locus-tag	class	description
L6178_RS00010	COG0592	DNA-directed DNA polymerase activity
L6178_RS00015	COG2501	S4 domain
L6178_RS00025	COG0187	DNA topoisomerase II activity
L6178_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L6178_RS00065	COG0516	GMP reductase activity
L6178_RS00065	COG0517	IMP dehydrogenase activity
L6178_RS00070	COG1686	Belongs to the peptidase S11 family
L6178_RS00100	COG1428	Deoxynucleoside kinase
L6178_RS00105	COG1428	Deoxynucleoside kinase
L6178_RS00110	COG1335	isochorismatase
L6178_RS00115	COG0590	tRNA wobble adenosine to inosine editing
L6178_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L6178_RS00180	COG1982	Orn Lys Arg decarboxylase major
L6178_RS00190	COG0470	DNA polymerase III
L6178_RS00195	COG1774	PSP1 C-terminal conserved region
L6178_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L6178_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L6178_RS00220	COG2002	toxin-antitoxin pair type II binding
L6178_RS00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6178_RS00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6178_RS00230	COG0084	hydrolase, TatD family'
L6178_RS00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L6178_RS00250	COG4466	Protein conserved in bacteria
L6178_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L6178_RS00270	COG0251	oxidation-reduction process
L6178_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L6178_RS00305	COG2002	toxin-antitoxin pair type II binding
L6178_RS00310	COG2244	polysaccharide biosynthetic process
L6178_RS00315	COG3956	TIGRFAM MazG family protein
L6178_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L6178_RS00340	COG1098	S1 RNA binding domain
L6178_RS00355	COG2208	phosphoserine phosphatase activity
L6178_RS00360	COG0037	tRNA processing
L6178_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L6178_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L6178_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6178_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L6178_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
L6178_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6178_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L6178_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L6178_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L6178_RS00420	COG1396	sequence-specific DNA binding
L6178_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6178_RS00455	COG3880	PFAM UvrB UvrC protein
L6178_RS00465	COG0542	response to heat
L6178_RS00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L6178_RS00480	COG4956	integral membrane protein (PIN domain superfamily)
L6178_RS00500	COG1045	serine acetyltransferase
L6178_RS00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6178_RS00520	COG3688	RNA-binding protein containing a PIN domain
L6178_RS00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L6178_RS00540	COG0250	Participates in transcription elongation, termination and antitermination
L6178_RS00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L6178_RS00565	COG2813	Specifically methylates the guanine in position
L6178_RS00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L6178_RS00580	COG1358	cellular component organization or biogenesis
L6178_RS00650	COG0255	Belongs to the universal ribosomal protein uL29 family
L6178_RS00710	COG0201	protein transport
L6178_RS00720	COG0024	Methionine aminopeptidase
L6178_RS00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L6178_RS00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L6178_RS00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6178_RS00795	COG0489	protein tyrosine kinase activity
L6178_RS00805	COG2194	sulfuric ester hydrolase activity
L6178_RS00810	COG0726	polysaccharide deacetylase
L6178_RS00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
L6178_RS00895	COG4856	YbbR-like protein
L6178_RS00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L6178_RS00915	COG0596	Alpha beta hydrolase
L6178_RS00935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L6178_RS00940	COG0823	Involved in the tonB-independent uptake of proteins
L6178_RS00940	COG4946	Tricorn protease homolog
L6178_RS00940	COG1506	peptidase
L6178_RS00975	COG2011	ABC-type metal ion transport system permease component
L6178_RS00980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6178_RS00985	COG1464	Belongs to the NlpA lipoprotein family
L6178_RS00990	COG0604	alcohol dehydrogenase
L6178_RS01000	COG0277	FAD linked oxidase domain protein
L6178_RS01005	COG2271	Major facilitator Superfamily
L6178_RS01015	COG2814	Major facilitator Superfamily
L6178_RS01030	COG0601	transmembrane transport
L6178_RS01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6178_RS01040	COG0444	Belongs to the ABC transporter superfamily
L6178_RS01045	COG4608	Belongs to the ABC transporter superfamily
L6178_RS01050	COG4166	transmembrane transport
L6178_RS01060	COG2207	Transcriptional regulator
L6178_RS01075	COG4166	transmembrane transport
L6178_RS01080	COG4166	transmembrane transport
L6178_RS01085	COG0656	L-ascorbic acid biosynthetic process
L6178_RS01105	COG4149	molybdate abc transporter
L6178_RS01115	COG1910	domain protein
L6178_RS01125	COG0583	DNA-binding transcription factor activity
L6178_RS01130	COG0697	spore germination
L6178_RS01145	COG0204	Acyl-transferase
L6178_RS01155	COG1609	Transcriptional regulator
L6178_RS01165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_RS01175	COG0084	hydrolase, TatD family'
L6178_RS01180	COG5298	Protein conserved in bacteria
L6178_RS01205	COG0488	(ABC) transporter
L6178_RS01220	COG0747	negative chemotaxis
L6178_RS01225	COG0601	transmembrane transport
L6178_RS01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6178_RS01235	COG0444	Belongs to the ABC transporter superfamily
L6178_RS01260	COG3185	4-Hydroxyphenylpyruvate dioxygenase
L6178_RS01265	COG0179	Fumarylacetoacetate (FAA) hydrolase
L6178_RS01275	COG2814	Major facilitator Superfamily
L6178_RS01285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L6178_RS01295	COG4294	response to UV
L6178_RS01300	COG0457	Tetratricopeptide repeat
L6178_RS01300	COG0705	Rhomboid family
L6178_RS01310	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L6178_RS01315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6178_RS01320	COG0864	Transcriptional regulator
L6178_RS01325	COG2337	Toxic component of a toxin-antitoxin (TA) module
L6178_RS01330	COG2183	response to ionizing radiation
L6178_RS01425	COG0802	atpase or kinase
L6178_RS01430	COG1214	PFAM Peptidase M22, glycoprotease
L6178_RS01435	COG0456	acetyltransferase
L6178_RS01460	COG1266	CAAX protease self-immunity
L6178_RS01480	COG2252	PERMEase
L6178_RS01490	COG5002	protein histidine kinase activity
L6178_RS01520	COG2226	methyltransferase
L6178_RS01565	COG1968	undecaprenyl-diphosphatase activity
L6178_RS01580	COG2205	protein histidine kinase activity
L6178_RS01585	COG0745	RESPONSE REGULATOR receiver
L6178_RS01610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L6178_RS01615	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L6178_RS01620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L6178_RS01630	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L6178_RS01645	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L6178_RS01655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L6178_RS01665	COG0151	Belongs to the GarS family
L6178_RS01690	COG0210	DNA helicase
L6178_RS01700	COG4851	CamS sex pheromone cAM373 precursor
L6178_RS01720	COG1335	isochorismatase
L6178_RS01725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6178_RS01730	COG2011	ABC-type metal ion transport system permease component
L6178_RS01735	COG1464	Belongs to the NlpA lipoprotein family
L6178_RS01760	COG1846	Transcriptional regulator
L6178_RS01785	COG1597	lipid kinase activity
L6178_RS01790	COG0546	phosphoglycolate phosphatase activity
L6178_RS01795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L6178_RS01805	COG1012	belongs to the aldehyde dehydrogenase family
L6178_RS01810	COG2076	Multidrug Resistance protein
L6178_RS01815	COG2309	aminopeptidase activity
L6178_RS01830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6178_RS01835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6178_RS01840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6178_RS01850	COG4807	Protein conserved in bacteria
L6178_RS01875	COG1757	Na H antiporter
L6178_RS01880	COG1473	amidohydrolase
L6178_RS01895	COG0450	alkyl hydroperoxide reductase
L6178_RS01915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_RS01920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_RS01925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6178_RS01940	COG0166	Belongs to the GPI family
L6178_RS01975	COG5002	protein histidine kinase activity
L6178_RS01995	COG3541	Predicted nucleotidyltransferase
L6178_RS02000	COG2814	Major facilitator Superfamily
L6178_RS02005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6178_RS02005	COG0723	plastoquinol--plastocyanin reductase activity
L6178_RS02015	COG0765	amino acid transport
L6178_RS02020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6178_RS02030	COG0840	transmembrane signaling receptor activity
L6178_RS02035	COG0840	transmembrane signaling receptor activity
L6178_RS02040	COG0366	Alpha amylase catalytic
L6178_RS02045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6178_RS02045	COG2190	(PTS) system
L6178_RS02045	COG1263	PTS System
L6178_RS02075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L6178_RS02090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6178_RS02100	COG1116	anion transmembrane transporter activity
L6178_RS02105	COG0488	(ABC) transporter
L6178_RS02150	COG2270	Major facilitator Superfamily
L6178_RS02165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6178_RS02180	COG2310	stress, protein
L6178_RS02185	COG2310	stress, protein
L6178_RS02190	COG2310	stress, protein
L6178_RS02195	COG0861	Integral membrane protein TerC family
L6178_RS02205	COG3853	Toxic anion resistance protein (TelA)
L6178_RS02220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L6178_RS02230	COG1295	ribonuclease BN
L6178_RS02235	COG2217	Heavy metal translocating P-type atpase
L6178_RS02240	COG0697	spore germination
L6178_RS02260	COG0586	Pfam SNARE associated Golgi protein
L6178_RS02275	COG3871	stress protein (general stress protein 26)
L6178_RS02280	COG0387	Pfam Sodium calcium exchanger
L6178_RS02290	COG0535	radical SAM domain protein
L6178_RS02315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6178_RS02320	COG0582	viral genome integration into host DNA
L6178_RS02330	COG1396	sequence-specific DNA binding
L6178_RS02345	COG1396	sequence-specific DNA binding
L6178_RS02380	COG1484	DNA-dependent DNA replication
L6178_RS02610	COG0101	tRNA pseudouridine synthase activity
L6178_RS02620	COG3829	transcription factor binding
L6178_RS02630	COG0833	amino acid
L6178_RS02635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6178_RS02665	COG1263	PTS System
L6178_RS02665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6178_RS02670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6178_RS02685	COG0463	Glycosyl transferase, family 2
L6178_RS02695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L6178_RS02695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6178_RS02710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L6178_RS02730	COG1228	amidohydrolase
L6178_RS02735	COG1090	epimerase
L6178_RS02765	COG1988	membrane-bound metal-dependent
L6178_RS02770	COG1194	a g-specific adenine glycosylase
L6178_RS02795	COG1132	(ABC) transporter
L6178_RS02800	COG4129	membrane
L6178_RS02805	COG0067	glutamate synthase
L6178_RS02805	COG0069	glutamate synthase activity
L6178_RS02805	COG0070	glutamate synthase
L6178_RS02815	COG4555	ABC transporter
L6178_RS02835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L6178_RS02840	COG0735	belongs to the Fur family
L6178_RS02955	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
L6178_RS02960	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L6178_RS02970	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L6178_RS02980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L6178_RS02990	COG2766	serine protein kinase
L6178_RS03010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6178_RS03020	COG1585	Membrane protein implicated in regulation of membrane protease activity
L6178_RS03025	COG2268	Band 7 protein
L6178_RS03035	COG3290	protein histidine kinase activity
L6178_RS03045	COG2851	Citrate transporter
L6178_RS03065	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
L6178_RS03070	COG3842	ATPase activity
L6178_RS03075	COG1175	transmembrane transport
L6178_RS03080	COG0395	ABC-type sugar transport system, permease component
L6178_RS03090	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L6178_RS03095	COG0745	RESPONSE REGULATOR receiver
L6178_RS03100	COG5002	protein histidine kinase activity
L6178_RS03110	COG4990	cell redox homeostasis
L6178_RS03120	COG3290	protein histidine kinase activity
L6178_RS03125	COG4565	transcriptional regulatory protein
L6178_RS03130	COG3493	citrate carrier protein
L6178_RS03135	COG0281	malic enzyme
L6178_RS03150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6178_RS03160	COG5002	protein histidine kinase activity
L6178_RS03165	COG0745	RESPONSE REGULATOR receiver
L6178_RS03170	COG0456	acetyltransferase
L6178_RS03170	COG0454	-acetyltransferase
L6178_RS03175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L6178_RS03180	COG3383	formate dehydrogenase (NAD+) activity
L6178_RS03200	COG0531	amino acid
L6178_RS03205	COG0640	Transcriptional regulator
L6178_RS03210	COG2217	Heavy metal translocating P-type atpase
L6178_RS03215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L6178_RS03230	COG3227	Zinc metalloprotease (Elastase)
L6178_RS03250	COG2720	vancomycin resistance protein
L6178_RS03255	COG1316	TRANSCRIPTIONal
L6178_RS03260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6178_RS03265	COG0346	lactoylglutathione lyase activity
L6178_RS03275	COG1027	Aspartate ammonia-lyase
L6178_RS03280	COG1620	l-lactate permease
L6178_RS03295	COG3104	oligopeptide transport
L6178_RS03300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6178_RS03305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_RS03310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_RS03320	COG2226	methyltransferase
L6178_RS03325	COG0156	8-amino-7-oxononanoate synthase activity
L6178_RS03340	COG4548	von Willebrand factor, type A
L6178_RS03345	COG0714	Associated with various cellular activities
L6178_RS03350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6178_RS03370	COG0531	amino acid
L6178_RS03375	COG2188	Transcriptional regulator
L6178_RS03380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6178_RS03380	COG1263	PTS System
L6178_RS03385	COG0366	Alpha amylase catalytic
L6178_RS03400	COG0697	spore germination
L6178_RS03410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6178_RS03415	COG1115	amino acid carrier protein
L6178_RS03420	COG1126	abc transporter atp-binding protein
L6178_RS03425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6178_RS03430	COG0765	amino acid transport
L6178_RS03435	COG0765	amino acid transport
L6178_RS03440	COG0833	amino acid
L6178_RS03465	COG2378	regulation of single-species biofilm formation
L6178_RS03470	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L6178_RS03475	COG5002	protein histidine kinase activity
L6178_RS03490	COG0659	secondary active sulfate transmembrane transporter activity
L6178_RS03505	COG0747	negative chemotaxis
L6178_RS03515	COG0601	transmembrane transport
L6178_RS03520	COG4608	Belongs to the ABC transporter superfamily
L6178_RS03530	COG2271	Major facilitator Superfamily
L6178_RS03535	COG1846	Transcriptional regulator
L6178_RS03545	COG1609	Transcriptional regulator
L6178_RS03550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6178_RS03565	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6178_RS03570	COG1879	ABC-type sugar transport system periplasmic component
L6178_RS03595	COG1063	alcohol dehydrogenase
L6178_RS03610	COG3568	Endonuclease Exonuclease Phosphatase
L6178_RS03635	COG1968	undecaprenyl-diphosphatase activity
L6178_RS03640	COG0840	transmembrane signaling receptor activity
L6178_RS03645	COG1388	LysM domain
L6178_RS03645	COG3584	3D domain protein
L6178_RS03650	COG1476	TRANSCRIPTIONal
L6178_RS03665	COG3104	oligopeptide transport
L6178_RS03670	COG1114	Component of the transport system for branched-chain amino acids
L6178_RS03685	COG1113	amino acid transport
L6178_RS03690	COG2252	PERMEase
L6178_RS03715	COG0569	domain protein
L6178_RS03715	COG0475	glutathione-regulated potassium exporter activity
L6178_RS03730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L6178_RS03735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L6178_RS03740	COG4990	cell redox homeostasis
L6178_RS03755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6178_RS03760	COG0697	spore germination
L6178_RS03765	COG0531	amino acid
L6178_RS03775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6178_RS03780	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6178_RS03785	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6178_RS03785	COG1918	ferrous iron import across plasma membrane
L6178_RS03790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L6178_RS03795	COG0573	inorganic phosphate transmembrane transporter activity
L6178_RS03800	COG0581	inorganic phosphate transmembrane transporter activity
L6178_RS03810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6178_RS03925	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
L6178_RS03945	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L6178_RS03950	COG1116	anion transmembrane transporter activity
L6178_RS03955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6178_RS03960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6178_RS03965	COG0352	thiamine-phosphate diphosphorylase activity
L6178_RS03970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6178_RS03975	COG2104	thiamine diphosphate biosynthetic process
L6178_RS03985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6178_RS03990	COG0351	phosphomethylpyrimidine kinase
L6178_RS04030	COG2205	protein histidine kinase activity
L6178_RS04035	COG2814	Major facilitator Superfamily
L6178_RS04040	COG1846	Transcriptional regulator
L6178_RS04055	COG2252	PERMEase
L6178_RS04060	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_RS04075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6178_RS04080	COG1621	beta-fructofuranosidase activity
L6178_RS04085	COG1263	PTS System
L6178_RS04085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6178_RS04090	COG1609	Transcriptional regulator
L6178_RS04100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6178_RS04105	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
L6178_RS04140	COG0778	Nitroreductase
L6178_RS04145	COG2719	SpoVR family
L6178_RS04170	COG0446	pyridine nucleotide-disulphide oxidoreductase
L6178_RS04175	COG1937	Protein conserved in bacteria
L6178_RS04180	COG0425	Belongs to the sulfur carrier protein TusA family
L6178_RS04180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6178_RS04185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6178_RS04185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_RS04190	COG0425	Belongs to the sulfur carrier protein TusA family
L6178_RS04205	COG2210	Belongs to the sulfur carrier protein TusA family
L6178_RS04210	COG0730	response to heat
L6178_RS04220	COG1316	TRANSCRIPTIONal
L6178_RS04225	COG0604	alcohol dehydrogenase
L6178_RS04230	COG1283	sodium-dependent phosphate transmembrane transporter activity
L6178_RS04245	COG3711	transcriptional antiterminator
L6178_RS04245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6178_RS04250	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6178_RS04255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6178_RS04275	COG1388	LysM domain
L6178_RS04275	COG3584	3D domain protein
L6178_RS04280	COG0577	efflux transmembrane transporter activity
L6178_RS04285	COG1136	(ABC) transporter
L6178_RS04295	COG5522	Integral membrane protein (intg_mem_TP0381)
L6178_RS04310	COG1114	Component of the transport system for branched-chain amino acids
L6178_RS04315	COG3546	catalase activity
L6178_RS04350	COG0586	Pfam SNARE associated Golgi protein
L6178_RS04385	COG0531	amino acid
L6178_RS04390	COG0475	glutathione-regulated potassium exporter activity
L6178_RS04400	COG1737	Transcriptional regulator
L6178_RS04410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6178_RS04410	COG1263	PTS System
L6178_RS04420	COG2259	Doxx family
L6178_RS04435	COG0697	spore germination
L6178_RS04440	COG1522	sequence-specific DNA binding
L6178_RS04455	COG2076	Multidrug Resistance protein
L6178_RS04460	COG1309	transcriptional regulator
L6178_RS04465	COG2814	Major facilitator Superfamily
L6178_RS04470	COG1733	regulation of RNA biosynthetic process
L6178_RS04480	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6178_RS04485	COG4533	DNA binding
L6178_RS04490	COG2211	Major facilitator Superfamily
L6178_RS04500	COG0693	protein deglycase activity
L6178_RS04505	COG0753	catalase activity
L6178_RS04505	COG0693	protein deglycase activity
L6178_RS04515	COG0531	amino acid
L6178_RS04520	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L6178_RS04530	COG1012	belongs to the aldehyde dehydrogenase family
L6178_RS04535	COG1132	(ABC) transporter
L6178_RS04545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6178_RS04550	COG0765	amino acid transport
L6178_RS04555	COG1126	abc transporter atp-binding protein
L6178_RS04570	COG0189	ligase activity
L6178_RS04600	COG0028	Belongs to the TPP enzyme family
L6178_RS04605	COG3527	Alpha-acetolactate decarboxylase
L6178_RS04620	COG0561	phosphatase activity
L6178_RS04635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6178_RS04650	COG0659	secondary active sulfate transmembrane transporter activity
L6178_RS04670	COG0653	protein targeting
L6178_RS04675	COG2244	polysaccharide biosynthetic process
L6178_RS04685	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6178_RS04690	COG4196	transglutaminase domain protein
L6178_RS04705	COG1696	Membrane protein involved in D-alanine export
L6178_RS04720	COG1024	Enoyl-CoA hydratase
L6178_RS04740	COG1363	Peptidase, m42
L6178_RS04760	COG3938	Belongs to the proline racemase family
L6178_RS04800	COG0601	transmembrane transport
L6178_RS04805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6178_RS04815	COG4608	Belongs to the ABC transporter superfamily
L6178_RS04850	COG0477	Major facilitator Superfamily
L6178_RS04855	COG3290	protein histidine kinase activity
L6178_RS04860	COG4565	transcriptional regulatory protein
L6178_RS04865	COG3181	Tripartite tricarboxylate transporter family receptor
L6178_RS04895	COG4978	Transcriptional regulator
L6178_RS04895	COG0789	Transcriptional regulator
L6178_RS04910	COG0305	Participates in initiation and elongation during chromosome replication
L6178_RS04950	COG0477	Major facilitator Superfamily
L6178_RS04995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6178_RS04995	COG3320	Male sterility
L6178_RS05000	COG1309	transcriptional regulator
L6178_RS05020	COG1183	phosphatidylcholine synthase activity
L6178_RS05040	COG2376	Dihydroxyacetone kinase
L6178_RS05050	COG2376	Dihydroxyacetone kinase
L6178_RS05055	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L6178_RS05060	COG1959	2 iron, 2 sulfur cluster binding
L6178_RS05090	COG3437	response regulator, receiver
L6178_RS05090	COG2770	Histidine kinase
L6178_RS05145	COG3237	CsbD-like
L6178_RS05170	COG1191	sigma factor activity
L6178_RS05180	COG2208	phosphoserine phosphatase activity
L6178_RS05185	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L6178_RS05190	COG0784	Response regulator, receiver
L6178_RS05190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6178_RS05190	COG2198	Histidine kinase
L6178_RS05190	COG2205	protein histidine kinase activity
L6178_RS05245	COG0420	3'-5' exonuclease activity
L6178_RS05270	COG1309	transcriptional regulator
L6178_RS05275	COG2814	Major facilitator Superfamily
L6178_RS05280	COG0346	lactoylglutathione lyase activity
L6178_RS05285	COG0346	lactoylglutathione lyase activity
L6178_RS05290	COG0457	Tetratricopeptide repeat
L6178_RS05295	COG2267	carboxylic ester hydrolase activity
L6178_RS05315	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
L6178_RS05320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L6178_RS05330	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L6178_RS05370	COG0477	Major facilitator Superfamily
L6178_RS05375	COG0477	Major facilitator Superfamily
L6178_RS05385	COG3973	AAA domain
L6178_RS05390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6178_RS05410	COG4980	gas vesicle protein
L6178_RS05415	COG0537	adenosine 5'-monophosphoramidase activity
L6178_RS05420	COG1131	(ABC) transporter
L6178_RS05425	COG4473	ABC transporter
L6178_RS05440	COG1309	transcriptional regulator
L6178_RS05450	COG3402	PFAM membrane-flanked domain
L6178_RS05495	COG3402	PFAM membrane-flanked domain
L6178_RS05500	COG3428	Bacterial PH domain
L6178_RS05505	COG2329	Antibiotic biosynthesis monooxygenase
L6178_RS05510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6178_RS05515	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L6178_RS05520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L6178_RS05525	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L6178_RS05560	COG1309	transcriptional regulator
L6178_RS05565	COG1511	domain protein
L6178_RS05590	COG1609	Transcriptional regulator
L6178_RS05600	COG1234	tRNA 3'-trailer cleavage
L6178_RS05605	COG0095	Lipoate-protein ligase
L6178_RS05615	COG0318	PFAM AMP-dependent synthetase and ligase
L6178_RS05645	COG3209	COG3209 Rhs family protein
L6178_RS05685	COG1078	dGTPase activity
L6178_RS05695	COG1595	DNA-templated transcription, initiation
L6178_RS05700	COG3708	Transcriptional regulator
L6178_RS05700	COG2207	Transcriptional regulator
L6178_RS05715	COG2205	protein histidine kinase activity
L6178_RS05720	COG0745	RESPONSE REGULATOR receiver
L6178_RS05745	COG0501	Belongs to the peptidase M48B family
L6178_RS05750	COG0840	transmembrane signaling receptor activity
L6178_RS05755	COG0697	spore germination
L6178_RS05775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L6178_RS05780	COG2224	Isocitrate lyase
L6178_RS05805	COG4903	ComK protein
L6178_RS05810	COG0398	Pfam SNARE associated Golgi protein
L6178_RS05820	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
L6178_RS05825	COG1074	ATP-dependent DNA helicase activity
L6178_RS05870	COG0179	Fumarylacetoacetate (FAA) hydrolase
L6178_RS05895	COG0367	asparagine synthase
L6178_RS05900	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L6178_RS05905	COG0753	catalase activity
L6178_RS05910	COG0004	ammonium transporteR
L6178_RS05930	COG2996	Protein conserved in bacteria
L6178_RS05940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6178_RS05950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_RS05965	COG0561	phosphatase activity
L6178_RS05975	COG0542	response to heat
L6178_RS05985	COG2267	carboxylic ester hydrolase activity
L6178_RS06000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6178_RS06005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L6178_RS06010	COG5504	Zn-dependent protease
L6178_RS06020	COG0180	Tryptophanyl-tRNA synthetase
L6178_RS06030	COG4166	transmembrane transport
L6178_RS06035	COG0601	transmembrane transport
L6178_RS06040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6178_RS06045	COG0444	Belongs to the ABC transporter superfamily
L6178_RS06050	COG4608	Belongs to the ABC transporter superfamily
L6178_RS06055	COG0534	Mate efflux family protein
L6178_RS06060	COG4166	transmembrane transport
L6178_RS06075	COG0861	Integral membrane protein TerC family
L6178_RS06080	COG4862	establishment of competence for transformation
L6178_RS06085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6178_RS06095	COG1164	Oligoendopeptidase f
L6178_RS06105	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L6178_RS06110	COG2346	COG2346, Truncated hemoglobins
L6178_RS06115	COG4116	CYTH
L6178_RS06125	COG2357	RelA SpoT domain protein
L6178_RS06135	COG0564	pseudouridine synthase activity
L6178_RS06155	COG1216	Glycosyl transferase, family 2
L6178_RS06155	COG0463	Glycosyl transferase, family 2
L6178_RS06175	COG0463	Glycosyl transferase, family 2
L6178_RS06175	COG0457	Tetratricopeptide repeat
L6178_RS06195	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
L6178_RS06210	COG1091	dTDP-4-dehydrorhamnose reductase activity
L6178_RS06255	COG2153	protein acetylation
L6178_RS06265	COG2382	esterase
L6178_RS06280	COG5492	domain, Protein
L6178_RS06285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6178_RS06295	COG0512	Glutamine amidotransferase of anthranilate synthase
L6178_RS06295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L6178_RS06330	COG1620	l-lactate permease
L6178_RS06335	COG5634	Uncharacterized conserved protein (DUF2278)
L6178_RS06390	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6178_RS06400	COG1476	TRANSCRIPTIONal
L6178_RS06460	COG2226	methyltransferase
L6178_RS06470	COG1686	Belongs to the peptidase S11 family
L6178_RS06475	COG0681	Belongs to the peptidase S26 family
L6178_RS06510	COG1012	belongs to the aldehyde dehydrogenase family
L6178_RS06515	COG3842	ATPase activity
L6178_RS06520	COG1176	ABC-type spermidine putrescine transport system, permease component I
L6178_RS06525	COG1177	transmembrane transport
L6178_RS06530	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L6178_RS06540	COG2409	Drug exporters of the RND superfamily
L6178_RS06550	COG0564	pseudouridine synthase activity
L6178_RS06560	COG2340	Cysteine-rich secretory protein family
L6178_RS06565	COG0247	lactate metabolic process
L6178_RS06570	COG0277	FAD linked oxidase domain protein
L6178_RS06575	COG3835	regulator
L6178_RS06585	COG0745	RESPONSE REGULATOR receiver
L6178_RS06590	COG5002	protein histidine kinase activity
L6178_RS06595	COG2186	Transcriptional regulator
L6178_RS06615	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L6178_RS06625	COG2116	formate transmembrane transporter activity
L6178_RS06630	COG0861	Integral membrane protein TerC family
L6178_RS06635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6178_RS06645	COG2030	dehydratase
L6178_RS06665	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_RS06670	COG3243	poly(R)-hydroxyalkanoic acid synthase
L6178_RS06675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6178_RS06680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6178_RS06695	COG1840	ABC-type Fe3 transport system, periplasmic component
L6178_RS06725	COG1349	DNA-binding transcription factor activity
L6178_RS06745	COG2861	carbohydrate metabolic process
L6178_RS06755	COG3852	Histidine kinase
L6178_RS06760	COG1846	Transcriptional regulator
L6178_RS06770	COG2318	DinB family
L6178_RS06780	COG5002	protein histidine kinase activity
L6178_RS06790	COG0720	synthase
L6178_RS06805	COG4873	Protein conserved in bacteria
L6178_RS06835	COG1780	Probably involved in ribonucleotide reductase function
L6178_RS06855	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L6178_RS06860	COG1725	Transcriptional regulator
L6178_RS06865	COG1131	(ABC) transporter
L6178_RS06875	COG1131	(ABC) transporter
L6178_RS06880	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6178_RS06895	COG1522	sequence-specific DNA binding
L6178_RS06905	COG1335	isochorismatase
L6178_RS06915	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6178_RS06920	COG2070	2-Nitropropane dioxygenase
L6178_RS06925	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L6178_RS06935	COG1696	Membrane protein involved in D-alanine export
L6178_RS06960	COG0716	FMN binding
L6178_RS06975	COG3173	Aminoglycoside phosphotransferase
L6178_RS06995	COG0534	Mate efflux family protein
L6178_RS07000	COG1968	undecaprenyl-diphosphatase activity
L6178_RS07015	COG1846	Transcriptional regulator
L6178_RS07025	COG1301	dicarboxylic acid transport
L6178_RS07030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6178_RS07035	COG4709	membrane
L6178_RS07040	COG3874	Sporulation protein YtfJ
L6178_RS07065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6178_RS07070	COG0028	Belongs to the TPP enzyme family
L6178_RS07075	COG0440	acetolactate synthase activity
L6178_RS07080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L6178_RS07090	COG0473	3-isopropylmalate dehydrogenase activity
L6178_RS07115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L6178_RS07150	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L6178_RS07165	COG1183	phosphatidylcholine synthase activity
L6178_RS07170	COG1368	sulfuric ester hydrolase activity
L6178_RS07180	COG0019	diaminopimelate decarboxylase activity
L6178_RS07200	COG0529	Catalyzes the synthesis of activated sulfate
L6178_RS07205	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6178_RS07225	COG1648	precorrin-2 dehydrogenase activity
L6178_RS07230	COG0733	neurotransmitter:sodium symporter activity
L6178_RS07250	COG1757	Na H antiporter
L6178_RS07265	COG4758	membrane
L6178_RS07270	COG4585	Histidine kinase
L6178_RS07275	COG2197	response regulator
L6178_RS07285	COG1114	Component of the transport system for branched-chain amino acids
L6178_RS07295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L6178_RS07320	COG1017	nitric oxide dioxygenase activity
L6178_RS07320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L6178_RS07335	COG0730	response to heat
L6178_RS07340	COG0306	phosphate transporter
L6178_RS07345	COG1392	Phosphate transport regulator
L6178_RS07350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6178_RS07365	COG3852	Histidine kinase
L6178_RS07370	COG1801	Protein of unknown function DUF72
L6178_RS07380	COG0582	viral genome integration into host DNA
L6178_RS07385	COG5002	protein histidine kinase activity
L6178_RS07405	COG0392	lysyltransferase activity
L6178_RS07405	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
L6178_RS07420	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6178_RS07425	COG1686	Belongs to the peptidase S11 family
L6178_RS07430	COG2715	membrane protein required for spore maturation
L6178_RS07435	COG0700	Nucleoside recognition
L6178_RS07440	COG1187	pseudouridine synthase activity
L6178_RS07450	COG1333	cytochrome c biogenesis protein
L6178_RS07455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6178_RS07460	COG0745	RESPONSE REGULATOR receiver
L6178_RS07465	COG5002	protein histidine kinase activity
L6178_RS07470	COG2096	Adenosyltransferase
L6178_RS07485	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
L6178_RS07490	COG1141	Ferredoxin
L6178_RS07495	COG4955	Helix-turn-helix domain
L6178_RS07500	COG0514	ATP-dependent DNA helicase (RecQ)
L6178_RS07505	COG1266	CAAX protease self-immunity
L6178_RS07525	COG4862	establishment of competence for transformation
L6178_RS07530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L6178_RS07550	COG0492	ferredoxin-NADP+ reductase activity
L6178_RS07625	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6178_RS07640	COG0142	geranyltranstransferase activity
L6178_RS07650	COG0142	geranyltranstransferase activity
L6178_RS07670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L6178_RS07675	COG0457	Tetratricopeptide repeat
L6178_RS07695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L6178_RS07705	COG4347	Protein of unknown function (DUF1405)
L6178_RS07720	COG2738	Putative neutral zinc metallopeptidase
L6178_RS07730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_RS07735	COG1694	Mazg nucleotide pyrophosphohydrolase
L6178_RS07750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6178_RS07755	COG0438	transferase activity, transferring glycosyl groups
L6178_RS07790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L6178_RS07790	COG1199	ATP-dependent helicase activity
L6178_RS07810	COG3935	DnaD domain protein
L6178_RS07815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L6178_RS07825	COG4499	WXG100 protein secretion system (Wss), protein YukC
L6178_RS07825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6178_RS07885	COG0116	Belongs to the methyltransferase superfamily
L6178_RS07895	COG1199	ATP-dependent helicase activity
L6178_RS07900	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
L6178_RS07910	COG3173	Aminoglycoside phosphotransferase
L6178_RS07915	COG0024	Methionine aminopeptidase
L6178_RS07925	COG2233	PERMEase
L6178_RS07930	COG2311	Membrane
L6178_RS07935	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6178_RS07945	COG0456	acetyltransferase
L6178_RS07995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6178_RS08020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L6178_RS08035	COG1215	transferase activity, transferring glycosyl groups
L6178_RS08040	COG0438	transferase activity, transferring glycosyl groups
L6178_RS08055	COG0454	-acetyltransferase
L6178_RS08075	COG0328	RNA-DNA hybrid ribonuclease activity
L6178_RS08115	COG1280	lysine exporter protein (LysE YggA)
L6178_RS08130	COG3162	membrane
L6178_RS08135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6178_RS08140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6178_RS08150	COG0475	glutathione-regulated potassium exporter activity
L6178_RS08155	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L6178_RS08160	COG4978	Transcriptional regulator
L6178_RS08160	COG0789	Transcriptional regulator
L6178_RS08170	COG2323	membrane
L6178_RS08175	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L6178_RS08230	COG1923	regulation of RNA biosynthetic process
L6178_RS08240	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6178_RS08245	COG1360	Flagellar Motor Protein
L6178_RS08250	COG2201	protein-glutamate methylesterase activity
L6178_RS08260	COG1776	CheC inhibitor of MCP methylation
L6178_RS08260	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6178_RS08275	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L6178_RS08295	COG1256	bacterial-type flagellum assembly
L6178_RS08320	COG1815	bacterial-type flagellum-dependent cell motility
L6178_RS08325	COG1558	bacterial-type flagellum-dependent cell motility
L6178_RS08340	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6178_RS08350	COG1157	protein secretion by the type III secretion system
L6178_RS08395	COG0463	Glycosyl transferase, family 2
L6178_RS08420	COG0457	Tetratricopeptide repeat
L6178_RS08420	COG0463	Glycosyl transferase, family 2
L6178_RS08435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L6178_RS08440	COG0741	lytic transglycosylase activity
L6178_RS08455	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6178_RS08455	COG1776	CheC inhibitor of MCP methylation
L6178_RS08465	COG1338	Plays a role in the flagellum-specific transport system
L6178_RS08470	COG1987	bacterial-type flagellum assembly
L6178_RS08480	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6178_RS08485	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6178_RS08495	COG4786	Flagellar basal body rod
L6178_RS08500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6178_RS08525	COG1309	transcriptional regulator
L6178_RS08545	COG2329	Antibiotic biosynthesis monooxygenase
L6178_RS08570	COG0583	DNA-binding transcription factor activity
L6178_RS08580	COG0725	ABC transporter, periplasmic molybdate-binding protein
L6178_RS08590	COG1234	tRNA 3'-trailer cleavage
L6178_RS08615	COG1686	Belongs to the peptidase S11 family
L6178_RS08625	COG0406	alpha-ribazole phosphatase activity
L6178_RS08655	COG0367	asparagine synthase
L6178_RS08685	COG1802	Transcriptional regulator
L6178_RS08690	COG0697	spore germination
L6178_RS08695	COG0523	cobalamin synthesis protein
L6178_RS08700	COG0701	Predicted permease
L6178_RS08710	COG1216	Glycosyl transferase, family 2
L6178_RS08710	COG0438	transferase activity, transferring glycosyl groups
L6178_RS08715	COG1757	Na H antiporter
L6178_RS08720	COG0114	fumarate hydratase activity
L6178_RS08745	COG3340	Belongs to the peptidase S51 family
L6178_RS08765	COG0785	Cytochrome C biogenesis protein
L6178_RS08795	COG2733	membrane
L6178_RS08830	COG1131	(ABC) transporter
L6178_RS08845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6178_RS08850	COG0528	UMP kinase activity
L6178_RS08860	COG1027	Aspartate ammonia-lyase
L6178_RS08865	COG0281	malic enzyme
L6178_RS08870	COG4191	Histidine kinase
L6178_RS08875	COG0784	Response regulator, receiver
L6178_RS08880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6178_RS08940	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6178_RS08950	COG2814	Major facilitator Superfamily
L6178_RS08965	COG1966	Carbon starvation protein
L6178_RS08980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6178_RS08990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L6178_RS09000	COG2223	nitrite transmembrane transporter activity
L6178_RS09005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6178_RS09020	COG2244	polysaccharide biosynthetic process
L6178_RS09025	COG0733	neurotransmitter:sodium symporter activity
L6178_RS09035	COG5566	PFAM Mor transcription activator
L6178_RS09040	COG2323	membrane
L6178_RS09060	COG2084	Dehydrogenase
L6178_RS09075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6178_RS09085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6178_RS09090	COG0028	Belongs to the TPP enzyme family
L6178_RS09095	COG0440	acetolactate synthase activity
L6178_RS09100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L6178_RS09110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L6178_RS09135	COG2814	Major facilitator Superfamily
L6178_RS09140	COG3384	dioxygenase
L6178_RS09150	COG3279	Response regulator of the LytR AlgR family
L6178_RS09155	COG0427	acetyl-CoA hydrolase
L6178_RS09175	COG1073	alpha beta
L6178_RS09205	COG0535	radical SAM domain protein
L6178_RS09210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_RS09230	COG1914	H( )-stimulated, divalent metal cation uptake system
L6178_RS09245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L6178_RS09275	COG2390	Transcriptional regulator
L6178_RS09285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6178_RS09290	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L6178_RS09305	COG4224	UPF0291 protein
L6178_RS09325	COG0006	proline dipeptidase activity
L6178_RS09330	COG2132	Multicopper oxidase
L6178_RS09345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L6178_RS09360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L6178_RS09375	COG2372	response to copper ion
L6178_RS09375	COG1276	copper resistance
L6178_RS09380	COG4549	nuclear export factor GLE1
L6178_RS09390	COG0697	spore germination
L6178_RS09395	COG0583	DNA-binding transcription factor activity
L6178_RS09400	COG1959	2 iron, 2 sulfur cluster binding
L6178_RS09405	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L6178_RS09410	COG0778	Nitroreductase
L6178_RS09420	COG0628	permease
L6178_RS09430	COG1231	oxidoreductase activity
L6178_RS09435	COG0523	cobalamin synthesis protein
L6178_RS09450	COG0318	PFAM AMP-dependent synthetase and ligase
L6178_RS09455	COG2030	dehydratase
L6178_RS09460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6178_RS09470	COG0411	ABC transporter
L6178_RS09490	COG0583	DNA-binding transcription factor activity
L6178_RS09500	COG1942	4-Oxalocrotonate Tautomerase
L6178_RS09510	COG1846	Transcriptional regulator
L6178_RS09520	COG1271	oxidase subunit
L6178_RS09525	COG1294	oxidase, subunit
L6178_RS09530	COG4988	ABC transporter
L6178_RS09535	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L6178_RS09555	COG1686	Belongs to the peptidase S11 family
L6178_RS09570	COG1388	LysM domain
L6178_RS09570	COG0791	NLP P60 protein
L6178_RS09585	COG0745	RESPONSE REGULATOR receiver
L6178_RS09590	COG5002	protein histidine kinase activity
L6178_RS09600	COG0300	oxidoreductase activity
L6178_RS09635	COG0460	homoserine dehydrogenase
L6178_RS09660	COG1316	TRANSCRIPTIONal
L6178_RS09670	COG0745	RESPONSE REGULATOR receiver
L6178_RS09675	COG5002	protein histidine kinase activity
L6178_RS09690	COG1285	pathogenesis
L6178_RS09695	COG1247	-acetyltransferase
L6178_RS09715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6178_RS09725	COG1082	Xylose isomerase domain protein TIM barrel
L6178_RS09740	COG1279	arginine transmembrane transporter activity
L6178_RS09750	COG1752	Esterase of the alpha-beta hydrolase superfamily
L6178_RS09790	COG2002	toxin-antitoxin pair type II binding
L6178_RS09795	COG1404	Belongs to the peptidase S8 family
L6178_RS09800	COG0640	Transcriptional regulator
L6178_RS09805	COG0667	Aldo Keto reductase
L6178_RS09810	COG2814	Major facilitator Superfamily
L6178_RS09835	COG0840	transmembrane signaling receptor activity
L6178_RS09850	COG3949	Membrane
L6178_RS09855	COG0783	Belongs to the Dps family
L6178_RS09870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6178_RS09880	COG1231	oxidoreductase activity
L6178_RS09890	COG4989	oxidoreductase activity
L6178_RS09895	COG0523	cobalamin synthesis protein
L6178_RS09900	COG0456	acetyltransferase
L6178_RS09960	COG0803	Belongs to the bacterial solute-binding protein 9 family
L6178_RS09960	COG3443	Belongs to the bacterial solute-binding protein 9 family
L6178_RS09970	COG0702	epimerase
L6178_RS09980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L6178_RS09990	COG4166	transmembrane transport
L6178_RS10005	COG0406	alpha-ribazole phosphatase activity
L6178_RS10015	COG5337	Spore coat protein CotH
L6178_RS10020	COG1051	belongs to the nudix hydrolase family
L6178_RS10025	COG0586	Pfam SNARE associated Golgi protein
L6178_RS10030	COG2244	polysaccharide biosynthetic process
L6178_RS10040	COG0701	Predicted permease
L6178_RS10045	COG3689	TIGRFAM TIGR03943 family protein
L6178_RS10050	COG1607	acyl-coa hydrolase
L6178_RS10075	COG0702	epimerase
L6178_RS10080	COG2839	Protein conserved in bacteria
L6178_RS10085	COG1253	flavin adenine dinucleotide binding
L6178_RS10100	COG1114	Component of the transport system for branched-chain amino acids
L6178_RS10105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6178_RS10125	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6178_RS10135	COG1876	peptidase activity
L6178_RS10145	COG0154	amidase activity
L6178_RS10150	COG2211	Major facilitator Superfamily
L6178_RS10170	COG0561	phosphatase activity
L6178_RS10180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6178_RS10185	COG4106	trans-aconitate 2-methyltransferase activity
L6178_RS10200	COG1819	glycosyl
L6178_RS10205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_RS10210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6178_RS10245	COG0456	acetyltransferase
L6178_RS10300	COG3874	Sporulation protein YtfJ
L6178_RS10325	COG2226	methyltransferase
L6178_RS10350	COG0346	lactoylglutathione lyase activity
L6178_RS10360	COG0604	alcohol dehydrogenase
L6178_RS10365	COG1595	DNA-templated transcription, initiation
L6178_RS10390	COG0386	Belongs to the glutathione peroxidase family
L6178_RS10395	COG1305	Transglutaminase-like
L6178_RS10400	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
L6178_RS10405	COG0714	Associated with various cellular activities
L6178_RS10420	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
L6178_RS10425	COG1140	nitrate reductase beta subunit
L6178_RS10430	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
L6178_RS10435	COG2181	nitrate reductase activity
L6178_RS10455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6178_RS10460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L6178_RS10465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6178_RS10470	COG0303	'Molybdopterin
L6178_RS10475	COG0314	molybdopterin synthase activity
L6178_RS10485	COG2223	nitrite transmembrane transporter activity
L6178_RS10500	COG1648	precorrin-2 dehydrogenase activity
L6178_RS10510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L6178_RS10510	COG1587	Uroporphyrinogen-III synthase
L6178_RS10515	COG2146	nitrite reductase [NAD(P)H] activity
L6178_RS10520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6178_RS10525	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
L6178_RS10560	COG2359	stage V sporulation protein S
L6178_RS10585	COG1418	mRNA catabolic process
L6178_RS10590	COG0488	(ABC) transporter
L6178_RS10605	COG0629	single-stranded DNA binding
L6178_RS10620	COG1413	lyase activity
L6178_RS10635	COG2136	Putative SAM-dependent methyltransferase
L6178_RS10635	COG2521	methyltransferase
L6178_RS10640	COG0018	arginyl-trna synthetase
L6178_RS10665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L6178_RS10685	COG0017	Asparaginyl-tRNA synthetase
L6178_RS10705	COG1674	ftsk spoiiie
L6178_RS10775	COG1929	Belongs to the glycerate kinase type-1 family
L6178_RS10780	COG0471	metal ion transport
L6178_RS10785	COG0745	RESPONSE REGULATOR receiver
L6178_RS10790	COG5002	protein histidine kinase activity
L6178_RS10790	COG3850	Histidine kinase
L6178_RS10805	COG0733	neurotransmitter:sodium symporter activity
L6178_RS10830	COG2610	gluconate transmembrane transporter activity
L6178_RS10835	COG1454	alcohol dehydrogenase
L6178_RS10840	COG1794	racemase activity, acting on amino acids and derivatives
L6178_RS10850	COG0456	acetyltransferase
L6178_RS10865	COG1131	(ABC) transporter
L6178_RS10880	COG0546	phosphoglycolate phosphatase activity
L6178_RS10900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6178_RS10915	COG0768	penicillin binding
L6178_RS10920	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L6178_RS10925	COG0204	Acyl-transferase
L6178_RS10930	COG1272	protein, Hemolysin III
L6178_RS10940	COG0805	protein transport
L6178_RS10950	COG1307	EDD domain protein, DegV family
L6178_RS10955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L6178_RS10960	COG1999	signal sequence binding
L6178_RS10965	COG0071	Belongs to the small heat shock protein (HSP20) family
L6178_RS10970	COG0367	asparagine synthase
L6178_RS10985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6178_RS10990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6178_RS11025	COG0668	transmembrane transport
L6178_RS11030	COG2203	Gaf domain
L6178_RS11030	COG4585	Histidine kinase
L6178_RS11035	COG2197	response regulator
L6178_RS11045	COG1064	alcohol dehydrogenase
L6178_RS11100	COG0517	IMP dehydrogenase activity
L6178_RS11100	COG1125	glycine betaine transport
L6178_RS11105	COG1174	glycine betaine transport
L6178_RS11140	COG1253	flavin adenine dinucleotide binding
L6178_RS11145	COG1012	belongs to the aldehyde dehydrogenase family
L6178_RS11150	COG5506	Protein of unknown function (DUF1694)
L6178_RS11165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6178_RS11170	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L6178_RS11175	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L6178_RS11180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6178_RS11185	COG0456	acetyltransferase
L6178_RS11190	COG3829	transcription factor binding
L6178_RS11195	COG1509	lysine 2,3-aminomutase activity
L6178_RS11235	COG4326	sporulation control protein
L6178_RS11240	COG0671	phosphoesterase, PA-phosphatase related
L6178_RS11245	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L6178_RS11250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6178_RS11280	COG1715	Restriction endonuclease
L6178_RS11280	COG1787	Restriction endonuclease
L6178_RS11370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6178_RS11410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6178_RS11410	COG4499	WXG100 protein secretion system (Wss), protein YukC
L6178_RS11420	COG2814	Major facilitator Superfamily
L6178_RS11425	COG4841	protein insertion into membrane
L6178_RS11430	COG0372	Belongs to the citrate synthase family
L6178_RS11435	COG2079	MmgE PrpD family protein
L6178_RS11440	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L6178_RS11445	COG1960	acyl-CoA dehydrogenase activity
L6178_RS11450	COG2084	Dehydrogenase
L6178_RS11460	COG1280	lysine exporter protein (LysE YggA)
L6178_RS11465	COG1024	Enoyl-CoA hydratase
L6178_RS11480	COG0420	3'-5' exonuclease activity
L6178_RS11485	COG0419	ATPase involved in DNA repair
L6178_RS11510	COG2223	nitrite transmembrane transporter activity
L6178_RS11515	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_RS11520	COG1169	isochorismate synthase
L6178_RS11525	COG1021	2,3-dihydroxybenzoate-AMP ligase
L6178_RS11530	COG1535	isochorismatase
L6178_RS11530	COG3433	isochorismatase activity
L6178_RS11535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L6178_RS11540	COG3251	PFAM MbtH domain protein
L6178_RS11545	COG2814	Major facilitator Superfamily
L6178_RS11560	COG0776	regulation of translation
L6178_RS11570	COG2318	DinB family
L6178_RS11580	COG1115	amino acid carrier protein
L6178_RS11595	COG2329	Antibiotic biosynthesis monooxygenase
L6178_RS11600	COG1187	pseudouridine synthase activity
L6178_RS11605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6178_RS11620	COG0596	Alpha beta hydrolase
L6178_RS11625	COG2814	Major facilitator Superfamily
L6178_RS11645	COG2226	methyltransferase
L6178_RS11690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_RS11725	COG1247	-acetyltransferase
L6178_RS11755	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L6178_RS11765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_RS11775	COG1278	Cold shock
L6178_RS11790	COG0010	Belongs to the arginase family
L6178_RS11795	COG0561	phosphatase activity
L6178_RS11840	COG0583	DNA-binding transcription factor activity
L6178_RS11845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6178_RS11860	COG0583	DNA-binding transcription factor activity
L6178_RS11865	COG2258	MOSC domain
L6178_RS11880	COG1132	(ABC) transporter
L6178_RS11885	COG1132	(ABC) transporter
L6178_RS11905	COG1396	sequence-specific DNA binding
L6178_RS11930	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
L6178_RS11935	COG1595	DNA-templated transcription, initiation
L6178_RS11960	COG1649	PFAM Uncharacterised BCR, COG1649
L6178_RS11985	COG2971	BadF BadG BcrA BcrD
L6178_RS11990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L6178_RS11995	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L6178_RS12015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_RS12045	COG1309	transcriptional regulator
L6178_RS12060	COG1136	(ABC) transporter
L6178_RS12060	COG0577	efflux transmembrane transporter activity
L6178_RS12065	COG0500	methyltransferase
L6178_RS12065	COG3615	Tellurite resistance protein tehB
L6178_RS12075	COG2226	methyltransferase
L6178_RS12080	COG3961	Belongs to the TPP enzyme family
L6178_RS12085	COG1846	Transcriptional regulator
L6178_RS12125	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6178_RS12140	COG1595	DNA-templated transcription, initiation
L6178_RS12150	COG0768	penicillin binding
L6178_RS12160	COG2367	Beta-lactamase
L6178_RS12165	COG0671	phosphoesterase, PA-phosphatase related
L6178_RS12170	COG1609	Transcriptional regulator
L6178_RS12175	COG2814	Major facilitator Superfamily
L6178_RS12180	COG0673	inositol 2-dehydrogenase activity
L6178_RS12190	COG1012	belongs to the aldehyde dehydrogenase family
L6178_RS12205	COG0191	fructose-bisphosphate aldolase activity
L6178_RS12210	COG3718	enzyme involved in inositol metabolism
L6178_RS12235	COG0457	Tetratricopeptide repeat
L6178_RS12240	COG1476	TRANSCRIPTIONal
L6178_RS12255	COG1876	peptidase activity
L6178_RS12275	COG1309	transcriptional regulator
L6178_RS12280	COG0488	(ABC) transporter
L6178_RS12295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_RS12310	COG1252	NADH dehydrogenase
L6178_RS12315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6178_RS12330	COG1131	(ABC) transporter
L6178_RS12340	COG1309	transcriptional regulator
L6178_RS12355	COG1960	acyl-CoA dehydrogenase activity
L6178_RS12360	COG0439	Biotin carboxylase
L6178_RS12365	COG0511	ligase activity, forming carbon-carbon bonds
L6178_RS12370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L6178_RS12375	COG1024	Enoyl-CoA hydratase
L6178_RS12380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L6178_RS12385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6178_RS12395	COG1247	-acetyltransferase
L6178_RS12400	COG0572	uridine kinase
L6178_RS12410	COG2318	DinB family
L6178_RS12415	COG1686	Belongs to the peptidase S11 family
L6178_RS12440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L6178_RS12480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6178_RS12480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6178_RS12505	COG2814	Major facilitator Superfamily
L6178_RS12525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6178_RS12545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6178_RS12560	COG1063	alcohol dehydrogenase
L6178_RS12575	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L6178_RS12580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L6178_RS12595	COG3773	Cell wall hydrolase
L6178_RS12605	COG0745	RESPONSE REGULATOR receiver
L6178_RS12635	COG1136	(ABC) transporter
L6178_RS12660	COG0460	homoserine dehydrogenase
L6178_RS12665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6178_RS12675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L6178_RS12740	COG2124	cytochrome p450
L6178_RS12775	COG0561	phosphatase activity
L6178_RS12785	COG0768	penicillin binding
L6178_RS12790	COG1819	glycosyl
L6178_RS12795	COG1794	racemase activity, acting on amino acids and derivatives
L6178_RS12805	COG1122	ATPase activity
L6178_RS12820	COG2205	protein histidine kinase activity
L6178_RS12830	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6178_RS12835	COG0604	alcohol dehydrogenase
L6178_RS12840	COG0768	penicillin binding
L6178_RS12850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6178_RS12885	COG0693	protein deglycase activity
L6178_RS12915	COG2814	Major facilitator Superfamily
L6178_RS12930	COG0584	glycerophosphoryl diester phosphodiesterase
L6178_RS12950	COG0697	spore germination
L6178_RS12980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6178_RS12990	COG2223	nitrite transmembrane transporter activity
L6178_RS13005	COG2816	NAD+ diphosphatase activity
L6178_RS13010	COG0592	DNA-directed DNA polymerase activity
L6178_RS13015	COG1051	belongs to the nudix hydrolase family
L6178_RS13050	COG3878	Protein conserved in bacteria
L6178_RS13100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L6178_RS13115	COG0322	excinuclease ABC activity
L6178_RS13160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6178_RS13185	COG1011	Hydrolase
L6178_RS13205	COG0076	glutamate decarboxylase activity
L6178_RS13220	COG1523	belongs to the glycosyl hydrolase 13 family
L6178_RS13225	COG3227	Zinc metalloprotease (Elastase)
L6178_RS13245	COG0201	protein transport
L6178_RS13255	COG0697	spore germination
L6178_RS13260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6178_RS13290	COG4129	membrane
L6178_RS13295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_RS13310	COG2959	enzyme of heme biosynthesis
L6178_RS13330	COG3483	tryptophan 2,3-dioxygenase activity
L6178_RS13335	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
L6178_RS13340	COG3844	kynureninase activity
L6178_RS13345	COG1309	transcriptional regulator
L6178_RS13375	COG3284	Transcriptional regulator
L6178_RS13395	COG1349	DNA-binding transcription factor activity
L6178_RS13415	COG1959	2 iron, 2 sulfur cluster binding
L6178_RS13430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6178_RS13435	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6178_RS13440	COG0022	dehydrogenase e1 component
L6178_RS13445	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6178_RS13455	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_RS13460	COG0456	acetyltransferase
L6178_RS13460	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6178_RS13490	COG4176	ABC-type proline glycine betaine transport system permease component
L6178_RS13495	COG0517	IMP dehydrogenase activity
L6178_RS13495	COG4175	Glycine betaine
L6178_RS13520	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
L6178_RS13525	COG2153	protein acetylation
L6178_RS13530	COG3397	chitin binding
L6178_RS13545	COG2205	protein histidine kinase activity
L6178_RS13570	COG0658	competence protein
L6178_RS13570	COG2333	competence protein COMEC
L6178_RS13620	COG3973	AAA domain
L6178_RS13635	COG2105	PFAM AIG2 family protein
L6178_RS13640	COG0514	ATP-dependent DNA helicase (RecQ)
L6178_RS13660	COG4637	Psort location Cytoplasmic, score
L6178_RS13685	COG3397	chitin binding
L6178_RS13700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L6178_RS13705	COG1115	amino acid carrier protein
L6178_RS13710	COG1012	belongs to the aldehyde dehydrogenase family
L6178_RS13715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L6178_RS13725	COG3938	Belongs to the proline racemase family
L6178_RS13730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6178_RS13770	COG0586	Pfam SNARE associated Golgi protein
L6178_RS13785	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L6178_RS13790	COG0519	Catalyzes the synthesis of GMP from XMP
L6178_RS13795	COG4166	transmembrane transport
L6178_RS13805	COG4948	Mandelate Racemase Muconate Lactonizing
L6178_RS13850	COG2936	dipeptidyl-peptidase activity
L6178_RS13855	COG5002	protein histidine kinase activity
L6178_RS13905	COG1307	EDD domain protein, DegV family
L6178_RS13925	COG2814	Major facilitator Superfamily
L6178_RS13935	COG1664	Polymer-forming cytoskeletal
L6178_RS13940	COG0789	Transcriptional regulator
L6178_RS13945	COG4533	DNA binding
L6178_RS13950	COG2814	Major facilitator Superfamily
L6178_RS13950	COG0477	Major facilitator Superfamily
L6178_RS13970	COG2261	transglycosylase associated protein
L6178_RS13985	COG2226	methyltransferase
L6178_RS14020	COG0436	Aminotransferase
L6178_RS14025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L6178_RS14030	COG5146	pantothenate kinase activity
L6178_RS14095	COG0628	permease
L6178_RS14110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6178_RS14115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6178_RS14120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6178_RS14125	COG1116	anion transmembrane transporter activity
L6178_RS14145	COG2816	NAD+ diphosphatase activity
L6178_RS14165	COG2746	aminoglycoside 3-N-acetyltransferase activity
L6178_RS14190	COG0697	spore germination
L6178_RS14195	COG2318	DinB family
L6178_RS14215	COG4912	Dna alkylation repair
L6178_RS14235	COG0861	Integral membrane protein TerC family
L6178_RS14240	COG1368	sulfuric ester hydrolase activity
L6178_RS14245	COG0488	(ABC) transporter
L6178_RS14260	COG1309	transcriptional regulator
L6178_RS14275	COG0287	Prephenate dehydrogenase
L6178_RS14280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L6178_RS14285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L6178_RS14290	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
L6178_RS14290	COG1605	Chorismate mutase
L6178_RS14325	COG3584	3D domain protein
L6178_RS14325	COG1388	LysM domain
L6178_RS14335	COG1595	DNA-templated transcription, initiation
L6178_RS14360	COG1879	ABC-type sugar transport system periplasmic component
L6178_RS14370	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6178_RS14380	COG2390	Transcriptional regulator
L6178_RS14415	COG2329	Antibiotic biosynthesis monooxygenase
L6178_RS14435	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6178_RS14445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L6178_RS14450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6178_RS14455	COG4187	Peptidase family M20/M25/M40
L6178_RS14460	COG1414	Transcriptional regulator
L6178_RS14465	COG0833	amino acid
L6178_RS14470	COG1690	Belongs to the RtcB family
L6178_RS14480	COG1785	Belongs to the alkaline phosphatase family
L6178_RS14490	COG3655	Transcriptional regulator
L6178_RS14505	COG4377	Putative membrane peptidase family (DUF2324)
L6178_RS14515	COG3279	Response regulator of the LytR AlgR family
L6178_RS14525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_RS14530	COG0346	lactoylglutathione lyase activity
L6178_RS14550	COG0714	Associated with various cellular activities
L6178_RS14575	COG0463	Glycosyl transferase, family 2
L6178_RS14595	COG0463	Glycosyl transferase, family 2
L6178_RS14605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L6178_RS14610	COG0753	catalase activity
L6178_RS14620	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L6178_RS14645	COG0714	Associated with various cellular activities
L6178_RS14655	COG0778	Nitroreductase
L6178_RS14660	COG1846	Transcriptional regulator
L6178_RS14695	COG1725	Transcriptional regulator
L6178_RS14705	COG0577	efflux transmembrane transporter activity
L6178_RS14705	COG1136	(ABC) transporter
L6178_RS14730	COG2207	Transcriptional regulator
L6178_RS14735	COG0456	acetyltransferase
L6178_RS14755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6178_RS14775	COG0642	Histidine kinase
L6178_RS14780	COG0745	RESPONSE REGULATOR receiver
L6178_RS14785	COG0596	Alpha beta hydrolase
L6178_RS14815	COG0730	response to heat
L6178_RS14825	COG0833	amino acid
L6178_RS14835	COG4335	DNA alkylation repair
L6178_RS14875	COG0768	penicillin binding
L6178_RS14885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L6178_RS14920	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L6178_RS14925	COG1414	Transcriptional regulator
L6178_RS14940	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6178_RS14945	COG0640	Transcriptional regulator
L6178_RS14955	COG1960	acyl-CoA dehydrogenase activity
L6178_RS14975	COG3314	Sporulation integral membrane protein YlbJ
L6178_RS14990	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
L6178_RS15005	COG3848	Pyruvate phosphate dikinase
L6178_RS15005	COG0574	Belongs to the PEP-utilizing enzyme family
L6178_RS15010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_RS15025	COG5577	PFAM Coat F domain
L6178_RS15030	COG3403	YqcI/YcgG family
L6178_RS15035	COG1280	lysine exporter protein (LysE YggA)
L6178_RS15070	COG1063	alcohol dehydrogenase
L6178_RS15085	COG1027	Aspartate ammonia-lyase
L6178_RS15090	COG0252	asparaginase activity
L6178_RS15095	COG1396	sequence-specific DNA binding
L6178_RS15105	COG0322	excinuclease ABC activity
L6178_RS15110	COG0531	amino acid
L6178_RS15115	COG1114	Component of the transport system for branched-chain amino acids
L6178_RS15120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6178_RS15130	COG0281	malic enzyme
L6178_RS15145	COG0531	amino acid
L6178_RS15155	COG0784	Response regulator, receiver
L6178_RS15165	COG2066	Belongs to the glutaminase family
L6178_RS15200	COG0737	Belongs to the 5'-nucleotidase family
L6178_RS15205	COG0753	catalase activity
L6178_RS15210	COG2267	carboxylic ester hydrolase activity
L6178_RS15215	COG1335	isochorismatase
L6178_RS15235	COG0583	DNA-binding transcription factor activity
L6178_RS15285	COG0415	Belongs to the DNA photolyase family
L6178_RS15290	COG0288	reversible hydration of carbon dioxide
L6178_RS15300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L6178_RS15305	COG5609	conserved protein (DUF2294)
L6178_RS15320	COG1575	Belongs to the MenA family. Type 1 subfamily
L6178_RS15325	COG2267	carboxylic ester hydrolase activity
L6178_RS15330	COG0803	Belongs to the bacterial solute-binding protein 9 family
L6178_RS15335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6178_RS15340	COG1121	(ABC) transporter
L6178_RS15370	COG0798	PFAM Bile acid sodium symporter
L6178_RS15375	COG0346	lactoylglutathione lyase activity
L6178_RS15380	COG0640	Transcriptional regulator
L6178_RS15395	COG0443	Heat shock 70 kDa protein
L6178_RS15410	COG1522	sequence-specific DNA binding
L6178_RS15425	COG0346	lactoylglutathione lyase activity
L6178_RS15500	COG2814	Major facilitator Superfamily
L6178_RS15525	COG0745	RESPONSE REGULATOR receiver
L6178_RS15530	COG3850	Histidine kinase
L6178_RS15530	COG5002	protein histidine kinase activity
L6178_RS15555	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L6178_RS15575	COG1476	TRANSCRIPTIONal
L6178_RS15590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_RS15595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6178_RS15605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6178_RS15610	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L6178_RS15625	COG1136	(ABC) transporter
L6178_RS15630	COG0577	efflux transmembrane transporter activity
L6178_RS15645	COG3850	Histidine kinase
L6178_RS15645	COG5002	protein histidine kinase activity
L6178_RS15655	COG2364	Membrane
L6178_RS15660	COG1846	Transcriptional regulator
L6178_RS15670	COG2808	Putative FMN-binding domain
L6178_RS15675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_RS15680	COG2271	Major facilitator Superfamily
L6178_RS15685	COG1556	Lactate utilization protein
L6178_RS15690	COG1139	Iron-sulfur cluster binding protein
L6178_RS15700	COG0583	DNA-binding transcription factor activity
L6178_RS15710	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6178_RS15735	COG0738	Major facilitator superfamily
L6178_RS15740	COG0673	inositol 2-dehydrogenase activity
L6178_RS15745	COG0561	phosphatase activity
L6178_RS15755	COG1609	Transcriptional regulator
L6178_RS15760	COG0457	Tetratricopeptide repeat
L6178_RS15780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L6178_RS15810	COG0534	Mate efflux family protein
L6178_RS15830	COG2814	Major facilitator Superfamily
L6178_RS15835	COG1309	transcriptional regulator
L6178_RS15850	COG0814	amino acid
L6178_RS15855	COG1760	l-serine dehydratase
L6178_RS15860	COG1760	l-serine dehydratase
L6178_RS15870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L6178_RS15875	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
L6178_RS15885	COG1335	isochorismatase
L6178_RS15890	COG1522	sequence-specific DNA binding
L6178_RS15895	COG0531	amino acid
L6178_RS15915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L6178_RS15935	COG1595	DNA-templated transcription, initiation
L6178_RS15950	COG0662	Cupin 2, conserved barrel domain protein
L6178_RS15955	COG2207	Transcriptional regulator
L6178_RS15955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6178_RS16005	COG0477	Major facilitator Superfamily
L6178_RS16015	COG1846	Transcriptional regulator
L6178_RS16020	COG2814	Major facilitator Superfamily
L6178_RS16030	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6178_RS16035	COG1131	(ABC) transporter
L6178_RS16055	COG2076	Multidrug Resistance protein
L6178_RS16060	COG1309	transcriptional regulator
L6178_RS16070	COG2031	fatty acid transporter
L6178_RS16080	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6178_RS16110	COG1122	ATPase activity
L6178_RS16115	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L6178_RS16130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L6178_RS16135	COG1288	antiporter activity
L6178_RS16140	COG2356	endonuclease I
L6178_RS16155	COG3620	sequence-specific DNA binding
L6178_RS16160	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L6178_RS16165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L6178_RS16170	COG0124	histidyl-tRNA synthetase
L6178_RS16185	COG1733	regulation of RNA biosynthetic process
L6178_RS16190	COG0778	Nitroreductase
L6178_RS16210	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_RS16220	COG1131	(ABC) transporter
L6178_RS16245	COG1011	Hydrolase
L6178_RS16255	COG2365	Tyrosine phosphatase family
L6178_RS16280	COG0346	lactoylglutathione lyase activity
L6178_RS16285	COG1940	carbohydrate kinase activity
L6178_RS16290	COG0738	Major facilitator superfamily
L6178_RS16295	COG0110	maltose O-acetyltransferase activity
L6178_RS16305	COG1136	(ABC) transporter
L6178_RS16305	COG0577	efflux transmembrane transporter activity
L6178_RS16320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L6178_RS16325	COG0628	permease
L6178_RS16345	COG2226	methyltransferase
L6178_RS16355	COG0477	Major facilitator Superfamily
L6178_RS16385	COG1253	flavin adenine dinucleotide binding
L6178_RS16390	COG0789	Transcriptional regulator
L6178_RS16395	COG0697	spore germination
L6178_RS16400	COG1357	PFAM Pentapeptide repeats (8 copies)
L6178_RS16405	COG3813	Protein conserved in bacteria
L6178_RS16410	COG2706	6-phosphogluconolactonase activity
L6178_RS16415	COG1070	Carbohydrate kinase
L6178_RS16425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L6178_RS16430	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L6178_RS16440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L6178_RS16445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L6178_RS16450	COG0604	alcohol dehydrogenase
L6178_RS16455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6178_RS16465	COG0604	alcohol dehydrogenase
L6178_RS16465	COG3321	synthase
L6178_RS16470	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_RS16495	COG0656	L-ascorbic acid biosynthetic process
L6178_RS16500	COG2814	Major facilitator Superfamily
L6178_RS16515	COG0346	lactoylglutathione lyase activity
L6178_RS16520	COG0814	amino acid
L6178_RS16545	COG1393	Belongs to the ArsC family
L6178_RS16550	COG1733	regulation of RNA biosynthetic process
L6178_RS16555	COG2188	Transcriptional regulator
L6178_RS16565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L6178_RS16570	COG1733	regulation of RNA biosynthetic process
L6178_RS16575	COG1733	regulation of RNA biosynthetic process
L6178_RS16590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_RS16610	COG0384	phenazine biosynthesis protein PhzF
L6178_RS16620	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_RS16630	COG0318	PFAM AMP-dependent synthetase and ligase
L6178_RS16640	COG1733	regulation of RNA biosynthetic process
L6178_RS16670	COG1191	sigma factor activity
L6178_RS16685	COG1309	transcriptional regulator
L6178_RS16705	COG3152	Membrane
L6178_RS16730	COG1151	hydroxylamine reductase activity
L6178_RS16740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_RS16745	COG3409	Peptidoglycan-binding domain 1 protein
L6178_RS16745	COG3757	hydrolase, family 25
L6178_RS16780	COG2072	flavoprotein involved in K transport
L6178_RS16820	COG1113	amino acid transport
L6178_RS16825	COG2814	Major facilitator Superfamily
L6178_RS16855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6178_RS16860	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6178_RS16885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_RS16890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_RS16895	COG3739	integral membrane protein
L6178_RS16900	COG0384	phenazine biosynthesis protein PhzF
L6178_RS16930	COG0583	DNA-binding transcription factor activity
L6178_RS16950	COG1193	negative regulation of DNA recombination
L6178_RS16970	COG1164	Oligoendopeptidase f
L6178_RS16975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6178_RS17005	COG0584	glycerophosphoryl diester phosphodiesterase
L6178_RS17030	COG0640	Transcriptional regulator
L6178_RS17035	COG0604	alcohol dehydrogenase
L6178_RS17055	COG2808	Putative FMN-binding domain
L6178_RS17060	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6178_RS17070	COG0385	Bile acid
L6178_RS17075	COG0277	FAD linked oxidase domain protein
L6178_RS17105	COG1216	Glycosyl transferase, family 2
L6178_RS17110	COG1024	Enoyl-CoA hydratase
L6178_RS17120	COG1285	pathogenesis
L6178_RS17135	COG2514	catechol 2,3-dioxygenase activity
L6178_RS17140	COG2720	vancomycin resistance protein
L6178_RS17180	COG0716	FMN binding
L6178_RS17210	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_RS17220	COG0165	Argininosuccinate lyase
L6178_RS17235	COG4145	pantothenate transmembrane transporter activity
L6178_RS17245	COG1012	belongs to the aldehyde dehydrogenase family
L6178_RS17250	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_RS17260	COG1657	PFAM Prenyltransferase squalene oxidase
L6178_RS17265	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
L6178_RS17270	COG2962	Rard protein
L6178_RS17275	COG3326	Membrane
L6178_RS17290	COG0489	protein tyrosine kinase activity
L6178_RS17300	COG0314	molybdopterin synthase activity
L6178_RS17305	COG0303	'Molybdopterin
L6178_RS17310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6178_RS17315	COG2116	formate transmembrane transporter activity
L6178_RS17325	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L6178_RS17330	COG5609	conserved protein (DUF2294)
L6178_RS17335	COG2427	Protein of unknown function (DUF1641)
L6178_RS17340	COG3383	formate dehydrogenase (NAD+) activity
L6178_RS17350	COG0697	spore germination
L6178_RS17390	COG2226	methyltransferase
L6178_RS17395	COG4166	transmembrane transport
L6178_RS17400	COG4166	transmembrane transport
L6178_RS17405	COG4166	transmembrane transport
L6178_RS17415	COG1316	TRANSCRIPTIONal
L6178_RS17425	COG1595	DNA-templated transcription, initiation
L6178_RS17445	COG1131	(ABC) transporter
L6178_RS17455	COG0673	inositol 2-dehydrogenase activity
L6178_RS17460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L6178_RS17465	COG0187	DNA topoisomerase II activity
L6178_RS17470	COG1832	CoA-binding protein
L6178_RS17475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6178_RS17480	COG0745	RESPONSE REGULATOR receiver
L6178_RS17495	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L6178_RS17500	COG4841	protein insertion into membrane
L6178_RS17505	COG0824	Thioesterase
L6178_RS17535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6178_RS17545	COG2274	protein secretion by the type I secretion system
L6178_RS17550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L6178_RS17590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6178_RS17605	COG0183	Belongs to the thiolase family
L6178_RS17610	COG0318	PFAM AMP-dependent synthetase and ligase
L6178_RS17615	COG1268	BioY protein
L6178_RS17620	COG0318	PFAM AMP-dependent synthetase and ligase
L6178_RS17670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_RS17680	COG5002	protein histidine kinase activity
L6178_RS17685	COG0400	carboxylic ester hydrolase activity
L6178_RS17690	COG0346	lactoylglutathione lyase activity
L6178_RS17695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6178_RS17700	COG0069	glutamate synthase activity
L6178_RS17705	COG1902	pentaerythritol trinitrate reductase activity
L6178_RS17710	COG1329	Transcriptional regulator
L6178_RS17715	COG0010	Belongs to the arginase family
L6178_RS17740	COG2226	methyltransferase
L6178_RS17775	COG4846	Membrane protein involved in cytochrome C biogenesis
L6178_RS17780	COG0785	Cytochrome C biogenesis protein
L6178_RS17790	COG0583	DNA-binding transcription factor activity
L6178_RS17795	COG1380	Effector of murein hydrolase LrgA
L6178_RS17800	COG1346	cytolysis
L6178_RS17825	COG3409	Peptidoglycan-binding domain 1 protein
L6178_RS17825	COG5632	N-Acetylmuramoyl-L-alanine amidase
L6178_RS17840	COG1132	(ABC) transporter
L6178_RS17845	COG1132	(ABC) transporter
L6178_RS17875	COG3639	organic phosphonate transmembrane transporter activity
L6178_RS17880	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
L6178_RS17900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L6178_RS17920	COG1695	Transcriptional regulator
L6178_RS17965	COG5632	N-Acetylmuramoyl-L-alanine amidase
L6178_RS17965	COG1388	LysM domain
L6178_RS17965	COG3409	Peptidoglycan-binding domain 1 protein
L6178_RS17970	COG4824	toxin secretion phage lysis holin
L6178_RS18125	COG1595	DNA-templated transcription, initiation
L6178_RS18170	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
L6178_RS18255	COG1396	sequence-specific DNA binding
L6178_RS18280	COG0174	glutamine synthetase
L6178_RS18285	COG0789	Transcriptional regulator
L6178_RS18290	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
L6178_RS18300	COG2860	membrane
L6178_RS18305	COG0464	growth
L6178_RS18335	COG1388	LysM domain
L6178_RS18335	COG3584	3D domain protein
L6178_RS18340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6178_RS18340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6178_RS18340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6178_RS18345	COG1105	Belongs to the carbohydrate kinase PfkB family
L6178_RS18350	COG1349	DNA-binding transcription factor activity
L6178_RS18360	COG2322	membrane
L6178_RS18370	COG1113	amino acid transport
L6178_RS18385	COG1408	metallophosphoesterase
L6178_RS18390	COG2116	formate transmembrane transporter activity
L6178_RS18400	COG2217	Heavy metal translocating P-type atpase
L6178_RS18405	COG2608	mercury ion transmembrane transporter activity
L6178_RS18410	COG1937	Protein conserved in bacteria
L6178_RS18420	COG2819	hydrolase of the alpha beta superfamily
L6178_RS18425	COG1120	ATPase activity
L6178_RS18430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_RS18435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_RS18445	COG0708	Exodeoxyribonuclease III
L6178_RS18450	COG2169	Transcriptional regulator
L6178_RS18455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L6178_RS18460	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
L6178_RS18470	COG2364	Membrane
L6178_RS18485	COG2267	carboxylic ester hydrolase activity
L6178_RS18490	COG0346	lactoylglutathione lyase activity
L6178_RS18495	COG3300	MHYT domain
L6178_RS18495	COG5001	Diguanylate cyclase
L6178_RS18510	COG1346	cytolysis
L6178_RS18515	COG1380	Effector of murein hydrolase LrgA
L6178_RS18520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6178_RS18525	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6178_RS18525	COG0596	Alpha beta hydrolase
L6178_RS18530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6178_RS18550	COG1404	Belongs to the peptidase S8 family
L6178_RS18555	COG3773	Cell wall hydrolase
L6178_RS18560	COG0562	UDP-galactopyranose mutase
L6178_RS18565	COG1368	sulfuric ester hydrolase activity
L6178_RS18570	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6178_RS18580	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
L6178_RS18605	COG1131	(ABC) transporter
L6178_RS18625	COG4550	Control of competence regulator ComK, YlbF/YmcA
L6178_RS18630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L6178_RS18635	COG1013	pyruvate-flavodoxin oxidoreductase activity
L6178_RS18640	COG0674	pyruvate-flavodoxin oxidoreductase activity
L6178_RS18640	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L6178_RS18650	COG2359	stage V sporulation protein S
L6178_RS18655	COG1692	metallophosphoesterase
L6178_RS18680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L6178_RS18685	COG1426	Protein conserved in bacteria
L6178_RS18700	COG0300	oxidoreductase activity
L6178_RS18705	COG0612	Peptidase, M16
L6178_RS18710	COG0612	Peptidase, M16
L6178_RS18725	COG3845	ABC transporter
L6178_RS18730	COG1744	ABC transporter substrate-binding protein PnrA-like
L6178_RS18735	COG2188	Transcriptional regulator
L6178_RS18740	COG1674	ftsk spoiiie
L6178_RS18750	COG0740	serine-type endopeptidase activity
L6178_RS18765	COG0527	aspartate kinase activity
L6178_RS18770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6178_RS18775	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L6178_RS18780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6178_RS18785	COG1873	PFAM PRC-barrel domain
L6178_RS18790	COG0612	Peptidase, M16
L6178_RS18795	COG0726	polysaccharide deacetylase
L6178_RS18810	COG0196	riboflavin kinase activity
L6178_RS18815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L6178_RS18825	COG1550	Protein conserved in bacteria
L6178_RS18835	COG1358	cellular component organization or biogenesis
L6178_RS18840	COG2740	Nucleic-acid-binding protein implicated in transcription termination
L6178_RS18845	COG0195	Participates in both transcription termination and antitermination
L6178_RS18865	COG0750	zinc metalloprotease
L6178_RS18875	COG4589	Belongs to the CDS family
L6178_RS18880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L6178_RS18890	COG0528	UMP kinase activity
L6178_RS18920	COG4974	Belongs to the 'phage' integrase family
L6178_RS18930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L6178_RS18940	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L6178_RS18980	COG1837	Belongs to the UPF0109 family
L6178_RS18990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L6178_RS19000	COG0552	protein localization to endoplasmic reticulum
L6178_RS19005	COG1196	nuclear chromosome segregation
L6178_RS19015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6178_RS19020	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_RS19025	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L6178_RS19040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L6178_RS19045	COG1461	Dihydroxyacetone kinase
L6178_RS19050	COG1302	Protein conserved in bacteria
L6178_RS19065	COG1564	THIamine pyrophosphokinase
L6178_RS19070	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L6178_RS19075	COG1162	GTPase activity
L6178_RS19080	COG0515	serine threonine protein kinase
L6178_RS19080	COG2815	serine threonine protein kinase
L6178_RS19085	COG0631	protein serine/threonine phosphatase activity
L6178_RS19095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L6178_RS19095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L6178_RS19105	COG0242	peptide deformylase activity
L6178_RS19110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L6178_RS19115	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L6178_RS19135	COG1561	YicC-like family, N-terminal region
L6178_RS19140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L6178_RS19150	COG0006	proline dipeptidase activity
L6178_RS19165	COG3069	C4-dicarboxylate transmembrane transporter activity
L6178_RS19230	COG0564	pseudouridine synthase activity
L6178_RS19250	COG3599	regulation of cell shape
L6178_RS19255	COG2302	S4 RNA-binding domain
L6178_RS19260	COG0762	integral membrane protein
L6178_RS19270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L6178_RS19275	COG1496	oxidoreductase activity
L6178_RS19280	COG1873	PFAM PRC-barrel domain
L6178_RS19285	COG1191	sigma factor activity
L6178_RS19290	COG1191	sigma factor activity
L6178_RS19300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L6178_RS19305	COG0849	cell division
L6178_RS19310	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L6178_RS19315	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L6178_RS19325	COG0772	Belongs to the SEDS family
L6178_RS19340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L6178_RS19345	COG0768	penicillin binding
L6178_RS19350	COG0768	penicillin binding
L6178_RS19355	COG4839	cell division protein FtsL
L6178_RS19370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L6178_RS19385	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L6178_RS19390	COG1399	metal-binding, possibly nucleic acid-binding protein
L6178_RS19440	COG4824	toxin secretion phage lysis holin
L6178_RS19540	COG4626	Terminase
L6178_RS19540	COG1802	Transcriptional regulator
L6178_RS19565	COG0582	viral genome integration into host DNA
L6178_RS19630	COG0756	dUTP diphosphatase activity
L6178_RS19645	COG1191	sigma factor activity
L6178_RS19670	COG1484	DNA-dependent DNA replication
L6178_RS19700	COG1396	sequence-specific DNA binding
L6178_RS19715	COG1396	sequence-specific DNA binding
L6178_RS19730	COG0582	viral genome integration into host DNA
L6178_RS19740	COG3480	Lon protease (S16) C-terminal proteolytic domain
L6178_RS19745	COG1752	Esterase of the alpha-beta hydrolase superfamily
L6178_RS19750	COG3314	Sporulation integral membrane protein YlbJ
L6178_RS19760	COG0742	ribosomal rna small subunit methyltransferase
L6178_RS19775	COG3679	Belongs to the UPF0342 family
L6178_RS19780	COG0406	alpha-ribazole phosphatase activity
L6178_RS19795	COG2340	Cysteine-rich secretory protein family
L6178_RS19810	COG3336	cytochrome c oxidase
L6178_RS19845	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L6178_RS19850	COG0772	Belongs to the SEDS family
L6178_RS19860	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L6178_RS19865	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L6178_RS19875	COG4896	Protein conserved in bacteria
L6178_RS19890	COG1217	gtp-binding protein TYPA
L6178_RS19900	COG0483	inositol monophosphate 1-phosphatase activity
L6178_RS19920	COG1982	Orn Lys Arg decarboxylase major
L6178_RS19965	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6178_RS19970	COG0022	dehydrogenase e1 component
L6178_RS19975	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6178_RS19985	COG0242	peptide deformylase activity
L6178_RS19990	COG0561	phosphatase activity
L6178_RS20000	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L6178_RS20005	COG0569	domain protein
L6178_RS20025	COG0583	DNA-binding transcription factor activity
L6178_RS20030	COG0517	IMP dehydrogenase activity
L6178_RS20040	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
L6178_RS20050	COG4703	Protein of unknown function (DUF1797)
L6178_RS20065	COG2200	EAL domain
L6178_RS20070	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_RS20075	COG1408	metallophosphoesterase
L6178_RS20085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L6178_RS20120	COG2814	Major facilitator Superfamily
L6178_RS20140	COG3209	COG3209 Rhs family protein
L6178_RS20150	COG2205	protein histidine kinase activity
L6178_RS20160	COG0436	Aminotransferase
L6178_RS20165	COG1609	Transcriptional regulator
L6178_RS20170	COG3833	ABC-type maltose transport systems, permease component
L6178_RS20175	COG1175	transmembrane transport
L6178_RS20180	COG2182	Extracellular solute-binding protein
L6178_RS20190	COG0366	Alpha amylase catalytic
L6178_RS20195	COG3842	ATPase activity
L6178_RS20235	COG0183	Belongs to the thiolase family
L6178_RS20270	COG1695	Transcriptional regulator
L6178_RS20275	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_RS20285	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L6178_RS20295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L6178_RS20300	COG0436	Aminotransferase
L6178_RS20320	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
L6178_RS20340	COG2199	diguanylate cyclase activity
L6178_RS20345	COG0778	Nitroreductase
L6178_RS20370	COG2190	(PTS) system
L6178_RS20370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6178_RS20370	COG1263	PTS System
L6178_RS20375	COG3711	transcriptional antiterminator
L6178_RS20385	COG2188	Transcriptional regulator
L6178_RS20395	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L6178_RS20420	COG1547	Domain of unknown function (DUF309)
L6178_RS20425	COG0456	acetyltransferase
L6178_RS20435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L6178_RS20440	COG4086	secreted protein
L6178_RS20445	COG0561	phosphatase activity
L6178_RS20450	COG0697	spore germination
L6178_RS20465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6178_RS20490	COG0733	neurotransmitter:sodium symporter activity
L6178_RS20510	COG1686	Belongs to the peptidase S11 family
L6178_RS20515	COG1725	Transcriptional regulator
L6178_RS20520	COG1131	(ABC) transporter
L6178_RS20535	COG1846	Transcriptional regulator
L6178_RS20550	COG0598	Magnesium transport protein CorA
L6178_RS20575	COG4974	Belongs to the 'phage' integrase family
L6178_RS20585	COG0735	belongs to the Fur family
L6178_RS20590	COG1300	Membrane
L6178_RS20610	COG0667	Aldo Keto reductase
L6178_RS20615	COG0656	L-ascorbic acid biosynthetic process
L6178_RS20620	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6178_RS20620	COG0456	acetyltransferase
L6178_RS20630	COG1525	nuclease
L6178_RS20630	COG4085	toxin activity
L6178_RS20630	COG0737	Belongs to the 5'-nucleotidase family
L6178_RS20640	COG0596	Alpha beta hydrolase
L6178_RS20645	COG2056	Na+-H+ antiporter family
L6178_RS20650	COG1609	Transcriptional regulator
L6178_RS20655	COG0456	acetyltransferase
L6178_RS20660	COG1073	alpha beta
L6178_RS20675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6178_RS20675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6178_RS20680	COG0307	riboflavin synthase, alpha
L6178_RS20705	COG4106	trans-aconitate 2-methyltransferase activity
L6178_RS20710	COG1073	alpha beta
L6178_RS20710	COG2226	methyltransferase
L6178_RS20725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6178_RS20735	COG1757	Na H antiporter
L6178_RS20740	COG0737	Belongs to the 5'-nucleotidase family
L6178_RS20750	COG1522	sequence-specific DNA binding
L6178_RS20770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L6178_RS20780	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L6178_RS20795	COG0300	oxidoreductase activity
L6178_RS20805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6178_RS20810	COG1760	l-serine dehydratase
L6178_RS20815	COG1760	l-serine dehydratase
L6178_RS20835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L6178_RS20845	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6178_RS20850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_RS20865	COG1376	ErfK ybiS ycfS ynhG family protein
L6178_RS20870	COG4129	membrane
L6178_RS20875	COG1126	abc transporter atp-binding protein
L6178_RS20880	COG0765	amino acid transport
L6178_RS20885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6178_RS20900	COG2816	NAD+ diphosphatase activity
L6178_RS20905	COG0772	Belongs to the SEDS family
L6178_RS20910	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6178_RS20915	COG0022	dehydrogenase e1 component
L6178_RS20920	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6178_RS20925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6178_RS20940	COG0280	phosphate acetyltransferase
L6178_RS20945	COG3829	transcription factor binding
L6178_RS20945	COG3290	protein histidine kinase activity
L6178_RS20955	COG0584	glycerophosphoryl diester phosphodiesterase
L6178_RS20960	COG3093	addiction module antidote protein HigA
L6178_RS20970	COG0745	RESPONSE REGULATOR receiver
L6178_RS20975	COG0750	zinc metalloprotease
L6178_RS20980	COG0497	DNA recombination
L6178_RS20990	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
L6178_RS21000	COG0142	geranyltranstransferase activity
L6178_RS21025	COG1302	Protein conserved in bacteria
L6178_RS21030	COG0439	Biotin carboxylase
L6178_RS21035	COG0511	ligase activity, forming carbon-carbon bonds
L6178_RS21080	COG3854	ATPases associated with a variety of cellular activities
L6178_RS21105	COG0006	proline dipeptidase activity
L6178_RS21120	COG3872	metal-dependent enzyme
L6178_RS21130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6178_RS21150	COG0095	Lipoate-protein ligase
L6178_RS21155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6178_RS21160	COG1609	Transcriptional regulator
L6178_RS21170	COG2076	Multidrug Resistance protein
L6178_RS21175	COG2076	Multidrug Resistance protein
L6178_RS21210	COG1131	(ABC) transporter
L6178_RS21215	COG1725	Transcriptional regulator
L6178_RS21245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6178_RS21300	COG4970	Tfp pilus assembly protein FimT
L6178_RS21310	COG1459	type II secretion system
L6178_RS21315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L6178_RS21365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L6178_RS21370	COG1410	methionine synthase
L6178_RS21370	COG0646	methionine synthase
L6178_RS21375	COG0646	methionine synthase
L6178_RS21375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L6178_RS21380	COG0626	cystathionine gamma-synthase activity
L6178_RS21385	COG0626	cystathionine gamma-synthase activity
L6178_RS21405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_RS21415	COG1940	carbohydrate kinase activity
L6178_RS21420	COG4483	Protein conserved in bacteria
L6178_RS21425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L6178_RS21430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L6178_RS21435	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L6178_RS21440	COG0704	Plays a role in the regulation of phosphate uptake
L6178_RS21450	COG0581	inorganic phosphate transmembrane transporter activity
L6178_RS21455	COG0573	inorganic phosphate transmembrane transporter activity
L6178_RS21460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L6178_RS21465	COG0768	penicillin binding
L6178_RS21470	COG0477	Major facilitator Superfamily
L6178_RS21475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6178_RS21500	COG0735	belongs to the Fur family
L6178_RS21505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6178_RS21510	COG1121	(ABC) transporter
L6178_RS21515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_RS21545	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L6178_RS21550	COG2384	SAM-dependent methyltransferase
L6178_RS21555	COG2010	Cytochrome c
L6178_RS21560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L6178_RS21565	COG0358	DNA primase activity
L6178_RS21575	COG0517	IMP dehydrogenase activity
L6178_RS21590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L6178_RS21595	COG0295	cytidine deaminase activity
L6178_RS21600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L6178_RS21610	COG1480	7TM receptor with intracellular HD hydrolase
L6178_RS21615	COG1702	phosphate starvation-inducible protein PhoH
L6178_RS21630	COG1610	YqeY-like protein
L6178_RS21635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L6178_RS21640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L6178_RS21645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L6178_RS21675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6178_RS21680	COG1733	regulation of RNA biosynthetic process
L6178_RS21705	COG1466	dna polymerase III delta subunit
L6178_RS21715	COG2333	competence protein COMEC
L6178_RS21715	COG0658	competence protein
L6178_RS21720	COG2131	deaminase
L6178_RS21725	COG1596	polysaccharide export
L6178_RS21725	COG1555	photosystem II stabilization
L6178_RS21730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6178_RS21735	COG2226	methyltransferase
L6178_RS21740	COG0799	negative regulation of ribosome biogenesis
L6178_RS21745	COG1713	HD superfamily hydrolase involved in NAD metabolism
L6178_RS21755	COG1534	Rna-binding protein
L6178_RS21765	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L6178_RS21770	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
L6178_RS21795	COG1595	DNA-templated transcription, initiation
L6178_RS21805	COG0778	Nitroreductase
L6178_RS21810	COG2357	RelA SpoT domain protein
L6178_RS21820	COG1785	Belongs to the alkaline phosphatase family
L6178_RS21830	COG2267	carboxylic ester hydrolase activity
L6178_RS21865	COG1404	Belongs to the peptidase S8 family
L6178_RS21870	COG3186	Phenylalanine-4-hydroxylase
L6178_RS21885	COG2259	Doxx family
L6178_RS21925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6178_RS21935	COG1012	belongs to the aldehyde dehydrogenase family
L6178_RS21935	COG1454	alcohol dehydrogenase
L6178_RS21940	COG0626	cystathionine gamma-synthase activity
L6178_RS21945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6178_RS21970	COG0768	penicillin binding
L6178_RS21985	COG0826	peptidase U32
L6178_RS21990	COG0826	peptidase U32
L6178_RS21995	COG4122	O-methyltransferase activity
L6178_RS22000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L6178_RS22020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6178_RS22030	COG0628	permease
L6178_RS22050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L6178_RS22060	COG0482	sulfurtransferase activity
L6178_RS22065	COG1104	cysteine desulfurase activity
L6178_RS22070	COG1959	2 iron, 2 sulfur cluster binding
L6178_RS22075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L6178_RS22085	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L6178_RS22110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L6178_RS22120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L6178_RS22120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L6178_RS22125	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L6178_RS22130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6178_RS22130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6178_RS22140	COG2244	polysaccharide biosynthetic process
L6178_RS22145	COG2323	membrane
L6178_RS22155	COG1862	Preprotein translocase
L6178_RS22185	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
L6178_RS22195	COG0697	spore germination
L6178_RS22200	COG0697	spore germination
L6178_RS22205	COG0640	Transcriptional regulator
L6178_RS22230	COG0157	Belongs to the NadC ModD family
L6178_RS22235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L6178_RS22240	COG1104	cysteine desulfurase activity
L6178_RS22245	COG1827	regulation of RNA biosynthetic process
L6178_RS22250	COG2258	MOSC domain
L6178_RS22255	COG0077	Prephenate dehydratase
L6178_RS22260	COG0577	efflux transmembrane transporter activity
L6178_RS22265	COG0577	efflux transmembrane transporter activity
L6178_RS22270	COG1136	(ABC) transporter
L6178_RS22280	COG0745	RESPONSE REGULATOR receiver
L6178_RS22285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L6178_RS22290	COG3290	protein histidine kinase activity
L6178_RS22300	COG2868	ribosomal protein
L6178_RS22310	COG1530	ribonuclease E activity
L6178_RS22315	COG1994	Peptidase M50
L6178_RS22320	COG0739	heme binding
L6178_RS22325	COG2894	cell division
L6178_RS22345	COG1077	Cell shape determining protein MreB Mrl
L6178_RS22365	COG0285	dihydrofolate synthase activity
L6178_RS22370	COG0525	valine-tRNA ligase activity
L6178_RS22380	COG1388	LysM domain
L6178_RS22390	COG0113	porphobilinogen synthase activity
L6178_RS22395	COG1587	Uroporphyrinogen-III synthase
L6178_RS22405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6178_RS22415	COG1846	Transcriptional regulator
L6178_RS22420	COG1764	response to oxidative stress
L6178_RS22435	COG1067	ATP-dependent peptidase activity
L6178_RS22435	COG0470	DNA polymerase III
L6178_RS22480	COG0622	Phosphoesterase
L6178_RS22495	COG5401	PFAM Sporulation and spore germination
L6178_RS22515	COG1309	transcriptional regulator
L6178_RS22530	COG2197	response regulator
L6178_RS22535	COG2233	PERMEase
L6178_RS22545	COG0402	S-adenosylhomocysteine deaminase activity
L6178_RS22550	COG0402	S-adenosylhomocysteine deaminase activity
L6178_RS22560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6178_RS22570	COG0444	Belongs to the ABC transporter superfamily
L6178_RS22575	COG4608	Belongs to the ABC transporter superfamily
L6178_RS22580	COG3275	phosphorelay sensor kinase activity
L6178_RS22585	COG3279	Response regulator of the LytR AlgR family
L6178_RS22600	COG1983	PspC domain protein
L6178_RS22605	COG1396	sequence-specific DNA binding
L6178_RS22610	COG0697	spore germination
L6178_RS22620	COG1959	2 iron, 2 sulfur cluster binding
L6178_RS22625	COG1668	transmembrane transport
L6178_RS22630	COG4152	abc transporter atp-binding protein
L6178_RS22635	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
L6178_RS22645	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6178_RS22650	COG1876	peptidase activity
L6178_RS22655	COG0824	Thioesterase
L6178_RS22660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L6178_RS22665	COG1053	succinate dehydrogenase
L6178_RS22670	COG2009	succinate dehydrogenase
L6178_RS22675	COG1719	4-vinyl reductase, 4VR
L6178_RS22685	COG3118	belongs to the thioredoxin family
L6178_RS22690	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L6178_RS22695	COG2086	electron transfer activity
L6178_RS22700	COG1024	Enoyl-CoA hydratase
L6178_RS22710	COG0318	PFAM AMP-dependent synthetase and ligase
L6178_RS22730	COG2318	DinB family
L6178_RS22760	COG1131	(ABC) transporter
L6178_RS22765	COG2205	protein histidine kinase activity
L6178_RS22770	COG0745	RESPONSE REGULATOR receiver
L6178_RS22780	COG4895	conserved protein (DUF2196)
L6178_RS22785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L6178_RS22800	COG4509	Sortase family
L6178_RS22805	COG1120	ATPase activity
L6178_RS22820	COG5386	Cell surface protein
L6178_RS22830	COG5386	Cell surface protein
L6178_RS22835	COG1114	Component of the transport system for branched-chain amino acids
L6178_RS22840	COG1187	pseudouridine synthase activity
L6178_RS22850	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L6178_RS22850	COG1796	DNA polymerase
L6178_RS22855	COG1286	toxin biosynthetic process
L6178_RS22900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6178_RS22910	COG1418	mRNA catabolic process
L6178_RS22935	COG2814	Major facilitator Superfamily
L6178_RS22940	COG1566	PFAM secretion protein HlyD family protein
L6178_RS22945	COG1309	transcriptional regulator
L6178_RS22950	COG1363	Peptidase, m42
L6178_RS22975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6178_RS22985	COG1484	DNA-dependent DNA replication
L6178_RS22990	COG3611	Membrane attachment protein
L6178_RS23000	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
L6178_RS23005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6178_RS23010	COG0237	dephospho-CoA kinase activity
L6178_RS23015	COG1971	Probably functions as a manganese efflux pump
L6178_RS23025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6178_RS23025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6178_RS23030	COG5002	protein histidine kinase activity
L6178_RS23035	COG0745	RESPONSE REGULATOR receiver
L6178_RS23055	COG0538	isocitrate dehydrogenase activity
L6178_RS23060	COG0372	Belongs to the citrate synthase family
L6178_RS23070	COG0628	permease
L6178_RS23075	COG3030	protein affecting phage T7 exclusion by the F plasmid
L6178_RS23100	COG1725	Transcriptional regulator
L6178_RS23105	COG0281	malic enzyme
L6178_RS23110	COG0587	DNA-directed DNA polymerase activity
L6178_RS23125	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L6178_RS23145	COG4109	DRTGG domain
L6178_RS23160	COG0006	proline dipeptidase activity
L6178_RS23200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_RS23205	COG0662	Cupin 2, conserved barrel domain protein
L6178_RS23215	COG1476	TRANSCRIPTIONal
L6178_RS23230	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_RS23235	COG0589	response to stress
L6178_RS23275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_RS23295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L6178_RS23300	COG0827	DNA restriction-modification system
L6178_RS23305	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L6178_RS23310	COG3874	Sporulation protein YtfJ
L6178_RS23325	COG1574	metal-dependent hydrolase with the TIM-barrel fold
L6178_RS23335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6178_RS23350	COG1104	cysteine desulfurase activity
L6178_RS23360	COG0583	DNA-binding transcription factor activity
L6178_RS23365	COG0697	spore germination
L6178_RS23375	COG1956	GAF domain-containing protein
L6178_RS23380	COG0626	cystathionine gamma-synthase activity
L6178_RS23410	COG1595	DNA-templated transcription, initiation
L6178_RS23420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6178_RS23425	COG0454	-acetyltransferase
L6178_RS23430	COG0517	IMP dehydrogenase activity
L6178_RS23435	COG0123	including yeast histone deacetylase and acetoin utilization protein
L6178_RS23445	COG0745	RESPONSE REGULATOR receiver
L6178_RS23455	COG0666	response to abiotic stimulus
L6178_RS23490	COG1609	Transcriptional regulator
L6178_RS23495	COG4851	CamS sex pheromone cAM373 precursor
L6178_RS23500	COG3118	belongs to the thioredoxin family
L6178_RS23510	COG2309	aminopeptidase activity
L6178_RS23530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_RS23545	COG1674	ftsk spoiiie
L6178_RS23555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6178_RS23560	COG4848	Belongs to the UPF0354 family
L6178_RS23565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6178_RS23570	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
L6178_RS23575	COG1363	Peptidase, m42
L6178_RS23585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_RS23600	COG0510	thiamine kinase activity
L6178_RS23605	COG1523	belongs to the glycosyl hydrolase 13 family
L6178_RS23620	COG1349	DNA-binding transcription factor activity
L6178_RS23625	COG1187	pseudouridine synthase activity
L6178_RS23630	COG2244	polysaccharide biosynthetic process
L6178_RS23635	COG2081	HI0933 family
L6178_RS23640	COG2814	Major facilitator Superfamily
L6178_RS23650	COG3832	glyoxalase III activity
L6178_RS23670	COG1329	Transcriptional regulator
L6178_RS23680	COG4975	Glucose uptake
L6178_RS23695	COG0314	molybdopterin synthase activity
L6178_RS23700	COG1763	Mo-molybdopterin cofactor biosynthetic process
L6178_RS23705	COG0303	'Molybdopterin
L6178_RS23715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6178_RS23740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6178_RS23750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L6178_RS23795	COG2814	Major facilitator Superfamily
L6178_RS23800	COG0475	glutathione-regulated potassium exporter activity
L6178_RS23805	COG0490	domain, Protein
L6178_RS23810	COG0582	viral genome integration into host DNA
L6178_RS23820	COG1136	(ABC) transporter
L6178_RS23840	COG1242	4 iron, 4 sulfur cluster binding
L6178_RS23845	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
L6178_RS23850	COG1131	(ABC) transporter
L6178_RS23860	COG1794	racemase activity, acting on amino acids and derivatives
L6178_RS23880	COG2267	carboxylic ester hydrolase activity
L6178_RS23885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L6178_RS23890	COG0671	phosphoesterase, PA-phosphatase related
L6178_RS23895	COG0438	transferase activity, transferring glycosyl groups
L6178_RS23905	COG0521	Mo-molybdopterin cofactor biosynthetic process
L6178_RS23960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L6178_RS23965	COG5002	protein histidine kinase activity
L6178_RS23970	COG4191	Histidine kinase
L6178_RS23975	COG2267	carboxylic ester hydrolase activity
L6178_RS23995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6178_RS24000	COG1116	anion transmembrane transporter activity
L6178_RS24005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6178_RS24030	COG0494	nUDIX hydrolase
L6178_RS24065	COG0288	reversible hydration of carbon dioxide
L6178_RS24070	COG1271	oxidase subunit
L6178_RS24075	COG1294	oxidase, subunit
L6178_RS24095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_RS24120	COG1842	Phage shock protein A
L6178_RS24150	COG5002	protein histidine kinase activity
L6178_RS24155	COG0745	RESPONSE REGULATOR receiver
L6178_RS24185	COG1597	lipid kinase activity
L6178_RS24220	COG0586	Pfam SNARE associated Golgi protein
L6178_RS24230	COG0577	efflux transmembrane transporter activity
L6178_RS24235	COG1136	(ABC) transporter
L6178_RS24240	COG2207	Transcriptional regulator
L6178_RS24240	COG3708	Transcriptional regulator
L6178_RS24245	COG0745	RESPONSE REGULATOR receiver
L6178_RS24250	COG2205	protein histidine kinase activity
L6178_RS24260	COG0577	efflux transmembrane transporter activity
L6178_RS24265	COG1136	(ABC) transporter
L6178_RS24285	COG2188	Transcriptional regulator
L6178_RS24305	COG3964	amidohydrolase
L6178_RS24335	COG4948	Mandelate Racemase Muconate Lactonizing
L6178_RS24345	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L6178_RS24350	COG0596	Alpha beta hydrolase
L6178_RS24355	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
L6178_RS24360	COG1169	isochorismate synthase
L6178_RS24365	COG1575	Belongs to the MenA family. Type 1 subfamily
L6178_RS24370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L6178_RS24390	COG0058	SHG alpha-glucan phosphorylase activity
L6178_RS24395	COG0297	glycogen (starch) synthase activity
L6178_RS24400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L6178_RS24515	COG0544	peptidyl-prolyl cis-trans isomerase activity
L6178_RS24550	COG1285	pathogenesis
L6178_RS24555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L6178_RS24565	COG0166	Belongs to the GPI family
L6178_RS24570	COG2155	Conserved Protein
L6178_RS24575	COG1098	S1 RNA binding domain
L6178_RS24580	COG0436	Aminotransferase
L6178_RS24585	COG1522	sequence-specific DNA binding
L6178_RS24590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6178_RS24595	COG2267	carboxylic ester hydrolase activity
L6178_RS24605	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L6178_RS24625	COG5018	Exonuclease
L6178_RS24630	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6178_RS24650	COG2050	protein possibly involved in aromatic compounds catabolism
L6178_RS24660	COG1268	BioY protein
L6178_RS24670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L6178_RS24675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L6178_RS24690	COG3584	3D domain protein
L6178_RS24705	COG1252	NADH dehydrogenase
L6178_RS24720	COG3708	Transcriptional regulator
L6178_RS24735	COG1683	Conserved Protein
L6178_RS24755	COG0316	Belongs to the HesB IscA family
L6178_RS24770	COG1252	NADH dehydrogenase
L6178_RS24785	COG0390	transport system, permease component
L6178_RS24790	COG2824	Alkylphosphonate utilization operon protein PhnA
L6178_RS24830	COG4837	Protein of unknown function (DUF1462)
L6178_RS24835	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L6178_RS24845	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6178_RS24850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L6178_RS24860	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6178_RS24865	COG0647	UMP catabolic process
L6178_RS24875	COG2445	Protein of unknown function DUF86
L6178_RS24880	COG1494	fructose-1,6-bisphosphatase
L6178_RS24895	COG4470	Protein conserved in bacteria
L6178_RS24905	COG0789	Transcriptional regulator
L6178_RS24910	COG4377	Putative membrane peptidase family (DUF2324)
L6178_RS24935	COG0739	heme binding
L6178_RS24945	COG3377	Domain of unknown function (DUF1805)
L6178_RS24950	COG0737	Belongs to the 5'-nucleotidase family
L6178_RS24955	COG1695	Transcriptional regulator
L6178_RS24965	COG0719	Fe-S assembly protein
L6178_RS24970	COG0822	iron-sulfur transferase activity
L6178_RS24975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L6178_RS24980	COG0719	Fe-S assembly protein
L6178_RS24985	COG0396	ATPase activity
L6178_RS24990	COG1464	Belongs to the NlpA lipoprotein family
L6178_RS24995	COG1464	Belongs to the NlpA lipoprotein family
L6178_RS25000	COG2011	ABC-type metal ion transport system permease component
L6178_RS25005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6178_RS25015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6178_RS25020	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L6178_RS25030	COG1393	Belongs to the ArsC family
L6178_RS25075	COG0039	L-malate dehydrogenase activity
L6178_RS25100	COG1309	transcriptional regulator
L6178_RS25105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_RS25110	COG1960	acyl-CoA dehydrogenase activity
L6178_RS25115	COG0183	Belongs to the thiolase family
L6178_RS25120	COG1024	Enoyl-CoA hydratase
L6178_RS25120	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6178_RS25130	COG1686	Belongs to the peptidase S11 family
L6178_RS25145	COG0011	TIGRFAM Protein of
L6178_RS25150	COG0840	transmembrane signaling receptor activity
L6178_RS25170	COG2814	Major facilitator Superfamily
L6178_RS25175	COG0531	amino acid
L6178_RS25185	COG0706	membrane insertase activity
L6178_RS25195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_RS25230	COG0586	Pfam SNARE associated Golgi protein
L6178_RS25240	COG1376	ErfK ybiS ycfS ynhG family protein
L6178_RS25250	COG5002	protein histidine kinase activity
L6178_RS25275	COG2151	metal-sulfur cluster biosynthetic enzyme
L6178_RS25280	COG3227	Zinc metalloprotease (Elastase)
L6178_RS25285	COG1741	Belongs to the pirin family
L6178_RS25300	COG0475	glutathione-regulated potassium exporter activity
L6178_RS25305	COG0490	domain, Protein
L6178_RS25310	COG1115	amino acid carrier protein
L6178_RS25315	COG0783	Belongs to the Dps family
L6178_RS25330	COG1611	Belongs to the LOG family
L6178_RS25350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6178_RS25355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6178_RS25360	COG1115	amino acid carrier protein
L6178_RS25365	COG1115	amino acid carrier protein
L6178_RS25370	COG2910	NAD(P)H-binding
L6178_RS25385	COG0656	L-ascorbic acid biosynthetic process
L6178_RS25390	COG2814	Major facilitator Superfamily
L6178_RS25395	COG1733	regulation of RNA biosynthetic process
L6178_RS25405	COG1252	NADH dehydrogenase
L6178_RS25410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L6178_RS25415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L6178_RS25425	COG3290	protein histidine kinase activity
L6178_RS25425	COG0840	transmembrane signaling receptor activity
L6178_RS25435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L6178_RS25440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L6178_RS25455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_RS25510	COG0557	exoribonuclease II activity
L6178_RS25515	COG1647	Serine aminopeptidase, S33
L6178_RS25520	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L6178_RS25525	COG1346	cytolysis
L6178_RS25620	COG4695	Portal protein
L6178_RS25645	COG4974	Belongs to the 'phage' integrase family
L6178_RS25655	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L6178_RS25660	COG0149	triose-phosphate isomerase activity
L6178_RS25670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6178_RS25685	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L6178_RS25710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6178_RS25725	COG2323	membrane
L6178_RS25730	COG0740	serine-type endopeptidase activity
L6178_RS25735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6178_RS25745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L6178_RS25755	COG1051	belongs to the nudix hydrolase family
L6178_RS25765	COG0492	ferredoxin-NADP+ reductase activity
L6178_RS25770	COG0457	Tetratricopeptide repeat
L6178_RS25775	COG0110	maltose O-acetyltransferase activity
L6178_RS25795	COG1950	PFAM Membrane protein of
L6178_RS25805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6178_RS25810	COG0556	nucleotide-excision repair
L6178_RS25830	COG0789	Transcriptional regulator
L6178_RS25855	COG2855	membrane
L6178_RS25860	COG0583	DNA-binding transcription factor activity
L6178_RS25870	COG0655	NAD(P)H dehydrogenase (quinone) activity
L6178_RS25875	COG0488	(ABC) transporter
L6178_RS25885	COG1132	(ABC) transporter
L6178_RS25890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6178_RS25895	COG0793	Belongs to the peptidase S41A family
L6178_RS25895	COG3409	Peptidoglycan-binding domain 1 protein
L6178_RS25900	COG2177	Part of the ABC transporter FtsEX involved in
L6178_RS25905	COG2884	Cell division ATP-binding protein ftsE
L6178_RS25920	COG0653	protein targeting
L6178_RS25925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L6178_RS25930	COG1278	Cold shock
L6178_RS25935	COG1040	competence protein
L6178_RS25940	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
L6178_RS25945	COG1388	LysM domain
L6178_RS25945	COG0791	NLP P60 protein
L6178_RS25950	COG1733	regulation of RNA biosynthetic process
L6178_RS25955	COG1307	EDD domain protein, DegV family
L6178_RS25960	COG1739	Uncharacterized protein family UPF0029
L6178_RS25965	COG1316	TRANSCRIPTIONal
L6178_RS25970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L6178_RS25975	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L6178_RS25980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L6178_RS25990	COG3933	PFAM sigma-54 factor interaction domain-containing protein
L6178_RS25990	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
L6178_RS26005	COG3394	polysaccharide catabolic process
L6178_RS26010	COG1486	melibiose metabolic process
L6178_RS26015	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6178_RS26020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6178_RS26030	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L6178_RS26035	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
L6178_RS26040	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6178_RS26050	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6178_RS26055	COG1301	dicarboxylic acid transport
L6178_RS26065	COG0346	lactoylglutathione lyase activity
L6178_RS26070	COG1511	domain protein
L6178_RS26075	COG0583	DNA-binding transcription factor activity
L6178_RS26080	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
L6178_RS26095	COG1271	oxidase subunit
L6178_RS26100	COG1294	oxidase, subunit
L6178_RS26105	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6178_RS26115	COG1620	l-lactate permease
L6178_RS26125	COG2389	metal-binding protein
L6178_RS26135	COG1368	sulfuric ester hydrolase activity
L6178_RS26150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6178_RS26165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6178_RS26170	COG3584	3D domain protein
L6178_RS26170	COG1388	LysM domain
L6178_RS26195	COG4715	Zinc finger, swim domain protein
L6178_RS26200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6178_RS26240	COG0577	efflux transmembrane transporter activity
L6178_RS26245	COG1136	(ABC) transporter
L6178_RS26280	COG5002	protein histidine kinase activity
L6178_RS26285	COG0745	RESPONSE REGULATOR receiver
L6178_RS26290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6178_RS26310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L6178_RS26315	COG1134	teichoic acid transport
L6178_RS26320	COG1682	transport, permease protein
L6178_RS26325	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L6178_RS26370	COG1609	Transcriptional regulator
L6178_RS26385	COG0739	heme binding
L6178_RS26405	COG2385	sporulation resulting in formation of a cellular spore
L6178_RS26420	COG4836	Membrane
L6178_RS26425	COG1007	ATP synthesis coupled electron transport
L6178_RS26430	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6178_RS26435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L6178_RS26445	COG0839	Belongs to the complex I subunit 6 family
L6178_RS26460	COG0649	NAD binding
L6178_RS26465	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6178_RS26480	COG5001	Diguanylate cyclase
L6178_RS26480	COG3300	MHYT domain
L6178_RS26530	COG0356	it plays a direct role in the translocation of protons across the membrane
L6178_RS26565	COG0698	ribose 5-phosphate isomerase
L6178_RS26575	COG2190	(PTS) system
L6178_RS26580	COG2259	Doxx family
L6178_RS26585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L6178_RS26600	COG0009	L-threonylcarbamoyladenylate synthase
L6178_RS26615	COG2890	protein-(glutamine-N5) methyltransferase activity
L6178_RS26635	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L6178_RS26640	COG1494	fructose-1,6-bisphosphatase
L6178_RS26660	COG4821	SIS domain
L6178_RS26670	COG3343	RNA polymerase activity
L6178_RS26680	COG1960	acyl-CoA dehydrogenase activity
L6178_RS26685	COG1960	acyl-CoA dehydrogenase activity
L6178_RS26690	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6178_RS26695	COG0183	Belongs to the thiolase family
L6178_RS26700	COG0247	lactate metabolic process
L6178_RS26700	COG2181	nitrate reductase activity
L6178_RS26705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6178_RS26715	COG3300	MHYT domain
L6178_RS26715	COG5001	Diguanylate cyclase
L6178_RS26735	COG2197	response regulator
L6178_RS26740	COG4585	Histidine kinase
L6178_RS26745	COG0842	Transport permease protein
L6178_RS26750	COG1131	(ABC) transporter
L6178_RS26755	COG0024	Methionine aminopeptidase
L6178_RS26765	COG2234	aminopeptidase activity
L6178_RS26785	COG1595	DNA-templated transcription, initiation
L6178_RS26790	COG0018	arginyl-trna synthetase
L6178_RS26795	COG4506	Protein conserved in bacteria
L6178_RS26800	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6178_RS26815	COG0010	Belongs to the arginase family
L6178_RS26825	COG2814	Major facilitator Superfamily
L6178_RS26830	COG0789	Transcriptional regulator
L6178_RS26835	COG0584	glycerophosphoryl diester phosphodiesterase
L6178_RS26840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6178_RS26850	COG1994	Peptidase M50
L6178_RS26860	COG1078	dGTPase activity
L6178_RS26865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6178_RS26870	COG1120	ATPase activity
L6178_RS26875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_RS26900	COG0095	Lipoate-protein ligase
L6178_RS26905	COG0280	phosphate acetyltransferase
L6178_RS26920	COG3773	Cell wall hydrolase
L6178_RS26930	COG2363	Small membrane protein
L6178_RS26945	COG2233	PERMEase
L6178_RS26950	COG0561	phosphatase activity
L6178_RS26955	COG2814	Major facilitator Superfamily
L6178_RS26965	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6178_RS26970	COG1131	(ABC) transporter
L6178_RS26975	COG2755	lipolytic protein G-D-S-L family
L6178_RS26980	COG1609	Transcriptional regulator
L6178_RS26990	COG0460	homoserine dehydrogenase
L6178_RS27000	COG2873	o-acetylhomoserine
L6178_RS27010	COG1011	Hydrolase
L6178_RS27015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6178_RS27025	COG2197	response regulator
L6178_RS27035	COG0351	phosphomethylpyrimidine kinase
L6178_RS27040	COG3706	GGDEF domain
L6178_RS27045	COG2879	small protein
L6178_RS27050	COG1966	Carbon starvation protein
L6178_RS27055	COG3279	Response regulator of the LytR AlgR family
L6178_RS27060	COG0477	Major facilitator Superfamily
L6178_RS27085	COG0840	transmembrane signaling receptor activity
L6178_RS27095	COG1607	acyl-coa hydrolase
L6178_RS27110	COG0488	(ABC) transporter
L6178_RS27130	COG0463	Glycosyl transferase, family 2
L6178_RS27135	COG1309	transcriptional regulator
L6178_RS27140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6178_RS27145	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6178_RS27145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6178_RS27150	COG0628	permease
L6178_RS27165	COG3279	Response regulator of the LytR AlgR family
L6178_RS27170	COG3275	phosphorelay sensor kinase activity
L6178_RS27175	COG2814	Major facilitator Superfamily
L6178_RS27180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6178_RS27185	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
L6178_RS27190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6178_RS27210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6178_RS27215	COG1272	protein, Hemolysin III
L6178_RS27235	COG0516	GMP reductase activity
L6178_RS27240	COG1164	Oligoendopeptidase f
L6178_RS27260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6178_RS27265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L6178_RS27270	COG4853	Protein conserved in bacteria
L6178_RS27275	COG4863	YycH protein
L6178_RS27280	COG5002	protein histidine kinase activity
L6178_RS27285	COG0745	RESPONSE REGULATOR receiver
L6178_RS27315	COG0305	Participates in initiation and elongation during chromosome replication
L6178_RS27325	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
L6178_RS27330	COG4241	membrane
L6178_RS27340	COG0629	single-stranded DNA binding
L6178_RS27350	COG0012	GTP binding
L6178_RS27355	COG4481	Protein conserved in bacteria
L6178_RS27360	COG0668	transmembrane transport
L6178_RS27370	COG1475	DNA binding
L6178_RS27375	COG1192	Involved in chromosome partitioning
L6178_RS27400	COG1847	R3H domain protein
L6178_RS27405	COG0706	membrane insertase activity
L6178_RS27415	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L6178_RS27450	COG0791	NLP P60 protein
L6178_RS27450	COG0741	lytic transglycosylase activity
L6178_RS27605	COG1192	Involved in chromosome partitioning
L6178_RS27650	COG1683	Conserved Protein
L6178_RS27655	COG1309	transcriptional regulator
L6178_RS27730	COG0681	Belongs to the peptidase S26 family
L6178_RS27760	COG1280	lysine exporter protein (LysE YggA)
L6178_RS27805	COG4166	transmembrane transport
L6178_RS27815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII