locus-tag class description FOC09_RS00030 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC09_RS00040 ENOG4105T9C HD domain FOC09_RS00055 ENOG4105DZ1 carboxypeptidase FOC09_RS00070 ENOG4105DBI uridine monophosphokinase FOC09_RS00075 ENOG4105WCN acetyltransferase FOC09_RS00085 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC09_RS00090 ENOG4107QX3 carboxylase FOC09_RS00095 ENOG4105E39 Enoyl-CoA hydratase FOC09_RS00100 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC09_RS00105 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC09_RS00110 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC09_RS00115 ENOG4105C1G acyl-Coa dehydrogenase FOC09_RS00130 ENOG4107Z3H Transcriptional regulator, TetR family FOC09_RS00140 ENOG4105CJ1 ABC, transporter FOC09_RS00155 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC09_RS00160 ENOG4105CEP NADH dehydrogenase FOC09_RS00165 ENOG4106ANW SMI1_KNR4 FOC09_RS00180 ENOG4105BZU Histidine kinase FOC09_RS00190 ENOG4105C5H ABC transporter FOC09_RS00195 ENOG41067SE Tetr family transcriptional regulator FOC09_RS00215 ENOG4108VXD carboxy-peptidase FOC09_RS00230 ENOG4105VZ8 Transcriptional regulator FOC09_RS00260 ENOG4105DH8 myo-inositol catabolism FOC09_RS00265 ENOG4105D2N Aldolase FOC09_RS00290 ENOG4105CK5 oxidoreductase FOC09_RS00295 ENOG4105IE8 Alpha-ketoglutarate permease FOC09_RS00300 ENOG4105ETE Transcriptional regulator (LacI family FOC09_RS00305 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC09_RS00320 ENOG4107RF6 penicillin-binding protein FOC09_RS00345 ENOG4105CIN aminoacyl-histidine dipeptidase FOC09_RS00375 ENOG41090HR transcriptional regulator FOC09_RS00380 ENOG4107RA9 decarboxylase FOC09_RS00385 ENOG4108I0C methyltransferase FOC09_RS00395 ENOG41088CC tellurite resistance protein tehB FOC09_RS00415 ENOG4108RZE Tetr family transcriptional regulator FOC09_RS00430 ENOG4105C1J atp-dependent rna helicase FOC09_RS00445 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC09_RS00465 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC09_RS00475 ENOG4105RD7 BadF BadG BcrA BcrD FOC09_RS00525 ENOG4108KPJ rna polymerase sigma factor FOC09_RS00555 ENOG4108JCI Transcriptional regulator FOC09_RS00575 ENOG4105BZ1 (ABC) transporter FOC09_RS00580 ENOG4105BZ1 (ABC) transporter FOC09_RS00595 ENOG4108RPX mosc domain containing protein FOC09_RS00600 ENOG4105DND Transcriptional regulator FOC09_RS00615 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC09_RS00620 ENOG4107V2S Transcriptional regulator FOC09_RS00655 ENOG410667J hydrolase FOC09_RS00675 ENOG4105VEQ Cold shock protein FOC09_RS00685 ENOG41068WN FOC09_RS00695 ENOG4105C1Q protoporphyrinogen oxidase FOC09_RS00725 ENOG4105WCN acetyltransferase FOC09_RS00750 ENOG4105EYF MMPL domain protein FOC09_RS00760 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC09_RS00775 ENOG41081I9 integral membrane protein FOC09_RS00805 ENOG4108D32 Methyltransferase FOC09_RS00830 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC09_RS00845 ENOG4105C22 threonyL-tRNA synthetase FOC09_RS00850 ENOG4105FE9 pseudouridine synthase FOC09_RS00870 ENOG4105BZG amino acid carrier protein FOC09_RS00890 ENOG4105K70 DNA-binding protein FOC09_RS00905 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC09_RS00910 ENOG4105WQT MbtH domain protein FOC09_RS00915 ENOG4105CEY Amp-dependent synthetase and ligase FOC09_RS00920 ENOG4105WQI isochorismatase FOC09_RS00925 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC09_RS00930 ENOG4105E4F Isochorismate synthase FOC09_RS00935 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC09_RS00940 ENOG4105FCD Major Facilitator FOC09_RS00960 ENOG4105EYH Exonuclease FOC09_RS00965 ENOG4107RFY SbcCD D subunit FOC09_RS00980 ENOG4105E39 Enoyl-CoA hydratase FOC09_RS00985 ENOG4105N14 lysine exporter protein LysE YggA FOC09_RS00995 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC09_RS01000 ENOG4105C1G acyl-Coa dehydrogenase FOC09_RS01005 ENOG4105CR4 methylisocitrate lyase FOC09_RS01010 ENOG4105DXD 2-methylcitrate dehydratase FOC09_RS01020 ENOG4105W8X HesB YadR YfhF-family protein FOC09_RS01025 ENOG4105CZM Major Facilitator FOC09_RS01030 ENOG4105BZ4 penicillin-binding protein FOC09_RS01070 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC09_RS01175 ENOG4108IBT Inherit from COG: transposase FOC09_RS01190 ENOG4105SZ6 Thioredoxin FOC09_RS01200 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC09_RS01205 ENOG4108N23 SpoOM-related protein FOC09_RS01245 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC09_RS01250 ENOG4108JUB Transcriptional regulator FOC09_RS01255 ENOG4108TSC N-acetyltransferase FOC09_RS01260 ENOG4107S4Y M20 DapE family protein YgeY FOC09_RS01275 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC09_RS01300 ENOG4105C37 (CBS) domain FOC09_RS01335 ENOG4105E90 ABC transporter FOC09_RS01340 ENOG4108IJ8 ABC transporter FOC09_RS01365 ENOG4105CMG Carbohydrate kinase FOC09_RS01370 ENOG4105CMG Carbohydrate kinase FOC09_RS01405 ENOG4105WH1 Two component transcriptional regulator luxr family FOC09_RS01410 ENOG4105BZU Histidine kinase FOC09_RS01415 ENOG4105D8X mechanosensitive ion channel FOC09_RS01450 ENOG4105F0I Aminotransferase FOC09_RS01455 ENOG4108MES Periplasmic binding protein FOC09_RS01470 ENOG4105CAQ asparagine synthetase FOC09_RS01475 ENOG4107Y70 Heat shock protein FOC09_RS01480 ENOG4108KF3 Electron transport protein SCO1 SenC FOC09_RS01485 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC09_RS01490 ENOG4108RCR degv family FOC09_RS01500 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC09_RS01510 ENOG4108UT2 hemolysin iii FOC09_RS01515 ENOG4105E9Q Acyl-transferase FOC09_RS01520 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC09_RS01525 ENOG4107RVG penicillin-binding protein FOC09_RS01540 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC09_RS01560 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC09_RS01590 ENOG4105KD7 acetyltransferase FOC09_RS01605 ENOG4105C0A alcohol dehydrogenase FOC09_RS01610 ENOG4105CY2 Citrate transporter FOC09_RS01615 ENOG4107XGZ Hydrolase FOC09_RS01635 ENOG4105C8J )-transporter FOC09_RS01650 ENOG41062D9 Histidine kinase FOC09_RS01655 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_RS01660 ENOG4107QPK )-transporter FOC09_RS01665 ENOG4105BZW Glycerate kinase FOC09_RS01735 ENOG4105EC2 ftsk spoIIIe FOC09_RS01755 ENOG4105C5S asparaginyl-tRNA synthetase FOC09_RS01775 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC09_RS01800 ENOG4105C75 arginyL-tRNA synthetase FOC09_RS01805 ENOG4107YX5 Pfam:DUF548 FOC09_RS01835 ENOG4108UUM single-stranded DNA-binding protein FOC09_RS01850 ENOG4105C5H ABC transporter FOC09_RS01870 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC09_RS01885 ENOG4105MCT stage V sporulation protein S FOC09_RS01920 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC09_RS01925 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC09_RS01930 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC09_RS01935 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC09_RS01940 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC09_RS01945 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC09_RS01970 ENOG4108ZAF Molybdopterin FOC09_RS01975 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC09_RS01980 ENOG4105D06 uba thif-type nad fad binding protein FOC09_RS01985 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC09_RS01990 ENOG4107V6Q Cyclic nucleotide-binding domain FOC09_RS02015 ENOG4105R3A Nitrate reductase FOC09_RS02020 ENOG4108IUE nitrate reductase beta subunit FOC09_RS02040 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC09_RS02055 ENOG4108V06 Glutathione peroxidase FOC09_RS02080 ENOG4105EMN RNA polymerase sigma factor FOC09_RS02085 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC09_RS02095 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOC09_RS02120 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC09_RS02145 ENOG4105KBJ sporulation protein ytfj FOC09_RS02195 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC09_RS02220 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC09_RS02225 ENOG4108JYZ YitT family FOC09_RS02230 ENOG41087PP glycosyltransferase MGT family FOC09_RS02245 ENOG4107RBS Methyltransferase FOC09_RS02250 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC09_RS02260 ENOG4108X4Q Hydrolase FOC09_RS02285 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC09_RS02295 ENOG4108VXD carboxy-peptidase FOC09_RS02305 ENOG4108ZRV stage ii sporulation protein p FOC09_RS02325 ENOG4108Z7R Chaperone CsaA FOC09_RS02345 ENOG4105C37 (CBS) domain FOC09_RS02350 ENOG4105SXS Protein of unknown function (DUF456) FOC09_RS02370 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC09_RS02380 ENOG4108S4H thioesterase Superfamily protein FOC09_RS02390 ENOG4108PJD permease FOC09_RS02405 ENOG4107T5V SNARE associated Golgi FOC09_RS02425 ENOG4105CVJ phosphoglycerate mutase FOC09_RS02450 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC09_RS02460 ENOG4105K4T epimerase FOC09_RS02465 ENOG4105DSE periplasmic solute binding protein FOC09_RS02520 ENOG4105CKI cobalamin synthesis protein FOC09_RS02525 ENOG4107QM2 Aldo Keto reductase FOC09_RS02545 ENOG4105DEN Luciferase family FOC09_RS02560 ENOG4108WPJ Ferritin-like domain FOC09_RS02565 ENOG4108K88 Membrane FOC09_RS02580 ENOG4105C8Q Methyl-accepting chemotaxis FOC09_RS02605 ENOG4107XZQ multidrug resistance protein FOC09_RS02610 ENOG4107SET aldo keto reductase FOC09_RS02615 ENOG4105YVS arsR family transcriptional regulator FOC09_RS02625 ENOG4105KRN Transcriptional regulator, abrb family FOC09_RS02675 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC09_RS02685 ENOG4105YWU small acid-soluble spore protein FOC09_RS02690 ENOG4108WBH protein TIM barrel FOC09_RS02705 ENOG4105CEY Amp-dependent synthetase and ligase FOC09_RS02710 ENOG4105DUU IucA IucC family protein FOC09_RS02720 ENOG4105VRR gCN5-related N-acetyltransferase FOC09_RS02725 ENOG4105KT7 mgtC SapB transporter FOC09_RS02735 ENOG4107VMI polysaccharide deacetylase FOC09_RS02740 ENOG4105BZU Histidine kinase FOC09_RS02745 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC09_RS02755 ENOG4108KGH TRANSCRIPTIONal FOC09_RS02780 ENOG4105D6E homoserine dehydrogenase FOC09_RS02800 ENOG4108ZJ4 polysaccharide deacetylase FOC09_RS02805 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC09_RS02825 ENOG4105BZU Histidine kinase FOC09_RS02830 ENOG4105EFI regulatoR FOC09_RS02880 ENOG4108JJ8 (ABC) transporter FOC09_RS02885 ENOG4108JJ9 ABC, transporter FOC09_RS02890 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC09_RS02895 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC09_RS02905 ENOG4105YGB Transcriptional regulator FOC09_RS02915 ENOG4105MDS 4-oxalocrotonate tautomerase FOC09_RS02925 ENOG4105SKE transcriptional Regulator LysR family FOC09_RS02935 ENOG4105C32 Amino acid ABC transporter (Permease) FOC09_RS02940 ENOG4108IV0 ABC, transporter FOC09_RS02945 ENOG4105C0Z ABC transporter FOC09_RS02955 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC09_RS02960 ENOG4108Z7G MaoC domain protein dehydratase FOC09_RS02980 ENOG4105CKI cobalamin synthesis protein FOC09_RS02990 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC09_RS02995 ENOG4106F5Q Membrane FOC09_RS03000 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC09_RS03005 ENOG4108TVJ Nitroreductase FOC09_RS03010 ENOG4107ZXU DSBA oxidoreductase FOC09_RS03015 ENOG4108Z40 Transcriptional regulator FOC09_RS03020 ENOG4105GZI Transcriptional regulator FOC09_RS03025 ENOG4107RT3 EamA-like transporter family FOC09_RS03035 ENOG4105KTB nuclear export factor GLE1 FOC09_RS03040 ENOG4108T5E Copper resistance protein FOC09_RS03085 ENOG4107STQ Multicopper oxidase FOC09_RS03090 ENOG4107RAQ aminopeptidase FOC09_RS03125 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC09_RS03130 ENOG4105D9N nucleoside FOC09_RS03140 ENOG4107RHR regulatoR FOC09_RS03170 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC09_RS03180 ENOG4105C72 UPF0176 protein FOC09_RS03185 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC09_RS03205 ENOG41068WN FOC09_RS03240 ENOG4105F6J Alpha beta hydrolase fold FOC09_RS03260 ENOG4105CYC Transferase FOC09_RS03265 ENOG4105DY9 regulatoR FOC09_RS03275 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC09_RS03280 ENOG4105C6X Major Facilitator FOC09_RS03305 ENOG4105C7B Threonine dehydratase FOC09_RS03315 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC09_RS03320 ENOG4108ZP8 Acetolactate synthase small subunit FOC09_RS03325 ENOG4105C7K acetolactate synthase FOC09_RS03330 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC09_RS03335 ENOG4105CHR reductase FOC09_RS03340 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC09_RS03355 ENOG4106KE4 Dehydrogenase FOC09_RS03370 ENOG4105H67 Protein of unknown function (DUF421) FOC09_RS03375 ENOG4105X5K response regulator receiver protein FOC09_RS03385 ENOG4105C8J )-transporter FOC09_RS03405 ENOG4105C6T cysteine synthase FOC09_RS03410 ENOG4105EU0 Major facilitator Superfamily FOC09_RS03420 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC09_RS03440 ENOG4105CSR polyphosphate kinase 2 FOC09_RS03480 ENOG4105FVX FOC09_RS03540 ENOG4105C6K Malic enzyme FOC09_RS03545 ENOG4108IJ0 Aspartate ammonia-lyase FOC09_RS03555 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC09_RS03575 ENOG4105CJ1 ABC, transporter FOC09_RS03610 ENOG4106BRA Membrane FOC09_RS03640 ENOG4107QIV Cytochrome c biogenesis protein FOC09_RS03660 ENOG4105EC3 peptidase S51, dipeptidase E FOC09_RS03685 ENOG4105C9Q fumarate hydratase class II FOC09_RS03690 ENOG4105DFD Na H antiporter FOC09_RS03705 ENOG4108PJD permease FOC09_RS03710 ENOG4105CKI cobalamin synthesis protein FOC09_RS03715 ENOG4108UZ3 Transporter FOC09_RS03720 ENOG4105DRR Transcriptional regulator, GntR family FOC09_RS03730 ENOG4105PGM cation diffusion facilitator family transporter FOC09_RS03750 ENOG4105CAQ asparagine synthetase FOC09_RS03780 ENOG4105CVJ phosphoglycerate mutase FOC09_RS03820 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC09_RS03825 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC09_RS03830 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC09_RS03835 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC09_RS03840 ENOG4105DUM transcriptional regulator, lysR family FOC09_RS03865 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC09_RS03885 ENOG4108RZE Tetr family transcriptional regulator FOC09_RS03910 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC09_RS03915 ENOG4105KTQ flagellar basal-body rod protein FOC09_RS03925 ENOG4105D7B Flagellar biosynthesis protein flha FOC09_RS03930 ENOG4105D00 flagellar biosynthetic protein flhB FOC09_RS03940 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC09_RS03945 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC09_RS03955 ENOG4105DD5 Flagellar motor switch protein FOC09_RS03970 ENOG4105E4C Lytic transglycosylase catalytic FOC09_RS03975 ENOG4105I03 Flagellin FOC09_RS04010 ENOG4105K64 Glycosyl transferase, family 2 FOC09_RS04035 ENOG4105BZE flagellar hook protein, FlgE FOC09_RS04070 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC09_RS04080 ENOG41075Z6 flagellar hook-basal body complex protein fliE FOC09_RS04085 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC09_RS04090 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC09_RS04115 ENOG4105E1Q flagellar hook-associated protein FOC09_RS04135 ENOG4105BZU Histidine kinase FOC09_RS04150 ENOG4105DD5 Flagellar motor switch protein FOC09_RS04160 ENOG4107YTP response regulator receiver protein FOC09_RS04165 ENOG4105ER2 Ompa motb domain protein FOC09_RS04170 ENOG4107R0U MotA TolQ exbB proton channel FOC09_RS04180 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC09_RS04235 ENOG41080C8 DUF218 domain FOC09_RS04240 ENOG4105H67 Protein of unknown function (DUF421) FOC09_RS04250 ENOG4108Z5V transcriptional regulator, merr family FOC09_RS04260 ENOG4107RWR Sodium hydrogen exchanger FOC09_RS04270 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC09_RS04335 ENOG41081VK Ribonuclease FOC09_RS04355 ENOG4108SZE gCN5-related N-acetyltransferase FOC09_RS04455 ENOG4105KHC sulfurtransferase FOC09_RS04465 ENOG4108W0I acetyltransferase FOC09_RS04475 ENOG410890F Dynamin family FOC09_RS04480 ENOG4105DHF Membrane FOC09_RS04485 ENOG4105C2W permease FOC09_RS04500 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC09_RS04515 ENOG4105CTD carboxy-peptidase FOC09_RS04520 ENOG4105DVT helicase FOC09_RS04530 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC09_RS04585 ENOG4105BZ4 penicillin-binding protein FOC09_RS04595 ENOG4105CSM endonuclease III FOC09_RS04615 ENOG4105YAC FOC09_RS04620 ENOG4105DVT helicase FOC09_RS04655 ENOG4105CPK Glycosyl transferase (Group 1 FOC09_RS04660 ENOG4105FJR Lmbe family FOC09_RS04675 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC09_RS04680 ENOG4108JYZ YitT family FOC09_RS04710 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC09_RS04715 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC09_RS04720 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC09_RS04735 ENOG41068YB TPR repeat-containing protein FOC09_RS04740 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC09_RS04760 ENOG4105EAH synthase FOC09_RS04770 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC09_RS04785 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC09_RS04815 ENOG41065D1 FOC09_RS04820 ENOG4105S2F FOC09_RS04855 ENOG4105HDK L-asparaginase FOC09_RS04860 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC09_RS04885 ENOG4108S6Z Negative regulator of genetic competence FOC09_RS04890 ENOG4107X2D transcriptional regulator, merr family FOC09_RS04905 ENOG4105I7S Abortive infection protein FOC09_RS04910 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC09_RS04915 ENOG4105T7X FOC09_RS04925 ENOG4108SAX Membrane FOC09_RS04940 ENOG4108WBT adenosyltransferase FOC09_RS04945 ENOG4105BZU Histidine kinase FOC09_RS04950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_RS04955 ENOG4105CRE cytochrome C FOC09_RS04960 ENOG4107TWT Cytochrome c biogenesis protein FOC09_RS04970 ENOG4105FE9 pseudouridine synthase FOC09_RS04980 ENOG4108JIC nucleoside recognition domain protein FOC09_RS04985 ENOG4105DZ1 carboxypeptidase FOC09_RS04990 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC09_RS05025 ENOG4105BZU Histidine kinase FOC09_RS05040 ENOG4105I3N Conserved Protein FOC09_RS05060 ENOG4105BZ4 penicillin-binding protein FOC09_RS05065 ENOG4107GRR phosphate transport regulator FOC09_RS05070 ENOG4105CJ3 phosphate transporter FOC09_RS05090 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC09_RS05115 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC09_RS05135 ENOG4105WH1 Two component transcriptional regulator luxr family FOC09_RS05140 ENOG4105ENE Histidine kinase FOC09_RS05160 ENOG4105DFD Na H antiporter FOC09_RS05180 ENOG4105C8J )-transporter FOC09_RS05185 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC09_RS05190 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC09_RS05195 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC09_RS05205 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC09_RS05210 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC09_RS05230 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC09_RS05240 ENOG4105E0M Sulfatase FOC09_RS05245 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC09_RS05260 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC09_RS05295 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC09_RS05320 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOC09_RS05330 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC09_RS05335 ENOG4108ZP8 Acetolactate synthase small subunit FOC09_RS05340 ENOG4105C7K acetolactate synthase FOC09_RS05345 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC09_RS05370 ENOG4105KBJ sporulation protein ytfj FOC09_RS05375 ENOG41063Y9 FOC09_RS05380 ENOG4105CZN Potassium uptake protein FOC09_RS05410 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC09_RS05415 ENOG4107QMU Mate efflux family protein FOC09_RS05440 ENOG4105NQC Flavodoxin FOC09_RS05460 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC09_RS05470 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC09_RS05475 ENOG4105EA8 2-Nitropropane dioxygenase FOC09_RS05480 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC09_RS05520 ENOG4105CJ1 ABC, transporter FOC09_RS05530 ENOG4105CZV ABC transporter FOC09_RS05535 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC09_RS05540 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC09_RS05560 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC09_RS05595 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC09_RS05600 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC09_RS05610 ENOG4105BZU Histidine kinase FOC09_RS05615 ENOG4106DF1 FOC09_RS05625 ENOG41090MY MarR family Transcriptional regulator FOC09_RS05630 ENOG4105BZU Histidine kinase FOC09_RS05640 ENOG4105PXI polysaccharide deacetylase FOC09_RS05660 ENOG4105E98 transcriptional regulator DeoR family FOC09_RS05675 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FOC09_RS05690 ENOG4105C4Y ABC transporter FOC09_RS05705 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC09_RS05715 ENOG4105CHR reductase FOC09_RS05735 ENOG4108Z7G MaoC domain protein dehydratase FOC09_RS05740 ENOG410681C small acid-soluble spore protein FOC09_RS05745 ENOG4105CZN Potassium uptake protein FOC09_RS05750 ENOG4107TS3 membrane protein, TerC FOC09_RS05755 ENOG4108QTI )-transporter FOC09_RS05765 ENOG4106A3R peptidase FOC09_RS05785 ENOG4105JXH GntR family transcriptional regulator FOC09_RS05790 ENOG4105BZU Histidine kinase FOC09_RS05795 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_RS05810 ENOG4105CQB FAD linked oxidase domain protein FOC09_RS05815 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC09_RS05820 ENOG4105K4I Scp-like extracellular FOC09_RS05830 ENOG4108YBP pseudouridine synthase FOC09_RS05840 ENOG4105EYF MMPL domain protein FOC09_RS05850 ENOG4107RUE extracellular solute-binding protein family 1 FOC09_RS05855 ENOG4105D38 putrescine abc transporter FOC09_RS05860 ENOG4105F38 ABC transporter, permease FOC09_RS05865 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC09_RS05870 ENOG4105C26 Dehydrogenase FOC09_RS05905 ENOG4105VFR signal peptidase FOC09_RS05910 ENOG4105DZ1 carboxypeptidase FOC09_RS05920 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC09_RS05980 ENOG4105VZ8 Transcriptional regulator FOC09_RS05990 ENOG4105C7S Dehydrogenase FOC09_RS06085 ENOG4105DDQ anthranilate synthase FOC09_RS06090 ENOG4105CRQ synthase (Component I) FOC09_RS06095 ENOG4105CK7 Sodium proline symporter FOC09_RS06120 ENOG4108WVJ 2'-5' rna ligase FOC09_RS06170 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC09_RS06180 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC09_RS06185 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC09_RS06205 ENOG4107TVC Glycosyl transferase, family 2 FOC09_RS06225 ENOG4105K64 Glycosyl transferase, family 2 FOC09_RS06245 ENOG4105EMS pseudouridine synthase FOC09_RS06250 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC09_RS06265 ENOG4105MIX Adenylate cyclase FOC09_RS06270 ENOG4108Z18 K06886 hemoglobin FOC09_RS06280 ENOG4105DPN Oligoendopeptidase f FOC09_RS06290 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC09_RS06300 ENOG4108ZCF integral membrane protein FOC09_RS06320 ENOG4105UQX Mate efflux family protein FOC09_RS06325 ENOG4108JQ7 (ABC) transporter FOC09_RS06335 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC09_RS06340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC09_RS06355 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC09_RS06370 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC09_RS06375 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC09_RS06400 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC09_RS06410 ENOG4108KP7 hydrolase FOC09_RS06420 ENOG41073B9 FOC09_RS06425 ENOG4107AYK membrAne FOC09_RS06435 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC09_RS06445 ENOG4105QNR S1 RNA binding domain protein FOC09_RS06470 ENOG4105CH6 catalase FOC09_RS06475 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC09_RS06480 ENOG4105CAQ asparagine synthetase FOC09_RS06505 ENOG4105ERH Fumarylacetoacetate hydrolase FOC09_RS06550 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC09_RS06555 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination FOC09_RS06570 ENOG4105XVF Competence transcription factor FOC09_RS06585 ENOG4105VEQ Cold shock protein FOC09_RS06600 ENOG4107QP3 malate synthase g FOC09_RS06605 ENOG4105ZU5 s-layer protein FOC09_RS06625 ENOG4105C8Q Methyl-accepting chemotaxis FOC09_RS06630 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC09_RS06655 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC09_RS06670 ENOG41086D8 Transcriptional regulator FOC09_RS06675 ENOG4108AEY RNA polymerase sigma factor FOC09_RS06685 ENOG4107TVP HD domain protein FOC09_RS06720 ENOG4105CNA YD repeat protein FOC09_RS06750 ENOG4105CEY Amp-dependent synthetase and ligase FOC09_RS06760 ENOG4105DF9 Lipoate-protein, ligase FOC09_RS06765 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC09_RS06770 ENOG4106AXD FOC09_RS06800 ENOG4105ECB domain protein FOC09_RS06815 ENOG4105NA0 Transcriptional regulator FOC09_RS06840 ENOG4105C1Q protoporphyrinogen oxidase FOC09_RS06850 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOC09_RS06855 ENOG4105BZ4 penicillin-binding protein FOC09_RS06860 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC09_RS06865 ENOG4105CKV Membrane FOC09_RS06870 ENOG410905X membrane-flanked domain protein FOC09_RS06915 ENOG410905X membrane-flanked domain protein FOC09_RS06945 ENOG4105K59 histidine triad (HIT) protein FOC09_RS06970 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC09_RS06975 ENOG4105EEM helicase FOC09_RS06985 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC09_RS06990 ENOG4105C57 major facilitator superfamily FOC09_RS07015 ENOG4105EMN RNA polymerase sigma factor FOC09_RS07025 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC09_RS07040 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC09_RS07060 ENOG4108MUZ hydrolase FOC09_RS07080 ENOG4105EQ0 Major Facilitator superfamily FOC09_RS07085 ENOG4108IND Tetr family transcriptional regulator FOC09_RS07100 ENOG4105D7V transposase FOC09_RS07110 ENOG4107VRP DNA repair exonuclease FOC09_RS07140 ENOG4105K8R UPF0145 protein FOC09_RS07160 ENOG4105BZU Histidine kinase FOC09_RS07165 ENOG4105BZU Histidine kinase FOC09_RS07170 ENOG4108MJI response regulator FOC09_RS07180 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC09_RS07190 ENOG4105WN5 stage II sporulation protein FOC09_RS07255 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC09_RS07285 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC09_RS07290 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC09_RS07295 ENOG4105CMT Dihydroxyacetone kinase FOC09_RS07305 ENOG4105CMT Dihydroxyacetone kinase FOC09_RS07325 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC09_RS07345 ENOG4108IG5 Transcriptional regulator FOC09_RS07350 ENOG4107P5I polyketide synthase FOC09_RS07395 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC09_RS07425 ENOG4105CDU Replicative dna helicase FOC09_RS07475 ENOG4108MRH transcriptional regulatory protein FOC09_RS07485 ENOG4105CSH Transporter FOC09_RS07515 ENOG4105PKS Excinuclease abc c subunit domain protein FOC09_RS07520 ENOG4108JQ7 (ABC) transporter FOC09_RS07530 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC09_RS07570 ENOG4105CTU Proline racemase FOC09_RS07590 ENOG4105DER m42 family FOC09_RS07610 ENOG4105CGU Enoyl-CoA hydratase FOC09_RS07625 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC09_RS07630 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC09_RS07640 ENOG4106AKK s-layer domain-containing protein FOC09_RS07680 ENOG4105CHH sulfate transporter FOC09_RS07695 ENOG4105D4P Coproporphyrinogen iii oxidase FOC09_RS07725 ENOG4107FQX Alpha-acetolactate decarboxylase FOC09_RS07760 ENOG410839P FOC09_RS07775 ENOG4105CDA abc transporter atp-binding protein FOC09_RS07780 ENOG4105DRP amino acid AbC transporter FOC09_RS07795 ENOG4105BZ1 (ABC) transporter FOC09_RS07800 ENOG4105C26 Dehydrogenase FOC09_RS07810 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC09_RS07815 ENOG4105D5Q Arginine ornithine antiporter FOC09_RS07825 ENOG4105CH6 catalase FOC09_RS07830 ENOG4107RKG DJ-1/PfpI family FOC09_RS07840 ENOG4105E5W Transporter FOC09_RS07845 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC09_RS07850 ENOG4105NF4 modulator of drug activity FOC09_RS07875 ENOG4105KPY Small multidrug resistance protein FOC09_RS07880 ENOG4105KPY Small multidrug resistance protein FOC09_RS07890 ENOG4108YXU transcriptional regulator AsnC family FOC09_RS07895 ENOG4108PCN EamA-like transporter family FOC09_RS07930 ENOG4106KNT transcriptional regulator FOC09_RS07940 ENOG4107RWR Sodium hydrogen exchanger FOC09_RS07945 ENOG4105CUB amino acid FOC09_RS07975 ENOG4107T5V SNARE associated Golgi FOC09_RS08010 ENOG4105WEF catalase FOC09_RS08040 ENOG4105C19 ABC transporter FOC09_RS08045 ENOG4107RBB ABC transporter, permease FOC09_RS08050 ENOG41069ER domain protein FOC09_RS08070 ENOG4105VZJ PTS System FOC09_RS08075 ENOG4105VCP PTS System FOC09_RS08080 ENOG4105EMD TRANSCRIPTIONal FOC09_RS08105 ENOG4108KGH TRANSCRIPTIONal FOC09_RS08115 ENOG41087NI Sulfite exporter TauE/SafE FOC09_RS08120 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC09_RS08130 ENOG41085GJ domain protein FOC09_RS08135 ENOG4105VFE sira family FOC09_RS08140 ENOG4107TPS domain protein FOC09_RS08145 ENOG4105VFE sira family FOC09_RS08150 ENOG4105XTG Pfam:DUF156 FOC09_RS08155 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC09_RS08180 ENOG4105ED1 spovr family FOC09_RS08185 ENOG4107Y03 Nitroreductase FOC09_RS08240 ENOG4105C5Y PTS System FOC09_RS08270 ENOG4105C7N Xanthine uracil vitamin C permease FOC09_RS08285 ENOG4108INS Transcriptional regulator FOC09_RS08335 ENOG4105DWF phosphomethylpyrimidine kinase FOC09_RS08340 ENOG4105D06 uba thif-type nad fad binding protein FOC09_RS08355 ENOG41080HI glycine oxidase FOC09_RS08360 ENOG4108VEU Thiamine monophosphate synthase FOC09_RS08370 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC09_RS08380 ENOG4105ETU transcriptional activator (TenA FOC09_RS08400 ENOG41080XQ Signal transduction protein with cbs domains FOC09_RS08525 ENOG4105E2Z phosphate ABC transporter (Permease FOC09_RS08530 ENOG4105C8U phosphate abc transporter FOC09_RS08535 ENOG4105CVA phosphate FOC09_RS08540 ENOG4105CE1 Ferrous iron transport protein b FOC09_RS08545 ENOG4105CE1 Ferrous iron transport protein b FOC09_RS08550 ENOG4105CE1 Ferrous iron transport protein b FOC09_RS08555 ENOG4108NHD germination protein FOC09_RS08570 ENOG4105E1V na solute symporter FOC09_RS08575 ENOG4106CAD Protein of unknown function (DUF3311) FOC09_RS08590 ENOG4108IQI permease FOC09_RS08595 ENOG4105E2S oxidase) subunit II FOC09_RS08600 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC09_RS08640 ENOG4105C7N Xanthine uracil vitamin C permease FOC09_RS08645 ENOG4105C85 amino acid FOC09_RS08665 ENOG4105DUX Transporter FOC09_RS08675 ENOG4107D63 FOC09_RS08680 ENOG4105VZ8 Transcriptional regulator FOC09_RS08685 ENOG41069ER domain protein FOC09_RS08690 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC09_RS08695 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC09_RS08755 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC09_RS08760 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC09_RS08765 ENOG4105CNN ABC, transporter FOC09_RS08770 ENOG4105C2J ABC transporter FOC09_RS08780 ENOG4108RVA ribokinase FOC09_RS08785 ENOG4105ETE Transcriptional regulator (LacI family FOC09_RS08795 ENOG41067TZ transcriptional regulator, MarR family FOC09_RS08800 ENOG4105CXY transporter FOC09_RS08810 ENOG4108JQ7 (ABC) transporter FOC09_RS08815 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC09_RS08825 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC09_RS08835 ENOG41068KF Universal stress protein FOC09_RS08840 ENOG4105CHH sulfate transporter FOC09_RS08855 ENOG4105BZU Histidine kinase FOC09_RS08860 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC09_RS08865 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC09_RS08890 ENOG4108IQI permease FOC09_RS08895 ENOG4105DRP amino acid AbC transporter FOC09_RS08900 ENOG4105EAD ABC transporter FOC09_RS08905 ENOG4105CT1 (ABC) transporter FOC09_RS08910 ENOG4105CDA abc transporter atp-binding protein FOC09_RS08915 ENOG4105BZG amino acid carrier protein FOC09_RS08920 ENOG4105CRN Aminoglycoside phosphotransferase FOC09_RS08930 ENOG4105E1K spore germination protein FOC09_RS08945 ENOG4105CG3 alpha amylase, catalytic region FOC09_RS08950 ENOG4105C5Y PTS System FOC09_RS08955 ENOG4107414 GntR family transcriptional regulator FOC09_RS08960 ENOG4105D5Q Arginine ornithine antiporter FOC09_RS08965 ENOG4105BZU Histidine kinase FOC09_RS08980 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC09_RS08985 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC09_RS08990 ENOG4107T89 von Willebrand factor, type A FOC09_RS09000 ENOG4105EXW epimerase dehydratase FOC09_RS09010 ENOG4105DMQ Methyltransferase FOC09_RS09015 ENOG4105E0A ABC, transporter FOC09_RS09020 ENOG4108IHU transport system permease protein FOC09_RS09025 ENOG4105DQ5 transport system permease protein FOC09_RS09030 ENOG4108MES Periplasmic binding protein FOC09_RS09035 ENOG4105DUX Transporter FOC09_RS09050 ENOG4105DAA L-lactate FOC09_RS09055 ENOG4108IJ0 Aspartate ammonia-lyase FOC09_RS09060 ENOG4105C37 (CBS) domain FOC09_RS09065 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC09_RS09070 ENOG4105D9N nucleoside FOC09_RS09075 ENOG4108KGH TRANSCRIPTIONal FOC09_RS09080 ENOG41073R8 VanW family FOC09_RS09115 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC09_RS09120 ENOG4105C59 p-type ATPase FOC09_RS09130 ENOG4105CUB amino acid FOC09_RS09150 ENOG4108JB9 formate dehydrogenase FOC09_RS09155 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC09_RS09160 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC09_RS09165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_RS09170 ENOG4105BZU Histidine kinase FOC09_RS09180 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC09_RS09185 ENOG4108UZ3 Transporter FOC09_RS09195 ENOG4105C6K Malic enzyme FOC09_RS09205 ENOG4108MRH transcriptional regulatory protein FOC09_RS09230 ENOG4105US7 Histidine kinase FOC09_RS09235 ENOG4108STX response regulator FOC09_RS09240 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC09_RS09245 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC09_RS09250 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC09_RS09255 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC09_RS09260 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC09_RS09265 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC09_RS09285 ENOG4105D4T Citrate transporter FOC09_RS09295 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC09_RS09305 ENOG4105DZ6 Band 7 protein FOC09_RS09320 ENOG4105C94 Transporter FOC09_RS09325 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC09_RS09340 ENOG4105CYN Serine protein kinase FOC09_RS09345 ENOG4105BZU Histidine kinase FOC09_RS09350 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC09_RS09360 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC09_RS09370 ENOG4107ZQN disulfide bond FOC09_RS09375 ENOG4108JQC penicillin-binding protein 1A FOC09_RS09490 ENOG4105G5W regulator Fur family FOC09_RS09495 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC09_RS09515 ENOG4108IUW ABC transporter FOC09_RS09525 ENOG4105CBC glutamate synthase FOC09_RS09530 ENOG4107NBY Membrane FOC09_RS09535 ENOG4105BZ1 (ABC) transporter FOC09_RS09555 ENOG4106BXE FOC09_RS09560 ENOG4105CEN a g-specific adenine glycosylase FOC09_RS09565 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC09_RS09595 ENOG4105ECP epimerase FOC09_RS09600 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC09_RS09620 ENOG4105F1A Pyruvate formate-lyase FOC09_RS09640 ENOG4105C3I Nad-dependent epimerase dehydratase FOC09_RS09645 ENOG4107QQG Dehydrogenase FOC09_RS09655 ENOG4105CKK Glycosyl transferase, family 2 FOC09_RS09670 ENOG4108A04 Beta-lactamase FOC09_RS09680 ENOG4105CSV Glutaminase FOC09_RS09705 ENOG4108IQI permease FOC09_RS09715 ENOG4108JUB Transcriptional regulator FOC09_RS09725 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC09_RS09980 ENOG4108IMY Transcriptional regulator FOC09_RS09985 ENOG4105VTR Integrase FOC09_RS09990 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC09_RS10030 ENOG4105UPD Calcium Proton FOC09_RS10035 ENOG410606W general stress protein FOC09_RS10050 ENOG4107ZTW SNARE associated Golgi FOC09_RS10070 ENOG4108IPJ Membrane FOC09_RS10075 ENOG4105C59 p-type ATPase FOC09_RS10080 ENOG4107U9T Pfam:Ribonuclease_BN FOC09_RS10090 ENOG4105KJF protein tyrosine phosphatase FOC09_RS10110 ENOG4108TTB tellurium resistance protein FOC09_RS10115 ENOG4107TS3 membrane protein, TerC FOC09_RS10120 ENOG4106FN3 tellurium resistance protein FOC09_RS10125 ENOG4106FN3 tellurium resistance protein FOC09_RS10130 ENOG4108N0M stress protein FOC09_RS10145 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) FOC09_RS10160 ENOG4105DEU major facilitator superfamily FOC09_RS10180 ENOG41062JF Transcriptional regulator FOC09_RS10205 ENOG4105C5H ABC transporter FOC09_RS10220 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC09_RS10235 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC09_RS10265 ENOG4105CI1 PTS System FOC09_RS10275 ENOG4105C8Q Methyl-accepting chemotaxis FOC09_RS10280 ENOG4105C8Q Methyl-accepting chemotaxis FOC09_RS10290 ENOG4105EAB amino acid AbC transporter FOC09_RS10295 ENOG4105E5Q amino acid AbC transporter FOC09_RS10310 ENOG4105D2S major facilitator superfamily FOC09_RS10315 ENOG410756H nucleotidyltransferase FOC09_RS10335 ENOG4105BZU Histidine kinase FOC09_RS10360 ENOG4106UIA FOC09_RS10365 ENOG4106UIA FOC09_RS10385 ENOG4108V5C ABC transporter FOC09_RS10390 ENOG4105DQ5 transport system permease protein FOC09_RS10395 ENOG4105EHG Permease protein FOC09_RS10400 ENOG4107W7X Aldolase FOC09_RS10410 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FOC09_RS10415 ENOG4105D3R alkyl hydroperoxide reductase FOC09_RS10435 ENOG4105DFD Na H antiporter FOC09_RS10445 ENOG4105DTQ mandelate racemase muconate lactonizing FOC09_RS10460 ENOG4108W15 Protein of unknown function (DUF1456) FOC09_RS10475 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC09_RS10480 ENOG4105D9N nucleoside FOC09_RS10500 ENOG4105KPY Small multidrug resistance protein FOC09_RS10505 ENOG4105C26 Dehydrogenase FOC09_RS10515 ENOG4108JPW Aminotransferase FOC09_RS10520 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC09_RS10525 ENOG4105CBD Diacylglycerol kinase FOC09_RS10550 ENOG410834F Transcriptional regulator FOC09_RS10570 ENOG4105D01 (LipO)protein FOC09_RS10575 ENOG4108UMI ABC transporter, permease FOC09_RS10580 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC09_RS10585 ENOG4108W2Y isochorismatase FOC09_RS10610 ENOG4105C4R Atp-dependent dna helicase FOC09_RS10635 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC09_RS10645 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC09_RS10670 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC09_RS10680 ENOG4105C83 adenylosuccinate lyase FOC09_RS10685 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC09_RS10690 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC09_RS10710 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC09_RS10730 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC09_RS10770 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC09_RS10805 ENOG4105BZU Histidine kinase FOC09_RS10815 ENOG4105C7N Xanthine uracil vitamin C permease FOC09_RS10835 ENOG4108TYN CAAX amino terminal protease family protein FOC09_RS10850 ENOG4105C5H ABC transporter FOC09_RS10855 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC09_RS10860 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC09_RS10865 ENOG41072GX Peptidase M22 Glycoprotease FOC09_RS10870 ENOG4105K8N protein family UPF0079, ATPase FOC09_RS10970 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC09_RS10980 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC09_RS10985 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC09_RS10995 ENOG4107ZXI Rhomboid family FOC09_RS11010 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC09_RS11020 ENOG4108SC4 )-transporter FOC09_RS11030 ENOG4105ERH Fumarylacetoacetate hydrolase FOC09_RS11035 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC09_RS11055 ENOG4108JQ7 (ABC) transporter FOC09_RS11060 ENOG4105C3U ABC transporter FOC09_RS11065 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC09_RS11075 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC09_RS11090 ENOG4105C5H ABC transporter FOC09_RS11110 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC09_RS11115 ENOG4108RE7 deoxyribonuclease FOC09_RS11125 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC09_RS11145 ENOG4105F6E Acyl-transferase FOC09_RS11165 ENOG4105EGI Transcriptional regulator FOC09_RS11175 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC09_RS11185 ENOG4105E0C molybdate abc transporter FOC09_RS11195 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC09_RS11200 ENOG4105II7 pyrroline-5-carboxylate reductase FOC09_RS11210 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC09_RS11215 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC09_RS11245 ENOG4108JQ7 (ABC) transporter FOC09_RS11250 ENOG4105C3U ABC transporter FOC09_RS11255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC09_RS11260 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC09_RS11275 ENOG4105C2C drug resistance transporter, Bcr CflA FOC09_RS11290 ENOG4105IQ5 FAD linked oxidase domain protein FOC09_RS11300 ENOG4105EE1 crotonyl-CoA reductase FOC09_RS11305 ENOG4105D01 (LipO)protein FOC09_RS11310 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC09_RS11315 ENOG4108UMI ABC transporter, permease FOC09_RS11350 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC09_RS11355 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC09_RS11375 ENOG4108VQT Alpha beta hydrolase fold protein FOC09_RS11380 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC09_RS11395 ENOG4107U5W ybbr family FOC09_RS11400 ENOG4105C8B TIGR00159 family FOC09_RS11480 ENOG4108NMV polysaccharide deacetylase FOC09_RS11495 ENOG4105D1F ATP-binding protein FOC09_RS11520 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC09_RS11525 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC09_RS11530 ENOG4108JJB ABC transporter FOC09_RS11560 ENOG41067V7 50S ribosomal protein L36 FOC09_RS11570 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC09_RS11580 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC09_RS11605 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOC09_RS11710 ENOG4105XPM ribosomal protein FOC09_RS11715 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC09_RS11725 ENOG4107Y49 methyltransferase FOC09_RS11750 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC09_RS11765 ENOG4105QIV RNA polymerase FOC09_RS11770 ENOG4105M0M Tetracycline resistance protein FOC09_RS11775 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC09_RS11790 ENOG4105D7W serine acetyltransferase FOC09_RS11810 ENOG4105CTP PilT protein domain protein FOC09_RS11820 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC09_RS11835 ENOG4108Z0C Uvrb UvrC protein FOC09_RS11865 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC09_RS11875 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC09_RS11880 ENOG4105KRF dihydroneopterin aldolase FOC09_RS11885 ENOG4105EEI dihydropteroate synthase FOC09_RS11890 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC09_RS11895 ENOG4105DDQ anthranilate synthase FOC09_RS11900 ENOG4105CRQ synthase (Component I) FOC09_RS11905 ENOG4105C6T cysteine synthase FOC09_RS11920 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC09_RS11925 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC09_RS11930 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC09_RS11950 ENOG41060GV RNA binding s1 domain protein FOC09_RS11965 ENOG4105VYY sporulation protein yabp FOC09_RS11970 ENOG41082I2 s4 domain protein FOC09_RS11975 ENOG4108IY2 MazG family FOC09_RS11985 ENOG4108M14 stage v sporulation protein t FOC09_RS11990 ENOG4108JA2 transcriptioN-repair coupling factor FOC09_RS12000 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC09_RS12005 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC09_RS12020 ENOG4105KME endoribonuclease L-psp FOC09_RS12025 ENOG4105DFT pur operon repressor FOC09_RS12040 ENOG4105W42 Veg protein FOC09_RS12045 ENOG4105XFA sporulation peptidase YabG FOC09_RS12055 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC09_RS12060 ENOG4105F8V Hydrolase, tatD family FOC09_RS12070 ENOG4105KRN Transcriptional regulator, abrb family FOC09_RS12075 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC09_RS12085 ENOG41060K3 Methyltransferase FOC09_RS12095 ENOG4105MA4 psp1 domain protein FOC09_RS12100 ENOG4105FA2 dna polymerase iii FOC09_RS12110 ENOG4105CXN decarboxylase FOC09_RS12145 ENOG41067KS pro-sigma K processing FOC09_RS12165 ENOG4105C6E dna polymerase iii FOC09_RS12175 ENOG4108Z6B deaminase FOC09_RS12180 ENOG4105GTG Isochorismatase FOC09_RS12190 ENOG4105ZMH deoxynucleoside kinase FOC09_RS12225 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC09_RS12260 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC09_RS12275 ENOG410848D S4 domain protein YaaA FOC09_RS12280 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC09_RS12300 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC09_RS12310 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC09_RS12330 ENOG4107QJE Chromosome Partitioning Protein FOC09_RS12335 ENOG4105FA0 parb-like partition protein FOC09_RS12340 ENOG4108ZDA Sporulation protein YyaC FOC09_RS12345 ENOG4105D8X mechanosensitive ion channel FOC09_RS12350 ENOG4105VDK protein, conserved in bacteria FOC09_RS12355 ENOG4105C3G gtp-binding protein FOC09_RS12365 ENOG4108UUM single-stranded DNA-binding protein FOC09_RS12375 ENOG4108XMW Membrane FOC09_RS12380 ENOG4105BZR domain protein FOC09_RS12390 ENOG4105CDU Replicative dna helicase FOC09_RS12420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_RS12425 ENOG4105BZU Histidine kinase FOC09_RS12440 ENOG4105Q2H domain protein FOC09_RS12445 ENOG4105C0H protease FOC09_RS12465 ENOG4105DPN Oligoendopeptidase f FOC09_RS12480 ENOG4105C1J atp-dependent rna helicase FOC09_RS12490 ENOG4108UT2 hemolysin iii FOC09_RS12495 ENOG4105CMR udp-glucose 4-epimerase FOC09_RS12505 ENOG4105IW1 AmiS UreI transporter FOC09_RS12515 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC09_RS12530 ENOG4107RGD Major Facilitator superfamily FOC09_RS12535 ENOG4108HRK Histidine kinase FOC09_RS12540 ENOG4105DY9 regulatoR FOC09_RS12555 ENOG4106F5Q Membrane FOC09_RS12560 ENOG4105E0X reductase FOC09_RS12570 ENOG41067SE Tetr family transcriptional regulator FOC09_RS12575 ENOG4105CKK Glycosyl transferase, family 2 FOC09_RS12595 ENOG4105C5H ABC transporter FOC09_RS12600 ENOG4105JEU Glycosyl transferase, family 2 FOC09_RS12610 ENOG4108S4H thioesterase Superfamily protein FOC09_RS12620 ENOG4106YBV Methyl-accepting chemotaxis FOC09_RS12625 ENOG4105EN6 Membrane FOC09_RS12645 ENOG41079KZ Major Facilitator Superfamily FOC09_RS12650 ENOG4105DY9 regulatoR FOC09_RS12655 ENOG4105D22 carbon starvation protein FOC09_RS12660 ENOG4105VCD cytoplasmic protein FOC09_RS12665 ENOG4105BZU Histidine kinase FOC09_RS12670 ENOG4105DWF phosphomethylpyrimidine kinase FOC09_RS12680 ENOG4105WH1 Two component transcriptional regulator luxr family FOC09_RS12690 ENOG4108Y4K DNA-binding transcriptional activator FOC09_RS12715 ENOG4105D6E homoserine dehydrogenase FOC09_RS12730 ENOG41090WU lipolytic protein G-D-S-L family FOC09_RS12735 ENOG4105CJ1 ABC, transporter FOC09_RS12740 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC09_RS12750 ENOG4105VCH membrane FOC09_RS12755 ENOG410667J hydrolase FOC09_RS12785 ENOG4108VKI Cell wall hydrolase FOC09_RS12800 ENOG4108IJ2 phosphate acetyltransferase FOC09_RS12815 ENOG4108VCI transcription factor, rsfa family FOC09_RS12830 ENOG4105EHG Permease protein FOC09_RS12835 ENOG4105E0A ABC, transporter FOC09_RS12840 ENOG4108MES Periplasmic binding protein FOC09_RS12845 ENOG4105DCI Phosphohydrolase FOC09_RS12850 ENOG41069HH 4-oxalocrotonate tautomerase FOC09_RS12855 ENOG4108Z4T Peptidase M50 FOC09_RS12860 ENOG4108XFG YwhD family FOC09_RS12865 ENOG4105BZ4 penicillin-binding protein FOC09_RS12870 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC09_RS12875 ENOG4107SWG transcriptional regulator MERR family FOC09_RS12880 ENOG4105DXB Major Facilitator superfamily FOC09_RS12890 ENOG4105CYW agmatinase FOC09_RS12910 ENOG410684U Domain of unknown function (DUF1934) FOC09_RS12920 ENOG4105EMN RNA polymerase sigma factor FOC09_RS12940 ENOG4105IIU Aminopeptidase FOC09_RS12950 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC09_RS12955 ENOG4108M15 ABC transporter FOC09_RS12960 ENOG4105KCT ABC transporter FOC09_RS12965 ENOG4105BZU Histidine kinase FOC09_RS12995 ENOG4105BZU Histidine kinase FOC09_RS13010 ENOG4105DF6 Fe-S oxidoreductase FOC09_RS13020 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC09_RS13025 ENOG4105C1G acyl-Coa dehydrogenase FOC09_RS13030 ENOG4105C1G acyl-Coa dehydrogenase FOC09_RS13065 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC09_RS13070 ENOG4105CBT Fructose-1,6-bisphosphatase FOC09_RS13075 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC09_RS13090 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC09_RS13095 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC09_RS13100 ENOG4108ZXQ stage ii sporulation protein r FOC09_RS13110 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC09_RS13125 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC09_RS13130 ENOG4108VGI doxx family FOC09_RS13145 ENOG4108YZG isomerase FOC09_RS13175 ENOG41062M3 atp synthase FOC09_RS13180 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC09_RS13230 ENOG4105BZU Histidine kinase FOC09_RS13235 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC09_RS13245 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC09_RS13250 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC09_RS13275 ENOG4105D65 subunit l FOC09_RS13280 ENOG4105C8S subunit m FOC09_RS13285 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC09_RS13290 ENOG4106778 Protein of unknown function (DUF1146) FOC09_RS13310 ENOG4108IUW ABC transporter FOC09_RS13315 ENOG4105DY9 regulatoR FOC09_RS13330 ENOG4105FRN stage II sporulation protein FOC09_RS13345 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC09_RS13400 ENOG4105EY8 ABC transporter FOC09_RS13405 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC09_RS13420 ENOG4105CMR udp-glucose 4-epimerase FOC09_RS13425 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_RS13430 ENOG4105BZU Histidine kinase FOC09_RS13445 ENOG4105CXY transporter FOC09_RS13465 ENOG4105C19 ABC transporter FOC09_RS13470 ENOG4107RBB ABC transporter, permease FOC09_RS13480 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC09_RS13510 ENOG4105C0D helicase FOC09_RS13515 ENOG4105KBK Zinc finger, swim domain protein FOC09_RS13540 ENOG41069ER domain protein FOC09_RS13545 ENOG4105C94 Transporter FOC09_RS13575 ENOG4105E0M Sulfatase FOC09_RS13585 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC09_RS13595 ENOG4105DAA L-lactate FOC09_RS13635 ENOG4107RSM transcriptional regulator FOC09_RS13640 ENOG4105ECB domain protein FOC09_RS13645 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOC09_RS13660 ENOG4105VZJ PTS System FOC09_RS13670 ENOG4105VCP PTS System FOC09_RS13675 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC09_RS13680 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC09_RS13690 ENOG4105CK1 PTS System FOC09_RS13695 ENOG4105VCP PTS System FOC09_RS13700 ENOG4105F8D glycoside hydrolase family 4 FOC09_RS13705 ENOG410901P UPF0249 protein FOC09_RS13720 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC09_RS13730 ENOG4105ESV Glycosyl transferase, family 4 FOC09_RS13735 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC09_RS13740 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC09_RS13745 ENOG4108KGH TRANSCRIPTIONal FOC09_RS13750 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC09_RS13760 ENOG4105KVH Transcriptional regulator FOC09_RS13775 ENOG41081UC Inherit from COG: Competence protein FOC09_RS13780 ENOG4105VEQ Cold shock protein FOC09_RS13785 ENOG4105MS2 ribosomal subunit Interface protein FOC09_RS13790 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC09_RS13810 ENOG4105CAK Cell division ATP-binding protein ftsE FOC09_RS13815 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC09_RS13820 ENOG4105CN1 protease FOC09_RS13830 ENOG4105BZ1 (ABC) transporter FOC09_RS13845 ENOG4108WS4 fmn reductase FOC09_RS13855 ENOG4105DUM transcriptional regulator, lysR family FOC09_RS13860 ENOG4105HMI Membrane FOC09_RS13885 ENOG4107TXC Transcriptional regulator FOC09_RS13900 ENOG4105D7V transposase FOC09_RS13905 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC09_RS13910 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC09_RS13920 ENOG41086DT Membrane protein of unknown function FOC09_RS13940 ENOG4108S4C acetyltransferase FOC09_RS13950 ENOG4105C3M thioredoxin reductase FOC09_RS13960 ENOG4108Z4K mutator MutT protein FOC09_RS13970 ENOG4105CHW UPF0052 protein FOC09_RS13980 ENOG4105KRI phosphocarrier protein (HPr FOC09_RS13985 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC09_RS13990 ENOG4105H67 Protein of unknown function (DUF421) FOC09_RS14005 ENOG4105CZ3 stage V sporulation protein ad FOC09_RS14010 ENOG41090VF Stage v sporulation protein ac FOC09_RS14030 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC09_RS14055 ENOG4105CP7 Triose-phosphate isomerase FOC09_RS14060 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC09_RS14070 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC09_RS14095 ENOG4105EFC phage portal protein HK97 family FOC09_RS14190 ENOG41067MG lrgb family FOC09_RS14195 ENOG4105XZU Preprotein translocase, subunit SecG FOC09_RS14205 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC09_RS14235 ENOG4105CM4 permease protein FOC09_RS14240 ENOG4108IPW abc transporter atp-binding protein FOC09_RS14255 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FOC09_RS14260 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC09_RS14275 ENOG4105WMR Protein CrcB homolog FOC09_RS14280 ENOG4105WMR Protein CrcB homolog FOC09_RS14290 ENOG4105C8Q Methyl-accepting chemotaxis FOC09_RS14300 ENOG4105D4A Cell wall formation (By similarity) FOC09_RS14305 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC09_RS14320 ENOG4105KVH Transcriptional regulator FOC09_RS14325 ENOG4105F27 Major Facilitator FOC09_RS14330 ENOG4105CV8 reductase FOC09_RS14345 ENOG4108RYK Nad-dependent epimerase dehydratase FOC09_RS14360 ENOG4105D9N nucleoside FOC09_RS14365 ENOG4105D9N nucleoside FOC09_RS14385 ENOG4108URH decarboxylase FOC09_RS14400 ENOG4108RMU ferritin dps family protein FOC09_RS14410 ENOG4105NCW Trka-c domain protein FOC09_RS14415 ENOG4107S91 Sodium hydrogen exchanger FOC09_RS14435 ENOG4105D4Y metalloprotease FOC09_RS14440 ENOG4105VG1 fes assembly suf system protein FOC09_RS14455 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC09_RS14465 ENOG4105BZU Histidine kinase FOC09_RS14470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_RS14475 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC09_RS14485 ENOG4107ZTW SNARE associated Golgi FOC09_RS14520 ENOG4107AYK membrAne FOC09_RS14530 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC09_RS14540 ENOG4107R7I amino acid FOC09_RS14545 ENOG4108SUT Major Facilitator Superfamily FOC09_RS14560 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC09_RS14580 ENOG4105DZ1 carboxypeptidase FOC09_RS14595 ENOG4105CHU acetyl-coa acetyltransferase FOC09_RS14600 ENOG4105C1G acyl-Coa dehydrogenase FOC09_RS14605 ENOG4108W8B Beta-lactamase domain protein FOC09_RS14630 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC09_RS14675 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC09_RS14710 ENOG4108UMI ABC transporter, permease FOC09_RS14715 ENOG4105D01 (LipO)protein FOC09_RS14720 ENOG4105D01 (LipO)protein FOC09_RS14725 ENOG4105C3K feS assembly ATPase SufC FOC09_RS14730 ENOG4105JRK feS assembly protein SufD FOC09_RS14735 ENOG4105C9B Cysteine desulfurase FOC09_RS14740 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC09_RS14745 ENOG4105DIW FeS assembly protein SUFB FOC09_RS14760 ENOG4107R8B 5'-nucleotidase FOC09_RS14765 ENOG4105KZD Domain of unknown function (DUF1805) FOC09_RS14775 ENOG4105FAA peptidase M23 FOC09_RS14800 ENOG41090T1 Membrane FOC09_RS14805 ENOG4107TXC Transcriptional regulator FOC09_RS14810 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC09_RS14815 ENOG4105MMD transcriptional regulator FOC09_RS14830 ENOG4105CBT Fructose-1,6-bisphosphatase FOC09_RS14845 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC09_RS14850 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC09_RS14860 ENOG4108W5N phosphatidylglycerophosphatase a FOC09_RS14875 ENOG41083MR nifu domain-containing protein FOC09_RS14920 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC09_RS14925 ENOG4105C4B ABC transporter, permease FOC09_RS14930 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC09_RS14955 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC09_RS14975 ENOG4105EWC Purine nucleoside phosphorylase FOC09_RS15005 ENOG4105CEP NADH dehydrogenase FOC09_RS15020 ENOG41069ER domain protein FOC09_RS15040 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC09_RS15060 ENOG4105KA0 thioesterase Superfamily protein FOC09_RS15065 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FOC09_RS15080 ENOG4107R3E Citrate transporter FOC09_RS15090 ENOG4105Y38 Kinase-associated protein B FOC09_RS15100 ENOG4105C87 Aminotransferase class I and II FOC09_RS15110 ENOG4108MUZ hydrolase FOC09_RS15115 ENOG4105C5I Dehydrogenase FOC09_RS15120 ENOG4108ZB6 transcriptional regulator AsnC family FOC09_RS15125 ENOG4105CHM Aminotransferase FOC09_RS15135 ENOG4105WG9 Conserved Protein FOC09_RS15140 ENOG4107QYV phosphohexose isomerase FOC09_RS15150 ENOG4107PBV potassium channel FOC09_RS15155 ENOG4105KT7 mgtC SapB transporter FOC09_RS15190 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC09_RS15285 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC09_RS15305 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOC09_RS15315 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOC09_RS15335 ENOG4105VEQ Cold shock protein FOC09_RS15345 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC09_RS15350 ENOG4105E4F Isochorismate synthase FOC09_RS15355 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOC09_RS15360 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC09_RS15365 ENOG4108IPT Naphthoate synthase FOC09_RS15375 ENOG4105DTQ mandelate racemase muconate lactonizing FOC09_RS15405 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC09_RS15425 ENOG4105FDP GntR family transcriptional regulator FOC09_RS15430 ENOG4105C6Z Gluconate FOC09_RS15470 ENOG41086D8 Transcriptional regulator FOC09_RS15475 ENOG4105C19 ABC transporter FOC09_RS15490 ENOG4107ZTW SNARE associated Golgi FOC09_RS15525 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC09_RS15530 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC09_RS15555 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_RS15560 ENOG4105BZU Histidine kinase FOC09_RS15595 ENOG41087YS Phage shock protein A FOC09_RS15640 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC09_RS15645 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC09_RS15650 ENOG4108V2W Carbonate dehydratase FOC09_RS15705 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC09_RS15715 ENOG4105D2X ABC transporter substrate-binding protein FOC09_RS15735 ENOG4107S9D Alpha beta hydrolase FOC09_RS15740 ENOG4105BZU Histidine kinase FOC09_RS15745 ENOG4105BZU Histidine kinase FOC09_RS15750 ENOG4105EGD dinuclear metal center protein, YbgI family FOC09_RS15800 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC09_RS15810 ENOG4105BZF Glycosyl transferase (Group 1 FOC09_RS15815 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC09_RS15820 ENOG4108Z0R Transferase FOC09_RS15825 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC09_RS15855 ENOG4105DA5 (ABC) transporter FOC09_RS15865 ENOG4105N5T Radical SAM Protein FOC09_RS15885 ENOG4105C19 ABC transporter FOC09_RS15900 ENOG4105NCW Trka-c domain protein FOC09_RS15905 ENOG4107S91 Sodium hydrogen exchanger FOC09_RS15910 ENOG410605W Major Facilitator FOC09_RS15940 ENOG4108B31 Spore germination protein FOC09_RS15950 ENOG4105DWV Homoserine O-trans-acetylase FOC09_RS15960 ENOG41085GJ domain protein FOC09_RS15985 ENOG4105D06 uba thif-type nad fad binding protein FOC09_RS15995 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC09_RS16000 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC09_RS16005 ENOG4108ZAF Molybdopterin FOC09_RS16020 ENOG4105CSC Glucose uptake protein FOC09_RS16025 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC09_RS16030 ENOG4108VJ1 Transcriptional regulator (CarD family FOC09_RS16065 ENOG4105CBX hi0933 family FOC09_RS16080 ENOG4105YW5 deoR family transcriptional regulator FOC09_RS16095 ENOG4108IUM Glycogen debranching enzyme FOC09_RS16100 ENOG4108V15 phosphotransferase enzyme family FOC09_RS16115 ENOG4105C8F Beta-lactamase domain protein FOC09_RS16145 ENOG4108VDD TRNA binding domain protein FOC09_RS16190 ENOG4105C88 aminopeptidase FOC09_RS16210 ENOG4105ETE Transcriptional regulator (LacI family FOC09_RS16240 ENOG4105EP9 oxidoreductase FOC09_RS16245 ENOG4107SNB ankyrin repeat protein YahD FOC09_RS16255 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC09_RS16265 ENOG4105DGU Histone deacetylase FOC09_RS16270 ENOG4105W87 Cbs domain FOC09_RS16275 ENOG4105F1V Acetoin utilization protein FOC09_RS16295 ENOG4105EMN RNA polymerase sigma factor FOC09_RS16305 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC09_RS16325 ENOG4105C28 cystathionine FOC09_RS16345 ENOG4106KR7 LysR family Transcriptional regulator FOC09_RS16370 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC09_RS16380 ENOG4105EFZ amidohydrolase FOC09_RS16395 ENOG4105KBJ sporulation protein ytfj FOC09_RS16400 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC09_RS16410 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC09_RS16430 ENOG4108JYZ YitT family FOC09_RS16470 ENOG4107YZX Universal stress protein FOC09_RS16490 ENOG4105VZ8 Transcriptional regulator FOC09_RS16500 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC09_RS16505 ENOG4105Z7P Acetyltransferase (GNAT) family FOC09_RS16540 ENOG4105DC7 peptidase M24 FOC09_RS16575 ENOG4105SFS phosphoesterase RecJ domain protein FOC09_RS16585 ENOG4105VV2 FOC09_RS16590 ENOG4105C0B DNA polymerase III (alpha subunit) FOC09_RS16595 ENOG4105C6K Malic enzyme FOC09_RS16600 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC09_RS16625 ENOG4105FS0 cytoplasmic membrane protein FOC09_RS16630 ENOG4108REF Sporulation integral membrane protein ytvi FOC09_RS16640 ENOG4105BZN citrate synthase FOC09_RS16645 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC09_RS16660 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC09_RS16665 ENOG4105BZU Histidine kinase FOC09_RS16670 ENOG4105C2M dna polymerase I FOC09_RS16675 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC09_RS16685 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC09_RS16690 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC09_RS16700 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC09_RS16720 ENOG4108TDW sporulation protein YtxC FOC09_RS16725 ENOG4105C22 threonyL-tRNA synthetase FOC09_RS16730 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC09_RS16750 ENOG4105CN9 Peptidase m42 family protein FOC09_RS16755 ENOG4108JGH Tetr family transcriptional regulator FOC09_RS16760 ENOG4105CW7 secretion protein, HlyD family FOC09_RS16765 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC09_RS16800 ENOG4108RWN rrna methyltransferase FOC09_RS16810 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC09_RS16815 ENOG4105C5S asparaginyl-tRNA synthetase FOC09_RS16850 ENOG4105DCG PHP domain protein FOC09_RS16860 ENOG4105FE9 pseudouridine synthase FOC09_RS16870 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC09_RS16880 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC09_RS16895 ENOG4105E0A ABC, transporter FOC09_RS16900 ENOG4105KFN sortase, SrtB family FOC09_RS16915 ENOG4105DR4 Methyltransferase FOC09_RS16925 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC09_RS16965 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC09_RS16970 ENOG4105J76 Periplasmic binding protein FOC09_RS16980 ENOG4105CEY Amp-dependent synthetase and ligase FOC09_RS16985 ENOG4107Z3H Transcriptional regulator, TetR family FOC09_RS16990 ENOG41060WC Enoyl-CoA hydratase FOC09_RS16995 ENOG4105BZJ Electron transfer flavoprotein FOC09_RS17000 ENOG4105C10 Electron transfer flavoprotein FOC09_RS17005 ENOG4105K63 Thioredoxin FOC09_RS17020 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC09_RS17030 ENOG4105E33 succinate dehydrogenase FOC09_RS17040 ENOG4108VXD carboxy-peptidase FOC09_RS17045 ENOG4105E14 MotA TolQ exbB proton channel FOC09_RS17055 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC09_RS17060 ENOG4108IUX (ABC) transporter FOC09_RS17065 ENOG4105RHA ABC transporter, permease FOC09_RS17070 ENOG4108Z40 Transcriptional regulator FOC09_RS17075 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC09_RS17085 ENOG4108JCI Transcriptional regulator FOC09_RS17090 ENOG41067S9 phage shock protein C, PspC FOC09_RS17105 ENOG4105DY9 regulatoR FOC09_RS17115 ENOG4108JQ7 (ABC) transporter FOC09_RS17130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC09_RS17135 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC09_RS17140 ENOG4105DZC cytosine deaminase FOC09_RS17145 ENOG4105DZC cytosine deaminase FOC09_RS17160 ENOG4105PFC Transcriptional regulator FOC09_RS17175 ENOG4105KBX Transcriptional regulator, TetR family FOC09_RS17185 ENOG4108PCX Major Facilitator FOC09_RS17195 ENOG4108XJQ germination protein FOC09_RS17205 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOC09_RS17210 ENOG4105M59 Phosphodiesterase, mj0936 family FOC09_RS17230 ENOG4108QCI YvbH-like oligomerisation region FOC09_RS17255 ENOG4108IUQ atp-dependent protease FOC09_RS17275 ENOG4105K56 Transcriptional regulator FOC09_RS17300 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC09_RS17310 ENOG41068KH stage VI sporulation protein D FOC09_RS17320 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC09_RS17325 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC09_RS17345 ENOG4105DFF Rod shape-determining protein mreb FOC09_RS17350 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOC09_RS17365 ENOG4107QMS site-determining protein FOC09_RS17380 ENOG4105C03 ribonuclease FOC09_RS17390 ENOG4105X36 (ribosomal) protein FOC09_RS17405 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC09_RS17435 ENOG4105CQC Prephenate dehydratase FOC09_RS17440 ENOG4108RPX mosc domain containing protein FOC09_RS17455 ENOG4108IYU L-aspartate oxidase FOC09_RS17460 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC09_RS17485 ENOG41082BM Transcriptional regulator, arsr family FOC09_RS17490 ENOG4108IPJ Membrane FOC09_RS17495 ENOG4108IPJ Membrane FOC09_RS17505 ENOG4108HUF Transporter FOC09_RS17520 ENOG41061AI Protein of unknown function (DUF2905) FOC09_RS17535 ENOG4105VIE preprotein translocase, subunit YajC FOC09_RS17545 ENOG4108QG2 Membrane FOC09_RS17550 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC09_RS17560 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC09_RS17565 ENOG41076HS cation diffusion facilitator family transporter FOC09_RS17570 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC09_RS17580 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC09_RS17590 ENOG4105CUT histidyl-tRNA synthetase FOC09_RS17600 ENOG4105CUZ uba thif-type nad fad binding protein FOC09_RS17605 ENOG4108VCI transcription factor, rsfa family FOC09_RS17610 ENOG4105D1H recombination factor protein RarA FOC09_RS17620 ENOG4105C3J Cysteine desulfurase FOC09_RS17625 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC09_RS17635 ENOG4105C7H Helicase, RecD TraA family FOC09_RS17640 ENOG41060CR FOC09_RS17655 ENOG4105C02 permease FOC09_RS17665 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC09_RS17685 ENOG4105HHA aminodeoxychorismate lyase FOC09_RS17690 ENOG4108VQJ O-methyltransferase FOC09_RS17695 ENOG4105XYU peptidase (U32 family) FOC09_RS17700 ENOG4105CFP Peptidase U32 FOC09_RS17715 ENOG4107XRG penicillin-binding protein FOC09_RS17745 ENOG4105C28 cystathionine FOC09_RS17750 ENOG4108EKI Dehydrogenase FOC09_RS17760 ENOG4108V5C ABC transporter FOC09_RS17765 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC09_RS17815 ENOG4105MIR Phenylalanine 4-monooxygenase FOC09_RS17820 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC09_RS17855 ENOG4108MUZ hydrolase FOC09_RS17865 ENOG4105G6Z alkaline phosphatase FOC09_RS17880 ENOG4108TVJ Nitroreductase FOC09_RS17900 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC09_RS17915 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC09_RS17920 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC09_RS17930 ENOG410812S Rna-binding protein FOC09_RS17940 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC09_RS17950 ENOG4105DXX methyltransferase FOC09_RS17960 ENOG4105KQC Competence protein FOC09_RS17965 ENOG4108UK2 deaminase FOC09_RS17970 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC09_RS17980 ENOG4105TQK DNA polymerase iii, delta' subunit FOC09_RS18005 ENOG4105KVH Transcriptional regulator FOC09_RS18010 ENOG4105CSA Coproporphyrinogen iii oxidase FOC09_RS18020 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOC09_RS18040 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC09_RS18045 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC09_RS18055 ENOG4105KTH gatB Yqey FOC09_RS18060 ENOG41068P3 sporulation protein YqfC FOC09_RS18070 ENOG4105C9A Phoh family FOC09_RS18075 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC09_RS18085 ENOG4107YR5 Diacylglycerol kinase FOC09_RS18090 ENOG4105KG3 cytidine deaminase FOC09_RS18095 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC09_RS18120 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC09_RS18125 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC09_RS18140 ENOG4105EGD dinuclear metal center protein, YbgI family FOC09_RS18165 ENOG41069ZM Protein of unknown function (DUF2624) FOC09_RS18170 ENOG4108JYZ YitT family FOC09_RS18175 ENOG4105FDK ABC transporter FOC09_RS18185 ENOG4105N80 Ferric uptake regulator, Fur family FOC09_RS18210 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC09_RS18220 ENOG4107RF6 penicillin-binding protein FOC09_RS18225 ENOG4105PWN phosphate abc transporter FOC09_RS18230 ENOG4105C8U phosphate abc transporter FOC09_RS18235 ENOG4105E2Z phosphate ABC transporter (Permease FOC09_RS18240 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC09_RS18245 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC09_RS18260 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC09_RS18270 ENOG4105DKQ ROK family FOC09_RS18280 ENOG4105C5X domain protein FOC09_RS18300 ENOG4105C28 cystathionine FOC09_RS18305 ENOG4105C28 cystathionine FOC09_RS18315 ENOG4105C3R Methionine synthase FOC09_RS18320 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC09_RS18440 ENOG4105C0D helicase FOC09_RS18470 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC09_RS18475 ENOG4105CJ1 ABC, transporter FOC09_RS18510 ENOG41080TC multidrug resistance protein FOC09_RS18530 ENOG4105WZW rhodanese family FOC09_RS18535 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC09_RS18555 ENOG4107YBY Hydrolase FOC09_RS18565 ENOG4105CBJ Metal-dependent enzyme FOC09_RS18580 ENOG4105DC7 peptidase M24 FOC09_RS18605 ENOG4105CD2 stage iii sporulation protein aa FOC09_RS18610 ENOG4105KR5 Stage iii sporulation protein FOC09_RS18615 ENOG4108CQH stage III sporulation protein AC FOC09_RS18620 ENOG4105KQ4 Stage iii sporulation protein ad FOC09_RS18630 ENOG410644B Stage III sporulation protein af FOC09_RS18655 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC09_RS18660 ENOG4108ZSR alkaline shock protein FOC09_RS18685 ENOG4105CTB Polyprenyl synthetase FOC09_RS18695 ENOG4105DX0 Hemolysin A FOC09_RS18705 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC09_RS18710 ENOG4105S1Z Stage IV sporulation protein B FOC09_RS18715 ENOG4107QQR Sporulation FOC09_RS18730 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC09_RS18740 ENOG4108JUB Transcriptional regulator FOC09_RS18750 ENOG4107RDP Dehydrogenase FOC09_RS18770 ENOG4105CPP Dehydrogenase, E1 component FOC09_RS18775 ENOG4105C7S Dehydrogenase FOC09_RS18790 ENOG4105G7B Protein of unknown function (DUF2992) FOC09_RS18800 ENOG4108HW3 (ABC) transporter FOC09_RS18805 ENOG4105E5Q amino acid AbC transporter FOC09_RS18810 ENOG4105CDA abc transporter atp-binding protein FOC09_RS18815 ENOG4108QEG Membrane FOC09_RS18820 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC09_RS18835 ENOG4105D9U N-acetyltransferase FOC09_RS18840 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC09_RS18850 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC09_RS18875 ENOG4105EJQ L-serine dehydratase FOC09_RS18880 ENOG4105II7 pyrroline-5-carboxylate reductase FOC09_RS18890 ENOG4108IXY short-chain dehydrogenase reductase FOC09_RS18905 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC09_RS18945 ENOG4105CGH 5'-nucleotidase FOC09_RS18950 ENOG4105DFD Na H antiporter FOC09_RS18960 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC09_RS18970 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC09_RS18975 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC09_RS18980 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC09_RS18985 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FOC09_RS19005 ENOG4108R6K riboflavin synthase, subunit alpha FOC09_RS19010 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC09_RS19030 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC09_RS19035 ENOG4105ETE Transcriptional regulator (LacI family FOC09_RS19045 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC09_RS19065 ENOG4105RHY Pfam:UPF0157 FOC09_RS19075 ENOG4105CPC Aldo Keto reductase FOC09_RS19095 ENOG4105MZ9 stage II sporulation protein m FOC09_RS19100 ENOG4105I3K Ferric uptake regulator, Fur family FOC09_RS19110 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC09_RS19135 ENOG4105D7N magnesium and cobalt transport protein CorA FOC09_RS19165 ENOG4105DVE abc transporter atp-binding protein FOC09_RS19170 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC09_RS19175 ENOG4105DZ1 carboxypeptidase FOC09_RS19180 ENOG41082AN stage II sporulation protein FOC09_RS19190 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC09_RS19195 ENOG4105C8J )-transporter FOC09_RS19215 ENOG41090VF Stage v sporulation protein ac FOC09_RS19220 ENOG4105CZ3 stage V sporulation protein ad FOC09_RS19230 ENOG4105G6R Stage v sporulation protein ae FOC09_RS19240 ENOG4105J7I hydrolase FOC09_RS19245 ENOG4105PTM secreted protein FOC09_RS19250 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC09_RS19285 ENOG4105CE4 GlcNAc 6-P deacetylase FOC09_RS19295 ENOG4105FDP GntR family transcriptional regulator FOC09_RS19305 ENOG4105CID antiterminator FOC09_RS19320 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC09_RS19340 ENOG4106TD9 Diguanylate cyclase FOC09_RS19360 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOC09_RS19385 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC09_RS19395 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FOC09_RS19405 ENOG4105DTD Dehydrogenase FOC09_RS19410 ENOG4105K7K Transcriptional regulator FOC09_RS19450 ENOG4105CHU acetyl-coa acetyltransferase FOC09_RS19495 ENOG4105CG3 alpha amylase, catalytic region FOC09_RS19505 ENOG4107FKK extracellular solute-binding protein family 1 FOC09_RS19515 ENOG4105EG2 ABC transporter, permease FOC09_RS19520 ENOG4105FKQ transcriptional regulator FOC09_RS19525 ENOG4105CHM Aminotransferase FOC09_RS19535 ENOG4108HGU Histidine kinase FOC09_RS19590 ENOG4105UIN FOC09_RS19600 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC09_RS19615 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC09_RS19620 ENOG4105EPM Diguanylate phosphodiesterase FOC09_RS19635 ENOG4107IN1 Protein of unknown function (DUF1797) FOC09_RS19640 ENOG4108XRC Protein of unknown function (DUF458) FOC09_RS19675 ENOG4107ZYR domain protein FOC09_RS19680 ENOG4105CN5 Metallo-Beta-Lactamase FOC09_RS19690 ENOG4108X4Q Hydrolase FOC09_RS19695 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC09_RS19710 ENOG4105CPP Dehydrogenase, E1 component FOC09_RS19715 ENOG4105C7S Dehydrogenase FOC09_RS19760 ENOG4105CXN decarboxylase FOC09_RS19780 ENOG4105ECY inositol monophosphatase FOC09_RS19790 ENOG4105CI3 gtp-binding protein typa FOC09_RS19795 ENOG4105QA2 FOC09_RS19815 ENOG4108IAB Phoh family FOC09_RS19830 ENOG4105CNI cell division protein FtsW FOC09_RS19835 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC09_RS19885 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC09_RS19900 ENOG4107TB6 phosphoglycerate mutase FOC09_RS19920 ENOG4106H78 methyltransferase FOC09_RS19930 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC09_RS19935 ENOG4105D78 K07001 NTE family protein FOC09_RS19940 ENOG41063PX domain protein FOC09_RS19950 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC09_RS19970 ENOG4108IMY Transcriptional regulator FOC09_RS20015 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC09_RS20030 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOC09_RS20115 ENOG4105CAR Terminase, large subunit FOC09_RS20125 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC09_RS20205 ENOG4105XSJ toxin secretion phage lysis holin FOC09_RS20255 ENOG4105KNH Nucleic acid-binding protein FOC09_RS20295 ENOG41068DC Essential cell division protein (By similarity) FOC09_RS20300 ENOG4105CJN penicillin-binding protein FOC09_RS20305 ENOG4105CJN penicillin-binding protein FOC09_RS20310 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC09_RS20325 ENOG4105CNI cell division protein FtsW FOC09_RS20330 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC09_RS20335 ENOG4105D4A Cell wall formation (By similarity) FOC09_RS20340 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC09_RS20345 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC09_RS20350 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC09_RS20360 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC09_RS20370 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC09_RS20375 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC09_RS20380 ENOG4105DFA alanine racemase domain protein FOC09_RS20390 ENOG41067XK integral membrane protein FOC09_RS20395 ENOG4105DBK s4 domain protein FOC09_RS20405 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC09_RS20420 ENOG4105C34 Pseudouridine synthase FOC09_RS20445 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOC09_RS20500 ENOG4105DC7 peptidase M24 FOC09_RS20505 ENOG4105F23 Fibronectin-binding protein FOC09_RS20515 ENOG4105DSJ YicC domain protein FOC09_RS20535 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC09_RS20540 ENOG4105C25 Primosomal protein n' FOC09_RS20545 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC09_RS20555 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC09_RS20565 ENOG4108ZF3 Phosphatase FOC09_RS20570 ENOG4105D9P serine threonine protein kinase FOC09_RS20575 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC09_RS20580 ENOG4105DJV ribulose-phosphate 3-epimerase FOC09_RS20585 ENOG4105FJ0 thiamine FOC09_RS20600 ENOG4108ZAA Alkaline-shock protein FOC09_RS20605 ENOG4105DP4 dak2 domain fusion protein ylov FOC09_RS20610 ENOG4105CB5 ATP-dependent DNA helicase recG FOC09_RS20625 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC09_RS20630 ENOG4105CHR reductase FOC09_RS20645 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC09_RS20650 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC09_RS20670 ENOG4105VB6 UPF0109 protein FOC09_RS20695 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC09_RS20710 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC09_RS20720 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC09_RS20730 ENOG4108HE4 integrase family FOC09_RS20770 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC09_RS20775 ENOG4105KNE Phosphatidate cytidylyltransferase FOC09_RS20780 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC09_RS20785 ENOG4105DZP Membrane-associated zinc metalloprotease FOC09_RS20795 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC09_RS20805 ENOG4105CHV Transcription elongation factor NusA FOC09_RS20810 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC09_RS20815 ENOG4105VHM ribosomal protein FOC09_RS20825 ENOG4105W7A Protein of unknown function (DUF503) FOC09_RS20835 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC09_RS20840 ENOG4105DTN riboflavin biosynthesis protein ribF FOC09_RS20860 ENOG4105C1V Peptidase, M16 FOC09_RS20870 ENOG4105E35 Dipicolinate synthase subunit A FOC09_RS20875 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC09_RS20880 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC09_RS20890 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC09_RS20900 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC09_RS20910 ENOG4107QZI cell division protein FtsK FOC09_RS20915 ENOG4105FDP GntR family transcriptional regulator FOC09_RS20920 ENOG4105DIH basic membrane FOC09_RS20925 ENOG4108JQ9 ABC transporter FOC09_RS20950 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC09_RS20955 ENOG4105XZV Protein of unknown function (DUF3243) FOC09_RS20970 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC09_RS20995 ENOG4105D48 metallophosphoesterase FOC09_RS21000 ENOG4105MCT stage V sporulation protein S FOC09_RS21005 ENOG4108IGT Dipeptidase FOC09_RS21010 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC09_RS21015 ENOG4105DQU oxidoreductase, subunit beta FOC09_RS21020 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC09_RS21045 ENOG4105DA5 (ABC) transporter FOC09_RS21070 ENOG4107QHE Choloylglycine hydrolase FOC09_RS21080 ENOG410890F Dynamin family FOC09_RS21085 ENOG4105E0M Sulfatase FOC09_RS21090 ENOG4107R6R udp-galactopyranose mutase FOC09_RS21095 ENOG4105F0V Cell wall hydrolase FOC09_RS21120 ENOG4107YEI lmbE family FOC09_RS21125 ENOG4107TTQ Alpha beta hydrolase fold FOC09_RS21140 ENOG41067MG lrgb family FOC09_RS21160 ENOG4105BZU Histidine kinase FOC09_RS21165 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC09_RS21195 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC09_RS21200 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC09_RS21210 ENOG4105CGK Exodeoxyribonuclease III FOC09_RS21230 ENOG4105E0A ABC, transporter FOC09_RS21235 ENOG4105NIV Esterase FOC09_RS21245 ENOG4105VPX protein, conserved in bacteria FOC09_RS21250 ENOG410681U heavy metal transport detoxification protein FOC09_RS21255 ENOG4105C59 p-type ATPase FOC09_RS21260 ENOG4105K70 DNA-binding protein FOC09_RS21265 ENOG4105TMB Formate nitrite transporter FOC09_RS21280 ENOG4105C85 amino acid FOC09_RS21290 ENOG4108SJC Membrane FOC09_RS21300 ENOG4105E98 transcriptional regulator DeoR family FOC09_RS21305 ENOG4105DE4 1-phosphofructokinase FOC09_RS21310 ENOG4105DM4 PTS System FOC09_RS21315 ENOG41069ER domain protein FOC09_RS21345 ENOG4106F1P AAA ATPase, central domain protein FOC09_RS21355 ENOG4105EN6 Membrane FOC09_RS21365 ENOG4105CXI aluminum resistance protein FOC09_RS21370 ENOG4105KV4 Transcriptional regulator FOC09_RS21375 ENOG4105C5F glutamine synthetase FOC09_RS21475 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FOC09_RS21655 ENOG4105XSJ toxin secretion phage lysis holin FOC09_RS21660 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOC09_RS21690 ENOG4105K7K Transcriptional regulator FOC09_RS21710 ENOG4108SVB resolvase FOC09_RS21730 ENOG4105D5T phosphonate abc transporter FOC09_RS21745 ENOG4105D7V transposase FOC09_RS21765 ENOG4105BZ1 (ABC) transporter FOC09_RS21770 ENOG4105BZ1 (ABC) transporter FOC09_RS21785 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC09_RS21810 ENOG41067MG lrgb family FOC09_RS21815 ENOG4105VAW lrga family FOC09_RS21820 ENOG4107RSM transcriptional regulator FOC09_RS21830 ENOG4107QIV Cytochrome c biogenesis protein FOC09_RS21885 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC09_RS21910 ENOG4108903 Formimidoylglutamase FOC09_RS21915 ENOG4108VJ1 Transcriptional regulator (CarD family FOC09_RS21920 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC09_RS21925 ENOG4105CBC glutamate synthase FOC09_RS21930 ENOG4105CK7 Sodium proline symporter FOC09_RS21935 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC09_RS21940 ENOG4105FBA Phospholipase Carboxylesterase FOC09_RS21945 ENOG4105BZU Histidine kinase FOC09_RS21955 ENOG4107AYK membrAne FOC09_RS22005 ENOG4105CEY Amp-dependent synthetase and ligase FOC09_RS22010 ENOG4107ZYJ bioY protein FOC09_RS22015 ENOG4107F3J Amp-dependent synthetase and ligase FOC09_RS22035 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC09_RS22075 ENOG4108I0Z Aconitate hydratase FOC09_RS22080 ENOG4108JJA ABC, transporter FOC09_RS22090 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC09_RS22095 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC09_RS22125 ENOG4105W8X HesB YadR YfhF-family protein FOC09_RS22130 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC09_RS22135 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC09_RS22145 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_RS22150 ENOG4105C0H protease FOC09_RS22155 ENOG4105K4P CoA-binding domain protein FOC09_RS22160 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC09_RS22170 ENOG4105D9R oxidoreductase FOC09_RS22180 ENOG4105CIG ABC transporter FOC09_RS22195 ENOG4105EMN RNA polymerase sigma factor FOC09_RS22205 ENOG4108KGH TRANSCRIPTIONal FOC09_RS22270 ENOG4105E1K spore germination protein FOC09_RS22275 ENOG4108JB9 formate dehydrogenase FOC09_RS22285 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC09_RS22290 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC09_RS22300 ENOG4105TMB Formate nitrite transporter FOC09_RS22305 ENOG4105D06 uba thif-type nad fad binding protein FOC09_RS22310 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC09_RS22315 ENOG4108ZAF Molybdopterin FOC09_RS22325 ENOG4105D1F ATP-binding protein FOC09_RS22340 ENOG410696E Membrane FOC09_RS22345 ENOG4105FR1 rard protein FOC09_RS22355 ENOG4105EWU Squalene--hopene cyclase FOC09_RS22365 ENOG4105CHR reductase FOC09_RS22370 ENOG4105C26 Dehydrogenase FOC09_RS22380 ENOG4108IA2 Sodium pantothenate symporter FOC09_RS22395 ENOG4106IQC argininosuccinate lyase FOC09_RS22405 ENOG410904N short-chain dehydrogenase reductase FOC09_RS22425 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC09_RS22445 ENOG4105VEQ Cold shock protein FOC09_RS22460 ENOG4108R1P FOC09_RS22470 ENOG41073R8 VanW family FOC09_RS22475 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC09_RS22490 ENOG4105KT7 mgtC SapB transporter FOC09_RS22500 ENOG4105E39 Enoyl-CoA hydratase FOC09_RS22505 ENOG4105K64 Glycosyl transferase, family 2 FOC09_RS22515 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC09_RS22535 ENOG4105CQB FAD linked oxidase domain protein FOC09_RS22540 ENOG4105C09 Bile acid FOC09_RS22550 ENOG4105RHY Pfam:UPF0157 FOC09_RS22575 ENOG4105CIS alcohol dehydrogenase FOC09_RS22580 ENOG41082BM Transcriptional regulator, arsr family FOC09_RS22605 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC09_RS22635 ENOG4108A04 Beta-lactamase FOC09_RS22640 ENOG4105DPN Oligoendopeptidase f FOC09_RS22650 ENOG4105E5K Alpha-amylase FOC09_RS22660 ENOG4105C98 muts2 protein FOC09_RS22680 ENOG4107V2S Transcriptional regulator FOC09_RS22690 ENOG4107CUJ Protein of unknown function (DUF2690) FOC09_RS22710 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC09_RS22715 ENOG4105NX3 Membrane FOC09_RS22720 ENOG4105DQ5 transport system permease protein FOC09_RS22725 ENOG4105EHG Permease protein FOC09_RS22730 ENOG4108MES Periplasmic binding protein FOC09_RS22750 ENOG4107R3E Citrate transporter FOC09_RS22760 ENOG4108TN2 lmbE family FOC09_RS22830 ENOG4105H3G oxidoreductase FOC09_RS22840 ENOG4105ED2 Beta-lactamase FOC09_RS22865 ENOG4107YXZ hydrolase, family 25 FOC09_RS22880 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC09_RS22905 ENOG4105KAF membrAne FOC09_RS22975 ENOG4105KVH Transcriptional regulator FOC09_RS22995 ENOG4105CHR reductase FOC09_RS23005 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC09_RS23040 ENOG4105KVH Transcriptional regulator FOC09_RS23045 ENOG4105KVH Transcriptional regulator FOC09_RS23050 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC09_RS23060 ENOG4108TZY GntR Family Transcriptional Regulator FOC09_RS23065 ENOG4105KVH Transcriptional regulator FOC09_RS23095 ENOG4105C44 Serine transporter FOC09_RS23100 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC09_RS23115 ENOG4105F27 Major Facilitator FOC09_RS23120 ENOG4105CV8 reductase FOC09_RS23140 ENOG4105D4Y metalloprotease FOC09_RS23145 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC09_RS23160 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC09_RS23165 ENOG4105CIS alcohol dehydrogenase FOC09_RS23170 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC09_RS23175 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC09_RS23190 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC09_RS23195 ENOG4105C6Z Gluconate FOC09_RS23200 ENOG4105CMG Carbohydrate kinase FOC09_RS23205 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC09_RS23210 ENOG4105XDF Protein of unknown function (DUF1272) FOC09_RS23215 ENOG4105DDN Pentapeptide repeat-containing protein FOC09_RS23230 ENOG4105C37 (CBS) domain FOC09_RS23260 ENOG4105EV4 Multidrug resistance protein mdtH FOC09_RS23270 ENOG4105DMQ Methyltransferase FOC09_RS23290 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC09_RS23295 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC09_RS23300 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC09_RS23310 ENOG4108UW5 maltose o-acetyltransferase FOC09_RS23315 ENOG4106UW1 Major Facilitator superfamily FOC09_RS23320 ENOG4105DKQ ROK family FOC09_RS23325 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC09_RS23385 ENOG4105CJ1 ABC, transporter FOC09_RS23395 ENOG4108PSK reductase FOC09_RS23415 ENOG4108RCM Nitroreductase FOC09_RS23420 ENOG4105KVH Transcriptional regulator FOC09_RS23435 ENOG4105CUT histidyl-tRNA synthetase FOC09_RS23440 ENOG4108Z66 YbaK ebsC protein FOC09_RS23450 ENOG41067QW Transcriptional regulator FOC09_RS23465 ENOG4108K8S endonuclease I FOC09_RS23490 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC09_RS23495 ENOG4108JJB ABC transporter FOC09_RS23525 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC09_RS23535 ENOG4105CRW Short chain fatty acid transporter FOC09_RS23545 ENOG4105KBX Transcriptional regulator, TetR family FOC09_RS23550 ENOG4105KPY Small multidrug resistance protein FOC09_RS23555 ENOG4105RXJ FOC09_RS23565 ENOG41069JR FOC09_RS23570 ENOG4105DA5 (ABC) transporter FOC09_RS23590 ENOG4105CZM Major Facilitator FOC09_RS23595 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC09_RS23605 ENOG4108ISG Major Facilitator FOC09_RS23655 ENOG410874W AraC family transcriptional regulator FOC09_RS23660 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC09_RS23675 ENOG4108AEY RNA polymerase sigma factor FOC09_RS23695 ENOG4108JQ1 Dehydrogenase FOC09_RS23710 ENOG4105DVH amino acid FOC09_RS23720 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC09_RS23735 ENOG4108JPW Aminotransferase FOC09_RS23750 ENOG4105EJQ L-serine dehydratase FOC09_RS23755 ENOG4105C44 Serine transporter FOC09_RS23770 ENOG4108JGH Tetr family transcriptional regulator FOC09_RS23775 ENOG4105EQ0 Major Facilitator superfamily FOC09_RS23795 ENOG4107QJQ Mate efflux family protein FOC09_RS23825 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC09_RS23855 ENOG4105TRI Hydrolase FOC09_RS23885 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC09_RS23895 ENOG4106P55 Transcriptional regulator FOC09_RS23905 ENOG4107QR9 Iron-sulfur cluster binding protein FOC09_RS23910 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FOC09_RS23915 ENOG4105DJB Major Facilitator Superfamily FOC09_RS23920 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC09_RS23935 ENOG4108U05 Transcriptional regulator FOC09_RS23950 ENOG4105BZU Histidine kinase FOC09_RS23965 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC09_RS23970 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC09_RS23985 ENOG4105JQZ Methyltransferase FOC09_RS23990 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC09_RS24000 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC09_RS24005 ENOG4108NNI Beta-lactamase domain-containing protein FOC09_RS24020 ENOG4105VZ8 Transcriptional regulator FOC09_RS24040 ENOG4105K6H D-cysteine desulfhydrase FOC09_RS24065 ENOG41062D9 Histidine kinase FOC09_RS24070 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_RS24085 ENOG4105IIP Membrane FOC09_RS24095 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC09_RS24100 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC09_RS24175 ENOG4108YXU transcriptional regulator AsnC family FOC09_RS24180 ENOG4105CHR reductase FOC09_RS24190 ENOG4105F7F Chaperone FOC09_RS24205 ENOG41085FC arsR family transcriptional regulator FOC09_RS24210 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC09_RS24215 ENOG4105D6J arsenicaL-resistance protein FOC09_RS24245 ENOG4105DIK (ABC) transporter FOC09_RS24250 ENOG4105CC5 ABC transporter FOC09_RS24255 ENOG4105DSE periplasmic solute binding protein FOC09_RS24260 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC09_RS24265 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC09_RS24280 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC09_RS24285 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC09_RS24300 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC09_RS24305 ENOG4108606 TspO/MBR family FOC09_RS24340 ENOG41090MY MarR family Transcriptional regulator FOC09_RS24365 ENOG4105CHJ isochorismatase hydrolase FOC09_RS24375 ENOG4105CH6 catalase FOC09_RS24380 ENOG4105CGH 5'-nucleotidase FOC09_RS24415 ENOG4105CSV Glutaminase FOC09_RS24450 ENOG4105C6K Malic enzyme FOC09_RS24460 ENOG4105II7 pyrroline-5-carboxylate reductase FOC09_RS24470 ENOG4105CUB amino acid FOC09_RS24475 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC09_RS24485 ENOG4108IMY Transcriptional regulator FOC09_RS24490 ENOG4105HDK L-asparaginase FOC09_RS24495 ENOG4108IJ0 Aspartate ammonia-lyase FOC09_RS24510 ENOG4105E2A Dehydrogenase FOC09_RS24570 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC09_RS24600 ENOG4105DWD nucleoside recognition domain protein FOC09_RS24615 ENOG4105FDT acyl-CoA dehydrogenase FOC09_RS24625 ENOG4108ZHR arsR family transcriptional regulator FOC09_RS24630 ENOG4108ZRV stage ii sporulation protein p FOC09_RS24635 ENOG4106N3A copper homeostasis protein cutc FOC09_RS24645 ENOG4107258 Transcriptional regulator FOC09_RS24650 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC09_RS24685 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC09_RS24730 ENOG4105F1N DNA alkylation repair FOC09_RS24740 ENOG4108IQI permease FOC09_RS24745 ENOG4105KNA -acetyltransferase FOC09_RS24750 ENOG410635A Membrane FOC09_RS24830 ENOG4108XET gCN5-related N-acetyltransferase FOC09_RS24860 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC09_RS24870 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC09_RS24905 ENOG4105FS7 Transcriptional regulator FOC09_RS24910 ENOG4108TVJ Nitroreductase FOC09_RS24920 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC09_RS24960 ENOG4105C8Y Acetylornithine aminotransferase FOC09_RS24970 ENOG4105CKK Glycosyl transferase, family 2 FOC09_RS24995 ENOG4105CKK Glycosyl transferase, family 2 FOC09_RS25020 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC09_RS25045 ENOG41068WN FOC09_RS25055 ENOG4108WCX response regulator FOC09_RS25065 ENOG41090T1 Membrane FOC09_RS25080 ENOG4105VMP Transcriptional regulator FOC09_RS25090 ENOG4105G6Z alkaline phosphatase FOC09_RS25095 ENOG4105ECK Fatty Acid Desaturase FOC09_RS25100 ENOG4105E0Y RtcB Protein FOC09_RS25110 ENOG4107258 Transcriptional regulator FOC09_RS25120 ENOG4105II7 pyrroline-5-carboxylate reductase FOC09_RS25125 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC09_RS25155 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC09_RS25175 ENOG41061GT Aldolase FOC09_RS25190 ENOG4105DKT Transcriptional regulator FOC09_RS25200 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC09_RS25210 ENOG4105D4B ABC, transporter FOC09_RS25235 ENOG4105EMN RNA polymerase sigma factor FOC09_RS25245 ENOG41069ER domain protein FOC09_RS25280 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC09_RS25285 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC09_RS25290 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC09_RS25310 ENOG41082JN Transcriptional regulator FOC09_RS25315 ENOG4105EYF MMPL domain protein FOC09_RS25320 ENOG4105EYF MMPL domain protein FOC09_RS25325 ENOG4105EYF MMPL domain protein FOC09_RS25335 ENOG4105C5H ABC transporter FOC09_RS25340 ENOG4105E0M Sulfatase FOC09_RS25345 ENOG4108ZCF integral membrane protein FOC09_RS25355 ENOG4107VMI polysaccharide deacetylase FOC09_RS25365 ENOG4107VC0 DNA alkylation repair enzyme FOC09_RS25415 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC09_RS25435 ENOG4105E09 nadh pyrophosphatase FOC09_RS25460 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC09_RS25465 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC09_RS25470 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC09_RS25480 ENOG4105C02 permease FOC09_RS25550 ENOG4105CHM Aminotransferase FOC09_RS25585 ENOG41089UC methyltransferase, type 11 FOC09_RS25600 ENOG4107BMA Transglycosylase associated protein FOC09_RS25620 ENOG4106K7D Major facilitator family transporter FOC09_RS25625 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC09_RS25665 ENOG4105EPR degv family FOC09_RS25680 ENOG4105DPN Oligoendopeptidase f FOC09_RS25720 ENOG4105BZU Histidine kinase FOC09_RS25725 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC09_RS25770 ENOG4105DTQ mandelate racemase muconate lactonizing FOC09_RS25785 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC09_RS25790 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC09_RS25805 ENOG4107T5V SNARE associated Golgi FOC09_RS25845 ENOG41080HI glycine oxidase FOC09_RS25850 ENOG4105CTU Proline racemase FOC09_RS25855 ENOG4105CTU Proline racemase FOC09_RS25860 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC09_RS25865 ENOG4105C26 Dehydrogenase FOC09_RS25870 ENOG4105BZG amino acid carrier protein FOC09_RS25890 ENOG4108M1A Chitin-binding protein FOC09_RS25935 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC09_RS25955 ENOG4105EEM helicase FOC09_RS26005 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC09_RS26040 ENOG4108M1A Chitin-binding protein FOC09_RS26045 ENOG41082BV acetyltransferase FOC09_RS26050 ENOG4105E66 phosphoriboisomerase A FOC09_RS26075 ENOG4108IJ7 Glycine betaine FOC09_RS26080 ENOG4107SQ8 Glycine betaine FOC09_RS26110 ENOG4105RHY Pfam:UPF0157 FOC09_RS26115 ENOG4105E1F short-chain dehydrogenase reductase FOC09_RS26125 ENOG4107RUY (E1 component), alpha subunit FOC09_RS26135 ENOG4107QKR Dehydrogenase FOC09_RS26155 ENOG41062ES Transcriptional regulator FOC09_RS26175 ENOG4105E98 transcriptional regulator DeoR family FOC09_RS26190 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC09_RS26220 ENOG4107Z3H Transcriptional regulator, TetR family FOC09_RS26225 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FOC09_RS26230 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC09_RS26235 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FOC09_RS26255 ENOG4105MSI germination protein ypeb FOC09_RS26275 ENOG4108V3A UPF0421 protein FOC09_RS26310 ENOG4105FDR Membrane FOC09_RS26320 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC09_RS26345 ENOG4108IUM Glycogen debranching enzyme FOC09_RS26360 ENOG4105DY8 decarboxylase FOC09_RS26380 ENOG4105PAD Hydrolase FOC09_RS26405 ENOG4107VFR oxidoreductase FOC09_RS26445 ENOG4105PKS Excinuclease abc c subunit domain protein FOC09_RS26480 ENOG4105KWG Pfam:DUF1696 FOC09_RS26510 ENOG4108XI2 Domain of unknown function (DUF1963) FOC09_RS26545 ENOG4108Z4K mutator MutT protein FOC09_RS26550 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC09_RS26555 ENOG4105E09 nadh pyrophosphatase FOC09_RS26570 ENOG4105FCD Major Facilitator FOC09_RS26600 ENOG4107Y9U Membrane FOC09_RS26620 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC09_RS26635 ENOG4107Y80 Major Facilitator superfamily FOC09_RS26665 ENOG4108V4B ThiJ pfpI FOC09_RS26700 ENOG4105FQP Beta-lactamase FOC09_RS26710 ENOG4105CJN penicillin-binding protein FOC09_RS26715 ENOG4105CB2 alcohol dehydrogenase FOC09_RS26730 ENOG4108HGU Histidine kinase FOC09_RS26745 ENOG4108JJB ABC transporter FOC09_RS26765 ENOG4107RF6 penicillin-binding protein FOC09_RS26770 ENOG4105BZU Histidine kinase FOC09_RS26780 ENOG410667J hydrolase FOC09_RS26880 ENOG4105ETU transcriptional activator (TenA FOC09_RS26985 ENOG4105CPQ Dehydrogenase FOC09_RS27020 ENOG4105CUV Homoserine Kinase FOC09_RS27035 ENOG4107Y80 Major Facilitator superfamily FOC09_RS27045 ENOG4105FQP Beta-lactamase FOC09_RS27060 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC09_RS27060 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)