locus-tag class description FOC06_RS00010 ENOG4105CH6 catalase FOC06_RS00020 ENOG4105D5Q Arginine ornithine antiporter FOC06_RS00025 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC06_RS00035 ENOG4105C26 Dehydrogenase FOC06_RS00040 ENOG4105BZ1 (ABC) transporter FOC06_RS00055 ENOG4105DRP amino acid AbC transporter FOC06_RS00060 ENOG4105CDA abc transporter atp-binding protein FOC06_RS00075 ENOG410839P FOC06_RS00110 ENOG4107FQX Alpha-acetolactate decarboxylase FOC06_RS00140 ENOG4105D4P Coproporphyrinogen iii oxidase FOC06_RS00155 ENOG4105CHH sulfate transporter FOC06_RS00195 ENOG4106AKK s-layer domain-containing protein FOC06_RS00205 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC06_RS00210 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC06_RS00225 ENOG4105CGU Enoyl-CoA hydratase FOC06_RS00245 ENOG4105DER m42 family FOC06_RS00265 ENOG4105CTU Proline racemase FOC06_RS00305 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC06_RS00315 ENOG4108JQ7 (ABC) transporter FOC06_RS00320 ENOG4105PKS Excinuclease abc c subunit domain protein FOC06_RS00350 ENOG4105CSH Transporter FOC06_RS00360 ENOG4108MRH transcriptional regulatory protein FOC06_RS00410 ENOG4105CDU Replicative dna helicase FOC06_RS00440 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC06_RS00485 ENOG4107P5I polyketide synthase FOC06_RS00490 ENOG4108IG5 Transcriptional regulator FOC06_RS00510 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC06_RS00530 ENOG4105CMT Dihydroxyacetone kinase FOC06_RS00540 ENOG4105CMT Dihydroxyacetone kinase FOC06_RS00545 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC06_RS00550 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC06_RS00580 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC06_RS00645 ENOG4105WN5 stage II sporulation protein FOC06_RS00655 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC06_RS00665 ENOG4108MJI response regulator FOC06_RS00670 ENOG4105BZU Histidine kinase FOC06_RS00675 ENOG4105BZU Histidine kinase FOC06_RS00695 ENOG4105K8R UPF0145 protein FOC06_RS00725 ENOG4107VRP DNA repair exonuclease FOC06_RS00735 ENOG4105D7V transposase FOC06_RS00750 ENOG4108IND Tetr family transcriptional regulator FOC06_RS00755 ENOG4105EQ0 Major Facilitator superfamily FOC06_RS00775 ENOG4108MUZ hydrolase FOC06_RS00795 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC06_RS00810 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC06_RS00820 ENOG4105EMN RNA polymerase sigma factor FOC06_RS00845 ENOG4105C57 major facilitator superfamily FOC06_RS00850 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC06_RS00860 ENOG4105EEM helicase FOC06_RS00890 ENOG4105K59 histidine triad (HIT) protein FOC06_RS00920 ENOG410905X membrane-flanked domain protein FOC06_RS00965 ENOG410905X membrane-flanked domain protein FOC06_RS00970 ENOG4105CKV Membrane FOC06_RS00975 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC06_RS00980 ENOG4105BZ4 penicillin-binding protein FOC06_RS00985 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOC06_RS00995 ENOG4105C1Q protoporphyrinogen oxidase FOC06_RS01020 ENOG4105NA0 Transcriptional regulator FOC06_RS01035 ENOG4105ECB domain protein FOC06_RS01065 ENOG4106AXD FOC06_RS01070 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC06_RS01075 ENOG4105DF9 Lipoate-protein, ligase FOC06_RS01085 ENOG4105CEY Amp-dependent synthetase and ligase FOC06_RS01115 ENOG4105CNA YD repeat protein FOC06_RS01150 ENOG4107TVP HD domain protein FOC06_RS01160 ENOG4108AEY RNA polymerase sigma factor FOC06_RS01165 ENOG41086D8 Transcriptional regulator FOC06_RS01180 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC06_RS01205 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC06_RS01210 ENOG4105C8Q Methyl-accepting chemotaxis FOC06_RS01230 ENOG4105ZU5 s-layer protein FOC06_RS01235 ENOG4107QP3 malate synthase g FOC06_RS01250 ENOG4105VEQ Cold shock protein FOC06_RS01265 ENOG4105XVF Competence transcription factor FOC06_RS01280 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination FOC06_RS01285 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC06_RS01330 ENOG4105ERH Fumarylacetoacetate hydrolase FOC06_RS01355 ENOG4105CAQ asparagine synthetase FOC06_RS01360 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC06_RS01365 ENOG4105CH6 catalase FOC06_RS01390 ENOG4105QNR S1 RNA binding domain protein FOC06_RS01400 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC06_RS01410 ENOG4107AYK membrAne FOC06_RS01415 ENOG41073B9 FOC06_RS01425 ENOG4108KP7 hydrolase FOC06_RS01435 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC06_RS01460 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC06_RS01465 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC06_RS01480 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC06_RS01495 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC06_RS01500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC06_RS01510 ENOG4108JQ7 (ABC) transporter FOC06_RS01515 ENOG4105UQX Mate efflux family protein FOC06_RS01535 ENOG4108ZCF integral membrane protein FOC06_RS01545 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC06_RS01555 ENOG4105DPN Oligoendopeptidase f FOC06_RS01565 ENOG4108Z18 K06886 hemoglobin FOC06_RS01570 ENOG4105MIX Adenylate cyclase FOC06_RS01585 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC06_RS01590 ENOG4105EMS pseudouridine synthase FOC06_RS01610 ENOG4105K64 Glycosyl transferase, family 2 FOC06_RS01630 ENOG4107TVC Glycosyl transferase, family 2 FOC06_RS01650 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC06_RS01655 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC06_RS01665 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC06_RS01715 ENOG4108WVJ 2'-5' rna ligase FOC06_RS01740 ENOG4105CK7 Sodium proline symporter FOC06_RS01750 ENOG4105DDQ anthranilate synthase FOC06_RS01845 ENOG4105C7S Dehydrogenase FOC06_RS01855 ENOG4105VZ8 Transcriptional regulator FOC06_RS01915 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC06_RS01925 ENOG4105DZ1 carboxypeptidase FOC06_RS01930 ENOG4105VFR signal peptidase FOC06_RS01965 ENOG4105C26 Dehydrogenase FOC06_RS01970 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC06_RS01975 ENOG4105F38 ABC transporter, permease FOC06_RS01980 ENOG4105D38 putrescine abc transporter FOC06_RS01985 ENOG4107RUE extracellular solute-binding protein family 1 FOC06_RS01995 ENOG4105EYF MMPL domain protein FOC06_RS02005 ENOG4108YBP pseudouridine synthase FOC06_RS02015 ENOG4105K4I Scp-like extracellular FOC06_RS02020 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC06_RS02025 ENOG4105CQB FAD linked oxidase domain protein FOC06_RS02040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_RS02045 ENOG4105BZU Histidine kinase FOC06_RS02050 ENOG4105JXH GntR family transcriptional regulator FOC06_RS02070 ENOG4106A3R peptidase FOC06_RS02080 ENOG4108QTI )-transporter FOC06_RS02085 ENOG4107TS3 membrane protein, TerC FOC06_RS02090 ENOG4105CZN Potassium uptake protein FOC06_RS02095 ENOG410681C small acid-soluble spore protein FOC06_RS02100 ENOG4108Z7G MaoC domain protein dehydratase FOC06_RS02120 ENOG4105CHR reductase FOC06_RS02130 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC06_RS02145 ENOG4105C4Y ABC transporter FOC06_RS02160 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FOC06_RS02175 ENOG4105E98 transcriptional regulator DeoR family FOC06_RS02195 ENOG4105PXI polysaccharide deacetylase FOC06_RS02205 ENOG4105BZU Histidine kinase FOC06_RS02210 ENOG41090MY MarR family Transcriptional regulator FOC06_RS02220 ENOG4106DF1 FOC06_RS02225 ENOG4105BZU Histidine kinase FOC06_RS02235 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC06_RS02240 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC06_RS02275 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC06_RS02295 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC06_RS02300 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC06_RS02305 ENOG4105CZV ABC transporter FOC06_RS02315 ENOG4105CJ1 ABC, transporter FOC06_RS02355 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC06_RS02360 ENOG4105EA8 2-Nitropropane dioxygenase FOC06_RS02365 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC06_RS02375 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC06_RS02395 ENOG4105NQC Flavodoxin FOC06_RS02420 ENOG4107QMU Mate efflux family protein FOC06_RS02425 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC06_RS02455 ENOG4105CZN Potassium uptake protein FOC06_RS02460 ENOG41063Y9 FOC06_RS02465 ENOG4105KBJ sporulation protein ytfj FOC06_RS02490 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC06_RS02495 ENOG4105C7K acetolactate synthase FOC06_RS02500 ENOG4108ZP8 Acetolactate synthase small subunit FOC06_RS02505 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC06_RS02515 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOC06_RS02540 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC06_RS02575 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC06_RS02590 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC06_RS02595 ENOG4105E0M Sulfatase FOC06_RS02605 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC06_RS02625 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC06_RS02630 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC06_RS02640 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC06_RS02645 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC06_RS02650 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC06_RS02655 ENOG4105C8J )-transporter FOC06_RS02675 ENOG4105DFD Na H antiporter FOC06_RS02695 ENOG4105ENE Histidine kinase FOC06_RS02700 ENOG4105WH1 Two component transcriptional regulator luxr family FOC06_RS02720 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC06_RS02745 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC06_RS02765 ENOG4105CJ3 phosphate transporter FOC06_RS02770 ENOG4107GRR phosphate transport regulator FOC06_RS02775 ENOG4105BZ4 penicillin-binding protein FOC06_RS02795 ENOG4105I3N Conserved Protein FOC06_RS02810 ENOG4105BZU Histidine kinase FOC06_RS02845 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC06_RS02850 ENOG4105DZ1 carboxypeptidase FOC06_RS02855 ENOG4108JIC nucleoside recognition domain protein FOC06_RS02865 ENOG4105FE9 pseudouridine synthase FOC06_RS02875 ENOG4107TWT Cytochrome c biogenesis protein FOC06_RS02880 ENOG4105CRE cytochrome C FOC06_RS02885 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_RS02890 ENOG4105BZU Histidine kinase FOC06_RS02895 ENOG4108WBT adenosyltransferase FOC06_RS02910 ENOG4108SAX Membrane FOC06_RS02920 ENOG4105T7X FOC06_RS02925 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC06_RS02930 ENOG4105I7S Abortive infection protein FOC06_RS02945 ENOG4107X2D transcriptional regulator, merr family FOC06_RS02950 ENOG4108S6Z Negative regulator of genetic competence FOC06_RS02975 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC06_RS02980 ENOG4105HDK L-asparaginase FOC06_RS03015 ENOG4105S2F FOC06_RS03020 ENOG41065D1 FOC06_RS03050 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC06_RS03065 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC06_RS03075 ENOG4105EAH synthase FOC06_RS03095 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC06_RS03100 ENOG41068YB TPR repeat-containing protein FOC06_RS03115 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC06_RS03120 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC06_RS03125 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC06_RS03155 ENOG4108JYZ YitT family FOC06_RS03160 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC06_RS03175 ENOG4105FJR Lmbe family FOC06_RS03180 ENOG4105CPK Glycosyl transferase (Group 1 FOC06_RS03215 ENOG4105DVT helicase FOC06_RS03220 ENOG4105YAC FOC06_RS03240 ENOG4105CSM endonuclease III FOC06_RS03250 ENOG4105BZ4 penicillin-binding protein FOC06_RS03305 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC06_RS03315 ENOG4105DVT helicase FOC06_RS03320 ENOG4105CTD carboxy-peptidase FOC06_RS03335 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC06_RS03350 ENOG4105C2W permease FOC06_RS03355 ENOG4105DHF Membrane FOC06_RS03360 ENOG410890F Dynamin family FOC06_RS03370 ENOG4108W0I acetyltransferase FOC06_RS03380 ENOG4105KHC sulfurtransferase FOC06_RS03480 ENOG4108SZE gCN5-related N-acetyltransferase FOC06_RS03500 ENOG41081VK Ribonuclease FOC06_RS03565 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC06_RS03575 ENOG4107RWR Sodium hydrogen exchanger FOC06_RS03585 ENOG4108Z5V transcriptional regulator, merr family FOC06_RS03595 ENOG4105H67 Protein of unknown function (DUF421) FOC06_RS03600 ENOG41080C8 DUF218 domain FOC06_RS03655 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC06_RS03665 ENOG4107R0U MotA TolQ exbB proton channel FOC06_RS03670 ENOG4105ER2 Ompa motb domain protein FOC06_RS03675 ENOG4107YTP response regulator receiver protein FOC06_RS03685 ENOG4105DD5 Flagellar motor switch protein FOC06_RS03700 ENOG4105BZU Histidine kinase FOC06_RS03720 ENOG4105E1Q flagellar hook-associated protein FOC06_RS03745 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC06_RS03750 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC06_RS03755 ENOG41075Z6 flagellar hook-basal body complex protein fliE FOC06_RS03765 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC06_RS03800 ENOG4105BZE flagellar hook protein, FlgE FOC06_RS03825 ENOG4105K64 Glycosyl transferase, family 2 FOC06_RS03860 ENOG4105I03 Flagellin FOC06_RS03865 ENOG4105E4C Lytic transglycosylase catalytic FOC06_RS03880 ENOG4105DD5 Flagellar motor switch protein FOC06_RS03890 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC06_RS03895 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC06_RS03905 ENOG4105D00 flagellar biosynthetic protein flhB FOC06_RS03910 ENOG4105D7B Flagellar biosynthesis protein flha FOC06_RS03920 ENOG4105KTQ flagellar basal-body rod protein FOC06_RS03925 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC06_RS03950 ENOG4108RZE Tetr family transcriptional regulator FOC06_RS03970 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC06_RS03995 ENOG4105DUM transcriptional regulator, lysR family FOC06_RS04000 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC06_RS04005 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC06_RS04010 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC06_RS04015 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC06_RS04055 ENOG4105CVJ phosphoglycerate mutase FOC06_RS04085 ENOG4105CAQ asparagine synthetase FOC06_RS04105 ENOG4105PGM cation diffusion facilitator family transporter FOC06_RS04115 ENOG4105DRR Transcriptional regulator, GntR family FOC06_RS04120 ENOG4108UZ3 Transporter FOC06_RS04125 ENOG4105CKI cobalamin synthesis protein FOC06_RS04130 ENOG4108PJD permease FOC06_RS04145 ENOG4105DFD Na H antiporter FOC06_RS04150 ENOG4105C9Q fumarate hydratase class II FOC06_RS04175 ENOG4105EC3 peptidase S51, dipeptidase E FOC06_RS04195 ENOG4107QIV Cytochrome c biogenesis protein FOC06_RS04225 ENOG4106BRA Membrane FOC06_RS04260 ENOG4105CJ1 ABC, transporter FOC06_RS04280 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC06_RS04290 ENOG4108IJ0 Aspartate ammonia-lyase FOC06_RS04295 ENOG4105C6K Malic enzyme FOC06_RS04355 ENOG4105FVX FOC06_RS04395 ENOG4105CSR polyphosphate kinase 2 FOC06_RS04425 ENOG4105EU0 Major facilitator Superfamily FOC06_RS04430 ENOG4105C6T cysteine synthase FOC06_RS04450 ENOG4105C8J )-transporter FOC06_RS04460 ENOG4105X5K response regulator receiver protein FOC06_RS04465 ENOG4105H67 Protein of unknown function (DUF421) FOC06_RS04480 ENOG4106KE4 Dehydrogenase FOC06_RS04495 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC06_RS04500 ENOG4105CHR reductase FOC06_RS04505 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC06_RS04510 ENOG4105C7K acetolactate synthase FOC06_RS04515 ENOG4108ZP8 Acetolactate synthase small subunit FOC06_RS04520 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC06_RS04530 ENOG4105C7B Threonine dehydratase FOC06_RS04555 ENOG4105C6X Major Facilitator FOC06_RS04560 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC06_RS04570 ENOG4105DY9 regulatoR FOC06_RS04575 ENOG4105CYC Transferase FOC06_RS04595 ENOG4105F6J Alpha beta hydrolase fold FOC06_RS04630 ENOG41068WN FOC06_RS04650 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC06_RS04655 ENOG4105C72 UPF0176 protein FOC06_RS04665 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC06_RS04695 ENOG4107RHR regulatoR FOC06_RS04705 ENOG4105D9N nucleoside FOC06_RS04710 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC06_RS04745 ENOG4107RAQ aminopeptidase FOC06_RS04750 ENOG4107STQ Multicopper oxidase FOC06_RS04795 ENOG4108T5E Copper resistance protein FOC06_RS04800 ENOG4105KTB nuclear export factor GLE1 FOC06_RS04810 ENOG4107RT3 EamA-like transporter family FOC06_RS04815 ENOG4105GZI Transcriptional regulator FOC06_RS04820 ENOG4108Z40 Transcriptional regulator FOC06_RS04825 ENOG4107ZXU DSBA oxidoreductase FOC06_RS04830 ENOG4108TVJ Nitroreductase FOC06_RS04835 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC06_RS04840 ENOG4106F5Q Membrane FOC06_RS04845 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC06_RS04855 ENOG4105CKI cobalamin synthesis protein FOC06_RS04875 ENOG4108Z7G MaoC domain protein dehydratase FOC06_RS04880 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC06_RS04890 ENOG4105C0Z ABC transporter FOC06_RS04895 ENOG4108IV0 ABC, transporter FOC06_RS04900 ENOG4105C32 Amino acid ABC transporter (Permease) FOC06_RS04910 ENOG4105SKE transcriptional Regulator LysR family FOC06_RS04930 ENOG4105YGB Transcriptional regulator FOC06_RS04940 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC06_RS04945 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC06_RS04950 ENOG4108JJ9 ABC, transporter FOC06_RS04955 ENOG4108JJ8 (ABC) transporter FOC06_RS05005 ENOG4105EFI regulatoR FOC06_RS05010 ENOG4105BZU Histidine kinase FOC06_RS05030 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC06_RS05035 ENOG4108ZJ4 polysaccharide deacetylase FOC06_RS05055 ENOG4105D6E homoserine dehydrogenase FOC06_RS05080 ENOG4108KGH TRANSCRIPTIONal FOC06_RS05090 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC06_RS05095 ENOG4105BZU Histidine kinase FOC06_RS05100 ENOG4107VMI polysaccharide deacetylase FOC06_RS05110 ENOG4105KT7 mgtC SapB transporter FOC06_RS05115 ENOG4105VRR gCN5-related N-acetyltransferase FOC06_RS05125 ENOG4105DUU IucA IucC family protein FOC06_RS05130 ENOG4105CEY Amp-dependent synthetase and ligase FOC06_RS05145 ENOG4108WBH protein TIM barrel FOC06_RS05150 ENOG4105YWU small acid-soluble spore protein FOC06_RS05160 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC06_RS05210 ENOG4105KRN Transcriptional regulator, abrb family FOC06_RS05220 ENOG4105YVS arsR family transcriptional regulator FOC06_RS05225 ENOG4107SET aldo keto reductase FOC06_RS05230 ENOG4107XZQ multidrug resistance protein FOC06_RS05255 ENOG4105C8Q Methyl-accepting chemotaxis FOC06_RS05270 ENOG4108K88 Membrane FOC06_RS05275 ENOG4108WPJ Ferritin-like domain FOC06_RS05290 ENOG4105DEN Luciferase family FOC06_RS05310 ENOG4107QM2 Aldo Keto reductase FOC06_RS05315 ENOG4105CKI cobalamin synthesis protein FOC06_RS05370 ENOG4105DSE periplasmic solute binding protein FOC06_RS05375 ENOG4105K4T epimerase FOC06_RS05385 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC06_RS05410 ENOG4105CVJ phosphoglycerate mutase FOC06_RS05430 ENOG4107T5V SNARE associated Golgi FOC06_RS05445 ENOG4108PJD permease FOC06_RS05455 ENOG4108S4H thioesterase Superfamily protein FOC06_RS05465 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC06_RS05485 ENOG4105SXS Protein of unknown function (DUF456) FOC06_RS05490 ENOG4105C37 (CBS) domain FOC06_RS05510 ENOG4108Z7R Chaperone CsaA FOC06_RS05530 ENOG4108ZRV stage ii sporulation protein p FOC06_RS05540 ENOG4108VXD carboxy-peptidase FOC06_RS05550 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC06_RS05575 ENOG4108X4Q Hydrolase FOC06_RS05585 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC06_RS05590 ENOG4107RBS Methyltransferase FOC06_RS05605 ENOG41087PP glycosyltransferase MGT family FOC06_RS05610 ENOG4108JYZ YitT family FOC06_RS05615 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC06_RS05640 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC06_RS05690 ENOG4105KBJ sporulation protein ytfj FOC06_RS05715 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC06_RS05740 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC06_RS05750 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC06_RS05755 ENOG4105EMN RNA polymerase sigma factor FOC06_RS05780 ENOG4108V06 Glutathione peroxidase FOC06_RS05795 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC06_RS05815 ENOG4108IUE nitrate reductase beta subunit FOC06_RS05820 ENOG4105R3A Nitrate reductase FOC06_RS05845 ENOG4107V6Q Cyclic nucleotide-binding domain FOC06_RS05850 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC06_RS05855 ENOG4105D06 uba thif-type nad fad binding protein FOC06_RS05860 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC06_RS05865 ENOG4108ZAF Molybdopterin FOC06_RS05890 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC06_RS05895 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC06_RS05900 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC06_RS05905 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC06_RS05910 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC06_RS05915 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC06_RS05950 ENOG4105MCT stage V sporulation protein S FOC06_RS05965 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC06_RS05985 ENOG4105C5H ABC transporter FOC06_RS06000 ENOG4108UUM single-stranded DNA-binding protein FOC06_RS06030 ENOG4107YX5 Pfam:DUF548 FOC06_RS06035 ENOG4105C75 arginyL-tRNA synthetase FOC06_RS06060 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC06_RS06080 ENOG4105C5S asparaginyl-tRNA synthetase FOC06_RS06100 ENOG4105EC2 ftsk spoIIIe FOC06_RS06170 ENOG4105BZW Glycerate kinase FOC06_RS06175 ENOG4107QPK )-transporter FOC06_RS06180 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_RS06185 ENOG41062D9 Histidine kinase FOC06_RS06200 ENOG4105C8J )-transporter FOC06_RS06220 ENOG4107XGZ Hydrolase FOC06_RS06225 ENOG4105CY2 Citrate transporter FOC06_RS06230 ENOG4105C0A alcohol dehydrogenase FOC06_RS06245 ENOG4105KD7 acetyltransferase FOC06_RS06275 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC06_RS06295 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC06_RS06310 ENOG4107RVG penicillin-binding protein FOC06_RS06315 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC06_RS06320 ENOG4105E9Q Acyl-transferase FOC06_RS06325 ENOG4108UT2 hemolysin iii FOC06_RS06335 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC06_RS06345 ENOG4108RCR degv family FOC06_RS06350 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC06_RS06355 ENOG4108KF3 Electron transport protein SCO1 SenC FOC06_RS06360 ENOG4107Y70 Heat shock protein FOC06_RS06365 ENOG4105CAQ asparagine synthetase FOC06_RS06380 ENOG4108MES Periplasmic binding protein FOC06_RS06385 ENOG4105F0I Aminotransferase FOC06_RS06420 ENOG4105D8X mechanosensitive ion channel FOC06_RS06425 ENOG4105BZU Histidine kinase FOC06_RS06430 ENOG4105WH1 Two component transcriptional regulator luxr family FOC06_RS06465 ENOG4105CMG Carbohydrate kinase FOC06_RS06470 ENOG4105CMG Carbohydrate kinase FOC06_RS06500 ENOG4108IJ8 ABC transporter FOC06_RS06505 ENOG4105E90 ABC transporter FOC06_RS06540 ENOG4105C37 (CBS) domain FOC06_RS06565 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC06_RS06580 ENOG4107S4Y M20 DapE family protein YgeY FOC06_RS06585 ENOG4108TSC N-acetyltransferase FOC06_RS06590 ENOG4108JUB Transcriptional regulator FOC06_RS06595 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC06_RS06635 ENOG4108N23 SpoOM-related protein FOC06_RS06640 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC06_RS06650 ENOG4105SZ6 Thioredoxin FOC06_RS06665 ENOG4108IBT Inherit from COG: transposase FOC06_RS06770 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC06_RS06810 ENOG4105BZ4 penicillin-binding protein FOC06_RS06815 ENOG4105CZM Major Facilitator FOC06_RS06820 ENOG4105W8X HesB YadR YfhF-family protein FOC06_RS06830 ENOG4105DXD 2-methylcitrate dehydratase FOC06_RS06835 ENOG4105CR4 methylisocitrate lyase FOC06_RS06840 ENOG4105C1G acyl-Coa dehydrogenase FOC06_RS06845 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC06_RS06855 ENOG4105N14 lysine exporter protein LysE YggA FOC06_RS06860 ENOG4105E39 Enoyl-CoA hydratase FOC06_RS06875 ENOG4107RFY SbcCD D subunit FOC06_RS06880 ENOG4105EYH Exonuclease FOC06_RS06900 ENOG4105FCD Major Facilitator FOC06_RS06905 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC06_RS06910 ENOG4105E4F Isochorismate synthase FOC06_RS06915 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC06_RS06920 ENOG4105WQI isochorismatase FOC06_RS06925 ENOG4105CEY Amp-dependent synthetase and ligase FOC06_RS06930 ENOG4105WQT MbtH domain protein FOC06_RS06935 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC06_RS06950 ENOG4105K70 DNA-binding protein FOC06_RS06970 ENOG4105BZG amino acid carrier protein FOC06_RS06990 ENOG4105FE9 pseudouridine synthase FOC06_RS06995 ENOG4105C22 threonyL-tRNA synthetase FOC06_RS07010 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC06_RS07035 ENOG4108D32 Methyltransferase FOC06_RS07065 ENOG41081I9 integral membrane protein FOC06_RS07080 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC06_RS07090 ENOG4105EYF MMPL domain protein FOC06_RS07115 ENOG4105WCN acetyltransferase FOC06_RS07145 ENOG4105C1Q protoporphyrinogen oxidase FOC06_RS07155 ENOG41068WN FOC06_RS07165 ENOG4105VEQ Cold shock protein FOC06_RS07185 ENOG410667J hydrolase FOC06_RS07220 ENOG4107V2S Transcriptional regulator FOC06_RS07225 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC06_RS07240 ENOG4105DND Transcriptional regulator FOC06_RS07245 ENOG4108RPX mosc domain containing protein FOC06_RS07260 ENOG4105BZ1 (ABC) transporter FOC06_RS07265 ENOG4105BZ1 (ABC) transporter FOC06_RS07285 ENOG4108JCI Transcriptional regulator FOC06_RS07315 ENOG4108KPJ rna polymerase sigma factor FOC06_RS07365 ENOG4105RD7 BadF BadG BcrA BcrD FOC06_RS07375 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC06_RS07395 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC06_RS07410 ENOG4105C1J atp-dependent rna helicase FOC06_RS07425 ENOG4108RZE Tetr family transcriptional regulator FOC06_RS07445 ENOG41088CC tellurite resistance protein tehB FOC06_RS07455 ENOG4108I0C methyltransferase FOC06_RS07460 ENOG4107RA9 decarboxylase FOC06_RS07465 ENOG41090HR transcriptional regulator FOC06_RS07495 ENOG4105CIN aminoacyl-histidine dipeptidase FOC06_RS07520 ENOG4107RF6 penicillin-binding protein FOC06_RS07535 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC06_RS07540 ENOG4105ETE Transcriptional regulator (LacI family FOC06_RS07545 ENOG4105IE8 Alpha-ketoglutarate permease FOC06_RS07550 ENOG4105CK5 oxidoreductase FOC06_RS07575 ENOG4105D2N Aldolase FOC06_RS07580 ENOG4105DH8 myo-inositol catabolism FOC06_RS07610 ENOG4105VZ8 Transcriptional regulator FOC06_RS07625 ENOG4108VXD carboxy-peptidase FOC06_RS07645 ENOG41067SE Tetr family transcriptional regulator FOC06_RS07650 ENOG4105C5H ABC transporter FOC06_RS07660 ENOG4105BZU Histidine kinase FOC06_RS07675 ENOG4106ANW SMI1_KNR4 FOC06_RS07680 ENOG4105CEP NADH dehydrogenase FOC06_RS07685 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC06_RS07700 ENOG4105CJ1 ABC, transporter FOC06_RS07710 ENOG4107Z3H Transcriptional regulator, TetR family FOC06_RS07725 ENOG4105C1G acyl-Coa dehydrogenase FOC06_RS07730 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC06_RS07735 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC06_RS07740 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC06_RS07745 ENOG4105E39 Enoyl-CoA hydratase FOC06_RS07750 ENOG4107QX3 carboxylase FOC06_RS07755 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC06_RS07765 ENOG4105WCN acetyltransferase FOC06_RS07770 ENOG4105DBI uridine monophosphokinase FOC06_RS07785 ENOG4105DZ1 carboxypeptidase FOC06_RS07800 ENOG4105T9C HD domain FOC06_RS07810 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC06_RS07850 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC06_RS07850 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC06_RS07865 ENOG4105FQP Beta-lactamase FOC06_RS07875 ENOG4107Y80 Major Facilitator superfamily FOC06_RS07890 ENOG4105CUV Homoserine Kinase FOC06_RS07925 ENOG4105CPQ Dehydrogenase FOC06_RS08030 ENOG4105ETU transcriptional activator (TenA FOC06_RS08130 ENOG410667J hydrolase FOC06_RS08140 ENOG4105BZU Histidine kinase FOC06_RS08145 ENOG4107RF6 penicillin-binding protein FOC06_RS08165 ENOG4108JJB ABC transporter FOC06_RS08180 ENOG4108HGU Histidine kinase FOC06_RS08195 ENOG4105CB2 alcohol dehydrogenase FOC06_RS08200 ENOG4105CJN penicillin-binding protein FOC06_RS08210 ENOG4105FQP Beta-lactamase FOC06_RS08245 ENOG4108V4B ThiJ pfpI FOC06_RS08275 ENOG4107Y80 Major Facilitator superfamily FOC06_RS08290 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC06_RS08310 ENOG4107Y9U Membrane FOC06_RS08340 ENOG4105FCD Major Facilitator FOC06_RS08355 ENOG4105E09 nadh pyrophosphatase FOC06_RS08360 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC06_RS08365 ENOG4108Z4K mutator MutT protein FOC06_RS08400 ENOG4108XI2 Domain of unknown function (DUF1963) FOC06_RS08430 ENOG4105KWG Pfam:DUF1696 FOC06_RS08465 ENOG4105PKS Excinuclease abc c subunit domain protein FOC06_RS08505 ENOG4107VFR oxidoreductase FOC06_RS08530 ENOG4105PAD Hydrolase FOC06_RS08550 ENOG4105DY8 decarboxylase FOC06_RS08565 ENOG4108IUM Glycogen debranching enzyme FOC06_RS08590 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC06_RS08600 ENOG4105FDR Membrane FOC06_RS08635 ENOG4108V3A UPF0421 protein FOC06_RS08655 ENOG4105MSI germination protein ypeb FOC06_RS08675 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FOC06_RS08680 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC06_RS08685 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FOC06_RS08690 ENOG4107Z3H Transcriptional regulator, TetR family FOC06_RS08720 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC06_RS08735 ENOG4105E98 transcriptional regulator DeoR family FOC06_RS08755 ENOG41062ES Transcriptional regulator FOC06_RS08775 ENOG4107QKR Dehydrogenase FOC06_RS08785 ENOG4107RUY (E1 component), alpha subunit FOC06_RS08795 ENOG4105E1F short-chain dehydrogenase reductase FOC06_RS08800 ENOG4105RHY Pfam:UPF0157 FOC06_RS08830 ENOG4107SQ8 Glycine betaine FOC06_RS08835 ENOG4108IJ7 Glycine betaine FOC06_RS08860 ENOG4105E66 phosphoriboisomerase A FOC06_RS08865 ENOG41082BV acetyltransferase FOC06_RS08870 ENOG4108M1A Chitin-binding protein FOC06_RS08905 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC06_RS08955 ENOG4105EEM helicase FOC06_RS08975 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC06_RS09020 ENOG4108M1A Chitin-binding protein FOC06_RS09040 ENOG4105BZG amino acid carrier protein FOC06_RS09045 ENOG4105C26 Dehydrogenase FOC06_RS09050 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC06_RS09055 ENOG4105CTU Proline racemase FOC06_RS09060 ENOG4105CTU Proline racemase FOC06_RS09065 ENOG41080HI glycine oxidase FOC06_RS09105 ENOG4107T5V SNARE associated Golgi FOC06_RS09120 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC06_RS09125 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC06_RS09140 ENOG4105DTQ mandelate racemase muconate lactonizing FOC06_RS09185 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC06_RS09190 ENOG4105BZU Histidine kinase FOC06_RS09230 ENOG4105DPN Oligoendopeptidase f FOC06_RS09245 ENOG4105EPR degv family FOC06_RS09285 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC06_RS09290 ENOG4106K7D Major facilitator family transporter FOC06_RS09310 ENOG4107BMA Transglycosylase associated protein FOC06_RS09325 ENOG41089UC methyltransferase, type 11 FOC06_RS09360 ENOG4105CHM Aminotransferase FOC06_RS09430 ENOG4105C02 permease FOC06_RS09440 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC06_RS09445 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC06_RS09450 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC06_RS09475 ENOG4105E09 nadh pyrophosphatase FOC06_RS09495 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC06_RS09545 ENOG4107VC0 DNA alkylation repair enzyme FOC06_RS09555 ENOG4107VMI polysaccharide deacetylase FOC06_RS09565 ENOG4108ZCF integral membrane protein FOC06_RS09570 ENOG4105E0M Sulfatase FOC06_RS09575 ENOG4105C5H ABC transporter FOC06_RS09585 ENOG4105EYF MMPL domain protein FOC06_RS09590 ENOG4105EYF MMPL domain protein FOC06_RS09595 ENOG4105EYF MMPL domain protein FOC06_RS09600 ENOG41082JN Transcriptional regulator FOC06_RS09620 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC06_RS09625 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC06_RS09630 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC06_RS09665 ENOG41069ER domain protein FOC06_RS09675 ENOG4105EMN RNA polymerase sigma factor FOC06_RS09700 ENOG4105D4B ABC, transporter FOC06_RS09710 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC06_RS09720 ENOG4105DKT Transcriptional regulator FOC06_RS09735 ENOG41061GT Aldolase FOC06_RS09755 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC06_RS09785 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC06_RS09790 ENOG4105II7 pyrroline-5-carboxylate reductase FOC06_RS09800 ENOG4107258 Transcriptional regulator FOC06_RS09810 ENOG4105E0Y RtcB Protein FOC06_RS09815 ENOG4105ECK Fatty Acid Desaturase FOC06_RS09820 ENOG4105G6Z alkaline phosphatase FOC06_RS09830 ENOG4105VMP Transcriptional regulator FOC06_RS09845 ENOG41090T1 Membrane FOC06_RS09855 ENOG4108WCX response regulator FOC06_RS09865 ENOG41068WN FOC06_RS09890 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC06_RS09915 ENOG4105CKK Glycosyl transferase, family 2 FOC06_RS09940 ENOG4105CKK Glycosyl transferase, family 2 FOC06_RS09950 ENOG4105C8Y Acetylornithine aminotransferase FOC06_RS09990 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC06_RS10000 ENOG4108TVJ Nitroreductase FOC06_RS10005 ENOG4105FS7 Transcriptional regulator FOC06_RS10040 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC06_RS10050 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC06_RS10080 ENOG4108XET gCN5-related N-acetyltransferase FOC06_RS10160 ENOG410635A Membrane FOC06_RS10165 ENOG4105KNA -acetyltransferase FOC06_RS10170 ENOG4108IQI permease FOC06_RS10180 ENOG4105F1N DNA alkylation repair FOC06_RS10225 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC06_RS10260 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC06_RS10265 ENOG4107258 Transcriptional regulator FOC06_RS10275 ENOG4106N3A copper homeostasis protein cutc FOC06_RS10280 ENOG4108ZRV stage ii sporulation protein p FOC06_RS10285 ENOG4108ZHR arsR family transcriptional regulator FOC06_RS10295 ENOG4105FDT acyl-CoA dehydrogenase FOC06_RS10310 ENOG4105DWD nucleoside recognition domain protein FOC06_RS10340 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC06_RS10400 ENOG4105E2A Dehydrogenase FOC06_RS10415 ENOG4108IJ0 Aspartate ammonia-lyase FOC06_RS10420 ENOG4105HDK L-asparaginase FOC06_RS10425 ENOG4108IMY Transcriptional regulator FOC06_RS10435 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC06_RS10440 ENOG4105CUB amino acid FOC06_RS10450 ENOG4105II7 pyrroline-5-carboxylate reductase FOC06_RS10460 ENOG4105C6K Malic enzyme FOC06_RS10495 ENOG4105CSV Glutaminase FOC06_RS10530 ENOG4105CGH 5'-nucleotidase FOC06_RS10535 ENOG4105CH6 catalase FOC06_RS10545 ENOG4105CHJ isochorismatase hydrolase FOC06_RS10570 ENOG41090MY MarR family Transcriptional regulator FOC06_RS10605 ENOG4108606 TspO/MBR family FOC06_RS10610 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC06_RS10625 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC06_RS10630 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC06_RS10645 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC06_RS10650 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC06_RS10655 ENOG4105DSE periplasmic solute binding protein FOC06_RS10660 ENOG4105CC5 ABC transporter FOC06_RS10665 ENOG4105DIK (ABC) transporter FOC06_RS10695 ENOG4105D6J arsenicaL-resistance protein FOC06_RS10700 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC06_RS10705 ENOG41085FC arsR family transcriptional regulator FOC06_RS10720 ENOG4105F7F Chaperone FOC06_RS10730 ENOG4105CHR reductase FOC06_RS10735 ENOG4108YXU transcriptional regulator AsnC family FOC06_RS10810 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC06_RS10815 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC06_RS10825 ENOG4105IIP Membrane FOC06_RS10840 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_RS10845 ENOG41062D9 Histidine kinase FOC06_RS10870 ENOG4105K6H D-cysteine desulfhydrase FOC06_RS10890 ENOG4105VZ8 Transcriptional regulator FOC06_RS10905 ENOG4108NNI Beta-lactamase domain-containing protein FOC06_RS10910 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC06_RS10920 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC06_RS10925 ENOG4105JQZ Methyltransferase FOC06_RS10940 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC06_RS10945 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC06_RS10960 ENOG4105BZU Histidine kinase FOC06_RS10975 ENOG4108U05 Transcriptional regulator FOC06_RS10990 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC06_RS10995 ENOG4105DJB Major Facilitator Superfamily FOC06_RS11000 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FOC06_RS11005 ENOG4107QR9 Iron-sulfur cluster binding protein FOC06_RS11015 ENOG4106P55 Transcriptional regulator FOC06_RS11025 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC06_RS11055 ENOG4105TRI Hydrolase FOC06_RS11085 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC06_RS11115 ENOG4107QJQ Mate efflux family protein FOC06_RS11135 ENOG4105EQ0 Major Facilitator superfamily FOC06_RS11140 ENOG4108JGH Tetr family transcriptional regulator FOC06_RS11155 ENOG4105C44 Serine transporter FOC06_RS11160 ENOG4105EJQ L-serine dehydratase FOC06_RS11175 ENOG4108JPW Aminotransferase FOC06_RS11190 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC06_RS11200 ENOG4105DVH amino acid FOC06_RS11215 ENOG4108JQ1 Dehydrogenase FOC06_RS11235 ENOG4108AEY RNA polymerase sigma factor FOC06_RS11250 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC06_RS11255 ENOG410874W AraC family transcriptional regulator FOC06_RS11305 ENOG4108ISG Major Facilitator FOC06_RS11315 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC06_RS11320 ENOG4105CZM Major Facilitator FOC06_RS11340 ENOG4105DA5 (ABC) transporter FOC06_RS11345 ENOG41069JR FOC06_RS11355 ENOG4105RXJ FOC06_RS11360 ENOG4105KPY Small multidrug resistance protein FOC06_RS11365 ENOG4105KBX Transcriptional regulator, TetR family FOC06_RS11375 ENOG4105CRW Short chain fatty acid transporter FOC06_RS11385 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC06_RS11415 ENOG4108JJB ABC transporter FOC06_RS11420 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC06_RS11445 ENOG4108K8S endonuclease I FOC06_RS11460 ENOG41067QW Transcriptional regulator FOC06_RS11470 ENOG4108Z66 YbaK ebsC protein FOC06_RS11475 ENOG4105CUT histidyl-tRNA synthetase FOC06_RS11490 ENOG4105KVH Transcriptional regulator FOC06_RS11495 ENOG4108RCM Nitroreductase FOC06_RS11515 ENOG4108PSK reductase FOC06_RS11525 ENOG4105CJ1 ABC, transporter FOC06_RS11585 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC06_RS11590 ENOG4105DKQ ROK family FOC06_RS11595 ENOG4106UW1 Major Facilitator superfamily FOC06_RS11600 ENOG4108UW5 maltose o-acetyltransferase FOC06_RS11610 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC06_RS11615 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC06_RS11620 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC06_RS11640 ENOG4105DMQ Methyltransferase FOC06_RS11650 ENOG4105EV4 Multidrug resistance protein mdtH FOC06_RS11680 ENOG4105C37 (CBS) domain FOC06_RS11695 ENOG4105DDN Pentapeptide repeat-containing protein FOC06_RS11700 ENOG4105XDF Protein of unknown function (DUF1272) FOC06_RS11705 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC06_RS11710 ENOG4105CMG Carbohydrate kinase FOC06_RS11715 ENOG4105C6Z Gluconate FOC06_RS11720 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC06_RS11735 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC06_RS11740 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC06_RS11745 ENOG4105CIS alcohol dehydrogenase FOC06_RS11750 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC06_RS11765 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC06_RS11770 ENOG4105D4Y metalloprotease FOC06_RS11790 ENOG4105CV8 reductase FOC06_RS11795 ENOG4105F27 Major Facilitator FOC06_RS11810 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC06_RS11815 ENOG4105C44 Serine transporter FOC06_RS11845 ENOG4105KVH Transcriptional regulator FOC06_RS11850 ENOG4108TZY GntR Family Transcriptional Regulator FOC06_RS11860 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC06_RS11865 ENOG4105KVH Transcriptional regulator FOC06_RS11870 ENOG4105KVH Transcriptional regulator FOC06_RS11905 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC06_RS11915 ENOG4105CHR reductase FOC06_RS11935 ENOG4105KVH Transcriptional regulator FOC06_RS12005 ENOG4105KAF membrAne FOC06_RS12030 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC06_RS12045 ENOG4107YXZ hydrolase, family 25 FOC06_RS12070 ENOG4105ED2 Beta-lactamase FOC06_RS12080 ENOG4105H3G oxidoreductase FOC06_RS12150 ENOG4108TN2 lmbE family FOC06_RS12160 ENOG4107R3E Citrate transporter FOC06_RS12180 ENOG4108MES Periplasmic binding protein FOC06_RS12185 ENOG4105EHG Permease protein FOC06_RS12190 ENOG4105DQ5 transport system permease protein FOC06_RS12195 ENOG4105NX3 Membrane FOC06_RS12200 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC06_RS12220 ENOG4107CUJ Protein of unknown function (DUF2690) FOC06_RS12230 ENOG4107V2S Transcriptional regulator FOC06_RS12250 ENOG4105C98 muts2 protein FOC06_RS12260 ENOG4105E5K Alpha-amylase FOC06_RS12270 ENOG4105DPN Oligoendopeptidase f FOC06_RS12275 ENOG4108A04 Beta-lactamase FOC06_RS12305 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC06_RS12330 ENOG41082BM Transcriptional regulator, arsr family FOC06_RS12335 ENOG4105CIS alcohol dehydrogenase FOC06_RS12360 ENOG4105RHY Pfam:UPF0157 FOC06_RS12370 ENOG4105C09 Bile acid FOC06_RS12375 ENOG4105CQB FAD linked oxidase domain protein FOC06_RS12395 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC06_RS12405 ENOG4105K64 Glycosyl transferase, family 2 FOC06_RS12410 ENOG4105E39 Enoyl-CoA hydratase FOC06_RS12420 ENOG4105KT7 mgtC SapB transporter FOC06_RS12435 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC06_RS12440 ENOG41073R8 VanW family FOC06_RS12450 ENOG4108R1P FOC06_RS12465 ENOG4105VEQ Cold shock protein FOC06_RS12485 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC06_RS12505 ENOG410904N short-chain dehydrogenase reductase FOC06_RS12515 ENOG4106IQC argininosuccinate lyase FOC06_RS12530 ENOG4108IA2 Sodium pantothenate symporter FOC06_RS12540 ENOG4105C26 Dehydrogenase FOC06_RS12545 ENOG4105CHR reductase FOC06_RS12555 ENOG4105EWU Squalene--hopene cyclase FOC06_RS12565 ENOG4105FR1 rard protein FOC06_RS12570 ENOG410696E Membrane FOC06_RS12585 ENOG4105D1F ATP-binding protein FOC06_RS12595 ENOG4108ZAF Molybdopterin FOC06_RS12600 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC06_RS12605 ENOG4105D06 uba thif-type nad fad binding protein FOC06_RS12610 ENOG4105TMB Formate nitrite transporter FOC06_RS12620 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC06_RS12625 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC06_RS12635 ENOG4108JB9 formate dehydrogenase FOC06_RS12640 ENOG4105E1K spore germination protein FOC06_RS12705 ENOG4108KGH TRANSCRIPTIONal FOC06_RS12715 ENOG4105EMN RNA polymerase sigma factor FOC06_RS12730 ENOG4105CIG ABC transporter FOC06_RS12740 ENOG4105D9R oxidoreductase FOC06_RS12750 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC06_RS12755 ENOG4105K4P CoA-binding domain protein FOC06_RS12760 ENOG4105C0H protease FOC06_RS12765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_RS12775 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC06_RS12780 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC06_RS12785 ENOG4105W8X HesB YadR YfhF-family protein FOC06_RS12815 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC06_RS12820 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC06_RS12830 ENOG4108JJA ABC, transporter FOC06_RS12835 ENOG4108I0Z Aconitate hydratase FOC06_RS12875 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC06_RS12895 ENOG4107F3J Amp-dependent synthetase and ligase FOC06_RS12900 ENOG4107ZYJ bioY protein FOC06_RS12905 ENOG4105CEY Amp-dependent synthetase and ligase FOC06_RS12955 ENOG4107AYK membrAne FOC06_RS12965 ENOG4105BZU Histidine kinase FOC06_RS12970 ENOG4105FBA Phospholipase Carboxylesterase FOC06_RS12975 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC06_RS12980 ENOG4105CK7 Sodium proline symporter FOC06_RS12985 ENOG4105CBC glutamate synthase FOC06_RS12990 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC06_RS12995 ENOG4108VJ1 Transcriptional regulator (CarD family FOC06_RS13000 ENOG4108903 Formimidoylglutamase FOC06_RS13025 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC06_RS13085 ENOG4107QIV Cytochrome c biogenesis protein FOC06_RS13095 ENOG4107RSM transcriptional regulator FOC06_RS13100 ENOG4105VAW lrga family FOC06_RS13105 ENOG41067MG lrgb family FOC06_RS13130 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC06_RS13145 ENOG4105BZ1 (ABC) transporter FOC06_RS13150 ENOG4105BZ1 (ABC) transporter FOC06_RS13170 ENOG4105D7V transposase FOC06_RS13185 ENOG4105D5T phosphonate abc transporter FOC06_RS13205 ENOG4108SVB resolvase FOC06_RS13225 ENOG4105K7K Transcriptional regulator FOC06_RS13255 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOC06_RS13260 ENOG4105XSJ toxin secretion phage lysis holin FOC06_RS13445 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FOC06_RS13545 ENOG4105C5F glutamine synthetase FOC06_RS13550 ENOG4105KV4 Transcriptional regulator FOC06_RS13555 ENOG4105CXI aluminum resistance protein FOC06_RS13565 ENOG4105EN6 Membrane FOC06_RS13575 ENOG4106F1P AAA ATPase, central domain protein FOC06_RS13605 ENOG41069ER domain protein FOC06_RS13610 ENOG4105DM4 PTS System FOC06_RS13615 ENOG4105DE4 1-phosphofructokinase FOC06_RS13620 ENOG4105E98 transcriptional regulator DeoR family FOC06_RS13630 ENOG4108SJC Membrane FOC06_RS13640 ENOG4105C85 amino acid FOC06_RS13655 ENOG4105TMB Formate nitrite transporter FOC06_RS13660 ENOG4105K70 DNA-binding protein FOC06_RS13665 ENOG4105C59 p-type ATPase FOC06_RS13670 ENOG410681U heavy metal transport detoxification protein FOC06_RS13675 ENOG4105VPX protein, conserved in bacteria FOC06_RS13685 ENOG4105NIV Esterase FOC06_RS13690 ENOG4105E0A ABC, transporter FOC06_RS13710 ENOG4105CGK Exodeoxyribonuclease III FOC06_RS13720 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC06_RS13725 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC06_RS13755 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC06_RS13760 ENOG4105BZU Histidine kinase FOC06_RS13775 ENOG41067MG lrgb family FOC06_RS13790 ENOG4107TTQ Alpha beta hydrolase fold FOC06_RS13795 ENOG4107YEI lmbE family FOC06_RS13820 ENOG4105F0V Cell wall hydrolase FOC06_RS13825 ENOG4107R6R udp-galactopyranose mutase FOC06_RS13830 ENOG4105E0M Sulfatase FOC06_RS13835 ENOG410890F Dynamin family FOC06_RS13845 ENOG4107QHE Choloylglycine hydrolase FOC06_RS13870 ENOG4105DA5 (ABC) transporter FOC06_RS13895 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC06_RS13900 ENOG4105DQU oxidoreductase, subunit beta FOC06_RS13905 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC06_RS13910 ENOG4108IGT Dipeptidase FOC06_RS13915 ENOG4105MCT stage V sporulation protein S FOC06_RS13920 ENOG4105D48 metallophosphoesterase FOC06_RS13945 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC06_RS13960 ENOG4105XZV Protein of unknown function (DUF3243) FOC06_RS13965 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC06_RS13990 ENOG4108JQ9 ABC transporter FOC06_RS13995 ENOG4105DIH basic membrane FOC06_RS14000 ENOG4105FDP GntR family transcriptional regulator FOC06_RS14005 ENOG4107QZI cell division protein FtsK FOC06_RS14015 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC06_RS14025 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC06_RS14035 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC06_RS14040 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC06_RS14045 ENOG4105E35 Dipicolinate synthase subunit A FOC06_RS14055 ENOG4105C1V Peptidase, M16 FOC06_RS14075 ENOG4105DTN riboflavin biosynthesis protein ribF FOC06_RS14080 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC06_RS14090 ENOG4105W7A Protein of unknown function (DUF503) FOC06_RS14100 ENOG4105VHM ribosomal protein FOC06_RS14105 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC06_RS14110 ENOG4105CHV Transcription elongation factor NusA FOC06_RS14120 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC06_RS14130 ENOG4105DZP Membrane-associated zinc metalloprotease FOC06_RS14135 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC06_RS14140 ENOG4105KNE Phosphatidate cytidylyltransferase FOC06_RS14145 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC06_RS14185 ENOG4108HE4 integrase family FOC06_RS14195 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC06_RS14205 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC06_RS14220 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC06_RS14245 ENOG4105VB6 UPF0109 protein FOC06_RS14265 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC06_RS14270 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC06_RS14285 ENOG4105CHR reductase FOC06_RS14290 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC06_RS14305 ENOG4105CB5 ATP-dependent DNA helicase recG FOC06_RS14310 ENOG4105DP4 dak2 domain fusion protein ylov FOC06_RS14315 ENOG4108ZAA Alkaline-shock protein FOC06_RS14330 ENOG4105FJ0 thiamine FOC06_RS14335 ENOG4105DJV ribulose-phosphate 3-epimerase FOC06_RS14340 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC06_RS14345 ENOG4105D9P serine threonine protein kinase FOC06_RS14350 ENOG4108ZF3 Phosphatase FOC06_RS14360 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC06_RS14370 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC06_RS14375 ENOG4105C25 Primosomal protein n' FOC06_RS14380 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC06_RS14400 ENOG4105DSJ YicC domain protein FOC06_RS14410 ENOG4105F23 Fibronectin-binding protein FOC06_RS14415 ENOG4105DC7 peptidase M24 FOC06_RS14470 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOC06_RS14495 ENOG4105C34 Pseudouridine synthase FOC06_RS14520 ENOG4105DBK s4 domain protein FOC06_RS14525 ENOG41067XK integral membrane protein FOC06_RS14535 ENOG4105DFA alanine racemase domain protein FOC06_RS14540 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC06_RS14545 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC06_RS14555 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC06_RS14565 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC06_RS14570 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC06_RS14575 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC06_RS14580 ENOG4105D4A Cell wall formation (By similarity) FOC06_RS14585 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC06_RS14590 ENOG4105CNI cell division protein FtsW FOC06_RS14605 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC06_RS14610 ENOG4105CJN penicillin-binding protein FOC06_RS14615 ENOG4105CJN penicillin-binding protein FOC06_RS14620 ENOG41068DC Essential cell division protein (By similarity) FOC06_RS14660 ENOG4105KNH Nucleic acid-binding protein FOC06_RS14710 ENOG4105XSJ toxin secretion phage lysis holin FOC06_RS14790 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC06_RS14800 ENOG4105CAR Terminase, large subunit FOC06_RS14885 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOC06_RS14900 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC06_RS14945 ENOG4108IMY Transcriptional regulator FOC06_RS14965 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC06_RS14975 ENOG41063PX domain protein FOC06_RS14980 ENOG4105D78 K07001 NTE family protein FOC06_RS14985 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC06_RS14995 ENOG4106H78 methyltransferase FOC06_RS15015 ENOG4107TB6 phosphoglycerate mutase FOC06_RS15030 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC06_RS15080 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC06_RS15100 ENOG4108IAB Phoh family FOC06_RS15120 ENOG4105QA2 FOC06_RS15125 ENOG4105CI3 gtp-binding protein typa FOC06_RS15135 ENOG4105ECY inositol monophosphatase FOC06_RS15155 ENOG4105CXN decarboxylase FOC06_RS15200 ENOG4105C7S Dehydrogenase FOC06_RS15205 ENOG4105CPP Dehydrogenase, E1 component FOC06_RS15220 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC06_RS15235 ENOG4105CN5 Metallo-Beta-Lactamase FOC06_RS15240 ENOG4107ZYR domain protein FOC06_RS15275 ENOG4108XRC Protein of unknown function (DUF458) FOC06_RS15280 ENOG4107IN1 Protein of unknown function (DUF1797) FOC06_RS15295 ENOG4105EPM Diguanylate phosphodiesterase FOC06_RS15300 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC06_RS15315 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC06_RS15325 ENOG4105UIN FOC06_RS15380 ENOG4108HGU Histidine kinase FOC06_RS15390 ENOG4105CHM Aminotransferase FOC06_RS15395 ENOG4105FKQ transcriptional regulator FOC06_RS15400 ENOG4105EG2 ABC transporter, permease FOC06_RS15410 ENOG4107FKK extracellular solute-binding protein family 1 FOC06_RS15420 ENOG4105CG3 alpha amylase, catalytic region FOC06_RS15465 ENOG4105CHU acetyl-coa acetyltransferase FOC06_RS15505 ENOG4105K7K Transcriptional regulator FOC06_RS15510 ENOG4105DTD Dehydrogenase FOC06_RS15520 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FOC06_RS15530 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC06_RS15555 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOC06_RS15575 ENOG4106TD9 Diguanylate cyclase FOC06_RS15595 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC06_RS15610 ENOG4105CID antiterminator FOC06_RS15620 ENOG4105FDP GntR family transcriptional regulator FOC06_RS15630 ENOG4105CE4 GlcNAc 6-P deacetylase FOC06_RS15665 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC06_RS15670 ENOG4105PTM secreted protein FOC06_RS15675 ENOG4105J7I hydrolase FOC06_RS15685 ENOG4105G6R Stage v sporulation protein ae FOC06_RS15695 ENOG4105CZ3 stage V sporulation protein ad FOC06_RS15700 ENOG41090VF Stage v sporulation protein ac FOC06_RS15720 ENOG4105C8J )-transporter FOC06_RS15725 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC06_RS15735 ENOG41082AN stage II sporulation protein FOC06_RS15740 ENOG4105DZ1 carboxypeptidase FOC06_RS15745 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC06_RS15750 ENOG4105DVE abc transporter atp-binding protein FOC06_RS15780 ENOG4105D7N magnesium and cobalt transport protein CorA FOC06_RS15805 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC06_RS15815 ENOG4105I3K Ferric uptake regulator, Fur family FOC06_RS15820 ENOG4105MZ9 stage II sporulation protein m FOC06_RS15840 ENOG4105CPC Aldo Keto reductase FOC06_RS15850 ENOG4105RHY Pfam:UPF0157 FOC06_RS15870 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC06_RS15880 ENOG4105ETE Transcriptional regulator (LacI family FOC06_RS15885 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC06_RS15905 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC06_RS15910 ENOG4108R6K riboflavin synthase, subunit alpha FOC06_RS15930 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FOC06_RS15935 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC06_RS15940 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC06_RS15945 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC06_RS15955 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC06_RS15965 ENOG4105DFD Na H antiporter FOC06_RS15970 ENOG4105CGH 5'-nucleotidase FOC06_RS16010 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC06_RS16025 ENOG4108IXY short-chain dehydrogenase reductase FOC06_RS16035 ENOG4105II7 pyrroline-5-carboxylate reductase FOC06_RS16040 ENOG4105EJQ L-serine dehydratase FOC06_RS16065 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC06_RS16075 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC06_RS16080 ENOG4105D9U N-acetyltransferase FOC06_RS16095 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC06_RS16100 ENOG4108QEG Membrane FOC06_RS16105 ENOG4105CDA abc transporter atp-binding protein FOC06_RS16110 ENOG4105E5Q amino acid AbC transporter FOC06_RS16115 ENOG4108HW3 (ABC) transporter FOC06_RS16125 ENOG4105G7B Protein of unknown function (DUF2992) FOC06_RS16140 ENOG4105C7S Dehydrogenase FOC06_RS16145 ENOG4105CPP Dehydrogenase, E1 component FOC06_RS16165 ENOG4107RDP Dehydrogenase FOC06_RS16175 ENOG4108JUB Transcriptional regulator FOC06_RS16185 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC06_RS16200 ENOG4107QQR Sporulation FOC06_RS16205 ENOG4105S1Z Stage IV sporulation protein B FOC06_RS16210 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC06_RS16220 ENOG4105DX0 Hemolysin A FOC06_RS16230 ENOG4105CTB Polyprenyl synthetase FOC06_RS16255 ENOG4108ZSR alkaline shock protein FOC06_RS16260 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC06_RS16285 ENOG410644B Stage III sporulation protein af FOC06_RS16295 ENOG4105KQ4 Stage iii sporulation protein ad FOC06_RS16300 ENOG4108CQH stage III sporulation protein AC FOC06_RS16305 ENOG4105KR5 Stage iii sporulation protein FOC06_RS16310 ENOG4105CD2 stage iii sporulation protein aa FOC06_RS16335 ENOG4105DC7 peptidase M24 FOC06_RS16350 ENOG4105CBJ Metal-dependent enzyme FOC06_RS16360 ENOG4107YBY Hydrolase FOC06_RS16380 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC06_RS16385 ENOG4105WZW rhodanese family FOC06_RS16405 ENOG41080TC multidrug resistance protein FOC06_RS16440 ENOG4105CJ1 ABC, transporter FOC06_RS16445 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC06_RS16475 ENOG4105C0D helicase FOC06_RS16595 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC06_RS16600 ENOG4105C3R Methionine synthase FOC06_RS16610 ENOG4105C28 cystathionine FOC06_RS16615 ENOG4105C28 cystathionine FOC06_RS16635 ENOG4105C5X domain protein FOC06_RS16645 ENOG4105DKQ ROK family FOC06_RS16655 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC06_RS16670 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC06_RS16675 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC06_RS16680 ENOG4105E2Z phosphate ABC transporter (Permease FOC06_RS16685 ENOG4105C8U phosphate abc transporter FOC06_RS16690 ENOG4105PWN phosphate abc transporter FOC06_RS16695 ENOG4107RF6 penicillin-binding protein FOC06_RS16705 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC06_RS16730 ENOG4105N80 Ferric uptake regulator, Fur family FOC06_RS16740 ENOG4105FDK ABC transporter FOC06_RS16745 ENOG4108JYZ YitT family FOC06_RS16750 ENOG41069ZM Protein of unknown function (DUF2624) FOC06_RS16775 ENOG4105EGD dinuclear metal center protein, YbgI family FOC06_RS16790 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC06_RS16795 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC06_RS16820 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC06_RS16825 ENOG4105KG3 cytidine deaminase FOC06_RS16830 ENOG4107YR5 Diacylglycerol kinase FOC06_RS16840 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC06_RS16845 ENOG4105C9A Phoh family FOC06_RS16855 ENOG41068P3 sporulation protein YqfC FOC06_RS16860 ENOG4105KTH gatB Yqey FOC06_RS16870 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC06_RS16875 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC06_RS16895 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOC06_RS16905 ENOG4105CSA Coproporphyrinogen iii oxidase FOC06_RS16910 ENOG4105KVH Transcriptional regulator FOC06_RS16935 ENOG4105TQK DNA polymerase iii, delta' subunit FOC06_RS16945 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC06_RS16950 ENOG4108UK2 deaminase FOC06_RS16955 ENOG4105KQC Competence protein FOC06_RS16965 ENOG4105DXX methyltransferase FOC06_RS16975 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC06_RS16985 ENOG410812S Rna-binding protein FOC06_RS16995 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC06_RS17000 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC06_RS17015 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC06_RS17035 ENOG4108TVJ Nitroreductase FOC06_RS17050 ENOG4105G6Z alkaline phosphatase FOC06_RS17060 ENOG4108MUZ hydrolase FOC06_RS17095 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC06_RS17100 ENOG4105MIR Phenylalanine 4-monooxygenase FOC06_RS17150 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC06_RS17155 ENOG4108V5C ABC transporter FOC06_RS17165 ENOG4108EKI Dehydrogenase FOC06_RS17170 ENOG4105C28 cystathionine FOC06_RS17200 ENOG4107XRG penicillin-binding protein FOC06_RS17215 ENOG4105CFP Peptidase U32 FOC06_RS17220 ENOG4105XYU peptidase (U32 family) FOC06_RS17225 ENOG4108VQJ O-methyltransferase FOC06_RS17230 ENOG4105HHA aminodeoxychorismate lyase FOC06_RS17250 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC06_RS17260 ENOG4105C02 permease FOC06_RS17275 ENOG41060CR FOC06_RS17280 ENOG4105C7H Helicase, RecD TraA family FOC06_RS17290 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC06_RS17295 ENOG4105C3J Cysteine desulfurase FOC06_RS17305 ENOG4105D1H recombination factor protein RarA FOC06_RS17310 ENOG4108VCI transcription factor, rsfa family FOC06_RS17315 ENOG4105CUZ uba thif-type nad fad binding protein FOC06_RS17325 ENOG4105CUT histidyl-tRNA synthetase FOC06_RS17335 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC06_RS17345 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC06_RS17350 ENOG41076HS cation diffusion facilitator family transporter FOC06_RS17355 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC06_RS17365 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC06_RS17370 ENOG4108QG2 Membrane FOC06_RS17380 ENOG4105VIE preprotein translocase, subunit YajC FOC06_RS17395 ENOG41061AI Protein of unknown function (DUF2905) FOC06_RS17410 ENOG4108HUF Transporter FOC06_RS17420 ENOG4108IPJ Membrane FOC06_RS17425 ENOG4108IPJ Membrane FOC06_RS17430 ENOG41082BM Transcriptional regulator, arsr family FOC06_RS17455 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC06_RS17460 ENOG4108IYU L-aspartate oxidase FOC06_RS17475 ENOG4108RPX mosc domain containing protein FOC06_RS17480 ENOG4105CQC Prephenate dehydratase FOC06_RS17510 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC06_RS17525 ENOG4105X36 (ribosomal) protein FOC06_RS17535 ENOG4105C03 ribonuclease FOC06_RS17550 ENOG4107QMS site-determining protein FOC06_RS17565 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOC06_RS17570 ENOG4105DFF Rod shape-determining protein mreb FOC06_RS17590 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC06_RS17595 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC06_RS17605 ENOG41068KH stage VI sporulation protein D FOC06_RS17615 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC06_RS17640 ENOG4105K56 Transcriptional regulator FOC06_RS17660 ENOG4108IUQ atp-dependent protease FOC06_RS17685 ENOG4108QCI YvbH-like oligomerisation region FOC06_RS17705 ENOG4105M59 Phosphodiesterase, mj0936 family FOC06_RS17710 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOC06_RS17720 ENOG4108XJQ germination protein FOC06_RS17730 ENOG4108PCX Major Facilitator FOC06_RS17740 ENOG4105KBX Transcriptional regulator, TetR family FOC06_RS17755 ENOG4105PFC Transcriptional regulator FOC06_RS17770 ENOG4105DZC cytosine deaminase FOC06_RS17775 ENOG4105DZC cytosine deaminase FOC06_RS17780 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC06_RS17785 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC06_RS17800 ENOG4108JQ7 (ABC) transporter FOC06_RS17810 ENOG4105DY9 regulatoR FOC06_RS17825 ENOG41067S9 phage shock protein C, PspC FOC06_RS17830 ENOG4108JCI Transcriptional regulator FOC06_RS17840 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC06_RS17845 ENOG4108Z40 Transcriptional regulator FOC06_RS17850 ENOG4105RHA ABC transporter, permease FOC06_RS17855 ENOG4108IUX (ABC) transporter FOC06_RS17860 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC06_RS17870 ENOG4105E14 MotA TolQ exbB proton channel FOC06_RS17875 ENOG4108VXD carboxy-peptidase FOC06_RS17885 ENOG4105E33 succinate dehydrogenase FOC06_RS17895 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC06_RS17910 ENOG4105K63 Thioredoxin FOC06_RS17915 ENOG4105C10 Electron transfer flavoprotein FOC06_RS17920 ENOG4105BZJ Electron transfer flavoprotein FOC06_RS17925 ENOG41060WC Enoyl-CoA hydratase FOC06_RS17930 ENOG4107Z3H Transcriptional regulator, TetR family FOC06_RS17935 ENOG4105CEY Amp-dependent synthetase and ligase FOC06_RS17945 ENOG4105J76 Periplasmic binding protein FOC06_RS17950 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC06_RS17990 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC06_RS18000 ENOG4105DR4 Methyltransferase FOC06_RS18015 ENOG4105KFN sortase, SrtB family FOC06_RS18020 ENOG4105E0A ABC, transporter FOC06_RS18035 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC06_RS18045 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC06_RS18055 ENOG4105FE9 pseudouridine synthase FOC06_RS18065 ENOG4105DCG PHP domain protein FOC06_RS18100 ENOG4105C5S asparaginyl-tRNA synthetase FOC06_RS18105 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC06_RS18115 ENOG4108RWN rrna methyltransferase FOC06_RS18150 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC06_RS18155 ENOG4105CW7 secretion protein, HlyD family FOC06_RS18160 ENOG4108JGH Tetr family transcriptional regulator FOC06_RS18165 ENOG4105CN9 Peptidase m42 family protein FOC06_RS18185 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC06_RS18190 ENOG4105C22 threonyL-tRNA synthetase FOC06_RS18195 ENOG4108TDW sporulation protein YtxC FOC06_RS18215 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC06_RS18225 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC06_RS18230 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC06_RS18240 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC06_RS18245 ENOG4105C2M dna polymerase I FOC06_RS18250 ENOG4105BZU Histidine kinase FOC06_RS18255 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC06_RS18270 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC06_RS18275 ENOG4105BZN citrate synthase FOC06_RS18285 ENOG4108REF Sporulation integral membrane protein ytvi FOC06_RS18290 ENOG4105FS0 cytoplasmic membrane protein FOC06_RS18315 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC06_RS18320 ENOG4105C6K Malic enzyme FOC06_RS18325 ENOG4105C0B DNA polymerase III (alpha subunit) FOC06_RS18330 ENOG4105VV2 FOC06_RS18340 ENOG4105SFS phosphoesterase RecJ domain protein FOC06_RS18375 ENOG4105DC7 peptidase M24 FOC06_RS18410 ENOG4105Z7P Acetyltransferase (GNAT) family FOC06_RS18415 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC06_RS18425 ENOG4105VZ8 Transcriptional regulator FOC06_RS18445 ENOG4107YZX Universal stress protein FOC06_RS18485 ENOG4108JYZ YitT family FOC06_RS18505 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC06_RS18515 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC06_RS18520 ENOG4105KBJ sporulation protein ytfj FOC06_RS18535 ENOG4105EFZ amidohydrolase FOC06_RS18545 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC06_RS18570 ENOG4106KR7 LysR family Transcriptional regulator FOC06_RS18590 ENOG4105C28 cystathionine FOC06_RS18610 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC06_RS18620 ENOG4105EMN RNA polymerase sigma factor FOC06_RS18640 ENOG4105F1V Acetoin utilization protein FOC06_RS18645 ENOG4105W87 Cbs domain FOC06_RS18650 ENOG4105DGU Histone deacetylase FOC06_RS18660 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC06_RS18670 ENOG4107SNB ankyrin repeat protein YahD FOC06_RS18675 ENOG4105EP9 oxidoreductase FOC06_RS18705 ENOG4105ETE Transcriptional regulator (LacI family FOC06_RS18725 ENOG4105C88 aminopeptidase FOC06_RS18770 ENOG4108VDD TRNA binding domain protein FOC06_RS18800 ENOG4105C8F Beta-lactamase domain protein FOC06_RS18815 ENOG4108V15 phosphotransferase enzyme family FOC06_RS18820 ENOG4108IUM Glycogen debranching enzyme FOC06_RS18835 ENOG4105YW5 deoR family transcriptional regulator FOC06_RS18850 ENOG4105CBX hi0933 family FOC06_RS18885 ENOG4108VJ1 Transcriptional regulator (CarD family FOC06_RS18890 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC06_RS18895 ENOG4105CSC Glucose uptake protein FOC06_RS18910 ENOG4108ZAF Molybdopterin FOC06_RS18915 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC06_RS18920 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC06_RS18930 ENOG4105D06 uba thif-type nad fad binding protein FOC06_RS18955 ENOG41085GJ domain protein FOC06_RS18965 ENOG4105DWV Homoserine O-trans-acetylase FOC06_RS18975 ENOG4108B31 Spore germination protein FOC06_RS19005 ENOG410605W Major Facilitator FOC06_RS19010 ENOG4107S91 Sodium hydrogen exchanger FOC06_RS19015 ENOG4105NCW Trka-c domain protein FOC06_RS19030 ENOG4105C19 ABC transporter FOC06_RS19050 ENOG4105N5T Radical SAM Protein FOC06_RS19060 ENOG4105DA5 (ABC) transporter FOC06_RS19090 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC06_RS19095 ENOG4108Z0R Transferase FOC06_RS19100 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC06_RS19105 ENOG4105BZF Glycosyl transferase (Group 1 FOC06_RS19115 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC06_RS19165 ENOG4105EGD dinuclear metal center protein, YbgI family FOC06_RS19170 ENOG4105BZU Histidine kinase FOC06_RS19175 ENOG4105BZU Histidine kinase FOC06_RS19180 ENOG4107S9D Alpha beta hydrolase FOC06_RS19200 ENOG4105D2X ABC transporter substrate-binding protein FOC06_RS19210 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC06_RS19265 ENOG4108V2W Carbonate dehydratase FOC06_RS19270 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC06_RS19275 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC06_RS19320 ENOG41087YS Phage shock protein A FOC06_RS19355 ENOG4105BZU Histidine kinase FOC06_RS19360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_RS19385 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC06_RS19390 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC06_RS19425 ENOG4107ZTW SNARE associated Golgi FOC06_RS19440 ENOG4105C19 ABC transporter FOC06_RS19445 ENOG41086D8 Transcriptional regulator FOC06_RS19485 ENOG4105C6Z Gluconate FOC06_RS19490 ENOG4105FDP GntR family transcriptional regulator FOC06_RS19510 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC06_RS19540 ENOG4105DTQ mandelate racemase muconate lactonizing FOC06_RS19550 ENOG4108IPT Naphthoate synthase FOC06_RS19555 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC06_RS19560 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOC06_RS19565 ENOG4105E4F Isochorismate synthase FOC06_RS19570 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC06_RS19580 ENOG4105VEQ Cold shock protein FOC06_RS19600 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOC06_RS19610 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOC06_RS19630 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC06_RS19725 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC06_RS19760 ENOG4105KT7 mgtC SapB transporter FOC06_RS19765 ENOG4107PBV potassium channel FOC06_RS19775 ENOG4107QYV phosphohexose isomerase FOC06_RS19780 ENOG4105WG9 Conserved Protein FOC06_RS19790 ENOG4105CHM Aminotransferase FOC06_RS19795 ENOG4108ZB6 transcriptional regulator AsnC family FOC06_RS19800 ENOG4105C5I Dehydrogenase FOC06_RS19805 ENOG4108MUZ hydrolase FOC06_RS19815 ENOG4105C87 Aminotransferase class I and II FOC06_RS19825 ENOG4105Y38 Kinase-associated protein B FOC06_RS19835 ENOG4107R3E Citrate transporter FOC06_RS19850 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FOC06_RS19855 ENOG4105KA0 thioesterase Superfamily protein FOC06_RS19875 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC06_RS19895 ENOG41069ER domain protein FOC06_RS19910 ENOG4105CEP NADH dehydrogenase FOC06_RS19940 ENOG4105EWC Purine nucleoside phosphorylase FOC06_RS19960 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC06_RS19985 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC06_RS19990 ENOG4105C4B ABC transporter, permease FOC06_RS19995 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC06_RS20040 ENOG41083MR nifu domain-containing protein FOC06_RS20055 ENOG4108W5N phosphatidylglycerophosphatase a FOC06_RS20065 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC06_RS20070 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC06_RS20085 ENOG4105CBT Fructose-1,6-bisphosphatase FOC06_RS20100 ENOG4105MMD transcriptional regulator FOC06_RS20105 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC06_RS20110 ENOG4107TXC Transcriptional regulator FOC06_RS20115 ENOG41090T1 Membrane FOC06_RS20140 ENOG4105FAA peptidase M23 FOC06_RS20150 ENOG4105KZD Domain of unknown function (DUF1805) FOC06_RS20155 ENOG4107R8B 5'-nucleotidase FOC06_RS20170 ENOG4105DIW FeS assembly protein SUFB FOC06_RS20175 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC06_RS20180 ENOG4105C9B Cysteine desulfurase FOC06_RS20185 ENOG4105JRK feS assembly protein SufD FOC06_RS20190 ENOG4105C3K feS assembly ATPase SufC FOC06_RS20195 ENOG4105D01 (LipO)protein FOC06_RS20200 ENOG4105D01 (LipO)protein FOC06_RS20205 ENOG4108UMI ABC transporter, permease FOC06_RS20240 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC06_RS20285 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC06_RS20310 ENOG4108W8B Beta-lactamase domain protein FOC06_RS20315 ENOG4105C1G acyl-Coa dehydrogenase FOC06_RS20320 ENOG4105CHU acetyl-coa acetyltransferase FOC06_RS20335 ENOG4105DZ1 carboxypeptidase FOC06_RS20355 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC06_RS20370 ENOG4108SUT Major Facilitator Superfamily FOC06_RS20375 ENOG4107R7I amino acid FOC06_RS20385 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC06_RS20395 ENOG4107AYK membrAne FOC06_RS20430 ENOG4107ZTW SNARE associated Golgi FOC06_RS20440 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC06_RS20445 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_RS20450 ENOG4105BZU Histidine kinase FOC06_RS20460 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC06_RS20475 ENOG4105VG1 fes assembly suf system protein FOC06_RS20480 ENOG4105D4Y metalloprotease FOC06_RS20500 ENOG4107S91 Sodium hydrogen exchanger FOC06_RS20505 ENOG4105NCW Trka-c domain protein FOC06_RS20515 ENOG4108RMU ferritin dps family protein FOC06_RS20530 ENOG4108URH decarboxylase FOC06_RS20550 ENOG4105D9N nucleoside FOC06_RS20555 ENOG4105D9N nucleoside FOC06_RS20570 ENOG4108RYK Nad-dependent epimerase dehydratase FOC06_RS20585 ENOG4105CV8 reductase FOC06_RS20590 ENOG4105F27 Major Facilitator FOC06_RS20595 ENOG4105KVH Transcriptional regulator FOC06_RS20610 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC06_RS20615 ENOG4105D4A Cell wall formation (By similarity) FOC06_RS20625 ENOG4105C8Q Methyl-accepting chemotaxis FOC06_RS20635 ENOG4105WMR Protein CrcB homolog FOC06_RS20640 ENOG4105WMR Protein CrcB homolog FOC06_RS20655 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC06_RS20660 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FOC06_RS20675 ENOG4108IPW abc transporter atp-binding protein FOC06_RS20680 ENOG4105CM4 permease protein FOC06_RS20710 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC06_RS20720 ENOG4105XZU Preprotein translocase, subunit SecG FOC06_RS20725 ENOG41067MG lrgb family FOC06_RS20820 ENOG4105EFC phage portal protein HK97 family FOC06_RS20845 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC06_RS20855 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC06_RS20860 ENOG4105CP7 Triose-phosphate isomerase FOC06_RS20885 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC06_RS20905 ENOG41090VF Stage v sporulation protein ac FOC06_RS20910 ENOG4105CZ3 stage V sporulation protein ad FOC06_RS20925 ENOG4105H67 Protein of unknown function (DUF421) FOC06_RS20930 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC06_RS20935 ENOG4105KRI phosphocarrier protein (HPr FOC06_RS20945 ENOG4105CHW UPF0052 protein FOC06_RS20955 ENOG4108Z4K mutator MutT protein FOC06_RS20965 ENOG4105C3M thioredoxin reductase FOC06_RS20975 ENOG4108S4C acetyltransferase FOC06_RS20995 ENOG41086DT Membrane protein of unknown function FOC06_RS21005 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC06_RS21010 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC06_RS21015 ENOG4105D7V transposase FOC06_RS21030 ENOG4107TXC Transcriptional regulator FOC06_RS21055 ENOG4105HMI Membrane FOC06_RS21060 ENOG4105DUM transcriptional regulator, lysR family FOC06_RS21070 ENOG4108WS4 fmn reductase FOC06_RS21085 ENOG4105BZ1 (ABC) transporter FOC06_RS21095 ENOG4105CN1 protease FOC06_RS21100 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC06_RS21105 ENOG4105CAK Cell division ATP-binding protein ftsE FOC06_RS21125 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC06_RS21130 ENOG4105MS2 ribosomal subunit Interface protein FOC06_RS21135 ENOG4105VEQ Cold shock protein FOC06_RS21140 ENOG41081UC Inherit from COG: Competence protein FOC06_RS21155 ENOG4105KVH Transcriptional regulator FOC06_RS21165 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC06_RS21170 ENOG4108KGH TRANSCRIPTIONal FOC06_RS21175 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC06_RS21180 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC06_RS21185 ENOG4105ESV Glycosyl transferase, family 4 FOC06_RS21195 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC06_RS21210 ENOG410901P UPF0249 protein FOC06_RS21215 ENOG4105F8D glycoside hydrolase family 4 FOC06_RS21220 ENOG4105VCP PTS System FOC06_RS21225 ENOG4105CK1 PTS System FOC06_RS21235 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC06_RS21240 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC06_RS21245 ENOG4105VCP PTS System FOC06_RS21255 ENOG4105VZJ PTS System FOC06_RS21270 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOC06_RS21275 ENOG4105ECB domain protein FOC06_RS21280 ENOG4107RSM transcriptional regulator FOC06_RS21320 ENOG4105DAA L-lactate FOC06_RS21330 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC06_RS21340 ENOG4105E0M Sulfatase FOC06_RS21370 ENOG4105C94 Transporter FOC06_RS21375 ENOG41069ER domain protein FOC06_RS21400 ENOG4105KBK Zinc finger, swim domain protein FOC06_RS21405 ENOG4105C0D helicase FOC06_RS21435 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC06_RS21445 ENOG4107RBB ABC transporter, permease FOC06_RS21450 ENOG4105C19 ABC transporter FOC06_RS21470 ENOG4105CXY transporter FOC06_RS21485 ENOG4105BZU Histidine kinase FOC06_RS21490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_RS21495 ENOG4105CMR udp-glucose 4-epimerase FOC06_RS21510 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC06_RS21515 ENOG4105EY8 ABC transporter FOC06_RS21570 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC06_RS21585 ENOG4105FRN stage II sporulation protein FOC06_RS21620 ENOG4106778 Protein of unknown function (DUF1146) FOC06_RS21625 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC06_RS21630 ENOG4105C8S subunit m FOC06_RS21635 ENOG4105D65 subunit l FOC06_RS21660 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC06_RS21665 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC06_RS21675 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC06_RS21680 ENOG4105BZU Histidine kinase FOC06_RS21730 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC06_RS21735 ENOG41062M3 atp synthase FOC06_RS21765 ENOG4108YZG isomerase FOC06_RS21780 ENOG4108VGI doxx family FOC06_RS21785 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC06_RS21800 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC06_RS21810 ENOG4108ZXQ stage ii sporulation protein r FOC06_RS21815 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC06_RS21820 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC06_RS21835 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC06_RS21840 ENOG4105CBT Fructose-1,6-bisphosphatase FOC06_RS21845 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC06_RS21880 ENOG4105C1G acyl-Coa dehydrogenase FOC06_RS21885 ENOG4105C1G acyl-Coa dehydrogenase FOC06_RS21890 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC06_RS21900 ENOG4105DF6 Fe-S oxidoreductase FOC06_RS21915 ENOG4105BZU Histidine kinase FOC06_RS21940 ENOG4105BZU Histidine kinase FOC06_RS21945 ENOG4105KCT ABC transporter FOC06_RS21950 ENOG4108M15 ABC transporter FOC06_RS21955 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC06_RS21965 ENOG4105IIU Aminopeptidase FOC06_RS21985 ENOG4105EMN RNA polymerase sigma factor FOC06_RS21995 ENOG410684U Domain of unknown function (DUF1934) FOC06_RS22015 ENOG4105CYW agmatinase FOC06_RS22025 ENOG4105DXB Major Facilitator superfamily FOC06_RS22030 ENOG4107SWG transcriptional regulator MERR family FOC06_RS22035 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC06_RS22040 ENOG4105BZ4 penicillin-binding protein FOC06_RS22045 ENOG4108XFG YwhD family FOC06_RS22050 ENOG4108Z4T Peptidase M50 FOC06_RS22055 ENOG41069HH 4-oxalocrotonate tautomerase FOC06_RS22060 ENOG4105DCI Phosphohydrolase FOC06_RS22065 ENOG4108MES Periplasmic binding protein FOC06_RS22070 ENOG4105E0A ABC, transporter FOC06_RS22075 ENOG4105EHG Permease protein FOC06_RS22090 ENOG4108VCI transcription factor, rsfa family FOC06_RS22105 ENOG4108IJ2 phosphate acetyltransferase FOC06_RS22120 ENOG4108VKI Cell wall hydrolase FOC06_RS22150 ENOG410667J hydrolase FOC06_RS22155 ENOG4105VCH membrane FOC06_RS22165 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC06_RS22170 ENOG4105CJ1 ABC, transporter FOC06_RS22175 ENOG41090WU lipolytic protein G-D-S-L family FOC06_RS22190 ENOG4105D6E homoserine dehydrogenase FOC06_RS22215 ENOG4108Y4K DNA-binding transcriptional activator FOC06_RS22225 ENOG4105WH1 Two component transcriptional regulator luxr family FOC06_RS22235 ENOG4105DWF phosphomethylpyrimidine kinase FOC06_RS22240 ENOG4105BZU Histidine kinase FOC06_RS22245 ENOG4105VCD cytoplasmic protein FOC06_RS22250 ENOG4105D22 carbon starvation protein FOC06_RS22255 ENOG4105DY9 regulatoR FOC06_RS22260 ENOG41079KZ Major Facilitator Superfamily FOC06_RS22280 ENOG4105EN6 Membrane FOC06_RS22285 ENOG4106YBV Methyl-accepting chemotaxis FOC06_RS22295 ENOG4108S4H thioesterase Superfamily protein FOC06_RS22305 ENOG4105JEU Glycosyl transferase, family 2 FOC06_RS22310 ENOG4105C5H ABC transporter FOC06_RS22330 ENOG4105CKK Glycosyl transferase, family 2 FOC06_RS22335 ENOG41067SE Tetr family transcriptional regulator FOC06_RS22345 ENOG4105E0X reductase FOC06_RS22350 ENOG4106F5Q Membrane FOC06_RS22365 ENOG4105DY9 regulatoR FOC06_RS22370 ENOG4108HRK Histidine kinase FOC06_RS22375 ENOG4107RGD Major Facilitator superfamily FOC06_RS22390 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC06_RS22400 ENOG4105IW1 AmiS UreI transporter FOC06_RS22410 ENOG4105CMR udp-glucose 4-epimerase FOC06_RS22415 ENOG4108UT2 hemolysin iii FOC06_RS22440 ENOG4105DPN Oligoendopeptidase f FOC06_RS22460 ENOG4105C0H protease FOC06_RS22465 ENOG4105Q2H domain protein FOC06_RS22480 ENOG4105BZU Histidine kinase FOC06_RS22485 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_RS22515 ENOG4105CDU Replicative dna helicase FOC06_RS22525 ENOG4105BZR domain protein FOC06_RS22530 ENOG4108XMW Membrane FOC06_RS22540 ENOG4108UUM single-stranded DNA-binding protein FOC06_RS22550 ENOG4105C3G gtp-binding protein FOC06_RS22555 ENOG4105VDK protein, conserved in bacteria FOC06_RS22560 ENOG4105D8X mechanosensitive ion channel FOC06_RS22565 ENOG4108ZDA Sporulation protein YyaC FOC06_RS22570 ENOG4105FA0 parb-like partition protein FOC06_RS22575 ENOG4107QJE Chromosome Partitioning Protein FOC06_RS22595 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC06_RS22605 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC06_RS22625 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC06_RS22630 ENOG410848D S4 domain protein YaaA FOC06_RS22645 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC06_RS22680 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC06_RS22715 ENOG4105ZMH deoxynucleoside kinase FOC06_RS22725 ENOG4105GTG Isochorismatase FOC06_RS22730 ENOG4108Z6B deaminase FOC06_RS22740 ENOG4105C6E dna polymerase iii FOC06_RS22760 ENOG41067KS pro-sigma K processing FOC06_RS22795 ENOG4105CXN decarboxylase FOC06_RS22805 ENOG4105FA2 dna polymerase iii FOC06_RS22810 ENOG4105MA4 psp1 domain protein FOC06_RS22820 ENOG41060K3 Methyltransferase FOC06_RS22830 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC06_RS22835 ENOG4105KRN Transcriptional regulator, abrb family FOC06_RS22845 ENOG4105F8V Hydrolase, tatD family FOC06_RS22850 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC06_RS22860 ENOG4105XFA sporulation peptidase YabG FOC06_RS22865 ENOG4105W42 Veg protein FOC06_RS22880 ENOG4105DFT pur operon repressor FOC06_RS22885 ENOG4105KME endoribonuclease L-psp FOC06_RS22900 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC06_RS22905 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC06_RS22915 ENOG4108JA2 transcriptioN-repair coupling factor FOC06_RS22920 ENOG4108M14 stage v sporulation protein t FOC06_RS22930 ENOG4108IY2 MazG family FOC06_RS22935 ENOG41082I2 s4 domain protein FOC06_RS22940 ENOG4105VYY sporulation protein yabp FOC06_RS22955 ENOG41060GV RNA binding s1 domain protein FOC06_RS22975 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC06_RS22980 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC06_RS22985 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC06_RS23000 ENOG4105C6T cysteine synthase FOC06_RS23005 ENOG4105CRQ synthase (Component I) FOC06_RS23010 ENOG4105DDQ anthranilate synthase FOC06_RS23015 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC06_RS23020 ENOG4105EEI dihydropteroate synthase FOC06_RS23025 ENOG4105KRF dihydroneopterin aldolase FOC06_RS23030 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC06_RS23040 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC06_RS23070 ENOG4108Z0C Uvrb UvrC protein FOC06_RS23085 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC06_RS23095 ENOG4105CTP PilT protein domain protein FOC06_RS23115 ENOG4105D7W serine acetyltransferase FOC06_RS23130 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC06_RS23135 ENOG4105M0M Tetracycline resistance protein FOC06_RS23140 ENOG4105QIV RNA polymerase FOC06_RS23155 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC06_RS23180 ENOG4107Y49 methyltransferase FOC06_RS23190 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC06_RS23195 ENOG4105XPM ribosomal protein FOC06_RS23300 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOC06_RS23325 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC06_RS23335 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC06_RS23345 ENOG41067V7 50S ribosomal protein L36 FOC06_RS23375 ENOG4108JJB ABC transporter FOC06_RS23380 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC06_RS23385 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC06_RS23410 ENOG4105D1F ATP-binding protein FOC06_RS23425 ENOG4108NMV polysaccharide deacetylase FOC06_RS23505 ENOG4105C8B TIGR00159 family FOC06_RS23510 ENOG4107U5W ybbr family FOC06_RS23525 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC06_RS23530 ENOG4108VQT Alpha beta hydrolase fold protein FOC06_RS23550 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC06_RS23555 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC06_RS23590 ENOG4108UMI ABC transporter, permease FOC06_RS23595 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC06_RS23600 ENOG4105D01 (LipO)protein FOC06_RS23605 ENOG4105EE1 crotonyl-CoA reductase FOC06_RS23615 ENOG4105IQ5 FAD linked oxidase domain protein FOC06_RS23630 ENOG4105C2C drug resistance transporter, Bcr CflA FOC06_RS23645 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC06_RS23650 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC06_RS23655 ENOG4105C3U ABC transporter FOC06_RS23660 ENOG4108JQ7 (ABC) transporter FOC06_RS23690 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC06_RS23695 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC06_RS23705 ENOG4105II7 pyrroline-5-carboxylate reductase FOC06_RS23710 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC06_RS23720 ENOG4105E0C molybdate abc transporter FOC06_RS23730 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC06_RS23740 ENOG4105EGI Transcriptional regulator FOC06_RS23760 ENOG4105F6E Acyl-transferase FOC06_RS23780 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC06_RS23790 ENOG4108RE7 deoxyribonuclease FOC06_RS23795 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC06_RS23815 ENOG4105C5H ABC transporter FOC06_RS23830 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC06_RS23840 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC06_RS23845 ENOG4105C3U ABC transporter FOC06_RS23850 ENOG4108JQ7 (ABC) transporter FOC06_RS23870 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC06_RS23875 ENOG4105ERH Fumarylacetoacetate hydrolase FOC06_RS23885 ENOG4108SC4 )-transporter FOC06_RS23895 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC06_RS23910 ENOG4107ZXI Rhomboid family FOC06_RS23920 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC06_RS23925 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC06_RS23935 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC06_RS24035 ENOG4105K8N protein family UPF0079, ATPase FOC06_RS24040 ENOG41072GX Peptidase M22 Glycoprotease FOC06_RS24045 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC06_RS24050 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC06_RS24055 ENOG4105C5H ABC transporter FOC06_RS24070 ENOG4108TYN CAAX amino terminal protease family protein FOC06_RS24090 ENOG4105C7N Xanthine uracil vitamin C permease FOC06_RS24100 ENOG4105BZU Histidine kinase FOC06_RS24130 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC06_RS24170 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC06_RS24190 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC06_RS24210 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC06_RS24215 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC06_RS24220 ENOG4105C83 adenylosuccinate lyase FOC06_RS24230 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC06_RS24255 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC06_RS24265 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC06_RS24290 ENOG4105C4R Atp-dependent dna helicase FOC06_RS24315 ENOG4108W2Y isochorismatase FOC06_RS24320 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC06_RS24325 ENOG4108UMI ABC transporter, permease FOC06_RS24330 ENOG4105D01 (LipO)protein FOC06_RS24350 ENOG410834F Transcriptional regulator FOC06_RS24375 ENOG4105CBD Diacylglycerol kinase FOC06_RS24380 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC06_RS24385 ENOG4108JPW Aminotransferase FOC06_RS24395 ENOG4105C26 Dehydrogenase FOC06_RS24400 ENOG4105KPY Small multidrug resistance protein FOC06_RS24420 ENOG4105D9N nucleoside FOC06_RS24425 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC06_RS24440 ENOG4108W15 Protein of unknown function (DUF1456) FOC06_RS24455 ENOG4105DTQ mandelate racemase muconate lactonizing FOC06_RS24465 ENOG4105DFD Na H antiporter FOC06_RS24485 ENOG4105D3R alkyl hydroperoxide reductase FOC06_RS24490 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FOC06_RS24500 ENOG4107W7X Aldolase FOC06_RS24505 ENOG4105EHG Permease protein FOC06_RS24510 ENOG4105DQ5 transport system permease protein FOC06_RS24515 ENOG4108V5C ABC transporter FOC06_RS24535 ENOG4106UIA FOC06_RS24540 ENOG4106UIA FOC06_RS24565 ENOG4105BZU Histidine kinase FOC06_RS24585 ENOG410756H nucleotidyltransferase FOC06_RS24590 ENOG4105D2S major facilitator superfamily FOC06_RS24605 ENOG4105E5Q amino acid AbC transporter FOC06_RS24610 ENOG4105EAB amino acid AbC transporter FOC06_RS24620 ENOG4105C8Q Methyl-accepting chemotaxis FOC06_RS24625 ENOG4105C8Q Methyl-accepting chemotaxis FOC06_RS24635 ENOG4105CI1 PTS System FOC06_RS24665 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC06_RS24680 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC06_RS24695 ENOG4105C5H ABC transporter FOC06_RS24720 ENOG41062JF Transcriptional regulator FOC06_RS24740 ENOG4105DEU major facilitator superfamily FOC06_RS24755 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) FOC06_RS24770 ENOG4108N0M stress protein FOC06_RS24775 ENOG4106FN3 tellurium resistance protein FOC06_RS24780 ENOG4106FN3 tellurium resistance protein FOC06_RS24785 ENOG4107TS3 membrane protein, TerC FOC06_RS24790 ENOG4108TTB tellurium resistance protein FOC06_RS24810 ENOG4105KJF protein tyrosine phosphatase FOC06_RS24820 ENOG4107U9T Pfam:Ribonuclease_BN FOC06_RS24825 ENOG4105C59 p-type ATPase FOC06_RS24830 ENOG4108IPJ Membrane FOC06_RS24850 ENOG4107ZTW SNARE associated Golgi FOC06_RS24865 ENOG410606W general stress protein FOC06_RS24870 ENOG4105UPD Calcium Proton FOC06_RS24910 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC06_RS24915 ENOG4105VTR Integrase FOC06_RS24920 ENOG4108IMY Transcriptional regulator FOC06_RS25180 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC06_RS25190 ENOG4108JUB Transcriptional regulator FOC06_RS25200 ENOG4108IQI permease FOC06_RS25225 ENOG4105CSV Glutaminase FOC06_RS25235 ENOG4108A04 Beta-lactamase FOC06_RS25250 ENOG4105CKK Glycosyl transferase, family 2 FOC06_RS25260 ENOG4107QQG Dehydrogenase FOC06_RS25265 ENOG4105C3I Nad-dependent epimerase dehydratase FOC06_RS25285 ENOG4105F1A Pyruvate formate-lyase FOC06_RS25305 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC06_RS25310 ENOG4105ECP epimerase FOC06_RS25340 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC06_RS25345 ENOG4105CEN a g-specific adenine glycosylase FOC06_RS25350 ENOG4106BXE FOC06_RS25370 ENOG4105BZ1 (ABC) transporter FOC06_RS25375 ENOG4107NBY Membrane FOC06_RS25380 ENOG4105CBC glutamate synthase FOC06_RS25390 ENOG4108IUW ABC transporter FOC06_RS25410 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC06_RS25415 ENOG4105G5W regulator Fur family FOC06_RS25530 ENOG4108JQC penicillin-binding protein 1A FOC06_RS25535 ENOG4107ZQN disulfide bond FOC06_RS25545 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC06_RS25555 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC06_RS25560 ENOG4105BZU Histidine kinase FOC06_RS25565 ENOG4105CYN Serine protein kinase FOC06_RS25585 ENOG4105C94 Transporter FOC06_RS25600 ENOG4105DZ6 Band 7 protein FOC06_RS25610 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC06_RS25620 ENOG4105D4T Citrate transporter FOC06_RS25640 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC06_RS25645 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC06_RS25650 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC06_RS25655 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC06_RS25660 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC06_RS25665 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC06_RS25670 ENOG4108STX response regulator FOC06_RS25675 ENOG4105US7 Histidine kinase FOC06_RS25700 ENOG4108MRH transcriptional regulatory protein FOC06_RS25710 ENOG4105C6K Malic enzyme FOC06_RS25720 ENOG4108UZ3 Transporter FOC06_RS25725 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC06_RS25735 ENOG4105BZU Histidine kinase FOC06_RS25740 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_RS25745 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC06_RS25750 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC06_RS25755 ENOG4108JB9 formate dehydrogenase FOC06_RS25775 ENOG4105CUB amino acid FOC06_RS25785 ENOG4105C59 p-type ATPase FOC06_RS25790 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC06_RS25825 ENOG41073R8 VanW family FOC06_RS25830 ENOG4108KGH TRANSCRIPTIONal FOC06_RS25835 ENOG4105D9N nucleoside FOC06_RS25840 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC06_RS25845 ENOG4105C37 (CBS) domain FOC06_RS25850 ENOG4108IJ0 Aspartate ammonia-lyase FOC06_RS25855 ENOG4105DAA L-lactate FOC06_RS25870 ENOG4105DUX Transporter FOC06_RS25875 ENOG4108MES Periplasmic binding protein FOC06_RS25880 ENOG4105DQ5 transport system permease protein FOC06_RS25885 ENOG4108IHU transport system permease protein FOC06_RS25890 ENOG4105E0A ABC, transporter FOC06_RS25895 ENOG4105DMQ Methyltransferase FOC06_RS25905 ENOG4105EXW epimerase dehydratase FOC06_RS25915 ENOG4107T89 von Willebrand factor, type A FOC06_RS25920 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC06_RS25925 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC06_RS25940 ENOG4105BZU Histidine kinase FOC06_RS25945 ENOG4105D5Q Arginine ornithine antiporter FOC06_RS25950 ENOG4107414 GntR family transcriptional regulator FOC06_RS25955 ENOG4105C5Y PTS System FOC06_RS25960 ENOG4105CG3 alpha amylase, catalytic region FOC06_RS25975 ENOG4105E1K spore germination protein FOC06_RS25985 ENOG4105CRN Aminoglycoside phosphotransferase FOC06_RS25990 ENOG4105BZG amino acid carrier protein FOC06_RS25995 ENOG4105CDA abc transporter atp-binding protein FOC06_RS26000 ENOG4105CT1 (ABC) transporter FOC06_RS26005 ENOG4105EAD ABC transporter FOC06_RS26010 ENOG4105DRP amino acid AbC transporter FOC06_RS26015 ENOG4108IQI permease FOC06_RS26040 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC06_RS26045 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC06_RS26050 ENOG4105BZU Histidine kinase FOC06_RS26065 ENOG4105CHH sulfate transporter FOC06_RS26070 ENOG41068KF Universal stress protein FOC06_RS26080 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC06_RS26090 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC06_RS26095 ENOG4108JQ7 (ABC) transporter FOC06_RS26105 ENOG4105CXY transporter FOC06_RS26110 ENOG41067TZ transcriptional regulator, MarR family FOC06_RS26120 ENOG4105ETE Transcriptional regulator (LacI family FOC06_RS26125 ENOG4108RVA ribokinase FOC06_RS26140 ENOG4105CNN ABC, transporter FOC06_RS26145 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC06_RS26150 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC06_RS26210 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC06_RS26215 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC06_RS26220 ENOG41069ER domain protein FOC06_RS26225 ENOG4105VZ8 Transcriptional regulator FOC06_RS26230 ENOG4107D63 FOC06_RS26240 ENOG4105DUX Transporter FOC06_RS26260 ENOG4105C85 amino acid FOC06_RS26265 ENOG4105C7N Xanthine uracil vitamin C permease FOC06_RS26305 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC06_RS26310 ENOG4105E2S oxidase) subunit II FOC06_RS26315 ENOG4108IQI permease FOC06_RS26330 ENOG4106CAD Protein of unknown function (DUF3311) FOC06_RS26335 ENOG4105E1V na solute symporter FOC06_RS26350 ENOG4108NHD germination protein FOC06_RS26355 ENOG4105CE1 Ferrous iron transport protein b FOC06_RS26360 ENOG4105CE1 Ferrous iron transport protein b FOC06_RS26365 ENOG4105CE1 Ferrous iron transport protein b FOC06_RS26370 ENOG4105CVA phosphate FOC06_RS26375 ENOG4105C8U phosphate abc transporter FOC06_RS26380 ENOG4105E2Z phosphate ABC transporter (Permease FOC06_RS26505 ENOG41080XQ Signal transduction protein with cbs domains FOC06_RS26525 ENOG4105ETU transcriptional activator (TenA FOC06_RS26535 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC06_RS26545 ENOG4108VEU Thiamine monophosphate synthase FOC06_RS26550 ENOG41080HI glycine oxidase FOC06_RS26565 ENOG4105D06 uba thif-type nad fad binding protein FOC06_RS26570 ENOG4105DWF phosphomethylpyrimidine kinase FOC06_RS26620 ENOG4108INS Transcriptional regulator FOC06_RS26635 ENOG4105C7N Xanthine uracil vitamin C permease FOC06_RS26665 ENOG4105C5Y PTS System FOC06_RS26720 ENOG4107Y03 Nitroreductase FOC06_RS26725 ENOG4105ED1 spovr family FOC06_RS26750 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC06_RS26755 ENOG4105XTG Pfam:DUF156 FOC06_RS26760 ENOG4105VFE sira family FOC06_RS26765 ENOG4107TPS domain protein FOC06_RS26770 ENOG4105VFE sira family FOC06_RS26775 ENOG41085GJ domain protein FOC06_RS26785 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC06_RS26790 ENOG41087NI Sulfite exporter TauE/SafE FOC06_RS26800 ENOG4108KGH TRANSCRIPTIONal FOC06_RS26825 ENOG4105EMD TRANSCRIPTIONal FOC06_RS26830 ENOG4105VCP PTS System FOC06_RS26835 ENOG4105VZJ PTS System FOC06_RS26855 ENOG41069ER domain protein FOC06_RS26860 ENOG4107RBB ABC transporter, permease FOC06_RS26865 ENOG4105C19 ABC transporter FOC06_RS26895 ENOG4105WEF catalase FOC06_RS26930 ENOG4107T5V SNARE associated Golgi FOC06_RS26960 ENOG4105CUB amino acid FOC06_RS26965 ENOG4107RWR Sodium hydrogen exchanger FOC06_RS26975 ENOG4106KNT transcriptional regulator FOC06_RS27010 ENOG4108PCN EamA-like transporter family FOC06_RS27015 ENOG4108YXU transcriptional regulator AsnC family FOC06_RS27040 ENOG4105NF4 modulator of drug activity FOC06_RS27045 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC06_RS27050 ENOG4105E5W Transporter