locus-tag	class	description
M1D19_RS00010	COG0592	DNA-directed DNA polymerase activity
M1D19_RS00015	COG2501	S4 domain
M1D19_RS00025	COG0187	DNA topoisomerase II activity
M1D19_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M1D19_RS00065	COG0516	GMP reductase activity
M1D19_RS00065	COG0517	IMP dehydrogenase activity
M1D19_RS00070	COG1686	Belongs to the peptidase S11 family
M1D19_RS00100	COG1428	Deoxynucleoside kinase
M1D19_RS00105	COG1428	Deoxynucleoside kinase
M1D19_RS00110	COG1335	isochorismatase
M1D19_RS00115	COG0590	tRNA wobble adenosine to inosine editing
M1D19_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1D19_RS00180	COG1982	Orn Lys Arg decarboxylase major
M1D19_RS00190	COG0470	DNA polymerase III
M1D19_RS00195	COG1774	PSP1 C-terminal conserved region
M1D19_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M1D19_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M1D19_RS00220	COG2002	toxin-antitoxin pair type II binding
M1D19_RS00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1D19_RS00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1D19_RS00230	COG0084	hydrolase, TatD family'
M1D19_RS00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M1D19_RS00250	COG4466	Protein conserved in bacteria
M1D19_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M1D19_RS00270	COG0251	oxidation-reduction process
M1D19_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1D19_RS00305	COG2002	toxin-antitoxin pair type II binding
M1D19_RS00310	COG2244	polysaccharide biosynthetic process
M1D19_RS00315	COG3956	TIGRFAM MazG family protein
M1D19_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1D19_RS00340	COG1098	S1 RNA binding domain
M1D19_RS00355	COG2208	phosphoserine phosphatase activity
M1D19_RS00360	COG0037	tRNA processing
M1D19_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M1D19_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1D19_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1D19_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1D19_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
M1D19_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1D19_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1D19_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M1D19_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1D19_RS00420	COG1396	sequence-specific DNA binding
M1D19_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1D19_RS00455	COG3880	PFAM UvrB UvrC protein
M1D19_RS00465	COG0542	response to heat
M1D19_RS00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M1D19_RS00480	COG4956	integral membrane protein (PIN domain superfamily)
M1D19_RS00500	COG1045	serine acetyltransferase
M1D19_RS00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1D19_RS00520	COG3688	RNA-binding protein containing a PIN domain
M1D19_RS00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M1D19_RS00540	COG0250	Participates in transcription elongation, termination and antitermination
M1D19_RS00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M1D19_RS00565	COG2813	Specifically methylates the guanine in position
M1D19_RS00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M1D19_RS00580	COG1358	cellular component organization or biogenesis
M1D19_RS00650	COG0255	Belongs to the universal ribosomal protein uL29 family
M1D19_RS00710	COG0201	protein transport
M1D19_RS00720	COG0024	Methionine aminopeptidase
M1D19_RS00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M1D19_RS00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M1D19_RS00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
M1D19_RS00795	COG0489	protein tyrosine kinase activity
M1D19_RS00805	COG2194	sulfuric ester hydrolase activity
M1D19_RS00810	COG0726	polysaccharide deacetylase
M1D19_RS00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M1D19_RS00895	COG4856	YbbR-like protein
M1D19_RS00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1D19_RS00915	COG0596	Alpha beta hydrolase
M1D19_RS00935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M1D19_RS00940	COG0823	Involved in the tonB-independent uptake of proteins
M1D19_RS00940	COG1506	peptidase
M1D19_RS00940	COG4946	Tricorn protease homolog
M1D19_RS00975	COG2011	ABC-type metal ion transport system permease component
M1D19_RS00980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1D19_RS00985	COG1464	Belongs to the NlpA lipoprotein family
M1D19_RS00990	COG0604	alcohol dehydrogenase
M1D19_RS01000	COG0277	FAD linked oxidase domain protein
M1D19_RS01005	COG2271	Major facilitator Superfamily
M1D19_RS01015	COG2814	Major facilitator Superfamily
M1D19_RS01030	COG0601	transmembrane transport
M1D19_RS01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1D19_RS01040	COG0444	Belongs to the ABC transporter superfamily
M1D19_RS01045	COG4608	Belongs to the ABC transporter superfamily
M1D19_RS01050	COG4166	transmembrane transport
M1D19_RS01060	COG2207	Transcriptional regulator
M1D19_RS01075	COG4166	transmembrane transport
M1D19_RS01080	COG4166	transmembrane transport
M1D19_RS01085	COG0656	L-ascorbic acid biosynthetic process
M1D19_RS01105	COG4149	molybdate abc transporter
M1D19_RS01115	COG1910	domain protein
M1D19_RS01125	COG0583	DNA-binding transcription factor activity
M1D19_RS01130	COG0697	spore germination
M1D19_RS01145	COG0204	Acyl-transferase
M1D19_RS01155	COG1609	Transcriptional regulator
M1D19_RS01165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1D19_RS01175	COG0084	hydrolase, TatD family'
M1D19_RS01180	COG5298	Protein conserved in bacteria
M1D19_RS01205	COG0488	(ABC) transporter
M1D19_RS01220	COG0747	negative chemotaxis
M1D19_RS01225	COG0601	transmembrane transport
M1D19_RS01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1D19_RS01235	COG0444	Belongs to the ABC transporter superfamily
M1D19_RS01260	COG3185	4-Hydroxyphenylpyruvate dioxygenase
M1D19_RS01265	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1D19_RS01275	COG2814	Major facilitator Superfamily
M1D19_RS01285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1D19_RS01295	COG4294	response to UV
M1D19_RS01300	COG0705	Rhomboid family
M1D19_RS01300	COG0457	Tetratricopeptide repeat
M1D19_RS01310	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1D19_RS01315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1D19_RS01320	COG0864	Transcriptional regulator
M1D19_RS01325	COG2337	Toxic component of a toxin-antitoxin (TA) module
M1D19_RS01330	COG2183	response to ionizing radiation
M1D19_RS01425	COG0802	atpase or kinase
M1D19_RS01430	COG1214	PFAM Peptidase M22, glycoprotease
M1D19_RS01435	COG0456	acetyltransferase
M1D19_RS01445	COG0488	(ABC) transporter
M1D19_RS01460	COG1266	CAAX protease self-immunity
M1D19_RS01480	COG2252	PERMEase
M1D19_RS01490	COG5002	protein histidine kinase activity
M1D19_RS01520	COG2226	methyltransferase
M1D19_RS01565	COG1968	undecaprenyl-diphosphatase activity
M1D19_RS01580	COG2205	protein histidine kinase activity
M1D19_RS01585	COG0745	RESPONSE REGULATOR receiver
M1D19_RS01610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M1D19_RS01615	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1D19_RS01620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1D19_RS01630	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1D19_RS01645	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M1D19_RS01655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1D19_RS01665	COG0151	Belongs to the GarS family
M1D19_RS01690	COG0210	DNA helicase
M1D19_RS01700	COG4851	CamS sex pheromone cAM373 precursor
M1D19_RS01720	COG1335	isochorismatase
M1D19_RS01725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1D19_RS01730	COG2011	ABC-type metal ion transport system permease component
M1D19_RS01735	COG1464	Belongs to the NlpA lipoprotein family
M1D19_RS01755	COG1846	Transcriptional regulator
M1D19_RS01780	COG1597	lipid kinase activity
M1D19_RS01785	COG0546	phosphoglycolate phosphatase activity
M1D19_RS01790	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1D19_RS01800	COG1012	belongs to the aldehyde dehydrogenase family
M1D19_RS01805	COG2076	Multidrug Resistance protein
M1D19_RS01810	COG2309	aminopeptidase activity
M1D19_RS01825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M1D19_RS01830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M1D19_RS01835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1D19_RS01845	COG4807	Protein conserved in bacteria
M1D19_RS01870	COG1757	Na H antiporter
M1D19_RS01875	COG1473	amidohydrolase
M1D19_RS01890	COG0450	alkyl hydroperoxide reductase
M1D19_RS01910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1D19_RS01915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1D19_RS01920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1D19_RS01935	COG0166	Belongs to the GPI family
M1D19_RS01970	COG5002	protein histidine kinase activity
M1D19_RS01990	COG3541	Predicted nucleotidyltransferase
M1D19_RS01995	COG2814	Major facilitator Superfamily
M1D19_RS02000	COG0723	plastoquinol--plastocyanin reductase activity
M1D19_RS02000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1D19_RS02010	COG0765	amino acid transport
M1D19_RS02015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1D19_RS02025	COG0840	transmembrane signaling receptor activity
M1D19_RS02030	COG0840	transmembrane signaling receptor activity
M1D19_RS02035	COG0366	Alpha amylase catalytic
M1D19_RS02040	COG2190	(PTS) system
M1D19_RS02040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1D19_RS02040	COG1263	PTS System
M1D19_RS02070	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M1D19_RS02085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1D19_RS02095	COG1116	anion transmembrane transporter activity
M1D19_RS02100	COG0488	(ABC) transporter
M1D19_RS02145	COG2270	Major facilitator Superfamily
M1D19_RS02160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M1D19_RS02175	COG2310	stress, protein
M1D19_RS02180	COG2310	stress, protein
M1D19_RS02185	COG2310	stress, protein
M1D19_RS02190	COG0861	Integral membrane protein TerC family
M1D19_RS02200	COG3853	Toxic anion resistance protein (TelA)
M1D19_RS02215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1D19_RS02225	COG1295	ribonuclease BN
M1D19_RS02230	COG2217	Heavy metal translocating P-type atpase
M1D19_RS02235	COG0697	spore germination
M1D19_RS02255	COG0586	Pfam SNARE associated Golgi protein
M1D19_RS02270	COG3871	stress protein (general stress protein 26)
M1D19_RS02275	COG0387	Pfam Sodium calcium exchanger
M1D19_RS02285	COG0535	radical SAM domain protein
M1D19_RS02310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M1D19_RS02315	COG0582	viral genome integration into host DNA
M1D19_RS02325	COG1396	sequence-specific DNA binding
M1D19_RS02345	COG1396	sequence-specific DNA binding
M1D19_RS02380	COG1484	DNA-dependent DNA replication
M1D19_RS02610	COG0101	tRNA pseudouridine synthase activity
M1D19_RS02620	COG3829	transcription factor binding
M1D19_RS02630	COG0833	amino acid
M1D19_RS02635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1D19_RS02665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1D19_RS02665	COG1263	PTS System
M1D19_RS02670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1D19_RS02685	COG0463	Glycosyl transferase, family 2
M1D19_RS02700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M1D19_RS02700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1D19_RS02715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M1D19_RS02735	COG1228	amidohydrolase
M1D19_RS02740	COG1090	epimerase
M1D19_RS02770	COG1988	membrane-bound metal-dependent
M1D19_RS02775	COG1194	a g-specific adenine glycosylase
M1D19_RS02800	COG1132	(ABC) transporter
M1D19_RS02805	COG4129	membrane
M1D19_RS02810	COG0067	glutamate synthase
M1D19_RS02810	COG0069	glutamate synthase activity
M1D19_RS02810	COG0070	glutamate synthase
M1D19_RS02820	COG4555	ABC transporter
M1D19_RS02840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1D19_RS02845	COG0735	belongs to the Fur family
M1D19_RS02960	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M1D19_RS02965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1D19_RS02975	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1D19_RS02985	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1D19_RS02995	COG2766	serine protein kinase
M1D19_RS03015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1D19_RS03025	COG1585	Membrane protein implicated in regulation of membrane protease activity
M1D19_RS03030	COG2268	Band 7 protein
M1D19_RS03040	COG3290	protein histidine kinase activity
M1D19_RS03050	COG2851	Citrate transporter
M1D19_RS03070	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M1D19_RS03075	COG3842	ATPase activity
M1D19_RS03080	COG1175	transmembrane transport
M1D19_RS03085	COG0395	ABC-type sugar transport system, permease component
M1D19_RS03095	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1D19_RS03100	COG0745	RESPONSE REGULATOR receiver
M1D19_RS03105	COG5002	protein histidine kinase activity
M1D19_RS03115	COG4990	cell redox homeostasis
M1D19_RS03125	COG3290	protein histidine kinase activity
M1D19_RS03130	COG4565	transcriptional regulatory protein
M1D19_RS03135	COG3493	citrate carrier protein
M1D19_RS03140	COG0281	malic enzyme
M1D19_RS03155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1D19_RS03165	COG5002	protein histidine kinase activity
M1D19_RS03170	COG0745	RESPONSE REGULATOR receiver
M1D19_RS03180	COG0454	-acetyltransferase
M1D19_RS03180	COG0456	acetyltransferase
M1D19_RS03185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1D19_RS03190	COG3383	formate dehydrogenase (NAD+) activity
M1D19_RS03210	COG0531	amino acid
M1D19_RS03215	COG0640	Transcriptional regulator
M1D19_RS03220	COG2217	Heavy metal translocating P-type atpase
M1D19_RS03225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M1D19_RS03240	COG3227	Zinc metalloprotease (Elastase)
M1D19_RS03260	COG2720	vancomycin resistance protein
M1D19_RS03265	COG1316	TRANSCRIPTIONal
M1D19_RS03270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M1D19_RS03275	COG0346	lactoylglutathione lyase activity
M1D19_RS03285	COG1027	Aspartate ammonia-lyase
M1D19_RS03290	COG1620	l-lactate permease
M1D19_RS03305	COG3104	oligopeptide transport
M1D19_RS03310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1D19_RS03315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1D19_RS03320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1D19_RS03330	COG2226	methyltransferase
M1D19_RS03335	COG0156	8-amino-7-oxononanoate synthase activity
M1D19_RS03350	COG4548	von Willebrand factor, type A
M1D19_RS03355	COG0714	Associated with various cellular activities
M1D19_RS03360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1D19_RS03380	COG0531	amino acid
M1D19_RS03385	COG2188	Transcriptional regulator
M1D19_RS03390	COG1263	PTS System
M1D19_RS03390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1D19_RS03395	COG0366	Alpha amylase catalytic
M1D19_RS03410	COG0697	spore germination
M1D19_RS03420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1D19_RS03425	COG1115	amino acid carrier protein
M1D19_RS03430	COG1126	abc transporter atp-binding protein
M1D19_RS03435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1D19_RS03440	COG0765	amino acid transport
M1D19_RS03445	COG0765	amino acid transport
M1D19_RS03450	COG0833	amino acid
M1D19_RS03475	COG2378	regulation of single-species biofilm formation
M1D19_RS03480	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1D19_RS03485	COG5002	protein histidine kinase activity
M1D19_RS03500	COG0659	secondary active sulfate transmembrane transporter activity
M1D19_RS03515	COG0747	negative chemotaxis
M1D19_RS03525	COG0601	transmembrane transport
M1D19_RS03530	COG4608	Belongs to the ABC transporter superfamily
M1D19_RS03540	COG2271	Major facilitator Superfamily
M1D19_RS03545	COG1846	Transcriptional regulator
M1D19_RS03555	COG1609	Transcriptional regulator
M1D19_RS03560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1D19_RS03575	COG1172	Belongs to the binding-protein-dependent transport system permease family
M1D19_RS03580	COG1879	ABC-type sugar transport system periplasmic component
M1D19_RS03605	COG1063	alcohol dehydrogenase
M1D19_RS03620	COG3568	Endonuclease Exonuclease Phosphatase
M1D19_RS03645	COG1968	undecaprenyl-diphosphatase activity
M1D19_RS03650	COG0840	transmembrane signaling receptor activity
M1D19_RS03655	COG1388	LysM domain
M1D19_RS03655	COG3584	3D domain protein
M1D19_RS03660	COG1476	TRANSCRIPTIONal
M1D19_RS03675	COG3104	oligopeptide transport
M1D19_RS03680	COG1114	Component of the transport system for branched-chain amino acids
M1D19_RS03695	COG1113	amino acid transport
M1D19_RS03700	COG2252	PERMEase
M1D19_RS03725	COG0475	glutathione-regulated potassium exporter activity
M1D19_RS03725	COG0569	domain protein
M1D19_RS03740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1D19_RS03745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1D19_RS03750	COG4990	cell redox homeostasis
M1D19_RS03765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1D19_RS03770	COG0697	spore germination
M1D19_RS03775	COG0531	amino acid
M1D19_RS03785	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M1D19_RS03790	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M1D19_RS03795	COG1918	ferrous iron import across plasma membrane
M1D19_RS03795	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M1D19_RS03800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1D19_RS03805	COG0573	inorganic phosphate transmembrane transporter activity
M1D19_RS03810	COG0581	inorganic phosphate transmembrane transporter activity
M1D19_RS03820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1D19_RS03935	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M1D19_RS03955	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1D19_RS03960	COG1116	anion transmembrane transporter activity
M1D19_RS03965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1D19_RS03970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1D19_RS03975	COG0352	thiamine-phosphate diphosphorylase activity
M1D19_RS03980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1D19_RS03985	COG2104	thiamine diphosphate biosynthetic process
M1D19_RS03995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M1D19_RS04000	COG0351	phosphomethylpyrimidine kinase
M1D19_RS04040	COG2205	protein histidine kinase activity
M1D19_RS04045	COG2814	Major facilitator Superfamily
M1D19_RS04050	COG1846	Transcriptional regulator
M1D19_RS04065	COG2252	PERMEase
M1D19_RS04070	COG1028	Short-chain dehydrogenase reductase Sdr
M1D19_RS04085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1D19_RS04090	COG1621	beta-fructofuranosidase activity
M1D19_RS04095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1D19_RS04095	COG1263	PTS System
M1D19_RS04100	COG1609	Transcriptional regulator
M1D19_RS04110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1D19_RS04115	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M1D19_RS04150	COG0778	Nitroreductase
M1D19_RS04155	COG2719	SpoVR family
M1D19_RS04180	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1D19_RS04185	COG1937	Protein conserved in bacteria
M1D19_RS04190	COG0425	Belongs to the sulfur carrier protein TusA family
M1D19_RS04190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M1D19_RS04195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1D19_RS04195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M1D19_RS04200	COG0425	Belongs to the sulfur carrier protein TusA family
M1D19_RS04215	COG2210	Belongs to the sulfur carrier protein TusA family
M1D19_RS04220	COG0730	response to heat
M1D19_RS04230	COG1316	TRANSCRIPTIONal
M1D19_RS04235	COG0604	alcohol dehydrogenase
M1D19_RS04240	COG1283	sodium-dependent phosphate transmembrane transporter activity
M1D19_RS04255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1D19_RS04255	COG3711	transcriptional antiterminator
M1D19_RS04260	COG1447	Phosphotransferase system cellobiose-specific component IIA
M1D19_RS04265	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M1D19_RS04285	COG3584	3D domain protein
M1D19_RS04285	COG1388	LysM domain
M1D19_RS04290	COG0577	efflux transmembrane transporter activity
M1D19_RS04295	COG1136	(ABC) transporter
M1D19_RS04305	COG5522	Integral membrane protein (intg_mem_TP0381)
M1D19_RS04320	COG1114	Component of the transport system for branched-chain amino acids
M1D19_RS04325	COG3546	catalase activity
M1D19_RS04360	COG0586	Pfam SNARE associated Golgi protein
M1D19_RS04395	COG0531	amino acid
M1D19_RS04400	COG0475	glutathione-regulated potassium exporter activity
M1D19_RS04410	COG1737	Transcriptional regulator
M1D19_RS04420	COG1263	PTS System
M1D19_RS04420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1D19_RS04430	COG2259	Doxx family
M1D19_RS04445	COG0697	spore germination
M1D19_RS04450	COG1522	sequence-specific DNA binding
M1D19_RS04465	COG2076	Multidrug Resistance protein
M1D19_RS04470	COG1309	transcriptional regulator
M1D19_RS04475	COG2814	Major facilitator Superfamily
M1D19_RS04480	COG1733	regulation of RNA biosynthetic process
M1D19_RS04490	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1D19_RS04495	COG4533	DNA binding
M1D19_RS04500	COG2211	Major facilitator Superfamily
M1D19_RS04510	COG0693	protein deglycase activity
M1D19_RS04515	COG0753	catalase activity
M1D19_RS04525	COG0531	amino acid
M1D19_RS04530	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1D19_RS04540	COG1012	belongs to the aldehyde dehydrogenase family
M1D19_RS04545	COG1132	(ABC) transporter
M1D19_RS04555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1D19_RS04560	COG0765	amino acid transport
M1D19_RS04565	COG1126	abc transporter atp-binding protein
M1D19_RS04580	COG0189	ligase activity
M1D19_RS04610	COG0028	Belongs to the TPP enzyme family
M1D19_RS04615	COG3527	Alpha-acetolactate decarboxylase
M1D19_RS04630	COG0561	phosphatase activity
M1D19_RS04645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1D19_RS04660	COG0659	secondary active sulfate transmembrane transporter activity
M1D19_RS04680	COG0653	protein targeting
M1D19_RS04685	COG2244	polysaccharide biosynthetic process
M1D19_RS04695	COG0860	N-Acetylmuramoyl-L-alanine amidase
M1D19_RS04700	COG4196	transglutaminase domain protein
M1D19_RS04715	COG1696	Membrane protein involved in D-alanine export
M1D19_RS04730	COG1024	Enoyl-CoA hydratase
M1D19_RS04750	COG1363	Peptidase, m42
M1D19_RS04770	COG3938	Belongs to the proline racemase family
M1D19_RS04810	COG0601	transmembrane transport
M1D19_RS04815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1D19_RS04825	COG4608	Belongs to the ABC transporter superfamily
M1D19_RS04860	COG0477	Major facilitator Superfamily
M1D19_RS04865	COG3290	protein histidine kinase activity
M1D19_RS04870	COG4565	transcriptional regulatory protein
M1D19_RS04875	COG3181	Tripartite tricarboxylate transporter family receptor
M1D19_RS04905	COG0789	Transcriptional regulator
M1D19_RS04905	COG4978	Transcriptional regulator
M1D19_RS04920	COG0305	Participates in initiation and elongation during chromosome replication
M1D19_RS04960	COG0477	Major facilitator Superfamily
M1D19_RS05005	COG3320	Male sterility
M1D19_RS05005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1D19_RS05010	COG1309	transcriptional regulator
M1D19_RS05030	COG1183	phosphatidylcholine synthase activity
M1D19_RS05050	COG2376	Dihydroxyacetone kinase
M1D19_RS05060	COG2376	Dihydroxyacetone kinase
M1D19_RS05065	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1D19_RS05070	COG1959	2 iron, 2 sulfur cluster binding
M1D19_RS05100	COG2770	Histidine kinase
M1D19_RS05100	COG3437	response regulator, receiver
M1D19_RS05155	COG3237	CsbD-like
M1D19_RS05180	COG1191	sigma factor activity
M1D19_RS05190	COG2208	phosphoserine phosphatase activity
M1D19_RS05195	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M1D19_RS05200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1D19_RS05200	COG2198	Histidine kinase
M1D19_RS05200	COG2205	protein histidine kinase activity
M1D19_RS05200	COG0784	Response regulator, receiver
M1D19_RS05255	COG0420	3'-5' exonuclease activity
M1D19_RS05280	COG1309	transcriptional regulator
M1D19_RS05285	COG2814	Major facilitator Superfamily
M1D19_RS05290	COG0346	lactoylglutathione lyase activity
M1D19_RS05295	COG0346	lactoylglutathione lyase activity
M1D19_RS05300	COG0457	Tetratricopeptide repeat
M1D19_RS05310	COG2267	carboxylic ester hydrolase activity
M1D19_RS05330	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M1D19_RS05335	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M1D19_RS05345	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M1D19_RS05385	COG0477	Major facilitator Superfamily
M1D19_RS05390	COG0477	Major facilitator Superfamily
M1D19_RS05400	COG3973	AAA domain
M1D19_RS05405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1D19_RS05425	COG4980	gas vesicle protein
M1D19_RS05430	COG0537	adenosine 5'-monophosphoramidase activity
M1D19_RS05435	COG1131	(ABC) transporter
M1D19_RS05440	COG4473	ABC transporter
M1D19_RS05455	COG1309	transcriptional regulator
M1D19_RS05465	COG3402	PFAM membrane-flanked domain
M1D19_RS05510	COG3402	PFAM membrane-flanked domain
M1D19_RS05515	COG3428	Bacterial PH domain
M1D19_RS05520	COG2329	Antibiotic biosynthesis monooxygenase
M1D19_RS05525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1D19_RS05530	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M1D19_RS05535	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M1D19_RS05540	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M1D19_RS05575	COG1309	transcriptional regulator
M1D19_RS05580	COG1511	domain protein
M1D19_RS05615	COG1234	tRNA 3'-trailer cleavage
M1D19_RS05620	COG0095	Lipoate-protein ligase
M1D19_RS05630	COG0318	PFAM AMP-dependent synthetase and ligase
M1D19_RS05660	COG3209	COG3209 Rhs family protein
M1D19_RS05700	COG1078	dGTPase activity
M1D19_RS05710	COG1595	DNA-templated transcription, initiation
M1D19_RS05715	COG2207	Transcriptional regulator
M1D19_RS05715	COG3708	Transcriptional regulator
M1D19_RS05730	COG2205	protein histidine kinase activity
M1D19_RS05735	COG0745	RESPONSE REGULATOR receiver
M1D19_RS05760	COG0501	Belongs to the peptidase M48B family
M1D19_RS05765	COG0840	transmembrane signaling receptor activity
M1D19_RS05770	COG0697	spore germination
M1D19_RS05790	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1D19_RS05795	COG2224	Isocitrate lyase
M1D19_RS05820	COG4903	ComK protein
M1D19_RS05825	COG0398	Pfam SNARE associated Golgi protein
M1D19_RS05835	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
M1D19_RS05840	COG1074	ATP-dependent DNA helicase activity
M1D19_RS05885	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1D19_RS05910	COG0367	asparagine synthase
M1D19_RS05915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M1D19_RS05920	COG0753	catalase activity
M1D19_RS05925	COG0004	ammonium transporteR
M1D19_RS05945	COG2996	Protein conserved in bacteria
M1D19_RS05955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1D19_RS05965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1D19_RS05980	COG0561	phosphatase activity
M1D19_RS05990	COG0542	response to heat
M1D19_RS06000	COG2267	carboxylic ester hydrolase activity
M1D19_RS06015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M1D19_RS06020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1D19_RS06025	COG5504	Zn-dependent protease
M1D19_RS06035	COG0180	Tryptophanyl-tRNA synthetase
M1D19_RS06045	COG4166	transmembrane transport
M1D19_RS06050	COG0601	transmembrane transport
M1D19_RS06055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1D19_RS06060	COG0444	Belongs to the ABC transporter superfamily
M1D19_RS06065	COG4608	Belongs to the ABC transporter superfamily
M1D19_RS06070	COG0534	Mate efflux family protein
M1D19_RS06075	COG4166	transmembrane transport
M1D19_RS06090	COG0861	Integral membrane protein TerC family
M1D19_RS06095	COG4862	establishment of competence for transformation
M1D19_RS06100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1D19_RS06110	COG1164	Oligoendopeptidase f
M1D19_RS06120	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1D19_RS06125	COG2346	COG2346, Truncated hemoglobins
M1D19_RS06130	COG4116	CYTH
M1D19_RS06140	COG2357	RelA SpoT domain protein
M1D19_RS06150	COG0564	pseudouridine synthase activity
M1D19_RS06170	COG1216	Glycosyl transferase, family 2
M1D19_RS06170	COG0463	Glycosyl transferase, family 2
M1D19_RS06190	COG0463	Glycosyl transferase, family 2
M1D19_RS06190	COG0457	Tetratricopeptide repeat
M1D19_RS06210	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M1D19_RS06225	COG1091	dTDP-4-dehydrorhamnose reductase activity
M1D19_RS06270	COG2153	protein acetylation
M1D19_RS06280	COG2382	esterase
M1D19_RS06295	COG5492	domain, Protein
M1D19_RS06300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1D19_RS06310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1D19_RS06310	COG0512	Glutamine amidotransferase of anthranilate synthase
M1D19_RS06345	COG1620	l-lactate permease
M1D19_RS06350	COG5634	Uncharacterized conserved protein (DUF2278)
M1D19_RS06405	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1D19_RS06415	COG1476	TRANSCRIPTIONal
M1D19_RS06475	COG2226	methyltransferase
M1D19_RS06485	COG1686	Belongs to the peptidase S11 family
M1D19_RS06490	COG0681	Belongs to the peptidase S26 family
M1D19_RS06525	COG1012	belongs to the aldehyde dehydrogenase family
M1D19_RS06530	COG3842	ATPase activity
M1D19_RS06535	COG1176	ABC-type spermidine putrescine transport system, permease component I
M1D19_RS06540	COG1177	transmembrane transport
M1D19_RS06545	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M1D19_RS06555	COG2409	Drug exporters of the RND superfamily
M1D19_RS06565	COG0564	pseudouridine synthase activity
M1D19_RS06575	COG2340	Cysteine-rich secretory protein family
M1D19_RS06580	COG0247	lactate metabolic process
M1D19_RS06585	COG0277	FAD linked oxidase domain protein
M1D19_RS06590	COG3835	regulator
M1D19_RS06600	COG0745	RESPONSE REGULATOR receiver
M1D19_RS06605	COG5002	protein histidine kinase activity
M1D19_RS06610	COG2186	Transcriptional regulator
M1D19_RS06630	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1D19_RS06640	COG2116	formate transmembrane transporter activity
M1D19_RS06645	COG0861	Integral membrane protein TerC family
M1D19_RS06650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1D19_RS06660	COG2030	dehydratase
M1D19_RS06680	COG1028	Short-chain dehydrogenase reductase Sdr
M1D19_RS06685	COG3243	poly(R)-hydroxyalkanoic acid synthase
M1D19_RS06690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1D19_RS06695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1D19_RS06710	COG1840	ABC-type Fe3 transport system, periplasmic component
M1D19_RS06740	COG1349	DNA-binding transcription factor activity
M1D19_RS06760	COG2861	carbohydrate metabolic process
M1D19_RS06770	COG3852	Histidine kinase
M1D19_RS06775	COG1846	Transcriptional regulator
M1D19_RS06785	COG2318	DinB family
M1D19_RS06795	COG5002	protein histidine kinase activity
M1D19_RS06805	COG0720	synthase
M1D19_RS06820	COG4873	Protein conserved in bacteria
M1D19_RS06850	COG1780	Probably involved in ribonucleotide reductase function
M1D19_RS06870	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1D19_RS06875	COG1725	Transcriptional regulator
M1D19_RS06880	COG1131	(ABC) transporter
M1D19_RS06890	COG1131	(ABC) transporter
M1D19_RS06895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M1D19_RS06910	COG1522	sequence-specific DNA binding
M1D19_RS06920	COG1335	isochorismatase
M1D19_RS06930	COG1619	proteins homologs of microcin C7 resistance protein MccF
M1D19_RS06935	COG2070	2-Nitropropane dioxygenase
M1D19_RS06940	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M1D19_RS06950	COG1696	Membrane protein involved in D-alanine export
M1D19_RS06970	COG0716	FMN binding
M1D19_RS06985	COG3173	Aminoglycoside phosphotransferase
M1D19_RS07005	COG0534	Mate efflux family protein
M1D19_RS07010	COG1968	undecaprenyl-diphosphatase activity
M1D19_RS07025	COG1846	Transcriptional regulator
M1D19_RS07035	COG1301	dicarboxylic acid transport
M1D19_RS07040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1D19_RS07045	COG4709	membrane
M1D19_RS07050	COG3874	Sporulation protein YtfJ
M1D19_RS07075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1D19_RS07080	COG0028	Belongs to the TPP enzyme family
M1D19_RS07085	COG0440	acetolactate synthase activity
M1D19_RS07090	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M1D19_RS07100	COG0473	3-isopropylmalate dehydrogenase activity
M1D19_RS07125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1D19_RS07160	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M1D19_RS07175	COG1183	phosphatidylcholine synthase activity
M1D19_RS07180	COG1368	sulfuric ester hydrolase activity
M1D19_RS07190	COG0019	diaminopimelate decarboxylase activity
M1D19_RS07210	COG0529	Catalyzes the synthesis of activated sulfate
M1D19_RS07215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1D19_RS07235	COG1648	precorrin-2 dehydrogenase activity
M1D19_RS07240	COG0733	neurotransmitter:sodium symporter activity
M1D19_RS07260	COG1757	Na H antiporter
M1D19_RS07275	COG4758	membrane
M1D19_RS07280	COG4585	Histidine kinase
M1D19_RS07285	COG2197	response regulator
M1D19_RS07295	COG1114	Component of the transport system for branched-chain amino acids
M1D19_RS07305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1D19_RS07330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1D19_RS07330	COG1017	nitric oxide dioxygenase activity
M1D19_RS07345	COG0730	response to heat
M1D19_RS07350	COG0306	phosphate transporter
M1D19_RS07355	COG1392	Phosphate transport regulator
M1D19_RS07360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1D19_RS07380	COG1801	Protein of unknown function DUF72
M1D19_RS07390	COG0582	viral genome integration into host DNA
M1D19_RS07395	COG5002	protein histidine kinase activity
M1D19_RS07415	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M1D19_RS07415	COG0392	lysyltransferase activity
M1D19_RS07430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1D19_RS07435	COG1686	Belongs to the peptidase S11 family
M1D19_RS07440	COG2715	membrane protein required for spore maturation
M1D19_RS07445	COG0700	Nucleoside recognition
M1D19_RS07450	COG1187	pseudouridine synthase activity
M1D19_RS07460	COG1333	cytochrome c biogenesis protein
M1D19_RS07465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M1D19_RS07470	COG0745	RESPONSE REGULATOR receiver
M1D19_RS07475	COG5002	protein histidine kinase activity
M1D19_RS07480	COG2096	Adenosyltransferase
M1D19_RS07495	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M1D19_RS07500	COG1141	Ferredoxin
M1D19_RS07505	COG4955	Helix-turn-helix domain
M1D19_RS07510	COG0514	ATP-dependent DNA helicase (RecQ)
M1D19_RS07515	COG1266	CAAX protease self-immunity
M1D19_RS07535	COG4862	establishment of competence for transformation
M1D19_RS07540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1D19_RS07560	COG0492	ferredoxin-NADP+ reductase activity
M1D19_RS07635	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M1D19_RS07650	COG0142	geranyltranstransferase activity
M1D19_RS07660	COG0142	geranyltranstransferase activity
M1D19_RS07680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M1D19_RS07685	COG0457	Tetratricopeptide repeat
M1D19_RS07705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M1D19_RS07715	COG4347	Protein of unknown function (DUF1405)
M1D19_RS07730	COG2738	Putative neutral zinc metallopeptidase
M1D19_RS07740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1D19_RS07745	COG1694	Mazg nucleotide pyrophosphohydrolase
M1D19_RS07760	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M1D19_RS07765	COG0438	transferase activity, transferring glycosyl groups
M1D19_RS07800	COG1199	ATP-dependent helicase activity
M1D19_RS07800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1D19_RS07820	COG3935	DnaD domain protein
M1D19_RS07825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1D19_RS07835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1D19_RS07835	COG4499	WXG100 protein secretion system (Wss), protein YukC
M1D19_RS07895	COG0116	Belongs to the methyltransferase superfamily
M1D19_RS07905	COG1199	ATP-dependent helicase activity
M1D19_RS07910	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M1D19_RS07920	COG3173	Aminoglycoside phosphotransferase
M1D19_RS07925	COG0024	Methionine aminopeptidase
M1D19_RS07935	COG2233	PERMEase
M1D19_RS07940	COG2311	Membrane
M1D19_RS07945	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M1D19_RS07955	COG0456	acetyltransferase
M1D19_RS08005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1D19_RS08030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M1D19_RS08045	COG1215	transferase activity, transferring glycosyl groups
M1D19_RS08050	COG0438	transferase activity, transferring glycosyl groups
M1D19_RS08065	COG0454	-acetyltransferase
M1D19_RS08085	COG0328	RNA-DNA hybrid ribonuclease activity
M1D19_RS08125	COG1280	lysine exporter protein (LysE YggA)
M1D19_RS08140	COG3162	membrane
M1D19_RS08145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1D19_RS08150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M1D19_RS08160	COG0475	glutathione-regulated potassium exporter activity
M1D19_RS08165	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M1D19_RS08170	COG4978	Transcriptional regulator
M1D19_RS08170	COG0789	Transcriptional regulator
M1D19_RS08180	COG2323	membrane
M1D19_RS08185	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M1D19_RS08240	COG1923	regulation of RNA biosynthetic process
M1D19_RS08250	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M1D19_RS08255	COG1360	Flagellar Motor Protein
M1D19_RS08260	COG2201	protein-glutamate methylesterase activity
M1D19_RS08270	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M1D19_RS08270	COG1776	CheC inhibitor of MCP methylation
M1D19_RS08285	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M1D19_RS08305	COG1256	bacterial-type flagellum assembly
M1D19_RS08330	COG1815	bacterial-type flagellum-dependent cell motility
M1D19_RS08335	COG1558	bacterial-type flagellum-dependent cell motility
M1D19_RS08350	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M1D19_RS08360	COG1157	protein secretion by the type III secretion system
M1D19_RS08405	COG0463	Glycosyl transferase, family 2
M1D19_RS08435	COG0463	Glycosyl transferase, family 2
M1D19_RS08435	COG0457	Tetratricopeptide repeat
M1D19_RS08450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M1D19_RS08455	COG0741	lytic transglycosylase activity
M1D19_RS08470	COG1776	CheC inhibitor of MCP methylation
M1D19_RS08470	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M1D19_RS08480	COG1338	Plays a role in the flagellum-specific transport system
M1D19_RS08485	COG1987	bacterial-type flagellum assembly
M1D19_RS08495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M1D19_RS08500	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M1D19_RS08510	COG4786	Flagellar basal body rod
M1D19_RS08515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M1D19_RS08540	COG1309	transcriptional regulator
M1D19_RS08560	COG2329	Antibiotic biosynthesis monooxygenase
M1D19_RS08585	COG0583	DNA-binding transcription factor activity
M1D19_RS08595	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1D19_RS08605	COG1234	tRNA 3'-trailer cleavage
M1D19_RS08630	COG1686	Belongs to the peptidase S11 family
M1D19_RS08640	COG0406	alpha-ribazole phosphatase activity
M1D19_RS08670	COG0367	asparagine synthase
M1D19_RS08700	COG1802	Transcriptional regulator
M1D19_RS08705	COG0697	spore germination
M1D19_RS08710	COG0523	cobalamin synthesis protein
M1D19_RS08715	COG0701	Predicted permease
M1D19_RS08725	COG1216	Glycosyl transferase, family 2
M1D19_RS08725	COG0438	transferase activity, transferring glycosyl groups
M1D19_RS08730	COG1757	Na H antiporter
M1D19_RS08735	COG0114	fumarate hydratase activity
M1D19_RS08760	COG3340	Belongs to the peptidase S51 family
M1D19_RS08780	COG0785	Cytochrome C biogenesis protein
M1D19_RS08810	COG2733	membrane
M1D19_RS08845	COG1131	(ABC) transporter
M1D19_RS08860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1D19_RS08865	COG0528	UMP kinase activity
M1D19_RS08875	COG1027	Aspartate ammonia-lyase
M1D19_RS08890	COG1063	alcohol dehydrogenase
M1D19_RS08925	COG1280	lysine exporter protein (LysE YggA)
M1D19_RS08930	COG3403	YqcI/YcgG family
M1D19_RS08935	COG5577	PFAM Coat F domain
M1D19_RS08950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1D19_RS08955	COG0574	Belongs to the PEP-utilizing enzyme family
M1D19_RS08955	COG3848	Pyruvate phosphate dikinase
M1D19_RS08970	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M1D19_RS08985	COG3314	Sporulation integral membrane protein YlbJ
M1D19_RS09000	COG1960	acyl-CoA dehydrogenase activity
M1D19_RS09010	COG0640	Transcriptional regulator
M1D19_RS09015	COG0860	N-Acetylmuramoyl-L-alanine amidase
M1D19_RS09030	COG1414	Transcriptional regulator
M1D19_RS09035	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M1D19_RS09070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1D19_RS09080	COG0768	penicillin binding
M1D19_RS09120	COG4335	DNA alkylation repair
M1D19_RS09130	COG0833	amino acid
M1D19_RS09140	COG0730	response to heat
M1D19_RS09170	COG0596	Alpha beta hydrolase
M1D19_RS09175	COG0745	RESPONSE REGULATOR receiver
M1D19_RS09180	COG0642	Histidine kinase
M1D19_RS09200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1D19_RS09220	COG0456	acetyltransferase
M1D19_RS09225	COG2207	Transcriptional regulator
M1D19_RS09250	COG0577	efflux transmembrane transporter activity
M1D19_RS09250	COG1136	(ABC) transporter
M1D19_RS09260	COG1725	Transcriptional regulator
M1D19_RS09300	COG1846	Transcriptional regulator
M1D19_RS09305	COG0778	Nitroreductase
M1D19_RS09315	COG0714	Associated with various cellular activities
M1D19_RS09340	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1D19_RS09350	COG0753	catalase activity
M1D19_RS09355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1D19_RS09365	COG0463	Glycosyl transferase, family 2
M1D19_RS09385	COG0463	Glycosyl transferase, family 2
M1D19_RS09410	COG0714	Associated with various cellular activities
M1D19_RS09430	COG0346	lactoylglutathione lyase activity
M1D19_RS09435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1D19_RS09445	COG3279	Response regulator of the LytR AlgR family
M1D19_RS09455	COG4377	Putative membrane peptidase family (DUF2324)
M1D19_RS09470	COG3655	Transcriptional regulator
M1D19_RS09480	COG1785	Belongs to the alkaline phosphatase family
M1D19_RS09490	COG1690	Belongs to the RtcB family
M1D19_RS09495	COG0833	amino acid
M1D19_RS09500	COG1414	Transcriptional regulator
M1D19_RS09505	COG4187	Peptidase family M20/M25/M40
M1D19_RS09510	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M1D19_RS09515	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M1D19_RS09525	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M1D19_RS09545	COG2329	Antibiotic biosynthesis monooxygenase
M1D19_RS09580	COG2390	Transcriptional regulator
M1D19_RS09590	COG1172	Belongs to the binding-protein-dependent transport system permease family
M1D19_RS09600	COG1879	ABC-type sugar transport system periplasmic component
M1D19_RS09625	COG1595	DNA-templated transcription, initiation
M1D19_RS09635	COG3584	3D domain protein
M1D19_RS09635	COG1388	LysM domain
M1D19_RS09670	COG1605	Chorismate mutase
M1D19_RS09670	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M1D19_RS09675	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M1D19_RS09680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M1D19_RS09685	COG0287	Prephenate dehydrogenase
M1D19_RS09700	COG1309	transcriptional regulator
M1D19_RS09715	COG0488	(ABC) transporter
M1D19_RS09720	COG1368	sulfuric ester hydrolase activity
M1D19_RS09725	COG0861	Integral membrane protein TerC family
M1D19_RS09745	COG4912	Dna alkylation repair
M1D19_RS09765	COG2318	DinB family
M1D19_RS09770	COG0697	spore germination
M1D19_RS09795	COG2746	aminoglycoside 3-N-acetyltransferase activity
M1D19_RS09815	COG2816	NAD+ diphosphatase activity
M1D19_RS09835	COG1116	anion transmembrane transporter activity
M1D19_RS09840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1D19_RS09845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1D19_RS09850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1D19_RS09865	COG0628	permease
M1D19_RS09930	COG5146	pantothenate kinase activity
M1D19_RS09935	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M1D19_RS09940	COG0436	Aminotransferase
M1D19_RS09975	COG2226	methyltransferase
M1D19_RS09990	COG2261	transglycosylase associated protein
M1D19_RS10010	COG0477	Major facilitator Superfamily
M1D19_RS10010	COG2814	Major facilitator Superfamily
M1D19_RS10015	COG4533	DNA binding
M1D19_RS10020	COG0789	Transcriptional regulator
M1D19_RS10025	COG1664	Polymer-forming cytoskeletal
M1D19_RS10035	COG2814	Major facilitator Superfamily
M1D19_RS10055	COG1307	EDD domain protein, DegV family
M1D19_RS10105	COG5002	protein histidine kinase activity
M1D19_RS10110	COG2936	dipeptidyl-peptidase activity
M1D19_RS10155	COG4948	Mandelate Racemase Muconate Lactonizing
M1D19_RS10165	COG4166	transmembrane transport
M1D19_RS10170	COG0519	Catalyzes the synthesis of GMP from XMP
M1D19_RS10175	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M1D19_RS10190	COG0586	Pfam SNARE associated Golgi protein
M1D19_RS10230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1D19_RS10235	COG3938	Belongs to the proline racemase family
M1D19_RS10245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1D19_RS10250	COG1012	belongs to the aldehyde dehydrogenase family
M1D19_RS10255	COG1115	amino acid carrier protein
M1D19_RS10260	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1D19_RS10275	COG3397	chitin binding
M1D19_RS10300	COG4637	Psort location Cytoplasmic, score
M1D19_RS10320	COG0514	ATP-dependent DNA helicase (RecQ)
M1D19_RS10325	COG2105	PFAM AIG2 family protein
M1D19_RS10340	COG3973	AAA domain
M1D19_RS10390	COG0658	competence protein
M1D19_RS10390	COG2333	competence protein COMEC
M1D19_RS10420	COG2205	protein histidine kinase activity
M1D19_RS10435	COG3397	chitin binding
M1D19_RS10440	COG2153	protein acetylation
M1D19_RS10445	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M1D19_RS10470	COG0517	IMP dehydrogenase activity
M1D19_RS10470	COG4175	Glycine betaine
M1D19_RS10475	COG4176	ABC-type proline glycine betaine transport system permease component
M1D19_RS10505	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1D19_RS10505	COG0456	acetyltransferase
M1D19_RS10510	COG1028	Short-chain dehydrogenase reductase Sdr
M1D19_RS10520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1D19_RS10525	COG0022	dehydrogenase e1 component
M1D19_RS10530	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1D19_RS10535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1D19_RS10550	COG1959	2 iron, 2 sulfur cluster binding
M1D19_RS10570	COG1349	DNA-binding transcription factor activity
M1D19_RS10590	COG3284	Transcriptional regulator
M1D19_RS10620	COG1309	transcriptional regulator
M1D19_RS10625	COG3844	kynureninase activity
M1D19_RS10630	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
M1D19_RS10635	COG3483	tryptophan 2,3-dioxygenase activity
M1D19_RS10655	COG2959	enzyme of heme biosynthesis
M1D19_RS10670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1D19_RS10675	COG4129	membrane
M1D19_RS10705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1D19_RS10710	COG0697	spore germination
M1D19_RS10720	COG0201	protein transport
M1D19_RS10740	COG3227	Zinc metalloprotease (Elastase)
M1D19_RS10745	COG1523	belongs to the glycosyl hydrolase 13 family
M1D19_RS10760	COG0076	glutamate decarboxylase activity
M1D19_RS10780	COG1011	Hydrolase
M1D19_RS10805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1D19_RS10845	COG0322	excinuclease ABC activity
M1D19_RS10860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1D19_RS10910	COG3878	Protein conserved in bacteria
M1D19_RS10945	COG1051	belongs to the nudix hydrolase family
M1D19_RS10950	COG0592	DNA-directed DNA polymerase activity
M1D19_RS10955	COG2816	NAD+ diphosphatase activity
M1D19_RS10970	COG2223	nitrite transmembrane transporter activity
M1D19_RS10980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1D19_RS11010	COG0697	spore germination
M1D19_RS11030	COG0584	glycerophosphoryl diester phosphodiesterase
M1D19_RS11045	COG2814	Major facilitator Superfamily
M1D19_RS11075	COG0693	protein deglycase activity
M1D19_RS11110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1D19_RS11120	COG0768	penicillin binding
M1D19_RS11125	COG0604	alcohol dehydrogenase
M1D19_RS11130	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1D19_RS11140	COG2205	protein histidine kinase activity
M1D19_RS11155	COG1122	ATPase activity
M1D19_RS11165	COG1794	racemase activity, acting on amino acids and derivatives
M1D19_RS11170	COG1819	glycosyl
M1D19_RS11175	COG0768	penicillin binding
M1D19_RS11185	COG0561	phosphatase activity
M1D19_RS11220	COG2124	cytochrome p450
M1D19_RS11290	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1D19_RS11300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1D19_RS11305	COG0460	homoserine dehydrogenase
M1D19_RS11330	COG1136	(ABC) transporter
M1D19_RS11360	COG0745	RESPONSE REGULATOR receiver
M1D19_RS11370	COG3773	Cell wall hydrolase
M1D19_RS11385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1D19_RS11390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1D19_RS11405	COG1063	alcohol dehydrogenase
M1D19_RS11420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1D19_RS11440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1D19_RS11460	COG2814	Major facilitator Superfamily
M1D19_RS11485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1D19_RS11485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1D19_RS11525	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1D19_RS11555	COG2318	DinB family
M1D19_RS11565	COG0572	uridine kinase
M1D19_RS11570	COG1247	-acetyltransferase
M1D19_RS11580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1D19_RS11585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1D19_RS11590	COG1024	Enoyl-CoA hydratase
M1D19_RS11595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1D19_RS11600	COG0511	ligase activity, forming carbon-carbon bonds
M1D19_RS11605	COG0439	Biotin carboxylase
M1D19_RS11610	COG1960	acyl-CoA dehydrogenase activity
M1D19_RS11625	COG1309	transcriptional regulator
M1D19_RS11635	COG1131	(ABC) transporter
M1D19_RS11650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M1D19_RS11655	COG1252	NADH dehydrogenase
M1D19_RS11670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1D19_RS11685	COG0488	(ABC) transporter
M1D19_RS11690	COG1309	transcriptional regulator
M1D19_RS11710	COG1876	peptidase activity
M1D19_RS11725	COG1476	TRANSCRIPTIONal
M1D19_RS11730	COG0457	Tetratricopeptide repeat
M1D19_RS11755	COG3718	enzyme involved in inositol metabolism
M1D19_RS11760	COG0191	fructose-bisphosphate aldolase activity
M1D19_RS11775	COG1012	belongs to the aldehyde dehydrogenase family
M1D19_RS11785	COG0673	inositol 2-dehydrogenase activity
M1D19_RS11790	COG2814	Major facilitator Superfamily
M1D19_RS11795	COG1609	Transcriptional regulator
M1D19_RS11800	COG0671	phosphoesterase, PA-phosphatase related
M1D19_RS11805	COG2367	Beta-lactamase
M1D19_RS11825	COG1595	DNA-templated transcription, initiation
M1D19_RS11840	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1D19_RS11885	COG1846	Transcriptional regulator
M1D19_RS11890	COG3961	Belongs to the TPP enzyme family
M1D19_RS11895	COG2226	methyltransferase
M1D19_RS11905	COG3615	Tellurite resistance protein tehB
M1D19_RS11905	COG0500	methyltransferase
M1D19_RS11910	COG0577	efflux transmembrane transporter activity
M1D19_RS11910	COG1136	(ABC) transporter
M1D19_RS11925	COG1309	transcriptional regulator
M1D19_RS11955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1D19_RS11975	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1D19_RS11980	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M1D19_RS11985	COG2971	BadF BadG BcrA BcrD
M1D19_RS12010	COG1649	PFAM Uncharacterised BCR, COG1649
M1D19_RS12035	COG1595	DNA-templated transcription, initiation
M1D19_RS12040	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
M1D19_RS12065	COG1396	sequence-specific DNA binding
M1D19_RS12085	COG1132	(ABC) transporter
M1D19_RS12090	COG1132	(ABC) transporter
M1D19_RS12105	COG2258	MOSC domain
M1D19_RS12110	COG0583	DNA-binding transcription factor activity
M1D19_RS12125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M1D19_RS12130	COG0583	DNA-binding transcription factor activity
M1D19_RS12175	COG0561	phosphatase activity
M1D19_RS12180	COG0010	Belongs to the arginase family
M1D19_RS12195	COG1278	Cold shock
M1D19_RS12205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1D19_RS12215	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M1D19_RS12245	COG1247	-acetyltransferase
M1D19_RS12280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1D19_RS12325	COG2226	methyltransferase
M1D19_RS12345	COG2814	Major facilitator Superfamily
M1D19_RS12350	COG0596	Alpha beta hydrolase
M1D19_RS12365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M1D19_RS12370	COG1187	pseudouridine synthase activity
M1D19_RS12375	COG2329	Antibiotic biosynthesis monooxygenase
M1D19_RS12390	COG1115	amino acid carrier protein
M1D19_RS12400	COG2318	DinB family
M1D19_RS12410	COG0776	regulation of translation
M1D19_RS12425	COG2814	Major facilitator Superfamily
M1D19_RS12430	COG3251	PFAM MbtH domain protein
M1D19_RS12435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1D19_RS12440	COG1535	isochorismatase
M1D19_RS12440	COG3433	isochorismatase activity
M1D19_RS12445	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1D19_RS12450	COG1169	isochorismate synthase
M1D19_RS12455	COG1028	Short-chain dehydrogenase reductase Sdr
M1D19_RS12460	COG2223	nitrite transmembrane transporter activity
M1D19_RS12485	COG0419	ATPase involved in DNA repair
M1D19_RS12490	COG0420	3'-5' exonuclease activity
M1D19_RS12505	COG1024	Enoyl-CoA hydratase
M1D19_RS12510	COG1280	lysine exporter protein (LysE YggA)
M1D19_RS12520	COG2084	Dehydrogenase
M1D19_RS12525	COG1960	acyl-CoA dehydrogenase activity
M1D19_RS12530	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M1D19_RS12535	COG2079	MmgE PrpD family protein
M1D19_RS12540	COG0372	Belongs to the citrate synthase family
M1D19_RS12545	COG4841	protein insertion into membrane
M1D19_RS12550	COG2814	Major facilitator Superfamily
M1D19_RS12560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1D19_RS12560	COG4499	WXG100 protein secretion system (Wss), protein YukC
M1D19_RS12600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1D19_RS12695	COG1715	Restriction endonuclease
M1D19_RS12695	COG1787	Restriction endonuclease
M1D19_RS12725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1D19_RS12730	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M1D19_RS12735	COG0671	phosphoesterase, PA-phosphatase related
M1D19_RS12740	COG4326	sporulation control protein
M1D19_RS12780	COG1509	lysine 2,3-aminomutase activity
M1D19_RS12785	COG3829	transcription factor binding
M1D19_RS12790	COG0456	acetyltransferase
M1D19_RS12795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1D19_RS12800	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1D19_RS12805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1D19_RS12810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M1D19_RS12825	COG5506	Protein of unknown function (DUF1694)
M1D19_RS12830	COG1012	belongs to the aldehyde dehydrogenase family
M1D19_RS12835	COG1253	flavin adenine dinucleotide binding
M1D19_RS12870	COG1174	glycine betaine transport
M1D19_RS12875	COG1125	glycine betaine transport
M1D19_RS12875	COG0517	IMP dehydrogenase activity
M1D19_RS12930	COG1064	alcohol dehydrogenase
M1D19_RS12940	COG2197	response regulator
M1D19_RS12945	COG2203	Gaf domain
M1D19_RS12945	COG4585	Histidine kinase
M1D19_RS12950	COG0668	transmembrane transport
M1D19_RS12985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1D19_RS12990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1D19_RS13005	COG0367	asparagine synthase
M1D19_RS13010	COG0071	Belongs to the small heat shock protein (HSP20) family
M1D19_RS13015	COG1999	signal sequence binding
M1D19_RS13020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M1D19_RS13025	COG1307	EDD domain protein, DegV family
M1D19_RS13035	COG0805	protein transport
M1D19_RS13045	COG1272	protein, Hemolysin III
M1D19_RS13050	COG0204	Acyl-transferase
M1D19_RS13055	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1D19_RS13060	COG0768	penicillin binding
M1D19_RS13075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1D19_RS13095	COG0546	phosphoglycolate phosphatase activity
M1D19_RS13110	COG1131	(ABC) transporter
M1D19_RS13125	COG0456	acetyltransferase
M1D19_RS13135	COG1794	racemase activity, acting on amino acids and derivatives
M1D19_RS13140	COG1454	alcohol dehydrogenase
M1D19_RS13145	COG2610	gluconate transmembrane transporter activity
M1D19_RS13170	COG0733	neurotransmitter:sodium symporter activity
M1D19_RS13185	COG5002	protein histidine kinase activity
M1D19_RS13185	COG3850	Histidine kinase
M1D19_RS13190	COG0745	RESPONSE REGULATOR receiver
M1D19_RS13195	COG0471	metal ion transport
M1D19_RS13200	COG1929	Belongs to the glycerate kinase type-1 family
M1D19_RS13270	COG1674	ftsk spoiiie
M1D19_RS13290	COG0017	Asparaginyl-tRNA synthetase
M1D19_RS13310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1D19_RS13335	COG0018	arginyl-trna synthetase
M1D19_RS13340	COG2521	methyltransferase
M1D19_RS13340	COG2136	Putative SAM-dependent methyltransferase
M1D19_RS13355	COG1413	lyase activity
M1D19_RS13370	COG0629	single-stranded DNA binding
M1D19_RS13385	COG0488	(ABC) transporter
M1D19_RS13390	COG1418	mRNA catabolic process
M1D19_RS13415	COG2359	stage V sporulation protein S
M1D19_RS13450	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
M1D19_RS13455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1D19_RS13460	COG2146	nitrite reductase [NAD(P)H] activity
M1D19_RS13465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1D19_RS13465	COG1587	Uroporphyrinogen-III synthase
M1D19_RS13475	COG1648	precorrin-2 dehydrogenase activity
M1D19_RS13490	COG2223	nitrite transmembrane transporter activity
M1D19_RS13500	COG0314	molybdopterin synthase activity
M1D19_RS13505	COG0303	'Molybdopterin
M1D19_RS13510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M1D19_RS13515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1D19_RS13520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1D19_RS13540	COG2181	nitrate reductase activity
M1D19_RS13545	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M1D19_RS13550	COG1140	nitrate reductase beta subunit
M1D19_RS13555	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M1D19_RS13570	COG0714	Associated with various cellular activities
M1D19_RS13575	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
M1D19_RS13580	COG1305	Transglutaminase-like
M1D19_RS13585	COG0386	Belongs to the glutathione peroxidase family
M1D19_RS13610	COG1595	DNA-templated transcription, initiation
M1D19_RS13615	COG0604	alcohol dehydrogenase
M1D19_RS13625	COG0346	lactoylglutathione lyase activity
M1D19_RS13650	COG2226	methyltransferase
M1D19_RS13675	COG3874	Sporulation protein YtfJ
M1D19_RS13730	COG0456	acetyltransferase
M1D19_RS13765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1D19_RS13770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1D19_RS13775	COG1819	glycosyl
M1D19_RS13790	COG4106	trans-aconitate 2-methyltransferase activity
M1D19_RS13795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1D19_RS13805	COG0561	phosphatase activity
M1D19_RS13825	COG2211	Major facilitator Superfamily
M1D19_RS13830	COG0154	amidase activity
M1D19_RS13840	COG1876	peptidase activity
M1D19_RS13850	COG0860	N-Acetylmuramoyl-L-alanine amidase
M1D19_RS13870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1D19_RS13875	COG1114	Component of the transport system for branched-chain amino acids
M1D19_RS13890	COG1253	flavin adenine dinucleotide binding
M1D19_RS13895	COG2839	Protein conserved in bacteria
M1D19_RS13900	COG0702	epimerase
M1D19_RS13925	COG1607	acyl-coa hydrolase
M1D19_RS13930	COG3689	TIGRFAM TIGR03943 family protein
M1D19_RS13935	COG0701	Predicted permease
M1D19_RS13945	COG2244	polysaccharide biosynthetic process
M1D19_RS13950	COG0586	Pfam SNARE associated Golgi protein
M1D19_RS13955	COG1051	belongs to the nudix hydrolase family
M1D19_RS13960	COG5337	Spore coat protein CotH
M1D19_RS13970	COG0406	alpha-ribazole phosphatase activity
M1D19_RS13985	COG4166	transmembrane transport
M1D19_RS13995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1D19_RS14005	COG0702	epimerase
M1D19_RS14015	COG0803	Belongs to the bacterial solute-binding protein 9 family
M1D19_RS14015	COG3443	Belongs to the bacterial solute-binding protein 9 family
M1D19_RS14075	COG0456	acetyltransferase
M1D19_RS14080	COG0523	cobalamin synthesis protein
M1D19_RS14085	COG4989	oxidoreductase activity
M1D19_RS14095	COG1231	oxidoreductase activity
M1D19_RS14105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1D19_RS14120	COG0783	Belongs to the Dps family
M1D19_RS14125	COG3949	Membrane
M1D19_RS14140	COG0840	transmembrane signaling receptor activity
M1D19_RS14165	COG2814	Major facilitator Superfamily
M1D19_RS14170	COG0667	Aldo Keto reductase
M1D19_RS14175	COG0640	Transcriptional regulator
M1D19_RS14180	COG1404	Belongs to the peptidase S8 family
M1D19_RS14185	COG2002	toxin-antitoxin pair type II binding
M1D19_RS14225	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1D19_RS14235	COG1279	arginine transmembrane transporter activity
M1D19_RS14250	COG1082	Xylose isomerase domain protein TIM barrel
M1D19_RS14260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1D19_RS14280	COG1247	-acetyltransferase
M1D19_RS14285	COG1285	pathogenesis
M1D19_RS14300	COG5002	protein histidine kinase activity
M1D19_RS14305	COG0745	RESPONSE REGULATOR receiver
M1D19_RS14315	COG1316	TRANSCRIPTIONal
M1D19_RS14340	COG0460	homoserine dehydrogenase
M1D19_RS14375	COG0300	oxidoreductase activity
M1D19_RS14385	COG5002	protein histidine kinase activity
M1D19_RS14390	COG0745	RESPONSE REGULATOR receiver
M1D19_RS14405	COG1388	LysM domain
M1D19_RS14405	COG0791	NLP P60 protein
M1D19_RS14420	COG1686	Belongs to the peptidase S11 family
M1D19_RS14440	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M1D19_RS14445	COG4988	ABC transporter
M1D19_RS14450	COG1294	oxidase, subunit
M1D19_RS14455	COG1271	oxidase subunit
M1D19_RS14465	COG1846	Transcriptional regulator
M1D19_RS14475	COG1942	4-Oxalocrotonate Tautomerase
M1D19_RS14485	COG0583	DNA-binding transcription factor activity
M1D19_RS14505	COG0411	ABC transporter
M1D19_RS14515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M1D19_RS14520	COG2030	dehydratase
M1D19_RS14525	COG0318	PFAM AMP-dependent synthetase and ligase
M1D19_RS14540	COG0523	cobalamin synthesis protein
M1D19_RS14545	COG1231	oxidoreductase activity
M1D19_RS14555	COG0628	permease
M1D19_RS14570	COG0778	Nitroreductase
M1D19_RS14575	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1D19_RS14580	COG1959	2 iron, 2 sulfur cluster binding
M1D19_RS14585	COG0583	DNA-binding transcription factor activity
M1D19_RS14590	COG0697	spore germination
M1D19_RS14600	COG4549	nuclear export factor GLE1
M1D19_RS14605	COG2372	response to copper ion
M1D19_RS14605	COG1276	copper resistance
M1D19_RS14620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1D19_RS14635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M1D19_RS14650	COG2132	Multicopper oxidase
M1D19_RS14655	COG0006	proline dipeptidase activity
M1D19_RS14675	COG4224	UPF0291 protein
M1D19_RS14690	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M1D19_RS14695	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M1D19_RS14705	COG2390	Transcriptional regulator
M1D19_RS14740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M1D19_RS14755	COG1914	H( )-stimulated, divalent metal cation uptake system
M1D19_RS14775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1D19_RS14780	COG0535	radical SAM domain protein
M1D19_RS14810	COG1073	alpha beta
M1D19_RS14830	COG0427	acetyl-CoA hydrolase
M1D19_RS14835	COG3279	Response regulator of the LytR AlgR family
M1D19_RS14845	COG3384	dioxygenase
M1D19_RS14850	COG2814	Major facilitator Superfamily
M1D19_RS14875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1D19_RS14885	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M1D19_RS14890	COG0440	acetolactate synthase activity
M1D19_RS14895	COG0028	Belongs to the TPP enzyme family
M1D19_RS14900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1D19_RS14910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M1D19_RS14925	COG2084	Dehydrogenase
M1D19_RS14940	COG2323	membrane
M1D19_RS14945	COG5566	PFAM Mor transcription activator
M1D19_RS14955	COG0733	neurotransmitter:sodium symporter activity
M1D19_RS14960	COG2244	polysaccharide biosynthetic process
M1D19_RS14975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1D19_RS14980	COG2223	nitrite transmembrane transporter activity
M1D19_RS14990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1D19_RS15000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M1D19_RS15015	COG1966	Carbon starvation protein
M1D19_RS15030	COG2814	Major facilitator Superfamily
M1D19_RS15040	COG0860	N-Acetylmuramoyl-L-alanine amidase
M1D19_RS15100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M1D19_RS15105	COG0784	Response regulator, receiver
M1D19_RS15110	COG4191	Histidine kinase
M1D19_RS15115	COG0281	malic enzyme
M1D19_RS15120	COG1027	Aspartate ammonia-lyase
M1D19_RS15125	COG0252	asparaginase activity
M1D19_RS15130	COG1396	sequence-specific DNA binding
M1D19_RS15140	COG0322	excinuclease ABC activity
M1D19_RS15145	COG0531	amino acid
M1D19_RS15150	COG1114	Component of the transport system for branched-chain amino acids
M1D19_RS15155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M1D19_RS15165	COG0281	malic enzyme
M1D19_RS15185	COG0531	amino acid
M1D19_RS15195	COG0784	Response regulator, receiver
M1D19_RS15205	COG2066	Belongs to the glutaminase family
M1D19_RS15240	COG0737	Belongs to the 5'-nucleotidase family
M1D19_RS15245	COG0753	catalase activity
M1D19_RS15250	COG2267	carboxylic ester hydrolase activity
M1D19_RS15255	COG1335	isochorismatase
M1D19_RS15275	COG0583	DNA-binding transcription factor activity
M1D19_RS15325	COG0415	Belongs to the DNA photolyase family
M1D19_RS15330	COG0288	reversible hydration of carbon dioxide
M1D19_RS15340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1D19_RS15345	COG5609	conserved protein (DUF2294)
M1D19_RS15360	COG1575	Belongs to the MenA family. Type 1 subfamily
M1D19_RS15365	COG2267	carboxylic ester hydrolase activity
M1D19_RS15370	COG0803	Belongs to the bacterial solute-binding protein 9 family
M1D19_RS15375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1D19_RS15380	COG1121	(ABC) transporter
M1D19_RS15410	COG0798	PFAM Bile acid sodium symporter
M1D19_RS15415	COG0346	lactoylglutathione lyase activity
M1D19_RS15420	COG0640	Transcriptional regulator
M1D19_RS15435	COG0443	Heat shock 70 kDa protein
M1D19_RS15450	COG1522	sequence-specific DNA binding
M1D19_RS15465	COG0346	lactoylglutathione lyase activity
M1D19_RS15535	COG2814	Major facilitator Superfamily
M1D19_RS15560	COG0745	RESPONSE REGULATOR receiver
M1D19_RS15565	COG3850	Histidine kinase
M1D19_RS15565	COG5002	protein histidine kinase activity
M1D19_RS15590	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M1D19_RS15610	COG1476	TRANSCRIPTIONal
M1D19_RS15625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1D19_RS15630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1D19_RS15640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M1D19_RS15645	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
M1D19_RS15660	COG1136	(ABC) transporter
M1D19_RS15665	COG0577	efflux transmembrane transporter activity
M1D19_RS15680	COG3850	Histidine kinase
M1D19_RS15680	COG5002	protein histidine kinase activity
M1D19_RS15690	COG2364	Membrane
M1D19_RS15695	COG1846	Transcriptional regulator
M1D19_RS15705	COG2808	Putative FMN-binding domain
M1D19_RS15710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1D19_RS15715	COG2271	Major facilitator Superfamily
M1D19_RS15720	COG1556	Lactate utilization protein
M1D19_RS15725	COG1139	Iron-sulfur cluster binding protein
M1D19_RS15735	COG0583	DNA-binding transcription factor activity
M1D19_RS15745	COG1619	proteins homologs of microcin C7 resistance protein MccF
M1D19_RS15770	COG0738	Major facilitator superfamily
M1D19_RS15775	COG0673	inositol 2-dehydrogenase activity
M1D19_RS15780	COG0561	phosphatase activity
M1D19_RS15790	COG1609	Transcriptional regulator
M1D19_RS15795	COG0457	Tetratricopeptide repeat
M1D19_RS15815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1D19_RS15845	COG0534	Mate efflux family protein
M1D19_RS15870	COG2814	Major facilitator Superfamily
M1D19_RS15875	COG1309	transcriptional regulator
M1D19_RS15890	COG0814	amino acid
M1D19_RS15895	COG1760	l-serine dehydratase
M1D19_RS15900	COG1760	l-serine dehydratase
M1D19_RS15910	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1D19_RS15915	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
M1D19_RS15925	COG1335	isochorismatase
M1D19_RS15930	COG1522	sequence-specific DNA binding
M1D19_RS15935	COG0531	amino acid
M1D19_RS15955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1D19_RS15975	COG1595	DNA-templated transcription, initiation
M1D19_RS15990	COG0662	Cupin 2, conserved barrel domain protein
M1D19_RS15995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1D19_RS15995	COG2207	Transcriptional regulator
M1D19_RS16050	COG0477	Major facilitator Superfamily
M1D19_RS16060	COG1846	Transcriptional regulator
M1D19_RS16065	COG2814	Major facilitator Superfamily
M1D19_RS16075	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M1D19_RS16080	COG1131	(ABC) transporter
M1D19_RS16100	COG2076	Multidrug Resistance protein
M1D19_RS16105	COG1309	transcriptional regulator
M1D19_RS16115	COG2031	fatty acid transporter
M1D19_RS16125	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1D19_RS16155	COG1122	ATPase activity
M1D19_RS16160	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M1D19_RS16175	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1D19_RS16180	COG1288	antiporter activity
M1D19_RS16185	COG2356	endonuclease I
M1D19_RS16200	COG3620	sequence-specific DNA binding
M1D19_RS16205	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M1D19_RS16210	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1D19_RS16215	COG0124	histidyl-tRNA synthetase
M1D19_RS16230	COG1733	regulation of RNA biosynthetic process
M1D19_RS16235	COG0778	Nitroreductase
M1D19_RS16255	COG1028	Short-chain dehydrogenase reductase Sdr
M1D19_RS16265	COG1131	(ABC) transporter
M1D19_RS16290	COG1011	Hydrolase
M1D19_RS16300	COG2365	Tyrosine phosphatase family
M1D19_RS16325	COG0346	lactoylglutathione lyase activity
M1D19_RS16330	COG1940	carbohydrate kinase activity
M1D19_RS16335	COG0738	Major facilitator superfamily
M1D19_RS16340	COG0110	maltose O-acetyltransferase activity
M1D19_RS16350	COG0577	efflux transmembrane transporter activity
M1D19_RS16350	COG1136	(ABC) transporter
M1D19_RS16365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M1D19_RS16370	COG0628	permease
M1D19_RS16390	COG2226	methyltransferase
M1D19_RS16400	COG0477	Major facilitator Superfamily
M1D19_RS16430	COG1253	flavin adenine dinucleotide binding
M1D19_RS16435	COG0789	Transcriptional regulator
M1D19_RS16440	COG0697	spore germination
M1D19_RS16445	COG1357	PFAM Pentapeptide repeats (8 copies)
M1D19_RS16450	COG3813	Protein conserved in bacteria
M1D19_RS16455	COG2706	6-phosphogluconolactonase activity
M1D19_RS16460	COG1070	Carbohydrate kinase
M1D19_RS16470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1D19_RS16475	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M1D19_RS16485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M1D19_RS16490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M1D19_RS16495	COG0604	alcohol dehydrogenase
M1D19_RS16500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1D19_RS16510	COG0604	alcohol dehydrogenase
M1D19_RS16510	COG3321	synthase
M1D19_RS16515	COG1028	Short-chain dehydrogenase reductase Sdr
M1D19_RS16540	COG0656	L-ascorbic acid biosynthetic process
M1D19_RS16545	COG2814	Major facilitator Superfamily
M1D19_RS16560	COG0346	lactoylglutathione lyase activity
M1D19_RS16565	COG0814	amino acid
M1D19_RS16590	COG1393	Belongs to the ArsC family
M1D19_RS16595	COG1733	regulation of RNA biosynthetic process
M1D19_RS16600	COG2188	Transcriptional regulator
M1D19_RS16610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M1D19_RS16615	COG1733	regulation of RNA biosynthetic process
M1D19_RS16620	COG1733	regulation of RNA biosynthetic process
M1D19_RS16635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1D19_RS16655	COG0384	phenazine biosynthesis protein PhzF
M1D19_RS16665	COG1028	Short-chain dehydrogenase reductase Sdr
M1D19_RS16675	COG0318	PFAM AMP-dependent synthetase and ligase
M1D19_RS16685	COG1733	regulation of RNA biosynthetic process
M1D19_RS16715	COG1191	sigma factor activity
M1D19_RS16730	COG1309	transcriptional regulator
M1D19_RS16750	COG3152	Membrane
M1D19_RS16775	COG1151	hydroxylamine reductase activity
M1D19_RS16785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1D19_RS16790	COG3409	Peptidoglycan-binding domain 1 protein
M1D19_RS16790	COG3757	hydrolase, family 25
M1D19_RS16825	COG2072	flavoprotein involved in K transport
M1D19_RS16865	COG1113	amino acid transport
M1D19_RS16870	COG2814	Major facilitator Superfamily
M1D19_RS16900	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M1D19_RS16905	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M1D19_RS16930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1D19_RS16935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1D19_RS16940	COG3739	integral membrane protein
M1D19_RS16945	COG0384	phenazine biosynthesis protein PhzF
M1D19_RS16975	COG0583	DNA-binding transcription factor activity
M1D19_RS16995	COG1193	negative regulation of DNA recombination
M1D19_RS17020	COG1164	Oligoendopeptidase f
M1D19_RS17025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1D19_RS17055	COG0584	glycerophosphoryl diester phosphodiesterase
M1D19_RS17080	COG0640	Transcriptional regulator
M1D19_RS17085	COG0604	alcohol dehydrogenase
M1D19_RS17105	COG2808	Putative FMN-binding domain
M1D19_RS17110	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1D19_RS17120	COG0385	Bile acid
M1D19_RS17125	COG0277	FAD linked oxidase domain protein
M1D19_RS17155	COG1216	Glycosyl transferase, family 2
M1D19_RS17160	COG1024	Enoyl-CoA hydratase
M1D19_RS17170	COG1285	pathogenesis
M1D19_RS17185	COG2514	catechol 2,3-dioxygenase activity
M1D19_RS17190	COG2720	vancomycin resistance protein
M1D19_RS17230	COG0716	FMN binding
M1D19_RS17260	COG1028	Short-chain dehydrogenase reductase Sdr
M1D19_RS17270	COG0165	Argininosuccinate lyase
M1D19_RS17285	COG4145	pantothenate transmembrane transporter activity
M1D19_RS17295	COG1012	belongs to the aldehyde dehydrogenase family
M1D19_RS17300	COG1028	Short-chain dehydrogenase reductase Sdr
M1D19_RS17310	COG1657	PFAM Prenyltransferase squalene oxidase
M1D19_RS17315	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M1D19_RS17320	COG2962	Rard protein
M1D19_RS17325	COG3326	Membrane
M1D19_RS17340	COG0489	protein tyrosine kinase activity
M1D19_RS17350	COG0314	molybdopterin synthase activity
M1D19_RS17355	COG0303	'Molybdopterin
M1D19_RS17360	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M1D19_RS17365	COG2116	formate transmembrane transporter activity
M1D19_RS17375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1D19_RS17380	COG5609	conserved protein (DUF2294)
M1D19_RS17385	COG2427	Protein of unknown function (DUF1641)
M1D19_RS17390	COG3383	formate dehydrogenase (NAD+) activity
M1D19_RS17400	COG0697	spore germination
M1D19_RS17440	COG2226	methyltransferase
M1D19_RS17445	COG4166	transmembrane transport
M1D19_RS17450	COG4166	transmembrane transport
M1D19_RS17455	COG1301	dicarboxylic acid transport
M1D19_RS17460	COG1316	TRANSCRIPTIONal
M1D19_RS17470	COG1595	DNA-templated transcription, initiation
M1D19_RS17485	COG1131	(ABC) transporter
M1D19_RS17495	COG0673	inositol 2-dehydrogenase activity
M1D19_RS17500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M1D19_RS17505	COG0187	DNA topoisomerase II activity
M1D19_RS17510	COG1832	CoA-binding protein
M1D19_RS17515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1D19_RS17520	COG0745	RESPONSE REGULATOR receiver
M1D19_RS17535	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M1D19_RS17540	COG4841	protein insertion into membrane
M1D19_RS17545	COG0824	Thioesterase
M1D19_RS17575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1D19_RS17585	COG2274	protein secretion by the type I secretion system
M1D19_RS17590	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1D19_RS17630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M1D19_RS17645	COG0183	Belongs to the thiolase family
M1D19_RS17650	COG0318	PFAM AMP-dependent synthetase and ligase
M1D19_RS17655	COG1268	BioY protein
M1D19_RS17660	COG0318	PFAM AMP-dependent synthetase and ligase
M1D19_RS17710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1D19_RS17720	COG5002	protein histidine kinase activity
M1D19_RS17725	COG0400	carboxylic ester hydrolase activity
M1D19_RS17730	COG0346	lactoylglutathione lyase activity
M1D19_RS17735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1D19_RS17740	COG0069	glutamate synthase activity
M1D19_RS17745	COG1902	pentaerythritol trinitrate reductase activity
M1D19_RS17750	COG1329	Transcriptional regulator
M1D19_RS17755	COG0010	Belongs to the arginase family
M1D19_RS17780	COG2226	methyltransferase
M1D19_RS17815	COG4846	Membrane protein involved in cytochrome C biogenesis
M1D19_RS17820	COG0785	Cytochrome C biogenesis protein
M1D19_RS17830	COG0583	DNA-binding transcription factor activity
M1D19_RS17835	COG1380	Effector of murein hydrolase LrgA
M1D19_RS17840	COG1346	cytolysis
M1D19_RS17865	COG5632	N-Acetylmuramoyl-L-alanine amidase
M1D19_RS17865	COG3409	Peptidoglycan-binding domain 1 protein
M1D19_RS17880	COG1132	(ABC) transporter
M1D19_RS17885	COG1132	(ABC) transporter
M1D19_RS17915	COG3639	organic phosphonate transmembrane transporter activity
M1D19_RS17920	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
M1D19_RS17940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1D19_RS17960	COG1695	Transcriptional regulator
M1D19_RS18005	COG3409	Peptidoglycan-binding domain 1 protein
M1D19_RS18005	COG5632	N-Acetylmuramoyl-L-alanine amidase
M1D19_RS18005	COG1388	LysM domain
M1D19_RS18010	COG4824	toxin secretion phage lysis holin
M1D19_RS18170	COG1595	DNA-templated transcription, initiation
M1D19_RS18215	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
M1D19_RS18300	COG1396	sequence-specific DNA binding
M1D19_RS18325	COG0174	glutamine synthetase
M1D19_RS18330	COG0789	Transcriptional regulator
M1D19_RS18335	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M1D19_RS18345	COG2860	membrane
M1D19_RS18350	COG0464	growth
M1D19_RS18380	COG3584	3D domain protein
M1D19_RS18380	COG1388	LysM domain
M1D19_RS18385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1D19_RS18385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1D19_RS18385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1D19_RS18390	COG1105	Belongs to the carbohydrate kinase PfkB family
M1D19_RS18395	COG1349	DNA-binding transcription factor activity
M1D19_RS18405	COG2322	membrane
M1D19_RS18415	COG1113	amino acid transport
M1D19_RS18430	COG1408	metallophosphoesterase
M1D19_RS18435	COG2116	formate transmembrane transporter activity
M1D19_RS18445	COG2217	Heavy metal translocating P-type atpase
M1D19_RS18450	COG2608	mercury ion transmembrane transporter activity
M1D19_RS18455	COG1937	Protein conserved in bacteria
M1D19_RS18465	COG2819	hydrolase of the alpha beta superfamily
M1D19_RS18470	COG1120	ATPase activity
M1D19_RS18475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1D19_RS18480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1D19_RS18485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1D19_RS18490	COG0708	Exodeoxyribonuclease III
M1D19_RS18495	COG2169	Transcriptional regulator
M1D19_RS18500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1D19_RS18505	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M1D19_RS18515	COG2364	Membrane
M1D19_RS18530	COG2267	carboxylic ester hydrolase activity
M1D19_RS18535	COG0346	lactoylglutathione lyase activity
M1D19_RS18540	COG3300	MHYT domain
M1D19_RS18540	COG5001	Diguanylate cyclase
M1D19_RS18560	COG1346	cytolysis
M1D19_RS18565	COG1380	Effector of murein hydrolase LrgA
M1D19_RS18570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1D19_RS18575	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1D19_RS18575	COG0596	Alpha beta hydrolase
M1D19_RS18580	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M1D19_RS18600	COG1404	Belongs to the peptidase S8 family
M1D19_RS18605	COG3773	Cell wall hydrolase
M1D19_RS18610	COG0562	UDP-galactopyranose mutase
M1D19_RS18615	COG1368	sulfuric ester hydrolase activity
M1D19_RS18620	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M1D19_RS18630	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M1D19_RS18655	COG1131	(ABC) transporter
M1D19_RS18675	COG4550	Control of competence regulator ComK, YlbF/YmcA
M1D19_RS18680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M1D19_RS18685	COG1013	pyruvate-flavodoxin oxidoreductase activity
M1D19_RS18690	COG0674	pyruvate-flavodoxin oxidoreductase activity
M1D19_RS18690	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M1D19_RS18700	COG2359	stage V sporulation protein S
M1D19_RS18705	COG1692	metallophosphoesterase
M1D19_RS18730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1D19_RS18735	COG1426	Protein conserved in bacteria
M1D19_RS18750	COG0300	oxidoreductase activity
M1D19_RS18755	COG0612	Peptidase, M16
M1D19_RS18760	COG0612	Peptidase, M16
M1D19_RS18775	COG3845	ABC transporter
M1D19_RS18780	COG1744	ABC transporter substrate-binding protein PnrA-like
M1D19_RS18785	COG2188	Transcriptional regulator
M1D19_RS18790	COG1674	ftsk spoiiie
M1D19_RS18800	COG0740	serine-type endopeptidase activity
M1D19_RS18805	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M1D19_RS18815	COG0527	aspartate kinase activity
M1D19_RS18820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M1D19_RS18825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1D19_RS18830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M1D19_RS18835	COG1873	PFAM PRC-barrel domain
M1D19_RS18840	COG0612	Peptidase, M16
M1D19_RS18845	COG0726	polysaccharide deacetylase
M1D19_RS18860	COG0196	riboflavin kinase activity
M1D19_RS18865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1D19_RS18875	COG1550	Protein conserved in bacteria
M1D19_RS18885	COG1358	cellular component organization or biogenesis
M1D19_RS18890	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M1D19_RS18895	COG0195	Participates in both transcription termination and antitermination
M1D19_RS18915	COG0750	zinc metalloprotease
M1D19_RS18925	COG4589	Belongs to the CDS family
M1D19_RS18930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1D19_RS18940	COG0528	UMP kinase activity
M1D19_RS18970	COG4974	Belongs to the 'phage' integrase family
M1D19_RS18980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M1D19_RS18990	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M1D19_RS19030	COG1837	Belongs to the UPF0109 family
M1D19_RS19040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1D19_RS19050	COG0552	protein localization to endoplasmic reticulum
M1D19_RS19055	COG1196	nuclear chromosome segregation
M1D19_RS19065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1D19_RS19070	COG1028	Short-chain dehydrogenase reductase Sdr
M1D19_RS19075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1D19_RS19090	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1D19_RS19095	COG1461	Dihydroxyacetone kinase
M1D19_RS19100	COG1302	Protein conserved in bacteria
M1D19_RS19115	COG1564	THIamine pyrophosphokinase
M1D19_RS19120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1D19_RS19125	COG1162	GTPase activity
M1D19_RS19130	COG2815	serine threonine protein kinase
M1D19_RS19130	COG0515	serine threonine protein kinase
M1D19_RS19135	COG0631	protein serine/threonine phosphatase activity
M1D19_RS19145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M1D19_RS19145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M1D19_RS19155	COG0242	peptide deformylase activity
M1D19_RS19160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1D19_RS19165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1D19_RS19185	COG1561	YicC-like family, N-terminal region
M1D19_RS19190	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1D19_RS19200	COG0006	proline dipeptidase activity
M1D19_RS19215	COG3069	C4-dicarboxylate transmembrane transporter activity
M1D19_RS19280	COG0564	pseudouridine synthase activity
M1D19_RS19300	COG3599	regulation of cell shape
M1D19_RS19305	COG2302	S4 RNA-binding domain
M1D19_RS19310	COG0762	integral membrane protein
M1D19_RS19320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M1D19_RS19325	COG1496	oxidoreductase activity
M1D19_RS19330	COG1873	PFAM PRC-barrel domain
M1D19_RS19335	COG1191	sigma factor activity
M1D19_RS19340	COG1191	sigma factor activity
M1D19_RS19350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1D19_RS19355	COG0849	cell division
M1D19_RS19360	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1D19_RS19365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M1D19_RS19375	COG0772	Belongs to the SEDS family
M1D19_RS19390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1D19_RS19395	COG0768	penicillin binding
M1D19_RS19400	COG0768	penicillin binding
M1D19_RS19405	COG4839	cell division protein FtsL
M1D19_RS19420	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M1D19_RS19435	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M1D19_RS19440	COG1399	metal-binding, possibly nucleic acid-binding protein
M1D19_RS19490	COG4824	toxin secretion phage lysis holin
M1D19_RS19590	COG1802	Transcriptional regulator
M1D19_RS19590	COG4626	Terminase
M1D19_RS19615	COG0582	viral genome integration into host DNA
M1D19_RS19680	COG0756	dUTP diphosphatase activity
M1D19_RS19695	COG1191	sigma factor activity
M1D19_RS19720	COG1484	DNA-dependent DNA replication
M1D19_RS19750	COG1396	sequence-specific DNA binding
M1D19_RS19765	COG1396	sequence-specific DNA binding
M1D19_RS19785	COG0582	viral genome integration into host DNA
M1D19_RS19795	COG3480	Lon protease (S16) C-terminal proteolytic domain
M1D19_RS19800	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1D19_RS19805	COG3314	Sporulation integral membrane protein YlbJ
M1D19_RS19815	COG0742	ribosomal rna small subunit methyltransferase
M1D19_RS19830	COG3679	Belongs to the UPF0342 family
M1D19_RS19835	COG0406	alpha-ribazole phosphatase activity
M1D19_RS19850	COG2340	Cysteine-rich secretory protein family
M1D19_RS19865	COG3336	cytochrome c oxidase
M1D19_RS19900	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M1D19_RS19905	COG0772	Belongs to the SEDS family
M1D19_RS19915	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M1D19_RS19920	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M1D19_RS19930	COG4896	Protein conserved in bacteria
M1D19_RS19945	COG1217	gtp-binding protein TYPA
M1D19_RS19955	COG0483	inositol monophosphate 1-phosphatase activity
M1D19_RS19975	COG1982	Orn Lys Arg decarboxylase major
M1D19_RS20020	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1D19_RS20025	COG0022	dehydrogenase e1 component
M1D19_RS20030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1D19_RS20040	COG0242	peptide deformylase activity
M1D19_RS20045	COG0561	phosphatase activity
M1D19_RS20055	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M1D19_RS20060	COG0569	domain protein
M1D19_RS20080	COG0583	DNA-binding transcription factor activity
M1D19_RS20085	COG0517	IMP dehydrogenase activity
M1D19_RS20095	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
M1D19_RS20105	COG4703	Protein of unknown function (DUF1797)
M1D19_RS20120	COG2200	EAL domain
M1D19_RS20125	COG1028	Short-chain dehydrogenase reductase Sdr
M1D19_RS20130	COG1408	metallophosphoesterase
M1D19_RS20140	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M1D19_RS20175	COG2814	Major facilitator Superfamily
M1D19_RS20195	COG3209	COG3209 Rhs family protein
M1D19_RS20205	COG2205	protein histidine kinase activity
M1D19_RS20215	COG0436	Aminotransferase
M1D19_RS20220	COG1609	Transcriptional regulator
M1D19_RS20225	COG3833	ABC-type maltose transport systems, permease component
M1D19_RS20230	COG1175	transmembrane transport
M1D19_RS20235	COG2182	Extracellular solute-binding protein
M1D19_RS20245	COG0366	Alpha amylase catalytic
M1D19_RS20250	COG3842	ATPase activity
M1D19_RS20290	COG0183	Belongs to the thiolase family
M1D19_RS20325	COG1695	Transcriptional regulator
M1D19_RS20330	COG1028	Short-chain dehydrogenase reductase Sdr
M1D19_RS20340	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M1D19_RS20350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1D19_RS20355	COG0436	Aminotransferase
M1D19_RS20375	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M1D19_RS20395	COG2199	diguanylate cyclase activity
M1D19_RS20400	COG0778	Nitroreductase
M1D19_RS20425	COG1263	PTS System
M1D19_RS20425	COG2190	(PTS) system
M1D19_RS20425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1D19_RS20430	COG3711	transcriptional antiterminator
M1D19_RS20440	COG2188	Transcriptional regulator
M1D19_RS20450	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M1D19_RS20475	COG1547	Domain of unknown function (DUF309)
M1D19_RS20480	COG0456	acetyltransferase
M1D19_RS20490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1D19_RS20495	COG4086	secreted protein
M1D19_RS20500	COG0561	phosphatase activity
M1D19_RS20505	COG0697	spore germination
M1D19_RS20520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M1D19_RS20545	COG0733	neurotransmitter:sodium symporter activity
M1D19_RS20565	COG1686	Belongs to the peptidase S11 family
M1D19_RS20570	COG1725	Transcriptional regulator
M1D19_RS20575	COG1131	(ABC) transporter
M1D19_RS20590	COG1846	Transcriptional regulator
M1D19_RS20605	COG0598	Magnesium transport protein CorA
M1D19_RS20630	COG4974	Belongs to the 'phage' integrase family
M1D19_RS20640	COG0735	belongs to the Fur family
M1D19_RS20645	COG1300	Membrane
M1D19_RS20665	COG0667	Aldo Keto reductase
M1D19_RS20670	COG0656	L-ascorbic acid biosynthetic process
M1D19_RS20675	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1D19_RS20675	COG0456	acetyltransferase
M1D19_RS20685	COG1525	nuclease
M1D19_RS20685	COG4085	toxin activity
M1D19_RS20685	COG0737	Belongs to the 5'-nucleotidase family
M1D19_RS20695	COG0596	Alpha beta hydrolase
M1D19_RS20700	COG2056	Na+-H+ antiporter family
M1D19_RS20705	COG1609	Transcriptional regulator
M1D19_RS20710	COG0456	acetyltransferase
M1D19_RS20715	COG1073	alpha beta
M1D19_RS20730	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1D19_RS20730	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1D19_RS20735	COG0307	riboflavin synthase, alpha
M1D19_RS20760	COG4106	trans-aconitate 2-methyltransferase activity
M1D19_RS20765	COG2226	methyltransferase
M1D19_RS20765	COG1073	alpha beta
M1D19_RS20780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M1D19_RS20790	COG1757	Na H antiporter
M1D19_RS20795	COG0737	Belongs to the 5'-nucleotidase family
M1D19_RS20805	COG1522	sequence-specific DNA binding
M1D19_RS20825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1D19_RS20835	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M1D19_RS20850	COG0300	oxidoreductase activity
M1D19_RS20860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M1D19_RS20865	COG1760	l-serine dehydratase
M1D19_RS20870	COG1760	l-serine dehydratase
M1D19_RS20890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1D19_RS20900	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1D19_RS20905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1D19_RS20920	COG1376	ErfK ybiS ycfS ynhG family protein
M1D19_RS20925	COG4129	membrane
M1D19_RS20930	COG1126	abc transporter atp-binding protein
M1D19_RS20935	COG0765	amino acid transport
M1D19_RS20940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1D19_RS20955	COG2816	NAD+ diphosphatase activity
M1D19_RS20960	COG0772	Belongs to the SEDS family
M1D19_RS20965	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1D19_RS20970	COG0022	dehydrogenase e1 component
M1D19_RS20975	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1D19_RS20980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1D19_RS20995	COG0280	phosphate acetyltransferase
M1D19_RS21000	COG3829	transcription factor binding
M1D19_RS21000	COG3290	protein histidine kinase activity
M1D19_RS21010	COG0584	glycerophosphoryl diester phosphodiesterase
M1D19_RS21015	COG3093	addiction module antidote protein HigA
M1D19_RS21025	COG0745	RESPONSE REGULATOR receiver
M1D19_RS21030	COG0750	zinc metalloprotease
M1D19_RS21035	COG0497	DNA recombination
M1D19_RS21045	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M1D19_RS21055	COG0142	geranyltranstransferase activity
M1D19_RS21080	COG1302	Protein conserved in bacteria
M1D19_RS21085	COG0439	Biotin carboxylase
M1D19_RS21090	COG0511	ligase activity, forming carbon-carbon bonds
M1D19_RS21135	COG3854	ATPases associated with a variety of cellular activities
M1D19_RS21160	COG0006	proline dipeptidase activity
M1D19_RS21175	COG3872	metal-dependent enzyme
M1D19_RS21185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1D19_RS21205	COG0095	Lipoate-protein ligase
M1D19_RS21210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M1D19_RS21215	COG1609	Transcriptional regulator
M1D19_RS21225	COG2076	Multidrug Resistance protein
M1D19_RS21230	COG2076	Multidrug Resistance protein
M1D19_RS21265	COG1131	(ABC) transporter
M1D19_RS21270	COG1725	Transcriptional regulator
M1D19_RS21300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M1D19_RS21360	COG4970	Tfp pilus assembly protein FimT
M1D19_RS21370	COG1459	type II secretion system
M1D19_RS21375	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1D19_RS21425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M1D19_RS21430	COG0646	methionine synthase
M1D19_RS21430	COG1410	methionine synthase
M1D19_RS21435	COG0646	methionine synthase
M1D19_RS21435	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1D19_RS21440	COG0626	cystathionine gamma-synthase activity
M1D19_RS21445	COG0626	cystathionine gamma-synthase activity
M1D19_RS21465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1D19_RS21475	COG1940	carbohydrate kinase activity
M1D19_RS21480	COG4483	Protein conserved in bacteria
M1D19_RS21485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1D19_RS21490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M1D19_RS21495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1D19_RS21500	COG0704	Plays a role in the regulation of phosphate uptake
M1D19_RS21510	COG0581	inorganic phosphate transmembrane transporter activity
M1D19_RS21515	COG0573	inorganic phosphate transmembrane transporter activity
M1D19_RS21520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1D19_RS21525	COG0768	penicillin binding
M1D19_RS21530	COG0477	Major facilitator Superfamily
M1D19_RS21535	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1D19_RS21560	COG0735	belongs to the Fur family
M1D19_RS21565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1D19_RS21570	COG1121	(ABC) transporter
M1D19_RS21575	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1D19_RS21605	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1D19_RS21610	COG2384	SAM-dependent methyltransferase
M1D19_RS21615	COG2010	Cytochrome c
M1D19_RS21620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M1D19_RS21625	COG0358	DNA primase activity
M1D19_RS21640	COG0517	IMP dehydrogenase activity
M1D19_RS21655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1D19_RS21660	COG0295	cytidine deaminase activity
M1D19_RS21665	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M1D19_RS21675	COG1480	7TM receptor with intracellular HD hydrolase
M1D19_RS21680	COG1702	phosphate starvation-inducible protein PhoH
M1D19_RS21695	COG1610	YqeY-like protein
M1D19_RS21700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M1D19_RS21705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M1D19_RS21710	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1D19_RS21740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1D19_RS21745	COG1733	regulation of RNA biosynthetic process
M1D19_RS21770	COG1466	dna polymerase III delta subunit
M1D19_RS21780	COG0658	competence protein
M1D19_RS21780	COG2333	competence protein COMEC
M1D19_RS21785	COG2131	deaminase
M1D19_RS21790	COG1555	photosystem II stabilization
M1D19_RS21790	COG1596	polysaccharide export
M1D19_RS21795	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M1D19_RS21800	COG2226	methyltransferase
M1D19_RS21805	COG0799	negative regulation of ribosome biogenesis
M1D19_RS21810	COG1713	HD superfamily hydrolase involved in NAD metabolism
M1D19_RS21820	COG1534	Rna-binding protein
M1D19_RS21830	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M1D19_RS21835	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M1D19_RS21860	COG1595	DNA-templated transcription, initiation
M1D19_RS21870	COG0778	Nitroreductase
M1D19_RS21875	COG2357	RelA SpoT domain protein
M1D19_RS21885	COG1785	Belongs to the alkaline phosphatase family
M1D19_RS21895	COG2267	carboxylic ester hydrolase activity
M1D19_RS21930	COG1404	Belongs to the peptidase S8 family
M1D19_RS21935	COG3186	Phenylalanine-4-hydroxylase
M1D19_RS21950	COG2259	Doxx family
M1D19_RS21990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1D19_RS22000	COG1012	belongs to the aldehyde dehydrogenase family
M1D19_RS22000	COG1454	alcohol dehydrogenase
M1D19_RS22005	COG0626	cystathionine gamma-synthase activity
M1D19_RS22010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1D19_RS22035	COG0768	penicillin binding
M1D19_RS22050	COG0826	peptidase U32
M1D19_RS22055	COG0826	peptidase U32
M1D19_RS22060	COG4122	O-methyltransferase activity
M1D19_RS22065	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1D19_RS22085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M1D19_RS22095	COG0628	permease
M1D19_RS22115	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1D19_RS22125	COG0482	sulfurtransferase activity
M1D19_RS22130	COG1104	cysteine desulfurase activity
M1D19_RS22135	COG1959	2 iron, 2 sulfur cluster binding
M1D19_RS22140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1D19_RS22150	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1D19_RS22175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1D19_RS22185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1D19_RS22185	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M1D19_RS22190	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M1D19_RS22195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1D19_RS22195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1D19_RS22205	COG2244	polysaccharide biosynthetic process
M1D19_RS22210	COG2323	membrane
M1D19_RS22220	COG1862	Preprotein translocase
M1D19_RS22250	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M1D19_RS22260	COG0697	spore germination
M1D19_RS22265	COG0697	spore germination
M1D19_RS22270	COG0640	Transcriptional regulator
M1D19_RS22295	COG0157	Belongs to the NadC ModD family
M1D19_RS22300	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M1D19_RS22305	COG1104	cysteine desulfurase activity
M1D19_RS22310	COG1827	regulation of RNA biosynthetic process
M1D19_RS22315	COG2258	MOSC domain
M1D19_RS22320	COG0077	Prephenate dehydratase
M1D19_RS22325	COG0577	efflux transmembrane transporter activity
M1D19_RS22330	COG0577	efflux transmembrane transporter activity
M1D19_RS22335	COG1136	(ABC) transporter
M1D19_RS22345	COG0745	RESPONSE REGULATOR receiver
M1D19_RS22350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M1D19_RS22355	COG3290	protein histidine kinase activity
M1D19_RS22365	COG2868	ribosomal protein
M1D19_RS22375	COG1530	ribonuclease E activity
M1D19_RS22380	COG1994	Peptidase M50
M1D19_RS22385	COG0739	heme binding
M1D19_RS22390	COG2894	cell division
M1D19_RS22410	COG1077	Cell shape determining protein MreB Mrl
M1D19_RS22430	COG0285	dihydrofolate synthase activity
M1D19_RS22435	COG0525	valine-tRNA ligase activity
M1D19_RS22445	COG1388	LysM domain
M1D19_RS22455	COG0113	porphobilinogen synthase activity
M1D19_RS22460	COG1587	Uroporphyrinogen-III synthase
M1D19_RS22470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M1D19_RS22480	COG1846	Transcriptional regulator
M1D19_RS22485	COG1764	response to oxidative stress
M1D19_RS22500	COG0470	DNA polymerase III
M1D19_RS22500	COG1067	ATP-dependent peptidase activity
M1D19_RS22545	COG0622	Phosphoesterase
M1D19_RS22560	COG5401	PFAM Sporulation and spore germination
M1D19_RS22580	COG1309	transcriptional regulator
M1D19_RS22595	COG2197	response regulator
M1D19_RS22600	COG2233	PERMEase
M1D19_RS22610	COG0402	S-adenosylhomocysteine deaminase activity
M1D19_RS22615	COG0402	S-adenosylhomocysteine deaminase activity
M1D19_RS22625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1D19_RS22635	COG0444	Belongs to the ABC transporter superfamily
M1D19_RS22640	COG4608	Belongs to the ABC transporter superfamily
M1D19_RS22645	COG3275	phosphorelay sensor kinase activity
M1D19_RS22650	COG3279	Response regulator of the LytR AlgR family
M1D19_RS22665	COG1983	PspC domain protein
M1D19_RS22670	COG1396	sequence-specific DNA binding
M1D19_RS22675	COG0697	spore germination
M1D19_RS22685	COG1959	2 iron, 2 sulfur cluster binding
M1D19_RS22690	COG1668	transmembrane transport
M1D19_RS22695	COG4152	abc transporter atp-binding protein
M1D19_RS22700	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M1D19_RS22710	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M1D19_RS22715	COG1876	peptidase activity
M1D19_RS22720	COG0824	Thioesterase
M1D19_RS22725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1D19_RS22730	COG1053	succinate dehydrogenase
M1D19_RS22735	COG2009	succinate dehydrogenase
M1D19_RS22740	COG1719	4-vinyl reductase, 4VR
M1D19_RS22750	COG3118	belongs to the thioredoxin family
M1D19_RS22755	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M1D19_RS22760	COG2086	electron transfer activity
M1D19_RS22765	COG1024	Enoyl-CoA hydratase
M1D19_RS22775	COG0318	PFAM AMP-dependent synthetase and ligase
M1D19_RS22795	COG2318	DinB family
M1D19_RS22825	COG1131	(ABC) transporter
M1D19_RS22830	COG2205	protein histidine kinase activity
M1D19_RS22835	COG0745	RESPONSE REGULATOR receiver
M1D19_RS22845	COG4895	conserved protein (DUF2196)
M1D19_RS22850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M1D19_RS22865	COG4509	Sortase family
M1D19_RS22870	COG1120	ATPase activity
M1D19_RS22885	COG5386	Cell surface protein
M1D19_RS22895	COG5386	Cell surface protein
M1D19_RS22900	COG1114	Component of the transport system for branched-chain amino acids
M1D19_RS22905	COG1187	pseudouridine synthase activity
M1D19_RS22915	COG1796	DNA polymerase
M1D19_RS22915	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M1D19_RS22920	COG1286	toxin biosynthetic process
M1D19_RS22965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1D19_RS22975	COG1418	mRNA catabolic process
M1D19_RS23000	COG2814	Major facilitator Superfamily
M1D19_RS23005	COG1566	PFAM secretion protein HlyD family protein
M1D19_RS23010	COG1309	transcriptional regulator
M1D19_RS23015	COG1363	Peptidase, m42
M1D19_RS23040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M1D19_RS23050	COG1484	DNA-dependent DNA replication
M1D19_RS23055	COG3611	Membrane attachment protein
M1D19_RS23065	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M1D19_RS23070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1D19_RS23075	COG0237	dephospho-CoA kinase activity
M1D19_RS23080	COG1971	Probably functions as a manganese efflux pump
M1D19_RS23090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1D19_RS23090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1D19_RS23095	COG5002	protein histidine kinase activity
M1D19_RS23100	COG0745	RESPONSE REGULATOR receiver
M1D19_RS23125	COG0538	isocitrate dehydrogenase activity
M1D19_RS23130	COG0372	Belongs to the citrate synthase family
M1D19_RS23140	COG0628	permease
M1D19_RS23145	COG3030	protein affecting phage T7 exclusion by the F plasmid
M1D19_RS23170	COG1725	Transcriptional regulator
M1D19_RS23175	COG0281	malic enzyme
M1D19_RS23180	COG0587	DNA-directed DNA polymerase activity
M1D19_RS23195	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M1D19_RS23215	COG4109	DRTGG domain
M1D19_RS23230	COG0006	proline dipeptidase activity
M1D19_RS23270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1D19_RS23275	COG0662	Cupin 2, conserved barrel domain protein
M1D19_RS23285	COG1476	TRANSCRIPTIONal
M1D19_RS23300	COG1028	Short-chain dehydrogenase reductase Sdr
M1D19_RS23305	COG0589	response to stress
M1D19_RS23345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1D19_RS23365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1D19_RS23370	COG0827	DNA restriction-modification system
M1D19_RS23375	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M1D19_RS23380	COG3874	Sporulation protein YtfJ
M1D19_RS23395	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M1D19_RS23405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1D19_RS23420	COG1104	cysteine desulfurase activity
M1D19_RS23430	COG0583	DNA-binding transcription factor activity
M1D19_RS23435	COG0697	spore germination
M1D19_RS23445	COG1956	GAF domain-containing protein
M1D19_RS23450	COG0626	cystathionine gamma-synthase activity
M1D19_RS23480	COG1595	DNA-templated transcription, initiation
M1D19_RS23490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1D19_RS23495	COG0454	-acetyltransferase
M1D19_RS23500	COG0517	IMP dehydrogenase activity
M1D19_RS23505	COG0123	including yeast histone deacetylase and acetoin utilization protein
M1D19_RS23515	COG0745	RESPONSE REGULATOR receiver
M1D19_RS23525	COG0666	response to abiotic stimulus
M1D19_RS23560	COG1609	Transcriptional regulator
M1D19_RS23565	COG4851	CamS sex pheromone cAM373 precursor
M1D19_RS23570	COG3118	belongs to the thioredoxin family
M1D19_RS23580	COG2309	aminopeptidase activity
M1D19_RS23600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1D19_RS23615	COG1674	ftsk spoiiie
M1D19_RS23625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1D19_RS23630	COG4848	Belongs to the UPF0354 family
M1D19_RS23635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1D19_RS23640	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
M1D19_RS23645	COG1363	Peptidase, m42
M1D19_RS23655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1D19_RS23670	COG0510	thiamine kinase activity
M1D19_RS23675	COG1523	belongs to the glycosyl hydrolase 13 family
M1D19_RS23690	COG1349	DNA-binding transcription factor activity
M1D19_RS23695	COG1187	pseudouridine synthase activity
M1D19_RS23700	COG2244	polysaccharide biosynthetic process
M1D19_RS23705	COG2081	HI0933 family
M1D19_RS23710	COG2814	Major facilitator Superfamily
M1D19_RS23720	COG3832	glyoxalase III activity
M1D19_RS23740	COG1329	Transcriptional regulator
M1D19_RS23750	COG4975	Glucose uptake
M1D19_RS23765	COG0314	molybdopterin synthase activity
M1D19_RS23770	COG1763	Mo-molybdopterin cofactor biosynthetic process
M1D19_RS23775	COG0303	'Molybdopterin
M1D19_RS23785	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M1D19_RS23810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M1D19_RS23820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1D19_RS23865	COG2814	Major facilitator Superfamily
M1D19_RS23870	COG0475	glutathione-regulated potassium exporter activity
M1D19_RS23875	COG0490	domain, Protein
M1D19_RS23880	COG0582	viral genome integration into host DNA
M1D19_RS23890	COG1136	(ABC) transporter
M1D19_RS23910	COG1242	4 iron, 4 sulfur cluster binding
M1D19_RS23915	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M1D19_RS23920	COG1131	(ABC) transporter
M1D19_RS23930	COG1794	racemase activity, acting on amino acids and derivatives
M1D19_RS23950	COG2267	carboxylic ester hydrolase activity
M1D19_RS23955	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1D19_RS23960	COG0671	phosphoesterase, PA-phosphatase related
M1D19_RS23965	COG0438	transferase activity, transferring glycosyl groups
M1D19_RS23975	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1D19_RS24030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1D19_RS24035	COG5002	protein histidine kinase activity
M1D19_RS24040	COG4191	Histidine kinase
M1D19_RS24045	COG2267	carboxylic ester hydrolase activity
M1D19_RS24065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1D19_RS24070	COG1116	anion transmembrane transporter activity
M1D19_RS24075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1D19_RS24100	COG0494	nUDIX hydrolase
M1D19_RS24135	COG0288	reversible hydration of carbon dioxide
M1D19_RS24140	COG1271	oxidase subunit
M1D19_RS24145	COG1294	oxidase, subunit
M1D19_RS24165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1D19_RS24190	COG1842	Phage shock protein A
M1D19_RS24220	COG5002	protein histidine kinase activity
M1D19_RS24225	COG0745	RESPONSE REGULATOR receiver
M1D19_RS24255	COG1597	lipid kinase activity
M1D19_RS24290	COG0586	Pfam SNARE associated Golgi protein
M1D19_RS24300	COG0577	efflux transmembrane transporter activity
M1D19_RS24305	COG1136	(ABC) transporter
M1D19_RS24310	COG2207	Transcriptional regulator
M1D19_RS24310	COG3708	Transcriptional regulator
M1D19_RS24315	COG0745	RESPONSE REGULATOR receiver
M1D19_RS24320	COG2205	protein histidine kinase activity
M1D19_RS24330	COG0577	efflux transmembrane transporter activity
M1D19_RS24335	COG1136	(ABC) transporter
M1D19_RS24355	COG2188	Transcriptional regulator
M1D19_RS24375	COG3964	amidohydrolase
M1D19_RS24405	COG4948	Mandelate Racemase Muconate Lactonizing
M1D19_RS24415	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M1D19_RS24420	COG0596	Alpha beta hydrolase
M1D19_RS24425	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M1D19_RS24430	COG1169	isochorismate synthase
M1D19_RS24435	COG1575	Belongs to the MenA family. Type 1 subfamily
M1D19_RS24440	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1D19_RS24465	COG0058	SHG alpha-glucan phosphorylase activity
M1D19_RS24470	COG0297	glycogen (starch) synthase activity
M1D19_RS24475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M1D19_RS24590	COG0544	peptidyl-prolyl cis-trans isomerase activity
M1D19_RS24625	COG1285	pathogenesis
M1D19_RS24630	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1D19_RS24640	COG0166	Belongs to the GPI family
M1D19_RS24645	COG2155	Conserved Protein
M1D19_RS24650	COG1098	S1 RNA binding domain
M1D19_RS24655	COG0436	Aminotransferase
M1D19_RS24660	COG1522	sequence-specific DNA binding
M1D19_RS24665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M1D19_RS24670	COG2267	carboxylic ester hydrolase activity
M1D19_RS24680	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M1D19_RS24700	COG5018	Exonuclease
M1D19_RS24705	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M1D19_RS24725	COG2050	protein possibly involved in aromatic compounds catabolism
M1D19_RS24735	COG1268	BioY protein
M1D19_RS24745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1D19_RS24750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1D19_RS24765	COG3584	3D domain protein
M1D19_RS24780	COG1252	NADH dehydrogenase
M1D19_RS24795	COG3708	Transcriptional regulator
M1D19_RS24810	COG1683	Conserved Protein
M1D19_RS24830	COG0316	Belongs to the HesB IscA family
M1D19_RS24845	COG1252	NADH dehydrogenase
M1D19_RS24860	COG0390	transport system, permease component
M1D19_RS24865	COG2824	Alkylphosphonate utilization operon protein PhnA
M1D19_RS24905	COG4837	Protein of unknown function (DUF1462)
M1D19_RS24910	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M1D19_RS24920	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1D19_RS24925	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1D19_RS24935	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1D19_RS24940	COG0647	UMP catabolic process
M1D19_RS24950	COG2445	Protein of unknown function DUF86
M1D19_RS24955	COG1494	fructose-1,6-bisphosphatase
M1D19_RS24970	COG4470	Protein conserved in bacteria
M1D19_RS24980	COG0789	Transcriptional regulator
M1D19_RS24985	COG4377	Putative membrane peptidase family (DUF2324)
M1D19_RS25010	COG0739	heme binding
M1D19_RS25020	COG3377	Domain of unknown function (DUF1805)
M1D19_RS25025	COG0737	Belongs to the 5'-nucleotidase family
M1D19_RS25030	COG1695	Transcriptional regulator
M1D19_RS25040	COG0719	Fe-S assembly protein
M1D19_RS25045	COG0822	iron-sulfur transferase activity
M1D19_RS25050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1D19_RS25055	COG0719	Fe-S assembly protein
M1D19_RS25060	COG0396	ATPase activity
M1D19_RS25065	COG1464	Belongs to the NlpA lipoprotein family
M1D19_RS25070	COG1464	Belongs to the NlpA lipoprotein family
M1D19_RS25075	COG2011	ABC-type metal ion transport system permease component
M1D19_RS25080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1D19_RS25090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1D19_RS25095	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M1D19_RS25105	COG1393	Belongs to the ArsC family
M1D19_RS25150	COG0039	L-malate dehydrogenase activity
M1D19_RS25175	COG1309	transcriptional regulator
M1D19_RS25180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1D19_RS25185	COG1960	acyl-CoA dehydrogenase activity
M1D19_RS25190	COG0183	Belongs to the thiolase family
M1D19_RS25195	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1D19_RS25195	COG1024	Enoyl-CoA hydratase
M1D19_RS25205	COG1686	Belongs to the peptidase S11 family
M1D19_RS25220	COG0011	TIGRFAM Protein of
M1D19_RS25225	COG0840	transmembrane signaling receptor activity
M1D19_RS25245	COG2814	Major facilitator Superfamily
M1D19_RS25250	COG0531	amino acid
M1D19_RS25260	COG0706	membrane insertase activity
M1D19_RS25270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1D19_RS25305	COG0586	Pfam SNARE associated Golgi protein
M1D19_RS25315	COG1376	ErfK ybiS ycfS ynhG family protein
M1D19_RS25320	COG0745	RESPONSE REGULATOR receiver
M1D19_RS25325	COG5002	protein histidine kinase activity
M1D19_RS25350	COG2151	metal-sulfur cluster biosynthetic enzyme
M1D19_RS25355	COG3227	Zinc metalloprotease (Elastase)
M1D19_RS25360	COG1741	Belongs to the pirin family
M1D19_RS25375	COG0475	glutathione-regulated potassium exporter activity
M1D19_RS25380	COG0490	domain, Protein
M1D19_RS25385	COG1115	amino acid carrier protein
M1D19_RS25390	COG0783	Belongs to the Dps family
M1D19_RS25405	COG1611	Belongs to the LOG family
M1D19_RS25425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M1D19_RS25430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M1D19_RS25435	COG1115	amino acid carrier protein
M1D19_RS25440	COG1115	amino acid carrier protein
M1D19_RS25445	COG2910	NAD(P)H-binding
M1D19_RS25460	COG0656	L-ascorbic acid biosynthetic process
M1D19_RS25465	COG2814	Major facilitator Superfamily
M1D19_RS25470	COG1733	regulation of RNA biosynthetic process
M1D19_RS25480	COG1252	NADH dehydrogenase
M1D19_RS25485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1D19_RS25490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M1D19_RS25500	COG0840	transmembrane signaling receptor activity
M1D19_RS25500	COG3290	protein histidine kinase activity
M1D19_RS25510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M1D19_RS25515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M1D19_RS25530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1D19_RS25585	COG0557	exoribonuclease II activity
M1D19_RS25590	COG1647	Serine aminopeptidase, S33
M1D19_RS25595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M1D19_RS25600	COG1346	cytolysis
M1D19_RS25710	COG4695	Portal protein
M1D19_RS25735	COG4974	Belongs to the 'phage' integrase family
M1D19_RS25745	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1D19_RS25750	COG0149	triose-phosphate isomerase activity
M1D19_RS25760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1D19_RS25775	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M1D19_RS25800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M1D19_RS25815	COG2323	membrane
M1D19_RS25820	COG0740	serine-type endopeptidase activity
M1D19_RS25825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1D19_RS25835	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M1D19_RS25845	COG1051	belongs to the nudix hydrolase family
M1D19_RS25855	COG0492	ferredoxin-NADP+ reductase activity
M1D19_RS25860	COG0457	Tetratricopeptide repeat
M1D19_RS25865	COG0110	maltose O-acetyltransferase activity
M1D19_RS25885	COG1950	PFAM Membrane protein of
M1D19_RS25895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1D19_RS25900	COG0556	nucleotide-excision repair
M1D19_RS25920	COG0789	Transcriptional regulator
M1D19_RS25945	COG2855	membrane
M1D19_RS25950	COG0583	DNA-binding transcription factor activity
M1D19_RS25960	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1D19_RS25965	COG0488	(ABC) transporter
M1D19_RS25975	COG1132	(ABC) transporter
M1D19_RS25980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1D19_RS25985	COG0793	Belongs to the peptidase S41A family
M1D19_RS25985	COG3409	Peptidoglycan-binding domain 1 protein
M1D19_RS25990	COG2177	Part of the ABC transporter FtsEX involved in
M1D19_RS25995	COG2884	Cell division ATP-binding protein ftsE
M1D19_RS26010	COG0653	protein targeting
M1D19_RS26015	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M1D19_RS26020	COG1278	Cold shock
M1D19_RS26025	COG1040	competence protein
M1D19_RS26030	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M1D19_RS26035	COG0791	NLP P60 protein
M1D19_RS26035	COG1388	LysM domain
M1D19_RS26040	COG1733	regulation of RNA biosynthetic process
M1D19_RS26045	COG1307	EDD domain protein, DegV family
M1D19_RS26050	COG1739	Uncharacterized protein family UPF0029
M1D19_RS26055	COG1316	TRANSCRIPTIONal
M1D19_RS26060	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M1D19_RS26065	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M1D19_RS26070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M1D19_RS26080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M1D19_RS26080	COG3933	PFAM sigma-54 factor interaction domain-containing protein
M1D19_RS26095	COG3394	polysaccharide catabolic process
M1D19_RS26100	COG1486	melibiose metabolic process
M1D19_RS26105	COG1447	Phosphotransferase system cellobiose-specific component IIA
M1D19_RS26110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M1D19_RS26120	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M1D19_RS26125	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M1D19_RS26130	COG1447	Phosphotransferase system cellobiose-specific component IIA
M1D19_RS26140	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M1D19_RS26145	COG1301	dicarboxylic acid transport
M1D19_RS26155	COG0346	lactoylglutathione lyase activity
M1D19_RS26160	COG1511	domain protein
M1D19_RS26165	COG0583	DNA-binding transcription factor activity
M1D19_RS26170	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M1D19_RS26185	COG1271	oxidase subunit
M1D19_RS26190	COG1294	oxidase, subunit
M1D19_RS26195	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M1D19_RS26205	COG1620	l-lactate permease
M1D19_RS26215	COG2389	metal-binding protein
M1D19_RS26225	COG1368	sulfuric ester hydrolase activity
M1D19_RS26240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M1D19_RS26260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1D19_RS26265	COG1388	LysM domain
M1D19_RS26265	COG3584	3D domain protein
M1D19_RS26290	COG4715	Zinc finger, swim domain protein
M1D19_RS26295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M1D19_RS26335	COG0577	efflux transmembrane transporter activity
M1D19_RS26340	COG1136	(ABC) transporter
M1D19_RS26375	COG5002	protein histidine kinase activity
M1D19_RS26380	COG0745	RESPONSE REGULATOR receiver
M1D19_RS26385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1D19_RS26405	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M1D19_RS26410	COG1134	teichoic acid transport
M1D19_RS26415	COG1682	transport, permease protein
M1D19_RS26420	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M1D19_RS26465	COG1609	Transcriptional regulator
M1D19_RS26480	COG0739	heme binding
M1D19_RS26500	COG2385	sporulation resulting in formation of a cellular spore
M1D19_RS26515	COG4836	Membrane
M1D19_RS26520	COG1007	ATP synthesis coupled electron transport
M1D19_RS26525	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1D19_RS26530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1D19_RS26540	COG0839	Belongs to the complex I subunit 6 family
M1D19_RS26555	COG0649	NAD binding
M1D19_RS26560	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1D19_RS26575	COG5001	Diguanylate cyclase
M1D19_RS26575	COG3300	MHYT domain
M1D19_RS26625	COG0356	it plays a direct role in the translocation of protons across the membrane
M1D19_RS26660	COG0698	ribose 5-phosphate isomerase
M1D19_RS26670	COG2190	(PTS) system
M1D19_RS26675	COG2259	Doxx family
M1D19_RS26680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1D19_RS26695	COG0009	L-threonylcarbamoyladenylate synthase
M1D19_RS26710	COG2890	protein-(glutamine-N5) methyltransferase activity
M1D19_RS26730	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M1D19_RS26735	COG1494	fructose-1,6-bisphosphatase
M1D19_RS26755	COG4821	SIS domain
M1D19_RS26765	COG3343	RNA polymerase activity
M1D19_RS26775	COG1960	acyl-CoA dehydrogenase activity
M1D19_RS26780	COG1960	acyl-CoA dehydrogenase activity
M1D19_RS26785	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1D19_RS26790	COG0183	Belongs to the thiolase family
M1D19_RS26795	COG0247	lactate metabolic process
M1D19_RS26795	COG2181	nitrate reductase activity
M1D19_RS26800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1D19_RS26810	COG5001	Diguanylate cyclase
M1D19_RS26810	COG3300	MHYT domain
M1D19_RS26830	COG2197	response regulator
M1D19_RS26835	COG4585	Histidine kinase
M1D19_RS26840	COG0842	Transport permease protein
M1D19_RS26845	COG1131	(ABC) transporter
M1D19_RS26850	COG0024	Methionine aminopeptidase
M1D19_RS26860	COG2234	aminopeptidase activity
M1D19_RS26880	COG1595	DNA-templated transcription, initiation
M1D19_RS26885	COG0018	arginyl-trna synthetase
M1D19_RS26890	COG4506	Protein conserved in bacteria
M1D19_RS26895	COG1619	proteins homologs of microcin C7 resistance protein MccF
M1D19_RS26910	COG0010	Belongs to the arginase family
M1D19_RS26920	COG2814	Major facilitator Superfamily
M1D19_RS26925	COG0789	Transcriptional regulator
M1D19_RS26930	COG0584	glycerophosphoryl diester phosphodiesterase
M1D19_RS26935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1D19_RS26945	COG1994	Peptidase M50
M1D19_RS26955	COG1078	dGTPase activity
M1D19_RS26960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1D19_RS26965	COG1120	ATPase activity
M1D19_RS26970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1D19_RS26995	COG0095	Lipoate-protein ligase
M1D19_RS27000	COG0280	phosphate acetyltransferase
M1D19_RS27015	COG3773	Cell wall hydrolase
M1D19_RS27025	COG2363	Small membrane protein
M1D19_RS27040	COG2233	PERMEase
M1D19_RS27045	COG0561	phosphatase activity
M1D19_RS27050	COG2814	Major facilitator Superfamily
M1D19_RS27060	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M1D19_RS27065	COG1131	(ABC) transporter
M1D19_RS27070	COG2755	lipolytic protein G-D-S-L family
M1D19_RS27075	COG1609	Transcriptional regulator
M1D19_RS27085	COG0460	homoserine dehydrogenase
M1D19_RS27095	COG2873	o-acetylhomoserine
M1D19_RS27105	COG1011	Hydrolase
M1D19_RS27110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1D19_RS27120	COG2197	response regulator
M1D19_RS27130	COG0351	phosphomethylpyrimidine kinase
M1D19_RS27135	COG3706	GGDEF domain
M1D19_RS27140	COG2879	small protein
M1D19_RS27145	COG1966	Carbon starvation protein
M1D19_RS27150	COG3279	Response regulator of the LytR AlgR family
M1D19_RS27155	COG0477	Major facilitator Superfamily
M1D19_RS27180	COG0840	transmembrane signaling receptor activity
M1D19_RS27190	COG1607	acyl-coa hydrolase
M1D19_RS27205	COG0488	(ABC) transporter
M1D19_RS27225	COG0463	Glycosyl transferase, family 2
M1D19_RS27230	COG1309	transcriptional regulator
M1D19_RS27235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1D19_RS27240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M1D19_RS27240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M1D19_RS27245	COG0628	permease
M1D19_RS27260	COG3279	Response regulator of the LytR AlgR family
M1D19_RS27265	COG3275	phosphorelay sensor kinase activity
M1D19_RS27270	COG2814	Major facilitator Superfamily
M1D19_RS27275	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1D19_RS27280	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M1D19_RS27285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1D19_RS27305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1D19_RS27310	COG1272	protein, Hemolysin III
M1D19_RS27330	COG0516	GMP reductase activity
M1D19_RS27335	COG1164	Oligoendopeptidase f
M1D19_RS27355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1D19_RS27360	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M1D19_RS27365	COG4853	Protein conserved in bacteria
M1D19_RS27370	COG4863	YycH protein
M1D19_RS27375	COG5002	protein histidine kinase activity
M1D19_RS27380	COG0745	RESPONSE REGULATOR receiver
M1D19_RS27410	COG0305	Participates in initiation and elongation during chromosome replication
M1D19_RS27420	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M1D19_RS27425	COG4241	membrane
M1D19_RS27435	COG0629	single-stranded DNA binding
M1D19_RS27445	COG0012	GTP binding
M1D19_RS27450	COG4481	Protein conserved in bacteria
M1D19_RS27455	COG0668	transmembrane transport
M1D19_RS27465	COG1475	DNA binding
M1D19_RS27470	COG1192	Involved in chromosome partitioning
M1D19_RS27495	COG1847	R3H domain protein
M1D19_RS27500	COG0706	membrane insertase activity
M1D19_RS27510	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M1D19_RS27615	COG4962	Type ii secretion system protein e
M1D19_RS27820	COG3344	reverse transcriptase
M1D19_RS27900	COG3344	reverse transcriptase
M1D19_RS28005	COG0457	Tetratricopeptide repeat
M1D19_RS28030	COG4974	Belongs to the 'phage' integrase family
M1D19_RS28040	COG3443	Belongs to the bacterial solute-binding protein 9 family
M1D19_RS28105	COG4974	Belongs to the 'phage' integrase family
M1D19_RS28115	COG2002	toxin-antitoxin pair type II binding
M1D19_RS28290	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M1D19_RS28295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1D19_RS28315	COG0671	phosphoesterase, PA-phosphatase related
M1D19_RS28320	COG4196	transglutaminase domain protein
M1D19_RS28345	COG2311	Membrane