locus-tag	class	description
KM392_RS00010	COG0592	DNA-directed DNA polymerase activity
KM392_RS00015	COG2501	S4 domain
KM392_RS00025	COG0187	DNA topoisomerase II activity
KM392_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KM392_RS00065	COG0516	GMP reductase activity
KM392_RS00065	COG0517	IMP dehydrogenase activity
KM392_RS00070	COG1686	Belongs to the peptidase S11 family
KM392_RS00100	COG1428	Deoxynucleoside kinase
KM392_RS00105	COG1428	Deoxynucleoside kinase
KM392_RS00110	COG1335	isochorismatase
KM392_RS00115	COG0590	tRNA wobble adenosine to inosine editing
KM392_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KM392_RS00180	COG1982	Orn Lys Arg decarboxylase major
KM392_RS00190	COG0470	DNA polymerase III
KM392_RS00195	COG1774	PSP1 C-terminal conserved region
KM392_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KM392_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KM392_RS00220	COG2002	toxin-antitoxin pair type II binding
KM392_RS00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM392_RS00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM392_RS00230	COG0084	hydrolase, TatD family'
KM392_RS00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KM392_RS00250	COG4466	Protein conserved in bacteria
KM392_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KM392_RS00270	COG0251	oxidation-reduction process
KM392_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KM392_RS00305	COG2002	toxin-antitoxin pair type II binding
KM392_RS00310	COG2244	polysaccharide biosynthetic process
KM392_RS00315	COG3956	TIGRFAM MazG family protein
KM392_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KM392_RS00340	COG1098	S1 RNA binding domain
KM392_RS00355	COG2208	phosphoserine phosphatase activity
KM392_RS00360	COG0037	tRNA processing
KM392_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KM392_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KM392_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM392_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KM392_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
KM392_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM392_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KM392_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KM392_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KM392_RS00420	COG1396	sequence-specific DNA binding
KM392_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM392_RS00455	COG3880	PFAM UvrB UvrC protein
KM392_RS00465	COG0542	response to heat
KM392_RS00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KM392_RS00480	COG4956	integral membrane protein (PIN domain superfamily)
KM392_RS00500	COG1045	serine acetyltransferase
KM392_RS00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM392_RS00520	COG3688	RNA-binding protein containing a PIN domain
KM392_RS00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM392_RS00540	COG0250	Participates in transcription elongation, termination and antitermination
KM392_RS00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KM392_RS00565	COG2813	Specifically methylates the guanine in position
KM392_RS00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KM392_RS00580	COG1358	cellular component organization or biogenesis
KM392_RS00650	COG0255	Belongs to the universal ribosomal protein uL29 family
KM392_RS00710	COG0201	protein transport
KM392_RS00720	COG0024	Methionine aminopeptidase
KM392_RS00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KM392_RS00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KM392_RS00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM392_RS00795	COG0489	protein tyrosine kinase activity
KM392_RS00805	COG2194	sulfuric ester hydrolase activity
KM392_RS00810	COG0726	polysaccharide deacetylase
KM392_RS00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KM392_RS00895	COG4856	YbbR-like protein
KM392_RS00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KM392_RS00915	COG0596	Alpha beta hydrolase
KM392_RS00935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KM392_RS00940	COG4946	Tricorn protease homolog
KM392_RS00940	COG1506	peptidase
KM392_RS00940	COG0823	Involved in the tonB-independent uptake of proteins
KM392_RS00975	COG2011	ABC-type metal ion transport system permease component
KM392_RS00980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM392_RS00985	COG1464	Belongs to the NlpA lipoprotein family
KM392_RS00990	COG0604	alcohol dehydrogenase
KM392_RS01005	COG2271	Major facilitator Superfamily
KM392_RS01015	COG2814	Major facilitator Superfamily
KM392_RS01030	COG0601	transmembrane transport
KM392_RS01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM392_RS01040	COG0444	Belongs to the ABC transporter superfamily
KM392_RS01045	COG4608	Belongs to the ABC transporter superfamily
KM392_RS01050	COG4166	transmembrane transport
KM392_RS01060	COG2207	Transcriptional regulator
KM392_RS01075	COG4166	transmembrane transport
KM392_RS01080	COG4166	transmembrane transport
KM392_RS01085	COG0656	L-ascorbic acid biosynthetic process
KM392_RS01105	COG4149	molybdate abc transporter
KM392_RS01110	COG0725	ABC transporter, periplasmic molybdate-binding protein
KM392_RS01115	COG1910	domain protein
KM392_RS01125	COG0583	DNA-binding transcription factor activity
KM392_RS01130	COG0697	spore germination
KM392_RS01145	COG0204	Acyl-transferase
KM392_RS01155	COG1609	Transcriptional regulator
KM392_RS01165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM392_RS01175	COG0084	hydrolase, TatD family'
KM392_RS01180	COG5298	Protein conserved in bacteria
KM392_RS01205	COG0488	(ABC) transporter
KM392_RS01220	COG0747	negative chemotaxis
KM392_RS01225	COG0601	transmembrane transport
KM392_RS01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM392_RS01235	COG0444	Belongs to the ABC transporter superfamily
KM392_RS01240	COG4608	Belongs to the ABC transporter superfamily
KM392_RS01265	COG3185	4-Hydroxyphenylpyruvate dioxygenase
KM392_RS01270	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM392_RS01280	COG2814	Major facilitator Superfamily
KM392_RS01290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KM392_RS01300	COG4294	response to UV
KM392_RS01305	COG0457	Tetratricopeptide repeat
KM392_RS01305	COG0705	Rhomboid family
KM392_RS01315	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KM392_RS01320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KM392_RS01325	COG0864	Transcriptional regulator
KM392_RS01330	COG2337	Toxic component of a toxin-antitoxin (TA) module
KM392_RS01335	COG2183	response to ionizing radiation
KM392_RS01430	COG0802	atpase or kinase
KM392_RS01435	COG1214	PFAM Peptidase M22, glycoprotease
KM392_RS01440	COG0456	acetyltransferase
KM392_RS01450	COG0488	(ABC) transporter
KM392_RS01465	COG1266	CAAX protease self-immunity
KM392_RS01485	COG2252	PERMEase
KM392_RS01495	COG5002	protein histidine kinase activity
KM392_RS01520	COG1968	undecaprenyl-diphosphatase activity
KM392_RS01535	COG2205	protein histidine kinase activity
KM392_RS01540	COG0745	RESPONSE REGULATOR receiver
KM392_RS01565	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KM392_RS01570	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KM392_RS01575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KM392_RS01585	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KM392_RS01600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KM392_RS01610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KM392_RS01620	COG0151	Belongs to the GarS family
KM392_RS01645	COG0210	DNA helicase
KM392_RS01655	COG4851	CamS sex pheromone cAM373 precursor
KM392_RS01675	COG1335	isochorismatase
KM392_RS01680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM392_RS01685	COG2011	ABC-type metal ion transport system permease component
KM392_RS01690	COG1464	Belongs to the NlpA lipoprotein family
KM392_RS01715	COG1846	Transcriptional regulator
KM392_RS01740	COG1597	lipid kinase activity
KM392_RS01745	COG0546	phosphoglycolate phosphatase activity
KM392_RS01750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM392_RS01760	COG1012	belongs to the aldehyde dehydrogenase family
KM392_RS01765	COG2076	Multidrug Resistance protein
KM392_RS01770	COG2309	aminopeptidase activity
KM392_RS01785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM392_RS01790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KM392_RS01795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM392_RS01805	COG4807	Protein conserved in bacteria
KM392_RS01830	COG1757	Na H antiporter
KM392_RS01835	COG1473	amidohydrolase
KM392_RS01850	COG0450	alkyl hydroperoxide reductase
KM392_RS01870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM392_RS01875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM392_RS01880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM392_RS01895	COG0166	Belongs to the GPI family
KM392_RS01930	COG5002	protein histidine kinase activity
KM392_RS01950	COG3541	Predicted nucleotidyltransferase
KM392_RS01955	COG2814	Major facilitator Superfamily
KM392_RS01960	COG0723	plastoquinol--plastocyanin reductase activity
KM392_RS01960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM392_RS01970	COG0765	amino acid transport
KM392_RS01975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM392_RS01985	COG0840	transmembrane signaling receptor activity
KM392_RS01990	COG0840	transmembrane signaling receptor activity
KM392_RS01995	COG0366	Alpha amylase catalytic
KM392_RS02000	COG2190	(PTS) system
KM392_RS02000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM392_RS02000	COG1263	PTS System
KM392_RS02030	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KM392_RS02045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM392_RS02055	COG1116	anion transmembrane transporter activity
KM392_RS02060	COG0488	(ABC) transporter
KM392_RS02105	COG2270	Major facilitator Superfamily
KM392_RS02120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM392_RS02135	COG2310	stress, protein
KM392_RS02140	COG2310	stress, protein
KM392_RS02145	COG2310	stress, protein
KM392_RS02150	COG0861	Integral membrane protein TerC family
KM392_RS02160	COG3853	Toxic anion resistance protein (TelA)
KM392_RS02175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KM392_RS02185	COG1295	ribonuclease BN
KM392_RS02190	COG2217	Heavy metal translocating P-type atpase
KM392_RS02195	COG0697	spore germination
KM392_RS02215	COG0586	Pfam SNARE associated Golgi protein
KM392_RS02230	COG3871	stress protein (general stress protein 26)
KM392_RS02235	COG0387	Pfam Sodium calcium exchanger
KM392_RS02245	COG0535	radical SAM domain protein
KM392_RS02270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KM392_RS02275	COG0582	viral genome integration into host DNA
KM392_RS02285	COG1396	sequence-specific DNA binding
KM392_RS02300	COG1396	sequence-specific DNA binding
KM392_RS02335	COG1484	DNA-dependent DNA replication
KM392_RS02565	COG0101	tRNA pseudouridine synthase activity
KM392_RS02575	COG3829	transcription factor binding
KM392_RS02585	COG0833	amino acid
KM392_RS02590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM392_RS02620	COG1263	PTS System
KM392_RS02620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM392_RS02625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM392_RS02640	COG0463	Glycosyl transferase, family 2
KM392_RS02650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KM392_RS02650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM392_RS02665	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KM392_RS02685	COG1228	amidohydrolase
KM392_RS02690	COG1090	epimerase
KM392_RS02720	COG1988	membrane-bound metal-dependent
KM392_RS02725	COG1194	a g-specific adenine glycosylase
KM392_RS02750	COG1132	(ABC) transporter
KM392_RS02755	COG4129	membrane
KM392_RS02760	COG0070	glutamate synthase
KM392_RS02760	COG0067	glutamate synthase
KM392_RS02760	COG0069	glutamate synthase activity
KM392_RS02770	COG4555	ABC transporter
KM392_RS02790	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KM392_RS02795	COG0735	belongs to the Fur family
KM392_RS02910	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KM392_RS02915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KM392_RS02925	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KM392_RS02935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KM392_RS02945	COG2766	serine protein kinase
KM392_RS02965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM392_RS02975	COG1585	Membrane protein implicated in regulation of membrane protease activity
KM392_RS02980	COG2268	Band 7 protein
KM392_RS02990	COG3290	protein histidine kinase activity
KM392_RS02995	COG4565	transcriptional regulatory protein
KM392_RS03000	COG2851	Citrate transporter
KM392_RS03020	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KM392_RS03025	COG3842	ATPase activity
KM392_RS03030	COG1175	transmembrane transport
KM392_RS03035	COG0395	ABC-type sugar transport system, permease component
KM392_RS03045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KM392_RS03050	COG0745	RESPONSE REGULATOR receiver
KM392_RS03055	COG5002	protein histidine kinase activity
KM392_RS03065	COG4990	cell redox homeostasis
KM392_RS03075	COG3290	protein histidine kinase activity
KM392_RS03080	COG4565	transcriptional regulatory protein
KM392_RS03085	COG3493	citrate carrier protein
KM392_RS03090	COG0281	malic enzyme
KM392_RS03105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM392_RS03115	COG5002	protein histidine kinase activity
KM392_RS03120	COG0745	RESPONSE REGULATOR receiver
KM392_RS03125	COG0454	-acetyltransferase
KM392_RS03125	COG0456	acetyltransferase
KM392_RS03130	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KM392_RS03135	COG3383	formate dehydrogenase (NAD+) activity
KM392_RS03155	COG0531	amino acid
KM392_RS03160	COG0640	Transcriptional regulator
KM392_RS03165	COG2217	Heavy metal translocating P-type atpase
KM392_RS03170	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KM392_RS03185	COG3227	Zinc metalloprotease (Elastase)
KM392_RS03205	COG2720	vancomycin resistance protein
KM392_RS03210	COG1316	TRANSCRIPTIONal
KM392_RS03215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM392_RS03220	COG0346	lactoylglutathione lyase activity
KM392_RS03230	COG1027	Aspartate ammonia-lyase
KM392_RS03235	COG1620	l-lactate permease
KM392_RS03250	COG3104	oligopeptide transport
KM392_RS03255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM392_RS03260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM392_RS03265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM392_RS03275	COG2226	methyltransferase
KM392_RS03280	COG0156	8-amino-7-oxononanoate synthase activity
KM392_RS03285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM392_RS03295	COG4548	von Willebrand factor, type A
KM392_RS03300	COG0714	Associated with various cellular activities
KM392_RS03305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM392_RS03325	COG0531	amino acid
KM392_RS03330	COG2188	Transcriptional regulator
KM392_RS03335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM392_RS03335	COG1263	PTS System
KM392_RS03340	COG0366	Alpha amylase catalytic
KM392_RS03355	COG0697	spore germination
KM392_RS03365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM392_RS03370	COG1115	amino acid carrier protein
KM392_RS03375	COG1126	abc transporter atp-binding protein
KM392_RS03380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM392_RS03385	COG0765	amino acid transport
KM392_RS03390	COG0765	amino acid transport
KM392_RS03395	COG0833	amino acid
KM392_RS03420	COG2378	regulation of single-species biofilm formation
KM392_RS03425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KM392_RS03430	COG5002	protein histidine kinase activity
KM392_RS03445	COG0659	secondary active sulfate transmembrane transporter activity
KM392_RS03460	COG0747	negative chemotaxis
KM392_RS03470	COG0601	transmembrane transport
KM392_RS03475	COG4608	Belongs to the ABC transporter superfamily
KM392_RS03485	COG2271	Major facilitator Superfamily
KM392_RS03490	COG1846	Transcriptional regulator
KM392_RS03500	COG1609	Transcriptional regulator
KM392_RS03505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM392_RS03520	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM392_RS03525	COG1879	ABC-type sugar transport system periplasmic component
KM392_RS03550	COG1063	alcohol dehydrogenase
KM392_RS03565	COG3568	Endonuclease Exonuclease Phosphatase
KM392_RS03590	COG1968	undecaprenyl-diphosphatase activity
KM392_RS03595	COG0840	transmembrane signaling receptor activity
KM392_RS03600	COG1388	LysM domain
KM392_RS03600	COG3584	3D domain protein
KM392_RS03605	COG1476	TRANSCRIPTIONal
KM392_RS03620	COG3104	oligopeptide transport
KM392_RS03625	COG1114	Component of the transport system for branched-chain amino acids
KM392_RS03640	COG1113	amino acid transport
KM392_RS03645	COG2252	PERMEase
KM392_RS03670	COG0475	glutathione-regulated potassium exporter activity
KM392_RS03670	COG0569	domain protein
KM392_RS03685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KM392_RS03690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KM392_RS03695	COG4990	cell redox homeostasis
KM392_RS03710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM392_RS03715	COG0697	spore germination
KM392_RS03720	COG0531	amino acid
KM392_RS03730	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM392_RS03735	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM392_RS03740	COG1918	ferrous iron import across plasma membrane
KM392_RS03740	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM392_RS03745	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM392_RS03750	COG0573	inorganic phosphate transmembrane transporter activity
KM392_RS03755	COG0581	inorganic phosphate transmembrane transporter activity
KM392_RS03765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM392_RS03885	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KM392_RS03905	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KM392_RS03910	COG1116	anion transmembrane transporter activity
KM392_RS03915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM392_RS03920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM392_RS03925	COG0352	thiamine-phosphate diphosphorylase activity
KM392_RS03930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM392_RS03935	COG2104	thiamine diphosphate biosynthetic process
KM392_RS03945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM392_RS03950	COG0351	phosphomethylpyrimidine kinase
KM392_RS03990	COG2205	protein histidine kinase activity
KM392_RS03995	COG2814	Major facilitator Superfamily
KM392_RS04000	COG1846	Transcriptional regulator
KM392_RS04015	COG2252	PERMEase
KM392_RS04020	COG1028	Short-chain dehydrogenase reductase Sdr
KM392_RS04025	COG1376	ErfK ybiS ycfS ynhG family protein
KM392_RS04035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM392_RS04040	COG1621	beta-fructofuranosidase activity
KM392_RS04045	COG1263	PTS System
KM392_RS04045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM392_RS04050	COG1609	Transcriptional regulator
KM392_RS04060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM392_RS04100	COG0778	Nitroreductase
KM392_RS04105	COG2719	SpoVR family
KM392_RS04130	COG0446	pyridine nucleotide-disulphide oxidoreductase
KM392_RS04135	COG1937	Protein conserved in bacteria
KM392_RS04140	COG0425	Belongs to the sulfur carrier protein TusA family
KM392_RS04140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM392_RS04145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM392_RS04145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM392_RS04150	COG0425	Belongs to the sulfur carrier protein TusA family
KM392_RS04165	COG2210	Belongs to the sulfur carrier protein TusA family
KM392_RS04170	COG0730	response to heat
KM392_RS04180	COG1316	TRANSCRIPTIONal
KM392_RS04185	COG0604	alcohol dehydrogenase
KM392_RS04190	COG1283	sodium-dependent phosphate transmembrane transporter activity
KM392_RS04205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM392_RS04205	COG3711	transcriptional antiterminator
KM392_RS04210	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM392_RS04215	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM392_RS04235	COG3584	3D domain protein
KM392_RS04235	COG1388	LysM domain
KM392_RS04240	COG0577	efflux transmembrane transporter activity
KM392_RS04245	COG1136	(ABC) transporter
KM392_RS04255	COG5522	Integral membrane protein (intg_mem_TP0381)
KM392_RS04270	COG1114	Component of the transport system for branched-chain amino acids
KM392_RS04275	COG3546	catalase activity
KM392_RS04310	COG0586	Pfam SNARE associated Golgi protein
KM392_RS04350	COG0531	amino acid
KM392_RS04355	COG0475	glutathione-regulated potassium exporter activity
KM392_RS04365	COG1737	Transcriptional regulator
KM392_RS04375	COG1263	PTS System
KM392_RS04375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM392_RS04385	COG2259	Doxx family
KM392_RS04400	COG0697	spore germination
KM392_RS04405	COG1522	sequence-specific DNA binding
KM392_RS04420	COG2076	Multidrug Resistance protein
KM392_RS04425	COG1309	transcriptional regulator
KM392_RS04430	COG2814	Major facilitator Superfamily
KM392_RS04435	COG1733	regulation of RNA biosynthetic process
KM392_RS04445	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM392_RS04450	COG4533	DNA binding
KM392_RS04455	COG2814	Major facilitator Superfamily
KM392_RS04465	COG0693	protein deglycase activity
KM392_RS04470	COG0693	protein deglycase activity
KM392_RS04470	COG0753	catalase activity
KM392_RS04480	COG0531	amino acid
KM392_RS04485	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KM392_RS04495	COG1012	belongs to the aldehyde dehydrogenase family
KM392_RS04500	COG1132	(ABC) transporter
KM392_RS04510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM392_RS04515	COG0765	amino acid transport
KM392_RS04520	COG1126	abc transporter atp-binding protein
KM392_RS04535	COG0189	ligase activity
KM392_RS04565	COG0028	Belongs to the TPP enzyme family
KM392_RS04570	COG3527	Alpha-acetolactate decarboxylase
KM392_RS04585	COG0561	phosphatase activity
KM392_RS04600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM392_RS04615	COG0659	secondary active sulfate transmembrane transporter activity
KM392_RS04635	COG0653	protein targeting
KM392_RS04640	COG2244	polysaccharide biosynthetic process
KM392_RS04650	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM392_RS04655	COG4196	transglutaminase domain protein
KM392_RS04670	COG1696	Membrane protein involved in D-alanine export
KM392_RS04685	COG1024	Enoyl-CoA hydratase
KM392_RS04700	COG1363	Peptidase, m42
KM392_RS04720	COG3938	Belongs to the proline racemase family
KM392_RS04760	COG0601	transmembrane transport
KM392_RS04765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM392_RS04775	COG4608	Belongs to the ABC transporter superfamily
KM392_RS04810	COG0477	Major facilitator Superfamily
KM392_RS04815	COG3290	protein histidine kinase activity
KM392_RS04820	COG4565	transcriptional regulatory protein
KM392_RS04825	COG3181	Tripartite tricarboxylate transporter family receptor
KM392_RS04855	COG0789	Transcriptional regulator
KM392_RS04855	COG4978	Transcriptional regulator
KM392_RS04870	COG0305	Participates in initiation and elongation during chromosome replication
KM392_RS04910	COG0477	Major facilitator Superfamily
KM392_RS04960	COG1309	transcriptional regulator
KM392_RS04980	COG1183	phosphatidylcholine synthase activity
KM392_RS05000	COG2376	Dihydroxyacetone kinase
KM392_RS05010	COG2376	Dihydroxyacetone kinase
KM392_RS05015	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM392_RS05020	COG1959	2 iron, 2 sulfur cluster binding
KM392_RS05050	COG2770	Histidine kinase
KM392_RS05050	COG3437	response regulator, receiver
KM392_RS05105	COG3237	CsbD-like
KM392_RS05130	COG1191	sigma factor activity
KM392_RS05140	COG2208	phosphoserine phosphatase activity
KM392_RS05145	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KM392_RS05150	COG0784	Response regulator, receiver
KM392_RS05150	COG2205	protein histidine kinase activity
KM392_RS05150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM392_RS05150	COG2198	Histidine kinase
KM392_RS05205	COG0420	3'-5' exonuclease activity
KM392_RS05230	COG1309	transcriptional regulator
KM392_RS05235	COG2814	Major facilitator Superfamily
KM392_RS05240	COG0346	lactoylglutathione lyase activity
KM392_RS05245	COG0346	lactoylglutathione lyase activity
KM392_RS05250	COG0457	Tetratricopeptide repeat
KM392_RS05255	COG2267	carboxylic ester hydrolase activity
KM392_RS05275	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KM392_RS05280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KM392_RS05290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KM392_RS05330	COG0477	Major facilitator Superfamily
KM392_RS05335	COG0477	Major facilitator Superfamily
KM392_RS05345	COG3973	AAA domain
KM392_RS05350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM392_RS05370	COG4980	gas vesicle protein
KM392_RS05375	COG0537	adenosine 5'-monophosphoramidase activity
KM392_RS05380	COG1131	(ABC) transporter
KM392_RS05385	COG4473	ABC transporter
KM392_RS05400	COG1309	transcriptional regulator
KM392_RS05410	COG3402	PFAM membrane-flanked domain
KM392_RS05455	COG3402	PFAM membrane-flanked domain
KM392_RS05460	COG3428	Bacterial PH domain
KM392_RS05465	COG2329	Antibiotic biosynthesis monooxygenase
KM392_RS05470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM392_RS05475	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KM392_RS05480	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM392_RS05485	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KM392_RS05520	COG1309	transcriptional regulator
KM392_RS05525	COG1511	domain protein
KM392_RS05550	COG1609	Transcriptional regulator
KM392_RS05560	COG1234	tRNA 3'-trailer cleavage
KM392_RS05565	COG0095	Lipoate-protein ligase
KM392_RS05575	COG0318	PFAM AMP-dependent synthetase and ligase
KM392_RS05605	COG3209	COG3209 Rhs family protein
KM392_RS05645	COG1078	dGTPase activity
KM392_RS05655	COG1595	DNA-templated transcription, initiation
KM392_RS05660	COG2207	Transcriptional regulator
KM392_RS05660	COG3708	Transcriptional regulator
KM392_RS05675	COG2205	protein histidine kinase activity
KM392_RS05680	COG0745	RESPONSE REGULATOR receiver
KM392_RS05705	COG0501	Belongs to the peptidase M48B family
KM392_RS05710	COG0840	transmembrane signaling receptor activity
KM392_RS05715	COG0697	spore germination
KM392_RS05735	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KM392_RS05740	COG2224	Isocitrate lyase
KM392_RS05765	COG4903	ComK protein
KM392_RS05770	COG0398	Pfam SNARE associated Golgi protein
KM392_RS05780	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KM392_RS05785	COG1074	ATP-dependent DNA helicase activity
KM392_RS05830	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM392_RS05855	COG0367	asparagine synthase
KM392_RS05860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM392_RS05865	COG0753	catalase activity
KM392_RS05870	COG0004	ammonium transporteR
KM392_RS05890	COG2996	Protein conserved in bacteria
KM392_RS05900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM392_RS05925	COG0561	phosphatase activity
KM392_RS05935	COG0542	response to heat
KM392_RS05945	COG2267	carboxylic ester hydrolase activity
KM392_RS05960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM392_RS05965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KM392_RS05970	COG5504	Zn-dependent protease
KM392_RS05980	COG0180	Tryptophanyl-tRNA synthetase
KM392_RS05990	COG4166	transmembrane transport
KM392_RS05995	COG0601	transmembrane transport
KM392_RS06000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM392_RS06005	COG0444	Belongs to the ABC transporter superfamily
KM392_RS06010	COG4608	Belongs to the ABC transporter superfamily
KM392_RS06015	COG0534	Mate efflux family protein
KM392_RS06020	COG4166	transmembrane transport
KM392_RS06035	COG0861	Integral membrane protein TerC family
KM392_RS06040	COG4862	establishment of competence for transformation
KM392_RS06045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM392_RS06055	COG1164	Oligoendopeptidase f
KM392_RS06065	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM392_RS06070	COG2346	COG2346, Truncated hemoglobins
KM392_RS06075	COG4116	CYTH
KM392_RS06085	COG2357	RelA SpoT domain protein
KM392_RS06095	COG0564	pseudouridine synthase activity
KM392_RS06115	COG0463	Glycosyl transferase, family 2
KM392_RS06115	COG1216	Glycosyl transferase, family 2
KM392_RS06135	COG0457	Tetratricopeptide repeat
KM392_RS06135	COG0463	Glycosyl transferase, family 2
KM392_RS06155	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KM392_RS06170	COG1091	dTDP-4-dehydrorhamnose reductase activity
KM392_RS06215	COG2153	protein acetylation
KM392_RS06225	COG2382	esterase
KM392_RS06240	COG5492	domain, Protein
KM392_RS06245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM392_RS06255	COG0512	Glutamine amidotransferase of anthranilate synthase
KM392_RS06255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KM392_RS06290	COG1620	l-lactate permease
KM392_RS06295	COG5634	Uncharacterized conserved protein (DUF2278)
KM392_RS06350	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM392_RS06360	COG1476	TRANSCRIPTIONal
KM392_RS06420	COG2226	methyltransferase
KM392_RS06430	COG1686	Belongs to the peptidase S11 family
KM392_RS06435	COG0681	Belongs to the peptidase S26 family
KM392_RS06470	COG1012	belongs to the aldehyde dehydrogenase family
KM392_RS06475	COG3842	ATPase activity
KM392_RS06480	COG1176	ABC-type spermidine putrescine transport system, permease component I
KM392_RS06485	COG1177	transmembrane transport
KM392_RS06490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KM392_RS06500	COG2409	Drug exporters of the RND superfamily
KM392_RS06510	COG0564	pseudouridine synthase activity
KM392_RS06520	COG2340	Cysteine-rich secretory protein family
KM392_RS06525	COG0247	lactate metabolic process
KM392_RS06530	COG0277	FAD linked oxidase domain protein
KM392_RS06535	COG3835	regulator
KM392_RS06545	COG0745	RESPONSE REGULATOR receiver
KM392_RS06550	COG5002	protein histidine kinase activity
KM392_RS06555	COG2186	Transcriptional regulator
KM392_RS06575	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KM392_RS06585	COG2116	formate transmembrane transporter activity
KM392_RS06590	COG0861	Integral membrane protein TerC family
KM392_RS06605	COG2030	dehydratase
KM392_RS06625	COG1028	Short-chain dehydrogenase reductase Sdr
KM392_RS06630	COG3243	poly(R)-hydroxyalkanoic acid synthase
KM392_RS06635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM392_RS06640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM392_RS06655	COG1840	ABC-type Fe3 transport system, periplasmic component
KM392_RS06685	COG1349	DNA-binding transcription factor activity
KM392_RS06705	COG2861	carbohydrate metabolic process
KM392_RS06715	COG3852	Histidine kinase
KM392_RS06720	COG1846	Transcriptional regulator
KM392_RS06730	COG2318	DinB family
KM392_RS06740	COG5002	protein histidine kinase activity
KM392_RS06750	COG0720	synthase
KM392_RS06765	COG4873	Protein conserved in bacteria
KM392_RS06795	COG1780	Probably involved in ribonucleotide reductase function
KM392_RS06815	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KM392_RS06820	COG1725	Transcriptional regulator
KM392_RS06825	COG1131	(ABC) transporter
KM392_RS06835	COG1131	(ABC) transporter
KM392_RS06840	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM392_RS06855	COG1522	sequence-specific DNA binding
KM392_RS06865	COG1335	isochorismatase
KM392_RS06875	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM392_RS06880	COG2070	2-Nitropropane dioxygenase
KM392_RS06885	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KM392_RS06895	COG1696	Membrane protein involved in D-alanine export
KM392_RS06920	COG0716	FMN binding
KM392_RS06935	COG3173	Aminoglycoside phosphotransferase
KM392_RS06955	COG0534	Mate efflux family protein
KM392_RS06960	COG1968	undecaprenyl-diphosphatase activity
KM392_RS06975	COG1846	Transcriptional regulator
KM392_RS06985	COG1301	dicarboxylic acid transport
KM392_RS06990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM392_RS06995	COG4709	membrane
KM392_RS07000	COG3874	Sporulation protein YtfJ
KM392_RS07025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM392_RS07030	COG0028	Belongs to the TPP enzyme family
KM392_RS07035	COG0440	acetolactate synthase activity
KM392_RS07040	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM392_RS07050	COG0473	3-isopropylmalate dehydrogenase activity
KM392_RS07075	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KM392_RS07110	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KM392_RS07125	COG1183	phosphatidylcholine synthase activity
KM392_RS07130	COG1368	sulfuric ester hydrolase activity
KM392_RS07140	COG0019	diaminopimelate decarboxylase activity
KM392_RS07160	COG0529	Catalyzes the synthesis of activated sulfate
KM392_RS07165	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM392_RS07185	COG1648	precorrin-2 dehydrogenase activity
KM392_RS07190	COG0733	neurotransmitter:sodium symporter activity
KM392_RS07210	COG1757	Na H antiporter
KM392_RS07225	COG4758	membrane
KM392_RS07230	COG4585	Histidine kinase
KM392_RS07235	COG2197	response regulator
KM392_RS07245	COG1114	Component of the transport system for branched-chain amino acids
KM392_RS07255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KM392_RS07280	COG1017	nitric oxide dioxygenase activity
KM392_RS07280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KM392_RS07295	COG0730	response to heat
KM392_RS07300	COG0306	phosphate transporter
KM392_RS07305	COG1392	Phosphate transport regulator
KM392_RS07330	COG1801	Protein of unknown function DUF72
KM392_RS07340	COG0582	viral genome integration into host DNA
KM392_RS07345	COG5002	protein histidine kinase activity
KM392_RS07365	COG0392	lysyltransferase activity
KM392_RS07365	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KM392_RS07380	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM392_RS07385	COG1686	Belongs to the peptidase S11 family
KM392_RS07390	COG2715	membrane protein required for spore maturation
KM392_RS07395	COG0700	Nucleoside recognition
KM392_RS07400	COG1187	pseudouridine synthase activity
KM392_RS07410	COG1333	cytochrome c biogenesis protein
KM392_RS07415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KM392_RS07420	COG0745	RESPONSE REGULATOR receiver
KM392_RS07425	COG5002	protein histidine kinase activity
KM392_RS07430	COG2096	Adenosyltransferase
KM392_RS07445	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KM392_RS07450	COG1141	Ferredoxin
KM392_RS07455	COG4955	Helix-turn-helix domain
KM392_RS07460	COG0514	ATP-dependent DNA helicase (RecQ)
KM392_RS07465	COG1266	CAAX protease self-immunity
KM392_RS07485	COG4862	establishment of competence for transformation
KM392_RS07490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KM392_RS07510	COG0492	ferredoxin-NADP+ reductase activity
KM392_RS07515	COG0252	asparaginase activity
KM392_RS07585	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM392_RS07600	COG0142	geranyltranstransferase activity
KM392_RS07610	COG0142	geranyltranstransferase activity
KM392_RS07630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM392_RS07635	COG0457	Tetratricopeptide repeat
KM392_RS07655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KM392_RS07665	COG4347	Protein of unknown function (DUF1405)
KM392_RS07680	COG2738	Putative neutral zinc metallopeptidase
KM392_RS07690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM392_RS07695	COG1694	Mazg nucleotide pyrophosphohydrolase
KM392_RS07710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM392_RS07715	COG0438	transferase activity, transferring glycosyl groups
KM392_RS07770	COG3935	DnaD domain protein
KM392_RS07775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KM392_RS07785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM392_RS07785	COG4499	WXG100 protein secretion system (Wss), protein YukC
KM392_RS07845	COG0116	Belongs to the methyltransferase superfamily
KM392_RS07855	COG1199	ATP-dependent helicase activity
KM392_RS07860	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KM392_RS07870	COG3173	Aminoglycoside phosphotransferase
KM392_RS07875	COG0024	Methionine aminopeptidase
KM392_RS07885	COG2233	PERMEase
KM392_RS07890	COG2311	Membrane
KM392_RS07895	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM392_RS07905	COG0456	acetyltransferase
KM392_RS07955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM392_RS07980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KM392_RS07995	COG1215	transferase activity, transferring glycosyl groups
KM392_RS08015	COG0454	-acetyltransferase
KM392_RS08035	COG0328	RNA-DNA hybrid ribonuclease activity
KM392_RS08075	COG1280	lysine exporter protein (LysE YggA)
KM392_RS08090	COG3162	membrane
KM392_RS08095	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM392_RS08100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM392_RS08110	COG0475	glutathione-regulated potassium exporter activity
KM392_RS08115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM392_RS08120	COG0789	Transcriptional regulator
KM392_RS08120	COG4978	Transcriptional regulator
KM392_RS08130	COG2323	membrane
KM392_RS08135	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KM392_RS08190	COG1923	regulation of RNA biosynthetic process
KM392_RS08200	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM392_RS08205	COG1360	Flagellar Motor Protein
KM392_RS08210	COG2201	protein-glutamate methylesterase activity
KM392_RS08220	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM392_RS08220	COG1776	CheC inhibitor of MCP methylation
KM392_RS08235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KM392_RS08255	COG1256	bacterial-type flagellum assembly
KM392_RS08280	COG1815	bacterial-type flagellum-dependent cell motility
KM392_RS08285	COG1558	bacterial-type flagellum-dependent cell motility
KM392_RS08300	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM392_RS08310	COG1157	protein secretion by the type III secretion system
KM392_RS08345	COG0784	Response regulator, receiver
KM392_RS08345	COG0835	chemotaxis
KM392_RS08355	COG0463	Glycosyl transferase, family 2
KM392_RS08380	COG0457	Tetratricopeptide repeat
KM392_RS08380	COG0463	Glycosyl transferase, family 2
KM392_RS08395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KM392_RS08400	COG0741	lytic transglycosylase activity
KM392_RS08415	COG1776	CheC inhibitor of MCP methylation
KM392_RS08415	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM392_RS08425	COG1338	Plays a role in the flagellum-specific transport system
KM392_RS08430	COG1987	bacterial-type flagellum assembly
KM392_RS08440	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM392_RS08445	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM392_RS08450	COG1419	protein localization to endoplasmic reticulum
KM392_RS08455	COG4786	Flagellar basal body rod
KM392_RS08460	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM392_RS08485	COG1309	transcriptional regulator
KM392_RS08505	COG2329	Antibiotic biosynthesis monooxygenase
KM392_RS08535	COG3842	ATPase activity
KM392_RS08540	COG0725	ABC transporter, periplasmic molybdate-binding protein
KM392_RS08550	COG1234	tRNA 3'-trailer cleavage
KM392_RS08575	COG1686	Belongs to the peptidase S11 family
KM392_RS08615	COG0367	asparagine synthase
KM392_RS08645	COG1802	Transcriptional regulator
KM392_RS08650	COG0697	spore germination
KM392_RS08655	COG0523	cobalamin synthesis protein
KM392_RS08660	COG0701	Predicted permease
KM392_RS08670	COG0438	transferase activity, transferring glycosyl groups
KM392_RS08670	COG1216	Glycosyl transferase, family 2
KM392_RS08675	COG1757	Na H antiporter
KM392_RS08680	COG0114	fumarate hydratase activity
KM392_RS08705	COG3340	Belongs to the peptidase S51 family
KM392_RS08725	COG0785	Cytochrome C biogenesis protein
KM392_RS08755	COG2733	membrane
KM392_RS08790	COG1131	(ABC) transporter
KM392_RS08805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM392_RS08810	COG0528	UMP kinase activity
KM392_RS08820	COG1027	Aspartate ammonia-lyase
KM392_RS08825	COG0281	malic enzyme
KM392_RS08830	COG4191	Histidine kinase
KM392_RS08835	COG0784	Response regulator, receiver
KM392_RS08840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM392_RS08900	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM392_RS08910	COG2814	Major facilitator Superfamily
KM392_RS08925	COG1966	Carbon starvation protein
KM392_RS08935	COG0477	Major facilitator Superfamily
KM392_RS08940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM392_RS08950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KM392_RS08980	COG2244	polysaccharide biosynthetic process
KM392_RS08985	COG0733	neurotransmitter:sodium symporter activity
KM392_RS08995	COG5566	PFAM Mor transcription activator
KM392_RS09000	COG2323	membrane
KM392_RS09020	COG2084	Dehydrogenase
KM392_RS09035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM392_RS09045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM392_RS09050	COG0028	Belongs to the TPP enzyme family
KM392_RS09055	COG0440	acetolactate synthase activity
KM392_RS09060	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM392_RS09070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KM392_RS09100	COG3384	dioxygenase
KM392_RS09110	COG3279	Response regulator of the LytR AlgR family
KM392_RS09115	COG0427	acetyl-CoA hydrolase
KM392_RS09135	COG1073	alpha beta
KM392_RS09140	COG4166	transmembrane transport
KM392_RS09165	COG0535	radical SAM domain protein
KM392_RS09170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM392_RS09190	COG1914	H( )-stimulated, divalent metal cation uptake system
KM392_RS09205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KM392_RS09235	COG2390	Transcriptional regulator
KM392_RS09245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM392_RS09250	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KM392_RS09265	COG4224	UPF0291 protein
KM392_RS09285	COG0006	proline dipeptidase activity
KM392_RS09290	COG2132	Multicopper oxidase
KM392_RS09305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM392_RS09320	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM392_RS09335	COG1276	copper resistance
KM392_RS09335	COG2372	response to copper ion
KM392_RS09340	COG4549	nuclear export factor GLE1
KM392_RS09350	COG0697	spore germination
KM392_RS09355	COG0583	DNA-binding transcription factor activity
KM392_RS09360	COG1959	2 iron, 2 sulfur cluster binding
KM392_RS09365	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM392_RS09370	COG0778	Nitroreductase
KM392_RS09380	COG0628	permease
KM392_RS09390	COG1231	oxidoreductase activity
KM392_RS09395	COG0523	cobalamin synthesis protein
KM392_RS09410	COG0318	PFAM AMP-dependent synthetase and ligase
KM392_RS09415	COG2030	dehydratase
KM392_RS09420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM392_RS09430	COG0411	ABC transporter
KM392_RS09450	COG0583	DNA-binding transcription factor activity
KM392_RS09460	COG1942	4-Oxalocrotonate Tautomerase
KM392_RS09470	COG1846	Transcriptional regulator
KM392_RS09480	COG1271	oxidase subunit
KM392_RS09485	COG1294	oxidase, subunit
KM392_RS09490	COG4988	ABC transporter
KM392_RS09495	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KM392_RS09515	COG1686	Belongs to the peptidase S11 family
KM392_RS09530	COG0791	NLP P60 protein
KM392_RS09530	COG1388	LysM domain
KM392_RS09545	COG0745	RESPONSE REGULATOR receiver
KM392_RS09560	COG0300	oxidoreductase activity
KM392_RS09595	COG0460	homoserine dehydrogenase
KM392_RS09620	COG1316	TRANSCRIPTIONal
KM392_RS09630	COG0745	RESPONSE REGULATOR receiver
KM392_RS09635	COG5002	protein histidine kinase activity
KM392_RS09650	COG1285	pathogenesis
KM392_RS09655	COG1247	-acetyltransferase
KM392_RS09675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM392_RS09685	COG1082	Xylose isomerase domain protein TIM barrel
KM392_RS09695	COG2814	Major facilitator Superfamily
KM392_RS09700	COG1279	arginine transmembrane transporter activity
KM392_RS09710	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM392_RS09745	COG0577	efflux transmembrane transporter activity
KM392_RS09750	COG2002	toxin-antitoxin pair type II binding
KM392_RS09755	COG1404	Belongs to the peptidase S8 family
KM392_RS09760	COG0640	Transcriptional regulator
KM392_RS09765	COG0667	Aldo Keto reductase
KM392_RS09770	COG2814	Major facilitator Superfamily
KM392_RS09795	COG0840	transmembrane signaling receptor activity
KM392_RS09810	COG3949	Membrane
KM392_RS09815	COG0783	Belongs to the Dps family
KM392_RS09830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM392_RS09840	COG1231	oxidoreductase activity
KM392_RS09850	COG4989	oxidoreductase activity
KM392_RS09855	COG0523	cobalamin synthesis protein
KM392_RS09860	COG0456	acetyltransferase
KM392_RS09915	COG0803	Belongs to the bacterial solute-binding protein 9 family
KM392_RS09915	COG3443	Belongs to the bacterial solute-binding protein 9 family
KM392_RS09925	COG0702	epimerase
KM392_RS09935	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM392_RS09945	COG4166	transmembrane transport
KM392_RS09960	COG0406	alpha-ribazole phosphatase activity
KM392_RS09970	COG5337	Spore coat protein CotH
KM392_RS09975	COG1051	belongs to the nudix hydrolase family
KM392_RS09980	COG0586	Pfam SNARE associated Golgi protein
KM392_RS09985	COG2244	polysaccharide biosynthetic process
KM392_RS09995	COG0701	Predicted permease
KM392_RS10000	COG3689	TIGRFAM TIGR03943 family protein
KM392_RS10005	COG1607	acyl-coa hydrolase
KM392_RS10015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM392_RS10030	COG0702	epimerase
KM392_RS10035	COG2839	Protein conserved in bacteria
KM392_RS10040	COG1253	flavin adenine dinucleotide binding
KM392_RS10055	COG1114	Component of the transport system for branched-chain amino acids
KM392_RS10060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM392_RS10080	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM392_RS10090	COG1876	peptidase activity
KM392_RS10100	COG0154	amidase activity
KM392_RS10105	COG2211	Major facilitator Superfamily
KM392_RS10125	COG0561	phosphatase activity
KM392_RS10135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KM392_RS10140	COG4106	trans-aconitate 2-methyltransferase activity
KM392_RS10155	COG1819	glycosyl
KM392_RS10160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM392_RS10165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM392_RS10200	COG0456	acetyltransferase
KM392_RS10255	COG3874	Sporulation protein YtfJ
KM392_RS10305	COG0346	lactoylglutathione lyase activity
KM392_RS10315	COG0604	alcohol dehydrogenase
KM392_RS10320	COG1595	DNA-templated transcription, initiation
KM392_RS10345	COG0386	Belongs to the glutathione peroxidase family
KM392_RS10350	COG1305	Transglutaminase-like
KM392_RS10355	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KM392_RS10360	COG0714	Associated with various cellular activities
KM392_RS10375	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KM392_RS10380	COG1140	nitrate reductase beta subunit
KM392_RS10385	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KM392_RS10390	COG2181	nitrate reductase activity
KM392_RS10410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM392_RS10415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KM392_RS10420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM392_RS10425	COG0303	'Molybdopterin
KM392_RS10430	COG0314	molybdopterin synthase activity
KM392_RS10440	COG2223	nitrite transmembrane transporter activity
KM392_RS10455	COG1648	precorrin-2 dehydrogenase activity
KM392_RS10465	COG1587	Uroporphyrinogen-III synthase
KM392_RS10465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KM392_RS10470	COG2146	nitrite reductase [NAD(P)H] activity
KM392_RS10475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM392_RS10480	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
KM392_RS10515	COG2359	stage V sporulation protein S
KM392_RS10540	COG1418	mRNA catabolic process
KM392_RS10545	COG0488	(ABC) transporter
KM392_RS10560	COG0629	single-stranded DNA binding
KM392_RS10575	COG1413	lyase activity
KM392_RS10590	COG2521	methyltransferase
KM392_RS10590	COG2136	Putative SAM-dependent methyltransferase
KM392_RS10595	COG0018	arginyl-trna synthetase
KM392_RS10620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KM392_RS10640	COG0017	Asparaginyl-tRNA synthetase
KM392_RS10660	COG1674	ftsk spoiiie
KM392_RS10730	COG1929	Belongs to the glycerate kinase type-1 family
KM392_RS10735	COG0471	metal ion transport
KM392_RS10740	COG0745	RESPONSE REGULATOR receiver
KM392_RS10745	COG3850	Histidine kinase
KM392_RS10745	COG5002	protein histidine kinase activity
KM392_RS10760	COG0733	neurotransmitter:sodium symporter activity
KM392_RS10785	COG2610	gluconate transmembrane transporter activity
KM392_RS10790	COG1454	alcohol dehydrogenase
KM392_RS10795	COG1794	racemase activity, acting on amino acids and derivatives
KM392_RS10805	COG0456	acetyltransferase
KM392_RS10820	COG1131	(ABC) transporter
KM392_RS10835	COG0546	phosphoglycolate phosphatase activity
KM392_RS10855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM392_RS10870	COG0768	penicillin binding
KM392_RS10875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM392_RS10880	COG0204	Acyl-transferase
KM392_RS10885	COG1272	protein, Hemolysin III
KM392_RS10895	COG0805	protein transport
KM392_RS10905	COG1307	EDD domain protein, DegV family
KM392_RS10910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KM392_RS10915	COG1999	signal sequence binding
KM392_RS10920	COG0071	Belongs to the small heat shock protein (HSP20) family
KM392_RS10925	COG0367	asparagine synthase
KM392_RS10945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM392_RS10950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM392_RS10985	COG0668	transmembrane transport
KM392_RS10990	COG2203	Gaf domain
KM392_RS10990	COG4585	Histidine kinase
KM392_RS10995	COG2197	response regulator
KM392_RS11005	COG1064	alcohol dehydrogenase
KM392_RS11060	COG0517	IMP dehydrogenase activity
KM392_RS11060	COG1125	glycine betaine transport
KM392_RS11065	COG1174	glycine betaine transport
KM392_RS11100	COG1253	flavin adenine dinucleotide binding
KM392_RS11105	COG1012	belongs to the aldehyde dehydrogenase family
KM392_RS11110	COG5506	Protein of unknown function (DUF1694)
KM392_RS11125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM392_RS11130	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KM392_RS11135	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KM392_RS11140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM392_RS11145	COG0456	acetyltransferase
KM392_RS11150	COG3829	transcription factor binding
KM392_RS11155	COG1509	lysine 2,3-aminomutase activity
KM392_RS11195	COG4326	sporulation control protein
KM392_RS11200	COG0671	phosphoesterase, PA-phosphatase related
KM392_RS11205	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KM392_RS11210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM392_RS11240	COG1787	Restriction endonuclease
KM392_RS11240	COG1715	Restriction endonuclease
KM392_RS11330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM392_RS11370	COG4499	WXG100 protein secretion system (Wss), protein YukC
KM392_RS11370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM392_RS11380	COG2814	Major facilitator Superfamily
KM392_RS11385	COG4841	protein insertion into membrane
KM392_RS11390	COG0372	Belongs to the citrate synthase family
KM392_RS11395	COG2079	MmgE PrpD family protein
KM392_RS11400	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KM392_RS11405	COG1960	acyl-CoA dehydrogenase activity
KM392_RS11410	COG2084	Dehydrogenase
KM392_RS11420	COG1280	lysine exporter protein (LysE YggA)
KM392_RS11425	COG1024	Enoyl-CoA hydratase
KM392_RS11440	COG0420	3'-5' exonuclease activity
KM392_RS11445	COG0419	ATPase involved in DNA repair
KM392_RS11470	COG2223	nitrite transmembrane transporter activity
KM392_RS11475	COG1028	Short-chain dehydrogenase reductase Sdr
KM392_RS11480	COG1169	isochorismate synthase
KM392_RS11485	COG1021	2,3-dihydroxybenzoate-AMP ligase
KM392_RS11490	COG1535	isochorismatase
KM392_RS11490	COG3433	isochorismatase activity
KM392_RS11500	COG3251	PFAM MbtH domain protein
KM392_RS11505	COG2814	Major facilitator Superfamily
KM392_RS11520	COG0776	regulation of translation
KM392_RS11530	COG2318	DinB family
KM392_RS11555	COG2329	Antibiotic biosynthesis monooxygenase
KM392_RS11560	COG1187	pseudouridine synthase activity
KM392_RS11565	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM392_RS11580	COG0596	Alpha beta hydrolase
KM392_RS11585	COG2814	Major facilitator Superfamily
KM392_RS11605	COG2226	methyltransferase
KM392_RS11650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM392_RS11685	COG1247	-acetyltransferase
KM392_RS11715	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KM392_RS11725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM392_RS11735	COG1278	Cold shock
KM392_RS11750	COG0010	Belongs to the arginase family
KM392_RS11755	COG0561	phosphatase activity
KM392_RS11800	COG0583	DNA-binding transcription factor activity
KM392_RS11805	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KM392_RS11820	COG0583	DNA-binding transcription factor activity
KM392_RS11825	COG2258	MOSC domain
KM392_RS11840	COG1132	(ABC) transporter
KM392_RS11845	COG1132	(ABC) transporter
KM392_RS11865	COG1396	sequence-specific DNA binding
KM392_RS11890	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
KM392_RS11895	COG1595	DNA-templated transcription, initiation
KM392_RS11920	COG1649	PFAM Uncharacterised BCR, COG1649
KM392_RS11945	COG2971	BadF BadG BcrA BcrD
KM392_RS11950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM392_RS11955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KM392_RS11975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM392_RS12005	COG1309	transcriptional regulator
KM392_RS12020	COG0577	efflux transmembrane transporter activity
KM392_RS12020	COG1136	(ABC) transporter
KM392_RS12025	COG0500	methyltransferase
KM392_RS12025	COG3615	Tellurite resistance protein tehB
KM392_RS12035	COG2226	methyltransferase
KM392_RS12040	COG3961	Belongs to the TPP enzyme family
KM392_RS12045	COG1846	Transcriptional regulator
KM392_RS12085	COG2195	Cleaves the N-terminal amino acid of tripeptides
KM392_RS12100	COG1595	DNA-templated transcription, initiation
KM392_RS12110	COG0768	penicillin binding
KM392_RS12115	COG0768	penicillin binding
KM392_RS12120	COG2367	Beta-lactamase
KM392_RS12125	COG0671	phosphoesterase, PA-phosphatase related
KM392_RS12130	COG1609	Transcriptional regulator
KM392_RS12135	COG2814	Major facilitator Superfamily
KM392_RS12140	COG0673	inositol 2-dehydrogenase activity
KM392_RS12150	COG1012	belongs to the aldehyde dehydrogenase family
KM392_RS12165	COG0191	fructose-bisphosphate aldolase activity
KM392_RS12185	COG0737	Belongs to the 5'-nucleotidase family
KM392_RS12200	COG1476	TRANSCRIPTIONal
KM392_RS12215	COG1876	peptidase activity
KM392_RS12235	COG1309	transcriptional regulator
KM392_RS12240	COG0488	(ABC) transporter
KM392_RS12255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM392_RS12275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM392_RS12290	COG1131	(ABC) transporter
KM392_RS12300	COG1309	transcriptional regulator
KM392_RS12315	COG1960	acyl-CoA dehydrogenase activity
KM392_RS12320	COG0439	Biotin carboxylase
KM392_RS12325	COG0511	ligase activity, forming carbon-carbon bonds
KM392_RS12330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KM392_RS12335	COG1024	Enoyl-CoA hydratase
KM392_RS12340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KM392_RS12345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM392_RS12355	COG1247	-acetyltransferase
KM392_RS12360	COG0572	uridine kinase
KM392_RS12370	COG2318	DinB family
KM392_RS12375	COG1686	Belongs to the peptidase S11 family
KM392_RS12400	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KM392_RS12440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM392_RS12440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM392_RS12465	COG2814	Major facilitator Superfamily
KM392_RS12480	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM392_RS12500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM392_RS12515	COG1063	alcohol dehydrogenase
KM392_RS12530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KM392_RS12535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KM392_RS12550	COG3773	Cell wall hydrolase
KM392_RS12560	COG0745	RESPONSE REGULATOR receiver
KM392_RS12575	COG0488	(ABC) transporter
KM392_RS12590	COG1136	(ABC) transporter
KM392_RS12615	COG0460	homoserine dehydrogenase
KM392_RS12620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM392_RS12630	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KM392_RS12700	COG2124	cytochrome p450
KM392_RS12735	COG0561	phosphatase activity
KM392_RS12745	COG0768	penicillin binding
KM392_RS12750	COG1819	glycosyl
KM392_RS12755	COG1794	racemase activity, acting on amino acids and derivatives
KM392_RS12765	COG1122	ATPase activity
KM392_RS12780	COG2205	protein histidine kinase activity
KM392_RS12790	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM392_RS12795	COG0604	alcohol dehydrogenase
KM392_RS12800	COG0768	penicillin binding
KM392_RS12810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM392_RS12845	COG0693	protein deglycase activity
KM392_RS12875	COG2814	Major facilitator Superfamily
KM392_RS12890	COG0584	glycerophosphoryl diester phosphodiesterase
KM392_RS12910	COG0697	spore germination
KM392_RS12940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM392_RS12950	COG2223	nitrite transmembrane transporter activity
KM392_RS12965	COG2816	NAD+ diphosphatase activity
KM392_RS12970	COG0592	DNA-directed DNA polymerase activity
KM392_RS12975	COG1051	belongs to the nudix hydrolase family
KM392_RS13010	COG3878	Protein conserved in bacteria
KM392_RS13060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KM392_RS13075	COG0322	excinuclease ABC activity
KM392_RS13120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM392_RS13145	COG1011	Hydrolase
KM392_RS13160	COG0657	acetylesterase activity
KM392_RS13165	COG0076	glutamate decarboxylase activity
KM392_RS13180	COG1523	belongs to the glycosyl hydrolase 13 family
KM392_RS13185	COG3227	Zinc metalloprotease (Elastase)
KM392_RS13205	COG0201	protein transport
KM392_RS13215	COG0697	spore germination
KM392_RS13220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM392_RS13250	COG4129	membrane
KM392_RS13255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM392_RS13270	COG2959	enzyme of heme biosynthesis
KM392_RS13290	COG3483	tryptophan 2,3-dioxygenase activity
KM392_RS13295	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KM392_RS13300	COG3844	kynureninase activity
KM392_RS13305	COG1309	transcriptional regulator
KM392_RS13335	COG3284	Transcriptional regulator
KM392_RS13355	COG1349	DNA-binding transcription factor activity
KM392_RS13375	COG1959	2 iron, 2 sulfur cluster binding
KM392_RS13390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM392_RS13395	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM392_RS13400	COG0022	dehydrogenase e1 component
KM392_RS13405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM392_RS13415	COG1028	Short-chain dehydrogenase reductase Sdr
KM392_RS13420	COG0456	acetyltransferase
KM392_RS13420	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM392_RS13450	COG4176	ABC-type proline glycine betaine transport system permease component
KM392_RS13455	COG4175	Glycine betaine
KM392_RS13455	COG0517	IMP dehydrogenase activity
KM392_RS13480	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KM392_RS13485	COG2153	protein acetylation
KM392_RS13490	COG3397	chitin binding
KM392_RS13505	COG2205	protein histidine kinase activity
KM392_RS13530	COG2333	competence protein COMEC
KM392_RS13530	COG0658	competence protein
KM392_RS13580	COG3973	AAA domain
KM392_RS13595	COG2105	PFAM AIG2 family protein
KM392_RS13600	COG0514	ATP-dependent DNA helicase (RecQ)
KM392_RS13620	COG4637	Psort location Cytoplasmic, score
KM392_RS13645	COG3397	chitin binding
KM392_RS13660	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KM392_RS13665	COG1115	amino acid carrier protein
KM392_RS13670	COG1012	belongs to the aldehyde dehydrogenase family
KM392_RS13675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KM392_RS13685	COG3938	Belongs to the proline racemase family
KM392_RS13690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM392_RS13730	COG0586	Pfam SNARE associated Golgi protein
KM392_RS13745	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KM392_RS13750	COG0519	Catalyzes the synthesis of GMP from XMP
KM392_RS13755	COG4166	transmembrane transport
KM392_RS13765	COG4948	Mandelate Racemase Muconate Lactonizing
KM392_RS13810	COG2936	dipeptidyl-peptidase activity
KM392_RS13815	COG5002	protein histidine kinase activity
KM392_RS13820	COG0745	RESPONSE REGULATOR receiver
KM392_RS13865	COG1307	EDD domain protein, DegV family
KM392_RS13885	COG2814	Major facilitator Superfamily
KM392_RS13895	COG1664	Polymer-forming cytoskeletal
KM392_RS13900	COG0789	Transcriptional regulator
KM392_RS13905	COG4533	DNA binding
KM392_RS13910	COG0477	Major facilitator Superfamily
KM392_RS13910	COG2814	Major facilitator Superfamily
KM392_RS13930	COG2261	transglycosylase associated protein
KM392_RS13945	COG2226	methyltransferase
KM392_RS13980	COG0436	Aminotransferase
KM392_RS13985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KM392_RS13990	COG5146	pantothenate kinase activity
KM392_RS14010	COG1131	(ABC) transporter
KM392_RS14055	COG0628	permease
KM392_RS14070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM392_RS14075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM392_RS14080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM392_RS14085	COG1116	anion transmembrane transporter activity
KM392_RS14105	COG2816	NAD+ diphosphatase activity
KM392_RS14125	COG2746	aminoglycoside 3-N-acetyltransferase activity
KM392_RS14150	COG0697	spore germination
KM392_RS14155	COG2318	DinB family
KM392_RS14195	COG0861	Integral membrane protein TerC family
KM392_RS14200	COG1368	sulfuric ester hydrolase activity
KM392_RS14205	COG0488	(ABC) transporter
KM392_RS14220	COG1309	transcriptional regulator
KM392_RS14235	COG0287	Prephenate dehydrogenase
KM392_RS14240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM392_RS14245	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KM392_RS14250	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KM392_RS14250	COG1605	Chorismate mutase
KM392_RS14285	COG1388	LysM domain
KM392_RS14285	COG3584	3D domain protein
KM392_RS14295	COG1595	DNA-templated transcription, initiation
KM392_RS14320	COG1879	ABC-type sugar transport system periplasmic component
KM392_RS14330	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM392_RS14340	COG2390	Transcriptional regulator
KM392_RS14345	COG1070	Carbohydrate kinase
KM392_RS14375	COG2329	Antibiotic biosynthesis monooxygenase
KM392_RS14395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM392_RS14405	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KM392_RS14410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM392_RS14415	COG4187	Peptidase family M20/M25/M40
KM392_RS14420	COG1414	Transcriptional regulator
KM392_RS14425	COG0833	amino acid
KM392_RS14430	COG1690	Belongs to the RtcB family
KM392_RS14435	COG3239	Fatty acid desaturase
KM392_RS14440	COG1785	Belongs to the alkaline phosphatase family
KM392_RS14450	COG3655	Transcriptional regulator
KM392_RS14465	COG4377	Putative membrane peptidase family (DUF2324)
KM392_RS14475	COG3279	Response regulator of the LytR AlgR family
KM392_RS14485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM392_RS14490	COG0346	lactoylglutathione lyase activity
KM392_RS14510	COG0714	Associated with various cellular activities
KM392_RS14555	COG0463	Glycosyl transferase, family 2
KM392_RS14565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM392_RS14570	COG0753	catalase activity
KM392_RS14580	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KM392_RS14605	COG0714	Associated with various cellular activities
KM392_RS14615	COG0778	Nitroreductase
KM392_RS14620	COG1846	Transcriptional regulator
KM392_RS14655	COG1725	Transcriptional regulator
KM392_RS14665	COG0577	efflux transmembrane transporter activity
KM392_RS14665	COG1136	(ABC) transporter
KM392_RS14690	COG2207	Transcriptional regulator
KM392_RS14695	COG0456	acetyltransferase
KM392_RS14715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM392_RS14735	COG0642	Histidine kinase
KM392_RS14740	COG0745	RESPONSE REGULATOR receiver
KM392_RS14745	COG0596	Alpha beta hydrolase
KM392_RS14775	COG0730	response to heat
KM392_RS14785	COG0833	amino acid
KM392_RS14795	COG4335	DNA alkylation repair
KM392_RS14835	COG0768	penicillin binding
KM392_RS14845	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KM392_RS14880	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KM392_RS14885	COG1414	Transcriptional regulator
KM392_RS14900	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM392_RS14905	COG0640	Transcriptional regulator
KM392_RS14915	COG1960	acyl-CoA dehydrogenase activity
KM392_RS14930	COG3314	Sporulation integral membrane protein YlbJ
KM392_RS14945	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KM392_RS14960	COG0574	Belongs to the PEP-utilizing enzyme family
KM392_RS14960	COG3848	Pyruvate phosphate dikinase
KM392_RS14965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM392_RS14980	COG5577	PFAM Coat F domain
KM392_RS14985	COG3403	YqcI/YcgG family
KM392_RS14990	COG1280	lysine exporter protein (LysE YggA)
KM392_RS15025	COG1063	alcohol dehydrogenase
KM392_RS15040	COG1027	Aspartate ammonia-lyase
KM392_RS15045	COG0252	asparaginase activity
KM392_RS15050	COG1396	sequence-specific DNA binding
KM392_RS15060	COG0322	excinuclease ABC activity
KM392_RS15065	COG0531	amino acid
KM392_RS15070	COG1114	Component of the transport system for branched-chain amino acids
KM392_RS15075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM392_RS15085	COG0281	malic enzyme
KM392_RS15100	COG0531	amino acid
KM392_RS15110	COG0784	Response regulator, receiver
KM392_RS15120	COG2066	Belongs to the glutaminase family
KM392_RS15125	COG1115	amino acid carrier protein
KM392_RS15155	COG0737	Belongs to the 5'-nucleotidase family
KM392_RS15160	COG0753	catalase activity
KM392_RS15165	COG2267	carboxylic ester hydrolase activity
KM392_RS15170	COG1335	isochorismatase
KM392_RS15190	COG0583	DNA-binding transcription factor activity
KM392_RS15200	COG0598	Magnesium transport protein CorA
KM392_RS15240	COG0415	Belongs to the DNA photolyase family
KM392_RS15245	COG0288	reversible hydration of carbon dioxide
KM392_RS15255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM392_RS15260	COG5609	conserved protein (DUF2294)
KM392_RS15275	COG1575	Belongs to the MenA family. Type 1 subfamily
KM392_RS15280	COG2267	carboxylic ester hydrolase activity
KM392_RS15285	COG0803	Belongs to the bacterial solute-binding protein 9 family
KM392_RS15290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KM392_RS15295	COG1121	(ABC) transporter
KM392_RS15325	COG0798	PFAM Bile acid sodium symporter
KM392_RS15330	COG0346	lactoylglutathione lyase activity
KM392_RS15335	COG0640	Transcriptional regulator
KM392_RS15350	COG0443	Heat shock 70 kDa protein
KM392_RS15365	COG1522	sequence-specific DNA binding
KM392_RS15380	COG0346	lactoylglutathione lyase activity
KM392_RS15400	COG2169	Transcriptional regulator
KM392_RS15445	COG2814	Major facilitator Superfamily
KM392_RS15470	COG0745	RESPONSE REGULATOR receiver
KM392_RS15475	COG3850	Histidine kinase
KM392_RS15475	COG5002	protein histidine kinase activity
KM392_RS15500	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KM392_RS15520	COG1476	TRANSCRIPTIONal
KM392_RS15535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM392_RS15540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM392_RS15550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM392_RS15555	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KM392_RS15570	COG1136	(ABC) transporter
KM392_RS15575	COG0577	efflux transmembrane transporter activity
KM392_RS15590	COG3850	Histidine kinase
KM392_RS15590	COG5002	protein histidine kinase activity
KM392_RS15600	COG2364	Membrane
KM392_RS15605	COG1846	Transcriptional regulator
KM392_RS15615	COG2808	Putative FMN-binding domain
KM392_RS15620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM392_RS15625	COG2271	Major facilitator Superfamily
KM392_RS15630	COG1556	Lactate utilization protein
KM392_RS15635	COG1139	Iron-sulfur cluster binding protein
KM392_RS15645	COG0583	DNA-binding transcription factor activity
KM392_RS15655	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM392_RS15685	COG0673	inositol 2-dehydrogenase activity
KM392_RS15690	COG0561	phosphatase activity
KM392_RS15700	COG1609	Transcriptional regulator
KM392_RS15705	COG0457	Tetratricopeptide repeat
KM392_RS15725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM392_RS15755	COG0534	Mate efflux family protein
KM392_RS15775	COG2814	Major facilitator Superfamily
KM392_RS15780	COG1309	transcriptional regulator
KM392_RS15795	COG0814	amino acid
KM392_RS15800	COG1760	l-serine dehydratase
KM392_RS15805	COG1760	l-serine dehydratase
KM392_RS15815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM392_RS15820	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KM392_RS15835	COG1522	sequence-specific DNA binding
KM392_RS15840	COG0531	amino acid
KM392_RS15860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KM392_RS15880	COG1595	DNA-templated transcription, initiation
KM392_RS15895	COG0662	Cupin 2, conserved barrel domain protein
KM392_RS15900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM392_RS15900	COG2207	Transcriptional regulator
KM392_RS15950	COG0477	Major facilitator Superfamily
KM392_RS15960	COG1846	Transcriptional regulator
KM392_RS15965	COG2814	Major facilitator Superfamily
KM392_RS15975	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM392_RS15980	COG1131	(ABC) transporter
KM392_RS16000	COG2076	Multidrug Resistance protein
KM392_RS16005	COG1309	transcriptional regulator
KM392_RS16015	COG2031	fatty acid transporter
KM392_RS16025	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM392_RS16055	COG1122	ATPase activity
KM392_RS16060	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KM392_RS16075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KM392_RS16080	COG1288	antiporter activity
KM392_RS16085	COG2356	endonuclease I
KM392_RS16100	COG3620	sequence-specific DNA binding
KM392_RS16105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM392_RS16110	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KM392_RS16115	COG0124	histidyl-tRNA synthetase
KM392_RS16130	COG1733	regulation of RNA biosynthetic process
KM392_RS16135	COG0778	Nitroreductase
KM392_RS16155	COG1028	Short-chain dehydrogenase reductase Sdr
KM392_RS16165	COG1131	(ABC) transporter
KM392_RS16190	COG1011	Hydrolase
KM392_RS16200	COG2365	Tyrosine phosphatase family
KM392_RS16225	COG0346	lactoylglutathione lyase activity
KM392_RS16230	COG1940	carbohydrate kinase activity
KM392_RS16235	COG0738	Major facilitator superfamily
KM392_RS16240	COG0110	maltose O-acetyltransferase activity
KM392_RS16250	COG1136	(ABC) transporter
KM392_RS16250	COG0577	efflux transmembrane transporter activity
KM392_RS16265	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KM392_RS16270	COG0628	permease
KM392_RS16290	COG2226	methyltransferase
KM392_RS16300	COG0477	Major facilitator Superfamily
KM392_RS16330	COG1253	flavin adenine dinucleotide binding
KM392_RS16335	COG0789	Transcriptional regulator
KM392_RS16340	COG0697	spore germination
KM392_RS16345	COG1357	PFAM Pentapeptide repeats (8 copies)
KM392_RS16350	COG3813	Protein conserved in bacteria
KM392_RS16355	COG2706	6-phosphogluconolactonase activity
KM392_RS16360	COG1070	Carbohydrate kinase
KM392_RS16370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KM392_RS16375	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KM392_RS16390	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM392_RS16395	COG0604	alcohol dehydrogenase
KM392_RS16400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM392_RS16410	COG0604	alcohol dehydrogenase
KM392_RS16410	COG3321	synthase
KM392_RS16415	COG1028	Short-chain dehydrogenase reductase Sdr
KM392_RS16440	COG0656	L-ascorbic acid biosynthetic process
KM392_RS16445	COG2814	Major facilitator Superfamily
KM392_RS16460	COG0346	lactoylglutathione lyase activity
KM392_RS16465	COG0814	amino acid
KM392_RS16490	COG1393	Belongs to the ArsC family
KM392_RS16495	COG1733	regulation of RNA biosynthetic process
KM392_RS16500	COG2188	Transcriptional regulator
KM392_RS16505	COG0673	inositol 2-dehydrogenase activity
KM392_RS16510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KM392_RS16515	COG1733	regulation of RNA biosynthetic process
KM392_RS16520	COG1733	regulation of RNA biosynthetic process
KM392_RS16535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM392_RS16555	COG0384	phenazine biosynthesis protein PhzF
KM392_RS16565	COG1028	Short-chain dehydrogenase reductase Sdr
KM392_RS16575	COG0318	PFAM AMP-dependent synthetase and ligase
KM392_RS16585	COG1733	regulation of RNA biosynthetic process
KM392_RS16615	COG1191	sigma factor activity
KM392_RS16630	COG1309	transcriptional regulator
KM392_RS16650	COG3152	Membrane
KM392_RS16675	COG1151	hydroxylamine reductase activity
KM392_RS16685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM392_RS16690	COG3757	hydrolase, family 25
KM392_RS16690	COG3409	Peptidoglycan-binding domain 1 protein
KM392_RS16725	COG2072	flavoprotein involved in K transport
KM392_RS16760	COG0604	alcohol dehydrogenase
KM392_RS16765	COG1113	amino acid transport
KM392_RS16770	COG2814	Major facilitator Superfamily
KM392_RS16800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM392_RS16805	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM392_RS16830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM392_RS16835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM392_RS16840	COG3739	integral membrane protein
KM392_RS16845	COG0384	phenazine biosynthesis protein PhzF
KM392_RS16875	COG0583	DNA-binding transcription factor activity
KM392_RS16895	COG1193	negative regulation of DNA recombination
KM392_RS16910	COG2162	N-hydroxyarylamine O-acetyltransferase activity
KM392_RS16915	COG1164	Oligoendopeptidase f
KM392_RS16920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM392_RS16950	COG0584	glycerophosphoryl diester phosphodiesterase
KM392_RS16975	COG0640	Transcriptional regulator
KM392_RS16980	COG0604	alcohol dehydrogenase
KM392_RS17000	COG2808	Putative FMN-binding domain
KM392_RS17015	COG0385	Bile acid
KM392_RS17020	COG0277	FAD linked oxidase domain protein
KM392_RS17050	COG1216	Glycosyl transferase, family 2
KM392_RS17055	COG1024	Enoyl-CoA hydratase
KM392_RS17065	COG1285	pathogenesis
KM392_RS17080	COG2514	catechol 2,3-dioxygenase activity
KM392_RS17085	COG2720	vancomycin resistance protein
KM392_RS17125	COG0716	FMN binding
KM392_RS17155	COG1028	Short-chain dehydrogenase reductase Sdr
KM392_RS17180	COG4145	pantothenate transmembrane transporter activity
KM392_RS17190	COG1012	belongs to the aldehyde dehydrogenase family
KM392_RS17195	COG1028	Short-chain dehydrogenase reductase Sdr
KM392_RS17205	COG1657	PFAM Prenyltransferase squalene oxidase
KM392_RS17210	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KM392_RS17215	COG2962	Rard protein
KM392_RS17220	COG3326	Membrane
KM392_RS17235	COG0489	protein tyrosine kinase activity
KM392_RS17245	COG0314	molybdopterin synthase activity
KM392_RS17250	COG0303	'Molybdopterin
KM392_RS17255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM392_RS17260	COG2116	formate transmembrane transporter activity
KM392_RS17270	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KM392_RS17275	COG5609	conserved protein (DUF2294)
KM392_RS17280	COG2427	Protein of unknown function (DUF1641)
KM392_RS17295	COG0697	spore germination
KM392_RS17335	COG2226	methyltransferase
KM392_RS17340	COG4166	transmembrane transport
KM392_RS17345	COG4166	transmembrane transport
KM392_RS17350	COG1301	dicarboxylic acid transport
KM392_RS17355	COG1316	TRANSCRIPTIONal
KM392_RS17365	COG1595	DNA-templated transcription, initiation
KM392_RS17385	COG1131	(ABC) transporter
KM392_RS17395	COG0673	inositol 2-dehydrogenase activity
KM392_RS17400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KM392_RS17405	COG0187	DNA topoisomerase II activity
KM392_RS17410	COG1832	CoA-binding protein
KM392_RS17415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM392_RS17420	COG0745	RESPONSE REGULATOR receiver
KM392_RS17435	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM392_RS17440	COG4841	protein insertion into membrane
KM392_RS17445	COG0824	Thioesterase
KM392_RS17475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM392_RS17485	COG2274	protein secretion by the type I secretion system
KM392_RS17490	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KM392_RS17530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM392_RS17545	COG0183	Belongs to the thiolase family
KM392_RS17550	COG0318	PFAM AMP-dependent synthetase and ligase
KM392_RS17555	COG1268	BioY protein
KM392_RS17560	COG0318	PFAM AMP-dependent synthetase and ligase
KM392_RS17610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM392_RS17620	COG5002	protein histidine kinase activity
KM392_RS17625	COG0400	carboxylic ester hydrolase activity
KM392_RS17630	COG0346	lactoylglutathione lyase activity
KM392_RS17635	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM392_RS17640	COG0069	glutamate synthase activity
KM392_RS17645	COG1902	pentaerythritol trinitrate reductase activity
KM392_RS17650	COG1329	Transcriptional regulator
KM392_RS17655	COG0010	Belongs to the arginase family
KM392_RS17680	COG2226	methyltransferase
KM392_RS17715	COG4846	Membrane protein involved in cytochrome C biogenesis
KM392_RS17720	COG0785	Cytochrome C biogenesis protein
KM392_RS17730	COG0583	DNA-binding transcription factor activity
KM392_RS17735	COG1380	Effector of murein hydrolase LrgA
KM392_RS17740	COG1346	cytolysis
KM392_RS17765	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM392_RS17765	COG3409	Peptidoglycan-binding domain 1 protein
KM392_RS17780	COG1132	(ABC) transporter
KM392_RS17785	COG1132	(ABC) transporter
KM392_RS17815	COG3639	organic phosphonate transmembrane transporter activity
KM392_RS17820	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KM392_RS17840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KM392_RS17860	COG1695	Transcriptional regulator
KM392_RS17900	COG3409	Peptidoglycan-binding domain 1 protein
KM392_RS17900	COG1388	LysM domain
KM392_RS17900	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM392_RS17905	COG4824	toxin secretion phage lysis holin
KM392_RS18050	COG1595	DNA-templated transcription, initiation
KM392_RS18095	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
KM392_RS18180	COG1396	sequence-specific DNA binding
KM392_RS18205	COG0174	glutamine synthetase
KM392_RS18210	COG0789	Transcriptional regulator
KM392_RS18215	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KM392_RS18220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KM392_RS18225	COG2860	membrane
KM392_RS18230	COG0464	growth
KM392_RS18260	COG3584	3D domain protein
KM392_RS18260	COG1388	LysM domain
KM392_RS18265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM392_RS18265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM392_RS18265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM392_RS18270	COG1105	Belongs to the carbohydrate kinase PfkB family
KM392_RS18275	COG1349	DNA-binding transcription factor activity
KM392_RS18285	COG2322	membrane
KM392_RS18295	COG1113	amino acid transport
KM392_RS18310	COG1408	metallophosphoesterase
KM392_RS18315	COG2116	formate transmembrane transporter activity
KM392_RS18325	COG2217	Heavy metal translocating P-type atpase
KM392_RS18330	COG2608	mercury ion transmembrane transporter activity
KM392_RS18335	COG1937	Protein conserved in bacteria
KM392_RS18345	COG2819	hydrolase of the alpha beta superfamily
KM392_RS18350	COG1120	ATPase activity
KM392_RS18355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM392_RS18360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM392_RS18375	COG2169	Transcriptional regulator
KM392_RS18380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM392_RS18385	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KM392_RS18395	COG2364	Membrane
KM392_RS18410	COG2267	carboxylic ester hydrolase activity
KM392_RS18415	COG0346	lactoylglutathione lyase activity
KM392_RS18440	COG1346	cytolysis
KM392_RS18445	COG1380	Effector of murein hydrolase LrgA
KM392_RS18450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM392_RS18455	COG0596	Alpha beta hydrolase
KM392_RS18455	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM392_RS18460	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM392_RS18480	COG1404	Belongs to the peptidase S8 family
KM392_RS18485	COG3773	Cell wall hydrolase
KM392_RS18490	COG0562	UDP-galactopyranose mutase
KM392_RS18495	COG1368	sulfuric ester hydrolase activity
KM392_RS18500	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM392_RS18510	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KM392_RS18535	COG1131	(ABC) transporter
KM392_RS18555	COG4550	Control of competence regulator ComK, YlbF/YmcA
KM392_RS18560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KM392_RS18565	COG1013	pyruvate-flavodoxin oxidoreductase activity
KM392_RS18570	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KM392_RS18570	COG0674	pyruvate-flavodoxin oxidoreductase activity
KM392_RS18580	COG2359	stage V sporulation protein S
KM392_RS18585	COG1692	metallophosphoesterase
KM392_RS18610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KM392_RS18615	COG1426	Protein conserved in bacteria
KM392_RS18630	COG0300	oxidoreductase activity
KM392_RS18635	COG0612	Peptidase, M16
KM392_RS18640	COG0612	Peptidase, M16
KM392_RS18655	COG3845	ABC transporter
KM392_RS18660	COG1744	ABC transporter substrate-binding protein PnrA-like
KM392_RS18665	COG2188	Transcriptional regulator
KM392_RS18670	COG1674	ftsk spoiiie
KM392_RS18680	COG0740	serine-type endopeptidase activity
KM392_RS18685	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM392_RS18695	COG0527	aspartate kinase activity
KM392_RS18700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KM392_RS18705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM392_RS18710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KM392_RS18715	COG1873	PFAM PRC-barrel domain
KM392_RS18720	COG0612	Peptidase, M16
KM392_RS18725	COG0726	polysaccharide deacetylase
KM392_RS18740	COG0196	riboflavin kinase activity
KM392_RS18745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KM392_RS18755	COG1550	Protein conserved in bacteria
KM392_RS18765	COG1358	cellular component organization or biogenesis
KM392_RS18770	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KM392_RS18775	COG0195	Participates in both transcription termination and antitermination
KM392_RS18795	COG0750	zinc metalloprotease
KM392_RS18805	COG4589	Belongs to the CDS family
KM392_RS18820	COG0528	UMP kinase activity
KM392_RS18850	COG4974	Belongs to the 'phage' integrase family
KM392_RS18860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM392_RS18870	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KM392_RS18910	COG1837	Belongs to the UPF0109 family
KM392_RS18920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KM392_RS18930	COG0552	protein localization to endoplasmic reticulum
KM392_RS18935	COG1196	nuclear chromosome segregation
KM392_RS18945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM392_RS18950	COG1028	Short-chain dehydrogenase reductase Sdr
KM392_RS18955	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KM392_RS18970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KM392_RS18975	COG1461	Dihydroxyacetone kinase
KM392_RS18980	COG1302	Protein conserved in bacteria
KM392_RS18995	COG1564	THIamine pyrophosphokinase
KM392_RS19000	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KM392_RS19005	COG1162	GTPase activity
KM392_RS19010	COG2815	serine threonine protein kinase
KM392_RS19010	COG0515	serine threonine protein kinase
KM392_RS19015	COG0631	protein serine/threonine phosphatase activity
KM392_RS19025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KM392_RS19025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KM392_RS19035	COG0242	peptide deformylase activity
KM392_RS19040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KM392_RS19045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM392_RS19065	COG1561	YicC-like family, N-terminal region
KM392_RS19070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KM392_RS19080	COG0006	proline dipeptidase activity
KM392_RS19095	COG3069	C4-dicarboxylate transmembrane transporter activity
KM392_RS19160	COG0564	pseudouridine synthase activity
KM392_RS19180	COG3599	regulation of cell shape
KM392_RS19185	COG2302	S4 RNA-binding domain
KM392_RS19190	COG0762	integral membrane protein
KM392_RS19200	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KM392_RS19205	COG1496	oxidoreductase activity
KM392_RS19210	COG1873	PFAM PRC-barrel domain
KM392_RS19215	COG1191	sigma factor activity
KM392_RS19220	COG1191	sigma factor activity
KM392_RS19230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KM392_RS19235	COG0849	cell division
KM392_RS19240	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KM392_RS19245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM392_RS19255	COG0772	Belongs to the SEDS family
KM392_RS19270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KM392_RS19275	COG0768	penicillin binding
KM392_RS19280	COG0768	penicillin binding
KM392_RS19285	COG4839	cell division protein FtsL
KM392_RS19300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KM392_RS19315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KM392_RS19320	COG1399	metal-binding, possibly nucleic acid-binding protein
KM392_RS19370	COG4824	toxin secretion phage lysis holin
KM392_RS19460	COG1802	Transcriptional regulator
KM392_RS19460	COG4626	Terminase
KM392_RS19485	COG0582	viral genome integration into host DNA
KM392_RS19550	COG0756	dUTP diphosphatase activity
KM392_RS19570	COG1191	sigma factor activity
KM392_RS19595	COG1484	DNA-dependent DNA replication
KM392_RS19620	COG1396	sequence-specific DNA binding
KM392_RS19635	COG1396	sequence-specific DNA binding
KM392_RS19650	COG0582	viral genome integration into host DNA
KM392_RS19660	COG3480	Lon protease (S16) C-terminal proteolytic domain
KM392_RS19665	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM392_RS19670	COG3314	Sporulation integral membrane protein YlbJ
KM392_RS19680	COG0742	ribosomal rna small subunit methyltransferase
KM392_RS19695	COG3679	Belongs to the UPF0342 family
KM392_RS19700	COG0406	alpha-ribazole phosphatase activity
KM392_RS19715	COG2340	Cysteine-rich secretory protein family
KM392_RS19730	COG3336	cytochrome c oxidase
KM392_RS19765	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KM392_RS19770	COG0772	Belongs to the SEDS family
KM392_RS19780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KM392_RS19785	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KM392_RS19795	COG4896	Protein conserved in bacteria
KM392_RS19810	COG1217	gtp-binding protein TYPA
KM392_RS19820	COG0483	inositol monophosphate 1-phosphatase activity
KM392_RS19840	COG1982	Orn Lys Arg decarboxylase major
KM392_RS19890	COG0022	dehydrogenase e1 component
KM392_RS19895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM392_RS19905	COG0242	peptide deformylase activity
KM392_RS19920	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM392_RS19925	COG0569	domain protein
KM392_RS19945	COG0583	DNA-binding transcription factor activity
KM392_RS19950	COG0517	IMP dehydrogenase activity
KM392_RS19960	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
KM392_RS19970	COG4703	Protein of unknown function (DUF1797)
KM392_RS19985	COG2200	EAL domain
KM392_RS19990	COG1028	Short-chain dehydrogenase reductase Sdr
KM392_RS19995	COG1408	metallophosphoesterase
KM392_RS20040	COG2814	Major facilitator Superfamily
KM392_RS20060	COG3209	COG3209 Rhs family protein
KM392_RS20070	COG2205	protein histidine kinase activity
KM392_RS20080	COG0436	Aminotransferase
KM392_RS20085	COG1609	Transcriptional regulator
KM392_RS20090	COG3833	ABC-type maltose transport systems, permease component
KM392_RS20095	COG1175	transmembrane transport
KM392_RS20100	COG2182	Extracellular solute-binding protein
KM392_RS20110	COG0366	Alpha amylase catalytic
KM392_RS20115	COG3842	ATPase activity
KM392_RS20155	COG0183	Belongs to the thiolase family
KM392_RS20190	COG1695	Transcriptional regulator
KM392_RS20195	COG1028	Short-chain dehydrogenase reductase Sdr
KM392_RS20205	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KM392_RS20215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KM392_RS20220	COG0436	Aminotransferase
KM392_RS20240	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KM392_RS20260	COG2199	diguanylate cyclase activity
KM392_RS20265	COG0778	Nitroreductase
KM392_RS20290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM392_RS20290	COG2190	(PTS) system
KM392_RS20290	COG1263	PTS System
KM392_RS20295	COG3711	transcriptional antiterminator
KM392_RS20305	COG2188	Transcriptional regulator
KM392_RS20315	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KM392_RS20345	COG0456	acetyltransferase
KM392_RS20355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KM392_RS20360	COG4086	secreted protein
KM392_RS20365	COG0561	phosphatase activity
KM392_RS20370	COG0697	spore germination
KM392_RS20385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM392_RS20410	COG0733	neurotransmitter:sodium symporter activity
KM392_RS20430	COG1686	Belongs to the peptidase S11 family
KM392_RS20435	COG1725	Transcriptional regulator
KM392_RS20440	COG1131	(ABC) transporter
KM392_RS20455	COG1846	Transcriptional regulator
KM392_RS20470	COG0598	Magnesium transport protein CorA
KM392_RS20495	COG4974	Belongs to the 'phage' integrase family
KM392_RS20505	COG0735	belongs to the Fur family
KM392_RS20510	COG1300	Membrane
KM392_RS20530	COG0667	Aldo Keto reductase
KM392_RS20535	COG0656	L-ascorbic acid biosynthetic process
KM392_RS20540	COG0456	acetyltransferase
KM392_RS20540	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM392_RS20550	COG1525	nuclease
KM392_RS20550	COG0737	Belongs to the 5'-nucleotidase family
KM392_RS20550	COG4085	toxin activity
KM392_RS20560	COG0596	Alpha beta hydrolase
KM392_RS20565	COG2056	Na+-H+ antiporter family
KM392_RS20570	COG1609	Transcriptional regulator
KM392_RS20575	COG0456	acetyltransferase
KM392_RS20580	COG1073	alpha beta
KM392_RS20595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM392_RS20595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM392_RS20600	COG0307	riboflavin synthase, alpha
KM392_RS20625	COG4106	trans-aconitate 2-methyltransferase activity
KM392_RS20630	COG1073	alpha beta
KM392_RS20630	COG2226	methyltransferase
KM392_RS20645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM392_RS20655	COG1757	Na H antiporter
KM392_RS20660	COG0737	Belongs to the 5'-nucleotidase family
KM392_RS20670	COG1522	sequence-specific DNA binding
KM392_RS20690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM392_RS20700	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KM392_RS20715	COG0300	oxidoreductase activity
KM392_RS20720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM392_RS20725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM392_RS20730	COG1760	l-serine dehydratase
KM392_RS20735	COG1760	l-serine dehydratase
KM392_RS20755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM392_RS20765	COG2195	Cleaves the N-terminal amino acid of tripeptides
KM392_RS20770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM392_RS20785	COG1376	ErfK ybiS ycfS ynhG family protein
KM392_RS20790	COG4129	membrane
KM392_RS20795	COG1126	abc transporter atp-binding protein
KM392_RS20800	COG0765	amino acid transport
KM392_RS20805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM392_RS20820	COG2816	NAD+ diphosphatase activity
KM392_RS20825	COG0772	Belongs to the SEDS family
KM392_RS20830	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM392_RS20835	COG0022	dehydrogenase e1 component
KM392_RS20840	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM392_RS20845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM392_RS20860	COG0280	phosphate acetyltransferase
KM392_RS20865	COG3290	protein histidine kinase activity
KM392_RS20865	COG3829	transcription factor binding
KM392_RS20875	COG0584	glycerophosphoryl diester phosphodiesterase
KM392_RS20880	COG3093	addiction module antidote protein HigA
KM392_RS20890	COG0745	RESPONSE REGULATOR receiver
KM392_RS20895	COG0750	zinc metalloprotease
KM392_RS20900	COG0497	DNA recombination
KM392_RS20910	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KM392_RS20920	COG0142	geranyltranstransferase activity
KM392_RS20945	COG1302	Protein conserved in bacteria
KM392_RS20950	COG0439	Biotin carboxylase
KM392_RS20955	COG0511	ligase activity, forming carbon-carbon bonds
KM392_RS21000	COG3854	ATPases associated with a variety of cellular activities
KM392_RS21025	COG0006	proline dipeptidase activity
KM392_RS21040	COG3872	metal-dependent enzyme
KM392_RS21050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KM392_RS21070	COG0095	Lipoate-protein ligase
KM392_RS21075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM392_RS21080	COG1609	Transcriptional regulator
KM392_RS21090	COG2076	Multidrug Resistance protein
KM392_RS21095	COG2076	Multidrug Resistance protein
KM392_RS21130	COG1131	(ABC) transporter
KM392_RS21135	COG1725	Transcriptional regulator
KM392_RS21165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM392_RS21220	COG4970	Tfp pilus assembly protein FimT
KM392_RS21225	COG4537	Required for transformation and DNA binding
KM392_RS21230	COG1459	type II secretion system
KM392_RS21235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KM392_RS21285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KM392_RS21295	COG0646	methionine synthase
KM392_RS21295	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KM392_RS21300	COG0626	cystathionine gamma-synthase activity
KM392_RS21305	COG0626	cystathionine gamma-synthase activity
KM392_RS21325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM392_RS21335	COG1940	carbohydrate kinase activity
KM392_RS21340	COG4483	Protein conserved in bacteria
KM392_RS21345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KM392_RS21350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KM392_RS21355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KM392_RS21360	COG0704	Plays a role in the regulation of phosphate uptake
KM392_RS21370	COG0581	inorganic phosphate transmembrane transporter activity
KM392_RS21375	COG0573	inorganic phosphate transmembrane transporter activity
KM392_RS21380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM392_RS21385	COG0768	penicillin binding
KM392_RS21390	COG0477	Major facilitator Superfamily
KM392_RS21395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM392_RS21420	COG0735	belongs to the Fur family
KM392_RS21425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KM392_RS21430	COG1121	(ABC) transporter
KM392_RS21435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM392_RS21465	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KM392_RS21470	COG2384	SAM-dependent methyltransferase
KM392_RS21475	COG2010	Cytochrome c
KM392_RS21480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KM392_RS21485	COG0358	DNA primase activity
KM392_RS21495	COG0517	IMP dehydrogenase activity
KM392_RS21510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KM392_RS21515	COG0295	cytidine deaminase activity
KM392_RS21520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KM392_RS21530	COG1480	7TM receptor with intracellular HD hydrolase
KM392_RS21535	COG1702	phosphate starvation-inducible protein PhoH
KM392_RS21550	COG1610	YqeY-like protein
KM392_RS21555	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KM392_RS21560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KM392_RS21565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KM392_RS21595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM392_RS21600	COG1733	regulation of RNA biosynthetic process
KM392_RS21625	COG1466	dna polymerase III delta subunit
KM392_RS21640	COG2131	deaminase
KM392_RS21645	COG1555	photosystem II stabilization
KM392_RS21645	COG1596	polysaccharide export
KM392_RS21650	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM392_RS21655	COG2226	methyltransferase
KM392_RS21660	COG0799	negative regulation of ribosome biogenesis
KM392_RS21665	COG1713	HD superfamily hydrolase involved in NAD metabolism
KM392_RS21675	COG1534	Rna-binding protein
KM392_RS21685	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KM392_RS21690	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KM392_RS21715	COG1595	DNA-templated transcription, initiation
KM392_RS21725	COG0778	Nitroreductase
KM392_RS21730	COG2357	RelA SpoT domain protein
KM392_RS21740	COG1785	Belongs to the alkaline phosphatase family
KM392_RS21750	COG2267	carboxylic ester hydrolase activity
KM392_RS21785	COG1404	Belongs to the peptidase S8 family
KM392_RS21790	COG3186	Phenylalanine-4-hydroxylase
KM392_RS21800	COG2514	catechol 2,3-dioxygenase activity
KM392_RS21805	COG2259	Doxx family
KM392_RS21845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM392_RS21855	COG1454	alcohol dehydrogenase
KM392_RS21855	COG1012	belongs to the aldehyde dehydrogenase family
KM392_RS21860	COG0626	cystathionine gamma-synthase activity
KM392_RS21865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM392_RS21890	COG0768	penicillin binding
KM392_RS21905	COG0826	peptidase U32
KM392_RS21910	COG0826	peptidase U32
KM392_RS21915	COG4122	O-methyltransferase activity
KM392_RS21920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KM392_RS21940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM392_RS21950	COG0628	permease
KM392_RS21970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KM392_RS21980	COG0482	sulfurtransferase activity
KM392_RS21985	COG1104	cysteine desulfurase activity
KM392_RS21990	COG1959	2 iron, 2 sulfur cluster binding
KM392_RS21995	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KM392_RS22005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KM392_RS22030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KM392_RS22040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KM392_RS22040	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KM392_RS22045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KM392_RS22050	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM392_RS22050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM392_RS22060	COG2244	polysaccharide biosynthetic process
KM392_RS22065	COG2323	membrane
KM392_RS22075	COG1862	Preprotein translocase
KM392_RS22105	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KM392_RS22115	COG0697	spore germination
KM392_RS22120	COG0697	spore germination
KM392_RS22125	COG0640	Transcriptional regulator
KM392_RS22150	COG0157	Belongs to the NadC ModD family
KM392_RS22155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KM392_RS22160	COG1104	cysteine desulfurase activity
KM392_RS22165	COG1827	regulation of RNA biosynthetic process
KM392_RS22170	COG2258	MOSC domain
KM392_RS22175	COG0077	Prephenate dehydratase
KM392_RS22180	COG0577	efflux transmembrane transporter activity
KM392_RS22185	COG0577	efflux transmembrane transporter activity
KM392_RS22190	COG1136	(ABC) transporter
KM392_RS22200	COG0745	RESPONSE REGULATOR receiver
KM392_RS22205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KM392_RS22210	COG3290	protein histidine kinase activity
KM392_RS22220	COG2868	ribosomal protein
KM392_RS22230	COG1530	ribonuclease E activity
KM392_RS22235	COG1994	Peptidase M50
KM392_RS22240	COG0739	heme binding
KM392_RS22245	COG2894	cell division
KM392_RS22265	COG1077	Cell shape determining protein MreB Mrl
KM392_RS22285	COG0285	dihydrofolate synthase activity
KM392_RS22290	COG0525	valine-tRNA ligase activity
KM392_RS22300	COG1388	LysM domain
KM392_RS22310	COG0113	porphobilinogen synthase activity
KM392_RS22315	COG1587	Uroporphyrinogen-III synthase
KM392_RS22325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KM392_RS22335	COG1846	Transcriptional regulator
KM392_RS22340	COG1764	response to oxidative stress
KM392_RS22355	COG0470	DNA polymerase III
KM392_RS22355	COG1067	ATP-dependent peptidase activity
KM392_RS22400	COG0622	Phosphoesterase
KM392_RS22415	COG5401	PFAM Sporulation and spore germination
KM392_RS22435	COG1309	transcriptional regulator
KM392_RS22450	COG2197	response regulator
KM392_RS22455	COG2233	PERMEase
KM392_RS22465	COG0402	S-adenosylhomocysteine deaminase activity
KM392_RS22470	COG0402	S-adenosylhomocysteine deaminase activity
KM392_RS22480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM392_RS22490	COG0444	Belongs to the ABC transporter superfamily
KM392_RS22495	COG4608	Belongs to the ABC transporter superfamily
KM392_RS22500	COG3275	phosphorelay sensor kinase activity
KM392_RS22505	COG3279	Response regulator of the LytR AlgR family
KM392_RS22520	COG1983	PspC domain protein
KM392_RS22525	COG1396	sequence-specific DNA binding
KM392_RS22530	COG0697	spore germination
KM392_RS22540	COG1959	2 iron, 2 sulfur cluster binding
KM392_RS22545	COG1668	transmembrane transport
KM392_RS22555	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KM392_RS22565	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM392_RS22570	COG1876	peptidase activity
KM392_RS22575	COG0824	Thioesterase
KM392_RS22580	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KM392_RS22585	COG1053	succinate dehydrogenase
KM392_RS22590	COG2009	succinate dehydrogenase
KM392_RS22595	COG1719	4-vinyl reductase, 4VR
KM392_RS22605	COG3118	belongs to the thioredoxin family
KM392_RS22610	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KM392_RS22615	COG2086	electron transfer activity
KM392_RS22620	COG1024	Enoyl-CoA hydratase
KM392_RS22625	COG1309	transcriptional regulator
KM392_RS22630	COG0318	PFAM AMP-dependent synthetase and ligase
KM392_RS22650	COG2318	DinB family
KM392_RS22680	COG1131	(ABC) transporter
KM392_RS22685	COG2205	protein histidine kinase activity
KM392_RS22690	COG0745	RESPONSE REGULATOR receiver
KM392_RS22700	COG4895	conserved protein (DUF2196)
KM392_RS22705	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KM392_RS22720	COG4509	Sortase family
KM392_RS22725	COG1120	ATPase activity
KM392_RS22740	COG5386	Cell surface protein
KM392_RS22750	COG5386	Cell surface protein
KM392_RS22755	COG1114	Component of the transport system for branched-chain amino acids
KM392_RS22760	COG1187	pseudouridine synthase activity
KM392_RS22770	COG1796	DNA polymerase
KM392_RS22770	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KM392_RS22775	COG1286	toxin biosynthetic process
KM392_RS22820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM392_RS22830	COG1418	mRNA catabolic process
KM392_RS22855	COG2814	Major facilitator Superfamily
KM392_RS22860	COG1566	PFAM secretion protein HlyD family protein
KM392_RS22865	COG1309	transcriptional regulator
KM392_RS22870	COG1363	Peptidase, m42
KM392_RS22895	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM392_RS22905	COG1484	DNA-dependent DNA replication
KM392_RS22910	COG3611	Membrane attachment protein
KM392_RS22920	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM392_RS22925	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM392_RS22930	COG0237	dephospho-CoA kinase activity
KM392_RS22935	COG1971	Probably functions as a manganese efflux pump
KM392_RS22945	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM392_RS22945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM392_RS22950	COG5002	protein histidine kinase activity
KM392_RS22955	COG0745	RESPONSE REGULATOR receiver
KM392_RS22975	COG0538	isocitrate dehydrogenase activity
KM392_RS22980	COG0372	Belongs to the citrate synthase family
KM392_RS22990	COG0628	permease
KM392_RS22995	COG3030	protein affecting phage T7 exclusion by the F plasmid
KM392_RS23020	COG1725	Transcriptional regulator
KM392_RS23025	COG0281	malic enzyme
KM392_RS23030	COG0587	DNA-directed DNA polymerase activity
KM392_RS23045	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KM392_RS23065	COG4109	DRTGG domain
KM392_RS23080	COG0006	proline dipeptidase activity
KM392_RS23120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM392_RS23125	COG0662	Cupin 2, conserved barrel domain protein
KM392_RS23135	COG1476	TRANSCRIPTIONal
KM392_RS23150	COG1028	Short-chain dehydrogenase reductase Sdr
KM392_RS23155	COG0589	response to stress
KM392_RS23195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM392_RS23215	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KM392_RS23220	COG0827	DNA restriction-modification system
KM392_RS23225	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KM392_RS23230	COG3874	Sporulation protein YtfJ
KM392_RS23245	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KM392_RS23255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM392_RS23270	COG1104	cysteine desulfurase activity
KM392_RS23280	COG0583	DNA-binding transcription factor activity
KM392_RS23285	COG0697	spore germination
KM392_RS23295	COG1956	GAF domain-containing protein
KM392_RS23300	COG0626	cystathionine gamma-synthase activity
KM392_RS23330	COG1595	DNA-templated transcription, initiation
KM392_RS23340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM392_RS23345	COG0454	-acetyltransferase
KM392_RS23350	COG0517	IMP dehydrogenase activity
KM392_RS23355	COG0123	including yeast histone deacetylase and acetoin utilization protein
KM392_RS23365	COG0745	RESPONSE REGULATOR receiver
KM392_RS23375	COG0666	response to abiotic stimulus
KM392_RS23410	COG1609	Transcriptional regulator
KM392_RS23415	COG4851	CamS sex pheromone cAM373 precursor
KM392_RS23420	COG3118	belongs to the thioredoxin family
KM392_RS23430	COG2309	aminopeptidase activity
KM392_RS23450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM392_RS23465	COG1674	ftsk spoiiie
KM392_RS23475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM392_RS23480	COG4848	Belongs to the UPF0354 family
KM392_RS23485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM392_RS23490	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
KM392_RS23495	COG1363	Peptidase, m42
KM392_RS23505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM392_RS23520	COG0510	thiamine kinase activity
KM392_RS23525	COG1523	belongs to the glycosyl hydrolase 13 family
KM392_RS23535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM392_RS23540	COG1349	DNA-binding transcription factor activity
KM392_RS23545	COG1187	pseudouridine synthase activity
KM392_RS23550	COG2244	polysaccharide biosynthetic process
KM392_RS23555	COG2081	HI0933 family
KM392_RS23560	COG2814	Major facilitator Superfamily
KM392_RS23570	COG3832	glyoxalase III activity
KM392_RS23600	COG4975	Glucose uptake
KM392_RS23615	COG0314	molybdopterin synthase activity
KM392_RS23620	COG1763	Mo-molybdopterin cofactor biosynthetic process
KM392_RS23625	COG0303	'Molybdopterin
KM392_RS23635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM392_RS23640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KM392_RS23665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM392_RS23675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM392_RS23720	COG2814	Major facilitator Superfamily
KM392_RS23725	COG0475	glutathione-regulated potassium exporter activity
KM392_RS23730	COG0490	domain, Protein
KM392_RS23735	COG0582	viral genome integration into host DNA
KM392_RS23745	COG1136	(ABC) transporter
KM392_RS23765	COG1242	4 iron, 4 sulfur cluster binding
KM392_RS23770	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KM392_RS23775	COG1131	(ABC) transporter
KM392_RS23785	COG1794	racemase activity, acting on amino acids and derivatives
KM392_RS23805	COG2267	carboxylic ester hydrolase activity
KM392_RS23810	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KM392_RS23815	COG0671	phosphoesterase, PA-phosphatase related
KM392_RS23820	COG0438	transferase activity, transferring glycosyl groups
KM392_RS23830	COG0521	Mo-molybdopterin cofactor biosynthetic process
KM392_RS23885	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KM392_RS23890	COG5002	protein histidine kinase activity
KM392_RS23895	COG4191	Histidine kinase
KM392_RS23900	COG2267	carboxylic ester hydrolase activity
KM392_RS23920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM392_RS23925	COG1116	anion transmembrane transporter activity
KM392_RS23930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM392_RS23955	COG0494	nUDIX hydrolase
KM392_RS23990	COG0288	reversible hydration of carbon dioxide
KM392_RS23995	COG1271	oxidase subunit
KM392_RS24000	COG1294	oxidase, subunit
KM392_RS24020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM392_RS24045	COG1842	Phage shock protein A
KM392_RS24075	COG5002	protein histidine kinase activity
KM392_RS24080	COG0745	RESPONSE REGULATOR receiver
KM392_RS24105	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KM392_RS24110	COG1597	lipid kinase activity
KM392_RS24145	COG0586	Pfam SNARE associated Golgi protein
KM392_RS24155	COG0577	efflux transmembrane transporter activity
KM392_RS24160	COG1136	(ABC) transporter
KM392_RS24170	COG0745	RESPONSE REGULATOR receiver
KM392_RS24175	COG2205	protein histidine kinase activity
KM392_RS24180	COG0577	efflux transmembrane transporter activity
KM392_RS24185	COG0577	efflux transmembrane transporter activity
KM392_RS24190	COG1136	(ABC) transporter
KM392_RS24210	COG2188	Transcriptional regulator
KM392_RS24230	COG3964	amidohydrolase
KM392_RS24260	COG4948	Mandelate Racemase Muconate Lactonizing
KM392_RS24270	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KM392_RS24275	COG0596	Alpha beta hydrolase
KM392_RS24280	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KM392_RS24285	COG1169	isochorismate synthase
KM392_RS24290	COG1575	Belongs to the MenA family. Type 1 subfamily
KM392_RS24295	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KM392_RS24315	COG0058	SHG alpha-glucan phosphorylase activity
KM392_RS24320	COG0297	glycogen (starch) synthase activity
KM392_RS24325	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KM392_RS24440	COG0544	peptidyl-prolyl cis-trans isomerase activity
KM392_RS24475	COG1285	pathogenesis
KM392_RS24480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM392_RS24490	COG0166	Belongs to the GPI family
KM392_RS24495	COG2155	Conserved Protein
KM392_RS24500	COG1098	S1 RNA binding domain
KM392_RS24505	COG0436	Aminotransferase
KM392_RS24510	COG1522	sequence-specific DNA binding
KM392_RS24515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KM392_RS24520	COG2267	carboxylic ester hydrolase activity
KM392_RS24530	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KM392_RS24550	COG5018	Exonuclease
KM392_RS24555	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM392_RS24575	COG2050	protein possibly involved in aromatic compounds catabolism
KM392_RS24585	COG1268	BioY protein
KM392_RS24595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM392_RS24600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KM392_RS24615	COG3584	3D domain protein
KM392_RS24630	COG1252	NADH dehydrogenase
KM392_RS24645	COG3708	Transcriptional regulator
KM392_RS24660	COG1683	Conserved Protein
KM392_RS24680	COG0316	Belongs to the HesB IscA family
KM392_RS24695	COG1252	NADH dehydrogenase
KM392_RS24705	COG2274	protein secretion by the type I secretion system
KM392_RS24710	COG0390	transport system, permease component
KM392_RS24715	COG2824	Alkylphosphonate utilization operon protein PhnA
KM392_RS24755	COG4837	Protein of unknown function (DUF1462)
KM392_RS24760	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KM392_RS24770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM392_RS24775	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KM392_RS24785	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM392_RS24790	COG0647	UMP catabolic process
KM392_RS24800	COG2445	Protein of unknown function DUF86
KM392_RS24805	COG1494	fructose-1,6-bisphosphatase
KM392_RS24820	COG4470	Protein conserved in bacteria
KM392_RS24830	COG0789	Transcriptional regulator
KM392_RS24835	COG4377	Putative membrane peptidase family (DUF2324)
KM392_RS24860	COG0739	heme binding
KM392_RS24870	COG3377	Domain of unknown function (DUF1805)
KM392_RS24875	COG0737	Belongs to the 5'-nucleotidase family
KM392_RS24880	COG1695	Transcriptional regulator
KM392_RS24890	COG0719	Fe-S assembly protein
KM392_RS24895	COG0822	iron-sulfur transferase activity
KM392_RS24900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KM392_RS24905	COG0719	Fe-S assembly protein
KM392_RS24910	COG0396	ATPase activity
KM392_RS24915	COG1464	Belongs to the NlpA lipoprotein family
KM392_RS24920	COG1464	Belongs to the NlpA lipoprotein family
KM392_RS24925	COG2011	ABC-type metal ion transport system permease component
KM392_RS24930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM392_RS24940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM392_RS24945	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KM392_RS24955	COG1393	Belongs to the ArsC family
KM392_RS25000	COG0039	L-malate dehydrogenase activity
KM392_RS25025	COG1309	transcriptional regulator
KM392_RS25030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM392_RS25035	COG1960	acyl-CoA dehydrogenase activity
KM392_RS25040	COG0183	Belongs to the thiolase family
KM392_RS25045	COG1024	Enoyl-CoA hydratase
KM392_RS25045	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM392_RS25055	COG1686	Belongs to the peptidase S11 family
KM392_RS25070	COG0011	TIGRFAM Protein of
KM392_RS25075	COG0840	transmembrane signaling receptor activity
KM392_RS25095	COG2814	Major facilitator Superfamily
KM392_RS25100	COG0531	amino acid
KM392_RS25110	COG0706	membrane insertase activity
KM392_RS25120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM392_RS25155	COG0586	Pfam SNARE associated Golgi protein
KM392_RS25165	COG1376	ErfK ybiS ycfS ynhG family protein
KM392_RS25170	COG0745	RESPONSE REGULATOR receiver
KM392_RS25175	COG5002	protein histidine kinase activity
KM392_RS25200	COG2151	metal-sulfur cluster biosynthetic enzyme
KM392_RS25205	COG3227	Zinc metalloprotease (Elastase)
KM392_RS25210	COG1741	Belongs to the pirin family
KM392_RS25225	COG0475	glutathione-regulated potassium exporter activity
KM392_RS25230	COG0490	domain, Protein
KM392_RS25235	COG1115	amino acid carrier protein
KM392_RS25240	COG0783	Belongs to the Dps family
KM392_RS25255	COG1611	Belongs to the LOG family
KM392_RS25275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM392_RS25280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM392_RS25285	COG1115	amino acid carrier protein
KM392_RS25290	COG1115	amino acid carrier protein
KM392_RS25295	COG2910	NAD(P)H-binding
KM392_RS25310	COG0656	L-ascorbic acid biosynthetic process
KM392_RS25315	COG2814	Major facilitator Superfamily
KM392_RS25320	COG1733	regulation of RNA biosynthetic process
KM392_RS25330	COG1252	NADH dehydrogenase
KM392_RS25335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KM392_RS25340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM392_RS25350	COG0840	transmembrane signaling receptor activity
KM392_RS25350	COG3290	protein histidine kinase activity
KM392_RS25360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KM392_RS25365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KM392_RS25380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM392_RS25435	COG0557	exoribonuclease II activity
KM392_RS25440	COG1647	Serine aminopeptidase, S33
KM392_RS25445	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM392_RS25450	COG1346	cytolysis
KM392_RS25545	COG4695	Portal protein
KM392_RS25565	COG4974	Belongs to the 'phage' integrase family
KM392_RS25580	COG0149	triose-phosphate isomerase activity
KM392_RS25590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM392_RS25605	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KM392_RS25630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM392_RS25645	COG2323	membrane
KM392_RS25650	COG0740	serine-type endopeptidase activity
KM392_RS25655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM392_RS25665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KM392_RS25675	COG1051	belongs to the nudix hydrolase family
KM392_RS25685	COG0492	ferredoxin-NADP+ reductase activity
KM392_RS25690	COG0457	Tetratricopeptide repeat
KM392_RS25695	COG0110	maltose O-acetyltransferase activity
KM392_RS25715	COG1950	PFAM Membrane protein of
KM392_RS25725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM392_RS25730	COG0556	nucleotide-excision repair
KM392_RS25750	COG0789	Transcriptional regulator
KM392_RS25775	COG2855	membrane
KM392_RS25780	COG0583	DNA-binding transcription factor activity
KM392_RS25790	COG0655	NAD(P)H dehydrogenase (quinone) activity
KM392_RS25795	COG0488	(ABC) transporter
KM392_RS25805	COG1132	(ABC) transporter
KM392_RS25810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM392_RS25815	COG0793	Belongs to the peptidase S41A family
KM392_RS25815	COG3409	Peptidoglycan-binding domain 1 protein
KM392_RS25820	COG2177	Part of the ABC transporter FtsEX involved in
KM392_RS25825	COG2884	Cell division ATP-binding protein ftsE
KM392_RS25840	COG0653	protein targeting
KM392_RS25845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KM392_RS25850	COG1278	Cold shock
KM392_RS25855	COG1040	competence protein
KM392_RS25865	COG0791	NLP P60 protein
KM392_RS25865	COG1388	LysM domain
KM392_RS25870	COG1733	regulation of RNA biosynthetic process
KM392_RS25875	COG1307	EDD domain protein, DegV family
KM392_RS25880	COG1739	Uncharacterized protein family UPF0029
KM392_RS25885	COG1316	TRANSCRIPTIONal
KM392_RS25890	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM392_RS25895	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KM392_RS25900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KM392_RS25910	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KM392_RS25910	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KM392_RS25925	COG3394	polysaccharide catabolic process
KM392_RS25930	COG1486	melibiose metabolic process
KM392_RS25935	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM392_RS25940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM392_RS25950	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KM392_RS25955	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM392_RS25960	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM392_RS25970	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM392_RS25975	COG1301	dicarboxylic acid transport
KM392_RS25985	COG0346	lactoylglutathione lyase activity
KM392_RS25990	COG1511	domain protein
KM392_RS25995	COG0583	DNA-binding transcription factor activity
KM392_RS26000	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KM392_RS26015	COG1271	oxidase subunit
KM392_RS26020	COG1294	oxidase, subunit
KM392_RS26025	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM392_RS26045	COG2389	metal-binding protein
KM392_RS26055	COG1368	sulfuric ester hydrolase activity
KM392_RS26070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM392_RS26080	COG1215	transferase activity, transferring glycosyl groups
KM392_RS26085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM392_RS26090	COG3584	3D domain protein
KM392_RS26090	COG1388	LysM domain
KM392_RS26115	COG4715	Zinc finger, swim domain protein
KM392_RS26120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM392_RS26160	COG0577	efflux transmembrane transporter activity
KM392_RS26165	COG1136	(ABC) transporter
KM392_RS26200	COG5002	protein histidine kinase activity
KM392_RS26205	COG0745	RESPONSE REGULATOR receiver
KM392_RS26210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KM392_RS26230	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM392_RS26235	COG1134	teichoic acid transport
KM392_RS26240	COG1682	transport, permease protein
KM392_RS26245	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KM392_RS26290	COG1609	Transcriptional regulator
KM392_RS26305	COG0739	heme binding
KM392_RS26325	COG2385	sporulation resulting in formation of a cellular spore
KM392_RS26340	COG4836	Membrane
KM392_RS26345	COG1007	ATP synthesis coupled electron transport
KM392_RS26350	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM392_RS26355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM392_RS26365	COG0839	Belongs to the complex I subunit 6 family
KM392_RS26380	COG0649	NAD binding
KM392_RS26385	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM392_RS26400	COG3300	MHYT domain
KM392_RS26400	COG5001	Diguanylate cyclase
KM392_RS26450	COG0356	it plays a direct role in the translocation of protons across the membrane
KM392_RS26485	COG0698	ribose 5-phosphate isomerase
KM392_RS26495	COG2190	(PTS) system
KM392_RS26500	COG2259	Doxx family
KM392_RS26505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KM392_RS26520	COG0009	L-threonylcarbamoyladenylate synthase
KM392_RS26535	COG2890	protein-(glutamine-N5) methyltransferase activity
KM392_RS26555	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KM392_RS26560	COG1494	fructose-1,6-bisphosphatase
KM392_RS26580	COG4821	SIS domain
KM392_RS26590	COG3343	RNA polymerase activity
KM392_RS26600	COG1960	acyl-CoA dehydrogenase activity
KM392_RS26605	COG1960	acyl-CoA dehydrogenase activity
KM392_RS26610	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM392_RS26615	COG0183	Belongs to the thiolase family
KM392_RS26620	COG0247	lactate metabolic process
KM392_RS26620	COG2181	nitrate reductase activity
KM392_RS26625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM392_RS26635	COG3300	MHYT domain
KM392_RS26635	COG5001	Diguanylate cyclase
KM392_RS26655	COG2197	response regulator
KM392_RS26660	COG4585	Histidine kinase
KM392_RS26665	COG0842	Transport permease protein
KM392_RS26670	COG1131	(ABC) transporter
KM392_RS26675	COG0024	Methionine aminopeptidase
KM392_RS26685	COG2234	aminopeptidase activity
KM392_RS26705	COG1595	DNA-templated transcription, initiation
KM392_RS26710	COG0018	arginyl-trna synthetase
KM392_RS26715	COG4506	Protein conserved in bacteria
KM392_RS26720	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM392_RS26735	COG0010	Belongs to the arginase family
KM392_RS26745	COG2814	Major facilitator Superfamily
KM392_RS26750	COG0789	Transcriptional regulator
KM392_RS26755	COG0584	glycerophosphoryl diester phosphodiesterase
KM392_RS26760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM392_RS26770	COG1994	Peptidase M50
KM392_RS26780	COG1078	dGTPase activity
KM392_RS26785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM392_RS26790	COG1120	ATPase activity
KM392_RS26795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM392_RS26800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM392_RS26820	COG0095	Lipoate-protein ligase
KM392_RS26825	COG0280	phosphate acetyltransferase
KM392_RS26840	COG3773	Cell wall hydrolase
KM392_RS26850	COG2363	Small membrane protein
KM392_RS26860	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM392_RS26865	COG2233	PERMEase
KM392_RS26870	COG0561	phosphatase activity
KM392_RS26875	COG2814	Major facilitator Superfamily
KM392_RS26885	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM392_RS26890	COG1131	(ABC) transporter
KM392_RS26895	COG2755	lipolytic protein G-D-S-L family
KM392_RS26900	COG1609	Transcriptional regulator
KM392_RS26910	COG0460	homoserine dehydrogenase
KM392_RS26920	COG2873	o-acetylhomoserine
KM392_RS26930	COG1011	Hydrolase
KM392_RS26935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM392_RS26945	COG2197	response regulator
KM392_RS26955	COG0351	phosphomethylpyrimidine kinase
KM392_RS26960	COG3706	GGDEF domain
KM392_RS26965	COG2879	small protein
KM392_RS26970	COG1966	Carbon starvation protein
KM392_RS26975	COG3279	Response regulator of the LytR AlgR family
KM392_RS26980	COG0477	Major facilitator Superfamily
KM392_RS27015	COG1607	acyl-coa hydrolase
KM392_RS27030	COG0488	(ABC) transporter
KM392_RS27050	COG0463	Glycosyl transferase, family 2
KM392_RS27055	COG1309	transcriptional regulator
KM392_RS27060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM392_RS27065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM392_RS27065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM392_RS27070	COG0628	permease
KM392_RS27085	COG3279	Response regulator of the LytR AlgR family
KM392_RS27090	COG3275	phosphorelay sensor kinase activity
KM392_RS27095	COG2814	Major facilitator Superfamily
KM392_RS27100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM392_RS27105	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
KM392_RS27110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM392_RS27130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KM392_RS27135	COG1272	protein, Hemolysin III
KM392_RS27160	COG1164	Oligoendopeptidase f
KM392_RS27180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM392_RS27185	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KM392_RS27190	COG4853	Protein conserved in bacteria
KM392_RS27195	COG4863	YycH protein
KM392_RS27200	COG5002	protein histidine kinase activity
KM392_RS27205	COG0745	RESPONSE REGULATOR receiver
KM392_RS27235	COG0305	Participates in initiation and elongation during chromosome replication
KM392_RS27245	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KM392_RS27250	COG4241	membrane
KM392_RS27260	COG0629	single-stranded DNA binding
KM392_RS27270	COG0012	GTP binding
KM392_RS27275	COG4481	Protein conserved in bacteria
KM392_RS27280	COG0668	transmembrane transport
KM392_RS27290	COG1475	DNA binding
KM392_RS27295	COG1192	Involved in chromosome partitioning
KM392_RS27320	COG1847	R3H domain protein
KM392_RS27325	COG0706	membrane insertase activity
KM392_RS27335	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KM392_RS27390	COG3344	reverse transcriptase
KM392_RS27475	COG3344	reverse transcriptase
KM392_RS27670	COG4962	Type ii secretion system protein e
KM392_RS27810	COG2311	Membrane
KM392_RS27835	COG4196	transglutaminase domain protein
KM392_RS27840	COG0671	phosphoesterase, PA-phosphatase related
KM392_RS27860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM392_RS27865	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KM392_RS28040	COG2002	toxin-antitoxin pair type II binding
KM392_RS28050	COG4974	Belongs to the 'phage' integrase family
KM392_RS28110	COG3443	Belongs to the bacterial solute-binding protein 9 family
KM392_RS28120	COG4974	Belongs to the 'phage' integrase family
KM392_RS28145	COG0457	Tetratricopeptide repeat
KM392_RS28470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM392_RS28480	COG4166	transmembrane transport
KM392_RS28525	COG1280	lysine exporter protein (LysE YggA)
KM392_RS28555	COG0681	Belongs to the peptidase S26 family
KM392_RS28630	COG1309	transcriptional regulator
KM392_RS28635	COG1683	Conserved Protein
KM392_RS28680	COG1192	Involved in chromosome partitioning