Protein conserved in bacteria
HTY60_RS18895	COG0457	Tetratricopeptide repeat
HTY60_RS18905	COG0010	Belongs to the arginase family
HTY60_RS18910	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HTY60_RS18915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HTY60_RS18930	COG1994	Peptidase M50
HTY60_RS18935	COG1942	4-Oxalocrotonate Tautomerase
HTY60_RS18940	COG1846	Transcriptional regulator
HTY60_RS18945	COG0531	amino acid
HTY60_RS18950	COG3465	dGTPase activity
HTY60_RS18955	COG1078	dGTPase activity
HTY60_RS18970	COG1695	Transcriptional regulator
HTY60_RS18980	COG1131	(ABC) transporter
HTY60_RS18985	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HTY60_RS19015	COG0583	DNA-binding transcription factor activity
HTY60_RS19020	COG2855	membrane
HTY60_RS19025	COG0280	phosphate acetyltransferase
HTY60_RS19045	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS19050	COG0436	Aminotransferase
HTY60_RS19060	COG0151	Belongs to the GarS family
HTY60_RS19070	COG1917	Cupin 2, conserved barrel domain protein
HTY60_RS19080	COG2814	Major facilitator Superfamily
HTY60_RS19085	COG2814	Major facilitator Superfamily
HTY60_RS19090	COG0833	amino acid
HTY60_RS19095	COG4187	Peptidase family M20/M25/M40
HTY60_RS19100	COG1012	belongs to the aldehyde dehydrogenase family
HTY60_RS19105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HTY60_RS19115	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HTY60_RS19120	COG1091	dTDP-4-dehydrorhamnose reductase activity
HTY60_RS19125	COG1088	dTDP-glucose 4,6-dehydratase activity
HTY60_RS19130	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HTY60_RS19135	COG3980	spore coat polysaccharide biosynthesis protein
HTY60_RS19140	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HTY60_RS19145	COG2089	acid synthase
HTY60_RS19150	COG0456	acetyltransferase
HTY60_RS19155	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HTY60_RS19160	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HTY60_RS19165	COG0463	Glycosyl transferase, family 2
HTY60_RS19175	COG2363	Small membrane protein
HTY60_RS19180	COG2233	PERMEase
HTY60_RS19195	COG1216	Glycosyl transferase, family 2
HTY60_RS19205	COG0351	phosphomethylpyrimidine kinase
HTY60_RS19215	COG1621	beta-fructofuranosidase activity
HTY60_RS19220	COG1263	PTS System
HTY60_RS19220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HTY60_RS19225	COG3711	transcriptional antiterminator
HTY60_RS19235	COG1404	Belongs to the peptidase S8 family
HTY60_RS19240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HTY60_RS19245	COG2378	regulation of single-species biofilm formation
HTY60_RS19265	COG0778	Nitroreductase
HTY60_RS19270	COG0772	Belongs to the SEDS family
HTY60_RS19275	COG0454	-acetyltransferase
HTY60_RS19295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HTY60_RS19300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HTY60_RS19305	COG2261	transglycosylase associated protein
HTY60_RS19310	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HTY60_RS19315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HTY60_RS19320	COG2246	polysaccharide biosynthetic process
HTY60_RS19325	COG1309	transcriptional regulator
HTY60_RS19345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HTY60_RS19350	COG2837	iron assimilation
HTY60_RS19355	COG2822	iron ion transport
HTY60_RS19360	COG0672	)-iron permease
HTY60_RS19375	COG0583	DNA-binding transcription factor activity
HTY60_RS19385	COG1346	cytolysis
HTY60_RS19390	COG4895	conserved protein (DUF2196)
HTY60_RS19395	COG0789	Transcriptional regulator
HTY60_RS19400	COG5504	Zn-dependent protease
HTY60_RS19405	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HTY60_RS19410	COG0346	lactoylglutathione lyase activity
HTY60_RS19415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HTY60_RS19420	COG1404	Belongs to the peptidase S8 family
HTY60_RS19425	COG1442	glycosyl transferase family 8
HTY60_RS19430	COG2357	RelA SpoT domain protein
HTY60_RS19435	COG1575	Belongs to the MenA family. Type 1 subfamily
HTY60_RS19450	COG1696	Membrane protein involved in D-alanine export
HTY60_RS19460	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HTY60_RS19465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HTY60_RS19470	COG1486	melibiose metabolic process
HTY60_RS19475	COG1447	Phosphotransferase system cellobiose-specific component IIA
HTY60_RS19480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HTY60_RS19485	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HTY60_RS19490	COG3711	transcriptional antiterminator
HTY60_RS19490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HTY60_RS19500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTY60_RS19505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTY60_RS19515	COG0640	Transcriptional regulator
HTY60_RS19520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HTY60_RS19525	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HTY60_RS19530	COG1447	Phosphotransferase system cellobiose-specific component IIA
HTY60_RS19535	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HTY60_RS19540	COG2723	6-phospho-beta-galactosidase activity
HTY60_RS19545	COG1940	carbohydrate kinase activity
HTY60_RS19550	COG1482	cell wall glycoprotein biosynthetic process
HTY60_RS19560	COG0753	catalase activity
HTY60_RS19565	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HTY60_RS19570	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HTY60_RS19580	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HTY60_RS19585	COG4988	ABC transporter
HTY60_RS19590	COG1294	oxidase, subunit
HTY60_RS19595	COG1271	oxidase subunit
HTY60_RS19600	COG3493	citrate carrier protein
HTY60_RS19605	COG0726	polysaccharide deacetylase
HTY60_RS19610	COG3842	ATPase activity
HTY60_RS19615	COG2508	Transcriptional regulator
HTY60_RS19620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HTY60_RS19630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HTY60_RS19645	COG4894	glucomannan catabolic process
HTY60_RS19650	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HTY60_RS19655	COG0500	methyltransferase
HTY60_RS19660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HTY60_RS19680	COG0753	catalase activity
HTY60_RS19680	COG0693	protein deglycase activity
HTY60_RS19690	COG2273	Hydrolase Family 16
HTY60_RS19695	COG3711	transcriptional antiterminator
HTY60_RS19700	COG2270	Major facilitator Superfamily
HTY60_RS19705	COG0513	Belongs to the DEAD box helicase family
HTY60_RS19755	COG0697	spore germination
HTY60_RS19760	COG0589	response to stress
HTY60_RS19765	COG2723	6-phospho-beta-galactosidase activity
HTY60_RS19770	COG1263	PTS System
HTY60_RS19770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HTY60_RS19770	COG2190	(PTS) system
HTY60_RS19785	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HTY60_RS19805	COG3507	Belongs to the glycosyl hydrolase 43 family
HTY60_RS19830	COG0010	Belongs to the arginase family
HTY60_RS19835	COG0833	amino acid
HTY60_RS19840	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HTY60_RS19845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HTY60_RS19855	COG2390	Transcriptional regulator
HTY60_RS19860	COG0561	phosphatase activity
HTY60_RS19890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HTY60_RS19895	COG5294	Protein conserved in bacteria
HTY60_RS19900	COG0577	efflux transmembrane transporter activity
HTY60_RS19905	COG1136	(ABC) transporter
HTY60_RS19910	COG2205	protein histidine kinase activity
HTY60_RS19915	COG0745	RESPONSE REGULATOR receiver
HTY60_RS19930	COG1082	Xylose isomerase domain protein TIM barrel
HTY60_RS19940	COG2814	Major facilitator Superfamily
HTY60_RS19970	COG1349	DNA-binding transcription factor activity
HTY60_RS19975	COG0667	Aldo Keto reductase
HTY60_RS19980	COG2814	Major facilitator Superfamily
HTY60_RS19990	COG1028	Short-chain dehydrogenase reductase Sdr
HTY60_RS19995	COG2197	response regulator
HTY60_RS20000	COG4585	Histidine kinase
HTY60_RS20005	COG3239	Fatty acid desaturase
HTY60_RS20010	COG1309	transcriptional regulator
HTY60_RS20015	COG1012	belongs to the aldehyde dehydrogenase family
HTY60_RS20020	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HTY60_RS20030	COG0640	Transcriptional regulator
HTY60_RS20035	COG2814	Major facilitator Superfamily
HTY60_RS20040	COG1714	RDD family
HTY60_RS20050	COG0450	alkyl hydroperoxide reductase
HTY60_RS20055	COG3634	alkyl hydroperoxide reductase activity
HTY60_RS20065	COG1113	amino acid transport
HTY60_RS20120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HTY60_RS20135	COG2323	membrane
HTY60_RS20160	COG2080	2 iron, 2 sulfur cluster binding
HTY60_RS20175	COG2068	MobA-Related Protein
HTY60_RS20180	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HTY60_RS20230	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HTY60_RS20235	COG0667	Aldo Keto reductase
HTY60_RS20240	COG0456	acetyltransferase
HTY60_RS20245	COG0457	Tetratricopeptide repeat
HTY60_RS20250	COG0010	Belongs to the arginase family
HTY60_RS20255	COG0833	amino acid
HTY60_RS20260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HTY60_RS20265	COG5658	integral membrane protein
HTY60_RS20270	COG0640	Transcriptional regulator
HTY60_RS20275	COG3829	transcription factor binding
HTY60_RS20290	COG3850	Histidine kinase
HTY60_RS20290	COG5002	protein histidine kinase activity
HTY60_RS20305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HTY60_RS20310	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HTY60_RS20320	COG4863	YycH protein
HTY60_RS20325	COG5002	protein histidine kinase activity
HTY60_RS20330	COG0745	RESPONSE REGULATOR receiver
HTY60_RS20360	COG0346	lactoylglutathione lyase activity
HTY60_RS20365	COG0305	Participates in initiation and elongation during chromosome replication
HTY60_RS20380	COG3093	addiction module antidote protein HigA
HTY60_RS20395	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HTY60_RS20400	COG0438	transferase activity, transferring glycosyl groups
HTY60_RS20420	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HTY60_RS20425	COG4241	membrane
HTY60_RS20435	COG5577	PFAM Coat F domain
HTY60_RS20440	COG1733	regulation of RNA biosynthetic process
HTY60_RS20450	COG0697	spore germination
HTY60_RS20455	COG1621	beta-fructofuranosidase activity
HTY60_RS20460	COG1621	beta-fructofuranosidase activity
HTY60_RS20470	COG2318	DinB family
HTY60_RS20475	COG2211	Major facilitator Superfamily
HTY60_RS20485	COG0778	Nitroreductase
HTY60_RS20490	COG1846	Transcriptional regulator
HTY60_RS20495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HTY60_RS20500	COG1846	Transcriptional regulator
HTY60_RS20505	COG2153	protein acetylation
HTY60_RS20510	COG0640	Transcriptional regulator
HTY60_RS20515	COG2267	carboxylic ester hydrolase activity
HTY60_RS20535	COG1266	CAAX protease self-immunity
HTY60_RS20540	COG2814	Major facilitator Superfamily
HTY60_RS20540	COG0477	Major facilitator Superfamily
HTY60_RS20545	COG0346	lactoylglutathione lyase activity
HTY60_RS20555	COG0708	Exodeoxyribonuclease III
HTY60_RS20560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HTY60_RS20565	COG2169	Transcriptional regulator
HTY60_RS20575	COG0629	single-stranded DNA binding
HTY60_RS20585	COG0012	GTP binding
HTY60_RS20590	COG0243	molybdopterin cofactor binding
HTY60_RS20595	COG4481	Protein conserved in bacteria
HTY60_RS20600	COG3949	Membrane
HTY60_RS20615	COG1475	DNA binding
HTY60_RS20620	COG1192	Involved in chromosome partitioning
HTY60_RS20645	COG1847	R3H domain protein
HTY60_RS20650	COG0706	membrane insertase activity