locus-tag class description FOC08_RS00020 ENOG4105EFC phage portal protein HK97 family FOC08_RS00045 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC08_RS00055 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC08_RS00060 ENOG4105CP7 Triose-phosphate isomerase FOC08_RS00085 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC08_RS00105 ENOG41090VF Stage v sporulation protein ac FOC08_RS00110 ENOG4105CZ3 stage V sporulation protein ad FOC08_RS00125 ENOG4105H67 Protein of unknown function (DUF421) FOC08_RS00130 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC08_RS00135 ENOG4105KRI phosphocarrier protein (HPr FOC08_RS00145 ENOG4105CHW UPF0052 protein FOC08_RS00155 ENOG4108Z4K mutator MutT protein FOC08_RS00165 ENOG4105C3M thioredoxin reductase FOC08_RS00175 ENOG4108S4C acetyltransferase FOC08_RS00195 ENOG41086DT Membrane protein of unknown function FOC08_RS00205 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC08_RS00210 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC08_RS00215 ENOG4105D7V transposase FOC08_RS00230 ENOG4107TXC Transcriptional regulator FOC08_RS00255 ENOG4105HMI Membrane FOC08_RS00260 ENOG4105DUM transcriptional regulator, lysR family FOC08_RS00270 ENOG4108WS4 fmn reductase FOC08_RS00285 ENOG4105BZ1 (ABC) transporter FOC08_RS00295 ENOG4105CN1 protease FOC08_RS00300 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC08_RS00305 ENOG4105CAK Cell division ATP-binding protein ftsE FOC08_RS00325 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC08_RS00330 ENOG4105MS2 ribosomal subunit Interface protein FOC08_RS00335 ENOG4105VEQ Cold shock protein FOC08_RS00340 ENOG41081UC Inherit from COG: Competence protein FOC08_RS00355 ENOG4105KVH Transcriptional regulator FOC08_RS00365 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC08_RS00370 ENOG4108KGH TRANSCRIPTIONal FOC08_RS00375 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC08_RS00380 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC08_RS00385 ENOG4105ESV Glycosyl transferase, family 4 FOC08_RS00395 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC08_RS00410 ENOG410901P UPF0249 protein FOC08_RS00415 ENOG4105F8D glycoside hydrolase family 4 FOC08_RS00420 ENOG4105VCP PTS System FOC08_RS00425 ENOG4105CK1 PTS System FOC08_RS00435 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC08_RS00440 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC08_RS00445 ENOG4105VCP PTS System FOC08_RS00455 ENOG4105VZJ PTS System FOC08_RS00470 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOC08_RS00475 ENOG4105ECB domain protein FOC08_RS00480 ENOG4107RSM transcriptional regulator FOC08_RS00520 ENOG4105DAA L-lactate FOC08_RS00530 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC08_RS00540 ENOG4105E0M Sulfatase FOC08_RS00570 ENOG4105C94 Transporter FOC08_RS00575 ENOG41069ER domain protein FOC08_RS00600 ENOG4105KBK Zinc finger, swim domain protein FOC08_RS00605 ENOG4105C0D helicase FOC08_RS00635 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC08_RS00645 ENOG4107RBB ABC transporter, permease FOC08_RS00650 ENOG4105C19 ABC transporter FOC08_RS00670 ENOG4105CXY transporter FOC08_RS00685 ENOG4105BZU Histidine kinase FOC08_RS00690 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC08_RS00695 ENOG4105CMR udp-glucose 4-epimerase FOC08_RS00710 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC08_RS00715 ENOG4105EY8 ABC transporter FOC08_RS00770 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC08_RS00785 ENOG4105FRN stage II sporulation protein FOC08_RS00820 ENOG4106778 Protein of unknown function (DUF1146) FOC08_RS00825 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC08_RS00830 ENOG4105C8S subunit m FOC08_RS00835 ENOG4105D65 subunit l FOC08_RS00860 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC08_RS00865 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC08_RS00875 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC08_RS00880 ENOG4105BZU Histidine kinase FOC08_RS00930 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC08_RS00935 ENOG41062M3 atp synthase FOC08_RS00965 ENOG4108YZG isomerase FOC08_RS00980 ENOG4108VGI doxx family FOC08_RS00985 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC08_RS01000 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC08_RS01010 ENOG4108ZXQ stage ii sporulation protein r FOC08_RS01015 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC08_RS01020 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC08_RS01035 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC08_RS01040 ENOG4105CBT Fructose-1,6-bisphosphatase FOC08_RS01045 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC08_RS01080 ENOG4105C1G acyl-Coa dehydrogenase FOC08_RS01085 ENOG4105C1G acyl-Coa dehydrogenase FOC08_RS01090 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC08_RS01100 ENOG4105DF6 Fe-S oxidoreductase FOC08_RS01115 ENOG4105BZU Histidine kinase FOC08_RS01140 ENOG4105BZU Histidine kinase FOC08_RS01145 ENOG4105KCT ABC transporter FOC08_RS01150 ENOG4108M15 ABC transporter FOC08_RS01155 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC08_RS01165 ENOG4105IIU Aminopeptidase FOC08_RS01185 ENOG4105EMN RNA polymerase sigma factor FOC08_RS01195 ENOG410684U Domain of unknown function (DUF1934) FOC08_RS01215 ENOG4105CYW agmatinase FOC08_RS01225 ENOG4105DXB Major Facilitator superfamily FOC08_RS01230 ENOG4107SWG transcriptional regulator MERR family FOC08_RS01235 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC08_RS01240 ENOG4105BZ4 penicillin-binding protein FOC08_RS01245 ENOG4108XFG YwhD family FOC08_RS01250 ENOG4108Z4T Peptidase M50 FOC08_RS01255 ENOG41069HH 4-oxalocrotonate tautomerase FOC08_RS01260 ENOG4105DCI Phosphohydrolase FOC08_RS01265 ENOG4108MES Periplasmic binding protein FOC08_RS01270 ENOG4105E0A ABC, transporter FOC08_RS01275 ENOG4105EHG Permease protein FOC08_RS01290 ENOG4108VCI transcription factor, rsfa family FOC08_RS01305 ENOG4108IJ2 phosphate acetyltransferase FOC08_RS01320 ENOG4108VKI Cell wall hydrolase FOC08_RS01350 ENOG410667J hydrolase FOC08_RS01355 ENOG4105VCH membrane FOC08_RS01365 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC08_RS01370 ENOG4105CJ1 ABC, transporter FOC08_RS01375 ENOG41090WU lipolytic protein G-D-S-L family FOC08_RS01390 ENOG4105D6E homoserine dehydrogenase FOC08_RS01415 ENOG4108Y4K DNA-binding transcriptional activator FOC08_RS01425 ENOG4105WH1 Two component transcriptional regulator luxr family FOC08_RS01435 ENOG4105DWF phosphomethylpyrimidine kinase FOC08_RS01440 ENOG4105BZU Histidine kinase FOC08_RS01445 ENOG4105VCD cytoplasmic protein FOC08_RS01450 ENOG4105D22 carbon starvation protein FOC08_RS01455 ENOG4105DY9 regulatoR FOC08_RS01460 ENOG41079KZ Major Facilitator Superfamily FOC08_RS01480 ENOG4105EN6 Membrane FOC08_RS01485 ENOG4106YBV Methyl-accepting chemotaxis FOC08_RS01495 ENOG4108S4H thioesterase Superfamily protein FOC08_RS01505 ENOG4105JEU Glycosyl transferase, family 2 FOC08_RS01510 ENOG4105C5H ABC transporter FOC08_RS01530 ENOG4105CKK Glycosyl transferase, family 2 FOC08_RS01535 ENOG41067SE Tetr family transcriptional regulator FOC08_RS01545 ENOG4105E0X reductase FOC08_RS01550 ENOG4106F5Q Membrane FOC08_RS01565 ENOG4105DY9 regulatoR FOC08_RS01570 ENOG4108HRK Histidine kinase FOC08_RS01575 ENOG4107RGD Major Facilitator superfamily FOC08_RS01590 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC08_RS01600 ENOG4105IW1 AmiS UreI transporter FOC08_RS01610 ENOG4105CMR udp-glucose 4-epimerase FOC08_RS01615 ENOG4108UT2 hemolysin iii FOC08_RS01625 ENOG4105C1J atp-dependent rna helicase FOC08_RS01640 ENOG4105DPN Oligoendopeptidase f FOC08_RS01660 ENOG4105C0H protease FOC08_RS01665 ENOG4105Q2H domain protein FOC08_RS01680 ENOG4105BZU Histidine kinase FOC08_RS01685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC08_RS01715 ENOG4105CDU Replicative dna helicase FOC08_RS01725 ENOG4105BZR domain protein FOC08_RS01730 ENOG4108XMW Membrane FOC08_RS01740 ENOG4108UUM single-stranded DNA-binding protein FOC08_RS01750 ENOG4105C3G gtp-binding protein FOC08_RS01755 ENOG4105VDK protein, conserved in bacteria FOC08_RS01760 ENOG4105D8X mechanosensitive ion channel FOC08_RS01765 ENOG4108ZDA Sporulation protein YyaC FOC08_RS01770 ENOG4105FA0 parb-like partition protein FOC08_RS01775 ENOG4107QJE Chromosome Partitioning Protein FOC08_RS01795 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC08_RS01805 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC08_RS01825 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC08_RS01830 ENOG410848D S4 domain protein YaaA FOC08_RS01845 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC08_RS01880 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC08_RS01915 ENOG4105ZMH deoxynucleoside kinase FOC08_RS01925 ENOG4105GTG Isochorismatase FOC08_RS01930 ENOG4108Z6B deaminase FOC08_RS01940 ENOG4105C6E dna polymerase iii FOC08_RS01960 ENOG41067KS pro-sigma K processing FOC08_RS01995 ENOG4105CXN decarboxylase FOC08_RS02005 ENOG4105FA2 dna polymerase iii FOC08_RS02010 ENOG4105MA4 psp1 domain protein FOC08_RS02020 ENOG41060K3 Methyltransferase FOC08_RS02030 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC08_RS02035 ENOG4105KRN Transcriptional regulator, abrb family FOC08_RS02045 ENOG4105F8V Hydrolase, tatD family FOC08_RS02050 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC08_RS02060 ENOG4105XFA sporulation peptidase YabG FOC08_RS02065 ENOG4105W42 Veg protein FOC08_RS02080 ENOG4105DFT pur operon repressor FOC08_RS02085 ENOG4105KME endoribonuclease L-psp FOC08_RS02100 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC08_RS02105 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC08_RS02115 ENOG4108JA2 transcriptioN-repair coupling factor FOC08_RS02120 ENOG4108M14 stage v sporulation protein t FOC08_RS02130 ENOG4108IY2 MazG family FOC08_RS02135 ENOG41082I2 s4 domain protein FOC08_RS02140 ENOG4105VYY sporulation protein yabp FOC08_RS02155 ENOG41060GV RNA binding s1 domain protein FOC08_RS02175 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC08_RS02180 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC08_RS02185 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC08_RS02200 ENOG4105C6T cysteine synthase FOC08_RS02205 ENOG4105CRQ synthase (Component I) FOC08_RS02210 ENOG4105DDQ anthranilate synthase FOC08_RS02215 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC08_RS02220 ENOG4105EEI dihydropteroate synthase FOC08_RS02225 ENOG4105KRF dihydroneopterin aldolase FOC08_RS02230 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC08_RS02240 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC08_RS02270 ENOG4108Z0C Uvrb UvrC protein FOC08_RS02285 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC08_RS02295 ENOG4105CTP PilT protein domain protein FOC08_RS02315 ENOG4105D7W serine acetyltransferase FOC08_RS02330 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC08_RS02335 ENOG4105M0M Tetracycline resistance protein FOC08_RS02340 ENOG4105QIV RNA polymerase FOC08_RS02355 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC08_RS02380 ENOG4107Y49 methyltransferase FOC08_RS02390 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC08_RS02395 ENOG4105XPM ribosomal protein FOC08_RS02500 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOC08_RS02525 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC08_RS02535 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC08_RS02545 ENOG41067V7 50S ribosomal protein L36 FOC08_RS02575 ENOG4108JJB ABC transporter FOC08_RS02580 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC08_RS02585 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC08_RS02610 ENOG4105D1F ATP-binding protein FOC08_RS02625 ENOG4108NMV polysaccharide deacetylase FOC08_RS02705 ENOG4105C8B TIGR00159 family FOC08_RS02710 ENOG4107U5W ybbr family FOC08_RS02725 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC08_RS02730 ENOG4108VQT Alpha beta hydrolase fold protein FOC08_RS02750 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC08_RS02755 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC08_RS02790 ENOG4108UMI ABC transporter, permease FOC08_RS02795 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC08_RS02800 ENOG4105D01 (LipO)protein FOC08_RS02805 ENOG4105EE1 crotonyl-CoA reductase FOC08_RS02815 ENOG4105IQ5 FAD linked oxidase domain protein FOC08_RS02830 ENOG4105C2C drug resistance transporter, Bcr CflA FOC08_RS02845 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC08_RS02850 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC08_RS02855 ENOG4105C3U ABC transporter FOC08_RS02860 ENOG4108JQ7 (ABC) transporter FOC08_RS02890 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC08_RS02895 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC08_RS02905 ENOG4105II7 pyrroline-5-carboxylate reductase FOC08_RS02910 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC08_RS02920 ENOG4105E0C molybdate abc transporter FOC08_RS02930 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC08_RS02940 ENOG4105EGI Transcriptional regulator FOC08_RS02960 ENOG4105F6E Acyl-transferase FOC08_RS02980 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC08_RS02990 ENOG4108RE7 deoxyribonuclease FOC08_RS02995 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC08_RS03015 ENOG4105C5H ABC transporter FOC08_RS03030 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC08_RS03040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC08_RS03045 ENOG4105C3U ABC transporter FOC08_RS03050 ENOG4108JQ7 (ABC) transporter FOC08_RS03070 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC08_RS03075 ENOG4105ERH Fumarylacetoacetate hydrolase FOC08_RS03085 ENOG4108SC4 )-transporter FOC08_RS03095 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC08_RS03110 ENOG4107ZXI Rhomboid family FOC08_RS03120 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC08_RS03125 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC08_RS03135 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC08_RS03235 ENOG4105K8N protein family UPF0079, ATPase FOC08_RS03240 ENOG41072GX Peptidase M22 Glycoprotease FOC08_RS03245 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC08_RS03250 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC08_RS03255 ENOG4105C5H ABC transporter FOC08_RS03270 ENOG4108TYN CAAX amino terminal protease family protein FOC08_RS03290 ENOG4105C7N Xanthine uracil vitamin C permease FOC08_RS03300 ENOG4105BZU Histidine kinase FOC08_RS03330 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC08_RS03370 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC08_RS03390 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC08_RS03410 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC08_RS03415 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC08_RS03420 ENOG4105C83 adenylosuccinate lyase FOC08_RS03430 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC08_RS03455 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC08_RS03465 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC08_RS03490 ENOG4105C4R Atp-dependent dna helicase FOC08_RS03515 ENOG4108W2Y isochorismatase FOC08_RS03520 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC08_RS03525 ENOG4108UMI ABC transporter, permease FOC08_RS03530 ENOG4105D01 (LipO)protein FOC08_RS03550 ENOG410834F Transcriptional regulator FOC08_RS03575 ENOG4105CBD Diacylglycerol kinase FOC08_RS03580 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC08_RS03585 ENOG4108JPW Aminotransferase FOC08_RS03595 ENOG4105C26 Dehydrogenase FOC08_RS03600 ENOG4105KPY Small multidrug resistance protein FOC08_RS03620 ENOG4105D9N nucleoside FOC08_RS03625 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC08_RS03640 ENOG4108W15 Protein of unknown function (DUF1456) FOC08_RS03655 ENOG4105DTQ mandelate racemase muconate lactonizing FOC08_RS03665 ENOG4105DFD Na H antiporter FOC08_RS03685 ENOG4105D3R alkyl hydroperoxide reductase FOC08_RS03690 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FOC08_RS03700 ENOG4107W7X Aldolase FOC08_RS03705 ENOG4105EHG Permease protein FOC08_RS03710 ENOG4105DQ5 transport system permease protein FOC08_RS03715 ENOG4108V5C ABC transporter FOC08_RS03735 ENOG4106UIA FOC08_RS03740 ENOG4106UIA FOC08_RS03765 ENOG4105BZU Histidine kinase FOC08_RS03785 ENOG410756H nucleotidyltransferase FOC08_RS03790 ENOG4105D2S major facilitator superfamily FOC08_RS03805 ENOG4105E5Q amino acid AbC transporter FOC08_RS03810 ENOG4105EAB amino acid AbC transporter FOC08_RS03820 ENOG4105C8Q Methyl-accepting chemotaxis FOC08_RS03825 ENOG4105C8Q Methyl-accepting chemotaxis FOC08_RS03835 ENOG4105CI1 PTS System FOC08_RS03865 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC08_RS03880 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC08_RS03895 ENOG4105C5H ABC transporter FOC08_RS03920 ENOG41062JF Transcriptional regulator FOC08_RS03940 ENOG4105DEU major facilitator superfamily FOC08_RS03955 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) FOC08_RS03970 ENOG4108N0M stress protein FOC08_RS03975 ENOG4106FN3 tellurium resistance protein FOC08_RS03980 ENOG4106FN3 tellurium resistance protein FOC08_RS03985 ENOG4107TS3 membrane protein, TerC FOC08_RS03990 ENOG4108TTB tellurium resistance protein FOC08_RS04010 ENOG4105KJF protein tyrosine phosphatase FOC08_RS04020 ENOG4107U9T Pfam:Ribonuclease_BN FOC08_RS04025 ENOG4105C59 p-type ATPase FOC08_RS04030 ENOG4108IPJ Membrane FOC08_RS04050 ENOG4107ZTW SNARE associated Golgi FOC08_RS04065 ENOG410606W general stress protein FOC08_RS04070 ENOG4105UPD Calcium Proton FOC08_RS04110 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC08_RS04115 ENOG4105VTR Integrase FOC08_RS04120 ENOG4108IMY Transcriptional regulator FOC08_RS04380 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC08_RS04390 ENOG4108JUB Transcriptional regulator FOC08_RS04400 ENOG4108IQI permease FOC08_RS04425 ENOG4105CSV Glutaminase FOC08_RS04435 ENOG4108A04 Beta-lactamase FOC08_RS04450 ENOG4105CKK Glycosyl transferase, family 2 FOC08_RS04460 ENOG4107QQG Dehydrogenase FOC08_RS04465 ENOG4105C3I Nad-dependent epimerase dehydratase FOC08_RS04485 ENOG4105F1A Pyruvate formate-lyase FOC08_RS04505 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC08_RS04510 ENOG4105ECP epimerase FOC08_RS04540 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC08_RS04545 ENOG4105CEN a g-specific adenine glycosylase FOC08_RS04550 ENOG4106BXE FOC08_RS04570 ENOG4105BZ1 (ABC) transporter FOC08_RS04575 ENOG4107NBY Membrane FOC08_RS04580 ENOG4105CBC glutamate synthase FOC08_RS04590 ENOG4108IUW ABC transporter FOC08_RS04610 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC08_RS04615 ENOG4105G5W regulator Fur family FOC08_RS04730 ENOG4108JQC penicillin-binding protein 1A FOC08_RS04735 ENOG4107ZQN disulfide bond FOC08_RS04745 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC08_RS04755 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC08_RS04760 ENOG4105BZU Histidine kinase FOC08_RS04765 ENOG4105CYN Serine protein kinase FOC08_RS04785 ENOG4105C94 Transporter FOC08_RS04800 ENOG4105DZ6 Band 7 protein FOC08_RS04810 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC08_RS04820 ENOG4105D4T Citrate transporter FOC08_RS04840 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC08_RS04845 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC08_RS04850 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC08_RS04855 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC08_RS04860 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC08_RS04865 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC08_RS04870 ENOG4108STX response regulator FOC08_RS04875 ENOG4105US7 Histidine kinase FOC08_RS04900 ENOG4108MRH transcriptional regulatory protein FOC08_RS04910 ENOG4105C6K Malic enzyme FOC08_RS04920 ENOG4108UZ3 Transporter FOC08_RS04925 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC08_RS04935 ENOG4105BZU Histidine kinase FOC08_RS04940 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC08_RS04945 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC08_RS04950 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC08_RS04955 ENOG4108JB9 formate dehydrogenase FOC08_RS04975 ENOG4105CUB amino acid FOC08_RS04985 ENOG4105C59 p-type ATPase FOC08_RS04990 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC08_RS05025 ENOG41073R8 VanW family FOC08_RS05030 ENOG4108KGH TRANSCRIPTIONal FOC08_RS05035 ENOG4105D9N nucleoside FOC08_RS05040 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC08_RS05045 ENOG4105C37 (CBS) domain FOC08_RS05050 ENOG4108IJ0 Aspartate ammonia-lyase FOC08_RS05055 ENOG4105DAA L-lactate FOC08_RS05070 ENOG4105DUX Transporter FOC08_RS05075 ENOG4108MES Periplasmic binding protein FOC08_RS05080 ENOG4105DQ5 transport system permease protein FOC08_RS05085 ENOG4108IHU transport system permease protein FOC08_RS05090 ENOG4105E0A ABC, transporter FOC08_RS05095 ENOG4105DMQ Methyltransferase FOC08_RS05105 ENOG4105EXW epimerase dehydratase FOC08_RS05115 ENOG4107T89 von Willebrand factor, type A FOC08_RS05120 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC08_RS05125 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC08_RS05140 ENOG4105BZU Histidine kinase FOC08_RS05145 ENOG4105D5Q Arginine ornithine antiporter FOC08_RS05150 ENOG4107414 GntR family transcriptional regulator FOC08_RS05155 ENOG4105C5Y PTS System FOC08_RS05160 ENOG4105CG3 alpha amylase, catalytic region FOC08_RS05175 ENOG4105E1K spore germination protein FOC08_RS05185 ENOG4105CRN Aminoglycoside phosphotransferase FOC08_RS05190 ENOG4105BZG amino acid carrier protein FOC08_RS05195 ENOG4105CDA abc transporter atp-binding protein FOC08_RS05200 ENOG4105CT1 (ABC) transporter FOC08_RS05205 ENOG4105EAD ABC transporter FOC08_RS05210 ENOG4105DRP amino acid AbC transporter FOC08_RS05215 ENOG4108IQI permease FOC08_RS05240 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC08_RS05245 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC08_RS05250 ENOG4105BZU Histidine kinase FOC08_RS05265 ENOG4105CHH sulfate transporter FOC08_RS05270 ENOG41068KF Universal stress protein FOC08_RS05280 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC08_RS05290 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC08_RS05295 ENOG4108JQ7 (ABC) transporter FOC08_RS05305 ENOG4105CXY transporter FOC08_RS05310 ENOG41067TZ transcriptional regulator, MarR family FOC08_RS05320 ENOG4105ETE Transcriptional regulator (LacI family FOC08_RS05325 ENOG4108RVA ribokinase FOC08_RS05335 ENOG4105C2J ABC transporter FOC08_RS05340 ENOG4105CNN ABC, transporter FOC08_RS05345 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC08_RS05350 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC08_RS05410 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC08_RS05415 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC08_RS05420 ENOG41069ER domain protein FOC08_RS05425 ENOG4105VZ8 Transcriptional regulator FOC08_RS05430 ENOG4107D63 FOC08_RS05440 ENOG4105DUX Transporter FOC08_RS05460 ENOG4105C85 amino acid FOC08_RS05465 ENOG4105C7N Xanthine uracil vitamin C permease FOC08_RS05505 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC08_RS05510 ENOG4105E2S oxidase) subunit II FOC08_RS05515 ENOG4108IQI permease FOC08_RS05530 ENOG4106CAD Protein of unknown function (DUF3311) FOC08_RS05535 ENOG4105E1V na solute symporter FOC08_RS05550 ENOG4108NHD germination protein FOC08_RS05555 ENOG4105CE1 Ferrous iron transport protein b FOC08_RS05560 ENOG4105CE1 Ferrous iron transport protein b FOC08_RS05565 ENOG4105CE1 Ferrous iron transport protein b FOC08_RS05570 ENOG4105CVA phosphate FOC08_RS05575 ENOG4105C8U phosphate abc transporter FOC08_RS05580 ENOG4105E2Z phosphate ABC transporter (Permease FOC08_RS05705 ENOG41080XQ Signal transduction protein with cbs domains FOC08_RS05725 ENOG4105ETU transcriptional activator (TenA FOC08_RS05735 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC08_RS05745 ENOG4108VEU Thiamine monophosphate synthase FOC08_RS05750 ENOG41080HI glycine oxidase FOC08_RS05765 ENOG4105D06 uba thif-type nad fad binding protein FOC08_RS05770 ENOG4105DWF phosphomethylpyrimidine kinase FOC08_RS05820 ENOG4108INS Transcriptional regulator FOC08_RS05835 ENOG4105C7N Xanthine uracil vitamin C permease FOC08_RS05865 ENOG4105C5Y PTS System FOC08_RS05920 ENOG4107Y03 Nitroreductase FOC08_RS05925 ENOG4105ED1 spovr family FOC08_RS05950 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC08_RS05955 ENOG4105XTG Pfam:DUF156 FOC08_RS05960 ENOG4105VFE sira family FOC08_RS05965 ENOG4107TPS domain protein FOC08_RS05970 ENOG4105VFE sira family FOC08_RS05975 ENOG41085GJ domain protein FOC08_RS05985 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC08_RS05990 ENOG41087NI Sulfite exporter TauE/SafE FOC08_RS06000 ENOG4108KGH TRANSCRIPTIONal FOC08_RS06025 ENOG4105EMD TRANSCRIPTIONal FOC08_RS06030 ENOG4105VCP PTS System FOC08_RS06035 ENOG4105VZJ PTS System FOC08_RS06055 ENOG41069ER domain protein FOC08_RS06060 ENOG4107RBB ABC transporter, permease FOC08_RS06065 ENOG4105C19 ABC transporter FOC08_RS06095 ENOG4105WEF catalase FOC08_RS06130 ENOG4107T5V SNARE associated Golgi FOC08_RS06160 ENOG4105CUB amino acid FOC08_RS06165 ENOG4107RWR Sodium hydrogen exchanger FOC08_RS06175 ENOG4106KNT transcriptional regulator FOC08_RS06210 ENOG4108PCN EamA-like transporter family FOC08_RS06215 ENOG4108YXU transcriptional regulator AsnC family FOC08_RS06225 ENOG4105KPY Small multidrug resistance protein FOC08_RS06230 ENOG4105KPY Small multidrug resistance protein FOC08_RS06255 ENOG4105NF4 modulator of drug activity FOC08_RS06260 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC08_RS06265 ENOG4105E5W Transporter FOC08_RS06275 ENOG4107RKG DJ-1/PfpI family FOC08_RS06280 ENOG4105CH6 catalase FOC08_RS06290 ENOG4105D5Q Arginine ornithine antiporter FOC08_RS06295 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC08_RS06305 ENOG4105C26 Dehydrogenase FOC08_RS06310 ENOG4105BZ1 (ABC) transporter FOC08_RS06325 ENOG4105DRP amino acid AbC transporter FOC08_RS06330 ENOG4105CDA abc transporter atp-binding protein FOC08_RS06345 ENOG410839P FOC08_RS06380 ENOG4107FQX Alpha-acetolactate decarboxylase FOC08_RS06410 ENOG4105D4P Coproporphyrinogen iii oxidase FOC08_RS06425 ENOG4105CHH sulfate transporter FOC08_RS06465 ENOG4106AKK s-layer domain-containing protein FOC08_RS06475 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC08_RS06480 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC08_RS06495 ENOG4105CGU Enoyl-CoA hydratase FOC08_RS06515 ENOG4105DER m42 family FOC08_RS06535 ENOG4105CTU Proline racemase FOC08_RS06575 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC08_RS06585 ENOG4108JQ7 (ABC) transporter FOC08_RS06590 ENOG4105PKS Excinuclease abc c subunit domain protein FOC08_RS06620 ENOG4105CSH Transporter FOC08_RS06630 ENOG4108MRH transcriptional regulatory protein FOC08_RS06680 ENOG4105CDU Replicative dna helicase FOC08_RS06710 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC08_RS06755 ENOG4107P5I polyketide synthase FOC08_RS06760 ENOG4108IG5 Transcriptional regulator FOC08_RS06780 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC08_RS06800 ENOG4105CMT Dihydroxyacetone kinase FOC08_RS06810 ENOG4105CMT Dihydroxyacetone kinase FOC08_RS06815 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC08_RS06820 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC08_RS06850 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC08_RS06915 ENOG4105WN5 stage II sporulation protein FOC08_RS06925 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC08_RS06935 ENOG4108MJI response regulator FOC08_RS06940 ENOG4105BZU Histidine kinase FOC08_RS06945 ENOG4105BZU Histidine kinase FOC08_RS06965 ENOG4105K8R UPF0145 protein FOC08_RS06995 ENOG4107VRP DNA repair exonuclease FOC08_RS07005 ENOG4105D7V transposase FOC08_RS07020 ENOG4108IND Tetr family transcriptional regulator FOC08_RS07025 ENOG4105EQ0 Major Facilitator superfamily FOC08_RS07045 ENOG4108MUZ hydrolase FOC08_RS07065 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC08_RS07080 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC08_RS07090 ENOG4105EMN RNA polymerase sigma factor FOC08_RS07115 ENOG4105C57 major facilitator superfamily FOC08_RS07120 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC08_RS07130 ENOG4105EEM helicase FOC08_RS07135 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC08_RS07160 ENOG4105K59 histidine triad (HIT) protein FOC08_RS07190 ENOG410905X membrane-flanked domain protein FOC08_RS07235 ENOG410905X membrane-flanked domain protein FOC08_RS07240 ENOG4105CKV Membrane FOC08_RS07245 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC08_RS07250 ENOG4105BZ4 penicillin-binding protein FOC08_RS07255 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOC08_RS07265 ENOG4105C1Q protoporphyrinogen oxidase FOC08_RS07290 ENOG4105NA0 Transcriptional regulator FOC08_RS07305 ENOG4105ECB domain protein FOC08_RS07335 ENOG4106AXD FOC08_RS07340 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC08_RS07345 ENOG4105DF9 Lipoate-protein, ligase FOC08_RS07355 ENOG4105CEY Amp-dependent synthetase and ligase FOC08_RS07385 ENOG4105CNA YD repeat protein FOC08_RS07420 ENOG4107TVP HD domain protein FOC08_RS07430 ENOG4108AEY RNA polymerase sigma factor FOC08_RS07435 ENOG41086D8 Transcriptional regulator FOC08_RS07450 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC08_RS07475 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC08_RS07480 ENOG4105C8Q Methyl-accepting chemotaxis FOC08_RS07500 ENOG4105ZU5 s-layer protein FOC08_RS07505 ENOG4107QP3 malate synthase g FOC08_RS07520 ENOG4105VEQ Cold shock protein FOC08_RS07535 ENOG4105XVF Competence transcription factor FOC08_RS07550 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination FOC08_RS07555 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC08_RS07600 ENOG4105ERH Fumarylacetoacetate hydrolase FOC08_RS07625 ENOG4105CAQ asparagine synthetase FOC08_RS07630 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC08_RS07635 ENOG4105CH6 catalase FOC08_RS07660 ENOG4105QNR S1 RNA binding domain protein FOC08_RS07670 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC08_RS07680 ENOG4107AYK membrAne FOC08_RS07685 ENOG41073B9 FOC08_RS07695 ENOG4108KP7 hydrolase FOC08_RS07705 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC08_RS07730 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC08_RS07735 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC08_RS07750 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC08_RS07765 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC08_RS07770 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC08_RS07780 ENOG4108JQ7 (ABC) transporter FOC08_RS07785 ENOG4105UQX Mate efflux family protein FOC08_RS07805 ENOG4108ZCF integral membrane protein FOC08_RS07815 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC08_RS07825 ENOG4105DPN Oligoendopeptidase f FOC08_RS07835 ENOG4108Z18 K06886 hemoglobin FOC08_RS07840 ENOG4105MIX Adenylate cyclase FOC08_RS07855 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC08_RS07860 ENOG4105EMS pseudouridine synthase FOC08_RS07880 ENOG4105K64 Glycosyl transferase, family 2 FOC08_RS07900 ENOG4107TVC Glycosyl transferase, family 2 FOC08_RS07920 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC08_RS07925 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC08_RS07935 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC08_RS07985 ENOG4108WVJ 2'-5' rna ligase FOC08_RS08010 ENOG4105CK7 Sodium proline symporter FOC08_RS08015 ENOG4105CRQ synthase (Component I) FOC08_RS08020 ENOG4105DDQ anthranilate synthase FOC08_RS08115 ENOG4105C7S Dehydrogenase FOC08_RS08125 ENOG4105VZ8 Transcriptional regulator FOC08_RS08185 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC08_RS08195 ENOG4105DZ1 carboxypeptidase FOC08_RS08200 ENOG4105VFR signal peptidase FOC08_RS08235 ENOG4105C26 Dehydrogenase FOC08_RS08240 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC08_RS08245 ENOG4105F38 ABC transporter, permease FOC08_RS08250 ENOG4105D38 putrescine abc transporter FOC08_RS08255 ENOG4107RUE extracellular solute-binding protein family 1 FOC08_RS08265 ENOG4105EYF MMPL domain protein FOC08_RS08275 ENOG4108YBP pseudouridine synthase FOC08_RS08285 ENOG4105K4I Scp-like extracellular FOC08_RS08290 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC08_RS08295 ENOG4105CQB FAD linked oxidase domain protein FOC08_RS08310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC08_RS08315 ENOG4105BZU Histidine kinase FOC08_RS08320 ENOG4105JXH GntR family transcriptional regulator FOC08_RS08340 ENOG4106A3R peptidase FOC08_RS08350 ENOG4108QTI )-transporter FOC08_RS08355 ENOG4107TS3 membrane protein, TerC FOC08_RS08360 ENOG4105CZN Potassium uptake protein FOC08_RS08365 ENOG410681C small acid-soluble spore protein FOC08_RS08370 ENOG4108Z7G MaoC domain protein dehydratase FOC08_RS08390 ENOG4105CHR reductase FOC08_RS08400 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC08_RS08415 ENOG4105C4Y ABC transporter FOC08_RS08430 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FOC08_RS08445 ENOG4105E98 transcriptional regulator DeoR family FOC08_RS08465 ENOG4105PXI polysaccharide deacetylase FOC08_RS08475 ENOG4105BZU Histidine kinase FOC08_RS08480 ENOG41090MY MarR family Transcriptional regulator FOC08_RS08490 ENOG4106DF1 FOC08_RS08495 ENOG4105BZU Histidine kinase FOC08_RS08505 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC08_RS08510 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC08_RS08545 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC08_RS08565 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC08_RS08570 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC08_RS08575 ENOG4105CZV ABC transporter FOC08_RS08585 ENOG4105CJ1 ABC, transporter FOC08_RS08625 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC08_RS08630 ENOG4105EA8 2-Nitropropane dioxygenase FOC08_RS08635 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC08_RS08645 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC08_RS08665 ENOG4105NQC Flavodoxin FOC08_RS08690 ENOG4107QMU Mate efflux family protein FOC08_RS08695 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC08_RS08725 ENOG4105CZN Potassium uptake protein FOC08_RS08730 ENOG41063Y9 FOC08_RS08735 ENOG4105KBJ sporulation protein ytfj FOC08_RS08760 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC08_RS08765 ENOG4105C7K acetolactate synthase FOC08_RS08770 ENOG4108ZP8 Acetolactate synthase small subunit FOC08_RS08775 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC08_RS08785 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOC08_RS08810 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC08_RS08845 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC08_RS08860 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC08_RS08865 ENOG4105E0M Sulfatase FOC08_RS08875 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC08_RS08895 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC08_RS08900 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC08_RS08910 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC08_RS08915 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC08_RS08920 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC08_RS08925 ENOG4105C8J )-transporter FOC08_RS08945 ENOG4105DFD Na H antiporter FOC08_RS08965 ENOG4105ENE Histidine kinase FOC08_RS08970 ENOG4105WH1 Two component transcriptional regulator luxr family FOC08_RS08990 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC08_RS09015 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC08_RS09035 ENOG4105CJ3 phosphate transporter FOC08_RS09040 ENOG4107GRR phosphate transport regulator FOC08_RS09045 ENOG4105BZ4 penicillin-binding protein FOC08_RS09065 ENOG4105I3N Conserved Protein FOC08_RS09080 ENOG4105BZU Histidine kinase FOC08_RS09115 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC08_RS09120 ENOG4105DZ1 carboxypeptidase FOC08_RS09125 ENOG4108JIC nucleoside recognition domain protein FOC08_RS09135 ENOG4105FE9 pseudouridine synthase FOC08_RS09145 ENOG4107TWT Cytochrome c biogenesis protein FOC08_RS09150 ENOG4105CRE cytochrome C FOC08_RS09155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC08_RS09160 ENOG4105BZU Histidine kinase FOC08_RS09165 ENOG4108WBT adenosyltransferase FOC08_RS09180 ENOG4108SAX Membrane FOC08_RS09190 ENOG4105T7X FOC08_RS09195 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC08_RS09200 ENOG4105I7S Abortive infection protein FOC08_RS09215 ENOG4107X2D transcriptional regulator, merr family FOC08_RS09220 ENOG4108S6Z Negative regulator of genetic competence FOC08_RS09245 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC08_RS09250 ENOG4105HDK L-asparaginase FOC08_RS09285 ENOG4105S2F FOC08_RS09290 ENOG41065D1 FOC08_RS09320 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC08_RS09335 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC08_RS09345 ENOG4105EAH synthase FOC08_RS09365 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC08_RS09370 ENOG41068YB TPR repeat-containing protein FOC08_RS09385 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC08_RS09390 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC08_RS09395 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC08_RS09425 ENOG4108JYZ YitT family FOC08_RS09430 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC08_RS09445 ENOG4105FJR Lmbe family FOC08_RS09450 ENOG4105CPK Glycosyl transferase (Group 1 FOC08_RS09485 ENOG4105DVT helicase FOC08_RS09490 ENOG4105YAC FOC08_RS09510 ENOG4105CSM endonuclease III FOC08_RS09520 ENOG4105BZ4 penicillin-binding protein FOC08_RS09575 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC08_RS09585 ENOG4105DVT helicase FOC08_RS09590 ENOG4105CTD carboxy-peptidase FOC08_RS09605 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC08_RS09620 ENOG4105C2W permease FOC08_RS09625 ENOG4105DHF Membrane FOC08_RS09630 ENOG410890F Dynamin family FOC08_RS09640 ENOG4108W0I acetyltransferase FOC08_RS09650 ENOG4105KHC sulfurtransferase FOC08_RS09750 ENOG4108SZE gCN5-related N-acetyltransferase FOC08_RS09770 ENOG41081VK Ribonuclease FOC08_RS09835 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC08_RS09845 ENOG4107RWR Sodium hydrogen exchanger FOC08_RS09855 ENOG4108Z5V transcriptional regulator, merr family FOC08_RS09865 ENOG4105H67 Protein of unknown function (DUF421) FOC08_RS09870 ENOG41080C8 DUF218 domain FOC08_RS09925 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC08_RS09935 ENOG4107R0U MotA TolQ exbB proton channel FOC08_RS09940 ENOG4105ER2 Ompa motb domain protein FOC08_RS09945 ENOG4107YTP response regulator receiver protein FOC08_RS09955 ENOG4105DD5 Flagellar motor switch protein FOC08_RS09970 ENOG4105BZU Histidine kinase FOC08_RS09990 ENOG4105E1Q flagellar hook-associated protein FOC08_RS10015 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC08_RS10020 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC08_RS10025 ENOG41075Z6 flagellar hook-basal body complex protein fliE FOC08_RS10035 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC08_RS10070 ENOG4105BZE flagellar hook protein, FlgE FOC08_RS10095 ENOG4105K64 Glycosyl transferase, family 2 FOC08_RS10130 ENOG4105I03 Flagellin FOC08_RS10135 ENOG4105E4C Lytic transglycosylase catalytic FOC08_RS10150 ENOG4105DD5 Flagellar motor switch protein FOC08_RS10160 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC08_RS10165 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC08_RS10175 ENOG4105D00 flagellar biosynthetic protein flhB FOC08_RS10180 ENOG4105D7B Flagellar biosynthesis protein flha FOC08_RS10190 ENOG4105KTQ flagellar basal-body rod protein FOC08_RS10195 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC08_RS10220 ENOG4108RZE Tetr family transcriptional regulator FOC08_RS10240 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC08_RS10265 ENOG4105DUM transcriptional regulator, lysR family FOC08_RS10270 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC08_RS10275 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC08_RS10280 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC08_RS10285 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC08_RS10325 ENOG4105CVJ phosphoglycerate mutase FOC08_RS10355 ENOG4105CAQ asparagine synthetase FOC08_RS10375 ENOG4105PGM cation diffusion facilitator family transporter FOC08_RS10385 ENOG4105DRR Transcriptional regulator, GntR family FOC08_RS10390 ENOG4108UZ3 Transporter FOC08_RS10395 ENOG4105CKI cobalamin synthesis protein FOC08_RS10400 ENOG4108PJD permease FOC08_RS10415 ENOG4105DFD Na H antiporter FOC08_RS10420 ENOG4105C9Q fumarate hydratase class II FOC08_RS10445 ENOG4105EC3 peptidase S51, dipeptidase E FOC08_RS10465 ENOG4107QIV Cytochrome c biogenesis protein FOC08_RS10495 ENOG4106BRA Membrane FOC08_RS10530 ENOG4105CJ1 ABC, transporter FOC08_RS10550 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC08_RS10560 ENOG4108IJ0 Aspartate ammonia-lyase FOC08_RS10565 ENOG4105C6K Malic enzyme FOC08_RS10625 ENOG4105FVX FOC08_RS10665 ENOG4105CSR polyphosphate kinase 2 FOC08_RS10685 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC08_RS10695 ENOG4105EU0 Major facilitator Superfamily FOC08_RS10700 ENOG4105C6T cysteine synthase FOC08_RS10720 ENOG4105C8J )-transporter FOC08_RS10730 ENOG4105X5K response regulator receiver protein FOC08_RS10735 ENOG4105H67 Protein of unknown function (DUF421) FOC08_RS10750 ENOG4106KE4 Dehydrogenase FOC08_RS10765 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC08_RS10770 ENOG4105CHR reductase FOC08_RS10775 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC08_RS10780 ENOG4105C7K acetolactate synthase FOC08_RS10785 ENOG4108ZP8 Acetolactate synthase small subunit FOC08_RS10790 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC08_RS10800 ENOG4105C7B Threonine dehydratase FOC08_RS10825 ENOG4105C6X Major Facilitator FOC08_RS10830 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC08_RS10840 ENOG4105DY9 regulatoR FOC08_RS10845 ENOG4105CYC Transferase FOC08_RS10865 ENOG4105F6J Alpha beta hydrolase fold FOC08_RS10900 ENOG41068WN FOC08_RS10920 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC08_RS10925 ENOG4105C72 UPF0176 protein FOC08_RS10935 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC08_RS10965 ENOG4107RHR regulatoR FOC08_RS10975 ENOG4105D9N nucleoside FOC08_RS10980 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC08_RS11015 ENOG4107RAQ aminopeptidase FOC08_RS11020 ENOG4107STQ Multicopper oxidase FOC08_RS11065 ENOG4108T5E Copper resistance protein FOC08_RS11070 ENOG4105KTB nuclear export factor GLE1 FOC08_RS11080 ENOG4107RT3 EamA-like transporter family FOC08_RS11085 ENOG4105GZI Transcriptional regulator FOC08_RS11090 ENOG4108Z40 Transcriptional regulator FOC08_RS11095 ENOG4107ZXU DSBA oxidoreductase FOC08_RS11100 ENOG4108TVJ Nitroreductase FOC08_RS11105 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC08_RS11110 ENOG4106F5Q Membrane FOC08_RS11115 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC08_RS11125 ENOG4105CKI cobalamin synthesis protein FOC08_RS11145 ENOG4108Z7G MaoC domain protein dehydratase FOC08_RS11150 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC08_RS11160 ENOG4105C0Z ABC transporter FOC08_RS11165 ENOG4108IV0 ABC, transporter FOC08_RS11170 ENOG4105C32 Amino acid ABC transporter (Permease) FOC08_RS11180 ENOG4105SKE transcriptional Regulator LysR family FOC08_RS11200 ENOG4105YGB Transcriptional regulator FOC08_RS11210 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC08_RS11215 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC08_RS11220 ENOG4108JJ9 ABC, transporter FOC08_RS11225 ENOG4108JJ8 (ABC) transporter FOC08_RS11275 ENOG4105EFI regulatoR FOC08_RS11280 ENOG4105BZU Histidine kinase FOC08_RS11300 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC08_RS11305 ENOG4108ZJ4 polysaccharide deacetylase FOC08_RS11325 ENOG4105D6E homoserine dehydrogenase FOC08_RS11350 ENOG4108KGH TRANSCRIPTIONal FOC08_RS11360 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC08_RS11365 ENOG4105BZU Histidine kinase FOC08_RS11370 ENOG4107VMI polysaccharide deacetylase FOC08_RS11380 ENOG4105KT7 mgtC SapB transporter FOC08_RS11385 ENOG4105VRR gCN5-related N-acetyltransferase FOC08_RS11395 ENOG4105DUU IucA IucC family protein FOC08_RS11400 ENOG4105CEY Amp-dependent synthetase and ligase FOC08_RS11415 ENOG4108WBH protein TIM barrel FOC08_RS11420 ENOG4105YWU small acid-soluble spore protein FOC08_RS11430 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC08_RS11480 ENOG4105KRN Transcriptional regulator, abrb family FOC08_RS11490 ENOG4105YVS arsR family transcriptional regulator FOC08_RS11495 ENOG4107SET aldo keto reductase FOC08_RS11500 ENOG4107XZQ multidrug resistance protein FOC08_RS11525 ENOG4105C8Q Methyl-accepting chemotaxis FOC08_RS11540 ENOG4108K88 Membrane FOC08_RS11545 ENOG4108WPJ Ferritin-like domain FOC08_RS11560 ENOG4105DEN Luciferase family FOC08_RS11580 ENOG4107QM2 Aldo Keto reductase FOC08_RS11585 ENOG4105CKI cobalamin synthesis protein FOC08_RS11640 ENOG4105DSE periplasmic solute binding protein FOC08_RS11645 ENOG4105K4T epimerase FOC08_RS11655 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC08_RS11680 ENOG4105CVJ phosphoglycerate mutase FOC08_RS11700 ENOG4107T5V SNARE associated Golgi FOC08_RS11715 ENOG4108PJD permease FOC08_RS11725 ENOG4108S4H thioesterase Superfamily protein FOC08_RS11735 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC08_RS11755 ENOG4105SXS Protein of unknown function (DUF456) FOC08_RS11760 ENOG4105C37 (CBS) domain FOC08_RS11780 ENOG4108Z7R Chaperone CsaA FOC08_RS11800 ENOG4108ZRV stage ii sporulation protein p FOC08_RS11810 ENOG4108VXD carboxy-peptidase FOC08_RS11820 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC08_RS11845 ENOG4108X4Q Hydrolase FOC08_RS11855 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC08_RS11860 ENOG4107RBS Methyltransferase FOC08_RS11875 ENOG41087PP glycosyltransferase MGT family FOC08_RS11880 ENOG4108JYZ YitT family FOC08_RS11885 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC08_RS11910 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC08_RS11960 ENOG4105KBJ sporulation protein ytfj FOC08_RS11985 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC08_RS12010 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC08_RS12020 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC08_RS12025 ENOG4105EMN RNA polymerase sigma factor FOC08_RS12050 ENOG4108V06 Glutathione peroxidase FOC08_RS12065 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC08_RS12085 ENOG4108IUE nitrate reductase beta subunit FOC08_RS12090 ENOG4105R3A Nitrate reductase FOC08_RS12115 ENOG4107V6Q Cyclic nucleotide-binding domain FOC08_RS12120 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC08_RS12125 ENOG4105D06 uba thif-type nad fad binding protein FOC08_RS12130 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC08_RS12135 ENOG4108ZAF Molybdopterin FOC08_RS12160 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC08_RS12165 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC08_RS12170 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC08_RS12175 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC08_RS12180 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC08_RS12185 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC08_RS12220 ENOG4105MCT stage V sporulation protein S FOC08_RS12235 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC08_RS12255 ENOG4105C5H ABC transporter FOC08_RS12270 ENOG4108UUM single-stranded DNA-binding protein FOC08_RS12300 ENOG4107YX5 Pfam:DUF548 FOC08_RS12305 ENOG4105C75 arginyL-tRNA synthetase FOC08_RS12330 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC08_RS12350 ENOG4105C5S asparaginyl-tRNA synthetase FOC08_RS12370 ENOG4105EC2 ftsk spoIIIe FOC08_RS12440 ENOG4105BZW Glycerate kinase FOC08_RS12445 ENOG4107QPK )-transporter FOC08_RS12450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC08_RS12455 ENOG41062D9 Histidine kinase FOC08_RS12470 ENOG4105C8J )-transporter FOC08_RS12490 ENOG4107XGZ Hydrolase FOC08_RS12495 ENOG4105CY2 Citrate transporter FOC08_RS12500 ENOG4105C0A alcohol dehydrogenase FOC08_RS12515 ENOG4105KD7 acetyltransferase FOC08_RS12545 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC08_RS12565 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC08_RS12580 ENOG4107RVG penicillin-binding protein FOC08_RS12585 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC08_RS12590 ENOG4105E9Q Acyl-transferase FOC08_RS12595 ENOG4108UT2 hemolysin iii FOC08_RS12605 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC08_RS12615 ENOG4108RCR degv family FOC08_RS12620 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC08_RS12625 ENOG4108KF3 Electron transport protein SCO1 SenC FOC08_RS12630 ENOG4107Y70 Heat shock protein FOC08_RS12635 ENOG4105CAQ asparagine synthetase FOC08_RS12650 ENOG4108MES Periplasmic binding protein FOC08_RS12655 ENOG4105F0I Aminotransferase FOC08_RS12690 ENOG4105D8X mechanosensitive ion channel FOC08_RS12695 ENOG4105BZU Histidine kinase FOC08_RS12700 ENOG4105WH1 Two component transcriptional regulator luxr family FOC08_RS12735 ENOG4105CMG Carbohydrate kinase FOC08_RS12740 ENOG4105CMG Carbohydrate kinase FOC08_RS12770 ENOG4108IJ8 ABC transporter FOC08_RS12775 ENOG4105E90 ABC transporter FOC08_RS12810 ENOG4105C37 (CBS) domain FOC08_RS12835 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC08_RS12850 ENOG4107S4Y M20 DapE family protein YgeY FOC08_RS12855 ENOG4108TSC N-acetyltransferase FOC08_RS12860 ENOG4108JUB Transcriptional regulator FOC08_RS12865 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC08_RS12905 ENOG4108N23 SpoOM-related protein FOC08_RS12910 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC08_RS12920 ENOG4105SZ6 Thioredoxin FOC08_RS12935 ENOG4108IBT Inherit from COG: transposase FOC08_RS13040 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC08_RS13080 ENOG4105BZ4 penicillin-binding protein FOC08_RS13085 ENOG4105CZM Major Facilitator FOC08_RS13090 ENOG4105W8X HesB YadR YfhF-family protein FOC08_RS13100 ENOG4105DXD 2-methylcitrate dehydratase FOC08_RS13105 ENOG4105CR4 methylisocitrate lyase FOC08_RS13110 ENOG4105C1G acyl-Coa dehydrogenase FOC08_RS13115 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC08_RS13125 ENOG4105N14 lysine exporter protein LysE YggA FOC08_RS13130 ENOG4105E39 Enoyl-CoA hydratase FOC08_RS13145 ENOG4107RFY SbcCD D subunit FOC08_RS13150 ENOG4105EYH Exonuclease FOC08_RS13170 ENOG4105FCD Major Facilitator FOC08_RS13175 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC08_RS13180 ENOG4105E4F Isochorismate synthase FOC08_RS13185 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC08_RS13190 ENOG4105WQI isochorismatase FOC08_RS13195 ENOG4105CEY Amp-dependent synthetase and ligase FOC08_RS13200 ENOG4105WQT MbtH domain protein FOC08_RS13205 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC08_RS13220 ENOG4105K70 DNA-binding protein FOC08_RS13240 ENOG4105BZG amino acid carrier protein FOC08_RS13260 ENOG4105FE9 pseudouridine synthase FOC08_RS13265 ENOG4105C22 threonyL-tRNA synthetase FOC08_RS13280 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC08_RS13305 ENOG4108D32 Methyltransferase FOC08_RS13335 ENOG41081I9 integral membrane protein FOC08_RS13350 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC08_RS13360 ENOG4105EYF MMPL domain protein FOC08_RS13385 ENOG4105WCN acetyltransferase FOC08_RS13415 ENOG4105C1Q protoporphyrinogen oxidase FOC08_RS13425 ENOG41068WN FOC08_RS13435 ENOG4105VEQ Cold shock protein FOC08_RS13455 ENOG410667J hydrolase FOC08_RS13490 ENOG4107V2S Transcriptional regulator FOC08_RS13495 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC08_RS13510 ENOG4105DND Transcriptional regulator FOC08_RS13515 ENOG4108RPX mosc domain containing protein FOC08_RS13530 ENOG4105BZ1 (ABC) transporter FOC08_RS13535 ENOG4105BZ1 (ABC) transporter FOC08_RS13555 ENOG4108JCI Transcriptional regulator FOC08_RS13585 ENOG4108KPJ rna polymerase sigma factor FOC08_RS13635 ENOG4105RD7 BadF BadG BcrA BcrD FOC08_RS13645 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC08_RS13665 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC08_RS13680 ENOG4105C1J atp-dependent rna helicase FOC08_RS13695 ENOG4108RZE Tetr family transcriptional regulator FOC08_RS13715 ENOG41088CC tellurite resistance protein tehB FOC08_RS13725 ENOG4108I0C methyltransferase FOC08_RS13730 ENOG4107RA9 decarboxylase FOC08_RS13735 ENOG41090HR transcriptional regulator FOC08_RS13765 ENOG4105CIN aminoacyl-histidine dipeptidase FOC08_RS13790 ENOG4107RF6 penicillin-binding protein FOC08_RS13805 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC08_RS13810 ENOG4105ETE Transcriptional regulator (LacI family FOC08_RS13815 ENOG4105IE8 Alpha-ketoglutarate permease FOC08_RS13820 ENOG4105CK5 oxidoreductase FOC08_RS13845 ENOG4105D2N Aldolase FOC08_RS13850 ENOG4105DH8 myo-inositol catabolism FOC08_RS13880 ENOG4105VZ8 Transcriptional regulator FOC08_RS13895 ENOG4108VXD carboxy-peptidase FOC08_RS13915 ENOG41067SE Tetr family transcriptional regulator FOC08_RS13920 ENOG4105C5H ABC transporter FOC08_RS13930 ENOG4105BZU Histidine kinase FOC08_RS13945 ENOG4106ANW SMI1_KNR4 FOC08_RS13950 ENOG4105CEP NADH dehydrogenase FOC08_RS13955 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC08_RS13970 ENOG4105CJ1 ABC, transporter FOC08_RS13980 ENOG4107Z3H Transcriptional regulator, TetR family FOC08_RS13995 ENOG4105C1G acyl-Coa dehydrogenase FOC08_RS14000 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC08_RS14005 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC08_RS14010 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC08_RS14015 ENOG4105E39 Enoyl-CoA hydratase FOC08_RS14020 ENOG4107QX3 carboxylase FOC08_RS14025 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC08_RS14035 ENOG4105WCN acetyltransferase FOC08_RS14040 ENOG4105DBI uridine monophosphokinase FOC08_RS14055 ENOG4105DZ1 carboxypeptidase FOC08_RS14070 ENOG4105T9C HD domain FOC08_RS14080 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC08_RS14120 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC08_RS14120 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC08_RS14135 ENOG4105FQP Beta-lactamase FOC08_RS14145 ENOG4107Y80 Major Facilitator superfamily FOC08_RS14160 ENOG4105CUV Homoserine Kinase FOC08_RS14195 ENOG4105CPQ Dehydrogenase FOC08_RS14300 ENOG4105ETU transcriptional activator (TenA FOC08_RS14400 ENOG410667J hydrolase FOC08_RS14410 ENOG4105BZU Histidine kinase FOC08_RS14415 ENOG4107RF6 penicillin-binding protein FOC08_RS14435 ENOG4108JJB ABC transporter FOC08_RS14450 ENOG4108HGU Histidine kinase FOC08_RS14465 ENOG4105CB2 alcohol dehydrogenase FOC08_RS14470 ENOG4105CJN penicillin-binding protein FOC08_RS14480 ENOG4105FQP Beta-lactamase FOC08_RS14515 ENOG4108V4B ThiJ pfpI FOC08_RS14545 ENOG4107Y80 Major Facilitator superfamily FOC08_RS14560 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC08_RS14580 ENOG4107Y9U Membrane FOC08_RS14610 ENOG4105FCD Major Facilitator FOC08_RS14625 ENOG4105E09 nadh pyrophosphatase FOC08_RS14630 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC08_RS14635 ENOG4108Z4K mutator MutT protein FOC08_RS14670 ENOG4108XI2 Domain of unknown function (DUF1963) FOC08_RS14700 ENOG4105KWG Pfam:DUF1696 FOC08_RS14735 ENOG4105PKS Excinuclease abc c subunit domain protein FOC08_RS14775 ENOG4107VFR oxidoreductase FOC08_RS14800 ENOG4105PAD Hydrolase FOC08_RS14820 ENOG4105DY8 decarboxylase FOC08_RS14835 ENOG4108IUM Glycogen debranching enzyme FOC08_RS14860 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC08_RS14870 ENOG4105FDR Membrane FOC08_RS14905 ENOG4108V3A UPF0421 protein FOC08_RS14925 ENOG4105MSI germination protein ypeb FOC08_RS14945 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FOC08_RS14950 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC08_RS14955 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FOC08_RS14960 ENOG4107Z3H Transcriptional regulator, TetR family FOC08_RS14990 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC08_RS15005 ENOG4105E98 transcriptional regulator DeoR family FOC08_RS15025 ENOG41062ES Transcriptional regulator FOC08_RS15045 ENOG4107QKR Dehydrogenase FOC08_RS15055 ENOG4107RUY (E1 component), alpha subunit FOC08_RS15065 ENOG4105E1F short-chain dehydrogenase reductase FOC08_RS15070 ENOG4105RHY Pfam:UPF0157 FOC08_RS15100 ENOG4107SQ8 Glycine betaine FOC08_RS15105 ENOG4108IJ7 Glycine betaine FOC08_RS15130 ENOG4105E66 phosphoriboisomerase A FOC08_RS15135 ENOG41082BV acetyltransferase FOC08_RS15140 ENOG4108M1A Chitin-binding protein FOC08_RS15175 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC08_RS15225 ENOG4105EEM helicase FOC08_RS15245 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC08_RS15290 ENOG4108M1A Chitin-binding protein FOC08_RS15310 ENOG4105BZG amino acid carrier protein FOC08_RS15315 ENOG4105C26 Dehydrogenase FOC08_RS15320 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC08_RS15325 ENOG4105CTU Proline racemase FOC08_RS15330 ENOG4105CTU Proline racemase FOC08_RS15335 ENOG41080HI glycine oxidase FOC08_RS15375 ENOG4107T5V SNARE associated Golgi FOC08_RS15390 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC08_RS15395 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC08_RS15410 ENOG4105DTQ mandelate racemase muconate lactonizing FOC08_RS15455 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC08_RS15460 ENOG4105BZU Histidine kinase FOC08_RS15500 ENOG4105DPN Oligoendopeptidase f FOC08_RS15515 ENOG4105EPR degv family FOC08_RS15555 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC08_RS15560 ENOG4106K7D Major facilitator family transporter FOC08_RS15580 ENOG4107BMA Transglycosylase associated protein FOC08_RS15595 ENOG41089UC methyltransferase, type 11 FOC08_RS15630 ENOG4105CHM Aminotransferase FOC08_RS15700 ENOG4105C02 permease FOC08_RS15710 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC08_RS15715 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC08_RS15720 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC08_RS15745 ENOG4105E09 nadh pyrophosphatase FOC08_RS15765 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC08_RS15815 ENOG4107VC0 DNA alkylation repair enzyme FOC08_RS15825 ENOG4107VMI polysaccharide deacetylase FOC08_RS15835 ENOG4108ZCF integral membrane protein FOC08_RS15840 ENOG4105E0M Sulfatase FOC08_RS15845 ENOG4105C5H ABC transporter FOC08_RS15855 ENOG4105EYF MMPL domain protein FOC08_RS15860 ENOG4105EYF MMPL domain protein FOC08_RS15865 ENOG4105EYF MMPL domain protein FOC08_RS15870 ENOG41082JN Transcriptional regulator FOC08_RS15890 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC08_RS15895 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC08_RS15900 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC08_RS15935 ENOG41069ER domain protein FOC08_RS15945 ENOG4105EMN RNA polymerase sigma factor FOC08_RS15970 ENOG4105D4B ABC, transporter FOC08_RS15980 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC08_RS15990 ENOG4105DKT Transcriptional regulator FOC08_RS16005 ENOG41061GT Aldolase FOC08_RS16025 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC08_RS16055 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC08_RS16060 ENOG4105II7 pyrroline-5-carboxylate reductase FOC08_RS16070 ENOG4107258 Transcriptional regulator FOC08_RS16080 ENOG4105E0Y RtcB Protein FOC08_RS16085 ENOG4105ECK Fatty Acid Desaturase FOC08_RS16090 ENOG4105G6Z alkaline phosphatase FOC08_RS16100 ENOG4105VMP Transcriptional regulator FOC08_RS16115 ENOG41090T1 Membrane FOC08_RS16125 ENOG4108WCX response regulator FOC08_RS16135 ENOG41068WN FOC08_RS16160 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC08_RS16185 ENOG4105CKK Glycosyl transferase, family 2 FOC08_RS16210 ENOG4105CKK Glycosyl transferase, family 2 FOC08_RS16220 ENOG4105C8Y Acetylornithine aminotransferase FOC08_RS16260 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC08_RS16270 ENOG4108TVJ Nitroreductase FOC08_RS16275 ENOG4105FS7 Transcriptional regulator FOC08_RS16310 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC08_RS16320 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC08_RS16350 ENOG4108XET gCN5-related N-acetyltransferase FOC08_RS16430 ENOG410635A Membrane FOC08_RS16435 ENOG4105KNA -acetyltransferase FOC08_RS16440 ENOG4108IQI permease FOC08_RS16450 ENOG4105F1N DNA alkylation repair FOC08_RS16495 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC08_RS16530 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC08_RS16535 ENOG4107258 Transcriptional regulator FOC08_RS16545 ENOG4106N3A copper homeostasis protein cutc FOC08_RS16550 ENOG4108ZRV stage ii sporulation protein p FOC08_RS16555 ENOG4108ZHR arsR family transcriptional regulator FOC08_RS16565 ENOG4105FDT acyl-CoA dehydrogenase FOC08_RS16580 ENOG4105DWD nucleoside recognition domain protein FOC08_RS16610 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC08_RS16670 ENOG4105E2A Dehydrogenase FOC08_RS16685 ENOG4108IJ0 Aspartate ammonia-lyase FOC08_RS16690 ENOG4105HDK L-asparaginase FOC08_RS16695 ENOG4108IMY Transcriptional regulator FOC08_RS16705 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC08_RS16710 ENOG4105CUB amino acid FOC08_RS16720 ENOG4105II7 pyrroline-5-carboxylate reductase FOC08_RS16730 ENOG4105C6K Malic enzyme FOC08_RS16765 ENOG4105CSV Glutaminase FOC08_RS16800 ENOG4105CGH 5'-nucleotidase FOC08_RS16805 ENOG4105CH6 catalase FOC08_RS16815 ENOG4105CHJ isochorismatase hydrolase FOC08_RS16840 ENOG41090MY MarR family Transcriptional regulator FOC08_RS16875 ENOG4108606 TspO/MBR family FOC08_RS16880 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC08_RS16895 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC08_RS16900 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC08_RS16915 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC08_RS16920 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC08_RS16925 ENOG4105DSE periplasmic solute binding protein FOC08_RS16930 ENOG4105CC5 ABC transporter FOC08_RS16935 ENOG4105DIK (ABC) transporter FOC08_RS16965 ENOG4105D6J arsenicaL-resistance protein FOC08_RS16970 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC08_RS16975 ENOG41085FC arsR family transcriptional regulator FOC08_RS16990 ENOG4105F7F Chaperone FOC08_RS17000 ENOG4105CHR reductase FOC08_RS17005 ENOG4108YXU transcriptional regulator AsnC family FOC08_RS17080 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC08_RS17085 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC08_RS17095 ENOG4105IIP Membrane FOC08_RS17110 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC08_RS17115 ENOG41062D9 Histidine kinase FOC08_RS17140 ENOG4105K6H D-cysteine desulfhydrase FOC08_RS17160 ENOG4105VZ8 Transcriptional regulator FOC08_RS17175 ENOG4108NNI Beta-lactamase domain-containing protein FOC08_RS17180 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC08_RS17190 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC08_RS17195 ENOG4105JQZ Methyltransferase FOC08_RS17210 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC08_RS17215 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC08_RS17230 ENOG4105BZU Histidine kinase FOC08_RS17245 ENOG4108U05 Transcriptional regulator FOC08_RS17260 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC08_RS17265 ENOG4105DJB Major Facilitator Superfamily FOC08_RS17270 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FOC08_RS17275 ENOG4107QR9 Iron-sulfur cluster binding protein FOC08_RS17285 ENOG4106P55 Transcriptional regulator FOC08_RS17295 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC08_RS17325 ENOG4105TRI Hydrolase FOC08_RS17355 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC08_RS17385 ENOG4107QJQ Mate efflux family protein FOC08_RS17405 ENOG4105EQ0 Major Facilitator superfamily FOC08_RS17410 ENOG4108JGH Tetr family transcriptional regulator FOC08_RS17425 ENOG4105C44 Serine transporter FOC08_RS17430 ENOG4105EJQ L-serine dehydratase FOC08_RS17445 ENOG4108JPW Aminotransferase FOC08_RS17460 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC08_RS17470 ENOG4105DVH amino acid FOC08_RS17485 ENOG4108JQ1 Dehydrogenase FOC08_RS17505 ENOG4108AEY RNA polymerase sigma factor FOC08_RS17520 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC08_RS17525 ENOG410874W AraC family transcriptional regulator FOC08_RS17575 ENOG4108ISG Major Facilitator FOC08_RS17585 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC08_RS17590 ENOG4105CZM Major Facilitator FOC08_RS17610 ENOG4105DA5 (ABC) transporter FOC08_RS17615 ENOG41069JR FOC08_RS17625 ENOG4105RXJ FOC08_RS17630 ENOG4105KPY Small multidrug resistance protein FOC08_RS17635 ENOG4105KBX Transcriptional regulator, TetR family FOC08_RS17645 ENOG4105CRW Short chain fatty acid transporter FOC08_RS17655 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC08_RS17685 ENOG4108JJB ABC transporter FOC08_RS17690 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC08_RS17715 ENOG4108K8S endonuclease I FOC08_RS17730 ENOG41067QW Transcriptional regulator FOC08_RS17740 ENOG4108Z66 YbaK ebsC protein FOC08_RS17745 ENOG4105CUT histidyl-tRNA synthetase FOC08_RS17760 ENOG4105KVH Transcriptional regulator FOC08_RS17765 ENOG4108RCM Nitroreductase FOC08_RS17785 ENOG4108PSK reductase FOC08_RS17795 ENOG4105CJ1 ABC, transporter FOC08_RS17855 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC08_RS17860 ENOG4105DKQ ROK family FOC08_RS17865 ENOG4106UW1 Major Facilitator superfamily FOC08_RS17870 ENOG4108UW5 maltose o-acetyltransferase FOC08_RS17880 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC08_RS17885 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC08_RS17890 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC08_RS17910 ENOG4105DMQ Methyltransferase FOC08_RS17920 ENOG4105EV4 Multidrug resistance protein mdtH FOC08_RS17950 ENOG4105C37 (CBS) domain FOC08_RS17965 ENOG4105DDN Pentapeptide repeat-containing protein FOC08_RS17970 ENOG4105XDF Protein of unknown function (DUF1272) FOC08_RS17975 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC08_RS17980 ENOG4105CMG Carbohydrate kinase FOC08_RS17985 ENOG4105C6Z Gluconate FOC08_RS17990 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC08_RS18005 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC08_RS18010 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC08_RS18015 ENOG4105CIS alcohol dehydrogenase FOC08_RS18020 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC08_RS18035 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC08_RS18040 ENOG4105D4Y metalloprotease FOC08_RS18060 ENOG4105CV8 reductase FOC08_RS18065 ENOG4105F27 Major Facilitator FOC08_RS18080 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC08_RS18085 ENOG4105C44 Serine transporter FOC08_RS18115 ENOG4105KVH Transcriptional regulator FOC08_RS18120 ENOG4108TZY GntR Family Transcriptional Regulator FOC08_RS18130 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC08_RS18135 ENOG4105KVH Transcriptional regulator FOC08_RS18140 ENOG4105KVH Transcriptional regulator FOC08_RS18175 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC08_RS18185 ENOG4105CHR reductase FOC08_RS18205 ENOG4105KVH Transcriptional regulator FOC08_RS18275 ENOG4105KAF membrAne FOC08_RS18300 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC08_RS18315 ENOG4107YXZ hydrolase, family 25 FOC08_RS18340 ENOG4105ED2 Beta-lactamase FOC08_RS18350 ENOG4105H3G oxidoreductase FOC08_RS18420 ENOG4108TN2 lmbE family FOC08_RS18430 ENOG4107R3E Citrate transporter FOC08_RS18450 ENOG4108MES Periplasmic binding protein FOC08_RS18455 ENOG4105EHG Permease protein FOC08_RS18460 ENOG4105DQ5 transport system permease protein FOC08_RS18465 ENOG4105NX3 Membrane FOC08_RS18470 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC08_RS18490 ENOG4107CUJ Protein of unknown function (DUF2690) FOC08_RS18500 ENOG4107V2S Transcriptional regulator FOC08_RS18520 ENOG4105C98 muts2 protein FOC08_RS18530 ENOG4105E5K Alpha-amylase FOC08_RS18540 ENOG4105DPN Oligoendopeptidase f FOC08_RS18545 ENOG4108A04 Beta-lactamase FOC08_RS18575 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC08_RS18600 ENOG41082BM Transcriptional regulator, arsr family FOC08_RS18605 ENOG4105CIS alcohol dehydrogenase FOC08_RS18630 ENOG4105RHY Pfam:UPF0157 FOC08_RS18640 ENOG4105C09 Bile acid FOC08_RS18645 ENOG4105CQB FAD linked oxidase domain protein FOC08_RS18665 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC08_RS18675 ENOG4105K64 Glycosyl transferase, family 2 FOC08_RS18680 ENOG4105E39 Enoyl-CoA hydratase FOC08_RS18690 ENOG4105KT7 mgtC SapB transporter FOC08_RS18705 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC08_RS18710 ENOG41073R8 VanW family FOC08_RS18720 ENOG4108R1P FOC08_RS18735 ENOG4105VEQ Cold shock protein FOC08_RS18755 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC08_RS18775 ENOG410904N short-chain dehydrogenase reductase FOC08_RS18785 ENOG4106IQC argininosuccinate lyase FOC08_RS18800 ENOG4108IA2 Sodium pantothenate symporter FOC08_RS18810 ENOG4105C26 Dehydrogenase FOC08_RS18815 ENOG4105CHR reductase FOC08_RS18825 ENOG4105EWU Squalene--hopene cyclase FOC08_RS18835 ENOG4105FR1 rard protein FOC08_RS18840 ENOG410696E Membrane FOC08_RS18855 ENOG4105D1F ATP-binding protein FOC08_RS18865 ENOG4108ZAF Molybdopterin FOC08_RS18870 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC08_RS18875 ENOG4105D06 uba thif-type nad fad binding protein FOC08_RS18880 ENOG4105TMB Formate nitrite transporter FOC08_RS18890 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC08_RS18895 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC08_RS18905 ENOG4108JB9 formate dehydrogenase FOC08_RS18910 ENOG4105E1K spore germination protein FOC08_RS18975 ENOG4108KGH TRANSCRIPTIONal FOC08_RS18985 ENOG4105EMN RNA polymerase sigma factor FOC08_RS19000 ENOG4105CIG ABC transporter FOC08_RS19010 ENOG4105D9R oxidoreductase FOC08_RS19020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC08_RS19025 ENOG4105K4P CoA-binding domain protein FOC08_RS19030 ENOG4105C0H protease FOC08_RS19035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC08_RS19045 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC08_RS19050 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC08_RS19055 ENOG4105W8X HesB YadR YfhF-family protein FOC08_RS19085 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC08_RS19090 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC08_RS19100 ENOG4108JJA ABC, transporter FOC08_RS19105 ENOG4108I0Z Aconitate hydratase FOC08_RS19145 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC08_RS19165 ENOG4107F3J Amp-dependent synthetase and ligase FOC08_RS19170 ENOG4107ZYJ bioY protein FOC08_RS19175 ENOG4105CEY Amp-dependent synthetase and ligase FOC08_RS19225 ENOG4107AYK membrAne FOC08_RS19235 ENOG4105BZU Histidine kinase FOC08_RS19240 ENOG4105FBA Phospholipase Carboxylesterase FOC08_RS19245 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC08_RS19250 ENOG4105CK7 Sodium proline symporter FOC08_RS19255 ENOG4105CBC glutamate synthase FOC08_RS19260 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC08_RS19265 ENOG4108VJ1 Transcriptional regulator (CarD family FOC08_RS19270 ENOG4108903 Formimidoylglutamase FOC08_RS19295 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC08_RS19355 ENOG4107QIV Cytochrome c biogenesis protein FOC08_RS19365 ENOG4107RSM transcriptional regulator FOC08_RS19370 ENOG4105VAW lrga family FOC08_RS19375 ENOG41067MG lrgb family FOC08_RS19400 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC08_RS19415 ENOG4105BZ1 (ABC) transporter FOC08_RS19420 ENOG4105BZ1 (ABC) transporter FOC08_RS19440 ENOG4105D7V transposase FOC08_RS19455 ENOG4105D5T phosphonate abc transporter FOC08_RS19475 ENOG4108SVB resolvase FOC08_RS19495 ENOG4105K7K Transcriptional regulator FOC08_RS19525 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOC08_RS19530 ENOG4105XSJ toxin secretion phage lysis holin FOC08_RS19710 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FOC08_RS19810 ENOG4105C5F glutamine synthetase FOC08_RS19815 ENOG4105KV4 Transcriptional regulator FOC08_RS19820 ENOG4105CXI aluminum resistance protein FOC08_RS19830 ENOG4105EN6 Membrane FOC08_RS19840 ENOG4106F1P AAA ATPase, central domain protein FOC08_RS19870 ENOG41069ER domain protein FOC08_RS19875 ENOG4105DM4 PTS System FOC08_RS19880 ENOG4105DE4 1-phosphofructokinase FOC08_RS19885 ENOG4105E98 transcriptional regulator DeoR family FOC08_RS19895 ENOG4108SJC Membrane FOC08_RS19905 ENOG4105C85 amino acid FOC08_RS19920 ENOG4105TMB Formate nitrite transporter FOC08_RS19925 ENOG4105K70 DNA-binding protein FOC08_RS19930 ENOG4105C59 p-type ATPase FOC08_RS19935 ENOG410681U heavy metal transport detoxification protein FOC08_RS19940 ENOG4105VPX protein, conserved in bacteria FOC08_RS19950 ENOG4105NIV Esterase FOC08_RS19955 ENOG4105E0A ABC, transporter FOC08_RS19975 ENOG4105CGK Exodeoxyribonuclease III FOC08_RS19985 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC08_RS19990 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC08_RS20020 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC08_RS20025 ENOG4105BZU Histidine kinase FOC08_RS20040 ENOG41067MG lrgb family FOC08_RS20055 ENOG4107TTQ Alpha beta hydrolase fold FOC08_RS20060 ENOG4107YEI lmbE family FOC08_RS20085 ENOG4105F0V Cell wall hydrolase FOC08_RS20090 ENOG4107R6R udp-galactopyranose mutase FOC08_RS20095 ENOG4105E0M Sulfatase FOC08_RS20100 ENOG410890F Dynamin family FOC08_RS20110 ENOG4107QHE Choloylglycine hydrolase FOC08_RS20135 ENOG4105DA5 (ABC) transporter FOC08_RS20160 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC08_RS20165 ENOG4105DQU oxidoreductase, subunit beta FOC08_RS20170 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC08_RS20175 ENOG4108IGT Dipeptidase FOC08_RS20180 ENOG4105MCT stage V sporulation protein S FOC08_RS20185 ENOG4105D48 metallophosphoesterase FOC08_RS20210 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC08_RS20225 ENOG4105XZV Protein of unknown function (DUF3243) FOC08_RS20230 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC08_RS20255 ENOG4108JQ9 ABC transporter FOC08_RS20260 ENOG4105DIH basic membrane FOC08_RS20265 ENOG4105FDP GntR family transcriptional regulator FOC08_RS20270 ENOG4107QZI cell division protein FtsK FOC08_RS20280 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC08_RS20290 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC08_RS20300 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC08_RS20305 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC08_RS20310 ENOG4105E35 Dipicolinate synthase subunit A FOC08_RS20320 ENOG4105C1V Peptidase, M16 FOC08_RS20340 ENOG4105DTN riboflavin biosynthesis protein ribF FOC08_RS20345 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC08_RS20355 ENOG4105W7A Protein of unknown function (DUF503) FOC08_RS20365 ENOG4105VHM ribosomal protein FOC08_RS20370 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC08_RS20375 ENOG4105CHV Transcription elongation factor NusA FOC08_RS20385 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC08_RS20395 ENOG4105DZP Membrane-associated zinc metalloprotease FOC08_RS20400 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC08_RS20405 ENOG4105KNE Phosphatidate cytidylyltransferase FOC08_RS20410 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC08_RS20450 ENOG4108HE4 integrase family FOC08_RS20460 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC08_RS20470 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC08_RS20485 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC08_RS20510 ENOG4105VB6 UPF0109 protein FOC08_RS20530 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC08_RS20535 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC08_RS20550 ENOG4105CHR reductase FOC08_RS20555 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC08_RS20570 ENOG4105CB5 ATP-dependent DNA helicase recG FOC08_RS20575 ENOG4105DP4 dak2 domain fusion protein ylov FOC08_RS20580 ENOG4108ZAA Alkaline-shock protein FOC08_RS20595 ENOG4105FJ0 thiamine FOC08_RS20600 ENOG4105DJV ribulose-phosphate 3-epimerase FOC08_RS20605 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC08_RS20610 ENOG4105D9P serine threonine protein kinase FOC08_RS20615 ENOG4108ZF3 Phosphatase FOC08_RS20625 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC08_RS20635 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC08_RS20640 ENOG4105C25 Primosomal protein n' FOC08_RS20645 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC08_RS20665 ENOG4105DSJ YicC domain protein FOC08_RS20675 ENOG4105F23 Fibronectin-binding protein FOC08_RS20680 ENOG4105DC7 peptidase M24 FOC08_RS20735 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOC08_RS20760 ENOG4105C34 Pseudouridine synthase FOC08_RS20775 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC08_RS20785 ENOG4105DBK s4 domain protein FOC08_RS20790 ENOG41067XK integral membrane protein FOC08_RS20800 ENOG4105DFA alanine racemase domain protein FOC08_RS20805 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC08_RS20810 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC08_RS20820 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC08_RS20830 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC08_RS20835 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC08_RS20840 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC08_RS20845 ENOG4105D4A Cell wall formation (By similarity) FOC08_RS20850 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC08_RS20855 ENOG4105CNI cell division protein FtsW FOC08_RS20870 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC08_RS20875 ENOG4105CJN penicillin-binding protein FOC08_RS20880 ENOG4105CJN penicillin-binding protein FOC08_RS20885 ENOG41068DC Essential cell division protein (By similarity) FOC08_RS20925 ENOG4105KNH Nucleic acid-binding protein FOC08_RS20975 ENOG4105XSJ toxin secretion phage lysis holin FOC08_RS21055 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC08_RS21065 ENOG4105CAR Terminase, large subunit FOC08_RS21150 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOC08_RS21165 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC08_RS21210 ENOG4108IMY Transcriptional regulator FOC08_RS21230 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC08_RS21240 ENOG41063PX domain protein FOC08_RS21245 ENOG4105D78 K07001 NTE family protein FOC08_RS21250 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC08_RS21260 ENOG4106H78 methyltransferase FOC08_RS21280 ENOG4107TB6 phosphoglycerate mutase FOC08_RS21295 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC08_RS21345 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC08_RS21350 ENOG4105CNI cell division protein FtsW FOC08_RS21365 ENOG4108IAB Phoh family FOC08_RS21385 ENOG4105QA2 FOC08_RS21390 ENOG4105CI3 gtp-binding protein typa FOC08_RS21400 ENOG4105ECY inositol monophosphatase FOC08_RS21420 ENOG4105CXN decarboxylase FOC08_RS21465 ENOG4105C7S Dehydrogenase FOC08_RS21470 ENOG4105CPP Dehydrogenase, E1 component FOC08_RS21485 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC08_RS21490 ENOG4108X4Q Hydrolase FOC08_RS21500 ENOG4105CN5 Metallo-Beta-Lactamase FOC08_RS21505 ENOG4107ZYR domain protein FOC08_RS21540 ENOG4108XRC Protein of unknown function (DUF458) FOC08_RS21545 ENOG4107IN1 Protein of unknown function (DUF1797) FOC08_RS21560 ENOG4105EPM Diguanylate phosphodiesterase FOC08_RS21565 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC08_RS21580 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC08_RS21590 ENOG4105UIN FOC08_RS21645 ENOG4108HGU Histidine kinase FOC08_RS21655 ENOG4105CHM Aminotransferase FOC08_RS21660 ENOG4105FKQ transcriptional regulator FOC08_RS21665 ENOG4105EG2 ABC transporter, permease FOC08_RS21675 ENOG4107FKK extracellular solute-binding protein family 1 FOC08_RS21685 ENOG4105CG3 alpha amylase, catalytic region FOC08_RS21730 ENOG4105CHU acetyl-coa acetyltransferase FOC08_RS21770 ENOG4105K7K Transcriptional regulator FOC08_RS21775 ENOG4105DTD Dehydrogenase FOC08_RS21785 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FOC08_RS21795 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC08_RS21820 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOC08_RS21840 ENOG4106TD9 Diguanylate cyclase FOC08_RS21860 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC08_RS21875 ENOG4105CID antiterminator FOC08_RS21885 ENOG4105FDP GntR family transcriptional regulator FOC08_RS21895 ENOG4105CE4 GlcNAc 6-P deacetylase FOC08_RS21930 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC08_RS21935 ENOG4105PTM secreted protein FOC08_RS21940 ENOG4105J7I hydrolase FOC08_RS21950 ENOG4105G6R Stage v sporulation protein ae FOC08_RS21960 ENOG4105CZ3 stage V sporulation protein ad FOC08_RS21965 ENOG41090VF Stage v sporulation protein ac FOC08_RS21985 ENOG4105C8J )-transporter FOC08_RS21990 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC08_RS22000 ENOG41082AN stage II sporulation protein FOC08_RS22005 ENOG4105DZ1 carboxypeptidase FOC08_RS22010 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC08_RS22015 ENOG4105DVE abc transporter atp-binding protein FOC08_RS22045 ENOG4105D7N magnesium and cobalt transport protein CorA FOC08_RS22070 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC08_RS22080 ENOG4105I3K Ferric uptake regulator, Fur family FOC08_RS22085 ENOG4105MZ9 stage II sporulation protein m FOC08_RS22105 ENOG4105CPC Aldo Keto reductase FOC08_RS22115 ENOG4105RHY Pfam:UPF0157 FOC08_RS22135 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC08_RS22145 ENOG4105ETE Transcriptional regulator (LacI family FOC08_RS22150 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC08_RS22170 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC08_RS22175 ENOG4108R6K riboflavin synthase, subunit alpha FOC08_RS22195 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FOC08_RS22200 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC08_RS22205 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC08_RS22210 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC08_RS22220 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC08_RS22230 ENOG4105DFD Na H antiporter FOC08_RS22235 ENOG4105CGH 5'-nucleotidase FOC08_RS22275 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC08_RS22290 ENOG4108IXY short-chain dehydrogenase reductase FOC08_RS22300 ENOG4105II7 pyrroline-5-carboxylate reductase FOC08_RS22305 ENOG4105EJQ L-serine dehydratase FOC08_RS22330 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC08_RS22340 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC08_RS22345 ENOG4105D9U N-acetyltransferase FOC08_RS22360 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC08_RS22365 ENOG4108QEG Membrane FOC08_RS22370 ENOG4105CDA abc transporter atp-binding protein FOC08_RS22375 ENOG4105E5Q amino acid AbC transporter FOC08_RS22380 ENOG4108HW3 (ABC) transporter FOC08_RS22390 ENOG4105G7B Protein of unknown function (DUF2992) FOC08_RS22405 ENOG4105C7S Dehydrogenase FOC08_RS22410 ENOG4105CPP Dehydrogenase, E1 component FOC08_RS22430 ENOG4107RDP Dehydrogenase FOC08_RS22440 ENOG4108JUB Transcriptional regulator FOC08_RS22450 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC08_RS22465 ENOG4107QQR Sporulation FOC08_RS22470 ENOG4105S1Z Stage IV sporulation protein B FOC08_RS22475 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC08_RS22485 ENOG4105DX0 Hemolysin A FOC08_RS22495 ENOG4105CTB Polyprenyl synthetase FOC08_RS22520 ENOG4108ZSR alkaline shock protein FOC08_RS22525 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC08_RS22550 ENOG410644B Stage III sporulation protein af FOC08_RS22560 ENOG4105KQ4 Stage iii sporulation protein ad FOC08_RS22565 ENOG4108CQH stage III sporulation protein AC FOC08_RS22570 ENOG4105KR5 Stage iii sporulation protein FOC08_RS22575 ENOG4105CD2 stage iii sporulation protein aa FOC08_RS22600 ENOG4105DC7 peptidase M24 FOC08_RS22615 ENOG4105CBJ Metal-dependent enzyme FOC08_RS22625 ENOG4107YBY Hydrolase FOC08_RS22645 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC08_RS22650 ENOG4105WZW rhodanese family FOC08_RS22670 ENOG41080TC multidrug resistance protein FOC08_RS22705 ENOG4105CJ1 ABC, transporter FOC08_RS22710 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC08_RS22740 ENOG4105C0D helicase FOC08_RS22860 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC08_RS22865 ENOG4105C3R Methionine synthase FOC08_RS22875 ENOG4105C28 cystathionine FOC08_RS22880 ENOG4105C28 cystathionine FOC08_RS22900 ENOG4105C5X domain protein FOC08_RS22910 ENOG4105DKQ ROK family FOC08_RS22920 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC08_RS22935 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC08_RS22940 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC08_RS22945 ENOG4105E2Z phosphate ABC transporter (Permease FOC08_RS22950 ENOG4105C8U phosphate abc transporter FOC08_RS22955 ENOG4105PWN phosphate abc transporter FOC08_RS22960 ENOG4107RF6 penicillin-binding protein FOC08_RS22970 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC08_RS22995 ENOG4105N80 Ferric uptake regulator, Fur family FOC08_RS23005 ENOG4105FDK ABC transporter FOC08_RS23010 ENOG4108JYZ YitT family FOC08_RS23015 ENOG41069ZM Protein of unknown function (DUF2624) FOC08_RS23040 ENOG4105EGD dinuclear metal center protein, YbgI family FOC08_RS23055 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC08_RS23060 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC08_RS23085 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC08_RS23090 ENOG4105KG3 cytidine deaminase FOC08_RS23095 ENOG4107YR5 Diacylglycerol kinase FOC08_RS23105 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC08_RS23110 ENOG4105C9A Phoh family FOC08_RS23120 ENOG41068P3 sporulation protein YqfC FOC08_RS23125 ENOG4105KTH gatB Yqey FOC08_RS23135 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC08_RS23140 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC08_RS23160 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOC08_RS23170 ENOG4105CSA Coproporphyrinogen iii oxidase FOC08_RS23175 ENOG4105KVH Transcriptional regulator FOC08_RS23200 ENOG4105TQK DNA polymerase iii, delta' subunit FOC08_RS23210 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC08_RS23215 ENOG4108UK2 deaminase FOC08_RS23220 ENOG4105KQC Competence protein FOC08_RS23230 ENOG4105DXX methyltransferase FOC08_RS23240 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC08_RS23250 ENOG410812S Rna-binding protein FOC08_RS23260 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC08_RS23265 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC08_RS23280 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC08_RS23300 ENOG4108TVJ Nitroreductase FOC08_RS23315 ENOG4105G6Z alkaline phosphatase FOC08_RS23325 ENOG4108MUZ hydrolase FOC08_RS23360 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC08_RS23365 ENOG4105MIR Phenylalanine 4-monooxygenase FOC08_RS23415 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC08_RS23420 ENOG4108V5C ABC transporter FOC08_RS23430 ENOG4108EKI Dehydrogenase FOC08_RS23435 ENOG4105C28 cystathionine FOC08_RS23465 ENOG4107XRG penicillin-binding protein FOC08_RS23480 ENOG4105CFP Peptidase U32 FOC08_RS23485 ENOG4105XYU peptidase (U32 family) FOC08_RS23490 ENOG4108VQJ O-methyltransferase FOC08_RS23495 ENOG4105HHA aminodeoxychorismate lyase FOC08_RS23515 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC08_RS23525 ENOG4105C02 permease FOC08_RS23540 ENOG41060CR FOC08_RS23545 ENOG4105C7H Helicase, RecD TraA family FOC08_RS23555 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC08_RS23560 ENOG4105C3J Cysteine desulfurase FOC08_RS23570 ENOG4105D1H recombination factor protein RarA FOC08_RS23575 ENOG4108VCI transcription factor, rsfa family FOC08_RS23580 ENOG4105CUZ uba thif-type nad fad binding protein FOC08_RS23590 ENOG4105CUT histidyl-tRNA synthetase FOC08_RS23600 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC08_RS23610 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC08_RS23615 ENOG41076HS cation diffusion facilitator family transporter FOC08_RS23620 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC08_RS23630 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC08_RS23635 ENOG4108QG2 Membrane FOC08_RS23645 ENOG4105VIE preprotein translocase, subunit YajC FOC08_RS23660 ENOG41061AI Protein of unknown function (DUF2905) FOC08_RS23675 ENOG4108HUF Transporter FOC08_RS23685 ENOG4108IPJ Membrane FOC08_RS23690 ENOG4108IPJ Membrane FOC08_RS23695 ENOG41082BM Transcriptional regulator, arsr family FOC08_RS23720 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC08_RS23725 ENOG4108IYU L-aspartate oxidase FOC08_RS23740 ENOG4108RPX mosc domain containing protein FOC08_RS23745 ENOG4105CQC Prephenate dehydratase FOC08_RS23775 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC08_RS23790 ENOG4105X36 (ribosomal) protein FOC08_RS23800 ENOG4105C03 ribonuclease FOC08_RS23815 ENOG4107QMS site-determining protein FOC08_RS23830 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOC08_RS23835 ENOG4105DFF Rod shape-determining protein mreb FOC08_RS23855 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC08_RS23860 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC08_RS23870 ENOG41068KH stage VI sporulation protein D FOC08_RS23880 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC08_RS23905 ENOG4105K56 Transcriptional regulator FOC08_RS23925 ENOG4108IUQ atp-dependent protease FOC08_RS23950 ENOG4108QCI YvbH-like oligomerisation region FOC08_RS23970 ENOG4105M59 Phosphodiesterase, mj0936 family FOC08_RS23975 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOC08_RS23985 ENOG4108XJQ germination protein FOC08_RS23995 ENOG4108PCX Major Facilitator FOC08_RS24005 ENOG4105KBX Transcriptional regulator, TetR family FOC08_RS24020 ENOG4105PFC Transcriptional regulator FOC08_RS24035 ENOG4105DZC cytosine deaminase FOC08_RS24040 ENOG4105DZC cytosine deaminase FOC08_RS24045 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC08_RS24050 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC08_RS24065 ENOG4108JQ7 (ABC) transporter FOC08_RS24075 ENOG4105DY9 regulatoR FOC08_RS24090 ENOG41067S9 phage shock protein C, PspC FOC08_RS24095 ENOG4108JCI Transcriptional regulator FOC08_RS24105 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC08_RS24110 ENOG4108Z40 Transcriptional regulator FOC08_RS24115 ENOG4105RHA ABC transporter, permease FOC08_RS24120 ENOG4108IUX (ABC) transporter FOC08_RS24125 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC08_RS24135 ENOG4105E14 MotA TolQ exbB proton channel FOC08_RS24140 ENOG4108VXD carboxy-peptidase FOC08_RS24150 ENOG4105E33 succinate dehydrogenase FOC08_RS24160 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC08_RS24175 ENOG4105K63 Thioredoxin FOC08_RS24180 ENOG4105C10 Electron transfer flavoprotein FOC08_RS24185 ENOG4105BZJ Electron transfer flavoprotein FOC08_RS24190 ENOG41060WC Enoyl-CoA hydratase FOC08_RS24195 ENOG4107Z3H Transcriptional regulator, TetR family FOC08_RS24200 ENOG4105CEY Amp-dependent synthetase and ligase FOC08_RS24210 ENOG4105J76 Periplasmic binding protein FOC08_RS24215 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC08_RS24255 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC08_RS24265 ENOG4105DR4 Methyltransferase FOC08_RS24280 ENOG4105KFN sortase, SrtB family FOC08_RS24285 ENOG4105E0A ABC, transporter FOC08_RS24300 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC08_RS24310 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC08_RS24320 ENOG4105FE9 pseudouridine synthase FOC08_RS24330 ENOG4105DCG PHP domain protein FOC08_RS24365 ENOG4105C5S asparaginyl-tRNA synthetase FOC08_RS24370 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC08_RS24380 ENOG4108RWN rrna methyltransferase FOC08_RS24415 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC08_RS24420 ENOG4105CW7 secretion protein, HlyD family FOC08_RS24425 ENOG4108JGH Tetr family transcriptional regulator FOC08_RS24430 ENOG4105CN9 Peptidase m42 family protein FOC08_RS24450 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC08_RS24455 ENOG4105C22 threonyL-tRNA synthetase FOC08_RS24460 ENOG4108TDW sporulation protein YtxC FOC08_RS24480 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC08_RS24490 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC08_RS24495 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC08_RS24505 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC08_RS24510 ENOG4105C2M dna polymerase I FOC08_RS24515 ENOG4105BZU Histidine kinase FOC08_RS24520 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC08_RS24535 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC08_RS24540 ENOG4105BZN citrate synthase FOC08_RS24550 ENOG4108REF Sporulation integral membrane protein ytvi FOC08_RS24555 ENOG4105FS0 cytoplasmic membrane protein FOC08_RS24580 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC08_RS24585 ENOG4105C6K Malic enzyme FOC08_RS24590 ENOG4105C0B DNA polymerase III (alpha subunit) FOC08_RS24595 ENOG4105VV2 FOC08_RS24605 ENOG4105SFS phosphoesterase RecJ domain protein FOC08_RS24640 ENOG4105DC7 peptidase M24 FOC08_RS24675 ENOG4105Z7P Acetyltransferase (GNAT) family FOC08_RS24680 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC08_RS24690 ENOG4105VZ8 Transcriptional regulator FOC08_RS24710 ENOG4107YZX Universal stress protein FOC08_RS24750 ENOG4108JYZ YitT family FOC08_RS24770 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC08_RS24780 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC08_RS24785 ENOG4105KBJ sporulation protein ytfj FOC08_RS24800 ENOG4105EFZ amidohydrolase FOC08_RS24810 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC08_RS24835 ENOG4106KR7 LysR family Transcriptional regulator FOC08_RS24855 ENOG4105C28 cystathionine FOC08_RS24875 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC08_RS24885 ENOG4105EMN RNA polymerase sigma factor FOC08_RS24905 ENOG4105F1V Acetoin utilization protein FOC08_RS24910 ENOG4105W87 Cbs domain FOC08_RS24915 ENOG4105DGU Histone deacetylase FOC08_RS24925 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC08_RS24935 ENOG4107SNB ankyrin repeat protein YahD FOC08_RS24940 ENOG4105EP9 oxidoreductase FOC08_RS24970 ENOG4105ETE Transcriptional regulator (LacI family FOC08_RS24990 ENOG4105C88 aminopeptidase FOC08_RS25035 ENOG4108VDD TRNA binding domain protein FOC08_RS25065 ENOG4105C8F Beta-lactamase domain protein FOC08_RS25080 ENOG4108V15 phosphotransferase enzyme family FOC08_RS25085 ENOG4108IUM Glycogen debranching enzyme FOC08_RS25100 ENOG4105YW5 deoR family transcriptional regulator FOC08_RS25115 ENOG4105CBX hi0933 family FOC08_RS25150 ENOG4108VJ1 Transcriptional regulator (CarD family FOC08_RS25155 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC08_RS25160 ENOG4105CSC Glucose uptake protein FOC08_RS25175 ENOG4108ZAF Molybdopterin FOC08_RS25180 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC08_RS25185 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC08_RS25195 ENOG4105D06 uba thif-type nad fad binding protein FOC08_RS25220 ENOG41085GJ domain protein FOC08_RS25230 ENOG4105DWV Homoserine O-trans-acetylase FOC08_RS25240 ENOG4108B31 Spore germination protein FOC08_RS25270 ENOG410605W Major Facilitator FOC08_RS25275 ENOG4107S91 Sodium hydrogen exchanger FOC08_RS25280 ENOG4105NCW Trka-c domain protein FOC08_RS25295 ENOG4105C19 ABC transporter FOC08_RS25315 ENOG4105N5T Radical SAM Protein FOC08_RS25325 ENOG4105DA5 (ABC) transporter FOC08_RS25355 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC08_RS25360 ENOG4108Z0R Transferase FOC08_RS25365 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC08_RS25370 ENOG4105BZF Glycosyl transferase (Group 1 FOC08_RS25380 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC08_RS25430 ENOG4105EGD dinuclear metal center protein, YbgI family FOC08_RS25435 ENOG4105BZU Histidine kinase FOC08_RS25440 ENOG4105BZU Histidine kinase FOC08_RS25445 ENOG4107S9D Alpha beta hydrolase FOC08_RS25465 ENOG4105D2X ABC transporter substrate-binding protein FOC08_RS25475 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC08_RS25530 ENOG4108V2W Carbonate dehydratase FOC08_RS25535 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC08_RS25540 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC08_RS25585 ENOG41087YS Phage shock protein A FOC08_RS25620 ENOG4105BZU Histidine kinase FOC08_RS25625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC08_RS25650 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC08_RS25655 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC08_RS25690 ENOG4107ZTW SNARE associated Golgi FOC08_RS25705 ENOG4105C19 ABC transporter FOC08_RS25710 ENOG41086D8 Transcriptional regulator FOC08_RS25750 ENOG4105C6Z Gluconate FOC08_RS25755 ENOG4105FDP GntR family transcriptional regulator FOC08_RS25775 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC08_RS25805 ENOG4105DTQ mandelate racemase muconate lactonizing FOC08_RS25815 ENOG4108IPT Naphthoate synthase FOC08_RS25820 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC08_RS25825 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOC08_RS25830 ENOG4105E4F Isochorismate synthase FOC08_RS25835 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC08_RS25845 ENOG4105VEQ Cold shock protein FOC08_RS25865 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOC08_RS25875 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOC08_RS25895 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC08_RS25990 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC08_RS26025 ENOG4105KT7 mgtC SapB transporter FOC08_RS26030 ENOG4107PBV potassium channel FOC08_RS26040 ENOG4107QYV phosphohexose isomerase FOC08_RS26045 ENOG4105WG9 Conserved Protein FOC08_RS26055 ENOG4105CHM Aminotransferase FOC08_RS26060 ENOG4108ZB6 transcriptional regulator AsnC family FOC08_RS26065 ENOG4105C5I Dehydrogenase FOC08_RS26070 ENOG4108MUZ hydrolase FOC08_RS26080 ENOG4105C87 Aminotransferase class I and II FOC08_RS26090 ENOG4105Y38 Kinase-associated protein B FOC08_RS26100 ENOG4107R3E Citrate transporter FOC08_RS26115 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FOC08_RS26120 ENOG4105KA0 thioesterase Superfamily protein FOC08_RS26140 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC08_RS26160 ENOG41069ER domain protein FOC08_RS26175 ENOG4105CEP NADH dehydrogenase FOC08_RS26205 ENOG4105EWC Purine nucleoside phosphorylase FOC08_RS26225 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC08_RS26250 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC08_RS26255 ENOG4105C4B ABC transporter, permease FOC08_RS26260 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC08_RS26305 ENOG41083MR nifu domain-containing protein FOC08_RS26320 ENOG4108W5N phosphatidylglycerophosphatase a FOC08_RS26330 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC08_RS26335 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC08_RS26350 ENOG4105CBT Fructose-1,6-bisphosphatase FOC08_RS26365 ENOG4105MMD transcriptional regulator FOC08_RS26370 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC08_RS26375 ENOG4107TXC Transcriptional regulator FOC08_RS26380 ENOG41090T1 Membrane FOC08_RS26405 ENOG4105FAA peptidase M23 FOC08_RS26415 ENOG4105KZD Domain of unknown function (DUF1805) FOC08_RS26420 ENOG4107R8B 5'-nucleotidase FOC08_RS26435 ENOG4105DIW FeS assembly protein SUFB FOC08_RS26440 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC08_RS26445 ENOG4105C9B Cysteine desulfurase FOC08_RS26450 ENOG4105JRK feS assembly protein SufD FOC08_RS26455 ENOG4105C3K feS assembly ATPase SufC FOC08_RS26460 ENOG4105D01 (LipO)protein FOC08_RS26465 ENOG4105D01 (LipO)protein FOC08_RS26470 ENOG4108UMI ABC transporter, permease FOC08_RS26505 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC08_RS26550 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC08_RS26575 ENOG4108W8B Beta-lactamase domain protein FOC08_RS26580 ENOG4105C1G acyl-Coa dehydrogenase FOC08_RS26585 ENOG4105CHU acetyl-coa acetyltransferase FOC08_RS26600 ENOG4105DZ1 carboxypeptidase FOC08_RS26620 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC08_RS26635 ENOG4108SUT Major Facilitator Superfamily FOC08_RS26640 ENOG4107R7I amino acid FOC08_RS26650 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC08_RS26660 ENOG4107AYK membrAne FOC08_RS26695 ENOG4107ZTW SNARE associated Golgi FOC08_RS26705 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC08_RS26710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC08_RS26715 ENOG4105BZU Histidine kinase FOC08_RS26725 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC08_RS26740 ENOG4105VG1 fes assembly suf system protein FOC08_RS26745 ENOG4105D4Y metalloprotease FOC08_RS26765 ENOG4107S91 Sodium hydrogen exchanger FOC08_RS26770 ENOG4105NCW Trka-c domain protein FOC08_RS26780 ENOG4108RMU ferritin dps family protein FOC08_RS26795 ENOG4108URH decarboxylase FOC08_RS26815 ENOG4105D9N nucleoside FOC08_RS26820 ENOG4105D9N nucleoside FOC08_RS26835 ENOG4108RYK Nad-dependent epimerase dehydratase FOC08_RS26850 ENOG4105CV8 reductase FOC08_RS26855 ENOG4105F27 Major Facilitator FOC08_RS26860 ENOG4105KVH Transcriptional regulator FOC08_RS26875 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC08_RS26880 ENOG4105D4A Cell wall formation (By similarity) FOC08_RS26890 ENOG4105C8Q Methyl-accepting chemotaxis FOC08_RS26900 ENOG4105WMR Protein CrcB homolog FOC08_RS26905 ENOG4105WMR Protein CrcB homolog FOC08_RS26920 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC08_RS26925 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FOC08_RS26940 ENOG4108IPW abc transporter atp-binding protein FOC08_RS26945 ENOG4105CM4 permease protein FOC08_RS26975 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC08_RS26985 ENOG4105XZU Preprotein translocase, subunit SecG FOC08_RS26990 ENOG41067MG lrgb family FOC08_RS27080 ENOG4108QY5 Ferric enterobactin transport protein