locus-tag class description FOC12_RS00030 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC12_RS00060 ENOG4105DWD nucleoside recognition domain protein FOC12_RS00075 ENOG4105FDT acyl-CoA dehydrogenase FOC12_RS00085 ENOG4108ZHR arsR family transcriptional regulator FOC12_RS00090 ENOG4108ZRV stage ii sporulation protein p FOC12_RS00095 ENOG4106N3A copper homeostasis protein cutc FOC12_RS00105 ENOG4107258 Transcriptional regulator FOC12_RS00110 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC12_RS00145 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC12_RS00190 ENOG4105F1N DNA alkylation repair FOC12_RS00200 ENOG4108IQI permease FOC12_RS00205 ENOG4105KNA -acetyltransferase FOC12_RS00210 ENOG410635A Membrane FOC12_RS00290 ENOG4108XET gCN5-related N-acetyltransferase FOC12_RS00320 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC12_RS00330 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC12_RS00365 ENOG4105FS7 Transcriptional regulator FOC12_RS00370 ENOG4108TVJ Nitroreductase FOC12_RS00380 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC12_RS00420 ENOG4105C8Y Acetylornithine aminotransferase FOC12_RS00430 ENOG4105CKK Glycosyl transferase, family 2 FOC12_RS00455 ENOG4105CKK Glycosyl transferase, family 2 FOC12_RS00480 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC12_RS00505 ENOG41068WN FOC12_RS00515 ENOG4108WCX response regulator FOC12_RS00525 ENOG41090T1 Membrane FOC12_RS00540 ENOG4105VMP Transcriptional regulator FOC12_RS00550 ENOG4105G6Z alkaline phosphatase FOC12_RS00555 ENOG4105ECK Fatty Acid Desaturase FOC12_RS00560 ENOG4105E0Y RtcB Protein FOC12_RS00570 ENOG4107258 Transcriptional regulator FOC12_RS00580 ENOG4105II7 pyrroline-5-carboxylate reductase FOC12_RS00585 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC12_RS00615 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC12_RS00635 ENOG41061GT Aldolase FOC12_RS00650 ENOG4105DKT Transcriptional regulator FOC12_RS00660 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC12_RS00670 ENOG4105D4B ABC, transporter FOC12_RS00695 ENOG4105EMN RNA polymerase sigma factor FOC12_RS00705 ENOG41069ER domain protein FOC12_RS00740 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC12_RS00745 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC12_RS00750 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC12_RS00770 ENOG41082JN Transcriptional regulator FOC12_RS00775 ENOG4105EYF MMPL domain protein FOC12_RS00780 ENOG4105EYF MMPL domain protein FOC12_RS00785 ENOG4105EYF MMPL domain protein FOC12_RS00795 ENOG4105C5H ABC transporter FOC12_RS00800 ENOG4105E0M Sulfatase FOC12_RS00805 ENOG4108ZCF integral membrane protein FOC12_RS00815 ENOG4107VMI polysaccharide deacetylase FOC12_RS00825 ENOG4107VC0 DNA alkylation repair enzyme FOC12_RS00875 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC12_RS00895 ENOG4105E09 nadh pyrophosphatase FOC12_RS00920 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC12_RS00925 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC12_RS00930 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC12_RS00940 ENOG4105C02 permease FOC12_RS01010 ENOG4105CHM Aminotransferase FOC12_RS01045 ENOG41089UC methyltransferase, type 11 FOC12_RS01060 ENOG4107BMA Transglycosylase associated protein FOC12_RS01080 ENOG4106K7D Major facilitator family transporter FOC12_RS01085 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC12_RS01125 ENOG4105EPR degv family FOC12_RS01140 ENOG4105DPN Oligoendopeptidase f FOC12_RS01180 ENOG4105BZU Histidine kinase FOC12_RS01185 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC12_RS01230 ENOG4105DTQ mandelate racemase muconate lactonizing FOC12_RS01245 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC12_RS01250 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC12_RS01265 ENOG4107T5V SNARE associated Golgi FOC12_RS01305 ENOG41080HI glycine oxidase FOC12_RS01310 ENOG4105CTU Proline racemase FOC12_RS01315 ENOG4105CTU Proline racemase FOC12_RS01320 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC12_RS01325 ENOG4105C26 Dehydrogenase FOC12_RS01330 ENOG4105BZG amino acid carrier protein FOC12_RS01350 ENOG4108M1A Chitin-binding protein FOC12_RS01395 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC12_RS01415 ENOG4105EEM helicase FOC12_RS01465 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC12_RS01500 ENOG4108M1A Chitin-binding protein FOC12_RS01505 ENOG41082BV acetyltransferase FOC12_RS01510 ENOG4105E66 phosphoriboisomerase A FOC12_RS01535 ENOG4108IJ7 Glycine betaine FOC12_RS01540 ENOG4107SQ8 Glycine betaine FOC12_RS01570 ENOG4105RHY Pfam:UPF0157 FOC12_RS01575 ENOG4105E1F short-chain dehydrogenase reductase FOC12_RS01585 ENOG4107RUY (E1 component), alpha subunit FOC12_RS01595 ENOG4107QKR Dehydrogenase FOC12_RS01615 ENOG41062ES Transcriptional regulator FOC12_RS01635 ENOG4105E98 transcriptional regulator DeoR family FOC12_RS01650 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC12_RS01680 ENOG4107Z3H Transcriptional regulator, TetR family FOC12_RS01685 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FOC12_RS01690 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC12_RS01695 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FOC12_RS01715 ENOG4105MSI germination protein ypeb FOC12_RS01735 ENOG4108V3A UPF0421 protein FOC12_RS01770 ENOG4105FDR Membrane FOC12_RS01780 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC12_RS01805 ENOG4108IUM Glycogen debranching enzyme FOC12_RS01820 ENOG4105DY8 decarboxylase FOC12_RS01840 ENOG4105PAD Hydrolase FOC12_RS01865 ENOG4107VFR oxidoreductase FOC12_RS01905 ENOG4105PKS Excinuclease abc c subunit domain protein FOC12_RS01940 ENOG4105KWG Pfam:DUF1696 FOC12_RS01970 ENOG4108XI2 Domain of unknown function (DUF1963) FOC12_RS02005 ENOG4108Z4K mutator MutT protein FOC12_RS02010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC12_RS02015 ENOG4105E09 nadh pyrophosphatase FOC12_RS02030 ENOG4105FCD Major Facilitator FOC12_RS02060 ENOG4107Y9U Membrane FOC12_RS02080 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC12_RS02095 ENOG4107Y80 Major Facilitator superfamily FOC12_RS02125 ENOG4108V4B ThiJ pfpI FOC12_RS02160 ENOG4105FQP Beta-lactamase FOC12_RS02170 ENOG4105CJN penicillin-binding protein FOC12_RS02175 ENOG4105CB2 alcohol dehydrogenase FOC12_RS02190 ENOG4108HGU Histidine kinase FOC12_RS02205 ENOG4108JJB ABC transporter FOC12_RS02225 ENOG4107RF6 penicillin-binding protein FOC12_RS02230 ENOG4105BZU Histidine kinase FOC12_RS02240 ENOG410667J hydrolase FOC12_RS02340 ENOG4105ETU transcriptional activator (TenA FOC12_RS02445 ENOG4105CPQ Dehydrogenase FOC12_RS02480 ENOG4105CUV Homoserine Kinase FOC12_RS02495 ENOG4107Y80 Major Facilitator superfamily FOC12_RS02505 ENOG4105FQP Beta-lactamase FOC12_RS02520 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC12_RS02520 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC12_RS02560 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC12_RS02570 ENOG4105T9C HD domain FOC12_RS02585 ENOG4105DZ1 carboxypeptidase FOC12_RS02600 ENOG4105DBI uridine monophosphokinase FOC12_RS02605 ENOG4105WCN acetyltransferase FOC12_RS02615 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC12_RS02620 ENOG4107QX3 carboxylase FOC12_RS02625 ENOG4105E39 Enoyl-CoA hydratase FOC12_RS02630 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC12_RS02635 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC12_RS02640 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC12_RS02645 ENOG4105C1G acyl-Coa dehydrogenase FOC12_RS02660 ENOG4107Z3H Transcriptional regulator, TetR family FOC12_RS02670 ENOG4105CJ1 ABC, transporter FOC12_RS02685 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC12_RS02690 ENOG4105CEP NADH dehydrogenase FOC12_RS02695 ENOG4106ANW SMI1_KNR4 FOC12_RS02710 ENOG4105BZU Histidine kinase FOC12_RS02720 ENOG4105C5H ABC transporter FOC12_RS02725 ENOG41067SE Tetr family transcriptional regulator FOC12_RS02745 ENOG4108VXD carboxy-peptidase FOC12_RS02760 ENOG4105VZ8 Transcriptional regulator FOC12_RS02790 ENOG4105DH8 myo-inositol catabolism FOC12_RS02795 ENOG4105D2N Aldolase FOC12_RS02820 ENOG4105CK5 oxidoreductase FOC12_RS02825 ENOG4105IE8 Alpha-ketoglutarate permease FOC12_RS02830 ENOG4105ETE Transcriptional regulator (LacI family FOC12_RS02835 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC12_RS02850 ENOG4107RF6 penicillin-binding protein FOC12_RS02875 ENOG4105CIN aminoacyl-histidine dipeptidase FOC12_RS02905 ENOG41090HR transcriptional regulator FOC12_RS02910 ENOG4107RA9 decarboxylase FOC12_RS02915 ENOG4108I0C methyltransferase FOC12_RS02925 ENOG41088CC tellurite resistance protein tehB FOC12_RS02945 ENOG4108RZE Tetr family transcriptional regulator FOC12_RS02960 ENOG4105C1J atp-dependent rna helicase FOC12_RS02975 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC12_RS02995 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC12_RS03005 ENOG4105RD7 BadF BadG BcrA BcrD FOC12_RS03055 ENOG4108KPJ rna polymerase sigma factor FOC12_RS03085 ENOG4108JCI Transcriptional regulator FOC12_RS03105 ENOG4105BZ1 (ABC) transporter FOC12_RS03110 ENOG4105BZ1 (ABC) transporter FOC12_RS03125 ENOG4108RPX mosc domain containing protein FOC12_RS03130 ENOG4105DND Transcriptional regulator FOC12_RS03145 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC12_RS03150 ENOG4107V2S Transcriptional regulator FOC12_RS03185 ENOG410667J hydrolase FOC12_RS03205 ENOG4105VEQ Cold shock protein FOC12_RS03215 ENOG41068WN FOC12_RS03225 ENOG4105C1Q protoporphyrinogen oxidase FOC12_RS03255 ENOG4105WCN acetyltransferase FOC12_RS03280 ENOG4105EYF MMPL domain protein FOC12_RS03290 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC12_RS03305 ENOG41081I9 integral membrane protein FOC12_RS03335 ENOG4108D32 Methyltransferase FOC12_RS03360 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC12_RS03375 ENOG4105C22 threonyL-tRNA synthetase FOC12_RS03380 ENOG4105FE9 pseudouridine synthase FOC12_RS03400 ENOG4105BZG amino acid carrier protein FOC12_RS03420 ENOG4105K70 DNA-binding protein FOC12_RS03435 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC12_RS03440 ENOG4105WQT MbtH domain protein FOC12_RS03445 ENOG4105CEY Amp-dependent synthetase and ligase FOC12_RS03450 ENOG4105WQI isochorismatase FOC12_RS03455 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC12_RS03460 ENOG4105E4F Isochorismate synthase FOC12_RS03465 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC12_RS03470 ENOG4105FCD Major Facilitator FOC12_RS03490 ENOG4105EYH Exonuclease FOC12_RS03495 ENOG4107RFY SbcCD D subunit FOC12_RS03510 ENOG4105E39 Enoyl-CoA hydratase FOC12_RS03515 ENOG4105N14 lysine exporter protein LysE YggA FOC12_RS03525 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC12_RS03530 ENOG4105C1G acyl-Coa dehydrogenase FOC12_RS03535 ENOG4105CR4 methylisocitrate lyase FOC12_RS03540 ENOG4105DXD 2-methylcitrate dehydratase FOC12_RS03550 ENOG4105W8X HesB YadR YfhF-family protein FOC12_RS03555 ENOG4105CZM Major Facilitator FOC12_RS03560 ENOG4105BZ4 penicillin-binding protein FOC12_RS03600 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC12_RS03705 ENOG4108IBT Inherit from COG: transposase FOC12_RS03720 ENOG4105SZ6 Thioredoxin FOC12_RS03730 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC12_RS03735 ENOG4108N23 SpoOM-related protein FOC12_RS03775 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC12_RS03780 ENOG4108JUB Transcriptional regulator FOC12_RS03785 ENOG4108TSC N-acetyltransferase FOC12_RS03790 ENOG4107S4Y M20 DapE family protein YgeY FOC12_RS03805 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC12_RS03830 ENOG4105C37 (CBS) domain FOC12_RS03865 ENOG4105E90 ABC transporter FOC12_RS03870 ENOG4108IJ8 ABC transporter FOC12_RS03895 ENOG4105CMG Carbohydrate kinase FOC12_RS03900 ENOG4105CMG Carbohydrate kinase FOC12_RS03935 ENOG4105WH1 Two component transcriptional regulator luxr family FOC12_RS03940 ENOG4105BZU Histidine kinase FOC12_RS03945 ENOG4105D8X mechanosensitive ion channel FOC12_RS03980 ENOG4105F0I Aminotransferase FOC12_RS03985 ENOG4108MES Periplasmic binding protein FOC12_RS04000 ENOG4105CAQ asparagine synthetase FOC12_RS04005 ENOG4107Y70 Heat shock protein FOC12_RS04010 ENOG4108KF3 Electron transport protein SCO1 SenC FOC12_RS04015 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC12_RS04020 ENOG4108RCR degv family FOC12_RS04030 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC12_RS04040 ENOG4108UT2 hemolysin iii FOC12_RS04045 ENOG4105E9Q Acyl-transferase FOC12_RS04050 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC12_RS04055 ENOG4107RVG penicillin-binding protein FOC12_RS04070 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC12_RS04090 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC12_RS04120 ENOG4105KD7 acetyltransferase FOC12_RS04135 ENOG4105C0A alcohol dehydrogenase FOC12_RS04140 ENOG4105CY2 Citrate transporter FOC12_RS04145 ENOG4107XGZ Hydrolase FOC12_RS04165 ENOG4105C8J )-transporter FOC12_RS04180 ENOG41062D9 Histidine kinase FOC12_RS04185 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_RS04190 ENOG4107QPK )-transporter FOC12_RS04195 ENOG4105BZW Glycerate kinase FOC12_RS04265 ENOG4105EC2 ftsk spoIIIe FOC12_RS04285 ENOG4105C5S asparaginyl-tRNA synthetase FOC12_RS04305 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC12_RS04330 ENOG4105C75 arginyL-tRNA synthetase FOC12_RS04335 ENOG4107YX5 Pfam:DUF548 FOC12_RS04365 ENOG4108UUM single-stranded DNA-binding protein FOC12_RS04380 ENOG4105C5H ABC transporter FOC12_RS04400 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC12_RS04415 ENOG4105MCT stage V sporulation protein S FOC12_RS04450 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC12_RS04455 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC12_RS04460 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC12_RS04465 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC12_RS04470 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC12_RS04475 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC12_RS04500 ENOG4108ZAF Molybdopterin FOC12_RS04505 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC12_RS04510 ENOG4105D06 uba thif-type nad fad binding protein FOC12_RS04515 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC12_RS04520 ENOG4107V6Q Cyclic nucleotide-binding domain FOC12_RS04545 ENOG4105R3A Nitrate reductase FOC12_RS04550 ENOG4108IUE nitrate reductase beta subunit FOC12_RS04570 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC12_RS04585 ENOG4108V06 Glutathione peroxidase FOC12_RS04610 ENOG4105EMN RNA polymerase sigma factor FOC12_RS04615 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC12_RS04625 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC12_RS04650 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC12_RS04675 ENOG4105KBJ sporulation protein ytfj FOC12_RS04725 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC12_RS04750 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC12_RS04755 ENOG4108JYZ YitT family FOC12_RS04760 ENOG41087PP glycosyltransferase MGT family FOC12_RS04775 ENOG4107RBS Methyltransferase FOC12_RS04780 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC12_RS04790 ENOG4108X4Q Hydrolase FOC12_RS04815 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC12_RS04825 ENOG4108VXD carboxy-peptidase FOC12_RS04835 ENOG4108ZRV stage ii sporulation protein p FOC12_RS04855 ENOG4108Z7R Chaperone CsaA FOC12_RS04875 ENOG4105C37 (CBS) domain FOC12_RS04880 ENOG4105SXS Protein of unknown function (DUF456) FOC12_RS04900 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC12_RS04910 ENOG4108S4H thioesterase Superfamily protein FOC12_RS04920 ENOG4108PJD permease FOC12_RS04935 ENOG4107T5V SNARE associated Golgi FOC12_RS04955 ENOG4105CVJ phosphoglycerate mutase FOC12_RS04980 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC12_RS04990 ENOG4105K4T epimerase FOC12_RS04995 ENOG4105DSE periplasmic solute binding protein FOC12_RS05050 ENOG4105CKI cobalamin synthesis protein FOC12_RS05055 ENOG4107QM2 Aldo Keto reductase FOC12_RS05075 ENOG4105DEN Luciferase family FOC12_RS05090 ENOG4108WPJ Ferritin-like domain FOC12_RS05095 ENOG4108K88 Membrane FOC12_RS05110 ENOG4105C8Q Methyl-accepting chemotaxis FOC12_RS05135 ENOG4107XZQ multidrug resistance protein FOC12_RS05140 ENOG4107SET aldo keto reductase FOC12_RS05145 ENOG4105YVS arsR family transcriptional regulator FOC12_RS05155 ENOG4105KRN Transcriptional regulator, abrb family FOC12_RS05205 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC12_RS05215 ENOG4105YWU small acid-soluble spore protein FOC12_RS05220 ENOG4108WBH protein TIM barrel FOC12_RS05235 ENOG4105CEY Amp-dependent synthetase and ligase FOC12_RS05240 ENOG4105DUU IucA IucC family protein FOC12_RS05250 ENOG4105VRR gCN5-related N-acetyltransferase FOC12_RS05255 ENOG4105KT7 mgtC SapB transporter FOC12_RS05265 ENOG4107VMI polysaccharide deacetylase FOC12_RS05270 ENOG4105BZU Histidine kinase FOC12_RS05275 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC12_RS05285 ENOG4108KGH TRANSCRIPTIONal FOC12_RS05310 ENOG4105D6E homoserine dehydrogenase FOC12_RS05330 ENOG4108ZJ4 polysaccharide deacetylase FOC12_RS05335 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC12_RS05355 ENOG4105BZU Histidine kinase FOC12_RS05360 ENOG4105EFI regulatoR FOC12_RS05410 ENOG4108JJ8 (ABC) transporter FOC12_RS05415 ENOG4108JJ9 ABC, transporter FOC12_RS05420 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC12_RS05425 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC12_RS05435 ENOG4105YGB Transcriptional regulator FOC12_RS05445 ENOG4105MDS 4-oxalocrotonate tautomerase FOC12_RS05455 ENOG4105SKE transcriptional Regulator LysR family FOC12_RS05465 ENOG4105C32 Amino acid ABC transporter (Permease) FOC12_RS05470 ENOG4108IV0 ABC, transporter FOC12_RS05475 ENOG4105C0Z ABC transporter FOC12_RS05485 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC12_RS05490 ENOG4108Z7G MaoC domain protein dehydratase FOC12_RS05510 ENOG4105CKI cobalamin synthesis protein FOC12_RS05520 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC12_RS05525 ENOG4106F5Q Membrane FOC12_RS05530 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC12_RS05535 ENOG4108TVJ Nitroreductase FOC12_RS05540 ENOG4107ZXU DSBA oxidoreductase FOC12_RS05545 ENOG4108Z40 Transcriptional regulator FOC12_RS05550 ENOG4105GZI Transcriptional regulator FOC12_RS05555 ENOG4107RT3 EamA-like transporter family FOC12_RS05565 ENOG4105KTB nuclear export factor GLE1 FOC12_RS05570 ENOG4108T5E Copper resistance protein FOC12_RS05615 ENOG4107STQ Multicopper oxidase FOC12_RS05620 ENOG4107RAQ aminopeptidase FOC12_RS05655 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC12_RS05660 ENOG4105D9N nucleoside FOC12_RS05670 ENOG4107RHR regulatoR FOC12_RS05700 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC12_RS05710 ENOG4105C72 UPF0176 protein FOC12_RS05715 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC12_RS05735 ENOG41068WN FOC12_RS05770 ENOG4105F6J Alpha beta hydrolase fold FOC12_RS05790 ENOG4105CYC Transferase FOC12_RS05795 ENOG4105DY9 regulatoR FOC12_RS05805 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC12_RS05810 ENOG4105C6X Major Facilitator FOC12_RS05835 ENOG4105C7B Threonine dehydratase FOC12_RS05845 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC12_RS05850 ENOG4108ZP8 Acetolactate synthase small subunit FOC12_RS05855 ENOG4105C7K acetolactate synthase FOC12_RS05860 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC12_RS05865 ENOG4105CHR reductase FOC12_RS05870 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC12_RS05885 ENOG4106KE4 Dehydrogenase FOC12_RS05900 ENOG4105H67 Protein of unknown function (DUF421) FOC12_RS05905 ENOG4105X5K response regulator receiver protein FOC12_RS05915 ENOG4105C8J )-transporter FOC12_RS05935 ENOG4105C6T cysteine synthase FOC12_RS05940 ENOG4105EU0 Major facilitator Superfamily FOC12_RS05970 ENOG4105CSR polyphosphate kinase 2 FOC12_RS06010 ENOG4105FVX FOC12_RS06070 ENOG4105C6K Malic enzyme FOC12_RS06075 ENOG4108IJ0 Aspartate ammonia-lyase FOC12_RS06085 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC12_RS06105 ENOG4105CJ1 ABC, transporter FOC12_RS06140 ENOG4106BRA Membrane FOC12_RS06170 ENOG4107QIV Cytochrome c biogenesis protein FOC12_RS06190 ENOG4105EC3 peptidase S51, dipeptidase E FOC12_RS06215 ENOG4105C9Q fumarate hydratase class II FOC12_RS06220 ENOG4105DFD Na H antiporter FOC12_RS06235 ENOG4108PJD permease FOC12_RS06240 ENOG4105CKI cobalamin synthesis protein FOC12_RS06245 ENOG4108UZ3 Transporter FOC12_RS06250 ENOG4105DRR Transcriptional regulator, GntR family FOC12_RS06260 ENOG4105PGM cation diffusion facilitator family transporter FOC12_RS06280 ENOG4105CAQ asparagine synthetase FOC12_RS06310 ENOG4105CVJ phosphoglycerate mutase FOC12_RS06350 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC12_RS06355 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC12_RS06360 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC12_RS06365 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC12_RS06370 ENOG4105DUM transcriptional regulator, lysR family FOC12_RS06395 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC12_RS06415 ENOG4108RZE Tetr family transcriptional regulator FOC12_RS06440 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC12_RS06445 ENOG4105KTQ flagellar basal-body rod protein FOC12_RS06455 ENOG4105D7B Flagellar biosynthesis protein flha FOC12_RS06460 ENOG4105D00 flagellar biosynthetic protein flhB FOC12_RS06470 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC12_RS06475 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC12_RS06485 ENOG4105DD5 Flagellar motor switch protein FOC12_RS06500 ENOG4105E4C Lytic transglycosylase catalytic FOC12_RS06505 ENOG4105I03 Flagellin FOC12_RS06540 ENOG4105K64 Glycosyl transferase, family 2 FOC12_RS06565 ENOG4105BZE flagellar hook protein, FlgE FOC12_RS06600 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC12_RS06610 ENOG41075Z6 flagellar hook-basal body complex protein fliE FOC12_RS06615 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC12_RS06620 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC12_RS06645 ENOG4105E1Q flagellar hook-associated protein FOC12_RS06665 ENOG4105BZU Histidine kinase FOC12_RS06680 ENOG4105DD5 Flagellar motor switch protein FOC12_RS06690 ENOG4107YTP response regulator receiver protein FOC12_RS06695 ENOG4105ER2 Ompa motb domain protein FOC12_RS06700 ENOG4107R0U MotA TolQ exbB proton channel FOC12_RS06710 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC12_RS06765 ENOG41080C8 DUF218 domain FOC12_RS06770 ENOG4105H67 Protein of unknown function (DUF421) FOC12_RS06780 ENOG4108Z5V transcriptional regulator, merr family FOC12_RS06790 ENOG4107RWR Sodium hydrogen exchanger FOC12_RS06800 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC12_RS06865 ENOG41081VK Ribonuclease FOC12_RS06885 ENOG4108SZE gCN5-related N-acetyltransferase FOC12_RS06985 ENOG4105KHC sulfurtransferase FOC12_RS06995 ENOG4108W0I acetyltransferase FOC12_RS07005 ENOG410890F Dynamin family FOC12_RS07010 ENOG4105DHF Membrane FOC12_RS07015 ENOG4105C2W permease FOC12_RS07030 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC12_RS07045 ENOG4105CTD carboxy-peptidase FOC12_RS07050 ENOG4105DVT helicase FOC12_RS07060 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC12_RS07115 ENOG4105BZ4 penicillin-binding protein FOC12_RS07125 ENOG4105CSM endonuclease III FOC12_RS07145 ENOG4105YAC FOC12_RS07150 ENOG4105DVT helicase FOC12_RS07185 ENOG4105CPK Glycosyl transferase (Group 1 FOC12_RS07190 ENOG4105FJR Lmbe family FOC12_RS07205 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC12_RS07210 ENOG4108JYZ YitT family FOC12_RS07240 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC12_RS07245 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC12_RS07250 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC12_RS07265 ENOG41068YB TPR repeat-containing protein FOC12_RS07270 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC12_RS07290 ENOG4105EAH synthase FOC12_RS07300 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC12_RS07315 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC12_RS07345 ENOG41065D1 FOC12_RS07350 ENOG4105S2F FOC12_RS07385 ENOG4105HDK L-asparaginase FOC12_RS07390 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC12_RS07415 ENOG4108S6Z Negative regulator of genetic competence FOC12_RS07420 ENOG4107X2D transcriptional regulator, merr family FOC12_RS07435 ENOG4105I7S Abortive infection protein FOC12_RS07440 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC12_RS07445 ENOG4105T7X FOC12_RS07455 ENOG4108SAX Membrane FOC12_RS07470 ENOG4108WBT adenosyltransferase FOC12_RS07475 ENOG4105BZU Histidine kinase FOC12_RS07480 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_RS07485 ENOG4105CRE cytochrome C FOC12_RS07490 ENOG4107TWT Cytochrome c biogenesis protein FOC12_RS07500 ENOG4105FE9 pseudouridine synthase FOC12_RS07510 ENOG4108JIC nucleoside recognition domain protein FOC12_RS07515 ENOG4105DZ1 carboxypeptidase FOC12_RS07520 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC12_RS07555 ENOG4105BZU Histidine kinase FOC12_RS07570 ENOG4105I3N Conserved Protein FOC12_RS07590 ENOG4105BZ4 penicillin-binding protein FOC12_RS07595 ENOG4107GRR phosphate transport regulator FOC12_RS07600 ENOG4105CJ3 phosphate transporter FOC12_RS07620 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC12_RS07645 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC12_RS07665 ENOG4105WH1 Two component transcriptional regulator luxr family FOC12_RS07670 ENOG4105ENE Histidine kinase FOC12_RS07690 ENOG4105DFD Na H antiporter FOC12_RS07710 ENOG4105C8J )-transporter FOC12_RS07715 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC12_RS07720 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC12_RS07725 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC12_RS07735 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC12_RS07740 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC12_RS07760 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC12_RS07770 ENOG4105E0M Sulfatase FOC12_RS07775 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC12_RS07790 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC12_RS07825 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC12_RS07850 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOC12_RS07860 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC12_RS07865 ENOG4108ZP8 Acetolactate synthase small subunit FOC12_RS07870 ENOG4105C7K acetolactate synthase FOC12_RS07875 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC12_RS07900 ENOG4105KBJ sporulation protein ytfj FOC12_RS07905 ENOG41063Y9 FOC12_RS07910 ENOG4105CZN Potassium uptake protein FOC12_RS07940 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC12_RS07945 ENOG4107QMU Mate efflux family protein FOC12_RS07970 ENOG4105NQC Flavodoxin FOC12_RS07990 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC12_RS08000 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC12_RS08005 ENOG4105EA8 2-Nitropropane dioxygenase FOC12_RS08010 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC12_RS08050 ENOG4105CJ1 ABC, transporter FOC12_RS08060 ENOG4105CZV ABC transporter FOC12_RS08065 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC12_RS08070 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC12_RS08090 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC12_RS08125 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC12_RS08130 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC12_RS08140 ENOG4105BZU Histidine kinase FOC12_RS08145 ENOG4106DF1 FOC12_RS08155 ENOG41090MY MarR family Transcriptional regulator FOC12_RS08160 ENOG4105BZU Histidine kinase FOC12_RS08170 ENOG4105PXI polysaccharide deacetylase FOC12_RS08190 ENOG4105E98 transcriptional regulator DeoR family FOC12_RS08205 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FOC12_RS08220 ENOG4105C4Y ABC transporter FOC12_RS08235 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC12_RS08245 ENOG4105CHR reductase FOC12_RS08265 ENOG4108Z7G MaoC domain protein dehydratase FOC12_RS08270 ENOG410681C small acid-soluble spore protein FOC12_RS08275 ENOG4105CZN Potassium uptake protein FOC12_RS08280 ENOG4107TS3 membrane protein, TerC FOC12_RS08285 ENOG4108QTI )-transporter FOC12_RS08295 ENOG4106A3R peptidase FOC12_RS08315 ENOG4105JXH GntR family transcriptional regulator FOC12_RS08320 ENOG4105BZU Histidine kinase FOC12_RS08325 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_RS08340 ENOG4105CQB FAD linked oxidase domain protein FOC12_RS08345 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC12_RS08350 ENOG4105K4I Scp-like extracellular FOC12_RS08360 ENOG4108YBP pseudouridine synthase FOC12_RS08370 ENOG4105EYF MMPL domain protein FOC12_RS08380 ENOG4107RUE extracellular solute-binding protein family 1 FOC12_RS08385 ENOG4105D38 putrescine abc transporter FOC12_RS08390 ENOG4105F38 ABC transporter, permease FOC12_RS08395 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC12_RS08400 ENOG4105C26 Dehydrogenase FOC12_RS08435 ENOG4105VFR signal peptidase FOC12_RS08440 ENOG4105DZ1 carboxypeptidase FOC12_RS08450 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC12_RS08510 ENOG4105VZ8 Transcriptional regulator FOC12_RS08520 ENOG4105C7S Dehydrogenase FOC12_RS08615 ENOG4105DDQ anthranilate synthase FOC12_RS08625 ENOG4105CK7 Sodium proline symporter FOC12_RS08650 ENOG4108WVJ 2'-5' rna ligase FOC12_RS08700 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC12_RS08710 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC12_RS08715 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC12_RS08735 ENOG4107TVC Glycosyl transferase, family 2 FOC12_RS08755 ENOG4105K64 Glycosyl transferase, family 2 FOC12_RS08775 ENOG4105EMS pseudouridine synthase FOC12_RS08780 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC12_RS08795 ENOG4105MIX Adenylate cyclase FOC12_RS08800 ENOG4108Z18 K06886 hemoglobin FOC12_RS08810 ENOG4105DPN Oligoendopeptidase f FOC12_RS08820 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC12_RS08830 ENOG4108ZCF integral membrane protein FOC12_RS08850 ENOG4105UQX Mate efflux family protein FOC12_RS08855 ENOG4108JQ7 (ABC) transporter FOC12_RS08865 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC12_RS08870 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC12_RS08885 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC12_RS08900 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC12_RS08905 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC12_RS08930 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC12_RS08940 ENOG4108KP7 hydrolase FOC12_RS08950 ENOG41073B9 FOC12_RS08955 ENOG4107AYK membrAne FOC12_RS08965 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC12_RS08975 ENOG4105QNR S1 RNA binding domain protein FOC12_RS09000 ENOG4105CH6 catalase FOC12_RS09005 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC12_RS09010 ENOG4105CAQ asparagine synthetase FOC12_RS09035 ENOG4105ERH Fumarylacetoacetate hydrolase FOC12_RS09080 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC12_RS09085 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination FOC12_RS09100 ENOG4105XVF Competence transcription factor FOC12_RS09115 ENOG4105VEQ Cold shock protein FOC12_RS09130 ENOG4107QP3 malate synthase g FOC12_RS09135 ENOG4105ZU5 s-layer protein FOC12_RS09155 ENOG4105C8Q Methyl-accepting chemotaxis FOC12_RS09160 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC12_RS09185 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC12_RS09200 ENOG41086D8 Transcriptional regulator FOC12_RS09205 ENOG4108AEY RNA polymerase sigma factor FOC12_RS09215 ENOG4107TVP HD domain protein FOC12_RS09250 ENOG4105CNA YD repeat protein FOC12_RS09280 ENOG4105CEY Amp-dependent synthetase and ligase FOC12_RS09290 ENOG4105DF9 Lipoate-protein, ligase FOC12_RS09295 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC12_RS09300 ENOG4106AXD FOC12_RS09330 ENOG4105ECB domain protein FOC12_RS09345 ENOG4105NA0 Transcriptional regulator FOC12_RS09370 ENOG4105C1Q protoporphyrinogen oxidase FOC12_RS09380 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOC12_RS09385 ENOG4105BZ4 penicillin-binding protein FOC12_RS09390 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC12_RS09395 ENOG4105CKV Membrane FOC12_RS09400 ENOG410905X membrane-flanked domain protein FOC12_RS09445 ENOG410905X membrane-flanked domain protein FOC12_RS09475 ENOG4105K59 histidine triad (HIT) protein FOC12_RS09500 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC12_RS09505 ENOG4105EEM helicase FOC12_RS09515 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC12_RS09520 ENOG4105C57 major facilitator superfamily FOC12_RS09545 ENOG4105EMN RNA polymerase sigma factor FOC12_RS09555 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC12_RS09570 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC12_RS09590 ENOG4108MUZ hydrolase FOC12_RS09610 ENOG4105EQ0 Major Facilitator superfamily FOC12_RS09615 ENOG4108IND Tetr family transcriptional regulator FOC12_RS09630 ENOG4105D7V transposase FOC12_RS09640 ENOG4107VRP DNA repair exonuclease FOC12_RS09670 ENOG4105K8R UPF0145 protein FOC12_RS09690 ENOG4105BZU Histidine kinase FOC12_RS09695 ENOG4105BZU Histidine kinase FOC12_RS09700 ENOG4108MJI response regulator FOC12_RS09710 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC12_RS09720 ENOG4105WN5 stage II sporulation protein FOC12_RS09785 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC12_RS09815 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC12_RS09820 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC12_RS09825 ENOG4105CMT Dihydroxyacetone kinase FOC12_RS09835 ENOG4105CMT Dihydroxyacetone kinase FOC12_RS09855 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC12_RS09875 ENOG4108IG5 Transcriptional regulator FOC12_RS09880 ENOG4107P5I polyketide synthase FOC12_RS09925 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC12_RS09955 ENOG4105CDU Replicative dna helicase FOC12_RS10005 ENOG4108MRH transcriptional regulatory protein FOC12_RS10015 ENOG4105CSH Transporter FOC12_RS10045 ENOG4105PKS Excinuclease abc c subunit domain protein FOC12_RS10050 ENOG4108JQ7 (ABC) transporter FOC12_RS10060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC12_RS10100 ENOG4105CTU Proline racemase FOC12_RS10120 ENOG4105DER m42 family FOC12_RS10140 ENOG4105CGU Enoyl-CoA hydratase FOC12_RS10155 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC12_RS10160 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC12_RS10170 ENOG4106AKK s-layer domain-containing protein FOC12_RS10210 ENOG4105CHH sulfate transporter FOC12_RS10225 ENOG4105D4P Coproporphyrinogen iii oxidase FOC12_RS10255 ENOG4107FQX Alpha-acetolactate decarboxylase FOC12_RS10290 ENOG410839P FOC12_RS10305 ENOG4105CDA abc transporter atp-binding protein FOC12_RS10310 ENOG4105DRP amino acid AbC transporter FOC12_RS10325 ENOG4105BZ1 (ABC) transporter FOC12_RS10330 ENOG4105C26 Dehydrogenase FOC12_RS10340 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC12_RS10345 ENOG4105D5Q Arginine ornithine antiporter FOC12_RS10355 ENOG4105CH6 catalase FOC12_RS10360 ENOG4107RKG DJ-1/PfpI family FOC12_RS10370 ENOG4105E5W Transporter FOC12_RS10375 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC12_RS10380 ENOG4105NF4 modulator of drug activity FOC12_RS10405 ENOG4105KPY Small multidrug resistance protein FOC12_RS10410 ENOG4105KPY Small multidrug resistance protein FOC12_RS10420 ENOG4108YXU transcriptional regulator AsnC family FOC12_RS10425 ENOG4108PCN EamA-like transporter family FOC12_RS10460 ENOG4106KNT transcriptional regulator FOC12_RS10470 ENOG4107RWR Sodium hydrogen exchanger FOC12_RS10475 ENOG4105CUB amino acid FOC12_RS10505 ENOG4107T5V SNARE associated Golgi FOC12_RS10540 ENOG4105WEF catalase FOC12_RS10570 ENOG4105C19 ABC transporter FOC12_RS10575 ENOG4107RBB ABC transporter, permease FOC12_RS10580 ENOG41069ER domain protein FOC12_RS10600 ENOG4105VZJ PTS System FOC12_RS10605 ENOG4105VCP PTS System FOC12_RS10610 ENOG4105EMD TRANSCRIPTIONal FOC12_RS10635 ENOG4108KGH TRANSCRIPTIONal FOC12_RS10645 ENOG41087NI Sulfite exporter TauE/SafE FOC12_RS10650 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC12_RS10660 ENOG41085GJ domain protein FOC12_RS10665 ENOG4105VFE sira family FOC12_RS10670 ENOG4107TPS domain protein FOC12_RS10675 ENOG4105VFE sira family FOC12_RS10680 ENOG4105XTG Pfam:DUF156 FOC12_RS10685 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC12_RS10710 ENOG4105ED1 spovr family FOC12_RS10715 ENOG4107Y03 Nitroreductase FOC12_RS10770 ENOG4105C5Y PTS System FOC12_RS10800 ENOG4105C7N Xanthine uracil vitamin C permease FOC12_RS10815 ENOG4108INS Transcriptional regulator FOC12_RS10865 ENOG4105DWF phosphomethylpyrimidine kinase FOC12_RS10870 ENOG4105D06 uba thif-type nad fad binding protein FOC12_RS10885 ENOG41080HI glycine oxidase FOC12_RS10890 ENOG4108VEU Thiamine monophosphate synthase FOC12_RS10900 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC12_RS10910 ENOG4105ETU transcriptional activator (TenA FOC12_RS10930 ENOG41080XQ Signal transduction protein with cbs domains FOC12_RS11055 ENOG4105E2Z phosphate ABC transporter (Permease FOC12_RS11060 ENOG4105C8U phosphate abc transporter FOC12_RS11065 ENOG4105CVA phosphate FOC12_RS11070 ENOG4105CE1 Ferrous iron transport protein b FOC12_RS11075 ENOG4105CE1 Ferrous iron transport protein b FOC12_RS11080 ENOG4105CE1 Ferrous iron transport protein b FOC12_RS11085 ENOG4108NHD germination protein FOC12_RS11100 ENOG4105E1V na solute symporter FOC12_RS11105 ENOG4106CAD Protein of unknown function (DUF3311) FOC12_RS11120 ENOG4108IQI permease FOC12_RS11125 ENOG4105E2S oxidase) subunit II FOC12_RS11130 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC12_RS11170 ENOG4105C7N Xanthine uracil vitamin C permease FOC12_RS11175 ENOG4105C85 amino acid FOC12_RS11195 ENOG4105DUX Transporter FOC12_RS11205 ENOG4107D63 FOC12_RS11210 ENOG4105VZ8 Transcriptional regulator FOC12_RS11215 ENOG41069ER domain protein FOC12_RS11220 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC12_RS11225 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC12_RS11285 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC12_RS11290 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC12_RS11295 ENOG4105CNN ABC, transporter FOC12_RS11310 ENOG4108RVA ribokinase FOC12_RS11315 ENOG4105ETE Transcriptional regulator (LacI family FOC12_RS11325 ENOG41067TZ transcriptional regulator, MarR family FOC12_RS11330 ENOG4105CXY transporter FOC12_RS11340 ENOG4108JQ7 (ABC) transporter FOC12_RS11345 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC12_RS11355 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC12_RS11365 ENOG41068KF Universal stress protein FOC12_RS11370 ENOG4105CHH sulfate transporter FOC12_RS11385 ENOG4105BZU Histidine kinase FOC12_RS11390 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC12_RS11395 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC12_RS11420 ENOG4108IQI permease FOC12_RS11425 ENOG4105DRP amino acid AbC transporter FOC12_RS11430 ENOG4105EAD ABC transporter FOC12_RS11435 ENOG4105CT1 (ABC) transporter FOC12_RS11440 ENOG4105CDA abc transporter atp-binding protein FOC12_RS11445 ENOG4105BZG amino acid carrier protein FOC12_RS11450 ENOG4105CRN Aminoglycoside phosphotransferase FOC12_RS11460 ENOG4105E1K spore germination protein FOC12_RS11475 ENOG4105CG3 alpha amylase, catalytic region FOC12_RS11480 ENOG4105C5Y PTS System FOC12_RS11485 ENOG4107414 GntR family transcriptional regulator FOC12_RS11490 ENOG4105D5Q Arginine ornithine antiporter FOC12_RS11495 ENOG4105BZU Histidine kinase FOC12_RS11510 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC12_RS11515 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC12_RS11520 ENOG4107T89 von Willebrand factor, type A FOC12_RS11530 ENOG4105EXW epimerase dehydratase FOC12_RS11540 ENOG4105DMQ Methyltransferase FOC12_RS11545 ENOG4105E0A ABC, transporter FOC12_RS11550 ENOG4108IHU transport system permease protein FOC12_RS11555 ENOG4105DQ5 transport system permease protein FOC12_RS11560 ENOG4108MES Periplasmic binding protein FOC12_RS11565 ENOG4105DUX Transporter FOC12_RS11580 ENOG4105DAA L-lactate FOC12_RS11585 ENOG4108IJ0 Aspartate ammonia-lyase FOC12_RS11590 ENOG4105C37 (CBS) domain FOC12_RS11595 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC12_RS11600 ENOG4105D9N nucleoside FOC12_RS11605 ENOG4108KGH TRANSCRIPTIONal FOC12_RS11610 ENOG41073R8 VanW family FOC12_RS11645 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC12_RS11650 ENOG4105C59 p-type ATPase FOC12_RS11660 ENOG4105CUB amino acid FOC12_RS11680 ENOG4108JB9 formate dehydrogenase FOC12_RS11685 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC12_RS11690 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC12_RS11695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_RS11700 ENOG4105BZU Histidine kinase FOC12_RS11710 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC12_RS11715 ENOG4108UZ3 Transporter FOC12_RS11725 ENOG4105C6K Malic enzyme FOC12_RS11735 ENOG4108MRH transcriptional regulatory protein FOC12_RS11760 ENOG4105US7 Histidine kinase FOC12_RS11765 ENOG4108STX response regulator FOC12_RS11770 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC12_RS11775 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC12_RS11780 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC12_RS11785 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC12_RS11790 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC12_RS11795 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC12_RS11815 ENOG4105D4T Citrate transporter FOC12_RS11825 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC12_RS11835 ENOG4105DZ6 Band 7 protein FOC12_RS11850 ENOG4105C94 Transporter FOC12_RS11870 ENOG4105CYN Serine protein kinase FOC12_RS11875 ENOG4105BZU Histidine kinase FOC12_RS11880 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC12_RS11890 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC12_RS11900 ENOG4107ZQN disulfide bond FOC12_RS11905 ENOG4108JQC penicillin-binding protein 1A FOC12_RS12020 ENOG4105G5W regulator Fur family FOC12_RS12025 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC12_RS12045 ENOG4108IUW ABC transporter FOC12_RS12055 ENOG4105CBC glutamate synthase FOC12_RS12060 ENOG4107NBY Membrane FOC12_RS12065 ENOG4105BZ1 (ABC) transporter FOC12_RS12085 ENOG4106BXE FOC12_RS12090 ENOG4105CEN a g-specific adenine glycosylase FOC12_RS12095 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC12_RS12125 ENOG4105ECP epimerase FOC12_RS12130 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC12_RS12150 ENOG4105F1A Pyruvate formate-lyase FOC12_RS12170 ENOG4105C3I Nad-dependent epimerase dehydratase FOC12_RS12175 ENOG4107QQG Dehydrogenase FOC12_RS12185 ENOG4105CKK Glycosyl transferase, family 2 FOC12_RS12200 ENOG4108A04 Beta-lactamase FOC12_RS12210 ENOG4105CSV Glutaminase FOC12_RS12235 ENOG4108IQI permease FOC12_RS12245 ENOG4108JUB Transcriptional regulator FOC12_RS12255 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC12_RS12510 ENOG4108IMY Transcriptional regulator FOC12_RS12515 ENOG4105VTR Integrase FOC12_RS12520 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC12_RS12560 ENOG4105UPD Calcium Proton FOC12_RS12565 ENOG410606W general stress protein FOC12_RS12580 ENOG4107ZTW SNARE associated Golgi FOC12_RS12600 ENOG4108IPJ Membrane FOC12_RS12605 ENOG4105C59 p-type ATPase FOC12_RS12610 ENOG4107U9T Pfam:Ribonuclease_BN FOC12_RS12620 ENOG4105KJF protein tyrosine phosphatase FOC12_RS12640 ENOG4108TTB tellurium resistance protein FOC12_RS12645 ENOG4107TS3 membrane protein, TerC FOC12_RS12650 ENOG4106FN3 tellurium resistance protein FOC12_RS12655 ENOG4106FN3 tellurium resistance protein FOC12_RS12660 ENOG4108N0M stress protein FOC12_RS12675 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) FOC12_RS12690 ENOG4105DEU major facilitator superfamily FOC12_RS12710 ENOG41062JF Transcriptional regulator FOC12_RS12735 ENOG4105C5H ABC transporter FOC12_RS12750 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC12_RS12765 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC12_RS12795 ENOG4105CI1 PTS System FOC12_RS12805 ENOG4105C8Q Methyl-accepting chemotaxis FOC12_RS12810 ENOG4105C8Q Methyl-accepting chemotaxis FOC12_RS12820 ENOG4105EAB amino acid AbC transporter FOC12_RS12825 ENOG4105E5Q amino acid AbC transporter FOC12_RS12840 ENOG4105D2S major facilitator superfamily FOC12_RS12845 ENOG410756H nucleotidyltransferase FOC12_RS12865 ENOG4105BZU Histidine kinase FOC12_RS12890 ENOG4106UIA FOC12_RS12895 ENOG4106UIA FOC12_RS12915 ENOG4108V5C ABC transporter FOC12_RS12920 ENOG4105DQ5 transport system permease protein FOC12_RS12925 ENOG4105EHG Permease protein FOC12_RS12930 ENOG4107W7X Aldolase FOC12_RS12940 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FOC12_RS12945 ENOG4105D3R alkyl hydroperoxide reductase FOC12_RS12965 ENOG4105DFD Na H antiporter FOC12_RS12975 ENOG4105DTQ mandelate racemase muconate lactonizing FOC12_RS12990 ENOG4108W15 Protein of unknown function (DUF1456) FOC12_RS13005 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC12_RS13010 ENOG4105D9N nucleoside FOC12_RS13030 ENOG4105KPY Small multidrug resistance protein FOC12_RS13035 ENOG4105C26 Dehydrogenase FOC12_RS13045 ENOG4108JPW Aminotransferase FOC12_RS13050 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC12_RS13055 ENOG4105CBD Diacylglycerol kinase FOC12_RS13080 ENOG410834F Transcriptional regulator FOC12_RS13100 ENOG4105D01 (LipO)protein FOC12_RS13105 ENOG4108UMI ABC transporter, permease FOC12_RS13110 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC12_RS13115 ENOG4108W2Y isochorismatase FOC12_RS13140 ENOG4105C4R Atp-dependent dna helicase FOC12_RS13165 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC12_RS13175 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC12_RS13200 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC12_RS13210 ENOG4105C83 adenylosuccinate lyase FOC12_RS13215 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC12_RS13220 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC12_RS13240 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC12_RS13260 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC12_RS13300 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC12_RS13335 ENOG4105BZU Histidine kinase FOC12_RS13345 ENOG4105C7N Xanthine uracil vitamin C permease FOC12_RS13365 ENOG4108TYN CAAX amino terminal protease family protein FOC12_RS13380 ENOG4105C5H ABC transporter FOC12_RS13385 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC12_RS13390 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC12_RS13395 ENOG41072GX Peptidase M22 Glycoprotease FOC12_RS13400 ENOG4105K8N protein family UPF0079, ATPase FOC12_RS13500 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC12_RS13510 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC12_RS13515 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC12_RS13525 ENOG4107ZXI Rhomboid family FOC12_RS13540 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC12_RS13550 ENOG4108SC4 )-transporter FOC12_RS13560 ENOG4105ERH Fumarylacetoacetate hydrolase FOC12_RS13565 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC12_RS13585 ENOG4108JQ7 (ABC) transporter FOC12_RS13590 ENOG4105C3U ABC transporter FOC12_RS13595 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC12_RS13605 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC12_RS13620 ENOG4105C5H ABC transporter FOC12_RS13640 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC12_RS13645 ENOG4108RE7 deoxyribonuclease FOC12_RS13655 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC12_RS13675 ENOG4105F6E Acyl-transferase FOC12_RS13695 ENOG4105EGI Transcriptional regulator FOC12_RS13705 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC12_RS13715 ENOG4105E0C molybdate abc transporter FOC12_RS13725 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC12_RS13730 ENOG4105II7 pyrroline-5-carboxylate reductase FOC12_RS13740 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC12_RS13745 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC12_RS13775 ENOG4108JQ7 (ABC) transporter FOC12_RS13780 ENOG4105C3U ABC transporter FOC12_RS13785 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC12_RS13790 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC12_RS13805 ENOG4105C2C drug resistance transporter, Bcr CflA FOC12_RS13820 ENOG4105IQ5 FAD linked oxidase domain protein FOC12_RS13830 ENOG4105EE1 crotonyl-CoA reductase FOC12_RS13835 ENOG4105D01 (LipO)protein FOC12_RS13840 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC12_RS13845 ENOG4108UMI ABC transporter, permease FOC12_RS13880 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC12_RS13885 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC12_RS13905 ENOG4108VQT Alpha beta hydrolase fold protein FOC12_RS13910 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC12_RS13925 ENOG4107U5W ybbr family FOC12_RS13930 ENOG4105C8B TIGR00159 family FOC12_RS14010 ENOG4108NMV polysaccharide deacetylase FOC12_RS14025 ENOG4105D1F ATP-binding protein FOC12_RS14050 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC12_RS14055 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC12_RS14060 ENOG4108JJB ABC transporter FOC12_RS14090 ENOG41067V7 50S ribosomal protein L36 FOC12_RS14100 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC12_RS14110 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC12_RS14135 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOC12_RS14240 ENOG4105XPM ribosomal protein FOC12_RS14245 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC12_RS14255 ENOG4107Y49 methyltransferase FOC12_RS14280 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC12_RS14295 ENOG4105QIV RNA polymerase FOC12_RS14300 ENOG4105M0M Tetracycline resistance protein FOC12_RS14305 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC12_RS14320 ENOG4105D7W serine acetyltransferase FOC12_RS14340 ENOG4105CTP PilT protein domain protein FOC12_RS14350 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC12_RS14365 ENOG4108Z0C Uvrb UvrC protein FOC12_RS14395 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC12_RS14405 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC12_RS14410 ENOG4105KRF dihydroneopterin aldolase FOC12_RS14415 ENOG4105EEI dihydropteroate synthase FOC12_RS14420 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC12_RS14425 ENOG4105DDQ anthranilate synthase FOC12_RS14430 ENOG4105CRQ synthase (Component I) FOC12_RS14435 ENOG4105C6T cysteine synthase FOC12_RS14450 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC12_RS14455 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC12_RS14460 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC12_RS14480 ENOG41060GV RNA binding s1 domain protein FOC12_RS14495 ENOG4105VYY sporulation protein yabp FOC12_RS14500 ENOG41082I2 s4 domain protein FOC12_RS14505 ENOG4108IY2 MazG family FOC12_RS14515 ENOG4108M14 stage v sporulation protein t FOC12_RS14520 ENOG4108JA2 transcriptioN-repair coupling factor FOC12_RS14530 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC12_RS14535 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC12_RS14550 ENOG4105KME endoribonuclease L-psp FOC12_RS14555 ENOG4105DFT pur operon repressor FOC12_RS14570 ENOG4105W42 Veg protein FOC12_RS14575 ENOG4105XFA sporulation peptidase YabG FOC12_RS14585 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC12_RS14590 ENOG4105F8V Hydrolase, tatD family FOC12_RS14600 ENOG4105KRN Transcriptional regulator, abrb family FOC12_RS14605 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC12_RS14615 ENOG41060K3 Methyltransferase FOC12_RS14625 ENOG4105MA4 psp1 domain protein FOC12_RS14630 ENOG4105FA2 dna polymerase iii FOC12_RS14640 ENOG4105CXN decarboxylase FOC12_RS14675 ENOG41067KS pro-sigma K processing FOC12_RS14695 ENOG4105C6E dna polymerase iii FOC12_RS14705 ENOG4108Z6B deaminase FOC12_RS14710 ENOG4105GTG Isochorismatase FOC12_RS14720 ENOG4105ZMH deoxynucleoside kinase FOC12_RS14755 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC12_RS14790 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC12_RS14805 ENOG410848D S4 domain protein YaaA FOC12_RS14810 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC12_RS14830 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC12_RS14840 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC12_RS14860 ENOG4107QJE Chromosome Partitioning Protein FOC12_RS14865 ENOG4105FA0 parb-like partition protein FOC12_RS14870 ENOG4108ZDA Sporulation protein YyaC FOC12_RS14875 ENOG4105D8X mechanosensitive ion channel FOC12_RS14880 ENOG4105VDK protein, conserved in bacteria FOC12_RS14885 ENOG4105C3G gtp-binding protein FOC12_RS14895 ENOG4108UUM single-stranded DNA-binding protein FOC12_RS14905 ENOG4108XMW Membrane FOC12_RS14910 ENOG4105BZR domain protein FOC12_RS14920 ENOG4105CDU Replicative dna helicase FOC12_RS14950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_RS14955 ENOG4105BZU Histidine kinase FOC12_RS14970 ENOG4105Q2H domain protein FOC12_RS14975 ENOG4105C0H protease FOC12_RS14995 ENOG4105DPN Oligoendopeptidase f FOC12_RS15010 ENOG4105C1J atp-dependent rna helicase FOC12_RS15020 ENOG4108UT2 hemolysin iii FOC12_RS15025 ENOG4105CMR udp-glucose 4-epimerase FOC12_RS15035 ENOG4105IW1 AmiS UreI transporter FOC12_RS15045 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC12_RS15060 ENOG4107RGD Major Facilitator superfamily FOC12_RS15065 ENOG4108HRK Histidine kinase FOC12_RS15070 ENOG4105DY9 regulatoR FOC12_RS15085 ENOG4106F5Q Membrane FOC12_RS15090 ENOG4105E0X reductase FOC12_RS15100 ENOG41067SE Tetr family transcriptional regulator FOC12_RS15105 ENOG4105CKK Glycosyl transferase, family 2 FOC12_RS15125 ENOG4105C5H ABC transporter FOC12_RS15130 ENOG4105JEU Glycosyl transferase, family 2 FOC12_RS15140 ENOG4108S4H thioesterase Superfamily protein FOC12_RS15150 ENOG4106YBV Methyl-accepting chemotaxis FOC12_RS15155 ENOG4105EN6 Membrane FOC12_RS15175 ENOG41079KZ Major Facilitator Superfamily FOC12_RS15180 ENOG4105DY9 regulatoR FOC12_RS15185 ENOG4105D22 carbon starvation protein FOC12_RS15190 ENOG4105VCD cytoplasmic protein FOC12_RS15195 ENOG4105BZU Histidine kinase FOC12_RS15200 ENOG4105DWF phosphomethylpyrimidine kinase FOC12_RS15210 ENOG4105WH1 Two component transcriptional regulator luxr family FOC12_RS15220 ENOG4108Y4K DNA-binding transcriptional activator FOC12_RS15245 ENOG4105D6E homoserine dehydrogenase FOC12_RS15260 ENOG41090WU lipolytic protein G-D-S-L family FOC12_RS15265 ENOG4105CJ1 ABC, transporter FOC12_RS15270 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC12_RS15280 ENOG4105VCH membrane FOC12_RS15285 ENOG410667J hydrolase FOC12_RS15315 ENOG4108VKI Cell wall hydrolase FOC12_RS15330 ENOG4108IJ2 phosphate acetyltransferase FOC12_RS15345 ENOG4108VCI transcription factor, rsfa family FOC12_RS15360 ENOG4105EHG Permease protein FOC12_RS15365 ENOG4105E0A ABC, transporter FOC12_RS15370 ENOG4108MES Periplasmic binding protein FOC12_RS15375 ENOG4105DCI Phosphohydrolase FOC12_RS15380 ENOG41069HH 4-oxalocrotonate tautomerase FOC12_RS15385 ENOG4108Z4T Peptidase M50 FOC12_RS15390 ENOG4108XFG YwhD family FOC12_RS15395 ENOG4105BZ4 penicillin-binding protein FOC12_RS15400 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC12_RS15405 ENOG4107SWG transcriptional regulator MERR family FOC12_RS15410 ENOG4105DXB Major Facilitator superfamily FOC12_RS15420 ENOG4105CYW agmatinase FOC12_RS15440 ENOG410684U Domain of unknown function (DUF1934) FOC12_RS15450 ENOG4105EMN RNA polymerase sigma factor FOC12_RS15470 ENOG4105IIU Aminopeptidase FOC12_RS15480 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC12_RS15485 ENOG4108M15 ABC transporter FOC12_RS15490 ENOG4105KCT ABC transporter FOC12_RS15495 ENOG4105BZU Histidine kinase FOC12_RS15525 ENOG4105BZU Histidine kinase FOC12_RS15540 ENOG4105DF6 Fe-S oxidoreductase FOC12_RS15550 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC12_RS15555 ENOG4105C1G acyl-Coa dehydrogenase FOC12_RS15560 ENOG4105C1G acyl-Coa dehydrogenase FOC12_RS15595 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC12_RS15600 ENOG4105CBT Fructose-1,6-bisphosphatase FOC12_RS15605 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC12_RS15620 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC12_RS15625 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC12_RS15630 ENOG4108ZXQ stage ii sporulation protein r FOC12_RS15640 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC12_RS15655 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC12_RS15660 ENOG4108VGI doxx family FOC12_RS15675 ENOG4108YZG isomerase FOC12_RS15705 ENOG41062M3 atp synthase FOC12_RS15710 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC12_RS15760 ENOG4105BZU Histidine kinase FOC12_RS15765 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC12_RS15775 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC12_RS15780 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC12_RS15805 ENOG4105D65 subunit l FOC12_RS15810 ENOG4105C8S subunit m FOC12_RS15815 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC12_RS15820 ENOG4106778 Protein of unknown function (DUF1146) FOC12_RS15840 ENOG4108IUW ABC transporter FOC12_RS15845 ENOG4105DY9 regulatoR FOC12_RS15860 ENOG4105FRN stage II sporulation protein FOC12_RS15875 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC12_RS15930 ENOG4105EY8 ABC transporter FOC12_RS15935 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC12_RS15950 ENOG4105CMR udp-glucose 4-epimerase FOC12_RS15955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_RS15960 ENOG4105BZU Histidine kinase FOC12_RS15975 ENOG4105CXY transporter FOC12_RS15995 ENOG4105C19 ABC transporter FOC12_RS16000 ENOG4107RBB ABC transporter, permease FOC12_RS16010 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC12_RS16040 ENOG4105C0D helicase FOC12_RS16045 ENOG4105KBK Zinc finger, swim domain protein FOC12_RS16070 ENOG41069ER domain protein FOC12_RS16075 ENOG4105C94 Transporter FOC12_RS16105 ENOG4105E0M Sulfatase FOC12_RS16115 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC12_RS16125 ENOG4105DAA L-lactate FOC12_RS16165 ENOG4107RSM transcriptional regulator FOC12_RS16170 ENOG4105ECB domain protein FOC12_RS16175 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOC12_RS16190 ENOG4105VZJ PTS System FOC12_RS16200 ENOG4105VCP PTS System FOC12_RS16205 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC12_RS16210 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC12_RS16220 ENOG4105CK1 PTS System FOC12_RS16225 ENOG4105VCP PTS System FOC12_RS16230 ENOG4105F8D glycoside hydrolase family 4 FOC12_RS16235 ENOG410901P UPF0249 protein FOC12_RS16250 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC12_RS16260 ENOG4105ESV Glycosyl transferase, family 4 FOC12_RS16265 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC12_RS16270 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC12_RS16275 ENOG4108KGH TRANSCRIPTIONal FOC12_RS16280 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC12_RS16290 ENOG4105KVH Transcriptional regulator FOC12_RS16305 ENOG41081UC Inherit from COG: Competence protein FOC12_RS16310 ENOG4105VEQ Cold shock protein FOC12_RS16315 ENOG4105MS2 ribosomal subunit Interface protein FOC12_RS16320 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC12_RS16340 ENOG4105CAK Cell division ATP-binding protein ftsE FOC12_RS16345 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC12_RS16350 ENOG4105CN1 protease FOC12_RS16360 ENOG4105BZ1 (ABC) transporter FOC12_RS16375 ENOG4108WS4 fmn reductase FOC12_RS16385 ENOG4105DUM transcriptional regulator, lysR family FOC12_RS16390 ENOG4105HMI Membrane FOC12_RS16415 ENOG4107TXC Transcriptional regulator FOC12_RS16430 ENOG4105D7V transposase FOC12_RS16435 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC12_RS16440 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC12_RS16450 ENOG41086DT Membrane protein of unknown function FOC12_RS16470 ENOG4108S4C acetyltransferase FOC12_RS16480 ENOG4105C3M thioredoxin reductase FOC12_RS16490 ENOG4108Z4K mutator MutT protein FOC12_RS16500 ENOG4105CHW UPF0052 protein FOC12_RS16510 ENOG4105KRI phosphocarrier protein (HPr FOC12_RS16515 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC12_RS16520 ENOG4105H67 Protein of unknown function (DUF421) FOC12_RS16535 ENOG4105CZ3 stage V sporulation protein ad FOC12_RS16540 ENOG41090VF Stage v sporulation protein ac FOC12_RS16560 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC12_RS16585 ENOG4105CP7 Triose-phosphate isomerase FOC12_RS16590 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC12_RS16600 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC12_RS16625 ENOG4105EFC phage portal protein HK97 family FOC12_RS16720 ENOG41067MG lrgb family FOC12_RS16725 ENOG4105XZU Preprotein translocase, subunit SecG FOC12_RS16735 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC12_RS16765 ENOG4105CM4 permease protein FOC12_RS16770 ENOG4108IPW abc transporter atp-binding protein FOC12_RS16785 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FOC12_RS16790 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC12_RS16805 ENOG4105WMR Protein CrcB homolog FOC12_RS16810 ENOG4105WMR Protein CrcB homolog FOC12_RS16820 ENOG4105C8Q Methyl-accepting chemotaxis FOC12_RS16830 ENOG4105D4A Cell wall formation (By similarity) FOC12_RS16835 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC12_RS16850 ENOG4105KVH Transcriptional regulator FOC12_RS16855 ENOG4105F27 Major Facilitator FOC12_RS16860 ENOG4105CV8 reductase FOC12_RS16875 ENOG4108RYK Nad-dependent epimerase dehydratase FOC12_RS16890 ENOG4105D9N nucleoside FOC12_RS16895 ENOG4105D9N nucleoside FOC12_RS16915 ENOG4108URH decarboxylase FOC12_RS16930 ENOG4108RMU ferritin dps family protein FOC12_RS16940 ENOG4105NCW Trka-c domain protein FOC12_RS16945 ENOG4107S91 Sodium hydrogen exchanger FOC12_RS16965 ENOG4105D4Y metalloprotease FOC12_RS16970 ENOG4105VG1 fes assembly suf system protein FOC12_RS16985 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC12_RS16995 ENOG4105BZU Histidine kinase FOC12_RS17000 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_RS17005 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC12_RS17015 ENOG4107ZTW SNARE associated Golgi FOC12_RS17050 ENOG4107AYK membrAne FOC12_RS17060 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC12_RS17070 ENOG4107R7I amino acid FOC12_RS17075 ENOG4108SUT Major Facilitator Superfamily FOC12_RS17090 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC12_RS17110 ENOG4105DZ1 carboxypeptidase FOC12_RS17125 ENOG4105CHU acetyl-coa acetyltransferase FOC12_RS17130 ENOG4105C1G acyl-Coa dehydrogenase FOC12_RS17135 ENOG4108W8B Beta-lactamase domain protein FOC12_RS17160 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC12_RS17205 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC12_RS17240 ENOG4108UMI ABC transporter, permease FOC12_RS17245 ENOG4105D01 (LipO)protein FOC12_RS17250 ENOG4105D01 (LipO)protein FOC12_RS17255 ENOG4105C3K feS assembly ATPase SufC FOC12_RS17260 ENOG4105JRK feS assembly protein SufD FOC12_RS17265 ENOG4105C9B Cysteine desulfurase FOC12_RS17270 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC12_RS17275 ENOG4105DIW FeS assembly protein SUFB FOC12_RS17290 ENOG4107R8B 5'-nucleotidase FOC12_RS17295 ENOG4105KZD Domain of unknown function (DUF1805) FOC12_RS17305 ENOG4105FAA peptidase M23 FOC12_RS17330 ENOG41090T1 Membrane FOC12_RS17335 ENOG4107TXC Transcriptional regulator FOC12_RS17340 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC12_RS17345 ENOG4105MMD transcriptional regulator FOC12_RS17360 ENOG4105CBT Fructose-1,6-bisphosphatase FOC12_RS17375 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC12_RS17380 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC12_RS17390 ENOG4108W5N phosphatidylglycerophosphatase a FOC12_RS17405 ENOG41083MR nifu domain-containing protein FOC12_RS17450 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC12_RS17455 ENOG4105C4B ABC transporter, permease FOC12_RS17460 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC12_RS17485 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC12_RS17505 ENOG4105EWC Purine nucleoside phosphorylase FOC12_RS17535 ENOG4105CEP NADH dehydrogenase FOC12_RS17550 ENOG41069ER domain protein FOC12_RS17570 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC12_RS17590 ENOG4105KA0 thioesterase Superfamily protein FOC12_RS17595 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FOC12_RS17610 ENOG4107R3E Citrate transporter FOC12_RS17620 ENOG4105Y38 Kinase-associated protein B FOC12_RS17630 ENOG4105C87 Aminotransferase class I and II FOC12_RS17640 ENOG4108MUZ hydrolase FOC12_RS17645 ENOG4105C5I Dehydrogenase FOC12_RS17650 ENOG4108ZB6 transcriptional regulator AsnC family FOC12_RS17655 ENOG4105CHM Aminotransferase FOC12_RS17665 ENOG4105WG9 Conserved Protein FOC12_RS17670 ENOG4107QYV phosphohexose isomerase FOC12_RS17680 ENOG4107PBV potassium channel FOC12_RS17685 ENOG4105KT7 mgtC SapB transporter FOC12_RS17720 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC12_RS17815 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC12_RS17835 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOC12_RS17845 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOC12_RS17865 ENOG4105VEQ Cold shock protein FOC12_RS17875 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC12_RS17880 ENOG4105E4F Isochorismate synthase FOC12_RS17885 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOC12_RS17890 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC12_RS17895 ENOG4108IPT Naphthoate synthase FOC12_RS17905 ENOG4105DTQ mandelate racemase muconate lactonizing FOC12_RS17935 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC12_RS17955 ENOG4105FDP GntR family transcriptional regulator FOC12_RS17960 ENOG4105C6Z Gluconate FOC12_RS18000 ENOG41086D8 Transcriptional regulator FOC12_RS18005 ENOG4105C19 ABC transporter FOC12_RS18020 ENOG4107ZTW SNARE associated Golgi FOC12_RS18055 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC12_RS18060 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC12_RS18085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_RS18090 ENOG4105BZU Histidine kinase FOC12_RS18125 ENOG41087YS Phage shock protein A FOC12_RS18170 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC12_RS18175 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC12_RS18180 ENOG4108V2W Carbonate dehydratase FOC12_RS18235 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC12_RS18245 ENOG4105D2X ABC transporter substrate-binding protein FOC12_RS18265 ENOG4107S9D Alpha beta hydrolase FOC12_RS18270 ENOG4105BZU Histidine kinase FOC12_RS18275 ENOG4105BZU Histidine kinase FOC12_RS18280 ENOG4105EGD dinuclear metal center protein, YbgI family FOC12_RS18330 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC12_RS18340 ENOG4105BZF Glycosyl transferase (Group 1 FOC12_RS18345 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC12_RS18350 ENOG4108Z0R Transferase FOC12_RS18355 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC12_RS18385 ENOG4105DA5 (ABC) transporter FOC12_RS18395 ENOG4105N5T Radical SAM Protein FOC12_RS18415 ENOG4105C19 ABC transporter FOC12_RS18430 ENOG4105NCW Trka-c domain protein FOC12_RS18435 ENOG4107S91 Sodium hydrogen exchanger FOC12_RS18440 ENOG410605W Major Facilitator FOC12_RS18470 ENOG4108B31 Spore germination protein FOC12_RS18480 ENOG4105DWV Homoserine O-trans-acetylase FOC12_RS18490 ENOG41085GJ domain protein FOC12_RS18515 ENOG4105D06 uba thif-type nad fad binding protein FOC12_RS18525 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC12_RS18530 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC12_RS18535 ENOG4108ZAF Molybdopterin FOC12_RS18550 ENOG4105CSC Glucose uptake protein FOC12_RS18555 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC12_RS18560 ENOG4108VJ1 Transcriptional regulator (CarD family FOC12_RS18595 ENOG4105CBX hi0933 family FOC12_RS18610 ENOG4105YW5 deoR family transcriptional regulator FOC12_RS18625 ENOG4108IUM Glycogen debranching enzyme FOC12_RS18630 ENOG4108V15 phosphotransferase enzyme family FOC12_RS18645 ENOG4105C8F Beta-lactamase domain protein FOC12_RS18675 ENOG4108VDD TRNA binding domain protein FOC12_RS18720 ENOG4105C88 aminopeptidase FOC12_RS18740 ENOG4105ETE Transcriptional regulator (LacI family FOC12_RS18770 ENOG4105EP9 oxidoreductase FOC12_RS18775 ENOG4107SNB ankyrin repeat protein YahD FOC12_RS18785 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC12_RS18795 ENOG4105DGU Histone deacetylase FOC12_RS18800 ENOG4105W87 Cbs domain FOC12_RS18805 ENOG4105F1V Acetoin utilization protein FOC12_RS18825 ENOG4105EMN RNA polymerase sigma factor FOC12_RS18835 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC12_RS18855 ENOG4105C28 cystathionine FOC12_RS18875 ENOG4106KR7 LysR family Transcriptional regulator FOC12_RS18900 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC12_RS18910 ENOG4105EFZ amidohydrolase FOC12_RS18925 ENOG4105KBJ sporulation protein ytfj FOC12_RS18930 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC12_RS18940 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC12_RS18960 ENOG4108JYZ YitT family FOC12_RS19000 ENOG4107YZX Universal stress protein FOC12_RS19020 ENOG4105VZ8 Transcriptional regulator FOC12_RS19030 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC12_RS19035 ENOG4105Z7P Acetyltransferase (GNAT) family FOC12_RS19070 ENOG4105DC7 peptidase M24 FOC12_RS19105 ENOG4105SFS phosphoesterase RecJ domain protein FOC12_RS19115 ENOG4105VV2 FOC12_RS19120 ENOG4105C0B DNA polymerase III (alpha subunit) FOC12_RS19125 ENOG4105C6K Malic enzyme FOC12_RS19130 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC12_RS19155 ENOG4105FS0 cytoplasmic membrane protein FOC12_RS19160 ENOG4108REF Sporulation integral membrane protein ytvi FOC12_RS19170 ENOG4105BZN citrate synthase FOC12_RS19175 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC12_RS19190 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC12_RS19195 ENOG4105BZU Histidine kinase FOC12_RS19200 ENOG4105C2M dna polymerase I FOC12_RS19205 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC12_RS19215 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC12_RS19220 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC12_RS19230 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC12_RS19250 ENOG4108TDW sporulation protein YtxC FOC12_RS19255 ENOG4105C22 threonyL-tRNA synthetase FOC12_RS19260 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC12_RS19280 ENOG4105CN9 Peptidase m42 family protein FOC12_RS19285 ENOG4108JGH Tetr family transcriptional regulator FOC12_RS19290 ENOG4105CW7 secretion protein, HlyD family FOC12_RS19295 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC12_RS19330 ENOG4108RWN rrna methyltransferase FOC12_RS19340 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC12_RS19345 ENOG4105C5S asparaginyl-tRNA synthetase FOC12_RS19380 ENOG4105DCG PHP domain protein FOC12_RS19390 ENOG4105FE9 pseudouridine synthase FOC12_RS19400 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC12_RS19410 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC12_RS19425 ENOG4105E0A ABC, transporter FOC12_RS19430 ENOG4105KFN sortase, SrtB family FOC12_RS19445 ENOG4105DR4 Methyltransferase FOC12_RS19455 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC12_RS19495 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC12_RS19500 ENOG4105J76 Periplasmic binding protein FOC12_RS19510 ENOG4105CEY Amp-dependent synthetase and ligase FOC12_RS19515 ENOG4107Z3H Transcriptional regulator, TetR family FOC12_RS19520 ENOG41060WC Enoyl-CoA hydratase FOC12_RS19525 ENOG4105BZJ Electron transfer flavoprotein FOC12_RS19530 ENOG4105C10 Electron transfer flavoprotein FOC12_RS19535 ENOG4105K63 Thioredoxin FOC12_RS19550 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC12_RS19560 ENOG4105E33 succinate dehydrogenase FOC12_RS19570 ENOG4108VXD carboxy-peptidase FOC12_RS19575 ENOG4105E14 MotA TolQ exbB proton channel FOC12_RS19585 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC12_RS19590 ENOG4108IUX (ABC) transporter FOC12_RS19595 ENOG4105RHA ABC transporter, permease FOC12_RS19600 ENOG4108Z40 Transcriptional regulator FOC12_RS19605 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC12_RS19615 ENOG4108JCI Transcriptional regulator FOC12_RS19620 ENOG41067S9 phage shock protein C, PspC FOC12_RS19635 ENOG4105DY9 regulatoR FOC12_RS19645 ENOG4108JQ7 (ABC) transporter FOC12_RS19660 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC12_RS19665 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC12_RS19670 ENOG4105DZC cytosine deaminase FOC12_RS19675 ENOG4105DZC cytosine deaminase FOC12_RS19690 ENOG4105PFC Transcriptional regulator FOC12_RS19705 ENOG4105KBX Transcriptional regulator, TetR family FOC12_RS19715 ENOG4108PCX Major Facilitator FOC12_RS19725 ENOG4108XJQ germination protein FOC12_RS19735 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOC12_RS19740 ENOG4105M59 Phosphodiesterase, mj0936 family FOC12_RS19760 ENOG4108QCI YvbH-like oligomerisation region FOC12_RS19785 ENOG4108IUQ atp-dependent protease FOC12_RS19805 ENOG4105K56 Transcriptional regulator FOC12_RS19830 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC12_RS19840 ENOG41068KH stage VI sporulation protein D FOC12_RS19850 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC12_RS19855 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC12_RS19875 ENOG4105DFF Rod shape-determining protein mreb FOC12_RS19880 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOC12_RS19895 ENOG4107QMS site-determining protein FOC12_RS19910 ENOG4105C03 ribonuclease FOC12_RS19920 ENOG4105X36 (ribosomal) protein FOC12_RS19935 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC12_RS19965 ENOG4105CQC Prephenate dehydratase FOC12_RS19970 ENOG4108RPX mosc domain containing protein FOC12_RS19985 ENOG4108IYU L-aspartate oxidase FOC12_RS19990 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC12_RS20015 ENOG41082BM Transcriptional regulator, arsr family FOC12_RS20020 ENOG4108IPJ Membrane FOC12_RS20025 ENOG4108IPJ Membrane FOC12_RS20035 ENOG4108HUF Transporter FOC12_RS20050 ENOG41061AI Protein of unknown function (DUF2905) FOC12_RS20065 ENOG4105VIE preprotein translocase, subunit YajC FOC12_RS20075 ENOG4108QG2 Membrane FOC12_RS20080 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC12_RS20090 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC12_RS20095 ENOG41076HS cation diffusion facilitator family transporter FOC12_RS20100 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC12_RS20110 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC12_RS20120 ENOG4105CUT histidyl-tRNA synthetase FOC12_RS20130 ENOG4105CUZ uba thif-type nad fad binding protein FOC12_RS20135 ENOG4108VCI transcription factor, rsfa family FOC12_RS20140 ENOG4105D1H recombination factor protein RarA FOC12_RS20150 ENOG4105C3J Cysteine desulfurase FOC12_RS20155 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC12_RS20165 ENOG4105C7H Helicase, RecD TraA family FOC12_RS20170 ENOG41060CR FOC12_RS20185 ENOG4105C02 permease FOC12_RS20195 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC12_RS20215 ENOG4105HHA aminodeoxychorismate lyase FOC12_RS20220 ENOG4108VQJ O-methyltransferase FOC12_RS20225 ENOG4105XYU peptidase (U32 family) FOC12_RS20230 ENOG4105CFP Peptidase U32 FOC12_RS20245 ENOG4107XRG penicillin-binding protein FOC12_RS20275 ENOG4105C28 cystathionine FOC12_RS20280 ENOG4108EKI Dehydrogenase FOC12_RS20290 ENOG4108V5C ABC transporter FOC12_RS20295 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC12_RS20345 ENOG4105MIR Phenylalanine 4-monooxygenase FOC12_RS20385 ENOG4108MUZ hydrolase FOC12_RS20395 ENOG4105G6Z alkaline phosphatase FOC12_RS20410 ENOG4108TVJ Nitroreductase FOC12_RS20430 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC12_RS20445 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC12_RS20450 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC12_RS20460 ENOG410812S Rna-binding protein FOC12_RS20470 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC12_RS20480 ENOG4105DXX methyltransferase FOC12_RS20490 ENOG4105KQC Competence protein FOC12_RS20495 ENOG4108UK2 deaminase FOC12_RS20500 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC12_RS20510 ENOG4105TQK DNA polymerase iii, delta' subunit FOC12_RS20535 ENOG4105KVH Transcriptional regulator FOC12_RS20540 ENOG4105CSA Coproporphyrinogen iii oxidase FOC12_RS20550 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOC12_RS20570 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC12_RS20575 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC12_RS20585 ENOG4105KTH gatB Yqey FOC12_RS20590 ENOG41068P3 sporulation protein YqfC FOC12_RS20600 ENOG4105C9A Phoh family FOC12_RS20605 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC12_RS20615 ENOG4107YR5 Diacylglycerol kinase FOC12_RS20620 ENOG4105KG3 cytidine deaminase FOC12_RS20625 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC12_RS20650 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC12_RS20655 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC12_RS20670 ENOG4105EGD dinuclear metal center protein, YbgI family FOC12_RS20695 ENOG41069ZM Protein of unknown function (DUF2624) FOC12_RS20700 ENOG4108JYZ YitT family FOC12_RS20705 ENOG4105FDK ABC transporter FOC12_RS20715 ENOG4105N80 Ferric uptake regulator, Fur family FOC12_RS20740 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC12_RS20750 ENOG4107RF6 penicillin-binding protein FOC12_RS20755 ENOG4105PWN phosphate abc transporter FOC12_RS20760 ENOG4105C8U phosphate abc transporter FOC12_RS20765 ENOG4105E2Z phosphate ABC transporter (Permease FOC12_RS20770 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC12_RS20775 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC12_RS20790 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC12_RS20800 ENOG4105DKQ ROK family FOC12_RS20810 ENOG4105C5X domain protein FOC12_RS20830 ENOG4105C28 cystathionine FOC12_RS20835 ENOG4105C28 cystathionine FOC12_RS20845 ENOG4105C3R Methionine synthase FOC12_RS20850 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC12_RS20970 ENOG4105C0D helicase FOC12_RS21000 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC12_RS21005 ENOG4105CJ1 ABC, transporter FOC12_RS21040 ENOG41080TC multidrug resistance protein FOC12_RS21060 ENOG4105WZW rhodanese family FOC12_RS21065 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC12_RS21085 ENOG4107YBY Hydrolase FOC12_RS21095 ENOG4105CBJ Metal-dependent enzyme FOC12_RS21110 ENOG4105DC7 peptidase M24 FOC12_RS21135 ENOG4105CD2 stage iii sporulation protein aa FOC12_RS21140 ENOG4105KR5 Stage iii sporulation protein FOC12_RS21145 ENOG4108CQH stage III sporulation protein AC FOC12_RS21150 ENOG4105KQ4 Stage iii sporulation protein ad FOC12_RS21160 ENOG410644B Stage III sporulation protein af FOC12_RS21185 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC12_RS21190 ENOG4108ZSR alkaline shock protein FOC12_RS21215 ENOG4105CTB Polyprenyl synthetase FOC12_RS21225 ENOG4105DX0 Hemolysin A FOC12_RS21235 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC12_RS21240 ENOG4105S1Z Stage IV sporulation protein B FOC12_RS21245 ENOG4107QQR Sporulation FOC12_RS21260 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC12_RS21270 ENOG4108JUB Transcriptional regulator FOC12_RS21280 ENOG4107RDP Dehydrogenase FOC12_RS21300 ENOG4105CPP Dehydrogenase, E1 component FOC12_RS21305 ENOG4105C7S Dehydrogenase FOC12_RS21320 ENOG4105G7B Protein of unknown function (DUF2992) FOC12_RS21330 ENOG4108HW3 (ABC) transporter FOC12_RS21335 ENOG4105E5Q amino acid AbC transporter FOC12_RS21340 ENOG4105CDA abc transporter atp-binding protein FOC12_RS21345 ENOG4108QEG Membrane FOC12_RS21350 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC12_RS21365 ENOG4105D9U N-acetyltransferase FOC12_RS21370 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC12_RS21380 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC12_RS21405 ENOG4105EJQ L-serine dehydratase FOC12_RS21410 ENOG4105II7 pyrroline-5-carboxylate reductase FOC12_RS21420 ENOG4108IXY short-chain dehydrogenase reductase FOC12_RS21435 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC12_RS21475 ENOG4105CGH 5'-nucleotidase FOC12_RS21480 ENOG4105DFD Na H antiporter FOC12_RS21490 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC12_RS21500 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC12_RS21505 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC12_RS21510 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC12_RS21515 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FOC12_RS21535 ENOG4108R6K riboflavin synthase, subunit alpha FOC12_RS21540 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC12_RS21560 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC12_RS21565 ENOG4105ETE Transcriptional regulator (LacI family FOC12_RS21575 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC12_RS21595 ENOG4105RHY Pfam:UPF0157 FOC12_RS21605 ENOG4105CPC Aldo Keto reductase FOC12_RS21625 ENOG4105MZ9 stage II sporulation protein m FOC12_RS21630 ENOG4105I3K Ferric uptake regulator, Fur family FOC12_RS21640 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC12_RS21665 ENOG4105D7N magnesium and cobalt transport protein CorA FOC12_RS21695 ENOG4105DVE abc transporter atp-binding protein FOC12_RS21700 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC12_RS21705 ENOG4105DZ1 carboxypeptidase FOC12_RS21710 ENOG41082AN stage II sporulation protein FOC12_RS21720 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC12_RS21725 ENOG4105C8J )-transporter FOC12_RS21745 ENOG41090VF Stage v sporulation protein ac FOC12_RS21750 ENOG4105CZ3 stage V sporulation protein ad FOC12_RS21760 ENOG4105G6R Stage v sporulation protein ae FOC12_RS21770 ENOG4105J7I hydrolase FOC12_RS21775 ENOG4105PTM secreted protein FOC12_RS21780 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC12_RS21815 ENOG4105CE4 GlcNAc 6-P deacetylase FOC12_RS21825 ENOG4105FDP GntR family transcriptional regulator FOC12_RS21835 ENOG4105CID antiterminator FOC12_RS21850 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC12_RS21870 ENOG4106TD9 Diguanylate cyclase FOC12_RS21890 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOC12_RS21915 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC12_RS21925 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FOC12_RS21935 ENOG4105DTD Dehydrogenase FOC12_RS21940 ENOG4105K7K Transcriptional regulator FOC12_RS21980 ENOG4105CHU acetyl-coa acetyltransferase FOC12_RS22025 ENOG4105CG3 alpha amylase, catalytic region FOC12_RS22035 ENOG4107FKK extracellular solute-binding protein family 1 FOC12_RS22045 ENOG4105EG2 ABC transporter, permease FOC12_RS22050 ENOG4105FKQ transcriptional regulator FOC12_RS22055 ENOG4105CHM Aminotransferase FOC12_RS22065 ENOG4108HGU Histidine kinase FOC12_RS22120 ENOG4105UIN FOC12_RS22130 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC12_RS22145 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC12_RS22150 ENOG4105EPM Diguanylate phosphodiesterase FOC12_RS22165 ENOG4107IN1 Protein of unknown function (DUF1797) FOC12_RS22170 ENOG4108XRC Protein of unknown function (DUF458) FOC12_RS22205 ENOG4107ZYR domain protein FOC12_RS22210 ENOG4105CN5 Metallo-Beta-Lactamase FOC12_RS22225 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC12_RS22240 ENOG4105CPP Dehydrogenase, E1 component FOC12_RS22245 ENOG4105C7S Dehydrogenase FOC12_RS22290 ENOG4105CXN decarboxylase FOC12_RS22310 ENOG4105ECY inositol monophosphatase FOC12_RS22320 ENOG4105CI3 gtp-binding protein typa FOC12_RS22325 ENOG4105QA2 FOC12_RS22345 ENOG4108IAB Phoh family FOC12_RS22360 ENOG4105CNI cell division protein FtsW FOC12_RS22365 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC12_RS22415 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC12_RS22430 ENOG4107TB6 phosphoglycerate mutase FOC12_RS22450 ENOG4106H78 methyltransferase FOC12_RS22460 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC12_RS22465 ENOG4105D78 K07001 NTE family protein FOC12_RS22470 ENOG41063PX domain protein FOC12_RS22480 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC12_RS22500 ENOG4108IMY Transcriptional regulator FOC12_RS22545 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC12_RS22560 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOC12_RS22645 ENOG4105CAR Terminase, large subunit FOC12_RS22655 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC12_RS22735 ENOG4105XSJ toxin secretion phage lysis holin FOC12_RS22785 ENOG4105KNH Nucleic acid-binding protein FOC12_RS22825 ENOG41068DC Essential cell division protein (By similarity) FOC12_RS22830 ENOG4105CJN penicillin-binding protein FOC12_RS22835 ENOG4105CJN penicillin-binding protein FOC12_RS22840 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC12_RS22855 ENOG4105CNI cell division protein FtsW FOC12_RS22860 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC12_RS22865 ENOG4105D4A Cell wall formation (By similarity) FOC12_RS22870 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC12_RS22875 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC12_RS22880 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC12_RS22890 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC12_RS22900 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC12_RS22905 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC12_RS22910 ENOG4105DFA alanine racemase domain protein FOC12_RS22920 ENOG41067XK integral membrane protein FOC12_RS22925 ENOG4105DBK s4 domain protein FOC12_RS22950 ENOG4105C34 Pseudouridine synthase FOC12_RS22975 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOC12_RS23030 ENOG4105DC7 peptidase M24 FOC12_RS23035 ENOG4105F23 Fibronectin-binding protein FOC12_RS23045 ENOG4105DSJ YicC domain protein FOC12_RS23065 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC12_RS23070 ENOG4105C25 Primosomal protein n' FOC12_RS23075 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC12_RS23085 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC12_RS23095 ENOG4108ZF3 Phosphatase FOC12_RS23100 ENOG4105D9P serine threonine protein kinase FOC12_RS23105 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC12_RS23110 ENOG4105DJV ribulose-phosphate 3-epimerase FOC12_RS23115 ENOG4105FJ0 thiamine FOC12_RS23130 ENOG4108ZAA Alkaline-shock protein FOC12_RS23135 ENOG4105DP4 dak2 domain fusion protein ylov FOC12_RS23140 ENOG4105CB5 ATP-dependent DNA helicase recG FOC12_RS23155 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC12_RS23160 ENOG4105CHR reductase FOC12_RS23175 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC12_RS23180 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC12_RS23200 ENOG4105VB6 UPF0109 protein FOC12_RS23225 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC12_RS23240 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC12_RS23250 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC12_RS23260 ENOG4108HE4 integrase family FOC12_RS23300 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC12_RS23305 ENOG4105KNE Phosphatidate cytidylyltransferase FOC12_RS23310 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC12_RS23315 ENOG4105DZP Membrane-associated zinc metalloprotease FOC12_RS23325 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC12_RS23335 ENOG4105CHV Transcription elongation factor NusA FOC12_RS23340 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC12_RS23345 ENOG4105VHM ribosomal protein FOC12_RS23355 ENOG4105W7A Protein of unknown function (DUF503) FOC12_RS23365 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC12_RS23370 ENOG4105DTN riboflavin biosynthesis protein ribF FOC12_RS23390 ENOG4105C1V Peptidase, M16 FOC12_RS23400 ENOG4105E35 Dipicolinate synthase subunit A FOC12_RS23405 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC12_RS23410 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC12_RS23420 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC12_RS23430 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC12_RS23440 ENOG4107QZI cell division protein FtsK FOC12_RS23445 ENOG4105FDP GntR family transcriptional regulator FOC12_RS23450 ENOG4105DIH basic membrane FOC12_RS23455 ENOG4108JQ9 ABC transporter FOC12_RS23480 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC12_RS23485 ENOG4105XZV Protein of unknown function (DUF3243) FOC12_RS23500 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC12_RS23525 ENOG4105D48 metallophosphoesterase FOC12_RS23530 ENOG4105MCT stage V sporulation protein S FOC12_RS23535 ENOG4108IGT Dipeptidase FOC12_RS23540 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC12_RS23545 ENOG4105DQU oxidoreductase, subunit beta FOC12_RS23550 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC12_RS23575 ENOG4105DA5 (ABC) transporter FOC12_RS23600 ENOG4107QHE Choloylglycine hydrolase FOC12_RS23610 ENOG410890F Dynamin family FOC12_RS23615 ENOG4105E0M Sulfatase FOC12_RS23620 ENOG4107R6R udp-galactopyranose mutase FOC12_RS23625 ENOG4105F0V Cell wall hydrolase FOC12_RS23650 ENOG4107YEI lmbE family FOC12_RS23655 ENOG4107TTQ Alpha beta hydrolase fold FOC12_RS23670 ENOG41067MG lrgb family FOC12_RS23690 ENOG4105BZU Histidine kinase FOC12_RS23695 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC12_RS23725 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC12_RS23730 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC12_RS23740 ENOG4105CGK Exodeoxyribonuclease III FOC12_RS23760 ENOG4105E0A ABC, transporter FOC12_RS23765 ENOG4105NIV Esterase FOC12_RS23775 ENOG4105VPX protein, conserved in bacteria FOC12_RS23780 ENOG410681U heavy metal transport detoxification protein FOC12_RS23785 ENOG4105C59 p-type ATPase FOC12_RS23790 ENOG4105K70 DNA-binding protein FOC12_RS23795 ENOG4105TMB Formate nitrite transporter FOC12_RS23810 ENOG4105C85 amino acid FOC12_RS23820 ENOG4108SJC Membrane FOC12_RS23830 ENOG4105E98 transcriptional regulator DeoR family FOC12_RS23835 ENOG4105DE4 1-phosphofructokinase FOC12_RS23840 ENOG4105DM4 PTS System FOC12_RS23845 ENOG41069ER domain protein FOC12_RS23875 ENOG4106F1P AAA ATPase, central domain protein FOC12_RS23885 ENOG4105EN6 Membrane FOC12_RS23895 ENOG4105CXI aluminum resistance protein FOC12_RS23900 ENOG4105KV4 Transcriptional regulator FOC12_RS23905 ENOG4105C5F glutamine synthetase FOC12_RS24005 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FOC12_RS24185 ENOG4105XSJ toxin secretion phage lysis holin FOC12_RS24190 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOC12_RS24220 ENOG4105K7K Transcriptional regulator FOC12_RS24240 ENOG4108SVB resolvase FOC12_RS24260 ENOG4105D5T phosphonate abc transporter FOC12_RS24275 ENOG4105D7V transposase FOC12_RS24295 ENOG4105BZ1 (ABC) transporter FOC12_RS24300 ENOG4105BZ1 (ABC) transporter FOC12_RS24315 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC12_RS24340 ENOG41067MG lrgb family FOC12_RS24345 ENOG4105VAW lrga family FOC12_RS24350 ENOG4107RSM transcriptional regulator FOC12_RS24360 ENOG4107QIV Cytochrome c biogenesis protein FOC12_RS24415 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC12_RS24440 ENOG4108903 Formimidoylglutamase FOC12_RS24445 ENOG4108VJ1 Transcriptional regulator (CarD family FOC12_RS24450 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC12_RS24455 ENOG4105CBC glutamate synthase FOC12_RS24460 ENOG4105CK7 Sodium proline symporter FOC12_RS24465 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC12_RS24470 ENOG4105FBA Phospholipase Carboxylesterase FOC12_RS24475 ENOG4105BZU Histidine kinase FOC12_RS24485 ENOG4107AYK membrAne FOC12_RS24535 ENOG4105CEY Amp-dependent synthetase and ligase FOC12_RS24540 ENOG4107ZYJ bioY protein FOC12_RS24545 ENOG4107F3J Amp-dependent synthetase and ligase FOC12_RS24565 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC12_RS24605 ENOG4108I0Z Aconitate hydratase FOC12_RS24610 ENOG4108JJA ABC, transporter FOC12_RS24620 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC12_RS24625 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC12_RS24655 ENOG4105W8X HesB YadR YfhF-family protein FOC12_RS24660 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC12_RS24665 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC12_RS24675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_RS24680 ENOG4105C0H protease FOC12_RS24685 ENOG4105K4P CoA-binding domain protein FOC12_RS24690 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC12_RS24700 ENOG4105D9R oxidoreductase FOC12_RS24710 ENOG4105CIG ABC transporter FOC12_RS24725 ENOG4105EMN RNA polymerase sigma factor FOC12_RS24735 ENOG4108KGH TRANSCRIPTIONal FOC12_RS24800 ENOG4105E1K spore germination protein FOC12_RS24805 ENOG4108JB9 formate dehydrogenase FOC12_RS24815 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC12_RS24820 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC12_RS24830 ENOG4105TMB Formate nitrite transporter FOC12_RS24835 ENOG4105D06 uba thif-type nad fad binding protein FOC12_RS24840 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC12_RS24845 ENOG4108ZAF Molybdopterin FOC12_RS24855 ENOG4105D1F ATP-binding protein FOC12_RS24870 ENOG410696E Membrane FOC12_RS24875 ENOG4105FR1 rard protein FOC12_RS24885 ENOG4105EWU Squalene--hopene cyclase FOC12_RS24895 ENOG4105CHR reductase FOC12_RS24900 ENOG4105C26 Dehydrogenase FOC12_RS24905 ENOG4105RG0 Membrane FOC12_RS24910 ENOG4108IA2 Sodium pantothenate symporter FOC12_RS24925 ENOG4106IQC argininosuccinate lyase FOC12_RS24935 ENOG410904N short-chain dehydrogenase reductase FOC12_RS24955 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC12_RS24975 ENOG4105VEQ Cold shock protein FOC12_RS24990 ENOG4108R1P FOC12_RS25000 ENOG41073R8 VanW family FOC12_RS25005 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC12_RS25020 ENOG4105KT7 mgtC SapB transporter FOC12_RS25030 ENOG4105E39 Enoyl-CoA hydratase FOC12_RS25035 ENOG4105K64 Glycosyl transferase, family 2 FOC12_RS25045 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC12_RS25065 ENOG4105CQB FAD linked oxidase domain protein FOC12_RS25070 ENOG4105C09 Bile acid FOC12_RS25080 ENOG4105RHY Pfam:UPF0157 FOC12_RS25105 ENOG4105CIS alcohol dehydrogenase FOC12_RS25110 ENOG41082BM Transcriptional regulator, arsr family FOC12_RS25135 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC12_RS25165 ENOG4108A04 Beta-lactamase FOC12_RS25170 ENOG4105DPN Oligoendopeptidase f FOC12_RS25180 ENOG4105E5K Alpha-amylase FOC12_RS25190 ENOG4105C98 muts2 protein FOC12_RS25210 ENOG4107V2S Transcriptional regulator FOC12_RS25220 ENOG4107CUJ Protein of unknown function (DUF2690) FOC12_RS25240 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC12_RS25245 ENOG4105NX3 Membrane FOC12_RS25250 ENOG4105DQ5 transport system permease protein FOC12_RS25255 ENOG4105EHG Permease protein FOC12_RS25260 ENOG4108MES Periplasmic binding protein FOC12_RS25280 ENOG4107R3E Citrate transporter FOC12_RS25290 ENOG4108TN2 lmbE family FOC12_RS25360 ENOG4105H3G oxidoreductase FOC12_RS25370 ENOG4105ED2 Beta-lactamase FOC12_RS25395 ENOG4107YXZ hydrolase, family 25 FOC12_RS25410 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC12_RS25435 ENOG4105KAF membrAne FOC12_RS25505 ENOG4105KVH Transcriptional regulator FOC12_RS25525 ENOG4105CHR reductase FOC12_RS25535 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC12_RS25570 ENOG4105KVH Transcriptional regulator FOC12_RS25575 ENOG4105KVH Transcriptional regulator FOC12_RS25580 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC12_RS25590 ENOG4108TZY GntR Family Transcriptional Regulator FOC12_RS25595 ENOG4105KVH Transcriptional regulator FOC12_RS25625 ENOG4105C44 Serine transporter FOC12_RS25630 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC12_RS25645 ENOG4105F27 Major Facilitator FOC12_RS25650 ENOG4105CV8 reductase FOC12_RS25670 ENOG4105D4Y metalloprotease FOC12_RS25675 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC12_RS25690 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC12_RS25695 ENOG4105CIS alcohol dehydrogenase FOC12_RS25700 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC12_RS25705 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC12_RS25720 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC12_RS25725 ENOG4105C6Z Gluconate FOC12_RS25730 ENOG4105CMG Carbohydrate kinase FOC12_RS25735 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC12_RS25740 ENOG4105XDF Protein of unknown function (DUF1272) FOC12_RS25745 ENOG4105DDN Pentapeptide repeat-containing protein FOC12_RS25760 ENOG4105C37 (CBS) domain FOC12_RS25790 ENOG4105EV4 Multidrug resistance protein mdtH FOC12_RS25800 ENOG4105DMQ Methyltransferase FOC12_RS25820 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC12_RS25825 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC12_RS25830 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC12_RS25840 ENOG4108UW5 maltose o-acetyltransferase FOC12_RS25845 ENOG4106UW1 Major Facilitator superfamily FOC12_RS25850 ENOG4105DKQ ROK family FOC12_RS25855 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC12_RS25915 ENOG4105CJ1 ABC, transporter FOC12_RS25925 ENOG4108PSK reductase FOC12_RS25945 ENOG4108RCM Nitroreductase FOC12_RS25950 ENOG4105KVH Transcriptional regulator FOC12_RS25965 ENOG4105CUT histidyl-tRNA synthetase FOC12_RS25970 ENOG4108Z66 YbaK ebsC protein FOC12_RS25980 ENOG41067QW Transcriptional regulator FOC12_RS25995 ENOG4108K8S endonuclease I FOC12_RS26020 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC12_RS26025 ENOG4108JJB ABC transporter FOC12_RS26055 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC12_RS26065 ENOG4105CRW Short chain fatty acid transporter FOC12_RS26075 ENOG4105KBX Transcriptional regulator, TetR family FOC12_RS26080 ENOG4105KPY Small multidrug resistance protein FOC12_RS26085 ENOG4105RXJ FOC12_RS26095 ENOG41069JR FOC12_RS26100 ENOG4105DA5 (ABC) transporter FOC12_RS26120 ENOG4105CZM Major Facilitator FOC12_RS26125 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC12_RS26135 ENOG4108ISG Major Facilitator FOC12_RS26185 ENOG410874W AraC family transcriptional regulator FOC12_RS26190 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC12_RS26205 ENOG4108AEY RNA polymerase sigma factor FOC12_RS26225 ENOG4108JQ1 Dehydrogenase FOC12_RS26240 ENOG4105DVH amino acid FOC12_RS26250 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC12_RS26265 ENOG4108JPW Aminotransferase FOC12_RS26280 ENOG4105EJQ L-serine dehydratase FOC12_RS26285 ENOG4105C44 Serine transporter FOC12_RS26300 ENOG4108JGH Tetr family transcriptional regulator FOC12_RS26305 ENOG4105EQ0 Major Facilitator superfamily FOC12_RS26325 ENOG4107QJQ Mate efflux family protein FOC12_RS26355 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC12_RS26385 ENOG4105TRI Hydrolase FOC12_RS26415 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC12_RS26425 ENOG4106P55 Transcriptional regulator FOC12_RS26435 ENOG4107QR9 Iron-sulfur cluster binding protein FOC12_RS26440 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FOC12_RS26445 ENOG4105DJB Major Facilitator Superfamily FOC12_RS26450 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC12_RS26465 ENOG4108U05 Transcriptional regulator FOC12_RS26480 ENOG4105BZU Histidine kinase FOC12_RS26495 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC12_RS26500 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC12_RS26515 ENOG4105JQZ Methyltransferase FOC12_RS26520 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC12_RS26530 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC12_RS26535 ENOG4108NNI Beta-lactamase domain-containing protein FOC12_RS26550 ENOG4105VZ8 Transcriptional regulator FOC12_RS26570 ENOG4105K6H D-cysteine desulfhydrase FOC12_RS26595 ENOG41062D9 Histidine kinase FOC12_RS26600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_RS26615 ENOG4105IIP Membrane FOC12_RS26625 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC12_RS26630 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC12_RS26705 ENOG4108YXU transcriptional regulator AsnC family FOC12_RS26710 ENOG4105CHR reductase FOC12_RS26720 ENOG4105F7F Chaperone FOC12_RS26735 ENOG41085FC arsR family transcriptional regulator FOC12_RS26740 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC12_RS26745 ENOG4105D6J arsenicaL-resistance protein FOC12_RS26775 ENOG4105DIK (ABC) transporter FOC12_RS26780 ENOG4105CC5 ABC transporter FOC12_RS26785 ENOG4105DSE periplasmic solute binding protein FOC12_RS26790 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC12_RS26795 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC12_RS26810 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC12_RS26815 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC12_RS26830 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC12_RS26835 ENOG4108606 TspO/MBR family FOC12_RS26870 ENOG41090MY MarR family Transcriptional regulator FOC12_RS26895 ENOG4105CHJ isochorismatase hydrolase FOC12_RS26905 ENOG4105CH6 catalase FOC12_RS26910 ENOG4105CGH 5'-nucleotidase FOC12_RS26945 ENOG4105CSV Glutaminase FOC12_RS26980 ENOG4105C6K Malic enzyme FOC12_RS26990 ENOG4105II7 pyrroline-5-carboxylate reductase FOC12_RS27000 ENOG4105CUB amino acid FOC12_RS27005 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC12_RS27015 ENOG4108IMY Transcriptional regulator FOC12_RS27020 ENOG4105HDK L-asparaginase FOC12_RS27025 ENOG4108IJ0 Aspartate ammonia-lyase FOC12_RS27040 ENOG4105E2A Dehydrogenase