locus-tag	class	description
MK616_RS00010	COG0592	DNA-directed DNA polymerase activity
MK616_RS00015	COG2501	S4 domain
MK616_RS00030	COG0187	DNA topoisomerase II activity
MK616_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MK616_RS00070	COG0516	GMP reductase activity
MK616_RS00070	COG0517	IMP dehydrogenase activity
MK616_RS00075	COG1686	Belongs to the peptidase S11 family
MK616_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
MK616_RS00105	COG1428	Deoxynucleoside kinase
MK616_RS00110	COG1428	Deoxynucleoside kinase
MK616_RS00115	COG1388	LysM domain
MK616_RS00115	COG3858	chitin binding
MK616_RS00120	COG1335	isochorismatase
MK616_RS00125	COG0590	tRNA wobble adenosine to inosine editing
MK616_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MK616_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MK616_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
MK616_RS00195	COG3853	Toxic anion resistance protein (TelA)
MK616_RS00200	COG1982	Orn Lys Arg decarboxylase major
MK616_RS00210	COG3870	Protein conserved in bacteria
MK616_RS00215	COG1728	Protein conserved in bacteria
MK616_RS00220	COG0470	DNA polymerase III
MK616_RS00225	COG1774	PSP1 C-terminal conserved region
MK616_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MK616_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MK616_RS00250	COG2002	toxin-antitoxin pair type II binding
MK616_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MK616_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MK616_RS00260	COG0084	hydrolase, TatD family'
MK616_RS00265	COG3583	domain protein
MK616_RS00265	COG3584	3D domain protein
MK616_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MK616_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MK616_RS00285	COG4466	Protein conserved in bacteria
MK616_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MK616_RS00305	COG0251	oxidation-reduction process
MK616_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MK616_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MK616_RS00345	COG2002	toxin-antitoxin pair type II binding
MK616_RS00350	COG2244	polysaccharide biosynthetic process
MK616_RS00355	COG3956	TIGRFAM MazG family protein
MK616_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MK616_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MK616_RS00380	COG1098	S1 RNA binding domain
MK616_RS00395	COG2208	phosphoserine phosphatase activity
MK616_RS00400	COG2304	oxidoreductase activity
MK616_RS00405	COG0515	serine threonine protein kinase
MK616_RS00410	COG0037	tRNA processing
MK616_RS00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MK616_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MK616_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MK616_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MK616_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MK616_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
MK616_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MK616_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MK616_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MK616_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MK616_RS00475	COG1396	sequence-specific DNA binding
MK616_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MK616_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MK616_RS00565	COG4463	regulation of RNA biosynthetic process
MK616_RS00570	COG3880	PFAM UvrB UvrC protein
MK616_RS00580	COG0542	response to heat
MK616_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MK616_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MK616_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
MK616_RS00615	COG1045	serine acetyltransferase
MK616_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MK616_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MK616_RS00635	COG3688	RNA-binding protein containing a PIN domain
MK616_RS00640	COG1595	DNA-templated transcription, initiation
MK616_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MK616_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
MK616_RS00680	COG2813	Specifically methylates the guanine in position
MK616_RS00695	COG1358	cellular component organization or biogenesis
MK616_RS00720	COG0596	Alpha beta hydrolase
MK616_RS00830	COG0201	protein transport
MK616_RS00840	COG0024	Methionine aminopeptidase
MK616_RS00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MK616_RS00880	COG1122	ATPase activity
MK616_RS00885	COG1122	ATPase activity
MK616_RS00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MK616_RS00910	COG2226	methyltransferase
MK616_RS00915	COG2318	DinB family
MK616_RS00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
MK616_RS00930	COG0489	protein tyrosine kinase activity
MK616_RS00940	COG2194	sulfuric ester hydrolase activity
MK616_RS00945	COG0726	polysaccharide deacetylase
MK616_RS01005	COG0738	Major facilitator superfamily
MK616_RS01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MK616_RS01025	COG0659	secondary active sulfate transmembrane transporter activity
MK616_RS01030	COG0385	Bile acid
MK616_RS01035	COG2819	hydrolase of the alpha beta superfamily
MK616_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MK616_RS01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MK616_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MK616_RS01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MK616_RS01055	COG2207	Transcriptional regulator
MK616_RS01060	COG3876	Protein conserved in bacteria
MK616_RS01065	COG1472	Belongs to the glycosyl hydrolase 3 family
MK616_RS01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MK616_RS01075	COG1263	PTS System
MK616_RS01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MK616_RS01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MK616_RS01090	COG1683	Conserved Protein
MK616_RS01120	COG1595	DNA-templated transcription, initiation
MK616_RS01125	COG5662	AntiSigma factor
MK616_RS01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MK616_RS01135	COG4856	YbbR-like protein
MK616_RS01175	COG1346	cytolysis
MK616_RS01180	COG1380	Effector of murein hydrolase LrgA
MK616_RS01185	COG1846	Transcriptional regulator
MK616_RS01190	COG1113	amino acid transport
MK616_RS01195	COG1011	Hydrolase
MK616_RS01200	COG4585	Histidine kinase
MK616_RS01205	COG2197	response regulator
MK616_RS01210	COG1131	(ABC) transporter
MK616_RS01250	COG0531	amino acid
MK616_RS01265	COG0584	glycerophosphoryl diester phosphodiesterase
MK616_RS01270	COG2271	Major facilitator Superfamily
MK616_RS01280	COG2368	4-hydroxyphenylacetate
MK616_RS01290	COG3409	Peptidoglycan-binding domain 1 protein
MK616_RS01305	COG0371	Dehydrogenase
MK616_RS01315	COG1183	phosphatidylcholine synthase activity
MK616_RS01320	COG0586	Pfam SNARE associated Golgi protein
MK616_RS01325	COG0688	phosphatidylethanolamine metabolic process
MK616_RS01340	COG1301	dicarboxylic acid transport
MK616_RS01345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MK616_RS01350	COG0833	amino acid
MK616_RS01355	COG2040	homocysteine
MK616_RS01360	COG1115	amino acid carrier protein
MK616_RS01365	COG2066	Belongs to the glutaminase family
MK616_RS01370	COG4191	Histidine kinase
MK616_RS01375	COG0784	Response regulator, receiver
MK616_RS01380	COG3173	Aminoglycoside phosphotransferase
MK616_RS01395	COG3773	Cell wall hydrolase
MK616_RS01400	COG3540	Alkaline phosphatase
MK616_RS01405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MK616_RS01410	COG0805	protein transport
MK616_RS01420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MK616_RS01425	COG0477	Major facilitator Superfamily
MK616_RS01430	COG1309	transcriptional regulator
MK616_RS01435	COG0252	asparaginase activity
MK616_RS01440	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MK616_RS01445	COG1405	negative regulation of cell septum assembly
MK616_RS01445	COG3012	SEC-C Motif Domain Protein
MK616_RS01450	COG0667	Aldo Keto reductase
MK616_RS01460	COG1595	DNA-templated transcription, initiation
MK616_RS01465	COG1595	DNA-templated transcription, initiation
MK616_RS01470	COG1876	peptidase activity
MK616_RS01475	COG0457	Tetratricopeptide repeat
MK616_RS01480	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS01490	COG0366	Alpha amylase catalytic
MK616_RS01495	COG0803	Belongs to the bacterial solute-binding protein 9 family
MK616_RS01500	COG1121	(ABC) transporter
MK616_RS01505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MK616_RS01510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MK616_RS01515	COG2310	stress, protein
MK616_RS01520	COG2310	stress, protein
MK616_RS01525	COG2310	stress, protein
MK616_RS01530	COG0861	Integral membrane protein TerC family
MK616_RS01540	COG3853	Toxic anion resistance protein (TelA)
MK616_RS01545	COG0477	Major facilitator Superfamily
MK616_RS01550	COG0517	IMP dehydrogenase activity
MK616_RS01550	COG4175	Glycine betaine
MK616_RS01555	COG4176	ABC-type proline glycine betaine transport system permease component
MK616_RS01560	COG2113	Glycine betaine
MK616_RS01565	COG1473	amidohydrolase
MK616_RS01570	COG1288	antiporter activity
MK616_RS01580	COG0366	Alpha amylase catalytic
MK616_RS01590	COG2814	Major facilitator Superfamily
MK616_RS01595	COG1846	Transcriptional regulator
MK616_RS01600	COG1280	lysine exporter protein (LysE YggA)
MK616_RS01605	COG3403	YqcI/YcgG family
MK616_RS01610	COG1113	amino acid transport
MK616_RS01615	COG3665	Urea carboxylase-associated protein
MK616_RS01630	COG1660	Displays ATPase and GTPase activities
MK616_RS01640	COG2271	Major facilitator Superfamily
MK616_RS01645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MK616_RS01650	COG3458	cephalosporin-C deacetylase activity
MK616_RS01655	COG3541	Predicted nucleotidyltransferase
MK616_RS01660	COG0506	proline dehydrogenase activity
MK616_RS01665	COG1012	belongs to the aldehyde dehydrogenase family
MK616_RS01670	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MK616_RS01675	COG2508	Transcriptional regulator
MK616_RS01685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MK616_RS01685	COG1587	Uroporphyrinogen-III synthase
MK616_RS01690	COG2146	nitrite reductase [NAD(P)H] activity
MK616_RS01695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MK616_RS01700	COG0243	molybdopterin cofactor binding
MK616_RS01705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MK616_RS01710	COG2223	nitrite transmembrane transporter activity
MK616_RS01715	COG0523	cobalamin synthesis protein
MK616_RS01720	COG1063	alcohol dehydrogenase
MK616_RS01725	COG1714	RDD family
MK616_RS01735	COG2723	6-phospho-beta-galactosidase activity
MK616_RS01745	COG3209	COG3209 Rhs family protein
MK616_RS01750	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MK616_RS01755	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MK616_RS01760	COG1733	regulation of RNA biosynthetic process
MK616_RS01765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS01785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS01790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS01795	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
MK616_RS01810	COG2364	Membrane
MK616_RS01815	COG1126	abc transporter atp-binding protein
MK616_RS01820	COG0765	amino acid transport
MK616_RS01825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MK616_RS01830	COG0583	DNA-binding transcription factor activity
MK616_RS01835	COG0163	prenyltransferase activity
MK616_RS01840	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MK616_RS01855	COG3104	oligopeptide transport
MK616_RS01860	COG5434	Belongs to the glycosyl hydrolase 28 family
MK616_RS01870	COG0697	spore germination
MK616_RS01880	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MK616_RS01885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MK616_RS01890	COG0456	acetyltransferase
MK616_RS01895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MK616_RS01900	COG0765	amino acid transport
MK616_RS01905	COG1126	abc transporter atp-binding protein
MK616_RS01910	COG1473	amidohydrolase
MK616_RS01915	COG2079	MmgE PrpD family protein
MK616_RS01920	COG1136	(ABC) transporter
MK616_RS01925	COG0577	efflux transmembrane transporter activity
MK616_RS01930	COG0745	RESPONSE REGULATOR receiver
MK616_RS01935	COG5002	protein histidine kinase activity
MK616_RS01935	COG3850	Histidine kinase
MK616_RS01940	COG0457	Tetratricopeptide repeat
MK616_RS01955	COG0527	aspartate kinase activity
MK616_RS01960	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MK616_RS01965	COG4605	iron ion homeostasis
MK616_RS01970	COG4604	ABC transporter, ATP-binding protein
MK616_RS01975	COG4607	ABC-type enterochelin transport system periplasmic component
MK616_RS01980	COG2814	Major facilitator Superfamily
MK616_RS01985	COG1309	transcriptional regulator
MK616_RS01990	COG0778	Nitroreductase
MK616_RS01995	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
MK616_RS02000	COG0640	Transcriptional regulator
MK616_RS02005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MK616_RS02010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MK616_RS02015	COG1012	belongs to the aldehyde dehydrogenase family
MK616_RS02020	COG4975	Glucose uptake
MK616_RS02025	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS02030	COG4549	nuclear export factor GLE1
MK616_RS02035	COG1276	copper resistance
MK616_RS02035	COG2372	response to copper ion
MK616_RS02040	COG1349	DNA-binding transcription factor activity
MK616_RS02050	COG2213	PTS system mannitol-specific
MK616_RS02055	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MK616_RS02065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MK616_RS02075	COG0561	phosphatase activity
MK616_RS02085	COG1914	H( )-stimulated, divalent metal cation uptake system
MK616_RS02095	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MK616_RS02100	COG1984	allophanate hydrolase subunit 2
MK616_RS02105	COG1414	Transcriptional regulator
MK616_RS02110	COG2755	lipolytic protein G-D-S-L family
MK616_RS02120	COG2329	Antibiotic biosynthesis monooxygenase
MK616_RS02125	COG0768	penicillin binding
MK616_RS02130	COG4989	oxidoreductase activity
MK616_RS02135	COG3711	transcriptional antiterminator
MK616_RS02140	COG0318	PFAM AMP-dependent synthetase and ligase
MK616_RS02145	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS02150	COG1917	Cupin 2, conserved barrel domain protein
MK616_RS02155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MK616_RS02160	COG3871	stress protein (general stress protein 26)
MK616_RS02170	COG2814	Major facilitator Superfamily
MK616_RS02175	COG1522	sequence-specific DNA binding
MK616_RS02180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MK616_RS02180	COG0551	DNA topoisomerase type I activity
MK616_RS02185	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MK616_RS02190	COG3706	GGDEF domain
MK616_RS02195	COG5298	Protein conserved in bacteria
MK616_RS02200	COG1215	transferase activity, transferring glycosyl groups
MK616_RS02210	COG0531	amino acid
MK616_RS02215	COG0494	nUDIX hydrolase
MK616_RS02220	COG0028	Belongs to the TPP enzyme family
MK616_RS02250	COG1914	H( )-stimulated, divalent metal cation uptake system
MK616_RS02270	COG2076	Multidrug Resistance protein
MK616_RS02275	COG2217	Heavy metal translocating P-type atpase
MK616_RS02280	COG3729	General stress protein
MK616_RS02285	COG0662	Cupin 2, conserved barrel domain protein
MK616_RS02290	COG2329	Antibiotic biosynthesis monooxygenase
MK616_RS02295	COG3546	catalase activity
MK616_RS02300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MK616_RS02305	COG3290	protein histidine kinase activity
MK616_RS02310	COG4565	transcriptional regulatory protein
MK616_RS02315	COG1301	dicarboxylic acid transport
MK616_RS02320	COG0628	permease
MK616_RS02325	COG1131	(ABC) transporter
MK616_RS02330	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MK616_RS02340	COG1960	acyl-CoA dehydrogenase activity
MK616_RS02355	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MK616_RS02360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MK616_RS02370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MK616_RS02375	COG0513	Belongs to the DEAD box helicase family
MK616_RS02380	COG3402	PFAM membrane-flanked domain
MK616_RS02385	COG3428	Bacterial PH domain
MK616_RS02390	COG0705	Rhomboid family
MK616_RS02400	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MK616_RS02405	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MK616_RS02410	COG0864	Transcriptional regulator
MK616_RS02415	COG2337	Toxic component of a toxin-antitoxin (TA) module
MK616_RS02420	COG1366	Belongs to the anti-sigma-factor antagonist family
MK616_RS02425	COG1366	Belongs to the anti-sigma-factor antagonist family
MK616_RS02430	COG2172	sigma factor antagonist activity
MK616_RS02435	COG2208	phosphoserine phosphatase activity
MK616_RS02440	COG1366	Belongs to the anti-sigma-factor antagonist family
MK616_RS02450	COG1191	sigma factor activity
MK616_RS02455	COG2208	phosphoserine phosphatase activity
MK616_RS02460	COG2183	response to ionizing radiation
MK616_RS02515	COG2249	NAD(P)H dehydrogenase (quinone) activity
MK616_RS02535	COG0477	Major facilitator Superfamily
MK616_RS02550	COG2030	dehydratase
MK616_RS02565	COG1959	2 iron, 2 sulfur cluster binding
MK616_RS02570	COG2910	NAD(P)H-binding
MK616_RS02580	COG1309	transcriptional regulator
MK616_RS02585	COG3239	Fatty acid desaturase
MK616_RS02590	COG1278	Cold shock
MK616_RS02595	COG1329	Transcriptional regulator
MK616_RS02600	COG1937	Protein conserved in bacteria
MK616_RS02605	COG2210	Belongs to the sulfur carrier protein TusA family
MK616_RS02610	COG1054	Belongs to the UPF0176 family
MK616_RS02615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MK616_RS02615	COG0425	Belongs to the sulfur carrier protein TusA family
MK616_RS02625	COG0425	Belongs to the sulfur carrier protein TusA family
MK616_RS02630	COG0730	response to heat
MK616_RS02635	COG1794	racemase activity, acting on amino acids and derivatives
MK616_RS02650	COG3621	Patatin-like phospholipase
MK616_RS02660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MK616_RS02665	COG1802	Transcriptional regulator
MK616_RS02670	COG0251	oxidation-reduction process
MK616_RS02675	COG0814	amino acid
MK616_RS02680	COG1473	amidohydrolase
MK616_RS02685	COG1917	Cupin 2, conserved barrel domain protein
MK616_RS02685	COG2207	Transcriptional regulator
MK616_RS02695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MK616_RS02700	COG0477	Major facilitator Superfamily
MK616_RS02740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MK616_RS02765	COG0351	phosphomethylpyrimidine kinase
MK616_RS02780	COG1064	alcohol dehydrogenase
MK616_RS02785	COG0789	Transcriptional regulator
MK616_RS02795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MK616_RS02810	COG2814	Major facilitator Superfamily
MK616_RS02815	COG1309	transcriptional regulator
MK616_RS02820	COG0697	spore germination
MK616_RS02825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MK616_RS02830	COG5577	PFAM Coat F domain
MK616_RS02840	COG1063	alcohol dehydrogenase
MK616_RS02845	COG5577	PFAM Coat F domain
MK616_RS02855	COG0738	Major facilitator superfamily
MK616_RS02875	COG4585	Histidine kinase
MK616_RS02880	COG2197	response regulator
MK616_RS02885	COG2409	Drug exporters of the RND superfamily
MK616_RS02890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MK616_RS02895	COG0488	(ABC) transporter
MK616_RS02900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MK616_RS02905	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MK616_RS02915	COG2814	Major facilitator Superfamily
MK616_RS02920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MK616_RS02930	COG0730	response to heat
MK616_RS02935	COG0456	acetyltransferase
MK616_RS02940	COG0789	Transcriptional regulator
MK616_RS02940	COG4978	Transcriptional regulator
MK616_RS02945	COG0697	spore germination
MK616_RS02950	COG1051	belongs to the nudix hydrolase family
MK616_RS02955	COG2226	methyltransferase
MK616_RS02960	COG0473	3-isopropylmalate dehydrogenase activity
MK616_RS02965	COG1802	Transcriptional regulator
MK616_RS02970	COG1819	glycosyl
MK616_RS02985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MK616_RS02995	COG1388	LysM domain
MK616_RS03000	COG2814	Major facilitator Superfamily
MK616_RS03005	COG2188	Transcriptional regulator
MK616_RS03010	COG2186	Transcriptional regulator
MK616_RS03015	COG2807	transmembrane transport
MK616_RS03020	COG2076	Multidrug Resistance protein
MK616_RS03025	COG2076	Multidrug Resistance protein
MK616_RS03030	COG1309	transcriptional regulator
MK616_RS03035	COG0531	amino acid
MK616_RS03045	COG3832	glyoxalase III activity
MK616_RS03050	COG0604	alcohol dehydrogenase
MK616_RS03055	COG2814	Major facilitator Superfamily
MK616_RS03095	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MK616_RS03100	COG0802	atpase or kinase
MK616_RS03105	COG1214	PFAM Peptidase M22, glycoprotease
MK616_RS03110	COG0456	acetyltransferase
MK616_RS03115	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MK616_RS03120	COG0488	(ABC) transporter
MK616_RS03135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MK616_RS03140	COG0805	protein transport
MK616_RS03150	COG1266	CAAX protease self-immunity
MK616_RS03175	COG0457	Tetratricopeptide repeat
MK616_RS03180	COG1063	alcohol dehydrogenase
MK616_RS03185	COG2211	Major facilitator Superfamily
MK616_RS03190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MK616_RS03200	COG1842	Phage shock protein A
MK616_RS03205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MK616_RS03210	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MK616_RS03215	COG4260	virion core protein, lumpy skin disease virus
MK616_RS03220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MK616_RS03220	COG2755	lipolytic protein G-D-S-L family
MK616_RS03230	COG1595	DNA-templated transcription, initiation
MK616_RS03235	COG1063	alcohol dehydrogenase
MK616_RS03240	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MK616_RS03245	COG0823	Involved in the tonB-independent uptake of proteins
MK616_RS03260	COG2132	Multicopper oxidase
MK616_RS03265	COG1113	amino acid transport
MK616_RS03270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MK616_RS03275	COG0714	Associated with various cellular activities
MK616_RS03280	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
MK616_RS03285	COG1305	Transglutaminase-like
MK616_RS03295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MK616_RS03315	COG2211	Major facilitator Superfamily
MK616_RS03330	COG2252	PERMEase
MK616_RS03335	COG3064	Membrane
MK616_RS03355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MK616_RS03360	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MK616_RS03365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MK616_RS03370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MK616_RS03375	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MK616_RS03390	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MK616_RS03400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MK616_RS03405	COG0138	bifunctional purine biosynthesis protein purh
MK616_RS03410	COG0151	Belongs to the GarS family
MK616_RS03425	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MK616_RS03430	COG1470	cell adhesion involved in biofilm formation
MK616_RS03435	COG4496	protein, YerC YecD
MK616_RS03440	COG0069	glutamate synthase activity
MK616_RS03450	COG0210	DNA helicase
MK616_RS03460	COG4851	CamS sex pheromone cAM373 precursor
MK616_RS03465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MK616_RS03470	COG1285	pathogenesis
MK616_RS03475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MK616_RS03495	COG1309	transcriptional regulator
MK616_RS03500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MK616_RS03505	COG1597	lipid kinase activity
MK616_RS03510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MK616_RS03525	COG1131	(ABC) transporter
MK616_RS03575	COG5444	nuclease activity
MK616_RS03605	COG3546	catalase activity
MK616_RS03610	COG0454	-acetyltransferase
MK616_RS03620	COG2323	membrane
MK616_RS03625	COG2329	Antibiotic biosynthesis monooxygenase
MK616_RS03630	COG0346	lactoylglutathione lyase activity
MK616_RS03635	COG1366	Belongs to the anti-sigma-factor antagonist family
MK616_RS03640	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MK616_RS03645	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MK616_RS03650	COG4208	sulfate ABC transporter
MK616_RS03660	COG5583	Uncharacterized small protein (DUF2292)
MK616_RS03665	COG0196	riboflavin kinase activity
MK616_RS03670	COG0670	Belongs to the BI1 family
MK616_RS03675	COG1846	Transcriptional regulator
MK616_RS03680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MK616_RS03690	COG2124	cytochrome p450
MK616_RS03690	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MK616_RS03705	COG1131	(ABC) transporter
MK616_RS03750	COG4106	trans-aconitate 2-methyltransferase activity
MK616_RS03755	COG1368	sulfuric ester hydrolase activity
MK616_RS03760	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MK616_RS03765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MK616_RS03770	COG1442	glycosyl transferase family 8
MK616_RS03775	COG1216	Glycosyl transferase, family 2
MK616_RS03780	COG1442	glycosyl transferase family 8
MK616_RS03785	COG2223	nitrite transmembrane transporter activity
MK616_RS03790	COG0531	amino acid
MK616_RS03795	COG1012	belongs to the aldehyde dehydrogenase family
MK616_RS03800	COG0840	transmembrane signaling receptor activity
MK616_RS03805	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS03810	COG0457	Tetratricopeptide repeat
MK616_RS03810	COG0463	Glycosyl transferase, family 2
MK616_RS03815	COG0488	(ABC) transporter
MK616_RS03820	COG0789	Transcriptional regulator
MK616_RS03825	COG2814	Major facilitator Superfamily
MK616_RS03830	COG0488	(ABC) transporter
MK616_RS03835	COG0513	Belongs to the DEAD box helicase family
MK616_RS03845	COG2130	NADP-dependent
MK616_RS03860	COG3866	Pectate lyase
MK616_RS03865	COG0471	metal ion transport
MK616_RS03885	COG2972	Histidine kinase
MK616_RS03885	COG0745	RESPONSE REGULATOR receiver
MK616_RS03895	COG3279	Response regulator of the LytR AlgR family
MK616_RS03905	COG3764	Sortase (surface protein transpeptidase)
MK616_RS03910	COG3290	protein histidine kinase activity
MK616_RS03915	COG4565	transcriptional regulatory protein
MK616_RS03920	COG3181	Tripartite tricarboxylate transporter family receptor
MK616_RS03925	COG2851	Citrate transporter
MK616_RS03930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MK616_RS03935	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
MK616_RS03945	COG2258	MOSC domain
MK616_RS03965	COG0024	Methionine aminopeptidase
MK616_RS03970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MK616_RS03970	COG1263	PTS System
MK616_RS03980	COG1368	sulfuric ester hydrolase activity
MK616_RS03990	COG0071	Belongs to the small heat shock protein (HSP20) family
MK616_RS04005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MK616_RS04005	COG1263	PTS System
MK616_RS04010	COG0366	Alpha amylase catalytic
MK616_RS04015	COG2188	Transcriptional regulator
MK616_RS04020	COG0778	Nitroreductase
MK616_RS04035	COG0737	Belongs to the 5'-nucleotidase family
MK616_RS04040	COG0693	protein deglycase activity
MK616_RS04045	COG1609	Transcriptional regulator
MK616_RS04060	COG2814	Major facilitator Superfamily
MK616_RS04070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MK616_RS04075	COG4980	gas vesicle protein
MK616_RS04080	COG1295	ribonuclease BN
MK616_RS04090	COG0477	Major facilitator Superfamily
MK616_RS04095	COG0387	Pfam Sodium calcium exchanger
MK616_RS04105	COG0668	transmembrane transport
MK616_RS04110	COG0535	radical SAM domain protein
MK616_RS04120	COG0726	polysaccharide deacetylase
MK616_RS04125	COG2084	Dehydrogenase
MK616_RS04135	COG0598	Magnesium transport protein CorA
MK616_RS04140	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MK616_RS04145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MK616_RS04160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MK616_RS04165	COG4637	Psort location Cytoplasmic, score
MK616_RS04170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MK616_RS04175	COG0022	dehydrogenase e1 component
MK616_RS04180	COG0508	dehydrogenase complex catalyzes the overall conversion of
MK616_RS04185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MK616_RS04190	COG3284	Transcriptional regulator
MK616_RS04200	COG1486	melibiose metabolic process
MK616_RS04205	COG1737	Transcriptional regulator
MK616_RS04210	COG1263	PTS System
MK616_RS04210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MK616_RS04215	COG1132	(ABC) transporter
MK616_RS04220	COG1132	(ABC) transporter
MK616_RS04225	COG2259	Doxx family
MK616_RS04230	COG2514	catechol 2,3-dioxygenase activity
MK616_RS04240	COG1695	Transcriptional regulator
MK616_RS04245	COG2249	NAD(P)H dehydrogenase (quinone) activity
MK616_RS04250	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
MK616_RS04255	COG3848	Pyruvate phosphate dikinase
MK616_RS04255	COG0574	Belongs to the PEP-utilizing enzyme family
MK616_RS04260	COG2732	(Barnase) inhibitor
MK616_RS04265	COG2318	DinB family
MK616_RS04270	COG2814	Major facilitator Superfamily
MK616_RS04275	COG1846	Transcriptional regulator
MK616_RS04280	COG0392	lysyltransferase activity
MK616_RS04280	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MK616_RS04285	COG0384	phenazine biosynthesis protein PhzF
MK616_RS04290	COG0778	Nitroreductase
MK616_RS04305	COG1090	epimerase
MK616_RS04320	COG2814	Major facilitator Superfamily
MK616_RS04330	COG3591	Belongs to the peptidase S1B family
MK616_RS04345	COG3103	Sh3 type 3 domain protein
MK616_RS04350	COG5658	integral membrane protein
MK616_RS04355	COG0596	Alpha beta hydrolase
MK616_RS04360	COG0463	Glycosyl transferase, family 2
MK616_RS04365	COG4485	Bacterial membrane protein, YfhO
MK616_RS04370	COG1988	membrane-bound metal-dependent
MK616_RS04375	COG1194	a g-specific adenine glycosylase
MK616_RS04385	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS04405	COG1132	(ABC) transporter
MK616_RS04410	COG4129	membrane
MK616_RS04420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MK616_RS04425	COG0735	belongs to the Fur family
MK616_RS04540	COG3340	Belongs to the peptidase S51 family
MK616_RS04550	COG0277	FAD linked oxidase domain protein
MK616_RS04560	COG0747	negative chemotaxis
MK616_RS04565	COG0601	transmembrane transport
MK616_RS04570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MK616_RS04575	COG0444	Belongs to the ABC transporter superfamily
MK616_RS04580	COG4608	Belongs to the ABC transporter superfamily
MK616_RS04585	COG0753	catalase activity
MK616_RS04595	COG1116	anion transmembrane transporter activity
MK616_RS04600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MK616_RS04605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MK616_RS04625	COG1476	TRANSCRIPTIONal
MK616_RS04635	COG3382	B3 4 domain protein
MK616_RS04640	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MK616_RS04650	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MK616_RS04655	COG0789	Transcriptional regulator
MK616_RS04660	COG1664	Polymer-forming cytoskeletal
MK616_RS04665	COG1664	Polymer-forming cytoskeletal
MK616_RS04670	COG2766	serine protein kinase
MK616_RS04680	COG1846	Transcriptional regulator
MK616_RS04685	COG1566	PFAM secretion protein HlyD family protein
MK616_RS04690	COG2814	Major facilitator Superfamily
MK616_RS04695	COG0655	NAD(P)H dehydrogenase (quinone) activity
MK616_RS04710	COG1725	Transcriptional regulator
MK616_RS04715	COG1131	(ABC) transporter
MK616_RS04720	COG1131	(ABC) transporter
MK616_RS04725	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MK616_RS04730	COG1278	Cold shock
MK616_RS04735	COG1464	Belongs to the NlpA lipoprotein family
MK616_RS04740	COG3706	GGDEF domain
MK616_RS04745	COG1823	symporter activity
MK616_RS04765	COG5577	PFAM Coat F domain
MK616_RS04770	COG0737	Belongs to the 5'-nucleotidase family
MK616_RS04770	COG1525	nuclease
MK616_RS04770	COG4085	toxin activity
MK616_RS04775	COG3764	Sortase (surface protein transpeptidase)
MK616_RS04780	COG0564	pseudouridine synthase activity
MK616_RS04790	COG0517	IMP dehydrogenase activity
MK616_RS04795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MK616_RS04800	COG3153	acetyltransferase
MK616_RS04800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MK616_RS04805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MK616_RS04810	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MK616_RS04815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MK616_RS04825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MK616_RS04830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MK616_RS04835	COG2203	Gaf domain
MK616_RS04835	COG4585	Histidine kinase
MK616_RS04840	COG2197	response regulator
MK616_RS04845	COG0431	NADPH-dependent FMN reductase
MK616_RS04860	COG0791	NLP P60 protein
MK616_RS04860	COG1388	LysM domain
MK616_RS04865	COG1959	2 iron, 2 sulfur cluster binding
MK616_RS04875	COG2719	SpoVR family
MK616_RS04880	COG1785	Belongs to the alkaline phosphatase family
MK616_RS04885	COG1388	LysM domain
MK616_RS04885	COG0791	NLP P60 protein
MK616_RS04890	COG0583	DNA-binding transcription factor activity
MK616_RS04895	COG0372	Belongs to the citrate synthase family
MK616_RS04900	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS04905	COG0531	amino acid
MK616_RS04910	COG0733	neurotransmitter:sodium symporter activity
MK616_RS04925	COG1595	DNA-templated transcription, initiation
MK616_RS04930	COG0204	Acyl-transferase
MK616_RS04935	COG1253	flavin adenine dinucleotide binding
MK616_RS04940	COG0789	Transcriptional regulator
MK616_RS04945	COG0436	Aminotransferase
MK616_RS04950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MK616_RS04955	COG1253	flavin adenine dinucleotide binding
MK616_RS04960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MK616_RS04965	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MK616_RS04970	COG0584	glycerophosphoryl diester phosphodiesterase
MK616_RS04980	COG0668	transmembrane transport
MK616_RS04985	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MK616_RS04990	COG0726	polysaccharide deacetylase
MK616_RS04995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MK616_RS05000	COG3226	Transcriptional regulator
MK616_RS05010	COG0589	response to stress
MK616_RS05015	COG1132	(ABC) transporter
MK616_RS05020	COG1132	(ABC) transporter
MK616_RS05035	COG0702	epimerase
MK616_RS05055	COG0189	ligase activity
MK616_RS05060	COG0189	ligase activity
MK616_RS05075	COG4335	DNA alkylation repair
MK616_RS05080	COG0561	phosphatase activity
MK616_RS05085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MK616_RS05095	COG0475	glutathione-regulated potassium exporter activity
MK616_RS05100	COG0490	domain, Protein
MK616_RS05110	COG1024	Enoyl-CoA hydratase
MK616_RS05120	COG4152	abc transporter atp-binding protein
MK616_RS05125	COG1668	transmembrane transport
MK616_RS05130	COG0420	3'-5' exonuclease activity
MK616_RS05135	COG4717	serine-type aminopeptidase activity
MK616_RS05150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MK616_RS05185	COG4980	gas vesicle protein
MK616_RS05200	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MK616_RS05205	COG0537	adenosine 5'-monophosphoramidase activity
MK616_RS05210	COG1131	(ABC) transporter
MK616_RS05215	COG4473	ABC transporter
MK616_RS05225	COG1473	amidohydrolase
MK616_RS05230	COG3069	C4-dicarboxylate transmembrane transporter activity
MK616_RS05235	COG2329	Antibiotic biosynthesis monooxygenase
MK616_RS05240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MK616_RS05250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MK616_RS05255	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MK616_RS05260	COG1309	transcriptional regulator
MK616_RS05265	COG1511	domain protein
MK616_RS05270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MK616_RS05280	COG1363	Peptidase, m42
MK616_RS05285	COG1301	dicarboxylic acid transport
MK616_RS05295	COG1234	tRNA 3'-trailer cleavage
MK616_RS05300	COG0095	Lipoate-protein ligase
MK616_RS05305	COG0702	epimerase
MK616_RS05310	COG0318	PFAM AMP-dependent synthetase and ligase
MK616_RS05320	COG0501	Belongs to the peptidase M48B family
MK616_RS05325	COG1404	Belongs to the peptidase S8 family
MK616_RS05330	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MK616_RS05335	COG0406	alpha-ribazole phosphatase activity
MK616_RS05340	COG0183	Belongs to the thiolase family
MK616_RS05345	COG0318	PFAM AMP-dependent synthetase and ligase
MK616_RS05350	COG1268	BioY protein
MK616_RS05355	COG0840	transmembrane signaling receptor activity
MK616_RS05360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MK616_RS05360	COG0723	plastoquinol--plastocyanin reductase activity
MK616_RS05365	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS05375	COG4903	ComK protein
MK616_RS05385	COG5646	InterPro IPR014922
MK616_RS05410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MK616_RS05425	COG0398	Pfam SNARE associated Golgi protein
MK616_RS05430	COG0681	Belongs to the peptidase S26 family
MK616_RS05435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MK616_RS05440	COG1846	Transcriptional regulator
MK616_RS05445	COG3180	Ammonia monooxygenase
MK616_RS05450	COG2814	Major facilitator Superfamily
MK616_RS05460	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
MK616_RS05480	COG0420	3'-5' exonuclease activity
MK616_RS05485	COG0419	ATPase involved in DNA repair
MK616_RS05490	COG1403	HNH endonuclease
MK616_RS05530	COG0179	Fumarylacetoacetate (FAA) hydrolase
MK616_RS05545	COG0367	asparagine synthase
MK616_RS05550	COG1562	ergosterol biosynthetic process
MK616_RS05555	COG0534	Mate efflux family protein
MK616_RS05560	COG1917	Cupin 2, conserved barrel domain protein
MK616_RS05560	COG2207	Transcriptional regulator
MK616_RS05565	COG1609	Transcriptional regulator
MK616_RS05570	COG0673	inositol 2-dehydrogenase activity
MK616_RS05575	COG2318	DinB family
MK616_RS05580	COG1357	PFAM Pentapeptide repeats (8 copies)
MK616_RS05585	COG2153	protein acetylation
MK616_RS05590	COG0646	methionine synthase
MK616_RS05590	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MK616_RS05600	COG2996	Protein conserved in bacteria
MK616_RS05605	COG1744	ABC transporter substrate-binding protein PnrA-like
MK616_RS05610	COG0840	transmembrane signaling receptor activity
MK616_RS05615	COG2124	cytochrome p450
MK616_RS05625	COG1307	EDD domain protein, DegV family
MK616_RS05630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MK616_RS05650	COG0561	phosphatase activity
MK616_RS05655	COG1073	alpha beta
MK616_RS05660	COG2151	metal-sulfur cluster biosynthetic enzyme
MK616_RS05670	COG0277	FAD linked oxidase domain protein
MK616_RS05675	COG2271	Major facilitator Superfamily
MK616_RS05685	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MK616_RS05695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MK616_RS05700	COG0505	Belongs to the CarA family
MK616_RS05705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MK616_RS05710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MK616_RS05725	COG2267	carboxylic ester hydrolase activity
MK616_RS05735	COG1744	ABC transporter substrate-binding protein PnrA-like
MK616_RS05750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MK616_RS05755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MK616_RS05760	COG5504	Zn-dependent protease
MK616_RS05765	COG0444	Belongs to the ABC transporter superfamily
MK616_RS05770	COG4608	Belongs to the ABC transporter superfamily
MK616_RS05780	COG0601	transmembrane transport
MK616_RS05785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MK616_RS05795	COG0180	Tryptophanyl-tRNA synthetase
MK616_RS05800	COG4166	transmembrane transport
MK616_RS05805	COG0601	transmembrane transport
MK616_RS05810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MK616_RS05815	COG0444	Belongs to the ABC transporter superfamily
MK616_RS05820	COG4608	Belongs to the ABC transporter superfamily
MK616_RS05830	COG0456	acetyltransferase
MK616_RS05835	COG1393	Belongs to the ArsC family
MK616_RS05840	COG0861	Integral membrane protein TerC family
MK616_RS05845	COG4862	establishment of competence for transformation
MK616_RS05850	COG4469	Competence protein
MK616_RS05855	COG1164	Oligoendopeptidase f
MK616_RS05865	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MK616_RS05870	COG2346	COG2346, Truncated hemoglobins
MK616_RS05875	COG0741	lytic transglycosylase activity
MK616_RS05880	COG4116	CYTH
MK616_RS05890	COG2357	RelA SpoT domain protein
MK616_RS05895	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MK616_RS05900	COG0564	pseudouridine synthase activity
MK616_RS05910	COG0475	glutathione-regulated potassium exporter activity
MK616_RS05910	COG0569	domain protein
MK616_RS05915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MK616_RS05920	COG0352	thiamine-phosphate diphosphorylase activity
MK616_RS05925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MK616_RS05930	COG2104	thiamine diphosphate biosynthetic process
MK616_RS05940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MK616_RS05945	COG0351	phosphomethylpyrimidine kinase
MK616_RS05950	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MK616_RS06005	COG0210	DNA helicase
MK616_RS06025	COG1131	(ABC) transporter
MK616_RS06035	COG2153	protein acetylation
MK616_RS06045	COG2382	esterase
MK616_RS06050	COG0626	cystathionine gamma-synthase activity
MK616_RS06055	COG0626	cystathionine gamma-synthase activity
MK616_RS06075	COG4974	Belongs to the 'phage' integrase family
MK616_RS06210	COG5444	nuclease activity
MK616_RS06230	COG0135	phosphoribosylanthranilate isomerase activity
MK616_RS06240	COG0346	lactoylglutathione lyase activity
MK616_RS06245	COG2367	Beta-lactamase
MK616_RS06250	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
MK616_RS06260	COG1846	Transcriptional regulator
MK616_RS06270	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MK616_RS06275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MK616_RS06280	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MK616_RS06285	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MK616_RS06285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MK616_RS06290	COG1447	Phosphotransferase system cellobiose-specific component IIA
MK616_RS06320	COG1285	pathogenesis
MK616_RS06335	COG2205	protein histidine kinase activity
MK616_RS06345	COG3383	formate dehydrogenase (NAD+) activity
MK616_RS06350	COG2427	Protein of unknown function (DUF1641)
MK616_RS06355	COG2124	cytochrome p450
MK616_RS06360	COG1819	glycosyl
MK616_RS06370	COG1587	Uroporphyrinogen-III synthase
MK616_RS06375	COG0390	transport system, permease component
MK616_RS06380	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MK616_RS06385	COG0697	spore germination
MK616_RS06390	COG4297	protein containing double-stranded beta helix domain
MK616_RS06400	COG1252	NADH dehydrogenase
MK616_RS06410	COG2211	Major facilitator Superfamily
MK616_RS06415	COG1609	Transcriptional regulator
MK616_RS06420	COG0246	Mannitol dehydrogenase
MK616_RS06425	COG2721	sulfolactate sulfo-lyase activity
MK616_RS06430	COG0730	response to heat
MK616_RS06435	COG2318	DinB family
MK616_RS06440	COG0457	Tetratricopeptide repeat
MK616_RS06450	COG1388	LysM domain
MK616_RS06450	COG3409	Peptidoglycan-binding domain 1 protein
MK616_RS06450	COG5632	N-Acetylmuramoyl-L-alanine amidase
MK616_RS06460	COG4195	phage-related replication protein
MK616_RS06465	COG3546	catalase activity
MK616_RS06470	COG2856	Zn peptidase
MK616_RS06475	COG1396	sequence-specific DNA binding
MK616_RS06485	COG1522	sequence-specific DNA binding
MK616_RS06490	COG1484	DNA-dependent DNA replication
MK616_RS06510	COG1595	DNA-templated transcription, initiation
MK616_RS06515	COG3728	DNA packaging
MK616_RS06515	COG5484	DNA packaging
MK616_RS06520	COG1783	phage Terminase large subunit
MK616_RS06525	COG5518	Phage portal protein
MK616_RS06530	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MK616_RS06535	COG4653	Phage capsid family
MK616_RS06585	COG3953	SLT domain
MK616_RS06585	COG5412	phage tail tape measure protein
MK616_RS06585	COG3953	SLT domain
MK616_RS06585	COG5412	phage tail tape measure protein
MK616_RS06585	COG3953	SLT domain
MK616_RS06585	COG5412	phage tail tape measure protein
MK616_RS06590	COG1652	LysM domain
MK616_RS06595	COG4193	domain, Protein
MK616_RS06605	COG3628	GPW Gp25 family protein
MK616_RS06610	COG3299	homolog of phage Mu protein gp47
MK616_RS06615	COG3778	Protein conserved in bacteria
MK616_RS06660	COG3409	Peptidoglycan-binding domain 1 protein
MK616_RS06660	COG5632	N-Acetylmuramoyl-L-alanine amidase
MK616_RS06680	COG0306	phosphate transporter
MK616_RS06685	COG1392	Phosphate transport regulator
MK616_RS06690	COG0531	amino acid
MK616_RS06695	COG0346	lactoylglutathione lyase activity
MK616_RS06700	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MK616_RS06705	COG0463	Glycosyl transferase, family 2
MK616_RS06715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MK616_RS06720	COG0477	Major facilitator Superfamily
MK616_RS06725	COG2362	D-Aminopeptidase
MK616_RS06730	COG0601	transmembrane transport
MK616_RS06735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MK616_RS06740	COG0444	Belongs to the ABC transporter superfamily
MK616_RS06745	COG4166	transmembrane transport
MK616_RS06750	COG1619	proteins homologs of microcin C7 resistance protein MccF
MK616_RS06755	COG4948	Mandelate Racemase Muconate Lactonizing
MK616_RS06760	COG0791	NLP P60 protein
MK616_RS06765	COG4608	Belongs to the ABC transporter superfamily
MK616_RS06770	COG2706	6-phosphogluconolactonase activity
MK616_RS06775	COG1834	amidinotransferase
MK616_RS06780	COG1607	acyl-coa hydrolase
MK616_RS06785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MK616_RS06790	COG2076	Multidrug Resistance protein
MK616_RS06795	COG2076	Multidrug Resistance protein
MK616_RS06800	COG0788	formyltetrahydrofolate deformylase activity
MK616_RS06805	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MK616_RS06815	COG1764	response to oxidative stress
MK616_RS06820	COG1846	Transcriptional regulator
MK616_RS06825	COG1764	response to oxidative stress
MK616_RS06840	COG0457	Tetratricopeptide repeat
MK616_RS06840	COG0463	Glycosyl transferase, family 2
MK616_RS06850	COG2814	Major facilitator Superfamily
MK616_RS06855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MK616_RS06865	COG1404	Belongs to the peptidase S8 family
MK616_RS06870	COG1366	Belongs to the anti-sigma-factor antagonist family
MK616_RS06875	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MK616_RS06880	COG1122	ATPase activity
MK616_RS06885	COG4721	ABC-type cobalt transport system, permease component
MK616_RS06890	COG1388	LysM domain
MK616_RS06890	COG3858	chitin binding
MK616_RS06900	COG2239	Acts as a magnesium transporter
MK616_RS06905	COG0789	Transcriptional regulator
MK616_RS06920	COG1846	Transcriptional regulator
MK616_RS06925	COG0726	polysaccharide deacetylase
MK616_RS06930	COG1793	dna ligase
MK616_RS06930	COG3285	dna ligase
MK616_RS06935	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MK616_RS06940	COG0586	Pfam SNARE associated Golgi protein
MK616_RS06950	COG1191	sigma factor activity
MK616_RS06975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MK616_RS06990	COG3594	Acyltransferase
MK616_RS06995	COG5002	protein histidine kinase activity
MK616_RS07000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MK616_RS07020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MK616_RS07025	COG0436	Aminotransferase
MK616_RS07055	COG3852	Histidine kinase
MK616_RS07060	COG1846	Transcriptional regulator
MK616_RS07065	COG1360	Flagellar Motor Protein
MK616_RS07070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MK616_RS07075	COG0542	response to heat
MK616_RS07080	COG3949	Membrane
MK616_RS07095	COG0720	synthase
MK616_RS07100	COG0602	queuosine metabolic process
MK616_RS07105	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MK616_RS07110	COG1733	regulation of RNA biosynthetic process
MK616_RS07115	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS07130	COG4873	Protein conserved in bacteria
MK616_RS07140	COG3773	Cell wall hydrolase
MK616_RS07145	COG2244	polysaccharide biosynthetic process
MK616_RS07150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MK616_RS07155	COG2217	Heavy metal translocating P-type atpase
MK616_RS07160	COG0006	proline dipeptidase activity
MK616_RS07165	COG1609	Transcriptional regulator
MK616_RS07170	COG3711	transcriptional antiterminator
MK616_RS07175	COG1263	PTS System
MK616_RS07175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MK616_RS07175	COG2190	(PTS) system
MK616_RS07180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MK616_RS07185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MK616_RS07195	COG1533	DNA photolyase activity
MK616_RS07200	COG0840	transmembrane signaling receptor activity
MK616_RS07205	COG2084	Dehydrogenase
MK616_RS07210	COG2340	Cysteine-rich secretory protein family
MK616_RS07215	COG0768	penicillin binding
MK616_RS07220	COG4191	Histidine kinase
MK616_RS07225	COG0436	Aminotransferase
MK616_RS07235	COG0784	Response regulator, receiver
MK616_RS07235	COG0835	chemotaxis
MK616_RS07245	COG2814	Major facilitator Superfamily
MK616_RS07250	COG1376	ErfK ybiS ycfS ynhG family protein
MK616_RS07255	COG1408	metallophosphoesterase
MK616_RS07260	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS07270	COG2200	EAL domain
MK616_RS07275	COG4703	Protein of unknown function (DUF1797)
MK616_RS07280	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
MK616_RS07290	COG0517	IMP dehydrogenase activity
MK616_RS07295	COG0583	DNA-binding transcription factor activity
MK616_RS07300	COG0716	FMN binding
MK616_RS07310	COG0716	FMN binding
MK616_RS07330	COG0668	transmembrane transport
MK616_RS07335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MK616_RS07355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MK616_RS07360	COG0303	'Molybdopterin
MK616_RS07365	COG1763	Mo-molybdopterin cofactor biosynthetic process
MK616_RS07370	COG0314	molybdopterin synthase activity
MK616_RS07375	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MK616_RS07385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MK616_RS07390	COG1136	(ABC) transporter
MK616_RS07395	COG0577	efflux transmembrane transporter activity
MK616_RS07400	COG1349	DNA-binding transcription factor activity
MK616_RS07405	COG1105	Belongs to the carbohydrate kinase PfkB family
MK616_RS07410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MK616_RS07410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MK616_RS07410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MK616_RS07415	COG0681	Belongs to the peptidase S26 family
MK616_RS07425	COG0488	(ABC) transporter
MK616_RS07430	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MK616_RS07435	COG2309	aminopeptidase activity
MK616_RS07445	COG1077	Cell shape determining protein MreB Mrl
MK616_RS07450	COG2002	toxin-antitoxin pair type II binding
MK616_RS07455	COG3852	Histidine kinase
MK616_RS07460	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
MK616_RS07460	COG2105	PFAM AIG2 family protein
MK616_RS07465	COG0569	domain protein
MK616_RS07475	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MK616_RS07485	COG0561	phosphatase activity
MK616_RS07490	COG0242	peptide deformylase activity
MK616_RS07500	COG0497	DNA recombination
MK616_RS07510	COG4221	oxidoreductase activity
MK616_RS07510	COG3321	synthase
MK616_RS07510	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS07510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS07515	COG4221	oxidoreductase activity
MK616_RS07515	COG3321	synthase
MK616_RS07515	COG0300	oxidoreductase activity
MK616_RS07515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MK616_RS07520	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS07520	COG3321	synthase
MK616_RS07520	COG4221	oxidoreductase activity
MK616_RS07520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS07525	COG3321	synthase
MK616_RS07525	COG0300	oxidoreductase activity
MK616_RS07525	COG4221	oxidoreductase activity
MK616_RS07525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MK616_RS07530	COG4221	oxidoreductase activity
MK616_RS07530	COG3321	synthase
MK616_RS07530	COG0300	oxidoreductase activity
MK616_RS07530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MK616_RS07535	COG3321	synthase
MK616_RS07535	COG4221	oxidoreductase activity
MK616_RS07535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MK616_RS07535	COG0300	oxidoreductase activity
MK616_RS07540	COG4221	oxidoreductase activity
MK616_RS07540	COG3321	synthase
MK616_RS07540	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS07540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS07545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MK616_RS07550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MK616_RS07555	COG0022	dehydrogenase e1 component
MK616_RS07560	COG0508	dehydrogenase complex catalyzes the overall conversion of
MK616_RS07565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MK616_RS07570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MK616_RS07585	COG1982	Orn Lys Arg decarboxylase major
MK616_RS07605	COG0483	inositol monophosphate 1-phosphatase activity
MK616_RS07615	COG3227	Zinc metalloprotease (Elastase)
MK616_RS07630	COG1595	DNA-templated transcription, initiation
MK616_RS07650	COG1217	gtp-binding protein TYPA
MK616_RS07660	COG4896	Protein conserved in bacteria
MK616_RS07670	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MK616_RS07675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MK616_RS07680	COG2066	Belongs to the glutaminase family
MK616_RS07690	COG0772	Belongs to the SEDS family
MK616_RS07695	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MK616_RS07710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MK616_RS07710	COG2010	Cytochrome c
MK616_RS07715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MK616_RS07720	COG1845	cytochrome c oxidase, subunit III
MK616_RS07725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MK616_RS07730	COG3336	cytochrome c oxidase
MK616_RS07740	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MK616_RS07745	COG2340	Cysteine-rich secretory protein family
MK616_RS07760	COG3679	Belongs to the UPF0342 family
MK616_RS07770	COG0742	ribosomal rna small subunit methyltransferase
MK616_RS07780	COG3314	Sporulation integral membrane protein YlbJ
MK616_RS07785	COG1752	Esterase of the alpha-beta hydrolase superfamily
MK616_RS07790	COG3480	Lon protease (S16) C-terminal proteolytic domain
MK616_RS07800	COG1399	metal-binding, possibly nucleic acid-binding protein
MK616_RS07820	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MK616_RS07840	COG4839	cell division protein FtsL
MK616_RS07845	COG0768	penicillin binding
MK616_RS07850	COG0768	penicillin binding
MK616_RS07870	COG0772	Belongs to the SEDS family
MK616_RS07885	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MK616_RS07890	COG0849	cell division
MK616_RS07895	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MK616_RS07900	COG4412	M6 family metalloprotease domain protein
MK616_RS07900	COG1404	Belongs to the peptidase S8 family
MK616_RS07910	COG1191	sigma factor activity
MK616_RS07915	COG1191	sigma factor activity
MK616_RS07920	COG1119	ATPase activity
MK616_RS07925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MK616_RS07930	COG1873	PFAM PRC-barrel domain
MK616_RS07935	COG1496	oxidoreductase activity
MK616_RS07940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MK616_RS07950	COG0762	integral membrane protein
MK616_RS07955	COG2302	S4 RNA-binding domain
MK616_RS07960	COG3599	regulation of cell shape
MK616_RS07965	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MK616_RS07970	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MK616_RS07980	COG0564	pseudouridine synthase activity
MK616_RS07990	COG2233	PERMEase
MK616_RS08000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MK616_RS08005	COG0505	Belongs to the CarA family
MK616_RS08010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MK616_RS08025	COG0284	orotidine-5'-phosphate decarboxylase activity
MK616_RS08030	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MK616_RS08040	COG0306	phosphate transporter
MK616_RS08055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MK616_RS08060	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
MK616_RS08065	COG1648	precorrin-2 dehydrogenase activity
MK616_RS08080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MK616_RS08085	COG1561	YicC-like family, N-terminal region
MK616_RS08095	COG0194	GDP metabolic process
MK616_RS08105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MK616_RS08110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MK616_RS08115	COG0242	peptide deformylase activity
MK616_RS08125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MK616_RS08125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MK616_RS08135	COG0631	protein serine/threonine phosphatase activity
MK616_RS08140	COG0515	serine threonine protein kinase
MK616_RS08140	COG2815	serine threonine protein kinase
MK616_RS08150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MK616_RS08155	COG1564	THIamine pyrophosphokinase
MK616_RS08170	COG1302	Protein conserved in bacteria
MK616_RS08175	COG1461	Dihydroxyacetone kinase
MK616_RS08180	COG1760	l-serine dehydratase
MK616_RS08185	COG1760	l-serine dehydratase
MK616_RS08190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MK616_RS08205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MK616_RS08210	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS08225	COG1196	nuclear chromosome segregation
MK616_RS08230	COG0552	protein localization to endoplasmic reticulum
MK616_RS08245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MK616_RS08255	COG1837	Belongs to the UPF0109 family
MK616_RS08280	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MK616_RS08295	COG2257	FlhB HrpN YscU SpaS Family
MK616_RS08305	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MK616_RS08310	COG0758	DNA mediated transformation
MK616_RS08315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MK616_RS08325	COG4974	Belongs to the 'phage' integrase family
MK616_RS08345	COG1815	bacterial-type flagellum-dependent cell motility
MK616_RS08350	COG1558	bacterial-type flagellum-dependent cell motility
MK616_RS08355	COG1677	Flagellar hook-basal body complex protein FliE
MK616_RS08360	COG1766	The M ring may be actively involved in energy transduction
MK616_RS08365	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MK616_RS08370	COG1317	bacterial-type flagellum organization
MK616_RS08375	COG1157	protein secretion by the type III secretion system
MK616_RS08380	COG2882	bacterial-type flagellum organization
MK616_RS08385	COG3334	PFAM MgtE intracellular
MK616_RS08390	COG3144	bacterial-type flagellum assembly
MK616_RS08395	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MK616_RS08400	COG4786	Flagellar basal body rod
MK616_RS08405	COG1582	Flagellar protein (FlbD)
MK616_RS08410	COG1580	Controls the rotational direction of flagella during chemotaxis
MK616_RS08415	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MK616_RS08420	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MK616_RS08420	COG1776	CheC inhibitor of MCP methylation
MK616_RS08425	COG2201	protein-glutamate methylesterase activity
MK616_RS08430	COG3190	flagellar
MK616_RS08435	COG1338	Plays a role in the flagellum-specific transport system
MK616_RS08440	COG1987	bacterial-type flagellum assembly
MK616_RS08445	COG1684	flagellar biosynthetic protein fliR
MK616_RS08450	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MK616_RS08455	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MK616_RS08460	COG1419	protein localization to endoplasmic reticulum
MK616_RS08465	COG0455	bacterial-type flagellum organization
MK616_RS08470	COG2201	protein-glutamate methylesterase activity
MK616_RS08475	COG0643	Histidine kinase
MK616_RS08475	COG2198	Histidine kinase
MK616_RS08480	COG0835	chemotaxis
MK616_RS08485	COG1776	CheC inhibitor of MCP methylation
MK616_RS08495	COG1191	sigma factor activity
MK616_RS08525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MK616_RS08530	COG4589	Belongs to the CDS family
MK616_RS08540	COG0750	zinc metalloprotease
MK616_RS08560	COG0195	Participates in both transcription termination and antitermination
MK616_RS08565	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MK616_RS08570	COG1358	cellular component organization or biogenesis
MK616_RS08580	COG1550	Protein conserved in bacteria
MK616_RS08595	COG0196	riboflavin kinase activity
MK616_RS08610	COG0726	polysaccharide deacetylase
MK616_RS08615	COG0612	Peptidase, M16
MK616_RS08620	COG1873	PFAM PRC-barrel domain
MK616_RS08625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MK616_RS08630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MK616_RS08635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MK616_RS08640	COG0527	aspartate kinase activity
MK616_RS08650	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MK616_RS08655	COG0740	serine-type endopeptidase activity
MK616_RS08665	COG1674	ftsk spoiiie
MK616_RS08665	COG4980	gas vesicle protein
MK616_RS08670	COG2188	Transcriptional regulator
MK616_RS08675	COG2814	Major facilitator Superfamily
MK616_RS08680	COG1846	Transcriptional regulator
MK616_RS08685	COG2409	Drug exporters of the RND superfamily
MK616_RS08685	COG1033	growth of symbiont in host cell
MK616_RS08690	COG0612	Peptidase, M16
MK616_RS08695	COG0612	Peptidase, M16
MK616_RS08700	COG0300	oxidoreductase activity
MK616_RS08715	COG1426	Protein conserved in bacteria
MK616_RS08720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MK616_RS08735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MK616_RS08745	COG1692	metallophosphoesterase
MK616_RS08750	COG2359	stage V sporulation protein S
MK616_RS08770	COG4550	Control of competence regulator ComK, YlbF/YmcA
MK616_RS08835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MK616_RS08840	COG3425	synthase
MK616_RS08845	COG1024	Enoyl-CoA hydratase
MK616_RS08850	COG1024	Enoyl-CoA hydratase
MK616_RS08855	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS08855	COG3321	synthase
MK616_RS08855	COG0318	PFAM AMP-dependent synthetase and ligase
MK616_RS08855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS08855	COG0300	oxidoreductase activity
MK616_RS08860	COG0300	oxidoreductase activity
MK616_RS08860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MK616_RS08860	COG3321	synthase
MK616_RS08860	COG4221	oxidoreductase activity
MK616_RS08865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MK616_RS08865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MK616_RS08865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS08865	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS08865	COG3321	synthase
MK616_RS08865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MK616_RS08865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MK616_RS08865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS08865	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS08865	COG3321	synthase
MK616_RS08870	COG3321	synthase
MK616_RS08870	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS08870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS08870	COG4221	oxidoreductase activity
MK616_RS08875	COG3321	synthase
MK616_RS08875	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
MK616_RS08875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MK616_RS08875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MK616_RS08880	COG2124	cytochrome p450
MK616_RS08885	COG3209	COG3209 Rhs family protein
MK616_RS08890	COG3619	membrane
MK616_RS08900	COG1404	Belongs to the peptidase S8 family
MK616_RS08910	COG4195	phage-related replication protein
MK616_RS08915	COG1764	response to oxidative stress
MK616_RS08925	COG2076	Multidrug Resistance protein
MK616_RS08965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MK616_RS08970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MK616_RS08975	COG4112	unkown
MK616_RS08980	COG0860	N-Acetylmuramoyl-L-alanine amidase
MK616_RS08985	COG0464	growth
MK616_RS08990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MK616_RS08995	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MK616_RS09000	COG0789	Transcriptional regulator
MK616_RS09005	COG0174	glutamine synthetase
MK616_RS09035	COG2211	Major facilitator Superfamily
MK616_RS09040	COG3507	Belongs to the glycosyl hydrolase 43 family
MK616_RS09055	COG1070	Carbohydrate kinase
MK616_RS09060	COG3848	Pyruvate phosphate dikinase
MK616_RS09060	COG0574	Belongs to the PEP-utilizing enzyme family
MK616_RS09080	COG2378	regulation of single-species biofilm formation
MK616_RS09085	COG2318	DinB family
MK616_RS09090	COG1064	alcohol dehydrogenase
MK616_RS09095	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MK616_RS09095	COG4451	ribulose bisphosphate carboxylase, small
MK616_RS09110	COG0456	acetyltransferase
MK616_RS09115	COG5444	nuclease activity
MK616_RS09150	COG3397	chitin binding
MK616_RS09170	COG5434	Belongs to the glycosyl hydrolase 28 family
MK616_RS09175	COG0756	dUTP diphosphatase activity
MK616_RS09180	COG4195	phage-related replication protein
MK616_RS09215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MK616_RS09225	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MK616_RS09245	COG0785	Cytochrome C biogenesis protein
MK616_RS09250	COG2201	protein-glutamate methylesterase activity
MK616_RS09255	COG4846	Membrane protein involved in cytochrome C biogenesis
MK616_RS09265	COG0071	Belongs to the small heat shock protein (HSP20) family
MK616_RS09280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MK616_RS09285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MK616_RS09305	COG0824	Thioesterase
MK616_RS09315	COG4841	protein insertion into membrane
MK616_RS09325	COG1832	CoA-binding protein
MK616_RS09330	COG0187	DNA topoisomerase II activity
MK616_RS09335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MK616_RS09345	COG1115	amino acid carrier protein
MK616_RS09355	COG1063	alcohol dehydrogenase
MK616_RS09360	COG0800	Aldolase
MK616_RS09365	COG1312	Catalyzes the dehydration of D-mannonate
MK616_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS09375	COG1609	Transcriptional regulator
MK616_RS09380	COG2271	Major facilitator Superfamily
MK616_RS09415	COG0457	Tetratricopeptide repeat
MK616_RS09445	COG1136	(ABC) transporter
MK616_RS09445	COG0577	efflux transmembrane transporter activity
MK616_RS09475	COG2205	protein histidine kinase activity
MK616_RS09480	COG0745	RESPONSE REGULATOR receiver
MK616_RS09490	COG3507	Belongs to the glycosyl hydrolase 43 family
MK616_RS09515	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS09520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MK616_RS09525	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MK616_RS09530	COG2610	gluconate transmembrane transporter activity
MK616_RS09535	COG2124	cytochrome p450
MK616_RS09555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MK616_RS09565	COG2246	polysaccharide biosynthetic process
MK616_RS09570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MK616_RS09575	COG0586	Pfam SNARE associated Golgi protein
MK616_RS09580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MK616_RS09585	COG1024	Enoyl-CoA hydratase
MK616_RS09590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MK616_RS09595	COG0511	ligase activity, forming carbon-carbon bonds
MK616_RS09600	COG0439	Biotin carboxylase
MK616_RS09605	COG0318	PFAM AMP-dependent synthetase and ligase
MK616_RS09610	COG1960	acyl-CoA dehydrogenase activity
MK616_RS09615	COG1649	PFAM Uncharacterised BCR, COG1649
MK616_RS09625	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
MK616_RS09625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS09630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS09635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS09640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS09645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS09650	COG2027	D-alanyl-D-alanine carboxypeptidase
MK616_RS09655	COG2017	converts alpha-aldose to the beta-anomer
MK616_RS09660	COG0534	Mate efflux family protein
MK616_RS09675	COG0582	viral genome integration into host DNA
MK616_RS09680	COG0166	Belongs to the GPI family
MK616_RS09685	COG0405	Gamma-glutamyltransferase
MK616_RS09690	COG2814	Major facilitator Superfamily
MK616_RS09695	COG0640	Transcriptional regulator
MK616_RS09700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MK616_RS09710	COG0604	alcohol dehydrogenase
MK616_RS09720	COG0493	'glutamate synthase
MK616_RS09725	COG0069	glutamate synthase activity
MK616_RS09725	COG0067	glutamate synthase
MK616_RS09725	COG0070	glutamate synthase
MK616_RS09730	COG0583	DNA-binding transcription factor activity
MK616_RS09735	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MK616_RS09750	COG0300	oxidoreductase activity
MK616_RS09755	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MK616_RS09765	COG2814	Major facilitator Superfamily
MK616_RS09770	COG1070	Carbohydrate kinase
MK616_RS09775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MK616_RS09780	COG0243	molybdopterin cofactor binding
MK616_RS09810	COG5444	nuclease activity
MK616_RS09815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MK616_RS09820	COG0662	Cupin 2, conserved barrel domain protein
MK616_RS09820	COG2207	Transcriptional regulator
MK616_RS09825	COG1309	transcriptional regulator
MK616_RS09830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MK616_RS09840	COG0640	Transcriptional regulator
MK616_RS09845	COG0741	lytic transglycosylase activity
MK616_RS09850	COG2322	membrane
MK616_RS09865	COG1619	proteins homologs of microcin C7 resistance protein MccF
MK616_RS09875	COG3584	3D domain protein
MK616_RS09875	COG1388	LysM domain
MK616_RS09880	COG0514	ATP-dependent DNA helicase (RecQ)
MK616_RS09890	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MK616_RS09895	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MK616_RS09910	COG0071	Belongs to the small heat shock protein (HSP20) family
MK616_RS09940	COG1012	belongs to the aldehyde dehydrogenase family
MK616_RS09950	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MK616_RS09955	COG0733	neurotransmitter:sodium symporter activity
MK616_RS09960	COG0385	Bile acid
MK616_RS09965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MK616_RS09970	COG0508	dehydrogenase complex catalyzes the overall conversion of
MK616_RS09980	COG4548	von Willebrand factor, type A
MK616_RS09985	COG0714	Associated with various cellular activities
MK616_RS09990	COG2032	superoxide dismutase activity
MK616_RS09995	COG0791	NLP P60 protein
MK616_RS09995	COG1388	LysM domain
MK616_RS10000	COG1819	glycosyl
MK616_RS10005	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MK616_RS10010	COG0534	Mate efflux family protein
MK616_RS10015	COG1366	Belongs to the anti-sigma-factor antagonist family
MK616_RS10020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MK616_RS10025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MK616_RS10035	COG2962	Rard protein
MK616_RS10050	COG1942	4-Oxalocrotonate Tautomerase
MK616_RS10060	COG1733	regulation of RNA biosynthetic process
MK616_RS10065	COG0778	Nitroreductase
MK616_RS10070	COG0400	carboxylic ester hydrolase activity
MK616_RS10075	COG0346	lactoylglutathione lyase activity
MK616_RS10085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MK616_RS10095	COG2723	6-phospho-beta-galactosidase activity
MK616_RS10100	COG2188	Transcriptional regulator
MK616_RS10105	COG3409	Peptidoglycan-binding domain 1 protein
MK616_RS10105	COG0793	Belongs to the peptidase S41A family
MK616_RS10110	COG2226	methyltransferase
MK616_RS10120	COG1876	peptidase activity
MK616_RS10140	COG0671	phosphoesterase, PA-phosphatase related
MK616_RS10175	COG1509	lysine 2,3-aminomutase activity
MK616_RS10180	COG0456	acetyltransferase
MK616_RS10185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MK616_RS10190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MK616_RS10195	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MK616_RS10200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MK616_RS10205	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
MK616_RS10215	COG0456	acetyltransferase
MK616_RS10220	COG0463	Glycosyl transferase, family 2
MK616_RS10235	COG4641	Protein conserved in bacteria
MK616_RS10245	COG1086	Polysaccharide biosynthesis protein
MK616_RS10270	COG1388	LysM domain
MK616_RS10275	COG0457	Tetratricopeptide repeat
MK616_RS10310	COG5444	nuclease activity
MK616_RS10320	COG1525	nuclease
MK616_RS10355	COG1846	Transcriptional regulator
MK616_RS10360	COG4698	Protein conserved in bacteria
MK616_RS10365	COG2755	lipolytic protein G-D-S-L family
MK616_RS10370	COG1999	signal sequence binding
MK616_RS10380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MK616_RS10385	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MK616_RS10390	COG1272	protein, Hemolysin III
MK616_RS10395	COG0204	Acyl-transferase
MK616_RS10400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MK616_RS10415	COG2136	Putative SAM-dependent methyltransferase
MK616_RS10415	COG2521	methyltransferase
MK616_RS10430	COG1413	lyase activity
MK616_RS10435	COG1418	mRNA catabolic process
MK616_RS10440	COG0386	Belongs to the glutathione peroxidase family
MK616_RS10450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MK616_RS10460	COG1278	Cold shock
MK616_RS10480	COG0328	RNA-DNA hybrid ribonuclease activity
MK616_RS10485	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MK616_RS10490	COG0328	RNA-DNA hybrid ribonuclease activity
MK616_RS10500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MK616_RS10515	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MK616_RS10525	COG1755	Isoprenylcysteine carboxyl methyltransferase
MK616_RS10530	COG3424	synthase
MK616_RS10550	COG1335	isochorismatase
MK616_RS10590	COG4824	toxin secretion phage lysis holin
MK616_RS10610	COG5434	Belongs to the glycosyl hydrolase 28 family
MK616_RS10615	COG1705	Flagellar rod assembly protein muramidase FlgJ
MK616_RS10625	COG3953	SLT domain
MK616_RS10625	COG5280	Phage tail tape measure protein TP901
MK616_RS10725	COG1595	DNA-templated transcription, initiation
MK616_RS10755	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
MK616_RS10765	COG1484	DNA-dependent DNA replication
MK616_RS10770	COG3935	DnaD domain protein
MK616_RS10805	COG3645	SOS response
MK616_RS10805	COG3646	Phage regulatory protein
MK616_RS10820	COG3620	sequence-specific DNA binding
MK616_RS10825	COG0582	viral genome integration into host DNA
MK616_RS10830	COG2233	PERMEase
MK616_RS10840	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MK616_RS10845	COG1199	ATP-dependent helicase activity
MK616_RS10860	COG0116	Belongs to the methyltransferase superfamily
MK616_RS10890	COG3359	exonuclease
MK616_RS10895	COG1111	helicase
MK616_RS10895	COG1205	dead DEAH box helicase
MK616_RS10900	COG2190	(PTS) system
MK616_RS10905	COG0071	Belongs to the small heat shock protein (HSP20) family
MK616_RS10945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MK616_RS10945	COG4499	WXG100 protein secretion system (Wss), protein YukC
MK616_RS10955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MK616_RS10960	COG3935	DnaD domain protein
MK616_RS10970	COG0436	Aminotransferase
MK616_RS10975	COG5353	protein conserved in bacteria
MK616_RS10985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MK616_RS10985	COG1199	ATP-dependent helicase activity
MK616_RS11015	COG0438	transferase activity, transferring glycosyl groups
MK616_RS11020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MK616_RS11035	COG1694	Mazg nucleotide pyrophosphohydrolase
MK616_RS11040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MK616_RS11045	COG2140	Oxalate decarboxylase
MK616_RS11055	COG4347	Protein of unknown function (DUF1405)
MK616_RS11060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MK616_RS11060	COG2010	Cytochrome c
MK616_RS11065	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MK616_RS11070	COG0723	plastoquinol--plastocyanin reductase activity
MK616_RS11085	COG0457	Tetratricopeptide repeat
MK616_RS11095	COG0287	Prephenate dehydrogenase
MK616_RS11130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MK616_RS11135	COG4401	Chorismate mutase type I
MK616_RS11150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MK616_RS11155	COG0105	UTP biosynthetic process
MK616_RS11160	COG0142	geranyltranstransferase activity
MK616_RS11170	COG0142	geranyltranstransferase activity
MK616_RS11185	COG0776	regulation of translation
MK616_RS11190	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MK616_RS11230	COG0539	negative regulation of cytoplasmic translation
MK616_RS11245	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
MK616_RS11250	COG2959	enzyme of heme biosynthesis
MK616_RS11255	COG3773	Cell wall hydrolase
MK616_RS11255	COG3409	Peptidoglycan-binding domain 1 protein
MK616_RS11260	COG2339	peptidase activity
MK616_RS11265	COG0492	ferredoxin-NADP+ reductase activity
MK616_RS11270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MK616_RS11275	COG4862	establishment of competence for transformation
MK616_RS11280	COG1408	metallophosphoesterase
MK616_RS11290	COG1388	LysM domain
MK616_RS11295	COG1266	CAAX protease self-immunity
MK616_RS11300	COG0514	ATP-dependent DNA helicase (RecQ)
MK616_RS11305	COG4955	Helix-turn-helix domain
MK616_RS11310	COG1141	Ferredoxin
MK616_RS11315	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MK616_RS11320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MK616_RS11330	COG1595	DNA-templated transcription, initiation
MK616_RS11335	COG5002	protein histidine kinase activity
MK616_RS11340	COG0745	RESPONSE REGULATOR receiver
MK616_RS11345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MK616_RS11350	COG1333	cytochrome c biogenesis protein
MK616_RS11355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MK616_RS11360	COG1187	pseudouridine synthase activity
MK616_RS11365	COG0700	Nucleoside recognition
MK616_RS11370	COG2715	membrane protein required for spore maturation
MK616_RS11375	COG1686	Belongs to the peptidase S11 family
MK616_RS11400	COG1547	Domain of unknown function (DUF309)
MK616_RS11405	COG0456	acetyltransferase
MK616_RS11420	COG0307	riboflavin synthase, alpha
MK616_RS11425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MK616_RS11425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MK616_RS11435	COG0681	Belongs to the peptidase S26 family
MK616_RS11445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MK616_RS11450	COG4086	secreted protein
MK616_RS11455	COG0019	diaminopimelate decarboxylase activity
MK616_RS11460	COG0697	spore germination
MK616_RS11475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MK616_RS11495	COG1191	sigma factor activity
MK616_RS11505	COG1366	Belongs to the anti-sigma-factor antagonist family
MK616_RS11510	COG1686	Belongs to the peptidase S11 family
MK616_RS11515	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MK616_RS11520	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MK616_RS11525	COG4974	Belongs to the 'phage' integrase family
MK616_RS11535	COG0735	belongs to the Fur family
MK616_RS11540	COG1300	Membrane
MK616_RS11555	COG0281	malic enzyme
MK616_RS11560	COG1757	Na H antiporter
MK616_RS11565	COG1027	Aspartate ammonia-lyase
MK616_RS11570	COG0252	asparaginase activity
MK616_RS11575	COG1396	sequence-specific DNA binding
MK616_RS11580	COG1379	DNA repair
MK616_RS11585	COG0494	nUDIX hydrolase
MK616_RS11595	COG0667	Aldo Keto reductase
MK616_RS11605	COG1073	alpha beta
MK616_RS11615	COG4918	Iron-sulphur cluster biosynthesis
MK616_RS11620	COG0456	acetyltransferase
MK616_RS11620	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MK616_RS11625	COG2329	Antibiotic biosynthesis monooxygenase
MK616_RS11630	COG0456	acetyltransferase
MK616_RS11635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MK616_RS11650	COG0628	permease
MK616_RS11660	COG0346	lactoylglutathione lyase activity
MK616_RS11670	COG3048	D-serine ammonia-lyase activity
MK616_RS11675	COG0300	oxidoreductase activity
MK616_RS11680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MK616_RS11685	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MK616_RS11690	COG1024	Enoyl-CoA hydratase
MK616_RS11695	COG3425	synthase
MK616_RS11700	COG2124	cytochrome p450
MK616_RS11705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MK616_RS11705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MK616_RS11705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS11705	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS11705	COG3321	synthase
MK616_RS11710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS11710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MK616_RS11710	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS11710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MK616_RS11710	COG3321	synthase
MK616_RS11715	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS11715	COG0300	oxidoreductase activity
MK616_RS11715	COG0318	PFAM AMP-dependent synthetase and ligase
MK616_RS11715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS11715	COG3321	synthase
MK616_RS11720	COG0300	oxidoreductase activity
MK616_RS11720	COG0318	PFAM AMP-dependent synthetase and ligase
MK616_RS11720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS11720	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS11720	COG3321	synthase
MK616_RS11725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MK616_RS11725	COG3321	synthase
MK616_RS11725	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS11725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS11725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MK616_RS11730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS11730	COG0300	oxidoreductase activity
MK616_RS11730	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS11730	COG3321	synthase
MK616_RS11730	COG0318	PFAM AMP-dependent synthetase and ligase
MK616_RS11735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS11735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MK616_RS11735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MK616_RS11735	COG3321	synthase
MK616_RS11735	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS11740	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS11745	COG0318	PFAM AMP-dependent synthetase and ligase
MK616_RS11760	COG2070	2-Nitropropane dioxygenase
MK616_RS11760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MK616_RS11765	COG0250	Participates in transcription elongation, termination and antitermination
MK616_RS11790	COG0596	Alpha beta hydrolase
MK616_RS11805	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MK616_RS11810	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MK616_RS11825	COG0706	membrane insertase activity
MK616_RS11830	COG2195	Cleaves the N-terminal amino acid of tripeptides
MK616_RS11835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MK616_RS11840	COG0346	lactoylglutathione lyase activity
MK616_RS11850	COG1376	ErfK ybiS ycfS ynhG family protein
MK616_RS11855	COG4129	membrane
MK616_RS11860	COG1126	abc transporter atp-binding protein
MK616_RS11865	COG0765	amino acid transport
MK616_RS11870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MK616_RS11880	COG1597	lipid kinase activity
MK616_RS11885	COG0508	dehydrogenase complex catalyzes the overall conversion of
MK616_RS11890	COG0022	dehydrogenase e1 component
MK616_RS11895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MK616_RS11900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MK616_RS11905	COG3426	butyrate kinase activity
MK616_RS11910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MK616_RS11915	COG0280	phosphate acetyltransferase
MK616_RS11920	COG3290	protein histidine kinase activity
MK616_RS11920	COG3829	transcription factor binding
MK616_RS11930	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MK616_RS11935	COG2079	MmgE PrpD family protein
MK616_RS11940	COG0372	Belongs to the citrate synthase family
MK616_RS11945	COG1960	acyl-CoA dehydrogenase activity
MK616_RS11950	COG1250	3-hydroxyacyl-CoA dehydrogenase
MK616_RS11955	COG0183	Belongs to the thiolase family
MK616_RS11960	COG0584	glycerophosphoryl diester phosphodiesterase
MK616_RS11965	COG0860	N-Acetylmuramoyl-L-alanine amidase
MK616_RS11990	COG1902	pentaerythritol trinitrate reductase activity
MK616_RS12005	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MK616_RS12010	COG0745	RESPONSE REGULATOR receiver
MK616_RS12015	COG0750	zinc metalloprotease
MK616_RS12020	COG0497	DNA recombination
MK616_RS12030	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MK616_RS12040	COG0142	geranyltranstransferase activity
MK616_RS12050	COG1570	exodeoxyribonuclease VII activity
MK616_RS12065	COG1302	Protein conserved in bacteria
MK616_RS12070	COG0439	Biotin carboxylase
MK616_RS12075	COG0511	ligase activity, forming carbon-carbon bonds
MK616_RS12115	COG3854	ATPases associated with a variety of cellular activities
MK616_RS12130	COG0006	proline dipeptidase activity
MK616_RS12140	COG3872	metal-dependent enzyme
MK616_RS12150	COG1752	Esterase of the alpha-beta hydrolase superfamily
MK616_RS12165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MK616_RS12185	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MK616_RS12200	COG1396	sequence-specific DNA binding
MK616_RS12210	COG0681	Belongs to the peptidase S26 family
MK616_RS12235	COG4940	Competence protein ComGF
MK616_RS12245	COG4970	Tfp pilus assembly protein FimT
MK616_RS12250	COG4537	Required for transformation and DNA binding
MK616_RS12255	COG1459	type II secretion system
MK616_RS12260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MK616_RS12265	COG0598	Magnesium transport protein CorA
MK616_RS12270	COG1253	flavin adenine dinucleotide binding
MK616_RS12275	COG1366	Belongs to the anti-sigma-factor antagonist family
MK616_RS12285	COG1393	Belongs to the ArsC family
MK616_RS12295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MK616_RS12305	COG0011	TIGRFAM Protein of
MK616_RS12315	COG2866	Carboxypeptidase
MK616_RS12320	COG1940	carbohydrate kinase activity
MK616_RS12325	COG4483	Protein conserved in bacteria
MK616_RS12330	COG1757	Na H antiporter
MK616_RS12340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MK616_RS12355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MK616_RS12360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MK616_RS12365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MK616_RS12370	COG0581	inorganic phosphate transmembrane transporter activity
MK616_RS12375	COG0573	inorganic phosphate transmembrane transporter activity
MK616_RS12380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MK616_RS12385	COG0768	penicillin binding
MK616_RS12390	COG0477	Major facilitator Superfamily
MK616_RS12395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MK616_RS12400	COG2839	Protein conserved in bacteria
MK616_RS12405	COG5521	maltodextrose utilization protein MalA
MK616_RS12410	COG1388	LysM domain
MK616_RS12420	COG4709	membrane
MK616_RS12425	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
MK616_RS12430	COG0735	belongs to the Fur family
MK616_RS12435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MK616_RS12450	COG0513	Belongs to the DEAD box helicase family
MK616_RS12465	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MK616_RS12470	COG2384	SAM-dependent methyltransferase
MK616_RS12475	COG2010	Cytochrome c
MK616_RS12480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MK616_RS12485	COG0358	DNA primase activity
MK616_RS12500	COG0517	IMP dehydrogenase activity
MK616_RS12505	COG0751	glycine-tRNA ligase activity
MK616_RS12525	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MK616_RS12530	COG0295	cytidine deaminase activity
MK616_RS12535	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MK616_RS12545	COG1480	7TM receptor with intracellular HD hydrolase
MK616_RS12550	COG1702	phosphate starvation-inducible protein PhoH
MK616_RS12555	COG0561	phosphatase activity
MK616_RS12570	COG4864	UPF0365 protein
MK616_RS12575	COG1030	water channel activity
MK616_RS12580	COG1610	YqeY-like protein
MK616_RS12590	COG1283	sodium-dependent phosphate transmembrane transporter activity
MK616_RS12595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MK616_RS12600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MK616_RS12630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MK616_RS12645	COG0860	N-Acetylmuramoyl-L-alanine amidase
MK616_RS12675	COG0658	competence protein
MK616_RS12675	COG2333	competence protein COMEC
MK616_RS12680	COG2131	deaminase
MK616_RS12685	COG1555	photosystem II stabilization
MK616_RS12685	COG1596	polysaccharide export
MK616_RS12690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MK616_RS12695	COG2226	methyltransferase
MK616_RS12700	COG0799	negative regulation of ribosome biogenesis
MK616_RS12705	COG1713	HD superfamily hydrolase involved in NAD metabolism
MK616_RS12715	COG1534	Rna-binding protein
MK616_RS12720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MK616_RS12725	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MK616_RS12730	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MK616_RS12740	COG2755	lipolytic protein G-D-S-L family
MK616_RS12750	COG0398	Pfam SNARE associated Golgi protein
MK616_RS12785	COG5444	nuclease activity
MK616_RS12790	COG4282	regulation of fungal-type cell wall biogenesis
MK616_RS12805	COG2207	Transcriptional regulator
MK616_RS12805	COG3708	Transcriptional regulator
MK616_RS12810	COG0583	DNA-binding transcription factor activity
MK616_RS12825	COG0642	Histidine kinase
MK616_RS12825	COG5002	protein histidine kinase activity
MK616_RS12830	COG0745	RESPONSE REGULATOR receiver
MK616_RS12835	COG2311	Membrane
MK616_RS12845	COG0454	-acetyltransferase
MK616_RS12850	COG0563	adenylate kinase activity
MK616_RS12860	COG2814	Major facilitator Superfamily
MK616_RS12865	COG0456	acetyltransferase
MK616_RS12870	COG2318	DinB family
MK616_RS12880	COG0561	phosphatase activity
MK616_RS12895	COG1482	cell wall glycoprotein biosynthetic process
MK616_RS12900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MK616_RS12900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MK616_RS12900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MK616_RS12905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MK616_RS12905	COG3711	transcriptional antiterminator
MK616_RS12915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MK616_RS12920	COG0583	DNA-binding transcription factor activity
MK616_RS12925	COG2814	Major facilitator Superfamily
MK616_RS12930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MK616_RS12930	COG2124	cytochrome p450
MK616_RS12935	COG1309	transcriptional regulator
MK616_RS12940	COG2226	methyltransferase
MK616_RS12955	COG2116	formate transmembrane transporter activity
MK616_RS12960	COG5609	conserved protein (DUF2294)
MK616_RS12965	COG3383	formate dehydrogenase (NAD+) activity
MK616_RS12970	COG2427	Protein of unknown function (DUF1641)
MK616_RS12980	COG0626	cystathionine gamma-synthase activity
MK616_RS12985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MK616_RS13010	COG0768	penicillin binding
MK616_RS13025	COG0826	peptidase U32
MK616_RS13030	COG0826	peptidase U32
MK616_RS13035	COG4122	O-methyltransferase activity
MK616_RS13040	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MK616_RS13055	COG4472	Bacterial protein of unknown function (DUF965)
MK616_RS13065	COG0628	permease
MK616_RS13070	COG1126	abc transporter atp-binding protein
MK616_RS13075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MK616_RS13080	COG0765	amino acid transport
MK616_RS13085	COG0765	amino acid transport
MK616_RS13100	COG3881	PFAM PRC-barrel domain
MK616_RS13105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MK616_RS13110	COG0457	Tetratricopeptide repeat
MK616_RS13120	COG1104	cysteine desulfurase activity
MK616_RS13125	COG1959	2 iron, 2 sulfur cluster binding
MK616_RS13130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MK616_RS13135	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MK616_RS13160	COG3103	Sh3 type 3 domain protein
MK616_RS13160	COG4991	sh3 domain protein
MK616_RS13160	COG0860	N-Acetylmuramoyl-L-alanine amidase
MK616_RS13170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MK616_RS13180	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MK616_RS13180	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MK616_RS13185	COG5416	Lipopolysaccharide assembly protein A domain
MK616_RS13190	COG0490	domain, Protein
MK616_RS13195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MK616_RS13195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MK616_RS13205	COG2244	polysaccharide biosynthetic process
MK616_RS13210	COG2323	membrane
MK616_RS13220	COG1862	Preprotein translocase
MK616_RS13260	COG1388	LysM domain
MK616_RS13270	COG0157	Belongs to the NadC ModD family
MK616_RS13275	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MK616_RS13280	COG1104	cysteine desulfurase activity
MK616_RS13285	COG1827	regulation of RNA biosynthetic process
MK616_RS13290	COG0077	Prephenate dehydratase
MK616_RS13305	COG3290	protein histidine kinase activity
MK616_RS13310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MK616_RS13315	COG2868	ribosomal protein
MK616_RS13325	COG1994	Peptidase M50
MK616_RS13330	COG0739	heme binding
MK616_RS13335	COG2894	cell division
MK616_RS13345	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MK616_RS13355	COG1077	Cell shape determining protein MreB Mrl
MK616_RS13375	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MK616_RS13380	COG0285	dihydrofolate synthase activity
MK616_RS13385	COG0525	valine-tRNA ligase activity
MK616_RS13395	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MK616_RS13400	COG1388	LysM domain
MK616_RS13410	COG0113	porphobilinogen synthase activity
MK616_RS13415	COG1587	Uroporphyrinogen-III synthase
MK616_RS13425	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MK616_RS13445	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MK616_RS13450	COG0470	DNA polymerase III
MK616_RS13450	COG1067	ATP-dependent peptidase activity
MK616_RS13465	COG0457	Tetratricopeptide repeat
MK616_RS13465	COG1477	protein flavinylation
MK616_RS13480	COG0473	3-isopropylmalate dehydrogenase activity
MK616_RS13495	COG0440	acetolactate synthase activity
MK616_RS13500	COG0028	Belongs to the TPP enzyme family
MK616_RS13525	COG0622	Phosphoesterase
MK616_RS13530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MK616_RS13540	COG5401	PFAM Sporulation and spore germination
MK616_RS13550	COG1846	Transcriptional regulator
MK616_RS13555	COG2197	response regulator
MK616_RS13560	COG0824	Thioesterase
MK616_RS13565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MK616_RS13570	COG1053	succinate dehydrogenase
MK616_RS13575	COG2009	succinate dehydrogenase
MK616_RS13580	COG1719	4-vinyl reductase, 4VR
MK616_RS13585	COG0527	aspartate kinase activity
MK616_RS13595	COG3118	belongs to the thioredoxin family
MK616_RS13600	COG3534	alpha-L-arabinofuranosidase
MK616_RS13605	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MK616_RS13610	COG2086	electron transfer activity
MK616_RS13615	COG1024	Enoyl-CoA hydratase
MK616_RS13620	COG1309	transcriptional regulator
MK616_RS13625	COG0318	PFAM AMP-dependent synthetase and ligase
MK616_RS13635	COG3766	membrane
MK616_RS13645	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MK616_RS13645	COG1796	DNA polymerase
MK616_RS13650	COG1286	toxin biosynthetic process
MK616_RS13665	COG0072	phenylalanine-tRNA ligase activity
MK616_RS13665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MK616_RS13670	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MK616_RS13675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MK616_RS13685	COG3835	regulator
MK616_RS13690	COG0277	FAD linked oxidase domain protein
MK616_RS13695	COG0247	lactate metabolic process
MK616_RS13700	COG1966	Carbon starvation protein
MK616_RS13705	COG3534	alpha-L-arabinofuranosidase
MK616_RS13710	COG0395	ABC-type sugar transport system, permease component
MK616_RS13715	COG1175	transmembrane transport
MK616_RS13720	COG1653	transport
MK616_RS13730	COG0647	UMP catabolic process
MK616_RS13735	COG0235	Class ii aldolase
MK616_RS13740	COG1069	ribulokinase activity
MK616_RS13745	COG2160	L-arabinose isomerase activity
MK616_RS13750	COG3507	Belongs to the glycosyl hydrolase 43 family
MK616_RS13755	COG1363	Peptidase, m42
MK616_RS13765	COG3326	Membrane
MK616_RS13780	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MK616_RS13785	COG1346	cytolysis
MK616_RS13790	COG1380	Effector of murein hydrolase LrgA
MK616_RS13795	COG3279	Response regulator of the LytR AlgR family
MK616_RS13800	COG3275	phosphorelay sensor kinase activity
MK616_RS13805	COG1011	Hydrolase
MK616_RS13820	COG0398	Pfam SNARE associated Golgi protein
MK616_RS13825	COG1484	DNA-dependent DNA replication
MK616_RS13830	COG3611	Membrane attachment protein
MK616_RS13845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MK616_RS13850	COG1733	regulation of RNA biosynthetic process
MK616_RS13855	COG2814	Major facilitator Superfamily
MK616_RS13860	COG0656	L-ascorbic acid biosynthetic process
MK616_RS13865	COG0237	dephospho-CoA kinase activity
MK616_RS13870	COG1971	Probably functions as a manganese efflux pump
MK616_RS13875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MK616_RS13880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MK616_RS13880	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MK616_RS13885	COG5002	protein histidine kinase activity
MK616_RS13890	COG0745	RESPONSE REGULATOR receiver
MK616_RS13900	COG0538	isocitrate dehydrogenase activity
MK616_RS13905	COG0372	Belongs to the citrate synthase family
MK616_RS13915	COG0457	Tetratricopeptide repeat
MK616_RS13945	COG0628	permease
MK616_RS13950	COG3030	protein affecting phage T7 exclusion by the F plasmid
MK616_RS13955	COG0469	pyruvate kinase activity
MK616_RS13975	COG0281	malic enzyme
MK616_RS13980	COG0587	DNA-directed DNA polymerase activity
MK616_RS14000	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MK616_RS14010	COG4109	DRTGG domain
MK616_RS14020	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS14035	COG0521	Mo-molybdopterin cofactor biosynthetic process
MK616_RS14045	COG0827	DNA restriction-modification system
MK616_RS14050	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MK616_RS14055	COG3874	Sporulation protein YtfJ
MK616_RS14065	COG1714	RDD family
MK616_RS14070	COG0616	signal peptide processing
MK616_RS14075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MK616_RS14080	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MK616_RS14085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MK616_RS14100	COG1104	cysteine desulfurase activity
MK616_RS14105	COG1114	Component of the transport system for branched-chain amino acids
MK616_RS14115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MK616_RS14120	COG1309	transcriptional regulator
MK616_RS14125	COG1956	GAF domain-containing protein
MK616_RS14130	COG2203	Gaf domain
MK616_RS14130	COG2199	diguanylate cyclase activity
MK616_RS14140	COG1012	belongs to the aldehyde dehydrogenase family
MK616_RS14145	COG4282	regulation of fungal-type cell wall biogenesis
MK616_RS14190	COG1017	nitric oxide dioxygenase activity
MK616_RS14190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MK616_RS14200	COG0693	protein deglycase activity
MK616_RS14215	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MK616_RS14220	COG1378	Sugar-specific transcriptional regulator TrmB
MK616_RS14240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MK616_RS14245	COG0454	-acetyltransferase
MK616_RS14250	COG0517	IMP dehydrogenase activity
MK616_RS14255	COG0123	including yeast histone deacetylase and acetoin utilization protein
MK616_RS14260	COG1360	Flagellar Motor Protein
MK616_RS14265	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MK616_RS14270	COG1609	Transcriptional regulator
MK616_RS14275	COG1605	Chorismate mutase
MK616_RS14275	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MK616_RS14280	COG3118	belongs to the thioredoxin family
MK616_RS14285	COG4980	gas vesicle protein
MK616_RS14290	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MK616_RS14300	COG1674	ftsk spoiiie
MK616_RS14305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MK616_RS14315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MK616_RS14325	COG1363	Peptidase, m42
MK616_RS14330	COG5584	Small secreted protein
MK616_RS14335	COG0281	malic enzyme
MK616_RS14340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MK616_RS14355	COG0510	thiamine kinase activity
MK616_RS14360	COG1597	lipid kinase activity
MK616_RS14370	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MK616_RS14375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MK616_RS14380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MK616_RS14385	COG2252	PERMEase
MK616_RS14390	COG4473	ABC transporter
MK616_RS14395	COG1131	(ABC) transporter
MK616_RS14400	COG1349	DNA-binding transcription factor activity
MK616_RS14405	COG1187	pseudouridine synthase activity
MK616_RS14410	COG2244	polysaccharide biosynthetic process
MK616_RS14415	COG2081	HI0933 family
MK616_RS14420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MK616_RS14430	COG1609	Transcriptional regulator
MK616_RS14435	COG1653	transport
MK616_RS14440	COG1175	transmembrane transport
MK616_RS14445	COG0395	ABC-type sugar transport system, permease component
MK616_RS14450	COG1486	melibiose metabolic process
MK616_RS14460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MK616_RS14475	COG1366	Belongs to the anti-sigma-factor antagonist family
MK616_RS14475	COG2202	Pas domain
MK616_RS14480	COG2814	Major facilitator Superfamily
MK616_RS14485	COG5522	Integral membrane protein (intg_mem_TP0381)
MK616_RS14490	COG0577	efflux transmembrane transporter activity
MK616_RS14495	COG1136	(ABC) transporter
MK616_RS14500	COG2205	protein histidine kinase activity
MK616_RS14505	COG0745	RESPONSE REGULATOR receiver
MK616_RS14510	COG0577	efflux transmembrane transporter activity
MK616_RS14515	COG1136	(ABC) transporter
MK616_RS14535	COG1131	(ABC) transporter
MK616_RS14540	COG1725	Transcriptional regulator
MK616_RS14555	COG0640	Transcriptional regulator
MK616_RS14560	COG0477	Major facilitator Superfamily
MK616_RS14565	COG1242	4 iron, 4 sulfur cluster binding
MK616_RS14570	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MK616_RS14580	COG0584	glycerophosphoryl diester phosphodiesterase
MK616_RS14590	COG2267	carboxylic ester hydrolase activity
MK616_RS14595	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MK616_RS14600	COG1113	amino acid transport
MK616_RS14605	COG0367	asparagine synthase
MK616_RS14625	COG1506	peptidase
MK616_RS14630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MK616_RS14635	COG1116	anion transmembrane transporter activity
MK616_RS14640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MK616_RS14645	COG0494	nUDIX hydrolase
MK616_RS14650	COG4824	toxin secretion phage lysis holin
MK616_RS14655	COG0783	Belongs to the Dps family
MK616_RS14680	COG0288	reversible hydration of carbon dioxide
MK616_RS14690	COG1271	oxidase subunit
MK616_RS14695	COG1294	oxidase, subunit
MK616_RS14705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MK616_RS14710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MK616_RS14710	COG1321	iron dependent repressor
MK616_RS14715	COG1121	(ABC) transporter
MK616_RS14720	COG0803	Belongs to the bacterial solute-binding protein 9 family
MK616_RS14725	COG4948	Mandelate Racemase Muconate Lactonizing
MK616_RS14735	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MK616_RS14740	COG0596	Alpha beta hydrolase
MK616_RS14750	COG1169	isochorismate synthase
MK616_RS14755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MK616_RS14760	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MK616_RS14885	COG3859	Proton-coupled thiamine transporter YuaJ
MK616_RS14890	COG2268	Band 7 protein
MK616_RS14895	COG1585	Membrane protein implicated in regulation of membrane protease activity
MK616_RS14900	COG2318	DinB family
MK616_RS14910	COG1454	alcohol dehydrogenase
MK616_RS14915	COG1012	belongs to the aldehyde dehydrogenase family
MK616_RS14920	COG1510	regulation of RNA biosynthetic process
MK616_RS14930	COG0569	domain protein
MK616_RS14935	COG1705	Flagellar rod assembly protein muramidase FlgJ
MK616_RS14940	COG1017	nitric oxide dioxygenase activity
MK616_RS14940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MK616_RS14965	COG0628	permease
MK616_RS14970	COG0673	inositol 2-dehydrogenase activity
MK616_RS14975	COG0693	protein deglycase activity
MK616_RS14980	COG0840	transmembrane signaling receptor activity
MK616_RS14985	COG0840	transmembrane signaling receptor activity
MK616_RS14990	COG0840	transmembrane signaling receptor activity
MK616_RS14995	COG0840	transmembrane signaling receptor activity
MK616_RS15010	COG2070	2-Nitropropane dioxygenase
MK616_RS15020	COG0366	Alpha amylase catalytic
MK616_RS15025	COG1253	flavin adenine dinucleotide binding
MK616_RS15030	COG2738	Putative neutral zinc metallopeptidase
MK616_RS15045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MK616_RS15070	COG1335	isochorismatase
MK616_RS15075	COG1979	alcohol dehydrogenase
MK616_RS15080	COG1979	alcohol dehydrogenase
MK616_RS15085	COG2155	Conserved Protein
MK616_RS15090	COG1098	S1 RNA binding domain
MK616_RS15095	COG0436	Aminotransferase
MK616_RS15100	COG1522	sequence-specific DNA binding
MK616_RS15105	COG2267	carboxylic ester hydrolase activity
MK616_RS15115	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MK616_RS15120	COG2205	protein histidine kinase activity
MK616_RS15130	COG5018	Exonuclease
MK616_RS15135	COG2814	Major facilitator Superfamily
MK616_RS15140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MK616_RS15145	COG3011	Protein conserved in bacteria
MK616_RS15155	COG3290	protein histidine kinase activity
MK616_RS15160	COG4565	transcriptional regulatory protein
MK616_RS15165	COG1744	ABC transporter substrate-binding protein PnrA-like
MK616_RS15170	COG3845	ABC transporter
MK616_RS15175	COG4603	Belongs to the binding-protein-dependent transport system permease family
MK616_RS15180	COG1079	Belongs to the binding-protein-dependent transport system permease family
MK616_RS15190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MK616_RS15190	COG2111	Na H antiporter
MK616_RS15195	COG2111	Na H antiporter
MK616_RS15200	COG1006	Multisubunit Na H antiporter MnhC subunit
MK616_RS15205	COG0651	ATP synthesis coupled electron transport
MK616_RS15210	COG1863	multisubunit Na H antiporter MnhE subunit
MK616_RS15215	COG2212	antiporter activity
MK616_RS15220	COG1320	monovalent cation:proton antiporter activity
MK616_RS15225	COG2050	protein possibly involved in aromatic compounds catabolism
MK616_RS15230	COG2197	response regulator
MK616_RS15235	COG4585	Histidine kinase
MK616_RS15245	COG0142	geranyltranstransferase activity
MK616_RS15260	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MK616_RS15265	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MK616_RS15270	COG1335	isochorismatase
MK616_RS15275	COG5506	Protein of unknown function (DUF1694)
MK616_RS15290	COG0628	permease
MK616_RS15300	COG1418	mRNA catabolic process
MK616_RS15305	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS15315	COG1511	domain protein
MK616_RS15320	COG0433	COG0433 Predicted ATPase
MK616_RS15320	COG1674	ftsk spoiiie
MK616_RS15325	COG4499	WXG100 protein secretion system (Wss), protein YukC
MK616_RS15330	COG5417	Belongs to the EsaB family
MK616_RS15335	COG4842	Belongs to the WXG100 family
MK616_RS15340	COG2508	Transcriptional regulator
MK616_RS15340	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MK616_RS15345	COG0686	Belongs to the AlaDH PNT family
MK616_RS15350	COG5634	Uncharacterized conserved protein (DUF2278)
MK616_RS15355	COG3251	PFAM MbtH domain protein
MK616_RS15360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MK616_RS15365	COG1535	isochorismatase
MK616_RS15365	COG3433	isochorismatase activity
MK616_RS15370	COG1021	2,3-dihydroxybenzoate-AMP ligase
MK616_RS15375	COG1169	isochorismate synthase
MK616_RS15380	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS15385	COG2819	hydrolase of the alpha beta superfamily
MK616_RS15390	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MK616_RS15395	COG1268	BioY protein
MK616_RS15400	COG2056	Na+-H+ antiporter family
MK616_RS15410	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
MK616_RS15415	COG3584	3D domain protein
MK616_RS15430	COG1252	NADH dehydrogenase
MK616_RS15460	COG1131	(ABC) transporter
MK616_RS15480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MK616_RS15485	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
MK616_RS15490	COG0316	Belongs to the HesB IscA family
MK616_RS15500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MK616_RS15510	COG1252	NADH dehydrogenase
MK616_RS15515	COG4837	Protein of unknown function (DUF1462)
MK616_RS15520	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MK616_RS15525	COG0823	Involved in the tonB-independent uptake of proteins
MK616_RS15525	COG1506	peptidase
MK616_RS15525	COG4946	Tricorn protease homolog
MK616_RS15535	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MK616_RS15540	COG0460	homoserine dehydrogenase
MK616_RS15545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MK616_RS15550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MK616_RS15555	COG0647	UMP catabolic process
MK616_RS15560	COG2445	Protein of unknown function DUF86
MK616_RS15565	COG4470	Protein conserved in bacteria
MK616_RS15575	COG0739	heme binding
MK616_RS15585	COG0737	Belongs to the 5'-nucleotidase family
MK616_RS15590	COG0730	response to heat
MK616_RS15595	COG1801	Protein of unknown function DUF72
MK616_RS15610	COG2508	Transcriptional regulator
MK616_RS15615	COG0457	Tetratricopeptide repeat
MK616_RS15630	COG2814	Major facilitator Superfamily
MK616_RS15635	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MK616_RS15640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MK616_RS15645	COG2356	endonuclease I
MK616_RS15650	COG3842	ATPase activity
MK616_RS15655	COG2188	Transcriptional regulator
MK616_RS15660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MK616_RS15665	COG0395	ABC-type sugar transport system, permease component
MK616_RS15670	COG1175	transmembrane transport
MK616_RS15675	COG1653	transport
MK616_RS15680	COG2222	sugar isomerase
MK616_RS15685	COG0789	Transcriptional regulator
MK616_RS15710	COG0322	excinuclease ABC activity
MK616_RS15715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MK616_RS15735	COG3409	Peptidoglycan-binding domain 1 protein
MK616_RS15740	COG0719	Fe-S assembly protein
MK616_RS15745	COG0822	iron-sulfur transferase activity
MK616_RS15750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MK616_RS15755	COG0719	Fe-S assembly protein
MK616_RS15760	COG0396	ATPase activity
MK616_RS15770	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MK616_RS15775	COG1464	Belongs to the NlpA lipoprotein family
MK616_RS15780	COG2011	ABC-type metal ion transport system permease component
MK616_RS15785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MK616_RS15795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MK616_RS15800	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MK616_RS15815	COG1393	Belongs to the ArsC family
MK616_RS15820	COG1960	acyl-CoA dehydrogenase activity
MK616_RS15825	COG0183	Belongs to the thiolase family
MK616_RS15830	COG1024	Enoyl-CoA hydratase
MK616_RS15830	COG1250	3-hydroxyacyl-CoA dehydrogenase
MK616_RS15850	COG5577	PFAM Coat F domain
MK616_RS15855	COG1846	Transcriptional regulator
MK616_RS15860	COG0477	Major facilitator Superfamily
MK616_RS15865	COG0583	DNA-binding transcription factor activity
MK616_RS15885	COG1120	ATPase activity
MK616_RS15900	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS15905	COG0783	Belongs to the Dps family
MK616_RS15910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MK616_RS15915	COG0745	RESPONSE REGULATOR receiver
MK616_RS15920	COG2770	Histidine kinase
MK616_RS15920	COG2205	protein histidine kinase activity
MK616_RS15930	COG1309	transcriptional regulator
MK616_RS15935	COG0114	fumarate hydratase activity
MK616_RS15945	COG0697	spore germination
MK616_RS15950	COG0814	amino acid
MK616_RS15960	COG2197	response regulator
MK616_RS15965	COG4585	Histidine kinase
MK616_RS15970	COG4758	membrane
MK616_RS15975	COG3595	metallopeptidase activity
MK616_RS15980	COG1842	Phage shock protein A
MK616_RS15985	COG4758	membrane
MK616_RS15990	COG2814	Major facilitator Superfamily
MK616_RS15995	COG2096	Adenosyltransferase
MK616_RS16000	COG1120	ATPase activity
MK616_RS16005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MK616_RS16010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MK616_RS16015	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS16020	COG3386	PFAM SMP-30 Gluconolaconase
MK616_RS16025	COG2205	protein histidine kinase activity
MK616_RS16030	COG0745	RESPONSE REGULATOR receiver
MK616_RS16040	COG1191	sigma factor activity
MK616_RS16050	COG2140	Oxalate decarboxylase
MK616_RS16060	COG1120	ATPase activity
MK616_RS16065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MK616_RS16070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MK616_RS16075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MK616_RS16080	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MK616_RS16085	COG0531	amino acid
MK616_RS16095	COG1988	membrane-bound metal-dependent
MK616_RS16100	COG1368	sulfuric ester hydrolase activity
MK616_RS16105	COG1910	domain protein
MK616_RS16110	COG0725	ABC transporter, periplasmic molybdate-binding protein
MK616_RS16115	COG4149	molybdate abc transporter
MK616_RS16120	COG2197	response regulator
MK616_RS16125	COG3850	Histidine kinase
MK616_RS16130	COG1131	(ABC) transporter
MK616_RS16140	COG0842	Transport permease protein
MK616_RS16145	COG0656	L-ascorbic acid biosynthetic process
MK616_RS16165	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MK616_RS16170	COG3973	AAA domain
MK616_RS16185	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MK616_RS16190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MK616_RS16195	COG2217	Heavy metal translocating P-type atpase
MK616_RS16200	COG2217	Heavy metal translocating P-type atpase
MK616_RS16205	COG2608	mercury ion transmembrane transporter activity
MK616_RS16210	COG1937	Protein conserved in bacteria
MK616_RS16215	COG0673	inositol 2-dehydrogenase activity
MK616_RS16225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MK616_RS16230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MK616_RS16235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MK616_RS16240	COG1126	abc transporter atp-binding protein
MK616_RS16245	COG0765	amino acid transport
MK616_RS16250	COG0765	amino acid transport
MK616_RS16255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MK616_RS16260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MK616_RS16265	COG0454	-acetyltransferase
MK616_RS16270	COG0583	DNA-binding transcription factor activity
MK616_RS16275	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS16280	COG2732	(Barnase) inhibitor
MK616_RS16285	COG2732	(Barnase) inhibitor
MK616_RS16300	COG0557	exoribonuclease II activity
MK616_RS16305	COG1647	Serine aminopeptidase, S33
MK616_RS16310	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MK616_RS16315	COG1476	TRANSCRIPTIONal
MK616_RS16320	COG1396	sequence-specific DNA binding
MK616_RS16325	COG1396	sequence-specific DNA binding
MK616_RS16330	COG1733	regulation of RNA biosynthetic process
MK616_RS16355	COG1131	(ABC) transporter
MK616_RS16360	COG1174	glycine betaine transport
MK616_RS16365	COG1732	Glycine betaine
MK616_RS16370	COG1174	glycine betaine transport
MK616_RS16375	COG0517	IMP dehydrogenase activity
MK616_RS16375	COG1125	glycine betaine transport
MK616_RS16380	COG1510	regulation of RNA biosynthetic process
MK616_RS16385	COG1174	glycine betaine transport
MK616_RS16390	COG1732	Glycine betaine
MK616_RS16395	COG1174	glycine betaine transport
MK616_RS16400	COG0517	IMP dehydrogenase activity
MK616_RS16400	COG1125	glycine betaine transport
MK616_RS16405	COG1510	regulation of RNA biosynthetic process
MK616_RS16410	COG2095	MarC family integral membrane protein
MK616_RS16415	COG3064	Membrane
MK616_RS16420	COG4640	response to antibiotic
MK616_RS16425	COG0456	acetyltransferase
MK616_RS16445	COG0126	phosphoglycerate kinase activity
MK616_RS16450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MK616_RS16455	COG2390	Transcriptional regulator
MK616_RS16460	COG2814	Major facilitator Superfamily
MK616_RS16465	COG1609	Transcriptional regulator
MK616_RS16470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MK616_RS16475	COG0583	DNA-binding transcription factor activity
MK616_RS16480	COG0697	spore germination
MK616_RS16485	COG1113	amino acid transport
MK616_RS16495	COG1737	Transcriptional regulator
MK616_RS16500	COG1070	Carbohydrate kinase
MK616_RS16530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MK616_RS16535	COG2186	Transcriptional regulator
MK616_RS16540	COG1620	l-lactate permease
MK616_RS16545	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MK616_RS16555	COG5039	Polysaccharide pyruvyl transferase
MK616_RS16560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MK616_RS16565	COG0110	maltose O-acetyltransferase activity
MK616_RS16570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MK616_RS16575	COG2244	polysaccharide biosynthetic process
MK616_RS16580	COG1216	Glycosyl transferase, family 2
MK616_RS16585	COG5039	Polysaccharide pyruvyl transferase
MK616_RS16590	COG1216	Glycosyl transferase, family 2
MK616_RS16600	COG0438	transferase activity, transferring glycosyl groups
MK616_RS16605	COG1215	transferase activity, transferring glycosyl groups
MK616_RS16610	COG0438	transferase activity, transferring glycosyl groups
MK616_RS16615	COG1086	Polysaccharide biosynthesis protein
MK616_RS16620	COG0489	protein tyrosine kinase activity
MK616_RS16625	COG3944	biosynthesis protein
MK616_RS16630	COG1396	sequence-specific DNA binding
MK616_RS16635	COG2272	Belongs to the type-B carboxylesterase lipase family
MK616_RS16645	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MK616_RS16650	COG2364	Membrane
MK616_RS16655	COG0456	acetyltransferase
MK616_RS16660	COG3479	Phenolic acid decarboxylase
MK616_RS16720	COG2223	nitrite transmembrane transporter activity
MK616_RS16725	COG1609	Transcriptional regulator
MK616_RS16735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MK616_RS16740	COG0366	Alpha amylase catalytic
MK616_RS16745	COG1554	hydrolase, family 65, central catalytic
MK616_RS16750	COG5521	maltodextrose utilization protein MalA
MK616_RS16755	COG3833	ABC-type maltose transport systems, permease component
MK616_RS16760	COG1175	transmembrane transport
MK616_RS16765	COG2182	Extracellular solute-binding protein
MK616_RS16770	COG0366	Alpha amylase catalytic
MK616_RS16775	COG1609	Transcriptional regulator
MK616_RS16780	COG1611	Belongs to the LOG family
MK616_RS16785	COG1694	Mazg nucleotide pyrophosphohydrolase
MK616_RS16790	COG0659	secondary active sulfate transmembrane transporter activity
MK616_RS16795	COG0288	reversible hydration of carbon dioxide
MK616_RS16800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MK616_RS16805	COG4290	ribonuclease
MK616_RS16810	COG2162	N-hydroxyarylamine O-acetyltransferase activity
MK616_RS16815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MK616_RS16825	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MK616_RS16835	COG1051	belongs to the nudix hydrolase family
MK616_RS16840	COG0492	ferredoxin-NADP+ reductase activity
MK616_RS16845	COG0791	NLP P60 protein
MK616_RS16845	COG3883	PFAM NLP P60 protein
MK616_RS16850	COG0457	Tetratricopeptide repeat
MK616_RS16855	COG5002	protein histidine kinase activity
MK616_RS16860	COG0745	RESPONSE REGULATOR receiver
MK616_RS16870	COG1132	(ABC) transporter
MK616_RS16875	COG0140	phosphoribosyl-ATP diphosphatase activity
MK616_RS16875	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MK616_RS16900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MK616_RS16915	COG4990	cell redox homeostasis
MK616_RS16920	COG0110	maltose O-acetyltransferase activity
MK616_RS16940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MK616_RS16950	COG2188	Transcriptional regulator
MK616_RS16955	COG1309	transcriptional regulator
MK616_RS16960	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MK616_RS16965	COG1950	PFAM Membrane protein of
MK616_RS16970	COG1983	PspC domain protein
MK616_RS16975	COG3595	metallopeptidase activity
MK616_RS16990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MK616_RS17000	COG4897	Protein conserved in bacteria
MK616_RS17005	COG3848	Pyruvate phosphate dikinase
MK616_RS17005	COG0574	Belongs to the PEP-utilizing enzyme family
MK616_RS17010	COG1309	transcriptional regulator
MK616_RS17015	COG2814	Major facilitator Superfamily
MK616_RS17050	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS17065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MK616_RS17075	COG0793	Belongs to the peptidase S41A family
MK616_RS17075	COG3409	Peptidoglycan-binding domain 1 protein
MK616_RS17080	COG3420	alginic acid biosynthetic process
MK616_RS17085	COG2177	Part of the ABC transporter FtsEX involved in
MK616_RS17090	COG2884	Cell division ATP-binding protein ftsE
MK616_RS17095	COG2010	Cytochrome c
MK616_RS17100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MK616_RS17115	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MK616_RS17130	COG1516	flagellar protein fliS
MK616_RS17135	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MK616_RS17140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MK616_RS17160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MK616_RS17165	COG1256	bacterial-type flagellum assembly
MK616_RS17165	COG4786	Flagellar basal body rod
MK616_RS17170	COG3418	PFAM FlgN family protein
MK616_RS17175	COG2747	anti-sigma28 factor FlgM
MK616_RS17185	COG1040	competence protein
MK616_RS17195	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MK616_RS17200	COG1307	EDD domain protein, DegV family
MK616_RS17205	COG2197	response regulator
MK616_RS17210	COG4585	Histidine kinase
MK616_RS17215	COG1739	Uncharacterized protein family UPF0029
MK616_RS17220	COG1316	TRANSCRIPTIONal
MK616_RS17225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MK616_RS17230	COG0438	transferase activity, transferring glycosyl groups
MK616_RS17235	COG1215	transferase activity, transferring glycosyl groups
MK616_RS17240	COG3206	protein involved in exopolysaccharide biosynthesis
MK616_RS17245	COG3307	-O-antigen
MK616_RS17250	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MK616_RS17255	COG0438	transferase activity, transferring glycosyl groups
MK616_RS17255	COG0297	glycogen (starch) synthase activity
MK616_RS17260	COG2244	polysaccharide biosynthetic process
MK616_RS17270	COG2247	cell wall binding repeat
MK616_RS17270	COG0860	N-Acetylmuramoyl-L-alanine amidase
MK616_RS17275	COG2385	sporulation resulting in formation of a cellular spore
MK616_RS17275	COG2247	cell wall binding repeat
MK616_RS17285	COG1316	TRANSCRIPTIONal
MK616_RS17290	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MK616_RS17295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MK616_RS17300	COG1134	teichoic acid transport
MK616_RS17305	COG1682	transport, permease protein
MK616_RS17310	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MK616_RS17320	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MK616_RS17325	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
MK616_RS17330	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MK616_RS17335	COG4193	domain, Protein
MK616_RS17340	COG1482	cell wall glycoprotein biosynthetic process
MK616_RS17345	COG0697	spore germination
MK616_RS17350	COG0814	amino acid
MK616_RS17360	COG1215	transferase activity, transferring glycosyl groups
MK616_RS17365	COG2814	Major facilitator Superfamily
MK616_RS17370	COG1316	TRANSCRIPTIONal
MK616_RS17375	COG0561	phosphatase activity
MK616_RS17380	COG2433	Pfam Transposase IS66
MK616_RS17385	COG0791	NLP P60 protein
MK616_RS17395	COG2843	Capsule synthesis protein
MK616_RS17405	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MK616_RS17410	COG0697	spore germination
MK616_RS17415	COG0814	amino acid
MK616_RS17425	COG1609	Transcriptional regulator
MK616_RS17430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MK616_RS17440	COG1129	ABC transporter
MK616_RS17445	COG1172	Belongs to the binding-protein-dependent transport system permease family
MK616_RS17450	COG1879	ABC-type sugar transport system periplasmic component
MK616_RS17455	COG3103	Sh3 type 3 domain protein
MK616_RS17460	COG2249	NAD(P)H dehydrogenase (quinone) activity
MK616_RS17465	COG3527	Alpha-acetolactate decarboxylase
MK616_RS17470	COG0028	Belongs to the TPP enzyme family
MK616_RS17475	COG0583	DNA-binding transcription factor activity
MK616_RS17480	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MK616_RS17495	COG5337	Spore coat protein CotH
MK616_RS17505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MK616_RS17515	COG0405	Gamma-glutamyltransferase
MK616_RS17520	COG1522	sequence-specific DNA binding
MK616_RS17525	COG2059	Chromate
MK616_RS17530	COG2059	Chromate
MK616_RS17540	COG0655	NAD(P)H dehydrogenase (quinone) activity
MK616_RS17545	COG0583	DNA-binding transcription factor activity
MK616_RS17565	COG5444	nuclease activity
MK616_RS17580	COG3878	Protein conserved in bacteria
MK616_RS17585	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MK616_RS17590	COG4464	protein tyrosine phosphatase activity
MK616_RS17595	COG0489	protein tyrosine kinase activity
MK616_RS17600	COG3944	biosynthesis protein
MK616_RS17610	COG4715	Zinc finger, swim domain protein
MK616_RS17615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MK616_RS17620	COG0561	phosphatase activity
MK616_RS17625	COG1349	DNA-binding transcription factor activity
MK616_RS17630	COG0629	single-stranded DNA binding
MK616_RS17655	COG0457	Tetratricopeptide repeat
MK616_RS17660	COG4786	Flagellar basal body rod
MK616_RS17665	COG4786	Flagellar basal body rod
MK616_RS17670	COG1077	Cell shape determining protein MreB Mrl
MK616_RS17675	COG1609	Transcriptional regulator
MK616_RS17680	COG1846	Transcriptional regulator
MK616_RS17685	COG2814	Major facilitator Superfamily
MK616_RS17690	COG1953	Uracil, thiamine, allantoin
MK616_RS17695	COG0477	Major facilitator Superfamily
MK616_RS17700	COG1335	isochorismatase
MK616_RS17705	COG0004	ammonium transporteR
MK616_RS17710	COG0347	Belongs to the P(II) protein family
MK616_RS17715	COG0772	Belongs to the SEDS family
MK616_RS17720	COG0671	phosphoesterase, PA-phosphatase related
MK616_RS17730	COG0739	heme binding
MK616_RS17735	COG1247	-acetyltransferase
MK616_RS17750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MK616_RS17760	COG0726	polysaccharide deacetylase
MK616_RS17765	COG1959	2 iron, 2 sulfur cluster binding
MK616_RS17780	COG0831	urea catabolic process
MK616_RS17785	COG3237	CsbD-like
MK616_RS17790	COG1994	Peptidase M50
MK616_RS17795	COG0457	Tetratricopeptide repeat
MK616_RS17805	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MK616_RS17815	COG2304	oxidoreductase activity
MK616_RS17820	COG2304	oxidoreductase activity
MK616_RS17825	COG2385	sporulation resulting in formation of a cellular spore
MK616_RS17830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MK616_RS17840	COG4836	Membrane
MK616_RS17910	COG0698	ribose 5-phosphate isomerase
MK616_RS17915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MK616_RS17925	COG0009	L-threonylcarbamoyladenylate synthase
MK616_RS17930	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MK616_RS17950	COG2890	protein-(glutamine-N5) methyltransferase activity
MK616_RS17955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MK616_RS17960	COG0346	lactoylglutathione lyase activity
MK616_RS17965	COG0789	Transcriptional regulator
MK616_RS17970	COG0679	Auxin Efflux Carrier
MK616_RS17975	COG0281	malic enzyme
MK616_RS17990	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MK616_RS18000	COG1494	fructose-1,6-bisphosphatase
MK616_RS18005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MK616_RS18015	COG0191	fructose-bisphosphate aldolase activity
MK616_RS18020	COG2204	response regulator
MK616_RS18025	COG4821	SIS domain
MK616_RS18040	COG2181	nitrate reductase activity
MK616_RS18040	COG0247	lactate metabolic process
MK616_RS18045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MK616_RS18060	COG1132	(ABC) transporter
MK616_RS18065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MK616_RS18075	COG2181	nitrate reductase activity
MK616_RS18080	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
MK616_RS18085	COG1140	nitrate reductase beta subunit
MK616_RS18090	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MK616_RS18095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MK616_RS18105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MK616_RS18110	COG2223	nitrite transmembrane transporter activity
MK616_RS18120	COG4506	Protein conserved in bacteria
MK616_RS18125	COG0457	Tetratricopeptide repeat
MK616_RS18165	COG0010	Belongs to the arginase family
MK616_RS18170	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MK616_RS18175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MK616_RS18190	COG1994	Peptidase M50
MK616_RS18195	COG1942	4-Oxalocrotonate Tautomerase
MK616_RS18200	COG1846	Transcriptional regulator
MK616_RS18205	COG0531	amino acid
MK616_RS18210	COG3465	dGTPase activity
MK616_RS18215	COG1078	dGTPase activity
MK616_RS18230	COG1695	Transcriptional regulator
MK616_RS18240	COG1131	(ABC) transporter
MK616_RS18245	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MK616_RS18275	COG0583	DNA-binding transcription factor activity
MK616_RS18280	COG2855	membrane
MK616_RS18285	COG0280	phosphate acetyltransferase
MK616_RS18295	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS18300	COG0436	Aminotransferase
MK616_RS18330	COG2814	Major facilitator Superfamily
MK616_RS18335	COG2814	Major facilitator Superfamily
MK616_RS18340	COG0833	amino acid
MK616_RS18345	COG4187	Peptidase family M20/M25/M40
MK616_RS18350	COG1012	belongs to the aldehyde dehydrogenase family
MK616_RS18355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MK616_RS18360	COG2205	protein histidine kinase activity
MK616_RS18365	COG0745	RESPONSE REGULATOR receiver
MK616_RS18380	COG1131	(ABC) transporter
MK616_RS18385	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
MK616_RS18390	COG1091	dTDP-4-dehydrorhamnose reductase activity
MK616_RS18395	COG1088	dTDP-glucose 4,6-dehydratase activity
MK616_RS18400	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MK616_RS18405	COG3980	spore coat polysaccharide biosynthesis protein
MK616_RS18410	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
MK616_RS18415	COG2089	acid synthase
MK616_RS18420	COG0456	acetyltransferase
MK616_RS18425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MK616_RS18430	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MK616_RS18435	COG0463	Glycosyl transferase, family 2
MK616_RS18445	COG2363	Small membrane protein
MK616_RS18450	COG2233	PERMEase
MK616_RS18465	COG1216	Glycosyl transferase, family 2
MK616_RS18480	COG1695	Transcriptional regulator
MK616_RS18485	COG0351	phosphomethylpyrimidine kinase
MK616_RS18495	COG1621	beta-fructofuranosidase activity
MK616_RS18500	COG1263	PTS System
MK616_RS18500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MK616_RS18505	COG3711	transcriptional antiterminator
MK616_RS18515	COG1404	Belongs to the peptidase S8 family
MK616_RS18520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MK616_RS18525	COG0778	Nitroreductase
MK616_RS18530	COG0772	Belongs to the SEDS family
MK616_RS18535	COG0454	-acetyltransferase
MK616_RS18555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MK616_RS18560	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MK616_RS18565	COG2261	transglycosylase associated protein
MK616_RS18570	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MK616_RS18575	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MK616_RS18580	COG2246	polysaccharide biosynthetic process
MK616_RS18585	COG1309	transcriptional regulator
MK616_RS18605	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MK616_RS18610	COG2837	iron assimilation
MK616_RS18630	COG0583	DNA-binding transcription factor activity
MK616_RS18640	COG1346	cytolysis
MK616_RS18645	COG4895	conserved protein (DUF2196)
MK616_RS18650	COG0789	Transcriptional regulator
MK616_RS18655	COG5504	Zn-dependent protease
MK616_RS18660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MK616_RS18665	COG0346	lactoylglutathione lyase activity
MK616_RS18670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MK616_RS18675	COG1404	Belongs to the peptidase S8 family
MK616_RS18680	COG1442	glycosyl transferase family 8
MK616_RS18685	COG1846	Transcriptional regulator
MK616_RS18690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MK616_RS18695	COG2357	RelA SpoT domain protein
MK616_RS18700	COG1575	Belongs to the MenA family. Type 1 subfamily
MK616_RS18715	COG1696	Membrane protein involved in D-alanine export
MK616_RS18725	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MK616_RS18730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MK616_RS18735	COG1486	melibiose metabolic process
MK616_RS18740	COG1447	Phosphotransferase system cellobiose-specific component IIA
MK616_RS18745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MK616_RS18750	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MK616_RS18755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MK616_RS18755	COG3711	transcriptional antiterminator
MK616_RS18765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MK616_RS18770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MK616_RS18780	COG0640	Transcriptional regulator
MK616_RS18785	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MK616_RS18790	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MK616_RS18795	COG1447	Phosphotransferase system cellobiose-specific component IIA
MK616_RS18800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MK616_RS18805	COG2723	6-phospho-beta-galactosidase activity
MK616_RS18810	COG1940	carbohydrate kinase activity
MK616_RS18815	COG1482	cell wall glycoprotein biosynthetic process
MK616_RS18825	COG0753	catalase activity
MK616_RS18830	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
MK616_RS18835	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MK616_RS18840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MK616_RS18845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MK616_RS18850	COG4988	ABC transporter
MK616_RS18855	COG1294	oxidase, subunit
MK616_RS18860	COG1271	oxidase subunit
MK616_RS18865	COG3493	citrate carrier protein
MK616_RS18870	COG0726	polysaccharide deacetylase
MK616_RS18875	COG3842	ATPase activity
MK616_RS18880	COG2508	Transcriptional regulator
MK616_RS18885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MK616_RS18895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MK616_RS18910	COG4894	glucomannan catabolic process
MK616_RS18915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MK616_RS18920	COG0500	methyltransferase
MK616_RS18925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MK616_RS18940	COG0753	catalase activity
MK616_RS18940	COG0693	protein deglycase activity
MK616_RS18945	COG2851	Citrate transporter
MK616_RS18950	COG2273	Hydrolase Family 16
MK616_RS18955	COG3711	transcriptional antiterminator
MK616_RS18960	COG2270	Major facilitator Superfamily
MK616_RS18965	COG0513	Belongs to the DEAD box helicase family
MK616_RS19020	COG0697	spore germination
MK616_RS19025	COG0589	response to stress
MK616_RS19035	COG0494	nUDIX hydrolase
MK616_RS19040	COG3507	Belongs to the glycosyl hydrolase 43 family
MK616_RS19065	COG0010	Belongs to the arginase family
MK616_RS19070	COG0833	amino acid
MK616_RS19075	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MK616_RS19080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MK616_RS19090	COG2390	Transcriptional regulator
MK616_RS19095	COG0561	phosphatase activity
MK616_RS19125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MK616_RS19130	COG5294	Protein conserved in bacteria
MK616_RS19135	COG0577	efflux transmembrane transporter activity
MK616_RS19140	COG1136	(ABC) transporter
MK616_RS19145	COG2205	protein histidine kinase activity
MK616_RS19150	COG0745	RESPONSE REGULATOR receiver
MK616_RS19155	COG2205	protein histidine kinase activity
MK616_RS19160	COG0745	RESPONSE REGULATOR receiver
MK616_RS19190	COG1082	Xylose isomerase domain protein TIM barrel
MK616_RS19200	COG2814	Major facilitator Superfamily
MK616_RS19230	COG1349	DNA-binding transcription factor activity
MK616_RS19235	COG0667	Aldo Keto reductase
MK616_RS19240	COG2814	Major facilitator Superfamily
MK616_RS19255	COG1028	Short-chain dehydrogenase reductase Sdr
MK616_RS19260	COG2197	response regulator
MK616_RS19265	COG4585	Histidine kinase
MK616_RS19270	COG3239	Fatty acid desaturase
MK616_RS19275	COG1309	transcriptional regulator
MK616_RS19280	COG1012	belongs to the aldehyde dehydrogenase family
MK616_RS19285	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MK616_RS19295	COG0640	Transcriptional regulator
MK616_RS19300	COG2814	Major facilitator Superfamily
MK616_RS19305	COG1714	RDD family
MK616_RS19315	COG0501	Belongs to the peptidase M48B family
MK616_RS19320	COG1715	Restriction endonuclease
MK616_RS19325	COG0450	alkyl hydroperoxide reductase
MK616_RS19330	COG3634	alkyl hydroperoxide reductase activity
MK616_RS19335	COG3177	Filamentation induced by cAMP protein fic
MK616_RS19340	COG1113	amino acid transport
MK616_RS19350	COG2080	2 iron, 2 sulfur cluster binding
MK616_RS19365	COG2068	MobA-Related Protein
MK616_RS19370	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MK616_RS19425	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
MK616_RS19430	COG0667	Aldo Keto reductase
MK616_RS19435	COG0456	acetyltransferase
MK616_RS19440	COG0457	Tetratricopeptide repeat
MK616_RS19445	COG0010	Belongs to the arginase family
MK616_RS19450	COG0833	amino acid
MK616_RS19455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MK616_RS19460	COG3829	transcription factor binding
MK616_RS19470	COG0488	(ABC) transporter
MK616_RS19485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MK616_RS19490	COG3850	Histidine kinase
MK616_RS19490	COG5002	protein histidine kinase activity
MK616_RS19495	COG0745	RESPONSE REGULATOR receiver
MK616_RS19505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MK616_RS19510	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MK616_RS19515	COG4853	Protein conserved in bacteria
MK616_RS19520	COG4863	YycH protein
MK616_RS19525	COG5002	protein histidine kinase activity
MK616_RS19530	COG0745	RESPONSE REGULATOR receiver
MK616_RS19560	COG0346	lactoylglutathione lyase activity
MK616_RS19565	COG0305	Participates in initiation and elongation during chromosome replication
MK616_RS19580	COG3093	addiction module antidote protein HigA
MK616_RS19585	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MK616_RS19590	COG0297	glycogen (starch) synthase activity
MK616_RS19600	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MK616_RS19605	COG0438	transferase activity, transferring glycosyl groups
MK616_RS19615	COG2112	serine threonine protein kinase
MK616_RS19625	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MK616_RS19630	COG4241	membrane
MK616_RS19640	COG5577	PFAM Coat F domain
MK616_RS19645	COG1733	regulation of RNA biosynthetic process
MK616_RS19655	COG0697	spore germination
MK616_RS19660	COG1621	beta-fructofuranosidase activity
MK616_RS19665	COG1621	beta-fructofuranosidase activity
MK616_RS19670	COG1802	Transcriptional regulator
MK616_RS19675	COG2318	DinB family
MK616_RS19680	COG2211	Major facilitator Superfamily
MK616_RS19685	COG0697	spore germination
MK616_RS19695	COG0778	Nitroreductase
MK616_RS19700	COG1846	Transcriptional regulator
MK616_RS19705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MK616_RS19710	COG1846	Transcriptional regulator
MK616_RS19715	COG2153	protein acetylation
MK616_RS19725	COG0546	phosphoglycolate phosphatase activity
MK616_RS19755	COG1404	Belongs to the peptidase S8 family
MK616_RS19765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MK616_RS19770	COG0697	spore germination
MK616_RS19775	COG1078	dGTPase activity
MK616_RS19790	COG4978	Transcriptional regulator
MK616_RS19790	COG0789	Transcriptional regulator
MK616_RS19795	COG1811	Na channel or pump
MK616_RS19805	COG1266	CAAX protease self-immunity
MK616_RS19810	COG0477	Major facilitator Superfamily
MK616_RS19810	COG2814	Major facilitator Superfamily
MK616_RS19815	COG0346	lactoylglutathione lyase activity
MK616_RS19820	COG1609	Transcriptional regulator
MK616_RS19825	COG0708	Exodeoxyribonuclease III
MK616_RS19835	COG0708	Exodeoxyribonuclease III
MK616_RS19840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MK616_RS19845	COG2169	Transcriptional regulator
MK616_RS19855	COG0629	single-stranded DNA binding
MK616_RS19865	COG0012	GTP binding
MK616_RS19870	COG0243	molybdopterin cofactor binding
MK616_RS19875	COG4481	Protein conserved in bacteria
MK616_RS19880	COG3949	Membrane
MK616_RS19895	COG1475	DNA binding
MK616_RS19900	COG1192	Involved in chromosome partitioning
MK616_RS19925	COG1847	R3H domain protein
MK616_RS19930	COG0706	membrane insertase activity