locus-tag class description BF25_RS00005 ENOG4108J59 Extracellular solute-binding protein, family 5 BF25_RS00040 ENOG4105N14 lysine exporter protein LysE YggA BF25_RS00070 ENOG4105C3F Signal peptidase i BF25_RS00145 ENOG4105EWC Purine nucleoside phosphorylase BF25_RS00190 ENOG4107QJE Chromosome Partitioning Protein BF25_RS00335 ENOG4105K4H Nlp p60 protein BF25_RS00465 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF25_RS00505 ENOG4105DHF Membrane BF25_RS00730 ENOG4105CNU cell division protein FtsK BF25_RS00845 ENOG4105EKQ RNA-directed DNA polymerase BF25_RS00925 ENOG4105EKQ RNA-directed DNA polymerase BF25_RS01045 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) BF25_RS01055 ENOG4108MEK Metal-binding protein YodA BF25_RS01085 ENOG4108IBT Inherit from COG: transposase BF25_RS01115 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF25_RS01290 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF25_RS01295 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF25_RS01300 ENOG4108NV9 Glycosyl Transferase BF25_RS01320 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF25_RS01345 ENOG4108VDD TRNA binding domain protein BF25_RS01390 ENOG4105C88 aminopeptidase BF25_RS01415 ENOG4105ETE Transcriptional regulator (LacI family BF25_RS01445 ENOG4105EP9 oxidoreductase BF25_RS01450 ENOG4107SNB ankyrin repeat protein YahD BF25_RS01460 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF25_RS01470 ENOG4105DGU Histone deacetylase BF25_RS01475 ENOG4105W87 Cbs domain BF25_RS01480 ENOG4105F1V Acetoin utilization protein BF25_RS01495 ENOG4105EMN RNA polymerase sigma factor BF25_RS01525 ENOG4105C28 cystathionine BF25_RS01545 ENOG4106KR7 LysR family Transcriptional regulator BF25_RS01570 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF25_RS01580 ENOG4105EFZ amidohydrolase BF25_RS01595 ENOG4105KBJ sporulation protein ytfj BF25_RS01600 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BF25_RS01610 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BF25_RS01630 ENOG4108JYZ YitT family BF25_RS01670 ENOG4107YZX Universal stress protein BF25_RS01690 ENOG4105VZ8 Transcriptional regulator BF25_RS01700 ENOG41082W1 Cupin 2, conserved barrel domain protein BF25_RS01705 ENOG4105Z7P Acetyltransferase (GNAT) family BF25_RS01740 ENOG4105DC7 peptidase M24 BF25_RS01775 ENOG4105SFS phosphoesterase RecJ domain protein BF25_RS01785 ENOG4105VV2 BF25_RS01790 ENOG4105C0B DNA polymerase III (alpha subunit) BF25_RS01795 ENOG4105C6K Malic enzyme BF25_RS01800 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF25_RS01825 ENOG4105FS0 cytoplasmic membrane protein BF25_RS01830 ENOG4108REF Sporulation integral membrane protein ytvi BF25_RS01845 ENOG4105BZN citrate synthase BF25_RS01850 ENOG4108HMX isocitrate dehydrogenase (NADP) BF25_RS01870 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF25_RS01875 ENOG4105BZU Histidine kinase BF25_RS01880 ENOG4105C2M dna polymerase I BF25_RS01895 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BF25_RS01900 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BF25_RS01925 ENOG4108TDW sporulation protein YtxC BF25_RS01930 ENOG4105C22 threonyL-tRNA synthetase BF25_RS01955 ENOG4105CN9 Peptidase m42 family protein BF25_RS01960 ENOG4108JGH Tetr family transcriptional regulator BF25_RS01965 ENOG4105CW7 secretion protein, HlyD family BF25_RS01970 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF25_RS02005 ENOG4108RWN rrna methyltransferase BF25_RS02055 ENOG4105DCG PHP domain protein BF25_RS02070 ENOG4105FE9 pseudouridine synthase BF25_RS02080 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BF25_RS02090 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BF25_RS02105 ENOG4105E0A ABC, transporter BF25_RS02110 ENOG4105KFN sortase, SrtB family BF25_RS02125 ENOG4105DR4 Methyltransferase BF25_RS02140 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF25_RS02185 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF25_RS02190 ENOG4105J76 Periplasmic binding protein BF25_RS02200 ENOG4105CEY Amp-dependent synthetase and ligase BF25_RS02205 ENOG4107Z3H Transcriptional regulator, TetR family BF25_RS02210 ENOG41060WC Enoyl-CoA hydratase BF25_RS02215 ENOG4105BZJ Electron transfer flavoprotein BF25_RS02220 ENOG4105C10 Electron transfer flavoprotein BF25_RS02225 ENOG4105K63 Thioredoxin BF25_RS02240 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BF25_RS02250 ENOG4105E33 succinate dehydrogenase BF25_RS02260 ENOG4108VXD carboxy-peptidase BF25_RS02265 ENOG4105E14 MotA TolQ exbB proton channel BF25_RS02275 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BF25_RS02280 ENOG4108IUX (ABC) transporter BF25_RS02285 ENOG4105RHA ABC transporter, permease BF25_RS02290 ENOG4108Z40 Transcriptional regulator BF25_RS02295 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BF25_RS02305 ENOG4108JCI Transcriptional regulator BF25_RS02310 ENOG41067S9 phage shock protein C, PspC BF25_RS02325 ENOG4105DY9 regulatoR BF25_RS02330 ENOG4108HRK Histidine kinase BF25_RS02335 ENOG4108JQ7 (ABC) transporter BF25_RS02350 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF25_RS02355 ENOG4105DEF Extracellular solute-binding protein, family 5 BF25_RS02360 ENOG4105DZC cytosine deaminase BF25_RS02365 ENOG4105DZC cytosine deaminase BF25_RS02380 ENOG4105PFC Transcriptional regulator BF25_RS02395 ENOG4105KBX Transcriptional regulator, TetR family BF25_RS02405 ENOG4108PCX Major Facilitator BF25_RS02415 ENOG4108XJQ germination protein BF25_RS02430 ENOG4105M59 Phosphodiesterase, mj0936 family BF25_RS02450 ENOG4108QCI YvbH-like oligomerisation region BF25_RS02480 ENOG4108IUQ atp-dependent protease BF25_RS02500 ENOG4105K56 Transcriptional regulator BF25_RS02525 ENOG4105D52 delta-aminolevulinic acid dehydratase BF25_RS02535 ENOG41068KH stage VI sporulation protein D BF25_RS02545 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BF25_RS02550 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BF25_RS02570 ENOG4105DFF Rod shape-determining protein mreb BF25_RS02590 ENOG4107QMS site-determining protein BF25_RS02605 ENOG4105C03 ribonuclease BF25_RS02615 ENOG4105X36 (ribosomal) protein BF25_RS02630 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BF25_RS02665 ENOG4105CQC Prephenate dehydratase BF25_RS02670 ENOG4108RPX mosc domain containing protein BF25_RS02685 ENOG4108IYU L-aspartate oxidase BF25_RS02690 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BF25_RS02715 ENOG41082BM Transcriptional regulator, arsr family BF25_RS02720 ENOG4108IPJ Membrane BF25_RS02725 ENOG4108IPJ Membrane BF25_RS02735 ENOG4108HUF Transporter BF25_RS02750 ENOG41061AI Protein of unknown function (DUF2905) BF25_RS02765 ENOG4105VIE preprotein translocase, subunit YajC BF25_RS02775 ENOG4108QG2 Membrane BF25_RS02780 ENOG4105CKP Polysaccharide Biosynthesis Protein BF25_RS02790 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BF25_RS02795 ENOG41076HS cation diffusion facilitator family transporter BF25_RS02800 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BF25_RS02810 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF25_RS02835 ENOG4105CUZ uba thif-type nad fad binding protein BF25_RS02840 ENOG4108VCI transcription factor, rsfa family BF25_RS02845 ENOG4105D1H recombination factor protein RarA BF25_RS02855 ENOG4105C3J Cysteine desulfurase BF25_RS02860 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BF25_RS02870 ENOG4105C7H Helicase, RecD TraA family BF25_RS02875 ENOG41060CR BF25_RS02890 ENOG4105C02 permease BF25_RS02900 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF25_RS02920 ENOG4105HHA aminodeoxychorismate lyase BF25_RS02930 ENOG4105XYU peptidase (U32 family) BF25_RS02935 ENOG4105CFP Peptidase U32 BF25_RS02950 ENOG4107XRG penicillin-binding protein BF25_RS02980 ENOG4105C28 cystathionine BF25_RS02985 ENOG4105C0A alcohol dehydrogenase BF25_RS02995 ENOG4108V5C ABC transporter BF25_RS03000 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF25_RS03055 ENOG4105MIR Phenylalanine 4-monooxygenase BF25_RS03060 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF25_RS03095 ENOG4108MUZ hydrolase BF25_RS03105 ENOG4105G6Z alkaline phosphatase BF25_RS03120 ENOG4108TVJ Nitroreductase BF25_RS03140 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF25_RS03155 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF25_RS03160 ENOG4105CQW ribosome biogenesis GTPase YqeH BF25_RS03170 ENOG410812S Rna-binding protein BF25_RS03180 ENOG4108WF2 Metal Dependent Phosphohydrolase BF25_RS03190 ENOG4105DXX methyltransferase BF25_RS03200 ENOG4105KQC Competence protein BF25_RS03205 ENOG4108UK2 deaminase BF25_RS03210 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF25_RS03220 ENOG4105TQK DNA polymerase iii, delta' subunit BF25_RS03245 ENOG4105KVH Transcriptional regulator BF25_RS03250 ENOG4105CSA Coproporphyrinogen iii oxidase BF25_RS03280 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BF25_RS03285 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF25_RS03295 ENOG4105KTH gatB Yqey BF25_RS03300 ENOG41068P3 sporulation protein YqfC BF25_RS03315 ENOG4105C9A Phoh family BF25_RS03320 ENOG4105CTJ Metal Dependent Phosphohydrolase BF25_RS03330 ENOG4107YR5 Diacylglycerol kinase BF25_RS03335 ENOG4105KG3 cytidine deaminase BF25_RS03340 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BF25_RS03375 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BF25_RS03380 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF25_RS03395 ENOG4105EGD dinuclear metal center protein, YbgI family BF25_RS03420 ENOG41069ZM Protein of unknown function (DUF2624) BF25_RS03425 ENOG4108JYZ YitT family BF25_RS03430 ENOG4105FDK ABC transporter BF25_RS03440 ENOG4105N80 Ferric uptake regulator, Fur family BF25_RS03465 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF25_RS03475 ENOG4107RF6 penicillin-binding protein BF25_RS03480 ENOG4105PWN phosphate abc transporter BF25_RS03485 ENOG4105C8U phosphate abc transporter BF25_RS03490 ENOG4105E2Z phosphate ABC transporter (Permease BF25_RS03500 ENOG4108UTW Plays a role in the regulation of phosphate uptake BF25_RS03515 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BF25_RS03525 ENOG4105DKQ ROK family BF25_RS03535 ENOG4105C5X domain protein BF25_RS03560 ENOG4105C28 cystathionine BF25_RS03565 ENOG4105C28 cystathionine BF25_RS03580 ENOG4105C3R Methionine synthase BF25_RS03585 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF25_RS03705 ENOG4105C0D helicase BF25_RS03735 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF25_RS03740 ENOG4105CJ1 ABC, transporter BF25_RS03780 ENOG41080TC multidrug resistance protein BF25_RS03800 ENOG4105WZW rhodanese family BF25_RS03805 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BF25_RS03825 ENOG4107YBY Hydrolase BF25_RS03835 ENOG4105CBJ Metal-dependent enzyme BF25_RS03850 ENOG4105DC7 peptidase M24 BF25_RS03875 ENOG4105CD2 stage iii sporulation protein aa BF25_RS03880 ENOG4105KR5 Stage iii sporulation protein BF25_RS03885 ENOG4108CQH stage III sporulation protein AC BF25_RS03890 ENOG4105KQ4 Stage iii sporulation protein ad BF25_RS03900 ENOG410644B Stage III sporulation protein af BF25_RS03925 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF25_RS03930 ENOG4108ZSR alkaline shock protein BF25_RS03955 ENOG4105CTB Polyprenyl synthetase BF25_RS03965 ENOG4105DX0 Hemolysin A BF25_RS03975 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BF25_RS03980 ENOG4105S1Z Stage IV sporulation protein B BF25_RS03985 ENOG4107QQR Sporulation BF25_RS04000 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF25_RS04010 ENOG4108JUB Transcriptional regulator BF25_RS04025 ENOG4107RDP Dehydrogenase BF25_RS04045 ENOG4105CPP Dehydrogenase, E1 component BF25_RS04050 ENOG4105C7S Dehydrogenase BF25_RS04070 ENOG4105G7B Protein of unknown function (DUF2992) BF25_RS04085 ENOG4108HW3 (ABC) transporter BF25_RS04090 ENOG4105E5Q amino acid AbC transporter BF25_RS04095 ENOG4105CDA abc transporter atp-binding protein BF25_RS04100 ENOG4108QEG Membrane BF25_RS04105 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BF25_RS04120 ENOG4105D9U N-acetyltransferase BF25_RS04125 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BF25_RS04135 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF25_RS04160 ENOG4105EJQ L-serine dehydratase BF25_RS04165 ENOG4105II7 pyrroline-5-carboxylate reductase BF25_RS04180 ENOG4108IXY short-chain dehydrogenase reductase BF25_RS04195 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BF25_RS04235 ENOG4105CGH 5'-nucleotidase BF25_RS04240 ENOG4105DFD Na H antiporter BF25_RS04250 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF25_RS04265 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF25_RS04270 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF25_RS04295 ENOG4108R6K riboflavin synthase, subunit alpha BF25_RS04300 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BF25_RS04320 ENOG4108YM7 Gcn5-related n-acetyltransferase BF25_RS04325 ENOG4105ETE Transcriptional regulator (LacI family BF25_RS04335 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF25_RS04355 ENOG4105RHY Pfam:UPF0157 BF25_RS04365 ENOG4105CPC Aldo Keto reductase BF25_RS04385 ENOG4105MZ9 stage II sporulation protein m BF25_RS04390 ENOG4105I3K Ferric uptake regulator, Fur family BF25_RS04400 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF25_RS04425 ENOG4105D7N magnesium and cobalt transport protein CorA BF25_RS04460 ENOG4105DVE abc transporter atp-binding protein BF25_RS04465 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF25_RS04470 ENOG4105DZ1 carboxypeptidase BF25_RS04475 ENOG41082AN stage II sporulation protein BF25_RS04485 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF25_RS04490 ENOG4105C8J )-transporter BF25_RS04510 ENOG41090VF Stage v sporulation protein ac BF25_RS04515 ENOG4105CZ3 stage V sporulation protein ad BF25_RS04525 ENOG4105G6R Stage v sporulation protein ae BF25_RS04535 ENOG4105J7I hydrolase BF25_RS04540 ENOG4105PTM secreted protein BF25_RS04545 ENOG4107ZE5 PPIases accelerate the folding of proteins BF25_RS04590 ENOG4105CE4 GlcNAc 6-P deacetylase BF25_RS04610 ENOG4105CID antiterminator BF25_RS04625 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BF25_RS04645 ENOG4106TD9 Diguanylate cyclase BF25_RS04665 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BF25_RS04690 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BF25_RS04710 ENOG4105DTD Dehydrogenase BF25_RS04715 ENOG4105K7K Transcriptional regulator BF25_RS04755 ENOG4105CHU acetyl-coa acetyltransferase BF25_RS04800 ENOG4105CG3 alpha amylase, catalytic region BF25_RS04810 ENOG4107FKK extracellular solute-binding protein family 1 BF25_RS04820 ENOG4105EG2 ABC transporter, permease BF25_RS04825 ENOG4105FKQ transcriptional regulator BF25_RS04830 ENOG4105CHM Aminotransferase BF25_RS04840 ENOG4108HGU Histidine kinase BF25_RS04905 ENOG4105UIN BF25_RS04915 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BF25_RS04930 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BF25_RS04935 ENOG4105EPM Diguanylate phosphodiesterase BF25_RS04950 ENOG4107IN1 Protein of unknown function (DUF1797) BF25_RS04960 ENOG4108XRC Protein of unknown function (DUF458) BF25_RS04995 ENOG4107ZYR domain protein BF25_RS05000 ENOG4105CN5 Metallo-Beta-Lactamase BF25_RS05010 ENOG4108X4Q Hydrolase BF25_RS05015 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF25_RS05030 ENOG4105CPP Dehydrogenase, E1 component BF25_RS05035 ENOG4105C7S Dehydrogenase BF25_RS05080 ENOG4105CXN decarboxylase BF25_RS05100 ENOG4105ECY inositol monophosphatase BF25_RS05110 ENOG4105CI3 gtp-binding protein typa BF25_RS05115 ENOG4105QA2 BF25_RS05135 ENOG4108IAB Phoh family BF25_RS05150 ENOG4105CNI cell division protein FtsW BF25_RS05155 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BF25_RS05205 ENOG4106UY4 Inherit from COG: Scp-like extracellular BF25_RS05220 ENOG4107TB6 phosphoglycerate mutase BF25_RS05240 ENOG4106H78 methyltransferase BF25_RS05250 ENOG4105H20 Sporulation integral membrane protein YlbJ BF25_RS05255 ENOG4105D78 K07001 NTE family protein BF25_RS05260 ENOG41063PX domain protein BF25_RS05270 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BF25_RS05295 ENOG4108IMY Transcriptional regulator BF25_RS05350 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF25_RS05455 ENOG4105CAR Terminase, large subunit BF25_RS05550 ENOG4105XSJ toxin secretion phage lysis holin BF25_RS05600 ENOG4105KNH Nucleic acid-binding protein BF25_RS05635 ENOG41068DC Essential cell division protein (By similarity) BF25_RS05640 ENOG4105CJN penicillin-binding protein BF25_RS05645 ENOG4105CJN penicillin-binding protein BF25_RS05650 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF25_RS05665 ENOG4105CNI cell division protein FtsW BF25_RS05675 ENOG4105D4A Cell wall formation (By similarity) BF25_RS05680 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BF25_RS05685 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BF25_RS05690 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BF25_RS05700 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF25_RS05710 ENOG4105WR5 sporulation protein, YlmC YmxH family BF25_RS05715 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BF25_RS05720 ENOG4105DFA alanine racemase domain protein BF25_RS05730 ENOG41067XK integral membrane protein BF25_RS05735 ENOG4105DBK s4 domain protein BF25_RS05760 ENOG4105C34 Pseudouridine synthase BF25_RS05840 ENOG4105DC7 peptidase M24 BF25_RS05855 ENOG4105DSJ YicC domain protein BF25_RS05875 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BF25_RS05880 ENOG4105C25 Primosomal protein n' BF25_RS05885 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF25_RS05895 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BF25_RS05905 ENOG4108ZF3 Phosphatase BF25_RS05910 ENOG4105D9P serine threonine protein kinase BF25_RS05915 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BF25_RS05920 ENOG4105DJV ribulose-phosphate 3-epimerase BF25_RS05925 ENOG4105FJ0 thiamine BF25_RS05940 ENOG4108ZAA Alkaline-shock protein BF25_RS05945 ENOG4105DP4 dak2 domain fusion protein ylov BF25_RS05950 ENOG4105CB5 ATP-dependent DNA helicase recG BF25_RS05965 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BF25_RS05970 ENOG4105CHR reductase BF25_RS05985 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BF25_RS05990 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BF25_RS06010 ENOG4105VB6 UPF0109 protein BF25_RS06035 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BF25_RS06050 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BF25_RS06060 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF25_RS06070 ENOG4108HE4 integrase family BF25_RS06110 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BF25_RS06115 ENOG4105KNE Phosphatidate cytidylyltransferase BF25_RS06125 ENOG4105DZP Membrane-associated zinc metalloprotease BF25_RS06135 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF25_RS06145 ENOG4105CHV Transcription elongation factor NusA BF25_RS06150 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BF25_RS06155 ENOG4105VHM ribosomal protein BF25_RS06165 ENOG4105W7A Protein of unknown function (DUF503) BF25_RS06175 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BF25_RS06180 ENOG4105DTN riboflavin biosynthesis protein ribF BF25_RS06200 ENOG4105C1V Peptidase, M16 BF25_RS06210 ENOG4105E35 Dipicolinate synthase subunit A BF25_RS06215 ENOG4108S0H Dipicolinic acid synthetase, b subunit BF25_RS06220 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF25_RS06230 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF25_RS06245 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BF25_RS06255 ENOG4107QZI cell division protein FtsK BF25_RS06260 ENOG4105FDP GntR family transcriptional regulator BF25_RS06265 ENOG4105DIH basic membrane BF25_RS06270 ENOG4108JQ9 ABC transporter BF25_RS06300 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BF25_RS06305 ENOG4105XZV Protein of unknown function (DUF3243) BF25_RS06320 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BF25_RS06345 ENOG4105D48 metallophosphoesterase BF25_RS06350 ENOG4105MCT stage V sporulation protein S BF25_RS06355 ENOG4108IGT Dipeptidase BF25_RS06360 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BF25_RS06365 ENOG4105DQU oxidoreductase, subunit beta BF25_RS06370 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF25_RS06395 ENOG4105DA5 (ABC) transporter BF25_RS06420 ENOG4107QHE Choloylglycine hydrolase BF25_RS06430 ENOG410890F Dynamin family BF25_RS06435 ENOG4105E0M Sulfatase BF25_RS06440 ENOG4107R6R udp-galactopyranose mutase BF25_RS06445 ENOG4105F0V Cell wall hydrolase BF25_RS06465 ENOG4107YEI lmbE family BF25_RS06470 ENOG4107TTQ Alpha beta hydrolase fold BF25_RS06485 ENOG41067MG lrgb family BF25_RS06505 ENOG4105BZU Histidine kinase BF25_RS06510 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BF25_RS06540 ENOG4105D03 DNA-3-methyladenine glycosylase II BF25_RS06545 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF25_RS06555 ENOG4105CGK Exodeoxyribonuclease III BF25_RS06580 ENOG4105E0A ABC, transporter BF25_RS06585 ENOG4105NIV Esterase BF25_RS06595 ENOG4105VPX protein, conserved in bacteria BF25_RS06600 ENOG410681U heavy metal transport detoxification protein BF25_RS06605 ENOG4105C59 p-type ATPase BF25_RS06610 ENOG4105K70 DNA-binding protein BF25_RS06615 ENOG4105TMB Formate nitrite transporter BF25_RS06630 ENOG4105C85 amino acid BF25_RS06645 ENOG4108SJC Membrane BF25_RS06655 ENOG4105E98 transcriptional regulator DeoR family BF25_RS06660 ENOG4105DE4 1-phosphofructokinase BF25_RS06665 ENOG4105DM4 PTS System BF25_RS06670 ENOG41069ER domain protein BF25_RS06700 ENOG4106F1P AAA ATPase, central domain protein BF25_RS06705 ENOG4105EN6 Membrane BF25_RS06715 ENOG4105CXI aluminum resistance protein BF25_RS06720 ENOG4105KV4 Transcriptional regulator BF25_RS06725 ENOG4105C5F glutamine synthetase BF25_RS06830 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BF25_RS07035 ENOG4105XSJ toxin secretion phage lysis holin BF25_RS07040 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BF25_RS07075 ENOG4105K7K Transcriptional regulator BF25_RS07095 ENOG4108SVB resolvase BF25_RS07120 ENOG4105D5T phosphonate abc transporter BF25_RS07140 ENOG4105D7V transposase BF25_RS07160 ENOG4105BZ1 (ABC) transporter BF25_RS07165 ENOG4105BZ1 (ABC) transporter BF25_RS07180 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF25_RS07205 ENOG41067MG lrgb family BF25_RS07210 ENOG4105VAW lrga family BF25_RS07215 ENOG4107RSM transcriptional regulator BF25_RS07225 ENOG4107QIV Cytochrome c biogenesis protein BF25_RS07285 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BF25_RS07310 ENOG4108903 Formimidoylglutamase BF25_RS07315 ENOG4108VJ1 Transcriptional regulator (CarD family BF25_RS07320 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BF25_RS07325 ENOG4105CBC glutamate synthase BF25_RS07330 ENOG4105CK7 Sodium proline symporter BF25_RS07335 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BF25_RS07340 ENOG4105FBA Phospholipase Carboxylesterase BF25_RS07345 ENOG4105BZU Histidine kinase BF25_RS07355 ENOG4107AYK membrAne BF25_RS07400 ENOG4105CEY Amp-dependent synthetase and ligase BF25_RS07405 ENOG4107ZYJ bioY protein BF25_RS07410 ENOG4107F3J Amp-dependent synthetase and ligase BF25_RS07430 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF25_RS07470 ENOG4108I0Z Aconitate hydratase BF25_RS07475 ENOG4108JJA ABC, transporter BF25_RS07485 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF25_RS07490 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF25_RS07520 ENOG4105W8X HesB YadR YfhF-family protein BF25_RS07525 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF25_RS07530 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BF25_RS07540 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_RS07545 ENOG4105C0H protease BF25_RS07550 ENOG4105K4P CoA-binding domain protein BF25_RS07560 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF25_RS07570 ENOG4105D9R oxidoreductase BF25_RS07580 ENOG4105CIG ABC transporter BF25_RS07605 ENOG4105EMN RNA polymerase sigma factor BF25_RS07615 ENOG4108KGH TRANSCRIPTIONal BF25_RS07680 ENOG4105E1K spore germination protein BF25_RS07690 ENOG4108JB9 formate dehydrogenase BF25_RS07700 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BF25_RS07705 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF25_RS07715 ENOG4105TMB Formate nitrite transporter BF25_RS07720 ENOG4105D06 uba thif-type nad fad binding protein BF25_RS07725 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF25_RS07730 ENOG4108ZAF Molybdopterin BF25_RS07740 ENOG4105D1F ATP-binding protein BF25_RS07755 ENOG410696E Membrane BF25_RS07760 ENOG4105FR1 rard protein BF25_RS07770 ENOG4105EWU Squalene--hopene cyclase BF25_RS07780 ENOG4105CHR reductase BF25_RS07785 ENOG4105C26 Dehydrogenase BF25_RS07790 ENOG4105RG0 Membrane BF25_RS07795 ENOG4108IA2 Sodium pantothenate symporter BF25_RS07810 ENOG4106IQC argininosuccinate lyase BF25_RS07820 ENOG410904N short-chain dehydrogenase reductase BF25_RS07840 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BF25_RS07860 ENOG4105VEQ Cold shock protein BF25_RS07880 ENOG4108R1P BF25_RS07890 ENOG41073R8 VanW family BF25_RS07895 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF25_RS07905 ENOG4105KT7 mgtC SapB transporter BF25_RS07915 ENOG4105E39 Enoyl-CoA hydratase BF25_RS07920 ENOG4105K64 Glycosyl transferase, family 2 BF25_RS07930 ENOG4108UT6 Transferase hexapeptide repeat containing protein BF25_RS07950 ENOG4105CQB FAD linked oxidase domain protein BF25_RS07955 ENOG4105C09 Bile acid BF25_RS07965 ENOG4105RHY Pfam:UPF0157 BF25_RS07990 ENOG4105CIS alcohol dehydrogenase BF25_RS07995 ENOG41082BM Transcriptional regulator, arsr family BF25_RS08020 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF25_RS08050 ENOG4108A04 Beta-lactamase BF25_RS08055 ENOG4105DPN Oligoendopeptidase f BF25_RS08065 ENOG4105E5K Alpha-amylase BF25_RS08075 ENOG4105C98 muts2 protein BF25_RS08095 ENOG4107V2S Transcriptional regulator BF25_RS08105 ENOG4107CUJ Protein of unknown function (DUF2690) BF25_RS08125 ENOG4107ZY0 Phenazine biosynthesis-like protein BF25_RS08130 ENOG4105NX3 Membrane BF25_RS08135 ENOG4105DQ5 transport system permease protein BF25_RS08140 ENOG4105EHG Permease protein BF25_RS08150 ENOG4108MES Periplasmic binding protein BF25_RS08170 ENOG4107R3E Citrate transporter BF25_RS08180 ENOG4108TN2 lmbE family BF25_RS08255 ENOG4105H3G oxidoreductase BF25_RS08290 ENOG4107YXZ hydrolase, family 25 BF25_RS08305 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BF25_RS08330 ENOG4105KAF membrAne BF25_RS08400 ENOG4105KVH Transcriptional regulator BF25_RS08420 ENOG4105CHR reductase BF25_RS08430 ENOG4105JAB phenazine biosynthesis protein, phzf family BF25_RS08465 ENOG4105KVH Transcriptional regulator BF25_RS08470 ENOG4105KVH Transcriptional regulator BF25_RS08475 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BF25_RS08485 ENOG4108TZY GntR Family Transcriptional Regulator BF25_RS08490 ENOG4105KVH Transcriptional regulator BF25_RS08525 ENOG4105C44 Serine transporter BF25_RS08530 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BF25_RS08545 ENOG4105F27 Major Facilitator BF25_RS08550 ENOG4105CV8 reductase BF25_RS08570 ENOG4105D4Y metalloprotease BF25_RS08575 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BF25_RS08595 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BF25_RS08600 ENOG4105CIS alcohol dehydrogenase BF25_RS08605 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF25_RS08610 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF25_RS08625 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF25_RS08630 ENOG4105C6Z Gluconate BF25_RS08635 ENOG4105CMG Carbohydrate kinase BF25_RS08640 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BF25_RS08645 ENOG4105XDF Protein of unknown function (DUF1272) BF25_RS08650 ENOG4105DDN Pentapeptide repeat-containing protein BF25_RS08665 ENOG4105C37 (CBS) domain BF25_RS08695 ENOG4105EV4 Multidrug resistance protein mdtH BF25_RS08705 ENOG4105DMQ Methyltransferase BF25_RS08730 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF25_RS08740 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF25_RS08755 ENOG4108UW5 maltose o-acetyltransferase BF25_RS08760 ENOG4106UW1 Major Facilitator superfamily BF25_RS08765 ENOG4105DKQ ROK family BF25_RS08770 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BF25_RS08830 ENOG4105CJ1 ABC, transporter BF25_RS08840 ENOG4108PSK reductase BF25_RS08860 ENOG4108RCM Nitroreductase BF25_RS08865 ENOG4105KVH Transcriptional regulator BF25_RS08880 ENOG4105CUT histidyl-tRNA synthetase BF25_RS08885 ENOG4108Z66 YbaK ebsC protein BF25_RS08895 ENOG41067QW Transcriptional regulator BF25_RS08910 ENOG4108K8S endonuclease I BF25_RS08935 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF25_RS08940 ENOG4108JJB ABC transporter BF25_RS08970 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF25_RS08980 ENOG4105CRW Short chain fatty acid transporter BF25_RS08995 ENOG4105KBX Transcriptional regulator, TetR family BF25_RS09000 ENOG4105KPY Small multidrug resistance protein BF25_RS09005 ENOG4105RXJ BF25_RS09015 ENOG41069JR BF25_RS09020 ENOG4105DA5 (ABC) transporter BF25_RS09040 ENOG4105CZM Major Facilitator BF25_RS09045 ENOG4107MII Sugar-specific transcriptional regulator TrmB BF25_RS09055 ENOG4108ISG Major Facilitator BF25_RS09110 ENOG410874W AraC family transcriptional regulator BF25_RS09120 ENOG41082W1 Cupin 2, conserved barrel domain protein BF25_RS09135 ENOG4108AEY RNA polymerase sigma factor BF25_RS09155 ENOG4108JQ1 Dehydrogenase BF25_RS09170 ENOG4105DVH amino acid BF25_RS09180 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BF25_RS09195 ENOG4108JPW Aminotransferase BF25_RS09210 ENOG4105EJQ L-serine dehydratase BF25_RS09215 ENOG4105C44 Serine transporter BF25_RS09230 ENOG4108JGH Tetr family transcriptional regulator BF25_RS09235 ENOG4105EQ0 Major Facilitator superfamily BF25_RS09250 ENOG4107QJQ Mate efflux family protein BF25_RS09280 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF25_RS09315 ENOG4105TRI Hydrolase BF25_RS09350 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF25_RS09360 ENOG4106P55 Transcriptional regulator BF25_RS09370 ENOG4107QR9 Iron-sulfur cluster binding protein BF25_RS09375 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BF25_RS09380 ENOG4105DJB Major Facilitator Superfamily BF25_RS09385 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF25_RS09400 ENOG4108U05 Transcriptional regulator BF25_RS09415 ENOG4105BZU Histidine kinase BF25_RS09435 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BF25_RS09440 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF25_RS09455 ENOG4105JQZ Methyltransferase BF25_RS09460 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF25_RS09470 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BF25_RS09475 ENOG4108NNI Beta-lactamase domain-containing protein BF25_RS09490 ENOG4105VZ8 Transcriptional regulator BF25_RS09515 ENOG4105K6H D-cysteine desulfhydrase BF25_RS09545 ENOG41062D9 Histidine kinase BF25_RS09550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_RS09565 ENOG4105IIP Membrane BF25_RS09575 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF25_RS09585 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BF25_RS09660 ENOG4108YXU transcriptional regulator AsnC family BF25_RS09665 ENOG4105CHR reductase BF25_RS09675 ENOG4105F7F Chaperone BF25_RS09690 ENOG41085FC arsR family transcriptional regulator BF25_RS09695 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BF25_RS09700 ENOG4105D6J arsenicaL-resistance protein BF25_RS09730 ENOG4105DIK (ABC) transporter BF25_RS09735 ENOG4105CC5 ABC transporter BF25_RS09740 ENOG4105DSE periplasmic solute binding protein BF25_RS09745 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BF25_RS09750 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF25_RS09760 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BF25_RS09765 ENOG4108TWJ NADH dehydrogenase subunit 5 BF25_RS09780 ENOG4105CVP deoxyribo-dipyrimidine photolyase BF25_RS09785 ENOG4108606 TspO/MBR family BF25_RS09850 ENOG4105CHJ isochorismatase hydrolase BF25_RS09860 ENOG4105CH6 catalase BF25_RS09865 ENOG4105CGH 5'-nucleotidase BF25_RS09895 ENOG4105CSV Glutaminase BF25_RS09935 ENOG4105C6K Malic enzyme BF25_RS09945 ENOG4105II7 pyrroline-5-carboxylate reductase BF25_RS09955 ENOG4105CUB amino acid BF25_RS09960 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BF25_RS09970 ENOG4108IMY Transcriptional regulator BF25_RS09975 ENOG4105HDK L-asparaginase BF25_RS09980 ENOG4108IJ0 Aspartate ammonia-lyase BF25_RS09995 ENOG4105E2A Dehydrogenase BF25_RS10060 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BF25_RS10090 ENOG4105DWD nucleoside recognition domain protein BF25_RS10110 ENOG4105FDT acyl-CoA dehydrogenase BF25_RS10120 ENOG4108ZHR arsR family transcriptional regulator BF25_RS10125 ENOG4108ZRV stage ii sporulation protein p BF25_RS10130 ENOG4106N3A copper homeostasis protein cutc BF25_RS10140 ENOG4107258 Transcriptional regulator BF25_RS10145 ENOG4105P4J Allophanate hydrolase, subunit 1 BF25_RS10185 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BF25_RS10235 ENOG4105F1N DNA alkylation repair BF25_RS10245 ENOG4108IQI permease BF25_RS10250 ENOG4105KNA -acetyltransferase BF25_RS10255 ENOG410635A Membrane BF25_RS10335 ENOG4108XET gCN5-related N-acetyltransferase BF25_RS10365 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF25_RS10375 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF25_RS10410 ENOG4105FS7 Transcriptional regulator BF25_RS10415 ENOG4108TVJ Nitroreductase BF25_RS10425 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF25_RS10465 ENOG4105C8Y Acetylornithine aminotransferase BF25_RS10475 ENOG4105CKK Glycosyl transferase, family 2 BF25_RS10500 ENOG4105CKK Glycosyl transferase, family 2 BF25_RS10510 ENOG4105CSH Transporter BF25_RS10525 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF25_RS10550 ENOG41068WN BF25_RS10560 ENOG4108WCX response regulator BF25_RS10570 ENOG41090T1 Membrane BF25_RS10585 ENOG4105VMP Transcriptional regulator BF25_RS10595 ENOG4105G6Z alkaline phosphatase BF25_RS10600 ENOG4105ECK Fatty Acid Desaturase BF25_RS10605 ENOG4105E0Y RtcB Protein BF25_RS10615 ENOG4107258 Transcriptional regulator BF25_RS10625 ENOG4105II7 pyrroline-5-carboxylate reductase BF25_RS10630 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BF25_RS10660 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BF25_RS10680 ENOG41061GT Aldolase BF25_RS10695 ENOG4105DKT Transcriptional regulator BF25_RS10705 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BF25_RS10715 ENOG4105D4B ABC, transporter BF25_RS10740 ENOG4105EMN RNA polymerase sigma factor BF25_RS10750 ENOG41069ER domain protein BF25_RS10765 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) BF25_RS10785 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BF25_RS10790 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BF25_RS10795 ENOG4105CIH Imidazole acetol-phosphate transaminase BF25_RS10815 ENOG41082JN Transcriptional regulator BF25_RS10820 ENOG4105EYF MMPL domain protein BF25_RS10830 ENOG4105EYF MMPL domain protein BF25_RS10840 ENOG4105C5H ABC transporter BF25_RS10845 ENOG4105E0M Sulfatase BF25_RS10850 ENOG4108ZCF integral membrane protein BF25_RS10870 ENOG4107VC0 DNA alkylation repair enzyme BF25_RS10920 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BF25_RS10940 ENOG4105E09 nadh pyrophosphatase BF25_RS10965 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BF25_RS10970 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BF25_RS10975 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BF25_RS10990 ENOG4105C02 permease BF25_RS11075 ENOG4105CHM Aminotransferase BF25_RS11110 ENOG41089UC methyltransferase, type 11 BF25_RS11125 ENOG4107BMA Transglycosylase associated protein BF25_RS11145 ENOG4106K7D Major facilitator family transporter BF25_RS11150 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF25_RS11190 ENOG4105EPR degv family BF25_RS11195 ENOG4105DPN Oligoendopeptidase f BF25_RS11235 ENOG4105BZU Histidine kinase BF25_RS11240 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BF25_RS11280 ENOG4105DTQ mandelate racemase muconate lactonizing BF25_RS11295 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BF25_RS11300 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF25_RS11315 ENOG4107T5V SNARE associated Golgi BF25_RS11355 ENOG41080HI glycine oxidase BF25_RS11360 ENOG4105CTU Proline racemase BF25_RS11365 ENOG4105CTU Proline racemase BF25_RS11370 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF25_RS11375 ENOG4105C26 Dehydrogenase BF25_RS11380 ENOG4105BZG amino acid carrier protein BF25_RS11395 ENOG4108M1A Chitin-binding protein BF25_RS11450 ENOG4105C9U ATP-dependent DNA helicase RecQ BF25_RS11470 ENOG4105EEM helicase BF25_RS11520 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF25_RS11565 ENOG4108M1A Chitin-binding protein BF25_RS11570 ENOG41082BV acetyltransferase BF25_RS11575 ENOG4105E66 phosphoriboisomerase A BF25_RS11600 ENOG4108IJ7 Glycine betaine BF25_RS11605 ENOG4107SQ8 Glycine betaine BF25_RS11640 ENOG4105RHY Pfam:UPF0157 BF25_RS11645 ENOG4105E1F short-chain dehydrogenase reductase BF25_RS11655 ENOG4107RUY (E1 component), alpha subunit BF25_RS11665 ENOG4107QKR Dehydrogenase BF25_RS11685 ENOG41062ES Transcriptional regulator BF25_RS11705 ENOG4105E98 transcriptional regulator DeoR family BF25_RS11725 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BF25_RS11755 ENOG4107Z3H Transcriptional regulator, TetR family BF25_RS11760 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BF25_RS11765 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BF25_RS11770 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BF25_RS11790 ENOG4105MSI germination protein ypeb BF25_RS11810 ENOG4108V3A UPF0421 protein BF25_RS11845 ENOG4105FDR Membrane BF25_RS11855 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF25_RS11880 ENOG4108IUM Glycogen debranching enzyme BF25_RS11895 ENOG4105DY8 decarboxylase BF25_RS11915 ENOG4105PAD Hydrolase BF25_RS11940 ENOG4107VFR oxidoreductase BF25_RS11980 ENOG4105PKS Excinuclease abc c subunit domain protein BF25_RS12015 ENOG4105KWG Pfam:DUF1696 BF25_RS12050 ENOG4108XI2 Domain of unknown function (DUF1963) BF25_RS12085 ENOG4108Z4K mutator MutT protein BF25_RS12090 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF25_RS12095 ENOG4105E09 nadh pyrophosphatase BF25_RS12110 ENOG4105FCD Major Facilitator BF25_RS12145 ENOG4107Y9U Membrane BF25_RS12165 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF25_RS12180 ENOG4107Y80 Major Facilitator superfamily BF25_RS12210 ENOG4108V4B ThiJ pfpI BF25_RS12245 ENOG4105FQP Beta-lactamase BF25_RS12255 ENOG4105CJN penicillin-binding protein BF25_RS12260 ENOG4105CB2 alcohol dehydrogenase BF25_RS12275 ENOG4108HGU Histidine kinase BF25_RS12285 ENOG4108JJB ABC transporter BF25_RS12305 ENOG4107RF6 penicillin-binding protein BF25_RS12310 ENOG4105BZU Histidine kinase BF25_RS12320 ENOG410667J hydrolase BF25_RS12430 ENOG4105ETU transcriptional activator (TenA BF25_RS12545 ENOG4105CPQ Dehydrogenase BF25_RS12580 ENOG4105CUV Homoserine Kinase BF25_RS12600 ENOG4107Y80 Major Facilitator superfamily BF25_RS12610 ENOG4105FQP Beta-lactamase BF25_RS12625 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF25_RS12625 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF25_RS12665 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BF25_RS12675 ENOG4105T9C HD domain BF25_RS12690 ENOG4105DZ1 carboxypeptidase BF25_RS12705 ENOG4105DBI uridine monophosphokinase BF25_RS12710 ENOG4105WCN acetyltransferase BF25_RS12720 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF25_RS12725 ENOG4107QX3 carboxylase BF25_RS12730 ENOG4105E39 Enoyl-CoA hydratase BF25_RS12735 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BF25_RS12740 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BF25_RS12745 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF25_RS12750 ENOG4105C1G acyl-Coa dehydrogenase BF25_RS12765 ENOG4107Z3H Transcriptional regulator, TetR family BF25_RS12775 ENOG4105CJ1 ABC, transporter BF25_RS12790 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BF25_RS12795 ENOG4105CEP NADH dehydrogenase BF25_RS12800 ENOG4106ANW SMI1_KNR4 BF25_RS12810 ENOG4105BZU Histidine kinase BF25_RS12820 ENOG4105C5H ABC transporter BF25_RS12825 ENOG41067SE Tetr family transcriptional regulator BF25_RS12845 ENOG4108VXD carboxy-peptidase BF25_RS12860 ENOG4105VZ8 Transcriptional regulator BF25_RS12895 ENOG4105DH8 myo-inositol catabolism BF25_RS12900 ENOG4105D2N Aldolase BF25_RS12925 ENOG4105CK5 oxidoreductase BF25_RS12930 ENOG4105IE8 Alpha-ketoglutarate permease BF25_RS12935 ENOG4105ETE Transcriptional regulator (LacI family BF25_RS12940 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF25_RS12955 ENOG4107RF6 penicillin-binding protein BF25_RS12980 ENOG4105CIN aminoacyl-histidine dipeptidase BF25_RS13020 ENOG41090HR transcriptional regulator BF25_RS13025 ENOG4107RA9 decarboxylase BF25_RS13030 ENOG4108I0C methyltransferase BF25_RS13040 ENOG41088CC tellurite resistance protein tehB BF25_RS13060 ENOG4108RZE Tetr family transcriptional regulator BF25_RS13075 ENOG4105C1J atp-dependent rna helicase BF25_RS13090 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF25_RS13110 ENOG4107STF Involved in phosphonate degradation (By similarity) BF25_RS13120 ENOG4105RD7 BadF BadG BcrA BcrD BF25_RS13170 ENOG4108KPJ rna polymerase sigma factor BF25_RS13175 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B BF25_RS13200 ENOG4108JCI Transcriptional regulator BF25_RS13220 ENOG4105BZ1 (ABC) transporter BF25_RS13225 ENOG4105BZ1 (ABC) transporter BF25_RS13240 ENOG4108RPX mosc domain containing protein BF25_RS13245 ENOG4105DND Transcriptional regulator BF25_RS13260 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF25_RS13265 ENOG4107V2S Transcriptional regulator BF25_RS13310 ENOG410667J hydrolase BF25_RS13330 ENOG4105VEQ Cold shock protein BF25_RS13340 ENOG41068WN BF25_RS13350 ENOG4105C1Q protoporphyrinogen oxidase BF25_RS13380 ENOG4105WCN acetyltransferase BF25_RS13405 ENOG4105EYF MMPL domain protein BF25_RS13415 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF25_RS13430 ENOG41081I9 integral membrane protein BF25_RS13460 ENOG4108D32 Methyltransferase BF25_RS13485 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF25_RS13500 ENOG4105C22 threonyL-tRNA synthetase BF25_RS13505 ENOG4105FE9 pseudouridine synthase BF25_RS13530 ENOG4105BZG amino acid carrier protein BF25_RS13550 ENOG4105K70 DNA-binding protein BF25_RS13565 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF25_RS13570 ENOG4105WQT MbtH domain protein BF25_RS13575 ENOG4105CEY Amp-dependent synthetase and ligase BF25_RS13580 ENOG4105WQI isochorismatase BF25_RS13585 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BF25_RS13590 ENOG4105E4F Isochorismate synthase BF25_RS13595 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BF25_RS13600 ENOG4105FCD Major Facilitator BF25_RS13630 ENOG4105EYH Exonuclease BF25_RS13635 ENOG4107RFY SbcCD D subunit BF25_RS13650 ENOG4105E39 Enoyl-CoA hydratase BF25_RS13655 ENOG4105N14 lysine exporter protein LysE YggA BF25_RS13665 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF25_RS13670 ENOG4105C1G acyl-Coa dehydrogenase BF25_RS13675 ENOG4105CR4 methylisocitrate lyase BF25_RS13680 ENOG4105DXD 2-methylcitrate dehydratase BF25_RS13690 ENOG4105W8X HesB YadR YfhF-family protein BF25_RS13695 ENOG4105CZM Major Facilitator BF25_RS13700 ENOG4105BZ4 penicillin-binding protein BF25_RS13740 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF25_RS13845 ENOG4108IBT Inherit from COG: transposase BF25_RS13860 ENOG4105SZ6 Thioredoxin BF25_RS13870 ENOG410841Q phosphoesterase PA-phosphatase related protein BF25_RS13875 ENOG4108N23 SpoOM-related protein BF25_RS13915 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BF25_RS13920 ENOG4108JUB Transcriptional regulator BF25_RS13925 ENOG4108TSC N-acetyltransferase BF25_RS13930 ENOG4107S4Y M20 DapE family protein YgeY BF25_RS13945 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF25_RS13970 ENOG4105C37 (CBS) domain BF25_RS14005 ENOG4105E90 ABC transporter BF25_RS14010 ENOG4108IJ8 ABC transporter BF25_RS14040 ENOG4105CMG Carbohydrate kinase BF25_RS14045 ENOG4105CMG Carbohydrate kinase BF25_RS14090 ENOG4105WH1 Two component transcriptional regulator luxr family BF25_RS14095 ENOG4105BZU Histidine kinase BF25_RS14100 ENOG4105D8X mechanosensitive ion channel BF25_RS14135 ENOG4105F0I Aminotransferase BF25_RS14140 ENOG4108MES Periplasmic binding protein BF25_RS14160 ENOG4105CAQ asparagine synthetase BF25_RS14165 ENOG4107Y70 Heat shock protein BF25_RS14170 ENOG4108KF3 Electron transport protein SCO1 SenC BF25_RS14175 ENOG4105E8R UPF0173 metal-dependent hydrolase BF25_RS14180 ENOG4108RCR degv family BF25_RS14190 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BF25_RS14200 ENOG4108UT2 hemolysin iii BF25_RS14205 ENOG4105E9Q Acyl-transferase BF25_RS14210 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF25_RS14215 ENOG4107RVG penicillin-binding protein BF25_RS14230 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BF25_RS14250 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BF25_RS14280 ENOG4105KD7 acetyltransferase BF25_RS14295 ENOG4105C0A alcohol dehydrogenase BF25_RS14300 ENOG4105CY2 Citrate transporter BF25_RS14305 ENOG4107XGZ Hydrolase BF25_RS14325 ENOG4105C8J )-transporter BF25_RS14340 ENOG41062D9 Histidine kinase BF25_RS14345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_RS14350 ENOG4107QPK )-transporter BF25_RS14355 ENOG4105BZW Glycerate kinase BF25_RS14450 ENOG4105EC2 ftsk spoIIIe BF25_RS14470 ENOG4105C5S asparaginyl-tRNA synthetase BF25_RS14490 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF25_RS14515 ENOG4105C75 arginyL-tRNA synthetase BF25_RS14520 ENOG4107YX5 Pfam:DUF548 BF25_RS14555 ENOG4108UUM single-stranded DNA-binding protein BF25_RS14570 ENOG4105C5H ABC transporter BF25_RS14590 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF25_RS14605 ENOG4105MCT stage V sporulation protein S BF25_RS14640 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BF25_RS14645 ENOG4108IFG nitrite reductase, (NAD(P)H) BF25_RS14650 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BF25_RS14655 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF25_RS14660 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF25_RS14665 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF25_RS14690 ENOG4108ZAF Molybdopterin BF25_RS14695 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF25_RS14700 ENOG4105D06 uba thif-type nad fad binding protein BF25_RS14705 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF25_RS14710 ENOG4107V6Q Cyclic nucleotide-binding domain BF25_RS14735 ENOG4105R3A Nitrate reductase BF25_RS14740 ENOG4108IUE nitrate reductase beta subunit BF25_RS14760 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF25_RS14775 ENOG4108V06 Glutathione peroxidase BF25_RS14800 ENOG4105EMN RNA polymerase sigma factor BF25_RS14805 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BF25_RS14815 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BF25_RS14840 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF25_RS14865 ENOG4105KBJ sporulation protein ytfj BF25_RS14915 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF25_RS14940 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF25_RS14945 ENOG4108JYZ YitT family BF25_RS14950 ENOG41087PP glycosyltransferase MGT family BF25_RS14970 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF25_RS14980 ENOG4108X4Q Hydrolase BF25_RS15005 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF25_RS15015 ENOG4108VXD carboxy-peptidase BF25_RS15025 ENOG4108ZRV stage ii sporulation protein p BF25_RS15045 ENOG4108Z7R Chaperone CsaA BF25_RS15065 ENOG4105C37 (CBS) domain BF25_RS15070 ENOG4105SXS Protein of unknown function (DUF456) BF25_RS15090 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF25_RS15095 ENOG4108S4H thioesterase Superfamily protein BF25_RS15105 ENOG4108PJD permease BF25_RS15120 ENOG4107T5V SNARE associated Golgi BF25_RS15140 ENOG4105CVJ phosphoglycerate mutase BF25_RS15165 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF25_RS15175 ENOG4105K4T epimerase BF25_RS15185 ENOG4105DSE periplasmic solute binding protein BF25_RS15255 ENOG4105CKI cobalamin synthesis protein BF25_RS15260 ENOG4107QM2 Aldo Keto reductase BF25_RS15280 ENOG4105DEN Luciferase family BF25_RS15295 ENOG4108WPJ Ferritin-like domain BF25_RS15300 ENOG4108K88 Membrane BF25_RS15320 ENOG4105C8Q Methyl-accepting chemotaxis BF25_RS15345 ENOG4107XZQ multidrug resistance protein BF25_RS15350 ENOG4107SET aldo keto reductase BF25_RS15355 ENOG4105YVS arsR family transcriptional regulator BF25_RS15365 ENOG4105KRN Transcriptional regulator, abrb family BF25_RS15415 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BF25_RS15425 ENOG4105YWU small acid-soluble spore protein BF25_RS15430 ENOG4108WBH protein TIM barrel BF25_RS15445 ENOG4105CEY Amp-dependent synthetase and ligase BF25_RS15450 ENOG4105DUU IucA IucC family protein BF25_RS15460 ENOG4105VRR gCN5-related N-acetyltransferase BF25_RS15465 ENOG4105KT7 mgtC SapB transporter BF25_RS15480 ENOG4105BZU Histidine kinase BF25_RS15485 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF25_RS15495 ENOG4108KGH TRANSCRIPTIONal BF25_RS15520 ENOG4105D6E homoserine dehydrogenase BF25_RS15545 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BF25_RS15565 ENOG4105BZU Histidine kinase BF25_RS15570 ENOG4105EFI regulatoR BF25_RS15625 ENOG4108JJ8 (ABC) transporter BF25_RS15630 ENOG4108JJ9 ABC, transporter BF25_RS15635 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF25_RS15640 ENOG4105C4M (Ubiquinol oxidase) subunit I BF25_RS15650 ENOG4105YGB Transcriptional regulator BF25_RS15670 ENOG4105SKE transcriptional Regulator LysR family BF25_RS15680 ENOG4105C32 Amino acid ABC transporter (Permease) BF25_RS15685 ENOG4108IV0 ABC, transporter BF25_RS15690 ENOG4105C0Z ABC transporter BF25_RS15700 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF25_RS15705 ENOG4108Z7G MaoC domain protein dehydratase BF25_RS15725 ENOG4105CKI cobalamin synthesis protein BF25_RS15740 ENOG4106F5Q Membrane BF25_RS15745 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF25_RS15755 ENOG4108TVJ Nitroreductase BF25_RS15760 ENOG4107ZXU DSBA oxidoreductase BF25_RS15765 ENOG4108Z40 Transcriptional regulator BF25_RS15770 ENOG4105GZI Transcriptional regulator BF25_RS15775 ENOG4107RT3 EamA-like transporter family BF25_RS15785 ENOG4105KTB nuclear export factor GLE1 BF25_RS15790 ENOG4108T5E Copper resistance protein BF25_RS15835 ENOG4107STQ Multicopper oxidase BF25_RS15840 ENOG4107RAQ aminopeptidase BF25_RS15875 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BF25_RS15880 ENOG4105D9N nucleoside BF25_RS15890 ENOG4107RHR regulatoR BF25_RS15925 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BF25_RS15940 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BF25_RS15960 ENOG41068WN BF25_RS15995 ENOG4105F6J Alpha beta hydrolase fold BF25_RS16015 ENOG4105CYC Transferase BF25_RS16020 ENOG4105DY9 regulatoR BF25_RS16030 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BF25_RS16035 ENOG4105C6X Major Facilitator BF25_RS16060 ENOG4105C7B Threonine dehydratase BF25_RS16070 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF25_RS16075 ENOG4108ZP8 Acetolactate synthase small subunit BF25_RS16080 ENOG4105C7K acetolactate synthase BF25_RS16085 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF25_RS16090 ENOG4105CHR reductase BF25_RS16095 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BF25_RS16110 ENOG4106KE4 Dehydrogenase BF25_RS16125 ENOG4105H67 Protein of unknown function (DUF421) BF25_RS16130 ENOG4105X5K response regulator receiver protein BF25_RS16140 ENOG4105C8J )-transporter BF25_RS16160 ENOG4105C6T cysteine synthase BF25_RS16165 ENOG4105EU0 Major facilitator Superfamily BF25_RS16180 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF25_RS16200 ENOG4105CSR polyphosphate kinase 2 BF25_RS16240 ENOG4105FVX BF25_RS16310 ENOG4105C6K Malic enzyme BF25_RS16315 ENOG4108IJ0 Aspartate ammonia-lyase BF25_RS16325 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BF25_RS16345 ENOG4105CJ1 ABC, transporter BF25_RS16380 ENOG4106BRA Membrane BF25_RS16415 ENOG4107QIV Cytochrome c biogenesis protein BF25_RS16435 ENOG4105EC3 peptidase S51, dipeptidase E BF25_RS16465 ENOG4105C9Q fumarate hydratase class II BF25_RS16470 ENOG4105DFD Na H antiporter BF25_RS16485 ENOG4108PJD permease BF25_RS16490 ENOG4105CKI cobalamin synthesis protein BF25_RS16495 ENOG4108UZ3 Transporter BF25_RS16500 ENOG4105DRR Transcriptional regulator, GntR family BF25_RS16510 ENOG4105PGM cation diffusion facilitator family transporter BF25_RS16530 ENOG4105CAQ asparagine synthetase BF25_RS16560 ENOG4105CVJ phosphoglycerate mutase BF25_RS16595 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BF25_RS16600 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BF25_RS16605 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF25_RS16610 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF25_RS16640 ENOG4105KAC Antibiotic biosynthesis monooxygenase BF25_RS16660 ENOG4108RZE Tetr family transcriptional regulator BF25_RS16685 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF25_RS16690 ENOG4105KTQ flagellar basal-body rod protein BF25_RS16700 ENOG4105D7B Flagellar biosynthesis protein flha BF25_RS16705 ENOG4105D00 flagellar biosynthetic protein flhB BF25_RS16715 ENOG4105VS8 Flagellar biosynthetic protein fliq BF25_RS16720 ENOG4105CN7 Flagellar biosynthetic protein FliP BF25_RS16730 ENOG4105DD5 Flagellar motor switch protein BF25_RS16745 ENOG4105E4C Lytic transglycosylase catalytic BF25_RS16750 ENOG4105I03 Flagellin BF25_RS16805 ENOG4105K64 Glycosyl transferase, family 2 BF25_RS16830 ENOG4105BZE flagellar hook protein, FlgE BF25_RS16865 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF25_RS16885 ENOG4108ZC9 flagellar basal-body rod protein flgc BF25_RS16890 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BF25_RS16920 ENOG4105E1Q flagellar hook-associated protein BF25_RS16940 ENOG4105BZU Histidine kinase BF25_RS16955 ENOG4105DD5 Flagellar motor switch protein BF25_RS16960 ENOG4105CBS Chea signal transduction histidine kinase BF25_RS16965 ENOG4107YTP response regulator receiver protein BF25_RS16970 ENOG4105ER2 Ompa motb domain protein BF25_RS16975 ENOG4107R0U MotA TolQ exbB proton channel BF25_RS16985 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF25_RS17040 ENOG41080C8 DUF218 domain BF25_RS17045 ENOG4105H67 Protein of unknown function (DUF421) BF25_RS17055 ENOG4108Z5V transcriptional regulator, merr family BF25_RS17065 ENOG4107RWR Sodium hydrogen exchanger BF25_RS17075 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF25_RS17140 ENOG41081VK Ribonuclease BF25_RS17160 ENOG4108SZE gCN5-related N-acetyltransferase BF25_RS17250 ENOG4105KHC sulfurtransferase BF25_RS17260 ENOG4108W0I acetyltransferase BF25_RS17270 ENOG410890F Dynamin family BF25_RS17275 ENOG4105DHF Membrane BF25_RS17280 ENOG4105C2W permease BF25_RS17290 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF25_RS17305 ENOG4105CTD carboxy-peptidase BF25_RS17310 ENOG4105DVT helicase BF25_RS17320 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BF25_RS17370 ENOG4105BZ4 penicillin-binding protein BF25_RS17380 ENOG4105CSM endonuclease III BF25_RS17400 ENOG4105YAC BF25_RS17405 ENOG4105DVT helicase BF25_RS17445 ENOG4105CPK Glycosyl transferase (Group 1 BF25_RS17450 ENOG4105FJR Lmbe family BF25_RS17465 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BF25_RS17470 ENOG4108JYZ YitT family BF25_RS17500 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BF25_RS17505 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BF25_RS17510 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BF25_RS17525 ENOG41068YB TPR repeat-containing protein BF25_RS17530 ENOG4105CIH Imidazole acetol-phosphate transaminase BF25_RS17550 ENOG4105EAH synthase BF25_RS17560 ENOG4105XXQ heptaprenyl diphosphate synthase component I BF25_RS17575 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BF25_RS17605 ENOG41065D1 BF25_RS17610 ENOG4105S2F BF25_RS17645 ENOG4105HDK L-asparaginase BF25_RS17650 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BF25_RS17675 ENOG4108S6Z Negative regulator of genetic competence BF25_RS17680 ENOG4107X2D transcriptional regulator, merr family BF25_RS17695 ENOG4105I7S Abortive infection protein BF25_RS17700 ENOG4105C9U ATP-dependent DNA helicase RecQ BF25_RS17705 ENOG4105T7X BF25_RS17715 ENOG4108SAX Membrane BF25_RS17730 ENOG4108WBT adenosyltransferase BF25_RS17735 ENOG4105BZU Histidine kinase BF25_RS17740 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_RS17745 ENOG4105CRE cytochrome C BF25_RS17750 ENOG4107TWT Cytochrome c biogenesis protein BF25_RS17760 ENOG4105FE9 pseudouridine synthase BF25_RS17770 ENOG4108JIC nucleoside recognition domain protein BF25_RS17775 ENOG4105DZ1 carboxypeptidase BF25_RS17780 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF25_RS17815 ENOG4105BZU Histidine kinase BF25_RS17830 ENOG4105I3N Conserved Protein BF25_RS17850 ENOG4105BZ4 penicillin-binding protein BF25_RS17855 ENOG4107GRR phosphate transport regulator BF25_RS17860 ENOG4105CJ3 phosphate transporter BF25_RS17885 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BF25_RS17910 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BF25_RS17930 ENOG4105WH1 Two component transcriptional regulator luxr family BF25_RS17935 ENOG4105ENE Histidine kinase BF25_RS17955 ENOG4105DFD Na H antiporter BF25_RS17975 ENOG4105C8J )-transporter BF25_RS17985 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF25_RS17990 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF25_RS17995 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF25_RS18005 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BF25_RS18010 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BF25_RS18030 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BF25_RS18040 ENOG4105E0M Sulfatase BF25_RS18045 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF25_RS18060 ENOG4107RVV histidinol phosphate phosphatase, hisj family BF25_RS18095 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BF25_RS18120 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BF25_RS18130 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF25_RS18135 ENOG4108ZP8 Acetolactate synthase small subunit BF25_RS18140 ENOG4105C7K acetolactate synthase BF25_RS18145 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF25_RS18175 ENOG4105KBJ sporulation protein ytfj BF25_RS18180 ENOG41063Y9 BF25_RS18185 ENOG4105CZN Potassium uptake protein BF25_RS18215 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF25_RS18220 ENOG4107QMU Mate efflux family protein BF25_RS18255 ENOG4105NQC Flavodoxin BF25_RS18280 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF25_RS18290 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF25_RS18295 ENOG4105EA8 2-Nitropropane dioxygenase BF25_RS18300 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF25_RS18340 ENOG4105CJ1 ABC, transporter BF25_RS18350 ENOG4105CZV ABC transporter BF25_RS18355 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF25_RS18360 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF25_RS18380 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BF25_RS18425 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BF25_RS18430 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BF25_RS18440 ENOG4105BZU Histidine kinase BF25_RS18450 ENOG4106DF1 BF25_RS18460 ENOG41090MY MarR family Transcriptional regulator BF25_RS18465 ENOG4105BZU Histidine kinase BF25_RS18475 ENOG4105PXI polysaccharide deacetylase BF25_RS18500 ENOG4105E98 transcriptional regulator DeoR family BF25_RS18530 ENOG4105C4Y ABC transporter BF25_RS18550 ENOG4105MWK D-amino acid dehydrogenase, small subunit BF25_RS18560 ENOG4105CHR reductase BF25_RS18580 ENOG4108Z7G MaoC domain protein dehydratase BF25_RS18585 ENOG410681C small acid-soluble spore protein BF25_RS18590 ENOG4105CZN Potassium uptake protein BF25_RS18595 ENOG4107TS3 membrane protein, TerC BF25_RS18600 ENOG4108QTI )-transporter BF25_RS18610 ENOG4106A3R peptidase BF25_RS18630 ENOG4105JXH GntR family transcriptional regulator BF25_RS18635 ENOG4105BZU Histidine kinase BF25_RS18640 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_RS18655 ENOG4105CQB FAD linked oxidase domain protein BF25_RS18660 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BF25_RS18665 ENOG4105K4I Scp-like extracellular BF25_RS18675 ENOG4108YBP pseudouridine synthase BF25_RS18685 ENOG4105EYF MMPL domain protein BF25_RS18695 ENOG4107RUE extracellular solute-binding protein family 1 BF25_RS18700 ENOG4105D38 putrescine abc transporter BF25_RS18705 ENOG4105F38 ABC transporter, permease BF25_RS18710 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF25_RS18715 ENOG4105C26 Dehydrogenase BF25_RS18750 ENOG4105VFR signal peptidase BF25_RS18755 ENOG4105DZ1 carboxypeptidase BF25_RS18765 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BF25_RS18825 ENOG4105VZ8 Transcriptional regulator BF25_RS18835 ENOG4105C7S Dehydrogenase BF25_RS18925 ENOG4105DDQ anthranilate synthase BF25_RS18940 ENOG4105CK7 Sodium proline symporter BF25_RS19015 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BF25_RS19025 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BF25_RS19030 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BF25_RS19050 ENOG4107TVC Glycosyl transferase, family 2 BF25_RS19070 ENOG4105K64 Glycosyl transferase, family 2 BF25_RS19090 ENOG4105EMS pseudouridine synthase BF25_RS19110 ENOG4105MIX Adenylate cyclase BF25_RS19115 ENOG4108Z18 K06886 hemoglobin BF25_RS19130 ENOG4105DPN Oligoendopeptidase f BF25_RS19140 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF25_RS19150 ENOG4108ZCF integral membrane protein BF25_RS19175 ENOG4105UQX Mate efflux family protein BF25_RS19180 ENOG4108JQ7 (ABC) transporter BF25_RS19190 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF25_RS19195 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF25_RS19210 ENOG4105C31 Tryptophanyl-tRNA synthetase BF25_RS19225 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BF25_RS19230 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF25_RS19255 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BF25_RS19270 ENOG4108KP7 hydrolase BF25_RS19280 ENOG41073B9 BF25_RS19285 ENOG4107AYK membrAne BF25_RS19295 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF25_RS19305 ENOG4105QNR S1 RNA binding domain protein BF25_RS19335 ENOG4105CH6 catalase BF25_RS19340 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BF25_RS19345 ENOG4105CAQ asparagine synthetase BF25_RS19370 ENOG4105ERH Fumarylacetoacetate hydrolase BF25_RS19415 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BF25_RS19420 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BF25_RS19435 ENOG4105XVF Competence transcription factor BF25_RS19465 ENOG4107QP3 malate synthase g BF25_RS19490 ENOG4105C8Q Methyl-accepting chemotaxis BF25_RS19495 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BF25_RS19520 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF25_RS19540 ENOG41086D8 Transcriptional regulator BF25_RS19545 ENOG4108AEY RNA polymerase sigma factor BF25_RS19555 ENOG4107TVP HD domain protein BF25_RS19605 ENOG4105CNA YD repeat protein BF25_RS19635 ENOG4105CEY Amp-dependent synthetase and ligase BF25_RS19645 ENOG4105DF9 Lipoate-protein, ligase BF25_RS19650 ENOG4108RQ5 Beta-lactamase domain-containing protein BF25_RS19655 ENOG4106AXD BF25_RS19685 ENOG4105ECB domain protein BF25_RS19700 ENOG4105NA0 Transcriptional regulator BF25_RS19725 ENOG4105C1Q protoporphyrinogen oxidase BF25_RS19735 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BF25_RS19740 ENOG4105BZ4 penicillin-binding protein BF25_RS19745 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BF25_RS19750 ENOG4105CKV Membrane BF25_RS19755 ENOG410905X membrane-flanked domain protein BF25_RS19810 ENOG410905X membrane-flanked domain protein BF25_RS19840 ENOG4105K59 histidine triad (HIT) protein BF25_RS19870 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF25_RS19875 ENOG4105EEM helicase BF25_RS19885 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF25_RS19890 ENOG4105C57 major facilitator superfamily BF25_RS19915 ENOG4105EMN RNA polymerase sigma factor BF25_RS19930 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BF25_RS19945 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF25_RS19965 ENOG4108MUZ hydrolase BF25_RS19985 ENOG4105EQ0 Major Facilitator superfamily BF25_RS19990 ENOG4108IND Tetr family transcriptional regulator BF25_RS20005 ENOG4105D7V transposase BF25_RS20010 ENOG4106D4I domain protein BF25_RS20015 ENOG4107VRP DNA repair exonuclease BF25_RS20075 ENOG4105BZU Histidine kinase BF25_RS20080 ENOG4105BZU Histidine kinase BF25_RS20085 ENOG4108MJI response regulator BF25_RS20095 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF25_RS20105 ENOG4105WN5 stage II sporulation protein BF25_RS20170 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BF25_RS20195 ENOG410847I Transcriptional regulator, BadM Rrf2 family BF25_RS20200 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF25_RS20215 ENOG4105CMT Dihydroxyacetone kinase BF25_RS20235 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF25_RS20255 ENOG4108IG5 Transcriptional regulator BF25_RS20260 ENOG4107P5I polyketide synthase BF25_RS20310 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF25_RS20350 ENOG4105CDU Replicative dna helicase BF25_RS20400 ENOG4108MRH transcriptional regulatory protein BF25_RS20410 ENOG4105CSH Transporter BF25_RS20440 ENOG4108JQ7 (ABC) transporter BF25_RS20450 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF25_RS20495 ENOG4105CTU Proline racemase BF25_RS20515 ENOG4105DER m42 family BF25_RS20535 ENOG4105CGU Enoyl-CoA hydratase BF25_RS20550 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF25_RS20555 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF25_RS20565 ENOG4106AKK s-layer domain-containing protein BF25_RS20605 ENOG4105CHH sulfate transporter BF25_RS20620 ENOG4105D4P Coproporphyrinogen iii oxidase BF25_RS20650 ENOG4107FQX Alpha-acetolactate decarboxylase BF25_RS20685 ENOG410839P BF25_RS20700 ENOG4105CDA abc transporter atp-binding protein BF25_RS20705 ENOG4105DRP amino acid AbC transporter BF25_RS20720 ENOG4105BZ1 (ABC) transporter BF25_RS20730 ENOG4105C26 Dehydrogenase BF25_RS20740 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BF25_RS20745 ENOG4105D5Q Arginine ornithine antiporter BF25_RS20755 ENOG4105CH6 catalase BF25_RS20760 ENOG4107RKG DJ-1/PfpI family BF25_RS20770 ENOG4105E5W Transporter BF25_RS20775 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF25_RS20780 ENOG4105NF4 modulator of drug activity BF25_RS20805 ENOG4105KPY Small multidrug resistance protein BF25_RS20820 ENOG4108YXU transcriptional regulator AsnC family BF25_RS20825 ENOG4108PCN EamA-like transporter family BF25_RS20860 ENOG4106KNT transcriptional regulator BF25_RS20870 ENOG4107RWR Sodium hydrogen exchanger BF25_RS20875 ENOG4105CUB amino acid BF25_RS20910 ENOG4107T5V SNARE associated Golgi BF25_RS20945 ENOG4105WEF catalase BF25_RS20975 ENOG4105C19 ABC transporter BF25_RS20980 ENOG4107RBB ABC transporter, permease BF25_RS20985 ENOG41069ER domain protein BF25_RS21005 ENOG4105VZJ PTS System BF25_RS21010 ENOG4105VCP PTS System BF25_RS21015 ENOG4105EMD TRANSCRIPTIONal BF25_RS21040 ENOG4108KGH TRANSCRIPTIONal BF25_RS21050 ENOG41087NI Sulfite exporter TauE/SafE BF25_RS21055 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BF25_RS21065 ENOG41085GJ domain protein BF25_RS21070 ENOG4105VFE sira family BF25_RS21075 ENOG4107TPS domain protein BF25_RS21080 ENOG4105VFE sira family BF25_RS21085 ENOG4105XTG Pfam:DUF156 BF25_RS21090 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BF25_RS21115 ENOG4105ED1 spovr family BF25_RS21120 ENOG4107Y03 Nitroreductase BF25_RS21180 ENOG4105C5Y PTS System BF25_RS21210 ENOG4105C7N Xanthine uracil vitamin C permease BF25_RS21225 ENOG4108INS Transcriptional regulator BF25_RS21280 ENOG4105DWF phosphomethylpyrimidine kinase BF25_RS21285 ENOG4105D06 uba thif-type nad fad binding protein BF25_RS21300 ENOG41080HI glycine oxidase BF25_RS21305 ENOG4108VEU Thiamine monophosphate synthase BF25_RS21315 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF25_RS21325 ENOG4105ETU transcriptional activator (TenA BF25_RS21350 ENOG41080XQ Signal transduction protein with cbs domains BF25_RS21480 ENOG4105E2Z phosphate ABC transporter (Permease BF25_RS21485 ENOG4105C8U phosphate abc transporter BF25_RS21490 ENOG4105CVA phosphate BF25_RS21495 ENOG4105CE1 Ferrous iron transport protein b BF25_RS21500 ENOG4105CE1 Ferrous iron transport protein b BF25_RS21505 ENOG4105CE1 Ferrous iron transport protein b BF25_RS21515 ENOG4108NHD germination protein BF25_RS21530 ENOG4105E1V na solute symporter BF25_RS21535 ENOG4106CAD Protein of unknown function (DUF3311) BF25_RS21550 ENOG4108IQI permease BF25_RS21555 ENOG4105E2S oxidase) subunit II BF25_RS21560 ENOG4105BZ9 Cytochrome C oxidase, subunit I BF25_RS21600 ENOG4105C7N Xanthine uracil vitamin C permease BF25_RS21605 ENOG4105C85 amino acid BF25_RS21625 ENOG4105DUX Transporter BF25_RS21635 ENOG4107D63 BF25_RS21640 ENOG4105VZ8 Transcriptional regulator BF25_RS21645 ENOG41069ER domain protein BF25_RS21650 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF25_RS21655 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF25_RS21720 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BF25_RS21725 ENOG4105CNN ABC, transporter BF25_RS21740 ENOG4108RVA ribokinase BF25_RS21745 ENOG4105ETE Transcriptional regulator (LacI family BF25_RS21760 ENOG41067TZ transcriptional regulator, MarR family BF25_RS21765 ENOG4105CXY transporter BF25_RS21775 ENOG4108JQ7 (ABC) transporter BF25_RS21780 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF25_RS21790 ENOG4105DEF Extracellular solute-binding protein, family 5 BF25_RS21800 ENOG41068KF Universal stress protein BF25_RS21805 ENOG4105CHH sulfate transporter BF25_RS21815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_RS21820 ENOG4105BZU Histidine kinase BF25_RS21825 ENOG4105NAE bifunctional deaminase-reductase domain protein BF25_RS21830 ENOG4105D29 Helix-turn-helix type 11 domain protein BF25_RS21855 ENOG4108IQI permease BF25_RS21860 ENOG4105DRP amino acid AbC transporter BF25_RS21865 ENOG4105EAD ABC transporter BF25_RS21870 ENOG4105CT1 (ABC) transporter BF25_RS21875 ENOG4105CDA abc transporter atp-binding protein BF25_RS21880 ENOG4105BZG amino acid carrier protein BF25_RS21885 ENOG4105CRN Aminoglycoside phosphotransferase BF25_RS21895 ENOG4105E1K spore germination protein BF25_RS21910 ENOG4105CG3 alpha amylase, catalytic region BF25_RS21915 ENOG4105C5Y PTS System BF25_RS21920 ENOG4107414 GntR family transcriptional regulator BF25_RS21925 ENOG4105D5Q Arginine ornithine antiporter BF25_RS21930 ENOG4105BZU Histidine kinase BF25_RS21945 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF25_RS21950 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BF25_RS21955 ENOG4107T89 von Willebrand factor, type A BF25_RS21965 ENOG4105EXW epimerase dehydratase BF25_RS21975 ENOG4105DMQ Methyltransferase BF25_RS21980 ENOG4105E0A ABC, transporter BF25_RS21985 ENOG4108IHU transport system permease protein BF25_RS21990 ENOG4105DQ5 transport system permease protein BF25_RS21995 ENOG4108MES Periplasmic binding protein BF25_RS22000 ENOG4105DUX Transporter BF25_RS22015 ENOG4105DAA L-lactate BF25_RS22020 ENOG4108IJ0 Aspartate ammonia-lyase BF25_RS22025 ENOG4105C37 (CBS) domain BF25_RS22030 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BF25_RS22035 ENOG4105D9N nucleoside BF25_RS22040 ENOG4108KGH TRANSCRIPTIONal BF25_RS22045 ENOG41073R8 VanW family BF25_RS22075 ENOG4105DAP Nicotinate phosphoribosyltransferase BF25_RS22080 ENOG4105C59 p-type ATPase BF25_RS22090 ENOG4105CUB amino acid BF25_RS22110 ENOG4108JB9 formate dehydrogenase BF25_RS22115 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF25_RS22120 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF25_RS22130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_RS22135 ENOG4105BZU Histidine kinase BF25_RS22145 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF25_RS22150 ENOG4108UZ3 Transporter BF25_RS22160 ENOG4105C6K Malic enzyme BF25_RS22170 ENOG4108MRH transcriptional regulatory protein BF25_RS22195 ENOG4105US7 Histidine kinase BF25_RS22200 ENOG4108STX response regulator BF25_RS22205 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BF25_RS22210 ENOG4105BZ7 extracellular solute-binding protein family 1 BF25_RS22215 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BF25_RS22220 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BF25_RS22225 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF25_RS22230 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF25_RS22250 ENOG4105D4T Citrate transporter BF25_RS22260 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BF25_RS22270 ENOG4105DZ6 Band 7 protein BF25_RS22285 ENOG4105C94 Transporter BF25_RS22310 ENOG4105CYN Serine protein kinase BF25_RS22320 ENOG4105BZU Histidine kinase BF25_RS22325 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BF25_RS22335 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BF25_RS22345 ENOG4107ZQN disulfide bond BF25_RS22350 ENOG4108JQC penicillin-binding protein 1A BF25_RS22465 ENOG4105G5W regulator Fur family BF25_RS22470 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF25_RS22490 ENOG4108IUW ABC transporter BF25_RS22500 ENOG4105CBC glutamate synthase BF25_RS22505 ENOG4107NBY Membrane BF25_RS22510 ENOG4105BZ1 (ABC) transporter BF25_RS22530 ENOG4106BXE BF25_RS22535 ENOG4105CEN a g-specific adenine glycosylase BF25_RS22540 ENOG41067AE Membrane-bound metal-dependent hydrolase BF25_RS22570 ENOG4105ECP epimerase BF25_RS22575 ENOG4105CI2 imidazolone-5-propionate hydrolase BF25_RS22595 ENOG4105F1A Pyruvate formate-lyase BF25_RS22615 ENOG4105C3I Nad-dependent epimerase dehydratase BF25_RS22620 ENOG4107QQG Dehydrogenase BF25_RS22630 ENOG4105CKK Glycosyl transferase, family 2 BF25_RS22645 ENOG4108A04 Beta-lactamase BF25_RS22690 ENOG4108IQI permease BF25_RS22700 ENOG4108JUB Transcriptional regulator BF25_RS22710 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF25_RS22985 ENOG4108IMY Transcriptional regulator BF25_RS22990 ENOG4105VTR Integrase BF25_RS22995 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF25_RS23035 ENOG4105UPD Calcium Proton BF25_RS23040 ENOG410606W general stress protein BF25_RS23055 ENOG4107ZTW SNARE associated Golgi BF25_RS23075 ENOG4108IPJ Membrane BF25_RS23080 ENOG4105C59 p-type ATPase BF25_RS23085 ENOG4107U9T Pfam:Ribonuclease_BN BF25_RS23095 ENOG4105KJF protein tyrosine phosphatase BF25_RS23115 ENOG4108TTB tellurium resistance protein BF25_RS23120 ENOG4107TS3 membrane protein, TerC BF25_RS23125 ENOG4106FN3 tellurium resistance protein BF25_RS23130 ENOG4106FN3 tellurium resistance protein BF25_RS23135 ENOG4108N0M stress protein BF25_RS23150 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) BF25_RS23165 ENOG4105DEU major facilitator superfamily BF25_RS23185 ENOG41062JF Transcriptional regulator BF25_RS23210 ENOG4105C5H ABC transporter BF25_RS23225 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF25_RS23240 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BF25_RS23270 ENOG4105CI1 PTS System BF25_RS23280 ENOG4105C8Q Methyl-accepting chemotaxis BF25_RS23285 ENOG4105C8Q Methyl-accepting chemotaxis BF25_RS23295 ENOG4105EAB amino acid AbC transporter BF25_RS23300 ENOG4105E5Q amino acid AbC transporter BF25_RS23315 ENOG4105D2S major facilitator superfamily BF25_RS23320 ENOG410756H nucleotidyltransferase BF25_RS23340 ENOG4105BZU Histidine kinase BF25_RS23365 ENOG4106UIA BF25_RS23370 ENOG4106UIA BF25_RS23395 ENOG4108V5C ABC transporter BF25_RS23400 ENOG4105DQ5 transport system permease protein BF25_RS23405 ENOG4105EHG Permease protein BF25_RS23425 ENOG4105D3R alkyl hydroperoxide reductase BF25_RS23445 ENOG4105DFD Na H antiporter BF25_RS23455 ENOG4105DTQ mandelate racemase muconate lactonizing BF25_RS23470 ENOG4108W15 Protein of unknown function (DUF1456) BF25_RS23485 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF25_RS23490 ENOG4105D9N nucleoside BF25_RS23510 ENOG4105KPY Small multidrug resistance protein BF25_RS23515 ENOG4105C26 Dehydrogenase BF25_RS23525 ENOG4108JPW Aminotransferase BF25_RS23530 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BF25_RS23535 ENOG4105CBD Diacylglycerol kinase BF25_RS23560 ENOG410834F Transcriptional regulator BF25_RS23580 ENOG4105D01 (LipO)protein BF25_RS23585 ENOG4108UMI ABC transporter, permease BF25_RS23590 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF25_RS23595 ENOG4108W2Y isochorismatase BF25_RS23625 ENOG4105C4R Atp-dependent dna helicase BF25_RS23650 ENOG4105C12 Phosphoribosylglycinamide synthetase BF25_RS23660 ENOG4108V3E phosphoribosylglycinamide formyltransferase BF25_RS23685 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BF25_RS23695 ENOG4105C83 adenylosuccinate lyase BF25_RS23700 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BF25_RS23705 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BF25_RS23730 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF25_RS23750 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF25_RS23790 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF25_RS23830 ENOG4105BZU Histidine kinase BF25_RS23840 ENOG4105C7N Xanthine uracil vitamin C permease BF25_RS23860 ENOG4108TYN CAAX amino terminal protease family protein BF25_RS23875 ENOG4105C5H ABC transporter BF25_RS23885 ENOG410801F ribosomal-protein-alanine acetyltransferase BF25_RS23890 ENOG41072GX Peptidase M22 Glycoprotease BF25_RS23895 ENOG4105K8N protein family UPF0079, ATPase BF25_RS23995 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BF25_RS24005 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF25_RS24010 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BF25_RS24020 ENOG4107ZXI Rhomboid family BF25_RS24035 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF25_RS24050 ENOG4108SC4 )-transporter BF25_RS24060 ENOG4105ERH Fumarylacetoacetate hydrolase BF25_RS24065 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BF25_RS24090 ENOG4108JQ7 (ABC) transporter BF25_RS24095 ENOG4105C3U ABC transporter BF25_RS24100 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF25_RS24110 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BF25_RS24125 ENOG4105C5H ABC transporter BF25_RS24150 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BF25_RS24155 ENOG4108RE7 deoxyribonuclease BF25_RS24170 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF25_RS24190 ENOG4105F6E Acyl-transferase BF25_RS24205 ENOG4105EGI Transcriptional regulator BF25_RS24220 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BF25_RS24235 ENOG4105E0C molybdate abc transporter BF25_RS24245 ENOG4107XDY Nicotinamide Mononucleotide Transporter BF25_RS24255 ENOG4105II7 pyrroline-5-carboxylate reductase BF25_RS24265 ENOG4108J59 Extracellular solute-binding protein, family 5 BF25_RS24270 ENOG4108J59 Extracellular solute-binding protein, family 5 BF25_RS24300 ENOG4108JQ7 (ABC) transporter BF25_RS24305 ENOG4105C3U ABC transporter BF25_RS24310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF25_RS24315 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF25_RS24330 ENOG4105C2C drug resistance transporter, Bcr CflA BF25_RS24345 ENOG4105IQ5 FAD linked oxidase domain protein BF25_RS24360 ENOG4105D01 (LipO)protein BF25_RS24365 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF25_RS24370 ENOG4108UMI ABC transporter, permease BF25_RS24410 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BF25_RS24415 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BF25_RS24435 ENOG4108VQT Alpha beta hydrolase fold protein BF25_RS24440 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BF25_RS24455 ENOG4107U5W ybbr family BF25_RS24460 ENOG4105C8B TIGR00159 family BF25_RS24545 ENOG4108NMV polysaccharide deacetylase BF25_RS24560 ENOG4105D1F ATP-binding protein BF25_RS24590 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF25_RS24635 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF25_RS24645 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF25_RS24775 ENOG4105XPM ribosomal protein BF25_RS24780 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BF25_RS24790 ENOG4107Y49 methyltransferase BF25_RS24815 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BF25_RS24830 ENOG4105QIV RNA polymerase BF25_RS24835 ENOG4105M0M Tetracycline resistance protein BF25_RS24840 ENOG4105C2N RNA methyltransferase TrmH family group 3 BF25_RS24855 ENOG4105D7W serine acetyltransferase BF25_RS24875 ENOG4105CTP PilT protein domain protein BF25_RS24885 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BF25_RS24900 ENOG4108Z0C Uvrb UvrC protein BF25_RS24930 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BF25_RS24940 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BF25_RS24945 ENOG4105KRF dihydroneopterin aldolase BF25_RS24950 ENOG4105EEI dihydropteroate synthase BF25_RS24955 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BF25_RS24960 ENOG4105DDQ anthranilate synthase BF25_RS24965 ENOG4105CRQ synthase (Component I) BF25_RS24970 ENOG4105C6T cysteine synthase BF25_RS24985 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BF25_RS24990 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF25_RS24995 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BF25_RS25015 ENOG41060GV RNA binding s1 domain protein BF25_RS25030 ENOG4105VYY sporulation protein yabp BF25_RS25035 ENOG41082I2 s4 domain protein BF25_RS25040 ENOG4108IY2 MazG family BF25_RS25050 ENOG4108M14 stage v sporulation protein t BF25_RS25055 ENOG4108JA2 transcriptioN-repair coupling factor BF25_RS25085 ENOG4105KME endoribonuclease L-psp BF25_RS25090 ENOG4105DFT pur operon repressor BF25_RS25105 ENOG4105W42 Veg protein BF25_RS25110 ENOG4105XFA sporulation peptidase YabG BF25_RS25120 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BF25_RS25125 ENOG4105F8V Hydrolase, tatD family BF25_RS25135 ENOG4105KRN Transcriptional regulator, abrb family BF25_RS25140 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BF25_RS25150 ENOG41060K3 Methyltransferase BF25_RS25160 ENOG4105MA4 psp1 domain protein BF25_RS25165 ENOG4105FA2 dna polymerase iii BF25_RS25175 ENOG4105CXN decarboxylase BF25_RS25210 ENOG41067KS pro-sigma K processing BF25_RS25230 ENOG4105C6E dna polymerase iii BF25_RS25235 ENOG4108Z6B deaminase BF25_RS25245 ENOG4105GTG Isochorismatase BF25_RS25255 ENOG4105ZMH deoxynucleoside kinase BF25_RS25290 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BF25_RS25325 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF25_RS25340 ENOG410848D S4 domain protein YaaA BF25_RS25345 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF25_RS25365 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF25_RS25395 ENOG4107QJE Chromosome Partitioning Protein BF25_RS25400 ENOG4105FA0 parb-like partition protein BF25_RS25405 ENOG4108ZDA Sporulation protein YyaC BF25_RS25410 ENOG4105D8X mechanosensitive ion channel BF25_RS25415 ENOG4105VDK protein, conserved in bacteria BF25_RS25420 ENOG4105C3G gtp-binding protein BF25_RS25430 ENOG4108UUM single-stranded DNA-binding protein BF25_RS25440 ENOG4108XMW Membrane BF25_RS25445 ENOG4105BZR domain protein BF25_RS25455 ENOG4105CDU Replicative dna helicase BF25_RS25485 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_RS25490 ENOG4105BZU Histidine kinase BF25_RS25505 ENOG4105Q2H domain protein BF25_RS25510 ENOG4105C0H protease BF25_RS25530 ENOG4105DPN Oligoendopeptidase f BF25_RS25545 ENOG4105C1J atp-dependent rna helicase BF25_RS25555 ENOG4108UT2 hemolysin iii BF25_RS25560 ENOG4105CMR udp-glucose 4-epimerase BF25_RS25570 ENOG4105IW1 AmiS UreI transporter BF25_RS25580 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF25_RS25595 ENOG4107RGD Major Facilitator superfamily BF25_RS25600 ENOG4108HRK Histidine kinase BF25_RS25605 ENOG4105DY9 regulatoR BF25_RS25620 ENOG4106F5Q Membrane BF25_RS25625 ENOG4105E0X reductase BF25_RS25635 ENOG41067SE Tetr family transcriptional regulator BF25_RS25640 ENOG4105CKK Glycosyl transferase, family 2 BF25_RS25665 ENOG4105C5H ABC transporter BF25_RS25670 ENOG4105JEU Glycosyl transferase, family 2 BF25_RS25680 ENOG4108S4H thioesterase Superfamily protein BF25_RS25690 ENOG4106YBV Methyl-accepting chemotaxis BF25_RS25695 ENOG4105EN6 Membrane BF25_RS25715 ENOG41079KZ Major Facilitator Superfamily BF25_RS25720 ENOG4105DY9 regulatoR BF25_RS25725 ENOG4105D22 carbon starvation protein BF25_RS25730 ENOG4105VCD cytoplasmic protein BF25_RS25735 ENOG4105BZU Histidine kinase BF25_RS25740 ENOG4105DWF phosphomethylpyrimidine kinase BF25_RS25750 ENOG4105WH1 Two component transcriptional regulator luxr family BF25_RS25760 ENOG4108Y4K DNA-binding transcriptional activator BF25_RS25785 ENOG4105D6E homoserine dehydrogenase BF25_RS25800 ENOG41090WU lipolytic protein G-D-S-L family BF25_RS25805 ENOG4105CJ1 ABC, transporter BF25_RS25810 ENOG4108TU7 Inherit from COG: (ABC) transporter BF25_RS25820 ENOG4105VCH membrane BF25_RS25825 ENOG410667J hydrolase BF25_RS25855 ENOG4108VKI Cell wall hydrolase BF25_RS25870 ENOG4108IJ2 phosphate acetyltransferase BF25_RS25885 ENOG4108VCI transcription factor, rsfa family BF25_RS25905 ENOG4105EHG Permease protein BF25_RS25910 ENOG4105E0A ABC, transporter BF25_RS25915 ENOG4108MES Periplasmic binding protein BF25_RS25920 ENOG4105DCI Phosphohydrolase BF25_RS25925 ENOG41069HH 4-oxalocrotonate tautomerase BF25_RS25930 ENOG4108Z4T Peptidase M50 BF25_RS25935 ENOG4108XFG YwhD family BF25_RS25940 ENOG4105BZ4 penicillin-binding protein BF25_RS25945 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF25_RS25950 ENOG4107SWG transcriptional regulator MERR family BF25_RS25955 ENOG4105DXB Major Facilitator superfamily BF25_RS25965 ENOG4105CYW agmatinase BF25_RS25990 ENOG410684U Domain of unknown function (DUF1934) BF25_RS26000 ENOG4105EMN RNA polymerase sigma factor BF25_RS26020 ENOG4105IIU Aminopeptidase BF25_RS26040 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BF25_RS26045 ENOG4108M15 ABC transporter BF25_RS26050 ENOG4105KCT ABC transporter BF25_RS26055 ENOG4105BZU Histidine kinase BF25_RS26075 ENOG4105BZU Histidine kinase BF25_RS26090 ENOG4105DF6 Fe-S oxidoreductase BF25_RS26100 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BF25_RS26105 ENOG4105C1G acyl-Coa dehydrogenase BF25_RS26110 ENOG4105C1G acyl-Coa dehydrogenase BF25_RS26150 ENOG4105CBT Fructose-1,6-bisphosphatase BF25_RS26155 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BF25_RS26175 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BF25_RS26180 ENOG4108ZXQ stage ii sporulation protein r BF25_RS26190 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF25_RS26205 ENOG4107XC4 flavin reductase domain protein, FMN-binding BF25_RS26210 ENOG4108VGI doxx family BF25_RS26225 ENOG4108YZG isomerase BF25_RS26255 ENOG41062M3 atp synthase BF25_RS26260 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BF25_RS26310 ENOG4105BZU Histidine kinase BF25_RS26325 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF25_RS26330 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF25_RS26355 ENOG4105D65 subunit l BF25_RS26360 ENOG4105C8S subunit m BF25_RS26365 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF25_RS26370 ENOG4106778 Protein of unknown function (DUF1146) BF25_RS26390 ENOG4108IUW ABC transporter BF25_RS26395 ENOG4105DY9 regulatoR BF25_RS26410 ENOG4105FRN stage II sporulation protein BF25_RS26425 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BF25_RS26480 ENOG4105EY8 ABC transporter BF25_RS26485 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF25_RS26500 ENOG4105CMR udp-glucose 4-epimerase BF25_RS26505 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_RS26510 ENOG4105BZU Histidine kinase BF25_RS26525 ENOG4105CXY transporter BF25_RS26545 ENOG4105C19 ABC transporter BF25_RS26550 ENOG4107RBB ABC transporter, permease BF25_RS26560 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF25_RS26590 ENOG4105C0D helicase BF25_RS26595 ENOG4105KBK Zinc finger, swim domain protein BF25_RS26620 ENOG41069ER domain protein BF25_RS26625 ENOG4105C94 Transporter BF25_RS26660 ENOG4105E0M Sulfatase BF25_RS26670 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BF25_RS26680 ENOG4105DAA L-lactate BF25_RS26725 ENOG4107RSM transcriptional regulator BF25_RS26730 ENOG4105ECB domain protein BF25_RS26735 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BF25_RS26750 ENOG4105VZJ PTS System BF25_RS26760 ENOG4105VCP PTS System BF25_RS26765 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF25_RS26770 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BF25_RS26780 ENOG4105CK1 PTS System BF25_RS26785 ENOG4105VCP PTS System BF25_RS26790 ENOG4105F8D glycoside hydrolase family 4 BF25_RS26795 ENOG410901P UPF0249 protein BF25_RS26810 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BF25_RS26820 ENOG4105ESV Glycosyl transferase, family 4 BF25_RS26825 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF25_RS26830 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF25_RS26835 ENOG4108KGH TRANSCRIPTIONal BF25_RS26840 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BF25_RS26855 ENOG4105KVH Transcriptional regulator BF25_RS26870 ENOG41081UC Inherit from COG: Competence protein BF25_RS26875 ENOG4105VEQ Cold shock protein BF25_RS26880 ENOG4105MS2 ribosomal subunit Interface protein BF25_RS26885 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BF25_RS26905 ENOG4105CAK Cell division ATP-binding protein ftsE BF25_RS26910 ENOG4105CRP Part of the ABC transporter FtsEX involved in BF25_RS26915 ENOG4105CN1 protease BF25_RS26925 ENOG4105BZ1 (ABC) transporter BF25_RS26940 ENOG4108WS4 fmn reductase BF25_RS26950 ENOG4105DUM transcriptional regulator, lysR family BF25_RS26955 ENOG4105HMI Membrane BF25_RS26980 ENOG4107TXC Transcriptional regulator BF25_RS26995 ENOG4105D7V transposase BF25_RS27000 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BF25_RS27005 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF25_RS27015 ENOG41086DT Membrane protein of unknown function BF25_RS27035 ENOG4108S4C acetyltransferase BF25_RS27045 ENOG4105C3M thioredoxin reductase BF25_RS27055 ENOG4108Z4K mutator MutT protein BF25_RS27065 ENOG4105CHW UPF0052 protein BF25_RS27075 ENOG4105KRI phosphocarrier protein (HPr BF25_RS27080 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF25_RS27085 ENOG4105H67 Protein of unknown function (DUF421) BF25_RS27100 ENOG4105CZ3 stage V sporulation protein ad BF25_RS27105 ENOG41090VF Stage v sporulation protein ac BF25_RS27125 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF25_RS27150 ENOG4105CP7 Triose-phosphate isomerase BF25_RS27155 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BF25_RS27165 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF25_RS27190 ENOG4105EFC phage portal protein HK97 family BF25_RS27290 ENOG41067MG lrgb family BF25_RS27295 ENOG4105XZU Preprotein translocase, subunit SecG BF25_RS27305 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BF25_RS27315 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_RS27330 ENOG4105CM4 permease protein BF25_RS27335 ENOG4108IPW abc transporter atp-binding protein BF25_RS27355 ENOG4108MK9 spermidine N(1)-acetyltransferase BF25_RS27370 ENOG4105WMR Protein CrcB homolog BF25_RS27375 ENOG4105WMR Protein CrcB homolog BF25_RS27385 ENOG4105C8Q Methyl-accepting chemotaxis BF25_RS27395 ENOG4105D4A Cell wall formation (By similarity) BF25_RS27400 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF25_RS27415 ENOG4105KVH Transcriptional regulator BF25_RS27420 ENOG4105F27 Major Facilitator BF25_RS27425 ENOG4105CV8 reductase BF25_RS27440 ENOG4108RYK Nad-dependent epimerase dehydratase BF25_RS27455 ENOG4105D9N nucleoside BF25_RS27460 ENOG4105D9N nucleoside BF25_RS27485 ENOG4108URH decarboxylase BF25_RS27500 ENOG4108RMU ferritin dps family protein BF25_RS27515 ENOG4105NCW Trka-c domain protein BF25_RS27520 ENOG4107S91 Sodium hydrogen exchanger BF25_RS27540 ENOG4105D4Y metalloprotease BF25_RS27545 ENOG4105VG1 fes assembly suf system protein BF25_RS27570 ENOG4105BZU Histidine kinase BF25_RS27575 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_RS27580 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BF25_RS27590 ENOG4107ZTW SNARE associated Golgi BF25_RS27625 ENOG4107AYK membrAne BF25_RS27635 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF25_RS27645 ENOG4107R7I amino acid BF25_RS27650 ENOG4108SUT Major Facilitator Superfamily BF25_RS27670 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF25_RS27690 ENOG4105DZ1 carboxypeptidase BF25_RS27705 ENOG4105CHU acetyl-coa acetyltransferase BF25_RS27715 ENOG4105C1G acyl-Coa dehydrogenase BF25_RS27720 ENOG4108W8B Beta-lactamase domain protein BF25_RS27750 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF25_RS27800 ENOG41080E8 Transcriptional regulator, Spx MgsR family BF25_RS27835 ENOG4108UMI ABC transporter, permease BF25_RS27840 ENOG4105D01 (LipO)protein BF25_RS27845 ENOG4105D01 (LipO)protein BF25_RS27850 ENOG4105C3K feS assembly ATPase SufC BF25_RS27855 ENOG4105JRK feS assembly protein SufD BF25_RS27860 ENOG4105C9B Cysteine desulfurase BF25_RS27865 ENOG4108UNV SUF system FeS assembly protein, NifU family BF25_RS27870 ENOG4105DIW FeS assembly protein SUFB BF25_RS27895 ENOG4107R8B 5'-nucleotidase BF25_RS27900 ENOG4105KZD Domain of unknown function (DUF1805) BF25_RS27910 ENOG4105FAA peptidase M23 BF25_RS27935 ENOG41090T1 Membrane BF25_RS27940 ENOG4107TXC Transcriptional regulator BF25_RS27945 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BF25_RS27950 ENOG4105MMD transcriptional regulator BF25_RS27970 ENOG4105CBT Fructose-1,6-bisphosphatase BF25_RS27985 ENOG4105D4U had-superfamily hydrolase, subfamily iia BF25_RS27990 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF25_RS28005 ENOG4108W5N phosphatidylglycerophosphatase a BF25_RS28020 ENOG41083MR nifu domain-containing protein BF25_RS28065 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BF25_RS28070 ENOG4105C4B ABC transporter, permease BF25_RS28075 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF25_RS28100 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BF25_RS28120 ENOG4105EWC Purine nucleoside phosphorylase BF25_RS28150 ENOG4105CEP NADH dehydrogenase BF25_RS28165 ENOG41069ER domain protein BF25_RS28185 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF25_RS28205 ENOG4105KA0 thioesterase Superfamily protein BF25_RS28225 ENOG4107R3E Citrate transporter BF25_RS28235 ENOG4105Y38 Kinase-associated protein B BF25_RS28250 ENOG4105C87 Aminotransferase class I and II BF25_RS28260 ENOG4108MUZ hydrolase BF25_RS28265 ENOG4105C5I Dehydrogenase BF25_RS28270 ENOG4108ZB6 transcriptional regulator AsnC family BF25_RS28275 ENOG4105CHM Aminotransferase BF25_RS28285 ENOG4105WG9 Conserved Protein BF25_RS28295 ENOG4107QYV phosphohexose isomerase BF25_RS28305 ENOG4107PBV potassium channel BF25_RS28310 ENOG4105KT7 mgtC SapB transporter BF25_RS28345 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BF25_RS28460 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BF25_RS28485 ENOG4105VEQ Cold shock protein BF25_RS28495 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF25_RS28500 ENOG4105E4F Isochorismate synthase BF25_RS28505 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BF25_RS28510 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BF25_RS28515 ENOG4108IPT Naphthoate synthase BF25_RS28525 ENOG4105DTQ mandelate racemase muconate lactonizing BF25_RS28555 ENOG41069H0 dihydroorotase EC 3.5.2.3 BF25_RS28580 ENOG4105C6Z Gluconate BF25_RS28630 ENOG41086D8 Transcriptional regulator BF25_RS28635 ENOG4105C19 ABC transporter BF25_RS28650 ENOG4107ZTW SNARE associated Golgi BF25_RS28685 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BF25_RS28690 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF25_RS28715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_RS28720 ENOG4105BZU Histidine kinase BF25_RS28755 ENOG41087YS Phage shock protein A BF25_RS28800 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF25_RS28805 ENOG4105C4M (Ubiquinol oxidase) subunit I BF25_RS28810 ENOG4108V2W Carbonate dehydratase BF25_RS28865 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BF25_RS28875 ENOG4105D2X ABC transporter substrate-binding protein BF25_RS28895 ENOG4107S9D Alpha beta hydrolase BF25_RS28900 ENOG4105BZU Histidine kinase BF25_RS28905 ENOG4105BZU Histidine kinase BF25_RS28910 ENOG4105EGD dinuclear metal center protein, YbgI family BF25_RS28965 ENOG4108RIR Molybdenum cofactor biosynthesis protein BF25_RS28975 ENOG4105BZF Glycosyl transferase (Group 1 BF25_RS28980 ENOG4105YVM Phosphoesterase, PA-phosphatase related BF25_RS28985 ENOG4108Z0R Transferase BF25_RS28990 ENOG4105E8V Alpha Beta Hydrolase Fold protein BF25_RS29020 ENOG4105DA5 (ABC) transporter BF25_RS29030 ENOG4105N5T Radical SAM Protein BF25_RS29050 ENOG4105C19 ABC transporter BF25_RS29065 ENOG4105NCW Trka-c domain protein BF25_RS29070 ENOG4107S91 Sodium hydrogen exchanger BF25_RS29075 ENOG410605W Major Facilitator BF25_RS29110 ENOG4108B31 Spore germination protein BF25_RS29120 ENOG4105DWV Homoserine O-trans-acetylase BF25_RS29130 ENOG41085GJ domain protein BF25_RS29155 ENOG4105D06 uba thif-type nad fad binding protein BF25_RS29165 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF25_RS29170 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BF25_RS29175 ENOG4108ZAF Molybdopterin BF25_RS29190 ENOG4105CSC Glucose uptake protein BF25_RS29195 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BF25_RS29200 ENOG4108VJ1 Transcriptional regulator (CarD family BF25_RS29235 ENOG4105CBX hi0933 family BF25_RS29250 ENOG4105YW5 deoR family transcriptional regulator BF25_RS29275 ENOG4108IUM Glycogen debranching enzyme BF25_RS29280 ENOG4108V15 phosphotransferase enzyme family BF25_RS29295 ENOG4105C8F Beta-lactamase domain protein BF25_RS30065 ENOG41090MY MarR family Transcriptional regulator BF25_RS30660 ENOG4105CBS Chea signal transduction histidine kinase BF25_RS30865 ENOG4105CMT Dihydroxyacetone kinase BF25_RS30890 ENOG4105PKS Excinuclease abc c subunit domain protein BF25_RS31650 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF25_RS31695 ENOG4105KRN Transcriptional regulator, abrb family BF25_RS31810 ENOG4105EYF MMPL domain protein