locus-tag	class	description
DIR45_RS00010	COG0592	DNA-directed DNA polymerase activity
DIR45_RS00015	COG2501	S4 domain
DIR45_RS00025	COG0187	DNA topoisomerase II activity
DIR45_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DIR45_RS00065	COG0516	GMP reductase activity
DIR45_RS00065	COG0517	IMP dehydrogenase activity
DIR45_RS00070	COG1686	Belongs to the peptidase S11 family
DIR45_RS00100	COG1428	Deoxynucleoside kinase
DIR45_RS00105	COG1428	Deoxynucleoside kinase
DIR45_RS00110	COG1335	isochorismatase
DIR45_RS00115	COG0590	tRNA wobble adenosine to inosine editing
DIR45_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DIR45_RS00180	COG1982	Orn Lys Arg decarboxylase major
DIR45_RS00190	COG0470	DNA polymerase III
DIR45_RS00195	COG1774	PSP1 C-terminal conserved region
DIR45_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DIR45_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DIR45_RS00220	COG2002	toxin-antitoxin pair type II binding
DIR45_RS00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DIR45_RS00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DIR45_RS00230	COG0084	hydrolase, TatD family'
DIR45_RS00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DIR45_RS00250	COG4466	Protein conserved in bacteria
DIR45_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DIR45_RS00270	COG0251	oxidation-reduction process
DIR45_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DIR45_RS00305	COG2002	toxin-antitoxin pair type II binding
DIR45_RS00310	COG2244	polysaccharide biosynthetic process
DIR45_RS00315	COG3956	TIGRFAM MazG family protein
DIR45_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DIR45_RS00340	COG1098	S1 RNA binding domain
DIR45_RS00355	COG2208	phosphoserine phosphatase activity
DIR45_RS00360	COG0037	tRNA processing
DIR45_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DIR45_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DIR45_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DIR45_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DIR45_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
DIR45_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DIR45_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DIR45_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DIR45_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DIR45_RS00420	COG1396	sequence-specific DNA binding
DIR45_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DIR45_RS00455	COG3880	PFAM UvrB UvrC protein
DIR45_RS00465	COG0542	response to heat
DIR45_RS00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DIR45_RS00480	COG4956	integral membrane protein (PIN domain superfamily)
DIR45_RS00500	COG1045	serine acetyltransferase
DIR45_RS00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DIR45_RS00520	COG3688	RNA-binding protein containing a PIN domain
DIR45_RS00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DIR45_RS00540	COG0250	Participates in transcription elongation, termination and antitermination
DIR45_RS00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DIR45_RS00565	COG2813	Specifically methylates the guanine in position
DIR45_RS00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DIR45_RS00580	COG1358	cellular component organization or biogenesis
DIR45_RS00650	COG0255	Belongs to the universal ribosomal protein uL29 family
DIR45_RS00710	COG0201	protein transport
DIR45_RS00720	COG0024	Methionine aminopeptidase
DIR45_RS00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DIR45_RS00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DIR45_RS00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
DIR45_RS00795	COG0489	protein tyrosine kinase activity
DIR45_RS00805	COG2194	sulfuric ester hydrolase activity
DIR45_RS00810	COG0726	polysaccharide deacetylase
DIR45_RS00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DIR45_RS00895	COG4856	YbbR-like protein
DIR45_RS00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DIR45_RS00915	COG0596	Alpha beta hydrolase
DIR45_RS00935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DIR45_RS00945	COG0823	Involved in the tonB-independent uptake of proteins
DIR45_RS00945	COG1506	peptidase
DIR45_RS00945	COG4946	Tricorn protease homolog
DIR45_RS00980	COG2011	ABC-type metal ion transport system permease component
DIR45_RS00985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DIR45_RS00990	COG1464	Belongs to the NlpA lipoprotein family
DIR45_RS00995	COG0604	alcohol dehydrogenase
DIR45_RS01010	COG2271	Major facilitator Superfamily
DIR45_RS01020	COG2814	Major facilitator Superfamily
DIR45_RS01035	COG0601	transmembrane transport
DIR45_RS01040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DIR45_RS01045	COG0444	Belongs to the ABC transporter superfamily
DIR45_RS01050	COG4608	Belongs to the ABC transporter superfamily
DIR45_RS01055	COG4166	transmembrane transport
DIR45_RS01065	COG2207	Transcriptional regulator
DIR45_RS01080	COG4166	transmembrane transport
DIR45_RS01085	COG4166	transmembrane transport
DIR45_RS01090	COG0656	L-ascorbic acid biosynthetic process
DIR45_RS01095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DIR45_RS01110	COG4149	molybdate abc transporter
DIR45_RS01115	COG0725	ABC transporter, periplasmic molybdate-binding protein
DIR45_RS01120	COG1910	domain protein
DIR45_RS01130	COG0583	DNA-binding transcription factor activity
DIR45_RS01135	COG0697	spore germination
DIR45_RS01150	COG0204	Acyl-transferase
DIR45_RS01160	COG1609	Transcriptional regulator
DIR45_RS01170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_RS01180	COG0084	hydrolase, TatD family'
DIR45_RS01185	COG5298	Protein conserved in bacteria
DIR45_RS01205	COG0488	(ABC) transporter
DIR45_RS01220	COG0747	negative chemotaxis
DIR45_RS01225	COG0601	transmembrane transport
DIR45_RS01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DIR45_RS01235	COG0444	Belongs to the ABC transporter superfamily
DIR45_RS01240	COG4608	Belongs to the ABC transporter superfamily
DIR45_RS01275	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DIR45_RS01280	COG0179	Fumarylacetoacetate (FAA) hydrolase
DIR45_RS01290	COG2814	Major facilitator Superfamily
DIR45_RS01300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DIR45_RS01310	COG4294	response to UV
DIR45_RS01315	COG0705	Rhomboid family
DIR45_RS01315	COG0457	Tetratricopeptide repeat
DIR45_RS01325	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DIR45_RS01330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DIR45_RS01335	COG0864	Transcriptional regulator
DIR45_RS01340	COG2337	Toxic component of a toxin-antitoxin (TA) module
DIR45_RS01345	COG2183	response to ionizing radiation
DIR45_RS01440	COG0802	atpase or kinase
DIR45_RS01445	COG1214	PFAM Peptidase M22, glycoprotease
DIR45_RS01450	COG0456	acetyltransferase
DIR45_RS01460	COG0488	(ABC) transporter
DIR45_RS01475	COG1266	CAAX protease self-immunity
DIR45_RS01495	COG2252	PERMEase
DIR45_RS01505	COG5002	protein histidine kinase activity
DIR45_RS01530	COG1968	undecaprenyl-diphosphatase activity
DIR45_RS01545	COG2205	protein histidine kinase activity
DIR45_RS01550	COG0745	RESPONSE REGULATOR receiver
DIR45_RS01575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DIR45_RS01580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DIR45_RS01585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DIR45_RS01595	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DIR45_RS01610	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DIR45_RS01620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DIR45_RS01630	COG0151	Belongs to the GarS family
DIR45_RS01655	COG0210	DNA helicase
DIR45_RS01665	COG4851	CamS sex pheromone cAM373 precursor
DIR45_RS01680	COG1335	isochorismatase
DIR45_RS01690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DIR45_RS01695	COG2011	ABC-type metal ion transport system permease component
DIR45_RS01700	COG1464	Belongs to the NlpA lipoprotein family
DIR45_RS01720	COG1846	Transcriptional regulator
DIR45_RS01745	COG1597	lipid kinase activity
DIR45_RS01750	COG0546	phosphoglycolate phosphatase activity
DIR45_RS01755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DIR45_RS01765	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_RS01770	COG2076	Multidrug Resistance protein
DIR45_RS01775	COG2309	aminopeptidase activity
DIR45_RS01790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DIR45_RS01795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DIR45_RS01800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DIR45_RS01810	COG4807	Protein conserved in bacteria
DIR45_RS01835	COG1757	Na H antiporter
DIR45_RS01840	COG1473	amidohydrolase
DIR45_RS01855	COG0450	alkyl hydroperoxide reductase
DIR45_RS01875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_RS01880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_RS01885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DIR45_RS01910	COG0166	Belongs to the GPI family
DIR45_RS01950	COG5002	protein histidine kinase activity
DIR45_RS01970	COG3541	Predicted nucleotidyltransferase
DIR45_RS01975	COG2814	Major facilitator Superfamily
DIR45_RS01980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DIR45_RS01980	COG0723	plastoquinol--plastocyanin reductase activity
DIR45_RS01990	COG0765	amino acid transport
DIR45_RS01995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DIR45_RS02010	COG0840	transmembrane signaling receptor activity
DIR45_RS02015	COG0840	transmembrane signaling receptor activity
DIR45_RS02020	COG0366	Alpha amylase catalytic
DIR45_RS02025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DIR45_RS02025	COG2190	(PTS) system
DIR45_RS02025	COG1263	PTS System
DIR45_RS02055	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DIR45_RS02070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DIR45_RS02080	COG1116	anion transmembrane transporter activity
DIR45_RS02085	COG0488	(ABC) transporter
DIR45_RS02130	COG2270	Major facilitator Superfamily
DIR45_RS02145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DIR45_RS02160	COG2310	stress, protein
DIR45_RS02165	COG2310	stress, protein
DIR45_RS02170	COG2310	stress, protein
DIR45_RS02175	COG0861	Integral membrane protein TerC family
DIR45_RS02185	COG3853	Toxic anion resistance protein (TelA)
DIR45_RS02200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DIR45_RS02210	COG1295	ribonuclease BN
DIR45_RS02215	COG2217	Heavy metal translocating P-type atpase
DIR45_RS02220	COG0697	spore germination
DIR45_RS02240	COG0586	Pfam SNARE associated Golgi protein
DIR45_RS02255	COG3871	stress protein (general stress protein 26)
DIR45_RS02260	COG0387	Pfam Sodium calcium exchanger
DIR45_RS02270	COG0535	radical SAM domain protein
DIR45_RS02295	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DIR45_RS02300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DIR45_RS02305	COG0582	viral genome integration into host DNA
DIR45_RS02310	COG1396	sequence-specific DNA binding
DIR45_RS02330	COG1396	sequence-specific DNA binding
DIR45_RS02360	COG1484	DNA-dependent DNA replication
DIR45_RS02445	COG0582	viral genome integration into host DNA
DIR45_RS02450	COG0582	viral genome integration into host DNA
DIR45_RS02570	COG0101	tRNA pseudouridine synthase activity
DIR45_RS02580	COG3829	transcription factor binding
DIR45_RS02590	COG0833	amino acid
DIR45_RS02595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DIR45_RS02625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DIR45_RS02625	COG1263	PTS System
DIR45_RS02630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DIR45_RS02645	COG0463	Glycosyl transferase, family 2
DIR45_RS02660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DIR45_RS02660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DIR45_RS02680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DIR45_RS02700	COG1228	amidohydrolase
DIR45_RS02705	COG1090	epimerase
DIR45_RS02735	COG1988	membrane-bound metal-dependent
DIR45_RS02740	COG1194	a g-specific adenine glycosylase
DIR45_RS02765	COG1132	(ABC) transporter
DIR45_RS02770	COG4129	membrane
DIR45_RS02775	COG0067	glutamate synthase
DIR45_RS02775	COG0069	glutamate synthase activity
DIR45_RS02775	COG0070	glutamate synthase
DIR45_RS02785	COG4555	ABC transporter
DIR45_RS02805	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DIR45_RS02810	COG0735	belongs to the Fur family
DIR45_RS02925	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DIR45_RS02930	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DIR45_RS02940	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DIR45_RS02950	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DIR45_RS02960	COG2766	serine protein kinase
DIR45_RS02980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DIR45_RS02990	COG1585	Membrane protein implicated in regulation of membrane protease activity
DIR45_RS02995	COG2268	Band 7 protein
DIR45_RS03005	COG3290	protein histidine kinase activity
DIR45_RS03010	COG4565	transcriptional regulatory protein
DIR45_RS03015	COG2851	Citrate transporter
DIR45_RS03040	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DIR45_RS03045	COG3842	ATPase activity
DIR45_RS03050	COG1175	transmembrane transport
DIR45_RS03055	COG0395	ABC-type sugar transport system, permease component
DIR45_RS03065	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DIR45_RS03070	COG0745	RESPONSE REGULATOR receiver
DIR45_RS03075	COG5002	protein histidine kinase activity
DIR45_RS03085	COG4990	cell redox homeostasis
DIR45_RS03095	COG3290	protein histidine kinase activity
DIR45_RS03100	COG4565	transcriptional regulatory protein
DIR45_RS03105	COG3493	citrate carrier protein
DIR45_RS03110	COG0281	malic enzyme
DIR45_RS03125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIR45_RS03135	COG5002	protein histidine kinase activity
DIR45_RS03140	COG0745	RESPONSE REGULATOR receiver
DIR45_RS03145	COG0454	-acetyltransferase
DIR45_RS03145	COG0456	acetyltransferase
DIR45_RS03150	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DIR45_RS03155	COG3383	formate dehydrogenase (NAD+) activity
DIR45_RS03160	COG2427	Protein of unknown function (DUF1641)
DIR45_RS03175	COG0531	amino acid
DIR45_RS03180	COG0640	Transcriptional regulator
DIR45_RS03185	COG2217	Heavy metal translocating P-type atpase
DIR45_RS03190	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DIR45_RS03205	COG3227	Zinc metalloprotease (Elastase)
DIR45_RS03225	COG2720	vancomycin resistance protein
DIR45_RS03230	COG1316	TRANSCRIPTIONal
DIR45_RS03235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DIR45_RS03240	COG0346	lactoylglutathione lyase activity
DIR45_RS03245	COG1253	flavin adenine dinucleotide binding
DIR45_RS03250	COG1027	Aspartate ammonia-lyase
DIR45_RS03255	COG1620	l-lactate permease
DIR45_RS03270	COG3104	oligopeptide transport
DIR45_RS03275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DIR45_RS03280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_RS03285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_RS03295	COG2226	methyltransferase
DIR45_RS03300	COG0156	8-amino-7-oxononanoate synthase activity
DIR45_RS03305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DIR45_RS03315	COG4548	von Willebrand factor, type A
DIR45_RS03320	COG0714	Associated with various cellular activities
DIR45_RS03325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DIR45_RS03345	COG0531	amino acid
DIR45_RS03350	COG2188	Transcriptional regulator
DIR45_RS03355	COG1263	PTS System
DIR45_RS03355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DIR45_RS03360	COG0366	Alpha amylase catalytic
DIR45_RS03375	COG0697	spore germination
DIR45_RS03385	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DIR45_RS03390	COG1115	amino acid carrier protein
DIR45_RS03395	COG1126	abc transporter atp-binding protein
DIR45_RS03400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DIR45_RS03405	COG0765	amino acid transport
DIR45_RS03410	COG0765	amino acid transport
DIR45_RS03415	COG0833	amino acid
DIR45_RS03440	COG2378	regulation of single-species biofilm formation
DIR45_RS03445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DIR45_RS03450	COG5002	protein histidine kinase activity
DIR45_RS03465	COG0659	secondary active sulfate transmembrane transporter activity
DIR45_RS03480	COG0747	negative chemotaxis
DIR45_RS03490	COG0601	transmembrane transport
DIR45_RS03495	COG4608	Belongs to the ABC transporter superfamily
DIR45_RS03505	COG2271	Major facilitator Superfamily
DIR45_RS03510	COG1846	Transcriptional regulator
DIR45_RS03520	COG1609	Transcriptional regulator
DIR45_RS03525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DIR45_RS03540	COG1172	Belongs to the binding-protein-dependent transport system permease family
DIR45_RS03545	COG1879	ABC-type sugar transport system periplasmic component
DIR45_RS03570	COG1063	alcohol dehydrogenase
DIR45_RS03585	COG3568	Endonuclease Exonuclease Phosphatase
DIR45_RS03610	COG1968	undecaprenyl-diphosphatase activity
DIR45_RS03615	COG0840	transmembrane signaling receptor activity
DIR45_RS03620	COG3584	3D domain protein
DIR45_RS03620	COG1388	LysM domain
DIR45_RS03625	COG1476	TRANSCRIPTIONal
DIR45_RS03640	COG3104	oligopeptide transport
DIR45_RS03645	COG1114	Component of the transport system for branched-chain amino acids
DIR45_RS03660	COG1113	amino acid transport
DIR45_RS03665	COG2252	PERMEase
DIR45_RS03690	COG0569	domain protein
DIR45_RS03690	COG0475	glutathione-regulated potassium exporter activity
DIR45_RS03705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DIR45_RS03710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DIR45_RS03715	COG0833	amino acid
DIR45_RS03720	COG4990	cell redox homeostasis
DIR45_RS03735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DIR45_RS03740	COG0697	spore germination
DIR45_RS03745	COG0531	amino acid
DIR45_RS03755	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DIR45_RS03760	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DIR45_RS03765	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DIR45_RS03765	COG1918	ferrous iron import across plasma membrane
DIR45_RS03770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DIR45_RS03775	COG0573	inorganic phosphate transmembrane transporter activity
DIR45_RS03780	COG0581	inorganic phosphate transmembrane transporter activity
DIR45_RS03790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DIR45_RS03910	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DIR45_RS03930	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DIR45_RS03935	COG1116	anion transmembrane transporter activity
DIR45_RS03940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DIR45_RS03945	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DIR45_RS03950	COG0352	thiamine-phosphate diphosphorylase activity
DIR45_RS03955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DIR45_RS03960	COG2104	thiamine diphosphate biosynthetic process
DIR45_RS03970	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DIR45_RS03975	COG0351	phosphomethylpyrimidine kinase
DIR45_RS04015	COG2205	protein histidine kinase activity
DIR45_RS04020	COG2814	Major facilitator Superfamily
DIR45_RS04025	COG1846	Transcriptional regulator
DIR45_RS04040	COG2252	PERMEase
DIR45_RS04045	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_RS04050	COG1376	ErfK ybiS ycfS ynhG family protein
DIR45_RS04060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DIR45_RS04065	COG1621	beta-fructofuranosidase activity
DIR45_RS04070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DIR45_RS04070	COG1263	PTS System
DIR45_RS04075	COG1609	Transcriptional regulator
DIR45_RS04085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DIR45_RS04125	COG0778	Nitroreductase
DIR45_RS04130	COG2719	SpoVR family
DIR45_RS04155	COG0446	pyridine nucleotide-disulphide oxidoreductase
DIR45_RS04160	COG1937	Protein conserved in bacteria
DIR45_RS04165	COG0425	Belongs to the sulfur carrier protein TusA family
DIR45_RS04165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DIR45_RS04170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DIR45_RS04170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_RS04175	COG0425	Belongs to the sulfur carrier protein TusA family
DIR45_RS04180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DIR45_RS04190	COG2210	Belongs to the sulfur carrier protein TusA family
DIR45_RS04195	COG0730	response to heat
DIR45_RS04205	COG1316	TRANSCRIPTIONal
DIR45_RS04210	COG0604	alcohol dehydrogenase
DIR45_RS04215	COG1283	sodium-dependent phosphate transmembrane transporter activity
DIR45_RS04230	COG3711	transcriptional antiterminator
DIR45_RS04230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DIR45_RS04235	COG1447	Phosphotransferase system cellobiose-specific component IIA
DIR45_RS04240	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DIR45_RS04260	COG3584	3D domain protein
DIR45_RS04260	COG1388	LysM domain
DIR45_RS04265	COG0577	efflux transmembrane transporter activity
DIR45_RS04270	COG1136	(ABC) transporter
DIR45_RS04280	COG5522	Integral membrane protein (intg_mem_TP0381)
DIR45_RS04295	COG1114	Component of the transport system for branched-chain amino acids
DIR45_RS04300	COG3546	catalase activity
DIR45_RS04335	COG0586	Pfam SNARE associated Golgi protein
DIR45_RS04365	COG0531	amino acid
DIR45_RS04370	COG0475	glutathione-regulated potassium exporter activity
DIR45_RS04380	COG1737	Transcriptional regulator
DIR45_RS04390	COG1263	PTS System
DIR45_RS04390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DIR45_RS04400	COG2259	Doxx family
DIR45_RS04415	COG0697	spore germination
DIR45_RS04420	COG1522	sequence-specific DNA binding
DIR45_RS04435	COG2076	Multidrug Resistance protein
DIR45_RS04440	COG1309	transcriptional regulator
DIR45_RS04445	COG2814	Major facilitator Superfamily
DIR45_RS04450	COG1733	regulation of RNA biosynthetic process
DIR45_RS04460	COG2249	NAD(P)H dehydrogenase (quinone) activity
DIR45_RS04465	COG4533	DNA binding
DIR45_RS04470	COG2211	Major facilitator Superfamily
DIR45_RS04480	COG0693	protein deglycase activity
DIR45_RS04485	COG0693	protein deglycase activity
DIR45_RS04485	COG0753	catalase activity
DIR45_RS04495	COG0531	amino acid
DIR45_RS04500	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DIR45_RS04510	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_RS04525	COG1132	(ABC) transporter
DIR45_RS04540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DIR45_RS04545	COG0765	amino acid transport
DIR45_RS04550	COG1126	abc transporter atp-binding protein
DIR45_RS04565	COG0189	ligase activity
DIR45_RS04595	COG0028	Belongs to the TPP enzyme family
DIR45_RS04600	COG3527	Alpha-acetolactate decarboxylase
DIR45_RS04615	COG0561	phosphatase activity
DIR45_RS04630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DIR45_RS04645	COG0659	secondary active sulfate transmembrane transporter activity
DIR45_RS04665	COG0653	protein targeting
DIR45_RS04670	COG2244	polysaccharide biosynthetic process
DIR45_RS04680	COG0860	N-Acetylmuramoyl-L-alanine amidase
DIR45_RS04685	COG4196	transglutaminase domain protein
DIR45_RS04700	COG1696	Membrane protein involved in D-alanine export
DIR45_RS04715	COG1024	Enoyl-CoA hydratase
DIR45_RS04730	COG1363	Peptidase, m42
DIR45_RS04750	COG3938	Belongs to the proline racemase family
DIR45_RS04780	COG0601	transmembrane transport
DIR45_RS04785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DIR45_RS04795	COG4608	Belongs to the ABC transporter superfamily
DIR45_RS04800	COG0322	excinuclease ABC activity
DIR45_RS04830	COG0477	Major facilitator Superfamily
DIR45_RS04835	COG3290	protein histidine kinase activity
DIR45_RS04840	COG4565	transcriptional regulatory protein
DIR45_RS04845	COG3181	Tripartite tricarboxylate transporter family receptor
DIR45_RS04875	COG0789	Transcriptional regulator
DIR45_RS04875	COG4978	Transcriptional regulator
DIR45_RS04890	COG0305	Participates in initiation and elongation during chromosome replication
DIR45_RS04925	COG0477	Major facilitator Superfamily
DIR45_RS04975	COG1309	transcriptional regulator
DIR45_RS04995	COG1183	phosphatidylcholine synthase activity
DIR45_RS05020	COG2376	Dihydroxyacetone kinase
DIR45_RS05035	COG2376	Dihydroxyacetone kinase
DIR45_RS05040	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DIR45_RS05045	COG1959	2 iron, 2 sulfur cluster binding
DIR45_RS05075	COG2770	Histidine kinase
DIR45_RS05075	COG3437	response regulator, receiver
DIR45_RS05130	COG3237	CsbD-like
DIR45_RS05155	COG1191	sigma factor activity
DIR45_RS05165	COG2208	phosphoserine phosphatase activity
DIR45_RS05170	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DIR45_RS05175	COG2205	protein histidine kinase activity
DIR45_RS05175	COG2198	Histidine kinase
DIR45_RS05175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DIR45_RS05175	COG0784	Response regulator, receiver
DIR45_RS05230	COG0420	3'-5' exonuclease activity
DIR45_RS05255	COG1309	transcriptional regulator
DIR45_RS05260	COG2814	Major facilitator Superfamily
DIR45_RS05265	COG0346	lactoylglutathione lyase activity
DIR45_RS05270	COG0346	lactoylglutathione lyase activity
DIR45_RS05275	COG0457	Tetratricopeptide repeat
DIR45_RS05280	COG2267	carboxylic ester hydrolase activity
DIR45_RS05300	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DIR45_RS05305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DIR45_RS05315	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DIR45_RS05350	COG0477	Major facilitator Superfamily
DIR45_RS05355	COG0477	Major facilitator Superfamily
DIR45_RS05365	COG3973	AAA domain
DIR45_RS05370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DIR45_RS05390	COG4980	gas vesicle protein
DIR45_RS05395	COG0537	adenosine 5'-monophosphoramidase activity
DIR45_RS05400	COG1131	(ABC) transporter
DIR45_RS05405	COG4473	ABC transporter
DIR45_RS05420	COG1309	transcriptional regulator
DIR45_RS05425	COG3402	PFAM membrane-flanked domain
DIR45_RS05475	COG3402	PFAM membrane-flanked domain
DIR45_RS05480	COG3428	Bacterial PH domain
DIR45_RS05485	COG2329	Antibiotic biosynthesis monooxygenase
DIR45_RS05490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DIR45_RS05495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DIR45_RS05500	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DIR45_RS05505	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DIR45_RS05540	COG1309	transcriptional regulator
DIR45_RS05545	COG1511	domain protein
DIR45_RS05570	COG1609	Transcriptional regulator
DIR45_RS05580	COG1234	tRNA 3'-trailer cleavage
DIR45_RS05585	COG0095	Lipoate-protein ligase
DIR45_RS05595	COG0318	PFAM AMP-dependent synthetase and ligase
DIR45_RS05625	COG3209	COG3209 Rhs family protein
DIR45_RS05660	COG1078	dGTPase activity
DIR45_RS05670	COG1595	DNA-templated transcription, initiation
DIR45_RS05675	COG3708	Transcriptional regulator
DIR45_RS05675	COG2207	Transcriptional regulator
DIR45_RS05685	COG2205	protein histidine kinase activity
DIR45_RS05690	COG0745	RESPONSE REGULATOR receiver
DIR45_RS05715	COG0501	Belongs to the peptidase M48B family
DIR45_RS05720	COG0840	transmembrane signaling receptor activity
DIR45_RS05725	COG0697	spore germination
DIR45_RS05745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DIR45_RS05750	COG2224	Isocitrate lyase
DIR45_RS05775	COG4903	ComK protein
DIR45_RS05780	COG0398	Pfam SNARE associated Golgi protein
DIR45_RS05790	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DIR45_RS05795	COG1074	ATP-dependent DNA helicase activity
DIR45_RS05840	COG0179	Fumarylacetoacetate (FAA) hydrolase
DIR45_RS05865	COG0367	asparagine synthase
DIR45_RS05870	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DIR45_RS05875	COG0753	catalase activity
DIR45_RS05880	COG0004	ammonium transporteR
DIR45_RS05905	COG2996	Protein conserved in bacteria
DIR45_RS05915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DIR45_RS05925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_RS05940	COG0561	phosphatase activity
DIR45_RS05950	COG0542	response to heat
DIR45_RS05960	COG2267	carboxylic ester hydrolase activity
DIR45_RS05975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DIR45_RS05980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DIR45_RS05985	COG5504	Zn-dependent protease
DIR45_RS05995	COG0180	Tryptophanyl-tRNA synthetase
DIR45_RS06010	COG4166	transmembrane transport
DIR45_RS06015	COG0601	transmembrane transport
DIR45_RS06020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DIR45_RS06025	COG0444	Belongs to the ABC transporter superfamily
DIR45_RS06030	COG4608	Belongs to the ABC transporter superfamily
DIR45_RS06035	COG0534	Mate efflux family protein
DIR45_RS06040	COG4166	transmembrane transport
DIR45_RS06055	COG0861	Integral membrane protein TerC family
DIR45_RS06060	COG4862	establishment of competence for transformation
DIR45_RS06065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DIR45_RS06075	COG1164	Oligoendopeptidase f
DIR45_RS06080	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DIR45_RS06085	COG2346	COG2346, Truncated hemoglobins
DIR45_RS06090	COG4116	CYTH
DIR45_RS06100	COG2357	RelA SpoT domain protein
DIR45_RS06110	COG0564	pseudouridine synthase activity
DIR45_RS06130	COG1216	Glycosyl transferase, family 2
DIR45_RS06130	COG0463	Glycosyl transferase, family 2
DIR45_RS06170	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DIR45_RS06185	COG1091	dTDP-4-dehydrorhamnose reductase activity
DIR45_RS06230	COG2153	protein acetylation
DIR45_RS06240	COG2382	esterase
DIR45_RS06255	COG5492	domain, Protein
DIR45_RS06260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DIR45_RS06275	COG0512	Glutamine amidotransferase of anthranilate synthase
DIR45_RS06275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DIR45_RS06310	COG1620	l-lactate permease
DIR45_RS06315	COG5634	Uncharacterized conserved protein (DUF2278)
DIR45_RS06370	COG0508	dehydrogenase complex catalyzes the overall conversion of
DIR45_RS06380	COG1476	TRANSCRIPTIONal
DIR45_RS06440	COG2226	methyltransferase
DIR45_RS06450	COG1686	Belongs to the peptidase S11 family
DIR45_RS06455	COG0681	Belongs to the peptidase S26 family
DIR45_RS06490	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_RS06495	COG3842	ATPase activity
DIR45_RS06500	COG1176	ABC-type spermidine putrescine transport system, permease component I
DIR45_RS06505	COG1177	transmembrane transport
DIR45_RS06510	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DIR45_RS06520	COG2409	Drug exporters of the RND superfamily
DIR45_RS06530	COG0564	pseudouridine synthase activity
DIR45_RS06540	COG2340	Cysteine-rich secretory protein family
DIR45_RS06545	COG0247	lactate metabolic process
DIR45_RS06550	COG0277	FAD linked oxidase domain protein
DIR45_RS06555	COG3835	regulator
DIR45_RS06565	COG0745	RESPONSE REGULATOR receiver
DIR45_RS06570	COG5002	protein histidine kinase activity
DIR45_RS06575	COG2186	Transcriptional regulator
DIR45_RS06595	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DIR45_RS06605	COG2116	formate transmembrane transporter activity
DIR45_RS06610	COG0861	Integral membrane protein TerC family
DIR45_RS06625	COG2030	dehydratase
DIR45_RS06645	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_RS06650	COG3243	poly(R)-hydroxyalkanoic acid synthase
DIR45_RS06655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DIR45_RS06660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DIR45_RS06675	COG1840	ABC-type Fe3 transport system, periplasmic component
DIR45_RS06705	COG1349	DNA-binding transcription factor activity
DIR45_RS06725	COG2861	carbohydrate metabolic process
DIR45_RS06735	COG3852	Histidine kinase
DIR45_RS06740	COG1846	Transcriptional regulator
DIR45_RS06750	COG2318	DinB family
DIR45_RS06755	COG5002	protein histidine kinase activity
DIR45_RS06765	COG0720	synthase
DIR45_RS06780	COG4873	Protein conserved in bacteria
DIR45_RS06810	COG1780	Probably involved in ribonucleotide reductase function
DIR45_RS06830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DIR45_RS06835	COG1725	Transcriptional regulator
DIR45_RS06840	COG1131	(ABC) transporter
DIR45_RS06850	COG1131	(ABC) transporter
DIR45_RS06855	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DIR45_RS06870	COG1522	sequence-specific DNA binding
DIR45_RS06880	COG1335	isochorismatase
DIR45_RS06890	COG1619	proteins homologs of microcin C7 resistance protein MccF
DIR45_RS06895	COG2070	2-Nitropropane dioxygenase
DIR45_RS06900	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DIR45_RS06910	COG1696	Membrane protein involved in D-alanine export
DIR45_RS06930	COG0716	FMN binding
DIR45_RS06940	COG3173	Aminoglycoside phosphotransferase
DIR45_RS06955	COG0534	Mate efflux family protein
DIR45_RS06960	COG1968	undecaprenyl-diphosphatase activity
DIR45_RS06975	COG1846	Transcriptional regulator
DIR45_RS06985	COG1301	dicarboxylic acid transport
DIR45_RS06990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DIR45_RS06995	COG4709	membrane
DIR45_RS07000	COG3874	Sporulation protein YtfJ
DIR45_RS07025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DIR45_RS07030	COG0028	Belongs to the TPP enzyme family
DIR45_RS07035	COG0440	acetolactate synthase activity
DIR45_RS07040	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DIR45_RS07050	COG0473	3-isopropylmalate dehydrogenase activity
DIR45_RS07075	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DIR45_RS07110	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DIR45_RS07125	COG1183	phosphatidylcholine synthase activity
DIR45_RS07130	COG1368	sulfuric ester hydrolase activity
DIR45_RS07140	COG0019	diaminopimelate decarboxylase activity
DIR45_RS07160	COG0529	Catalyzes the synthesis of activated sulfate
DIR45_RS07165	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DIR45_RS07185	COG1648	precorrin-2 dehydrogenase activity
DIR45_RS07190	COG0733	neurotransmitter:sodium symporter activity
DIR45_RS07210	COG1757	Na H antiporter
DIR45_RS07225	COG4758	membrane
DIR45_RS07230	COG4585	Histidine kinase
DIR45_RS07235	COG2197	response regulator
DIR45_RS07245	COG1114	Component of the transport system for branched-chain amino acids
DIR45_RS07255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DIR45_RS07280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DIR45_RS07280	COG1017	nitric oxide dioxygenase activity
DIR45_RS07295	COG0730	response to heat
DIR45_RS07300	COG0306	phosphate transporter
DIR45_RS07305	COG1392	Phosphate transport regulator
DIR45_RS07310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DIR45_RS07330	COG1801	Protein of unknown function DUF72
DIR45_RS07340	COG0582	viral genome integration into host DNA
DIR45_RS07345	COG5002	protein histidine kinase activity
DIR45_RS07375	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DIR45_RS07375	COG0392	lysyltransferase activity
DIR45_RS07390	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DIR45_RS07395	COG1686	Belongs to the peptidase S11 family
DIR45_RS07400	COG2715	membrane protein required for spore maturation
DIR45_RS07405	COG0700	Nucleoside recognition
DIR45_RS07410	COG1187	pseudouridine synthase activity
DIR45_RS07420	COG1333	cytochrome c biogenesis protein
DIR45_RS07425	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DIR45_RS07430	COG0745	RESPONSE REGULATOR receiver
DIR45_RS07435	COG5002	protein histidine kinase activity
DIR45_RS07440	COG2096	Adenosyltransferase
DIR45_RS07455	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DIR45_RS07460	COG1141	Ferredoxin
DIR45_RS07465	COG4955	Helix-turn-helix domain
DIR45_RS07470	COG0514	ATP-dependent DNA helicase (RecQ)
DIR45_RS07475	COG1266	CAAX protease self-immunity
DIR45_RS07495	COG4862	establishment of competence for transformation
DIR45_RS07500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DIR45_RS07520	COG0492	ferredoxin-NADP+ reductase activity
DIR45_RS07590	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DIR45_RS07605	COG0142	geranyltranstransferase activity
DIR45_RS07615	COG0142	geranyltranstransferase activity
DIR45_RS07635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DIR45_RS07640	COG0457	Tetratricopeptide repeat
DIR45_RS07660	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DIR45_RS07670	COG4347	Protein of unknown function (DUF1405)
DIR45_RS07685	COG2738	Putative neutral zinc metallopeptidase
DIR45_RS07695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_RS07705	COG1694	Mazg nucleotide pyrophosphohydrolase
DIR45_RS07720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DIR45_RS07725	COG0438	transferase activity, transferring glycosyl groups
DIR45_RS07785	COG3935	DnaD domain protein
DIR45_RS07790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DIR45_RS07800	COG4499	WXG100 protein secretion system (Wss), protein YukC
DIR45_RS07800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DIR45_RS07860	COG0116	Belongs to the methyltransferase superfamily
DIR45_RS07870	COG1199	ATP-dependent helicase activity
DIR45_RS07875	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DIR45_RS07885	COG3173	Aminoglycoside phosphotransferase
DIR45_RS07890	COG0024	Methionine aminopeptidase
DIR45_RS07900	COG2233	PERMEase
DIR45_RS07905	COG2311	Membrane
DIR45_RS07910	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DIR45_RS07920	COG0456	acetyltransferase
DIR45_RS07970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DIR45_RS07995	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DIR45_RS08010	COG1215	transferase activity, transferring glycosyl groups
DIR45_RS08030	COG0454	-acetyltransferase
DIR45_RS08050	COG0328	RNA-DNA hybrid ribonuclease activity
DIR45_RS08090	COG1280	lysine exporter protein (LysE YggA)
DIR45_RS08105	COG3162	membrane
DIR45_RS08110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DIR45_RS08115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DIR45_RS08125	COG0475	glutathione-regulated potassium exporter activity
DIR45_RS08130	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DIR45_RS08135	COG4978	Transcriptional regulator
DIR45_RS08135	COG0789	Transcriptional regulator
DIR45_RS08145	COG2323	membrane
DIR45_RS08150	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DIR45_RS08205	COG1923	regulation of RNA biosynthetic process
DIR45_RS08215	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DIR45_RS08220	COG1360	Flagellar Motor Protein
DIR45_RS08225	COG2201	protein-glutamate methylesterase activity
DIR45_RS08235	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DIR45_RS08235	COG1776	CheC inhibitor of MCP methylation
DIR45_RS08250	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DIR45_RS08270	COG1256	bacterial-type flagellum assembly
DIR45_RS08295	COG1815	bacterial-type flagellum-dependent cell motility
DIR45_RS08300	COG1558	bacterial-type flagellum-dependent cell motility
DIR45_RS08315	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DIR45_RS08325	COG1157	protein secretion by the type III secretion system
DIR45_RS08365	COG0784	Response regulator, receiver
DIR45_RS08365	COG0835	chemotaxis
DIR45_RS08375	COG0463	Glycosyl transferase, family 2
DIR45_RS08400	COG0457	Tetratricopeptide repeat
DIR45_RS08400	COG0463	Glycosyl transferase, family 2
DIR45_RS08415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DIR45_RS08420	COG0741	lytic transglycosylase activity
DIR45_RS08435	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DIR45_RS08435	COG1776	CheC inhibitor of MCP methylation
DIR45_RS08445	COG1338	Plays a role in the flagellum-specific transport system
DIR45_RS08450	COG1987	bacterial-type flagellum assembly
DIR45_RS08460	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DIR45_RS08465	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DIR45_RS08470	COG1419	protein localization to endoplasmic reticulum
DIR45_RS08475	COG4786	Flagellar basal body rod
DIR45_RS08480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DIR45_RS08505	COG1309	transcriptional regulator
DIR45_RS08525	COG2329	Antibiotic biosynthesis monooxygenase
DIR45_RS08555	COG3842	ATPase activity
DIR45_RS08560	COG0725	ABC transporter, periplasmic molybdate-binding protein
DIR45_RS08570	COG1234	tRNA 3'-trailer cleavage
DIR45_RS08600	COG1686	Belongs to the peptidase S11 family
DIR45_RS08610	COG0406	alpha-ribazole phosphatase activity
DIR45_RS08640	COG0367	asparagine synthase
DIR45_RS08670	COG1802	Transcriptional regulator
DIR45_RS08675	COG0697	spore germination
DIR45_RS08680	COG0523	cobalamin synthesis protein
DIR45_RS08690	COG0701	Predicted permease
DIR45_RS08700	COG1216	Glycosyl transferase, family 2
DIR45_RS08700	COG0438	transferase activity, transferring glycosyl groups
DIR45_RS08705	COG1757	Na H antiporter
DIR45_RS08710	COG0114	fumarate hydratase activity
DIR45_RS08735	COG3340	Belongs to the peptidase S51 family
DIR45_RS08755	COG0785	Cytochrome C biogenesis protein
DIR45_RS08785	COG2733	membrane
DIR45_RS08825	COG1131	(ABC) transporter
DIR45_RS08840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DIR45_RS08845	COG0528	UMP kinase activity
DIR45_RS08855	COG1027	Aspartate ammonia-lyase
DIR45_RS08860	COG0281	malic enzyme
DIR45_RS08865	COG4191	Histidine kinase
DIR45_RS08870	COG0784	Response regulator, receiver
DIR45_RS08875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DIR45_RS08940	COG0860	N-Acetylmuramoyl-L-alanine amidase
DIR45_RS08950	COG2814	Major facilitator Superfamily
DIR45_RS08965	COG1966	Carbon starvation protein
DIR45_RS08975	COG0477	Major facilitator Superfamily
DIR45_RS08980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DIR45_RS08990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DIR45_RS09005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DIR45_RS09020	COG2244	polysaccharide biosynthetic process
DIR45_RS09025	COG0733	neurotransmitter:sodium symporter activity
DIR45_RS09035	COG5566	PFAM Mor transcription activator
DIR45_RS09040	COG2323	membrane
DIR45_RS09055	COG2084	Dehydrogenase
DIR45_RS09070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DIR45_RS09080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DIR45_RS09085	COG0028	Belongs to the TPP enzyme family
DIR45_RS09090	COG0440	acetolactate synthase activity
DIR45_RS09095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DIR45_RS09105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DIR45_RS09135	COG3384	dioxygenase
DIR45_RS09145	COG3279	Response regulator of the LytR AlgR family
DIR45_RS09150	COG0427	acetyl-CoA hydrolase
DIR45_RS09170	COG1073	alpha beta
DIR45_RS09175	COG4166	transmembrane transport
DIR45_RS09200	COG0535	radical SAM domain protein
DIR45_RS09205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_RS09225	COG1914	H( )-stimulated, divalent metal cation uptake system
DIR45_RS09240	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DIR45_RS09270	COG2390	Transcriptional regulator
DIR45_RS09280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DIR45_RS09285	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DIR45_RS09300	COG4224	UPF0291 protein
DIR45_RS09320	COG0006	proline dipeptidase activity
DIR45_RS09325	COG2132	Multicopper oxidase
DIR45_RS09340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DIR45_RS09355	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DIR45_RS09370	COG2372	response to copper ion
DIR45_RS09370	COG1276	copper resistance
DIR45_RS09375	COG4549	nuclear export factor GLE1
DIR45_RS09385	COG0697	spore germination
DIR45_RS09390	COG0583	DNA-binding transcription factor activity
DIR45_RS09395	COG1959	2 iron, 2 sulfur cluster binding
DIR45_RS09400	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DIR45_RS09405	COG0778	Nitroreductase
DIR45_RS09415	COG0628	permease
DIR45_RS09425	COG1231	oxidoreductase activity
DIR45_RS09430	COG0523	cobalamin synthesis protein
DIR45_RS09445	COG0318	PFAM AMP-dependent synthetase and ligase
DIR45_RS09450	COG2030	dehydratase
DIR45_RS09455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DIR45_RS09465	COG0411	ABC transporter
DIR45_RS09485	COG0583	DNA-binding transcription factor activity
DIR45_RS09495	COG1942	4-Oxalocrotonate Tautomerase
DIR45_RS09505	COG1846	Transcriptional regulator
DIR45_RS09515	COG1271	oxidase subunit
DIR45_RS09520	COG1294	oxidase, subunit
DIR45_RS09525	COG4988	ABC transporter
DIR45_RS09530	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DIR45_RS09550	COG1686	Belongs to the peptidase S11 family
DIR45_RS09565	COG1388	LysM domain
DIR45_RS09565	COG0791	NLP P60 protein
DIR45_RS09580	COG0745	RESPONSE REGULATOR receiver
DIR45_RS09595	COG0300	oxidoreductase activity
DIR45_RS09635	COG0460	homoserine dehydrogenase
DIR45_RS09660	COG1316	TRANSCRIPTIONal
DIR45_RS09670	COG0745	RESPONSE REGULATOR receiver
DIR45_RS09675	COG5002	protein histidine kinase activity
DIR45_RS09690	COG1285	pathogenesis
DIR45_RS09695	COG1247	-acetyltransferase
DIR45_RS09715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DIR45_RS09725	COG1082	Xylose isomerase domain protein TIM barrel
DIR45_RS09735	COG2814	Major facilitator Superfamily
DIR45_RS09740	COG1279	arginine transmembrane transporter activity
DIR45_RS09750	COG1752	Esterase of the alpha-beta hydrolase superfamily
DIR45_RS09785	COG0577	efflux transmembrane transporter activity
DIR45_RS09790	COG2002	toxin-antitoxin pair type II binding
DIR45_RS09795	COG1404	Belongs to the peptidase S8 family
DIR45_RS09800	COG0640	Transcriptional regulator
DIR45_RS09805	COG0667	Aldo Keto reductase
DIR45_RS09835	COG0840	transmembrane signaling receptor activity
DIR45_RS09850	COG3949	Membrane
DIR45_RS09855	COG0783	Belongs to the Dps family
DIR45_RS09870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DIR45_RS09880	COG1231	oxidoreductase activity
DIR45_RS09890	COG4989	oxidoreductase activity
DIR45_RS09895	COG0523	cobalamin synthesis protein
DIR45_RS09900	COG0456	acetyltransferase
DIR45_RS09970	COG0803	Belongs to the bacterial solute-binding protein 9 family
DIR45_RS09970	COG3443	Belongs to the bacterial solute-binding protein 9 family
DIR45_RS09975	COG0702	epimerase
DIR45_RS09985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DIR45_RS09995	COG4166	transmembrane transport
DIR45_RS10010	COG0406	alpha-ribazole phosphatase activity
DIR45_RS10020	COG5337	Spore coat protein CotH
DIR45_RS10025	COG1051	belongs to the nudix hydrolase family
DIR45_RS10030	COG0586	Pfam SNARE associated Golgi protein
DIR45_RS10035	COG2244	polysaccharide biosynthetic process
DIR45_RS10045	COG0701	Predicted permease
DIR45_RS10050	COG3689	TIGRFAM TIGR03943 family protein
DIR45_RS10055	COG1607	acyl-coa hydrolase
DIR45_RS10065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DIR45_RS10080	COG0702	epimerase
DIR45_RS10085	COG2839	Protein conserved in bacteria
DIR45_RS10090	COG1253	flavin adenine dinucleotide binding
DIR45_RS10105	COG1114	Component of the transport system for branched-chain amino acids
DIR45_RS10110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DIR45_RS10130	COG0860	N-Acetylmuramoyl-L-alanine amidase
DIR45_RS10140	COG1876	peptidase activity
DIR45_RS10150	COG0154	amidase activity
DIR45_RS10155	COG2211	Major facilitator Superfamily
DIR45_RS10175	COG0561	phosphatase activity
DIR45_RS10185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DIR45_RS10190	COG4106	trans-aconitate 2-methyltransferase activity
DIR45_RS10205	COG1819	glycosyl
DIR45_RS10210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_RS10215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIR45_RS10240	COG0456	acetyltransferase
DIR45_RS10295	COG3874	Sporulation protein YtfJ
DIR45_RS10320	COG2226	methyltransferase
DIR45_RS10345	COG0346	lactoylglutathione lyase activity
DIR45_RS10355	COG0604	alcohol dehydrogenase
DIR45_RS10360	COG1595	DNA-templated transcription, initiation
DIR45_RS10385	COG0386	Belongs to the glutathione peroxidase family
DIR45_RS10390	COG1305	Transglutaminase-like
DIR45_RS10395	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DIR45_RS10400	COG0714	Associated with various cellular activities
DIR45_RS10415	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DIR45_RS10420	COG1140	nitrate reductase beta subunit
DIR45_RS10425	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DIR45_RS10430	COG2181	nitrate reductase activity
DIR45_RS10450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DIR45_RS10455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DIR45_RS10460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DIR45_RS10465	COG0303	'Molybdopterin
DIR45_RS10470	COG0314	molybdopterin synthase activity
DIR45_RS10480	COG2223	nitrite transmembrane transporter activity
DIR45_RS10495	COG1648	precorrin-2 dehydrogenase activity
DIR45_RS10505	COG1587	Uroporphyrinogen-III synthase
DIR45_RS10505	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DIR45_RS10510	COG2146	nitrite reductase [NAD(P)H] activity
DIR45_RS10515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DIR45_RS10520	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DIR45_RS10555	COG2359	stage V sporulation protein S
DIR45_RS10570	COG5632	N-Acetylmuramoyl-L-alanine amidase
DIR45_RS10585	COG1418	mRNA catabolic process
DIR45_RS10590	COG0488	(ABC) transporter
DIR45_RS10605	COG0629	single-stranded DNA binding
DIR45_RS10620	COG1413	lyase activity
DIR45_RS10635	COG2521	methyltransferase
DIR45_RS10635	COG2136	Putative SAM-dependent methyltransferase
DIR45_RS10640	COG0018	arginyl-trna synthetase
DIR45_RS10665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DIR45_RS10680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DIR45_RS10685	COG0017	Asparaginyl-tRNA synthetase
DIR45_RS10795	COG1929	Belongs to the glycerate kinase type-1 family
DIR45_RS10800	COG0471	metal ion transport
DIR45_RS10805	COG0745	RESPONSE REGULATOR receiver
DIR45_RS10810	COG5002	protein histidine kinase activity
DIR45_RS10810	COG3850	Histidine kinase
DIR45_RS10825	COG0733	neurotransmitter:sodium symporter activity
DIR45_RS10850	COG2610	gluconate transmembrane transporter activity
DIR45_RS10855	COG1454	alcohol dehydrogenase
DIR45_RS10860	COG1794	racemase activity, acting on amino acids and derivatives
DIR45_RS10870	COG0456	acetyltransferase
DIR45_RS10885	COG1131	(ABC) transporter
DIR45_RS10900	COG0546	phosphoglycolate phosphatase activity
DIR45_RS10920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DIR45_RS10935	COG0768	penicillin binding
DIR45_RS10940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DIR45_RS10945	COG0204	Acyl-transferase
DIR45_RS10950	COG1272	protein, Hemolysin III
DIR45_RS10960	COG0805	protein transport
DIR45_RS10970	COG1307	EDD domain protein, DegV family
DIR45_RS10975	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DIR45_RS10980	COG1999	signal sequence binding
DIR45_RS10985	COG0071	Belongs to the small heat shock protein (HSP20) family
DIR45_RS10990	COG0367	asparagine synthase
DIR45_RS11005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DIR45_RS11010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DIR45_RS11035	COG1051	belongs to the nudix hydrolase family
DIR45_RS11045	COG0668	transmembrane transport
DIR45_RS11050	COG2203	Gaf domain
DIR45_RS11050	COG4585	Histidine kinase
DIR45_RS11055	COG2197	response regulator
DIR45_RS11065	COG1064	alcohol dehydrogenase
DIR45_RS11090	COG1070	Carbohydrate kinase
DIR45_RS11095	COG1070	Carbohydrate kinase
DIR45_RS11125	COG1125	glycine betaine transport
DIR45_RS11125	COG0517	IMP dehydrogenase activity
DIR45_RS11130	COG1174	glycine betaine transport
DIR45_RS11165	COG1253	flavin adenine dinucleotide binding
DIR45_RS11170	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_RS11175	COG5506	Protein of unknown function (DUF1694)
DIR45_RS11190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DIR45_RS11195	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DIR45_RS11200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DIR45_RS11205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DIR45_RS11210	COG0456	acetyltransferase
DIR45_RS11215	COG3829	transcription factor binding
DIR45_RS11225	COG1509	lysine 2,3-aminomutase activity
DIR45_RS11265	COG4326	sporulation control protein
DIR45_RS11270	COG0671	phosphoesterase, PA-phosphatase related
DIR45_RS11275	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DIR45_RS11280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DIR45_RS11310	COG1715	Restriction endonuclease
DIR45_RS11310	COG1787	Restriction endonuclease
DIR45_RS11415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DIR45_RS11455	COG4499	WXG100 protein secretion system (Wss), protein YukC
DIR45_RS11455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DIR45_RS11460	COG2814	Major facilitator Superfamily
DIR45_RS11465	COG4841	protein insertion into membrane
DIR45_RS11470	COG0372	Belongs to the citrate synthase family
DIR45_RS11475	COG2079	MmgE PrpD family protein
DIR45_RS11480	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DIR45_RS11485	COG1960	acyl-CoA dehydrogenase activity
DIR45_RS11490	COG2084	Dehydrogenase
DIR45_RS11500	COG1280	lysine exporter protein (LysE YggA)
DIR45_RS11505	COG1024	Enoyl-CoA hydratase
DIR45_RS11520	COG0420	3'-5' exonuclease activity
DIR45_RS11525	COG0419	ATPase involved in DNA repair
DIR45_RS11545	COG2223	nitrite transmembrane transporter activity
DIR45_RS11555	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_RS11560	COG1169	isochorismate synthase
DIR45_RS11565	COG1021	2,3-dihydroxybenzoate-AMP ligase
DIR45_RS11570	COG1535	isochorismatase
DIR45_RS11570	COG3433	isochorismatase activity
DIR45_RS11580	COG3251	PFAM MbtH domain protein
DIR45_RS11585	COG2814	Major facilitator Superfamily
DIR45_RS11600	COG0776	regulation of translation
DIR45_RS11610	COG2318	DinB family
DIR45_RS11635	COG2329	Antibiotic biosynthesis monooxygenase
DIR45_RS11640	COG1187	pseudouridine synthase activity
DIR45_RS11645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DIR45_RS11660	COG0596	Alpha beta hydrolase
DIR45_RS11665	COG2814	Major facilitator Superfamily
DIR45_RS11685	COG2226	methyltransferase
DIR45_RS11730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_RS11765	COG1247	-acetyltransferase
DIR45_RS11795	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DIR45_RS11805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_RS11815	COG1278	Cold shock
DIR45_RS11830	COG0010	Belongs to the arginase family
DIR45_RS11835	COG0561	phosphatase activity
DIR45_RS11880	COG0583	DNA-binding transcription factor activity
DIR45_RS11885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DIR45_RS11900	COG0583	DNA-binding transcription factor activity
DIR45_RS11905	COG2258	MOSC domain
DIR45_RS11920	COG1132	(ABC) transporter
DIR45_RS11925	COG1132	(ABC) transporter
DIR45_RS11945	COG1396	sequence-specific DNA binding
DIR45_RS11970	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
DIR45_RS11975	COG1595	DNA-templated transcription, initiation
DIR45_RS11995	COG1649	PFAM Uncharacterised BCR, COG1649
DIR45_RS12020	COG2971	BadF BadG BcrA BcrD
DIR45_RS12025	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DIR45_RS12030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DIR45_RS12055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_RS12085	COG1309	transcriptional regulator
DIR45_RS12100	COG0577	efflux transmembrane transporter activity
DIR45_RS12100	COG1136	(ABC) transporter
DIR45_RS12105	COG0500	methyltransferase
DIR45_RS12105	COG3615	Tellurite resistance protein tehB
DIR45_RS12115	COG2226	methyltransferase
DIR45_RS12120	COG3961	Belongs to the TPP enzyme family
DIR45_RS12125	COG1846	Transcriptional regulator
DIR45_RS12155	COG2195	Cleaves the N-terminal amino acid of tripeptides
DIR45_RS12170	COG1595	DNA-templated transcription, initiation
DIR45_RS12180	COG0768	penicillin binding
DIR45_RS12185	COG0768	penicillin binding
DIR45_RS12190	COG2367	Beta-lactamase
DIR45_RS12200	COG1609	Transcriptional regulator
DIR45_RS12210	COG0673	inositol 2-dehydrogenase activity
DIR45_RS12220	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_RS12235	COG0191	fructose-bisphosphate aldolase activity
DIR45_RS12255	COG0737	Belongs to the 5'-nucleotidase family
DIR45_RS12265	COG0457	Tetratricopeptide repeat
DIR45_RS12270	COG1476	TRANSCRIPTIONal
DIR45_RS12290	COG1876	peptidase activity
DIR45_RS12310	COG1309	transcriptional regulator
DIR45_RS12315	COG0488	(ABC) transporter
DIR45_RS12330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_RS12350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DIR45_RS12365	COG1131	(ABC) transporter
DIR45_RS12375	COG1309	transcriptional regulator
DIR45_RS12390	COG1960	acyl-CoA dehydrogenase activity
DIR45_RS12395	COG0439	Biotin carboxylase
DIR45_RS12400	COG0511	ligase activity, forming carbon-carbon bonds
DIR45_RS12405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DIR45_RS12410	COG1024	Enoyl-CoA hydratase
DIR45_RS12415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DIR45_RS12420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DIR45_RS12430	COG1247	-acetyltransferase
DIR45_RS12435	COG0572	uridine kinase
DIR45_RS12445	COG2318	DinB family
DIR45_RS12450	COG1686	Belongs to the peptidase S11 family
DIR45_RS12475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DIR45_RS12515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DIR45_RS12515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DIR45_RS12540	COG2814	Major facilitator Superfamily
DIR45_RS12555	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DIR45_RS12575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIR45_RS12590	COG1063	alcohol dehydrogenase
DIR45_RS12615	COG3773	Cell wall hydrolase
DIR45_RS12625	COG0745	RESPONSE REGULATOR receiver
DIR45_RS12640	COG0488	(ABC) transporter
DIR45_RS12655	COG1136	(ABC) transporter
DIR45_RS12680	COG0460	homoserine dehydrogenase
DIR45_RS12685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIR45_RS12695	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DIR45_RS12765	COG2124	cytochrome p450
DIR45_RS12800	COG0561	phosphatase activity
DIR45_RS12810	COG5002	protein histidine kinase activity
DIR45_RS12815	COG0768	penicillin binding
DIR45_RS12820	COG1819	glycosyl
DIR45_RS12825	COG1794	racemase activity, acting on amino acids and derivatives
DIR45_RS12835	COG1122	ATPase activity
DIR45_RS12850	COG2205	protein histidine kinase activity
DIR45_RS12860	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DIR45_RS12865	COG0604	alcohol dehydrogenase
DIR45_RS12870	COG0768	penicillin binding
DIR45_RS12880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DIR45_RS12915	COG0693	protein deglycase activity
DIR45_RS12945	COG2814	Major facilitator Superfamily
DIR45_RS12960	COG0584	glycerophosphoryl diester phosphodiesterase
DIR45_RS13005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DIR45_RS13010	COG2223	nitrite transmembrane transporter activity
DIR45_RS13025	COG2816	NAD+ diphosphatase activity
DIR45_RS13030	COG0592	DNA-directed DNA polymerase activity
DIR45_RS13035	COG1051	belongs to the nudix hydrolase family
DIR45_RS13070	COG3878	Protein conserved in bacteria
DIR45_RS13120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DIR45_RS13135	COG0322	excinuclease ABC activity
DIR45_RS13175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DIR45_RS13200	COG1011	Hydrolase
DIR45_RS13215	COG0657	acetylesterase activity
DIR45_RS13220	COG0076	glutamate decarboxylase activity
DIR45_RS13235	COG1523	belongs to the glycosyl hydrolase 13 family
DIR45_RS13240	COG3227	Zinc metalloprotease (Elastase)
DIR45_RS13260	COG0201	protein transport
DIR45_RS13270	COG0697	spore germination
DIR45_RS13275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIR45_RS13305	COG4129	membrane
DIR45_RS13310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_RS13325	COG2959	enzyme of heme biosynthesis
DIR45_RS13345	COG3483	tryptophan 2,3-dioxygenase activity
DIR45_RS13350	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DIR45_RS13355	COG3844	kynureninase activity
DIR45_RS13360	COG1309	transcriptional regulator
DIR45_RS13395	COG3284	Transcriptional regulator
DIR45_RS13410	COG1349	DNA-binding transcription factor activity
DIR45_RS13430	COG1959	2 iron, 2 sulfur cluster binding
DIR45_RS13445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DIR45_RS13450	COG0508	dehydrogenase complex catalyzes the overall conversion of
DIR45_RS13455	COG0022	dehydrogenase e1 component
DIR45_RS13460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DIR45_RS13470	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_RS13475	COG0456	acetyltransferase
DIR45_RS13475	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DIR45_RS13510	COG4176	ABC-type proline glycine betaine transport system permease component
DIR45_RS13515	COG0517	IMP dehydrogenase activity
DIR45_RS13515	COG4175	Glycine betaine
DIR45_RS13540	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DIR45_RS13545	COG2153	protein acetylation
DIR45_RS13550	COG3397	chitin binding
DIR45_RS13565	COG2205	protein histidine kinase activity
DIR45_RS13585	COG2333	competence protein COMEC
DIR45_RS13585	COG0658	competence protein
DIR45_RS13635	COG3973	AAA domain
DIR45_RS13650	COG2105	PFAM AIG2 family protein
DIR45_RS13655	COG0514	ATP-dependent DNA helicase (RecQ)
DIR45_RS13680	COG4637	Psort location Cytoplasmic, score
DIR45_RS13705	COG3397	chitin binding
DIR45_RS13720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DIR45_RS13725	COG1115	amino acid carrier protein
DIR45_RS13730	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_RS13735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DIR45_RS13745	COG3938	Belongs to the proline racemase family
DIR45_RS13750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DIR45_RS13790	COG0586	Pfam SNARE associated Golgi protein
DIR45_RS13805	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DIR45_RS13810	COG0519	Catalyzes the synthesis of GMP from XMP
DIR45_RS13815	COG4166	transmembrane transport
DIR45_RS13825	COG4948	Mandelate Racemase Muconate Lactonizing
DIR45_RS13870	COG2936	dipeptidyl-peptidase activity
DIR45_RS13875	COG5002	protein histidine kinase activity
DIR45_RS13880	COG0745	RESPONSE REGULATOR receiver
DIR45_RS13915	COG1164	Oligoendopeptidase f
DIR45_RS13930	COG1307	EDD domain protein, DegV family
DIR45_RS13950	COG2814	Major facilitator Superfamily
DIR45_RS13960	COG1664	Polymer-forming cytoskeletal
DIR45_RS13965	COG0789	Transcriptional regulator
DIR45_RS13970	COG4533	DNA binding
DIR45_RS13975	COG0477	Major facilitator Superfamily
DIR45_RS13975	COG2814	Major facilitator Superfamily
DIR45_RS13995	COG2261	transglycosylase associated protein
DIR45_RS14010	COG2226	methyltransferase
DIR45_RS14045	COG0436	Aminotransferase
DIR45_RS14050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DIR45_RS14055	COG5146	pantothenate kinase activity
DIR45_RS14075	COG1131	(ABC) transporter
DIR45_RS14115	COG0628	permease
DIR45_RS14125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DIR45_RS14130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DIR45_RS14135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DIR45_RS14140	COG1116	anion transmembrane transporter activity
DIR45_RS14160	COG2816	NAD+ diphosphatase activity
DIR45_RS14180	COG2746	aminoglycoside 3-N-acetyltransferase activity
DIR45_RS14205	COG0697	spore germination
DIR45_RS14210	COG2318	DinB family
DIR45_RS14230	COG4912	Dna alkylation repair
DIR45_RS14250	COG0861	Integral membrane protein TerC family
DIR45_RS14255	COG1368	sulfuric ester hydrolase activity
DIR45_RS14265	COG0488	(ABC) transporter
DIR45_RS14280	COG1309	transcriptional regulator
DIR45_RS14295	COG0287	Prephenate dehydrogenase
DIR45_RS14300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DIR45_RS14305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DIR45_RS14310	COG1605	Chorismate mutase
DIR45_RS14310	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DIR45_RS14350	COG3584	3D domain protein
DIR45_RS14350	COG1388	LysM domain
DIR45_RS14360	COG1595	DNA-templated transcription, initiation
DIR45_RS14385	COG1879	ABC-type sugar transport system periplasmic component
DIR45_RS14395	COG1172	Belongs to the binding-protein-dependent transport system permease family
DIR45_RS14405	COG2390	Transcriptional regulator
DIR45_RS14410	COG1070	Carbohydrate kinase
DIR45_RS14440	COG2329	Antibiotic biosynthesis monooxygenase
DIR45_RS14460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DIR45_RS14470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DIR45_RS14475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DIR45_RS14480	COG4187	Peptidase family M20/M25/M40
DIR45_RS14485	COG1414	Transcriptional regulator
DIR45_RS14495	COG0833	amino acid
DIR45_RS14500	COG1690	Belongs to the RtcB family
DIR45_RS14505	COG3239	Fatty acid desaturase
DIR45_RS14510	COG1785	Belongs to the alkaline phosphatase family
DIR45_RS14520	COG3655	Transcriptional regulator
DIR45_RS14535	COG4377	Putative membrane peptidase family (DUF2324)
DIR45_RS14545	COG3279	Response regulator of the LytR AlgR family
DIR45_RS14555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_RS14560	COG0346	lactoylglutathione lyase activity
DIR45_RS14580	COG0714	Associated with various cellular activities
DIR45_RS14605	COG0463	Glycosyl transferase, family 2
DIR45_RS14630	COG0463	Glycosyl transferase, family 2
DIR45_RS14640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DIR45_RS14645	COG0753	catalase activity
DIR45_RS14655	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DIR45_RS14680	COG0714	Associated with various cellular activities
DIR45_RS14690	COG0778	Nitroreductase
DIR45_RS14695	COG1846	Transcriptional regulator
DIR45_RS14735	COG1725	Transcriptional regulator
DIR45_RS14745	COG0577	efflux transmembrane transporter activity
DIR45_RS14745	COG1136	(ABC) transporter
DIR45_RS14770	COG2207	Transcriptional regulator
DIR45_RS14775	COG0456	acetyltransferase
DIR45_RS14795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIR45_RS14815	COG0642	Histidine kinase
DIR45_RS14820	COG0745	RESPONSE REGULATOR receiver
DIR45_RS14825	COG0596	Alpha beta hydrolase
DIR45_RS14855	COG0730	response to heat
DIR45_RS14865	COG0833	amino acid
DIR45_RS14875	COG4335	DNA alkylation repair
DIR45_RS14910	COG0768	penicillin binding
DIR45_RS14920	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DIR45_RS14955	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DIR45_RS14960	COG1414	Transcriptional regulator
DIR45_RS14975	COG0860	N-Acetylmuramoyl-L-alanine amidase
DIR45_RS14980	COG0640	Transcriptional regulator
DIR45_RS14990	COG1960	acyl-CoA dehydrogenase activity
DIR45_RS15005	COG3314	Sporulation integral membrane protein YlbJ
DIR45_RS15020	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DIR45_RS15035	COG0574	Belongs to the PEP-utilizing enzyme family
DIR45_RS15035	COG3848	Pyruvate phosphate dikinase
DIR45_RS15040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_RS15055	COG5577	PFAM Coat F domain
DIR45_RS15060	COG3403	YqcI/YcgG family
DIR45_RS15065	COG1280	lysine exporter protein (LysE YggA)
DIR45_RS15095	COG1063	alcohol dehydrogenase
DIR45_RS15110	COG1027	Aspartate ammonia-lyase
DIR45_RS15115	COG0252	asparaginase activity
DIR45_RS15120	COG1396	sequence-specific DNA binding
DIR45_RS15130	COG0322	excinuclease ABC activity
DIR45_RS15135	COG0531	amino acid
DIR45_RS15140	COG1114	Component of the transport system for branched-chain amino acids
DIR45_RS15145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DIR45_RS15155	COG0281	malic enzyme
DIR45_RS15170	COG0531	amino acid
DIR45_RS15180	COG0784	Response regulator, receiver
DIR45_RS15190	COG2066	Belongs to the glutaminase family
DIR45_RS15195	COG1115	amino acid carrier protein
DIR45_RS15225	COG0737	Belongs to the 5'-nucleotidase family
DIR45_RS15230	COG0753	catalase activity
DIR45_RS15235	COG2267	carboxylic ester hydrolase activity
DIR45_RS15240	COG1335	isochorismatase
DIR45_RS15260	COG0583	DNA-binding transcription factor activity
DIR45_RS15270	COG1846	Transcriptional regulator
DIR45_RS15275	COG0598	Magnesium transport protein CorA
DIR45_RS15315	COG0415	Belongs to the DNA photolyase family
DIR45_RS15320	COG0288	reversible hydration of carbon dioxide
DIR45_RS15330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DIR45_RS15335	COG5609	conserved protein (DUF2294)
DIR45_RS15350	COG1575	Belongs to the MenA family. Type 1 subfamily
DIR45_RS15355	COG2267	carboxylic ester hydrolase activity
DIR45_RS15360	COG0803	Belongs to the bacterial solute-binding protein 9 family
DIR45_RS15365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DIR45_RS15370	COG1121	(ABC) transporter
DIR45_RS15400	COG0798	PFAM Bile acid sodium symporter
DIR45_RS15405	COG0346	lactoylglutathione lyase activity
DIR45_RS15410	COG0640	Transcriptional regulator
DIR45_RS15425	COG0443	Heat shock 70 kDa protein
DIR45_RS15445	COG1522	sequence-specific DNA binding
DIR45_RS15465	COG0346	lactoylglutathione lyase activity
DIR45_RS15485	COG2169	Transcriptional regulator
DIR45_RS15525	COG2814	Major facilitator Superfamily
DIR45_RS15555	COG0745	RESPONSE REGULATOR receiver
DIR45_RS15560	COG5002	protein histidine kinase activity
DIR45_RS15560	COG3850	Histidine kinase
DIR45_RS15590	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DIR45_RS15620	COG1476	TRANSCRIPTIONal
DIR45_RS15635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_RS15640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DIR45_RS15650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DIR45_RS15655	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DIR45_RS15670	COG1136	(ABC) transporter
DIR45_RS15675	COG0577	efflux transmembrane transporter activity
DIR45_RS15690	COG5002	protein histidine kinase activity
DIR45_RS15690	COG3850	Histidine kinase
DIR45_RS15700	COG2364	Membrane
DIR45_RS15705	COG1846	Transcriptional regulator
DIR45_RS15715	COG2808	Putative FMN-binding domain
DIR45_RS15720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_RS15725	COG2271	Major facilitator Superfamily
DIR45_RS15730	COG1556	Lactate utilization protein
DIR45_RS15735	COG1139	Iron-sulfur cluster binding protein
DIR45_RS15745	COG0583	DNA-binding transcription factor activity
DIR45_RS15755	COG1619	proteins homologs of microcin C7 resistance protein MccF
DIR45_RS15790	COG0673	inositol 2-dehydrogenase activity
DIR45_RS15795	COG0561	phosphatase activity
DIR45_RS15805	COG1609	Transcriptional regulator
DIR45_RS15810	COG0457	Tetratricopeptide repeat
DIR45_RS15825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DIR45_RS15855	COG0534	Mate efflux family protein
DIR45_RS15875	COG2814	Major facilitator Superfamily
DIR45_RS15880	COG1309	transcriptional regulator
DIR45_RS15895	COG0814	amino acid
DIR45_RS15900	COG1760	l-serine dehydratase
DIR45_RS15915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DIR45_RS15920	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DIR45_RS15935	COG1522	sequence-specific DNA binding
DIR45_RS15940	COG0531	amino acid
DIR45_RS15960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DIR45_RS15980	COG1595	DNA-templated transcription, initiation
DIR45_RS15995	COG0662	Cupin 2, conserved barrel domain protein
DIR45_RS16005	COG2207	Transcriptional regulator
DIR45_RS16005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DIR45_RS16055	COG0477	Major facilitator Superfamily
DIR45_RS16065	COG1846	Transcriptional regulator
DIR45_RS16070	COG2814	Major facilitator Superfamily
DIR45_RS16080	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DIR45_RS16085	COG1131	(ABC) transporter
DIR45_RS16105	COG2076	Multidrug Resistance protein
DIR45_RS16110	COG1309	transcriptional regulator
DIR45_RS16120	COG2031	fatty acid transporter
DIR45_RS16130	COG2249	NAD(P)H dehydrogenase (quinone) activity
DIR45_RS16160	COG1122	ATPase activity
DIR45_RS16165	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DIR45_RS16180	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DIR45_RS16185	COG1288	antiporter activity
DIR45_RS16190	COG2356	endonuclease I
DIR45_RS16205	COG3620	sequence-specific DNA binding
DIR45_RS16210	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DIR45_RS16215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DIR45_RS16220	COG0124	histidyl-tRNA synthetase
DIR45_RS16235	COG1733	regulation of RNA biosynthetic process
DIR45_RS16240	COG0778	Nitroreductase
DIR45_RS16260	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_RS16270	COG1131	(ABC) transporter
DIR45_RS16295	COG1011	Hydrolase
DIR45_RS16305	COG2365	Tyrosine phosphatase family
DIR45_RS16330	COG0346	lactoylglutathione lyase activity
DIR45_RS16335	COG1940	carbohydrate kinase activity
DIR45_RS16340	COG0738	Major facilitator superfamily
DIR45_RS16345	COG0110	maltose O-acetyltransferase activity
DIR45_RS16355	COG1136	(ABC) transporter
DIR45_RS16355	COG0577	efflux transmembrane transporter activity
DIR45_RS16365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DIR45_RS16370	COG0628	permease
DIR45_RS16385	COG2226	methyltransferase
DIR45_RS16395	COG0477	Major facilitator Superfamily
DIR45_RS16425	COG1253	flavin adenine dinucleotide binding
DIR45_RS16430	COG0789	Transcriptional regulator
DIR45_RS16435	COG0697	spore germination
DIR45_RS16440	COG1357	PFAM Pentapeptide repeats (8 copies)
DIR45_RS16445	COG3813	Protein conserved in bacteria
DIR45_RS16455	COG2706	6-phosphogluconolactonase activity
DIR45_RS16460	COG1070	Carbohydrate kinase
DIR45_RS16470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DIR45_RS16475	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DIR45_RS16485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DIR45_RS16490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DIR45_RS16495	COG0604	alcohol dehydrogenase
DIR45_RS16500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DIR45_RS16510	COG0604	alcohol dehydrogenase
DIR45_RS16510	COG3321	synthase
DIR45_RS16520	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_RS16545	COG0656	L-ascorbic acid biosynthetic process
DIR45_RS16550	COG2814	Major facilitator Superfamily
DIR45_RS16565	COG0346	lactoylglutathione lyase activity
DIR45_RS16570	COG0814	amino acid
DIR45_RS16595	COG1393	Belongs to the ArsC family
DIR45_RS16600	COG1733	regulation of RNA biosynthetic process
DIR45_RS16605	COG2188	Transcriptional regulator
DIR45_RS16610	COG0673	inositol 2-dehydrogenase activity
DIR45_RS16615	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DIR45_RS16620	COG1733	regulation of RNA biosynthetic process
DIR45_RS16625	COG1733	regulation of RNA biosynthetic process
DIR45_RS16640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_RS16660	COG0384	phenazine biosynthesis protein PhzF
DIR45_RS16670	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_RS16680	COG0318	PFAM AMP-dependent synthetase and ligase
DIR45_RS16690	COG1733	regulation of RNA biosynthetic process
DIR45_RS16725	COG1191	sigma factor activity
DIR45_RS16740	COG1309	transcriptional regulator
DIR45_RS16760	COG3152	Membrane
DIR45_RS16785	COG1151	hydroxylamine reductase activity
DIR45_RS16795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_RS16800	COG3409	Peptidoglycan-binding domain 1 protein
DIR45_RS16800	COG3757	hydrolase, family 25
DIR45_RS16835	COG2072	flavoprotein involved in K transport
DIR45_RS16870	COG0604	alcohol dehydrogenase
DIR45_RS16875	COG1113	amino acid transport
DIR45_RS16880	COG2814	Major facilitator Superfamily
DIR45_RS16910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DIR45_RS16915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DIR45_RS16940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DIR45_RS16945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_RS16950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_RS16955	COG3739	integral membrane protein
DIR45_RS16960	COG0384	phenazine biosynthesis protein PhzF
DIR45_RS16990	COG0583	DNA-binding transcription factor activity
DIR45_RS17010	COG1193	negative regulation of DNA recombination
DIR45_RS17025	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DIR45_RS17030	COG1164	Oligoendopeptidase f
DIR45_RS17035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DIR45_RS17065	COG0584	glycerophosphoryl diester phosphodiesterase
DIR45_RS17090	COG0640	Transcriptional regulator
DIR45_RS17095	COG0604	alcohol dehydrogenase
DIR45_RS17115	COG2808	Putative FMN-binding domain
DIR45_RS17130	COG0385	Bile acid
DIR45_RS17135	COG0277	FAD linked oxidase domain protein
DIR45_RS17170	COG1216	Glycosyl transferase, family 2
DIR45_RS17175	COG1024	Enoyl-CoA hydratase
DIR45_RS17185	COG1285	pathogenesis
DIR45_RS17200	COG2514	catechol 2,3-dioxygenase activity
DIR45_RS17205	COG2720	vancomycin resistance protein
DIR45_RS17240	COG0716	FMN binding
DIR45_RS17270	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_RS17295	COG4145	pantothenate transmembrane transporter activity
DIR45_RS17305	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_RS17310	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_RS17320	COG1657	PFAM Prenyltransferase squalene oxidase
DIR45_RS17325	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DIR45_RS17330	COG2962	Rard protein
DIR45_RS17335	COG3326	Membrane
DIR45_RS17350	COG0489	protein tyrosine kinase activity
DIR45_RS17360	COG0314	molybdopterin synthase activity
DIR45_RS17365	COG0303	'Molybdopterin
DIR45_RS17370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DIR45_RS17375	COG2116	formate transmembrane transporter activity
DIR45_RS17385	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DIR45_RS17390	COG5609	conserved protein (DUF2294)
DIR45_RS17395	COG2427	Protein of unknown function (DUF1641)
DIR45_RS17400	COG3383	formate dehydrogenase (NAD+) activity
DIR45_RS17405	COG0697	spore germination
DIR45_RS17445	COG2226	methyltransferase
DIR45_RS17450	COG4166	transmembrane transport
DIR45_RS17455	COG4166	transmembrane transport
DIR45_RS17460	COG1301	dicarboxylic acid transport
DIR45_RS17465	COG1316	TRANSCRIPTIONal
DIR45_RS17475	COG1595	DNA-templated transcription, initiation
DIR45_RS17490	COG1131	(ABC) transporter
DIR45_RS17500	COG0673	inositol 2-dehydrogenase activity
DIR45_RS17505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DIR45_RS17510	COG0187	DNA topoisomerase II activity
DIR45_RS17515	COG1832	CoA-binding protein
DIR45_RS17520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DIR45_RS17525	COG0745	RESPONSE REGULATOR receiver
DIR45_RS17540	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DIR45_RS17545	COG4841	protein insertion into membrane
DIR45_RS17550	COG0824	Thioesterase
DIR45_RS17580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DIR45_RS17590	COG2274	protein secretion by the type I secretion system
DIR45_RS17595	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DIR45_RS17635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DIR45_RS17650	COG0183	Belongs to the thiolase family
DIR45_RS17655	COG0318	PFAM AMP-dependent synthetase and ligase
DIR45_RS17660	COG1268	BioY protein
DIR45_RS17665	COG0318	PFAM AMP-dependent synthetase and ligase
DIR45_RS17715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_RS17730	COG5002	protein histidine kinase activity
DIR45_RS17735	COG0400	carboxylic ester hydrolase activity
DIR45_RS17740	COG0346	lactoylglutathione lyase activity
DIR45_RS17745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DIR45_RS17750	COG0069	glutamate synthase activity
DIR45_RS17755	COG1902	pentaerythritol trinitrate reductase activity
DIR45_RS17760	COG1329	Transcriptional regulator
DIR45_RS17765	COG0010	Belongs to the arginase family
DIR45_RS17790	COG2226	methyltransferase
DIR45_RS17850	COG4846	Membrane protein involved in cytochrome C biogenesis
DIR45_RS17855	COG0785	Cytochrome C biogenesis protein
DIR45_RS17870	COG0583	DNA-binding transcription factor activity
DIR45_RS17875	COG1380	Effector of murein hydrolase LrgA
DIR45_RS17880	COG1346	cytolysis
DIR45_RS17905	COG3409	Peptidoglycan-binding domain 1 protein
DIR45_RS17905	COG5632	N-Acetylmuramoyl-L-alanine amidase
DIR45_RS17920	COG1132	(ABC) transporter
DIR45_RS17925	COG1132	(ABC) transporter
DIR45_RS17965	COG3639	organic phosphonate transmembrane transporter activity
DIR45_RS17970	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DIR45_RS17990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DIR45_RS18010	COG1695	Transcriptional regulator
DIR45_RS18045	COG1388	LysM domain
DIR45_RS18045	COG5632	N-Acetylmuramoyl-L-alanine amidase
DIR45_RS18045	COG3409	Peptidoglycan-binding domain 1 protein
DIR45_RS18050	COG4824	toxin secretion phage lysis holin
DIR45_RS18195	COG1595	DNA-templated transcription, initiation
DIR45_RS18235	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DIR45_RS18320	COG1396	sequence-specific DNA binding
DIR45_RS18340	COG0174	glutamine synthetase
DIR45_RS18345	COG0789	Transcriptional regulator
DIR45_RS18350	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DIR45_RS18355	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DIR45_RS18360	COG2860	membrane
DIR45_RS18365	COG0464	growth
DIR45_RS18395	COG1388	LysM domain
DIR45_RS18395	COG3584	3D domain protein
DIR45_RS18400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DIR45_RS18400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DIR45_RS18400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DIR45_RS18405	COG1105	Belongs to the carbohydrate kinase PfkB family
DIR45_RS18410	COG1349	DNA-binding transcription factor activity
DIR45_RS18420	COG2322	membrane
DIR45_RS18430	COG1113	amino acid transport
DIR45_RS18450	COG1408	metallophosphoesterase
DIR45_RS18455	COG2116	formate transmembrane transporter activity
DIR45_RS18465	COG2217	Heavy metal translocating P-type atpase
DIR45_RS18470	COG2608	mercury ion transmembrane transporter activity
DIR45_RS18475	COG1937	Protein conserved in bacteria
DIR45_RS18485	COG2819	hydrolase of the alpha beta superfamily
DIR45_RS18490	COG1120	ATPase activity
DIR45_RS18495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_RS18500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_RS18515	COG2169	Transcriptional regulator
DIR45_RS18520	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DIR45_RS18525	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DIR45_RS18535	COG2364	Membrane
DIR45_RS18555	COG0346	lactoylglutathione lyase activity
DIR45_RS18560	COG5001	Diguanylate cyclase
DIR45_RS18560	COG3300	MHYT domain
DIR45_RS18580	COG1346	cytolysis
DIR45_RS18585	COG1380	Effector of murein hydrolase LrgA
DIR45_RS18590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIR45_RS18595	COG0596	Alpha beta hydrolase
DIR45_RS18595	COG0508	dehydrogenase complex catalyzes the overall conversion of
DIR45_RS18600	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DIR45_RS18620	COG1404	Belongs to the peptidase S8 family
DIR45_RS18625	COG3773	Cell wall hydrolase
DIR45_RS18630	COG0562	UDP-galactopyranose mutase
DIR45_RS18635	COG1368	sulfuric ester hydrolase activity
DIR45_RS18640	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DIR45_RS18650	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DIR45_RS18675	COG1131	(ABC) transporter
DIR45_RS18695	COG4550	Control of competence regulator ComK, YlbF/YmcA
DIR45_RS18700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DIR45_RS18705	COG1013	pyruvate-flavodoxin oxidoreductase activity
DIR45_RS18710	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DIR45_RS18710	COG0674	pyruvate-flavodoxin oxidoreductase activity
DIR45_RS18720	COG2359	stage V sporulation protein S
DIR45_RS18725	COG1692	metallophosphoesterase
DIR45_RS18750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DIR45_RS18755	COG1426	Protein conserved in bacteria
DIR45_RS18770	COG0300	oxidoreductase activity
DIR45_RS18775	COG0612	Peptidase, M16
DIR45_RS18780	COG0612	Peptidase, M16
DIR45_RS18785	COG1079	Belongs to the binding-protein-dependent transport system permease family
DIR45_RS18795	COG3845	ABC transporter
DIR45_RS18800	COG1744	ABC transporter substrate-binding protein PnrA-like
DIR45_RS18805	COG2188	Transcriptional regulator
DIR45_RS18810	COG1674	ftsk spoiiie
DIR45_RS18820	COG0740	serine-type endopeptidase activity
DIR45_RS18825	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DIR45_RS18840	COG0527	aspartate kinase activity
DIR45_RS18845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DIR45_RS18850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DIR45_RS18855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DIR45_RS18860	COG1873	PFAM PRC-barrel domain
DIR45_RS18865	COG0612	Peptidase, M16
DIR45_RS18870	COG0726	polysaccharide deacetylase
DIR45_RS18885	COG0196	riboflavin kinase activity
DIR45_RS18890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DIR45_RS18900	COG1550	Protein conserved in bacteria
DIR45_RS18910	COG1358	cellular component organization or biogenesis
DIR45_RS18915	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DIR45_RS18920	COG0195	Participates in both transcription termination and antitermination
DIR45_RS18940	COG0750	zinc metalloprotease
DIR45_RS18950	COG4589	Belongs to the CDS family
DIR45_RS18965	COG0528	UMP kinase activity
DIR45_RS18995	COG4974	Belongs to the 'phage' integrase family
DIR45_RS19005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DIR45_RS19015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DIR45_RS19055	COG1837	Belongs to the UPF0109 family
DIR45_RS19065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DIR45_RS19075	COG0552	protein localization to endoplasmic reticulum
DIR45_RS19080	COG1196	nuclear chromosome segregation
DIR45_RS19090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DIR45_RS19095	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_RS19100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DIR45_RS19115	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DIR45_RS19120	COG1461	Dihydroxyacetone kinase
DIR45_RS19125	COG1302	Protein conserved in bacteria
DIR45_RS19140	COG1564	THIamine pyrophosphokinase
DIR45_RS19145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DIR45_RS19150	COG1162	GTPase activity
DIR45_RS19155	COG2815	serine threonine protein kinase
DIR45_RS19155	COG0515	serine threonine protein kinase
DIR45_RS19160	COG0631	protein serine/threonine phosphatase activity
DIR45_RS19170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DIR45_RS19170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DIR45_RS19180	COG0242	peptide deformylase activity
DIR45_RS19185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DIR45_RS19190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DIR45_RS19210	COG1561	YicC-like family, N-terminal region
DIR45_RS19215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DIR45_RS19225	COG0006	proline dipeptidase activity
DIR45_RS19240	COG3069	C4-dicarboxylate transmembrane transporter activity
DIR45_RS19305	COG0564	pseudouridine synthase activity
DIR45_RS19325	COG3599	regulation of cell shape
DIR45_RS19330	COG2302	S4 RNA-binding domain
DIR45_RS19335	COG0762	integral membrane protein
DIR45_RS19345	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DIR45_RS19350	COG1496	oxidoreductase activity
DIR45_RS19355	COG1873	PFAM PRC-barrel domain
DIR45_RS19360	COG1191	sigma factor activity
DIR45_RS19365	COG1191	sigma factor activity
DIR45_RS19375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DIR45_RS19380	COG0849	cell division
DIR45_RS19385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DIR45_RS19390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DIR45_RS19400	COG0772	Belongs to the SEDS family
DIR45_RS19415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DIR45_RS19420	COG0768	penicillin binding
DIR45_RS19425	COG0768	penicillin binding
DIR45_RS19430	COG4839	cell division protein FtsL
DIR45_RS19445	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DIR45_RS19460	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DIR45_RS19465	COG1399	metal-binding, possibly nucleic acid-binding protein
DIR45_RS19515	COG4824	toxin secretion phage lysis holin
DIR45_RS19605	COG4626	Terminase
DIR45_RS19605	COG1802	Transcriptional regulator
DIR45_RS19630	COG0582	viral genome integration into host DNA
DIR45_RS19700	COG0756	dUTP diphosphatase activity
DIR45_RS19715	COG1191	sigma factor activity
DIR45_RS19740	COG1484	DNA-dependent DNA replication
DIR45_RS19760	COG1396	sequence-specific DNA binding
DIR45_RS19770	COG1396	sequence-specific DNA binding
DIR45_RS19780	COG0582	viral genome integration into host DNA
DIR45_RS19790	COG3480	Lon protease (S16) C-terminal proteolytic domain
DIR45_RS19795	COG1752	Esterase of the alpha-beta hydrolase superfamily
DIR45_RS19800	COG3314	Sporulation integral membrane protein YlbJ
DIR45_RS19810	COG0742	ribosomal rna small subunit methyltransferase
DIR45_RS19825	COG3679	Belongs to the UPF0342 family
DIR45_RS19830	COG0406	alpha-ribazole phosphatase activity
DIR45_RS19845	COG2340	Cysteine-rich secretory protein family
DIR45_RS19860	COG3336	cytochrome c oxidase
DIR45_RS19895	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DIR45_RS19905	COG0772	Belongs to the SEDS family
DIR45_RS19915	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DIR45_RS19920	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DIR45_RS19930	COG4896	Protein conserved in bacteria
DIR45_RS19945	COG1217	gtp-binding protein TYPA
DIR45_RS19955	COG0483	inositol monophosphate 1-phosphatase activity
DIR45_RS19975	COG1982	Orn Lys Arg decarboxylase major
DIR45_RS20025	COG0022	dehydrogenase e1 component
DIR45_RS20030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DIR45_RS20040	COG0242	peptide deformylase activity
DIR45_RS20060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DIR45_RS20065	COG0569	domain protein
DIR45_RS20085	COG0583	DNA-binding transcription factor activity
DIR45_RS20090	COG0517	IMP dehydrogenase activity
DIR45_RS20100	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DIR45_RS20105	COG4703	Protein of unknown function (DUF1797)
DIR45_RS20120	COG2200	EAL domain
DIR45_RS20125	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_RS20130	COG1408	metallophosphoesterase
DIR45_RS20180	COG2814	Major facilitator Superfamily
DIR45_RS20200	COG3209	COG3209 Rhs family protein
DIR45_RS20210	COG2205	protein histidine kinase activity
DIR45_RS20220	COG0436	Aminotransferase
DIR45_RS20225	COG1609	Transcriptional regulator
DIR45_RS20230	COG3833	ABC-type maltose transport systems, permease component
DIR45_RS20235	COG1175	transmembrane transport
DIR45_RS20240	COG2182	Extracellular solute-binding protein
DIR45_RS20250	COG0366	Alpha amylase catalytic
DIR45_RS20255	COG3842	ATPase activity
DIR45_RS20295	COG0183	Belongs to the thiolase family
DIR45_RS20335	COG1695	Transcriptional regulator
DIR45_RS20340	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_RS20350	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DIR45_RS20360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DIR45_RS20365	COG0436	Aminotransferase
DIR45_RS20385	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DIR45_RS20405	COG2199	diguanylate cyclase activity
DIR45_RS20410	COG0778	Nitroreductase
DIR45_RS20435	COG2190	(PTS) system
DIR45_RS20435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DIR45_RS20435	COG1263	PTS System
DIR45_RS20440	COG3711	transcriptional antiterminator
DIR45_RS20450	COG2188	Transcriptional regulator
DIR45_RS20460	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DIR45_RS20490	COG1547	Domain of unknown function (DUF309)
DIR45_RS20495	COG0456	acetyltransferase
DIR45_RS20505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DIR45_RS20510	COG4086	secreted protein
DIR45_RS20515	COG0561	phosphatase activity
DIR45_RS20520	COG0697	spore germination
DIR45_RS20535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DIR45_RS20560	COG0733	neurotransmitter:sodium symporter activity
DIR45_RS20580	COG1686	Belongs to the peptidase S11 family
DIR45_RS20590	COG1725	Transcriptional regulator
DIR45_RS20595	COG1131	(ABC) transporter
DIR45_RS20610	COG1846	Transcriptional regulator
DIR45_RS20625	COG0598	Magnesium transport protein CorA
DIR45_RS20650	COG4974	Belongs to the 'phage' integrase family
DIR45_RS20660	COG0735	belongs to the Fur family
DIR45_RS20665	COG1300	Membrane
DIR45_RS20685	COG0667	Aldo Keto reductase
DIR45_RS20690	COG0656	L-ascorbic acid biosynthetic process
DIR45_RS20695	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DIR45_RS20695	COG0456	acetyltransferase
DIR45_RS20705	COG4085	toxin activity
DIR45_RS20705	COG1525	nuclease
DIR45_RS20705	COG0737	Belongs to the 5'-nucleotidase family
DIR45_RS20715	COG0596	Alpha beta hydrolase
DIR45_RS20720	COG2056	Na+-H+ antiporter family
DIR45_RS20730	COG0456	acetyltransferase
DIR45_RS20735	COG1073	alpha beta
DIR45_RS20750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DIR45_RS20750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DIR45_RS20755	COG0307	riboflavin synthase, alpha
DIR45_RS20780	COG4106	trans-aconitate 2-methyltransferase activity
DIR45_RS20785	COG2226	methyltransferase
DIR45_RS20785	COG1073	alpha beta
DIR45_RS20800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DIR45_RS20810	COG1757	Na H antiporter
DIR45_RS20815	COG0737	Belongs to the 5'-nucleotidase family
DIR45_RS20825	COG1522	sequence-specific DNA binding
DIR45_RS20845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DIR45_RS20855	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DIR45_RS20870	COG0300	oxidoreductase activity
DIR45_RS20875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_RS20880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DIR45_RS20885	COG1760	l-serine dehydratase
DIR45_RS20890	COG1760	l-serine dehydratase
DIR45_RS20915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DIR45_RS20925	COG2195	Cleaves the N-terminal amino acid of tripeptides
DIR45_RS20930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_RS20940	COG1376	ErfK ybiS ycfS ynhG family protein
DIR45_RS20945	COG4129	membrane
DIR45_RS20950	COG1126	abc transporter atp-binding protein
DIR45_RS20955	COG0765	amino acid transport
DIR45_RS20960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DIR45_RS20975	COG2816	NAD+ diphosphatase activity
DIR45_RS20980	COG0772	Belongs to the SEDS family
DIR45_RS20990	COG0508	dehydrogenase complex catalyzes the overall conversion of
DIR45_RS20995	COG0022	dehydrogenase e1 component
DIR45_RS21000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DIR45_RS21005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DIR45_RS21020	COG0280	phosphate acetyltransferase
DIR45_RS21030	COG3290	protein histidine kinase activity
DIR45_RS21030	COG3829	transcription factor binding
DIR45_RS21040	COG0584	glycerophosphoryl diester phosphodiesterase
DIR45_RS21045	COG3093	addiction module antidote protein HigA
DIR45_RS21055	COG0745	RESPONSE REGULATOR receiver
DIR45_RS21065	COG0750	zinc metalloprotease
DIR45_RS21070	COG0497	DNA recombination
DIR45_RS21080	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DIR45_RS21090	COG0142	geranyltranstransferase activity
DIR45_RS21115	COG1302	Protein conserved in bacteria
DIR45_RS21120	COG0439	Biotin carboxylase
DIR45_RS21125	COG0511	ligase activity, forming carbon-carbon bonds
DIR45_RS21170	COG3854	ATPases associated with a variety of cellular activities
DIR45_RS21195	COG0006	proline dipeptidase activity
DIR45_RS21210	COG3872	metal-dependent enzyme
DIR45_RS21220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DIR45_RS21240	COG0095	Lipoate-protein ligase
DIR45_RS21245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DIR45_RS21250	COG1609	Transcriptional regulator
DIR45_RS21260	COG2076	Multidrug Resistance protein
DIR45_RS21265	COG2076	Multidrug Resistance protein
DIR45_RS21300	COG1131	(ABC) transporter
DIR45_RS21305	COG1725	Transcriptional regulator
DIR45_RS21340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DIR45_RS21395	COG4970	Tfp pilus assembly protein FimT
DIR45_RS21405	COG1459	type II secretion system
DIR45_RS21410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DIR45_RS21460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DIR45_RS21470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DIR45_RS21470	COG0646	methionine synthase
DIR45_RS21475	COG0626	cystathionine gamma-synthase activity
DIR45_RS21480	COG0626	cystathionine gamma-synthase activity
DIR45_RS21500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_RS21510	COG1940	carbohydrate kinase activity
DIR45_RS21515	COG4483	Protein conserved in bacteria
DIR45_RS21520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DIR45_RS21525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DIR45_RS21530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DIR45_RS21535	COG0704	Plays a role in the regulation of phosphate uptake
DIR45_RS21545	COG0581	inorganic phosphate transmembrane transporter activity
DIR45_RS21550	COG0573	inorganic phosphate transmembrane transporter activity
DIR45_RS21555	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DIR45_RS21560	COG0768	penicillin binding
DIR45_RS21565	COG0477	Major facilitator Superfamily
DIR45_RS21570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DIR45_RS21595	COG0735	belongs to the Fur family
DIR45_RS21600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DIR45_RS21605	COG1121	(ABC) transporter
DIR45_RS21610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_RS21640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DIR45_RS21645	COG2384	SAM-dependent methyltransferase
DIR45_RS21650	COG2010	Cytochrome c
DIR45_RS21655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DIR45_RS21660	COG0358	DNA primase activity
DIR45_RS21670	COG0517	IMP dehydrogenase activity
DIR45_RS21685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DIR45_RS21690	COG0295	cytidine deaminase activity
DIR45_RS21695	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DIR45_RS21705	COG1480	7TM receptor with intracellular HD hydrolase
DIR45_RS21710	COG1702	phosphate starvation-inducible protein PhoH
DIR45_RS21725	COG1610	YqeY-like protein
DIR45_RS21730	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DIR45_RS21740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DIR45_RS21745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DIR45_RS21775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DIR45_RS21780	COG1733	regulation of RNA biosynthetic process
DIR45_RS21805	COG1466	dna polymerase III delta subunit
DIR45_RS21815	COG2333	competence protein COMEC
DIR45_RS21815	COG0658	competence protein
DIR45_RS21820	COG2131	deaminase
DIR45_RS21825	COG1596	polysaccharide export
DIR45_RS21825	COG1555	photosystem II stabilization
DIR45_RS21830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DIR45_RS21835	COG2226	methyltransferase
DIR45_RS21840	COG0799	negative regulation of ribosome biogenesis
DIR45_RS21845	COG1713	HD superfamily hydrolase involved in NAD metabolism
DIR45_RS21855	COG1534	Rna-binding protein
DIR45_RS21865	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DIR45_RS21870	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DIR45_RS21895	COG1595	DNA-templated transcription, initiation
DIR45_RS21905	COG0778	Nitroreductase
DIR45_RS21910	COG2357	RelA SpoT domain protein
DIR45_RS21920	COG1785	Belongs to the alkaline phosphatase family
DIR45_RS21930	COG2267	carboxylic ester hydrolase activity
DIR45_RS21965	COG1404	Belongs to the peptidase S8 family
DIR45_RS21970	COG3186	Phenylalanine-4-hydroxylase
DIR45_RS21980	COG2514	catechol 2,3-dioxygenase activity
DIR45_RS21985	COG2259	Doxx family
DIR45_RS22025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DIR45_RS22035	COG1454	alcohol dehydrogenase
DIR45_RS22035	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_RS22040	COG0626	cystathionine gamma-synthase activity
DIR45_RS22045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DIR45_RS22070	COG0768	penicillin binding
DIR45_RS22085	COG0826	peptidase U32
DIR45_RS22090	COG0826	peptidase U32
DIR45_RS22095	COG4122	O-methyltransferase activity
DIR45_RS22100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DIR45_RS22120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DIR45_RS22130	COG0628	permease
DIR45_RS22150	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DIR45_RS22160	COG0482	sulfurtransferase activity
DIR45_RS22165	COG1104	cysteine desulfurase activity
DIR45_RS22170	COG1959	2 iron, 2 sulfur cluster binding
DIR45_RS22175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DIR45_RS22190	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DIR45_RS22210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DIR45_RS22220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DIR45_RS22220	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DIR45_RS22230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DIR45_RS22230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DIR45_RS22240	COG2244	polysaccharide biosynthetic process
DIR45_RS22245	COG2323	membrane
DIR45_RS22255	COG1862	Preprotein translocase
DIR45_RS22285	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DIR45_RS22295	COG0697	spore germination
DIR45_RS22300	COG0697	spore germination
DIR45_RS22305	COG0640	Transcriptional regulator
DIR45_RS22330	COG0157	Belongs to the NadC ModD family
DIR45_RS22335	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DIR45_RS22340	COG1104	cysteine desulfurase activity
DIR45_RS22345	COG1827	regulation of RNA biosynthetic process
DIR45_RS22350	COG2258	MOSC domain
DIR45_RS22355	COG0077	Prephenate dehydratase
DIR45_RS22360	COG0577	efflux transmembrane transporter activity
DIR45_RS22365	COG0577	efflux transmembrane transporter activity
DIR45_RS22370	COG1136	(ABC) transporter
DIR45_RS22380	COG0745	RESPONSE REGULATOR receiver
DIR45_RS22385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DIR45_RS22390	COG3290	protein histidine kinase activity
DIR45_RS22400	COG2868	ribosomal protein
DIR45_RS22410	COG1530	ribonuclease E activity
DIR45_RS22415	COG1994	Peptidase M50
DIR45_RS22420	COG0739	heme binding
DIR45_RS22425	COG2894	cell division
DIR45_RS22445	COG1077	Cell shape determining protein MreB Mrl
DIR45_RS22470	COG0285	dihydrofolate synthase activity
DIR45_RS22475	COG0525	valine-tRNA ligase activity
DIR45_RS22485	COG1388	LysM domain
DIR45_RS22495	COG0113	porphobilinogen synthase activity
DIR45_RS22500	COG1587	Uroporphyrinogen-III synthase
DIR45_RS22510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DIR45_RS22520	COG1846	Transcriptional regulator
DIR45_RS22525	COG1764	response to oxidative stress
DIR45_RS22540	COG0470	DNA polymerase III
DIR45_RS22540	COG1067	ATP-dependent peptidase activity
DIR45_RS22585	COG0622	Phosphoesterase
DIR45_RS22600	COG5401	PFAM Sporulation and spore germination
DIR45_RS22620	COG1309	transcriptional regulator
DIR45_RS22635	COG2197	response regulator
DIR45_RS22640	COG2233	PERMEase
DIR45_RS22650	COG0402	S-adenosylhomocysteine deaminase activity
DIR45_RS22655	COG0402	S-adenosylhomocysteine deaminase activity
DIR45_RS22665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DIR45_RS22675	COG0444	Belongs to the ABC transporter superfamily
DIR45_RS22680	COG4608	Belongs to the ABC transporter superfamily
DIR45_RS22690	COG3279	Response regulator of the LytR AlgR family
DIR45_RS22705	COG1983	PspC domain protein
DIR45_RS22710	COG1396	sequence-specific DNA binding
DIR45_RS22715	COG0697	spore germination
DIR45_RS22725	COG1959	2 iron, 2 sulfur cluster binding
DIR45_RS22730	COG1668	transmembrane transport
DIR45_RS22735	COG4152	abc transporter atp-binding protein
DIR45_RS22740	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DIR45_RS22750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DIR45_RS22755	COG1876	peptidase activity
DIR45_RS22760	COG0824	Thioesterase
DIR45_RS22765	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DIR45_RS22770	COG1053	succinate dehydrogenase
DIR45_RS22775	COG2009	succinate dehydrogenase
DIR45_RS22780	COG1719	4-vinyl reductase, 4VR
DIR45_RS22790	COG3118	belongs to the thioredoxin family
DIR45_RS22795	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DIR45_RS22800	COG2086	electron transfer activity
DIR45_RS22805	COG1024	Enoyl-CoA hydratase
DIR45_RS22810	COG1309	transcriptional regulator
DIR45_RS22815	COG0318	PFAM AMP-dependent synthetase and ligase
DIR45_RS22835	COG2318	DinB family
DIR45_RS22860	COG1131	(ABC) transporter
DIR45_RS22865	COG2205	protein histidine kinase activity
DIR45_RS22870	COG0745	RESPONSE REGULATOR receiver
DIR45_RS22875	COG4895	conserved protein (DUF2196)
DIR45_RS22880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DIR45_RS22895	COG4509	Sortase family
DIR45_RS22900	COG1120	ATPase activity
DIR45_RS22915	COG5386	Cell surface protein
DIR45_RS22925	COG5386	Cell surface protein
DIR45_RS22930	COG1114	Component of the transport system for branched-chain amino acids
DIR45_RS22935	COG1187	pseudouridine synthase activity
DIR45_RS22945	COG1796	DNA polymerase
DIR45_RS22945	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DIR45_RS22950	COG1286	toxin biosynthetic process
DIR45_RS22995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DIR45_RS23005	COG1418	mRNA catabolic process
DIR45_RS23030	COG2814	Major facilitator Superfamily
DIR45_RS23035	COG1566	PFAM secretion protein HlyD family protein
DIR45_RS23040	COG1309	transcriptional regulator
DIR45_RS23045	COG1363	Peptidase, m42
DIR45_RS23070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DIR45_RS23080	COG1484	DNA-dependent DNA replication
DIR45_RS23085	COG3611	Membrane attachment protein
DIR45_RS23095	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DIR45_RS23100	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DIR45_RS23105	COG0237	dephospho-CoA kinase activity
DIR45_RS23110	COG1971	Probably functions as a manganese efflux pump
DIR45_RS23120	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DIR45_RS23120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DIR45_RS23125	COG5002	protein histidine kinase activity
DIR45_RS23130	COG0745	RESPONSE REGULATOR receiver
DIR45_RS23145	COG0538	isocitrate dehydrogenase activity
DIR45_RS23150	COG0372	Belongs to the citrate synthase family
DIR45_RS23165	COG0628	permease
DIR45_RS23170	COG3030	protein affecting phage T7 exclusion by the F plasmid
DIR45_RS23195	COG1725	Transcriptional regulator
DIR45_RS23200	COG0281	malic enzyme
DIR45_RS23205	COG0587	DNA-directed DNA polymerase activity
DIR45_RS23220	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DIR45_RS23245	COG4109	DRTGG domain
DIR45_RS23255	COG0006	proline dipeptidase activity
DIR45_RS23290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_RS23295	COG0662	Cupin 2, conserved barrel domain protein
DIR45_RS23305	COG1476	TRANSCRIPTIONal
DIR45_RS23320	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_RS23325	COG0589	response to stress
DIR45_RS23370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_RS23390	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DIR45_RS23395	COG0827	DNA restriction-modification system
DIR45_RS23400	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DIR45_RS23405	COG3874	Sporulation protein YtfJ
DIR45_RS23420	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DIR45_RS23430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DIR45_RS23445	COG1104	cysteine desulfurase activity
DIR45_RS23455	COG0583	DNA-binding transcription factor activity
DIR45_RS23460	COG0697	spore germination
DIR45_RS23470	COG1956	GAF domain-containing protein
DIR45_RS23475	COG0626	cystathionine gamma-synthase activity
DIR45_RS23505	COG1595	DNA-templated transcription, initiation
DIR45_RS23520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DIR45_RS23525	COG0454	-acetyltransferase
DIR45_RS23530	COG0517	IMP dehydrogenase activity
DIR45_RS23535	COG0123	including yeast histone deacetylase and acetoin utilization protein
DIR45_RS23545	COG0745	RESPONSE REGULATOR receiver
DIR45_RS23555	COG0666	response to abiotic stimulus
DIR45_RS23590	COG1609	Transcriptional regulator
DIR45_RS23600	COG4851	CamS sex pheromone cAM373 precursor
DIR45_RS23605	COG3118	belongs to the thioredoxin family
DIR45_RS23615	COG2309	aminopeptidase activity
DIR45_RS23635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_RS23650	COG1674	ftsk spoiiie
DIR45_RS23660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DIR45_RS23665	COG4848	Belongs to the UPF0354 family
DIR45_RS23670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DIR45_RS23675	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DIR45_RS23680	COG1363	Peptidase, m42
DIR45_RS23690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_RS23705	COG0510	thiamine kinase activity
DIR45_RS23710	COG1523	belongs to the glycosyl hydrolase 13 family
DIR45_RS23720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DIR45_RS23725	COG1349	DNA-binding transcription factor activity
DIR45_RS23730	COG1187	pseudouridine synthase activity
DIR45_RS23735	COG2244	polysaccharide biosynthetic process
DIR45_RS23740	COG2081	HI0933 family
DIR45_RS23745	COG2814	Major facilitator Superfamily
DIR45_RS23755	COG3832	glyoxalase III activity
DIR45_RS23780	COG1329	Transcriptional regulator
DIR45_RS23790	COG4975	Glucose uptake
DIR45_RS23805	COG0314	molybdopterin synthase activity
DIR45_RS23810	COG1763	Mo-molybdopterin cofactor biosynthetic process
DIR45_RS23815	COG0303	'Molybdopterin
DIR45_RS23825	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DIR45_RS23830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DIR45_RS23850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DIR45_RS23860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DIR45_RS23900	COG2814	Major facilitator Superfamily
DIR45_RS23905	COG0475	glutathione-regulated potassium exporter activity
DIR45_RS23910	COG0490	domain, Protein
DIR45_RS23915	COG0582	viral genome integration into host DNA
DIR45_RS23925	COG1136	(ABC) transporter
DIR45_RS23945	COG1242	4 iron, 4 sulfur cluster binding
DIR45_RS23950	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DIR45_RS23960	COG1131	(ABC) transporter
DIR45_RS23970	COG1794	racemase activity, acting on amino acids and derivatives
DIR45_RS23995	COG2267	carboxylic ester hydrolase activity
DIR45_RS24000	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DIR45_RS24005	COG0671	phosphoesterase, PA-phosphatase related
DIR45_RS24010	COG0438	transferase activity, transferring glycosyl groups
DIR45_RS24020	COG0521	Mo-molybdopterin cofactor biosynthetic process
DIR45_RS24070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DIR45_RS24075	COG5002	protein histidine kinase activity
DIR45_RS24080	COG4191	Histidine kinase
DIR45_RS24085	COG2267	carboxylic ester hydrolase activity
DIR45_RS24105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DIR45_RS24110	COG1116	anion transmembrane transporter activity
DIR45_RS24115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DIR45_RS24140	COG0494	nUDIX hydrolase
DIR45_RS24175	COG0288	reversible hydration of carbon dioxide
DIR45_RS24180	COG1271	oxidase subunit
DIR45_RS24185	COG1294	oxidase, subunit
DIR45_RS24205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_RS24230	COG1842	Phage shock protein A
DIR45_RS24265	COG5002	protein histidine kinase activity
DIR45_RS24270	COG0745	RESPONSE REGULATOR receiver
DIR45_RS24295	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DIR45_RS24300	COG1597	lipid kinase activity
DIR45_RS24335	COG0586	Pfam SNARE associated Golgi protein
DIR45_RS24345	COG0577	efflux transmembrane transporter activity
DIR45_RS24350	COG1136	(ABC) transporter
DIR45_RS24355	COG2207	Transcriptional regulator
DIR45_RS24355	COG3708	Transcriptional regulator
DIR45_RS24360	COG0745	RESPONSE REGULATOR receiver
DIR45_RS24365	COG2205	protein histidine kinase activity
DIR45_RS24370	COG0577	efflux transmembrane transporter activity
DIR45_RS24375	COG0577	efflux transmembrane transporter activity
DIR45_RS24380	COG1136	(ABC) transporter
DIR45_RS24400	COG2188	Transcriptional regulator
DIR45_RS24420	COG3964	amidohydrolase
DIR45_RS24450	COG4948	Mandelate Racemase Muconate Lactonizing
DIR45_RS24460	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DIR45_RS24465	COG0596	Alpha beta hydrolase
DIR45_RS24470	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DIR45_RS24475	COG1169	isochorismate synthase
DIR45_RS24480	COG1575	Belongs to the MenA family. Type 1 subfamily
DIR45_RS24485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DIR45_RS24505	COG0058	SHG alpha-glucan phosphorylase activity
DIR45_RS24510	COG0297	glycogen (starch) synthase activity
DIR45_RS24515	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DIR45_RS24645	COG0544	peptidyl-prolyl cis-trans isomerase activity
DIR45_RS24680	COG1285	pathogenesis
DIR45_RS24685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DIR45_RS24695	COG0166	Belongs to the GPI family
DIR45_RS24705	COG2155	Conserved Protein
DIR45_RS24710	COG1098	S1 RNA binding domain
DIR45_RS24715	COG0436	Aminotransferase
DIR45_RS24720	COG1522	sequence-specific DNA binding
DIR45_RS24725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DIR45_RS24730	COG2267	carboxylic ester hydrolase activity
DIR45_RS24740	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DIR45_RS24755	COG5018	Exonuclease
DIR45_RS24760	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DIR45_RS24780	COG2050	protein possibly involved in aromatic compounds catabolism
DIR45_RS24790	COG1268	BioY protein
DIR45_RS24800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DIR45_RS24805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DIR45_RS24820	COG3584	3D domain protein
DIR45_RS24835	COG1252	NADH dehydrogenase
DIR45_RS24850	COG3708	Transcriptional regulator
DIR45_RS24865	COG1683	Conserved Protein
DIR45_RS24885	COG0316	Belongs to the HesB IscA family
DIR45_RS24900	COG1252	NADH dehydrogenase
DIR45_RS24910	COG2274	protein secretion by the type I secretion system
DIR45_RS24915	COG0390	transport system, permease component
DIR45_RS24925	COG2824	Alkylphosphonate utilization operon protein PhnA
DIR45_RS24965	COG4837	Protein of unknown function (DUF1462)
DIR45_RS24970	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DIR45_RS24980	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DIR45_RS24985	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DIR45_RS24995	COG2249	NAD(P)H dehydrogenase (quinone) activity
DIR45_RS25000	COG0647	UMP catabolic process
DIR45_RS25010	COG2445	Protein of unknown function DUF86
DIR45_RS25015	COG1494	fructose-1,6-bisphosphatase
DIR45_RS25035	COG4470	Protein conserved in bacteria
DIR45_RS25045	COG0789	Transcriptional regulator
DIR45_RS25050	COG4377	Putative membrane peptidase family (DUF2324)
DIR45_RS25075	COG0739	heme binding
DIR45_RS25085	COG3377	Domain of unknown function (DUF1805)
DIR45_RS25090	COG0737	Belongs to the 5'-nucleotidase family
DIR45_RS25105	COG1695	Transcriptional regulator
DIR45_RS25120	COG0719	Fe-S assembly protein
DIR45_RS25125	COG0822	iron-sulfur transferase activity
DIR45_RS25130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DIR45_RS25135	COG0719	Fe-S assembly protein
DIR45_RS25140	COG0396	ATPase activity
DIR45_RS25145	COG1464	Belongs to the NlpA lipoprotein family
DIR45_RS25150	COG1464	Belongs to the NlpA lipoprotein family
DIR45_RS25155	COG2011	ABC-type metal ion transport system permease component
DIR45_RS25160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DIR45_RS25170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DIR45_RS25175	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DIR45_RS25190	COG1393	Belongs to the ArsC family
DIR45_RS25245	COG0039	L-malate dehydrogenase activity
DIR45_RS25265	COG1309	transcriptional regulator
DIR45_RS25270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_RS25275	COG1960	acyl-CoA dehydrogenase activity
DIR45_RS25280	COG0183	Belongs to the thiolase family
DIR45_RS25285	COG1024	Enoyl-CoA hydratase
DIR45_RS25285	COG1250	3-hydroxyacyl-CoA dehydrogenase
DIR45_RS25295	COG1686	Belongs to the peptidase S11 family
DIR45_RS25310	COG0011	TIGRFAM Protein of
DIR45_RS25315	COG0840	transmembrane signaling receptor activity
DIR45_RS25330	COG2814	Major facilitator Superfamily
DIR45_RS25335	COG0531	amino acid
DIR45_RS25345	COG0706	membrane insertase activity
DIR45_RS25355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_RS25390	COG0586	Pfam SNARE associated Golgi protein
DIR45_RS25400	COG1376	ErfK ybiS ycfS ynhG family protein
DIR45_RS25405	COG0745	RESPONSE REGULATOR receiver
DIR45_RS25410	COG5002	protein histidine kinase activity
DIR45_RS25435	COG2151	metal-sulfur cluster biosynthetic enzyme
DIR45_RS25440	COG3227	Zinc metalloprotease (Elastase)
DIR45_RS25445	COG1741	Belongs to the pirin family
DIR45_RS25460	COG0475	glutathione-regulated potassium exporter activity
DIR45_RS25465	COG0490	domain, Protein
DIR45_RS25470	COG1115	amino acid carrier protein
DIR45_RS25475	COG0783	Belongs to the Dps family
DIR45_RS25490	COG1611	Belongs to the LOG family
DIR45_RS25510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DIR45_RS25515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DIR45_RS25520	COG1115	amino acid carrier protein
DIR45_RS25525	COG1115	amino acid carrier protein
DIR45_RS25530	COG2910	NAD(P)H-binding
DIR45_RS25545	COG0656	L-ascorbic acid biosynthetic process
DIR45_RS25550	COG2814	Major facilitator Superfamily
DIR45_RS25555	COG1733	regulation of RNA biosynthetic process
DIR45_RS25565	COG1252	NADH dehydrogenase
DIR45_RS25570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DIR45_RS25575	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DIR45_RS25585	COG3290	protein histidine kinase activity
DIR45_RS25585	COG0840	transmembrane signaling receptor activity
DIR45_RS25595	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DIR45_RS25600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DIR45_RS25615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_RS25675	COG0557	exoribonuclease II activity
DIR45_RS25680	COG1647	Serine aminopeptidase, S33
DIR45_RS25685	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DIR45_RS25690	COG1346	cytolysis
DIR45_RS25790	COG4695	Portal protein
DIR45_RS25810	COG4974	Belongs to the 'phage' integrase family
DIR45_RS25825	COG0149	triose-phosphate isomerase activity
DIR45_RS25835	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DIR45_RS25850	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DIR45_RS25875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DIR45_RS25890	COG2323	membrane
DIR45_RS25895	COG0740	serine-type endopeptidase activity
DIR45_RS25905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DIR45_RS25915	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DIR45_RS25925	COG1051	belongs to the nudix hydrolase family
DIR45_RS25935	COG0492	ferredoxin-NADP+ reductase activity
DIR45_RS25940	COG0457	Tetratricopeptide repeat
DIR45_RS25945	COG0110	maltose O-acetyltransferase activity
DIR45_RS25965	COG1950	PFAM Membrane protein of
DIR45_RS25975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DIR45_RS25980	COG0556	nucleotide-excision repair
DIR45_RS26000	COG0789	Transcriptional regulator
DIR45_RS26030	COG2855	membrane
DIR45_RS26035	COG0583	DNA-binding transcription factor activity
DIR45_RS26045	COG0655	NAD(P)H dehydrogenase (quinone) activity
DIR45_RS26050	COG0488	(ABC) transporter
DIR45_RS26060	COG1132	(ABC) transporter
DIR45_RS26065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DIR45_RS26070	COG0793	Belongs to the peptidase S41A family
DIR45_RS26070	COG3409	Peptidoglycan-binding domain 1 protein
DIR45_RS26075	COG2177	Part of the ABC transporter FtsEX involved in
DIR45_RS26080	COG2884	Cell division ATP-binding protein ftsE
DIR45_RS26095	COG0653	protein targeting
DIR45_RS26100	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DIR45_RS26105	COG1278	Cold shock
DIR45_RS26110	COG1040	competence protein
DIR45_RS26115	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DIR45_RS26120	COG1388	LysM domain
DIR45_RS26120	COG0791	NLP P60 protein
DIR45_RS26125	COG1733	regulation of RNA biosynthetic process
DIR45_RS26130	COG1307	EDD domain protein, DegV family
DIR45_RS26135	COG1739	Uncharacterized protein family UPF0029
DIR45_RS26140	COG1316	TRANSCRIPTIONal
DIR45_RS26145	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DIR45_RS26150	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DIR45_RS26155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DIR45_RS26165	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DIR45_RS26165	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DIR45_RS26180	COG3394	polysaccharide catabolic process
DIR45_RS26185	COG1486	melibiose metabolic process
DIR45_RS26190	COG1447	Phosphotransferase system cellobiose-specific component IIA
DIR45_RS26195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DIR45_RS26205	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DIR45_RS26210	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DIR45_RS26215	COG1447	Phosphotransferase system cellobiose-specific component IIA
DIR45_RS26225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DIR45_RS26230	COG1301	dicarboxylic acid transport
DIR45_RS26240	COG0346	lactoylglutathione lyase activity
DIR45_RS26245	COG1511	domain protein
DIR45_RS26250	COG0583	DNA-binding transcription factor activity
DIR45_RS26255	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DIR45_RS26265	COG1271	oxidase subunit
DIR45_RS26270	COG1294	oxidase, subunit
DIR45_RS26275	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DIR45_RS26285	COG1620	l-lactate permease
DIR45_RS26295	COG2389	metal-binding protein
DIR45_RS26310	COG1368	sulfuric ester hydrolase activity
DIR45_RS26325	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DIR45_RS26335	COG1215	transferase activity, transferring glycosyl groups
DIR45_RS26340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DIR45_RS26350	COG3584	3D domain protein
DIR45_RS26350	COG1388	LysM domain
DIR45_RS26375	COG4715	Zinc finger, swim domain protein
DIR45_RS26380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DIR45_RS26420	COG0577	efflux transmembrane transporter activity
DIR45_RS26425	COG1136	(ABC) transporter
DIR45_RS26460	COG5002	protein histidine kinase activity
DIR45_RS26465	COG0745	RESPONSE REGULATOR receiver
DIR45_RS26470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DIR45_RS26490	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DIR45_RS26495	COG1134	teichoic acid transport
DIR45_RS26500	COG1682	transport, permease protein
DIR45_RS26505	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DIR45_RS26545	COG1609	Transcriptional regulator
DIR45_RS26560	COG0739	heme binding
DIR45_RS26580	COG2385	sporulation resulting in formation of a cellular spore
DIR45_RS26595	COG4836	Membrane
DIR45_RS26600	COG1007	ATP synthesis coupled electron transport
DIR45_RS26605	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIR45_RS26610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DIR45_RS26620	COG0839	Belongs to the complex I subunit 6 family
DIR45_RS26635	COG0649	NAD binding
DIR45_RS26640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIR45_RS26655	COG5001	Diguanylate cyclase
DIR45_RS26655	COG3300	MHYT domain
DIR45_RS26705	COG0356	it plays a direct role in the translocation of protons across the membrane
DIR45_RS26740	COG0698	ribose 5-phosphate isomerase
DIR45_RS26750	COG2190	(PTS) system
DIR45_RS26755	COG2259	Doxx family
DIR45_RS26760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DIR45_RS26775	COG0009	L-threonylcarbamoyladenylate synthase
DIR45_RS26790	COG2890	protein-(glutamine-N5) methyltransferase activity
DIR45_RS26810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DIR45_RS26815	COG1494	fructose-1,6-bisphosphatase
DIR45_RS26835	COG4821	SIS domain
DIR45_RS26845	COG3343	RNA polymerase activity
DIR45_RS26855	COG1960	acyl-CoA dehydrogenase activity
DIR45_RS26860	COG1960	acyl-CoA dehydrogenase activity
DIR45_RS26865	COG1250	3-hydroxyacyl-CoA dehydrogenase
DIR45_RS26870	COG0183	Belongs to the thiolase family
DIR45_RS26875	COG2181	nitrate reductase activity
DIR45_RS26875	COG0247	lactate metabolic process
DIR45_RS26880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DIR45_RS26890	COG3300	MHYT domain
DIR45_RS26890	COG5001	Diguanylate cyclase
DIR45_RS26910	COG2197	response regulator
DIR45_RS26915	COG4585	Histidine kinase
DIR45_RS26920	COG0842	Transport permease protein
DIR45_RS26925	COG1131	(ABC) transporter
DIR45_RS26930	COG0024	Methionine aminopeptidase
DIR45_RS26945	COG2234	aminopeptidase activity
DIR45_RS26965	COG1595	DNA-templated transcription, initiation
DIR45_RS26970	COG0018	arginyl-trna synthetase
DIR45_RS26975	COG4506	Protein conserved in bacteria
DIR45_RS26980	COG1619	proteins homologs of microcin C7 resistance protein MccF
DIR45_RS26995	COG0010	Belongs to the arginase family
DIR45_RS27005	COG2814	Major facilitator Superfamily
DIR45_RS27010	COG0789	Transcriptional regulator
DIR45_RS27015	COG0584	glycerophosphoryl diester phosphodiesterase
DIR45_RS27020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DIR45_RS27030	COG1994	Peptidase M50
DIR45_RS27040	COG1078	dGTPase activity
DIR45_RS27045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DIR45_RS27050	COG1120	ATPase activity
DIR45_RS27055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_RS27060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_RS27080	COG0095	Lipoate-protein ligase
DIR45_RS27085	COG0280	phosphate acetyltransferase
DIR45_RS27100	COG3773	Cell wall hydrolase
DIR45_RS27110	COG2363	Small membrane protein
DIR45_RS27120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DIR45_RS27125	COG2233	PERMEase
DIR45_RS27130	COG0561	phosphatase activity
DIR45_RS27135	COG2814	Major facilitator Superfamily
DIR45_RS27145	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DIR45_RS27150	COG1131	(ABC) transporter
DIR45_RS27155	COG2755	lipolytic protein G-D-S-L family
DIR45_RS27160	COG1609	Transcriptional regulator
DIR45_RS27170	COG0460	homoserine dehydrogenase
DIR45_RS27180	COG2873	o-acetylhomoserine
DIR45_RS27190	COG1011	Hydrolase
DIR45_RS27195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DIR45_RS27205	COG2197	response regulator
DIR45_RS27215	COG0351	phosphomethylpyrimidine kinase
DIR45_RS27220	COG3706	GGDEF domain
DIR45_RS27225	COG2879	small protein
DIR45_RS27230	COG1966	Carbon starvation protein
DIR45_RS27235	COG3279	Response regulator of the LytR AlgR family
DIR45_RS27240	COG0477	Major facilitator Superfamily
DIR45_RS27265	COG0840	transmembrane signaling receptor activity
DIR45_RS27275	COG1607	acyl-coa hydrolase
DIR45_RS27290	COG0488	(ABC) transporter
DIR45_RS27315	COG0463	Glycosyl transferase, family 2
DIR45_RS27320	COG1309	transcriptional regulator
DIR45_RS27325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DIR45_RS27330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DIR45_RS27330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DIR45_RS27335	COG0628	permease
DIR45_RS27350	COG3279	Response regulator of the LytR AlgR family
DIR45_RS27355	COG3275	phosphorelay sensor kinase activity
DIR45_RS27360	COG2814	Major facilitator Superfamily
DIR45_RS27365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DIR45_RS27370	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DIR45_RS27380	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DIR45_RS27400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DIR45_RS27405	COG1272	protein, Hemolysin III
DIR45_RS27430	COG1164	Oligoendopeptidase f
DIR45_RS27450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DIR45_RS27455	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DIR45_RS27465	COG4863	YycH protein
DIR45_RS27470	COG5002	protein histidine kinase activity
DIR45_RS27475	COG0745	RESPONSE REGULATOR receiver
DIR45_RS27505	COG0305	Participates in initiation and elongation during chromosome replication
DIR45_RS27515	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DIR45_RS27520	COG4241	membrane
DIR45_RS27530	COG0629	single-stranded DNA binding
DIR45_RS27540	COG0012	GTP binding
DIR45_RS27545	COG4481	Protein conserved in bacteria
DIR45_RS27550	COG0668	transmembrane transport
DIR45_RS27560	COG1475	DNA binding
DIR45_RS27565	COG1192	Involved in chromosome partitioning
DIR45_RS27590	COG1847	R3H domain protein
DIR45_RS27595	COG0706	membrane insertase activity
DIR45_RS27605	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DIR45_RS27685	COG3344	reverse transcriptase
DIR45_RS27780	COG3344	reverse transcriptase
DIR45_RS27880	COG0457	Tetratricopeptide repeat
DIR45_RS27905	COG4974	Belongs to the 'phage' integrase family
DIR45_RS27920	COG3443	Belongs to the bacterial solute-binding protein 9 family
DIR45_RS27975	COG4974	Belongs to the 'phage' integrase family
DIR45_RS28160	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DIR45_RS28165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DIR45_RS28170	COG1215	transferase activity, transferring glycosyl groups
DIR45_RS28195	COG0671	phosphoesterase, PA-phosphatase related
DIR45_RS28200	COG4196	transglutaminase domain protein
DIR45_RS28220	COG2311	Membrane
DIR45_RS28360	COG4962	Type ii secretion system protein e
DIR45_RS28625	COG1192	Involved in chromosome partitioning
DIR45_RS28680	COG1683	Conserved Protein
DIR45_RS28685	COG1309	transcriptional regulator
DIR45_RS28770	COG0681	Belongs to the peptidase S26 family
DIR45_RS28800	COG1280	lysine exporter protein (LysE YggA)
DIR45_RS28840	COG4166	transmembrane transport
DIR45_RS28855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII