locus-tag	class	description
TD69_RS00010	COG0592	DNA-directed DNA polymerase activity
TD69_RS00015	COG2501	S4 domain
TD69_RS00025	COG0187	DNA topoisomerase II activity
TD69_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TD69_RS00065	COG0516	GMP reductase activity
TD69_RS00065	COG0517	IMP dehydrogenase activity
TD69_RS00070	COG1686	Belongs to the peptidase S11 family
TD69_RS00100	COG1428	Deoxynucleoside kinase
TD69_RS00105	COG1428	Deoxynucleoside kinase
TD69_RS00110	COG1335	isochorismatase
TD69_RS00120	COG0590	tRNA wobble adenosine to inosine editing
TD69_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TD69_RS00180	COG1982	Orn Lys Arg decarboxylase major
TD69_RS00190	COG0470	DNA polymerase III
TD69_RS00195	COG1774	PSP1 C-terminal conserved region
TD69_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TD69_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TD69_RS00220	COG2002	toxin-antitoxin pair type II binding
TD69_RS00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TD69_RS00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TD69_RS00230	COG0084	hydrolase, TatD family'
TD69_RS00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
TD69_RS00250	COG4466	Protein conserved in bacteria
TD69_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TD69_RS00270	COG0251	oxidation-reduction process
TD69_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TD69_RS00305	COG2002	toxin-antitoxin pair type II binding
TD69_RS00310	COG2244	polysaccharide biosynthetic process
TD69_RS00315	COG3956	TIGRFAM MazG family protein
TD69_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TD69_RS00340	COG1098	S1 RNA binding domain
TD69_RS00355	COG2208	phosphoserine phosphatase activity
TD69_RS00360	COG0037	tRNA processing
TD69_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TD69_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TD69_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TD69_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TD69_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
TD69_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TD69_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TD69_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TD69_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TD69_RS00420	COG1396	sequence-specific DNA binding
TD69_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TD69_RS00455	COG3880	PFAM UvrB UvrC protein
TD69_RS00465	COG0542	response to heat
TD69_RS00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TD69_RS00480	COG4956	integral membrane protein (PIN domain superfamily)
TD69_RS00500	COG1045	serine acetyltransferase
TD69_RS00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TD69_RS00520	COG3688	RNA-binding protein containing a PIN domain
TD69_RS00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TD69_RS00540	COG0250	Participates in transcription elongation, termination and antitermination
TD69_RS00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TD69_RS00565	COG2813	Specifically methylates the guanine in position
TD69_RS00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TD69_RS00580	COG1358	cellular component organization or biogenesis
TD69_RS00650	COG0255	Belongs to the universal ribosomal protein uL29 family
TD69_RS00710	COG0201	protein transport
TD69_RS00720	COG0024	Methionine aminopeptidase
TD69_RS00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TD69_RS00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TD69_RS00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
TD69_RS00795	COG0489	protein tyrosine kinase activity
TD69_RS00805	COG2194	sulfuric ester hydrolase activity
TD69_RS00810	COG0726	polysaccharide deacetylase
TD69_RS00895	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TD69_RS00900	COG4856	YbbR-like protein
TD69_RS00915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TD69_RS00920	COG0596	Alpha beta hydrolase
TD69_RS00940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TD69_RS00945	COG4946	Tricorn protease homolog
TD69_RS00945	COG1506	peptidase
TD69_RS00945	COG0823	Involved in the tonB-independent uptake of proteins
TD69_RS00980	COG1028	Short-chain dehydrogenase reductase Sdr
TD69_RS00985	COG2011	ABC-type metal ion transport system permease component
TD69_RS00990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TD69_RS00995	COG1464	Belongs to the NlpA lipoprotein family
TD69_RS01000	COG0604	alcohol dehydrogenase
TD69_RS01010	COG0277	FAD linked oxidase domain protein
TD69_RS01015	COG2271	Major facilitator Superfamily
TD69_RS01025	COG2814	Major facilitator Superfamily
TD69_RS01040	COG0601	transmembrane transport
TD69_RS01045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TD69_RS01050	COG0444	Belongs to the ABC transporter superfamily
TD69_RS01055	COG4608	Belongs to the ABC transporter superfamily
TD69_RS01060	COG4166	transmembrane transport
TD69_RS01070	COG2207	Transcriptional regulator
TD69_RS01085	COG4166	transmembrane transport
TD69_RS01090	COG4166	transmembrane transport
TD69_RS01095	COG0656	L-ascorbic acid biosynthetic process
TD69_RS01100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TD69_RS01115	COG4975	Glucose uptake
TD69_RS01120	COG4149	molybdate abc transporter
TD69_RS01125	COG0725	ABC transporter, periplasmic molybdate-binding protein
TD69_RS01130	COG0725	ABC transporter, periplasmic molybdate-binding protein
TD69_RS01135	COG1910	domain protein
TD69_RS01150	COG0583	DNA-binding transcription factor activity
TD69_RS01155	COG0697	spore germination
TD69_RS01165	COG0204	Acyl-transferase
TD69_RS01175	COG1609	Transcriptional regulator
TD69_RS01185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TD69_RS01200	COG0084	hydrolase, TatD family'
TD69_RS01205	COG5298	Protein conserved in bacteria
TD69_RS01230	COG0488	(ABC) transporter
TD69_RS01245	COG0747	negative chemotaxis
TD69_RS01250	COG0601	transmembrane transport
TD69_RS01255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TD69_RS01260	COG0444	Belongs to the ABC transporter superfamily
TD69_RS01265	COG4608	Belongs to the ABC transporter superfamily
TD69_RS01290	COG3185	4-Hydroxyphenylpyruvate dioxygenase
TD69_RS01295	COG0179	Fumarylacetoacetate (FAA) hydrolase
TD69_RS01305	COG2814	Major facilitator Superfamily
TD69_RS01320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TD69_RS01330	COG4294	response to UV
TD69_RS01335	COG0457	Tetratricopeptide repeat
TD69_RS01335	COG0705	Rhomboid family
TD69_RS01345	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TD69_RS01350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TD69_RS01355	COG0864	Transcriptional regulator
TD69_RS01360	COG2337	Toxic component of a toxin-antitoxin (TA) module
TD69_RS01365	COG2183	response to ionizing radiation
TD69_RS01460	COG0802	atpase or kinase
TD69_RS01465	COG1214	PFAM Peptidase M22, glycoprotease
TD69_RS01470	COG0456	acetyltransferase
TD69_RS01480	COG0488	(ABC) transporter
TD69_RS01495	COG1266	CAAX protease self-immunity
TD69_RS01515	COG2252	PERMEase
TD69_RS01525	COG5002	protein histidine kinase activity
TD69_RS01555	COG2226	methyltransferase
TD69_RS01595	COG1968	undecaprenyl-diphosphatase activity
TD69_RS01610	COG2205	protein histidine kinase activity
TD69_RS01615	COG0745	RESPONSE REGULATOR receiver
TD69_RS01635	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TD69_RS01640	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TD69_RS01645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TD69_RS01655	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TD69_RS01670	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TD69_RS01680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TD69_RS01690	COG0151	Belongs to the GarS family
TD69_RS01715	COG0210	DNA helicase
TD69_RS01725	COG4851	CamS sex pheromone cAM373 precursor
TD69_RS01745	COG1335	isochorismatase
TD69_RS01750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TD69_RS01755	COG2011	ABC-type metal ion transport system permease component
TD69_RS01760	COG1464	Belongs to the NlpA lipoprotein family
TD69_RS01780	COG1846	Transcriptional regulator
TD69_RS01805	COG1597	lipid kinase activity
TD69_RS01810	COG0546	phosphoglycolate phosphatase activity
TD69_RS01815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TD69_RS01825	COG1012	belongs to the aldehyde dehydrogenase family
TD69_RS01830	COG2076	Multidrug Resistance protein
TD69_RS01835	COG2309	aminopeptidase activity
TD69_RS01850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TD69_RS01855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TD69_RS01860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TD69_RS01870	COG4807	Protein conserved in bacteria
TD69_RS01895	COG1757	Na H antiporter
TD69_RS01900	COG1473	amidohydrolase
TD69_RS01915	COG0450	alkyl hydroperoxide reductase
TD69_RS01935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TD69_RS01940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TD69_RS01945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TD69_RS01965	COG0166	Belongs to the GPI family
TD69_RS02000	COG5002	protein histidine kinase activity
TD69_RS02020	COG3541	Predicted nucleotidyltransferase
TD69_RS02025	COG2814	Major facilitator Superfamily
TD69_RS02030	COG0723	plastoquinol--plastocyanin reductase activity
TD69_RS02030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TD69_RS02040	COG0765	amino acid transport
TD69_RS02045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TD69_RS02060	COG0840	transmembrane signaling receptor activity
TD69_RS02065	COG0840	transmembrane signaling receptor activity
TD69_RS02070	COG0366	Alpha amylase catalytic
TD69_RS02075	COG1263	PTS System
TD69_RS02075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TD69_RS02075	COG2190	(PTS) system
TD69_RS02105	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
TD69_RS02120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TD69_RS02130	COG1116	anion transmembrane transporter activity
TD69_RS02135	COG0488	(ABC) transporter
TD69_RS02180	COG2270	Major facilitator Superfamily
TD69_RS02195	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TD69_RS02210	COG2310	stress, protein
TD69_RS02215	COG2310	stress, protein
TD69_RS02220	COG2310	stress, protein
TD69_RS02225	COG0861	Integral membrane protein TerC family
TD69_RS02235	COG3853	Toxic anion resistance protein (TelA)
TD69_RS02250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TD69_RS02260	COG1295	ribonuclease BN
TD69_RS02265	COG2217	Heavy metal translocating P-type atpase
TD69_RS02270	COG0697	spore germination
TD69_RS02290	COG0586	Pfam SNARE associated Golgi protein
TD69_RS02305	COG3871	stress protein (general stress protein 26)
TD69_RS02310	COG0387	Pfam Sodium calcium exchanger
TD69_RS02320	COG0535	radical SAM domain protein
TD69_RS02345	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TD69_RS02350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TD69_RS02355	COG0582	viral genome integration into host DNA
TD69_RS02360	COG1396	sequence-specific DNA binding
TD69_RS02375	COG1396	sequence-specific DNA binding
TD69_RS02410	COG1484	DNA-dependent DNA replication
TD69_RS02505	COG0582	viral genome integration into host DNA
TD69_RS02510	COG0582	viral genome integration into host DNA
TD69_RS02635	COG0101	tRNA pseudouridine synthase activity
TD69_RS02645	COG3829	transcription factor binding
TD69_RS02655	COG0833	amino acid
TD69_RS02660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TD69_RS02695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TD69_RS02695	COG1263	PTS System
TD69_RS02700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TD69_RS02715	COG0463	Glycosyl transferase, family 2
TD69_RS02730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TD69_RS02730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TD69_RS02750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TD69_RS02770	COG1228	amidohydrolase
TD69_RS02775	COG1090	epimerase
TD69_RS02805	COG1988	membrane-bound metal-dependent
TD69_RS02810	COG1194	a g-specific adenine glycosylase
TD69_RS02835	COG1132	(ABC) transporter
TD69_RS02840	COG4129	membrane
TD69_RS02845	COG0070	glutamate synthase
TD69_RS02845	COG0069	glutamate synthase activity
TD69_RS02845	COG0067	glutamate synthase
TD69_RS02855	COG4555	ABC transporter
TD69_RS02875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TD69_RS02880	COG0735	belongs to the Fur family
TD69_RS02995	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TD69_RS03000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TD69_RS03010	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TD69_RS03020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TD69_RS03035	COG2766	serine protein kinase
TD69_RS03060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TD69_RS03070	COG1585	Membrane protein implicated in regulation of membrane protease activity
TD69_RS03075	COG2268	Band 7 protein
TD69_RS03085	COG3290	protein histidine kinase activity
TD69_RS03095	COG2851	Citrate transporter
TD69_RS03115	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
TD69_RS03120	COG3842	ATPase activity
TD69_RS03125	COG1175	transmembrane transport
TD69_RS03130	COG0395	ABC-type sugar transport system, permease component
TD69_RS03140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TD69_RS03145	COG0745	RESPONSE REGULATOR receiver
TD69_RS03150	COG5002	protein histidine kinase activity
TD69_RS03160	COG4990	cell redox homeostasis
TD69_RS03170	COG3290	protein histidine kinase activity
TD69_RS03175	COG4565	transcriptional regulatory protein
TD69_RS03180	COG3493	citrate carrier protein
TD69_RS03185	COG0281	malic enzyme
TD69_RS03200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TD69_RS03210	COG5002	protein histidine kinase activity
TD69_RS03215	COG0745	RESPONSE REGULATOR receiver
TD69_RS03225	COG0454	-acetyltransferase
TD69_RS03225	COG0456	acetyltransferase
TD69_RS03230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TD69_RS03235	COG3383	formate dehydrogenase (NAD+) activity
TD69_RS03240	COG2427	Protein of unknown function (DUF1641)
TD69_RS03255	COG0531	amino acid
TD69_RS03260	COG0640	Transcriptional regulator
TD69_RS03265	COG2217	Heavy metal translocating P-type atpase
TD69_RS03270	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TD69_RS03280	COG3227	Zinc metalloprotease (Elastase)
TD69_RS03300	COG2720	vancomycin resistance protein
TD69_RS03305	COG1316	TRANSCRIPTIONal
TD69_RS03310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TD69_RS03315	COG0346	lactoylglutathione lyase activity
TD69_RS03320	COG1253	flavin adenine dinucleotide binding
TD69_RS03325	COG1027	Aspartate ammonia-lyase
TD69_RS03330	COG1620	l-lactate permease
TD69_RS03345	COG3104	oligopeptide transport
TD69_RS03350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TD69_RS03355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TD69_RS03360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TD69_RS03370	COG2226	methyltransferase
TD69_RS03375	COG0156	8-amino-7-oxononanoate synthase activity
TD69_RS03380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TD69_RS03390	COG4548	von Willebrand factor, type A
TD69_RS03395	COG0714	Associated with various cellular activities
TD69_RS03400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TD69_RS03420	COG0531	amino acid
TD69_RS03425	COG2188	Transcriptional regulator
TD69_RS03430	COG1263	PTS System
TD69_RS03430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TD69_RS03435	COG0366	Alpha amylase catalytic
TD69_RS03450	COG0697	spore germination
TD69_RS03460	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TD69_RS03465	COG1115	amino acid carrier protein
TD69_RS03470	COG1126	abc transporter atp-binding protein
TD69_RS03475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TD69_RS03480	COG0765	amino acid transport
TD69_RS03485	COG0765	amino acid transport
TD69_RS03490	COG0833	amino acid
TD69_RS03515	COG2378	regulation of single-species biofilm formation
TD69_RS03520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TD69_RS03525	COG5002	protein histidine kinase activity
TD69_RS03540	COG0659	secondary active sulfate transmembrane transporter activity
TD69_RS03555	COG0747	negative chemotaxis
TD69_RS03565	COG0601	transmembrane transport
TD69_RS03570	COG4608	Belongs to the ABC transporter superfamily
TD69_RS03580	COG2271	Major facilitator Superfamily
TD69_RS03585	COG1846	Transcriptional regulator
TD69_RS03590	COG0477	Major facilitator Superfamily
TD69_RS03595	COG0477	Major facilitator Superfamily
TD69_RS03600	COG1609	Transcriptional regulator
TD69_RS03605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TD69_RS03620	COG1172	Belongs to the binding-protein-dependent transport system permease family
TD69_RS03625	COG1879	ABC-type sugar transport system periplasmic component
TD69_RS03650	COG1063	alcohol dehydrogenase
TD69_RS03665	COG3568	Endonuclease Exonuclease Phosphatase
TD69_RS03690	COG1968	undecaprenyl-diphosphatase activity
TD69_RS03695	COG0840	transmembrane signaling receptor activity
TD69_RS03700	COG1388	LysM domain
TD69_RS03700	COG3584	3D domain protein
TD69_RS03705	COG1476	TRANSCRIPTIONal
TD69_RS03720	COG3104	oligopeptide transport
TD69_RS03725	COG1114	Component of the transport system for branched-chain amino acids
TD69_RS03740	COG1113	amino acid transport
TD69_RS03745	COG2252	PERMEase
TD69_RS03770	COG0475	glutathione-regulated potassium exporter activity
TD69_RS03770	COG0569	domain protein
TD69_RS03785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TD69_RS03790	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TD69_RS03795	COG0833	amino acid
TD69_RS03800	COG4990	cell redox homeostasis
TD69_RS03815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TD69_RS03820	COG0697	spore germination
TD69_RS03825	COG0531	amino acid
TD69_RS03840	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TD69_RS03845	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TD69_RS03850	COG1918	ferrous iron import across plasma membrane
TD69_RS03850	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TD69_RS03855	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TD69_RS03860	COG0573	inorganic phosphate transmembrane transporter activity
TD69_RS03865	COG0581	inorganic phosphate transmembrane transporter activity
TD69_RS03875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TD69_RS03990	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
TD69_RS04015	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TD69_RS04020	COG1116	anion transmembrane transporter activity
TD69_RS04025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TD69_RS04030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TD69_RS04035	COG0352	thiamine-phosphate diphosphorylase activity
TD69_RS04040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TD69_RS04045	COG2104	thiamine diphosphate biosynthetic process
TD69_RS04055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TD69_RS04060	COG0351	phosphomethylpyrimidine kinase
TD69_RS04100	COG2205	protein histidine kinase activity
TD69_RS04105	COG2814	Major facilitator Superfamily
TD69_RS04110	COG1846	Transcriptional regulator
TD69_RS04125	COG2252	PERMEase
TD69_RS04130	COG1028	Short-chain dehydrogenase reductase Sdr
TD69_RS04145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TD69_RS04150	COG1621	beta-fructofuranosidase activity
TD69_RS04155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TD69_RS04155	COG1263	PTS System
TD69_RS04160	COG1609	Transcriptional regulator
TD69_RS04170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TD69_RS04175	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TD69_RS04215	COG0778	Nitroreductase
TD69_RS04220	COG2719	SpoVR family
TD69_RS04245	COG0446	pyridine nucleotide-disulphide oxidoreductase
TD69_RS04250	COG1937	Protein conserved in bacteria
TD69_RS04255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TD69_RS04255	COG0425	Belongs to the sulfur carrier protein TusA family
TD69_RS04260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TD69_RS04260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TD69_RS04265	COG0425	Belongs to the sulfur carrier protein TusA family
TD69_RS04270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TD69_RS04280	COG2210	Belongs to the sulfur carrier protein TusA family
TD69_RS04285	COG0730	response to heat
TD69_RS04295	COG1316	TRANSCRIPTIONal
TD69_RS04300	COG0604	alcohol dehydrogenase
TD69_RS04305	COG1283	sodium-dependent phosphate transmembrane transporter activity
TD69_RS04320	COG3711	transcriptional antiterminator
TD69_RS04320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TD69_RS04325	COG1447	Phosphotransferase system cellobiose-specific component IIA
TD69_RS04330	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TD69_RS04350	COG1388	LysM domain
TD69_RS04350	COG3584	3D domain protein
TD69_RS04355	COG0577	efflux transmembrane transporter activity
TD69_RS04360	COG1136	(ABC) transporter
TD69_RS04370	COG5522	Integral membrane protein (intg_mem_TP0381)
TD69_RS04385	COG1114	Component of the transport system for branched-chain amino acids
TD69_RS04390	COG3546	catalase activity
TD69_RS04425	COG0586	Pfam SNARE associated Golgi protein
TD69_RS04460	COG0531	amino acid
TD69_RS04465	COG0475	glutathione-regulated potassium exporter activity
TD69_RS04475	COG1737	Transcriptional regulator
TD69_RS04485	COG1263	PTS System
TD69_RS04485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TD69_RS04495	COG2259	Doxx family
TD69_RS04510	COG0697	spore germination
TD69_RS04515	COG1522	sequence-specific DNA binding
TD69_RS04530	COG2076	Multidrug Resistance protein
TD69_RS04535	COG1309	transcriptional regulator
TD69_RS04540	COG2814	Major facilitator Superfamily
TD69_RS04545	COG1733	regulation of RNA biosynthetic process
TD69_RS04555	COG2249	NAD(P)H dehydrogenase (quinone) activity
TD69_RS04560	COG4533	DNA binding
TD69_RS04565	COG2211	Major facilitator Superfamily
TD69_RS04575	COG0693	protein deglycase activity
TD69_RS04580	COG0753	catalase activity
TD69_RS04580	COG0693	protein deglycase activity
TD69_RS04590	COG0531	amino acid
TD69_RS04595	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TD69_RS04605	COG1012	belongs to the aldehyde dehydrogenase family
TD69_RS04615	COG1132	(ABC) transporter
TD69_RS04625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TD69_RS04630	COG0765	amino acid transport
TD69_RS04635	COG1126	abc transporter atp-binding protein
TD69_RS04650	COG0189	ligase activity
TD69_RS04680	COG0028	Belongs to the TPP enzyme family
TD69_RS04685	COG3527	Alpha-acetolactate decarboxylase
TD69_RS04700	COG0561	phosphatase activity
TD69_RS04715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TD69_RS04730	COG0659	secondary active sulfate transmembrane transporter activity
TD69_RS04750	COG0653	protein targeting
TD69_RS04755	COG2244	polysaccharide biosynthetic process
TD69_RS04765	COG0860	N-Acetylmuramoyl-L-alanine amidase
TD69_RS04770	COG4196	transglutaminase domain protein
TD69_RS04785	COG1696	Membrane protein involved in D-alanine export
TD69_RS04800	COG1024	Enoyl-CoA hydratase
TD69_RS04820	COG1363	Peptidase, m42
TD69_RS04840	COG3938	Belongs to the proline racemase family
TD69_RS04880	COG0601	transmembrane transport
TD69_RS04885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TD69_RS04895	COG4608	Belongs to the ABC transporter superfamily
TD69_RS04925	COG0477	Major facilitator Superfamily
TD69_RS04930	COG3290	protein histidine kinase activity
TD69_RS04935	COG4565	transcriptional regulatory protein
TD69_RS04940	COG3181	Tripartite tricarboxylate transporter family receptor
TD69_RS04970	COG4978	Transcriptional regulator
TD69_RS04970	COG0789	Transcriptional regulator
TD69_RS04985	COG0305	Participates in initiation and elongation during chromosome replication
TD69_RS05025	COG0477	Major facilitator Superfamily
TD69_RS05075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TD69_RS05075	COG3320	Male sterility
TD69_RS05080	COG1309	transcriptional regulator
TD69_RS05100	COG1183	phosphatidylcholine synthase activity
TD69_RS05120	COG2376	Dihydroxyacetone kinase
TD69_RS05135	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TD69_RS05140	COG1959	2 iron, 2 sulfur cluster binding
TD69_RS05165	COG3437	response regulator, receiver
TD69_RS05165	COG2770	Histidine kinase
TD69_RS05215	COG3237	CsbD-like
TD69_RS05240	COG1191	sigma factor activity
TD69_RS05250	COG2208	phosphoserine phosphatase activity
TD69_RS05255	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TD69_RS05260	COG0784	Response regulator, receiver
TD69_RS05260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TD69_RS05260	COG2198	Histidine kinase
TD69_RS05260	COG2205	protein histidine kinase activity
TD69_RS05320	COG0420	3'-5' exonuclease activity
TD69_RS05325	COG4717	serine-type aminopeptidase activity
TD69_RS05345	COG1309	transcriptional regulator
TD69_RS05350	COG2814	Major facilitator Superfamily
TD69_RS05355	COG0346	lactoylglutathione lyase activity
TD69_RS05360	COG0346	lactoylglutathione lyase activity
TD69_RS05365	COG0457	Tetratricopeptide repeat
TD69_RS05370	COG2267	carboxylic ester hydrolase activity
TD69_RS05390	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
TD69_RS05395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TD69_RS05405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TD69_RS05445	COG0477	Major facilitator Superfamily
TD69_RS05450	COG0477	Major facilitator Superfamily
TD69_RS05460	COG3973	AAA domain
TD69_RS05465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TD69_RS05490	COG4980	gas vesicle protein
TD69_RS05495	COG0537	adenosine 5'-monophosphoramidase activity
TD69_RS05500	COG1131	(ABC) transporter
TD69_RS05505	COG4473	ABC transporter
TD69_RS05515	COG1309	transcriptional regulator
TD69_RS05525	COG3402	PFAM membrane-flanked domain
TD69_RS05535	COG3428	Bacterial PH domain
TD69_RS05580	COG3402	PFAM membrane-flanked domain
TD69_RS05585	COG3428	Bacterial PH domain
TD69_RS05590	COG2329	Antibiotic biosynthesis monooxygenase
TD69_RS05595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TD69_RS05600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TD69_RS05605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TD69_RS05610	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TD69_RS05645	COG1309	transcriptional regulator
TD69_RS05650	COG1511	domain protein
TD69_RS05675	COG1609	Transcriptional regulator
TD69_RS05685	COG1234	tRNA 3'-trailer cleavage
TD69_RS05690	COG0095	Lipoate-protein ligase
TD69_RS05700	COG0318	PFAM AMP-dependent synthetase and ligase
TD69_RS05730	COG3209	COG3209 Rhs family protein
TD69_RS05775	COG1408	metallophosphoesterase
TD69_RS05780	COG1078	dGTPase activity
TD69_RS05790	COG1595	DNA-templated transcription, initiation
TD69_RS05795	COG3708	Transcriptional regulator
TD69_RS05795	COG2207	Transcriptional regulator
TD69_RS05810	COG2205	protein histidine kinase activity
TD69_RS05815	COG0745	RESPONSE REGULATOR receiver
TD69_RS05840	COG0501	Belongs to the peptidase M48B family
TD69_RS05845	COG0840	transmembrane signaling receptor activity
TD69_RS05850	COG0697	spore germination
TD69_RS05870	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TD69_RS05875	COG2224	Isocitrate lyase
TD69_RS05900	COG4903	ComK protein
TD69_RS05905	COG0398	Pfam SNARE associated Golgi protein
TD69_RS05915	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
TD69_RS05920	COG1074	ATP-dependent DNA helicase activity
TD69_RS05965	COG0179	Fumarylacetoacetate (FAA) hydrolase
TD69_RS05990	COG0367	asparagine synthase
TD69_RS05995	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TD69_RS06000	COG0753	catalase activity
TD69_RS06030	COG2996	Protein conserved in bacteria
TD69_RS06040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TD69_RS06050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TD69_RS06065	COG0561	phosphatase activity
TD69_RS06080	COG0542	response to heat
TD69_RS06090	COG2267	carboxylic ester hydrolase activity
TD69_RS06105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TD69_RS06110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TD69_RS06115	COG5504	Zn-dependent protease
TD69_RS06125	COG0180	Tryptophanyl-tRNA synthetase
TD69_RS06135	COG4166	transmembrane transport
TD69_RS06140	COG0601	transmembrane transport
TD69_RS06145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TD69_RS06150	COG0444	Belongs to the ABC transporter superfamily
TD69_RS06155	COG4608	Belongs to the ABC transporter superfamily
TD69_RS06160	COG0534	Mate efflux family protein
TD69_RS06165	COG4166	transmembrane transport
TD69_RS06185	COG0861	Integral membrane protein TerC family
TD69_RS06190	COG4862	establishment of competence for transformation
TD69_RS06195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TD69_RS06205	COG1164	Oligoendopeptidase f
TD69_RS06215	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TD69_RS06220	COG2346	COG2346, Truncated hemoglobins
TD69_RS06225	COG4116	CYTH
TD69_RS06235	COG2357	RelA SpoT domain protein
TD69_RS06245	COG0564	pseudouridine synthase activity
TD69_RS06260	COG0772	Belongs to the SEDS family
TD69_RS06265	COG0463	Glycosyl transferase, family 2
TD69_RS06265	COG1216	Glycosyl transferase, family 2
TD69_RS06285	COG0457	Tetratricopeptide repeat
TD69_RS06285	COG0463	Glycosyl transferase, family 2
TD69_RS06305	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TD69_RS06320	COG1091	dTDP-4-dehydrorhamnose reductase activity
TD69_RS06365	COG2153	protein acetylation
TD69_RS06375	COG2382	esterase
TD69_RS06390	COG5492	domain, Protein
TD69_RS06395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TD69_RS06410	COG0512	Glutamine amidotransferase of anthranilate synthase
TD69_RS06410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TD69_RS06445	COG1620	l-lactate permease
TD69_RS06450	COG5634	Uncharacterized conserved protein (DUF2278)
TD69_RS06500	COG0508	dehydrogenase complex catalyzes the overall conversion of
TD69_RS06510	COG1476	TRANSCRIPTIONal
TD69_RS06570	COG2226	methyltransferase
TD69_RS06580	COG1686	Belongs to the peptidase S11 family
TD69_RS06585	COG0681	Belongs to the peptidase S26 family
TD69_RS06620	COG1012	belongs to the aldehyde dehydrogenase family
TD69_RS06625	COG3842	ATPase activity
TD69_RS06630	COG1176	ABC-type spermidine putrescine transport system, permease component I
TD69_RS06635	COG1177	transmembrane transport
TD69_RS06640	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TD69_RS06650	COG2409	Drug exporters of the RND superfamily
TD69_RS06660	COG0564	pseudouridine synthase activity
TD69_RS06670	COG2340	Cysteine-rich secretory protein family
TD69_RS06675	COG0247	lactate metabolic process
TD69_RS06680	COG0277	FAD linked oxidase domain protein
TD69_RS06685	COG3835	regulator
TD69_RS06695	COG0745	RESPONSE REGULATOR receiver
TD69_RS06700	COG5002	protein histidine kinase activity
TD69_RS06705	COG2186	Transcriptional regulator
TD69_RS06725	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TD69_RS06735	COG2116	formate transmembrane transporter activity
TD69_RS06740	COG0861	Integral membrane protein TerC family
TD69_RS06745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TD69_RS06755	COG2030	dehydratase
TD69_RS06775	COG1028	Short-chain dehydrogenase reductase Sdr
TD69_RS06780	COG3243	poly(R)-hydroxyalkanoic acid synthase
TD69_RS06785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TD69_RS06790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TD69_RS06805	COG1840	ABC-type Fe3 transport system, periplasmic component
TD69_RS06835	COG1349	DNA-binding transcription factor activity
TD69_RS06860	COG2861	carbohydrate metabolic process
TD69_RS06870	COG3852	Histidine kinase
TD69_RS06875	COG1846	Transcriptional regulator
TD69_RS06885	COG2318	DinB family
TD69_RS06895	COG5002	protein histidine kinase activity
TD69_RS06905	COG0720	synthase
TD69_RS06920	COG4873	Protein conserved in bacteria
TD69_RS06955	COG1780	Probably involved in ribonucleotide reductase function
TD69_RS06970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TD69_RS06975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TD69_RS06980	COG1725	Transcriptional regulator
TD69_RS06985	COG1131	(ABC) transporter
TD69_RS06995	COG1131	(ABC) transporter
TD69_RS07000	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
TD69_RS07015	COG1522	sequence-specific DNA binding
TD69_RS07025	COG1335	isochorismatase
TD69_RS07035	COG1619	proteins homologs of microcin C7 resistance protein MccF
TD69_RS07040	COG2070	2-Nitropropane dioxygenase
TD69_RS07045	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
TD69_RS07055	COG1696	Membrane protein involved in D-alanine export
TD69_RS07080	COG0716	FMN binding
TD69_RS07095	COG3173	Aminoglycoside phosphotransferase
TD69_RS07115	COG0534	Mate efflux family protein
TD69_RS07120	COG1968	undecaprenyl-diphosphatase activity
TD69_RS07135	COG1846	Transcriptional regulator
TD69_RS07145	COG1301	dicarboxylic acid transport
TD69_RS07150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TD69_RS07155	COG4709	membrane
TD69_RS07160	COG3874	Sporulation protein YtfJ
TD69_RS07190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TD69_RS07195	COG0028	Belongs to the TPP enzyme family
TD69_RS07200	COG0440	acetolactate synthase activity
TD69_RS07205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TD69_RS07215	COG0473	3-isopropylmalate dehydrogenase activity
TD69_RS07240	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TD69_RS07275	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TD69_RS07290	COG1183	phosphatidylcholine synthase activity
TD69_RS07295	COG1368	sulfuric ester hydrolase activity
TD69_RS07305	COG0019	diaminopimelate decarboxylase activity
TD69_RS07325	COG0529	Catalyzes the synthesis of activated sulfate
TD69_RS07330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TD69_RS07350	COG1648	precorrin-2 dehydrogenase activity
TD69_RS07360	COG0733	neurotransmitter:sodium symporter activity
TD69_RS07380	COG1757	Na H antiporter
TD69_RS07395	COG4758	membrane
TD69_RS07400	COG4585	Histidine kinase
TD69_RS07405	COG2197	response regulator
TD69_RS07415	COG1114	Component of the transport system for branched-chain amino acids
TD69_RS07425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TD69_RS07450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TD69_RS07450	COG1017	nitric oxide dioxygenase activity
TD69_RS07470	COG0730	response to heat
TD69_RS07475	COG0306	phosphate transporter
TD69_RS07480	COG1392	Phosphate transport regulator
TD69_RS07485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TD69_RS07500	COG3852	Histidine kinase
TD69_RS07505	COG1801	Protein of unknown function DUF72
TD69_RS07515	COG0582	viral genome integration into host DNA
TD69_RS07520	COG5002	protein histidine kinase activity
TD69_RS07540	COG0392	lysyltransferase activity
TD69_RS07540	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TD69_RS07555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TD69_RS07560	COG1686	Belongs to the peptidase S11 family
TD69_RS07565	COG2715	membrane protein required for spore maturation
TD69_RS07570	COG0700	Nucleoside recognition
TD69_RS07575	COG1187	pseudouridine synthase activity
TD69_RS07585	COG1333	cytochrome c biogenesis protein
TD69_RS07590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TD69_RS07595	COG0745	RESPONSE REGULATOR receiver
TD69_RS07600	COG5002	protein histidine kinase activity
TD69_RS07605	COG2096	Adenosyltransferase
TD69_RS07620	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
TD69_RS07625	COG1141	Ferredoxin
TD69_RS07630	COG4955	Helix-turn-helix domain
TD69_RS07635	COG0514	ATP-dependent DNA helicase (RecQ)
TD69_RS07640	COG1266	CAAX protease self-immunity
TD69_RS07660	COG4862	establishment of competence for transformation
TD69_RS07665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TD69_RS07685	COG0492	ferredoxin-NADP+ reductase activity
TD69_RS07690	COG0252	asparaginase activity
TD69_RS07760	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TD69_RS07775	COG0142	geranyltranstransferase activity
TD69_RS07785	COG0142	geranyltranstransferase activity
TD69_RS07805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TD69_RS07810	COG0457	Tetratricopeptide repeat
TD69_RS07830	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TD69_RS07840	COG4347	Protein of unknown function (DUF1405)
TD69_RS07855	COG2738	Putative neutral zinc metallopeptidase
TD69_RS07865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TD69_RS07870	COG1694	Mazg nucleotide pyrophosphohydrolase
TD69_RS07885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TD69_RS07890	COG0438	transferase activity, transferring glycosyl groups
TD69_RS07930	COG1199	ATP-dependent helicase activity
TD69_RS07930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TD69_RS07950	COG3935	DnaD domain protein
TD69_RS07955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TD69_RS07965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TD69_RS07965	COG4499	WXG100 protein secretion system (Wss), protein YukC
TD69_RS08015	COG0116	Belongs to the methyltransferase superfamily
TD69_RS08025	COG1199	ATP-dependent helicase activity
TD69_RS08030	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TD69_RS08040	COG3173	Aminoglycoside phosphotransferase
TD69_RS08045	COG0024	Methionine aminopeptidase
TD69_RS08055	COG2233	PERMEase
TD69_RS08060	COG2311	Membrane
TD69_RS08065	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TD69_RS08075	COG0456	acetyltransferase
TD69_RS08100	COG0754	glutathionylspermidine amidase activity
TD69_RS08115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TD69_RS08140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TD69_RS08155	COG1215	transferase activity, transferring glycosyl groups
TD69_RS08175	COG0454	-acetyltransferase
TD69_RS08195	COG0328	RNA-DNA hybrid ribonuclease activity
TD69_RS08235	COG1280	lysine exporter protein (LysE YggA)
TD69_RS08250	COG3162	membrane
TD69_RS08255	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TD69_RS08260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TD69_RS08270	COG0475	glutathione-regulated potassium exporter activity
TD69_RS08280	COG4978	Transcriptional regulator
TD69_RS08280	COG0789	Transcriptional regulator
TD69_RS08290	COG2323	membrane
TD69_RS08295	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TD69_RS08350	COG1923	regulation of RNA biosynthetic process
TD69_RS08360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TD69_RS08365	COG1360	Flagellar Motor Protein
TD69_RS08370	COG2201	protein-glutamate methylesterase activity
TD69_RS08380	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TD69_RS08380	COG1776	CheC inhibitor of MCP methylation
TD69_RS08395	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TD69_RS08415	COG1256	bacterial-type flagellum assembly
TD69_RS08420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TD69_RS08445	COG1815	bacterial-type flagellum-dependent cell motility
TD69_RS08450	COG1558	bacterial-type flagellum-dependent cell motility
TD69_RS08460	COG1766	The M ring may be actively involved in energy transduction
TD69_RS08470	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TD69_RS08480	COG1157	protein secretion by the type III secretion system
TD69_RS08530	COG0463	Glycosyl transferase, family 2
TD69_RS08560	COG0463	Glycosyl transferase, family 2
TD69_RS08560	COG0457	Tetratricopeptide repeat
TD69_RS08585	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TD69_RS08590	COG0741	lytic transglycosylase activity
TD69_RS08605	COG1776	CheC inhibitor of MCP methylation
TD69_RS08605	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TD69_RS08615	COG1338	Plays a role in the flagellum-specific transport system
TD69_RS08620	COG1987	bacterial-type flagellum assembly
TD69_RS08630	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TD69_RS08635	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TD69_RS08645	COG4786	Flagellar basal body rod
TD69_RS08650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TD69_RS08675	COG1309	transcriptional regulator
TD69_RS08695	COG2329	Antibiotic biosynthesis monooxygenase
TD69_RS08720	COG0583	DNA-binding transcription factor activity
TD69_RS08725	COG3842	ATPase activity
TD69_RS08730	COG0725	ABC transporter, periplasmic molybdate-binding protein
TD69_RS08740	COG1234	tRNA 3'-trailer cleavage
TD69_RS08765	COG1686	Belongs to the peptidase S11 family
TD69_RS08775	COG0406	alpha-ribazole phosphatase activity
TD69_RS08805	COG0367	asparagine synthase
TD69_RS08835	COG1802	Transcriptional regulator
TD69_RS08840	COG0697	spore germination
TD69_RS08845	COG0523	cobalamin synthesis protein
TD69_RS08850	COG0701	Predicted permease
TD69_RS08860	COG1216	Glycosyl transferase, family 2
TD69_RS08860	COG0438	transferase activity, transferring glycosyl groups
TD69_RS08865	COG1757	Na H antiporter
TD69_RS08870	COG0114	fumarate hydratase activity
TD69_RS08900	COG3340	Belongs to the peptidase S51 family
TD69_RS08920	COG0785	Cytochrome C biogenesis protein
TD69_RS08955	COG2733	membrane
TD69_RS08990	COG1131	(ABC) transporter
TD69_RS09005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TD69_RS09010	COG0528	UMP kinase activity
TD69_RS09020	COG1027	Aspartate ammonia-lyase
TD69_RS09025	COG0281	malic enzyme
TD69_RS09030	COG4191	Histidine kinase
TD69_RS09035	COG0784	Response regulator, receiver
TD69_RS09040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TD69_RS09100	COG1051	belongs to the nudix hydrolase family
TD69_RS09105	COG0860	N-Acetylmuramoyl-L-alanine amidase
TD69_RS09115	COG2814	Major facilitator Superfamily
TD69_RS09130	COG1966	Carbon starvation protein
TD69_RS09145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TD69_RS09155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TD69_RS09165	COG4166	transmembrane transport
TD69_RS09170	COG2223	nitrite transmembrane transporter activity
TD69_RS09175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TD69_RS09190	COG2244	polysaccharide biosynthetic process
TD69_RS09195	COG0733	neurotransmitter:sodium symporter activity
TD69_RS09205	COG5566	PFAM Mor transcription activator
TD69_RS09210	COG2323	membrane
TD69_RS09225	COG2084	Dehydrogenase
TD69_RS09240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TD69_RS09250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TD69_RS09255	COG0028	Belongs to the TPP enzyme family
TD69_RS09260	COG0440	acetolactate synthase activity
TD69_RS09265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TD69_RS09275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TD69_RS09300	COG2814	Major facilitator Superfamily
TD69_RS09305	COG3384	dioxygenase
TD69_RS09315	COG3279	Response regulator of the LytR AlgR family
TD69_RS09320	COG0427	acetyl-CoA hydrolase
TD69_RS09340	COG1073	alpha beta
TD69_RS09345	COG4166	transmembrane transport
TD69_RS09370	COG0535	radical SAM domain protein
TD69_RS09375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TD69_RS09395	COG1914	H( )-stimulated, divalent metal cation uptake system
TD69_RS09410	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TD69_RS09445	COG2390	Transcriptional regulator
TD69_RS09455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TD69_RS09460	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TD69_RS09475	COG4224	UPF0291 protein
TD69_RS09495	COG0006	proline dipeptidase activity
TD69_RS09500	COG2132	Multicopper oxidase
TD69_RS09515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TD69_RS09530	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TD69_RS09545	COG1276	copper resistance
TD69_RS09545	COG2372	response to copper ion
TD69_RS09550	COG4549	nuclear export factor GLE1
TD69_RS09560	COG0697	spore germination
TD69_RS09565	COG0583	DNA-binding transcription factor activity
TD69_RS09570	COG1959	2 iron, 2 sulfur cluster binding
TD69_RS09575	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TD69_RS09580	COG0778	Nitroreductase
TD69_RS09595	COG0628	permease
TD69_RS09605	COG1231	oxidoreductase activity
TD69_RS09610	COG0523	cobalamin synthesis protein
TD69_RS09625	COG0318	PFAM AMP-dependent synthetase and ligase
TD69_RS09630	COG2030	dehydratase
TD69_RS09635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TD69_RS09645	COG0411	ABC transporter
TD69_RS09665	COG0583	DNA-binding transcription factor activity
TD69_RS09675	COG1942	4-Oxalocrotonate Tautomerase
TD69_RS09685	COG1846	Transcriptional regulator
TD69_RS09695	COG1271	oxidase subunit
TD69_RS09700	COG1294	oxidase, subunit
TD69_RS09705	COG4988	ABC transporter
TD69_RS09710	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TD69_RS09730	COG1686	Belongs to the peptidase S11 family
TD69_RS09745	COG1388	LysM domain
TD69_RS09745	COG0791	NLP P60 protein
TD69_RS09755	COG1132	(ABC) transporter
TD69_RS09760	COG1132	(ABC) transporter
TD69_RS09765	COG0745	RESPONSE REGULATOR receiver
TD69_RS09770	COG5002	protein histidine kinase activity
TD69_RS09780	COG0300	oxidoreductase activity
TD69_RS09815	COG0460	homoserine dehydrogenase
TD69_RS09840	COG1316	TRANSCRIPTIONal
TD69_RS09850	COG0745	RESPONSE REGULATOR receiver
TD69_RS09855	COG5002	protein histidine kinase activity
TD69_RS09870	COG1285	pathogenesis
TD69_RS09875	COG1247	-acetyltransferase
TD69_RS09895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TD69_RS09905	COG1082	Xylose isomerase domain protein TIM barrel
TD69_RS09920	COG1279	arginine transmembrane transporter activity
TD69_RS09930	COG1752	Esterase of the alpha-beta hydrolase superfamily
TD69_RS09970	COG2002	toxin-antitoxin pair type II binding
TD69_RS09975	COG1404	Belongs to the peptidase S8 family
TD69_RS09980	COG0640	Transcriptional regulator
TD69_RS09985	COG0667	Aldo Keto reductase
TD69_RS09990	COG2814	Major facilitator Superfamily
TD69_RS10015	COG0840	transmembrane signaling receptor activity
TD69_RS10035	COG3949	Membrane
TD69_RS10040	COG0783	Belongs to the Dps family
TD69_RS10055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TD69_RS10065	COG1231	oxidoreductase activity
TD69_RS10075	COG4989	oxidoreductase activity
TD69_RS10080	COG0523	cobalamin synthesis protein
TD69_RS10085	COG0456	acetyltransferase
TD69_RS10150	COG0803	Belongs to the bacterial solute-binding protein 9 family
TD69_RS10150	COG3443	Belongs to the bacterial solute-binding protein 9 family
TD69_RS10160	COG0702	epimerase
TD69_RS10170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TD69_RS10180	COG4166	transmembrane transport
TD69_RS10195	COG0406	alpha-ribazole phosphatase activity
TD69_RS10205	COG5337	Spore coat protein CotH
TD69_RS10210	COG1051	belongs to the nudix hydrolase family
TD69_RS10215	COG0586	Pfam SNARE associated Golgi protein
TD69_RS10220	COG2244	polysaccharide biosynthetic process
TD69_RS10230	COG0701	Predicted permease
TD69_RS10235	COG3689	TIGRFAM TIGR03943 family protein
TD69_RS10240	COG1607	acyl-coa hydrolase
TD69_RS10245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TD69_RS10260	COG0702	epimerase
TD69_RS10265	COG2839	Protein conserved in bacteria
TD69_RS10270	COG1253	flavin adenine dinucleotide binding
TD69_RS10285	COG1114	Component of the transport system for branched-chain amino acids
TD69_RS10290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TD69_RS10310	COG0860	N-Acetylmuramoyl-L-alanine amidase
TD69_RS10320	COG1876	peptidase activity
TD69_RS10330	COG0154	amidase activity
TD69_RS10335	COG2211	Major facilitator Superfamily
TD69_RS10355	COG0561	phosphatase activity
TD69_RS10365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TD69_RS10370	COG4106	trans-aconitate 2-methyltransferase activity
TD69_RS10385	COG1819	glycosyl
TD69_RS10390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TD69_RS10395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TD69_RS10420	COG0456	acetyltransferase
TD69_RS10470	COG3874	Sporulation protein YtfJ
TD69_RS10495	COG2226	methyltransferase
TD69_RS10515	COG1082	Xylose isomerase domain protein TIM barrel
TD69_RS10520	COG0346	lactoylglutathione lyase activity
TD69_RS10530	COG0604	alcohol dehydrogenase
TD69_RS10535	COG1595	DNA-templated transcription, initiation
TD69_RS10560	COG0386	Belongs to the glutathione peroxidase family
TD69_RS10565	COG1305	Transglutaminase-like
TD69_RS10570	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
TD69_RS10575	COG0714	Associated with various cellular activities
TD69_RS10590	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TD69_RS10595	COG1140	nitrate reductase beta subunit
TD69_RS10600	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
TD69_RS10605	COG2181	nitrate reductase activity
TD69_RS10625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TD69_RS10630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TD69_RS10635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TD69_RS10640	COG0303	'Molybdopterin
TD69_RS10645	COG0314	molybdopterin synthase activity
TD69_RS10655	COG2223	nitrite transmembrane transporter activity
TD69_RS10670	COG1648	precorrin-2 dehydrogenase activity
TD69_RS10680	COG1587	Uroporphyrinogen-III synthase
TD69_RS10680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TD69_RS10685	COG2146	nitrite reductase [NAD(P)H] activity
TD69_RS10690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TD69_RS10695	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
TD69_RS10730	COG2359	stage V sporulation protein S
TD69_RS10745	COG5632	N-Acetylmuramoyl-L-alanine amidase
TD69_RS10760	COG1418	mRNA catabolic process
TD69_RS10765	COG0488	(ABC) transporter
TD69_RS10780	COG0629	single-stranded DNA binding
TD69_RS10795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TD69_RS10800	COG1413	lyase activity
TD69_RS10815	COG2136	Putative SAM-dependent methyltransferase
TD69_RS10815	COG2521	methyltransferase
TD69_RS10820	COG0018	arginyl-trna synthetase
TD69_RS10845	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TD69_RS10860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TD69_RS10865	COG0017	Asparaginyl-tRNA synthetase
TD69_RS10885	COG1674	ftsk spoiiie
TD69_RS10980	COG1929	Belongs to the glycerate kinase type-1 family
TD69_RS10985	COG0471	metal ion transport
TD69_RS10990	COG0745	RESPONSE REGULATOR receiver
TD69_RS10995	COG3850	Histidine kinase
TD69_RS10995	COG5002	protein histidine kinase activity
TD69_RS11010	COG0733	neurotransmitter:sodium symporter activity
TD69_RS11035	COG2610	gluconate transmembrane transporter activity
TD69_RS11040	COG1454	alcohol dehydrogenase
TD69_RS11045	COG1794	racemase activity, acting on amino acids and derivatives
TD69_RS11055	COG0456	acetyltransferase
TD69_RS11070	COG1131	(ABC) transporter
TD69_RS11075	COG4473	ABC transporter
TD69_RS11085	COG0546	phosphoglycolate phosphatase activity
TD69_RS11105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TD69_RS11120	COG0768	penicillin binding
TD69_RS11125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TD69_RS11130	COG0204	Acyl-transferase
TD69_RS11135	COG1272	protein, Hemolysin III
TD69_RS11145	COG0805	protein transport
TD69_RS11155	COG1307	EDD domain protein, DegV family
TD69_RS11160	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TD69_RS11165	COG1999	signal sequence binding
TD69_RS11170	COG0071	Belongs to the small heat shock protein (HSP20) family
TD69_RS11175	COG0367	asparagine synthase
TD69_RS11195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TD69_RS11200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TD69_RS11235	COG0668	transmembrane transport
TD69_RS11240	COG4585	Histidine kinase
TD69_RS11240	COG2203	Gaf domain
TD69_RS11245	COG2197	response regulator
TD69_RS11255	COG1737	Transcriptional regulator
TD69_RS11260	COG1064	alcohol dehydrogenase
TD69_RS11290	COG1070	Carbohydrate kinase
TD69_RS11295	COG1070	Carbohydrate kinase
TD69_RS11325	COG1125	glycine betaine transport
TD69_RS11325	COG0517	IMP dehydrogenase activity
TD69_RS11330	COG1174	glycine betaine transport
TD69_RS11365	COG1253	flavin adenine dinucleotide binding
TD69_RS11370	COG1012	belongs to the aldehyde dehydrogenase family
TD69_RS11375	COG5506	Protein of unknown function (DUF1694)
TD69_RS11390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TD69_RS11395	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TD69_RS11400	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TD69_RS11405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TD69_RS11410	COG0456	acetyltransferase
TD69_RS11415	COG3829	transcription factor binding
TD69_RS11420	COG1509	lysine 2,3-aminomutase activity
TD69_RS11460	COG4326	sporulation control protein
TD69_RS11465	COG0671	phosphoesterase, PA-phosphatase related
TD69_RS11470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TD69_RS11475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TD69_RS11505	COG1715	Restriction endonuclease
TD69_RS11505	COG1787	Restriction endonuclease
TD69_RS11595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TD69_RS11635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TD69_RS11635	COG4499	WXG100 protein secretion system (Wss), protein YukC
TD69_RS11640	COG2814	Major facilitator Superfamily
TD69_RS11645	COG4841	protein insertion into membrane
TD69_RS11650	COG0372	Belongs to the citrate synthase family
TD69_RS11655	COG2079	MmgE PrpD family protein
TD69_RS11660	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TD69_RS11665	COG1960	acyl-CoA dehydrogenase activity
TD69_RS11670	COG2084	Dehydrogenase
TD69_RS11680	COG1280	lysine exporter protein (LysE YggA)
TD69_RS11685	COG1024	Enoyl-CoA hydratase
TD69_RS11700	COG0420	3'-5' exonuclease activity
TD69_RS11705	COG0419	ATPase involved in DNA repair
TD69_RS11735	COG2223	nitrite transmembrane transporter activity
TD69_RS11740	COG1028	Short-chain dehydrogenase reductase Sdr
TD69_RS11745	COG1169	isochorismate synthase
TD69_RS11750	COG1021	2,3-dihydroxybenzoate-AMP ligase
TD69_RS11755	COG3433	isochorismatase activity
TD69_RS11755	COG1535	isochorismatase
TD69_RS11760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TD69_RS11765	COG3251	PFAM MbtH domain protein
TD69_RS11770	COG2814	Major facilitator Superfamily
TD69_RS11785	COG0776	regulation of translation
TD69_RS11795	COG2318	DinB family
TD69_RS11805	COG1115	amino acid carrier protein
TD69_RS11825	COG2329	Antibiotic biosynthesis monooxygenase
TD69_RS11830	COG1187	pseudouridine synthase activity
TD69_RS11835	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TD69_RS11850	COG0596	Alpha beta hydrolase
TD69_RS11855	COG2814	Major facilitator Superfamily
TD69_RS11875	COG2226	methyltransferase
TD69_RS11920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TD69_RS11955	COG1247	-acetyltransferase
TD69_RS11985	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TD69_RS11995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TD69_RS12005	COG1278	Cold shock
TD69_RS12020	COG0010	Belongs to the arginase family
TD69_RS12025	COG0561	phosphatase activity
TD69_RS12070	COG0583	DNA-binding transcription factor activity
TD69_RS12075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TD69_RS12090	COG0583	DNA-binding transcription factor activity
TD69_RS12095	COG2258	MOSC domain
TD69_RS12110	COG1132	(ABC) transporter
TD69_RS12115	COG1132	(ABC) transporter
TD69_RS12135	COG1396	sequence-specific DNA binding
TD69_RS12160	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
TD69_RS12165	COG1595	DNA-templated transcription, initiation
TD69_RS12215	COG2971	BadF BadG BcrA BcrD
TD69_RS12220	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TD69_RS12225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TD69_RS12245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TD69_RS12275	COG1309	transcriptional regulator
TD69_RS12290	COG1136	(ABC) transporter
TD69_RS12290	COG0577	efflux transmembrane transporter activity
TD69_RS12295	COG3615	Tellurite resistance protein tehB
TD69_RS12295	COG0500	methyltransferase
TD69_RS12305	COG2226	methyltransferase
TD69_RS12310	COG3961	Belongs to the TPP enzyme family
TD69_RS12315	COG1846	Transcriptional regulator
TD69_RS12355	COG2195	Cleaves the N-terminal amino acid of tripeptides
TD69_RS12370	COG1595	DNA-templated transcription, initiation
TD69_RS12380	COG0768	penicillin binding
TD69_RS12390	COG2367	Beta-lactamase
TD69_RS12395	COG0671	phosphoesterase, PA-phosphatase related
TD69_RS12400	COG1609	Transcriptional regulator
TD69_RS12405	COG2814	Major facilitator Superfamily
TD69_RS12410	COG0673	inositol 2-dehydrogenase activity
TD69_RS12420	COG1012	belongs to the aldehyde dehydrogenase family
TD69_RS12435	COG0191	fructose-bisphosphate aldolase activity
TD69_RS12440	COG3718	enzyme involved in inositol metabolism
TD69_RS12470	COG0457	Tetratricopeptide repeat
TD69_RS12475	COG1476	TRANSCRIPTIONal
TD69_RS12490	COG1876	peptidase activity
TD69_RS12510	COG1309	transcriptional regulator
TD69_RS12515	COG0488	(ABC) transporter
TD69_RS12530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TD69_RS12540	COG1252	NADH dehydrogenase
TD69_RS12545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TD69_RS12560	COG1131	(ABC) transporter
TD69_RS12570	COG1309	transcriptional regulator
TD69_RS12585	COG1960	acyl-CoA dehydrogenase activity
TD69_RS12590	COG0439	Biotin carboxylase
TD69_RS12595	COG0511	ligase activity, forming carbon-carbon bonds
TD69_RS12600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TD69_RS12605	COG1024	Enoyl-CoA hydratase
TD69_RS12610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TD69_RS12615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TD69_RS12625	COG1247	-acetyltransferase
TD69_RS12630	COG0572	uridine kinase
TD69_RS12640	COG2318	DinB family
TD69_RS12645	COG1686	Belongs to the peptidase S11 family
TD69_RS12670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TD69_RS12710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TD69_RS12710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TD69_RS12735	COG2814	Major facilitator Superfamily
TD69_RS12755	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TD69_RS12775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TD69_RS12790	COG1063	alcohol dehydrogenase
TD69_RS12805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TD69_RS12810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TD69_RS12825	COG3773	Cell wall hydrolase
TD69_RS12835	COG0745	RESPONSE REGULATOR receiver
TD69_RS12865	COG1136	(ABC) transporter
TD69_RS12890	COG0460	homoserine dehydrogenase
TD69_RS12895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TD69_RS12905	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TD69_RS12980	COG2124	cytochrome p450
TD69_RS13015	COG0561	phosphatase activity
TD69_RS13025	COG5002	protein histidine kinase activity
TD69_RS13030	COG0768	penicillin binding
TD69_RS13035	COG1819	glycosyl
TD69_RS13040	COG1794	racemase activity, acting on amino acids and derivatives
TD69_RS13050	COG1122	ATPase activity
TD69_RS13060	COG2205	protein histidine kinase activity
TD69_RS13070	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TD69_RS13075	COG0604	alcohol dehydrogenase
TD69_RS13080	COG0768	penicillin binding
TD69_RS13090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TD69_RS13125	COG0693	protein deglycase activity
TD69_RS13155	COG2814	Major facilitator Superfamily
TD69_RS13170	COG0584	glycerophosphoryl diester phosphodiesterase
TD69_RS13190	COG0697	spore germination
TD69_RS13215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TD69_RS13225	COG2223	nitrite transmembrane transporter activity
TD69_RS13240	COG2816	NAD+ diphosphatase activity
TD69_RS13245	COG0592	DNA-directed DNA polymerase activity
TD69_RS13250	COG1051	belongs to the nudix hydrolase family
TD69_RS13285	COG3878	Protein conserved in bacteria
TD69_RS13315	COG4667	esterase of the alpha-beta hydrolase superfamily
TD69_RS13340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TD69_RS13355	COG0322	excinuclease ABC activity
TD69_RS13395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TD69_RS13420	COG1011	Hydrolase
TD69_RS13440	COG0076	glutamate decarboxylase activity
TD69_RS13455	COG1523	belongs to the glycosyl hydrolase 13 family
TD69_RS13460	COG3227	Zinc metalloprotease (Elastase)
TD69_RS13480	COG0201	protein transport
TD69_RS13490	COG0697	spore germination
TD69_RS13495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TD69_RS13525	COG4129	membrane
TD69_RS13530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TD69_RS13545	COG2959	enzyme of heme biosynthesis
TD69_RS13565	COG3483	tryptophan 2,3-dioxygenase activity
TD69_RS13570	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TD69_RS13575	COG3844	kynureninase activity
TD69_RS13580	COG1309	transcriptional regulator
TD69_RS13610	COG3284	Transcriptional regulator
TD69_RS13630	COG1349	DNA-binding transcription factor activity
TD69_RS13650	COG1959	2 iron, 2 sulfur cluster binding
TD69_RS13665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TD69_RS13670	COG0508	dehydrogenase complex catalyzes the overall conversion of
TD69_RS13675	COG0022	dehydrogenase e1 component
TD69_RS13680	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TD69_RS13690	COG1028	Short-chain dehydrogenase reductase Sdr
TD69_RS13695	COG0456	acetyltransferase
TD69_RS13695	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TD69_RS13730	COG4176	ABC-type proline glycine betaine transport system permease component
TD69_RS13735	COG0517	IMP dehydrogenase activity
TD69_RS13735	COG4175	Glycine betaine
TD69_RS13760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TD69_RS13765	COG2153	protein acetylation
TD69_RS13770	COG3397	chitin binding
TD69_RS13785	COG2205	protein histidine kinase activity
TD69_RS13815	COG2333	competence protein COMEC
TD69_RS13815	COG0658	competence protein
TD69_RS13865	COG3973	AAA domain
TD69_RS13880	COG2105	PFAM AIG2 family protein
TD69_RS13885	COG0514	ATP-dependent DNA helicase (RecQ)
TD69_RS13915	COG4637	Psort location Cytoplasmic, score
TD69_RS13940	COG3397	chitin binding
TD69_RS13950	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TD69_RS13955	COG1115	amino acid carrier protein
TD69_RS13960	COG1012	belongs to the aldehyde dehydrogenase family
TD69_RS13965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TD69_RS13975	COG3938	Belongs to the proline racemase family
TD69_RS13980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TD69_RS14020	COG0586	Pfam SNARE associated Golgi protein
TD69_RS14035	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
TD69_RS14040	COG0519	Catalyzes the synthesis of GMP from XMP
TD69_RS14045	COG4166	transmembrane transport
TD69_RS14055	COG4948	Mandelate Racemase Muconate Lactonizing
TD69_RS14095	COG2936	dipeptidyl-peptidase activity
TD69_RS14100	COG5002	protein histidine kinase activity
TD69_RS14105	COG0745	RESPONSE REGULATOR receiver
TD69_RS14145	COG1307	EDD domain protein, DegV family
TD69_RS14165	COG2814	Major facilitator Superfamily
TD69_RS14175	COG1664	Polymer-forming cytoskeletal
TD69_RS14180	COG0789	Transcriptional regulator
TD69_RS14185	COG4533	DNA binding
TD69_RS14190	COG0477	Major facilitator Superfamily
TD69_RS14190	COG2814	Major facilitator Superfamily
TD69_RS14210	COG2261	transglycosylase associated protein
TD69_RS14225	COG2226	methyltransferase
TD69_RS14260	COG0436	Aminotransferase
TD69_RS14265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TD69_RS14270	COG5146	pantothenate kinase activity
TD69_RS14295	COG1131	(ABC) transporter
TD69_RS14345	COG0628	permease
TD69_RS14360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TD69_RS14365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TD69_RS14370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TD69_RS14375	COG1116	anion transmembrane transporter activity
TD69_RS14395	COG2816	NAD+ diphosphatase activity
TD69_RS14415	COG2746	aminoglycoside 3-N-acetyltransferase activity
TD69_RS14440	COG0697	spore germination
TD69_RS14445	COG2318	DinB family
TD69_RS14465	COG4912	Dna alkylation repair
TD69_RS14485	COG0861	Integral membrane protein TerC family
TD69_RS14490	COG1368	sulfuric ester hydrolase activity
TD69_RS14495	COG0488	(ABC) transporter
TD69_RS14505	COG2409	Drug exporters of the RND superfamily
TD69_RS14505	COG1033	growth of symbiont in host cell
TD69_RS14510	COG1033	growth of symbiont in host cell
TD69_RS14510	COG2409	Drug exporters of the RND superfamily
TD69_RS14515	COG1033	growth of symbiont in host cell
TD69_RS14515	COG2409	Drug exporters of the RND superfamily
TD69_RS14520	COG1309	transcriptional regulator
TD69_RS14535	COG0287	Prephenate dehydrogenase
TD69_RS14540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TD69_RS14545	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TD69_RS14550	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TD69_RS14550	COG1605	Chorismate mutase
TD69_RS14585	COG1388	LysM domain
TD69_RS14585	COG3584	3D domain protein
TD69_RS14595	COG1595	DNA-templated transcription, initiation
TD69_RS14620	COG1879	ABC-type sugar transport system periplasmic component
TD69_RS14630	COG1172	Belongs to the binding-protein-dependent transport system permease family
TD69_RS14640	COG2390	Transcriptional regulator
TD69_RS14675	COG2329	Antibiotic biosynthesis monooxygenase
TD69_RS14695	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TD69_RS14705	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TD69_RS14710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TD69_RS14715	COG4187	Peptidase family M20/M25/M40
TD69_RS14720	COG1414	Transcriptional regulator
TD69_RS14725	COG0833	amino acid
TD69_RS14730	COG1690	Belongs to the RtcB family
TD69_RS14735	COG3239	Fatty acid desaturase
TD69_RS14740	COG1785	Belongs to the alkaline phosphatase family
TD69_RS14750	COG3655	Transcriptional regulator
TD69_RS14765	COG4377	Putative membrane peptidase family (DUF2324)
TD69_RS14775	COG3279	Response regulator of the LytR AlgR family
TD69_RS14785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TD69_RS14790	COG0346	lactoylglutathione lyase activity
TD69_RS14810	COG0714	Associated with various cellular activities
TD69_RS14835	COG0463	Glycosyl transferase, family 2
TD69_RS14860	COG0463	Glycosyl transferase, family 2
TD69_RS14870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TD69_RS14875	COG0753	catalase activity
TD69_RS14885	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TD69_RS14910	COG0714	Associated with various cellular activities
TD69_RS14920	COG0778	Nitroreductase
TD69_RS14925	COG1846	Transcriptional regulator
TD69_RS14960	COG1725	Transcriptional regulator
TD69_RS14970	COG1136	(ABC) transporter
TD69_RS14970	COG0577	efflux transmembrane transporter activity
TD69_RS14995	COG2207	Transcriptional regulator
TD69_RS15000	COG0456	acetyltransferase
TD69_RS15020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TD69_RS15040	COG0642	Histidine kinase
TD69_RS15045	COG0745	RESPONSE REGULATOR receiver
TD69_RS15050	COG0596	Alpha beta hydrolase
TD69_RS15080	COG0730	response to heat
TD69_RS15090	COG0833	amino acid
TD69_RS15100	COG4335	DNA alkylation repair
TD69_RS15150	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TD69_RS15190	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TD69_RS15195	COG1414	Transcriptional regulator
TD69_RS15210	COG0860	N-Acetylmuramoyl-L-alanine amidase
TD69_RS15215	COG0640	Transcriptional regulator
TD69_RS15225	COG1960	acyl-CoA dehydrogenase activity
TD69_RS15245	COG3314	Sporulation integral membrane protein YlbJ
TD69_RS15260	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
TD69_RS15275	COG3848	Pyruvate phosphate dikinase
TD69_RS15275	COG0574	Belongs to the PEP-utilizing enzyme family
TD69_RS15280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TD69_RS15295	COG5577	PFAM Coat F domain
TD69_RS15300	COG3403	YqcI/YcgG family
TD69_RS15305	COG1280	lysine exporter protein (LysE YggA)
TD69_RS15340	COG1063	alcohol dehydrogenase
TD69_RS15355	COG1027	Aspartate ammonia-lyase
TD69_RS15360	COG0252	asparaginase activity
TD69_RS15365	COG1396	sequence-specific DNA binding
TD69_RS15375	COG0322	excinuclease ABC activity
TD69_RS15380	COG0531	amino acid
TD69_RS15385	COG1114	Component of the transport system for branched-chain amino acids
TD69_RS15390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TD69_RS15400	COG0281	malic enzyme
TD69_RS15425	COG0697	spore germination
TD69_RS15430	COG0784	Response regulator, receiver
TD69_RS15440	COG2066	Belongs to the glutaminase family
TD69_RS15470	COG0737	Belongs to the 5'-nucleotidase family
TD69_RS15475	COG0753	catalase activity
TD69_RS15480	COG2267	carboxylic ester hydrolase activity
TD69_RS15485	COG1335	isochorismatase
TD69_RS15510	COG0583	DNA-binding transcription factor activity
TD69_RS15555	COG0415	Belongs to the DNA photolyase family
TD69_RS15560	COG0288	reversible hydration of carbon dioxide
TD69_RS15570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TD69_RS15575	COG5609	conserved protein (DUF2294)
TD69_RS15585	COG1575	Belongs to the MenA family. Type 1 subfamily
TD69_RS15590	COG2267	carboxylic ester hydrolase activity
TD69_RS15595	COG0803	Belongs to the bacterial solute-binding protein 9 family
TD69_RS15600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TD69_RS15605	COG1121	(ABC) transporter
TD69_RS15635	COG0798	PFAM Bile acid sodium symporter
TD69_RS15640	COG0346	lactoylglutathione lyase activity
TD69_RS15645	COG0640	Transcriptional regulator
TD69_RS15660	COG0443	Heat shock 70 kDa protein
TD69_RS15675	COG1522	sequence-specific DNA binding
TD69_RS15690	COG0346	lactoylglutathione lyase activity
TD69_RS15715	COG2169	Transcriptional regulator
TD69_RS15760	COG2814	Major facilitator Superfamily
TD69_RS15785	COG0745	RESPONSE REGULATOR receiver
TD69_RS15790	COG3850	Histidine kinase
TD69_RS15790	COG5002	protein histidine kinase activity
TD69_RS15820	COG2515	1-aminocyclopropane-1-carboxylate deaminase
TD69_RS15845	COG1476	TRANSCRIPTIONal
TD69_RS15860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TD69_RS15865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TD69_RS15875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TD69_RS15880	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
TD69_RS15895	COG1136	(ABC) transporter
TD69_RS15900	COG0577	efflux transmembrane transporter activity
TD69_RS15920	COG5002	protein histidine kinase activity
TD69_RS15920	COG3850	Histidine kinase
TD69_RS15930	COG2364	Membrane
TD69_RS15935	COG1846	Transcriptional regulator
TD69_RS15945	COG2808	Putative FMN-binding domain
TD69_RS15950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TD69_RS15955	COG2271	Major facilitator Superfamily
TD69_RS15960	COG1556	Lactate utilization protein
TD69_RS15965	COG1139	Iron-sulfur cluster binding protein
TD69_RS15975	COG0583	DNA-binding transcription factor activity
TD69_RS15985	COG1619	proteins homologs of microcin C7 resistance protein MccF
TD69_RS16015	COG0738	Major facilitator superfamily
TD69_RS16020	COG0673	inositol 2-dehydrogenase activity
TD69_RS16025	COG0561	phosphatase activity
TD69_RS16035	COG1609	Transcriptional regulator
TD69_RS16040	COG0457	Tetratricopeptide repeat
TD69_RS16060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TD69_RS16090	COG0534	Mate efflux family protein
TD69_RS16105	COG2814	Major facilitator Superfamily
TD69_RS16110	COG1309	transcriptional regulator
TD69_RS16125	COG0814	amino acid
TD69_RS16130	COG1760	l-serine dehydratase
TD69_RS16135	COG1760	l-serine dehydratase
TD69_RS16145	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TD69_RS16150	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TD69_RS16160	COG1335	isochorismatase
TD69_RS16165	COG1522	sequence-specific DNA binding
TD69_RS16170	COG0531	amino acid
TD69_RS16185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TD69_RS16205	COG1595	DNA-templated transcription, initiation
TD69_RS16220	COG0662	Cupin 2, conserved barrel domain protein
TD69_RS16230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TD69_RS16230	COG2207	Transcriptional regulator
TD69_RS16285	COG0477	Major facilitator Superfamily
TD69_RS16295	COG1846	Transcriptional regulator
TD69_RS16300	COG2814	Major facilitator Superfamily
TD69_RS16315	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
TD69_RS16320	COG1131	(ABC) transporter
TD69_RS16340	COG2076	Multidrug Resistance protein
TD69_RS16345	COG1309	transcriptional regulator
TD69_RS16360	COG2031	fatty acid transporter
TD69_RS16370	COG2249	NAD(P)H dehydrogenase (quinone) activity
TD69_RS16400	COG1122	ATPase activity
TD69_RS16405	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TD69_RS16420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TD69_RS16425	COG1288	antiporter activity
TD69_RS16430	COG2356	endonuclease I
TD69_RS16445	COG3620	sequence-specific DNA binding
TD69_RS16450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TD69_RS16455	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TD69_RS16460	COG0124	histidyl-tRNA synthetase
TD69_RS16475	COG1733	regulation of RNA biosynthetic process
TD69_RS16480	COG0778	Nitroreductase
TD69_RS16500	COG1028	Short-chain dehydrogenase reductase Sdr
TD69_RS16510	COG1131	(ABC) transporter
TD69_RS16535	COG1011	Hydrolase
TD69_RS16545	COG2365	Tyrosine phosphatase family
TD69_RS16570	COG0346	lactoylglutathione lyase activity
TD69_RS16575	COG1940	carbohydrate kinase activity
TD69_RS16580	COG0738	Major facilitator superfamily
TD69_RS16585	COG0110	maltose O-acetyltransferase activity
TD69_RS16600	COG1136	(ABC) transporter
TD69_RS16600	COG0577	efflux transmembrane transporter activity
TD69_RS16610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TD69_RS16615	COG0628	permease
TD69_RS16635	COG2226	methyltransferase
TD69_RS16645	COG0477	Major facilitator Superfamily
TD69_RS16675	COG1253	flavin adenine dinucleotide binding
TD69_RS16680	COG0789	Transcriptional regulator
TD69_RS16685	COG0697	spore germination
TD69_RS16690	COG1357	PFAM Pentapeptide repeats (8 copies)
TD69_RS16695	COG3813	Protein conserved in bacteria
TD69_RS16700	COG2706	6-phosphogluconolactonase activity
TD69_RS16705	COG1070	Carbohydrate kinase
TD69_RS16715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TD69_RS16720	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TD69_RS16730	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TD69_RS16735	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TD69_RS16740	COG0604	alcohol dehydrogenase
TD69_RS16745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TD69_RS16755	COG3321	synthase
TD69_RS16755	COG0604	alcohol dehydrogenase
TD69_RS16765	COG1028	Short-chain dehydrogenase reductase Sdr
TD69_RS16790	COG0656	L-ascorbic acid biosynthetic process
TD69_RS16795	COG2814	Major facilitator Superfamily
TD69_RS16810	COG0346	lactoylglutathione lyase activity
TD69_RS16815	COG0814	amino acid
TD69_RS16840	COG1393	Belongs to the ArsC family
TD69_RS16850	COG1733	regulation of RNA biosynthetic process
TD69_RS16855	COG2188	Transcriptional regulator
TD69_RS16865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TD69_RS16870	COG1733	regulation of RNA biosynthetic process
TD69_RS16875	COG1733	regulation of RNA biosynthetic process
TD69_RS16890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TD69_RS16910	COG0384	phenazine biosynthesis protein PhzF
TD69_RS16920	COG1028	Short-chain dehydrogenase reductase Sdr
TD69_RS16930	COG0318	PFAM AMP-dependent synthetase and ligase
TD69_RS16940	COG1733	regulation of RNA biosynthetic process
TD69_RS16975	COG1191	sigma factor activity
TD69_RS16990	COG1309	transcriptional regulator
TD69_RS17010	COG3152	Membrane
TD69_RS17035	COG1151	hydroxylamine reductase activity
TD69_RS17045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TD69_RS17050	COG3409	Peptidoglycan-binding domain 1 protein
TD69_RS17050	COG3757	hydrolase, family 25
TD69_RS17085	COG2072	flavoprotein involved in K transport
TD69_RS17125	COG1113	amino acid transport
TD69_RS17130	COG2814	Major facilitator Superfamily
TD69_RS17165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TD69_RS17170	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TD69_RS17190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TD69_RS17200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TD69_RS17205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TD69_RS17210	COG3739	integral membrane protein
TD69_RS17215	COG0384	phenazine biosynthesis protein PhzF
TD69_RS17245	COG0583	DNA-binding transcription factor activity
TD69_RS17265	COG1193	negative regulation of DNA recombination
TD69_RS17280	COG2162	N-hydroxyarylamine O-acetyltransferase activity
TD69_RS17285	COG1164	Oligoendopeptidase f
TD69_RS17290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TD69_RS17320	COG0584	glycerophosphoryl diester phosphodiesterase
TD69_RS17345	COG0640	Transcriptional regulator
TD69_RS17350	COG0604	alcohol dehydrogenase
TD69_RS17370	COG2808	Putative FMN-binding domain
TD69_RS17375	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TD69_RS17385	COG0385	Bile acid
TD69_RS17390	COG0277	FAD linked oxidase domain protein
TD69_RS17425	COG1216	Glycosyl transferase, family 2
TD69_RS17430	COG1024	Enoyl-CoA hydratase
TD69_RS17440	COG1285	pathogenesis
TD69_RS17450	COG2514	catechol 2,3-dioxygenase activity
TD69_RS17455	COG2720	vancomycin resistance protein
TD69_RS17495	COG0716	FMN binding
TD69_RS17525	COG1028	Short-chain dehydrogenase reductase Sdr
TD69_RS17535	COG0165	Argininosuccinate lyase
TD69_RS17550	COG4145	pantothenate transmembrane transporter activity
TD69_RS17560	COG1012	belongs to the aldehyde dehydrogenase family
TD69_RS17565	COG1028	Short-chain dehydrogenase reductase Sdr
TD69_RS17575	COG1657	PFAM Prenyltransferase squalene oxidase
TD69_RS17580	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TD69_RS17585	COG2962	Rard protein
TD69_RS17590	COG3326	Membrane
TD69_RS17605	COG0489	protein tyrosine kinase activity
TD69_RS17615	COG0314	molybdopterin synthase activity
TD69_RS17620	COG0303	'Molybdopterin
TD69_RS17625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TD69_RS17630	COG2116	formate transmembrane transporter activity
TD69_RS17640	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TD69_RS17645	COG5609	conserved protein (DUF2294)
TD69_RS17650	COG2427	Protein of unknown function (DUF1641)
TD69_RS17655	COG3383	formate dehydrogenase (NAD+) activity
TD69_RS17665	COG0697	spore germination
TD69_RS17705	COG2226	methyltransferase
TD69_RS17710	COG4166	transmembrane transport
TD69_RS17715	COG4166	transmembrane transport
TD69_RS17730	COG1316	TRANSCRIPTIONal
TD69_RS17740	COG1595	DNA-templated transcription, initiation
TD69_RS17765	COG1131	(ABC) transporter
TD69_RS17775	COG0673	inositol 2-dehydrogenase activity
TD69_RS17780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TD69_RS17785	COG0187	DNA topoisomerase II activity
TD69_RS17795	COG1832	CoA-binding protein
TD69_RS17800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TD69_RS17805	COG0745	RESPONSE REGULATOR receiver
TD69_RS17820	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TD69_RS17825	COG4841	protein insertion into membrane
TD69_RS17830	COG0824	Thioesterase
TD69_RS17860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TD69_RS17870	COG2274	protein secretion by the type I secretion system
TD69_RS17875	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TD69_RS17905	COG2211	Major facilitator Superfamily
TD69_RS17915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TD69_RS17930	COG0183	Belongs to the thiolase family
TD69_RS17935	COG0318	PFAM AMP-dependent synthetase and ligase
TD69_RS17940	COG1268	BioY protein
TD69_RS17945	COG0318	PFAM AMP-dependent synthetase and ligase
TD69_RS17990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TD69_RS18000	COG5002	protein histidine kinase activity
TD69_RS18005	COG0400	carboxylic ester hydrolase activity
TD69_RS18010	COG0346	lactoylglutathione lyase activity
TD69_RS18015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TD69_RS18020	COG0069	glutamate synthase activity
TD69_RS18025	COG1902	pentaerythritol trinitrate reductase activity
TD69_RS18030	COG1329	Transcriptional regulator
TD69_RS18035	COG0010	Belongs to the arginase family
TD69_RS18060	COG2226	methyltransferase
TD69_RS18115	COG4846	Membrane protein involved in cytochrome C biogenesis
TD69_RS18120	COG0785	Cytochrome C biogenesis protein
TD69_RS18130	COG0583	DNA-binding transcription factor activity
TD69_RS18135	COG1380	Effector of murein hydrolase LrgA
TD69_RS18140	COG1346	cytolysis
TD69_RS18155	COG0730	response to heat
TD69_RS18165	COG3409	Peptidoglycan-binding domain 1 protein
TD69_RS18165	COG5632	N-Acetylmuramoyl-L-alanine amidase
TD69_RS18180	COG1132	(ABC) transporter
TD69_RS18185	COG1132	(ABC) transporter
TD69_RS18220	COG3639	organic phosphonate transmembrane transporter activity
TD69_RS18225	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TD69_RS18240	COG0737	Belongs to the 5'-nucleotidase family
TD69_RS18250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TD69_RS18270	COG1695	Transcriptional regulator
TD69_RS18305	COG1388	LysM domain
TD69_RS18305	COG3409	Peptidoglycan-binding domain 1 protein
TD69_RS18305	COG5632	N-Acetylmuramoyl-L-alanine amidase
TD69_RS18310	COG4824	toxin secretion phage lysis holin
TD69_RS18470	COG1595	DNA-templated transcription, initiation
TD69_RS18515	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TD69_RS18595	COG1396	sequence-specific DNA binding
TD69_RS18620	COG0174	glutamine synthetase
TD69_RS18625	COG0789	Transcriptional regulator
TD69_RS18630	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
TD69_RS18640	COG2860	membrane
TD69_RS18645	COG0464	growth
TD69_RS18675	COG1388	LysM domain
TD69_RS18675	COG3584	3D domain protein
TD69_RS18680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TD69_RS18680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TD69_RS18680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TD69_RS18685	COG1105	Belongs to the carbohydrate kinase PfkB family
TD69_RS18690	COG1349	DNA-binding transcription factor activity
TD69_RS18700	COG2322	membrane
TD69_RS18715	COG1113	amino acid transport
TD69_RS18725	COG1408	metallophosphoesterase
TD69_RS18730	COG2116	formate transmembrane transporter activity
TD69_RS18740	COG2217	Heavy metal translocating P-type atpase
TD69_RS18745	COG2608	mercury ion transmembrane transporter activity
TD69_RS18750	COG1937	Protein conserved in bacteria
TD69_RS18760	COG2819	hydrolase of the alpha beta superfamily
TD69_RS18765	COG1120	ATPase activity
TD69_RS18770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TD69_RS18775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TD69_RS18780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TD69_RS18790	COG0708	Exodeoxyribonuclease III
TD69_RS18795	COG2169	Transcriptional regulator
TD69_RS18800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TD69_RS18805	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TD69_RS18815	COG2364	Membrane
TD69_RS18830	COG2267	carboxylic ester hydrolase activity
TD69_RS18835	COG0346	lactoylglutathione lyase activity
TD69_RS18840	COG5001	Diguanylate cyclase
TD69_RS18840	COG3300	MHYT domain
TD69_RS18860	COG1346	cytolysis
TD69_RS18865	COG1380	Effector of murein hydrolase LrgA
TD69_RS18870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TD69_RS18875	COG0596	Alpha beta hydrolase
TD69_RS18875	COG0508	dehydrogenase complex catalyzes the overall conversion of
TD69_RS18880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TD69_RS18895	COG1404	Belongs to the peptidase S8 family
TD69_RS18900	COG3773	Cell wall hydrolase
TD69_RS18905	COG0562	UDP-galactopyranose mutase
TD69_RS18910	COG1368	sulfuric ester hydrolase activity
TD69_RS18915	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TD69_RS18925	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
TD69_RS18950	COG1131	(ABC) transporter
TD69_RS18970	COG4550	Control of competence regulator ComK, YlbF/YmcA
TD69_RS18975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TD69_RS18980	COG1013	pyruvate-flavodoxin oxidoreductase activity
TD69_RS18985	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TD69_RS18985	COG0674	pyruvate-flavodoxin oxidoreductase activity
TD69_RS18995	COG2359	stage V sporulation protein S
TD69_RS19000	COG1692	metallophosphoesterase
TD69_RS19025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TD69_RS19030	COG1426	Protein conserved in bacteria
TD69_RS19045	COG0300	oxidoreductase activity
TD69_RS19050	COG0612	Peptidase, M16
TD69_RS19055	COG0612	Peptidase, M16
TD69_RS19065	COG4603	Belongs to the binding-protein-dependent transport system permease family
TD69_RS19070	COG4603	Belongs to the binding-protein-dependent transport system permease family
TD69_RS19075	COG3845	ABC transporter
TD69_RS19080	COG1744	ABC transporter substrate-binding protein PnrA-like
TD69_RS19085	COG2188	Transcriptional regulator
TD69_RS19090	COG1674	ftsk spoiiie
TD69_RS19100	COG0740	serine-type endopeptidase activity
TD69_RS19105	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TD69_RS19120	COG0527	aspartate kinase activity
TD69_RS19125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TD69_RS19130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TD69_RS19135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TD69_RS19140	COG1873	PFAM PRC-barrel domain
TD69_RS19145	COG0612	Peptidase, M16
TD69_RS19150	COG0726	polysaccharide deacetylase
TD69_RS19165	COG0196	riboflavin kinase activity
TD69_RS19170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TD69_RS19180	COG1550	Protein conserved in bacteria
TD69_RS19190	COG1358	cellular component organization or biogenesis
TD69_RS19195	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TD69_RS19200	COG0195	Participates in both transcription termination and antitermination
TD69_RS19220	COG0750	zinc metalloprotease
TD69_RS19230	COG4589	Belongs to the CDS family
TD69_RS19235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TD69_RS19245	COG0528	UMP kinase activity
TD69_RS19275	COG4974	Belongs to the 'phage' integrase family
TD69_RS19285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TD69_RS19295	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TD69_RS19335	COG1837	Belongs to the UPF0109 family
TD69_RS19345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TD69_RS19355	COG0552	protein localization to endoplasmic reticulum
TD69_RS19360	COG1196	nuclear chromosome segregation
TD69_RS19370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TD69_RS19375	COG1028	Short-chain dehydrogenase reductase Sdr
TD69_RS19380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TD69_RS19395	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TD69_RS19400	COG1461	Dihydroxyacetone kinase
TD69_RS19405	COG1302	Protein conserved in bacteria
TD69_RS19420	COG1564	THIamine pyrophosphokinase
TD69_RS19425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TD69_RS19430	COG1162	GTPase activity
TD69_RS19435	COG0515	serine threonine protein kinase
TD69_RS19435	COG2815	serine threonine protein kinase
TD69_RS19440	COG0631	protein serine/threonine phosphatase activity
TD69_RS19450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TD69_RS19450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TD69_RS19460	COG0242	peptide deformylase activity
TD69_RS19465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TD69_RS19470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TD69_RS19490	COG1561	YicC-like family, N-terminal region
TD69_RS19495	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TD69_RS19505	COG0006	proline dipeptidase activity
TD69_RS19520	COG3069	C4-dicarboxylate transmembrane transporter activity
TD69_RS19585	COG0564	pseudouridine synthase activity
TD69_RS19605	COG3599	regulation of cell shape
TD69_RS19610	COG2302	S4 RNA-binding domain
TD69_RS19615	COG0762	integral membrane protein
TD69_RS19625	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TD69_RS19630	COG1496	oxidoreductase activity
TD69_RS19635	COG1873	PFAM PRC-barrel domain
TD69_RS19640	COG1191	sigma factor activity
TD69_RS19645	COG1191	sigma factor activity
TD69_RS19655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TD69_RS19660	COG0849	cell division
TD69_RS19665	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TD69_RS19670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TD69_RS19680	COG0772	Belongs to the SEDS family
TD69_RS19695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TD69_RS19700	COG0768	penicillin binding
TD69_RS19705	COG0768	penicillin binding
TD69_RS19710	COG4839	cell division protein FtsL
TD69_RS19725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TD69_RS19740	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TD69_RS19745	COG1399	metal-binding, possibly nucleic acid-binding protein
TD69_RS19795	COG4824	toxin secretion phage lysis holin
TD69_RS19890	COG1802	Transcriptional regulator
TD69_RS19890	COG4626	Terminase
TD69_RS19915	COG0582	viral genome integration into host DNA
TD69_RS19985	COG0756	dUTP diphosphatase activity
TD69_RS19995	COG1191	sigma factor activity
TD69_RS20020	COG1484	DNA-dependent DNA replication
TD69_RS20050	COG1396	sequence-specific DNA binding
TD69_RS20060	COG1396	sequence-specific DNA binding
TD69_RS20075	COG0582	viral genome integration into host DNA
TD69_RS20085	COG3480	Lon protease (S16) C-terminal proteolytic domain
TD69_RS20090	COG1752	Esterase of the alpha-beta hydrolase superfamily
TD69_RS20095	COG3314	Sporulation integral membrane protein YlbJ
TD69_RS20105	COG0742	ribosomal rna small subunit methyltransferase
TD69_RS20120	COG3679	Belongs to the UPF0342 family
TD69_RS20125	COG0406	alpha-ribazole phosphatase activity
TD69_RS20140	COG2340	Cysteine-rich secretory protein family
TD69_RS20155	COG3336	cytochrome c oxidase
TD69_RS20190	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TD69_RS20195	COG0772	Belongs to the SEDS family
TD69_RS20205	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TD69_RS20210	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TD69_RS20220	COG4896	Protein conserved in bacteria
TD69_RS20235	COG1217	gtp-binding protein TYPA
TD69_RS20245	COG0483	inositol monophosphate 1-phosphatase activity
TD69_RS20265	COG1982	Orn Lys Arg decarboxylase major
TD69_RS20310	COG0508	dehydrogenase complex catalyzes the overall conversion of
TD69_RS20315	COG0022	dehydrogenase e1 component
TD69_RS20320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TD69_RS20330	COG0242	peptide deformylase activity
TD69_RS20335	COG0561	phosphatase activity
TD69_RS20345	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TD69_RS20350	COG0569	domain protein
TD69_RS20370	COG0583	DNA-binding transcription factor activity
TD69_RS20375	COG0517	IMP dehydrogenase activity
TD69_RS20385	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TD69_RS20395	COG4703	Protein of unknown function (DUF1797)
TD69_RS20410	COG2200	EAL domain
TD69_RS20415	COG1028	Short-chain dehydrogenase reductase Sdr
TD69_RS20420	COG1408	metallophosphoesterase
TD69_RS20430	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TD69_RS20470	COG2814	Major facilitator Superfamily
TD69_RS20495	COG3209	COG3209 Rhs family protein
TD69_RS20505	COG2205	protein histidine kinase activity
TD69_RS20515	COG0436	Aminotransferase
TD69_RS20520	COG1609	Transcriptional regulator
TD69_RS20525	COG3833	ABC-type maltose transport systems, permease component
TD69_RS20530	COG1175	transmembrane transport
TD69_RS20535	COG2182	Extracellular solute-binding protein
TD69_RS20545	COG0366	Alpha amylase catalytic
TD69_RS20550	COG3842	ATPase activity
TD69_RS20590	COG0183	Belongs to the thiolase family
TD69_RS20630	COG1695	Transcriptional regulator
TD69_RS20635	COG1028	Short-chain dehydrogenase reductase Sdr
TD69_RS20645	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TD69_RS20655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TD69_RS20660	COG0436	Aminotransferase
TD69_RS20680	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TD69_RS20700	COG2199	diguanylate cyclase activity
TD69_RS20705	COG0778	Nitroreductase
TD69_RS20730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TD69_RS20730	COG1263	PTS System
TD69_RS20730	COG2190	(PTS) system
TD69_RS20735	COG3711	transcriptional antiterminator
TD69_RS20745	COG2188	Transcriptional regulator
TD69_RS20755	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TD69_RS20785	COG1547	Domain of unknown function (DUF309)
TD69_RS20790	COG0456	acetyltransferase
TD69_RS20800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TD69_RS20805	COG4086	secreted protein
TD69_RS20810	COG0561	phosphatase activity
TD69_RS20815	COG0697	spore germination
TD69_RS20830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TD69_RS20855	COG0733	neurotransmitter:sodium symporter activity
TD69_RS20875	COG1686	Belongs to the peptidase S11 family
TD69_RS20880	COG1725	Transcriptional regulator
TD69_RS20885	COG1131	(ABC) transporter
TD69_RS20905	COG1846	Transcriptional regulator
TD69_RS20920	COG0598	Magnesium transport protein CorA
TD69_RS20945	COG4974	Belongs to the 'phage' integrase family
TD69_RS20955	COG0735	belongs to the Fur family
TD69_RS20960	COG1300	Membrane
TD69_RS20980	COG0667	Aldo Keto reductase
TD69_RS20985	COG0656	L-ascorbic acid biosynthetic process
TD69_RS20990	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TD69_RS20990	COG0456	acetyltransferase
TD69_RS21000	COG1525	nuclease
TD69_RS21000	COG4085	toxin activity
TD69_RS21000	COG0737	Belongs to the 5'-nucleotidase family
TD69_RS21010	COG0596	Alpha beta hydrolase
TD69_RS21015	COG2056	Na+-H+ antiporter family
TD69_RS21020	COG1609	Transcriptional regulator
TD69_RS21025	COG0456	acetyltransferase
TD69_RS21030	COG1073	alpha beta
TD69_RS21045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TD69_RS21045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TD69_RS21050	COG0307	riboflavin synthase, alpha
TD69_RS21075	COG4106	trans-aconitate 2-methyltransferase activity
TD69_RS21080	COG1073	alpha beta
TD69_RS21080	COG2226	methyltransferase
TD69_RS21095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TD69_RS21105	COG1757	Na H antiporter
TD69_RS21110	COG0737	Belongs to the 5'-nucleotidase family
TD69_RS21120	COG1522	sequence-specific DNA binding
TD69_RS21140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TD69_RS21150	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TD69_RS21165	COG0300	oxidoreductase activity
TD69_RS21170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TD69_RS21180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TD69_RS21185	COG1760	l-serine dehydratase
TD69_RS21190	COG1760	l-serine dehydratase
TD69_RS21210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TD69_RS21220	COG2195	Cleaves the N-terminal amino acid of tripeptides
TD69_RS21225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TD69_RS21240	COG1376	ErfK ybiS ycfS ynhG family protein
TD69_RS21245	COG4129	membrane
TD69_RS21250	COG1126	abc transporter atp-binding protein
TD69_RS21255	COG0765	amino acid transport
TD69_RS21260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TD69_RS21285	COG0772	Belongs to the SEDS family
TD69_RS21295	COG0508	dehydrogenase complex catalyzes the overall conversion of
TD69_RS21300	COG0022	dehydrogenase e1 component
TD69_RS21305	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TD69_RS21310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TD69_RS21325	COG0280	phosphate acetyltransferase
TD69_RS21335	COG3829	transcription factor binding
TD69_RS21335	COG3290	protein histidine kinase activity
TD69_RS21345	COG0584	glycerophosphoryl diester phosphodiesterase
TD69_RS21350	COG3093	addiction module antidote protein HigA
TD69_RS21360	COG0745	RESPONSE REGULATOR receiver
TD69_RS21365	COG0750	zinc metalloprotease
TD69_RS21370	COG0497	DNA recombination
TD69_RS21380	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TD69_RS21390	COG0142	geranyltranstransferase activity
TD69_RS21415	COG1302	Protein conserved in bacteria
TD69_RS21420	COG0439	Biotin carboxylase
TD69_RS21425	COG0511	ligase activity, forming carbon-carbon bonds
TD69_RS21470	COG3854	ATPases associated with a variety of cellular activities
TD69_RS21495	COG0006	proline dipeptidase activity
TD69_RS21510	COG3872	metal-dependent enzyme
TD69_RS21520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TD69_RS21540	COG0095	Lipoate-protein ligase
TD69_RS21545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TD69_RS21550	COG1609	Transcriptional regulator
TD69_RS21560	COG2076	Multidrug Resistance protein
TD69_RS21565	COG2076	Multidrug Resistance protein
TD69_RS21605	COG1131	(ABC) transporter
TD69_RS21610	COG1725	Transcriptional regulator
TD69_RS21640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TD69_RS21695	COG4970	Tfp pilus assembly protein FimT
TD69_RS21705	COG1459	type II secretion system
TD69_RS21710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TD69_RS21760	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TD69_RS21765	COG0646	methionine synthase
TD69_RS21765	COG1410	methionine synthase
TD69_RS21770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TD69_RS21770	COG0646	methionine synthase
TD69_RS21780	COG0626	cystathionine gamma-synthase activity
TD69_RS21785	COG0626	cystathionine gamma-synthase activity
TD69_RS21810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TD69_RS21820	COG1940	carbohydrate kinase activity
TD69_RS21825	COG4483	Protein conserved in bacteria
TD69_RS21830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TD69_RS21835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TD69_RS21840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TD69_RS21845	COG0704	Plays a role in the regulation of phosphate uptake
TD69_RS21855	COG0581	inorganic phosphate transmembrane transporter activity
TD69_RS21860	COG0573	inorganic phosphate transmembrane transporter activity
TD69_RS21865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TD69_RS21870	COG0768	penicillin binding
TD69_RS21875	COG0477	Major facilitator Superfamily
TD69_RS21880	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TD69_RS21905	COG0735	belongs to the Fur family
TD69_RS21910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TD69_RS21915	COG1121	(ABC) transporter
TD69_RS21920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TD69_RS21950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TD69_RS21955	COG2384	SAM-dependent methyltransferase
TD69_RS21960	COG2010	Cytochrome c
TD69_RS21965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TD69_RS21970	COG0358	DNA primase activity
TD69_RS21990	COG0517	IMP dehydrogenase activity
TD69_RS22005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TD69_RS22010	COG0295	cytidine deaminase activity
TD69_RS22015	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TD69_RS22025	COG1480	7TM receptor with intracellular HD hydrolase
TD69_RS22030	COG1702	phosphate starvation-inducible protein PhoH
TD69_RS22050	COG1610	YqeY-like protein
TD69_RS22055	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TD69_RS22060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TD69_RS22065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TD69_RS22095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TD69_RS22100	COG1733	regulation of RNA biosynthetic process
TD69_RS22125	COG1466	dna polymerase III delta subunit
TD69_RS22135	COG2333	competence protein COMEC
TD69_RS22135	COG0658	competence protein
TD69_RS22140	COG2131	deaminase
TD69_RS22145	COG1555	photosystem II stabilization
TD69_RS22145	COG1596	polysaccharide export
TD69_RS22150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TD69_RS22155	COG2226	methyltransferase
TD69_RS22160	COG0799	negative regulation of ribosome biogenesis
TD69_RS22165	COG1713	HD superfamily hydrolase involved in NAD metabolism
TD69_RS22175	COG1534	Rna-binding protein
TD69_RS22185	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TD69_RS22190	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TD69_RS22215	COG1595	DNA-templated transcription, initiation
TD69_RS22225	COG0778	Nitroreductase
TD69_RS22230	COG2357	RelA SpoT domain protein
TD69_RS22240	COG1785	Belongs to the alkaline phosphatase family
TD69_RS22250	COG2267	carboxylic ester hydrolase activity
TD69_RS22285	COG1404	Belongs to the peptidase S8 family
TD69_RS22290	COG3186	Phenylalanine-4-hydroxylase
TD69_RS22300	COG2514	catechol 2,3-dioxygenase activity
TD69_RS22305	COG2514	catechol 2,3-dioxygenase activity
TD69_RS22310	COG2259	Doxx family
TD69_RS22350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TD69_RS22360	COG1454	alcohol dehydrogenase
TD69_RS22360	COG1012	belongs to the aldehyde dehydrogenase family
TD69_RS22365	COG0626	cystathionine gamma-synthase activity
TD69_RS22370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TD69_RS22395	COG0768	penicillin binding
TD69_RS22410	COG0826	peptidase U32
TD69_RS22415	COG0826	peptidase U32
TD69_RS22420	COG4122	O-methyltransferase activity
TD69_RS22425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TD69_RS22445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TD69_RS22455	COG0628	permease
TD69_RS22475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TD69_RS22485	COG0482	sulfurtransferase activity
TD69_RS22490	COG1104	cysteine desulfurase activity
TD69_RS22495	COG1959	2 iron, 2 sulfur cluster binding
TD69_RS22500	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TD69_RS22510	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TD69_RS22535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TD69_RS22545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TD69_RS22545	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TD69_RS22550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TD69_RS22555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TD69_RS22555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TD69_RS22565	COG2244	polysaccharide biosynthetic process
TD69_RS22570	COG2323	membrane
TD69_RS22580	COG1862	Preprotein translocase
TD69_RS22610	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
TD69_RS22620	COG0697	spore germination
TD69_RS22625	COG0697	spore germination
TD69_RS22630	COG0640	Transcriptional regulator
TD69_RS22655	COG0157	Belongs to the NadC ModD family
TD69_RS22660	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TD69_RS22665	COG1104	cysteine desulfurase activity
TD69_RS22670	COG1827	regulation of RNA biosynthetic process
TD69_RS22675	COG2258	MOSC domain
TD69_RS22680	COG0077	Prephenate dehydratase
TD69_RS22685	COG0577	efflux transmembrane transporter activity
TD69_RS22690	COG0577	efflux transmembrane transporter activity
TD69_RS22695	COG1136	(ABC) transporter
TD69_RS22700	COG5002	protein histidine kinase activity
TD69_RS22710	COG0745	RESPONSE REGULATOR receiver
TD69_RS22715	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TD69_RS22720	COG3290	protein histidine kinase activity
TD69_RS22730	COG2868	ribosomal protein
TD69_RS22740	COG1530	ribonuclease E activity
TD69_RS22745	COG1994	Peptidase M50
TD69_RS22750	COG0739	heme binding
TD69_RS22755	COG2894	cell division
TD69_RS22775	COG1077	Cell shape determining protein MreB Mrl
TD69_RS22795	COG0285	dihydrofolate synthase activity
TD69_RS22800	COG0525	valine-tRNA ligase activity
TD69_RS22810	COG1388	LysM domain
TD69_RS22820	COG0113	porphobilinogen synthase activity
TD69_RS22825	COG1587	Uroporphyrinogen-III synthase
TD69_RS22835	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TD69_RS22845	COG1846	Transcriptional regulator
TD69_RS22850	COG1764	response to oxidative stress
TD69_RS22865	COG1067	ATP-dependent peptidase activity
TD69_RS22865	COG0470	DNA polymerase III
TD69_RS22915	COG0622	Phosphoesterase
TD69_RS22930	COG5401	PFAM Sporulation and spore germination
TD69_RS22950	COG1309	transcriptional regulator
TD69_RS22965	COG2197	response regulator
TD69_RS22970	COG2233	PERMEase
TD69_RS22980	COG0402	S-adenosylhomocysteine deaminase activity
TD69_RS22985	COG0402	S-adenosylhomocysteine deaminase activity
TD69_RS22995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TD69_RS23005	COG0444	Belongs to the ABC transporter superfamily
TD69_RS23010	COG4608	Belongs to the ABC transporter superfamily
TD69_RS23015	COG3275	phosphorelay sensor kinase activity
TD69_RS23020	COG3279	Response regulator of the LytR AlgR family
TD69_RS23035	COG1983	PspC domain protein
TD69_RS23040	COG1396	sequence-specific DNA binding
TD69_RS23045	COG0697	spore germination
TD69_RS23055	COG1959	2 iron, 2 sulfur cluster binding
TD69_RS23060	COG1668	transmembrane transport
TD69_RS23065	COG4152	abc transporter atp-binding protein
TD69_RS23070	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
TD69_RS23080	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TD69_RS23085	COG1876	peptidase activity
TD69_RS23090	COG0824	Thioesterase
TD69_RS23095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TD69_RS23100	COG1053	succinate dehydrogenase
TD69_RS23105	COG2009	succinate dehydrogenase
TD69_RS23110	COG1719	4-vinyl reductase, 4VR
TD69_RS23120	COG3118	belongs to the thioredoxin family
TD69_RS23125	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TD69_RS23130	COG2086	electron transfer activity
TD69_RS23135	COG1024	Enoyl-CoA hydratase
TD69_RS23140	COG1309	transcriptional regulator
TD69_RS23145	COG0318	PFAM AMP-dependent synthetase and ligase
TD69_RS23165	COG2318	DinB family
TD69_RS23195	COG1131	(ABC) transporter
TD69_RS23200	COG2205	protein histidine kinase activity
TD69_RS23205	COG0745	RESPONSE REGULATOR receiver
TD69_RS23215	COG4895	conserved protein (DUF2196)
TD69_RS23220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TD69_RS23235	COG4509	Sortase family
TD69_RS23240	COG1120	ATPase activity
TD69_RS23255	COG5386	Cell surface protein
TD69_RS23265	COG5386	Cell surface protein
TD69_RS23270	COG1114	Component of the transport system for branched-chain amino acids
TD69_RS23275	COG1187	pseudouridine synthase activity
TD69_RS23290	COG1796	DNA polymerase
TD69_RS23290	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TD69_RS23295	COG1286	toxin biosynthetic process
TD69_RS23340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TD69_RS23350	COG1418	mRNA catabolic process
TD69_RS23375	COG2814	Major facilitator Superfamily
TD69_RS23380	COG1566	PFAM secretion protein HlyD family protein
TD69_RS23385	COG1309	transcriptional regulator
TD69_RS23390	COG1363	Peptidase, m42
TD69_RS23415	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TD69_RS23425	COG1484	DNA-dependent DNA replication
TD69_RS23430	COG3611	Membrane attachment protein
TD69_RS23440	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TD69_RS23445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TD69_RS23450	COG0237	dephospho-CoA kinase activity
TD69_RS23455	COG1971	Probably functions as a manganese efflux pump
TD69_RS23465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TD69_RS23465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TD69_RS23470	COG5002	protein histidine kinase activity
TD69_RS23475	COG0745	RESPONSE REGULATOR receiver
TD69_RS23495	COG0538	isocitrate dehydrogenase activity
TD69_RS23500	COG0372	Belongs to the citrate synthase family
TD69_RS23515	COG0628	permease
TD69_RS23520	COG3030	protein affecting phage T7 exclusion by the F plasmid
TD69_RS23545	COG1725	Transcriptional regulator
TD69_RS23550	COG0281	malic enzyme
TD69_RS23555	COG0587	DNA-directed DNA polymerase activity
TD69_RS23570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TD69_RS23590	COG4109	DRTGG domain
TD69_RS23605	COG0006	proline dipeptidase activity
TD69_RS23640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TD69_RS23645	COG0662	Cupin 2, conserved barrel domain protein
TD69_RS23655	COG1476	TRANSCRIPTIONal
TD69_RS23670	COG1028	Short-chain dehydrogenase reductase Sdr
TD69_RS23675	COG0589	response to stress
TD69_RS23715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TD69_RS23735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TD69_RS23740	COG0827	DNA restriction-modification system
TD69_RS23745	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
TD69_RS23750	COG3874	Sporulation protein YtfJ
TD69_RS23765	COG1574	metal-dependent hydrolase with the TIM-barrel fold
TD69_RS23775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TD69_RS23790	COG1104	cysteine desulfurase activity
TD69_RS23800	COG0583	DNA-binding transcription factor activity
TD69_RS23805	COG0697	spore germination
TD69_RS23815	COG1956	GAF domain-containing protein
TD69_RS23820	COG0626	cystathionine gamma-synthase activity
TD69_RS23850	COG1595	DNA-templated transcription, initiation
TD69_RS23860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TD69_RS23865	COG0454	-acetyltransferase
TD69_RS23870	COG0517	IMP dehydrogenase activity
TD69_RS23875	COG0123	including yeast histone deacetylase and acetoin utilization protein
TD69_RS23885	COG0745	RESPONSE REGULATOR receiver
TD69_RS23895	COG0666	response to abiotic stimulus
TD69_RS23930	COG1609	Transcriptional regulator
TD69_RS23940	COG4851	CamS sex pheromone cAM373 precursor
TD69_RS23945	COG3118	belongs to the thioredoxin family
TD69_RS23955	COG2309	aminopeptidase activity
TD69_RS23975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TD69_RS23990	COG1674	ftsk spoiiie
TD69_RS24000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TD69_RS24005	COG4848	Belongs to the UPF0354 family
TD69_RS24010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TD69_RS24015	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
TD69_RS24020	COG1363	Peptidase, m42
TD69_RS24030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TD69_RS24045	COG0510	thiamine kinase activity
TD69_RS24050	COG1523	belongs to the glycosyl hydrolase 13 family
TD69_RS24065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TD69_RS24070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TD69_RS24075	COG1349	DNA-binding transcription factor activity
TD69_RS24080	COG1187	pseudouridine synthase activity
TD69_RS24085	COG2244	polysaccharide biosynthetic process
TD69_RS24090	COG2081	HI0933 family
TD69_RS24095	COG2814	Major facilitator Superfamily
TD69_RS24105	COG3832	glyoxalase III activity
TD69_RS24125	COG1329	Transcriptional regulator
TD69_RS24135	COG4975	Glucose uptake
TD69_RS24150	COG0314	molybdopterin synthase activity
TD69_RS24155	COG1763	Mo-molybdopterin cofactor biosynthetic process
TD69_RS24160	COG0303	'Molybdopterin
TD69_RS24170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TD69_RS24195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TD69_RS24205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TD69_RS24250	COG2814	Major facilitator Superfamily
TD69_RS24255	COG0475	glutathione-regulated potassium exporter activity
TD69_RS24260	COG0490	domain, Protein
TD69_RS24265	COG0582	viral genome integration into host DNA
TD69_RS24275	COG1136	(ABC) transporter
TD69_RS24295	COG1242	4 iron, 4 sulfur cluster binding
TD69_RS24300	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TD69_RS24305	COG1131	(ABC) transporter
TD69_RS24315	COG1794	racemase activity, acting on amino acids and derivatives
TD69_RS24335	COG2267	carboxylic ester hydrolase activity
TD69_RS24340	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TD69_RS24345	COG0671	phosphoesterase, PA-phosphatase related
TD69_RS24350	COG0438	transferase activity, transferring glycosyl groups
TD69_RS24360	COG0521	Mo-molybdopterin cofactor biosynthetic process
TD69_RS24415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TD69_RS24420	COG5002	protein histidine kinase activity
TD69_RS24425	COG4191	Histidine kinase
TD69_RS24430	COG2267	carboxylic ester hydrolase activity
TD69_RS24450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TD69_RS24455	COG1116	anion transmembrane transporter activity
TD69_RS24460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TD69_RS24485	COG0494	nUDIX hydrolase
TD69_RS24515	COG0288	reversible hydration of carbon dioxide
TD69_RS24520	COG1271	oxidase subunit
TD69_RS24525	COG1294	oxidase, subunit
TD69_RS24545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TD69_RS24570	COG1842	Phage shock protein A
TD69_RS24605	COG5002	protein histidine kinase activity
TD69_RS24610	COG0745	RESPONSE REGULATOR receiver
TD69_RS24640	COG1597	lipid kinase activity
TD69_RS24675	COG0586	Pfam SNARE associated Golgi protein
TD69_RS24685	COG0577	efflux transmembrane transporter activity
TD69_RS24690	COG1136	(ABC) transporter
TD69_RS24695	COG2207	Transcriptional regulator
TD69_RS24695	COG3708	Transcriptional regulator
TD69_RS24700	COG0745	RESPONSE REGULATOR receiver
TD69_RS24705	COG2205	protein histidine kinase activity
TD69_RS24710	COG0577	efflux transmembrane transporter activity
TD69_RS24720	COG0577	efflux transmembrane transporter activity
TD69_RS24725	COG0577	efflux transmembrane transporter activity
TD69_RS24730	COG1136	(ABC) transporter
TD69_RS24750	COG2188	Transcriptional regulator
TD69_RS24770	COG3964	amidohydrolase
TD69_RS24800	COG4948	Mandelate Racemase Muconate Lactonizing
TD69_RS24810	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TD69_RS24815	COG0596	Alpha beta hydrolase
TD69_RS24820	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TD69_RS24825	COG1169	isochorismate synthase
TD69_RS24830	COG1575	Belongs to the MenA family. Type 1 subfamily
TD69_RS24835	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TD69_RS24860	COG0058	SHG alpha-glucan phosphorylase activity
TD69_RS24865	COG0297	glycogen (starch) synthase activity
TD69_RS24870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TD69_RS24980	COG0544	peptidyl-prolyl cis-trans isomerase activity
TD69_RS25015	COG1285	pathogenesis
TD69_RS25020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TD69_RS25030	COG0166	Belongs to the GPI family
TD69_RS25040	COG2155	Conserved Protein
TD69_RS25045	COG1098	S1 RNA binding domain
TD69_RS25050	COG0436	Aminotransferase
TD69_RS25055	COG1522	sequence-specific DNA binding
TD69_RS25060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TD69_RS25065	COG2267	carboxylic ester hydrolase activity
TD69_RS25075	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TD69_RS25095	COG5018	Exonuclease
TD69_RS25100	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TD69_RS25120	COG2050	protein possibly involved in aromatic compounds catabolism
TD69_RS25130	COG1268	BioY protein
TD69_RS25140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TD69_RS25145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TD69_RS25160	COG3584	3D domain protein
TD69_RS25175	COG1252	NADH dehydrogenase
TD69_RS25190	COG3708	Transcriptional regulator
TD69_RS25205	COG1683	Conserved Protein
TD69_RS25225	COG0316	Belongs to the HesB IscA family
TD69_RS25240	COG1252	NADH dehydrogenase
TD69_RS25255	COG0390	transport system, permease component
TD69_RS25260	COG2824	Alkylphosphonate utilization operon protein PhnA
TD69_RS25300	COG4837	Protein of unknown function (DUF1462)
TD69_RS25305	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TD69_RS25315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TD69_RS25320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TD69_RS25335	COG2249	NAD(P)H dehydrogenase (quinone) activity
TD69_RS25340	COG0647	UMP catabolic process
TD69_RS25350	COG2445	Protein of unknown function DUF86
TD69_RS25355	COG1494	fructose-1,6-bisphosphatase
TD69_RS25375	COG4470	Protein conserved in bacteria
TD69_RS25385	COG0789	Transcriptional regulator
TD69_RS25390	COG4377	Putative membrane peptidase family (DUF2324)
TD69_RS25415	COG0739	heme binding
TD69_RS25425	COG3377	Domain of unknown function (DUF1805)
TD69_RS25430	COG0737	Belongs to the 5'-nucleotidase family
TD69_RS25440	COG1695	Transcriptional regulator
TD69_RS25455	COG0719	Fe-S assembly protein
TD69_RS25460	COG0822	iron-sulfur transferase activity
TD69_RS25465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TD69_RS25470	COG0719	Fe-S assembly protein
TD69_RS25475	COG0396	ATPase activity
TD69_RS25480	COG1464	Belongs to the NlpA lipoprotein family
TD69_RS25485	COG1464	Belongs to the NlpA lipoprotein family
TD69_RS25490	COG2011	ABC-type metal ion transport system permease component
TD69_RS25495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TD69_RS25510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TD69_RS25515	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
TD69_RS25525	COG1393	Belongs to the ArsC family
TD69_RS25575	COG0039	L-malate dehydrogenase activity
TD69_RS25600	COG1309	transcriptional regulator
TD69_RS25605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TD69_RS25610	COG1960	acyl-CoA dehydrogenase activity
TD69_RS25620	COG0183	Belongs to the thiolase family
TD69_RS25625	COG1024	Enoyl-CoA hydratase
TD69_RS25625	COG1250	3-hydroxyacyl-CoA dehydrogenase
TD69_RS25635	COG1686	Belongs to the peptidase S11 family
TD69_RS25650	COG0011	TIGRFAM Protein of
TD69_RS25655	COG0840	transmembrane signaling receptor activity
TD69_RS25675	COG2814	Major facilitator Superfamily
TD69_RS25680	COG0531	amino acid
TD69_RS25690	COG0706	membrane insertase activity
TD69_RS25700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TD69_RS25735	COG0586	Pfam SNARE associated Golgi protein
TD69_RS25745	COG1376	ErfK ybiS ycfS ynhG family protein
TD69_RS25750	COG0745	RESPONSE REGULATOR receiver
TD69_RS25755	COG5002	protein histidine kinase activity
TD69_RS25780	COG2151	metal-sulfur cluster biosynthetic enzyme
TD69_RS25785	COG3227	Zinc metalloprotease (Elastase)
TD69_RS25790	COG1741	Belongs to the pirin family
TD69_RS25805	COG0475	glutathione-regulated potassium exporter activity
TD69_RS25810	COG0490	domain, Protein
TD69_RS25820	COG1115	amino acid carrier protein
TD69_RS25825	COG0783	Belongs to the Dps family
TD69_RS25840	COG1611	Belongs to the LOG family
TD69_RS25855	COG2311	Membrane
TD69_RS25865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TD69_RS25870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TD69_RS25875	COG1115	amino acid carrier protein
TD69_RS25880	COG1115	amino acid carrier protein
TD69_RS25885	COG2910	NAD(P)H-binding
TD69_RS25900	COG0656	L-ascorbic acid biosynthetic process
TD69_RS25905	COG2814	Major facilitator Superfamily
TD69_RS25910	COG1733	regulation of RNA biosynthetic process
TD69_RS25920	COG1252	NADH dehydrogenase
TD69_RS25925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TD69_RS25930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TD69_RS25940	COG0840	transmembrane signaling receptor activity
TD69_RS25940	COG3290	protein histidine kinase activity
TD69_RS25950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TD69_RS25955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TD69_RS25970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TD69_RS26020	COG0557	exoribonuclease II activity
TD69_RS26025	COG1647	Serine aminopeptidase, S33
TD69_RS26030	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TD69_RS26035	COG1346	cytolysis
TD69_RS26135	COG4695	Portal protein
TD69_RS26160	COG4974	Belongs to the 'phage' integrase family
TD69_RS26170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TD69_RS26175	COG0149	triose-phosphate isomerase activity
TD69_RS26185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TD69_RS26200	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TD69_RS26225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TD69_RS26240	COG2323	membrane
TD69_RS26245	COG0740	serine-type endopeptidase activity
TD69_RS26250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TD69_RS26260	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TD69_RS26270	COG1051	belongs to the nudix hydrolase family
TD69_RS26280	COG0492	ferredoxin-NADP+ reductase activity
TD69_RS26285	COG0457	Tetratricopeptide repeat
TD69_RS26290	COG0110	maltose O-acetyltransferase activity
TD69_RS26310	COG1950	PFAM Membrane protein of
TD69_RS26320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TD69_RS26325	COG0556	nucleotide-excision repair
TD69_RS26345	COG0789	Transcriptional regulator
TD69_RS26370	COG2855	membrane
TD69_RS26375	COG0583	DNA-binding transcription factor activity
TD69_RS26385	COG0655	NAD(P)H dehydrogenase (quinone) activity
TD69_RS26390	COG0488	(ABC) transporter
TD69_RS26400	COG1132	(ABC) transporter
TD69_RS26405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TD69_RS26410	COG3409	Peptidoglycan-binding domain 1 protein
TD69_RS26410	COG0793	Belongs to the peptidase S41A family
TD69_RS26415	COG2177	Part of the ABC transporter FtsEX involved in
TD69_RS26420	COG2884	Cell division ATP-binding protein ftsE
TD69_RS26435	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TD69_RS26440	COG0653	protein targeting
TD69_RS26445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TD69_RS26450	COG1278	Cold shock
TD69_RS26455	COG1040	competence protein
TD69_RS26460	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
TD69_RS26465	COG1388	LysM domain
TD69_RS26465	COG0791	NLP P60 protein
TD69_RS26470	COG1733	regulation of RNA biosynthetic process
TD69_RS26480	COG1307	EDD domain protein, DegV family
TD69_RS26485	COG1739	Uncharacterized protein family UPF0029
TD69_RS26490	COG1316	TRANSCRIPTIONal
TD69_RS26495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TD69_RS26500	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TD69_RS26505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TD69_RS26515	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TD69_RS26515	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TD69_RS26530	COG3394	polysaccharide catabolic process
TD69_RS26535	COG1486	melibiose metabolic process
TD69_RS26540	COG1447	Phosphotransferase system cellobiose-specific component IIA
TD69_RS26545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TD69_RS26555	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TD69_RS26560	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TD69_RS26565	COG1447	Phosphotransferase system cellobiose-specific component IIA
TD69_RS26575	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TD69_RS26580	COG1301	dicarboxylic acid transport
TD69_RS26590	COG0346	lactoylglutathione lyase activity
TD69_RS26595	COG1511	domain protein
TD69_RS26600	COG0583	DNA-binding transcription factor activity
TD69_RS26605	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
TD69_RS26625	COG1271	oxidase subunit
TD69_RS26630	COG1294	oxidase, subunit
TD69_RS26635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TD69_RS26645	COG1620	l-lactate permease
TD69_RS26655	COG2389	metal-binding protein
TD69_RS26665	COG1368	sulfuric ester hydrolase activity
TD69_RS26680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TD69_RS26700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TD69_RS26705	COG3584	3D domain protein
TD69_RS26705	COG1388	LysM domain
TD69_RS26730	COG4715	Zinc finger, swim domain protein
TD69_RS26735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TD69_RS26775	COG0577	efflux transmembrane transporter activity
TD69_RS26780	COG1136	(ABC) transporter
TD69_RS26815	COG5002	protein histidine kinase activity
TD69_RS26820	COG0745	RESPONSE REGULATOR receiver
TD69_RS26825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TD69_RS26845	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TD69_RS26850	COG1134	teichoic acid transport
TD69_RS26855	COG1682	transport, permease protein
TD69_RS26860	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TD69_RS26905	COG1609	Transcriptional regulator
TD69_RS26920	COG0739	heme binding
TD69_RS26935	COG3279	Response regulator of the LytR AlgR family
TD69_RS26940	COG4555	ABC transporter
TD69_RS26945	COG2385	sporulation resulting in formation of a cellular spore
TD69_RS26960	COG4836	Membrane
TD69_RS26965	COG1007	ATP synthesis coupled electron transport
TD69_RS26970	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TD69_RS26975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TD69_RS26985	COG0839	Belongs to the complex I subunit 6 family
TD69_RS27000	COG0649	NAD binding
TD69_RS27005	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TD69_RS27020	COG5001	Diguanylate cyclase
TD69_RS27020	COG3300	MHYT domain
TD69_RS27070	COG0356	it plays a direct role in the translocation of protons across the membrane
TD69_RS27105	COG0698	ribose 5-phosphate isomerase
TD69_RS27115	COG2190	(PTS) system
TD69_RS27120	COG2259	Doxx family
TD69_RS27125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TD69_RS27140	COG0009	L-threonylcarbamoyladenylate synthase
TD69_RS27155	COG2890	protein-(glutamine-N5) methyltransferase activity
TD69_RS27175	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TD69_RS27180	COG1494	fructose-1,6-bisphosphatase
TD69_RS27200	COG4821	SIS domain
TD69_RS27210	COG3343	RNA polymerase activity
TD69_RS27220	COG1960	acyl-CoA dehydrogenase activity
TD69_RS27225	COG1960	acyl-CoA dehydrogenase activity
TD69_RS27230	COG1250	3-hydroxyacyl-CoA dehydrogenase
TD69_RS27235	COG0183	Belongs to the thiolase family
TD69_RS27240	COG2181	nitrate reductase activity
TD69_RS27240	COG0247	lactate metabolic process
TD69_RS27245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TD69_RS27255	COG5001	Diguanylate cyclase
TD69_RS27255	COG3300	MHYT domain
TD69_RS27270	COG2197	response regulator
TD69_RS27275	COG4585	Histidine kinase
TD69_RS27280	COG0842	Transport permease protein
TD69_RS27285	COG1131	(ABC) transporter
TD69_RS27290	COG0024	Methionine aminopeptidase
TD69_RS27310	COG2234	aminopeptidase activity
TD69_RS27330	COG1595	DNA-templated transcription, initiation
TD69_RS27335	COG0018	arginyl-trna synthetase
TD69_RS27340	COG4506	Protein conserved in bacteria
TD69_RS27345	COG1619	proteins homologs of microcin C7 resistance protein MccF
TD69_RS27365	COG0010	Belongs to the arginase family
TD69_RS27375	COG2814	Major facilitator Superfamily
TD69_RS27380	COG0789	Transcriptional regulator
TD69_RS27385	COG0584	glycerophosphoryl diester phosphodiesterase
TD69_RS27390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TD69_RS27400	COG1994	Peptidase M50
TD69_RS27410	COG1078	dGTPase activity
TD69_RS27415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TD69_RS27420	COG1120	ATPase activity
TD69_RS27425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TD69_RS27430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TD69_RS27435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TD69_RS27455	COG0095	Lipoate-protein ligase
TD69_RS27460	COG0280	phosphate acetyltransferase
TD69_RS27475	COG3773	Cell wall hydrolase
TD69_RS27485	COG2363	Small membrane protein
TD69_RS27500	COG2233	PERMEase
TD69_RS27505	COG0561	phosphatase activity
TD69_RS27510	COG2814	Major facilitator Superfamily
TD69_RS27520	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
TD69_RS27525	COG1131	(ABC) transporter
TD69_RS27530	COG2755	lipolytic protein G-D-S-L family
TD69_RS27535	COG1609	Transcriptional regulator
TD69_RS27545	COG0460	homoserine dehydrogenase
TD69_RS27555	COG2873	o-acetylhomoserine
TD69_RS27565	COG1011	Hydrolase
TD69_RS27570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TD69_RS27580	COG2197	response regulator
TD69_RS27590	COG0351	phosphomethylpyrimidine kinase
TD69_RS27595	COG3706	GGDEF domain
TD69_RS27600	COG2879	small protein
TD69_RS27605	COG1966	Carbon starvation protein
TD69_RS27610	COG3279	Response regulator of the LytR AlgR family
TD69_RS27615	COG0477	Major facilitator Superfamily
TD69_RS27640	COG0840	transmembrane signaling receptor activity
TD69_RS27650	COG1607	acyl-coa hydrolase
TD69_RS27665	COG0488	(ABC) transporter
TD69_RS27690	COG0463	Glycosyl transferase, family 2
TD69_RS27695	COG1309	transcriptional regulator
TD69_RS27700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TD69_RS27705	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TD69_RS27705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TD69_RS27710	COG0628	permease
TD69_RS27725	COG3279	Response regulator of the LytR AlgR family
TD69_RS27730	COG3275	phosphorelay sensor kinase activity
TD69_RS27735	COG2814	Major facilitator Superfamily
TD69_RS27740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TD69_RS27745	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
TD69_RS27750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TD69_RS27770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TD69_RS27775	COG1272	protein, Hemolysin III
TD69_RS27795	COG0516	GMP reductase activity
TD69_RS27800	COG1164	Oligoendopeptidase f
TD69_RS27820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TD69_RS27825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TD69_RS27830	COG4853	Protein conserved in bacteria
TD69_RS27835	COG4863	YycH protein
TD69_RS27840	COG5002	protein histidine kinase activity
TD69_RS27845	COG0745	RESPONSE REGULATOR receiver
TD69_RS27875	COG0305	Participates in initiation and elongation during chromosome replication
TD69_RS27885	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TD69_RS27890	COG4241	membrane
TD69_RS27900	COG0629	single-stranded DNA binding
TD69_RS27910	COG0012	GTP binding
TD69_RS27915	COG4481	Protein conserved in bacteria
TD69_RS27920	COG0668	transmembrane transport
TD69_RS27930	COG1475	DNA binding
TD69_RS27935	COG1192	Involved in chromosome partitioning
TD69_RS27960	COG1847	R3H domain protein
TD69_RS27965	COG0706	membrane insertase activity
TD69_RS27975	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TD69_RS28140	COG1774	PSP1 C-terminal conserved region
TD69_RS28250	COG3956	TIGRFAM MazG family protein
TD69_RS28330	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TD69_RS28435	COG1045	serine acetyltransferase
TD69_RS28670	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TD69_RS28740	COG2610	gluconate transmembrane transporter activity
TD69_RS28745	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TD69_RS28805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TD69_RS29150	COG2208	phosphoserine phosphatase activity
TD69_RS29165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TD69_RS29170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TD69_RS29310	COG2376	Dihydroxyacetone kinase